Negative feedback loop architecture as a modular predictor of cancer vulnerability — 128 NFLs from KEGG, 59-fold CGC enrichment (Fisher p=9e-44), Irreversible Authority metric, eigenspace cancer candidates (Spiro, 2026)

Reduce LLM inference compute by 4x with no accuracy loss. Oscillatory adapter for pretrained Transformers.

Temporal architecture of signaling oscillations predicts cancer gene function — rise-phase genes map to oncogenes, recovery-phase to tumor suppressors (OR=27.5, p=3.6e-9 across 14 pathways) (Spiro, 2026)