File Reputation
On this page of the Harden System Security, you're able to query any file on the system to retrieve its reputation information. The source of this data is Microsoft's Intelligent Security Graph when the Smart App Control is enabled or in Evaluation Mode, otherwise it will be the SmartScreen which supplies the reputation data for this feature.
Simply browse for a file or drag and drop it into the page to evaluate its reputation. The drag and drop feature only works when the app is not running with elevated privileges.