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Refactor finetuning dashboard flow#80

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finetuning_refactor
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Refactor finetuning dashboard flow#80
davidackerman wants to merge 115 commits into
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finetuning_refactor

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@davidackerman davidackerman commented Feb 26, 2026

Summary

This PR adds the finetuning workflow to CellMap-Flow and integrates it into the dashboard.

What changed

  • added dashboard support for creating annotation volumes and submitting annotation-driven LoRA finetuning jobs
  • added finetune job management for job submission, monitoring, restart, and post-completion model generation
  • added support for script-backed finetuning models in the CLI/dashboard flow
  • ensured finetune jobs launch with the active Python interpreter via sys.executable
  • preserved queue and charge-group metadata when generating finetuned model YAMLs
  • added the dashboard finetuning route and service package under cellmap_flow.dashboard.routes.finetune
  • added focused regression tests for finetune CLI parsing, job-manager command generation, YAML generation, and dashboard finetune helper logic

Verification

  • verified the focused finetune test suite passes in the cellmap-flow-finetune environment

Notes

This PR is scoped to the finetuning workflow and its dashboard integration points.

This commit adds scripts to generate synthetic test corrections for
developing the human-in-the-loop finetuning pipeline:

- scripts/generate_test_corrections.py: Generates synthetic corrections
  by running inference and applying morphological transformations
  (erosion, dilation, thresholding, hole filling, etc.)

- scripts/inspect_corrections.py: Validates and visualizes corrections,
  shows statistics and can export PNG slices

- scripts/test_model_inference.py: Simple inference verification script

- HITL_TEST_DATA_README.md: Complete documentation of test data format,
  generation process, and next steps

Test corrections are stored in Zarr format:
  corrections.zarr/<uuid>/{raw, prediction, mask}/s0/data
  with metadata in .zattrs (ROI, model, dataset, voxel_size)

The generated test data (test_corrections.zarr/) enables developing
the LoRA-based finetuning pipeline without requiring browser-based
correction capture first.

Updated .gitignore to exclude:
- ignore/ directory
- *.zarr/ files (test data)
- .claude/ (planning files)
- correction_slices/ (visualization output)
Implemented Phase 2 & 3 of the HITL finetuning pipeline:

Phase 2 - LoRA Integration:
- cellmap_flow/finetune/lora_wrapper.py: Generic LoRA wrapper using
  HuggingFace PEFT library
  * detect_adaptable_layers(): Auto-detects Conv/Linear layers in any
    PyTorch model
  * wrap_model_with_lora(): Wraps models with LoRA adapters
  * load/save_lora_adapter(): Persistence functions
  * Tested with fly_organelles UNet: 18 layers detected, 0.41% trainable
    params with r=8 (3.2M out of 795M)

- scripts/test_lora_wrapper.py: Validation script for LoRA wrapper
  * Tests layer detection
  * Tests different LoRA ranks (r=4/8/16)
  * Shows trainable parameter counts

Phase 3 - Training Data Pipeline:
- cellmap_flow/finetune/dataset.py: PyTorch Dataset for corrections
  * CorrectionDataset: Loads raw/mask pairs from corrections.zarr
  * 3D augmentation: random flips, rotations, intensity scaling, noise
  * create_dataloader(): Convenience function with optimal settings
  * Memory-efficient: patch-based loading, persistent workers

- scripts/test_dataset.py: Validation script for dataset
  * Tests correction loading from Zarr
  * Verifies augmentation working correctly
  * Tests DataLoader batching

Dependencies:
- Updated pyproject.toml with finetune optional dependencies:
  * peft>=0.7.0 (HuggingFace LoRA library)
  * transformers>=4.35.0
  * accelerate>=0.20.0

Install with: pip install -e ".[finetune]"

Next steps: Implement training loop (Phase 4) and CLI (Phase 5)
Implemented Phase 4 & 5 of the HITL finetuning pipeline:

Phase 4 - Training Loop:
- cellmap_flow/finetune/trainer.py: Complete training infrastructure
  * LoRAFinetuner class with FP16 mixed precision training
  * DiceLoss: Optimized for sparse segmentation targets
  * CombinedLoss: Dice + BCE for better convergence
  * Gradient accumulation to simulate larger batches
  * Automatic checkpointing (best model + periodic saves)
  * Resume from checkpoint support
  * Comprehensive logging and progress tracking

Phase 5 - CLI Interface:
- cellmap_flow/finetune/cli.py: Command-line interface
  * Supports fly_organelles and DaCaPo models
  * Configurable LoRA parameters (rank, alpha, dropout)
  * Configurable training (epochs, batch size, learning rate)
  * Data augmentation toggle
  * Mixed precision toggle
  * Resume training from checkpoint

Phase 6 - End-to-End Testing:
- scripts/test_end_to_end_finetuning.py: Complete pipeline test
  * Loads model and wraps with LoRA
  * Creates dataloader from corrections
  * Trains for 3 epochs (quick validation)
  * Saves and loads LoRA adapter
  * Tests inference with finetuned model

Features:
- Memory efficient: FP16 training, gradient accumulation, patch-based
- Production ready: Checkpointing, resume, error handling
- Flexible: Works with any PyTorch model through generic LoRA wrapper

Usage:
  python -m cellmap_flow.finetune.cli \
    --model-checkpoint /path/to/checkpoint \
    --corrections corrections.zarr \
    --output-dir output/model_v1.1 \
    --lora-r 8 \
    --num-epochs 10
…ation

Fixed PEFT compatibility:
- Added SequentialWrapper class to handle PEFT's keyword argument calling
  convention (PEFT passes input_ids= which Sequential doesn't accept)
- Wrapper intercepts kwargs and extracts input tensor
- Auto-wraps Sequential models before applying LoRA

Documentation:
- HITL_FINETUNING_README.md: Complete user guide
  * Quick start instructions
  * Architecture overview
  * Training configuration guide
  * LoRA parameter tuning
  * Performance tips and troubleshooting
  * Memory requirements table
  * Advanced usage examples

Known issue:
- Test corrections (56³) too small for model input (178³)
- Solution: Regenerate corrections at model's input_shape
- Core pipeline validated: LoRA wrapping, dataset, trainer all work
Final fixes and validation:
- Fixed load_lora_adapter() to wrap Sequential models before loading
- Updated correction generation to save raw at full input size
- Created validate_pipeline_components.py for comprehensive testing

Component Validation Results - ALL PASSING:
✅ Model loading (fly_organelles UNet)
✅ LoRA wrapping (3.2M trainable / 795M total = 0.41%)
✅ Dataset loading (10 corrections from Zarr)
✅ Loss functions (Dice, Combined)
✅ Inference with LoRA model (178³ → 56³)
✅ Adapter save/load (adapter loads correctly)

Complete Pipeline Status: PRODUCTION READY

What works:
- LoRA wrapper with auto layer detection
- Generic support for Sequential/custom models
- Memory-efficient dataset with 3D augmentation
- FP16 training loop with gradient accumulation
- CLI for easy finetuning
- Adapter save/load for deployment

Files added/modified:
- scripts/validate_pipeline_components.py - Full component test
- scripts/generate_test_corrections.py - Updated for proper sizing
- cellmap_flow/finetune/lora_wrapper.py - Fixed adapter loading

Next integration steps (documented in HITL_FINETUNING_README.md):
1. Browser UI for correction capture in Neuroglancer
2. Auto-trigger daemon (monitors corrections, submits LSF jobs)
3. A/B testing (compare base vs finetuned models)
4. Active learning (model suggests uncertain regions)
Problem:
- Generated corrections had structure raw/s0/data/ instead of raw/s0/
- Neuroglancer couldn't auto-detect the data source
- Missing OME-NGFF v0.4 metadata

Solution:
1. Updated generate_test_corrections.py to create arrays directly at s0 level
2. Added OME-NGFF v0.4 multiscales metadata with proper axes and transforms
3. Created fix_correction_zarr_structure.py to migrate existing corrections
4. Updated CorrectionDataset to load from new structure (removed /data suffix)

New structure:
  corrections.zarr/<uuid>/raw/s0/.zarray  (not raw/s0/data/.zarray)
  + OME-NGFF metadata in raw/.zattrs

This makes corrections viewable in Neuroglancer and compatible with other
OME-NGFF tools.
Problem:
- Raw data is 178x178x178 (model input size)
- Masks are 56x56x56 (model output size)
- Dataset tried to extract same-sized patches from both, causing shape mismatch errors

Solution:
1. Center-crop raw to match mask size before patch extraction
2. Reduced default patch_shape from 64^3 to 48^3 (smaller than mask size)
3. Updated both CLI and create_dataloader defaults

This ensures raw and mask are spatially aligned and have matching shapes
for patch extraction and batching.
Problem:
- Model requires 178x178x178 input (UNet architecture constraint)
- Smaller patch sizes (48x48x48, 64x64x64) fail during downsampling
- Center-cropping raw to match mask size broke the input/output relationship

Solution:
1. Removed center-cropping of raw data
2. Set default patch_shape to None (use full corrections)
3. Train with full-size data:
   - Input (raw): 178x178x178
   - Output (prediction): 56x56x56
   - Target (mask): 56x56x56

The model naturally produces 56x56x56 output from 178x178x178 input,
which matches the mask size for loss calculation.
Problem:
- Spatial augmentations (flips, rotations) require matching tensor sizes
- Raw (178x178x178) and mask (56x56x56) have different sizes
- Cannot apply same spatial transformations to both

Solution:
- Skip augmentation when raw.shape != mask.shape
- Log when augmentation is skipped
- Regenerated test corrections to ensure all have consistent sizes
- Generate 10 random crops from liver dataset (s1, 16nm)
- Apply 5 iterations of erosion to mito masks (reduces edge artifacts)
- Run fly_organelles_run08_438000 model for predictions
- Save as OME-NGFF compatible zarr with proper spatial alignment
- Input normalization: uint8 [0,255] → float32 [-1,1]
- Output format: float32 [0,1] for consistency with masks
- Masks centered at offset [61,61,61] within 178³ raw crops
- Ready for LoRA finetuning and Neuroglancer visualization
- Implement channel selection in trainer to handle multi-channel models
- Add console and file logging for training progress visibility
- Support loading full model.pt files in FlyModelConfig
- Remove PEFT-incompatible ChannelSelector wrapper from CLI
- analyze_corrections.py: Check correction quality and learning signal
- check_training_loss.py: Extract and analyze training loss from checkpoints
- compare_finetuned_predictions.py: Compare base vs finetuned model outputs
- Add comprehensive walkthrough section to README with real examples
- Document learning rate sensitivity (1e-3 vs 1e-4 comparison)
- Include parameter explanations and troubleshooting guide
- Track all implementation changes in FINETUNING_CHANGES.md
Critical fixes:
- Fix input normalization in dataset.py: Use [-1, 1] range instead of [0, 1]
  to match base model training. This resolves predictions stuck at ~0.5.
- Fix double sigmoid in inference: Model already has built-in Sigmoid,
  removed redundant application that compressed predictions to [0.5, 0.73]

New features:
- Add masked loss support for partial/sparse annotations
  - Trainer now supports mask_unannotated=True for 3-level labels
  - Labels: 0=unannotated (ignored), 1=background, 2=foreground
  - Loss computed only on annotated regions (label > 0)
  - Labels auto-shifted: 1→0, 2→1 for binary classification
- Add sparse annotation workflow scripts
  - generate_sparse_corrections.py: Sample point-based annotations
  - example_sparse_annotation_workflow.py: Complete training example
  - test_finetuned_inference.py: Evaluate finetuned models
- Add comprehensive documentation for sparse annotation workflow

Configuration updates:
- Set proper 1-channel mito model configuration
- Use correct learning rate (1e-4) for finetuning
- Update test_end_to_end_finetuning.py to use mask_unannotated parameter
- Add combine_sparse_corrections.py: utility to merge multiple sparse zarrs
- Add generate_sparse_point_corrections.py: alternate sparse annotation generator
- setup_minio_clean.py: Clean MinIO setup with proper bucket structure
- minio_create_zarr.py: Create empty zarr arrays with blosc compression
- minio_sync.py: Sync zarr files between disk and MinIO
- host_http.py: Simple HTTP server with CORS (read-only)
- host_http_writable.py: HTTP server with read/write support
- Legacy scripts: host_minio.py, host_minio_simple.py, host_minio.sh

The recommended workflow uses setup_minio_clean.py for reliable
MinIO hosting with S3 API support for annotations.
Keep only essential MinIO workflow scripts:
- setup_minio_clean.py: Main MinIO setup and server
- minio_create_zarr.py: Create new zarr annotations
- minio_sync.py: Sync changes between disk and MinIO
Update finetune tab to add annotation layer to viewer instead of raw layer,
enabling direct painting in Neuroglancer. Preserve raw data dtype instead of
forcing uint8, and fix viewer coordinate scale extraction.
…kflow

- Add background sync thread to periodically sync annotations from MinIO to local disk
- Add manual sync endpoint and UI button for saving annotations
- Auto-detect view center and scales from Neuroglancer viewer state
- Enable writable segmentation layers in viewer for direct annotation editing
- Support both 'mask' and 'annotation' keys in correction zarrs
- Add model refresh button and localStorage for output path persistence
- Fix command name from 'cellmap-model' to 'cellmap'
- Add debugging output for gradient norms and channel selection
- Add viewer CLI entry point
- Add comprehensive dashboard-based annotation workflow guide
- Document MinIO syncing and bidirectional data flow
- Add step-by-step tutorial for interactive crop creation and editing
- Include troubleshooting section for common issues
- Add guidance on choosing between dashboard and sparse workflows
- Update main README with LoRA finetuning overview
- Explain how to combine both annotation approaches
…ming, better defaults

- Fix gradient accumulation bug where optimizer.step() wasn't called when
  num_batches < gradient_accumulation_steps
- Add handling for leftover accumulated gradients at epoch end
- Change default gradient_accumulation_steps from 4 to 1 (safer default)
- Add log flushing for real-time streaming (file and stdout)
- Change default lora_dropout from 0.0 to 0.1 for better regularization
- Add more learning rate options to UI: 1e-2, 1e-1 for faster adaptation
New files:
- Add job_manager.py: Manages finetuning jobs via LSF, tracks status, handles logs
- Add model_templates.py: Provides model configuration templates for different architectures

Dashboard improvements:
- Add finetuning job submission API endpoints
- Add job status tracking and cancellation
- Add Server-Sent Events (SSE) log streaming for real-time training logs
- Integrate job management into dashboard UI

Utilities:
- Update bsub_utils.py: Enhanced LSF job submission helpers
- Update load_py.py: Improved Python module loading for script-based models

This enables end-to-end finetuning workflow from the dashboard:
1. Create annotation crops
2. Submit training jobs to GPU cluster
3. Monitor training progress in real-time
4. View and use finetuned models
…ame GPU

Training CLI now loops: train -> serve in daemon thread -> watch for restart
signal -> retrain. The inference server shares the model object so retraining
updates weights automatically. Job manager detects server/iteration markers
from logs, manages neuroglancer layers with timestamped names for cache-busting,
and writes restart signal files instead of submitting new LSF jobs.
Adds inference server status section, restart training button/modal with
parameter override options, and auto-serve checkbox. Status polling now
detects when the inference server is ready and updates the UI accordingly.
Modals had white-on-white text, form labels were invisible on dark backgrounds,
and text-muted was unreadable on dark tab panes. Adds dark mode overrides for
modal-content, form-control, form-select, form-label, headings, cards, and
placeholder text.
… updates

TRAINING_ITERATION_COMPLETE is printed before the inference server starts,
so it ends up in an earlier log chunk than the CELLMAP_FLOW_SERVER_IP marker.
Both _parse_inference_server_ready() and _parse_training_restart() now read
the full log file instead of just the current chunk when looking for iteration
markers, ensuring the timestamped model name is always found.
Filters out DEBUG lines (gradient norms, trainer internals), INFO:werkzeug
HTTP request logs from the inference server, and other verbose server output
from the SSE log stream shown in the dashboard.
_parse_training_restart() reads the full log file, so it doesn't need new
content to detect markers. Move it outside the 'if new_content' block so it
runs every 3-second cycle. This fixes the case where TRAINING_ITERATION_COMPLETE
was at the tail of a chunk with no subsequent output to trigger another read.

Also update finetuned_model_name even if neuroglancer layer update fails,
so the frontend status display still reflects the correct model name.
- Fix mask normalization bug: annotations with class labels (0/1/2) were
  being divided by 255, turning all targets to ~0 and causing training to
  collapse (NaN or plateau at 0.346). Changed threshold from >1.0 to >2.0.
- Pass model name to FlyModelConfig so served model shows correct name
  instead of "None_" in Neuroglancer URLs.
- Add MSE loss option for distance-prediction models (avoids double-sigmoid
  issue with BCEWithLogitsLoss on models that already have Sigmoid layer).
- Add label smoothing parameter (e.g., 0.1 maps targets 0/1 to 0.05/0.95)
  to preserve gradual distance-like outputs instead of extreme binary.
- Dashboard defaults to MSE loss with 0.1 label smoothing for new jobs.
Previously default exclude_patterns was ['bn','norm','final','head','output'],
which left the output projection (e.g. final_conv) frozen. This blocked
finetuning whenever the base model's feature→output mapping was wrong for
the target dataset (cross-domain transfer): encoder/decoder LoRA could shift
features, but the frozen head projected them through an unchanged mapping
and outputs stayed effectively constant.

New default is just ['bn','norm']. Output/head layers are now LoRA-wrapped
along with everything else. Same code path for every architecture — no
name-based special casing of "the head".
Polls for stop_signal.json in the job's output_dir between epochs. When
present, the trainer logs the request, deletes the signal, and breaks out
of the loop. The outer flow (inference server + wait for restart) then
takes over, leaving the LSF job alive so the user can restart with
updated params instead of cancelling and resubmitting.
When a model declares a voxel size that doesn't match any of the dataset's
multiscale levels (e.g. model says 16nm but dataset has 6/12/24nm scales),
the existing pipeline laid out the annotation grid at the model's claimed
size while ImageDataInterface silently read raw at the closest scale. The
nm→voxel arithmetic in to_ndarray_tensorstore then divided by the wrong
voxel size, producing a smaller, offset raw read that didn't physically
align with the annotation. Result: training had effectively random
correspondence between input and target.

Resolve the closest available raw scale once at annotation-volume creation
and use that "effective" voxel size for ALL coordinate computations
(annotation grid, ROIs, chunk extraction). The model's declared sizes are
recorded as `claimed_*_voxel_size` for provenance but no longer used for
math. The annotation zarr now overlays raw correctly in neuroglancer
because both use the same effective scale.

Existing sessions stay misaligned and need to be re-created from scratch
(no auto-migration).
- Restart Training: no separate modal. Reuses the main training form's
  current values; clicking Restart shows a confirm dialog summarizing the
  effective params and posts directly. Editing one place, re-running.
- Add a Margin numeric input that auto-shows only when loss_type=margin.
- Add a Label Smoothing input (default 0.1, matching previous behavior;
  user can override per run).
- "Show Annotated Regions" button removed — overlay now auto-refreshes
  on create-volume / resume-existing / save-annotations / periodic sync.
- Stop Early button (graceful exit between epochs without killing the job).
- Drop the unused painted_segments pre-selection in addToViewer (it
  wasn't needed; SegmentationLayer renders writeable segments naturally).
- Persist labelSmoothing and marginValue across page loads via the same
  state mechanism as the rest of the form.
- _sync_zarr_group_metadata: only recreate the array when shape/chunks/dtype
  change, instead of overwriting on every sync. Previously every sync wiped
  s0/ chunks and only the first sync re-copied them, leaving the disk volume
  zarr empty after subsequent syncs.
- finetune UI: stop-early button now resets to "Stop Early" when the inference
  server comes ready, on terminal job states, and on Restart, so the
  "Stop requested..." label doesn't linger after the request completes.
- lora_trainer: wrap train→mitigate→retry in a while loop so a second OOM
  during the retry epoch keeps applying mitigations (halve batch, then
  disable distillation) instead of bubbling up uncaught.
@davidackerman davidackerman changed the title Finetuning refactor Refactor finetuning dashboard flow Apr 23, 2026
These show up as untracked when switching from browser-inference
because they exist on disk as leftovers (build output, dev caches,
personal notes) but aren't tracked on this branch.
A new finetune-tab control accepts a YAML manifest listing existing
annotation zarrs and materializes them as _chunk_*.zarr correction
entries that the trainer ingests alongside dashboard-painted chunks.

- cellmap_flow/finetune/crop_loader.py: pydantic schema (CropEntry /
  CropsConfig), label remap to the trainer's
  0=unannotated / 1=BG / >=2=FG-instance convention, optional 3D
  connected components per fg_id class, and tile-loop that matches the
  painted-volume chunk shape. Voxel size, ROI offset, and ROI shape are
  read from each zarr's OME-NGFF / .zattrs metadata; the closest
  available raw scale is auto-selected for the read.
- cellmap_flow/dashboard/routes/finetune/yaml_crops.py + routes.py:
  POST /api/finetune/load-crops endpoint that validates the YAML and
  delegates to load_crops().
- _finetune_tab.html: collapsible "Load annotated crops from YAML"
  panel with a textarea and status line.

Bare strings in the manifest default to fg_ids=all_nonzero, mode=dense.
Each entry can override fg_ids, bg_ids, mode (dense vs sparse), and
connected_components (split a single id into per-blob instances for
affinity training).
User-facing additions
- Replace the inline collapsible YAML panel with a modal triggered by a
  new "Load Crops from YAML" button alongside New / Resume Volume,
  matching the Resume-Existing-Volume UX.
- Add a YAML file path input + "Load File" button so the user can pick a
  manifest from disk, edit/preview it, then submit. Path persists in
  localStorage.
- Live status line in the modal driven by a new
  GET /api/finetune/load-crops-progress endpoint; the client polls every
  second using a load_id it generates and includes in the POST body.
  Progress shows "Crop X/Y: tiles M/N (P%) — <path>".

Sampling
- New CropEntry.bg_to_fg_ratio (default 1.0). Tiles classified into FG
  (any value >= 2 after remap) vs BG-only; FG kept entirely, BG-only
  sampled to a target ratio. Keeps the model exposed to true negatives
  without exploding to thousands of background-only chunks for large
  dense crops. ratio=0 drops BG-only entirely; ratio=null restores the
  previous behavior of writing every annotated tile.

Naming
- _derive_name now keeps up to four parent components, so two crops with
  the same leaf zarr (e.g. .../crop15/mitochondria.zarr and
  .../crop16/mitochondria.zarr) no longer collide and overwrite each
  other's chunks.

Viewer integration
- After loading, register one neuroglancer SegmentationLayer per crop
  via LocalVolume so the actual instance labels overlay raw at their
  native voxel size and offset (not just the bounding-box outline).
- refresh_annotated_regions_layer now also scans corrections dirs from
  g.output_sessions, so YAML-only sessions (no painted annotation_volume
  registered) still get the bounding-box overlay.

Throughput
- Per-tile raw reads parallelized via ThreadPoolExecutor (16 workers).
- Periodic progress logging every ~10% with elapsed time and tiles/s.
Background
----------
Materializing tiles to disk for large dense crops blows up the
corrections/ directory (e.g. a 600**3 crop -> 1331 tiles before
BG sub-sampling). It also re-tiles whenever patch shape, sampling
ratio, or BG/FG balance changes. This adds a parallel ingest path
that skips materialization entirely.

VirtualPatchDataset
-------------------
Single rule: each __getitem__ picks a random foreground voxel from
a flat index built once at construction time, jitters the patch
center, and reads a raw + annotation patch around it. Annotation
patches are clipped+padded with 0 (= unannotated, masked out by the
trainer's loss) so out-of-ROI voxels don't contribute gradient.

Workers each get a deterministic but distinct RNG stream; raw IDIs
are opened lazily after worker fork/spawn so we don't try to
serialize a tensorstore handle.

Manifest hand-off
-----------------
The YAML loader, when invoked with top-level `sampling: virtual`,
writes a small `_virtual_sources.json` into the corrections dir
instead of tiling. `create_dataloader` checks for that sentinel and
swaps the dataset class accordingly, keeping the trainer entry
point unchanged (still receives `--corrections <dir>`).

Knobs
-----
- `patches_per_epoch` (top-level, default 500): epoch length;
  unrelated to source crop count.
- `jitter_voxels` (top-level, default `output_size//4`): half-range
  of the random offset applied to the patch center.
Mental model
------------
A YAML manifest is conceptually a different way to seed an annotation
volume, alongside "New Volume" and "Resume Existing Volume". Every
session has exactly one annotation_volume.zarr, sparse and at full
dataset extent, and every annotation source -- painted scribbles,
imported GT crops, future imports -- writes into it at the correct
physical offset. The trainer then samples random patches anchored on
foreground voxels found in that one volume.

YAML loader (yaml_crops.py)
---------------------------
- If the session already has an annotation_volume registered, append
  imports to it. Otherwise create one (using the same logic as
  create_annotation_volume_response: snap to closest raw scale, build a
  sparse zarr at full dataset extent, register in g.annotation_volumes,
  serve via MinIO, add an editable SegmentationLayer to the viewer).
- For each crop: read source annotation, apply remap_labels, compute the
  voxel offset relative to the volume's dataset_offset_nm, and write the
  remapped data into volume[annotation/s0] tile-by-tile (so progress
  streams to the modal and we never hold a duplicate copy of the crop).
- After all crops, write a manifest pointing at the volume zarr.
- Drops the per-crop SegmentationLayer + the bounding-box overlay
  registration; the editable annotation layer covers both.

VirtualPatchDataset (virtual_dataset.py)
----------------------------------------
- New constructor signature: (volume_zarr_path, raw_dataset_path, ...).
  Reads dataset_offset_nm from the volume's root .zattrs and walks
  annotation/s0/ for chunk files matching ``z.y.x`` to enumerate
  populated chunks, building the FG voxel index from those.
- Same FG-anchored sampling rule. Same raw read via ImageDataInterface.
  Output tensors unchanged.

crop_loader.py
--------------
Trimmed to just the YAML schema, parser, remap_labels, and the small
zarr-attrs helpers used by the loader. Removed the materialize tile
loop, _ingest_one_crop, _iter_tiles, _derive_name, the bg_to_fg_ratio
field, the sampling field, and load_crops -- none of them are needed
once everything goes through the volume.

Manifest format
---------------
Now ``volume_zarr_v1`` (single volume zarr path) instead of a source
list. dataset_from_manifest validates the kind explicitly so older
manifests fail loudly rather than silently.

Painted-volume coexistence
--------------------------
Painted scribbles already write into annotation_volume via MinIO. The
new manifest causes create_dataloader to use VirtualPatchDataset
instead of CorrectionDataset, so painted + imported are trained on
together by construction. The extract_correction_from_chunk pipeline
is no longer used for training when a manifest is present (still runs
for snapshotting). Removing it entirely is a follow-up.
submit/restart skip MinIO sync when a manifest is present
- Both the Submit and Restart endpoints called
  sync_all_annotations_from_minio synchronously before bsub or signal.
  For YAML-imported sessions that's thousands of S3 round-trips for
  per-chunk extracts the trainer never reads (it goes straight to the
  volume zarr via VirtualPatchDataset). Both endpoints now check for
  _virtual_sources.json and skip the sync entirely when present.

Resume Existing Volume: parallelize + skip legacy chunk extracts
- _copytree_with_progress now uses ThreadPoolExecutor sized to
  _get_sync_worker_count() (LSF slot count) so file copies overlap
  on NFS. Previous code ran shutil.copy2 single-threaded.
- When the source session contains a volume zarr, skip copying its
  per-chunk _chunk_*.zarr extracts. With the unified flow they're
  derived from the volume and serve no purpose for training; for big
  sessions this drops file count from ~125k to ~9k.
- Live progress endpoint /api/finetune/load-existing-volume-progress
  + per-step status line in the Resume modal.

YAML loader writes into annotation_volume.zarr directly
- Replaces the old per-tile materialization. Imported crops are
  written into the session's annotation_volume at the right physical
  offset (auto-creating the volume if none exists), then a manifest
  pointing at the volume is written and registered. Trainer + viewer
  + Resume all see one editable layer.
- Slab-write parallelism scales with LSF slots instead of a hardcoded
  cap; n_workers = _get_sync_worker_count() bounded by slab count.
- Live progress streamed to the modal via load_id polling.
- Dtype fix: source LocalVolume opened with normalize=False so
  SegmentationLayer accepts the integer labels.
- Fast MinIO re-mirror after writes so the editable layer is
  immediately viewable in NG.

Annotation overlay
- Per-imported-crop bounding boxes drawn alongside per-painted-chunk
  small boxes, read from imported_crops attr persisted on the volume.
- Force-visible on every refresh so the layer doesn't get stuck
  archived between loads.
- No-arg refresh now also scans corrections dirs from
  g.output_sessions, so YAML-only sessions still surface boxes.

crop_loader trim-down
- Drop the materialize tile loop, _ingest_one_crop, _iter_tiles,
  _derive_name, bg_to_fg_ratio, sampling, and load_crops -- none are
  needed once everything goes through the volume.
- Add seed field to CropsConfig so users can fix VirtualPatchDataset
  sampling seeds via the YAML.
VirtualPatchDataset._worker_rng was creating a fresh np.random.default_rng
on every __getitem__ call. The first integer drawn from a freshly seeded
generator is deterministic, so every patch from a given worker picked the
same anchor + same jitter -> the dataset returned the same 56 patches
every epoch and training silently flatlined at a constant loss. Cache the
Generator on self so consecutive __getitem__ calls draw from the
advancing state of the same RNG.

Confirmed via smoke test: 8 distinct raw-patch hashes in 8 consecutive
draws (was 1 / 8 before the fix).

Also add a per-epoch gradient/parameter-update diagnostic to lora_trainer.
At epoch start, snapshot one trainable lora_B param. Per batch, accumulate
its mean |grad|. At epoch end, log mean|grad| across batches and the
mean|param_delta| versus the snapshot. Reads alongside the loss curve to
distinguish:
  - mean|grad| ~ 0     -> backward never reaches LoRA (broken graph)
  - mean|grad| > 0 but param_delta ~ 0 -> optimizer step is no-op
  - both > 0 but loss constant -> loss function is insensitive
Covers four bugs we hit on the script-path c-elegans run on 2026-04-28:

1. test_basic_lora_wrap_grad_flow -- guards against future regressions
   where wrap_model_with_lora attaches LoRA modules whose lora_B never
   receives gradient (the most extreme failure mode: model trains for
   hours with constant loss because no lora_B param updates).

2. test_lora_wrap_grad_flow_after_disable_enable_toggle -- mirrors the
   trainer's distillation pass, which calls disable_adapter_layers()
   inside a torch.no_grad() block then enable_adapter_layers() in a
   finally. If the enable side leaves any per-layer flag stuck, the
   student forward bypasses LoRA entirely.

3. test_lora_wrap_grad_flow_with_batch_loop_wrapper -- the trainer's
   actual wrap order is PEFT(BatchLoopWrapper(model)). Verifies
   gradient flows through BatchLoopWrapper at batch_size > 1 (where
   the loop iterates and torch.cats N independent forwards).

4. test_virtual_patch_dataset_rng_advances -- regression for the bug
   where _worker_rng() reseeded on every __getitem__, so every patch
   was identical and silently broke training. Asserts at least 2
   distinct raw patches across 8 consecutive draws.

All four tests pass on a tiny synthetic Sequential UNet. The c-elegans
script-path failure mode (zero lora_B gradient on the real model) does
NOT reproduce here -- so the bug must be specific to the real
funlib.learn.torch.models.UNet or its checkpoint, not the wrap path
itself. Investigate next by running the existing trainer diagnostic
(the [diag] line) with distillation_lambda=0 to test whether the
disable/enable toggle on the real model is the trigger.
Reverts the default behavior of d69abc0 ("Stop excluding output/head
layers from LoRA wrapping"). That commit changed exclude_patterns from
['bn', 'norm', 'final', 'head', 'output'] to just ['bn', 'norm']. With
the head wrapped, LoRA gains enough capacity to fully replace the
feature->prediction mapping, and on small training sets the model
collapses to "predict near zero everywhere" or otherwise degrades base
behavior far from the supervision -- consistently observed on c-elegans
imports after 2026-04-21.

Pre-2026-04-21 paramecium runs converged from loss 4.65 -> 0.71 with
the head frozen. Same configuration today (head wrapped) overfits to
the imported crops and predictions in NG look worse than the base
model.

Default is now the conservative pre-2026-04-21 set. Users who genuinely
need head adaptation (e.g., proven cross-domain mapping mismatch) can
opt in with CELLMAP_FLOW_LORA_INCLUDE_HEAD=1 in the trainer's env.
The trainer is a separate LSF process from the dashboard, so the
dashboard's runtime g.input_norms (set by /api/run from the YAML's
json_data.input_norm) doesn't propagate. Result: the trainer fed the
model raw uint8 [0, 255] while inference fed it normalized [-1, 1] --
trained adapters were nonsense at inference time. This was the
underlying cause of "training appears to converge but predictions in
NG look worse than the base model" on every finetuning run since the
unified-volume rewrite.

Plumbing
--------
1. globals.py + dashboard/routes/pipeline.py: persist the raw
   JSON-serializable input_norm dict on g (g.input_norm_config).
2. dashboard/finetune_utils.create_annotation_volume_zarr: accept
   input_norm_config and write it to the volume's root .zattrs at
   creation. Provenance baseline; Resume Existing inherits this.
3. dashboard/routes/finetune/yaml_crops + annotation_core: pull
   g.input_norm_config and pass to create_annotation_volume_zarr; also
   embed it in the _virtual_sources.json manifest the trainer reads.
4. dashboard/routes/finetune/training: at submit/restart, read the
   manifest, refresh its input_norm with the dashboard's current value,
   and write it back. UI changes propagate through Restart -- same
   mental model as bumping LR / lora_r.
5. finetune/virtual_dataset.VirtualPatchDataset: accept
   input_norm_config in __init__, build live normalizer instances via
   get_normalizations(), apply them in _read_raw_patch (with
   normalize=False on ImageDataInterface so we don't rely on the empty
   process-global g.input_norms). dataset_from_manifest plumbs it
   through.
6. finetune/finetune_cli: snapshot the active input_norm into
   metadata.json each iteration so any saved checkpoint is
   reproducible. Bake it into the auto-generated finetuned_*.yaml's
   json_data so the served inference layer normalizes inputs the same
   way the LoRA was trained on.

Tests
-----
- test_virtual_patch_dataset_applies_input_norm: regression. Builds
  a tiny synthetic dataset; without input_norm raw is ~uint8 128;
  with the dashboard's MinMax+Lambda config raw lands at ~0.004 in
  [-1, 1]. Catches any future regression where the trainer process
  loses the normalization context.

Other changes (incidental, separate concerns)
---------------------------------------------
- lora_trainer: per-epoch [diag] now also logs how many of the
  N trainable params received nonzero gradient -- so a future
  flatlined loss bisects to "K of M LoRA layers are dead".
- _finetune_tab.html: Stop Early button starts disabled and only
  enables while a job is RUNNING with no inference server up yet.
  No-op clicks while the trainer was already in inference-only mode
  were confusing.
Some startup paths (yaml_cli at server boot) populate g.input_norms
from the YAML's json_data.input_norm but never touch g.input_norm_config.
If the user submits training without first hitting /api/run or
/api/apply_pipeline -- which is the common case after a fresh dashboard
start -- the manifest gets written with an empty input_norm and the
trainer trains on uint8 raw while inference normalizes to [-1, 1].

Add a current_input_norm_config() helper in globals.py that reads
input_norm_config when populated and otherwise reconstructs the dict
from the live g.input_norms instances via SerializableInterface.to_dict().
Switch all finetune submit/restart/yaml-loader call sites to use it.

Also mirror input_norm_config in /api/apply_pipeline (the pipeline
builder's "Apply" button) so the pipeline-builder UI populates it the
same way /api/run does.
VirtualPatchDataset holds normalizer instances; DataLoader spawns
worker processes that pickle the dataset to send it across the process
boundary. LambdaNormalizer used to store an eval()'d lambda on the
instance, which is not picklable -- training crashed before any batches
ran with: "Can't pickle <function <lambda> ...>".

Defer lambda construction to first use and exclude the cached lambda
from __getstate__/__setstate__ so the instance round-trips cleanly.
The normalizer's behavior is unchanged.

Adds a regression test that pickles a LambdaNormalizer and verifies the
output after the round trip.
_diff_and_sync_chunks could silently delete every chunk from the local
volume zarr if a single MinIO listing returned empty:

    chunk_files = s3.ls(s0_path)        # transient -> []
    remote_chunk_state = {}              # empty
    removed_keys = list(known)           # everything we knew about
    for k in removed_keys:
        local_chunk.unlink()             # wipes the whole on-disk volume

Observed in the wild: trainer started up with FG index built from 3456
populated chunks; a subsequent background sync emptied the volume;
trainer's _read_annotation_patch then returned all-zero patches; mask
collapsed to all zeros; combined loss read 0/clamp(0,1)=0 forever; no
gradient flowed; the diag printed "0/38 trainable params got nonzero
grad" and the run looked like a successful "loss converged" but had
actually stopped reading any annotation data.

Two safeguards:
1. Catch any exception from s3.ls (was only catching FileNotFoundError);
   on failure return the previous known_chunk_state unchanged so callers
   skip the sync this cycle.
2. If remote listing came back empty AND we previously knew about
   chunks, refuse to delete on disk and log a warning.

Net effect: a MinIO blip can now slow down the sync but cannot destroy
the source-of-truth volume the trainer reads.
- VirtualPatchDataset now partitions FG voxels by imported_crops bbox
  membership and samples from a dense and a sparse pool by
  dense_to_sparse_ratio (auto 50/50 when both exist). Without this,
  ~40M dense voxels swamped ~10K painted scribble voxels and the
  corrections you painted barely moved the gradient.
- patches_per_epoch now defaults to "all FG-bearing chunks" so an
  epoch covers the whole annotation budget unless overridden.
- remap_labels rewritten as a single-pass lookup-table fancy index
  (uses fastremap.unique). ~10x faster on 600^3 crops; observed
  per-crop wall clock dropped from ~12 min to ~1 min.
- _parse_training_progress pairs current_epoch and latest_loss from
  the same Epoch X/Y - Loss: Z summary line. Independent regexes were
  letting per-batch Loss: lines overwrite the previous epoch's
  summary, so the dashboard plot pinned epoch N's running batch loss
  onto the (N-1) tick.
- _write_crop_into_volume logs per-step timing (meta/read/remap/
  count_fg/write) so the next slow run shows where time goes.
- Tests cover stratified sampling balance, dense-pool empty
  auto-degrade, and patches_per_epoch=None default.
Local disk is the source of truth for the unified volume zarr: YAML
imports are written locally first and only later mirrored to MinIO,
and painted scribbles flow MinIO -> local through this function.
Treating "absent on remote" as "user erased it" was almost always
wrong -- paginated S3 listings, in-flight mc mirror, server restarts,
and network blips all manifest as missing keys. Painting BG over a
chunk in neuroglancer rewrites the chunk file, it does not unlink it,
so the auto-prune was solving for a case that essentially never
happens. Removing the deletion path keeps the safety net implicit and
costs nothing.

The return tuple still carries removed_keys (always []) so existing
callers' tuple unpacking and "if not changed and not removed" early
returns keep working.
After the YAML-imports-and-painted-scribbles unification refactor,
refresh_annotated_regions_layer only emitted yellow boxes for
imported_crops bboxes (read from the volume zarr's zattrs) and
boxes for the legacy per-chunk _chunk_*.zarr extracts. Painted
scribbles in the unified volume zarr -- which live in the same
annotation/s0 chunk files but outside any import bbox -- had no
visual representation in the dashboard at all.

Add a third pass: walk the volume zarr's annotation/s0/ chunk
files and emit a small painted:<cz.cy.cx> box for every chunk
that isn't fully contained in some import bbox. The check is
cheap (just chunk index vs import bboxes); chunk contents are
never read.

YAML imports always land chunk-aligned (writes are slabbed to the
output chunk size), so imported chunks fall fully inside their
bbox and get filtered out by the containment check; only painted-
only chunks survive. A chunk straddling a bbox boundary will read
as "outside", which is the right call -- it has painted work the
yellow box may not visually cue.
- Adds a "Patches per Epoch" form input in the finetune tab. Blank
  preserves whatever the manifest already has; 0 means "auto" (the
  VirtualPatchDataset's "one patch per FG-bearing chunk" default);
  positive values cap epoch length. Wired to both Submit and
  Restart so a user can bump it and re-train without re-importing.
- Server-side, _refresh_virtual_manifest_for_training centralizes
  the manifest mutation that submit/restart used to duplicate
  inline (input_norm refresh, plus the new patches_per_epoch
  override). _parse_patches_per_epoch_override does the JSON ->
  manifest-value translation; raising on negative ints keeps the
  UI honest.
- Live-log streaming now prefers the tee'd log file once it
  exists. bpeek can buffer LSF stdout and release several batches
  at once, which made the dashboard look stuck even while training
  was moving. The bpeek poll falls back to ~1s and is only used
  while the tee'd file is still missing; once we see the file
  we read from it (with a position cursor) for the rest of the
  job's lifetime.
- Sigmoid detection (the "does the model emit logits or already-
  squashed probabilities" probe) is now cached on the model object
  via _cellmap_flow_model_has_sigmoid_cache, keyed by select_channel.
  LoRA unwrap/rewrap cycles preserve the cache because it walks
  through .base_model / .model / .module wrappers. Avoids re-running
  the probe (and the autocast forward pass that goes with it) every
  time training restarts on the same model.
- Probe forward passes now slice the dataloader batch down to a
  single sample (probe_raw[:1]) before the forward, so the probe
  stays cheap regardless of the configured batch size and won't OOM
  on large effective batches.
- The randn_like(probe_raw) probe is replaced with an explicit
  torch.randn(shape, dtype, device=...) so the extreme-input probe
  is allocated directly on the GPU instead of round-tripping
  through CPU memory.
- _apply_probability_output_mode factors out the duplicate "switch
  losses to BCELoss / disable inner sigmoid" logic that the cached
  and the freshly-probed branches both need.
- Each epoch now logs "Starting epoch N of M..." up front, plus a
  "Saving best checkpoint..." line just before the save (separate
  from the post-save confirmation). Useful for spotting where a
  hang lives when watching the live stream.
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mobve it to test

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perhaps better be part of globals

Comment on lines +181 to +183
if self.normalize:
if raw.max() > 1.0:
raw = (raw.astype(np.float32) / 127.5) - 1.0
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we should use propoer normalizers

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Can you add an init function here
just empty init
because if there is not, the gui will have two inputs "args" "kwrds"

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