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SimonYip22/README.md

Simon Yip

MBBS and machine learning engineer building end-to-end clinical systems across time-series modelling and clinical NLP

Currently contributing to ML research workflows at RadNomics involving large-scale radiology report generation, data augmentation, and proprietary LLM evaluation

Featured Work

Clinical Entity Extraction-Validation System

Python · PyTorch · Hugging Face Transformers · Scikit-learn · Pandas · FastAPI · Docker · Google Cloud Run · GitHub Actions

  • Hybrid clinical NLP system generating structured entity outputs from adult ICU progress notes
  • Implemented rule-based regex extraction schemas for recall-focused extraction of 3 clinical entity types
  • Fine-tuned a BioClinicalBERT classifier on 1000+ manually annotated entities, and integrated precision-oriented threshold tuning for final entity validation
  • Extracted 780,000+ structured entities from a preprocessed ICU corpus of 160,000+ notes (30,000+ stays)
  • Transformer validation achieved +45.9% in precision and −83.3% in false positives relative to rule-only baseline
  • Deployed inference pipeline as stateless, containerised API on Google Cloud Run with GitHub Actions versioning

Live API · Repository · Zenodo DOI

Clinical entity extraction and validation system architecture

Time-Series ICU Patient Deterioration Predictor

Python · PyTorch · LightGBM · Scikit-learn · Pandas · NumPy · SHAP

  • Dual-architecture ICU early warning system combining a Temporal CNN (TCN) and LightGBM to predict NEWS2-derived deterioration outcomes across 3 clinical risk dimensions
  • Transformed clinical data across 140 ICU stays using CO2 retainer logic, GCS mapping, and oxygen protocols
  • Engineered 171 timestamp-level features (8 vital parameters; 96-hour windows) and 40 aggregated patient-level features from 70,000+ extracted time-series observations
  • TCN achieved +9.3% AUC improvement for acute-event detection; LightGBM achieved −68% Brier score and −48% RMSE for prolonged risk exposure
  • Implemented clinician-interpretable SHAP and saliency mapping for feature contribution insights

Repository · Zenodo DOI

Temporal convolutional network architecture

Professional Experience

Applied Machine Learning Engineer @ RadNomics Ltd

  • Processed 2.3M+ radiology reports and developed a data augmentation pipeline generating 17M+ report pairs across 7 clinically relevant reconstruction tasks
  • Ran large-scale ML research workflows in containerised remote environments on GKE-based cloud infrastructure, with Git-based collaboration
  • Built an LLM benchmarking framework across 6 candidate language models, generating 42,000 reconstructed reports and evaluating using text and semantic similarity metrics, clincal scoring, and operational performance metrics

Technical Skills

  • Machine Learning: PyTorch, TensorFlow/Keras, Scikit-learn, LightGBM, Hugging Face Transformers, Clinical NLP, LLM Evaluation
  • DevOps: Google Cloud Platform (GKE, Cloud Run), Kubernetes, Docker, FastAPI, GitHub Actions (CI/CD)
  • Data & Engineering: Python, Pandas, NumPy, SQL (PostgreSQL/MySQL), Seaborn, Bash

Education

  • MSc, Computer Science with Artificial Intelligence @ City St George’s, University of London
  • MBBS, Medicine @ Norwich Medical School, University of East Anglia

Clinical Experience

Clinical Research

  • Lacertus syndrome and its surgical management using WALANT - our first 12 cases (Research Poster)
  • Giant trichoblastic carcinoma initially misdiagnosed as basal cell carcinoma (Case Report)

Audit Cycles

  • Head and Neck Surgery, Integrated Care Pathway Surgical Proforma Audit
  • Plastic Surgery, Free Flap Surgical Outcomes Audit

Healthcare Data Skills

  • Clinical Informatics: EHR Systems (ICE, SystmOne, MediViewer, EPMA), NEWS2, GDPR
  • Clinical Research: Audit Methodology, Literature Review, Critical Appraisal, Manuscript Preparation

Archives

Pinned Loading

  1. Clinical-Entity-Extraction-Validation-System Clinical-Entity-Extraction-Validation-System Public

    Clinical NLP system converting ICU progress notes to structured entity outputs using rule-based extraction and fine-tuned BioClinicalBERT validation

    Jupyter Notebook 3

  2. Time-Series-ICU-Patient-Deterioration-Predictor Time-Series-ICU-Patient-Deterioration-Predictor Public

    Early ICU deterioration detection system combining LightGBM and Temporal CNN (TCN) for multi-dimensional clinical risk modeling

    Python 2

  3. breast-cancer-ml-workflow breast-cancer-ml-workflow Public

    Scikit-learn binary classification workflow using the Breast Cancer Wisconsin dataset, comparing logistic regression with a baseline model to predict tumour malignancy from cell-nuclei measurements.

    Jupyter Notebook 1