File Structure

model

• ./model_data contains model training with only PCAWG labeled data (using whether chromothripsis occurs in a chromosome as Y label).
• ./label_model_data contains model training with PCAWG labeled data and part of TCGA data.
  which can be surely labelled by the author of this research (using whether shatterSeek output aligns with manual inspection as Y label)
• ./model_extended_data contains model training with PCAWG labeled data and part of TCGA data, the same as the dataset used in label_model (but using whether chromothripsis occurs in a chromosome as Y label)
• ./semi_supervised_learning contains model training through supervised learning (data: PCAWG data + 50 TCGA cases/chromosomes which ShatterSeek regarded as negative falsely due to the criteria related to CNV), and through semi_supervised learning (data: PCAWG data + all TCAG data)

data

PCAWG data distribution: Chromothripsis-Pos 1987 chromosomes, Chromothripsis_Neg 861 chromosomes.

TCGA data distribution: [According to ShatterSeek output]

• High Confidence: 637 (2.86%)
• Low Confidence: 326 (1.46%)
• Not Significant: 21324 (95.68%)