ModelDBRepository/247719
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The models for the paper:<p>
Vasalou C, Henson MA (2010) A multiscale model to investigate
circadian rhythmicity of pacemaker neurons in the suprachiasmatic
nucleus.
<a href="http://dx.doi.org/10.1371/journal.pcbi.1000706">PLoS Comput Biol</a> 6:e1000706
[<a href="https://www.ncbi.nlm.nih.gov/pubmed?holding=modeldb&term=20300645">PubMed</a>]
<p/>
are available at the biomodels website:<p/>
<a href="https://www.ebi.ac.uk/biomodels/BIOMD0000000246#Files">https://www.ebi.ac.uk/biomodels/BIOMD0000000246#Files</a>
<p/>
<p/> Example: To recreate a few traces in COPASI from figure 2 in
the paper: import the downloaded xml (SBML) file into COPASI, change
the Duration to more than 100 hours (172 here) and the interval
point to 0.1 hours. The more than 100 hours lets the model
stabilize. Create a few graphs (use Plots under Output
specifications). Running (click Run under Time Course window - see
below image)) creates the graphs.<p/>
<img src="./screenshot1.png" alt="screenshot 1" width="550"><p/>
(Above image of COPASI simulator ready to run.)
<img src="./screenshot2.png" alt="screenshot 2" width="550"><p/>
(Above traces are I Na, g K, Ca, and firing rate plotted vs hours. Each cycle is 24 hours.)
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