diff --git a/src/global_asm.rs b/src/global_asm.rs
index 1daf428acf..b149885778 100644
--- a/src/global_asm.rs
+++ b/src/global_asm.rs
@@ -120,9 +120,15 @@ fn codegen_global_asm_inner<'tcx>(
                         }
 
                         let symbol = tcx.symbol_name(instance);
+                        let symbol_name = if tcx.sess.target.is_like_darwin {
+                            format!("_{}", symbol.name)
+                        } else {
+                            symbol.name.to_owned()
+                        };
+
                         // FIXME handle the case where the function was made private to the
                         // current codegen unit
-                        global_asm.push_str(&escape_symbol_name(tcx, symbol.name, span));
+                        global_asm.push_str(&escape_symbol_name(tcx, &symbol_name, span));
                     }
                     GlobalAsmOperandRef::SymStatic { def_id } => {
                         if cfg!(not(feature = "inline_asm_sym")) {
@@ -134,7 +140,13 @@ fn codegen_global_asm_inner<'tcx>(
 
                         let instance = Instance::mono(tcx, def_id);
                         let symbol = tcx.symbol_name(instance);
-                        global_asm.push_str(&escape_symbol_name(tcx, symbol.name, span));
+                        let symbol_name = if tcx.sess.target.is_like_darwin {
+                            format!("_{}", symbol.name)
+                        } else {
+                            symbol.name.to_owned()
+                        };
+
+                        global_asm.push_str(&escape_symbol_name(tcx, &symbol_name, span));
                     }
                 }
             }
diff --git a/src/inline_asm.rs b/src/inline_asm.rs
index 8f1bb0b471..044243f2c7 100644
--- a/src/inline_asm.rs
+++ b/src/inline_asm.rs
@@ -574,7 +574,13 @@ impl<'tcx> InlineAssemblyGenerator<'_, 'tcx> {
                         CInlineAsmOperand::Const { ref value } => {
                             generated_asm.push_str(value);
                         }
-                        CInlineAsmOperand::Symbol { ref symbol } => generated_asm.push_str(symbol),
+                        CInlineAsmOperand::Symbol { ref symbol } => {
+                            if binary_format == BinaryFormat::Macho {
+                                generated_asm.push('_');
+                            }
+
+                            generated_asm.push_str(symbol);
+                        }
                     }
                 }
             }