diff --git a/.github/workflows/root-ci-config/null_build_check.py b/.github/workflows/root-ci-config/null_build_check.py
index c80a3d14f7cb3..6741b3cdff4c2 100644
--- a/.github/workflows/root-ci-config/null_build_check.py
+++ b/.github/workflows/root-ci-config/null_build_check.py
@@ -52,6 +52,8 @@
     "*/CMakeFiles/generate.stamp",
     # ctest leftovers, in case the tree has been tested before.
     "Testing/*",
+    # Python caching
+    "*/__pycache__/*",
 )
 
 # ExternalProject keeps git clones of externals in the build tree.