diff --git a/s2a/src/main/java/io/grpc/s2a/internal/handshaker/SslContextFactory.java b/s2a/src/main/java/io/grpc/s2a/internal/handshaker/SslContextFactory.java
index 5d4ef9eb667..e586b51a76f 100644
--- a/s2a/src/main/java/io/grpc/s2a/internal/handshaker/SslContextFactory.java
+++ b/s2a/src/main/java/io/grpc/s2a/internal/handshaker/SslContextFactory.java
@@ -92,6 +92,9 @@ static SslContext createForClient(
         S2ATrustManager.createForClient(stub, targetName, localIdentity));
     sslContextBuilder.option(
         OpenSslContextOption.PRIVATE_KEY_METHOD, S2APrivateKeyMethod.create(stub, localIdentity));
+    sslContextBuilder.option(
+        OpenSslContextOption.GROUPS,
+        new String[] {"X25519MLKEM768", "x25519", "secp256r1", "secp384r1", "secp521r1"});
 
     SslContext sslContext = sslContextBuilder.build();
     SSLSessionContext sslSessionContext = sslContext.sessionContext();
diff --git a/s2a/src/test/java/io/grpc/s2a/IntegrationTest.java b/s2a/src/test/java/io/grpc/s2a/IntegrationTest.java
index 1d3568808c6..b816ae53670 100644
--- a/s2a/src/test/java/io/grpc/s2a/IntegrationTest.java
+++ b/s2a/src/test/java/io/grpc/s2a/IntegrationTest.java
@@ -44,6 +44,7 @@
 import io.grpc.testing.protobuf.SimpleResponse;
 import io.grpc.testing.protobuf.SimpleServiceGrpc;
 import io.netty.handler.ssl.ClientAuth;
+import io.netty.handler.ssl.OpenSslContextOption;
 import io.netty.handler.ssl.OpenSslSessionContext;
 import io.netty.handler.ssl.SslContext;
 import io.netty.handler.ssl.SslContextBuilder;
@@ -253,4 +254,41 @@ public void unaryRpc(SimpleRequest request, StreamObserver<SimpleResponse> obser
       observer.onCompleted();
     }
   }
+
+  @Test
+  public void clientCommunicateWithPqcRequiredServer_succeeds() throws Exception {
+    ClassLoader classLoader = IntegrationTest.class.getClassLoader();
+    SslContextBuilder serverSslContextBuilder =
+        SslContextBuilder.forServer(
+            classLoader.getResourceAsStream("cert_chain_ec.pem"),
+            classLoader.getResourceAsStream("leaf_key_ec.pem"));
+    SslContext serverSslContext =
+        GrpcSslContexts.configure(serverSslContextBuilder, SslProvider.OPENSSL)
+            .protocols("TLSv1.3")
+            .trustManager(classLoader.getResourceAsStream("root_cert_ec.pem"))
+            .clientAuth(ClientAuth.REQUIRE)
+            .option(OpenSslContextOption.GROUPS, new String[] {"X25519MLKEM768"})
+            .build();
+
+    Server pqcServer =
+        NettyServerBuilder.forPort(0)
+            .addService(new SimpleServiceImpl())
+            .sslContext(serverSslContext)
+            .build()
+            .start();
+    int pqcServerPort = pqcServer.getPort();
+    String pqcServerAddress = "localhost:" + pqcServerPort;
+
+    try {
+      ChannelCredentials credentials =
+          S2AChannelCredentials.newBuilder(s2aAddress, InsecureChannelCredentials.create())
+              .setLocalSpiffeId("test-spiffe-id").build();
+      ManagedChannel channel = Grpc.newChannelBuilder(pqcServerAddress, credentials).build();
+
+      assertThat(doUnaryRpc(channel)).isTrue();
+    } finally {
+      pqcServer.shutdown();
+      pqcServer.awaitTermination(10, SECONDS);
+    }
+  }
 }