diff --git a/packages/react-aria-components/test/ListBox.test.js b/packages/react-aria-components/test/ListBox.test.js
index 026eea5d36a..ef72826d104 100644
--- a/packages/react-aria-components/test/ListBox.test.js
+++ b/packages/react-aria-components/test/ListBox.test.js
@@ -2523,6 +2523,39 @@ describe('keyboard modifier keys', () => {
       expect(document.activeElement).toBe(options[1]);
     });
 
+    it('does not activate an element focused during selection with Enter', async () => {
+      let onClick = jest.fn();
+      let triggerRef = React.createRef();
+      let {getByRole} = render(
+        <>
+          <button ref={triggerRef} onClick={onClick}>
+            Trigger
+          </button>
+          <ListBox
+            aria-label="Favorite Animal"
+            selectionMode="single"
+            onSelectionChange={() => {
+              // oxlint-disable-next-line rsp-rules/act-events-test
+              triggerRef.current.focus();
+            }}>
+            <ListBoxItem id="cat">Cat</ListBoxItem>
+            <ListBoxItem id="dog">Dog</ListBoxItem>
+          </ListBox>
+        </>
+      );
+
+      let options = within(getByRole('listbox')).getAllByRole('option');
+      act(() => options[0].focus());
+
+      // Selection moves focus to the trigger during keydown. Unless Enter's default is
+      // prevented, the browser dispatches the activation click to the newly focused
+      // element.
+      await user.keyboard('{Enter}');
+
+      expect(triggerRef.current).toHaveFocus();
+      expect(onClick).not.toHaveBeenCalled();
+    });
+
     describe('multiple selection, replace behavior', () => {
       it('replaces selection as focus moves with arrow keys', async () => {
         let onSelectionChange = jest.fn();
diff --git a/packages/react-aria/src/interactions/usePress.ts b/packages/react-aria/src/interactions/usePress.ts
index 517c8019b90..8b847ac1848 100644
--- a/packages/react-aria/src/interactions/usePress.ts
+++ b/packages/react-aria/src/interactions/usePress.ts
@@ -391,7 +391,7 @@ export function usePress(props: PressHookProps): PressResult {
           isValidKeyboardEvent(e.nativeEvent, e.currentTarget as Element) &&
           nodeContains(e.currentTarget as Element, getEventTarget(e) as Element)
         ) {
-          if (shouldPreventDefaultKeyboard(getEventTarget(e) as Element, e.key)) {
+          if (shouldPreventDefaultKeyboard(getEventTarget(e) as Element, e)) {
             e.preventDefault();
           }
 
@@ -497,7 +497,7 @@ export function usePress(props: PressHookProps): PressResult {
 
     let onKeyUp = (e: KeyboardEvent) => {
       if (state.isPressed && state.target && isValidKeyboardEvent(e, state.target)) {
-        if (shouldPreventDefaultKeyboard(getEventTarget(e) as Element, e.key)) {
+        if (shouldPreventDefaultKeyboard(getEventTarget(e) as Element, e)) {
           e.preventDefault();
         }
 
@@ -1161,9 +1161,13 @@ function shouldPreventDefaultUp(target: Element) {
   return true;
 }
 
-function shouldPreventDefaultKeyboard(target: Element, key: string) {
-  // Don't prevent the contextmenu shortcut on mac.
-  if (isMac() && key === 'Enter') {
+function shouldPreventDefaultKeyboard(
+  target: Element,
+  event: Pick<KeyboardEvent, 'key' | 'ctrlKey'>
+) {
+  let {key} = event;
+  // Don't prevent the contextmenu shortcut (Control + Enter) on mac.
+  if (isMac() && key === 'Enter' && event.ctrlKey) {
     return false;
   }
 
diff --git a/packages/react-aria/test/interactions/usePress.test.js b/packages/react-aria/test/interactions/usePress.test.js
index 1f944d2d9ca..e54662e0f27 100644
--- a/packages/react-aria/test/interactions/usePress.test.js
+++ b/packages/react-aria/test/interactions/usePress.test.js
@@ -3173,6 +3173,29 @@ describe('usePress', function () {
       ]);
     });
 
+    it('should prevent default on Enter on macOS', function () {
+      let {getByText} = render(<Example />);
+      using spy = jest.spyOn(window.navigator, 'platform', 'get').mockImplementation(() => 'Mac');
+
+      let el = getByText('test');
+      let allowDefault = fireEvent.keyDown(el, {key: 'Enter'});
+      expect(allowDefault).toBe(false);
+      allowDefault = fireEvent.keyUp(el, {key: 'Enter'});
+      expect(allowDefault).toBe(false);
+      spy.mockRestore();
+    });
+
+    it('should not prevent default on Control + Enter on macOS so the context menu can open', function () {
+      let {getByText} = render(<Example />);
+      using spy = jest.spyOn(window.navigator, 'platform', 'get').mockImplementation(() => 'Mac');
+
+      let el = getByText('test');
+      let allowDefault = fireEvent.keyDown(el, {key: 'Enter', ctrlKey: true});
+      expect(allowDefault).toBe(true);
+      fireEvent.keyUp(el, {key: 'Enter', ctrlKey: true});
+      spy.mockRestore();
+    });
+
     it('should handle when focus moves between keydown and keyup', function () {
       let events = [];
       let addEvent = e => events.push(e);