diff --git a/bin/combine_annotations.py b/bin/combine_annotations.py index cef2f2da..1bc4cf01 100755 --- a/bin/combine_annotations.py +++ b/bin/combine_annotations.py @@ -14,15 +14,14 @@ logger = get_logger(filename=Path(__file__).stem) def read_and_preprocess(path: Path): - # We design input fastas from intermediate steps to be named like: "input_fasta___some_information_annotation_file.tsv" input_fasta = input_fasta_from_filepath(path) try: df = pd.read_csv(path) - df[FASTA_COLUMN] = input_fasta # Add input_fasta column + df[FASTA_COLUMN] = input_fasta return df except Exception as e: logger.error(f"Error loading DataFrame for input_fasta {input_fasta}: {str(e)}") - return pd.DataFrame() # Return an empty DataFrame in case of error + return pd.DataFrame() def input_fasta_from_filepath(file_path: Path): return file_path.stem.split("___")[0] @@ -51,7 +50,6 @@ def count_motifs(gene_faa, motif="(C..CH)", genes_faa_dict=None): for seq in read_sequence(gene_faa, format="fasta"): if seq.metadata["id"] not in genes_faa_dict: genes_faa_dict[seq.metadata["id"]] = {} - genes_faa_dict[seq.metadata["id"]]["heme_regulatory_motif_count"] = len(list(seq.find_with_regex(motif))) return genes_faa_dict @@ -61,7 +59,6 @@ def set_gene_data(gene_faa, genes_faa_dict=None): for seq in read_sequence(gene_faa, format="fasta"): if seq.metadata["id"] not in genes_faa_dict: genes_faa_dict[seq.metadata["id"]] = {} - split_label = seq.metadata["id"].split("_") gene_position = split_label[-1] start_position, end_position, strandedness = seq.metadata["description"].split("#")[1:4] @@ -84,16 +81,13 @@ def organize_columns(df, special_columns=None): special_columns = [] base_columns = ['query_id', FASTA_COLUMN, "scaffold", 'gene_number', 'start_position', 'stop_position', 'strandedness', 'rank'] base_columns = [col for col in base_columns if col in df.columns] - kegg_columns = sorted([col for col in df.columns if col.startswith('kegg_')], key=lambda x: (x != 'kegg_id', x)) other_columns = [col for col in df.columns if col not in base_columns + kegg_columns + special_columns] - db_prefixes = set(col.split('_')[0] for col in other_columns) sorted_other_columns = [] for prefix in db_prefixes: prefixed_columns = sorted([col for col in other_columns if col.startswith(prefix + '_')], key=lambda x: (x != f"{prefix}_id", x)) sorted_other_columns.extend(prefixed_columns) - final_columns_order = base_columns + kegg_columns + sorted_other_columns + special_columns return df[final_columns_order] @@ -107,11 +101,10 @@ def combine_annotations(annotations_dir, genes_dir, output, threads): annotations = Path(annotations_dir).glob("*") genes_faa = Path(genes_dir).glob("*") with ThreadPoolExecutor(max_workers=threads) as executor: - # futures = [executor.submit(read_and_preprocess, input_fasta, path) for input_fasta, path in input_fastas_and_paths] futures = [executor.submit(read_and_preprocess, Path(path)) for path in annotations] data_frames = [future.result() for future in as_completed(futures)] - combined_data = pd.concat(data_frames, ignore_index=True) + combined_data = pd.concat([df for df in data_frames if not df.empty], ignore_index=True) if genes_faa: genes_faa_dict = dict() for gene_path in genes_faa: @@ -119,17 +112,9 @@ def combine_annotations(annotations_dir, genes_dir, output, threads): genes_faa_dict count_motifs(gene_path, "(C..CH)", genes_faa_dict=genes_faa_dict) set_gene_data(gene_path, genes_faa_dict) - df = pd.DataFrame.from_dict(genes_faa_dict, orient='index') - columns = [col for col in df.columns.tolist() if col != FASTA_COLUMN] - combined_data = combined_data.drop(columns=columns, errors='ignore') - df.index.name = 'query_id' - df = df.rename(columns={FASTA_COLUMN: FASTA_COLUMN+"2"}) - - # we use outer to get any genes that don't have hits - combined_data = pd.merge(combined_data, df, how="outer", on="query_id") - combined_data[FASTA_COLUMN] = combined_data[FASTA_COLUMN].fillna("") - mask = combined_data[FASTA_COLUMN] != "" - combined_data[FASTA_COLUMN] = combined_data[FASTA_COLUMN].where(mask, other=combined_data[FASTA_COLUMN+"2"]) + df = pd.DataFrame.from_dict(genes_faa_dict, orient='index').reset_index().rename(columns={'index': 'query_id'}) + combined_data = combined_data.drop(columns=df.columns.difference(["query_id", "scaffold", FASTA_COLUMN]), errors='ignore') + combined_data = pd.merge(combined_data, df, how="outer", on=["query_id", FASTA_COLUMN]) combined_data = convert_bit_scores_to_numeric(combined_data) diff --git a/bin/distill.py b/bin/distill.py index 856a958b..885bf475 100755 --- a/bin/distill.py +++ b/bin/distill.py @@ -25,7 +25,6 @@ DISTILATE_SORT_ORDER_COLUMNS = [COL_HEADER, COL_SUBHEADER, COL_MODULE, COL_GENE_ID] EXCEL_MAX_CELL_SIZE = 32767 -FASTA_COLUMN = os.getenv('FASTA_COLUMN', 'input_fasta') DISTILL_DIR = Path(__file__).parent / "assets/forms/distill_sheets" @@ -34,21 +33,107 @@ def check_columns(data, logger): missing = [i for i in ID_EXPR_DICT if i not in data.columns] logger.info("Note: the following id fields " f"were not in the annotations file and are not being used: {missing}," - f" but these are {functions}") + f" but these are {list(functions.keys())}") -def make_genome_summary(annotations, genome_summary_frame: pl.LazyFrame, logger, groupby_column=FASTA_COLUMN): - rules_col = "rules" - if rules_col not in genome_summary_frame.collect_schema().names(): - genome_summary_frame = genome_summary_frame.with_columns( - pl.lit(None).cast(pl.String).alias(rules_col) - ) - genome_summary_frame = genome_summary_frame.with_columns( - pl.when(pl.col(rules_col).is_not_null()) - .then(pl.col(rules_col)) - .otherwise(pl.col("gene_id")) - .alias(rules_col) - ) +def get_ids_from_annotations_by_row(data): + functions = {i:j for i,j in FUNCTION_DICT.items() if i in data.columns} + out = data.apply(lambda x: {i for k, v in functions.items() if not pd.isna(x[k]) + for i in v(str(x[k])) if not pd.isna(i)}, axis=1) + return out + + +def get_ids_from_annotations_all(data): + data = get_ids_from_annotations_by_row(data) + data.apply(list) + out = Counter(chain(*data.values)) + return out + + +def fill_genome_summary_frame(annotations, genome_summary_frame, groupby_column, logger): + genome_summary_id_sets = [set([str(k).strip() for k in j.split(',')]) for j in genome_summary_frame[COL_GENE_ID]] + logger.info(f"Genome summary ID sets: {genome_summary_id_sets}") + + def fill_a_frame(frame: pd.DataFrame): + id_dict = get_ids_from_annotations_all(frame) + logger.info(f"ID dictionary for {frame.name}: {id_dict}") + + counts = list() + for set_ in genome_summary_id_sets: + identifier_count = 0 + for gene_id in set_: + # Try matching with and without '.hmm' + matching_keys = [key for key in id_dict.keys() if gene_id == key or key.startswith(gene_id + ".")] + for key in matching_keys: + identifier_count += id_dict[key] + counts.append(identifier_count) + # logger.info(f"Counts for {frame.name}: {counts}") + + return pd.Series(counts, index=genome_summary_frame.index) + + counts = annotations.groupby(groupby_column, sort=False)[annotations.columns].apply(fill_a_frame) + genome_summary_frame = pd.concat([genome_summary_frame, counts.T], axis=1) + + return genome_summary_frame + + +def fill_genome_summary_frame_gene_names(annotations, genome_summary_frame, groupby_column, logger): + genome_summary_id_sets = [set([k.strip() for k in j.split(',')]) for j in genome_summary_frame[COL_GENE_ID]] + for genome, frame in annotations.groupby(groupby_column, sort=False): + # make dict of identifiers to gene names + id_gene_dict = defaultdict(list) + for gene, ids in get_ids_from_annotations_by_row(frame).items(): + for id_ in ids: + id_gene_dict[id_].append(gene) + # fill in genome summary_frame + values = list() + for id_set in genome_summary_id_sets: + this_value = list() + for id_ in id_set: + this_value += id_gene_dict[id_] + values.append(','.join(this_value)) + genome_summary_frame[genome] = values + return genome_summary_frame + + +def summarize_rrnas(rrnas_df, groupby_column="input_fasta"): + genome_rrna_dict = dict() + for genome, frame in rrnas_df.groupby(groupby_column): + genome_rrna_dict[genome] = Counter(frame['type']) + row_list = list() + for rna_type in RRNA_TYPES: + row = [rna_type, '%s ribosomal RNA gene' % rna_type.split()[0], 'rRNA', 'rRNA', '', ''] + for genome, rrna_dict in genome_rrna_dict.items(): + row.append(genome_rrna_dict[genome].get(rna_type, 0)) + row_list.append(row) + rrna_frame = pd.DataFrame(row_list, columns=FRAME_COLUMNS + list(genome_rrna_dict.keys())) + return rrna_frame + + +def make_genome_summary(annotations, genome_summary_frame, logger, groupby_column="input_fasta"): + + summary_frames = list() + # get ko summaries + summary_frames.append(fill_genome_summary_frame(annotations, genome_summary_frame.copy(), groupby_column, logger)) + + # merge summary frames + summarized_genomes = pd.concat(summary_frames, sort=False) + return summarized_genomes + + +def split_column_str(names): + if len(names) < EXCEL_MAX_CELL_SIZE: + return [names] + out = [''] + name_list = names.split(',') + j = 0 + for i in name_list: + if len(out[j]) + len(i) + 1 < EXCEL_MAX_CELL_SIZE: + out[j] = ','.join([out[j], i]) + else: + j += 1 + out += [''] + return out df = evaluate_rules_on_anno( rules=genome_summary_frame, @@ -66,12 +151,25 @@ def make_genome_summary(annotations, genome_summary_frame: pl.LazyFrame, logger, df = genome_summary_frame.collect().join(df, on="gene_id", how="left") - df = df.drop(OPTIONAL_COLUMNS, strict=False) +def write_summarized_genomes_to_xlsx(summarized_genomes, output_file, extra_frames=tuple()): + # turn all this into an xlsx + with pd.ExcelWriter(output_file) as writer: + for sheet, frame in summarized_genomes.groupby(COL_SHEET, sort=False): + frame = frame.sort_values(DISTILATE_SORT_ORDER_COLUMNS) + frame = frame.drop([COL_SHEET], axis=1) + gene_columns = list(set(frame.columns) - set(CONSTANT_DISTILLATE_COLUMNS)) + if gene_columns: + split_genes = pd.concat([split_names_to_long(frame[i].astype(str)) for i in gene_columns], axis=1) + frame = pd.concat([frame[CONSTANT_DISTILLATE_COLUMNS], split_genes], axis=1) + frame.to_excel(writer, sheet_name=sheet, index=False) + for extra_frame in extra_frames: + if extra_frame is not None and not extra_frame.empty: + extra_frame.to_excel(writer, sheet_name=extra_frame[COL_HEADER].iloc[0], index=False) return df # TODO: add assembly stats like N50, longest contig, total assembled length etc -def make_genome_stats(annotations: pl.DataFrame, rrna_frame: pl.DataFrame = None, trna_frame: pl.DataFrame = None, quast_frame: pl.DataFrame = None, groupby_column: str = FASTA_COLUMN): +def make_genome_stats(annotations, rrna_frame=None, trna_frame=None, quast_frame=None, groupby_column="input_fasta"): rows = list() columns = ['genome'] if 'scaffold' in annotations.columns: @@ -99,23 +197,15 @@ def make_genome_stats(annotations: pl.DataFrame, rrna_frame: pl.DataFrame = None meta_cols = RRNA_COLUMNS sample_cols = [c for c in rrna_frame.columns if c not in meta_cols] - # group_by gene_id, sum sample columns - df_rrna = ( - rrna_frame - .group_by("gene_id") - .agg([pl.col(c).sum().alias(c) for c in sample_cols]) - ) + df_rrna = rrna_frame.groupby("gene_id")[sample_cols].sum() - # transpose: rows -> genomes (samples), columns -> gene_id - # This creates a "genome" column from original sample column names - df_rrna = df_rrna.transpose( - include_header=True, - header_name="genome", # new first column name - column_names="gene_id", # column headers come from gene_id values - ) + # Transpose so samples become rows and genes become columns + df_rrna = df_rrna.T.reset_index() - genome_stats = genome_stats.join(df_rrna, on="genome", how="inner") - assert genome_stats.shape[0] == df_rrna.shape[0], "genomes from annotation file don't map to rrna file" + # Rename the index column to input_fasta (or whatever you want) + df_rrna = df_rrna.rename(columns={"index": "genome"}) + df_rrna.columns.name = None + genome_stats = pd.merge(genome_stats, df_rrna, how="outer", on="genome") if trna_frame is not None: meta_cols = TRNA_COLUMNS @@ -147,16 +237,19 @@ def make_genome_stats(annotations: pl.DataFrame, rrna_frame: pl.DataFrame = None @click.command() @click.option("-i", "--input_file", required=True, help="Annotations path") # @click.option("-o", "--output_dir", required=True, help="Directory to write summarized genomes") -@click.option("--rrna_path", help="rRNA output from annotation") -@click.option("--trna_path", help="tRNA output from annotation") -@click.option("--quast_path", help="Quast summary TSV from the quast step") +@click.option("--rrna_path", help="rRNA output from annotation", default=None, type=click.Path(exists=True)) +@click.option("--trna_path", help="tRNA output from annotation", default=None, type=click.Path(exists=True)) +@click.option("--quast_path", help="Quast summary TSV from the quast step", default=None, type=click.Path(exists=True)) @click.option("--groupby_column", help="Column from annotations to group as organism units", - default=FASTA_COLUMN) + default="input_fasta", type = click.STRING) @click.option("--distil_topics", default="default", help="Default distillates topics to run.") @click.option("--distil_ecosystem", default="eng_sys,ag", help="Default distillates ecosystems to run.") -@click.option("--custom_distillate", default=[], callback=validate_comma_separated, help="Custom distillate forms to add your own modules, comma separated. ") -def distill(input_file, rrna_path=None, trna_path=None, quast_path=None, groupby_column=FASTA_COLUMN, distil_topics=None, distil_ecosystem=None, - custom_distillate=None): +@click.option("--custom_distillate", default="", callback=validate_comma_separated, help="Custom distillate forms to add your own modules, comma separated. ") +@click.option("--distillate_gene_names", is_flag=True, + show_default=True, default=False, + help="Give names of genes instead of counts in genome metabolism summary") +def distill(input_file, rrna_path, trna_path, quast_path, groupby_column, distil_topics, distil_ecosystem, + custom_distillate, distillate_gene_names): """Summarize metabolic content of annotated genomes""" # read in data @@ -170,24 +263,20 @@ def distill(input_file, rrna_path=None, trna_path=None, quast_path=None, groupby # Check the columns are present check_columns(annotations, logger) - if trna_path is None: - trna_frame = None - else: - trna_frame = pl.read_csv(trna_path, separator='\t') - if rrna_path is None: - rrna_frame = None - else: - rrna_frame = pl.read_csv(rrna_path, separator='\t') - # Check NF DRAM didn't pass an empty sheet to signal no tRNAs or rRNAs - if rrna_frame.is_empty(): - rrna_frame = None - if trna_frame.is_empty(): - trna_frame = None - - if quast_path is None: - quast_frame = None - else: - quast_frame = pl.read_csv(quast_path, separator='\t') + trna_frame = None + rrna_frame = None + if all([v is not None for v in [trna_path, rrna_path]]): + trna_frame = pd.read_csv(trna_path, sep='\t') + rrna_frame = pd.read_csv(rrna_path, sep='\t') + if any(v.dropna(how="all").empty for v in [trna_frame, rrna_frame]): + trna_frame = None + rrna_frame = None + + quast_frame = None + if quast_path is not None: + quast_frame = pd.read_csv(quast_path, sep='\t') + if quast_frame.dropna(how="all").empty: + quast_frame = None distil_sheets_names = [] if "default" in distil_topics: @@ -240,8 +329,8 @@ def distill(input_file, rrna_path=None, trna_path=None, quast_path=None, groupby logger.info('Retrieved distillate genome summary form') # make genome stats - genome_stats = make_genome_stats(annotations, rrna_frame, trna_frame, quast_frame=quast_frame, groupby_column=groupby_column) - genome_stats.write_csv('genome_stats.tsv', separator='\t') + genome_stats = make_genome_stats(annotations, rrna_frame, trna_frame, quast_frame, groupby_column=groupby_column) + genome_stats.to_csv('genome_stats.tsv', sep='\t', index=None) logger.info('Calculated genome statistics') # make genome metabolism summary diff --git a/conf/base.config b/conf/base.config index 1e69ac57..460af8ca 100644 --- a/conf/base.config +++ b/conf/base.config @@ -59,8 +59,14 @@ process { withLabel:error_ignore { errorStrategy = 'ignore' } + withLabel:error_retry { errorStrategy = 'retry' maxRetries = 2 } + + withName: 'DRAM:ANNOTATE:CALL:.*|DRAM:ANNOTATE:DB_SEARCH:.*|DRAM:ANNOTATE:QC:COLLECT_RNA:.*' { + array = params.array_size + } + } diff --git a/conf/modules.config b/conf/modules.config index 1613b337..91471656 100644 --- a/conf/modules.config +++ b/conf/modules.config @@ -191,6 +191,7 @@ process { ] } withName: SUMMARIZE { + ext.args = { "--groupby_column ${params.CONSTANTS.FASTA_COLUMN}" } publishDir = [ [ path: "${params.outdir}/SUMMARIZE", diff --git a/modules/local/distill/distill.nf b/modules/local/distill/distill.nf index 1e919175..86ee9fa6 100644 --- a/modules/local/distill/distill.nf +++ b/modules/local/distill/distill.nf @@ -7,26 +7,35 @@ process SUMMARIZE { container "community.wave.seqera.io/library/python_click_polars_pyarrow_pruned:00822989eabb8b47" input: - path( ch_combined_annotations, stageAs: "raw-annotations.tsv" ) - path( ch_rrna_collected, stageAs: "rrna_combined.tsv" ) - path( ch_trna_collected, stageAs: "trna_combined.tsv" ) - path( ch_quast_stats ) - val( distill_topic ) - val( distill_ecosystem ) - val( distill_custom ) + path combined_annotations + path rrna_collected + path trna_collected + path quast_stats + val distill_topic + val distill_ecosystem + val distill_custom output: - path( "metabolism_summary.xlsx" ), emit: distillate - path( "*.log" ), emit: log - path( "summarized_genomes.tsv" ), emit: summarized_genomes - path( "genome_stats.tsv" ), emit: genome_stats + path "metabolism_summary.xlsx", emit: distillate + path "*.log", emit: log + path "summarized_genomes.tsv", emit: summarized_genomes + path "genome_stats.tsv", emit: genome_stats script: - """ - # export constants for script - export FASTA_COLUMN="${params.CONSTANTS.FASTA_COLUMN}" - - distill.py -i ${ch_combined_annotations} --rrna_path '${ch_rrna_collected}' --trna_path '${ch_trna_collected}' --distil_topics "${distill_topic}" --distil_ecosystem "${distill_ecosystem}" --custom_distillate "${distill_custom}" --quast_path '${ch_quast_stats}' + def args = task.ext.args ?: "" + def rrna = rrna_collected ? "--rrna_path ${rrna_collected}" : "" + def trna = trna_collected ? "--trna_path ${trna_collected}" : "" + def quast = quast_stats ? "--quast_path ${quast_stats}" : "" """ + distill.py \ + -i ${combined_annotations} \ + ${rrna} \ + ${trna} \ + ${quast} \ + --distil_topics "${distill_topic}" \ + --distil_ecosystem "${distill_ecosystem}" \ + --custom_distillate "${distill_custom}" \ + ${args} + """ } diff --git a/nextflow.config b/nextflow.config index b6426629..b9fbca53 100644 --- a/nextflow.config +++ b/nextflow.config @@ -166,7 +166,8 @@ params { /* Process Options */ - queue_size = 10 + array_size = 10 + // queue_size = 10 // This is the resource requirements for a single process // Not the limit to the total resources available to the pipeline // Up to queue_size processes can run in parallel, of various sizes diff --git a/subworkflows/local/annotate.nf b/subworkflows/local/annotate.nf index aa0abad1..011b7737 100644 --- a/subworkflows/local/annotate.nf +++ b/subworkflows/local/annotate.nf @@ -35,8 +35,8 @@ workflow ANNOTATE { ch_combined_annotations = default_sheet if (params.rename || call) { - fasta_name = ch_fasta.map { it[0] } - fasta_files = ch_fasta.map { it[1] } + fasta_name = ch_fasta.map { it-> it[0] } + fasta_files = ch_fasta.map { it -> it[1] } n_fastas = file("$params.input_fasta/${params.fasta_fmt}").size() } @@ -50,10 +50,7 @@ workflow ANNOTATE { // we use flatten here to turn a list back into a channel renamed_fasta_paths = RENAME_FASTA.out.renamed_fasta_paths.flatten() // we need to recreate the fasta channel with the renamed fasta files - ch_fasta = renamed_fasta_paths.map { - fasta_name = it.getBaseName() - tuple(fasta_name, it) - } + ch_fasta = renamed_fasta_paths.map { it -> [ it.getBaseName(), it ] } } ch_quast_stats = default_sheet diff --git a/subworkflows/local/call.nf b/subworkflows/local/call.nf index 74ae33d5..5f7c5dc6 100644 --- a/subworkflows/local/call.nf +++ b/subworkflows/local/call.nf @@ -38,13 +38,13 @@ workflow CALL { .set { ch_collected_faa } // Set the resulting list to ch_collected_faa // Collect all individual fasta to pass to quast - Channel.empty() + channel.empty() .mix( ch_called_genes ) .collect() .set { ch_collected_fna } // Collect all individual fasta to pass to quast - Channel.empty() + channel.empty() .mix( ch_filtered_fasta, ch_gene_gff ) .collect() .set { ch_collected_fasta } diff --git a/subworkflows/local/collect_rna.nf b/subworkflows/local/collect_rna.nf index d60b5106..8be50a05 100644 --- a/subworkflows/local/collect_rna.nf +++ b/subworkflows/local/collect_rna.nf @@ -33,7 +33,7 @@ workflow COLLECT_RNA { // If we didn't run call if (!call) { if (params.rrnas) { - Channel.fromPath("${params.rrnas}/*.tsv", checkIfExists: true) + channel.fromPath("${params.rrnas}/*.tsv", checkIfExists: true) .ifEmpty { exit 1, "If you specify --distill_ without --call, you must provide individual rRNA files generated with barrnap. Cannot find any files at: ${params.rrnas}\nNB: Path needs to follow pattern: path/to/directory" } .collect() .set { ch_collected_rRNAs } @@ -42,7 +42,7 @@ workflow COLLECT_RNA { } if (params.trnas) { // the user provided rrnas or trnas - Channel.fromPath("${params.trnas}/*.tsv", checkIfExists: true) + channel.fromPath("${params.trnas}/*.tsv", checkIfExists: true) .ifEmpty { exit 1, "If you specify --distill_ without --call, you must provide individual tRNA files generated with tRNAscan-SE. Cannot find any files at: ${params.trnas}\nNB: Path needs to follow pattern: path/to/directory" } .collect() .set { ch_collected_tRNAs } @@ -53,14 +53,14 @@ workflow COLLECT_RNA { TRNA_SCAN( ch_fasta ) ch_trna_scan = TRNA_SCAN.out.trna_scan_out // Collect all input_fasta formatted tRNA files - Channel.empty() + channel.empty() .mix( ch_trna_scan ) .collect() .set { ch_collected_tRNAs } // Run barrnap on each fasta to identify rRNAs RRNA_SCAN( ch_fasta ) ch_rrna_scan = RRNA_SCAN.out.rrna_scan_out - Channel.empty() + channel.empty() .mix( ch_rrna_scan ) .collect() .set { ch_collected_rRNAs } @@ -98,4 +98,4 @@ workflow COLLECT_RNA { ch_trna_collected ch_trna_combined -} \ No newline at end of file +} diff --git a/subworkflows/local/db_search.nf b/subworkflows/local/db_search.nf index 76d27dd1..71ccef7d 100644 --- a/subworkflows/local/db_search.nf +++ b/subworkflows/local/db_search.nf @@ -68,7 +68,7 @@ workflow DB_SEARCH { main: - DB_CHANNEL_SETUP( + DB_channel_SETUP( use_kegg, use_kofam, use_dbcan, @@ -111,23 +111,20 @@ workflow DB_SEARCH { if (!call) { - ch_called_proteins = Channel + ch_called_proteins = channel .fromPath(file(params.input_genes) / params.genes_fmt, checkIfExists: true) .ifEmpty { exit 1, "If you specify --annotate without --call, you must provide a fasta file of called genes using --input_genes. Cannot find any called gene fasta files matching: ${params.input_genes}\nNB: Path needs to follow pattern: path/to/directory/" } - .map { - input_fastaName = it.getBaseName() - tuple(input_fastaName, it) - } - + .map { it -> [ it.getBaseName(), it ] } + GENE_LOCS( ch_called_proteins) ch_gene_locs = GENE_LOCS.out.prodigal_locs_tsv n_fastas = file("$params.input_genes/${params.genes_fmt}").size() } - def formattedOutputChannels = channel.of() + def formattedOutputchannels = channel.of() // Here we will create mmseqs2 index files for each of the inputs if we are going to do a mmseqs2 database - if (DB_CHANNEL_SETUP.out.index_mmseqs) { + if (DB_channel_SETUP.out.index_mmseqs) { // Use MMSEQS2 to index each called genes protein file MMSEQS_INDEX( ch_called_proteins ) ch_mmseqs_query = MMSEQS_INDEX.out.mmseqs_index_out @@ -136,13 +133,13 @@ workflow DB_SEARCH { // KEGG annotation if (use_kegg) { ch_combined_query_locs_kegg = ch_mmseqs_query.join(ch_gene_locs) - MMSEQS_SEARCH_KEGG( ch_combined_query_locs_kegg, DB_CHANNEL_SETUP.out.ch_kegg_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, kegg_name ) + MMSEQS_SEARCH_KEGG( ch_combined_query_locs_kegg, DB_channel_SETUP.out.ch_kegg_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, kegg_name ) ch_kegg_unformatted = MMSEQS_SEARCH_KEGG.out.mmseqs_search_formatted_out SQL_KEGG(ch_kegg_unformatted, kegg_name, ch_sql_descriptions_db) ch_kegg_formatted = SQL_KEGG.out.sql_formatted_hits - formattedOutputChannels = formattedOutputChannels.mix(ch_kegg_formatted) + formattedOutputchannels = formattedOutputchannels.mix(ch_kegg_formatted) } // KOFAM annotation if (use_kofam) { @@ -161,13 +158,13 @@ workflow DB_SEARCH { // PFAM annotation if (use_pfam) { ch_combined_query_locs_pfam = ch_mmseqs_query.join(ch_gene_locs) - MMSEQS_SEARCH_PFAM( ch_combined_query_locs_pfam, DB_CHANNEL_SETUP.out.ch_pfam_mmseqs_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, pfam_name ) + MMSEQS_SEARCH_PFAM( ch_combined_query_locs_pfam, DB_channel_SETUP.out.ch_pfam_mmseqs_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, pfam_name ) ch_pfam_unformatted = MMSEQS_SEARCH_PFAM.out.mmseqs_search_formatted_out SQL_PFAM(ch_pfam_unformatted, pfam_name, ch_sql_descriptions_db) ch_pfam_formatted = SQL_PFAM.out.sql_formatted_hits - formattedOutputChannels = formattedOutputChannels.mix(ch_pfam_formatted) + formattedOutputchannels = formattedOutputchannels.mix(ch_pfam_formatted) } // dbCAN annotation if (use_dbcan) { @@ -202,10 +199,10 @@ workflow DB_SEARCH { // MMseqs ch_combined_query_locs_camper = ch_mmseqs_query.join(ch_gene_locs) - MMSEQS_SEARCH_CAMPER( ch_combined_query_locs_camper, DB_CHANNEL_SETUP.out.ch_camper_mmseqs_db, params.bit_score_threshold, params.rbh_bit_score_threshold, DB_CHANNEL_SETUP.out.ch_camper_mmseqs_list, camper_name ) + MMSEQS_SEARCH_CAMPER( ch_combined_query_locs_camper, DB_channel_SETUP.out.ch_camper_mmseqs_db, params.bit_score_threshold, params.rbh_bit_score_threshold, DB_channel_SETUP.out.ch_camper_mmseqs_list, camper_name ) ch_camper_mmseqs_formatted = MMSEQS_SEARCH_CAMPER.out.mmseqs_search_formatted_out - formattedOutputChannels = formattedOutputChannels.mix(ch_camper_mmseqs_formatted) + formattedOutputchannels = formattedOutputchannels.mix(ch_camper_mmseqs_formatted) } // FeGenie annotation if (use_fegenie) { @@ -224,19 +221,19 @@ workflow DB_SEARCH { // Methyl annotation if (use_methyl) { ch_combined_query_locs_methyl = ch_mmseqs_query.join(ch_gene_locs) - MMSEQS_SEARCH_METHYL( ch_combined_query_locs_methyl, DB_CHANNEL_SETUP.out.ch_methyl_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, methyl_name ) + MMSEQS_SEARCH_METHYL( ch_combined_query_locs_methyl, DB_channel_SETUP.out.ch_methyl_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, methyl_name ) ch_methyl_mmseqs_formatted = MMSEQS_SEARCH_METHYL.out.mmseqs_search_formatted_out - formattedOutputChannels = formattedOutputChannels.mix(ch_methyl_mmseqs_formatted) + formattedOutputchannels = formattedOutputchannels.mix(ch_methyl_mmseqs_formatted) } // CANT-HYD annotation if (use_canthyd) { // MMseqs ch_combined_query_locs_canthyd = ch_mmseqs_query.join(ch_gene_locs) - MMSEQS_SEARCH_CANTHYD( ch_combined_query_locs_canthyd, DB_CHANNEL_SETUP.out.ch_canthyd_mmseqs_db, params.bit_score_threshold, params.rbh_bit_score_threshold, DB_CHANNEL_SETUP.out.ch_canthyd_mmseqs_list, canthyd_name ) + MMSEQS_SEARCH_CANTHYD( ch_combined_query_locs_canthyd, DB_channel_SETUP.out.ch_canthyd_mmseqs_db, params.bit_score_threshold, params.rbh_bit_score_threshold, DB_channel_SETUP.out.ch_canthyd_mmseqs_list, canthyd_name ) ch_canthyd_mmseqs_formatted = MMSEQS_SEARCH_CANTHYD.out.mmseqs_search_formatted_out - formattedOutputChannels = formattedOutputChannels.mix(ch_canthyd_mmseqs_formatted) + formattedOutputchannels = formattedOutputchannels.mix(ch_canthyd_mmseqs_formatted) //HMM ch_combined_proteins_locs = ch_called_proteins.join(ch_gene_locs) @@ -269,24 +266,24 @@ workflow DB_SEARCH { // MEROPS annotation if (use_merops) { ch_combined_query_locs_merops = ch_mmseqs_query.join(ch_gene_locs) - MMSEQS_SEARCH_MEROPS( ch_combined_query_locs_merops, DB_CHANNEL_SETUP.out.ch_merops_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, merops_name ) + MMSEQS_SEARCH_MEROPS( ch_combined_query_locs_merops, DB_channel_SETUP.out.ch_merops_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, merops_name ) ch_merops_unformatted = MMSEQS_SEARCH_MEROPS.out.mmseqs_search_formatted_out SQL_MEROPS(ch_merops_unformatted, merops_name, ch_sql_descriptions_db) ch_merops_formatted = SQL_MEROPS.out.sql_formatted_hits - formattedOutputChannels = formattedOutputChannels.mix(ch_merops_formatted) + formattedOutputchannels = formattedOutputchannels.mix(ch_merops_formatted) } // Uniref annotation if (use_uniref) { ch_combined_query_locs_uniref = ch_mmseqs_query.join(ch_gene_locs) - MMSEQS_SEARCH_UNIREF( ch_combined_query_locs_uniref, DB_CHANNEL_SETUP.out.ch_uniref_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, uniref_name ) + MMSEQS_SEARCH_UNIREF( ch_combined_query_locs_uniref, DB_channel_SETUP.out.ch_uniref_db, params.bit_score_threshold, params.rbh_bit_score_threshold, default_sheet, uniref_name ) ch_uniref_unformatted = MMSEQS_SEARCH_UNIREF.out.mmseqs_search_formatted_out SQL_UNIREF(ch_uniref_unformatted, uniref_name, ch_sql_descriptions_db) ch_uniref_formatted = SQL_UNIREF.out.sql_formatted_hits - formattedOutputChannels = formattedOutputChannels.mix(ch_uniref_formatted) + formattedOutputchannels = formattedOutputchannels.mix(ch_uniref_formatted) } // Metals annotation if (use_metals) { @@ -319,16 +316,16 @@ workflow DB_SEARCH { // Viral annotation if (params.use_viral) { ch_combined_query_locs_viral = ch_mmseqs_query.join(ch_gene_locs) - MMSEQS_SEARCH_VIRAL( ch_combined_query_locs_viral, DB_CHANNEL_SETUP.out.ch_viral_db, params.bit_score_threshold, params.rbh_bit_score_threshold,default_sheet, viral_name ) + MMSEQS_SEARCH_VIRAL( ch_combined_query_locs_viral, DB_channel_SETUP.out.ch_viral_db, params.bit_score_threshold, params.rbh_bit_score_threshold,default_sheet, viral_name ) ch_viral_unformatted = MMSEQS_SEARCH_VIRAL.out.mmseqs_search_formatted_out SQL_VIRAL(ch_viral_unformatted, viral_name, ch_sql_descriptions_db) ch_viral_formatted = SQL_VIRAL.out.sql_formatted_hits - formattedOutputChannels = formattedOutputChannels.mix(ch_viral_formatted) + formattedOutputchannels = formattedOutputchannels.mix(ch_viral_formatted) } - fastas = formattedOutputChannels.map { it[1] }.collect() - genes = ch_called_proteins.map { it[1] }.collect() + fastas = formattedOutputchannels.map { it -> it[1] }.collect() + genes = ch_called_proteins.map { it -> it[1] }.collect() COMBINE_ANNOTATIONS( fastas, genes ) ch_combined_annotations = COMBINE_ANNOTATIONS.out.combined_annotations_out @@ -339,7 +336,7 @@ workflow DB_SEARCH { } -workflow DB_CHANNEL_SETUP { +workflow DB_channel_SETUP { take: use_kegg use_kofam diff --git a/subworkflows/local/merge.nf b/subworkflows/local/merge.nf index 8b4f7ece..a14fa940 100644 --- a/subworkflows/local/merge.nf +++ b/subworkflows/local/merge.nf @@ -31,10 +31,10 @@ workflow MERGE { } // Create a channel with the paths to the .tsv files - Channel - .from(tsv_files.collect { annotations_dir.toString() + '/' + it }) + channel + .from(tsv_files.collect { it -> annotations_dir.toString() + '/' + it }) .set { ch_merge_annotations } - Channel.empty() + channel.empty() .mix( ch_merge_annotations ) .collect() .set { ch_merge_annotations_collected } diff --git a/subworkflows/local/qc.nf b/subworkflows/local/qc.nf index 298c4fff..fe7a5bf8 100644 --- a/subworkflows/local/qc.nf +++ b/subworkflows/local/qc.nf @@ -25,39 +25,37 @@ workflow QC { // Add Bin Quality to annotations - if( params.bin_quality ){ + if ( params.bin_quality ) { ch_bin_quality = file(params.bin_quality) ADD_BIN_QUALITY( ch_combined_annotations, ch_bin_quality ) ch_updated_annots = ADD_BIN_QUALITY.out.annots_bin_quality_out } - else{ + else { ch_updated_annots = ch_combined_annotations } // Add Taxonomy to annotations - if( params.taxa ){ + if ( params.taxa ) { ch_taxa = file(params.taxa) ADD_TAXA( ch_updated_annots, ch_taxa ) ch_updated_taxa_annots = ADD_TAXA.out.annots_taxa_out } - else{ + else { ch_updated_taxa_annots = ch_combined_annotations } ch_final_annots = ch_updated_taxa_annots - if( params.generate_gff || params.generate_gbk ){ + if ( params.generate_gff || params.generate_gbk ) { if (!call) { - ch_called_genes = Channel + ch_called_genes = channel .fromPath(file(params.input_genes) / params.genes_fna_fmt, checkIfExists: true) .ifEmpty { exit 1, "If you specify --generate_gff or --generate_gbk without --call, you must provide a fasta file of called genes using --input_genes and --genes_fna_fmt,. Cannot find any called gene fasta files matching: ${params.input_genes} and ${params.genes_fna_fmt}\nNB: Path needs to follow pattern: path/to/directory/" } - .map { - input_fastaName = it.getBaseName() - tuple(input_fastaName, it) - } + .map { it -> [ it.getBaseName(), it ] } + // Collect all individual fasta to pass to quast - Channel.empty() + channel.empty() .mix( ch_called_genes ) .collect() .set { ch_collected_fna } diff --git a/tests/data/owc/summarize/metabolism_summary.xlsx b/tests/data/owc/summarize/metabolism_summary.xlsx deleted file mode 100644 index 4aaa878e..00000000 Binary files a/tests/data/owc/summarize/metabolism_summary.xlsx and /dev/null differ diff --git a/tests/data/owc/summarize/summarized_genomes.tsv b/tests/data/owc/summarize/summarized_genomes.tsv deleted file mode 100644 index 45494e78..00000000 --- a/tests/data/owc/summarize/summarized_genomes.tsv +++ /dev/null @@ -1,3685 +0,0 @@ -gene_id gene_description pathway topic_ecosystem category subcategory OWC_0000 OWC_0001 -K01647 citrate synthase [EC:2.3.3.1] [RN:R00351] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K05942 citrate (Re)-synthase [EC:2.3.3.3] [RN:R00351] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01681 aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900 R01324] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01682 aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900 R01324] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00031 isocitrate dehydrogenase [EC:1.1.1.42 1.1.1.41] [RN:R01899 R00268 R00267 R00709] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00030 isocitrate dehydrogenase [EC:1.1.1.42 1.1.1.41] [RN:R01899 R00268 R00267 R00709] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00164 2-oxoglutarate dehydrogenase complex [EC:1.2.4.2 2.3.1.61 1.8.1.4] [RN:R00621 R03316 R02570 R07618] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00658 2-oxoglutarate dehydrogenase complex [EC:1.2.4.2 2.3.1.61 1.8.1.4] [RN:R00621 R03316 R02570 R07618] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00382 2-oxoglutarate dehydrogenase complex [EC:1.2.4.2 2.3.1.61 1.8.1.4] [RN:R00621 R03316 R02570 R07618] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00174 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] [RN:R01197] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00175 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] [RN:R01197] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00177 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] [RN:R01197] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00176 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] [RN:R01197] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01902 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01903 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01899 succinyl-CoA synthetase [EC:6.2.1.4 6.2.1.5] [RN:R00405 R00432 R00727] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01900 succinyl-CoA synthetase [EC:6.2.1.4 6.2.1.5] [RN:R00405 R00432 R00727] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K18118 succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18] [RN:R10343] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00234 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00235 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00236 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00237 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00239 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00240 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00241 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00242 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K18859 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K18860 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00244 fumarate reductase [EC:1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00245 fumarate reductase [EC:1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00246 fumarate reductase [EC:1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00247 fumarate reductase [EC:1.3.5.4] [RN:R02164] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01676 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01679 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01677 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01678 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00026 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00025 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00024 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K00116 malate dehydrogenase (quinone) [EC:1.1.5.4] [RN:R00361] Citrate cycle (TCA cycle, Krebs cycle) carbon utilization central carbon TCA 0 0 -K01647 citrate synthase [EC:2.3.3.1] [RN:R00351] Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate carbon utilization central carbon TCA 0 0 -K05942 citrate (Re)-synthase [EC:2.3.3.3] [RN:R00351] Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate carbon utilization central carbon TCA 0 0 -K01681 aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900 R01324] Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate carbon utilization central carbon TCA 0 0 -K01682 aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900 R01324] Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate carbon utilization central carbon TCA 0 0 -K00031 isocitrate dehydrogenase [EC:1.1.1.42 1.1.1.41] [RN:R01899 R00268 R00267 R00709] Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate carbon utilization central carbon TCA 0 0 -K00030 isocitrate dehydrogenase [EC:1.1.1.42 1.1.1.41] [RN:R01899 R00268 R00267 R00709] Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate carbon utilization central carbon TCA 0 0 -K00164 2-oxoglutarate dehydrogenase [EC:1.2.4.2 2.3.1.61 1.8.1.4] [RN:R00621 R03316 R02570 R07618] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00658 2-oxoglutarate dehydrogenase [EC:1.2.4.2 2.3.1.61 1.8.1.4] [RN:R00621 R03316 R02570 R07618] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00382 2-oxoglutarate dehydrogenase [EC:1.2.4.2 2.3.1.61 1.8.1.4] [RN:R00621 R03316 R02570 R07618] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00174 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] [RN:R01197] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00175 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] [RN:R01197] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00177 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] [RN:R01197] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00176 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] [RN:R01197] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K01902 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K01903 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K01899 succinyl-CoA synthetase [EC:6.2.1.4 6.2.1.5] [RN:R00405 R00432 R00727] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K01900 succinyl-CoA synthetase [EC:6.2.1.4 6.2.1.5] [RN:R00405 R00432 R00727] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K18118 succinyl-CoA:acetate CoA-transferase [EC:2.8.3.18] [RN:R10343] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00234 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00235 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00236 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00237 succinate dehydrogenase [EC:1.3.5.1] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00239 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00240 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00241 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00242 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K18859 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K18860 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00244 fumarate reductase [EC:1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00245 fumarate reductase [EC:1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00246 fumarate reductase [EC:1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00247 fumarate reductase [EC:1.3.5.4] [RN:R02164] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K01676 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K01679 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K01677 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K01678 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00026 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00025 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00024 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00116 malate dehydrogenase (quinone) [EC:1.1.5.4] [RN:R00361] Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate carbon utilization central carbon TCA 0 0 -K00169 pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K00170 pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K00171 pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K00172 pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K01959 pyruvate carboxylase [EC:6.4.1.1] [RN:R00344] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K01960 pyruvate carboxylase [EC:6.4.1.1] [RN:R00344] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K00024 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K01677 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K01678 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K18209 fumarate reductase (CoM/CoB) [EC:1.3.4.1] [RN:R10660] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K18210 fumarate reductase (CoM/CoB) [EC:1.3.4.1] [RN:R10660] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K01902 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K01903 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K00174 2-oxoglutarate ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K00175 2-oxoglutarate ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K00176 2-oxoglutarate ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K00177 2-oxoglutarate ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197] Incomplete reductive citrate cycle, acetyl-CoA => oxoglutarate carbon utilization central carbon TCA 0 0 -K00027 malate dehydrogenase (oxaloacetate-decarboxylating) TCA /Reductive TCA carbon utilization central carbon TCA 0 0 -K13937 hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31] [RN:R02736 R02035] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K00036 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363 1.1.1.388] [RN:R02736 R10907] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K19243 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363 1.1.1.388] [RN:R02736 R10907] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K01057 6-phosphogluconolactonase [EC:3.1.1.31] [RN:R02035] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K07404 6-phosphogluconolactonase [EC:3.1.1.31] [RN:R02035] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K00033 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343] [RN:R01528 R10221] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K01783 ribulose-phosphate 3-epimerase [EC:5.1.3.1] [RN:R01529] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K01807 ribose 5-phosphate isomerase [EC:5.3.1.6] [RN:R01056] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K01808 ribose 5-phosphate isomerase [EC:5.3.1.6] [RN:R01056] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K00615 transketolase [EC:2.2.1.1] [RN:R01641] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K00616 transaldolase [EC:2.2.1.2] [RN:R01827] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K01810 glucose-6-phosphate isomerase [EC:5.3.1.9] [RN:R02740 R02739] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K06859 glucose-6-phosphate isomerase [EC:5.3.1.9] [RN:R02740 R02739] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K13810 glucose-6-phosphate isomerase [EC:5.3.1.9] [RN:R02740 R02739] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K15916 glucose-6-phosphate isomerase [EC:5.3.1.9] [RN:R02740 R02739] Pentose phosphate pathway (Pentose phosphate cycle) carbon utilization central carbon pentose pathway 0 0 -K00948 ribose-phosphate pyrophosphokinase [EC:2.7.6.1] [RN:R01049] PRPP biosynthesis, ribose 5P => PRPP carbon utilization central carbon pentose pathway 0 0 -K13937 hexose-6-phosphate dehydrogenase [EC:1.1.1.47 3.1.1.31] [RN:R02736 R02035] Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P carbon utilization central carbon pentose pathway 0 0 -K00036 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363 1.1.1.388] [RN:R02736 R10907] Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P carbon utilization central carbon pentose pathway 0 0 -K19243 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363 1.1.1.388] [RN:R02736 R10907] Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P carbon utilization central carbon pentose pathway 0 0 -K01057 6-phosphogluconolactonase [EC:3.1.1.31] [RN:R02035] Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P carbon utilization central carbon pentose pathway 0 0 -K07404 6-phosphogluconolactonase [EC:3.1.1.31] [RN:R02035] Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P carbon utilization central carbon pentose pathway 0 0 -K00033 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343] [RN:R01528 R10221] Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P carbon utilization central carbon pentose pathway 0 0 -K00615 transketolase [EC:2.2.1.1] [RN:R01830 R01641] Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K00616 transaldolase [EC:2.2.1.2] [RN:R01827] Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K13810 transaldolase [EC:2.2.1.2] [RN:R01827] Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K01783 ribulose-phosphate 3-epimerase [EC:5.1.3.1] [RN:R01529] Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K01807 ribose 5-phosphate isomerase [EC:5.3.1.6] [RN:R01056] Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K01808 ribose 5-phosphate isomerase [EC:5.3.1.6] [RN:R01056] Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K08094 6-phospho-3-hexuloisomerase [EC:5.3.1.27] [RN:R09780] Pentose phosphate pathway, archaea, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K08093 3-hexulose-6-phosphate synthase [EC:4.1.2.43] [RN:R05338] Pentose phosphate pathway, archaea, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K13812 3-hexulose-6-phosphate synthase [EC:4.1.2.43] [RN:R05338] Pentose phosphate pathway, archaea, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K13831 6-phospho-3-hexuloisomerase [EC:5.3.1.27] [RN:R09780] Pentose phosphate pathway, archaea, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K01807 ribose 5-phosphate isomerase A [EC:5.3.1.6] [RN:R01056] Pentose phosphate pathway, archaea, fructose 6P => ribose 5P carbon utilization central carbon pentose pathway 0 0 -K01053 gluconolactonase Pentose phosphate pathway carbon utilization central carbon pentose pathway 0 0 -K00844 hexokinase/glucokinase [EC:2.7.1.1 2.7.1.2] [RN:R01786] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K12407 hexokinase/glucokinase [EC:2.7.1.1 2.7.1.2] [RN:R01786] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K00845 hexokinase/glucokinase [EC:2.7.1.1 2.7.1.2] [RN:R01786] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K00886 polyphosphate glucokinase [EC:2.7.1.63] [RN:R02189] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K08074 K00918 ADP-dependent glucokinase [EC:2.7.1.147] [RN:R09085] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K00918 ADP-dependent phosphofructokinase [EC:2.7.1.146] [RN:R09084] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K01810 glucose-6-phosphate isomerase [EC:5.3.1.9] [RN:R02740] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K06859 glucose-6-phosphate isomerase [EC:5.3.1.9] [RN:R02740] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K13810 glucose-6-phosphate isomerase [EC:5.3.1.9] [RN:R02740] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K15916 glucose-6-phosphate isomerase [EC:5.3.1.9] [RN:R02740] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K00850 6-phosphofructokinase [EC:2.7.1.11] [RN:R04779] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K16370 6-phosphofructokinase [EC:2.7.1.11] [RN:R04779] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K01623 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01070] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K01624 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01070] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K11645 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01070] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K16305 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01070] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K16306 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01070] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K01803 triosephosphate isomerase [EC:5.3.1.1] [RN:R01015] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K00134 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12 1.2.1.59] [RN:R01061 R01063] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K00150 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12 1.2.1.59] [RN:R01061 R01063] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K00927 phosphoglycerate kinase [EC:2.7.2.3] [RN:R01512] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K11389 glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) [EC:1.2.7.6] [RN:R07159] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K01834 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K15633 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K15634 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K15635 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K01689 enolase [EC:4.2.1.11] [RN:R00658] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K00873 pyruvate kinase [EC:2.7.1.40] [RN:R00200] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K12406 pyruvate kinase [EC:2.7.1.40] [RN:R00200] Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate carbon utilization central carbon glycolysis 0 0 -K01803 triosephosphate isomerase [EC:5.3.1.1] [RN:R01015] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K00134 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12 1.2.1.59] [RN:R01061 R01063] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K00150 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12 1.2.1.59] [RN:R01061 R01063] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K00927 phosphoglycerate kinase [EC:2.7.2.3] [RN:R01512] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K11389 glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) [EC:1.2.7.6] [RN:R07159] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K01834 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K15633 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K15634 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K15635 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K01689 enolase [EC:4.2.1.11] [RN:R00658] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K00873 pyruvate kinase [EC:2.7.1.40] [RN:R00200] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K12406 pyruvate kinase [EC:2.7.1.40] [RN:R00200] Glycolysis, core module involving three-carbon compounds carbon utilization central carbon glycolysis 0 0 -K01596 phosphoenolpyruvate carboxykinase [EC:4.1.1.32 4.1.1.49] [RN:R00431 R00726 R00341] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K01610 phosphoenolpyruvate carboxykinase [EC:4.1.1.32 4.1.1.49] [RN:R00431 R00726 R00341] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K01689 enolase [EC:4.2.1.11] [RN:R00658] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K01834 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K15633 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K15634 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K15635 phosphoglycerate mutase [EC:5.4.2.11 5.4.2.12] [RN:R01518] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K00927 phosphoglycerate kinase [EC:2.7.2.3] [RN:R01512] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K00134 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12 1.2.1.59] [RN:R01061 R01063] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K00150 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12 1.2.1.59] [RN:R01061 R01063] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K01803 triosephosphate isomerase (TIM) [EC:5.3.1.1] [RN:R01015] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K01623 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01070] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K01624 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01070] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K11645 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01070] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K03841 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R04780] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K02446 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R04780] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K11532 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R04780] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K01086 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R04780] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K04041 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R04780] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K01622 fructose 1,6-bisphosphate aldolase/phosphatase [EC:4.1.2.13 3.1.3.11] [RN:R01070 R04780] Gluconeogenesis, oxaloacetate => fructose-6P carbon utilization central carbon glycolysis 0 0 -K00036 glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363] [RN:R02736 R10907] Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate carbon utilization central carbon glycolysis 0 0 -K01057 6-phosphogluconolactonase [EC:3.1.1.31] [RN:R02035] Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate carbon utilization central carbon glycolysis 0 0 -K07404 6-phosphogluconolactonase [EC:3.1.1.31] [RN:R02035] Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate carbon utilization central carbon glycolysis 0 0 -K01690 phosphogluconate dehydratase [EC:4.2.1.12] [RN:R02036] Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate carbon utilization central carbon glycolysis 0 0 -K01625 2-dehydro-3-deoxyphosphogluconate aldolase [EC:4.1.2.14] [RN:R05605] Entner-Doudoroff pathway, glucose-6P => glyceraldehyde-3P + pyruvate carbon utilization central carbon glycolysis 0 0 -K01647 citrate synthase [EC:2.3.3.1] [RN:R00351] Glyoxylate cycle carbon utilization central carbon glycolysis 0 0 -K01681 aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900] Glyoxylate cycle carbon utilization central carbon glycolysis 0 0 -K01682 aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900] Glyoxylate cycle carbon utilization central carbon glycolysis 0 0 -K01637 isocitrate lyase [EC:4.1.3.1] [RN:R00479] Glyoxylate cycle carbon utilization central carbon glycolysis 0 0 -K01638 malate synthase [EC:2.3.3.9] [RN:R00472] Glyoxylate cycle carbon utilization central carbon glycolysis 0 0 -K19282 bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30] [RN:R00473 R10612] Glyoxylate cycle carbon utilization central carbon glycolysis 0 0 -K00026 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Glyoxylate cycle carbon utilization central carbon glycolysis 0 0 -K00025 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Glyoxylate cycle carbon utilization central carbon glycolysis 0 0 -K00024 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Glyoxylate cycle carbon utilization central carbon glycolysis 0 0 -K05308 gluconate dehydratase [EC:4.2.1.140] [RN:R01538] Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K00874 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] [RN:R01541] Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K01625 2-dehydro-3-deoxyphosphogluconate aldolase [EC:4.1.2.14] [RN:R05605] Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K00134 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12] [RN:R01061] Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K00927 phosphoglycerate kinase [EC:2.7.2.3] [RN:R01512] Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K00131 glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] [RN:R01058] Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K18978 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] [EC:1.2.1.90] [RN:R01058 R10860] Semi-phosphorylative Entner-Doudoroff pathway, gluconate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K05308 gluconate/galactonate dehydratase [EC:4.2.1.140] [RN:R01538 R03033] Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate carbon utilization central carbon glycolysis 0 0 -K11395 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase [EC:4.1.2.55] [RN:R08570 R10616] Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate carbon utilization central carbon glycolysis 0 0 -K18127 2-dehydro-3-deoxy-D-gluconate aldolase [EC:4.1.2.51] [RN:R08570 R10616] Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate carbon utilization central carbon glycolysis 0 0 -K18020 glyceraldehyde dehydrogenase large subunit [EC:1.2.99.8] [RN:R10324] Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate carbon utilization central carbon glycolysis 0 0 -K18021 glyceraldehyde dehydrogenase large subunit [EC:1.2.99.8] [RN:R10324] Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate carbon utilization central carbon glycolysis 0 0 -K18022 glyceraldehyde dehydrogenase large subunit [EC:1.2.99.8] [RN:R10324] Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate carbon utilization central carbon glycolysis 0 0 -K18128 glyceraldehyde dehydrogenase [EC:1.2.1.89] [RN:R10615] Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate carbon utilization central carbon glycolysis 0 0 -K03738 aldehyde:ferredoxin oxidoreductase [EC:1.2.7.5] [RN:R08571] Non-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate carbon utilization central carbon glycolysis 0 0 -K01684 galactonate dehydratase [EC:4.2.1.6] [RN:R03033] D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K00883 2-dehydro-3-deoxygalactonokinase [EC:2.7.1.58] [RN:R03387] D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K01631 2-dehydro-3-deoxyphosphogalactonate aldolase [EC:4.1.2.21] [RN:R01064] D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K00134 glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12] [RN:R01061] D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K00927 phosphoglycerate kinase [EC:2.7.2.3] [RN:R01512] D-galactonate degradation, De Ley-Doudoroff pathway, D-galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K01812 glucuronate isomerase [EC:5.3.1.12] [RN:R01983] D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P carbon utilization central carbon glycolysis 0 0 -K00041 tagaturonate reductase [EC:1.1.1.58] [RN:R02555] D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P carbon utilization central carbon glycolysis 0 0 -K01685 altronate hydrolase [EC:4.2.1.7] [RN:R01540] D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P carbon utilization central carbon glycolysis 0 0 -K16849 altronate hydrolase [EC:4.2.1.7] [RN:R01540] D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P carbon utilization central carbon glycolysis 0 0 -K16850 altronate hydrolase [EC:4.2.1.7] [RN:R01540] D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P carbon utilization central carbon glycolysis 0 0 -K00874 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] [RN:R01541] D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P carbon utilization central carbon glycolysis 0 0 -K01625 2-dehydro-3-deoxy-phosphogluconate aldolase [EC:4.1.2.14] [RN:R05605] D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P carbon utilization central carbon glycolysis 0 0 -K17463 2-dehydro-3-deoxy-phosphogluconate aldolase [EC:4.1.2.14] [RN:R05605] D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P carbon utilization central carbon glycolysis 0 0 -K01785 aldose 1-epimerase [EC:5.1.3.3] [RN:R10619] Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P carbon utilization central carbon glycolysis 0 0 -K00849 galactokinase [EC:2.7.1.6] [RN:R01092] Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P carbon utilization central carbon glycolysis 0 0 -K00965 UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12] [RN:R00955] Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P carbon utilization central carbon glycolysis 0 0 -K01784 UDP-glucose 4-epimerase [EC:5.1.3.2] [RN:R00291] Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P carbon utilization central carbon glycolysis 0 0 -K05308 gluconate dehydratase [EC:4.2.1.140] [RN:R01538 R03033] Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K18126 2-dehydro-3-deoxygluconokinase [EC:2.7.1.178] [RN:R01541 R03387] Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K11395 2-dehydro-3-deoxyphosphogluconate aldolase [EC:4.1.2.55] [RN:R05605 R01064] Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K00131 glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] [RN:R01058] Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K18978 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] [EC:1.2.1.90] [RN:R01058 R10860] Semi-phosphorylative Entner-Doudoroff pathway, gluconate/galactonate => glycerate-3P carbon utilization central carbon glycolysis 0 0 -K00163 pyruvate dehydrogenase complex [EC:1.2.4.1 2.3.1.12 1.8.1.4] [RN:R00209] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K00161 pyruvate dehydrogenase complex [EC:1.2.4.1 2.3.1.12 1.8.1.4] [RN:R00209] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K00162 pyruvate dehydrogenase complex [EC:1.2.4.1 2.3.1.12 1.8.1.4] [RN:R00209] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K00627 pyruvate dehydrogenase complex [EC:1.2.4.1 2.3.1.12 1.8.1.4] [RN:R00209] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K00382 pyruvate dehydrogenase complex [EC:1.2.4.1 2.3.1.12 1.8.1.4] [RN:R00209] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K13997 pyruvate dehydrogenase complex [EC:1.2.4.1 2.3.1.12 1.8.1.4] [RN:R00209] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K00169 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K00170 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K00171 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K00172 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K03737 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Pyruvate oxidation, pyruvate => acetyl-CoA carbon utilization pyruvate metabolism 0 0 -K00625 phosphate acetyltransferase [EC:2.3.1.8] [RN:R00230] Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate carbon utilization pyruvate metabolism 0 0 -K13788 phosphate acetyltransferase [EC:2.3.1.8] [RN:R00230] Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate carbon utilization pyruvate metabolism 0 0 -K15024 phosphate acetyltransferase [EC:2.3.1.8] [RN:R00230] Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate carbon utilization pyruvate metabolism 0 0 -K00925 acetate kinase [EC:2.7.2.1] [RN:R00315] Phosphate acetyltransferase-acetate kinase pathway, acetyl-CoA => acetate carbon utilization pyruvate metabolism 0 0 -K01965 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K01966 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K11263 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K18472 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K19312 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K22568 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K01964 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K15036 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K15037 propionyl-CoA carboxylase [EC:6.4.1.3] [RN:R01859] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K05606 methylmalonyl-CoA/ethylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K01847 methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K01848 methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K01849 methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833] Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA carbon utilization pyruvate metabolism 0 0 -K00132 acetaldehyde dehydrogenase (acetylating) fermentation- carbon utilization pyruvate metabolism 0 0 -K13954 alcohol dehydrogenase fermentation- carbon utilization pyruvate metabolism 0 0 -K00001 alcohol dehydrogenase fermentation- carbon utilization pyruvate metabolism 0 0 -K00016 L-lactate dehydrogenase fermentation- carbon utilization pyruvate metabolism 0 0 -K03778 D-lactate dehydrogenase fermentation- carbon utilization pyruvate metabolism 0 0 -K00656 formate acetyltransferase (pyruvate-formate lyase ) pyruvate metabolism carbon utilization pyruvate metabolism 0 0 -K04069 pyruvate formate lyase activating enzyme pyruvate metabolism carbon utilization pyruvate metabolism 0 0 -K04070 putative pyruvate formate lyase activating enzyme pyruvate metabolism carbon utilization pyruvate metabolism 0 0 -K01512 acylphosphatase pyruvate metabolism carbon utilization pyruvate metabolism 0 0 -K00074 3-hydroxybutyryl-CoA dehydrogenase pyruvate metabolism carbon utilization pyruvate metabolism 0 0 -K07540 benzylsuccinate synthase [EC:4.1.99.11] [RN:R05598] Toluene degradation, anaerobic, toluene => benzoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07543 benzylsuccinate CoA-transferase subunit [EC:2.8.3.15] [RN:R05588] Toluene degradation, anaerobic, toluene => benzoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07544 benzylsuccinate CoA-transferase subunit [EC:2.8.3.15] [RN:R05588] Toluene degradation, anaerobic, toluene => benzoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07545 bbsG; (R)-benzylsuccinyl-CoA dehydro genase [EC:1.3.8.3] [RN:R05584] Toluene degradation, anaerobic, toluene => benzoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07546 bbsH; E-phenylitaconyl-CoA hydratase [EC:4.2.1.-] [RN:R05599] Toluene degradation, anaerobic, toluene => benzoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07547 2-[hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase [EC:1.1.1.35] [RN:R05575] Toluene degradation, anaerobic, toluene => benzoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07548 2-[hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase [EC:1.1.1.35] [RN:R05575] Toluene degradation, anaerobic, toluene => benzoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07549 benzoylsuccinyl-CoA thiolase [EC:2.3.1.-] [RN:R05587] Toluene degradation, anaerobic, toluene => benzoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07550 benzoylsuccinyl-CoA thiolase [EC:2.3.1.-] [RN:R05587] Toluene degradation, anaerobic, toluene => benzoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K05549 benzoate/toluate 1,2-dioxygenase [EC:1.14.12.10 1.14.12.-] [RN:R05621 R05290 R05428 R05665] Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol carbon utilization hydrocarbon degradation 0 0 -K05550 benzoate/toluate 1,2-dioxygenase [EC:1.14.12.10 1.14.12.-] [RN:R05621 R05290 R05428 R05665] Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol carbon utilization hydrocarbon degradation 0 0 -K05784 benzoate/toluate 1,2-dioxygenase [EC:1.14.12.10 1.14.12.-] [RN:R05621 R05290 R05428 R05665] Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol carbon utilization hydrocarbon degradation 0 0 -K05783 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase [EC:1.3.1.25] [RN:R00813 R05292 R05314 R05309] Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol carbon utilization hydrocarbon degradation 0 0 -K18106 D-galacturonate reductase [EC:1.1.1.-] [RN:R07676 R10565] D-Galacturonate degradation (fungi), D-galacturonate => glycerol carbon utilization hydrocarbon degradation 0 0 -K19634 D-galacturonate reductase [EC:1.1.1.365] [RN:R07676] D-Galacturonate degradation (fungi), D-galacturonate => glycerol carbon utilization hydrocarbon degradation 0 0 -K18102 L-galactonate dehydratase [EC:4.2.1.146] [RN:R10532] D-Galacturonate degradation (fungi), D-galacturonate => glycerol carbon utilization hydrocarbon degradation 0 0 -K18103 L-threo-3-deoxy-hexylosonate aldolase [EC:4.1.2.54] [RN:R10550] D-Galacturonate degradation (fungi), D-galacturonate => glycerol carbon utilization hydrocarbon degradation 0 0 -K18107 L-glyceraldehyde reductase [EC:1.1.1.372] [RN:R10563] D-Galacturonate degradation (fungi), D-galacturonate => glycerol carbon utilization hydrocarbon degradation 0 0 -K00455 3,4-dihydroxyphenylacetate 2,3-dioxygenase [EC:1.13.11.15] [RN:R03303] Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate carbon utilization hydrocarbon degradation 0 0 -K00151 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC:1.2.1.60] [RN:R04418] Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate carbon utilization hydrocarbon degradation 0 0 -K10219 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312] [RN:R04418] Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate carbon utilization hydrocarbon degradation 0 0 -K01826 5-carboxymethyl-2-hydroxymuconate isomerase [EC:5.3.3.10][RN:R04379] Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate carbon utilization hydrocarbon degradation 0 0 -K05921 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [EC:4.1.1.68 5.3.3.-] [RN:R04380 R04134] Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate carbon utilization hydrocarbon degradation 0 0 -K14579 nahA; naphthalene 1,2-dioxygenase [EC:1.14.12.12] [RN:R02968] Naphthalene degradation, naphthalene => salicylate carbon utilization hydrocarbon degradation 0 0 -K14580 nahA; naphthalene 1,2-dioxygenase [EC:1.14.12.12] [RN:R02968] Naphthalene degradation, naphthalene => salicylate carbon utilization hydrocarbon degradation 0 0 -K14578 nahA; naphthalene 1,2-dioxygenase [EC:1.14.12.12] [RN:R02968] Naphthalene degradation, naphthalene => salicylate carbon utilization hydrocarbon degradation 0 0 -K14581 nahA; naphthalene 1,2-dioxygenase [EC:1.14.12.12] [RN:R02968] Naphthalene degradation, naphthalene => salicylate carbon utilization hydrocarbon degradation 0 0 -K14582 nahB; cis-1,2-dihydro-1,2-dihydroxynaphthalene/dibenzothiophene dihydrodiol dehydrogenase [EC:1.3.1.29] [RN:R04115] Naphthalene degradation, naphthalene => salicylate carbon utilization hydrocarbon degradation 0 0 -K14583 1,2-dihydroxynaphthalene dioxygenase [EC:1.13.11.56] [RN:R04117] Naphthalene degradation, naphthalene => salicylate carbon utilization hydrocarbon degradation 0 0 -K14584 2-hydroxychromene-2-carboxylate isomerase [EC:5.99.1.4] [RN:R05137] Naphthalene degradation, naphthalene => salicylate carbon utilization hydrocarbon degradation 0 0 -K14585 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase [EC:4.1.2.45] [RN:R05136] Naphthalene degradation, naphthalene => salicylate carbon utilization hydrocarbon degradation 0 0 -K00152 salicylaldehyde dehydrogenase [EC:1.2.1.65] [RN:R02941] Naphthalene degradation, naphthalene => salicylate carbon utilization hydrocarbon degradation 0 0 -K15757 xylM; xylene monooxygenase [EC:1.14.13.-] [RN:R05288 R05442 R05443] Xylene degradation, xylene => methylbenzoate carbon utilization hydrocarbon degradation 0 0 -K15758 xylene monooxygenase electron transfer component [EC:1.18.1.3] Xylene degradation, xylene => methylbenzoate carbon utilization hydrocarbon degradation 0 0 -K00055 E1.1.1.90; aryl-alcohol dehydrogenase [EC:1.1.1.90] [RN:R05282 R05348 R05347] Xylene degradation, xylene => methylbenzoate carbon utilization hydrocarbon degradation 0 0 -K00141 xylC; benzaldehyde dehydrogenase (NAD) [EC:1.2.1.28] [RN:R05289 R05663 R05664] Xylene degradation, xylene => methylbenzoate carbon utilization hydrocarbon degradation 0 0 -K15760 toluene monooxygenase system [EC:1.14.13.-] [RN:R02550] Toluene degradation, toluene => benzoate carbon utilization hydrocarbon degradation 0 0 -K15761 toluene monooxygenase system [EC:1.14.13.-] [RN:R02550] Toluene degradation, toluene => benzoate carbon utilization hydrocarbon degradation 0 0 -K15762 toluene monooxygenase system [EC:1.14.13.-] [RN:R02550] Toluene degradation, toluene => benzoate carbon utilization hydrocarbon degradation 0 0 -K15763 toluene monooxygenase system [EC:1.14.13.-] [RN:R02550] Toluene degradation, toluene => benzoate carbon utilization hydrocarbon degradation 0 0 -K15764 toluene monooxygenase system [EC:1.14.13.-] [RN:R02550] Toluene degradation, toluene => benzoate carbon utilization hydrocarbon degradation 0 0 -K15765 toluene monooxygenase system [EC:1.14.13.-] [RN:R02550] Toluene degradation, toluene => benzoate carbon utilization hydrocarbon degradation 0 0 -K00055 xylB; aryl-alcohol dehydrogenase [EC:1.1.1.90] [RN:R01763] Toluene degradation, toluene => benzoate carbon utilization hydrocarbon degradation 0 0 -K00141 xylC; benzaldehyde dehydrogenase (NAD) [EC:1.2.1.28] [RN:R01419] Toluene degradation, toluene => benzoate carbon utilization hydrocarbon degradation 0 0 -K10619 cmtA; p-cumate 2,3-dioxygenase [EC:1.14.12.25] [RN:R05247] Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate carbon utilization hydrocarbon degradation 0 0 -K16303 cmtA; p-cumate 2,3-dioxygenase [EC:1.14.12.25] [RN:R05247] Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate carbon utilization hydrocarbon degradation 0 0 -K16304 cmtA; p-cumate 2,3-dioxygenase [EC:1.14.12.25] [RN:R05247] Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate carbon utilization hydrocarbon degradation 0 0 -K18227 cmtA; p-cumate 2,3-dioxygenase [EC:1.14.12.25] [RN:R05247] Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate carbon utilization hydrocarbon degradation 0 0 -K10620 cmtB; 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase [EC:1.3.1.58] [RN:R05240] Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate carbon utilization hydrocarbon degradation 0 0 -K10621 cmtC; 2,3-dihydroxy-p-cumate-3,4-dioxygenase [EC:1.13.11.-] [RN:R05248] Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate carbon utilization hydrocarbon degradation 0 0 -K10622 cmtD; HCOMODA decarboxylase [EC:4.1.1.-] [RN:R05377] Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate carbon utilization hydrocarbon degradation 0 0 -K10623 cmtE; HOMODA hydrolase [EC:3.7.1.-] [RN: R05364] Cumate degradation, p-cumate => 2-oxopent-4-enoate + 2-methylpropanoate carbon utilization hydrocarbon degradation 0 0 -K04116 aliA; cyclohexanecarboxylate-CoA ligase [EC:6.2.1.-] [RN:R05620] Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K04117 aliB; cyclohexanecarboxyl-CoA dehydrogenase [EC:1.3.99.-] [RN:R05619] Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07534 badK; cyclohex-1-ene-1-carboxyl-CoA hydratase [EC:4.2.1.-] [RN:R05600] Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07535 badH; 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase [EC:1.1.1.-] [RN:R05582] Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07536 badI; 2-ketocyclohexanecarboxyl-CoA hydrolase [EC:3.1.2.-] [RN:R05592] Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K04112 benzoyl-CoA reductase [EC:1.3.7.8] [RN:R02451] Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K04113 benzoyl-CoA reductase [EC:1.3.7.8] [RN:R02451] Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K04114 benzoyl-CoA reductase [EC:1.3.7.8] [RN:R02451] Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K04115 benzoyl-CoA reductase [EC:1.3.7.8] [RN:R02451] Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K19515 benzoyl-CoA reductase [EC:1.3.-.-] [RN:R10961] Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K19516 benzoyl-CoA reductase [EC:1.3.-.-] [RN:R10961] Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07537 cyclohexa-1,5-dienecarbonyl-CoA hydratase [EC:4.2.1.100] [RN:R05597] Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07538 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase [EC:1.1.1.368] [RN:R05581] Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07539 6-oxo-cyclohex-1-ene-carbonyl-CoA hydrolase [EC:3.7.1.21] [RN:R05594] Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA carbon utilization hydrocarbon degradation 0 0 -K08689 biphenyl 2,3-dioxygenase [EC:1.14.12.18] [RN:R05263 R05264 R05261 R05262] Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate carbon utilization hydrocarbon degradation 0 0 -K15750 biphenyl 2,3-dioxygenase [EC:1.14.12.18] [RN:R05263 R05264 R05261 R05262] Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate carbon utilization hydrocarbon degradation 0 0 -K18087 biphenyl 2,3-dioxygenase [EC:1.14.12.18] [RN:R05263 R05264 R05261 R05262] Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate carbon utilization hydrocarbon degradation 0 0 -K18088 biphenyl 2,3-dioxygenase [EC:1.14.12.18] [RN:R05263 R05264 R05261 R05262] Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate carbon utilization hydrocarbon degradation 0 0 -K08690 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [EC:1.3.1.56] [RN:R05239 R05241] Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate carbon utilization hydrocarbon degradation 0 0 -K00462 biphenyl-2,3-diol 1,2-dioxygenase [EC:1.13.11.39] [RN:R03462 R05245] Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate carbon utilization hydrocarbon degradation 0 0 -K10222 2,6-dioxo-6-phenylhexa-3-enoate hydrolase [EC:3.7.1.8] [RN:R02606 R05359] Biphenyl degradation, biphenyl => 2-oxopent-4-enoate + benzoate carbon utilization hydrocarbon degradation 0 0 -K15751 carbazole 1,9a-dioxygenase [EC:1.14.12.22] [RN:R05414 R09512] Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate carbon utilization hydrocarbon degradation 0 0 -K15752 carbazole 1,9a-dioxygenase [EC:1.14.12.22] [RN:R05414 R09512] Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate carbon utilization hydrocarbon degradation 0 0 -K15753 carbazole 1,9a-dioxygenase [EC:1.14.12.22] [RN:R05414 R09512] Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate carbon utilization hydrocarbon degradation 0 0 -K15754 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase [EC:1.13.11.-] [RN:R05415] Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate carbon utilization hydrocarbon degradation 0 0 -K15755 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase [EC:1.13.11.-] [RN:R05415] Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate carbon utilization hydrocarbon degradation 0 0 -K15756 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2, 4-dienoate hydrolase [EC:3.7.1.13] [RN:R05365] Carbazole degradation, carbazole => 2-oxopent-4-enoate + anthranilate carbon utilization hydrocarbon degradation 0 0 -K05708 3-phenylpropionate/cinnamic acid dioxygenase [EC:1.14.12.19] [RN:R06783] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K05709 3-phenylpropionate/cinnamic acid dioxygenase [EC:1.14.12.19] [RN:R06783] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K05710 3-phenylpropionate/cinnamic acid dioxygenase [EC:1.14.12.19] [RN:R06783] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K00529 3-phenylpropionate/cinnamic acid dioxygenase [EC:1.14.12.19] [RN:R06783] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K05711 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [EC:1.3.1.87] [RN:R06785] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K05712 mhpA; 3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.127] [RN:R06787] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K05713 2,3-dihydroxyphenylpropionate 1,2-dioxygenase [EC:1.13.11.16] [RN:R06788] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K05714 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase [EC:3.7.1.14] [RN:R06789] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K02554 2-keto-4-pentenoate hydratase [EC:4.2.1.80] [RN:R02601] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K01666 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39] [RN:R00750] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K04073 acetaldehyde dehydrogenase [EC:1.2.1.10] [RN:R00228] Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA carbon utilization hydrocarbon degradation 0 0 -K03268 benzene/toluene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11] [RN:R03543 R03559] Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol carbon utilization hydrocarbon degradation 0 0 -K16268 benzene/toluene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11] [RN:R03543 R03559] Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol carbon utilization hydrocarbon degradation 0 0 -K18089 benzene/toluene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11] [RN:R03543 R03559] Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol carbon utilization hydrocarbon degradation 0 0 -K18090 benzene/toluene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11] [RN:R03543 R03559] Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol carbon utilization hydrocarbon degradation 0 0 -K16269 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase [EC:1.3.1.19] [RN:R00812 R04088] Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol carbon utilization hydrocarbon degradation 0 0 -K16249 dmpK; phenol hydroxylase P0 protein [RN:R10042 R10043] Benzene degradation, benzene => catechol carbon utilization hydrocarbon degradation 0 0 -K16243 dmpL; Phenol hydroxylase P1 protein [RN:R10042 R10043] Benzene degradation, benzene => catechol carbon utilization hydrocarbon degradation 0 0 -K16244 dmpM; phenol hydroxylase P2 protein [RN:R10042 R10043] Benzene degradation, benzene => catechol carbon utilization hydrocarbon degradation 0 0 -K16242 dmpN; phenol hydroxylase P3 protein [EC:1.14.13.-] [RN:R10042 R10043] Benzene degradation, benzene => catechol carbon utilization hydrocarbon degradation 0 0 -K16245 dmpO; phenol hydroxylase P4 protein [RN:R10042 R10043] Benzene degradation, benzene => catechol carbon utilization hydrocarbon degradation 0 0 -K16246 dmpP; phenol hydroxylase P5 protein [RN:R10042 R10043] Benzene degradation, benzene => catechol carbon utilization hydrocarbon degradation 0 0 -K18068 phthalate 4,5-dioxygenase [EC:1.14.12.7] [RN:R03630] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K18069 phthalate 4,5-dioxygenase [EC:1.14.12.7] [RN:R03630] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K18067 phthalate 4,5-cis-dihydrodiol dehydrogenase [EC:1.3.1.64] [RN:R05275] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K04102 4,5-dihydroxyphthalate decarboxylase [EC:4.1.1.55] [RN:R01635] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K18074 K18075,K18077 terephthalate 1,2-dioxygenase [EC:1.14.12.15] [RN:R05148] Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate carbon utilization hydrocarbon degradation 0 0 -K18075 tphA3 Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate carbon utilization hydrocarbon degradation 0 0 -K18077 tphA1 Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate carbon utilization hydrocarbon degradation 0 0 -K18076 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate dehydrogenase [EC:1.3.1.53] [RN:R01633] Terephthalate degradation, terephthalate => 3,4-dihydroxybenzoate carbon utilization hydrocarbon degradation 0 0 -K18251 phtA; phthalate 3,4-dioxygenase [EC:1.14.12.-] [RN:R09227] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K18252 phtA; phthalate 3,4-dioxygenase [EC:1.14.12.-] [RN:R09227] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K18253 phtA; phthalate 3,4-dioxygenase [EC:1.14.12.-] [RN:R09227] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K18254 phtA; phthalate 3,4-dioxygenase [EC:1.14.12.-] [RN:R09227] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K18255 phtB; phthalate 3,4-cis-dihydrodiol dehydrogenase [EC:1.3.1.-] [RN:R09228] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K18256 phtC; 3,4-dihydroxyphthalate decarboxylase [EC:4.1.1.69] [RN:R01634] Phthalate degradation, phthalate => protocatechuate carbon utilization hydrocarbon degradation 0 0 -K03381 catechol 1,2-dioxygenase [EC:1.13.11.1] [RN:R00817] Catechol ortho-cleavage, catechol => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K01856 muconate cycloisomerase [EC:5.5.1.1] [RN:R06989] Catechol ortho-cleavage, catechol => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K03464 muconolactone D-isomerase [EC:5.3.3.4] [RN:R06990] Catechol ortho-cleavage, catechol => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K01055 3-oxoadipate enol-lactonase [EC:3.1.1.24] [RN:R02991] Catechol ortho-cleavage, catechol => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K14727 oxoadipate enol-lactonase / 4-carboxymuconolactone decarboxylase [EC:3.1.1.24 4.1.1.44] Catechol ortho-cleavage, catechol => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K00446 catechol 2,3-dioxygenase [EC:1.13.11.2] [RN:R00816 R05295] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K07104 catechol 2,3-dioxygenase [EC:1.13.11.2] [RN:R00816 R05295] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K10217 2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.85] [RN:R02762 R05353] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K01821 4-oxalocrotonate tautomerase [EC:5.3.2.6] [RN:R03966 R05389] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K01617 4-oxalocrotonate decarboxylase [EC:4.1.1.77] [RN:R02602 R05374] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K10216 2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9] [RN:R02604 R05865] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K18364 2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase [EC:4.2.1.80 4.2.1.132] [RN:R02601 R05864] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K02554 2-keto-4-pentenoate hydratase [EC:4.2.1.80] [RN:R02601] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K18365 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43] [RN:R00750 R05298] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K01666 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39] [RN:R00750] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K18366 acetaldehyde/propanal dehydrogenase [EC:1.2.1.10 1.2.1.87] [RN:R00228 R09097] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K04073 acetaldehyde dehydrogenase [EC:1.2.1.10] [RN:R00228] Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K00448 pcaG; protocatechuate 3,4-dioxygenase, alpha subunit [EC:1.13.11.3] protocatechuate degradation, protocatechuate => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K00449 pcaH; protocatechuate 3,4-dioxygenase, beta subunit [EC:1.13.11.3] protocatechuate degradation, protocatechuate => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K01857 pcaB; 3-carboxy-cis,cis-muconate cycloisomerase [EC:5.5.1.2] protocatechuate degradation, protocatechuate => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K01607 pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44] protocatechuate degradation, protocatechuate => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K14727 pcaL; 3-oxoadipate enol-lactonase / 4-carboxymuconolactone decarboxylase [EC:3.1.1.24 4.1.1.44] protocatechuate degradation, protocatechuate => 3-oxoadipate carbon utilization hydrocarbon degradation 0 0 -K04100 ligaA; protocatechuate 4,5-dioxygenase, alpha chain [EC:1.13.11.8] protocatechuate degradation, protocatechuate => oxaloacteate + pyruvate carbon utilization hydrocarbon degradation 0 0 -K04101 ligB; protocatechuate 4,5-dioxygenase, beta chain [EC:1.13.11.8] protocatechuate degradation, protocatechuate => oxaloacteate + pyruvate carbon utilization hydrocarbon degradation 0 0 -K10219 ligC; 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312] protocatechuate degradation, protocatechuate => oxaloacteate + pyruvate carbon utilization hydrocarbon degradation 0 0 -K10221 ligI; 2-pyrone-4,6-dicarboxylate lactonase [EC:3.1.1.57] protocatechuate degradation, protocatechuate => oxaloacteate + pyruvate carbon utilization hydrocarbon degradation 0 0 -K16514 galD; 4-oxalomesaconate tautomerase [EC:5.3.2.8] protocatechuate degradation, protocatechuate => oxaloacteate + pyruvate carbon utilization hydrocarbon degradation 0 0 -K10220 ligJ; 4-oxalmesaconate hydratase [EC:4.2.1.83] protocatechuate degradation, protocatechuate => oxaloacteate + pyruvate carbon utilization hydrocarbon degradation 0 0 -K10218 ligK; 4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17] protocatechuate degradation, protocatechuate => oxaloacteate + pyruvate carbon utilization hydrocarbon degradation 0 0 -K10759 tannase [EC:3.1.1.20] hydrolyzable tannin degradation => gallate carbon utilization hydrocarbon degradation 0 0 -K04099 desB, galA; gallate dioxygenase [EC:1.13.11.57] aerobic gallate degradation carbon utilization hydrocarbon degradation 0 0 -K22958 lpdC; gallate decarboxylase subunit C [EC:4.1.1.59] anaerobic gallate degradation, gallate => 3-hydroxybutanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K22959 lpdB; gallate decarboxylase subunit B anaerobic gallate degradation, gallate => 3-hydroxybutanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K22960 lpdD; gallate decarboxylase subunit D anaerobic gallate degradation, gallate => 3-hydroxybutanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -1.97.1.2 pyrogallol transhydroxylase anaerobic gallate degradation, gallate => 3-hydroxybutanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -1.3.1.57 phloroglucinol reductase anaerobic gallate degradation, gallate => 3-hydroxybutanoyl-CoA carbon utilization hydrocarbon degradation 0 0 -K15064 desA; syringate O-demethylase [EC:2.1.1.-] lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K15066 ligM; vanillate/3-O-methylgallate O-demethylase [EC:2.1.1.341] lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K15065 desZ; 3-O-methylgallate 3,4-dioxygenase [EC:1.13.11.-] lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -k21802 vdh; vanillin dehydrogenase [EC:1.2.1.67] lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K03862 vanA; vanillate monooxygenase [EC:1.14.13.82] lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K03863 vanB; vanillate monooxygenase ferredoxin subunit lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K15060 ligX; 5,5'-dehydrodivanillate O-demethylase lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K15061 ligZ; OH-DDVA oxygenase lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K15062 ligY; OH-DDVA meta-cleavage compound hydrolase lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K15063 ligW; 5-carboxyvanillate decarboxylase lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K23526 gcoA; aromatic O-demethylase, cytochrome P450 subunit [EC:1.14.14.-] lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -K23527 gcoB; aromatic O-demethylase, reductase subunit [EC:1.6.2.-] lignin subunit degradation carbon utilization hydrocarbon degradation 0 0 -AA0 AA0 Auxiliary Activities carbon utilization CAZY 0 0 -AA10 AA10 (formerly CBM33) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); some proteins have been shown to act on chitin, others on cellulose; lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54); lytic cellulose monooxygenase (C4-dehydrogenating)(EC 1.14.99.56); lytic chitin monooxygenase (EC 1.14.99.53) Auxiliary Activities carbon utilization CAZY Crystalline Cellulose Backbone Cleavage, Crystalline Cellulose Backbone Cleavage, Chitin Oligo Cleavage 0 0 -AA11 AA11 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); cleavage of chitin chains with oxidation of C-1 has been demonstrated for a AA11 LPMO from Aspergillus oryzae; Auxiliary Activities carbon utilization CAZY Crystalline Cellulose Backbone Cleavage, Chitin Oligo Cleavage 0 0 -AA12 AA12 The pyrroloquinoline quinone-dependent oxidoreductase activity was demonstrated for the CC1G_09525 protein of Coprinopsis cinerea. Auxiliary Activities carbon utilization CAZY 0 0 -AA13 AA13 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); cleavage of starch with oxidation of C-1 at the site of cleavage has been demonstrated for the LPMO encoded by gene NCU08746 from Neurospora crassa; Auxiliary Activities carbon utilization CAZY Crystalline Cellulose Backbone Cleavage, Starch Backbone Cleavage 0 0 -AA14 AA14 proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); cleavage of xylan with oxidation of C-1 has been demonstrated for two AA14 LPMOs from Trametes coccinea (Pycnoporus coccineus); lytic xylan monooxygenase / xylan oxidase (glycosidic bond-cleaving) (EC 1.-.-.-) Auxiliary Activities carbon utilization CAZY 0 0 -AA15 AA15 lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54); lytic chitin monooxygenase (EC 1.14.99.53) Auxiliary Activities carbon utilization CAZY Crystalline Cellulose Backbone Cleavage, Chitin Oligo Cleavage 0 0 -AA16 AA16 Lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54) Auxiliary Activities carbon utilization CAZY Crystalline Cellulose Backbone Cleavage 0 0 -AA1 AA1 Laccase / p-diphenol:oxygen oxidoreductase / ferroxidase (EC 1.10.3.2); ; ferroxidase (EC 1.10.3.-); Laccase-like multicopper oxidase (EC 1.10.3.-) Auxiliary Activities carbon utilization CAZY Polyphenolics Cleavage 0 0 -AA2 AA2 manganese peroxidase (EC 1.11.1.13); versatile peroxidase (EC 1.11.1.16); lignin peroxidase (EC 1.11.1.14); peroxidase (EC 1.11.1.-) Auxiliary Activities carbon utilization CAZY Polyphenolics Cleavage 0 0 -AA3 AA3 cellobiose dehydrogenase (EC 1.1.99.18); glucose 1-oxidase (EC 1.1.3.4); aryl alcohol oxidase (EC 1.1.3.7); alcohol oxidase (EC 1.1.3.13); pyranose oxidase (EC 1.1.3.10) Auxiliary Activities carbon utilization CAZY 0 0 -AA4 AA4 vanillyl-alcohol oxidase (EC 1.1.3.38) Auxiliary Activities carbon utilization CAZY Polyphenolics Cleavage 0 0 -AA5 AA5 Oxidase with oxygen as acceptor (EC 1.1.3.-); galactose oxidase (EC 1.1.3.9); glyoxal oxidase (EC 1.2.3.15); alcohol oxidase (EC 1.1.3.13) Auxiliary Activities carbon utilization CAZY 0 0 -AA6 AA6 1,4-benzoquinone reductase (EC. 1.6.5.6) Auxiliary Activities carbon utilization CAZY 0 0 -AA7 AA7 glucooligosaccharide oxidase (EC 1.1.3.-); chitooligosaccharide oxidase (EC 1.1.3.-) Auxiliary Activities carbon utilization CAZY 0 0 -AA8 AA8 Iron reductase domain Auxiliary Activities carbon utilization CAZY 0 0 -AA9 AA9 (formerly GH61) proteins are copper-dependent lytic polysaccharide monooxygenases (LPMOs); cleavage of cellulose chains with oxidation of carbons C1 and/or C4 and C-6); lytic cellulose monooxygenase (C1-hydroxylating) (EC 1.14.99.54); lytic cellulose monooxygenase (C4-dehydrogenating) (EC 1.14.99.56) Auxiliary Activities carbon utilization CAZY Crystalline Cellulose Backbone Cleavage, Xyloglucan Backbone Cleavage (Hemicellulose) 0 0 -CBM0 CBM0 Carbohydrate-binding modules not yet assigned to a family. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM10 CBM10 Modules of approx. 50 residues. The cellulose-binding function has been demonstrated in one case. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM11 CBM11 Modules of approx. 180-200 residues. The CBM11 of Clotridium thermocellum Cel26A-Cel5E has been shown to bind both beta-1,4-glucan and beta-1,3-1,4-mixed linked glucans. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM12 CBM12 Modules of approx. 40-60 residues. The majority of these modules is found among chitinases where the function is chitin-binding. Distantly related to the CBM5 family. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM13 CBM13 Modules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM14 CBM14 Modules of approx. 70 residues. The chitin-binding function has been demonstrated in several cases. These modules are found attached to a number of chitinase catalytic domains, but also in non-catalytic proteins either in isolation or as multiple repeats; chitin binding (EC IIa.chitin) Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM15 CBM15 Binding to xylan and xylooligosaccharides has been demonstrated in the case of Xyn10C of Cellvibrio mixtus. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM16 CBM16 Carbohydrate-binding module 16. Binding to cellulose and glucomannan demonstrated [B. Bae et al (2008) J Biol Chem. 283:12415-25 (PMID: 18025086)] Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM17 CBM17 Modules of approx. 200 residues. Binding to amorphous cellulose, cellooligosaccharides and derivatized cellulose has been demonstrated. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM18 CBM18 Modules of approx. 40 residues. The chitin-binding function has been demonstrated in many cases. These modules are found attached to a number of chitinase catalytic domains, but also in non-catalytic proteins either in isolation or as multiple repeats. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM19 CBM19 Modules of 60-70 residues with chitin-binding function. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM1 CBM1 Modules of approx. 40 residues found almost exclusively in fungi. The cellulose-binding function has been demonstrated in many cases, and appears to be mediated by three aromatic residues separated by about 10.4 angstrom and which form a flat surface. The only non-fungal occurence of CBM1 is in an algal non-hydrolytic polysaccharide-binding protein which is composed of four repeated CBM1 modules. Binding to chitin has been demonstrated in one case. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM20 CBM20 The granular starch-binding function has been demonstrated in several cases. Interact strongly with cyclodextrins. Often designated as starch-binding domains (SBD). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM21 CBM21 Modules of approx. 100 residues. The granular starch-binding function has been demonstrated in one case. Sometimes designated as starch-binding domains (SBD). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM22 CBM22 A xylan binding function has been demonstrated in several cases and affinity with mixed beta-1,3/beta-1,4-glucans in one. In several cases a thermostabilizing effect has also been seen. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM23 CBM23 Mannan-binding function demonstrated in one case. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM24 CBM24 alpha-1,3-glucan (mutan)-binding function demonstrated in two cases (PMID:10636904) Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM25 CBM25 Starch-binding function demonstrated in one case. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM26 CBM26 Starch-binding function demonstrated in two cases. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM27 CBM27 Mannan-binding function demonstrated in two cases Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM28 CBM28 The module from the endo-1,4-glucanase of Bacillus sp. 1139 binds to non-crystalline cellulose, cellooligosaccharides, and beta-(1,3)(1,4)-glucans Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM29 CBM29 Binding to mannan/glucomannan has been demonstrated. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM2 CBM2 Modules of approx. 100 residues and which are found in a large number of bacterial enzymes. The cellulose-binding function has been demonstrated in many cases. Several of these modules have been shown to also bind chitin or xylan. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM30 CBM30 Binding to cellulose has been demonstrated for the N-terminal module of Fibrobacter succinogenes CelF. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM31 CBM31 Binding to beta-1,3-xylan has been demonstrated for the C-terminal module of the beta-1,3-xylanase of Alcaligenes sp. XY234. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM32 CBM32 Binding to galactose and lactose has been demonstrated for the module of Micromonospora viridifaciens sialidase (PMID: 16239725). Binding to polygalacturonic acid has been shown for a Yersinia member (PMID: 17292916). Binding to LacNAc (beta-D-galactosyl-1,4-beta-D-N-acetylglucosamine) has been shown for an N-acetylglucosaminidase from Clostridium perfingens (PMID: 16990278). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM33 CBM33 Copper-dependent lytic polysaccharide monooxygenases now reclassified in family AA10 Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM34 CBM34 Modules of approx. 120 residues. Granular starch-binding function has been demonstrated in the case of Thermoactinomyces vulgaris R-47 α-amylase 1 (TVAI). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM35 CBM35 Modules of approx. 130 residues. A module that is conserved in three Cellvibrio xylan-degrading enzymes binds to xylan and the interaction is calcium dependent, while a module from a Cellvibrio mannanase binds to decorated soluble mannans and mannooligosaccharides. A module in a Phanerochaete chrysosporium galactan 1,3-beta-galactosidase binds to beta-galactan. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM36 CBM36 Modules of approx. 120-130 residues displaying structural similarities to CBM6 modules. The only CBM36 currently characterised, that from Paenbacillus polymyxa xylanase 43A, shows calcium-dependent binding of xylans and xylooligosaccharides. X-ray crystallography shows that there is a direct interaction between calcium and ligand. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM37 CBM37 Modules of approx. 100 residues, conserved in numerous R. albus polysaccharide-degrading enzymes and other proteins from this bacterium. Several members of CBM37 have been shown to exhibit rather broad binding specificity to xylan, chitin, microcrystalline and phosphoric-acid swollen cellulose, as well as more heterogeneous substrates, such as alfalfa cell walls, banana stem and wheat straw. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM38 CBM38 The inulin-binding function has been demonstrated in the case of the cycloinulo-oligosaccharide fructanotransferase from Paenibacillus macerans (Bacillus macerans) by Lee et al. (2004) FEMS Microbiol Lett 234:105-10. (PMID:15109727). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM39 CBM39 Modules generally found at the N-terminus of a GH16 module (itself frequently lacking a catalytic machinery) and more seldomly in isolation. The beta-1,3-glucan binding function has been demonstrated, along with binding to lipopolysaccharide and lipoteichoic acid. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM3 CBM3 Modules of approx. 150 residues found in bacterial enzymes. The cellulose-binding function has been demonstrated in many cases. In one instance binding to chitin has been reported. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM40 CBM40 Modules of approx. 200 residues, found at the N-terminus of GH33 sialidases. Can also be found inserted in the beta-propeller of GH33 sialidases. The sialic acid binding function has been demonstrated for the N-terminal CBM40 of Vibrio cholerae sialidase (Moustafa et al. (2004) J Biol Chem 279:40819-26) (PMID: 15226294). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM41 CBM41 Modules of approx. 100 residues found in primarily in bacterial pullulanases. The N-terminal module from Thermotoga maritima Pul13 has been shown to bind to the alpha-glucans amylose, amylopectin, pullulan, and oligosaccharide fragments derived from these polysaccharides (Lammerts van Bueren et al. (2004) Biochemistry 43:15633-42) (PMID: 15581376). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM42 CBM42 Modules of approx. 160 residues found mostly at the C-terminus of GH54 catalytic domains. Binding to arabinofuranose (present in arabinoxylan) has been demonstrated. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM43 CBM43 Modules of approx. 90-100 residues found at the C-terminus of GH17 or GH72 enzymatic modules and also sometimes isolated. CBM43 modules sometimes carry a C-terminal membrane anchor. The beta-1,3-glucan binding function has been demonstrated with the olive pollen protein Ole e 10. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM44 CBM44 The C-terminal CBM44 module of the Clostridium thermocellum enzyme has been demonstrated to bind equally well cellulose and xyloglucan Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM45 CBM45 Modules of approx. 100 residues, found at the N-terminus of plastidial alpha-amylases and of alpha-glucan, water dikinases. Starch-binding activity demonstrated in the case of potato alpha-glucan, water dikinase. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM46 CBM46 Modules of approx. 100 residues, found at the C-terminus of several GH5 cellulases. Cellulose-binding function demonstrated in one case. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM47 CBM47 Modules of approx 150 residues. Fucose-binding activity demonstrated Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM48 CBM48 Modules of approx. 100 residues with glycogen-binding function, appended to GH13 modules. Also found in the beta subunit (glycogen-binding) of AMP-activated protein kinases (AMPK) Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM49 CBM49 Modules of approx. 100 residues found at the C-terminus of plant GH9 enzymes. Distantly related to CBM2 modules. Binding to crystalline cellulose demonstrated in the case of Solanum lycopersicum Cel8 enzyme (SlCel9C1). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM4 CBM4 Modules of approx. 150 residues found in bacterial enzymes. Binding of these modules has been demonstrated with xylan, beta-1,3-glucan, beta-1,3-1,4-glucan, beta-1,6-glucan and amorphous cellulose but not with crystalline cellulose. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM50 CBM50 Modules of approx. 50 residues found attached to various enzymes from families GH18, GH19, GH23, GH24, GH25 and GH73, i.e. enzymes cleaving either chitin or peptidoglycan. Binding to chitopentaose demonstrated in the case of Pteris ryukyuensis chitinase A [Ohnuma T et al. (2008) J. Biol. Chem. 283:5178-87 (PMID: 18083709)]. CBM50 modules are also found in a multitude of other enzymes targeting the petidoglycan such as peptidases and amidases. These enzymes are not reported in the list below. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM51 CBM51 Modules of approx. 150 residues found attached to various enzymes from families GH2, GH27, GH31, GH95, GH98 and GH101 . Binding to galactose and to blood group A/B-antigens demonstrated in the case of C. perfringens GH95CBM51 and GH98CBM51 respectively [Gregg KJ et al. (2008) J. Biol. Chem. 283:12604-13 PMID: 18292090]. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM52 CBM52 Modules of approx. 60 residues attached to a few GH81 enzymes but present in other proteins. Binding to beta-1,3-glucan demonstrated for Schizosaccharomyces pombe 972h- endo-1,3-beta-glucanase Eng1 [Martin-Quadrado et al., Mol. Microbiol. (2008) 69:188-200 PMID:18466295] Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM53 CBM53 Starch-binding function demonstrated by Valdez et al. (2008) [PMID: 18260645] Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM54 CBM54 Binding to xylan, yeast cell wall glucan and chitin shown in Dvortsov et al., Microbiology UK (2009) in press. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM55 CBM55 Binding to chitin demonstrated in the case of the CBM55 of Entamoeba histolytica chitinase (Van Dellen et al. (2002) Infect Immun. 70:3259–3263; PMID: 12011021). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM56 CBM56 beta-1,3-glucan binding function demonstrated by Yamamoto et al. (1998) FEBS Letters 433:41-43 [PMID: 9738929] Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM57 CBM57 Created from reading Schallus et al (2008) Mol Biol Cell. 19:3404-3414 [PMID: 18524852] and finding related domains attached to various glycosidases. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM58 CBM58 The CBM58 module of the Bacteroides thetaiotaomicron SusG protein has been shown to bind maltoheptaose Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM59 CBM59 Binding to mannan, xylan, and cellulose demonstrated for the CBM59 of ManF-X10 xylanase from an environmental genomic DNA library (Li et al. (2009) World Journal of Microbiology and Biotechnology 25:2071-2078; doi:10.1007/s11274-009-0111-6) Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM5 CBM5 Modules of approx. 60 residues found in bacterial enzymes. Chitin-binding described in several cases. Distantly related to the CBM12 family. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM60 CBM60 Modules of approx 120 residues usually found appended to xylanases. The xylan-binding function and the relatedness (circular permutation) to family CBM36 has been demonstrated [PMID: 20659893]. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM61 CBM61 Modules of approx. 150 residues found appended to GH16, GH30, GH31, GH43, GH53 and GH66 catalytic domains. A beta-1,4-galactan binding function has been demonstrated for the CBM61 of Thermotoga maritima GH53 galactanase [PMID: 20826814]. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM62 CBM62 The CBM62 module of Clostridium thermocellum Cthe_2193 protein binds galactose moieties found on xyloglucan, arabinogalactan and galactomannan. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM63 CBM63 The CBM63 module of Bacillus subtilis expansin EXLX1 has been shown to bind cellulose. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM64 CBM64 Module found at C-term of several Spirochaeta thermophila proteins. Binding to cellulose shown by Angelov, Loderer, Pompei Liebl (2011) AEM, 77:5483-5489 [PMID - 21685171] Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM65 CBM65 CBM65A and CBM65B, derived from Eubacterium cellulosolvens endoglucanase EcCel5A, bind to a range of beta-glucans but, uniquely, display significant preference for xyloglucan Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM66 CBM66 The CBM66 module, derived from the Bacillus subtilis exo-acting beta-fructosidase SacC, targets the terminal fructoside residue of fructans. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM67 CBM67 Fujimoto et al. [PMID : 23486481] disclosed the L-rhamnose binding activity and 3-D structure of the CBM67 of Streptomyces avermitilis alpha-L-rhamnosidase (SaRha78A); Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM68 CBM68 Binding to maltotriose and maltotetraose shown for the pullulanase of Anoxybacillus sp. LM18-11. Binding function derived from crystal structure and deletion of the CBM, which showed reduced specific activity and increased Km value compared to the wild type enzyme. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM69 CBM69 starch-binding function demonstrated in one case; distantly related to families CBM20 and CBM48 Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM6 CBM6 Modules of approx. 120 residues. The cellulose-binding function has been demonstrated in one case on amorphous cellulose and beta-1,4-xylan. Some of these modules also bind beta-1,3-glucan, beta-1,3-1,4-glucan, and beta-1,4-glucan. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM70 CBM70 The hyaluronan-specific binding function of the N-terminal CBM70 module of Streptococcus pneumoniae hyaluronate lyase has been demonstrated. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM71 CBM71 The two CBM71s of S. pneumoniae BgaA bind lactose and LacNAc. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM72 CBM72 Modules of 130-180 residues found at the C-terminus glycoside hydrolases from various families, sometimes as tandem repeats. The CBM72 found on an endoglucanase from an uncultivated microorganism was found to bind a broad spectrum of polysaccharides including soluble and insoluble cellulose, beta-1,3/1,4-mixed linked glucans, xylan, and beta-mannan [PMID=26765840]. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM73 CBM73 Modules of approx 65 residues found on various enzymes active of chitin. Chitin-binding function demonstrated for the Cellvibrio japonicus CjLPMO10A protein. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM74 CBM74 Modules of approx. 300 residues appended to several alpha-amylases. The starch-binding function has been demonstrated for the CBM74 appended to the GH13 alpha-amylase of Microbacterium aureum B8.A Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM75 CBM75 Modules of 290 residues appended to GH43_16 enzymes. So far found exclusively in Ruminococci. The xyloglucan-binding function was demonstrated for the R. flavefaciens protein. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM76 CBM76 Modules of approx. 170 residues appended to GH44 enzymes. So far found exclusively in Ruminococci. Broad specificity binding to beta-glucans demontsrated for the R. flavefaciens module, which binds xyloglucan, glucomannan, and barley beta-glucan. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM77 CBM77 Pectin binding modules of approx. 110 residues. The Ruminococcus flavefaciens CBM77 was shown to bind various pectins of low degree of esterification. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM78 CBM78 Modules of approx. 150 residues appended to the C-terminus of GH5 and GH26 enzymes. So far found exclusively in Ruminococcal enzymes. The R. flavefaciens module has been shown to bind decorated beta-1,4-glucans with a preference for xyloglucan. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM79 CBM79 Modules of approx. 130 residues found so far only in ruminococcal proteins. Binding to various beta-glucans was shown for the R. flavefaciens GH9 enzyme. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM7 CBM7 Deleted entry Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM80 CBM80 Modules of approx. 90 residues found so far only in ruminococcal enzymes of families GH5 or GH26. Broad specificity for beta-glycans (xyloglucan, glucomannan, galactomannan, barley beta-glucan). Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM81 CBM81 Small family of modules of approx. 100 residues, appended to GH5_2 enzymes. So far found exclusively in a few gammaproteobacteria. The CBM81 from an uncultivated species was shown to have binding affinity for beta-1,4-, beta-1,3,-glucans, xyloglucan, avicel and cellooligosaccharides. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM82 CBM82 The boundaries, structure and starch-binding function of the CBM82 module of Eubacterium rectale Amy13K have been reported by Cockburn and coworkers in Molec. Microbiol. (2017) (PMID=29139580) Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM83 CBM83 The boundaries, structure and starch-binding function of the CBM83 module of Eubacterium rectale Amy13K have been reported by Cockburn and coworkers in Molec. Microbiol. (2017) (PMID=29139580) Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM84 CBM84 Modules of approx. 140 aminoacids appended to enzymes of different families of CAZymes. A xanthan-binding function was reported for the GH9 xanthanase of Paenibacillus nanensis by Moroz et al. ACS Catal., 2018, 8 (7), pp 6021-6034. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM85 CBM85 Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM8 CBM8 The cellulose-binding module from a cellulase of the slime mold Dictyostelium discoideum has been experimentally shown to bind cellulose. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CBM9 CBM9 Modules of approx. 170 residues found so far only in xylanases. The cellulose-binding function has been demonstrated in one case. Carbohydrate-Binding Modules carbon utilization CAZY 0 0 -CE0 CE0 See below. Carbohydrate Esterases carbon utilization CAZY 0 0 -CE10 CE10 arylesterase (EC 3.1.1.-); carboxyl esterase (EC 3.1.1.3); acetylcholinesterase (EC 3.1.1.7); cholinesterase (EC 3.1.1.8); sterol esterase (EC 3.1.1.13); brefeldin A esterase (EC 3.1.1.-). Carbohydrate Esterases carbon utilization CAZY 0 0 -CE11 CE11 UDP-3-0-acyl N-acetylglucosamine deacetylase (EC 3.5.1.108). Carbohydrate Esterases carbon utilization CAZY 0 0 -CE12 CE12 pectin acetylesterase (EC 3.1.1.-); rhamnogalacturonan acetylesterase (EC 3.1.1.-); acetyl xylan esterase (EC 3.1.1.72) Carbohydrate Esterases carbon utilization CAZY Pectin Oligo Cleavage 0 0 -CE13 CE13 pectin acetylesterase (EC 3.1.1.-) Carbohydrate Esterases carbon utilization CAZY 0 0 -CE14 CE14 N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase (EC 3.5.1.89); diacetylchitobiose deacetylase (EC 3.5.1.-); mycothiol S-conjugate amidase (EC 3.5.1.-) Carbohydrate Esterases carbon utilization CAZY 0 0 -CE15 CE15 4-O-methyl-glucuronoyl methylesterase (EC 3.1.1.-) Carbohydrate Esterases carbon utilization CAZY 0 0 -CE16 CE16 acetylesterase (EC 3.1.1.6) active on various carbohydrate acetyl esters Carbohydrate Esterases carbon utilization CAZY 0 0 -CE1 CE1 acetyl xylan esterase (EC 3.1.1.72); cinnamoyl esterase (EC 3.1.1.-); feruloyl esterase (EC 3.1.1.73); carboxylesterase (EC 3.1.1.1); S-formylglutathione hydrolase (EC 3.1.2.12); diacylglycerol O-acyltransferase (EC 2.3.1.20); trehalose 6-O-mycolyltransferase (EC 2.3.1.122) Carbohydrate Esterases carbon utilization CAZY 0 0 -CE2 CE2 acetyl xylan esterase (EC 3.1.1.72). Carbohydrate Esterases carbon utilization CAZY Beta-mannan Oligo Cleavage (Hemicellulose) 0 0 -CE3 CE3 acetyl xylan esterase (EC 3.1.1.72). Carbohydrate Esterases carbon utilization CAZY 0 0 -CE4 CE4 acetyl xylan esterase (EC 3.1.1.72); chitin deacetylase (EC 3.5.1.41); chitooligosaccharide deacetylase (EC 3.5.1.-); peptidoglycan GlcNAc deacetylase (EC 3.5.1.-); peptidoglycan N-acetylmuramic acid deacetylase (EC 3.5.1.-). Carbohydrate Esterases carbon utilization CAZY Chitin Oligo Cleavage 0 0 -CE5 CE5 acetyl xylan esterase (EC 3.1.1.72); cutinase (EC 3.1.1.74) Carbohydrate Esterases carbon utilization CAZY 0 0 -CE6 CE6 acetyl xylan esterase (EC 3.1.1.72). Carbohydrate Esterases carbon utilization CAZY 0 0 -CE7 CE7 acetyl xylan esterase (EC 3.1.1.72); cephalosporin-C deacetylase (EC 3.1.1.41). Carbohydrate Esterases carbon utilization CAZY 0 0 -CE8 CE8 pectin methylesterase (EC 3.1.1.11). Carbohydrate Esterases carbon utilization CAZY Pectin Oligo Cleavage 0 0 -CE9 CE9 N-acetylglucosamine 6-phosphate deacetylase (EC 3.5.1.25); N-acetylglucosamine 6-phosphate deacetylase (EC 3.5.1.80) Carbohydrate Esterases carbon utilization CAZY 0 0 -GH0 GH0 Glycoside hydrolases not yet assigned to a family. Glycoside Hydrolases carbon utilization CAZY 0 0 -GH100 GH100 alkaline and neutral invertase (EC 3.2.1.26) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH101 GH101 endo-alpha-N-acetylgalactosaminidase (EC 3.2.1.97) Glycoside Hydrolases carbon utilization CAZY Mucin Backbone Cleavage 0 0 -GH102 GH102 peptidoglycan lytic transglycosylase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH103 GH103 peptidoglycan lytic transglycosylase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH104 GH104 peptidoglycan lytic transglycosylase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH105 GH105 unsaturated rhamnogalacturonyl hydrolase (EC 3.2.1.172); d-4,5-unsaturated beta-glucuronyl hydrolase (EC 3.2.1.-); d-4,5-unsaturated alpha-galacturonidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Pectin Oligo Cleavage 0 0 -GH106 GH106 alpha-L-rhamnosidase (EC 3.2.1.40); rhamnogalacturonan alpha-L-rhamnohydrolase (EC 3.2.1.174) Glycoside Hydrolases carbon utilization CAZY Pectin Oligo Cleavage, Rhamnose Oligo cleavage 0 0 -GH107 GH107 sulfated fucan endo-1,4-fucanase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Fucose Oligo Cleavage 0 0 -GH108 GH108 N-acetylmuramidase (EC 3.2.1.17) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH109 GH109 alpha-N-acetylgalactosaminidase (EC 3.2.1.49) Glycoside Hydrolases carbon utilization CAZY Mucin Oligo Cleavage 0 0 -GH10 GH10 endo-1,4-beta-xylanase (EC 3.2.1.8); endo-1,3-beta-xylanase (EC 3.2.1.32); tomatinase (EC 3.2.1.-); xylan endotransglycosylase (EC 2.4.2.-); endo-beta-1,4-glucanase (EC 3.2.1.4) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Backbone Cleavage, Xyloglucan Oligo Cleavage (Hemicellulose), Xylan Backbone Cleavage (Hemicellulose) 0 0 -GH110 GH110 alpha-galactosidase (EC 3.2.1.22); alpha-1,3-galactosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Alpha-galactans Oligo Cleavage 0 0 -GH111 GH111 keratan sulfate hydrolase (endo-beta-N-acetylglucosaminidase) (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -GH112 GH112 lacto-N-biose phosphorylase or galacto-N-biose phosphorylase (EC 2.4.1.211); D-galactosyl-beta-1,4-L-rhamnose phosphorylase (EC 2.4.1.247); galacto-N-biose/lacto-N-biose phosphorylase (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY Mucin Oligo Cleavage 0 0 -GH113 GH113 beta-mannanase (EC 3.2.1.78) Glycoside Hydrolases carbon utilization CAZY Beta-mannan Backbone Cleavage (Hemicellulose), Beta-mannan Oligo Cleavage (Hemicellulose) 0 0 -GH114 GH114 endo-alpha-1,4-polygalactosaminidase (EC 3.2.1.109) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH115 GH115 xylan alpha-1,2-glucuronidase (3.2.1.131); alpha-(4-O-methyl)-glucuronidase (3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Xylan Oligo Cleavage (Hemicellulose) 0 0 -GH116 GH116 beta-glucosidase (EC 3.2.1.21); beta-xylosidase (EC 3.2.1.37); acid beta-glucosidase/beta-glucosylceramidase (EC 3.2.1.45); beta-N-acetylglucosaminidase (EC 3.2.1.52) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Oligo Cleavage, Chitin Oligo Cleavage 0 0 -GH117 GH117 alpha-1,3-L-neoagarooligosaccharide hydrolase (EC 3.2.1.-); alpha-1,3-L-neoagarobiase / neoagarobiose hydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Sulf-Polysachharides Oligo Cleavage 0 0 -GH118 GH118 beta-agarase (EC 3.2.1.81) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH119 GH119 alpha-amylase (EC 3.2.1.1) Glycoside Hydrolases carbon utilization CAZY Starch Backbone Cleavage 0 0 -GH11 GH11 endo-beta-1,4-xylanase (EC 3.2.1.8); endo-beta-1,3-xylanase (EC 3.2.1.32) Glycoside Hydrolases carbon utilization CAZY Xylan Backbone Cleavage (Hemicellulose) 0 0 -GH120 GH120 beta-xylosidase (EC 3.2.1.37) Glycoside Hydrolases carbon utilization CAZY Xylan Oligo Cleavage (Hemicellulose) 0 0 -GH121 GH121 beta-L-arabinobiosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Arabinose Oligo cleavage 0 0 -GH122 GH122 alpha-glucosidase (EC 3.2.1.20) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH123 GH123 beta-N-acetylgalactosaminidase (EC 3.2.1.53); glycosphingolipid beta-N-acetylgalactosaminidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH124 GH124 endoglucanase (EC 3.2.1.4) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Backbone Cleavage 0 0 -GH125 GH125 exo-alpha-1,6-mannosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Alpha-mannan Oligo Cleavage (Hemicellulose) 0 0 -GH126 GH126 alpha-amylase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Starch Backbone Cleavage 0 0 -GH127 GH127 beta-L-arabinofuranosidase (EC 3.2.1.185); 3-C-carboxy-5-deoxy-L-xylose (aceric acid) hydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Arabinose Oligo cleavage 0 0 -GH128 GH128 beta-1,3-glucanase (EC 3.2.1.39) Glycoside Hydrolases carbon utilization CAZY Mixed-Linkage glucans Backbone Cleavage (Hemicellulose), Rhamnose Oligo cleavage 0 0 -GH129 GH129 alpha-N-acetylgalactosaminidase (EC 3.2.1.49); Glycoside Hydrolases carbon utilization CAZY Mucin Oligo Cleavage 0 0 -GH12 GH12 endoglucanase (EC 3.2.1.4); xyloglucan hydrolase (EC 3.2.1.151); beta-1,3-1,4-glucanase (EC 3.2.1.73); xyloglucan endotransglycosylase (EC 2.4.1.207) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Backbone Cleavage, Xyloglucan Backbone Cleavage (Hemicellulose) 0 0 -GH130 GH130 beta-1,4-mannosylglucose phosphorylase (EC 2.4.1.281); beta-1,4-mannooligosaccharide phosphorylase (EC 2.4.1.319); beta-1,4-mannosyl-N-acetyl-glucosamine phosphorylase (EC 2.4.1.320); beta-1,2-mannobiose phosphorylase (EC 2.4.1.-); beta-1,2-oligomannan phosphorylase (EC 2.4.1.-); beta-1,2-mannosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Alpha-mannan Oligo Cleavage (Hemicellulose), Beta-mannan Oligo Cleavage (Hemicellulose) 0 0 -GH131 GH131 broad specificity exo-beta-1,3/1,6-glucanase with endo-beta-1,4-glucanase activity (EC 3.2.1.-); Glycoside Hydrolases carbon utilization CAZY 0 0 -GH132 GH132 Activity on beta-1,3-glucan (curdlan) shown for the Aspergillus fumigatus Sun4 protein; activity on laminarioligosaccharides shown for Aspergillus fumigatus Sun4 protein and Candida albicans Sun41 protein; transglycosylation activity reported in PMID 23508952. Glycoside Hydrolases carbon utilization CAZY 0 0 -GH133 GH133 amylo-alpha-1,6-glucosidase (EC 3.2.1.33); Glycoside Hydrolases carbon utilization CAZY Starch Oligo Cleavage 0 0 -GH134 GH134 endo-beta-1,4-mannanase (EC 3.2.1.78); Glycoside Hydrolases carbon utilization CAZY Beta-mannan Backbone Cleavage (Hemicellulose) 0 0 -GH135 GH135 alpha-1,4-galactosaminogalactan hydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH136 GH136 lacto-N-biosidase (EC 3.2.1.140) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH137 GH137 beta-L-arabinofuranosidase (EC 3.2.1.185) Glycoside Hydrolases carbon utilization CAZY Arabinose Oligo cleavage 0 0 -GH138 GH138 alpha-galacturonidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Pectin Oligo Cleavage 0 0 -GH139 GH139 alpha-2-O-Me-L-fucosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Pectin Oligo Cleavage, Fucose Oligo Cleavage 0 0 -GH13 GH13 alpha-amylase (EC 3.2.1.1); pullulanase (EC 3.2.1.41); cyclomaltodextrin glucanotransferase (EC 2.4.1.19); cyclomaltodextrinase (EC 3.2.1.54); trehalose-6-phosphate hydrolase (EC 3.2.1.93); oligo-alpha-glucosidase (EC 3.2.1.10); maltogenic amylase (EC 3.2.1.133); neopullulanase (EC 3.2.1.135); alpha-glucosidase (EC 3.2.1.20); maltotetraose-forming alpha-amylase (EC 3.2.1.60); isoamylase (EC 3.2.1.68); glucodextranase (EC 3.2.1.70); maltohexaose-forming alpha-amylase (EC 3.2.1.98); maltotriose-forming alpha-amylase (EC 3.2.1.116); branching enzyme (EC 2.4.1.18); trehalose synthase (EC 5.4.99.16); 4-alpha-glucanotransferase (EC 2.4.1.25); maltopentaose-forming alpha-amylase (EC 3.2.1.-) ; amylosucrase (EC 2.4.1.4) ; sucrose phosphorylase (EC 2.4.1.7); malto-oligosyltrehalose trehalohydrolase (EC 3.2.1.141); isomaltulose synthase (EC 5.4.99.11); malto-oligosyltrehalose synthase (EC 5.4.99.15); amylo-alpha-1,6-glucosidase (EC 3.2.1.33); alpha-1,4-glucan: phosphate alpha-maltosyltransferase (EC 2.4.99.16); 6'-P-sucrose phosphorylase (EC 2.4.1.-); amino acid transporter Glycoside Hydrolases carbon utilization CAZY Starch Backbone Cleavage 0 0 -GH140 GH140 apiosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH141 GH141 alpha-L-fucosidase (EC 3.2.1.51); xylanase (EC 3.2.1.8) Glycoside Hydrolases carbon utilization CAZY Xylan Backbone Cleavage (Hemicellulose), Fucose Oligo Cleavage 0 0 -GH142 GH142 beta-L-arabinofuranosidase (EC 3.2.1.185) Glycoside Hydrolases carbon utilization CAZY Arabinose Oligo cleavage 0 0 -GH143 GH143 2-keto-3-deoxy-D-lyxo-heptulosaric acid hydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Pectin Oligo Cleavage 0 0 -GH144 GH144 endo-beta-1,2-glucanase (EC 3.2.1.71); beta-1,2-glucooligosaccharide sophorohydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH145 GH145 L-Rhalpha-alpha-1,4-GlcA alpha-L-rhamnohydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Rhamnose Oligo cleavage 0 0 -GH146 GH146 beta-L-arabinofuranosidase (EC 3.2.1.185) Glycoside Hydrolases carbon utilization CAZY Arabinose Oligo cleavage 0 0 -GH147 GH147 beta-galactosidase (EC 3.2.1.23) Glycoside Hydrolases carbon utilization CAZY Beta-galactan (pectic galactan) Oligo Cleavage 0 0 -GH148 GH148 beta-1,3-glucanase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH149 GH149 beta-1,3-glucan phosphorylase (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH14 GH14 beta-amylase (EC 3.2.1.2) Glycoside Hydrolases carbon utilization CAZY Starch Backbone Cleavage 0 0 -GH150 GH150 l-carrageenase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -GH151 GH151 alpha-L-fucosidase (EC 3.2.1.51) Glycoside Hydrolases carbon utilization CAZY Fucose Oligo Cleavage 0 0 -GH152 GH152 beta-1,3-glucanase (EC 3.2.1.39) Glycoside Hydrolases carbon utilization CAZY Mixed-Linkage glucans Backbone Cleavage (Hemicellulose) 0 0 -GH153 GH153 poly-beta-1,6-D-glucosamine hydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH154 GH154 beta-glucuronidase (3.2.1.31) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH155 GH155 Deleted family! Glycoside Hydrolases carbon utilization CAZY 0 0 -GH156 GH156 exo-alpha-sialidase (EC 3.2.1.18); Glycoside Hydrolases carbon utilization CAZY 0 0 -GH157 GH157 endo-beta-1,3-glucanase (EC 3.2.1.39); endo-beta-1,3-glucanase / laminarinase (EC 3.2.1.39) Glycoside Hydrolases carbon utilization CAZY Mixed-Linkage glucans Backbone Cleavage (Hemicellulose) 0 0 -GH158 GH158 endo-beta-1,3-glucanase (EC 3.2.1.39) Glycoside Hydrolases carbon utilization CAZY Mixed-Linkage glucans Backbone Cleavage (Hemicellulose) 0 0 -GH159 GH159 beta-D-galactofuranosidase (EC 3.2.1.146) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH15 GH15 glucoamylase (EC 3.2.1.3); glucodextranase (EC 3.2.1.70); alpha,alpha-trehalase (EC 3.2.1.28); dextran dextrinase (EC 2.4.1.2) Glycoside Hydrolases carbon utilization CAZY Starch Oligo Cleavage 0 0 -GH160 GH160 endo-beta-1,4-galactosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH161 GH161 beta-1,3-glucan phosphorylase (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH162 GH162 endo-beta-1,2-glucanase (EC 3.2.1.71) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH163 GH163 endo-beta-N-acetylglucosaminidase cleaving GlcNAc-beta-1,2-Man (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH164 GH164 beta-mannosidase (EC 3.2.1.25); beta-mannosidase (EC 3.2.1.25) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH165 GH165 beta-galactosidase (EC 3.2.1.23) Glycoside Hydrolases carbon utilization CAZY Beta-galactan (pectic galactan) Oligo Cleavage 0 0 -GH16 GH16 xyloglucan:xyloglucosyltransferase (EC 2.4.1.207); keratan-sulfate endo-1,4-beta-galactosidase (EC 3.2.1.103); endo-1,3-beta-glucanase / laminarinase (EC 3.2.1.39); endo-1,3(4)-beta-glucanase (EC 3.2.1.6); licheninase (EC 3.2.1.73); beta-agarase (EC 3.2.1.81); kappa;-carrageenase (EC 3.2.1.83); xyloglucanase (EC 3.2.1.151); endo-beta-1,3-galactanase (EC 3.2.1.181); [retaining] beta-porphyranase (EC 3.2.1.178); hyaluronidase (EC 3.2.1.35); endo-beta-1,4-galactosidase (EC 3.2.1.-); chitin beta-1,6-glucanosyltransferase (EC 2.4.1.-); beta-transglycosidase (EC 2.4.1.-); beta-glycosidase (EC 3.2.1.-); endo-beta-1,3-galactanase (EC 3.2.1.181) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Oligo Cleavage, Xyloglucan Backbone Cleavage (Hemicellulose), Mixed-Linkage glucans Backbone Cleavage (Hemicellulose), Mixed-Linkage glucans Oligo Cleavage (Hemicellulose), Sulf-Polysachharides Backbone Cleavage 0 0 -GH17 GH17 glucan endo-1,3-beta-glucosidase (EC 3.2.1.39); glucan 1,3-beta-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); ABA-specific beta-glucosidase (EC 3.2.1.175); beta-1,3-glucanosyltransglycosylase (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY Mixed-Linkage glucans Backbone Cleavage (Hemicellulose), Mixed-Linkage glucans Oligo Cleavage (Hemicellulose) 0 0 -GH18 GH18 chitinase (EC 3.2.1.14); lysozyme (EC 3.2.1.17); endo-beta-N-acetylglucosaminidase (EC 3.2.1.96); peptidoglycan hydrolase with endo-beta-N-acetylglucosaminidase specificity (EC 3.2.1.-); Nod factor hydrolase (EC 3.2.1.-); xylanase inhibitor; concanavalin B; narbonin Glycoside Hydrolases carbon utilization CAZY Chitin Backbone Cleavage 0 0 -GH19 GH19 chitinase (EC 3.2.1.14); lysozyme (EC 3.2.1.17) Glycoside Hydrolases carbon utilization CAZY Chitin Backbone Cleavage 0 0 -GH1 GH1 beta-glucosidase (EC 3.2.1.21); beta-galactosidase (EC 3.2.1.23); beta-mannosidase (EC 3.2.1.25); beta-glucuronidase (EC 3.2.1.31); beta-xylosidase (EC 3.2.1.37); beta-D-fucosidase (EC 3.2.1.38); phlorizin hydrolase (EC 3.2.1.62); exo-beta-1,4-glucanase (EC 3.2.1.74); 6-phospho-beta-galactosidase (EC 3.2.1.85); 6-phospho-beta-glucosidase (EC 3.2.1.86); strictosidine beta-glucosidase (EC 3.2.1.105); lactase (EC 3.2.1.108); amygdalin beta-glucosidase (EC 3.2.1.117); prunasin beta-glucosidase (EC 3.2.1.118); vicianin hydrolase (EC 3.2.1.119); raucaffricine beta-glucosidase (EC 3.2.1.125); thioglucosidase (EC 3.2.1.147); beta-primeverosidase (EC 3.2.1.149); isoflavonoid 7-O-beta-apiosyl-beta-glucosidase (EC 3.2.1.161); ABA-specific beta-glucosidase (EC 3.2.1.175); DIMBOA beta-glucosidase (EC 3.2.1.182); beta-glycosidase (EC 3.2.1.-); hydroxyisourate hydrolase (EC 3.-.-.-) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Oligo Cleavage, Mixed-Linkage glucans Oligo Cleavage (Hemicellulose), Beta-galactan (pectic galactan) Oligo Cleavage 0 0 -GH20 GH20 beta-hexosaminidase (EC 3.2.1.52); lacto-N-biosidase (EC 3.2.1.140); beta-1,6-N-acetylglucosaminidase (EC 3.2.1.-); beta-6-SO3-N-acetylglucosaminidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Chitin Oligo Cleavage 0 0 -GH21 GH21 Deleted family! Glycoside Hydrolases carbon utilization CAZY 0 0 -GH22 GH22 lysozyme type C (EC 3.2.1.17); lysozyme type i (EC 3.2.1.17); alpha-lactalbumin Glycoside Hydrolases carbon utilization CAZY 0 0 -GH23 GH23 lysozyme type G (EC 3.2.1.17); peptidoglycan lyase (EC 4.2.2.n1) also known in the literature as peptidoglycan lytic transglycosylase; chitinase (EC 3.2.1.14) Glycoside Hydrolases carbon utilization CAZY Chitin Backbone Cleavage 0 0 -GH24 GH24 lysozyme (EC 3.2.1.17) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH25 GH25 lysozyme (EC 3.2.1.17) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH26 GH26 beta-mannanase (EC 3.2.1.78); exo-beta-1,4-mannobiohydrolase (EC 3.2.1.100); beta-1,3-xylanase (EC 3.2.1.32); lichenase / endo-beta-1,3-1,4-glucanase (EC 3.2.1.73); mannobiose-producing exo-beta-mannanase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Xylan Backbone Cleavage (Hemicellulose), Beta-mannan Backbone Cleavage (Hemicellulose), Beta-mannan Oligo Cleavage (Hemicellulose) 0 0 -GH27 GH27 alpha-galactosidase (EC 3.2.1.22); alpha-N-acetylgalactosaminidase (EC 3.2.1.49); isomalto-dextranase (EC 3.2.1.94); beta-L-arabinopyranosidase (EC 3.2.1.88); galactan:galactan galactosyltransferase (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY Alpha-galactans Oligo Cleavage, Mucin Oligo Cleavage 0 0 -GH28 GH28 polygalacturonase (EC 3.2.1.15); alpha-L-rhamnosidase (EC 3.2.1.40); exo-polygalacturonase (EC 3.2.1.67); exo-polygalacturonosidase (EC 3.2.1.82); rhamnogalacturonase (EC 3.2.1.171); rhamnogalacturonan alpha-1,2-galacturonohydrolase (EC 3.2.1.173); endo-xylogalacturonan hydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -GH29 GH29 alpha-L-fucosidase (EC 3.2.1.51); alpha-1,3/1,4-L-fucosidase (EC 3.2.1.111) Glycoside Hydrolases carbon utilization CAZY Fucose Oligo Cleavage 0 0 -GH2 GH2 beta-galactosidase (EC 3.2.1.23) ; beta-mannosidase (EC 3.2.1.25); beta-glucuronidase (EC 3.2.1.31); alpha-L-arabinofuranosidase (EC 3.2.1.55); mannosylglycoprotein endo-beta-mannosidase (EC 3.2.1.152); exo-beta-glucosaminidase (EC 3.2.1.165); alpha-L-arabinopyranosidase (EC 3.2.1.-); beta-galacturonidase (EC 3.2.1.-); beta-xylosidase (EC 3.2.1.37); beta-D-galactofuranosidase (EC 3.2.1.146); Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Oligo Cleavage, Xyloglucan Oligo Cleavage (Hemicellulose), Beta-mannan Oligo Cleavage (Hemicellulose), Pectin Oligo Cleavage, Beta-galactan (pectic galactan) Oligo Cleavage, Arabinose Oligo cleavage 0 0 -GH30 GH30 endo-beta-1,4-xylanase (EC 3.2.1.8); beta-glucosidase (3.2.1.21); beta-glucuronidase (EC 3.2.1.31); beta-xylosidase (EC 3.2.1.37); beta-fucosidase (EC 3.2.1.38); glucosylceramidase (EC 3.2.1.45); beta-1,6-glucanase (EC 3.2.1.75); glucuronoarabinoxylan endo-beta-1,4-xylanase (EC 3.2.1.136); endo-beta-1,6-galactanase (EC:3.2.1.164); [reducing end] beta-xylosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Xylan Backbone Cleavage (Hemicellulose), Mixed-Linkage glucans Backbone Cleavage (Hemicellulose) 0 0 -GH31 GH31 alpha-glucosidase (EC 3.2.1.20); alpha-galactosidase (EC 3.2.1.22); alpha-mannosidase (EC 3.2.1.24); alpha-1,3-glucosidase (EC 3.2.1.84); sucrase-isomaltase (EC 3.2.1.48) (EC 3.2.1.10); alpha-xylosidase (EC 3.2.1.177); alpha-glucan lyase (EC 4.2.2.13); isomaltosyltransferase (EC 2.4.1.-); oligosaccharide alpha-1,4-glucosyltransferase (EC 2.4.1.161); sulfoquinovosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Xyloglucan Oligo Cleavage (Hemicellulose), Xylan Oligo Cleavage (Hemicellulose), Alpha-galactans Oligo Cleavage, Alpha-galactans Oligo Cleavage, Mucin Oligo Cleavage 0 0 -GH32 GH32 invertase (EC 3.2.1.26); endo-inulinase (EC 3.2.1.7); beta-2,6-fructan 6-levanbiohydrolase (EC 3.2.1.64); endo-levanase (EC 3.2.1.65); exo-inulinase (EC 3.2.1.80); fructan beta-(2,1)-fructosidase/1-exohydrolase (EC 3.2.1.153); fructan beta-(2,6)-fructosidase/6-exohydrolase (EC 3.2.1.154); sucrose:sucrose 1-fructosyltransferase (EC 2.4.1.99); fructan:fructan 1-fructosyltransferase (EC 2.4.1.100); sucrose:fructan 6-fructosyltransferase (EC 2.4.1.10); fructan:fructan 6G-fructosyltransferase (EC 2.4.1.243); levan fructosyltransferase (EC 2.4.1.-); [retaining] sucrose:sucrose 6-fructosyltransferase (6-SST) (EC 2.4.1.-); cycloinulo-oligosaccharide fructanotransferase (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH33 GH33 sialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH34 GH34 sialidase or neuraminidase (EC 3.2.1.18) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH35 GH35 beta-galactosidase (EC 3.2.1.23); exo-beta-glucosaminidase (EC 3.2.1.165); exo-beta-1,4-galactanase (EC 3.2.1.-); beta-1,3-galactosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Beta-galactan (pectic galactan) Oligo Cleavage 0 0 -GH36 GH36 alpha-galactosidase (EC 3.2.1.22); alpha-N-acetylgalactosaminidase (EC 3.2.1.49); stachyose synthase (EC 2.4.1.67); raffinose synthase (EC 2.4.1.82) Glycoside Hydrolases carbon utilization CAZY Alpha-galactans Oligo Cleavage, Mucin Oligo Cleavage 0 0 -GH37 GH37 alpha,alpha-trehalase (EC 3.2.1.28). Glycoside Hydrolases carbon utilization CAZY 0 0 -GH38 GH38 alpha-mannosidase (EC 3.2.1.24); mannosyl-oligosaccharide alpha-1,2-mannosidase (EC 3.2.1.113); mannosyl-oligosaccharide alpha-1,3-1,6-mannosidase (EC 3.2.1.114); alpha-2-O-mannosylglycerate hydrolase (EC 3.2.1.170); mannosyl-oligosaccharide alpha-1,3-mannosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Alpha-mannan Oligo Cleavage (Hemicellulose) 0 0 -GH39 GH39 alpha-L-iduronidase (EC 3.2.1.76); beta-xylosidase (EC 3.2.1.37). Glycoside Hydrolases carbon utilization CAZY Xylan Oligo Cleavage (Hemicellulose) 0 0 -GH3 GH3 beta-glucosidase (EC 3.2.1.21); xylan 1,4-beta-xylosidase (EC 3.2.1.37); beta-glucosylceramidase (EC 3.2.1.45); beta-N-acetylhexosaminidase (EC 3.2.1.52); alpha-L-arabinofuranosidase (EC 3.2.1.55); glucan 1,3-beta-glucosidase (EC 3.2.1.58); glucan 1,4-beta-glucosidase (EC 3.2.1.74); isoprimeverose-producing oligoxyloglucan hydrolase (EC 3.2.1.120); coniferin beta-glucosidase (EC 3.2.1.126); exo-1,3-1,4-glucanase (EC 3.2.1.-); beta-N-acetylglucosaminide phosphorylases (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Oligo Cleavage, Xylan Oligo Cleavage (Hemicellulose), Mixed-Linkage glucans Oligo Cleavage (Hemicellulose), Arabinan Oligo Cleavage, Chitin Oligo Cleavage 0 0 -GH40 GH40 Deleted family! Glycoside Hydrolases carbon utilization CAZY 0 0 -GH41 GH41 Deleted family! Glycoside Hydrolases carbon utilization CAZY 0 0 -GH42 GH42 beta-galactosidase (EC 3.2.1.23); alpha-L-arabinopyranosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Beta-galactan (pectic galactan) Oligo Cleavage 0 0 -GH43 GH43 beta-xylosidase (EC 3.2.1.37); alpha-L-arabinofuranosidase (EC 3.2.1.55); xylanase (EC 3.2.1.8); alpha-1,2-L-arabinofuranosidase (EC 3.2.1.-); exo-alpha-1,5-L-arabinofuranosidase (EC 3.2.1.-); [inverting] exo-alpha-1,5-L-arabinanase (EC 3.2.1.-); beta-1,3-xylosidase (EC 3.2.1.-); [inverting] exo-alpha-1,5-L-arabinanase (EC 3.2.1.-); [inverting] endo-alpha-1,5-L-arabinanase (EC 3.2.1.99); exo-beta-1,3-galactanase (EC 3.2.1.145); beta-D-galactofuranosidase (EC 3.2.1.146) Glycoside Hydrolases carbon utilization CAZY Xyloglucan Oligo Cleavage (Hemicellulose), Arabinan Backbone Cleavage, Arabinan Oligo Cleavage 0 0 -GH44 GH44 endoglucanase (EC 3.2.1.4); xyloglucanase (EC 3.2.1.151) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Backbone Cleavage, Xyloglucan Backbone Cleavage (Hemicellulose) 0 0 -GH45 GH45 endoglucanase (EC 3.2.1.4); xyloglucan-specific endo-beta-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151); endo-beta-1,4-mannanase (EC 3.2.1.78) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Backbone Cleavage, Xyloglucan Backbone Cleavage (Hemicellulose) 0 0 -GH46 GH46 chitosanase (EC 3.2.1.132) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH47 GH47 alpha-mannosidase (EC 3.2.1.113) Glycoside Hydrolases carbon utilization CAZY Alpha-mannan Oligo Cleavage (Hemicellulose) 0 0 -GH48 GH48 reducing end-acting cellobiohydrolase (EC 3.2.1.176); endo-beta-1,4-glucanase (EC 3.2.1.4); chitinase (EC 3.2.1.14) Glycoside Hydrolases carbon utilization CAZY Crystalline Cellulose Backbone Cleavage, Xyloglucan Backbone Cleavage (Hemicellulose) 0 0 -GH49 GH49 dextranase (EC 3.2.1.11); isopullulanase (EC 3.2.1.57); dextran 1,6-alpha-isomaltotriosidase (EC 3.2.1.95); sulfated arabinan endo-1,4-beta-L-arabinanase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Arabinan Backbone Cleavage 0 0 -GH4 GH4 maltose-6-phosphate glucosidase (EC 3.2.1.122); alpha-glucosidase (EC 3.2.1.20); alpha-galactosidase (EC 3.2.1.22); 6-phospho-beta-glucosidase (EC 3.2.1.86); alpha-glucuronidase (EC 3.2.1.139); alpha-galacturonase (EC 3.2.1.67); palatinase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Pectin Oligo Cleavage, Alpha-galactans Oligo Cleavage 0 0 -GH50 GH50 beta-agarase (EC 3.2.1.81). Glycoside Hydrolases carbon utilization CAZY 0 0 -GH51 GH51 endoglucanase (EC 3.2.1.4); endo-beta-1,4-xylanase (EC 3.2.1.8); beta-xylosidase (EC 3.2.1.37); alpha-L-arabinofuranosidase (EC 3.2.1.55); lichenase / endo-beta-1,3-1,4-glucanase (EC 3.2.1.73) Glycoside Hydrolases carbon utilization CAZY Arabinan Oligo Cleavage 0 0 -GH52 GH52 beta-xylosidase (EC 3.2.1.37). Glycoside Hydrolases carbon utilization CAZY Xylan Oligo Cleavage (Hemicellulose) 0 0 -GH53 GH53 endo-beta-1,4-galactanase (EC 3.2.1.89). Glycoside Hydrolases carbon utilization CAZY Beta-galactan (pectic galactan) Backbone Cleavage 0 0 -GH54 GH54 alpha-L-arabinofuranosidase (EC 3.2.1.55); beta-xylosidase (EC 3.2.1.37). Glycoside Hydrolases carbon utilization CAZY Arabinan Oligo Cleavage 0 0 -GH55 GH55 exo-beta-1,3-glucanase (EC 3.2.1.58); endo-beta-1,3-glucanase (EC 3.2.1.39) Glycoside Hydrolases carbon utilization CAZY Mixed-Linkage glucans Backbone Cleavage (Hemicellulose), Mixed-Linkage glucans Oligo Cleavage (Hemicellulose) 0 0 -GH56 GH56 hyaluronidase (EC 3.2.1.35); chondroitin hydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -GH57 GH57 alpha-amylase (EC 3.2.1.1); alpha-galactosidase (EC 3.2.1.22); amylopullulanase (EC 3.2.1.41); cyclomaltodextrinase (EC 3.2.1.54); branching enzyme (EC 2.4.1.18); 4-alpha-glucanotransferase (EC 2.4.1.25) Glycoside Hydrolases carbon utilization CAZY Starch Backbone Cleavage 0 0 -GH58 GH58 endo-N-acetylneuraminidase or endo-sialidase (EC 3.2.1.129) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH59 GH59 beta-galactosidase (EC 3.2.1.23); galactocerebrosidase (EC 3.2.1.46) Glycoside Hydrolases carbon utilization CAZY Beta-galactan (pectic galactan) Oligo Cleavage 0 0 -GH5 GH5 endo-beta-1,4-glucanase / cellulase (EC 3.2.1.4); endo-beta-1,4-xylanase (EC 3.2.1.8); beta-glucosidase (EC 3.2.1.21); beta-mannosidase (EC 3.2.1.25); beta-glucosylceramidase (EC 3.2.1.45); glucan beta-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-beta-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-beta-glucosidase (EC 3.2.1.75); mannan endo-beta-1,4-mannosidase (EC 3.2.1.78); cellulose beta-1,4-cellobiosidase (EC 3.2.1.91); steryl beta-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); beta-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-beta-1,4-glucanase (EC 3.2.1.151); endo-beta-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-alpha-L-rhamnosyl-beta-glucosidase (EC 3.2.1.168); beta-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-beta-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-); lichenase / endo-beta-1,3-1,4-glucanase (EC 3.2.1.73); beta-glycosidase (EC 3.2.1.-); endo-beta-1,3-glucanase / laminarinase (EC 3.2.1.39); beta-N-acetylhexosaminidase (EC 3.2.1.52); chitosanase (EC 3.2.1.132); beta-D-galactofuranosidase (EC 3.2.1.146); Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Backbone Cleavage, Amorphous Cellulose Oligo Cleavage, Xyloglucan Backbone Cleavage (Hemicellulose), Xylan Backbone Cleavage (Hemicellulose), Beta-mannan Backbone Cleavage (Hemicellulose), Mixed-Linkage glucans Backbone Cleavage (Hemicellulose), Chitin Oligo Cleavage 0 0 -GH60 GH60 Deleted family! Glycoside Hydrolases carbon utilization CAZY 0 0 -GH61 GH61 Copper-dependent lytic polysaccharide monooxygenases now reclassified in family AA9 Glycoside Hydrolases carbon utilization CAZY 0 0 -GH62 GH62 alpha-L-arabinofuranosidase (EC 3.2.1.55) Glycoside Hydrolases carbon utilization CAZY Arabinan Oligo Cleavage 0 0 -GH63 GH63 processing alpha-glucosidase (EC 3.2.1.106); alpha-1,3-glucosidase (EC 3.2.1.84); alpha-glucosidase (EC 3.2.1.20); mannosylglycerate alpha-mannosidase / mannosylglycerate hydrolase (EC 3.2.1.170); glucosylglycerate hydrolase (EC 3.2.1.208) Glycoside Hydrolases carbon utilization CAZY Alpha-mannan Oligo Cleavage (Hemicellulose) 0 0 -GH64 GH64 beta-1,3-glucanase (EC 3.2.1.39) Glycoside Hydrolases carbon utilization CAZY Mixed-Linkage glucans Backbone Cleavage (Hemicellulose) 0 0 -GH65 GH65 alpha,alpha-trehalase (EC 3.2.1.28); maltose phosphorylase (EC 2.4.1.8); trehalose phosphorylase (EC 2.4.1.64); kojibiose phosphorylase (EC 2.4.1.230); trehalose-6-phosphate phosphorylase (EC 2.4.1.216); nigerose phosphorylase (EC 2.4.1.279); 3-O-alpha-glucopyranosyl-L-rhamnose phosphorylase (EC 2.4.1.282); 2-O-alpha-glucopyranosylglycerol: phosphate beta-glucosyltransferase (EC 2.4.1.-); alpha-glucosyl-1,2-beta-galactosyl-L-hydroxylysine alpha-glucosidase (EC 3.2.1.107) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH66 GH66 cycloisomaltooligosaccharide glucanotransferase (EC 2.4.1.248); dextranase (EC 3.2.1.11). Glycoside Hydrolases carbon utilization CAZY 0 0 -GH67 GH67 alpha-glucuronidase (EC 3.2.1.139); xylan alpha-1,2-glucuronidase (EC 3.2.1.131) Glycoside Hydrolases carbon utilization CAZY Xylan Oligo Cleavage (Hemicellulose) 0 0 -GH68 GH68 levansucrase (EC 2.4.1.10); beta-fructofuranosidase (EC 3.2.1.26); inulosucrase (EC 2.4.1.9). Glycoside Hydrolases carbon utilization CAZY 0 0 -GH69 GH69 Deleted: now family PL16 Glycoside Hydrolases carbon utilization CAZY 0 0 -GH6 GH6 endoglucanase (EC 3.2.1.4); cellobiohydrolase (EC 3.2.1.91) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Backbone Cleavage 0 0 -GH70 GH70 dextransucrase (EC 2.4.1.5); alternansucrase (EC 2.4.1.140); reuteransucrase (EC 2.4.1.-); alpha-4,6-glucanotransferase (EC 2.4.1.-); alpha-1,2-branched dextransucrase (EC 2.4.1.-); alpha-4,3-glucanotransferase (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH71 GH71 alpha-1,3-glucanase (EC 3.2.1.59). Glycoside Hydrolases carbon utilization CAZY 0 0 -GH72 GH72 beta-1,3-glucanosyltransglycosylase (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH73 GH73 lysozyme (EC 3.2.1.17); mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase (EC 3.2.1.96); peptidoglycan hydrolase with endo-beta-N-acetylglucosaminidase specificity (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Chitin Backbone Cleavage 0 0 -GH74 GH74 endoglucanase (EC 3.2.1.4); oligoxyloglucan reducing end-specific cellobiohydrolase (EC 3.2.1.150); xyloglucanase (EC 3.2.1.151) Glycoside Hydrolases carbon utilization CAZY Xyloglucan Backbone Cleavage (Hemicellulose) 0 0 -GH75 GH75 chitosanase (EC 3.2.1.132) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH76 GH76 alpha-1,6-mannanase (EC 3.2.1.101); alpha-glucosidase (EC 3.2.1.20) Glycoside Hydrolases carbon utilization CAZY Alpha-mannan Backbone Cleavage (Hemicellulose), Alpha-mannan Oligo Cleavage (Hemicellulose) 0 0 -GH77 GH77 amylomaltase or 4-alpha-glucanotransferase (EC 2.4.1.25) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH78 GH78 alpha-L-rhamnosidase (EC 3.2.1.40); rhamnogalacturonan alpha-L-rhamnohydrolase (EC 3.2.1.174); L-Rhap-alpha-1,3-D-Apif -specific alpha-1,3-L-rhamnosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Pectin Oligo Cleavage, Rhamnose Oligo cleavage 0 0 -GH79 GH79 beta-glucuronidase (EC 3.2.1.31); hyaluronoglucuronidase (EC 3.2.1.36); heparanase (EC 3.2.1.166); baicalin beta-glucuronidase (EC 3.2.1.167); beta-4-O-methyl-glucuronidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -GH7 GH7 endo-beta-1,4-glucanase (EC 3.2.1.4); reducing end-acting cellobiohydrolase (EC 3.2.1.176); chitosanase (EC 3.2.1.132); endo-beta-1,3-1,4-glucanase (EC 3.2.1.73) Glycoside Hydrolases carbon utilization CAZY Crystalline Cellulose Backbone Cleavage, Amorphous Cellulose Backbone Cleavage, Mixed-Linkage glucans Backbone Cleavage (Hemicellulose) 0 0 -GH80 GH80 chitosanase (EC 3.2.1.132) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH81 GH81 endo-beta-1,3-glucanase (EC 3.2.1.39) Glycoside Hydrolases carbon utilization CAZY Mixed-Linkage glucans Backbone Cleavage (Hemicellulose) 0 0 -GH82 GH82 Iota;-carrageenase (EC 3.2.1.157) Glycoside Hydrolases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -GH83 GH83 neuraminidase (EC 3.2.1.18) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH84 GH84 N-acetyl beta-glucosaminidase (EC 3.2.1.52); hyaluronidase (EC 3.2.1.35); [protein]-3-O-(GlcNAc)-L-Ser/Thr beta-N-acetylglucosaminidase (EC 3.2.1.169) Glycoside Hydrolases carbon utilization CAZY Chitin Oligo Cleavage 0 0 -GH85 GH85 endo-beta-N-acetylglucosaminidase (EC 3.2.1.96) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH86 GH86 beta-agarase (EC 3.2.1.81); beta-porphyranase (EC 3.2.1.178) Glycoside Hydrolases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -GH87 GH87 mycodextranase (EC 3.2.1.61); alpha-1,3-glucanase (EC 3.2.1.59) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH88 GH88 d-4,5-unsaturated beta-glucuronyl hydrolase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Sulf-Polysachharides Oligo Cleavage 0 0 -GH89 GH89 alpha-N-acetylglucosaminidase (EC 3.2.1.50) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH8 GH8 chitosanase (EC 3.2.1.132); cellulase (EC 3.2.1.4); licheninase (EC 3.2.1.73); endo-1,4-beta-xylanase (EC 3.2.1.8); reducing-end-xylose releasing exo-oligoxylanase (EC 3.2.1.156) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Backbone Cleavage, Xylan Backbone Cleavage (Hemicellulose), Mixed-Linkage glucans Backbone Cleavage (Hemicellulose) 0 0 -GH90 GH90 endorhamnosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH91 GH91 inulin lyase [DFA-I-forming] (EC 4.2.2.17); inulin lyase [DFA-III-forming] (EC 4.2.2.18); difructofuranose 1,2':2,3' dianhydride hydrolase [DFA-IIIase] (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH92 GH92 mannosyl-oligosaccharide alpha-1,2-mannosidase (EC 3.2.1.113); mannosyl-oligosaccharide alpha-1,3-mannosidase (EC 3.2.1.-); mannosyl-oligosaccharide alpha-1,6-mannosidase (EC 3.2.1.-); alpha-mannosidase (EC 3.2.1.24); alpha-1,2-mannosidase (EC 3.2.1.-); alpha-1,3-mannosidase (EC 3.2.1.-); alpha-1,4-mannosidase (EC 3.2.1.-); mannosyl-1-phosphodiester alpha-1,P-mannosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Alpha-mannan Oligo Cleavage (Hemicellulose) 0 0 -GH93 GH93 exo-alpha-L-1,5-arabinanase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Arabinan Oligo Cleavage 0 0 -GH94 GH94 cellobiose phosphorylase (EC 2.4.1.20); laminaribiose phosphorylase (EC 2.4.1.31); cellodextrin phosphorylase (EC 2.4.1.49); chitobiose phosphorylase (EC 2.4.1.-); cyclic beta-1,2-glucan synthase (EC 2.4.1.-); cellobionic acid phosphorylase (EC 2.4.1.321); beta-1,2-oligoglucan phosphorylase (EC 2.4.1.-) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Oligo Cleavage 0 0 -GH95 GH95 alpha-L-fucosidase (EC 3.2.1.51); alpha-1,2-L-fucosidase (EC 3.2.1.63); alpha-L-galactosidase (EC 3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Fucose Oligo Cleavage 0 0 -GH96 GH96 alpha-agarase (EC 3.2.1.158) Glycoside Hydrolases carbon utilization CAZY 0 0 -GH97 GH97 glucoamylase (EC 3.2.1.3); alpha-glucosidase (EC 3.2.1.20); alpha-galactosidase (EC 3.2.1.22) Glycoside Hydrolases carbon utilization CAZY Starch Oligo Cleavage, Alpha-galactans Oligo Cleavage 0 0 -GH98 GH98 blood-group endo-beta-1,4-galactosidase (EC 3.2.1.102); blood group A- and B-cleaving endo-beta-1,4-galactosidase (EC 3.2.1.-); endo-beta-1,4-xylanase (EC 3.2.1.8); endo-beta-1,4-xylanase (EC 3.2.1.8) Glycoside Hydrolases carbon utilization CAZY Xylan Backbone Cleavage (Hemicellulose) 0 0 -GH99 GH99 glycoprotein endo-alpha-1,2-mannosidase (EC 3.2.1.130); mannan endo-1,2-alpha-mannanase (3.2.1.-) Glycoside Hydrolases carbon utilization CAZY Alpha-mannan Backbone Cleavage (Hemicellulose) 0 0 -GH9 GH9 endoglucanase (EC 3.2.1.4); endo-beta-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6); beta-glucosidase (EC 3.2.1.21); lichenase / endo-beta-1,3-1,4-glucanase (EC 3.2.1.73); exo-beta-1,4-glucanase / cellodextrinase (EC 3.2.1.74); cellobiohydrolase (EC 3.2.1.91); xyloglucan-specific endo-beta-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151); exo-beta-glucosaminidase (EC 3.2.1.165) Glycoside Hydrolases carbon utilization CAZY Amorphous Cellulose Backbone Cleavage, Amorphous Cellulose Oligo Cleavage, Xyloglucan Backbone Cleavage (Hemicellulose), Mixed-Linkage glucans Backbone Cleavage (Hemicellulose) 0 0 -GT0 GT0 Glycosyltransferases not yet assigned to a family GlycosylTransferases carbon utilization CAZY 0 0 -GT100 GT100 alpha-sialyltransferase (EC 2.4.99.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT101 GT101 glucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT102 GT102 dTDP-beta-L-Rhap : O-antigen-polysaccharide alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.289) GlycosylTransferases carbon utilization CAZY 0 0 -GT103 GT103 UDP-GlcpNAc: O-antigen-polysaccharide beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.56) GlycosylTransferases carbon utilization CAZY 0 0 -GT104 GT104 dTDP-beta-L-Rhap : arginine alpha-L-rhamnosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT105 GT105 Dol-P-Man: protein alpha-mannosyltransferase (EC 2.4.1.109); Dol-P-Man:protein mannosyltransferase (EC 2.4.1.109) GlycosylTransferases carbon utilization CAZY 0 0 -GT106 GT106 UDP-beta-L-rhamnose:rhamnogalacturonan I 4-alpha-rhamnosyltransferase (EC 2.4.1.351) GlycosylTransferases carbon utilization CAZY 0 0 -GT107 GT107 CMP-beta-KDO: beta-2,4-KDO transferase (EC 2.4.99.-); CMP-beta-KDO: beta-2,7-KDO transferase (EC 2.4.99.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT10 GT10 galactoside alpha-1,3/1,4-L-fucosyltransferase (EC 2.4.1.65); galactoside alpha-1,3-L-fucosyltransferase (EC 2.4.1.152); glycoprotein alpha-1,3-L-fucosyltransferase (EC 2.4.1.214) GlycosylTransferases carbon utilization CAZY 0 0 -GT11 GT11 GDP-L-Fuc: galactoside alpha-1,2-L-fucosyltransferase (EC 2.4.1.69); GDP-L-Fuc: beta-LacNac alpha-1,3-L-fucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT12 GT12 [N-acetylneuraminyl]-galactosylglucosylceramide N-acetylgalactosaminyltransferase (EC 2.4.1.92). GlycosylTransferases carbon utilization CAZY 0 0 -GT13 GT13 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC 2.4.1.101) GlycosylTransferases carbon utilization CAZY 0 0 -GT14 GT14 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102); N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.150); protein O-beta-xylosyltransferase (EC 2.4.2.26); UDP-GlcA:arabinogalactan beta-glucuronosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT15 GT15 glycolipid 2-alpha-mannosyltransferase (EC 2.4.1.131); GDP-Man: alpha-1,2-mannosyltransferase (EC 2.4.1.-). GlycosylTransferases carbon utilization CAZY 0 0 -GT16 GT16 alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC 2.4.1.143). GlycosylTransferases carbon utilization CAZY 0 0 -GT17 GT17 beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.144). GlycosylTransferases carbon utilization CAZY 0 0 -GT18 GT18 alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase (EC 2.4.1.155). GlycosylTransferases carbon utilization CAZY 0 0 -GT19 GT19 lipid-A-disaccharide synthase (EC 2.4.1.182). GlycosylTransferases carbon utilization CAZY 0 0 -GT1 GT1 UDP-glucuronosyltransferase (EC 2.4.1.17); zeatin O-beta-xylosyltransferase (EC 2.4.2.40); 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.45); N-acylsphingosine galactosyltransferase (EC 2.4.1.47); flavonol 3-O-glucosyltransferase (EC 2.4.1.91); anthocyanidin 3-O-glucosyltransferase (EC 2.4.1.115); sinapate 1-glucosyltransferase (EC 2.4.1.120); indole-3-acetate beta-glucosyltransferase (EC 2.4.1.121); flavonol L-rhamnosyltransferase (EC 2.4.1.159); sterol glucosyltransferase (EC 2.4.1.173); UDP-Glc: 4-hydroxybenzoate 4-O-beta-glucosyltransferase (EC 2.4.1.194); zeatin O-beta-glucosyltransferase (EC 2.4.1.203); limonoid glucosyltransferase (EC 2.4.1.210); UDP-GlcA: baicalein 7-O-beta-glucuronosyltransferase (EC 2.4.1.253); UDP-Glc: chalcone 4′-O-beta-glucosyltransferase (EC 2.4.1.286); ecdysteroid UDP-glucosyltransferase (EC 2.4.1.-); salicylic acid beta-glucosyltransferase (EC 2.4.1.-); anthocyanin 3-O-galactosyltransferase (EC 2.4.1.-); anthocyanin 5-O-glucosyltransferase (EC 2.4.1.-); dTDP-beta-2-deoxy-L-fucose: alpha-L-2-deoxyfucosyltransferase (EC 2.4.1.-); UDP-beta-L-rhamnose: alpha-L-rhamnosyltransferase (EC 2.4.1.-); zeaxanthin glucosyltransferase (EC 2.4.1.-); flavone 8-C-glycosyltransferase GlycosylTransferases carbon utilization CAZY 0 0 -GT20 GT20 alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC 2.4.1.15); Glucosylglycerol-phosphate synthase (EC 2.4.1.213); trehalose-6-P phosphatase (EC 3.1.3.12); [retaining] GDP-valeniol: validamine 7-phosphate valeniolyltransferase (EC 2.-.-.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT21 GT21 UDP-Glc: ceramide beta-glucosyltransferase (EC 2.4.1.80). GlycosylTransferases carbon utilization CAZY 0 0 -GT22 GT22 Dol-P-Man: Man6GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.259); Dol-P-Man: Man8GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase (EC 2.4.1.261); Dol-P-Man: Man2-GlcNAc-phosphatidylinositol alpha-1,2-mannosyltransferase (EC 2.4.1.-); Dol-P-Man: Man3-GlcNAc-phosphatidylinositol alpha-1,2-mannosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT23 GT23 N-acetyl-beta-D-glucosaminide alpha-1,6-L-fucosyltransferase (EC 2.4.1.68); chitin-oligosaccharide alpha-1,6-L-fucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT24 GT24 UDP-Glc: glycoprotein alpha-glucosyltransferase (EC 2.4.1.-). GlycosylTransferases carbon utilization CAZY 0 0 -GT25 GT25 lipopolysaccharide beta-1,4-galactosyltransferase (EC 2.4.1.-); beta-1,3-glucosyltransferase (EC 2.4.1.-); beta-1,2-glucosyltransferase (EC 2.4.1.-); beta-1,2-galactosyltransferase (EC 2.4.1.-); LPS beta-1,4-galactosyltransferase (EC 2.4.1.-); occidiofungin beta-xylosyltransferase (EC 2.4.2.-); UDP-Gal:procollagen beta-galactosyltransferase (EC 2.4.1.50) GlycosylTransferases carbon utilization CAZY 0 0 -GT26 GT26 UDP-ManNAcA: beta-N-acetyl mannosaminuronyltransferase (EC 2.4.1.-); UDP-ManNAc: beta-N-acetyl-mannosaminyltransferase (EC 2.4.1.-); UDP-Glc: beta-1,4-glucosyltransferase (EC 2.4.1.-); beta-1,4-galactosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT27 GT27 polypeptide alpha-N-acetylgalactosaminyltransferase (EC 2.4.1.41) GlycosylTransferases carbon utilization CAZY 0 0 -GT28 GT28 1,2-diacylglycerol 3-beta-galactosyltransferase (EC 2.4.1.46); 1,2-diacylglycerol 3-beta-glucosyltransferase (EC 2.4.1.157); UDP-GlcNAc: Und-PP-MurAc-pentapeptide beta-N-acetylglucosaminyltransferase (EC 2.4.1.227); digalactosyldiacylglycerol synthase (EC 2.4.1.241) GlycosylTransferases carbon utilization CAZY 0 0 -GT29 GT29 sialyltransferase (EC 2.4.99.-); beta-galactoside alpha-2,6-sialyltransferase (EC 2.4.99.1); alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.99.3); beta-galactoside alpha-2,3-sialyltransferase (EC 2.4.99.4); N-acetyllactosaminide alpha-2,3-sialyltransferase (EC 2.4.99.6); (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.99.7); alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (EC 2.4.99.8); lactosylceramide alpha-2,3-sialyltransferase (EC 2.4.99.9) GlycosylTransferases carbon utilization CAZY 0 0 -GT2 GT2 cellulose synthase (EC 2.4.1.12); chitin synthase (EC 2.4.1.16); dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83); dolichyl-phosphate beta-glucosyltransferase (EC 2.4.1.117); N-acetylglucosaminyltransferase (EC 2.4.1.-); N-acetylgalactosaminyltransferase (EC 2.4.1.-); hyaluronan synthase (EC 2.4.1.212); chitin oligosaccharide synthase (EC 2.4.1.-); beta-1,3-glucan synthase (EC 2.4.1.34); beta-1,4-mannan synthase (EC 2.4.1.-); beta-mannosylphosphodecaprenol-mannooligosaccharide alpha-1,6-mannosyltransferase (EC 2.4.1.199); UDP-Galf: rhamnopyranosyl-N-acetylglucosaminyl-PP-decaprenol beta-1,4/1,5-galactofuranosyltransferase (EC 2.4.1.287); UDP-Galf: galactofuranosyl-galactofuranosyl-rhamnosyl-N-acetylglucosaminyl-PP-decaprenol beta-1,5/1,6-galactofuranosyltransferase (EC 2.4.1.288); dTDP-L-Rha: N-acetylglucosaminyl-PP-decaprenol alpha-1,3-L-rhamnosyltransferase (EC 2.4.1.289) GlycosylTransferases carbon utilization CAZY 0 0 -GT30 GT30 CMP-beta-KDO: alpha-3-deoxy-D-manno-octulosonic-acid (KDO) transferase (EC 2.4.99.-). GlycosylTransferases carbon utilization CAZY 0 0 -GT31 GT31 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.149); Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (EC 2.4.1.122); fucose-specific beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-); globotriosylceramide beta-1,3-GalNAc transferase (EC 2.4.1.79); chondroitin synthase (beta-1,3-GlcUA and beta-1,4-GalNAc transferase (EC 2.4.1.175); chondroitin beta-1,3-glucuronyltransferase (EC 2.4.1.226); chondroitin beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.-); UDP-Gal: beta-galactosylxylosylprotein beta-1,3-galactosyltransferase (EC 2.4.1.134); UDP-GlcNAc: O-fucosylpeptide beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.222) GlycosylTransferases carbon utilization CAZY 0 0 -GT32 GT32 alpha-1,6-mannosyltransferase (EC 2.4.1.-); alpha-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.-); alpha-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.-); GDP-Man: inositol-phosphorylceramide transferase (EC 2.4.1.-); UDP-Gal: beta-galactoside alpha-1,4-galactosyltransferase (EC 2.4.1.-); UDP-Gal: lactose/N-acetyl-lactosamine alpha-1,4-galactosyltransferase (EC 2.4.1.-); UDP-Glc: protein alpha-glucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT33 GT33 GDP-Man: chitobiosyldiphosphodolichol beta-mannosyltransferase (EC 2.4.1.142). GlycosylTransferases carbon utilization CAZY 0 0 -GT34 GT34 UDP-Gal: galactomannan alpha-1,6-galactosyltransferase (EC 2.4.1.-); UDP-Xyl: xyloglucan alpha-1,6-xylosyltransferase (EC 2.4.2.39); alpha-1,2-galactosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT35 GT35 glycogen or starch phosphorylase (EC 2.4.1.1). GlycosylTransferases carbon utilization CAZY 0 0 -GT36 GT36 Deleted: now family GH94 GlycosylTransferases carbon utilization CAZY 0 0 -GT37 GT37 galactoside 2-L-fucosyltransferase (EC 2.4.1.69) GlycosylTransferases carbon utilization CAZY 0 0 -GT38 GT38 polysialyltransferase (EC 2.4.-.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT39 GT39 Dol-P-Man: protein alpha-mannosyltransferase (EC 2.4.1.109) GlycosylTransferases carbon utilization CAZY 0 0 -GT3 GT3 glycogen synthase (EC 2.4.1.11). GlycosylTransferases carbon utilization CAZY 0 0 -GT40 GT40 beta-1,3-galactofuranosyltransferases (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT41 GT41 UDP-GlcNAc: peptide beta-N-acetylglucosaminyltransferase (EC 2.4.1.255); UDP-Glc: peptide N-beta-glucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT42 GT42 CMP-NeuAc alpha-2,3-sialyltransferase (EC 2.4.99.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT43 GT43 beta-glucuronyltransferase (EC 2.4.1.135); UDP-Xyl: xylan beta-1,4-xylosyltransferase (EC 2.4.2.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT44 GT44 UDP-Glc: alpha-glucosyltransferase (EC 2.4.1.-); UDP-GlcNAc: alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-). GlycosylTransferases carbon utilization CAZY 0 0 -GT45 GT45 alpha-N-acteylglucosaminyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT46 GT46 Deleted GlycosylTransferases carbon utilization CAZY 0 0 -GT47 GT47 heparan beta-glucuronyltransferase (EC 2.4.1.225); xyloglucan beta-galactosyltransferase (EC 2.4.1.-); heparan synthase (EC 2.4.1.-); arabinan alpha-L-arabinosyltransferase (EC 2.4.2.-). GlycosylTransferases carbon utilization CAZY 0 0 -GT48 GT48 1,3-beta-glucan synthase (EC 2.4.1.34) GlycosylTransferases carbon utilization CAZY 0 0 -GT49 GT49 beta-1,3-N-acetylglucosaminyltransferase (EC 2.4.1.-). GlycosylTransferases carbon utilization CAZY 0 0 -GT4 GT4 sucrose synthase (EC 2.4.1.13); sucrose-phosphate synthase (EC 2.4.1.14); alpha-glucosyltransferase (EC 2.4.1.52); lipopolysaccharide N-acetylglucosaminyltransferase (EC 2.4.1.56); phosphatidylinositol alpha-mannosyltransferase (EC 2.4.1.57); GDP-Man: Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase (EC 2.4.1.132); GDP-Man: Man3GlcNAc2-PP-dolichol/Man4GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase (EC 2.4.1.131); digalactosyldiacylglycerol synthase (EC 2.4.1.141); 1,2-diacylglycerol 3-glucosyltransferase (EC 2.4.1.157); diglucosyl diacylglycerol synthase (EC 2.4.1.208); trehalose phosphorylase (EC 2.4.1.231); NDP-Glc: alpha-glucose alpha-glucosyltransferase / alpha,alpha-trehalose synthase (EC 2.4.1.245); GDP-Man: Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase (EC 2.4.1.257); UDP-GlcNAc: 2-deoxystreptamine alpha-N-acetylglucosaminyltransferase (EC 2.4.1.283); UDP-GlcNAc: ribostamycin alpha-N-acetylglucosaminyltransferase (EC 2.4.1.285); UDP-Gal alpha-galactosyltransferase (EC 2.4.1.-); UDP-Xyl alpha-xylosyltransferase (EC 2.4.2.-); UDP-GlcA alpha-glucuronyltransferase (EC 2.4.1.-); UDP-Glc alpha-glucosyltransferase (EC 2.4.1.-); UDP-GalNAc: GalNAc-PP-Und alpha-1,3-N-acetylgalactosaminyltransferase (EC 2.4.1.306); UDP-GalNAc: N,N'-diacetylbacillosaminyl-PP-Und alpha-1,3-N-acetylgalactosaminyltransferase (EC 2.4.1.290); ADP-dependent alpha-maltose-1-phosphate synthase (2.4.1.342) GlycosylTransferases carbon utilization CAZY 0 0 -GT50 GT50 Dol-P-Man alpha-1,4-mannosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT51 GT51 murein polymerase (EC 2.4.1.129). GlycosylTransferases carbon utilization CAZY 0 0 -GT52 GT52 alpha-2,3-sialyltransferase (EC 2.4.99.4); alpha-glucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT53 GT53 UDP-L-Ara: alpha-L-arabinosyltransferase (EC 2.4.2.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT54 GT54 UDP-GlcNAc: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.145) GlycosylTransferases carbon utilization CAZY 0 0 -GT55 GT55 GDP-Man: mannosyl-3-phosphoglycerate synthase (EC 2.4.1.217) GlycosylTransferases carbon utilization CAZY 0 0 -GT56 GT56 TDP-Fuc4NAc: lipid II Fuc4NAc transferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT57 GT57 Dol-P-Glc: alpha-1,3-glucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT58 GT58 Dol-P-Man: Man5GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase (EC 2.4.1.258) GlycosylTransferases carbon utilization CAZY 0 0 -GT59 GT59 Dol-P-Glc: Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase (EC 2.4.1.256) GlycosylTransferases carbon utilization CAZY 0 0 -GT5 GT5 UDP-Glc: glycogen glucosyltransferase (EC 2.4.1.11); ADP-Glc: starch glucosyltransferase (EC 2.4.1.21); NDP-Glc: starch glucosyltransferase (EC 2.4.1.242); UDP-Glc: alpha-1,3-glucan synthase (EC 2.4.1.183) UDP-Glc: alpha-1,4-glucan synthase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT60 GT60 UDP-GlcNAc: polypeptide alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-); UDP-GlcNAc: hydroxyproline polypeptide alpha-N-acetylglucosaminyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT61 GT61 beta-1,2-xylosyltransferase (EC 2.4.2.38) ; protein O-beta-N-acetylglucosaminyltransferase (EC 2.4.1.94) ; xylan alpha-1,3-arabinofuranosyltransferase (EC 2.4.2.-) ; GlycosylTransferases carbon utilization CAZY 0 0 -GT62 GT62 alpha-1,2-mannosyltransferase (EC 2.4.1.-); alpha-1,6-mannosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT63 GT63 UDP-Glc: DNA beta-glucosyltransferase (EC 2.4.1.27) GlycosylTransferases carbon utilization CAZY 0 0 -GT64 GT64 UDP-GlcNAc: heparan alpha-N-acetylhexosaminyltransferase (EC 2.4.1.224) GlycosylTransferases carbon utilization CAZY 0 0 -GT65 GT65 GDP-Fuc: protein O-alpha-fucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT66 GT66 dolichyl-diphosphooligosaccharide—protein glycotransferase (EC 2.4.99.18); undecaprenyl-diphosphooligosaccharide—protein glycotransferase (EC 2.4.99.19) GlycosylTransferases carbon utilization CAZY 0 0 -GT67 GT67 UDP-Gal: phosphoglycan beta-1,3-galactosyltransferase 1 (SCG1) (EC 2.4.1.-); UDP-GlcNAc beta-1,2-N-acetylglucosaminyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT68 GT68 GDP-Fuc: protein O-alpha-fucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT69 GT69 GDP-Man: alpha-1,3-mannosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT6 GT6 alpha-1,3-galactosyltransferase (EC 2.4.1.87); alpha-1,3 N-acetylgalactosaminyltransferase (EC 2.4.1.40); alpha-galactosyltransferase (EC 2.4.1.37); globoside alpha-N-acetylgalactosaminyltransferase (EC 2.4.1.88). GlycosylTransferases carbon utilization CAZY 0 0 -GT70 GT70 UDP-GlcA: beta-glucuronosyltransferase (EC 2.4.1.17) GlycosylTransferases carbon utilization CAZY 0 0 -GT71 GT71 alpha-mannosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT72 GT72 UDP-Glc: DNA alpha-glucosyltransferase (EC 2.4.1.26) GlycosylTransferases carbon utilization CAZY 0 0 -GT73 GT73 CMP-beta-KDO: alpha-3-deoxy-D-manno-octulosonic-acid (KDO) transferase (EC 2.4.99.-). GlycosylTransferases carbon utilization CAZY 0 0 -GT74 GT74 alpha-1,2-L-fucosyltransferase (EC 2.4.1.69) GlycosylTransferases carbon utilization CAZY 0 0 -GT75 GT75 UDP-Glc: self-glucosylating beta-glucosyltransferase (EC 2.4.1.-); UDP-L-arabinopyranose mutase (EC 5.4.99.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT76 GT76 Dol-P-Man: alpha-1,6-mannosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT77 GT77 alpha-xylosyltransferase (EC 2.4.2.39); alpha-1,3-galactosyltransferase (EC 2.4.1.37); arabinosyltransferase (EC 2.4.2.-); arabinosyltransferase (EC 2.4.2.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT78 GT78 GDP-Man: alpha-mannosyltransferase (mannosylglycerate synthase) (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT79 GT79 GDP-D-Ara: phosphoglycan alpha-1,2-D-arabinopyranosyltransferase 1 (EC 2.4.2.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT7 GT7 lactose synthase (EC 2.4.1.22); beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase (EC 2.4.1.38); N-acetyllactosamine synthase (EC 2.4.1.90); xylosylprotein beta-4-galactosyltransferase (EC 2.4.1.133); UDP-Gal: neolactotriaosylceramide beta-1,4-galactosyltransferase (EC 2.4.1.275); beta-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT80 GT80 beta-galactoside alpha-2,6-sialyltransferase (EC 2.4.99.1); beta-galactoside alpha-2,3-sialyltransferase (EC 2.4.99.4) GlycosylTransferases carbon utilization CAZY 0 0 -GT81 GT81 NDP-Glc: glucosyl-3-phosphoglycerate synthase (EC 2.4.1.-); NDP-Man: mannosyl-3-phosphoglycerate synthase (EC 2.4.1.-); GlycosylTransferases carbon utilization CAZY 0 0 -GT82 GT82 UDP-GalNAc: beta-1,4-N-acetylgalactosaminyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT83 GT83 undecaprenyl phosphate-alpha-L-Ara4N: 4-amino-4-deoxy-beta-L-arabinosyltransferase (EC 2.4.2.43); dodecaprenyl phosphate-beta-galacturonic acid: lipopolysaccharide core alpha-galacturonosyl transferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT84 GT84 cyclic beta-1,2-glucan synthase (EC 2.4.1.-); GlycosylTransferases carbon utilization CAZY 0 0 -GT85 GT85 beta-D-arabinofuranosyl monophosphoryldecaprenol: galactan alpha-D-arabinofuranosyltransferase (EC 2.4.2.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT86 GT86 Deleted. GlycosylTransferases carbon utilization CAZY 0 0 -GT87 GT87 polyprenol-P-Man: alpha-1,2-mannosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT88 GT88 UDP-Glc: alpha-glucosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT89 GT89 beta-D-arabinofuranosyl-1-monophosphoryldecaprenol : arabinan beta-1,2-arabinofuranosyltransferase (EC 2.4.2.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT8 GT8 lipopolysaccharide alpha-1,3-galactosyltransferase (EC 2.4.1.44); UDP-Glc: (glucosyl)lipopolysaccharide alpha-1,2-glucosyltransferase (EC 2.4.1.-); lipopolysaccharide glucosyltransferase 1 (EC 2.4.1.58); glycogenin glucosyltransferase (EC 2.4.1.186); inositol 1-alpha-galactosyltransferase (galactinol synthase) (EC 2.4.1.123); homogalacturonan alpha-1,4-galacturonosyltransferase (EC 2.4.1.43); UDP-GlcA: xylan alpha-glucuronyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT90 GT90 UDP-Xyl: (mannosyl) glucuronoxylomannan/galactoxylomannan beta-1,2-xylosyltransferase (EC 2.4.2.-); UDP-Glc: protein O-beta-glucosyltransferase (EC 2.4.1.-); UDP-Xyl: protein O-beta-xylosyltransferase (EC 2.4.2.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT91 GT91 beta-1,2-mannosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT92 GT92 UDP-Gal: N-glycan core alpha-1,6-fucoside beta-1,4-galactosyltransferase (EC 2.4.1.-); UDP-Gal: beta-galactoside beta-1,4-galactosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT93 GT93 UDP-GluA : alpha-glucuronyltransferase (EC 2.4.1.-) involved in GAG polymerization GlycosylTransferases carbon utilization CAZY 0 0 -GT94 GT94 GDP-Man: GlcA-beta-1,2-Man-alpha-1,3-Glc-beta-1,4-Glc-alpha-1-PP-undecaprenol beta-1,4-mannosyltransferase (2.4.1.251) GlycosylTransferases carbon utilization CAZY 0 0 -GT95 GT95 UDP-beta-L-Araf:hydroxyproline beta-L-arabinofuranosyltransferase (EC 2.4.2.-); GlycosylTransferases carbon utilization CAZY 0 0 -GT96 GT96 UDP-Gal: peptidyl serine alpha-galactosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT97 GT97 CMP-Neu5Ac:alpha-galactoside alpha-2,6-sialyltransferase (EC 2.4.99.-); CMP-Neu5Ac:alpha-glucoside alpha-2,6-sialyltransferase (EC 2.4.99.-); GlycosylTransferases carbon utilization CAZY 0 0 -GT98 GT98 Dol-P-Man : protein [tryptophan] alpha-C-mannosyltransferase (EC 2.4.1.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT99 GT99 CMP-beta-KDO 3-deoxy-beta-D-manno-oct-2-ulosonic acid transferase (EC 2.4.99.-) GlycosylTransferases carbon utilization CAZY 0 0 -GT9 GT9 lipopolysaccharide N-acetylglucosaminyltransferase (EC 2.4.1.56); heptosyltransferase (EC 2.4.-.-). GlycosylTransferases carbon utilization CAZY 0 0 -PL0 PL0 Polysaccharide lyases not yet assigned to a family. Polysaccharide Lyases carbon utilization CAZY 0 0 -PL10 PL10 pectate lyase (EC 4.2.2.2) Polysaccharide Lyases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -PL11 PL11 rhamnogalacturonan endolyase (EC 4.2.2.23); rhamnogalacturonan exolyase (EC 4.2.2.24) Polysaccharide Lyases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -PL12 PL12 heparin-sulfate lyase (EC 4.2.2.8) Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -PL13 PL13 heparin lyase (EC 4.2.2.7) Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -PL14 PL14 alginate lyase (EC 4.2.2.3); exo-oligoalginate lyase (EC 4.2.2.26); beta-1,4-glucuronan lyase (EC 4.2.2.14) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL15 PL15 oligo-alginate lyase (EC 4.2.2.-); alginate lyase (EC 4.2.2.3) Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage, Sulf-Polysachharides Oligo Cleavage 0 0 -PL16 PL16 hyaluronan lyase (EC 4.2.2.1). Polysaccharide Lyases carbon utilization CAZY 0 0 -PL17 PL17 alginate lyase (EC 4.2.2.3); oligoalginate lyase (EC 4.2.2.26) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL18 PL18 alginate lyase (EC 4.2.2.3); poly(alpha-L-guluronate) lyase / G-specific alginate lyase (EC 4.2.2.11); MG-specific alginate lyase (EC 4.2.2.-) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL19 PL19 Deleted: now family GH91 Polysaccharide Lyases carbon utilization CAZY 0 0 -PL1 PL1 pectate lyase (EC 4.2.2.2); exo-pectate lyase (EC 4.2.2.9); pectin lyase (EC 4.2.2.10). Polysaccharide Lyases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -PL20 PL20 endo-beta-1,4-glucuronan lyase (EC 4.2.2.14) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL21 PL21 heparin lyase (EC 4.2.2.7); heparin-sulfate lyase (EC 4.2.2.8); acharan-sulfate lyase (EC 4.2.2.-) Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage, Sulf-Polysachharides Oligo Cleavage 0 0 -PL22 PL22 oligogalacturonate lyase / oligogalacturonide lyase (EC 4.2.2.6) Polysaccharide Lyases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -PL23 PL23 chondroitin lyase (EC 4.2.2.-); Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Oligo Cleavage 0 0 -PL24 PL24 ulvan lyase (EC 4.2.2.-). Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Oligo Cleavage, Rhamnose Oligo cleavage 0 0 -PL25 PL25 ulvan lyase (EC 4.2.2.-). Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Oligo Cleavage, Rhamnose Oligo cleavage 0 0 -PL26 PL26 rhamnogalacturonan exolyase (EC 4.2.2.24). Polysaccharide Lyases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -PL27 PL27 L-rhamnose-alpha-1,4-D-glucuronate lyase (EC 4.2.2.-) Polysaccharide Lyases carbon utilization CAZY Rhamnose Oligo cleavage 0 0 -PL28 PL28 ulvan lyase (EC 4.2.2.-) Polysaccharide Lyases carbon utilization CAZY Rhamnose Oligo cleavage 0 0 -PL29 PL29 hyaluronate lyase (EC 4.2.2.1); chondroitin-sulfate ABC endolyase (EC 4.2.2.20); dermatan sulfate lyase (4.2.2.-); dermatan sulfate lyase (EC 4.2.2.-) Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -PL2 PL2 pectate lyase (EC 4.2.2.2); exo-polygalacturonate lyase (EC 4.2.2.9). Polysaccharide Lyases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -PL30 PL30 hyaluronate lyase (EC 4.2.2.1) Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -PL31 PL31 endo-beta-1,4-glucuronan lyase (EC 4.2.2.14) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL32 PL32 poly(beta-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL33 PL33 hyaluronate lyase (EC 4.2.2.1); gellan lyase (EC 4.2.2.25); chondroitin sulfate lyase (EC 4.2.2.20) Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -PL34 PL34 alginate lyase (EC 4.2.2.-) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL35 PL35 chondroitin lyase / chondroitinase (EC 4.2.2.-); chondroitin AC lyase (EC 4.2.2.5) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL36 PL36 poly(beta-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL37 PL37 chondroitin-sulfate ABC endolyase (EC 4.2.2.20); heparin-sulfate lyase / heparin lyase III (EC 4.2.2.8); ulvan lyase (EC 4.2.2.-) Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -PL3 PL3 pectate lyase (EC 4.2.2.2). Polysaccharide Lyases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -PL4 PL4 rhamnogalacturonan endolyase (EC 4.2.2.23). Polysaccharide Lyases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -PL5 PL5 alginate lyase (EC 4.2.2.3). Polysaccharide Lyases carbon utilization CAZY 0 0 -PL6 PL6 alginate lyase (EC 4.2.2.3); chondroitinase B (EC 4.2.2.19); MG-specific alginate lyase (EC 4.2.2.-); poly(alpha-L-guluronate) lyase / G-specific alginate lyase (EC 4.2.2.11); Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage, Sulf-Polysachharides Oligo Cleavage 0 0 -PL7 PL7 poly(beta-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3); alpha-L-guluronate lyase / G-specific alginate lyase (EC 4.2.2.11); poly-(MG)-lyase / MG-specific alginate lyase (EC 4.2.2.-); endo-beta-1,4-glucuronan lyase (EC 4.2.2.14) Polysaccharide Lyases carbon utilization CAZY 0 0 -PL8 PL8 hyaluronate lyase (EC 4.2.2.1); chondroitin AC lyase (EC 4.2.2.5); xanthan lyase (EC 4.2.2.12); chondroitin ABC lyase (EC 4.2.2.20) Polysaccharide Lyases carbon utilization CAZY Sulf-Polysachharides Backbone Cleavage 0 0 -PL9 PL9 pectate lyase (EC 4.2.2.2); exopolygalacturonate lyase (EC 4.2.2.9); thiopeptidoglycan lyase (EC 4.2.2.-). Polysaccharide Lyases carbon utilization CAZY Pectin Backbone Cleavage 0 0 -K05810 polyphenol oxidase polyphenols carbon utilization Polyphenolics Cleavage 0 0 -K00422 polyphenol oxidase polyphenols carbon utilization Polyphenolics Cleavage 0 0 -K05909 polyphenol oxidase polyphenols carbon utilization Polyphenolics Cleavage 0 0 -K01812 glucuronate isomerase Pentose and glucuronate interconversions carbon utilization sugar utilization galacturonic acid degradation 0 0 -K00041 tagaturonate reductase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization galacturonic acid degradation 0 0 -K01685 altronate hydrolase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization galacturonic acid degradation 0 0 -K16849 altronate dehydratase small subunit Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization galacturonic acid degradation 0 0 -K16850 altronate dehydratase large subunit Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization galacturonic acid degradation 0 0 -K00874 2-dehydro-3-deoxygluconokinase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization galacturonic acid degradation 0 0 -K01625 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization galacturonic acid degradation 0 0 -K01785 aldose 1-epimerase Galactose metabolism carbon utilization (Woodcroft) sugar utilization galactose degradation 0 0 -K00849 galactokinase Galactose metabolism carbon utilization (Woodcroft) sugar utilization galactose degradation 0 0 -K00965 UDPglucose--hexose-1-phosphate uridylyltransferase Galactose metabolism carbon utilization (Woodcroft) sugar utilization galactose degradation 0 0 -K01784 UDP-glucose 4-epimerase Galactose metabolism carbon utilization (Woodcroft) sugar utilization galactose degradation 0 0 -K01190 beta-galactosidase Galactose metabolism carbon utilization (Woodcroft) sugar utilization lactose degradation 0 0 -K12111 evolved beta-galactosidase subunit alpha Galactose metabolism carbon utilization (Woodcroft) sugar utilization lactose degradation 0 0 -K12112 evolved beta-galactosidase subunit beta Galactose metabolism carbon utilization (Woodcroft) sugar utilization lactose degradation 0 0 -K12309 beta-galactosidase Galactose metabolism carbon utilization (Woodcroft) sugar utilization lactose degradation 0 0 -K01203 sucrase-isomaltase Starch and sucrose metabolism carbon utilization (Woodcroft) sugar utilization sucrose degradation 0 0 -K01193 beta-fructofuranosidase Starch and sucrose metabolism carbon utilization (Woodcroft) sugar utilization sucrose degradation 0 0 -K12047 maltase-glucoamylase Starch and sucrose metabolism carbon utilization (Woodcroft) sugar utilization sucrose degradation 0 0 -K01187 alpha-glucosidase Starch and sucrose metabolism carbon utilization (Woodcroft) sugar utilization sucrose degradation 0 0 -K12316 lysosomal alpha-glucosidase Starch and sucrose metabolism carbon utilization (Woodcroft) sugar utilization sucrose degradation 0 0 -K12317 neutral alpha-glucosidase C Starch and sucrose metabolism carbon utilization (Woodcroft) sugar utilization sucrose degradation 0 0 -K15922 sulfoquinovosidase Starch and sucrose metabolism carbon utilization (Woodcroft) sugar utilization sucrose degradation 0 0 -K00690 sucrose phosphorylase Starch and sucrose metabolism carbon utilization (Woodcroft) sugar utilization sucrose degradation 0 0 -K00847 fructokinase Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization fructose degradation 0 0 -K00844 hexokinase Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization fructose degradation 0 0 -K00844 hexokinase Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization mannose degradation 0 0 -K02793 mannose PTS system EIIA component Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization mannose degradation 0 0 -K02794 mannose PTS system EIIAB component Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization mannose degradation 0 0 -K02795 mannose PTS system EIIC component Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization mannose degradation 0 0 -K02796 mannose PTS system EIID component Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization mannose degradation 0 0 -K01809 mannose-6-phosphate isomerase Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization mannose degradation 0 0 -K01818 L-fucose/D-arabinose isomerase Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization fucose degradation 0 0 -K00879 L-fuculokinase Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization fucose degradation 0 0 -K01628 L-fuculose-phosphate aldolase Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization fucose degradation 0 0 -K01805 xylose isomerase Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization xylose degradation (isomerase pathway) 0 0 -K00854 xylulokinase Fructose and mannose metabolism carbon utilization (Woodcroft) sugar utilization xylose degradation (isomerase pathway) 0 0 -K17743 D-xylose reductase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (oxidoreductase pathway) 0 0 -K00011 aldehyde reductase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (oxidoreductase pathway) 0 0 -K05351 D-xylulose reductase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (oxidoreductase pathway) 0 0 -K00008 L-iditol 2-dehydrogenase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (oxidoreductase pathway) 0 0 -K00854 xylulokinase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (oxidoreductase pathway) 0 0 -K14275 D-xylonate dehydratase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (xylonate hydratase pathway) 0 0 -K00078 dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (weimburg/dahms) 0 0 -K14273 D-xylose 1-dehydrogenase (NADP+) Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (weimburg/dahms) 0 0 -K14274 xylono-1,5-lactonase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (weimburg/dahms) 0 0 -K14275 D-xylonate dehydratase Pentose and glucuronate interconversions carbon utilization (Woodcroft) sugar utilization xylose degradation (weimburg/dahms) 0 0 -K01905 6.2.1.13, acetate---CoA ligase (ADP-forming) subunit alpha SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K01067 acetyl-CoA hydrolase [EC:3.1.2.1] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K00101 L-lactate dehydrogenase (cytochrome) [EC:1.1.2.3] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K03777 D-lactate dehydrogenase (quinone) [EC:1.1.5.12] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K00634 phosphate butyryltransferase [EC:2.3.1.19] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K00929 butyrate kinase [EC:2.7.2.7] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K01896 medium-chain acyl-CoA synthetase [EC:6.2.1.2] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K19697 propionate kinase [EC:2.7.2.15] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K01026 propionate CoA-transferase [EC:2.8.3.1] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K18857 alcohol dehydrogenase [EC:1.1.1.1] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K13980 alcohol dehydrogenase [EC:1.1.1.1] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K13953 alcohol dehydrogenase [EC:1.1.1.1] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K13952 alcohol dehydrogenase [EC:1.1.1.1] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K13951 alcohol dehydrogenase [EC:1.1.1.1] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K04072 alcohol dehydrogenase [EC:1.1.1.1] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K00121 alcohol dehydrogenase [EC:1.1.1.1] SCFA and alcohol conversions MISC SCFA and alcohol conversions 0 0 -K13811 sulfate adenylyltransferase [EC:2.7.7.4] [RN:R00529] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00958 sulfate adenylyltransferase [EC:2.7.7.4] [RN:R00529] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00860 adenylylsulfate kinase [EC:2.7.1.25] [RN:R00509] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00955 sulfate adenylyltransferase [EC:2.7.7.4] [RN:R00529] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00957 sulfate adenylyltransferase [EC:2.7.7.4] [RN:R00529] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00956 sulfate adenylyltransferase [EC:2.7.7.4] [RN:R00529] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00390 phosphoadenosine phosphosulfate reductase [EC:1.8.4.8] [RN:R02021] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00380 sulfite reductase (NADPH) [EC:1.8.1.2] [RN:R00858] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00381 sulfite reductase (NADPH) [EC:1.8.1.2] [RN:R00858] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00392 sulfite reductase (ferredoxin) [EC:1.8.7.1] [RN:R00859] Assimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K17222 soxA; sulfur-oxidizing protein SoxA Thiosulfate oxidation by SOX complex, thiosulfate => sulfate Energy Sulfur 0 0 -K17223 soxX; sulfur-oxidizing protein SoxX Thiosulfate oxidation by SOX complex, thiosulfate => sulfate Energy Sulfur 0 0 -K17224 soxB; sulfur-oxidizing protein SoxB Thiosulfate oxidation by SOX complex, thiosulfate => sulfate Energy Sulfur 0 0 -K17225 soxC; S-disulfanyl-L-cysteine oxidoreductase SoxC [EC:1.8.2.6] Thiosulfate oxidation by SOX complex, thiosulfate => sulfate Energy Sulfur 0 0 -K22622 soxD; S-disulfanyl-L-cysteine oxidoreductase SoxD [EC:1.8.2.6] Thiosulfate oxidation by SOX complex, thiosulfate => sulfate Energy Sulfur 0 0 -K17226 soxY; sulfur-oxidizing protein SoxY Thiosulfate oxidation by SOX complex, thiosulfate => sulfate Energy Sulfur 0 0 -K17227 soxZ; sulfur-oxidizing protein SoxZ Thiosulfate oxidation by SOX complex, thiosulfate => sulfate Energy Sulfur 0 0 -K00956 sulfate adenylyltransferase [EC:2.7.7.4] [RN:R00529] Dissimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00957 sulfate adenylyltransferase [EC:2.7.7.4] [RN:R00529] Dissimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00958 sulfate adenylyltransferase [EC:2.7.7.4] [RN:R00529] Dissimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00394 adenylylsulfate reductase [EC:1.8.99.2] [RN:R08553] Dissimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K00395 adenylylsulfate reductase [EC:1.8.99.2] [RN:R08553] Dissimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K11180 sulfite reductase, dissimilatory-type [EC:1.8.99.5] [RN:R00861] Dissimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K11181 sulfite reductase, dissimilatory-type [EC:1.8.99.5] [RN:R00861] Dissimilatory sulfate reduction, sulfate => H2S Energy Sulfur 0 0 -K08352 thiosulfate reductase / polysulfide reductase chain A [EC:1.8.5.5] Energy Sulfur 0 0 -K01011 rhodanase Energy Sulfur 0 0 -K08357 tetrathionate => thiosulfate Energy Sulfur 0 0 -K02703 psbA; photosystem II reaction center D1 protein [EC:1.10.3.9] Photosystem II Energy Photosynthesis 0 0 -K02706 psbD; photosystem II reaction center D2 protein [EC:1.10.3.9] Photosystem II Energy Photosynthesis 0 0 -K02705 psbC; photosystem II CP43 chlorophyll apoprotein Photosystem II Energy Photosynthesis 0 0 -K02704 psbB; photosystem II CP47 chlorophyll apoprotein Photosystem II Energy Photosynthesis 0 0 -K02707 psbE; photosystem II cytochrome b559 subunit alpha Photosystem II Energy Photosynthesis 0 0 -K02708 psbF; photosystem II cytochrome b559 subunit beta Photosystem II Energy Photosynthesis 0 0 -K02635 cytochrome b6 Cytochrome b6f complex Energy Photosynthesis 0 0 -K02637 cytochrome b6-f complex subunit 4 Cytochrome b6f complex Energy Photosynthesis 0 0 -K02634 apocytochrome f Cytochrome b6f complex Energy Photosynthesis 0 0 -K02636 cytochrome b6-f complex iron-sulfur subunit Cytochrome b6f complex Energy Photosynthesis 0 0 -K02642 cytochrome b6-f complex subunit 6 Cytochrome b6f complex Energy Photosynthesis 0 0 -K02643 cytochrome b6-f complex subunit 7 Cytochrome b6f complex Energy Photosynthesis 0 0 -K03689 cytochrome b6-f complex subunit 8 Cytochrome b6f complex Energy Photosynthesis 0 0 -K02640 cytochrome b6-f complex subunit 5 Cytochrome b6f complex Energy Photosynthesis 0 0 -K02689 psaA; photosystem I P700 chlorophyll a apoprotein A1 Photosystem I Energy Photosynthesis 0 0 -K02690 psaB; photosystem I P700 chlorophyll a apoprotein A2 Photosystem I Energy Photosynthesis 0 0 -K02691 psaC; photosystem I subunit VII Photosystem I Energy Photosynthesis 0 0 -K02692 psaD; photosystem I subunit II Photosystem I Energy Photosynthesis 0 0 -K02693 psaE; photosystem I subunit IV Photosystem I Energy Photosynthesis 0 0 -K02694 psaF; photosystem I subunit III Photosystem I Energy Photosynthesis 0 0 -K00281 glycine cleavage system [RN:R01221] Photorespiration Energy Photosynthesis 0 0 -K00283 glycine cleavage system [RN:R01221] Photorespiration Energy Photosynthesis 0 0 -K00605 glycine cleavage system [RN:R01221] Photorespiration Energy Photosynthesis 0 0 -K00382 glycine cleavage system [RN:R01221] Photorespiration Energy Photosynthesis 0 0 -K02437 glycine cleavage system [RN:R01221] Photorespiration Energy Photosynthesis 0 0 -K08928 pufL; photosynthetic reaction center L subunit Anoxygenic photosystem II Energy Photosynthesis 0 0 -K08929 pufM; photosynthetic reaction center M subunit Anoxygenic photosystem II Energy Photosynthesis 0 0 -K08940 pscA; photosystem P840 reaction center large subunit Anoxygenic photosystem I Energy Photosynthesis 0 0 -K08941 pscB; photosystem P840 reaction center iron-sulfur protein Anoxygenic photosystem I Energy Photosynthesis 0 0 -K08942 pscC; photosystem P840 reaction center cytochrome c551 Anoxygenic photosystem I Energy Photosynthesis 0 0 -K08943 pscD; photosystem P840 reaction center protein PscD Anoxygenic photosystem I Energy Photosynthesis 0 0 -K02638 plastocyanin Cytochrome b6f complex Energy Photosynthesis 0 0 -K02639 ferredoxin Cytochrome b6f complex Energy Photosynthesis 0 0 -K02641 ferredoxin--NADP+ reductase Cytochrome b6f complex Energy Photosynthesis 0 0 -K00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K00413 CYC1; ubiquinol-cytochrome c reductase cytochrome c1 subunit Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K00410 fbcH; ubiquinol-cytochrome c reductase cytochrome b/c1 subunit Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K00411 UQCRFS1; ubiquinol-cytochrome c reductase iron-sulfur subunit Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K03886 MQCRA; menaquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.-] Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K03887 MQCRB; menaquinol-cytochrome c reductase cytochrome b subunit Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K03888 MQCRC; menaquinol-cytochrome c reductase cytochrome b/c subunit Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K03890 qcrA; ubiquinol-cytochrome c reductase iron-sulfur subunit Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K03891 qcrB; ubiquinol-cytochrome c reductase cytochrome b subunit Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K03889 qcrC; ubiquinol-cytochrome c reductase cytochrome c subunit Cytochrome bc1 complex respiratory unit Energy Oxygen 0 0 -K00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit Cytochrome bc1 complex Energy Oxygen 0 0 -K00413 CYC1; ubiquinol-cytochrome c reductase cytochrome c1 subunit Cytochrome bc1 complex Energy Oxygen 0 0 -K00410 FBCH; ubiquinol-cytochrome c reductase cytochrome b/c1 subunit Cytochrome bc1 complex Energy Oxygen 0 0 -K00411 UQCRFS1; ubiquinol-cytochrome c reductase iron-sulfur subunit Cytochrome bc1 complex Energy Oxygen 0 0 -K00414 QCR1; ubiquinol-cytochrome c reductase core subunit 1 Cytochrome bc1 complex Energy Oxygen 0 0 -K00415 QCR2; ubiquinol-cytochrome c reductase core subunit 2 Cytochrome bc1 complex Energy Oxygen 0 0 -K00416 QCR6; ubiquinol-cytochrome c reductase subunit 6 Cytochrome bc1 complex Energy Oxygen 0 0 -K00417 QCR7; ubiquinol-cytochrome c reductase subunit 7 Cytochrome bc1 complex Energy Oxygen 0 0 -K00418 QCR8; ubiquinol-cytochrome c reductase subunit 8 Cytochrome bc1 complex Energy Oxygen 0 0 -K00419 QCR9; ubiquinol-cytochrome c reductase subunit 9 Cytochrome bc1 complex Energy Oxygen 0 0 -K00420 QCR10; ubiquinol-cytochrome c reductase subunit 10 Cytochrome bc1 complex Energy Oxygen 0 0 -K00425 cytochrome bd ubiquinol oxidase subunit I [EC:1.10.3.14] Cytochrome bd ubiquinol oxidase Energy Oxygen 0 0 -K00426 cytochrome bd ubiquinol oxidase subunit II [EC:1.10.3.14] Cytochrome bd ubiquinol oxidase Energy Oxygen 0 0 -K00424 cydX; cytochrome bd-I ubiquinol oxidase subunit X [EC:1.10.3.14] Cytochrome bd ubiquinol oxidase Energy Oxygen 0 0 -K22501 appX; cytochrome bd-II ubiquinol oxidase subunit AppX [EC:1.10.3.14] Cytochrome bd ubiquinol oxidase Energy Oxygen 0 0 -K02257 COX10; protoheme IX farnesyltransferase [EC:2.5.1.-] Cytochrome c oxidase Energy Oxygen 0 0 -K02262 COX3; cytochrome c oxidase subunit 3 Cytochrome c oxidase Energy Oxygen 0 0 -K02256 COX1; cytochrome c oxidase subunit 1 [EC:1.9.3.1] Cytochrome c oxidase Energy Oxygen 0 0 -K02261 COX2; cytochrome c oxidase subunit 2 Cytochrome c oxidase Energy Oxygen 0 0 -K02263 COX4; cytochrome c oxidase subunit 4 Cytochrome c oxidase Energy Oxygen 0 0 -K02264 COX5A; cytochrome c oxidase subunit 5a Cytochrome c oxidase Energy Oxygen 0 0 -K02265 COX5B; cytochrome c oxidase subunit 5b Cytochrome c oxidase Energy Oxygen 0 0 -K02266 COX6A; cytochrome c oxidase subunit 6a Cytochrome c oxidase Energy Oxygen 0 0 -K02267 COX6B; cytochrome c oxidase subunit 6b Cytochrome c oxidase Energy Oxygen 0 0 -K02268 COX6C; cytochrome c oxidase subunit 6c Cytochrome c oxidase Energy Oxygen 0 0 -K02269 COX7; cytochrome c oxidase subunit 7 Cytochrome c oxidase Energy Oxygen 0 0 -K02270 COX7A; cytochrome c oxidase subunit 7a Cytochrome c oxidase Energy Oxygen 0 0 -K02271 COX7B; cytochrome c oxidase subunit 7b Cytochrome c oxidase Energy Oxygen 0 0 -K02272 COX7C; cytochrome c oxidase subunit 7c Cytochrome c oxidase Energy Oxygen 0 0 -K02273 COX8; cytochrome c oxidase subunit 8 Cytochrome c oxidase Energy Oxygen 0 0 -K02258 COX11; cytochrome c oxidase assembly protein subunit 11 Cytochrome c oxidase Energy Oxygen 0 0 -K02259 COX15; cytochrome c oxidase assembly protein subunit 15 Cytochrome c oxidase Energy Oxygen 0 0 -K02260 COX17; cytochrome c oxidase assembly protein subunit 17 Cytochrome c oxidase Energy Oxygen 0 0 -K02275 coxB; cytochrome c oxidase subunit II [EC:1.9.3.1] Cytochrome c oxidase, prokaryotes Energy Oxygen 0 0 -K02274 coxA; cytochrome c oxidase subunit I [EC:1.9.3.1] Cytochrome c oxidase, prokaryotes Energy Oxygen 0 0 -K02276 coxC; cytochrome c oxidase subunit III [EC:1.9.3.1] Cytochrome c oxidase, prokaryotes Energy Oxygen 0 0 -K15408 coxAC; cytochrome c oxidase subunit I+III [EC:1.9.3.1] Cytochrome c oxidase, prokaryotes Energy Oxygen 0 0 -K02277 coxD; cytochrome c oxidase subunit IV [EC:1.9.3.1] Cytochrome c oxidase, prokaryotes Energy Oxygen 0 0 -K00404 ccoN; cb-type cytochrome c oxidase subunit I [EC:1.9.3.1] Cytochrome c oxidase, cbb3-type Energy Oxygen 0 0 -K00405 ccoO; cb-type cytochrome c oxidase subunit II Cytochrome c oxidase, cbb3-type Energy Oxygen 0 0 -K15862 ccoNO; cbb3-type cytochrome c oxidase subunit I/II Cytochrome c oxidase, cbb3-type Energy Oxygen 0 0 -K00407 ccoQ; cb-type cytochrome c oxidase subunit IV Cytochrome c oxidase, cbb3-type Energy Oxygen 0 0 -K00406 ccoP; cb-type cytochrome c oxidase subunit III Cytochrome c oxidase, cbb3-type Energy Oxygen 0 0 -K02827 qoxB; cytochrome aa3-600 menaquinol oxidase subunit I [EC:1.10.3.12] Cytochrome aa3-600 menaquinol oxidase Energy Oxygen 0 0 -K02826 qoxA; cytochrome aa3-600 menaquinol oxidase subunit II [EC:1.10.3.12] Cytochrome aa3-600 menaquinol oxidase Energy Oxygen 0 0 -K02828 qoxC; cytochrome aa3-600 menaquinol oxidase subunit III [EC:1.10.3.12] Cytochrome aa3-600 menaquinol oxidase Energy Oxygen 0 0 -K02829 qoxD; cytochrome aa3-600 menaquinol oxidase subunit IV [EC:1.10.3.12] Cytochrome aa3-600 menaquinol oxidase Energy Oxygen 0 0 -K02297 cyoA; cytochrome o ubiquinol oxidase subunit II [EC:1.10.3.10] Cytochrome o ubiquinol oxidase Energy Oxygen 0 0 -K02298 cyoB; cytochrome o ubiquinol oxidase subunit I [EC:1.10.3.10] Cytochrome o ubiquinol oxidase Energy Oxygen 0 0 -K02299 cyoC; cytochrome o ubiquinol oxidase subunit III Cytochrome o ubiquinol oxidase Energy Oxygen 0 0 -K02300 cyoD; cytochrome o ubiquinol oxidase operon protein cyoD Cytochrome o ubiquinol oxidase Energy Oxygen 0 0 -K00937 polyphosphate kinase ??? Cytochrome d ubiquinol oxidase Energy Oxygen 0 0 -K20932 hzs; Hydrazine synthase subunit (aka: hzsC) [EC:1.7.2.7] [RN:R09799] Nitrification, ammonia => nitrite Energy Nitrogen 0 0 -K20933 hzs; Hydrazine synthase subunit (aka: hzsC) [EC:1.7.2.7] [RN:R09799] Nitrification, ammonia => nitrite Energy Nitrogen 0 0 -K20934 hzs; Hydrazine synthase subunit (aka: hzsC) [EC:1.7.2.7] [RN:R09799] Nitrification, ammonia => nitrite Energy Nitrogen 0 0 -K20935 hzs; Hydrazine synthase subunit (aka: hzsC) [EC:1.7.2.7] [RN:R09799] Nitrification, ammonia => nitrite Energy Nitrogen 0 0 -K02588 nitrogenase iron protein [RN:R05185] Nitrogen fixation, nitrogen => ammonia Energy Nitrogen 0 0 -K02586 nitrogenase molybdenum-iron protein [EC:1.18.6.1] [RN:R05185] Nitrogen fixation, nitrogen => ammonia Energy Nitrogen 0 0 -K02591 nitrogenase molybdenum-iron protein [EC:1.18.6.1] [RN:R05185] Nitrogen fixation, nitrogen => ammonia Energy Nitrogen 0 0 -K00531 nitrogenase delta subunit [EC:1.18.6.1] [RN:R05185] Nitrogen fixation, nitrogen => ammonia Energy Nitrogen 0 0 -K22896 vanadium-dependent nitrogenase [EC:1.18.6.2] [RN:R12084] Nitrogen fixation, nitrogen => ammonia Energy Nitrogen 0 0 -K22897 vanadium-dependent nitrogenase [EC:1.18.6.2] [RN:R12084] Nitrogen fixation, nitrogen => ammonia Energy Nitrogen 0 0 -K22898 vanadium nitrogenase delta subunit [EC:1.18.6.2] [RN:R12084] Nitrogen fixation, nitrogen => ammonia Energy Nitrogen 0 0 -K22899 vanadium nitrogenase iron protein [RN:R12084] Nitrogen fixation, nitrogen => ammonia Energy Nitrogen 0 0 -K10944 ammonia monooxygenase [EC:1.14.99.39] [RN:R00148] Nitrification, ammonia => nitrite Energy Nitrogen 0 0 -K10945 ammonia monooxygenase [EC:1.14.99.39] [RN:R00148] Nitrification, ammonia => nitrite Energy Nitrogen 0 0 -K10946 ammonia monooxygenase [EC:1.14.99.39] [RN:R00148] Nitrification, ammonia => nitrite Energy Nitrogen 0 0 -K10535 hydroxylamine oxidase [EC:1.7.2.6] [RN:R10164] Nitrification, ammonia => nitrite Energy Nitrogen 0 0 -K00370 nitrate reductase 1 [EC:1.7.99.-] [RN:R00798] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K00371 nitrate reductase 1 [EC:1.7.99.-] [RN:R00798] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K00374 nitrate reductase 1 [EC:1.7.99.-] [RN:R00798] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K02567 periplasmic nitrate reductase NapA [EC:1.7.99.-] [RN:R00798] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K02568 cytochrome c-type protein NapB [RN:R00798] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K00368 nitrite reductase (NO-forming) [EC:1.7.2.1] [RN:R00783 R00785] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K15864 nitrite reductase (NO-forming) [EC:1.7.2.1] [RN:R00783 R00785] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K04561 nitric oxide reductase [EC:1.7.2.5] [RN:R00294] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K02305 nitric oxide reductase [EC:1.7.2.5] [RN:R00294] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K15877 fungal nitric oxide reductase [EC:1.7.1.14] [RN:R02492 R09446 R09808 R09809] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K00376 nitrous-oxide reductase [EC:1.7.2.4] [RN:R02804] Denitrification, nitrate => nitrogen Energy Nitrogen 0 0 -K00370 respiratory nitrate reductase 1 [EC:1.7.99.-] [RN:R00798] Dissimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K00371 respiratory nitrate reductase 1 [EC:1.7.99.-] [RN:R00798] Dissimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K00374 respiratory nitrate reductase 1 [EC:1.7.99.-] [RN:R00798] Dissimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K02567 dissimilatory nitrate reductase [EC:1.7.99.-] [RN:R00798] Dissimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K02568 dissimilatory nitrate reductase [EC:1.7.99.-] [RN:R00798] Dissimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K00362 respiratory nitrite reductase [EC:1.7.1.15] [RN:R00787] Dissimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K00363 respiratory nitrite reductase [EC:1.7.1.15] [RN:R00787] Dissimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K03385 respiratory nitrite reductase [EC:1.7.2.2] [RN:R05712] Dissimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K15876 respiratory nitrite reductase [EC:1.7.2.2] [RN:R05712] Dissimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K00367 assimilatory nitrate reductase [EC:1.7.7.2] [RN:R00791] Assimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K10534 nitrate reductase (NAD(P)H) [EC:1.7.1.1 1.7.1.2 1.7.1.3] [RN:R00794 R00796] Assimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K00372 assimilatory nitrate reductase [EC:1.7.99.-] [RN:R00798] Assimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K00360 assimilatory nitrate reductase [EC:1.7.99.-] [RN:R00798] Assimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K00366 assimilatory nitrite reductase [EC:1.7.7.1] [RN:R00790] Assimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K17877 assimilatory nitrite reductase [EC:1.7.1.4] [RN:R00787 R00789] Assimilatory nitrate reduction, nitrate => ammonia Energy Nitrogen 0 0 -K02575 NRT; MFS transporter, NNP family, nitrate/nitrite transporter Nitrate assimilation Energy Nitrogen 0 0 -K10944 ammonia monooxygenase [EC:1.14.99.39] [RN:R00148] Complete nitrification, comammox, ammonia => nitrite => nitrate Energy Nitrogen 0 0 -K10945 ammonia monooxygenase [EC:1.14.99.39] [RN:R00148] Complete nitrification, comammox, ammonia => nitrite => nitrate Energy Nitrogen 0 0 -K10946 ammonia monooxygenase [EC:1.14.99.39] [RN:R00148] Complete nitrification, comammox, ammonia => nitrite => nitrate Energy Nitrogen 0 0 -K10535 hydroxylamine oxidase [EC:1.7.2.6] [RN:R10164] Complete nitrification, comammox, ammonia => nitrite => nitrate Energy Nitrogen 0 0 -K00370 nitrite oxidoreductase [EC:1.7.99.4] [RN:R00798] Complete nitrification, comammox, ammonia => nitrite => nitrate Energy Nitrogen 0 0 -K00371 nitrite oxidoreductase [EC:1.7.99.4] [RN:R00798] Complete nitrification, comammox, ammonia => nitrite => nitrate Energy Nitrogen 0 0 -K20935 hdh; hydrazine dehydrogenase nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -K20932 hzs; Hydrazine synthase subunit (aka: hzsC) [EC:1.7.2.7] [RN:R09799] nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -K20933 hzs; Hydrazine synthase subunit (aka: hzsC) [EC:1.7.2.7] [RN:R09799] nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -K20934 hzs; Hydrazine synthase subunit (aka: hzsC) [EC:1.7.2.7] [RN:R09799] nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -K20935 hzs; Hydrazine synthase subunit (aka: hzsC) [EC:1.7.2.7] [RN:R09799] nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -K10535 hox, hydroxylamine oxidase [EC:1.7.2.6] [RN:R10164] nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -K00368 nir, nitrite reductase (NO-forming) [EC:1.7.2.1] [RN:R00783 R00785] nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -K15864 nir, nitrite reductase (NO-forming) [EC:1.7.2.1] [RN:R00783 R00785] nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -K00370 nxr, nitrite oxidoreductase [EC:1.7.99.4] [RN:R00798] nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -K00371 nxr, nitrite oxidoreductase [EC:1.7.99.4] [RN:R00798] nitrite + ammonia => nitrogen Energy Nitrogen nitrite + ammonia => nitrogen 0 0 -EC:1.16.1.1 mercury(II) reductase Mercury Energy Metal Reduction 0 0 -EC:1.20.4.1 arsenate reductase (glutaredoxin); ArsC (ambiguous) Arsenate Energy Metal Reduction 0 0 -EC:1.20.99.1 arsenate reductase (donor); arsenate:(acceptor) oxidoreductase Arsenate Energy Metal Reduction 0 0 -K17050 selenate/chlorate reductase subunit alpha[EC:1.97.1.9 1.97.1.1] Selenate/Chlorate Energy Metal Reduction 0 0 -K00436 NAD-reducing hydrogenase large subunit [EC:1.12.1.2] hydrogenase Energy Hydrogenases 0 0 -K00437 [NiFe] hydrogenase large subunit [EC:1.12.2.1] hydrogenase Energy Hydrogenases 0 0 -K00440 coenzyme F420 hydrogenase subunit alpha [EC:1.12.98.1] hydrogenase Energy Hydrogenases 0 0 -K00441 coenzyme F420 hydrogenase subunit beta [EC:1.12.98.1] hydrogenase Energy Hydrogenases 1 0 -K00442 coenzyme F420 hydrogenase subunit delta hydrogenase Energy Hydrogenases 0 0 -K00443 coenzyme F420 hydrogenase subunit gamma [EC:1.12.98.1] hydrogenase Energy Hydrogenases 1 0 -K00532 ferredoxin hydrogenase [EC:1.12.7.2] hydrogenase Energy Hydrogenases 0 0 -K00533 ferredoxin hydrogenase large subunit [EC:1.12.7.2] hydrogenase Energy Hydrogenases 0 0 -K00534 ferredoxin hydrogenase small subunit [EC:1.12.7.2] hydrogenase Energy Hydrogenases 0 0 -K05586 bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2] hydrogenase Energy Hydrogenases 0 0 -K05587 bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2] hydrogenase Energy Hydrogenases 0 0 -K05588 bidirectional [NiFe] hydrogenase diaphorase subunit [EC:7.1.1.2] hydrogenase Energy Hydrogenases 0 0 -K06441 ferredoxin hydrogenase gamma subunit [EC:1.12.7.2] hydrogenase Energy Hydrogenases 0 0 -K06862 energy-converting hydrogenase B subunit Q hydrogenase Energy Hydrogenases 0 0 -K13942 5,10-methenyltetrahydromethanopterin hydrogenase [EC:1.12.98.2] hydrogenase Energy Hydrogenases 0 0 -K14068 methanophenazine hydrogenase, large subunit [EC:1.12.98.3] hydrogenase Energy Hydrogenases 0 0 -K14069 methanophenazine hydrogenase, cytochrome b subunit [EC:1.12.98.3] hydrogenase Energy Hydrogenases 0 0 -K14070 methanophenazine hydrogenase [EC:1.12.98.3] hydrogenase Energy Hydrogenases 0 0 -K14086 ech hydrogenase subunit A hydrogenase Energy Hydrogenases 0 0 -K14087 ech hydrogenase subunit B hydrogenase Energy Hydrogenases 0 0 -K14088 ech hydrogenase subunit C hydrogenase Energy Hydrogenases 0 0 -K14089 ech hydrogenase subunit D hydrogenase Energy Hydrogenases 0 0 -K14090 ech hydrogenase subunit E hydrogenase Energy Hydrogenases 0 0 -K14091 ech hydrogenase subunit F hydrogenase Energy Hydrogenases 0 0 -K14092 energy-converting hydrogenase A subunit A hydrogenase Energy Hydrogenases 0 0 -K14093 energy-converting hydrogenase A subunit B hydrogenase Energy Hydrogenases 0 0 -K14094 energy-converting hydrogenase A subunit C hydrogenase Energy Hydrogenases 0 0 -K14095 energy-converting hydrogenase A subunit D hydrogenase Energy Hydrogenases 0 0 -K14096 energy-converting hydrogenase A subunit E hydrogenase Energy Hydrogenases 0 0 -K14097 energy-converting hydrogenase A subunit F hydrogenase Energy Hydrogenases 0 0 -K14098 energy-converting hydrogenase A subunit G hydrogenase Energy Hydrogenases 0 0 -K14099 energy-converting hydrogenase A subunit H hydrogenase Energy Hydrogenases 0 0 -K14100 energy-converting hydrogenase A subunit I hydrogenase Energy Hydrogenases 0 0 -K14101 energy-converting hydrogenase A subunit J hydrogenase Energy Hydrogenases 0 0 -K14102 energy-converting hydrogenase A subunit K hydrogenase Energy Hydrogenases 0 0 -K14103 energy-converting hydrogenase A subunit L hydrogenase Energy Hydrogenases 0 0 -K14104 energy-converting hydrogenase A subunit M hydrogenase Energy Hydrogenases 0 0 -K14105 energy-converting hydrogenase A subunit N hydrogenase Energy Hydrogenases 0 0 -K14106 energy-converting hydrogenase A subunit O hydrogenase Energy Hydrogenases 0 0 -K14107 energy-converting hydrogenase A subunit P hydrogenase Energy Hydrogenases 0 0 -K14108 energy-converting hydrogenase A subunit Q hydrogenase Energy Hydrogenases 0 0 -K14109 energy-converting hydrogenase A subunit R hydrogenase Energy Hydrogenases 0 0 -K14110 energy-converting hydrogenase B subunit A hydrogenase Energy Hydrogenases 0 0 -K14111 energy-converting hydrogenase B subunit B hydrogenase Energy Hydrogenases 0 0 -K14112 energy-converting hydrogenase B subunit C hydrogenase Energy Hydrogenases 0 0 -K14113 energy-converting hydrogenase B subunit D hydrogenase Energy Hydrogenases 0 0 -K14114 energy-converting hydrogenase B subunit E hydrogenase Energy Hydrogenases 0 0 -K14115 energy-converting hydrogenase B subunit F hydrogenase Energy Hydrogenases 0 0 -K14116 energy-converting hydrogenase B subunit G hydrogenase Energy Hydrogenases 0 0 -K14117 energy-converting hydrogenase B subunit H hydrogenase Energy Hydrogenases 0 0 -K14118 energy-converting hydrogenase B subunit I hydrogenase Energy Hydrogenases 0 0 -K14119 energy-converting hydrogenase B subunit J hydrogenase Energy Hydrogenases 0 0 -K14120 energy-converting hydrogenase B subunit K hydrogenase Energy Hydrogenases 0 0 -K14121 energy-converting hydrogenase B subunit L hydrogenase Energy Hydrogenases 0 0 -K14122 energy-converting hydrogenase B subunit M hydrogenase Energy Hydrogenases 0 0 -K14123 energy-converting hydrogenase B subunit N hydrogenase Energy Hydrogenases 0 0 -K14124 energy-converting hydrogenase B subunit O hydrogenase Energy Hydrogenases 0 0 -K14125 energy-converting hydrogenase B subunit P hydrogenase Energy Hydrogenases 0 0 -K14126 F420-non-reducing hydrogenase large subunit [EC:1.12.99.- 1.8.98.5] hydrogenase Energy Hydrogenases 0 0 -K14127 F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.12.99.- 1.8.98.5 1.8.98.6] hydrogenase Energy Hydrogenases 1 0 -K14128 F420-non-reducing hydrogenase small subunit [EC:1.12.99.- 1.8.98.5] hydrogenase Energy Hydrogenases 0 0 -K17992 NADP-reducing hydrogenase subunit HndB [EC:1.12.1.3] hydrogenase Energy Hydrogenases 0 0 -K18005 [NiFe] hydrogenase diaphorase moiety large subunit [EC:1.12.1.2] hydrogenase Energy Hydrogenases 0 0 -K18006 [NiFe] hydrogenase diaphorase moiety small subunit [EC:1.12.1.2] hydrogenase Energy Hydrogenases 0 0 -K18007 NAD-reducing hydrogenase small subunit [EC:1.12.1.2] hydrogenase Energy Hydrogenases 0 0 -K18008 [NiFe] hydrogenase small subunit [EC:1.12.2.1] hydrogenase Energy Hydrogenases 0 0 -K18016 membrane-bound hydrogenase subunit alpha [EC:1.12.7.2] hydrogenase Energy Hydrogenases 0 0 -K18017 membrane-bound hydrogenase subunit beta [EC:1.12.7.2] hydrogenase Energy Hydrogenases 0 0 -K18023 membrane-bound hydrogenase subunit mbhJ [EC:1.12.7.2] hydrogenase Energy Hydrogenases 0 0 -K18330 NADP-reducing hydrogenase subunit HndA [EC:1.12.1.3] hydrogenase Energy Hydrogenases 0 0 -K18331 NADP-reducing hydrogenase subunit HndC [EC:1.12.1.3] hydrogenase Energy Hydrogenases 0 0 -K18332 NADP-reducing hydrogenase subunit HndD [EC:1.12.1.3] hydrogenase Energy Hydrogenases 0 0 -K19640 putative two-component system protein, hydrogenase maturation factor HypX/HoxX hydrogenase Energy Hydrogenases 0 0 -K23548 uptake hydrogenase small subunit [EC:1.12.99.6] hydrogenase Energy Hydrogenases 0 0 -K23549 uptake hydrogenase large subunit [EC:1.12.99.6] hydrogenase Energy Hydrogenases 0 0 -K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] [RN:R04432] Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA Energy Electron transport Chain 0 0 -K07511 enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03045] Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA Energy Electron transport Chain 0 0 -K07514 enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03045] Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA Energy Electron transport Chain 0 0 -K07515 enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03045] Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA Energy Electron transport Chain 0 0 -K14729 multifunctional beta-oxidation protein [EC:4.2.1.-] [RN:R03045] Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA Energy Electron transport Chain 0 0 -K05605 3-hydroxyisobutyryl-CoA hydrolase [EC:3.1.2.4] [RN:R03157 R03158] Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA Energy Electron transport Chain 0 0 -K23146 3-hydroxypropionate dehydrogenase [EC:1.1.1.59] [RN:R01608] Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA Energy Electron transport Chain 0 0 -K00140 malonate-semialdehyde dehydrogenase (acetylating) [EC:1.2.1.18] [RN:R00740] Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA Energy Electron transport Chain 0 0 -K00330 nuoA; NADH-quinone oxidoreductase subunit A [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00331 nuoB; NADH-quinone oxidoreductase subunit B [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00332 nuoC; NADH-quinone oxidoreductase subunit C [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00333 nuoD; NADH-quinone oxidoreductase subunit D [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K13378 nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K13380 nuoBCD; NADH-quinone oxidoreductase subunit B/C/D [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00334 nuoE; NADH-quinone oxidoreductase subunit E [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00335 nuoF; NADH-quinone oxidoreductase subunit F [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00336 nuoG; NADH-quinone oxidoreductase subunit G [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00337 nuoH; NADH-quinone oxidoreductase subunit H [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00338 nuoI; NADH-quinone oxidoreductase subunit I [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00339 nuoJ; NADH-quinone oxidoreductase subunit J [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00340 nuoK; NADH-quinone oxidoreductase subunit K [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00341 nuoL; NADH-quinone oxidoreductase subunit L [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00342 nuoM; NADH-quinone oxidoreductase subunit M [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K15863 nuoLM; NADH-quinone oxidoreductase subunit L/M [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K00343 nuoN; NADH-quinone oxidoreductase subunit N [EC:7.1.1.2] NADH:quinone oxidoreductase, prokaryotes Energy Electron transport Chain 0 0 -K05574 ndhC; NAD(P)H-quinone oxidoreductase subunit 3 [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05582 ndhK; NAD(P)H-quinone oxidoreductase subunit K [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05581 ndhJ; NAD(P)H-quinone oxidoreductase subunit J [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05579 ndhH; NAD(P)H-quinone oxidoreductase subunit H [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05572 ndhA; NAD(P)H-quinone oxidoreductase subunit 1 [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05580 ndhI; NAD(P)H-quinone oxidoreductase subunit I [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05578 ndhG; NAD(P)H-quinone oxidoreductase subunit 6 [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05576 ndhE; NAD(P)H-quinone oxidoreductase subunit 4L [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05577 ndhF; NAD(P)H-quinone oxidoreductase subunit 5 [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05575 ndhD; NAD(P)H-quinone oxidoreductase subunit 4 [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05573 ndhB; NAD(P)H-quinone oxidoreductase subunit 2 [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05583 ndhL; NAD(P)H-quinone oxidoreductase subunit L [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05584 ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K05585 ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2] NAD(P)H:quinone oxidoreductase, chloroplasts and cyanobacteria Energy Electron transport Chain 0 0 -K00236 SDHC; succinate dehydrogenase (ubiquinone) cytochrome b560 subunit Succinate dehydrogenase (ubiquinone) Energy Electron transport Chain 0 0 -K00237 SDHD; succinate dehydrogenase (ubiquinone) membrane anchor subunit Succinate dehydrogenase (ubiquinone) Energy Electron transport Chain 0 0 -K00234 SDHA; succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1] Succinate dehydrogenase (ubiquinone) Energy Electron transport Chain 0 0 -K00235 SDHB; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1] Succinate dehydrogenase (ubiquinone) Energy Electron transport Chain 0 0 -K00241 sdhC; succinate dehydrogenase cytochrome b556 subunit Succinate dehydrogenase, prokaryotes Energy Electron transport Chain 0 0 -K00242 sdhD; succinate dehydrogenase membrane anchor subunit Succinate dehydrogenase, prokaryotes Energy Electron transport Chain 0 0 -K00239 sdhA; succinate dehydrogenase flavoprotein subunit [EC:1.3.5.1] Succinate dehydrogenase, prokaryotes Energy Electron transport Chain 0 0 -K00240 sdhB; succinate dehydrogenase iron-sulfur subunit [EC:1.3.5.1] Succinate dehydrogenase, prokaryotes Energy Electron transport Chain 0 0 -K00244 frdA; fumarate reductase flavoprotein subunit [EC:1.3.5.4] Fumarate reductase, prokaryotes Energy Electron transport Chain 0 0 -K00245 frdB; fumarate reductase iron-sulfur subunit [EC:1.3.5.4] Fumarate reductase, prokaryotes Energy Electron transport Chain 0 0 -K00246 frdC; fumarate reductase subunit C Fumarate reductase, prokaryotes Energy Electron transport Chain 0 0 -K00247 frdD; fumarate reductase subunit D Fumarate reductase, prokaryotes Energy Electron transport Chain 0 0 -K02111 ATPF1A; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14] F-type ATPase, prokaryotes and chloroplasts Energy Electron transport Chain 0 0 -K02112 ATPF1B; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14] F-type ATPase, prokaryotes and chloroplasts Energy Electron transport Chain 0 0 -K02113 ATPF1D; F-type H+-transporting ATPase subunit delta F-type ATPase, prokaryotes and chloroplasts Energy Electron transport Chain 0 0 -K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon F-type ATPase, prokaryotes and chloroplasts Energy Electron transport Chain 0 0 -K02115 ATPF1G, atpG F-type ATPase, prokaryotes and chloroplasts Energy Electron transport Chain 0 0 -K02108 ATPF0A; F-type H+-transporting ATPase subunit a F-type ATPase, prokaryotes and chloroplasts Energy Electron transport Chain 0 0 -K02109 ATPF0B; F-type H+-transporting ATPase subunit b F-type ATPase, prokaryotes and chloroplasts Energy Electron transport Chain 0 0 -K02110 ATPF0C; F-type H+-transporting ATPase subunit c F-type ATPase, prokaryotes and chloroplasts Energy Electron transport Chain 0 0 -K02117 ATPVA; V/A-type H+-transporting ATPase subunit A [EC:3.6.3.14] V/A-type ATPase, prokaryotes Energy Electron transport Chain 0 0 -K02118 ATPVB; V/A-type H+-transporting ATPase subunit B V/A-type ATPase, prokaryotes Energy Electron transport Chain 0 0 -K02119 ATPVC; V/A-type H+-transporting ATPase subunit C V/A-type ATPase, prokaryotes Energy Electron transport Chain 0 0 -K02120 ATPVD; V/A-type H+-transporting ATPase subunit D V/A-type ATPase, prokaryotes Energy Electron transport Chain 0 0 -K02121 ATPVE; V/A-type H+-transporting ATPase subunit E V/A-type ATPase, prokaryotes Energy Electron transport Chain 0 0 -K02122 ATPVF; V/A-type H+-transporting ATPase subunit F V/A-type ATPase, prokaryotes Energy Electron transport Chain 0 0 -K02107 ATPVG; V/A-type H+-transporting ATPase subunit G/H V/A-type ATPase, prokaryotes Energy Electron transport Chain 0 0 -K02123 ATPVI; V/A-type H+-transporting ATPase subunit I V/A-type ATPase, prokaryotes Energy Electron transport Chain 0 0 -K02124 ATPVK; V/A-type H+-transporting ATPase subunit K V/A-type ATPase, prokaryotes Energy Electron transport Chain 0 0 -K00346 Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC:1.6.5.-] Na+-transporting NADH:ubiquinone oxidoreductase- Energy Electron transport Chain 0 0 -K00347 Na+-transporting NADH:ubiquinone oxidoreductase subunit B [EC:1.6.5.-] Na+-transporting NADH:ubiquinone oxidoreductase- Energy Electron transport Chain 0 0 -K00348 Na+-transporting NADH:ubiquinone oxidoreductase subunit C [EC:1.6.5.-] Na+-transporting NADH:ubiquinone oxidoreductase- Energy Electron transport Chain 0 0 -K00349 Na+-transporting NADH:ubiquinone oxidoreductase subunit D [EC:1.6.5.-] Na+-transporting NADH:ubiquinone oxidoreductase- Energy Electron transport Chain 0 0 -K00350 Na+-transporting NADH:ubiquinone oxidoreductase subunit E [EC:1.6.5.-] Na+-transporting NADH:ubiquinone oxidoreductase- Energy Electron transport Chain 0 0 -K00351 Na+-transporting NADH:ubiquinone oxidoreductase subunit F [EC:1.6.5.-] Na+-transporting NADH:ubiquinone oxidoreductase- Energy Electron transport Chain 0 0 -K05565 multicomponent Na+:H+ antiporter subunit A Multicomponent Na+/H+ antiporter Energy Electron transport Chain 0 0 -K05568 multicomponent Na+:H+ antiporter subunit D Multicomponent Na+/H+ antiporter Energy Electron transport Chain 0 0 -K05567 multicomponent Na+:H+ antiporter subunit C Multicomponent Na+/H+ antiporter Energy Electron transport Chain 0 0 -K05566 multicomponent Na+:H+ antiporter subunit B Multicomponent Na+/H+ antiporter Energy Electron transport Chain 0 0 -K05571 multicomponent Na+:H+ antiporter subunit G Multicomponent Na+/H+ antiporter Energy Electron transport Chain 0 0 -K05570 multicomponent Na+:H+ antiporter subunit F Multicomponent Na+/H+ antiporter Energy Electron transport Chain 0 0 -K05569 multicomponent Na+:H+ antiporter subunit E Multicomponent Na+/H+ antiporter Energy Electron transport Chain 0 0 -K03616 electron transport complex protein RnfB RNF complex Energy Electron transport Chain 0 0 -K03617 electron transport complex protein RnfA RNF complex Energy Electron transport Chain 0 0 -K03613 electron transport complex protein RnfE RNF complex Energy Electron transport Chain 0 0 -K03612 electron transport complex protein RnfG RNF complex Energy Electron transport Chain 0 0 -K03614 electron transport complex protein RnfD RNF complex Energy Electron transport Chain 0 0 -K03615 electron transport complex protein RnfC RNF complex Energy Electron transport Chain 0 0 -K03878 ND1; NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2] NADH:ubiquinone oxidoreductase, mitochondria Energy Electron transport Chain 0 0 -K03879 ND2; NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2] NADH:ubiquinone oxidoreductase, mitochondria Energy Electron transport Chain 0 0 -K03880 ND3; NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2] NADH:ubiquinone oxidoreductase, mitochondria Energy Electron transport Chain 0 0 -K03881 ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2] NADH:ubiquinone oxidoreductase, mitochondria Energy Electron transport Chain 0 0 -K03882 ND4L; NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2] NADH:ubiquinone oxidoreductase, mitochondria Energy Electron transport Chain 0 0 -K03883 ND5; NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2] NADH:ubiquinone oxidoreductase, mitochondria Energy Electron transport Chain 0 0 -K03884 ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2] NADH:ubiquinone oxidoreductase, mitochondria Energy Electron transport Chain 0 0 -K03934 NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2 1.6.99.3] NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03935 NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2 1.6.99.3] NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03936 NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2 1.6.99.3] NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03937 NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4 NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03938 NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5 NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03939 NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6 NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03940 NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2 1.6.99.3] NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03941 NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2 1.6.99.3] NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03942 NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2 1.6.99.3] NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03943 NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2 1.6.99.3] NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03944 NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3 NADH dehydrogenase (ubiquinone) Fe-S protein/flavoprotein complex, mitochondria Energy Electron transport Chain 0 0 -K03945 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03946 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03947 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03948 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03949 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03950 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03951 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03952 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03953 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03954 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03955 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03956 NADH-ubiquinone oxidoreductase subunit NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K11352 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K11353 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex Energy Electron transport Chain 0 0 -K03957 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03958 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03959 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03960 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03961 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03962 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03963 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03964 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03965 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03966 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K11351 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03967 NADH dehydrogenase (ubiquinone) 1 subcomplex unknown 1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K03968 NADH dehydrogenase (ubiquinone) 1 subcomplex unknown 2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex Energy Electron transport Chain 0 0 -K02132 ATPeF1A; F-type H+-transporting ATPase subunit alpha F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02133 ATPeF1B; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14] F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02136 ATPeF1G; F-type H+-transporting ATPase subunit gamma F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02134 ATPeF1D; F-type H+-transporting ATPase subunit delta F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02135 ATPeF1E; F-type H+-transporting ATPase subunit epsilon F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02137 ATPeF0O; F-type H+-transporting ATPase subunit O F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02126 ATPeF0A; F-type H+-transporting ATPase subunit a F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02127 ATPeF0B; F-type H+-transporting ATPase subunit b F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02128 ATPeF0C; F-type H+-transporting ATPase subunit c F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02138 ATPeFD; F-type H+-transporting ATPase subunit d F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02129 ATPeF0E; F-type H+-transporting ATPase subunit e F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K01549 TIM11; F-type H+-transporting ATP synthase subunit e F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02130 ATPeF0F; F-type H+-transporting ATPase subunit f F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02139 ATPeFF; F-type H+-transporting ATPase subunit f F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02140 ATPeFG; F-type H+-transporting ATPase subunit g F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02141 ATPeFH; F-type H+-transporting ATPase subunit h F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02131 ATPeF0F6; F-type H+-transporting ATPase subunit 6 F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02142 ATPeFJ; F-type H+-transporting ATPase subunit j F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02143 ATPeFK; F-type H+-transporting ATPase subunit k F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02125 ATPeF08; F-type H+-transporting ATPase subunit 8 F-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02145 ATPeV1A; V-type H+-transporting ATPase subunit A [EC:3.6.3.14] V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02147 ATPeV1B; V-type H+-transporting ATPase subunit B V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02148 ATPeV1C; V-type H+-transporting ATPase subunit C V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02149 ATPeV1D; V-type H+-transporting ATPase subunit D V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02150 ATPeV1E; V-type H+-transporting ATPase subunit E V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02151 ATPeV1F; V-type H+-transporting ATPase subunit F V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02152 ATPeV1G; V-type H+-transporting ATPase subunit G V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02144 ATPeV1H; V-type H+-transporting ATPase subunit H V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02154 ATPeV0A; V-type H+-transporting ATPase subunit a V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K03661 ATPeV0B; V-type H+-transporting ATPase 21kDa proteolipid subunit V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02155 ATPeV0C; V-type H+-transporting ATPase 16kDa proteolipid subunit V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02146 ATPeV0D; V-type H+-transporting ATPase subunit d V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K02153 ATPeV0E; V-type H+-transporting ATPase subunit e V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K03662 ATPeVS1; V-type H+-transporting ATPase S1 subunit V-type ATPase, eukaryotes Energy Electron transport Chain 0 0 -K16954 mtsA; methylthiol:coenzyme M methyltransferase [EC:2.1.1.251] Methanogenesis, methanethiol => methane Energy C1-methane 0 0 -K14080 [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase [EC:2.1.1.246] [RN:R09098] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K04480 methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase [EC:2.1.1.90] [RN:R09098] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K14081 methanol corrinoid protein [RN:R09098] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K00399 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K00401 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K00402 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K22480 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K22481 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K22482 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K03388 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, methanol => methane Energy C1-methane 4 0 -K03389 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K03390 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K08264 heterodisulfide reductase [EC:1.8.98.1] [RN:R04540] Methanogenesis, methanol => methane Energy C1-methane 1 0 -K08265 heterodisulfide reductase [EC:1.8.98.1] [RN:R04540] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K14127 F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944] Methanogenesis, methanol => methane Energy C1-methane 1 0 -K14126 F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K14128 F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K22516 formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K00125 formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944] Methanogenesis, methanol => methane Energy C1-methane 0 0 -K00925 acetate kinase [EC:2.7.2.1] [RN:R00315] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00625 phosphate acetyltransferase [EC:2.3.1.8] [RN:R00230] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K13788 phosphate acetyltransferase [EC:2.3.1.8] [RN:R00230] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K01895 acetyl-CoA synthetase [EC:6.2.1.1] [RN:R00235] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00193 acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R09096] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00197 acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R09096] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00194 acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R09096] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00577 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00578 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00579 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00580 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00581 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00582 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00583 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00584 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00399 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00401 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00402 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K22480 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K22481 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K22482 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K03388 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, acetate => methane Energy C1-methane 4 0 -K03389 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K03390 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K08264 heterodisulfide reductase [EC:1.8.98.1] [RN:R04540] Methanogenesis, acetate => methane Energy C1-methane 1 0 -K08265 heterodisulfide reductase [EC:1.8.98.1] [RN:R04540] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K14127 F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944] Methanogenesis, acetate => methane Energy C1-methane 1 0 -K14126 F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K14128 F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K22516 formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K00125 formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944] Methanogenesis, acetate => methane Energy C1-methane 0 0 -K14082 mtbA; [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase [EC:2.1.1.247] [RN:R09998] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K16177 mtmC; monomethylamine corrinoid protein [RN:R09998] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K16176 mtmB; methylamine---corrinoid protein Co-methyltransferase [EC:2.1.1.248] [RN:R09998] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K16179 mtbC; dimethylamine corrinoid protein [RN:R09999] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K16178 mtbB; dimethylamine---corrinoid protein Co-methyltransferase [EC:2.1.1.249] [RN:R09999] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K14084 mttC; trimethylamine corrinoid protein [RN:R09124] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K14083 mttB; trimethylamine---corrinoid protein Co-methyltransferase [EC:2.1.1.250] [RN:R09124] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K00399 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K00401 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K00402 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K22480 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K22481 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K22482 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K03388 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 4 0 -K03389 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K03390 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K08264 heterodisulfide reductase [EC:1.8.98.1] [RN:R04540] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 1 0 -K08265 heterodisulfide reductase [EC:1.8.98.1] [RN:R04540] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K14127 F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 1 0 -K14126 F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K14128 F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K22516 formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K00125 formate dehydrogenase (coenzyme F420) [EC:1.8.98.6] [RN:R11944] Methanogenesis, methylamine/dimethylamine/trimethylamine => methane Energy C1-methane 0 0 -K00200 formylmethanofuran dehydrogenase [EC:1.2.99.5] [RN:R03015] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00201 formylmethanofuran dehydrogenase [EC:1.2.99.5] [RN:R03015] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00202 formylmethanofuran dehydrogenase [EC:1.2.99.5] [RN:R03015] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00203 formylmethanofuran dehydrogenase [EC:1.2.99.5] [RN:R03015] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K11261 formylmethanofuran dehydrogenase [EC:1.2.99.5] [RN:R03015] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00205 4Fe-4S ferredoxin Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K11260 4Fe-4S ferredoxin Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00204 4Fe-4S ferredoxin Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00672 formylmethanofuran--tetrahydromethanopterin N-formyltransferase [EC:2.3.1.101] [RN:R03390] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K01499 methenyltetrahydromethanopterin cyclohydrolase [EC:3.5.4.27] [RN:R03464] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00319 methylenetetrahydromethanopterin dehydrogenase [EC:1.5.99.9] [RN:R04456] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K13942 5,10-methenyltetrahydromethanopterin hydrogenase [EC:1.12.98.2] [RN:R04455] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00320 coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase [EC:1.5.99.11] [RN:R04464] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00577 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00578 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00579 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00580 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00581 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00582 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00583 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00584 tetrahydromethanopterin S-methyltransferase [EC:2.1.1.86] [RN:R04347] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00399 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00401 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00402 methyl-coenzyme M reductase [EC:2.8.4.1] [RN:R04541] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K22480 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K22481 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K22482 heterodisulfide reductase 1 [EC:1.8.7.3] [RN:R11931] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K03388 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, CO2 => methane Energy C1-methane 4 0 -K03389 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K03390 heterodisulfide reductase 2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6] [RN:R11928 R11931 R11943 R11944] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K08264 heterodisulfide reductase [EC:1.8.98.1] [RN:R04540] Methanogenesis, CO2 => methane Energy C1-methane 1 0 -K08265 heterodisulfide reductase [EC:1.8.98.1] [RN:R04540] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K14127 F420-non-reducing hydrogenase iron-sulfur subunit [EC:1.8.98.5 1.8.98.6] [RN:R11943 R11944] Methanogenesis, CO2 => methane Energy C1-methane 1 0 -K14126 F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K14128 F420-non-reducing hydrogenase [EC:1.8.98.5] [RN:R11943] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K22516 formate dehydrogenase (coenzyme F420) [EC1.8.98.6] [RN:R11944] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K00125 formate dehydrogenase (coenzyme F420) [EC1.8.98.6] [RN:R11944] Methanogenesis, CO2 => methane Energy C1-methane 0 0 -K07811 trimethylamine-N-oxide reductase (cytochrome c) [EC:1.7.2.3] TMAO Energy C1 0 0 -K00855 phosphoribulokinase [EC:2.7.1.19] [RN:R01523] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K01601 ribulose-bisphosphate carboxylase [EC:4.1.1.39] [RN:R00024] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K01602 ribulose-bisphosphate carboxylase [EC:4.1.1.39] [RN:R00024] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K00927 phosphoglycerate kinase [EC:2.7.2.3] [RN:R01512] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K05298 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.13 1.2.1.59 1.2.1.12] [RN:R01061 R01063] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K00150 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.13 1.2.1.59 1.2.1.12] [RN:R01061 R01063] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K00134 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.13 1.2.1.59 1.2.1.12] [RN:R01061 R01063] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K01623 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01068 R01829] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K01624 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01068 R01829] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K03841 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K02446 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K11532 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K01086 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K04041 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K00615 transketolase [EC:2.2.1.1] [RN:R01067 R01641] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K01100 sedoheptulose-bisphosphatase [EC:3.1.3.37] [RN:R01845] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K01807 ribose 5-phosphate isomerase [EC:5.3.1.6] [RN:R01056] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K01808 ribose 5-phosphate isomerase [EC:5.3.1.6] [RN:R01056] Reductive pentose phosphate cycle (Calvin cycle) Energy C1 0 0 -K00855 phosphoribulokinase [EC:2.7.1.19] [RN:R01523] Reductive pentose phosphate cycle, ribulose-5P => glyceraldehyde-3P Energy C1 0 0 -K01601 ribulose-bisphosphate carboxylase [EC:4.1.1.39] [RN:R00024] Reductive pentose phosphate cycle, ribulose-5P => glyceraldehyde-3P Energy C1 0 0 -K01602 ribulose-bisphosphate carboxylase [EC:4.1.1.39] [RN:R00024] Reductive pentose phosphate cycle, ribulose-5P => glyceraldehyde-3P Energy C1 0 0 -K00927 phosphoglycerate kinase [EC:2.7.2.3] [RN:R01512] Reductive pentose phosphate cycle, ribulose-5P => glyceraldehyde-3P Energy C1 0 0 -K05298 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.13 1.2.1.59 1.2.1.12] [RN:R01061 R01063] Reductive pentose phosphate cycle, ribulose-5P => glyceraldehyde-3P Energy C1 0 0 -K00150 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.13 1.2.1.59 1.2.1.12] [RN:R01061 R01063] Reductive pentose phosphate cycle, ribulose-5P => glyceraldehyde-3P Energy C1 0 0 -K00134 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.13 1.2.1.59 1.2.1.12] [RN:R01061 R01063] Reductive pentose phosphate cycle, ribulose-5P => glyceraldehyde-3P Energy C1 0 0 -K01623 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01068 R01829] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K01624 fructose-bisphosphate aldolase [EC:4.1.2.13] [RN:R01068 R01829] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K03841 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K02446 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K11532 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K01086 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K04041 fructose-1,6-bisphosphatase [EC:3.1.3.11] [RN:R00762] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K00615 transketolase [EC:2.2.1.1] [RN:R01067 R01641] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K01100 sedoheptulose-bisphosphatase [EC:3.1.3.37] [RN:R01845] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K01807 ribose 5-phosphate isomerase [EC:5.3.1.6] [RN:R01056] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K01808 ribose 5-phosphate isomerase [EC:5.3.1.6] [RN:R01056] Reductive pentose phosphate cycle, glyceraldehyde-3P => ribulose-5P Energy C1 0 0 -K00169 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00170 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00171 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00172 pyruvate:ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K03737 pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-] [RN:R01196 R10866] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01007 pyruvate,water dikinase [EC:2.7.9.2] [RN:R00199] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01006 pyruvate,orthophosphate dikinase [EC:2.7.9.1] [RN:R00206] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01595 phosphoenolpyruvate carboxylase [EC:4.1.1.31] [RN:R00345] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01959 pyruvate carboxylase subunit A [EC:6.4.1.1] [RN:R00344] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01960 pyruvate carboxylase subunit A [EC:6.4.1.1] [RN:R00344] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01958 pyruvate carboxylase subunit A [EC:6.4.1.1] [RN:R00344] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00024 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01676 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01679 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01677 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01678 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00239 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00240 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00241 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00242 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00244 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00245 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00246 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00247 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K18556 NADH-dependent fumarate reductase [EC:1.3.1.6] [RN:R00402] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K18557 NADH-dependent fumarate reductase [EC:1.3.1.6] [RN:R00402] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K18558 NADH-dependent fumarate reductase [EC:1.3.1.6] [RN:R00402] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K18559 NADH-dependent fumarate reductase [EC:1.3.1.6] [RN:R00402] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K18560 NADH-dependent fumarate reductase [EC:1.3.1.6] [RN:R00402] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01902 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01903 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00174 2-oxoglutarate:ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00175 2-oxoglutarate:ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00177 2-oxoglutarate:ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00176 2-oxoglutarate:ferredoxin oxidoreductase [EC:1.2.7.3] [RN:R01197] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K00031 isocitrate dehydrogenase [EC:1.1.1.42] [RN:R00267] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01681 aconitate hydratase [EC:4.2.1.3] [RN:R01900 R01325] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K01682 aconitate hydratase [EC:4.2.1.3] [RN:R01900 R01325] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K15230 ATP-citrate lyase [EC:2.3.3.8] [RN:R00352] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K15231 ATP-citrate lyase [EC:2.3.3.8] [RN:R00352] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K15232 citryl-CoA synthetase [EC:6.2.1.18] [RN:R01322] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K15233 citryl-CoA synthetase [EC:6.2.1.18] [RN:R01322] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K15234 citryl-CoA lyase [EC:4.1.3.34] [RN:R00354] Reductive citrate cycle (Arnon-Buchanan cycle) Energy C1 0 0 -K10944 methane/ammonia monooxygenase [EC:1.14.18.3] [RN:R09518] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K10945 methane/ammonia monooxygenase [EC:1.14.18.3] [RN:R09518] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K10946 methane/ammonia monooxygenase [EC:1.14.18.3] [RN:R09518] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K16157 methane monooxygenase component A [EC:1.14.13.25] [RN:R01142] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K16158 methane monooxygenase component A [EC:1.14.13.25] [RN:R01142] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K16159 methane monooxygenase component A [EC:1.14.13.25] [RN:R01142] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K16160 methane monooxygenase regulatory protein B [RN:R01142] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K16161 methane monooxygenase component C [EC:1.14.13.25] [RN:R01142] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K16162 methane monooxygenase component D [RN:R01142] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K14028 methanol dehydrogenase [EC:1.1.2.7] [RN:R01146] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K14029 methanol dehydrogenase [EC:1.1.2.7] [RN:R01146] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K17066 alcohol oxidase [EC:1.1.3.13] [RN:R00608] Methane oxidation, methanotroph, methane => formaldehyde Energy C1 0 0 -K08097 phosphosulfolactate synthase [EC:4.4.1.19] [RN:R07476] Coenzyme M biosynthesis Energy C1 0 0 -K05979 2-phosphosulfolactate phosphatase [EC:3.1.3.71] [RN:R05789] Coenzyme M biosynthesis Energy C1 0 0 -K05884 L-2-hydroxycarboxylate dehydrogenase (NAD+) [EC:1.1.1.337] [RN:R07136] Coenzyme M biosynthesis Energy C1 0 0 -K13039 sulfopyruvate decarboxylase [EC:4.1.1.79] [RN:R05774] Coenzyme M biosynthesis Energy C1 0 0 -K06034 sulfopyruvate decarboxylase [EC:4.1.1.79] [RN:R05774] Coenzyme M biosynthesis Energy C1 0 0 -K00169 pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K00170 pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K00171 pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K00172 pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K01007 pyruvate, water dikinase [EC:2.7.9.2] [RN:R00199] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K01595 phosphoenolpyruvate carboxylase [EC:4.1.1.31] [RN:R00345] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K00024 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K01676 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K01677 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K01678 fumarate hydratase [EC:4.2.1.2] [RN:R01082] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K00239 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K00240 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K00241 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K18860 succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K01902 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K01903 succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K15038 succinyl-CoA reductase [EC:1.2.1.76] [RN:R09280] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K15017 succinyl-CoA reductase [EC:1.2.1.76] [RN:R09280] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K14465 succinate semialdehyde reductase (NADPH) [EC:1.1.1.-] [RN:R09281] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K14467 4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K18861 4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K14534 4-hydroxybutyryl-CoA dehydratase [EC:4.2.1.120] [RN:R10782] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K15016 3-hydroxybutyryl-CoA dehydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238] Dicarboxylate-hydroxybutyrate cycle Energy C1 0 0 -K01964 acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] [RN:R00742 R01859] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K15037 biotin carboxyl carrier protein [RN:R00742 R01859] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K15036 acetyl-CoA/propionyl-CoA carboxylase [EC:6.4.1.2 6.4.1.3] [RN:R00742 R01859] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K15017 malonyl-CoA reductase (NADPH) [EC:1.2.1.75] [RN:R00740] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K15039 3-hydroxypropionate dehydrogenase (NADP+) [EC:1.1.1.298] [RN:R09289] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K15018 3-hydroxypropionyl-coenzyme A synthetase [EC:6.2.1.36] [RN:R09286] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K15019 3-hydroxypropionyl-coenzyme A dehydratase [EC:4.2.1.116] [RN:R03045] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K15020 acryloyl-coenzyme A reductase [EC:1.3.1.84] [RN:R00919] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K05606 methylmalonyl-CoA epimerase [EC:5.1.99.1] [RN:R02765] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K01848 methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K01849 methylmalonyl-CoA mutase [EC:5.4.99.2] [RN:R00833] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K15038 succinyl-coA reductase [EC:1.2.1.76] [RN:R09280] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K14465 succinate semialdehyde reductase [EC:1.1.1.-] [RN:R09281] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K14466 4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K18861 4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K14534 4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3] [RN:R10782] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K15016 3-hydroxybutyryl-CoA dehydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K00626 acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238] Hydroxypropionate-hydroxybutylate cycle Energy C1 0 0 -K08691 malyl-CoA/(S)-citramalyl-CoA lyase [EC:4.1.3.24 4.1.3.25] [RN:R00473 R00934 R00237] 3-Hydroxypropionate bi-cycle Energy C1 0 0 -K14449 2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [RN:R05076] 3-Hydroxypropionate bi-cycle Energy C1 0 0 -K14470 2-methylfumaryl-CoA isomerase [EC:5.4.1.3] [RN:R09283] 3-Hydroxypropionate bi-cycle Energy C1 0 0 -K09709 3-methylfumaryl-CoA hydratase [EC:4.2.1.153] [RN:R09282] 3-Hydroxypropionate bi-cycle Energy C1 0 0 -K00198 carbon-monoxide dehydrogenase [EC:1.2.7.4] [RN:R07157] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K05299 formate dehydrogenase [EC:1.17.1.10] [RN:R00134] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K15022 formate dehydrogenase [EC:1.17.1.10] [RN:R00134] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K01938 formate--tetrahydrofolate ligase [EC:6.3.4.3] [RN:R00943] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K01491 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] [RN:R01655 R01220] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K00297 methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] [RN:R07168] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K15023 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase [EC:2.1.1.258] [RN:R02289] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K14138 acetyl-CoA synthase [EC:2.3.1.169] [RN:R08433] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K00197 acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R10243] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K00194 acetyl-CoA decarbonylase/synthase complex [EC:2.3.1.-] [RN:R10243] Reductive acetyl-CoA pathway (Wood-Ljungdahl pathway) Energy C1 0 0 -K11212 LPPG:FO 2-phospho-L-lactate transferase [EC:2.7.8.28] [RN:R09398] F420 biosynthesis Energy C1 0 0 -K12234 coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34] [RN:R09399 R09400] F420 biosynthesis Energy C1 0 0 -K00192 cdhA; anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit alpha [EC:1.2.7.4] [RN:R07157] Acetyl-CoA pathway, CO2 => acetyl-CoA Energy C1 0 0 -K00195 cdhB; anaerobic carbon-monoxide dehydrogenase, CODH/ACS complex subunit epsilon [RN:R07157] Acetyl-CoA pathway, CO2 => acetyl-CoA Energy C1 0 0 -K00193 cdhC; acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit beta [EC:2.3.1.169] [RN:R09096 R10219] Acetyl-CoA pathway, CO2 => acetyl-CoA Energy C1 0 0 -K00197 cdhE; acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit gamma [EC:2.1.1.245] [RN:R09096 R10219] Acetyl-CoA pathway, CO2 => acetyl-CoA Energy C1 0 0 -K00194 cdhD; acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit delta [EC:2.1.1.245] [RN:R09096 R10219] Acetyl-CoA pathway, CO2 => acetyl-CoA Energy C1 0 0 -K00196 carbon-monoxide dehydrogenase iron sulfur subunit Acetyl-CoA pathway Energy C1 0 0 -K03518 carbon-monoxide dehydrogenase small subunit Acetyl-CoA pathway Energy C1 0 0 -K03519 carbon-monoxide dehydrogenase medium subunit Acetyl-CoA pathway Energy C1 0 0 -K03520 carbon-monoxide dehydrogenase large subunit Acetyl-CoA pathway Energy C1 0 0 -K02981 small subunit ribosomal protein S2e Ribosome, eukaryotes MISC Information systems 0 0 -K02985 small subunit ribosomal protein S3e Ribosome, eukaryotes MISC Information systems 0 0 -K02984 small subunit ribosomal protein S3Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02987 small subunit ribosomal protein S4e Ribosome, eukaryotes MISC Information systems 0 0 -K02989 small subunit ribosomal protein S5e Ribosome, eukaryotes MISC Information systems 0 0 -K02991 small subunit ribosomal protein S6e Ribosome, eukaryotes MISC Information systems 0 0 -K02993 small subunit ribosomal protein S7e Ribosome, eukaryotes MISC Information systems 0 0 -K02995 small subunit ribosomal protein S8e Ribosome, eukaryotes MISC Information systems 0 0 -K02997 small subunit ribosomal protein S9e Ribosome, eukaryotes MISC Information systems 0 0 -K02947 small subunit ribosomal protein S10e Ribosome, eukaryotes MISC Information systems 0 0 -K02949 small subunit ribosomal protein S11e Ribosome, eukaryotes MISC Information systems 0 0 -K02951 small subunit ribosomal protein S12e Ribosome, eukaryotes MISC Information systems 0 0 -K02953 small subunit ribosomal protein S13e Ribosome, eukaryotes MISC Information systems 0 0 -K02955 small subunit ribosomal protein S14e Ribosome, eukaryotes MISC Information systems 0 0 -K02958 small subunit ribosomal protein S15e Ribosome, eukaryotes MISC Information systems 0 0 -K02957 small subunit ribosomal protein S15Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02960 small subunit ribosomal protein S16e Ribosome, eukaryotes MISC Information systems 0 0 -K02962 small subunit ribosomal protein S17e Ribosome, eukaryotes MISC Information systems 0 0 -K02964 small subunit ribosomal protein S18e Ribosome, eukaryotes MISC Information systems 0 0 -K02966 small subunit ribosomal protein S19e Ribosome, eukaryotes MISC Information systems 0 0 -K02969 small subunit ribosomal protein S20e Ribosome, eukaryotes MISC Information systems 0 0 -K02971 small subunit ribosomal protein S21e Ribosome, eukaryotes MISC Information systems 0 0 -K02973 small subunit ribosomal protein S23e Ribosome, eukaryotes MISC Information systems 0 0 -K02974 small subunit ribosomal protein S24e Ribosome, eukaryotes MISC Information systems 0 0 -K02975 small subunit ribosomal protein S25e Ribosome, eukaryotes MISC Information systems 0 0 -K02976 small subunit ribosomal protein S26e Ribosome, eukaryotes MISC Information systems 0 0 -K02978 small subunit ribosomal protein S27e Ribosome, eukaryotes MISC Information systems 0 0 -K02977 small subunit ribosomal protein S27Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02979 small subunit ribosomal protein S28e Ribosome, eukaryotes MISC Information systems 0 0 -K02980 small subunit ribosomal protein S29e Ribosome, eukaryotes MISC Information systems 0 0 -K02983 small subunit ribosomal protein S30e Ribosome, eukaryotes MISC Information systems 0 0 -K02998 small subunit ribosomal protein SAe Ribosome, eukaryotes MISC Information systems 0 0 -K02925 large subunit ribosomal protein L3e Ribosome, eukaryotes MISC Information systems 0 0 -K02930 large subunit ribosomal protein L4e Ribosome, eukaryotes MISC Information systems 0 0 -K02932 large subunit ribosomal protein L5e Ribosome, eukaryotes MISC Information systems 0 0 -K02934 large subunit ribosomal protein L6e Ribosome, eukaryotes MISC Information systems 0 0 -K02937 large subunit ribosomal protein L7e Ribosome, eukaryotes MISC Information systems 0 0 -K02936 large subunit ribosomal protein L7Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02938 large subunit ribosomal protein L8e Ribosome, eukaryotes MISC Information systems 0 0 -K02940 large subunit ribosomal protein L9e Ribosome, eukaryotes MISC Information systems 0 0 -K02866 large subunit ribosomal protein L10e Ribosome, eukaryotes MISC Information systems 0 0 -K02865 large subunit ribosomal protein L10Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02868 large subunit ribosomal protein L11e Ribosome, eukaryotes MISC Information systems 0 0 -K02870 large subunit ribosomal protein L12e Ribosome, eukaryotes MISC Information systems 0 0 -K02873 large subunit ribosomal protein L13e Ribosome, eukaryotes MISC Information systems 0 0 -K02872 large subunit ribosomal protein L13Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02875 large subunit ribosomal protein L14e Ribosome, eukaryotes MISC Information systems 0 0 -K02877 large subunit ribosomal protein L15e Ribosome, eukaryotes MISC Information systems 0 0 -K02880 large subunit ribosomal protein L17e Ribosome, eukaryotes MISC Information systems 0 0 -K02883 large subunit ribosomal protein L18e Ribosome, eukaryotes MISC Information systems 0 0 -K02882 large subunit ribosomal protein L18Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02885 large subunit ribosomal protein L19e Ribosome, eukaryotes MISC Information systems 0 0 -K02889 large subunit ribosomal protein L21e Ribosome, eukaryotes MISC Information systems 0 0 -K02891 large subunit ribosomal protein L22e Ribosome, eukaryotes MISC Information systems 0 0 -K02894 large subunit ribosomal protein L23e Ribosome, eukaryotes MISC Information systems 0 0 -K02893 large subunit ribosomal protein L23Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02896 large subunit ribosomal protein L24e Ribosome, eukaryotes MISC Information systems 0 0 -K02898 large subunit ribosomal protein L26e Ribosome, eukaryotes MISC Information systems 0 0 -K02901 large subunit ribosomal protein L27e Ribosome, eukaryotes MISC Information systems 0 0 -K02900 large subunit ribosomal protein L27Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02903 large subunit ribosomal protein L28e Ribosome, eukaryotes MISC Information systems 0 0 -K02905 large subunit ribosomal protein L29e Ribosome, eukaryotes MISC Information systems 0 0 -K02908 large subunit ribosomal protein L30e Ribosome, eukaryotes MISC Information systems 0 0 -K02910 large subunit ribosomal protein L31e Ribosome, eukaryotes MISC Information systems 0 0 -K02912 large subunit ribosomal protein L32e Ribosome, eukaryotes MISC Information systems 0 0 -K02915 large subunit ribosomal protein L34e Ribosome, eukaryotes MISC Information systems 0 0 -K02918 large subunit ribosomal protein L35e Ribosome, eukaryotes MISC Information systems 0 0 -K02917 large subunit ribosomal protein L35Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02920 large subunit ribosomal protein L36e Ribosome, eukaryotes MISC Information systems 0 0 -K02922 large subunit ribosomal protein L37e Ribosome, eukaryotes MISC Information systems 0 0 -K02921 large subunit ribosomal protein L37Ae Ribosome, eukaryotes MISC Information systems 0 0 -K02923 large subunit ribosomal protein L38e Ribosome, eukaryotes MISC Information systems 0 0 -K02924 large subunit ribosomal protein L39e Ribosome, eukaryotes MISC Information systems 0 0 -K02927 large subunit ribosomal protein L40e Ribosome, eukaryotes MISC Information systems 0 0 -K02928 large subunit ribosomal protein L41e Ribosome, eukaryotes MISC Information systems 0 0 -K02929 large subunit ribosomal protein L44e Ribosome, eukaryotes MISC Information systems 0 0 -K02941 large subunit ribosomal protein LP0 Ribosome, eukaryotes MISC Information systems 0 0 -K02942 large subunit ribosomal protein LP1 Ribosome, eukaryotes MISC Information systems 0 0 -K02943 large subunit ribosomal protein LP2 Ribosome, eukaryotes MISC Information systems 0 0 -K02946 small subunit ribosomal protein S10 Ribosome, bacteria MISC Information systems 0 0 -K02906 large subunit ribosomal protein L3 Ribosome, bacteria MISC Information systems 0 0 -K02926 large subunit ribosomal protein L4 Ribosome, bacteria MISC Information systems 0 0 -K02892 large subunit ribosomal protein L23 Ribosome, bacteria MISC Information systems 0 0 -K02886 large subunit ribosomal protein L2 Ribosome, bacteria MISC Information systems 0 0 -K02965 small subunit ribosomal protein S19 Ribosome, bacteria MISC Information systems 0 0 -K02890 large subunit ribosomal protein L22 Ribosome, bacteria MISC Information systems 0 0 -K02982 small subunit ribosomal protein S3 Ribosome, bacteria MISC Information systems 0 0 -K02878 large subunit ribosomal protein L16 Ribosome, bacteria MISC Information systems 0 0 -K02904 large subunit ribosomal protein L29 Ribosome, bacteria MISC Information systems 0 0 -K02961 small subunit ribosomal protein S17 Ribosome, bacteria MISC Information systems 0 0 -K02874 large subunit ribosomal protein L14 Ribosome, bacteria MISC Information systems 0 0 -K02895 large subunit ribosomal protein L24 Ribosome, bacteria MISC Information systems 0 0 -K02931 large subunit ribosomal protein L5 Ribosome, bacteria MISC Information systems 0 0 -K02954 small subunit ribosomal protein S14 Ribosome, bacteria MISC Information systems 0 0 -K02994 small subunit ribosomal protein S8 Ribosome, bacteria MISC Information systems 0 0 -K02933 large subunit ribosomal protein L6 Ribosome, bacteria MISC Information systems 0 0 -K02881 large subunit ribosomal protein L18 Ribosome, bacteria MISC Information systems 0 0 -K02988 small subunit ribosomal protein S5 Ribosome, bacteria MISC Information systems 0 0 -K02907 large subunit ribosomal protein L30 Ribosome, bacteria MISC Information systems 0 0 -K02876 large subunit ribosomal protein L15 Ribosome, bacteria MISC Information systems 0 0 -K02919 large subunit ribosomal protein L36 Ribosome, bacteria MISC Information systems 0 0 -K02952 small subunit ribosomal protein S13 Ribosome, bacteria MISC Information systems 0 0 -K02948 small subunit ribosomal protein S11 Ribosome, bacteria MISC Information systems 0 0 -K02986 small subunit ribosomal protein S4 Ribosome, bacteria MISC Information systems 0 0 -K02879 large subunit ribosomal protein L17 Ribosome, bacteria MISC Information systems 0 0 -K02871 large subunit ribosomal protein L13 Ribosome, bacteria MISC Information systems 0 0 -K02996 small subunit ribosomal protein S9 Ribosome, bacteria MISC Information systems 0 0 -K02992 small subunit ribosomal protein S7 Ribosome, bacteria MISC Information systems 0 0 -K02950 small subunit ribosomal protein S12 Ribosome, bacteria MISC Information systems 0 0 -K07590 large subunit ribosomal protein L7A Ribosome, bacteria MISC Information systems 0 0 -K02935 large subunit ribosomal protein L7/L12 Ribosome, bacteria MISC Information systems 0 0 -K02864 large subunit ribosomal protein L10 Ribosome, bacteria MISC Information systems 0 0 -K02863 large subunit ribosomal protein L1 Ribosome, bacteria MISC Information systems 0 0 -K02867 large subunit ribosomal protein L11 Ribosome, bacteria MISC Information systems 0 0 -K02967 small subunit ribosomal protein S2 Ribosome, bacteria MISC Information systems 0 0 -K02956 small subunit ribosomal protein S15 Ribosome, bacteria MISC Information systems 0 0 -K02916 large subunit ribosomal protein L35 Ribosome, bacteria MISC Information systems 0 0 -K02887 large subunit ribosomal protein L20 Ribosome, bacteria MISC Information systems 0 0 -K02914 large subunit ribosomal protein L34 Ribosome, bacteria MISC Information systems 0 0 -K02939 large subunit ribosomal protein L9 Ribosome, bacteria MISC Information systems 0 0 -K02963 small subunit ribosomal protein S18 Ribosome, bacteria MISC Information systems 0 0 -K02990 small subunit ribosomal protein S6 Ribosome, bacteria MISC Information systems 0 0 -K02888 large subunit ribosomal protein L21 Ribosome, bacteria MISC Information systems 0 0 -K02899 large subunit ribosomal protein L27 Ribosome, bacteria MISC Information systems 0 0 -K02902 large subunit ribosomal protein L28 Ribosome, bacteria MISC Information systems 0 0 -K02913 large subunit ribosomal protein L33 Ribosome, bacteria MISC Information systems 0 0 -K02911 large subunit ribosomal protein L32 Ribosome, bacteria MISC Information systems 0 0 -K02909 large subunit ribosomal protein L31 Ribosome, bacteria MISC Information systems 0 0 -K02897 large subunit ribosomal protein L25 Ribosome, bacteria MISC Information systems 0 0 -K02959 small subunit ribosomal protein S16 Ribosome, bacteria MISC Information systems 0 0 -K02884 large subunit ribosomal protein L19 Ribosome, bacteria MISC Information systems 0 0 -K02968 small subunit ribosomal protein S20 Ribosome, bacteria MISC Information systems 0 0 -K02945 small subunit ribosomal protein S1 Ribosome, bacteria MISC Information systems 0 0 -K02970 small subunit ribosomal protein S21 Ribosome, bacteria MISC Information systems 0 0 -K02946 small subunit ribosomal protein S10 Ribosome, archaea MISC Information systems 0 0 -K02906 large subunit ribosomal protein L3 Ribosome, archaea MISC Information systems 0 0 -K02930 large subunit ribosomal protein L4e Ribosome, archaea MISC Information systems 0 0 -K02892 large subunit ribosomal protein L23 Ribosome, archaea MISC Information systems 0 0 -K02886 large subunit ribosomal protein L2 Ribosome, archaea MISC Information systems 0 0 -K02965 small subunit ribosomal protein S19 Ribosome, archaea MISC Information systems 0 0 -K02890 large subunit ribosomal protein L22 Ribosome, archaea MISC Information systems 0 0 -K02982 small subunit ribosomal protein S3 Ribosome, archaea MISC Information systems 0 0 -K02904 large subunit ribosomal protein L29 Ribosome, archaea MISC Information systems 0 0 -K02961 small subunit ribosomal protein S17 Ribosome, archaea MISC Information systems 0 0 -K02874 large subunit ribosomal protein L14 Ribosome, archaea MISC Information systems 0 0 -K02895 large subunit ribosomal protein L24 Ribosome, archaea MISC Information systems 0 0 -K02987 small subunit ribosomal protein S4e Ribosome, archaea MISC Information systems 0 0 -K02931 large subunit ribosomal protein L5 Ribosome, archaea MISC Information systems 0 0 -K02954 small subunit ribosomal protein S14 Ribosome, archaea MISC Information systems 0 0 -K02994 small subunit ribosomal protein S8 Ribosome, archaea MISC Information systems 0 0 -K02933 large subunit ribosomal protein L6 Ribosome, archaea MISC Information systems 0 0 -K02912 large subunit ribosomal protein L32e Ribosome, archaea MISC Information systems 0 0 -K02885 large subunit ribosomal protein L19e Ribosome, archaea MISC Information systems 0 0 -K02881 large subunit ribosomal protein L18 Ribosome, archaea MISC Information systems 0 0 -K02988 small subunit ribosomal protein S5 Ribosome, archaea MISC Information systems 0 0 -K02907 large subunit ribosomal protein L30 Ribosome, archaea MISC Information systems 0 0 -K02876 large subunit ribosomal protein L15 Ribosome, archaea MISC Information systems 0 0 -K02952 small subunit ribosomal protein S13 Ribosome, archaea MISC Information systems 0 0 -K02948 small subunit ribosomal protein S11 Ribosome, archaea MISC Information systems 0 0 -K02986 small subunit ribosomal protein S4 Ribosome, archaea MISC Information systems 0 0 -K02883 large subunit ribosomal protein L18e Ribosome, archaea MISC Information systems 0 0 -K02871 large subunit ribosomal protein L13 Ribosome, archaea MISC Information systems 0 0 -K02996 small subunit ribosomal protein S9 Ribosome, archaea MISC Information systems 0 0 -K02992 small subunit ribosomal protein S7 Ribosome, archaea MISC Information systems 0 0 -K02950 small subunit ribosomal protein S12 Ribosome, archaea MISC Information systems 0 0 -K02936 large subunit ribosomal protein L7Ae Ribosome, archaea MISC Information systems 0 0 -K02979 small subunit ribosomal protein S28e Ribosome, archaea MISC Information systems 0 0 -K02896 large subunit ribosomal protein L24e Ribosome, archaea MISC Information systems 0 0 -K02869 large subunit ribosomal protein L12 Ribosome, archaea MISC Information systems 0 0 -K02864 large subunit ribosomal protein L10 Ribosome, archaea MISC Information systems 0 0 -K02863 large subunit ribosomal protein L1 Ribosome, archaea MISC Information systems 0 0 -K02867 large subunit ribosomal protein L11 Ribosome, archaea MISC Information systems 0 0 -K02967 small subunit ribosomal protein S2 Ribosome, archaea MISC Information systems 0 0 -K02956 small subunit ribosomal protein S15 Ribosome, archaea MISC Information systems 0 0 -K02978 small subunit ribosomal protein S27e Ribosome, archaea MISC Information systems 0 0 -K02929 large subunit ribosomal protein L44e Ribosome, archaea MISC Information systems 0 0 -K02877 large subunit ribosomal protein L15e Ribosome, archaea MISC Information systems 0 0 -K02984 small subunit ribosomal protein S3Ae Ribosome, archaea MISC Information systems 0 0 -K02991 small subunit ribosomal protein S6e Ribosome, archaea MISC Information systems 0 0 -K02974 small subunit ribosomal protein S24e Ribosome, archaea MISC Information systems 0 0 -K02977 small subunit ribosomal protein S27Ae Ribosome, archaea MISC Information systems 0 0 -K02962 small subunit ribosomal protein S17e Ribosome, archaea MISC Information systems 0 0 -K02910 large subunit ribosomal protein L31e Ribosome, archaea MISC Information systems 0 0 -K02924 large subunit ribosomal protein L39e Ribosome, archaea MISC Information systems 0 0 -K02866 large subunit ribosomal protein L10e Ribosome, archaea MISC Information systems 0 0 -K02889 large subunit ribosomal protein L21e Ribosome, archaea MISC Information systems 0 0 -K02922 large subunit ribosomal protein L37e Ribosome, archaea MISC Information systems 0 0 -K02921 large subunit ribosomal protein L37Ae Ribosome, archaea MISC Information systems 0 0 -K02995 small subunit ribosomal protein S8e Ribosome, archaea MISC Information systems 0 0 -K02966 small subunit ribosomal protein S19e Ribosome, archaea MISC Information systems 0 0 -K02927 large subunit ribosomal protein L40e Ribosome, archaea MISC Information systems 0 0 -K02944 large subunit ribosomal protein LX Ribosome, archaea MISC Information systems 0 0 -K02976 small subunit ribosomal protein S26e Ribosome, archaea MISC Information systems 0 0 -K02975 small subunit ribosomal protein S25e Ribosome, archaea MISC Information systems 0 0 -K02983 small subunit ribosomal protein S30e Ribosome, archaea MISC Information systems 0 0 -K02873 large subunit ribosomal protein L13e Ribosome, archaea MISC Information systems 0 0 -K02917 large subunit ribosomal protein L35Ae Ribosome, archaea MISC Information systems 0 0 -K02928 large subunit ribosomal protein L41e Ribosome, archaea MISC Information systems 0 0 -K02915 large subunit ribosomal protein L34e Ribosome, archaea MISC Information systems 0 0 -K02875 large subunit ribosomal protein L14e Ribosome, archaea MISC Information systems 0 0 -K02908 large subunit ribosomal protein L30e Ribosome, archaea MISC Information systems 0 0 -K00764 amidophosphoribosyltransferase [EC:2.4.2.14] [RN:R01072] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K01945 phosphoribosylamine--glycine ligase [EC:6.3.4.13] [RN:R04144] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K11787 phosphoribosylamine--glycine ligase [EC:6.3.4.13] [RN:R04144] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K11788 phosphoribosylamine--glycine ligase [EC:6.3.4.13] [RN:R04144] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K13713 fusion protein PurCD [EC:6.3.2.6 6.3.4.13] [RN:R04144 R04591] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K00601 phosphoribosylglycinamide formyltransferase [EC:2.1.2.2] [RN:R04325] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K11175 phosphoribosylglycinamide formyltransferase [EC:2.1.2.2] [RN:R04325] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K08289 phosphoribosylglycinamide formyltransferase [EC:2.1.2.2] [RN:R04325] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K01492 phosphoribosylglycinamide formyltransferase [EC:2.1.2.2] [RN:R04325] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K01952 phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] [RN:R04463] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K01933 phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] [RN:R04208] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K01587 phosphoribosylaminoimidazole carboxylase [EC:4.1.1.21] [RN:R04209] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K11808 phosphoribosylaminoimidazole carboxylase [EC:4.1.1.21] [RN:R04209] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K01589 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18] [RN:R07405] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K01588 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] [RN:R07404] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K01923 phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] [RN:R04591] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K01756 adenylosuccinate lyase [EC:4.3.2.2] [RN:R04559] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K00602 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] [RN:R04560 R01127] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K06863 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase [EC:6.3.4.23] [RN:R06975] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K11176 IMP cyclohydrolase [EC:3.5.4.10] [RN:R01127] Inosine monophosphate biosynthesis, PRPP + glutamine => IMP MISC Information systems Nucleotide 0 0 -K00088 IMP dehydrogenase [EC:1.1.1.205] [RN:R01130] Guanine ribonucleotide biosynthesis IMP => GDP,GTP MISC Information systems Nucleotide 0 0 -K01951 GMP synthase [EC:6.3.5.2] [RN:R01230 R01231] Guanine ribonucleotide biosynthesis IMP => GDP,GTP MISC Information systems Nucleotide 0 0 -K00942 guanylate kinase [EC:2.7.4.8] [RN:R00332] Guanine ribonucleotide biosynthesis IMP => GDP,GTP MISC Information systems Nucleotide 0 0 -K00940 nucleoside-diphosphate kinase [EC:2.7.4.6] [RN:R00330] Guanine ribonucleotide biosynthesis IMP => GDP,GTP MISC Information systems Nucleotide 0 0 -K00873 pyruvate kinase [EC:2.7.1.40] [RN:R00430] Guanine ribonucleotide biosynthesis IMP => GDP,GTP MISC Information systems Nucleotide 0 0 -K12406 pyruvate kinase [EC:2.7.1.40] [RN:R00430] Guanine ribonucleotide biosynthesis IMP => GDP,GTP MISC Information systems Nucleotide 0 0 -K00844 hexokinase [EC:2.7.1.1] [RN:R01786] Nucleotide sugar biosynthesis, glucose => UDP-glucose MISC Information systems Nucleotide 0 0 -K00845 glucokinase [EC:2.7.1.2] [RN:R01786] Nucleotide sugar biosynthesis, glucose => UDP-glucose MISC Information systems Nucleotide 0 0 -K12407 glucokinase [EC:2.7.1.2] [RN:R01786] Nucleotide sugar biosynthesis, glucose => UDP-glucose MISC Information systems Nucleotide 0 0 -K00886 polyphosphate glucokinase [EC:2.7.1.63] [RN:R02189] Nucleotide sugar biosynthesis, glucose => UDP-glucose MISC Information systems Nucleotide 0 0 -K01835 phosphoglucomutase [EC:5.4.2.2] [RN:R00959] Nucleotide sugar biosynthesis, glucose => UDP-glucose MISC Information systems Nucleotide 0 0 -K00963 UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] [RN:R00289] Nucleotide sugar biosynthesis, glucose => UDP-glucose MISC Information systems Nucleotide 0 0 -K00849 galactokinase [EC:2.7.1.6] [RN:R01092] Nucleotide sugar biosynthesis, galactose => UDP-galactose MISC Information systems Nucleotide 0 0 -K00965 UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12] [RN:R00955] Nucleotide sugar biosynthesis, galactose => UDP-galactose MISC Information systems Nucleotide 0 0 -K01939 adenylosuccinate synthase [EC:6.3.4.4] [RN:R01135] Adenine ribonucleotide biosynthesis, IMP => ADP,ATP MISC Information systems Nucleotide 0 0 -K01756 adenylosuccinate lyase [EC:4.3.2.2] [RN:R01083] Adenine ribonucleotide biosynthesis, IMP => ADP,ATP MISC Information systems Nucleotide 0 0 -K00939 adenylate kinase [EC:2.7.4.3] [RN:R00127] Adenine ribonucleotide biosynthesis, IMP => ADP,ATP MISC Information systems Nucleotide 0 0 -K18532 adenylate kinase [EC:2.7.4.3] [RN:R00127] Adenine ribonucleotide biosynthesis, IMP => ADP,ATP MISC Information systems Nucleotide 0 0 -K18533 adenylate kinase [EC:2.7.4.3] [RN:R00127] Adenine ribonucleotide biosynthesis, IMP => ADP,ATP MISC Information systems Nucleotide 0 0 -K00944 nucleoside-triphosphate--adenylate kinase [EC:2.7.4.10] [RN:R00333] Adenine ribonucleotide biosynthesis, IMP => ADP,ATP MISC Information systems Nucleotide 0 0 -K00940 nucleoside-diphosphate kinase [EC:2.7.4.6] [RN:R00124] Adenine ribonucleotide biosynthesis, IMP => ADP,ATP MISC Information systems Nucleotide 0 0 -K00873 pyruvate kinase [EC:2.7.1.40] [RN:R00200] Adenine ribonucleotide biosynthesis, IMP => ADP,ATP MISC Information systems Nucleotide 0 0 -K12406 pyruvate kinase [EC:2.7.1.40] [RN:R00200] Adenine ribonucleotide biosynthesis, IMP => ADP,ATP MISC Information systems Nucleotide 0 0 -K11540 carbamoyl-phosphate synthase [EC:6.3.5.5] [RN:R00575] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K11541 carbamoyl-phosphate synthase [EC:6.3.5.5] [RN:R00575] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K01465 dihydroorotase [EC:3.5.2.3] [RN:R01993] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K01954 carbamoyl-phosphate synthase [EC:6.3.5.5] [RN:R00575] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K01955 carbamoyl-phosphate synthase [EC:6.3.5.5] [RN:R00575] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K01956 carbamoyl-phosphate synthase [EC:6.3.5.5] [RN:R00575] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K00609 aspartate carbamoyltransferase [EC:2.1.3.2] [RN:R01397] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K00610 aspartate carbamoyltransferase [EC:2.1.3.2] [RN:R01397] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K00608 aspartate carbamoyltransferase [EC:2.1.3.2] [RN:R01397] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K00226 dihydroorotate dehydrogenase [EC:1.3.98.1] [RN:R01867] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K00254 dihydroorotate dehydrogenase [EC:1.3.5.2] [RN:R01868] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K17828 dihydroorotate dehydrogenase [EC:1.3.1.14] [RN:R01869] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K13421 orotate phosphoribosyltransferase [EC:2.4.2.10] [RN:R01870] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K00762 orotate phosphoribosyltransferase [EC:2.4.2.10] [RN:R01870] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K01591 orotidine-5'-phosphate decarboxylase [EC:4.1.1.23] [RN:R00965] Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP MISC Information systems Nucleotide 0 0 -K13800 cytidylate kinase [EC:2.7.4.14] [RN:R00158] Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP MISC Information systems Nucleotide 0 0 -K13809 cytidylate kinase [EC:2.7.4.14] [RN:R00158] Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP MISC Information systems Nucleotide 0 0 -K00945 cytidylate kinase [EC:2.7.4.14] [RN:R00158] Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP MISC Information systems Nucleotide 0 0 -K13799 cytidylate kinase [EC:2.7.4.14] [RN:R00158] Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP MISC Information systems Nucleotide 0 0 -K00940 nucleoside-diphosphate kinase [EC:2.7.4.6] [RN:R00156] Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP MISC Information systems Nucleotide 0 0 -K18533 nucleoside-diphosphate kinase [EC:2.7.4.6] [RN:R00156] Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP MISC Information systems Nucleotide 0 0 -K01937 CTP synthase [EC:6.3.4.2] [RN:R00571 R00573] Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP MISC Information systems Nucleotide 0 0 -K00524 ribonucleoside-diphosphate reductase [EC:1.17.4.1] [RN:R02024] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K00525 ribonucleoside-diphosphate reductase [EC:1.17.4.1] [RN:R02024] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K00526 ribonucleoside-diphosphate reductase [EC:1.17.4.1] [RN:R02024] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K10807 ribonucleoside-diphosphate reductase [EC:1.17.4.1] [RN:R02024] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K10808 ribonucleoside-diphosphate reductase [EC:1.17.4.1] [RN:R02024] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K00940 nucleoside-diphosphate kinase [EC:2.7.4.6] [RN:R02326 R02093] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K18533 nucleoside-diphosphate kinase [EC:2.7.4.6] [RN:R02326 R02093] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K00527 ribonucleoside-triphosphate reductase [EC:1.17.4.2 1.1.98.6] [RN:R02022 R11636] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K21636 ribonucleoside-triphosphate reductase [EC:1.17.4.2 1.1.98.6] [RN:R02022 R11636] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K01494 dCTP deaminase [EC:3.5.4.13] [RN:R02325] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K01520 dUTP pyrophosphatase [EC:3.6.1.23] [RN:R02100] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K00560 thymidylate synthase [EC:2.1.1.45] [RN:R02101] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K13998 thymidylate synthase [EC:2.1.1.45] [RN:R02101] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K00943 dTMP kinase [EC:2.7.4.9] [RN:R02094] Pyrimidine deoxyribonuleotide biosynthesis, CDP/CTP => dCDP/dCTP,dTDP/dTTP MISC Information systems Nucleotide 0 0 -K00963 UGP2; Glc-1P -> UDP-Glc [EC:2.7.7.9] Nucleotide sugar biosynthesis, eukaryotes MISC Information systems Nucleotide 0 0 -K01784 GALE; UDP-Glc -> UDP-Gal [EC:5.1.3.2] Nucleotide sugar biosynthesis, eukaryotes MISC Information systems Nucleotide 0 0 -K00972 UAP1; GlcNAc-1P -> UDP-GlcNAc [EC:2.7.7.23] Nucleotide sugar biosynthesis, eukaryotes MISC Information systems Nucleotide 0 0 -K00012 UGDH; UDP-Glc -> UDP-GlcA [EC:1.1.1.22] Nucleotide sugar biosynthesis, eukaryotes MISC Information systems Nucleotide 0 0 -K08678 UXS1; UDP-GlcA -> UDP-Xyl [EC:4.1.1.35] Nucleotide sugar biosynthesis, eukaryotes MISC Information systems Nucleotide 0 0 -K00966 GMPP; Man-1P -> GDP-Man [EC:2.7.7.13] Nucleotide sugar biosynthesis, eukaryotes MISC Information systems Nucleotide 0 0 -K00971 GMPP; Man-1P -> GDP-Man [EC:2.7.7.13] Nucleotide sugar biosynthesis, eukaryotes MISC Information systems Nucleotide 0 0 -K01661 naphthoate synthase Menaquinone biosynthesis MISC MISC 0 0 -K01851 salicylate biosynthesis isochorismate synthase Menaquinone biosynthesis MISC MISC 0 0 -K01911 O-succinylbenzoic acid--CoA ligase Menaquinone biosynthesis MISC MISC 0 0 -K02361 isochorismate synthase Menaquinone biosynthesis MISC MISC 0 0 -K02548 1,4-dihydroxy-2-naphthoate octaprenyltransferase Menaquinone biosynthesis MISC MISC 0 0 -K02549 O-succinylbenzoate synthase Menaquinone biosynthesis MISC MISC 0 0 -K02551 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase Menaquinone biosynthesis MISC MISC 0 0 -K02552 menaquinone-specific isochorismate synthase Menaquinone biosynthesis MISC MISC 0 0 -K03183 demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase Menaquinone biosynthesis MISC MISC 0 0 -K08680 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Menaquinone biosynthesis MISC MISC 0 0 -K12073 1,4-dihydroxy-2-naphthoyl-CoA hydrolase Menaquinone biosynthesis MISC MISC 0 0 -K19222 1,4-dihydroxy-2-naphthoyl-CoA hydrolase Menaquinone biosynthesis MISC MISC 0 0 -K00568 2-polyprenyl-6-hydroxyphenyl methylase / 3-demethylubiquinone-9 3-methyltransferase Ubiquinone biosynthesis MISC MISC 0 0 -K03179 4-hydroxybenzoate polyprenyltransferase Ubiquinone biosynthesis MISC MISC 0 0 -K03181 chorismate--pyruvate lyase Ubiquinone biosynthesis MISC MISC 0 0 -K03182 4-hydroxy-3-polyprenylbenzoate decarboxylase Ubiquinone biosynthesis MISC MISC 0 0 -K03183 demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase Ubiquinone biosynthesis MISC MISC 0 0 -K03184 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase Ubiquinone biosynthesis MISC MISC 0 0 -K03185 2-octaprenyl-6-methoxyphenol hydroxylase Ubiquinone biosynthesis MISC MISC 0 0 -K03186 4-hydroxy-3-polyprenylbenzoate decarboxylase Ubiquinone biosynthesis MISC MISC 0 0 -K18240 chorismate lyase / 3-hydroxybenzoate synthase Ubiquinone biosynthesis MISC MISC 0 0 -K18800 2-octaprenylphenol hydroxylase Ubiquinone biosynthesis MISC MISC 0 0 -K22225 ahbAB; siroheme decarboxylase [RN:R12000] Heme biosynthesis, archaea, siroheme => heme MISC MISC 0 0 -K22226 ahbC; 12,18-didecarboxysiroheme decarboxylase [RN:R12001] Heme biosynthesis, archaea, siroheme => heme MISC MISC 0 0 -K22227 ahbD; heme synthase [RN:R12002] Heme biosynthesis, archaea, siroheme => heme MISC MISC 0 0 -K00232 acyl-CoA oxidase [EC:1.3.3.6] [RN:R07934 R07950] beta-Oxidation, peroxisome, VLCFA MISC MISC 0 0 -K12405 (3R)-3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase 2 [EC:1.1.1.- 4.2.1.119] [RN:R07935 R07936 R07951 R07952] beta-Oxidation, peroxisome, VLCFA MISC MISC 0 0 -K07513 acetyl-CoA acyltransferase 1 [EC:2.3.1.16] [RN:R07937 R07953] beta-Oxidation, peroxisome, VLCFA MISC MISC 0 0 -K08764 sterol carrier protein 2 [EC:2.3.1.176] [RN:R07937 R07953] beta-Oxidation, peroxisome, VLCFA MISC MISC 0 0 -K10214 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase [EC:1.17.99.3] [RN:R08735 R08740] beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA MISC MISC 0 0 -K12405 (3R)-3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase [EC:1.1.1.- 4.2.1.107] [RN:R04813 R04812 R04809 R04810] beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA MISC MISC 0 0 -K08764 sterol carrier protein 2 [EC:2.3.1.176] [RN:R03719 R04811] beta-Oxidation, peroxisome, tri/dihydroxycholestanoyl-CoA => choloyl/chenodeoxycholoyl-CoA MISC MISC 0 0 -K00643 5-aminolevulinate synthase [EC:2.3.1.37] [RN:R00830] Heme biosynthesis, animals and fungi, glycine => heme MISC MISC 0 0 -K01698 porphobilinogen synthase [EC:4.2.1.24] [RN:R00036] Heme biosynthesis, animals and fungi, glycine => heme MISC MISC 0 0 -K01749 hydroxymethylbilane synthase [EC:2.5.1.61] [RN:R00084] Heme biosynthesis, animals and fungi, glycine => heme MISC MISC 0 0 -K01719 uroporphyrinogen-III synthase [EC:4.2.1.75] [RN:R03165] Heme biosynthesis, animals and fungi, glycine => heme MISC MISC 0 0 -K01599 uroporphyrinogen decarboxylase [EC:4.1.1.37] [RN:R03197] Heme biosynthesis, animals and fungi, glycine => heme MISC MISC 0 0 -K00228 coproporphyrinogen III oxidase [EC:1.3.3.3] [RN:R03220] Heme biosynthesis, animals and fungi, glycine => heme MISC MISC 0 0 -K00231 protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4] [RN:R03222] Heme biosynthesis, animals and fungi, glycine => heme MISC MISC 0 0 -K01772 protoporphyrin/coproporphyrin ferrochelatase [EC:4.99.1.1] [RN:R00310] Heme biosynthesis, animals and fungi, glycine => heme MISC MISC 0 0 -K00012 UDPglucose 6-dehydrogenase [EC:1.1.1.22] [RN:R00286] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K12447 UDP-sugar pyrophosphorylase [EC:2.7.7.64] [RN:R01381] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K16190 glucuronokinase [EC:2.7.1.43] [RN:R01476] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K00699 glucuronosyltransferase [EC:2.4.1.17] [RN:R01383] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K01195 beta-glucuronidase [EC:3.2.1.31] [RN:R01478] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K14756 beta-glucuronidase [EC:3.2.1.31] [RN:R01478] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K00002 alcohol dehydrogenase (NADP+) [EC:1.1.1.2] [RN:R01481] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K13247 L-gulonate 3-dehydrogenase [EC:1.1.1.45] [RN:R02640] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K03331 L-xylulose reductase [EC:1.1.1.10] [RN:R01904] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K05351 D-xylulose reductase [EC:1.1.1.9] [RN:R01896] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K00008 L-iditol 2-dehydrogenase [EC:1.1.1.14] [RN:R01896] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K00854 xylulokinase [EC:2.7.1.17] [RN:R01639] Glucuronate pathway (uronate pathway) MISC MISC 0 0 -K02399 flagella synthesis protein FlgN Flagellar Assembly MISC Flagellar cytoplasmic chaperone 0 0 -K02413 flagellar FliJ protein Flagellar Assembly MISC Flagellar cytoplasmic chaperone 0 0 -K02422 flagellar protein FliS Flagellar Assembly MISC Flagellar cytoplasmic chaperone 0 0 -K02423 flagellar protein FliT Flagellar Assembly MISC Flagellar cytoplasmic chaperone 0 0 -K02386 flagella basal body P-ring formation protein FlgA Flagellar Assembly MISC Flagellar cytoplasmic chaperone 0 0 -K02406 flagellin Flagellar Assembly MISC Flagella Structure 0 0 -K02407 flagellar hook-associated protein 2 Flagellar Assembly MISC Flagella Structure 0 0 -K02397 flagellar hook-associated protein 3 FlgL Flagellar Assembly MISC Flagella Structure 0 0 -K02396 flagellar hook-associated protein 1 FlgK Flagellar Assembly MISC Flagella Structure 0 0 -K02414 flagellar hook-length control protein FliK Flagellar Assembly MISC Flagella Structure 0 0 -K02389 flagellar basal-body rod modification protein FlgD Flagellar Assembly MISC Flagella Structure 0 0 -K02390 flagellar hook protein FlgE Flagellar Assembly MISC Flagella Structure 0 0 -K02391 flagellar basal-body rod protein FlgF Flagellar Assembly MISC Flagella Structure 0 0 -K02392 flagellar basal-body rod protein FlgG Flagellar Assembly MISC Flagella Structure 0 0 -K02393 flagellar L-ring protein precursor FlgH Flagellar Assembly MISC Flagella Structure 0 0 -K02394 flagellar P-ring protein precursor FlgI Flagellar Assembly MISC Flagella Structure 0 0 -K02387 flagellar basal-body rod protein FlgB Flagellar Assembly MISC Flagella Structure 0 0 -K02388 flagellar basal-body rod protein FlgC Flagellar Assembly MISC Flagella Structure 0 0 -K02408 flagellar hook-basal body complex protein FliE Flagellar Assembly MISC Flagella Structure 0 0 -K02409 flagellar M-ring protein FliF Flagellar Assembly MISC Flagella Structure 0 0 -K02410 flagellar motor switch protein FliG Flagellar Assembly MISC Flagella Structure 0 0 -K02416 flagellar motor switch protein FliM Flagellar Assembly MISC Flagella Structure 0 0 -K02417 flagellar motor switch protein FliN/FliY Flagellar Assembly MISC Flagella Structure 0 0 -K02400 flagellar biosynthesis protein FlhA Flagellar Assembly MISC Flagella Structure 0 0 -K02401 flagellar biosynthetic protein FlhB Flagellar Assembly MISC Flagella Structure 0 0 -K02411 flagellar assembly protein FliH Flagellar Assembly MISC Flagella Structure 0 0 -K02412 flagellum-specific ATP synthase [EC:7.4.2.8] Flagellar Assembly MISC Flagella Structure 0 0 -K02418 flagellar protein FliO/FliZ Flagellar Assembly MISC Flagella Structure 0 0 -K02419 flagellar biosynthetic protein FliP Flagellar Assembly MISC Flagella Structure 0 0 -K02420 flagellar biosynthetic protein FliQ Flagellar Assembly MISC Flagella Structure 0 0 -K02421 flagellar biosynthetic protein FliR Flagellar Assembly MISC Flagella Structure 0 0 -K13820 flagellar biosynthetic protein FliR/FlhB Flagellar Assembly MISC Flagella Structure 0 0 -K02556 chemotaxis protein MotA Flagellar Assembly MISC Flagella Structure 0 0 -K02557 chemotaxis protein MotB Flagellar Assembly MISC Flagella Structure 0 0 -K21217 sodium-type polar flagellar protein MotX Flagellar Assembly MISC Flagella Structure 0 0 -K21218 sodium-type flagellar protein MotY Flagellar Assembly MISC Flagella Structure 0 0 -K10616 cymAa; p-cymene methyl-monooxygenase [EC:1.14.15.25] [RN:R05266] Cymene degradation, p-cymene => p-cumate MISC hydrocarbon degradation 0 0 -K18293 cymAb; p-cymene methyl-monooxygenase electron transfer component [EC:1.18.1.3] Cymene degradation, p-cymene => p-cumate MISC hydrocarbon degradation 0 0 -K10617 cymB; p-cumic alcohol dehydrogenase [RN:R05232] Cymene degradation, p-cymene => p-cumate MISC hydrocarbon degradation 0 0 -K10618 cymC; p-cumic aldehyde dehydrogenase [RN:R05235] Cymene degradation, p-cymene => p-cumate MISC hydrocarbon degradation 0 0 -K01885 glutamyl-tRNA synthetase [EC:6.1.1.17] [RN:R05578] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K14163 glutamyl-tRNA synthetase [EC:6.1.1.17] [RN:R05578] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K02492 glutamyl-tRNA reductase [EC:1.2.1.70] [RN:R04109] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K01845 glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8] [RN:R02272] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K01698 porphobilinogen synthase [EC:4.2.1.24] [RN:R00036] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K01749 hydroxymethylbilane synthase [EC:2.5.1.61] [RN:R00084] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K01719 uroporphyrinogen-III synthase [EC:4.2.1.75] [RN:R03165] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K13542 uroporphyrinogen-III synthase [EC:4.2.1.75] [RN:R03165] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K13543 uroporphyrinogen-III synthase [EC:4.2.1.75] [RN:R03165] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K02302 uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [RN:R03194] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K00589 uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [RN:R03194] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K02303 uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [RN:R03194] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K02496 uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [RN:R03194] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K02304 precorrin-2 dehydrogenase [EC:1.3.1.76] [RN:R03947] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K03794 sirohydrochlorin ferrochelatase [EC:4.99.1.4] [RN:R02864] Siroheme biosynthesis, glutamate => siroheme MISC Antibiotic Resistance 0 0 -K05599 anthranilate 1,2-dioxygenase [EC:1.14.12.1] [RN:R00823 R00825] Anthranilate degradation, anthranilate => catechol MISC hydrocarbon degradation 0 0 -K05600 anthranilate 1,2-dioxygenase [EC:1.14.12.1] [RN:R00823 R00825] Anthranilate degradation, anthranilate => catechol MISC hydrocarbon degradation 0 0 -K11311 anthranilate 1,2-dioxygenase [EC:1.14.12.1] [RN:R00823 R00825] Anthranilate degradation, anthranilate => catechol MISC hydrocarbon degradation 0 0 -K16319 anthranilate 1,2-dioxygenase [EC:1.14.12.1] Anthranilate degradation, anthranilate => catechol MISC hydrocarbon degradation 0 0 -K16320 anthranilate 1,2-dioxygenase [EC:1.14.12.1] Anthranilate degradation, anthranilate => catechol MISC hydrocarbon degradation 0 0 -K18248 anthranilate 1,2-dioxygenase [EC:1.14.12.1] Anthranilate degradation, anthranilate => catechol MISC hydrocarbon degradation 0 0 -K18249 anthranilate 1,2-dioxygenase [EC:1.14.12.1] Anthranilate degradation, anthranilate => catechol MISC hydrocarbon degradation 0 0 -K18242 salicylate 5-hydroxylase [EC:1.14.13.172] [RN:R07709 R07710] Salicylate degradation, salicylate => gentisate MISC hydrocarbon degradation 0 0 -K18243 salicylate 5-hydroxylase [EC:1.14.13.172] [RN:R07709 R07710] Salicylate degradation, salicylate => gentisate MISC hydrocarbon degradation 0 0 -K14578 salicylate 5-hydroxylase [EC:1.14.13.172] [RN:R07709 R07710] Salicylate degradation, salicylate => gentisate MISC hydrocarbon degradation 0 0 -K14581 salicylate 5-hydroxylase [EC:1.14.13.172] [RN:R07709 R07710] Salicylate degradation, salicylate => gentisate MISC hydrocarbon degradation 0 0 -K02302 cysG; uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:2.1.1.107 1.3.1.76 4.99.1.4] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K02304 MET8; precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K02190 cbiK; sirohydrochlorin cobaltochelatase [EC:4.99.1.3] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K03795 cbiX; sirohydrochlorin cobaltochelatase [EC:4.99.1.3] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K22011 cfbA; sirohydrochlorin cobalto/nickelchelatase [EC:4.99.1.3 4.99.1.11] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K03394 cobI-cbiL; precorrin-2/cobalt-factor-2 C20-methyltransferase [EC:2.1.1.130 2.1.1.151] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K13540 cobIJ; precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase [EC:2.1.1.130 2.1.1.131] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K05934 E2.1.1.131, cobJ, cbiH; precorrin-3B C17-methyltransferase [EC:2.1.1.131] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K13540 cobIJ; precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase [EC:2.1.1.130 2.1.1.131] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K13541 cbiGH-cobJ; cobalt-precorrin 5A hydrolase / precorrin-3B C17-methyltransferase [EC:3.7.1.12 2.1.1.131] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K21479 cbiH60; cobalt-factor III methyltransferase [EC:2.1.1.272] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K05936 cobM, cbiF; precorrin-4/cobalt-precorrin-4 C11-methyltransferase [EC:2.1.1.133 2.1.1.271] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K02189 cbiG; cobalt-precorrin 5A hydrolase [EC:3.7.1.12] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K13541 cbiGH-cobJ; cobalt-precorrin 5A hydrolase / precorrin-3B C17-methyltransferase [EC:3.7.1.12 2.1.1.131] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K02188 cbiD; cobalt-precorrin-5B (C1)-methyltransferase [EC:2.1.1.195] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K05895 cobK-cbiJ; precorrin-6A/cobalt-precorrin-6A reductase [EC:1.3.1.54 1.3.1.106] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K02191 cbiT; cobalt-precorrin-6B (C15)-methyltransferase [EC:2.1.1.196] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K03399 cbiE; cobalt-precorrin-7 (C5)-methyltransferase [EC:2.1.1.289] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K06042 cobH-cbiC; precorrin-8X/cobalt-precorrin-8 methylmutase [EC:5.4.99.61 5.4.99.60] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K02224 cobB-cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9 6.3.5.11] Cobalamin biosynthesis, precorrin2 => cobinamide MISC anaerobic corrin ring synthesis 0 0 -K03394 cobI-cbiL; precorrin-2/cobalt-factor-2 C20-methyltransferase [EC:2.1.1.130 2.1.1.151] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K13540 cobIJ; precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase [EC:2.1.1.130 2.1.1.131] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K02229 cobG; precorrin-3B synthase [EC:1.14.13.83] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K13540 cobIJ; precorrin-2 C20-methyltransferase / precorrin-3B C17-methyltransferase [EC:2.1.1.130 2.1.1.131] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K05934 E2.1.1.131, cobJ, cbiH; precorrin-3B C17-methyltransferase [EC:2.1.1.131] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K13541 cbiGH-cobJ; cobalt-precorrin 5A hydrolase / precorrin-3B C17-methyltransferase [EC:3.7.1.12 2.1.1.131] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K05936 cobM, cbiF; precorrin-4/cobalt-precorrin-4 C11-methyltransferase [EC:2.1.1.133 2.1.1.271] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K02228 cobF; precorrin-6A synthase [EC:2.1.1.152] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K05895 cobK-cbiJ; precorrin-6A/cobalt-precorrin-6A reductase [EC:1.3.1.54 1.3.1.106] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K00595 cobL; precorrin-6Y C5,15-methyltransferase (decarboxylating) [EC:2.1.1.132] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K06042 cobH-cbiC; precorrin-8X/cobalt-precorrin-8 methylmutase [EC:5.4.99.61 5.4.99.60] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K02224 cobB-cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9 6.3.5.11] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K02230 cobN; cobaltochelatase CobN [EC:6.6.1.2] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K09882 cobS; cobaltochelatase CobS [EC:6.6.1.2] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K09883 cobT; cobaltochelatase CobT [EC:6.6.1.2] Cobalamin biosynthesis, precorrin2 => cobinamide MISC aerobic corrin ring synthesis 0 0 -K13786 cobR; cob(II)yrinic acid a,c-diamide reductase [EC:1.16.8.1] Cobalamin biosynthesis, precorrin2 => cobinamide MISC ADO-CBL synthesis 0 0 -K00798 MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K19221 cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02232 cobQ, cbiP; adenosylcobyric acid synthase [EC:6.3.5.10] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02225 cobC1, cobC; cobalamin biosynthetic protein Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02227 cbiB, cobD; adenosylcobinamide-phosphate synthase [EC:6.3.1.10] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02227 cbiB, cobD; adenosylcobinamide-phosphate synthase [EC:6.3.1.10] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02231 cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K19712 cobY; adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.7.62] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02233 E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K13786 cobR; cob(II)yrinic acid a,c-diamide reductase [EC:1.16.8.1] Cobalamin biosynthesis, precorrin2 => cobinamide MISC ADO-CBL synthesis 0 0 -K00798 MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K19221 cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02232 cobQ, cbiP; adenosylcobyric acid synthase [EC:6.3.5.10] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02225 cobC1, cobC; cobalamin biosynthetic protein CobC Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02227 cbiB, cobD; adenosylcobinamide-phosphate synthase [EC:6.3.1.10] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02231 cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02231 cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K19712 cobY; adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.7.62] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K02233 E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26] Cobalamin biosynthesis, cobinamide => cobalamin MISC ADO-CBL synthesis 0 0 -K07016 csm1, cas10; CRISPR-associated protein Csm1 Type III signiture cas proteins MISC CRISPR Type III CRISPR-Cas system 0 0 -K19138 csm2; CRISPR-associated protein Csm2 Subtype III-A factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K09002 csm3; CRISPR-associated protein Csm3 Subtype III-A factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K19139 csm4; CRISPR-associated protein Csm4 Subtype III-A factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K19140 csm5; CRISPR-associated protein Csm5 Subtype III-A factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K07061 cmr1; CRISPR-associated protein Cmr1 Subtype III-B factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K19076 cmr2, cas10; CRISPR-associated protein Cmr2 Subtype III-B factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K09127 cmr3; CRISPR-associated protein Cmr3 Subtype III-B factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K09000 cmr4; CRISPR-associated protein Cmr4 Subtype III-B factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K19141 cmr5; CRISPR-associated protein Cmr5 Subtype III-B factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K19142 cmr6; CRISPR-associated protein Cmr6 Subtype III-B factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K19143 csx1; CRISPR-associated protein Csx1 Subtype III-U factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K19144 csx3; CRISPR-associated protein Csx3 Subtype III-U factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K19145 csx16; CRISPR-associated protein Csx16 Subtype III-U factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K19146 csaX; CRISPR-associated protein CsaX Subtype III-U factors MISC CRISPR Type III CRISPR-Cas system 0 0 -K09952 csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-] Type II signiture cas proteins MISC CRISPR Type II CRISPR-Cas system 0 0 -K19137 csn2; CRISPR-associated protein Csn2 Subtype II-A factors MISC CRISPR Type II CRISPR-Cas system 0 0 -K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] Subtype II-B factors MISC CRISPR Type II CRISPR-Cas system 0 0 -K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-] Type I signiture cas proteins MISC CRISPR Type I CRISPR-Cas system 0 0 -K07475 cas3; CRISPR-associated endonuclease Cas3-HD [EC:3.1.-.-] Type I signiture cas proteins MISC CRISPR Type I CRISPR-Cas system 0 0 -K19085 csa1; CRISPR-associated protein Csa1 Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19074 csa2; CRISPR-associated protein Csa2 Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K07725 csa3; CRISPR-associated protein Csa3 Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19086 csa4, cas8a2; CRISPR-associated protein Csa4 Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19087 csa5; CRISPR-associated protein Csa5 Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19088 cst1, cas8a; CRISPR-associated protein Cst1 Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19075 cst2, cas7; CRISPR-associated protein Cst2 Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19089 cas5a_b_c; CRISPR-associated protein Cas5a/b/c Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19090 cas5t; CRISPR-associated protein Cas5t Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-] Subtype I-A factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19114 csh1; CRISPR-associated protein Csh1 Subtype I-B factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19115 csh2; CRISPR-associated protein Csh2 Subtype I-B factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] Subtype I-B factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19116 cas5h; CRISPR-associated protein Cas5h Subtype I-B factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19117 csd1, cas8c; CRISPR-associated protein Csd1 Subtype I-C factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19118 csd2, cas7; CRISPR-associated protein Csd2 Subtype I-C factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] Subtype I-C factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19119 cas5d; CRISPR-associated protein Cas5d Subtype I-C factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19120 csc1; CRISPR-associated protein Csc1 Subtype I-D factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19121 csc2; CRISPR-associated protein Csc2 Subtype I-D factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19122 csc3; CRISPR-associated protein Csc3 Subtype I-D factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] Subtype I-D factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-] Subtype I-D factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19123 casA, cse1; CRISPR system Cascade subunit CasA Subtype I-E factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19046 casB, cse2; CRISPR system Cascade subunit CasB Subtype I-E factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19124 casC, cse4; CRISPR system Cascade subunit CasC Subtype I-E factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19125 casD, cse5; CRISPR system Cascade subunit CasD Subtype I-E factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19126 casE, cse3; CRISPR system Cascade subunit CasE Subtype I-E factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19127 csy1; CRISPR-associated protein Csy1 Subtype I-F factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19128 csy2; CRISPR-associated protein Csy2 Subtype I-F factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19129 csy3; CRISPR-associated protein Csy3 Subtype I-F factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19130 csy4, cas6f; CRISPR-associated endonuclease Csy4 [EC:3.1.-.-] Subtype I-F factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19131 csb1; CRISPR-associated protein Csb1 Subtype I-U factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19132 csb2; CRISPR-associated protein Csb2 Subtype I-U factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19133 csb3; CRISPR-associated protein Csb3 Subtype I-U factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19134 csx10; CRISPR-associated protein Csx10 Subtype I-U factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19135 csx14; CRISPR-associated protein Csx14 Subtype I-U factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K19136 csx17; CRISPR-associated protein Csx17 Subtype I-U factors MISC CRISPR Type I CRISPR-Cas system 0 0 -K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K22503 DARS; aspartyl-tRNA synthetase [EC:6.1.1.12] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K14163 EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15] Aminoacyl-tRNA biosynthesis, eukaryotes MISC Information systems 0 0 -K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6] RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6] RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03013 RPB5; DNA-directed RNA polymerases I, II, and III subunit RPABC1 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03014 RPB6; DNA-directed RNA polymerases I, II, and III subunit RPABC2 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03016 RPB8; DNA-directed RNA polymerases I, II, and III subunit RPABC3 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03009 RPB12; DNA-directed RNA polymerases I, II, and III subunit RPABC4 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03007 RPB10; DNA-directed RNA polymerases I, II, and III subunit RPABC5 RNA polymerase II, eukaryotes MISC Information systems 0 0 -K03018 RPC1; DNA-directed RNA polymerase III subunit RPC1 [EC:2.7.7.6] RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03021 RPC2; DNA-directed RNA polymerase III subunit RPC2 [EC:2.7.7.6] RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03027 RPC40; DNA-directed RNA polymerases I and III subunit RPAC1 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03020 RPC19; DNA-directed RNA polymerases I and III subunit RPAC2 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03023 RPC82; DNA-directed RNA polymerase III subunit RPC3 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03026 RPC53; DNA-directed RNA polymerase III subunit RPC4 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K14721 RPC37; DNA-directed RNA polymerase III subunit RPC5 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03025 RPC34; DNA-directed RNA polymerase III subunit RPC6 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03024 RPC31; DNA-directed RNA polymerase III subunit RPC7 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03022 RPC25; DNA-directed RNA polymerase III subunit RPC8 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03019 RPC11; DNA-directed RNA polymerase III subunit RPC10 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03013 RPB5; DNA-directed RNA polymerases I, II, and III subunit RPABC1 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03014 RPB6; DNA-directed RNA polymerases I, II, and III subunit RPABC2 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03016 RPB8; DNA-directed RNA polymerases I, II, and III subunit RPABC3 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03009 RPB12; DNA-directed RNA polymerases I, II, and III subunit RPABC4 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K03007 RPB10; DNA-directed RNA polymerases I, II, and III subunit RPABC5 RNA polymerase III, eukaryotes MISC Information systems 0 0 -K02999 RPA1; DNA-directed RNA polymerase I subunit RPA1 [EC:2.7.7.6] RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03002 RPA2; DNA-directed RNA polymerase I subunit RPA2 [EC:2.7.7.6] RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03027 RPC40; DNA-directed RNA polymerases I and III subunit RPAC1 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03020 RPC19; DNA-directed RNA polymerases I and III subunit RPAC2 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03000 RPA12; DNA-directed RNA polymerase I subunit RPA12 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03001 RPA14; DNA-directed RNA polymerase I subunit RPA14 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03003 RPA34; DNA-directed RNA polymerase I subunit RPA34 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03004 RPA43; DNA-directed RNA polymerase I subunit RPA43 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03005 RPA49; DNA-directed RNA polymerase I subunit RPA49 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03013 RPB5; DNA-directed RNA polymerases I, II, and III subunit RPABC1 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03014 RPB6; DNA-directed RNA polymerases I, II, and III subunit RPABC2 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03016 RPB8; DNA-directed RNA polymerases I, II, and III subunit RPABC3 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03009 RPB12; DNA-directed RNA polymerases I, II, and III subunit RPABC4 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03007 RPB10; DNA-directed RNA polymerases I, II, and III subunit RPABC5 RNA polymerase I, eukaryotes MISC Information systems 0 0 -K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] RNA polymerase, bacteria MISC Information systems 0 0 -K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] RNA polymerase, bacteria MISC Information systems 0 0 -K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] RNA polymerase, bacteria MISC Information systems 0 0 -K13797 rpoBC; DNA-directed RNA polymerase subunit beta-beta' [EC:2.7.7.6] RNA polymerase, bacteria MISC Information systems 0 0 -K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] RNA polymerase, bacteria MISC Information systems 0 0 -K03048 rpoE; DNA-directed RNA polymerase subunit delta RNA polymerase, bacteria MISC Information systems 0 0 -K03042 rpoA2; DNA-directed RNA polymerase subunit A [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03041 rpoA1; DNA-directed RNA polymerase subunit A' [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03044 rpoB1; DNA-directed RNA polymerase subunit B' [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03045 rpoB2; DNA-directed RNA polymerase subunit B [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K13798 rpoB; DNA-directed RNA polymerase subunit B [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03053 rpoH; DNA-directed RNA polymerase subunit H [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03055 rpoK; DNA-directed RNA polymerase subunit K [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03058 rpoN; DNA-directed RNA polymerase subunit N [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03047 rpoD; DNA-directed RNA polymerase subunit D [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03049 rpoE1; DNA-directed RNA polymerase subunit E [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03050 rpoE2; DNA-directed RNA polymerase subunit E [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03056 rpoL; DNA-directed RNA polymerase subunit L [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03059 rpoP; DNA-directed RNA polymerase subunit P [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03051 rpoF; DNA-directed RNA polymerase subunit F [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03052 rpoG; DNA-directed RNA polymerase subunit G [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K03054 rpoI; DNA-directed RNA polymerase subunit I [EC:2.7.7.6] RNA polymerase, archaea MISC Information systems 0 0 -K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K14159 rnhA-dnaQ; ribonuclease HI / DNA polymerase III subunit epsilon [EC:3.1.26.4 2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K02345 holE; DNA polymerase III subunit theta [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K02344 holD; DNA polymerase III subunit psi [EC:2.7.7.7] DNA polymerase III complex, bacteria MISC Information systems 0 0 -K02320 POLA1; DNA polymerase alpha, subunit A [EC:2.7.7.7] DNA polymerase alpha / primase complex MISC Information systems 0 0 -K02321 POLA2; DNA polymerase alpha, subunit B [EC:2.7.7.7] DNA polymerase alpha / primase complex MISC Information systems 0 0 -K02685 PRI2; DNA primase large subunit [EC:2.7.7.-] DNA polymerase alpha / primase complex MISC Information systems 0 0 -K02684 PRI1; DNA primase small subunit [EC:2.7.7.-] DNA polymerase alpha / primase complex MISC Information systems 0 0 -K02327 POLD1; DNA polymerase delta, subunit A [EC:2.7.7.7] DNA polymerase delta complex MISC Information systems 0 0 -K02328 POLD2; DNA polymerase delta, subunit B [EC:2.7.7.7] DNA polymerase delta complex MISC Information systems 0 0 -K03504 POLD3; DNA polymerase delta, subunit C [EC:2.7.7.7] DNA polymerase delta complex MISC Information systems 0 0 -K03505 POLD4; DNA polymerase delta, subunit D [EC:2.7.7.7] DNA polymerase delta complex MISC Information systems 0 0 -K02324 POLE1; DNA polymerase epsilon, subunit A [EC:2.7.7.7] DNA polymerase epsilon complex MISC Information systems 0 0 -K02325 POLE2; DNA Polymerase epsilon, subunit B [EC:2.7.7.7] DNA polymerase epsilon complex MISC Information systems 0 0 -K02326 POLE3; DNA Polymerase epsilon, subunit C [EC:2.7.7.7] DNA polymerase epsilon complex MISC Information systems 0 0 -K03506 POLE4; DNA polymerase epsilon, subunit D [EC:2.7.7.7] DNA polymerase epsilon complex MISC Information systems 0 0 -K02322 DPB1; DNA polymerase II large subunit [EC:2.7.7.7] DNA polymerase II complex, archaea MISC Information systems 0 0 -K02323 DPB2; DNA polymerase II small subunit [EC:2.7.7.7] DNA polymerase II complex, archaea MISC Information systems 0 0 -K15342 cas1; CRISP-associated protein Cas1 Universal Cas proteins MISC CRISPR 0 0 -K09951 cas2; CRISPR-associated protein Cas2 Universal Cas proteins MISC CRISPR 0 0 -A01B Catlytic type: Aspartate; residues with large hydrophobic sidechains on either side of the scissile bond, but several members have more restricted specificities that allow protein-processing functions (see additional Info); The amino acid sequences show signal peptides and propeptides except for bacterial homologues which also lack disulfide bridges and are probably cytoplasmic (Rawlings & Bateman, 2009). Many three-dimensional structures have been described. The catalytic site is located between the two lobes of the molecules, and a 'flap' structure containing a conserved Tyr residue controls specificity (James, 2004; Hong & Tang, 2004). Several of the peptidases are glycosylated (e.g. cathepsin D, A01.009) and a few are membrane-bound (memapsin-1 and memapsin-2, A01.041 and A01.004, respectively). Some family A1 peptidases from plants (e.g. phytepsin, A01.020) contain inserted saposin-like sequences, and the effects of these on enzymatic activity have been investigated (Payie et al., 2003). The secreted proteins in subfamily A usually have three conserved disulfide bridges, whereas in subfamily B there are six, and the unusual stability of nepenthesin (A01.040) to a wide pH range has been attributed to these disulfide bridges (Takahashi et al., 2005). Endopeptidases (most of which are most active at acidic pH) Organic Nitrogen Peptidase 0 0 -A01A Catlytic type: Aspartate; residues with large hydrophobic sidechains on either side of the scissile bond, but several members have more restricted specificities that allow protein-processing functions (see additional Info); The amino acid sequences show signal peptides and propeptides except for bacterial homologues which also lack disulfide bridges and are probably cytoplasmic (Rawlings & Bateman, 2009). Many three-dimensional structures have been described. The catalytic site is located between the two lobes of the molecules, and a 'flap' structure containing a conserved Tyr residue controls specificity (James, 2004; Hong & Tang, 2004). Several of the peptidases are glycosylated (e.g. cathepsin D, A01.009) and a few are membrane-bound (memapsin-1 and memapsin-2, A01.041 and A01.004, respectively). Some family A1 peptidases from plants (e.g. phytepsin, A01.020) contain inserted saposin-like sequences, and the effects of these on enzymatic activity have been investigated (Payie et al., 2003). The secreted proteins in subfamily A usually have three conserved disulfide bridges, whereas in subfamily B there are six, and the unusual stability of nepenthesin (A01.040) to a wide pH range has been attributed to these disulfide bridges (Takahashi et al., 2005). Endopeptidases (most of which are most active at acidic pH) Organic Nitrogen Peptidase 0 0 -A05 Catlytic type: Aspartate; preference for hydrophobic residues in P1 and P1; pH optimum of 2.0 and is mainly active from pH 1-5 Endopeptidase Organic Nitrogen Peptidase 0 0 -A08 Catlytic type: Aspartate; cleavage site is known as the 'lipobox sequence' and is Leu-Xaa-YaaCys in which Xaa is Ala or Ser and Yaa is Gly or Ala; essential step in the production of the bacterial cell wall Endopeptidase, the bacterial signal peptidase II Organic Nitrogen Peptidase 0 0 -A09 Catlytic type: Aspartate; processes Gag and Pol viral polyproteins in which four cleavages are made, all except one being at asparaginyl bondsour cleavages are made Endopeptidase, spumapepsin Organic Nitrogen Peptidase 0 0 -A24B Catlytic type: Aspartate; leader peptides are 5 - 8 residues long, rich in acidic amino acids, and immediately precede a 20-residue hydrophobic region; cleavage site is Gly-Phe; process type 4 pilin precursor proteins (prepilins) to their mature forms by removal of leader peptides Membrane-inserted endopeptidases Organic Nitrogen Peptidase 0 0 -A24A Catlytic type: Aspartate; leader peptides are 5 - 8 residues long, rich in acidic amino acids, and immediately precede a 20-residue hydrophobic region; cleavage site is GlyPhe; process type 4 pilin precursor proteins (prepilins) to their mature forms by removal of leader peptides Membrane-inserted endopeptidases Organic Nitrogen Peptidase 0 0 -A25 Catlytic type: Aspartate; acidic residue at P1, hydrophobic at P1, Ala at P2 and an acidic residue at P4; during the germination of spores, proteins ('small acid-soluble proteins': SASP) are degraded in a process that is initiated by the 'germination protease' A single endopeptidase Organic Nitrogen Peptidase 0 0 -A26 Catlytic type: Aspartate; cleavage between consecutive basic amino acids, but is capable of cleavage when P1 is a non-basic residue Membrane-inserted endopeptidases Organic Nitrogen Peptidase 0 0 -A28B Catlytic type: Aspartic; No peptidase activity has been shown for any member of the family No peptidase activity has been shown for any member of the family Organic Nitrogen Peptidase 0 0 -A28A Catlytic type: Aspartic; No peptidase activity has been shown for any member of the family No peptidase activity has been shown for any member of the family Organic Nitrogen Peptidase 0 0 -A31 Catlytic type: Aspartate; HycI endopeptidase releases a 32-residue C-terminal peptide by cleavage of an -Arg-Met- bond;HybD cleaves following the equivalent -His-Met- bond in hydrogenase 2, removing 15 residues; HycI and HybD are in the processing of the precursors of bacterial hydrogenases to their active forms Endopeptidases Organic Nitrogen Peptidase 0 0 -A32 Catlytic type: Aspartate; Important for processing the polar factor PodJ, which recruits proteins to the correct cell pole during cell division PerP peptidase Organic Nitrogen Peptidase 0 0 -A36 Catlytic type: Aspartate; N-terminal propeptide is removed from the sigma factor E precursor Endopeptidases Organic Nitrogen Peptidase 0 0 -A37 Catlytic type: Aspartate Pepstatin-insensitive aspartic endopeptidases Organic Nitrogen Peptidase 0 0 -C10 Catlytic type: Cysteine; broad specificity with a hydrophobic residue in the P2 position Bacterial cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -C100 Catlytic type: Cysteine; a fungal lectin and a calcium-dependent cysteine endopeptidase that is toxic to the nematodes that feed on the fungus Cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -C101 Catlytic type: Cysteine; cleaves linear ubiquitin linkages Deubiquitinases Organic Nitrogen Peptidase 0 0 -C102 Catlytic type: Cysteine; degrades the GTPase Rab proteins ; helps the pathogen to evade detection in the lysosome Cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -C106 Catlytic type: Cysteine; member is archaeosortase A (Haloferax volcanii ) archaeosortase A Organic Nitrogen Peptidase 0 0 -C11B Catlytic type: Cysteine; Selective for hydrolysis of arginyl bonds; It requires calcium ions for activity, as well as a reducing environment; member is clostripain Cysteine endopeptidase clostripain and its homologues Organic Nitrogen Peptidase 0 0 -C11A Catlytic type: Cysteine; Selective for hydrolysis of arginyl bonds; It requires calcium ions for activity, as well as a reducing environment; member is clostripain Cysteine endopeptidase clostripain and its homologues Organic Nitrogen Peptidase 0 0 -C110 Catlytic type: Cysteine Cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -C111 Catlytic type: Cysteine coagulation factor XIIIa Organic Nitrogen Peptidase 0 0 -C115 Catlytic type: Cysteine; member is MINDY-1 protein (Homo sapiens) MINDY-1 protein Organic Nitrogen Peptidase 0 0 -C116 Catlytic type: Cysteine; member is dermonecrotic toxin (Pasteurella multocida) dermonecrotic toxin Organic Nitrogen Peptidase 0 0 -C117 Catlytic type: Cysteine; member is SpvD g.p. (Salmonella enterica) SpvD gp Organic Nitrogen Peptidase 0 0 -C118 Catlytic type: Cysteine; member is EspL g.p. (Escherichia coli) EspL gp Organic Nitrogen Peptidase 0 0 -C12 Catlytic type: Cysteine; hydrolysis of bonds formed by the C-terminal Gly of ubiquitin, which may be alpha-peptide, isopeptide, amide or ester bonds; remain intracellular Ubiquitinyl hydrolases Organic Nitrogen Peptidase 0 0 -C13 Catlytic type: Cysteine; restricted specificity for asparaginyl bonds Asparaginyl endopeptidases and glycosylphosphatidylinositol:protein transamidase Organic Nitrogen Peptidase 0 0 -C15 Catlytic type: Cysteine; removal of a pyroglutamate (pGlu) residue from the N-terminus of a peptide; intracellular and soluble Omega peptidases that release an N-terminal pyroglutamate residue Organic Nitrogen Peptidase 0 0 -C25 Catlytic type: Cysteine; gingipains R and K are endopeptidases with specificity for arginyl and lysyl bonds; often secreted by the bacterium Porphyromonas gingivalis involved in periodontal disease Cysteine endopeptidases from bacteria, notably gingipain R (##C25001##) and gingipain K (##C25002##) Organic Nitrogen Peptidase 0 0 -C45 Catlytic type: Cysteine; cleavage occurs at the Gly102-Cys bond; last enzyme in the penicillin biosynthetic pathway Autolytic endopeptidases Organic Nitrogen Peptidase 0 0 -C47 Catlytic type: Cysteine; staphopains are suggested to be important for the survival of Staphylococcus sp. in vivo Endopeptidases Organic Nitrogen Peptidase 0 0 -C50 Catlytic type: Cysteine; Arg in P1 and an acidic residue in P4; there is also a preference for an acidic residue in P6 ; required for the separation of sister chromatids during mitosis in a range of organisms from yeasts to man Endopeptidases Organic Nitrogen Peptidase 0 0 -C54 Catlytic type: Cysteine; cleavage (Gly116-Arg) to release the C-terminal Arg of the protein Apg8/Aut7;it cleaves the same bond even if a peptide replaces the C-terminal Arg Endopeptidases with specificity for glycyl bonds Organic Nitrogen Peptidase 0 0 -C55 Catlytic type: Cysteine; no direct demonstration of peptidase activity of any member of family C55; responsible for certain pathogenic effects of bacteria that cause diseases in animals and plants Bacterial endopeptidases with restricted specificity Organic Nitrogen Peptidase 0 0 -C56 Catlytic type: Cysteine; acts only on peptides of less than 20 amino acids; a preference for bulky, hydrophobic P1 residues PfpI endopeptidase of {Pyrococcus furiosus} Organic Nitrogen Peptidase 0 0 -C58B Catlytic type: Cysteine; activates itself by cleaving the Lys62|+|Gly bond, and the newly exposed N-terminal Gly is then lipid-modified. Amongst other proteins, only those with a prenylated cysteine are substrates. Substrates include RhoA, the Rac and Cdc42 GTPases and host serine/threonine kinase PBS1 (which is cleaved at a single bond: <%Zhu, M. %etal, 2004[20040510A717]%>).; act as transamidases by attaching a lipid moiety to the newly exposed N-terminus of the substrate; RhoA, the Rac and Cdc42 GTPases and host serine/threonine kinase PBS1 Endopeptidases that also act as transamidases, attaching a lipid moiety to the newly exposed N-terminus of the substrate Organic Nitrogen Peptidase 0 0 -C58A Catlytic type: Cysteine; activates itself by cleaving the Lys62|+|Gly bond, and the newly exposed N-terminal Gly is then lipid-modified. Amongst other proteins, only those with a prenylated cysteine are substrates. Substrates include RhoA, the Rac and Cdc42 GTPases and host serine/threonine kinase PBS1 (which is cleaved at a single bond: <%Zhu, M. %etal, 2004[20040510A717]%>).; act as transamidases by attaching a lipid moiety to the newly exposed N-terminus of the substrate; RhoA, the Rac and Cdc42 GTPases and host serine/threonine kinase PBS1 Endopeptidases that also act as transamidases, attaching a lipid moiety to the newly exposed N-terminus of the substrate Organic Nitrogen Peptidase 0 0 -C64 Catlytic type: Cysteine; release ubiquitin from linear or branched synthetic ubiquitin chains and from ubiquitinated proteins Endoisopeptidases that release ubiquitin from ubiquitinated proteins Organic Nitrogen Peptidase 0 0 -C65 Catlytic type: Cysteine; No physiological substrates have been identified for any members of the family; No biological roles have been determined for any members of the family Isopeptidases that release ubiquitin from polyubiquitin Organic Nitrogen Peptidase 0 0 -C66 Catlytic type: Cysteine; cleaves both gamma chains of human IgG or its Fc fragment in the hinge region after Gly236 Bacterial endopeptidase Organic Nitrogen Peptidase 0 0 -C67 Catlytic type: Cysteine; de-ubiquitinating activity that is directed towards non-Lys48-linked polyubiquitin chains; involved in formation of NF-kB, which is important to inflammation response Endopeptidases that release ubiquitin from polyubiquitinated proteins Organic Nitrogen Peptidase 0 0 -C69 Catlytic type: Cysteine; cleaves Leu-Leu and Phe-Leu dipeptides with free C-terminus Dipeptidases and aminopeptidases Organic Nitrogen Peptidase 0 0 -C70 Catlytic type: Cysteine; autolytic cleavage at Gly71Gly72 and also for the elimination of the host RIN4 protein ; could contribute to the pathogenic activity of Pseudomonas syringae A putative bacterial peptidase Organic Nitrogen Peptidase 0 0 -C75 Catlytic type: Cysteine; cleaves off the C-terminus, and the N-terminus is cleaved by the signal peptidase, SpsB; contribute to the synthesis of bacterial autoinducing peptides by cleavage of precursor proteins Endopeptidases Organic Nitrogen Peptidase 0 0 -C79 Catlytic type: Cysteine; hydrolyse ubiquitinyl bonds Deubiquitinylating activity Organic Nitrogen Peptidase 0 0 -C80 Catlytic type: Cysteine; preference for Leu in P1;has been shown to be able to degrade the leucine-rich protein YopM; precursors of the cholera RTX toxin Self-cleaving proteins that are precursors of bacterial toxins Organic Nitrogen Peptidase 0 0 -C82B Catlytic type: Cysteine; hydrolyse the L-Lys(3)-D-Ala(4) bonds of bacterial cell wall components; protein showed cell-wall cross-linking activity Hydrolase (and transfer) bacterial cell wall peptides Organic Nitrogen Peptidase 0 0 -C82A Catlytic type: Cysteine; hydrolyse the L-Lys(3)-D-Ala(4) bonds of bacterial cell wall components; protein showed cell-wall cross-linking activity Hydrolase (and transfer) bacterial cell wall peptides Organic Nitrogen Peptidase 0 0 -C83 Catlytic type: Cysteine; glutathione is cleaved to gamma-Glu-Cys + Gly, either by hydrolysis or transpeptidation Exopeptidases some of which also have transferase activity Organic Nitrogen Peptidase 0 0 -C84 Catlytic type: Cysteine; hydrolyses Bz-Val-Gly-Arg-p-nitroanilide; association with periodontitis Endopeptidases Organic Nitrogen Peptidase 0 0 -C86 Catlytic type: Cysteine; deubiquitinylating activity Deubiquitinylating peptidases Organic Nitrogen Peptidase 0 0 -C88 Catlytic type: Cysteine; cleaves longer polyubiquitin chains with Lys48 linkages Deubiquitinylating enzymes Organic Nitrogen Peptidase 0 0 -C93 Catlytic type: Cysteine; member is LapG peptidase (Pseudomonas fluorescens) LapG peptidase Organic Nitrogen Peptidase 0 0 -C95 Catlytic type: Cysteine; known proteolytic activity is a processing event that is assumed to be the result of autolytic activity Self-cleaving proteins Organic Nitrogen Peptidase 0 0 -C96 Catlytic type: Cysteine; removes the leader peptide of microcin J25 Cysteine type endopeptidases Organic Nitrogen Peptidase 0 0 -C98 Catlytic type: Cysteine; release SUMO from its precursor Isopeptidases that release SUMO from conjugated proteins Organic Nitrogen Peptidase 0 0 -G01 Catlytic type: Glutamate; cleave (amongst others) the Tyr26-Thr27 bond in the B chain of oxidized insulin Endopeptidases from fungi Organic Nitrogen Peptidase 0 0 -I01 Inhibitors of serine endopeptidases Inhibitors of serine endopeptidases Organic Nitrogen Peptidase 0 0 -I03B Inhibit serine peptidases, particularly belonging to family S1; Members of family I3 inhibit serine peptidases by the Laskowski mechanism Inhibitors of serine and some other peptidases Organic Nitrogen Peptidase 0 0 -I03A Inhibit serine peptidases, particularly belonging to family S1; Members of family I3 inhibit serine peptidases by the Laskowski mechanism Inhibitors of serine and some other peptidases Organic Nitrogen Peptidase 0 0 -I05 A single inhibitor of serine peptidases A single inhibitor of serine peptidases Organic Nitrogen Peptidase 0 0 -I06 Serine peptidase inhibitors Serine peptidase inhibitors Organic Nitrogen Peptidase 0 0 -I07 Serine endopeptidase inhibitors Serine endopeptidase inhibitors Organic Nitrogen Peptidase 0 0 -I09 Inhibitors of serine peptidases of the subtilisin family (S8) Inhibitors of serine peptidases of the subtilisin family (S8) Organic Nitrogen Peptidase 0 0 -I10 Serine endopeptidase inhibitors Serine endopeptidase inhibitors Organic Nitrogen Peptidase 0 0 -I100 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I101 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I102 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I11 A single serine endopeptidase inhibitor, ecotin A single serine endopeptidase inhibitor, ecotin Organic Nitrogen Peptidase 0 0 -I12 Inhibitors of serine endopeptidases in clan PA Inhibitors of serine endopeptidases in clan PA Organic Nitrogen Peptidase 0 0 -I13 Inhibitors of serine peptidases Inhibitors of serine peptidases Organic Nitrogen Peptidase 0 0 -I14 Inhibitors of the serine endopeptidase thrombin Inhibitors of the serine endopeptidase thrombin Organic Nitrogen Peptidase 0 0 -I15 Inhibitors of serine endopeptidases in family S1 Inhibitors of serine endopeptidases in family S1 Organic Nitrogen Peptidase 0 0 -I16 Inhibitors of serine endopeptidases and at least one metallopeptidase Inhibitors of serine endopeptidases and at least one metallopeptidase Organic Nitrogen Peptidase 0 0 -I17 Serine endopeptidase inhibitors Serine endopeptidase inhibitors Organic Nitrogen Peptidase 0 0 -I18 Inhibitors of trypsin and other endopeptidases in family S1 Inhibitors of trypsin and other endopeptidases in family S1 Organic Nitrogen Peptidase 0 0 -I19 Inhibitors of serine endopeptidases Inhibitors of serine endopeptidases Organic Nitrogen Peptidase 0 0 -I20 Serine endopeptidase inhibitors Serine endopeptidase inhibitors Organic Nitrogen Peptidase 0 0 -I21 Inhibitor of a serine endopeptidase from family S8 Inhibitor of a serine endopeptidase from family S8 Organic Nitrogen Peptidase 0 0 -I22 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I23 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I26 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I27 Inhibitors of calpains (in peptidase family C2); roles in nerve growth, muscle homeostasis, signal transduction and apoptosis Inhibitors of calpains (in peptidase family C2) Organic Nitrogen Peptidase 0 0 -I28 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I30 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I31 Inhibitors primarily of the papain-like cysteine peptidases in family C1 known as the thyropins Inhibitors primarily of the papain-like cysteine peptidases Organic Nitrogen Peptidase 0 0 -I33 Inhibitors of aspartic peptidases (all of which are endopeptidases) from family A1 Inhibitors of aspartic peptidases (all of which are endopeptidases) Organic Nitrogen Peptidase 0 0 -I34 Inhibitor of saccharopepsin from Saccharomyces cerevisiae Inhibitor of saccharopepsin from Saccharomyces cerevisiae Organic Nitrogen Peptidase 0 0 -I35 Inhibitors of metalloendopeptidases (matrixins) in family M10A and M12B Inhibitors of metalloendopeptidases (matrixins) Organic Nitrogen Peptidase 0 0 -I37 a metallocarboxypeptidase inhibitor of family M14 metallocarboxypeptidase inhibitor Organic Nitrogen Peptidase 0 0 -I38 Inhibitors of metalloendopeptidases in subfamily M10 Inhibitors of metalloendopeptidases in subfamily M10 Organic Nitrogen Peptidase 0 0 -I39 interact with endopeptidases regardless of catalytic type Mammalian alpha-macroglobulin and other large homologous proteins that interact with endopeptidases regardless of catalytic type Organic Nitrogen Peptidase 0 0 -I40 Bombyx subtilisin inhibitor, an inhibitor of serine peptidases from family S8 Bombyx subtilisin inhibitor, an inhibitor of serine peptidases from family S8 Organic Nitrogen Peptidase 0 0 -I41 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I42 Inhibitors of cysteine endopeptidases from family C1 Inhibitors of cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -I44 inhibited is carboxypeptidase A, but does not affect other members of M14 Inhibitors of metallocarboxypeptidases in family M14 Organic Nitrogen Peptidase 0 0 -I45 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I46 Inhibitors of peptidases in family M14 Leech carboxypeptidase inhibitor (LCI) Organic Nitrogen Peptidase 0 0 -I47 Inhibitors of metallocarboxypeptidases in family M14 Inhibitors of metallocarboxypeptidases in family M14 Organic Nitrogen Peptidase 0 0 -I48 Inhibitors of cysteine endopeptidases Inhibitors of cysteine endopeptidases from family C1 including papain, cathepsin L, cathepsin B, stem bromelain, but not cathepsin H, trypsin, and pepsin Organic Nitrogen Peptidase 0 0 -I49 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I52 strong inhibition of coagulation factor Xa and weak inhibition of other peptidases in family S1 such as trypsin Inhibitors of coagulation factor Xa Organic Nitrogen Peptidase 0 0 -I53 Inhibitors of the serine-type endopeptidase thrombin; prevent conversion of fibrinogen to fibrin Inhibitors of the serine-type endopeptidase thrombin Organic Nitrogen Peptidase 0 0 -I54 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I55 aspartic peptidase inhibitor aspartic peptidase inhibitor Organic Nitrogen Peptidase 0 0 -I56 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I57 Inhibitors of cysteine endopeptidases in family C47, the staphopains Inhibitors of cysteine endopeptidases in family C47, the staphopains Organic Nitrogen Peptidase 0 0 -I58 Inhibitor of the cysteine endopeptidase, specifically staphopain A Inhibitor of the cysteine endopeptidase, specifically staphopain A Organic Nitrogen Peptidase 0 0 -I59 shown to inhibit thrombin; facilitates the feeding of the organism by delaying the clotting of the blood of the host Anticoagulant proteins from blood-feeding hemiptera Organic Nitrogen Peptidase 0 0 -I60 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I61 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I62 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I64 Proteins that inhibit coagulation Proteins that inhibit coagulation Organic Nitrogen Peptidase 0 0 -I65 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I66 Inhibitors, specificity unknown; Members include Lentinus peptidase inhibitor Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I67 Inhibitors of cysteine endopeptidases, specifically stem bromelain as well as weak inhibition of trypsin Inhibitors of cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -I68 Carboxypeptidase inhibitor, specifically those from subfamily M14A; suggested to enhance endogenous fibrinolysis Carboxypeptidase inhibitor Organic Nitrogen Peptidase 0 0 -I69 Inhibitors, specificity unknown; has been shown prevoiouslt to inhibit streptopain Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I70 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I71 Cysteine peptidase inhibitors from family C1 and calpain from family C2 Cysteine peptidase inhibitors Organic Nitrogen Peptidase 0 0 -I72 Inhibitors of the serine peptidase thrombin Inhibitors of the serine peptidase thrombin Organic Nitrogen Peptidase 0 0 -I73 Inhibitors of serine-type endopeptidases Inhibitors of serine-type endopeptidases, specifically trypsin Organic Nitrogen Peptidase 0 0 -I74 Inhibitors of the serine-type endopeptidase thrombin; Thrombin is the final peptidase in the blood coagulation cascade in mammals Inhibitors of the serine-type endopeptidase thrombin Organic Nitrogen Peptidase 0 0 -I76 Inhibitors of the serine-type endopeptidase thrombin; Thrombin is the final peptidase in the blood coagulation cascade in mammals Inhibitors of the serine-type endopeptidase thrombin Organic Nitrogen Peptidase 0 0 -I77 Inhibitors of the serine-type endopeptidase thrombin; Thrombin is the final peptidase in the blood coagulation cascade in mammals Inhibitors of the serine-type endopeptidase thrombin Organic Nitrogen Peptidase 0 0 -I78 Inhibitors of serine-type endopeptidases Inhibitors of serine-type endopeptidases Organic Nitrogen Peptidase 0 0 -I79 Inhibitors of cysteine peptidases from family C1 (especially PIP1 and RCR3); host defensive protein that is secreted to the apoplast and initiates a hypersensitive response in the presence of the Avr2 inhibitor and the RCR3 peptidase Inhibitors of cysteine peptidases Organic Nitrogen Peptidase 0 0 -I80 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I81 Inhibitors of cysteine endopeptidases from family C1 (especially TgCPL peptidase) Inhibitors of cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -I82 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I83 Inhibitors of serine endopeptidases; Inlcude peptidases involved in Insect defence mechanisms against pathogenic attack Inhibitors of serine endopeptidases Organic Nitrogen Peptidase 0 0 -I84 serine peptidases from family S8 (especially perkisin) and trypsin from S1 Serine peptidase inhibitors Organic Nitrogen Peptidase 0 0 -I85 inhibit cysteine peptidases from family C1 and trypsins; generally called macrocypins Cysteine and serine peptidase inhibitors Organic Nitrogen Peptidase 0 0 -I86 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I88 Serine endopeptidase inhibitors Serine endopeptidase inhibitors Organic Nitrogen Peptidase 0 0 -I89 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I90 Inhibitors of trypsin Inhibitors of trypsin Organic Nitrogen Peptidase 0 0 -I92 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I93 Inhibitors of metallopeptidases Inhibitors of metallopeptidases Organic Nitrogen Peptidase 0 0 -I94 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I95 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I96 Inhibitors, specificity unknown; extracellular adherence protein Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I98 Inhibitors, specificity unknown; extracellular adherence protein Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I99 Inhibitors, specificity unknown Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -M01 Catlytic type: Metallo; each is capable of releasing a variety of residues; none have been shown to hydrolyse Xaa-Pro-bonds Aminopeptidases Organic Nitrogen Peptidase 0 0 -M02 Catlytic type: Metallo; exopeptidases acting near the C-terminus of oligopeptides Metallo-exopeptidases Organic Nitrogen Peptidase 0 0 -M04 Catlytic type: Metallo; cleave of Xaa+Yaa, in which Xaa is a hydrophobic residue and Yaa is Leu, Phe, Ile, or Val; secreted enzymes that degrade extracellular proteins and peptides for bacterial nutrition; member is thermolysin Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M05 Catlytic type: Metallo; a member is mycolysin Metalloendopeptidase Organic Nitrogen Peptidase 0 0 -M06 Catlytic type: Metallo; digesting two classes of antibacterial humoral factors: cecropins and attacins, with no specific cleaving pattern; may contribute to the virulence of Bacillus thuringiensis Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M07 Catlytic type: Metallo; a member is snapalysin; only known activity is cleavage of proteins of skimmed milk Metalloendopeptidase, snapalysin Organic Nitrogen Peptidase 0 0 -M08 Catlytic type: Metallo; P1 residue at a site of cleavage is often Leu, Ile or Val, and Lys in P3 or P4 may be favourable; most abundant surface protein of leishmania promastigotes and contributes to its virulence Metallo-endopeptidase leishmanolysin and its homologues Organic Nitrogen Peptidase 0 0 -M09B Catlytic type: Metallo; Vibrio collegenases cleave at XaaGly bond in the alpha-1 chain type of collagen; Clostridium collegenases cleave all three collagens at Yaa-Gly bonds in the repeating Gly-Xaa-Yaa collagen sequence Bacterial collagenases from Vibrio and Clostridium Organic Nitrogen Peptidase 0 0 -M09A Catlytic type: Metallo; Vibrio collegenases cleave at XaaGly bond in the alpha-1 chain type of collagen; Clostridium collegenases cleave all three collagens at Yaa-Gly bonds in the repeating Gly-Xaa-Yaa collagen sequence Bacterial collagenases from Vibrio and Clostridium Organic Nitrogen Peptidase 0 0 -M100 Catlytic type: Metallo; a member is spartan peptidase (Homo sapiens) spartan peptidase Organic Nitrogen Peptidase 0 0 -M101 Catlytic type: Metallo; a member is flagellinolysin (Clostridium haemolyticum) flagellinolysin Organic Nitrogen Peptidase 0 0 -M102 Catlytic type: Metallo; a member is DA1 peptidase (Arabidopsis thaliana) DA1 peptidase Organic Nitrogen Peptidase 0 0 -M11 Catlytic type: Metallo; degrades the proline- and hydroxyproline-rich proteins of the algal cell wall; a member is Gametolysin; degradation of the cell wall allows the release of gametes A metallo-endopeptidase, gametolysin Organic Nitrogen Peptidase 0 0 -M17 Catlytic type: Metallo; any N-terminal amino acid can be released from dipeptides and polypeptides, although there is a preference for leucine; bonds with proline in P1 are not cleaved; maximally active between pH 9 and 9.5 Aminopeptidases Organic Nitrogen Peptidase 0 0 -M18 Catlytic type: Metallo; acting on N-terminal leucine and most other amino acids Metalloaminopeptidases Organic Nitrogen Peptidase 0 0 -M19 Catlytic type: Metallo; cleaves dipeptides and beta-lactams; cleaves dipeptides with D-amino acids in the P1 position; often membrane localized Dipeptidases Organic Nitrogen Peptidase 0 0 -M22 Catlytic type: Metallo; cleaves only proteins that are {O}-sialoglycosylated; shown to cleave glycophorin A and the leukocyte surface antigens CD34, CD43, CD44 and CD45 Endopeptidases Organic Nitrogen Peptidase 0 0 -M24C Catlytic type: Metallo Exopeptidases that require co-catalytic ions of cobalt or manganese Organic Nitrogen Peptidase 0 0 -M24B Catlytic type: Metallo; cleave the bond XaaPro; found in eukaryotes associated with collagen recycling Exopeptidases that require co-catalytic ions of cobalt or manganese Organic Nitrogen Peptidase 0 0 -M24A Catlytic type: Metallo; cleave the Met-Xaa (where Xaa is any amino acid) bond in the removal of the initiating N-terminal methionine from newly synthesized proteins; essential for the removal of the initiating methionine of many proteins, acting co-translationally in association with the ribosomes Exopeptidases that require co-catalytic ions of cobalt or manganese Organic Nitrogen Peptidase 0 0 -M26 Catlytic type: Metallo; cleaves the heavy chain of human IgA1 at the Pro227-Thr228 bond; tightly associated with the bacterial cell surface Endopeptidases Organic Nitrogen Peptidase 0 0 -M28F Catlytic type: Metallo; able to release a variety of N-terminal amino acids Aminopeptidases and carboxypeptidases Organic Nitrogen Peptidase 0 0 -M28E Catlytic type: Metallo; able to release a variety of N-terminal amino acids Aminopeptidases and carboxypeptidases Organic Nitrogen Peptidase 0 0 -M28D Catlytic type: Metallo; able to release a variety of N-terminal amino acids Aminopeptidases and carboxypeptidases Organic Nitrogen Peptidase 0 0 -M28C Catlytic type: Metallo; able to release a variety of N-terminal amino acids, with preference for basic amino acids Aminopeptidases and carboxypeptidases Organic Nitrogen Peptidase 0 0 -M28B Catlytic type: Metallo; able to release a variety of N-terminal amino acids, with preference for C-terminal glutamates Aminopeptidases and carboxypeptidases Organic Nitrogen Peptidase 0 0 -M28A Catlytic type: Metallo; able to release a variety of N-terminal amino acids Aminopeptidases and carboxypeptidases Organic Nitrogen Peptidase 0 0 -M29 Catlytic type: Metallo; broad specificity, but preferentially releases Leu, Val, Phe or Tyr; can release Pro but is unable to cleave peptides with Pro in P1. Leu-NHPhNO2 is the usual synthetic substrate Aminopeptidases Organic Nitrogen Peptidase 0 0 -M30 Catlytic type: Metallo; cleaves azocasein and gelatin Endopeptidases Organic Nitrogen Peptidase 0 0 -M32 Catlytic type: Metallo; hydrolyses amino acids with long side chains most readily Metallocarboxypeptidases Organic Nitrogen Peptidase 0 0 -M34 Catlytic type: Metallo; cleaves at the Xbb-Xbb-Xbb-Xbb-Xaa-Xcc-Xaa+Xcc bond, in which Xaa is any amino acid, Xbb is Lys or Arg, and Xcc is a hydrophobic amino acid Highly-selective bacterial endopeptidase Organic Nitrogen Peptidase 0 0 -M35 Catlytic type: Metallo; cleaves Xaa-Lys bonds, in which Xaa can even be Pro Fungal metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M36 Catlytic type: Metallo; hydrolyses laminins, elastin and collagen, with a preference for cleavage on the amino side of hydrophobic residues with bulky side-chains; a member is funalysin Endopeptidases Organic Nitrogen Peptidase 0 0 -M49 Catlytic type: Metallo; DPPIII releases N-terminal dipeptides sequentially from a peptide. Angiotensins II and III, Leu-enkephalin, prolactin and alpha-melanocyte-stimulating hormone are readily cleaved, whereas tripeptides are poor substrates and angiotensin I and polypeptides of more than ten residues are not cleaved. In addition, proline is not accepted in P1 or P1’ . The recommended synthetic substrate is Arg-Arg|+|NHMec (<%Chen & Barrett, 2004[20040525A373]%>).; polypeptides of more than ten residues are not cleaved and proline in the P1 or P1 position will not cleave Dipeptidylpeptidase Organic Nitrogen Peptidase 0 0 -M50B Catlytic type: Metallo; activates the factor sigmaK precursor by cleaving off a 20-residue propeptide; cleavage occurs within, or very close to, membranes Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M50A Catlytic type: Metallo; cleaves a Leu-Cys bond in the first transmembrane helix of the substrate; cleavage occurs within, or very close to, membranes Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M54 Catlytic type: Metallo; eukaryote archelysin has a preference for arginine in P1; the AMZ1 protein cleaves alanyl bonds Aminopeptidases, sometimes termed archaelysins or archaemetzincins Organic Nitrogen Peptidase 0 0 -M55 Catlytic type: Metallo; cleaves D-Ala-D-Ala and D-Ala-Gly-Gly Aminopeptidase and a number of uncharacterised putative peptidases Organic Nitrogen Peptidase 0 0 -M57 Catlytic type: Metallo Endopeptidase Organic Nitrogen Peptidase 0 0 -M61 Catlytic type: Metallo; hydrolyses a broad range of N-terminal amino acids, but shows a preference for glycine or alanine; degradation of extracellular proteins for uptake of amino acids Aminopeptidase Organic Nitrogen Peptidase 0 0 -M64 Catlytic type: Metallo; cleaves both the alpha1 and alpha2 A2m(1) heavy chains at the Val-Pro-Cys-Pro221Val222 peptide bond located just before the hinge region; may help the organisms to exist as a commensal organism in the human intestine Highly selective metalloendopeptidase Organic Nitrogen Peptidase 0 0 -M66 Catlytic type: Metallo; cleavse C1 esterase inhibitor A single metallopeptidase Organic Nitrogen Peptidase 0 0 -M72 Catlytic type: Metallo; cleaves peptide bonds at the amino side of aspartate or cysteic acid Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M73 Catlytic type: Metallo; cleaves proteins such as caseins, actin and collagen type I, with preference for bonds with an aliphatic or hydrophilic residue in P1 Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M74 Catlytic type: Metallo; hydrolyses the Ala-D-Glu-meso-diaminopimelateD-Ala bond in the crosslinking peptide and the Ala-D-Glu-meso-diaminopimelatemeso-diaminopimelate-D-Glu-Ala bond between crosslinking peptides Murein endopeptidase MepA Organic Nitrogen Peptidase 0 0 -M75 Catlytic type: Metallo; cleaves the oxidized insulin B chain with a preference for aromatic hydrophobic amino acids at P1 Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M76 Catlytic type: Metallo; processes the mitochondrially-encoded, subunit Atp6 of the F1FO-ATP synthase Endopeptidases Organic Nitrogen Peptidase 0 0 -M77 Catlytic type: Metallo Aminopeptidases Organic Nitrogen Peptidase 0 0 -M80 Catlytic type: Metallo Isopeptidases Organic Nitrogen Peptidase 0 0 -M81 Catlytic type: Metallo; degrades both microcystins LR and LA Metallopeptidases Organic Nitrogen Peptidase 0 0 -M82 Catlytic type: Metallo; inactivates the anti-sigma factor RsiW by performing the first of several cleavages Endopeptidases Organic Nitrogen Peptidase 0 0 -M84 Catlytic type: Metallo; The only proteolytic activity reported is against azocasein Endopeptidases Organic Nitrogen Peptidase 0 0 -M85 Catlytic type: Metallo; cleaves the p65 subunit of NF-kappaB, but cleavage positions have not been identified Endopeptidases Organic Nitrogen Peptidase 0 0 -M87 Catlytic type: Metallo; Self-cleavage occurs at a well-conserved site, in which P1 is basic or Gly, P1 is small (predominantly Gly or Ala), P2 is hydrophobic, P3 is Tyr and P6 is Gl Self-cleaving proteins Organic Nitrogen Peptidase 0 0 -M88 Catlytic type: Metallo; protects the bacterium from immunological attack by impairing the extravasation of neutrophils Endopeptidases Organic Nitrogen Peptidase 0 0 -M90 Catlytic type: Metallo; member is MtfA peptidase, involved in control of the glucose-phosphotransferase system Aminopeptidases Organic Nitrogen Peptidase 0 0 -M91 Catlytic type: Metallo; secreted by type III secretion systems in E. coli Endopeptidases Organic Nitrogen Peptidase 0 0 -M93 Catlytic type: Metallo Organic Nitrogen Peptidase 0 0 -M95 Catlytic type: Metallo; member is abylysin (Pyrococcus abyssi) Organic Nitrogen Peptidase 0 0 -M96 Catlytic type: Metallo; N-terminal octapeptide is removed from the Wnt-3a protein, with cleavage occurring at at Leu+Ala bond signaling peptidase Organic Nitrogen Peptidase 0 0 -M97 Catlytic type: Metallo; a member is EcxAB peptidase (Escherichia coli) Organic Nitrogen Peptidase 0 0 -M98 Catlytic type: Metallo; a member is YghJ g.p. (Escherichia coli) Organic Nitrogen Peptidase 0 0 -M99 Catlytic type: Metallo; a member is Csd4 peptidase (Helicobacter pylori) Organic Nitrogen Peptidase 0 0 -N06 Catlytic type: Asparagine; cleaves at the tetrapeptide Asn+Pro-Thr-His; essential for mediating the switch in the secretion of proteins in the type III secretion system Autoprocessing endopeptidases Organic Nitrogen Peptidase 0 0 -P01 Catlytic type: Mixed (C, S, T) catalytic type; releases amino acid residues in the L-configuration in its action on peptides; part of the general peptidase pool Aminopeptidases and self-processing proteins Organic Nitrogen Peptidase 0 0 -P02B Catlytic type: Mixed (C, S, T) catalytic type; polycystin-1 mucin-like hormone receptor Organic Nitrogen Peptidase 0 0 -P02A Catlytic type: Mixed (C, S, T) catalytic type; EGF-like module containing mucin-like hormone receptor-like 2 mucin-like hormone receptor Organic Nitrogen Peptidase 0 0 -S10 Catlytic type: Serine; preference for hydrophobic residues in positions P1 and P1 OR preference for the basic amino acids either side of the scissile bond Carboxypeptidases Organic Nitrogen Peptidase 0 0 -S13 Catlytic type: Serine; hydrolyses the D-Ala-D-Ala bond in the cross-linking peptide precursor OR degrades this D-Ala-meso-2,6-diaminopimelate bond Peptidases that cleave D-Ala bonds, acting either as carboxypeptidases or as atypical 'endopeptidases' Organic Nitrogen Peptidase 0 0 -S15 Catlytic type: Serine; cleaves Xaa-Pro from the N-terminus of peptides provided that there is not a Pro in the P2 or P1 positions; plays important role in degradation of casein Xaa-Pro dipeptidyl peptidase and its homologues Organic Nitrogen Peptidase 0 0 -S37 Catlytic type: Serine; activate the transglutaminase precursor by removal of a leading tri- or tetrapeptide Tripeptidyl-peptidase from {Streptomyces} Organic Nitrogen Peptidase 0 0 -S41B Catlytic type: Serine; recognizes a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr and Zaa is preferably Ala and cleaves at a variable distance from the C-terminus; important for the degradation of incorrectly synthesized proteins Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S41A Catlytic type: Serine; recognizes a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr and Zaa is preferably Ala and cleaves at a variable distance from the C-terminus; important for the degradation of incorrectly synthesized proteins Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S45 Catlytic type: Serine; amino side of the catalytic serine is cleaved in an intramolecular reaction, and then there is an intermolecular cleavage of a bond further toward the N-terminus; a member is penicillin G acylase precursor (Escherichia coli) Self-cleaving precursor proteins of N-terminal nucleophile acylases Organic Nitrogen Peptidase 0 0 -S46 Catlytic type: Serine; long peptides and N-terminally blocked peptides are not cleaved Dipeptidyl-peptidases from bacteria Organic Nitrogen Peptidase 0 0 -S48 Catlytic type: Serine the protein HetR that is reported to be an autolytic serine endopeptidase Organic Nitrogen Peptidase 0 0 -S51 Catlytic type: Serine; hydrolyses Asp-Xaa dipeptides in which Xaa is not Glu, Asn or Gln; nutritional function in bacteria Exopeptidases that hydrolyse alpha-aspartyl bonds Organic Nitrogen Peptidase 0 0 -S55 Catlytic type: Serine Endopeptidases Organic Nitrogen Peptidase 0 0 -S59 Catlytic type: Serine; cleaves at the Phe-Ser bond within the active site motif Autolytic endopeptidase Organic Nitrogen Peptidase 0 0 -S60 Catlytic type: Serine; cleaves at arginyl and lysyl bonds Endopeptidase Organic Nitrogen Peptidase 0 0 -S63 Catlytic type: Serine Autolytic endopeptidases Organic Nitrogen Peptidase 0 0 -S64 Catlytic type: Serine; Ssy5 peptidase is believed to cleave both itself and the Stp1 protein within a motif that is conserved between the two proteins; this contains the sequence PISMS that is required for cleavage to take place; plays a key role in the adaptive response of Saccharomyces cerevisiae and likely other fungi Endopeptidases Organic Nitrogen Peptidase 0 0 -S66 Catlytic type: Serine; hydrolyses the bond to the C-terminal D-Ala in tetrapeptide peptidoglycan fragments that contain an L-configured residue (lysine or meso-diaminopimelic acid) that is attached a C-terminal D-alanine residue; produced when bacterial cell walls are degraded Bacterial LD-carboxypeptidases Organic Nitrogen Peptidase 0 0 -S68 Catlytic type: Serine; autolyses at two Ser-Trp bonds; proteolysis leads to activation of cell survival or apoptotic pathways Autolytic endopeptidases Organic Nitrogen Peptidase 0 0 -S70 Catlytic type: Serine; a member is LepA Serine-type endopeptidases Organic Nitrogen Peptidase 0 0 -S71 Catlytic type: Serine; autolytic cleavage at Gly-Ser bond; involved in the synthesis of Mucin 1 Self-cleaving precursor proteins Organic Nitrogen Peptidase 0 0 -S72 Catlytic type: Serine; cleaves at arginyl and lysyl bonds Autolytic serine-type endopeptidases Organic Nitrogen Peptidase 0 0 -S79 Catlytic type: Serine; autoactivation Self-processing proteins Organic Nitrogen Peptidase 0 0 -S82 Catlytic type: Serine autocrine proliferation repressor protein A Organic Nitrogen Peptidase 0 0 -T02 Catlytic type: Threonine; hydrolyses the GlcNAc+Asn (the natural linkage structure between protein and carbohydrate in Asn-linked glycoproteins) and taspase-1 which cleaves aspartyl bonds D+GADD and D+GVDD N-terminal nucleophile hydrolases Organic Nitrogen Peptidase 0 0 -T05 Catlytic type: Threonine Self-processing ornithine acetyltransferase precursor Organic Nitrogen Peptidase 0 0 -T06 Catlytic type: Threonine; cleaves itself at the Leu3048|+|Thr bond; cleavage occurs in the endoplasmic reticulum or the Golgi Threonine-type autoprocessing endopeptidases Organic Nitrogen Peptidase 0 0 -T07 Catlytic type: Threonine CwpV (Clostridium difficile) self-cleaving threonine peptidase Organic Nitrogen Peptidase 0 0 -T08 Catlytic type: Threonine; member is HopB1 g.p. (Pseudomonas syringae) Organic Nitrogen Peptidase 0 0 -U49 cleaves domain I of elongation factor Tu; important role in bacterial cell death Lit peptidase from Escherischia coli Organic Nitrogen Peptidase 0 0 -U56 hydrolyses substrates of chymotrypsin, trypsin, and casein Endopeptidases Organic Nitrogen Peptidase 0 0 -U57 SpoIVA and YrbA are degraded during stage IV of the sporulation process Endopeptidases involved in bacterial sporulation Organic Nitrogen Peptidase 0 0 -U62 Catlytic type: Metallo; cleaves the bacteriocin microcin B17 precursor at Gly26|+|Val27 Microcin-processing peptidases Organic Nitrogen Peptidase 0 0 -U69 Self-processing occurs at the Ser846|+|Ala bond. Self-processing peptidases Organic Nitrogen Peptidase 0 0 -U72 Pup (prokaryotic ubiquitin-like protein) tags bacterial protiens for degradation. ; In releasing Pup from conjugates, Dop acts as an isopeptidase. In degradation of Pup, Dop acts as an endopeptidase. Isopeptidase and endopeptidases Organic Nitrogen Peptidase 0 0 -U74 Catlytic type: Peptidase of unknown catalytic type neprosin Organic Nitrogen Peptidase 0 0 -U75 Catlytic type: Peptidase of unknown catalytic type Ras/Rap1-specific peptidase Organic Nitrogen Peptidase 0 0 -K01697 cystathionine beta-synthase [EC:4.2.1.22] [RN:R01290] Cysteine biosynthesis, homocysteine + serine => cysteine Organic Nitrogen Amino Acid 0 0 -K10150 cystathionine beta-synthase [EC:4.2.1.22] [RN:R01290] Cysteine biosynthesis, homocysteine + serine => cysteine Organic Nitrogen Amino Acid 0 0 -K01758 cystathionine gamma-lyase [EC:4.4.1.1] [RN:R01001] Cysteine biosynthesis, homocysteine + serine => cysteine Organic Nitrogen Amino Acid 0 0 -K00789 S-adenosylmethionine synthetase [EC:2.5.1.6] [RN:R00177] Cysteine biosynthesis, methionine => cysteine Organic Nitrogen Amino Acid 0 0 -K17462 putative AdoMet-dependent methyltransferase [EC:2.1.1.-] [RN:R10404] Cysteine biosynthesis, methionine => cysteine Organic Nitrogen Amino Acid 0 0 -K01243 S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase [EC:3.2.2.9] [RN:R00194] Cysteine biosynthesis, methionine => cysteine Organic Nitrogen Amino Acid 0 0 -K18284 S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase [EC:3.2.2.9] [RN:R00194] Cysteine biosynthesis, methionine => cysteine Organic Nitrogen Amino Acid 0 0 -K07173 S-ribosylhomocysteine lyase [EC:4.4.1.21] [RN:R01291] Cysteine biosynthesis, methionine => cysteine Organic Nitrogen Amino Acid 0 0 -K17216 cystathionine beta-synthase (O-acetyl-L-serine) [EC:2.5.1.134] [RN:R10305] Cysteine biosynthesis, methionine => cysteine Organic Nitrogen Amino Acid 0 0 -K17217 cystathionine gamma-lyase [EC:4.4.1.1] [RN:R01001] Cysteine biosynthesis, methionine => cysteine Organic Nitrogen Amino Acid 0 0 -K00931 glutamate 5-kinase [EC:2.7.2.11] [RN:R00239] Proline biosynthesis, glutamate => proline Organic Nitrogen Amino Acid 0 0 -K00147 glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] [RN:R03313] Proline biosynthesis, glutamate => proline Organic Nitrogen Amino Acid 0 0 -K12657 delta-1-pyrroline-5-carboxylate synthetase [EC:2.7.2.11 1.2.1.41] [RN:R00239 R03313] Proline biosynthesis, glutamate => proline Organic Nitrogen Amino Acid 0 0 -K00286 pyrroline-5-carboxylate reductase [EC:1.5.1.2] [RN:R01251] Proline biosynthesis, glutamate => proline Organic Nitrogen Amino Acid 0 0 -K00928 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K12524 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K12525 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K12526 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [RN:R02291] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01714 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] [RN:R10147] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00215 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] [RN:R04198 R04199] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00674 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase [EC:2.3.1.117] [RN:R04365] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00821 N-succinyldiaminopimelate aminotransferase [EC:2.6.1.17] [RN:R04475] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K14267 N-succinyldiaminopimelate aminotransferase [EC:2.6.1.17] [RN:R04475] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01439 succinyl-diaminopimelate desuccinylase [EC:3.5.1.18] [RN:R02734] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01778 diaminopimelate epimerase [EC:5.1.1.7] [RN:R02735] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01586 diaminopimelate decarboxylase [EC:4.1.1.20] [RN:R00451] Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00928 aspartate kinase [EC:2.7.2.4] [RN:R00480] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K12524 aspartate kinase [EC:2.7.2.4] [RN:R00480] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K12525 aspartate kinase [EC:2.7.2.4] [RN:R00480] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K12526 aspartate kinase [EC:2.7.2.4] [RN:R00480] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [RN:R02291] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K00003 homoserine dehydrogenase [EC:1.1.1.3] [RN:R01773 R01775] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K00651 homoserine O-succinyltransferase [EC:2.3.1.46] [RN:R01777] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K01739 cystathionine gamma-synthase [EC:2.5.1.48] [RN:R03260] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K01760 cystathionine beta-lyase [EC:4.4.1.8] [RN:R01286] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K00548 methionine synthase [EC:2.1.1.13 2.1.1.14] [RN:R00946 R04405] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K00549 methionine synthase [EC:2.1.1.13 2.1.1.14] [RN:R00946 R04405] Methionine biosynthesis, apartate => homoserine => methionine Organic Nitrogen Amino Acid 0 0 -K00928 aspartate kinase [EC:2.7.2.4] [RN:R00480] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K12524 aspartate kinase [EC:2.7.2.4] [RN:R00480] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K12525 aspartate kinase [EC:2.7.2.4] [RN:R00480] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K12526 aspartate kinase [EC:2.7.2.4] [RN:R00480] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [RN:R02291] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K00003 homoserine dehydrogenase [EC:1.1.1.3] [RN:R01773 R01775] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K00872 homoserine kinase [EC:2.7.1.39] [RN:R01771] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K02204 homoserine kinase [EC:2.7.1.39] [RN:R01771] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K02203 homoserine kinase [EC:2.7.1.39] [RN:R01771] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K01733 threonine synthase [EC:4.2.3.1] [RN:R01466] Threonine biosynthesis, aspartate => homoserine => threonine Organic Nitrogen Amino Acid 0 0 -K01652 acetolactate synthase [EC:2.2.1.6] [RN:R00226 R08648] Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K01653 acetolactate synthase [EC:2.2.1.6] [RN:R00226 R08648] Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K11258 acetolactate synthase [EC:2.2.1.6] [RN:R00226 R08648] Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K00053 ketol-acid reductoisomerase [EC:1.1.1.86] [RN:R05071 R04440 R04439 R05069 R05068] Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K01687 dihydroxy-acid dehydratase [EC:4.2.1.9] [RN:R04441 R05070] Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] [RN:R01214 R02199] Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K00058 D-3-phosphoglycerate dehydrogenase [EC:1.1.1.95] [RN:R01513] Serine biosynthesis, glycerate-3P => serine Organic Nitrogen Amino Acid 0 0 -K00831 phosphoserine aminotransferase [EC:2.6.1.52] [RN:R04173] Serine biosynthesis, glycerate-3P => serine Organic Nitrogen Amino Acid 0 0 -K01079 phosphoserine phosphatase [EC:3.1.3.3] [RN:R00582] Serine biosynthesis, glycerate-3P => serine Organic Nitrogen Amino Acid 0 0 -K00640 serine O-acetyltransferase [EC:2.3.1.30] [RN:R00586] Cysteine biosynthesis, serine => cysteine Organic Nitrogen Amino Acid 0 0 -K01738 cysteine synthase [EC:2.5.1.47] [RN:R00897] Cysteine biosynthesis, serine => cysteine Organic Nitrogen Amino Acid 0 0 -K13034 cysteine synthase [EC:2.5.1.47] [RN:R00897] Cysteine biosynthesis, serine => cysteine Organic Nitrogen Amino Acid 0 0 -K17069 cysteine synthase [EC:2.5.1.47] [RN:R00897] Cysteine biosynthesis, serine => cysteine Organic Nitrogen Amino Acid 0 0 -K01626 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54] [RN:R01826] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K03856 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54] [RN:R01826] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K13853 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54] [RN:R01826] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K01735 3-dehydroquinate synthase [EC:4.2.3.4] [RN:R03083] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K13829 3-dehydroquinate synthase [EC:4.2.3.4] [RN:R03083] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K03785 3-dehydroquinate dehydratase [EC:4.2.1.10] [RN:R03084] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K03786 3-dehydroquinate dehydratase [EC:4.2.1.10] [RN:R03084] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K00014 shikimate 5-dehydrogenase [EC:1.1.1.25] [RN:R02413] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K13832 3-dehydroquinate dehydratase [EC:4.2.1.10] [RN:R03084] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K13830 3-dehydroquinate synthase [EC:4.2.3.4] [RN:R03083] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K00891 shikimate kinase [EC:2.7.1.71] [RN:R02412] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K00800 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] [RN:R03460] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K01736 chorismate synthase [EC:4.2.3.5] [RN:R01714] Shikimate pathway, phosphoenolpyruvate + erythrose-4P => chorismate Organic Nitrogen Amino Acid 0 0 -K01657 anthranilate synthase [EC:4.1.3.27] [RN:R00985 R00986] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K01658 anthranilate synthase [EC:4.1.3.27] [RN:R00985 R00986] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K13503 anthranilate synthase [EC:4.1.3.27] [RN:R00985 R00986] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K13501 anthranilate synthase [EC:4.1.3.27] [RN:R00985 R00986] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K01656 anthranilate synthase [EC:4.1.3.27] [RN:R00985 R00986] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K00766 anthranilate phosphoribosyltransferase [EC:2.4.2.18] [RN:R01073] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K13497 anthranilate synthase [EC:4.1.3.27] [RN:R00985 R00986] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K01817 phosphoribosylanthranilate isomerase [EC:5.3.1.24] [RN:R03509] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K01609 indole-3-glycerol phosphate synthase [EC:4.1.1.48] [RN:R03508] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K13498 phosphoribosylanthranilate isomerase [EC:5.3.1.24] [RN:R03509] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K01695 tryptophan synthase [EC:4.2.1.20] [RN:R02722] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K01696 tryptophan synthase [EC:4.2.1.20] [RN:R02722] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K06001 tryptophan synthase [EC:4.2.1.20] [RN:R02722] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K01694 tryptophan synthase [EC:4.2.1.20] [RN:R02722] Tryptophan biosynthesis, chorismate => tryptophan Organic Nitrogen Amino Acid 0 0 -K01850 chorismate mutase [EC:5.4.99.5] [RN:R01715] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K04092 chorismate mutase [EC:5.4.99.5] [RN:R01715] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K14187 chorismate mutase [EC:5.4.99.5] [RN:R01715] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K04093 chorismate mutase [EC:5.4.99.5] [RN:R01715] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K04516 chorismate mutase [EC:5.4.99.5] [RN:R01715] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K06208 chorismate mutase [EC:5.4.99.5] [RN:R01715] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K06209 chorismate mutase [EC:5.4.99.5] [RN:R01715] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K13853 chorismate mutase [EC:5.4.99.5] [RN:R01715] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K01713 prephenate dehydratase [EC:4.2.1.51] [RN:R01373] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K04518 prephenate dehydratase [EC:4.2.1.51] [RN:R01373] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K05359 prephenate dehydratase [EC:4.2.1.51] [RN:R01373] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K14170 chorismate mutase [EC:5.4.99.5] [RN:R01715] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K00832 aromatic-amino-acid transaminase [EC:2.6.1.57] [RN:R00694] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K00838 aromatic-amino-acid transaminase [EC:2.6.1.57] [RN:R00694] Phenylalanine biosynthesis, chorismate => phenylalanine Organic Nitrogen Amino Acid 0 0 -K01850 chorismate mutase [EC:5.4.99.5] [RN:R01715] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K04092 chorismate mutase [EC:5.4.99.5] [RN:R01715] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K14170 chorismate mutase [EC:5.4.99.5] [RN:R01715] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K04093 chorismate mutase [EC:5.4.99.5] [RN:R01715] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K04516 chorismate mutase [EC:5.4.99.5] [RN:R01715] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K06208 chorismate mutase [EC:5.4.99.5] [RN:R01715] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K06209 chorismate mutase [EC:5.4.99.5] [RN:R01715] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K13853 chorismate mutase [EC:5.4.99.5] [RN:R01715] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K00210 prephenate dehydrogenase [EC:1.3.1.12] [RN:R01728] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K04517 prephenate dehydrogenase [EC:1.3.1.12] [RN:R01728] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K14187 chorismate mutase [EC:5.4.99.5] [RN:R01715] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K00815 tyrosine aminotransferase [EC:2.6.1.5] [RN:R00734] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K00832 aromatic-amino-acid transaminase [EC:2.6.1.57] [RN:R00734] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K00838 aromatic-amino-acid transaminase [EC:2.6.1.57] [RN:R00734] Tyrosine biosynthesis, chorismate => tyrosine Organic Nitrogen Amino Acid 0 0 -K00765 ATP phosphoribosyltransferase [EC:2.4.2.17] [RN:R01071] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K02502 ATP phosphoribosyltransferase [EC:2.4.2.17] [RN:R01071] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K01523 phosphoribosyl-ATP pyrophosphohydrolase [EC:3.6.1.31] [RN:R04035] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K01496 phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19] [RN:R04037] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K11755 phosphoribosyl-ATP pyrophosphohydrolase [EC:3.6.1.31] [RN:R04035] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K14152 phosphoribosyl-ATP pyrophosphohydrolase [EC:3.6.1.31] [RN:R04035] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K01814 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16] [RN:R04640] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K02501 imidazole glycerol-phosphate synthase [EC:4.3.2.10] [RN:R04558] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K02500 imidazole glycerol-phosphate synthase [EC:4.3.2.10] [RN:R04558] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K01663 imidazole glycerol-phosphate synthase [EC:4.3.2.10] [RN:R04558] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K01693 imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19] [RN:R03457] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K00817 histidinol-phosphate aminotransferase [EC:2.6.1.9] [RN:R03243] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K04486 histidinol-phosphatase [EC:3.1.3.15] [RN:R03013] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K05602 histidinol-phosphatase [EC:3.1.3.15] [RN:R03013] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K18649 histidinol-phosphatase [EC:3.1.3.15] [RN:R03013] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K01089 imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase [EC:4.2.1.19 3.1.3.15] [RN:R03457 R03013] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K00013 histidinol dehydrogenase [EC:1.1.1.23] [RN:R03012 R01163] Histidine biosynthesis, PRPP => histidine Organic Nitrogen Amino Acid 0 0 -K00618 amino-acid N-acetyltransferase [EC:2.3.1.1] [RN:R00259] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K00619 amino-acid N-acetyltransferase [EC:2.3.1.1] [RN:R00259] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K14681 amino-acid N-acetyltransferase [EC:2.3.1.1] [RN:R00259] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K14682 amino-acid N-acetyltransferase [EC:2.3.1.1] [RN:R00259] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K00620 glutamate N-acetyltransferase / amino-acid N-acetyltransferase [EC:2.3.1.35 2.3.1.1] [RN:R00259 R02282] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K22477 amino-acid N-acetyltransferase [EC:2.3.1.1] [RN:R00259] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K22478 bifunctional N-acetylglutamate synthase/kinase [EC:2.3.1.1 2.7.2.8] [RN:R00259 R02649] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K00930 acetylglutamate kinase [EC:2.7.2.8] [RN:R02649] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K00145 N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38] [RN:R03443] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K12659 N-acetyl-gamma-glutamyl-phosphate reductase / acetylglutamate kinase [EC:1.2.1.38 2.7.2.8] [RN:R02649 R03443] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K00818 acetylornithine aminotransferase [EC:2.6.1.11] [RN:R02283] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K00821 acetylornithine aminotransferase [EC:2.6.1.11] [RN:R02283] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K01438 acetylornithine deacetylase [EC:3.5.1.16] [RN:R00669] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K14677 aminoacylase [EC:3.5.1.14] [RN:R00669] Ornithine biosynthesis, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K01948 carbamoyl-phosphate synthase (ammonia) [EC:6.3.4.16] [RN:R00149] Urea cycle Organic Nitrogen Amino Acid 0 0 -K00611 ornithine carbamoyltransferase [EC:2.1.3.3] [RN:R01398] Urea cycle Organic Nitrogen Amino Acid 0 0 -K01940 argininosuccinate synthase [EC:6.3.4.5] [RN:R01954] Urea cycle Organic Nitrogen Amino Acid 0 0 -K01755 argininosuccinate lyase [EC:4.3.2.1] [RN:R01086] Urea cycle Organic Nitrogen Amino Acid 0 0 -K14681 argininosuccinate lyase [EC:4.3.2.1] [RN:R01086] Urea cycle Organic Nitrogen Amino Acid 0 0 -K01476 arginase [EC:3.5.3.1] [RN:R00551] Urea cycle Organic Nitrogen Amino Acid 0 0 -K01655 homocitrate synthase [EC:2.3.3.14] [RN:R00271] Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K17450 homoaconitase [EC:4.2.1.-] [RN:R03444] Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K01705 homoaconitate hydratase [EC:4.2.1.36] [RN:R04371] Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K05824 homoisocitrate dehydrogenase [EC:1.1.1.87] [RN:R01934] Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K00838 2-aminoadipate transaminase [EC:2.6.1.39] [RN:R01939] Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K00143 L-2-aminoadipate reductase [EC:1.2.1.95] [RN:R03098 R04863 R04390] Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K00293 saccharopine dehydrogenase (NADP+, L-glutamate forming) [EC:1.5.1.10] [RN:R02315] Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K00290 saccharopine dehydrogenase, L-lysine forming [EC:1.5.1.7] [RN:R00715] Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K05827 [lysine-biosynthesis-protein LysW]---L-2-aminoadipate ligase [EC:6.3.2.43] [RN:R09775] Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K05828 LysW-gamma-L-alpha-aminoadipate kinase [EC:2.7.2.-] [RN:R09776] Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K05829 LysW-gamma-L-alpha-aminoadipyl-6-phosphate reductase [EC:1.2.1.-] [RN:R09777] Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K05830 LysW-gamma-L-lysine aminotransferase [EC:2.6.1.-] [RN:R09778] Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K05831 LysW-gamma-L-lysine carboxypeptidase [RN:R09779] Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine Organic Nitrogen Amino Acid 0 0 -K00290 saccharopine dehydrogenase [EC:1.5.1.7] [RN:R00715] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00293 saccharopine dehydrogenase [EC:1.5.1.10] [RN:R02315] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K14157 alpha-aminoadipic semialdehyde synthase [EC:1.5.1.8 1.5.1.9] [RN:R00716 R02313] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K14085 aminoadipate-semialdehyde dehydrogenase [EC:1.2.1.31] [RN:R03102 R03103] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00825 2-aminoadipate transaminase [EC:2.6.1.39] [RN:R01939] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K15791 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 [EC:1.2.4.2] [RN:R01933] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00658 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide [EC:2.3.1.61] [RN:R01933] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [RN:R01933] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00252 glutaryl-CoA dehydrogenase [EC:1.3.8.6] [RN:R02488] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K01825 enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K01782 enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K07514 enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K01692 enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03026] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K07515 enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03026] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K07511 enoyl-CoA hydratase [EC:4.2.1.17] [RN:R03026] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00022 3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35] [RN:R01975] Lysine degradation, lysine => saccharopine => acetoacetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00789 S-adenosylmethionine synthetase [EC:2.5.1.6] [RN:R00177] Methionine degradation Organic Nitrogen Amino Acid 0 0 -K00558 DNA (cytosine-5-)-methyltransferase [EC:2.1.1.37] [RN:R04858] Methionine degradation Organic Nitrogen Amino Acid 0 0 -K17398 DNA (cytosine-5-)-methyltransferase [EC:2.1.1.37] [RN:R04858] Methionine degradation Organic Nitrogen Amino Acid 0 0 -K17399 DNA (cytosine-5-)-methyltransferase [EC:2.1.1.37] [RN:R04858] Methionine degradation Organic Nitrogen Amino Acid 0 0 -K01251 adenosylhomocysteinase [EC:3.3.1.1] [RN:R00192] Methionine degradation Organic Nitrogen Amino Acid 0 0 -K01697 cystathionine beta-synthase [EC:4.2.1.22] [RN:R01290] Methionine degradation Organic Nitrogen Amino Acid 0 0 -K10150 cystathionine beta-synthase [EC:4.2.1.22] [RN:R01290] Methionine degradation Organic Nitrogen Amino Acid 0 0 -K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] [RN:R01090] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00166 2-oxoisovalerate dehydrogenase [EC:1.2.4.4] [RN:R07601 R07602] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00167 2-oxoisovalerate dehydrogenase [EC:1.2.4.4] [RN:R07601 R07602] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K11381 2-oxoisovalerate dehydrogenase [EC:1.2.4.4] [RN:R07601 R07602] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K09699 2-oxoisovalerate dehydrogenase [EC:2.3.1.168] [RN:R04097] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00382 dihydrolipoamide dehydrogenase [EC:1.8.1.4] [RN:R07618] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00253 isovaleryl-CoA dehydrogenase [EC:1.3.99.10] [RN:R04095] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00249 acyl-CoA dehydrogenase [EC:1.3.8.7] [RN:R04095] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K01968 3-methylcrotonyl-CoA carboxylase [EC:6.4.1.4] [RN:R04138] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K01969 3-methylcrotonyl-CoA carboxylase [EC:6.4.1.4] [RN:R04138] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K05607 methylglutaconyl-CoA hydratase [EC:4.2.1.18] [RN:R02085] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K13766 methylglutaconyl-CoA hydratase [EC:4.2.1.18] [RN:R02085] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K01640 hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4] [RN:R01360] Leucine degradation, leucine => acetoacetate + acetyl-CoA Organic Nitrogen Amino Acid 0 0 -K00832 aromatic-amino-acid transaminase [EC:2.6.1.57] [RN:R01731] Tyrosine biosynthesis, prephanate => pretyrosine => tyrosine Organic Nitrogen Amino Acid 0 0 -K15849 aspartate-prephenate aminotransferase [EC:2.6.1.78] [RN:R01731] Tyrosine biosynthesis, prephanate => pretyrosine => tyrosine Organic Nitrogen Amino Acid 0 0 -K00220 cyclohexadienyl dehydrogenase [EC:1.3.1.43] [RN:R00732] Tyrosine biosynthesis, prephanate => pretyrosine => tyrosine Organic Nitrogen Amino Acid 0 0 -K15226 arogenate dehydrogenase (NADP+) [EC:1.3.1.78] [RN:R00733] Tyrosine biosynthesis, prephanate => pretyrosine => tyrosine Organic Nitrogen Amino Acid 0 0 -K15227 arogenate dehydrogenase (NADP+) [EC:1.3.1.78] [RN:R00733] Tyrosine biosynthesis, prephanate => pretyrosine => tyrosine Organic Nitrogen Amino Acid 0 0 -K03334 L-amino-acid oxidase [EC:1.4.3.2] [RN:R00729] Tyrosine degradation, tyrosine => homogentisate Organic Nitrogen Amino Acid 0 0 -K00457 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27] [RN:R02521] Tyrosine degradation, tyrosine => homogentisate Organic Nitrogen Amino Acid 0 0 -K00451 homogentisate 1,2-dioxygenase [EC:1.13.11.5] [RN:R02519] Tyrosine degradation, tyrosine => homogentisate Organic Nitrogen Amino Acid 0 0 -K01800 maleylacetoacetate isomerase [EC:5.2.1.2] [RN:R03181] Tyrosine degradation, tyrosine => homogentisate Organic Nitrogen Amino Acid 0 0 -K01555 fumarylacetoacetase [EC:3.7.1.2] [RN:R01364] Tyrosine degradation, tyrosine => homogentisate Organic Nitrogen Amino Acid 0 0 -K16171 fumarylacetoacetate (FAA) hydrolase [EC:3.7.1.2] [RN:R01364] Tyrosine degradation, tyrosine => homogentisate Organic Nitrogen Amino Acid 0 0 -K01745 histidine ammonia-lyase [EC:4.3.1.3] [RN:R01168] Histidine degradation, histidine => N-formiminoglutamate => glutamate Organic Nitrogen Amino Acid 0 0 -K01712 urocanate hydratase [EC:4.2.1.49] [RN:R02914] Histidine degradation, histidine => N-formiminoglutamate => glutamate Organic Nitrogen Amino Acid 0 0 -K01468 imidazolonepropionase [EC:3.5.2.7] [RN:R02288] Histidine degradation, histidine => N-formiminoglutamate => glutamate Organic Nitrogen Amino Acid 0 0 -K01479 formiminoglutamase [EC:3.5.3.8] [RN:R02285] Histidine degradation, histidine => N-formiminoglutamate => glutamate Organic Nitrogen Amino Acid 0 0 -K00603 glutamate formiminotransferase [EC:2.1.2.5] [RN:R02287] Histidine degradation, histidine => N-formiminoglutamate => glutamate Organic Nitrogen Amino Acid 0 0 -K13990 glutamate formiminotransferase [EC:2.1.2.5] [RN:R02287] Histidine degradation, histidine => N-formiminoglutamate => glutamate Organic Nitrogen Amino Acid 0 0 -K05603 formimidoylglutamate deiminase [EC:3.5.3.13] [RN:R02286] Histidine degradation, histidine => N-formiminoglutamate => glutamate Organic Nitrogen Amino Acid 0 0 -K01458 N-formylglutamate deformylase [EC:3.5.1.68] [RN:R00525] Histidine degradation, histidine => N-formiminoglutamate => glutamate Organic Nitrogen Amino Acid 0 0 -K00207 dihydropyrimidine dehydrogenase (NADP+) [EC:1.3.1.2] [RN:R00978 R01415] Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate Organic Nitrogen Amino Acid 0 0 -K17722 dihydropyrimidine dehydrogenase (NAD+) [EC:1.3.1.1] [RN:R00977 R11026] Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate Organic Nitrogen Amino Acid 0 0 -K17723 dihydropyrimidine dehydrogenase (NAD+) [EC:1.3.1.1] [RN:R00977 R11026] Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate Organic Nitrogen Amino Acid 0 0 -K01464 dihydropyrimidinase [EC:3.5.2.2] [RN:R02269 R03055] Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate Organic Nitrogen Amino Acid 0 0 -K01431 beta-ureidopropionase [EC:3.5.1.6] [RN:R00905 R04666] Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate Organic Nitrogen Amino Acid 0 0 -K06016 beta-ureidopropionase [EC:3.5.1.6] [RN:R00905 R04666] Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate Organic Nitrogen Amino Acid 0 0 -K01649 2-isopropylmalate synthase [EC:2.3.3.13] [RN:R01213] Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate Organic Nitrogen Amino Acid 0 0 -K01702 3-isopropylmalate dehydratase [EC:4.2.1.33] [RN:R03968 R04001] Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate Organic Nitrogen Amino Acid 0 0 -K01703 3-isopropylmalate dehydratase [EC:4.2.1.33] [RN:R03968 R04001] Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate Organic Nitrogen Amino Acid 0 0 -K01704 3-isopropylmalate dehydratase [EC:4.2.1.33] [RN:R03968 R04001] Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate Organic Nitrogen Amino Acid 0 0 -K00052 3-isopropylmalate dehydrogenase [EC:1.1.1.85] [RN:R04426] Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate Organic Nitrogen Amino Acid 0 0 -K01655 homocitrate synthase [EC:2.3.3.14] [RN:R00271] Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate Organic Nitrogen Amino Acid 0 0 -K17450 homoaconitase [EC:4.2.1.- 4.2.1.36 4.2.1.114] [RN:R03444 R04371 R09720] Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate Organic Nitrogen Amino Acid 0 0 -K01705 homoaconitase [EC:4.2.1.- 4.2.1.36 4.2.1.114] [RN:R03444 R04371 R09720] Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate Organic Nitrogen Amino Acid 0 0 -K16792 homoaconitase [EC:4.2.1.- 4.2.1.36 4.2.1.114] [RN:R03444 R04371 R09720] Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate Organic Nitrogen Amino Acid 0 0 -K16793 homoaconitase [EC:4.2.1.- 4.2.1.36 4.2.1.114] [RN:R03444 R04371 R09720] Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate Organic Nitrogen Amino Acid 0 0 -K05824 homoisocitrate dehydrogenase [EC:1.1.1.87] [RN:R01934] Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate Organic Nitrogen Amino Acid 0 0 -K00928 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [RN:R02291] Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01714 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] [RN:R10147] Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00215 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] [RN:R04198 R04199] Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K05822 tetrahydrodipicolinate N-acetyltransferase [EC:2.3.1.89] [RN:R04364] Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00841 aminotransferase [EC:2.6.1.-] [RN:R04467] Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K05823 N-acetyldiaminopimelate deacetylase [EC:3.5.1.47] [RN:R02733] Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01778 diaminopimelate epimerase [EC:5.1.1.7] [RN:R02735] Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01586 diaminopimelate decarboxylase [EC:4.1.1.20] [RN:R00451] Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00928 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K12524 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K12525 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K12526 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [RN:R02291] Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01714 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] [RN:R10147] Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00215 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] [RN:R04198 R04199] Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K03340 diaminopimelate dehydrogenase [EC:1.4.1.16] [RN:R02755] Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01586 diaminopimelate decarboxylase [EC:4.1.1.20] [RN:R00451] Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00928 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K12524 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K12525 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K12526 aspartate kinase [EC:2.7.2.4] [RN:R00480] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00133 aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] [RN:R02291] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01714 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] [RN:R10147] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K00215 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] [RN:R04198 R04199] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K10206 LL-diaminopimelate aminotransferase [EC:2.6.1.83] [RN:R07613] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01778 diaminopimelate epimerase [EC:5.1.1.7] [RN:R02735] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K01586 diaminopimelate decarboxylase [EC:4.1.1.20] [RN:R00451] Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine Organic Nitrogen Amino Acid 0 0 -K09011 cimA; D-citramalate synthase [EC:2.3.1.182] [RN:R07399] Isoleucine biosynthesis, pyruvate => 2-oxobutanoate Organic Nitrogen Amino Acid 0 0 -K01703 leuCD; 3-isopropylmalate/(R)-2-methylmalate dehydratase [EC:4.2.1.33 4.2.1.35] [RN:R03896 R03898] Isoleucine biosynthesis, pyruvate => 2-oxobutanoate Organic Nitrogen Amino Acid 0 0 -K01704 leuCD; 3-isopropylmalate/(R)-2-methylmalate dehydratase [EC:4.2.1.33 4.2.1.35] [RN:R03896 R03898] Isoleucine biosynthesis, pyruvate => 2-oxobutanoate Organic Nitrogen Amino Acid 0 0 -K00052 leuB; 3-isopropylmalate dehydrogenase [EC:1.1.1.85] [RN:R00994] Isoleucine biosynthesis, pyruvate => 2-oxobutanoate Organic Nitrogen Amino Acid 0 0 -K17755 choline oxidase [EC:1.1.3.17] [R01022 R08211] Betaine biosynthesis, choline => betaine Organic Nitrogen Amino Acid 0 0 -K00108 choline dehydrogenase [EC:1.1.99.1] [RN:R01025 R08557 R08558] Betaine biosynthesis, choline => betaine Organic Nitrogen Amino Acid 0 0 -K11440 choline dehydrogenase [EC:1.1.99.1] [RN:R01025 R08557 R08558] Betaine biosynthesis, choline => betaine Organic Nitrogen Amino Acid 0 0 -K00130 betaine-aldehyde dehydrogenase [EC:1.2.1.8] [R02565 R02566] Betaine biosynthesis, choline => betaine Organic Nitrogen Amino Acid 0 0 -K17989 threonine dehydratase [EC:4.3.1.19] [RN:R00996] Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K01754 threonine dehydratase [EC:4.3.1.19] [RN:R00996] Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K01652 acetolactate synthase [EC:2.2.1.6] [RN:R08648] Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K01653 acetolactate synthase [EC:2.2.1.6] [RN:R08648] Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K11258 acetolactate synthase [EC:2.2.1.6] [RN:R08648] Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K00053 ketol-acid reductoisomerase [EC:1.1.1.86] [RN:R05069 R05068] Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K01687 dihydroxy-acid dehydratase [EC:4.2.1.9] [RN:R05070] Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K00826 branched-chain amino acid aminotransferase [EC:2.6.1.42] [RN:R02199] Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine Organic Nitrogen Amino Acid 0 0 -K01647 citrate synthase [EC:2.3.3.1] [RN:R00351] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K01681 aconitate hydratase [EC:4.2.1.3] [RN:R01325 R01900] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K00031 isocitrate dehydrogenase [EC:1.1.1.42] [RN:R01899 R00268] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K00261 glutamate dehydrogenase (NAD(P)+) [EC:1.4.1.3] [RN:R00248] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K19268 methylaspartate mutase epsilon subunit [EC:5.4.99.1] [RN:R00262] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K01846 methylaspartate mutase epsilon subunit [EC:5.4.99.1] [RN:R00262] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K04835 methylaspartate ammonia-lyase [EC:4.3.1.2] [RN:R03696] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K19280 succinyl-CoA:mesaconate CoA transferase [EC:2.8.3.-] [RN:R10904] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K14449 2-methylfumaryl-CoA hydratase [EC:4.2.1.148] [RN:R05076] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K19281 beta-methylmalyl-CoA/(S)-malyl-CoA lyase [EC:4.1.3.24] [RN:R00934] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K19282 bifunctional (S)-malyl-CoA lyase/thioesterase [EC:4.1.3.24 3.1.2.30] [RN:R00473 R10612] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K00024 malate dehydrogenase [EC:1.1.1.37] [RN:R00342] Methylaspartate cycle Organic Nitrogen Amino Acid 0 0 -K19412 glutamate--LysW ligase ArgX [EC:6.3.2.-] [RN:R10929] Ornithine biosynthesis, mediated by LysW, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K05828 LysW-L-glutamate kinase [EC:2.7.2.-] [RN:R10930] Ornithine biosynthesis, mediated by LysW, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K05829 LysW-L-glutamyl-5-phosphate reductase [EC:1.2.1.-] [RN:R10931] Ornithine biosynthesis, mediated by LysW, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K05830 LysW-L-ornithine aminotransferase [EC:2.6.1.-] [RN:R10932] Ornithine biosynthesis, mediated by LysW, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -K05831 LysW-L-ornithine carboxypeptidase [RN:R10933] Ornithine biosynthesis, mediated by LysW, glutamate => ornithine Organic Nitrogen Amino Acid 0 0 -A02H Catlytic type: Aspartate; maximally active in the range pH 4-6 Endopeptidases Organic Nitrogen Peptidase 0 0 -A02G Catlytic type: Aspartate; maximally active in the range pH 4-6 Endopeptidases Organic Nitrogen Peptidase 0 0 -A02F Catlytic type: Aspartate; maximally active in the range pH 4-6 Endopeptidases Organic Nitrogen Peptidase 0 0 -A02E Catlytic type: Aspartate; maximally active in the range pH 4-6 Endopeptidases Organic Nitrogen Peptidase 0 0 -A02D Catlytic type: Aspartate; maximally active in the range pH 4-6 Endopeptidases Organic Nitrogen Peptidase 0 0 -A02C Catlytic type: Aspartate; maximally active in the range pH 4-6 Endopeptidases Organic Nitrogen Peptidase 0 0 -A02B Catlytic type: Aspartate; maximally active in the range pH 4-6 Endopeptidases Organic Nitrogen Peptidase 0 0 -A02A Catlytic type: Aspartate; maximally active in the range pH 4-6 Endopeptidases Organic Nitrogen Peptidase 0 0 -A03B Catlytic type: Aspartate; Several cleavage sites are thought to exist; The peptidases in family A3 are the polyprotein-processing endopeptidases of the pararetroviruses; LeuAla cleavage site found within a highly hydrophobic region has been identified for one member Endopeptidases Organic Nitrogen Peptidase 0 0 -A03A Catlytic type: Aspartate; Several cleavage sites are thought to exist; The peptidases in family A3 are the polyprotein-processing endopeptidases of the pararetroviruses; LeuAla cleavage site found within a highly hydrophobic region has been identified for one member Endopeptidases Organic Nitrogen Peptidase 0 0 -A11B Catlytic type: Aspartate; performs all the cleavages that occur in the polyproteins; initial cleavage in the Gag-Pol polyprotein exposes the N-terminus of the endopeptidase and is an essential prerequisite for the other cleavages to occur Endopeptidases involved in the processing of polyproteins encoded by retrotransposons Organic Nitrogen Peptidase 0 0 -A11A Catlytic type: Aspartate; performs all the cleavages that occur in the polyproteins; initial cleavage in the Gag-Pol polyprotein exposes the N-terminus of the endopeptidase and is an essential prerequisite for the other cleavages to occur Endopeptidases involved in the processing of polyproteins encoded by retrotransposons Organic Nitrogen Peptidase 0 0 -A22B Catlytic type: Aspartate; See Additional Information; Functional in Alzheimer's disease; Beta peptides are derived from an internal segment (about 42 amino acids) of the large Alzheimers precursor protein that is excised by peptidase activities known as 'beta-secretase' (cleaving at the N-terminus of the beta-peptide) and 'gamma-secretase' (cleaving at the C-terminus). The gamma-secretase cleavage occurs in a transmembrane segment of the APP, and is mediated by presenilin in complex with nicastrin, APH-1 and PEN-2. A third activity termed 'alpha-secretase' degrades the beta-peptide, making it harmless. More than one individual peptidase may be responsible for each of the secretase activities. Membrane-inserted endopeptidases Organic Nitrogen Peptidase 0 0 -A22A Catlytic type: Aspartate; See Additional Information; Functional in Alzheimer's disease; Beta peptides are derived from an internal segment (about 42 amino acids) of the large Alzheimers precursor protein that is excised by peptidase activities known as 'beta-secretase' (cleaving at the N-terminus of the beta-peptide) and 'gamma-secretase' (cleaving at the C-terminus). The gamma-secretase cleavage occurs in a transmembrane segment of the APP, and is mediated by presenilin in complex with nicastrin, APH-1 and PEN-2. A third activity termed 'alpha-secretase' degrades the beta-peptide, making it harmless. More than one individual peptidase may be responsible for each of the secretase activities. Membrane-inserted endopeptidases Organic Nitrogen Peptidase 0 0 -A33 Catlytic type: Aspartate Endopeptidases Organic Nitrogen Peptidase 0 0 -C01B Catlytic type: Cysteine; Dominant specificity subsite in most of the peptidases of subfamily C1A is S2; Family C1 peptidases contribute proteolytic activity to the digestive vacuoles of protozoa and to the lysosomal system of eukaryotic cells Many endopeptidases and a few exopeptidases Organic Nitrogen Peptidase 0 0 -C01A Catlytic type: Cysteine; Dominant specificity subsite in most of the peptidases of subfamily C1A is S2; Family C1 peptidases contribute proteolytic activity to the digestive vacuoles of protozoa and to the lysosomal system of eukaryotic cells Many endopeptidases and a few exopeptidases Organic Nitrogen Peptidase 0 0 -C02B Catlytic type: Cysteine; hydrophobic residues (Tyr, Met, Leu, Val) and also Arg tend to be found in the P2 position; dependent on neutral pH Endopeptidases termed calpains Organic Nitrogen Peptidase 0 0 -C02A Catlytic type: Cysteine; hydrophobic residues (Tyr, Met, Leu, Val) and also Arg tend to be found in the P2 position; dependent on neutral pH Endopeptidases termed calpains Organic Nitrogen Peptidase 0 0 -C03H Catlytic type: Cysteine; Bonds cleaved in processing the viral polyprotein are commonly -Gln-Gly- Endopeptidases of RNA viruses Organic Nitrogen Peptidase 0 0 -C03G Catlytic type: Cysteine; Bonds cleaved in processing the viral polyprotein are commonly -Gln-Gly- Endopeptidases of RNA viruses Organic Nitrogen Peptidase 0 0 -C03F Catlytic type: Cysteine; Bonds cleaved in processing the viral polyprotein are commonly -Gln-Gly- Endopeptidases of RNA viruses Organic Nitrogen Peptidase 0 0 -C03E Catlytic type: Cysteine; Bonds cleaved in processing the viral polyprotein are commonly -Gln-Gly- Endopeptidases of RNA viruses Organic Nitrogen Peptidase 0 0 -C03D Catlytic type: Cysteine; Bonds cleaved in processing the viral polyprotein are commonly -Gln-Gly- Endopeptidases of RNA viruses Organic Nitrogen Peptidase 0 0 -C03C Catlytic type: Cysteine; Bonds cleaved in processing the viral polyprotein are commonly -Gln-Gly- Endopeptidases of RNA viruses Organic Nitrogen Peptidase 0 0 -C03B Catlytic type: Cysteine; Bonds cleaved in processing the viral polyprotein are commonly -Gln-Gly- Endopeptidases of RNA viruses Organic Nitrogen Peptidase 0 0 -C03A Catlytic type: Cysteine; Bonds cleaved in processing the viral polyprotein are commonly -Gln-Gly- Endopeptidases of RNA viruses Organic Nitrogen Peptidase 0 0 -C04 Catlytic type: Cysteine; cleavage of GlnGly bonds in the processing of the viral polyprotein Cysteine endopeptidases of viruses Organic Nitrogen Peptidase 0 0 -C05 Catlytic type: Cysteine; cleaves Xaa-Xbb-Gly-Xbb-Xbb type bonds, where Xaa is Met, Leu or Ile and Xbb is any amino acid ; processes the virus protein precursors by removing an N-terminal propeptide Endopeptidase adenain Organic Nitrogen Peptidase 0 0 -C06 Catlytic type: Cysteine; cleavage site is -Tyr-Xaa-GlyGly-; serves a function in viral infectivity Cysteine endopeptidases of RNA viruses Organic Nitrogen Peptidase 0 0 -C07 Catlytic type: Cysteine; cleaves a single Gly|+|Gly bond; p29 peptidase is autocatylitically released during translation from the small polyprotein of the virus Contains only the p29 peptidase from chestnut blight hypovirus Organic Nitrogen Peptidase 0 0 -C08 Catlytic type: Cysteine; cleaves of a single Gly-Ala bond; p48 endopeptidase is autocatylitically released from the small polyprotein Contains only the p48 proteinase of the chestnut blight hypovirus Organic Nitrogen Peptidase 0 0 -C09 Catlytic type: Cysteine; cleaves at (Ala/Ile)-Gly-(Ala/Cys/Gly)(Ala/Tyr) site in the viral nonstructural polyproteins Viral cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -C104 Catlytic type: Cysteine; cleaves the cell wall cross-linking peptide between D-Ala and Ala ; can cross epithelial cell membranes Cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -C105 Catlytic type: Cysteine; Processing of polyprotein occurs at two glycyl bonds Polyprotein-processing cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -C107 Catlytic type: Cysteine; preference for Asn in P2 and cleaves the polyprotein at two sites Polyprotein processing cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -C108 Catlytic type: Cysteine; important for processing the N-terminal extension of ribosomal protein L27 Prp peptidase Organic Nitrogen Peptidase 0 0 -C113 Catlytic type: Cysteine; member is IgdE peptidase IgdE peptidase Organic Nitrogen Peptidase 0 0 -C14B Catlytic type: Cysteine; All the peptidases of family C14 have a strict requirement for the amino acid in P1 to be aspartate, however the substrate specificities of the individual caspases are distinct and determined by the residues present in the pockets of P2, P3 and P4.; caspases that have strict specificity for the hydrolysis of aspartyl bonds Cytosolic endopeptidases termed caspases that have strict specificity for the hydrolysis of aspartyl bonds Organic Nitrogen Peptidase 0 0 -C14A Catlytic type: Cysteine; All the peptidases of family C14 have a strict requirement for the amino acid in P1 to be aspartate, however the substrate specificities of the individual caspases are distinct and determined by the residues present in the pockets of P2, P3 and P4.; caspases that have strict specificity for the hydrolysis of aspartyl bonds Cytosolic endopeptidases termed caspases that have strict specificity for the hydrolysis of aspartyl bonds Organic Nitrogen Peptidase 0 0 -C16B Catlytic type: Cysteine; requirement for Phe in P6 in PLP2; Papain-like proteinase 1 and papain-like proteinase are both members of family C16 Polyprotein processing endopeptidases from coronaviruses Organic Nitrogen Peptidase 0 0 -C16A Catlytic type: Cysteine; a requirement for Arg or Lys in P5; Papain-like proteinase 1 and papain-like proteinase are both members of family C16 Polyprotein processing endopeptidases from coronaviruses Organic Nitrogen Peptidase 0 0 -C18 Catlytic type: Cysteine; cleaves at the 2/3 site; may be an essential step in the replication of hepatitis C virus Viral cysteine endopeptidase Organic Nitrogen Peptidase 0 0 -C19 Catlytic type: Cysteine; hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin; intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds Ubiquitinyl hydrolases Organic Nitrogen Peptidase 0 0 -C21 Catlytic type: Cysteine; cleavage of the 206-kDa polyprotein occurs in cis at a Ala-Thr bond; involved in the proteolytic maturation of turnip yellow mosaic virus (TYMV) Polyprotein processing endopeptidases from the single-stranded RNA viruses related to turnip yellow mosaic virus (tymoviruses) Organic Nitrogen Peptidase 0 0 -C23 Catlytic type: Cysteine; leave in cis but not in trans, and an Ala-Asp cleavage site; peptidases of the family are necessary for the processing of the carlavirus polyproteins Cysteine endopeptidases of single-stranded RNA viruses Organic Nitrogen Peptidase 0 0 -C24 Catlytic type: Cysteine; substrate is the viral polyprotein with the majority of the identified cleavage sites being Glu in P1, and the remainder, Gln; P1 residue is commonly Gly; refers to single-stranded RNA viruses Cysteine endopeptidases of single-stranded RNA viruses Organic Nitrogen Peptidase 0 0 -C26 Catlytic type: Cysteine; gamma-linked glutamate bonds Omega peptidase gamma-glutamyl hydrolase Organic Nitrogen Peptidase 0 0 -C27 Catlytic type: Cysteine; processes the non-structural polyprotein at Gly1300-Gly1301; non-structural polyprotein processing endopeptidase from the rubella virus Non-structural polyprotein processing endopeptidase from the rubella virus Organic Nitrogen Peptidase 0 0 -C28 Catlytic type: Cysteine; cleaves the host initiation factor eIF-4G firstly at Gly479-Arg480 and then at Lys318-Arg319; processing of viral polyprotein Viral processing endopeptidases Organic Nitrogen Peptidase 0 0 -C30 Catlytic type: Cysteine; requirement for Gln at position P1;P1 may be occupied by small aliphatic residues; P2 Leu is usually found, but may be Ile, Tyr, Val, Phe or Met; P4 may contain Val, Ala, Ser or Tyr; processing of viral polyprotein Endopeptidases from coronaviruses Organic Nitrogen Peptidase 0 0 -C31 Catlytic type: Cysteine; cleaves the polyprotein C-terminal to the catalytic His, producing a 20- to 22-kDa product Polyprotein processing endopeptidases from viruses Organic Nitrogen Peptidase 0 0 -C32 Catlytic type: Cysteine; cleaves a Gly-Gly bond just C-terminal to the active site His residue Polyprotein-processing peptidase of arteriviruses, papain-like cysteine proteinase beta (PCP beta) Organic Nitrogen Peptidase 0 0 -C33 Catlytic type: Cysteine; cleaves between two Gly residues Viral polyprotein-processing endopeptidase Organic Nitrogen Peptidase 0 0 -C36 Catlytic type: Cysteine; cleaves between the helicase and polymerase domains and is predicted to be 600 amino acids from the C-terminus of the protein Putative papain-like peptidase Organic Nitrogen Peptidase 0 0 -C37 Catlytic type: Cysteine; P1 residues in the cleavage sites are commonly Glu or Gln; responsible for all of the processing reactions in the ORF1 polyproteins of the caliciviruses Calicivirin, a polyprotein-processing endopeptidases known from caliciviruses Organic Nitrogen Peptidase 0 0 -C39 Catlytic type: Cysteine; cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins Bacteriocin-processing endopeptidases from bacteria Organic Nitrogen Peptidase 0 0 -C40 Catlytic type: Cysteine; hydrolyses substrates of the general structure L-Ala-gamma-D-GluL-Zaa-Yaa, in which Zaa is a di-amino acid such as L-lysine or diaminopimelic acid, and Yaa is D-Ala or D-Ala-D-Ala; expressed during sporulation, and is responsible for the degradation of bacterial cell wall components Bacterial cell-wall modifying enzymes Organic Nitrogen Peptidase 0 0 -C42 Catlytic type: Cysteine; cleaves a single Gly-Gly bond, releasing the N-terminal 66 kDa leader protein, which includes the peptidase; peptidase releases the N-terminal protein from the viral polyprotein Polyprotein processing endopeptidases from closteroviruses Organic Nitrogen Peptidase 0 0 -C44 Catlytic type: Cysteine; the only known peptidase activity is the autolytic cleavage of the amidophosphoribosyltransferase precursor protein Self-processing precursor of amidophosphoribosyltransferase Organic Nitrogen Peptidase 0 0 -C46 Catlytic type: Cysteine; autolytic cleavage occurs at a conserved -Gly-Cys- bond, and is mediated by the C-terminal domain of the hedgehog protein C-terminal, intein-like domains of the hedgehog proteins, which mediate autolytic cleavage of the proteins Organic Nitrogen Peptidase 0 0 -C48 Catlytic type: Cysteine; demonstrates dual enzymic activity different to most deubiquitinating enzymes SUMO (small ubiquitin-like modifier) deconjugating enzymes Organic Nitrogen Peptidase 0 0 -C49 Catlytic type: Cysteine Strawberry mottle virus 3C-like peptidase Organic Nitrogen Peptidase 0 0 -C51 Catlytic type: Cysteine; bacteriophage phi11 cleaves the crosslinking peptide of the host at the D-Ala-Gly bond Endopeptidases that hydrolyse bacterial cell-wall crosslinking peptides Organic Nitrogen Peptidase 0 0 -C53 Catlytic type: Cysteine; releases itself from the N-terminus of the p20 polyprotein by an autolytic cleavage of the Cys168-Gly bond in cys; processing of viral polyprotein Endopeptidases that process the {Pestivirus} p20 polyprotein Organic Nitrogen Peptidase 0 0 -C57 Catlytic type: Cysteine; P4b and P25K proteins are cleaved within an AlaGly-Ala motif, and AlaGly-Ser motif for P4a only; processing of smallpox viral protein Endopeptidases that process the precursors of viral proteins Organic Nitrogen Peptidase 0 0 -C59 Catlytic type: Cysteine; autolytic cleavage of the penicillin V acylase precursor protein Cys-dependent Ntn-hydrolases Organic Nitrogen Peptidase 0 0 -C60B Catlytic type: Cysteine; consensus cleavage site is NPQT-N; catalyzes the formation of an amide bond between the new C-terminal Thr and a cell wall pentaglycine cross-bridge Bacterial peptidases with strong transferase activity Organic Nitrogen Peptidase 0 0 -C60A Catlytic type: Cysteine; consensus cleavage site is LPXT-G; catalyzes the formation of an amide bond between the new C-terminal Thr and a cell wall pentaglycine cross-bridge Bacterial peptidases with strong transferase activity Organic Nitrogen Peptidase 0 0 -C62 Catlytic type: Cysteine; cleavage consensus site has been defined as -Val-Xaa-His-GluYaa, in which Yaa is Leu or Val; predicted to be the key enzyme in the processing of the GAV replicase polyprotein precursors, pp1a and pp1ab Viral polyprotein-processing endopeptidase Organic Nitrogen Peptidase 0 0 -C63 Catlytic type: Cysteine; cleaves at -GlyGly-Xaa- sites to produce six major structural components of mature virions; required for the maturation of the virus (e.g. African swine fever virus) Endopeptidases Organic Nitrogen Peptidase 0 0 -C71 Endopeptidases that cleave crosslinking peptides of the archaean cell wall Endopeptidases that cleave crosslinking peptides of the archaean cell wall Organic Nitrogen Peptidase 0 0 -C74 Catlytic type: Cysteine; cleavage between NS2 and NS3 of the viral polyprotein, a cleavage that is correlated with cytopathogenicity ; Contributes to maturation of the viral polyprotein Viral self-processing peptidases Organic Nitrogen Peptidase 0 0 -C76 Catlytic type: Cysteine; releases of ubiquitin from proteins ubiquitinylated via Lys48; enzymes from herpes simplex virus Ubiquitinyl hydrolases Organic Nitrogen Peptidase 0 0 -C85B Catlytic type: Cysteine; cleaved the lysine-63-linked polyubiquitin chains on tumor necrosis factor receptor-associated factor 3 Deubiquitinylating peptidases Organic Nitrogen Peptidase 0 0 -C85A Catlytic type: Cysteine; cleaved the lysine-63-linked polyubiquitin chains on tumor necrosis factor receptor-associated factor 3 Deubiquitinylating peptidases Organic Nitrogen Peptidase 0 0 -C87 Catlytic type: Cysteine; deubiquitinylase and deISGylase activities Viral isopeptidases Organic Nitrogen Peptidase 0 0 -C89 Catlytic type: Cysteine Self-cleaving precursor protein Organic Nitrogen Peptidase 0 0 -C97 Catlytic type: Cysteine; localize in the cytoplasm SUMO (small ubiquitin-like modifier) deconjugating enzymes Organic Nitrogen Peptidase 0 0 -C99 Catlytic type: Cysteine; releases itself from the viral polyprotein and cleavage occurs in trans; processes the viral polyprotein, releasing proteins that are essential for maturation of the virus Endopeptidases from RNA viruses Organic Nitrogen Peptidase 0 0 -G02 Catlytic type: Glutamate; Self-cleavage is important for correct assembly of the viral appendages Self-cleaving endopeptidases Organic Nitrogen Peptidase 0 0 -I02 Inhibitors of serine peptidases Inhibitors of serine peptidases Organic Nitrogen Peptidase 0 0 -I04 Inhibitors of serine and cysteine endopeptidases Inhibitors of serine and cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -I08 Inhibitors of serine and metallo endopeptidases Inhibitors of serine and metallo endopeptidases Organic Nitrogen Peptidase 0 0 -I24 Inhibitors of serine endopeptidases from family S16 Inhibitors of serine endopeptidases from family S16 Organic Nitrogen Peptidase 0 0 -I25C inhibit peptidases of family S8 and M12, but not C1 Inhibitors primarily of the papain-like cysteine peptidases in family C1 Organic Nitrogen Peptidase 0 0 -I25B inhibit peptidases of mostly C1 and also some legumain (family C13) Inhibitors primarily of the papain-like cysteine peptidases in family C1 Organic Nitrogen Peptidase 0 0 -I25A inhibit peptidases of family C1 Inhibitors primarily of the papain-like cysteine peptidases in family C1 Organic Nitrogen Peptidase 0 0 -I29 Inhibitors of cysteine peptidases from family C1 Inhibitors of cysteine peptidases from family C1 Organic Nitrogen Peptidase 0 0 -I32 Inhibitors of caspases, cysteine endopeptidases from family C14 Inhibitors of caspases, cysteine endopeptidases Organic Nitrogen Peptidase 0 0 -I36 Inhibitor of metalloendopeptidases in family M4 Inhibitor of metalloendopeptidases Organic Nitrogen Peptidase 0 0 -I43 Inhibitors of metallopeptidases from family M12 Inhibitors of metallopeptidases from family M12 Organic Nitrogen Peptidase 0 0 -I50B inhibits human caspase; In general, I50 inhibitors facilitate the replication of baculoviruses in their hosts by blocking the apoptosis of the cells that would normally follow viral infection. Capsases, peptidases in family C14 Organic Nitrogen Peptidase 0 0 -I50A inhibits human caspase; In general, I50 inhibitors facilitate the replication of baculoviruses in their hosts by blocking the apoptosis of the cells that would normally follow viral infection. Capsases, peptidases in family C14 Organic Nitrogen Peptidase 0 0 -I51 Inhibitor of serine carboxypeptidase Y and some members of the S1 family Inhibitor of serine carboxypeptidase Y Organic Nitrogen Peptidase 0 0 -I63 Inhibitor of the metallopeptidase pappalysin-1; Pappalysin-1 promotes cell growth by the cleavage of insulin-like growth factor binding proteins-4 and -5, causing the release of bound insulin-like growth factors Inhibitor of the metallopeptidase pappalysin-1 Organic Nitrogen Peptidase 0 0 -I75 Inhibitors of metallo-endopeptidases; contains bacteriophage lambda CIII protein, which helps push the phage towards the lysogenic mode of phage development Inhibitors of metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -I87 Inhibitors, specificity unknown; HflC (Escherichia coli); The factor that influences bacteriophage lambda to remain in the lysogenic stage or to lyse the host cell is transcription factor CII. Degradation of CII by the host FtsH peptidase promotes lysis Inhibitors, specificity unknown Organic Nitrogen Peptidase 0 0 -I91 Inhibitors of caspase-9; prevents activation of the executor caspases in the mitochondrial cell death pathway, thereby preventing apoptosis and destruction of the cell in which the virus is being propagated Inhibitors of caspase-9 Organic Nitrogen Peptidase 0 0 -M03C Catlytic type: Metallo; cleave near C-terminus of substrates with low molecule mass (generally less than 19 residues) Metallopeptidases with varied activities Organic Nitrogen Peptidase 0 0 -M03B Catlytic type: Metallo; cleave near C-terminus of substrates with low molecule mass (generally less than 19 residues) Metallopeptidases with varied activities Organic Nitrogen Peptidase 0 0 -M03A Catlytic type: Metallo; cleave near C-terminus of substrates with low molecule mass (generally less than 19 residues) Metallopeptidases with varied activities Organic Nitrogen Peptidase 0 0 -M10C Catlytic type: Metallo; mostly secreted proteins that function extracellularly Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M10B Catlytic type: Metallo; mostly secreted proteins that function extracellularly Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M10A Catlytic type: Metallo; mostly secreted proteins that function extracellularly Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M12C Catlytic type: Metallo; shown to have specificity for -Xaa-Asp- bond, but in general have much broader specificities; occur as proenzymes that require activation by limited proteolysis Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M12B Catlytic type: Metallo; shown to have specificity for -Xaa-Asp- bond, but in general have much broader specificities; occur as proenzymes that require activation by limited proteolysis Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M12A Catlytic type: Metallo; shown to have specificity for -Xaa-Asp- bond, but in general have much broader specificities; occur as proenzymes that require activation by limited proteolysis Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M13 Catlytic type: Metallo; cleaves Trp-Val/Ile bond in the 'big endothelin' precursors of endothelin 1 Metalloendopeptidases restricted to action on substrates smaller than proteins Organic Nitrogen Peptidase 0 0 -M14C Catlytic type: Metallo; hydrolyse single, C-terminal amino acids from polypeptide chains; shown to be involved in bacterial cell wall metabolism Metallocarboxypeptidases Organic Nitrogen Peptidase 0 0 -M14D Catlytic type: Metallo; hydrolyse single, C-terminal amino acids from polypeptide chains Metallocarboxypeptidases Organic Nitrogen Peptidase 0 0 -M14B Catlytic type: Metallo; hydrolyse single, C-terminal amino acids from polypeptide chains (prefers basic amino acids) Metallocarboxypeptidases Organic Nitrogen Peptidase 0 0 -M14A Catlytic type: Metallo; hydrolyse single, C-terminal amino acids from polypeptide chains (prefers aromatic or branched side chains) Metallocarboxypeptidases Organic Nitrogen Peptidase 0 0 -M15D Catlytic type: Metallo; substrates of the type Xaa-YaaZaa, with blocked amino terminus and free C-terminus ; involved in bacterial cell wall biosynthesis and metabolism Metallopeptidases, mostly specialised carboxypeptidases and dipeptidases Organic Nitrogen Peptidase 0 0 -M15C Catlytic type: Metallo; substrates of the type Xaa-YaaZaa, with blocked amino terminus and free C-terminus ; involved in bacterial cell wall biosynthesis and metabolism Metallopeptidases, mostly specialised carboxypeptidases and dipeptidases Organic Nitrogen Peptidase 0 0 -M15B Catlytic type: Metallo; substrates of the type Xaa-YaaZaa, with blocked amino terminus and free C-terminus ; involved in bacterial cell wall biosynthesis and metabolism Metallopeptidases, mostly specialised carboxypeptidases and dipeptidases Organic Nitrogen Peptidase 0 0 -M15A Catlytic type: Metallo; substrates of the type Xaa-YaaZaa, with blocked amino terminus and free C-terminus ; involved in bacterial cell wall biosynthesis and metabolism Metallopeptidases, mostly specialised carboxypeptidases and dipeptidases Organic Nitrogen Peptidase 0 0 -M16C Catlytic type: Metallo; specificities are varied, but the site of cleavage is seldom far from a terminus of the substrate molecule and often include cleavage of Xaa-Arg bonds; inhibited by chelating agents Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M16B Catlytic type: Metallo; specificities are varied, but the site of cleavage is seldom far from a terminus of the substrate molecule and often include cleavage of Xaa-Arg bonds; inhibited by chelating agents Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M16A Catlytic type: Metallo; specificities are varied, but the site of cleavage is seldom far from a terminus of the substrate molecule and often include cleavage of Xaa-Arg bonds; inhibited by chelating agents Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M20E Catlytic type: Metallo Exopeptidases: carboxypeptidases, dipeptidases and a specialised aminopeptidase Organic Nitrogen Peptidase 0 0 -M20A Catlytic type: Metallo; glutamate carboxypeptidase Exopeptidases: carboxypeptidases, dipeptidases and a specialised aminopeptidase Organic Nitrogen Peptidase 0 0 -M20D Catlytic type: Metallo; broad specificity; generally found in archaea Exopeptidases: carboxypeptidases, dipeptidases and a specialised aminopeptidase Organic Nitrogen Peptidase 0 0 -M20F Catlytic type: Metallo; non-specific dipeptidase ; eukaryotic Exopeptidases: carboxypeptidases, dipeptidases and a specialised aminopeptidase Organic Nitrogen Peptidase 0 0 -M20B Catlytic type: Metallo; acts only on tripeptide substrates; also known as tripeptidases Exopeptidases: carboxypeptidases, dipeptidases and a specialised aminopeptidase Organic Nitrogen Peptidase 0 0 -M20C Catlytic type: Metallo; Xaa-His dipeptidase; also known as carnosinases Exopeptidases: carboxypeptidases, dipeptidases and a specialised aminopeptidase Organic Nitrogen Peptidase 0 0 -M23B Catlytic type: Metallo; cleaves either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptideor a bond within the cross-linking peptide (e.g. stapholysin), with preference for Gly bonds; used by certain bacteria to lyse cell walls of other bacteria, either as a defensive or feeding mechanism Endopeptidases that lyse bacterial cell wall peptidoglycans Organic Nitrogen Peptidase 0 0 -M23A Catlytic type: Metallo; cleaves either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptideor a bond within the cross-linking peptide (e.g. stapholysin), with preference for Gly bonds; used by certain bacteria to lyse cell walls of other bacteria, either as a defensive or feeding mechanism Endopeptidases that lyse bacterial cell wall peptidoglycans Organic Nitrogen Peptidase 0 0 -M27 Catlytic type: Metallo; cleaves synaptobrevin 2 at the Gln76-Phe77 bond or at the Gln60-Lys61 bond; synaptobrevin is the only known substrate of this class Highly selective metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M38 Catlytic type: Metallo; releases an N-terminal isoaspartate from select dipeptides, with beta-Asp|+|Leu being the best cleavage site An omega peptidase Organic Nitrogen Peptidase 0 0 -M41 Catlytic type: Metallo; degrades a given membrane bound substrate molecule progressively from either N-terminus or C-terminus ; a member is FtsH peptidase (Escherichia coli) ATP-dependent metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M42 Catlytic type: Metallo; broad specificity Metalloaminopeptidases some of which also have acylaminoacylpeptidase activity Organic Nitrogen Peptidase 0 0 -M43B Catlytic type: Metallo; cleave insulin-like growth factor binding-protein 5 (IGFBP-5) at Ser143-Lys144 or cleave IGFBP-1 at Met135-Lys136 Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M43A Catlytic type: Metallo; cleaves beta-casein at Pro63-Gly64 and Met102-Ala103 Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M44 Catlytic type: Metallo; processes the viral polyprotein into multiple fragments at Ala-GlyXaa motifs where Xaa is Ala, Ser, Thr or Lys; essential for virus maturation Metalloendopeptidase from the pox viruses Organic Nitrogen Peptidase 0 0 -M48C Catlytic type: Metallo; requirement for substrates that are prenylated at a C-terminal motif known as CAAX, in which A is an aliphatic residue, and the lipid is attached to the cysteine residue; Eukaryotic Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M48B Catlytic type: Metallo; requirement for substrates that are prenylated at a C-terminal motif known as CAAX, in which A is an aliphatic residue, and the lipid is attached to the cysteine residue; Eukaryotic Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M48A Catlytic type: Metallo; requirement for substrates that are prenylated at a C-terminal motif known as CAAX, in which A is an aliphatic residue, and the lipid is attached to the cysteine residue; Eukaryotic Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M56 Catlytic type: Metallo; Autolysis of the BlaR1 precursor occurs at Arg293-Arg; allow bacteria to respond to the presence of beta-lactam antibiotics by the expression of beta-lactamases and penicillin-binding proteins Membrane-bound bacterial endopeptidases Organic Nitrogen Peptidase 0 0 -M60 Catlytic type: Metallo; degrades into a number of fragments with site specificity unknown; only currently identified substrate for enhancin is insect intestinal mucin Metalloendopeptidases Organic Nitrogen Peptidase 0 0 -M67C Catlytic type: Metallo; cleaves Lys48-linked tetra-ubiquitin and Lys63-linked polyubiquitin chains Isopeptidases that release ubiquitin from ubiquitinated proteins Organic Nitrogen Peptidase 0 0 -M67B Catlytic type: Metallo; cleaves Lys48-linked tetra-ubiquitin and Lys63-linked polyubiquitin chains Isopeptidases that release ubiquitin from ubiquitinated proteins Organic Nitrogen Peptidase 0 0 -M67A Catlytic type: Metallo; cleaves Lys48-linked tetra-ubiquitin and Lys63-linked polyubiquitin chains Isopeptidases that release ubiquitin from ubiquitinated proteins Organic Nitrogen Peptidase 0 0 -M78 Catlytic type: Metallo; Cleaves of ImmR occurs at Phe95+Met, releasing the N-terminal DNA-binding domain Metallo-endopeptidases Organic Nitrogen Peptidase 0 0 -M79 Catlytic type: Metallo; cleaves at the -Cys(R)Xaa-Xaa-Xbb, in which Cys(R) is cysteine in which the thiol is substituted with a C15(farnesyl) or C20 (geranylgeranyl) side chain, Xaa is normally a small, aliphatic residue, and Xbb is any amino acid Specialised endopeptidases that typically cleave a C-terminal tripeptide from an isoprenylated protein Organic Nitrogen Peptidase 0 0 -M86 Catlytic type: Metallo; hydrolyse gamma-linked poly-DL-glutamic acid (gamma-DL-PGA), giving final products no smaller than trimers, even when subjected to prolonged incubation or the addition of more enzyme; phage encoded peptidase gamma-PGA Poly-gamma-glutamyl hydrolases Organic Nitrogen Peptidase 0 0 -N01 Catlytic type: Asparagine; autolytic cleavage of Asn363-Ala364 releasing a 44-residue C-terminal fragment; peptidases in family N1 are the coat proteins from nodaviruses, single-stranded RNA viruses; coat protein precursor undergoes slow, autolytic maturation in which cleavage of the coat protein helps stabilize the virion and is an important stage in maturation of the virus An endopeptidase Organic Nitrogen Peptidase 0 0 -N02 Catlytic type: Asparagine; autolytic cleavage of Asn570-Phe571 releasing a 74-residue fragment from the C-terminus of the coat protein only the endopeptidase of tetraviruses Organic Nitrogen Peptidase 0 0 -N04 Catlytic type: Asparagine; release of the passenger domain from the precursor; cleavage causes the virulence factor to be secreted (shown in E. coli) Tsh-associated self-cleaving domain Organic Nitrogen Peptidase 0 0 -N05 Catlytic type: Asparagine; release of an N-terminal 44-residue peptide from the N-terminus of the coat protein; important for virion stabilization Self-cleaving endopeptidases Organic Nitrogen Peptidase 0 0 -N07 Catlytic type: Asparagine; cleaves one of the capsid proteins at at Asn42; important for virion stabilization Self-cleaving endopeptidases Organic Nitrogen Peptidase 0 0 -N08 Catlytic type: Asparagine; cleaves the VP0 viral capsid protein into VP2 and VP4 in the provirion Self-cleaving endopeptidases Organic Nitrogen Peptidase 0 0 -N09 Catlytic type: Asparagine; release of the intein from the extein; intein is a polypeptide insert into another protein (the extein) which is able to release itself from the host protein and splice the two portions of the extein together Self-cleaving proteins Organic Nitrogen Peptidase 0 0 -N10E Catlytic type: Asparagine; first residue of the intein must by Cys, Ser or Thr and the last residue of the intein must be Asn or Gln; the first residue of the second portion of the extein must be Cys, Ser or Thr.; An intein is a polypeptide insert into another protein (the extein) which is able to release itself from the host protein and splice the two portions of the extein together. self-cleaving proteins Organic Nitrogen Peptidase 0 0 -N10D Catlytic type: Asparagine; first residue of the intein must by Cys, Ser or Thr and the last residue of the intein must be Asn or Gln; the first residue of the second portion of the extein must be Cys, Ser or Thr.; An intein is a polypeptide insert into another protein (the extein) which is able to release itself from the host protein and splice the two portions of the extein together. self-cleaving proteins Organic Nitrogen Peptidase 0 0 -N10C Catlytic type: Asparagine; first residue of the intein must by Cys, Ser or Thr and the last residue of the intein must be Asn or Gln; the first residue of the second portion of the extein must be Cys, Ser or Thr.; An intein is a polypeptide insert into another protein (the extein) which is able to release itself from the host protein and splice the two portions of the extein together. self-cleaving proteins Organic Nitrogen Peptidase 0 0 -N10B Catlytic type: Asparagine; first residue of the intein must by Cys, Ser or Thr and the last residue of the intein must be Asn or Gln; the first residue of the second portion of the extein must be Cys, Ser or Thr.; An intein is a polypeptide insert into another protein (the extein) which is able to release itself from the host protein and splice the two portions of the extein together. self-cleaving proteins Organic Nitrogen Peptidase 0 0 -N11 Catlytic type: Asparagine; cleaves at the start and end of the intein, which is then released Self-cleaving proteins Organic Nitrogen Peptidase 0 0 -S01F Catlytic type: Serine; 3 types:trypsin-like where there is cleavage of amide substrates following Arg or Lys at P1, chymotrypsin-like where cleavage occurs following one of the hydrophobic amino acids at P1, and elastase-like with cleavage following an Ala at P1 Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S01E Catlytic type: Serine; 3 types:trypsin-like where there is cleavage of amide substrates following Arg or Lys at P1, chymotrypsin-like where cleavage occurs following one of the hydrophobic amino acids at P1, and elastase-like with cleavage following an Ala at P1 Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S01D Catlytic type: Serine; 3 types:trypsin-like where there is cleavage of amide substrates following Arg or Lys at P1, chymotrypsin-like where cleavage occurs following one of the hydrophobic amino acids at P1, and elastase-like with cleavage following an Ala at P1 Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S01C Catlytic type: Serine; 3 types:trypsin-like where there is cleavage of amide substrates following Arg or Lys at P1, chymotrypsin-like where cleavage occurs following one of the hydrophobic amino acids at P1, and elastase-like with cleavage following an Ala at P1 Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S01B Catlytic type: Serine; 3 types:trypsin-like where there is cleavage of amide substrates following Arg or Lys at P1, chymotrypsin-like where cleavage occurs following one of the hydrophobic amino acids at P1, and elastase-like with cleavage following an Ala at P1 Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S01A Catlytic type: Serine; 3 types:trypsin-like where there is cleavage of amide substrates following Arg or Lys at P1, chymotrypsin-like where cleavage occurs following one of the hydrophobic amino acids at P1, and elastase-like with cleavage following an Ala at P1 Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S03 Catlytic type: Serine; cis cleavage of the Trp264-Ser bond at its own C-terminus to release it from the polyprotein; RNA virus protein excised from the polyprotein that forms the viral coat Viral endopeptidase togavirin Organic Nitrogen Peptidase 0 0 -S06 Catlytic type: Serine; cleave human IgA1 in a part of the hinge region that is absent from IgA2 Serine endopeptidases of bacteria Organic Nitrogen Peptidase 0 0 -S07 Catlytic type: Serine; cleaves at sites like -Xaa-XaaYaa-, where Xaa is normally an amino acid with a basic side chain, and Yaa has a short side chain Serine endopeptidase Organic Nitrogen Peptidase 0 0 -S08C Catlytic type: Serine; nonspecific peptidases with a preference to cleave after hydrophobic residues; secreted or attached to the cell wall Serine endopeptidase subtilisin and its homologues Organic Nitrogen Peptidase 0 0 -S08B Catlytic type: Serine; nonspecific peptidases with a preference to cleave after hydrophobic residues; secreted or attached to the cell wall Serine endopeptidase subtilisin and its homologues Organic Nitrogen Peptidase 0 0 -S08A Catlytic type: Serine; nonspecific peptidases with a preference to cleave after hydrophobic residues; secreted or attached to the cell wall Serine endopeptidase subtilisin and its homologues Organic Nitrogen Peptidase 0 0 -S09D Catlytic type: Serine; generally cleaves prolyl bonds, with some exceptions (see additional information); oligopeptidase B cleaves Arg and Lys bonds; acylaminoacyl-peptidase releases an N-acylated amino acid from an oligopeptide blocked by a acetyl, chloroacetyl, formyl or carbamyl group Serine-dependent peptidases Organic Nitrogen Peptidase 0 0 -S09C Catlytic type: Serine; generally cleaves prolyl bonds, with some exceptions (see additional information); oligopeptidase B cleaves Arg and Lys bonds; acylaminoacyl-peptidase releases an N-acylated amino acid from an oligopeptide blocked by a acetyl, chloroacetyl, formyl or carbamyl group Serine-dependent peptidases Organic Nitrogen Peptidase 0 0 -S09B Catlytic type: Serine; generally cleaves prolyl bonds, with some exceptions (see additional information); oligopeptidase B cleaves Arg and Lys bonds; acylaminoacyl-peptidase releases an N-acylated amino acid from an oligopeptide blocked by a acetyl, chloroacetyl, formyl or carbamyl group Serine-dependent peptidases Organic Nitrogen Peptidase 0 0 -S09A Catlytic type: Serine; generally cleaves prolyl bonds, with some exceptions (see additional information); oligopeptidase B cleaves Arg and Lys bonds; acylaminoacyl-peptidase releases an N-acylated amino acid from an oligopeptide blocked by a acetyl, chloroacetyl, formyl or carbamyl group Serine-dependent peptidases Organic Nitrogen Peptidase 0 0 -S11 Catlytic type: Serine; transfer of the C-terminal D-Ala to water OR the peptidoglycan monomer is transferred to an exogenous receptor after removal of the C-terminal D-Ala (some have both activities); mainly involved in the synthesis of bacterial cell walls Serine-type D-Ala-D-Ala carboxypeptidases Organic Nitrogen Peptidase 0 0 -S12 Catlytic type: Serine; wide range of activities and specificities; involved in the synthesis and remodelling of bacterial cell walls Serine-type D-Ala-D-Ala carboxypeptidases Organic Nitrogen Peptidase 0 0 -S14 Catlytic type: Serine; cleaves preferentially after nonpolar residues; involved in quality control and the regulatory degradation of specific proteins Endopeptidase Clp and its homologues Organic Nitrogen Peptidase 0 0 -S16 Catlytic type: Serine; cleaves when P1 is Leu; ATP-dependent peptidase and a protein-activated ATPase Endopeptidases, mostly ATP-dependent Organic Nitrogen Peptidase 0 0 -S21 Catlytic type: Serine; cleaves at Val/Leu-Xaa-AlaSer, where Xaa is a polar residue; involved in the late stages of assembly of the viral prohead, breaking down the scaffold protein upon which the prohead is assembled Assemblins, which are processing endopeptidases of the herpesviruses, one of the groups of DNA viruses Organic Nitrogen Peptidase 0 0 -S24 Catlytic type: Serine; cleaves.at an Ala-Gly or a Cys-Gly bond Two-domain proteins that undergo autolysis, separating the functional domains Organic Nitrogen Peptidase 0 0 -S26C Catlytic type: Serine; removes hydrophobic, N-terminal signal peptides as the proteins are translocated across membranes; 'Ala-Xaa-Ala' motif preceding the cleavage site; major enzymes that remove the signal peptides and facilitate secretion Peptidase family S26 contains endopeptidases Organic Nitrogen Peptidase 0 0 -S26B Catlytic type: Serine; removes hydrophobic, N-terminal signal peptides as the proteins are translocated across membranes; 'Ala-Xaa-Ala' motif preceding the cleavage site; major enzymes that remove the signal peptides and facilitate secretion Peptidase family S26 contains endopeptidases Organic Nitrogen Peptidase 0 0 -S26A Catlytic type: Serine; removes hydrophobic, N-terminal signal peptides as the proteins are translocated across membranes; 'Ala-Xaa-Ala' motif preceding the cleavage site; major enzymes that remove the signal peptides and facilitate secretion Peptidase family S26 contains endopeptidases Organic Nitrogen Peptidase 0 0 -S28 Catlytic type: Serine; cleaves the -Pro-Xaa bond, in which Xaa is C-terminal Exopeptidases that hydrolyse prolyl bonds, and are known only from eukaryotes Organic Nitrogen Peptidase 0 0 -S29 Catlytic type: Serine; cleaves when P1 residue at each site is Cys or Thr; member is hepacivirin Polyprotein-processing peptidases of hepatitis viruses Organic Nitrogen Peptidase 0 0 -S30 Catlytic type: Serine; cleaves a bond at its own C-terminus where the the scissile bond is -Xaa-Ser-, in which Xaa is Phe or Tyr; essential for viral infectivity Viral polyprotein-processing peptidases Organic Nitrogen Peptidase 0 0 -S31 Catlytic type: Serine; cleaves each pestivirus polyprotein at four positions, between NS3 and NS4, NS4A and NS4B, NS4B and NS5A, and between NS5A and NS5B; essential for viral replication Polyprotein processing endopeptidase from pestiviruses Organic Nitrogen Peptidase 0 0 -S32 Catlytic type: Serine; cleaves at four Glu-Gly bonds and one Glu-Ser bond in the ORF1a polyprotein, and an additional two Glu-Gly and one Gln-Ser bond in the ORF1b polyprotein; Arteriviruses are RNA viruses with a genome that encodes two polyproteins, ORF1a and ORF1ab. One of the arterivirus polyprotein processing endopeptidases Organic Nitrogen Peptidase 0 0 -S33 Catlytic type: Serine; releases an N-terminal residue from a peptide, preferably (but not exclusively) a proline; secreted or periplasmic enzymes;Prolyl aminopeptidase may confer a selective advantage allowing a bacterium to utilize proline-rich substrates Exopeptidases that act at the N-terminus of peptides Organic Nitrogen Peptidase 0 0 -S49C Catlytic type: Serine; hydrolyzes the N-blocked p-nitrophenyl esters of Gly, Ala, Phe, Val, Leu and Trp; prefers hydrophobic amino acids on either side of the scissile bond and will not cleave a peptide containing fewer than six amino acids; destruction of cleaved signal pepides in the periplasmic space Endopeptidases Organic Nitrogen Peptidase 0 0 -S49B Catlytic type: Serine; hydrolyzes the N-blocked p-nitrophenyl esters of Gly, Ala, Phe, Val, Leu and Trp; prefers hydrophobic amino acids on either side of the scissile bond and will not cleave a peptide containing fewer than six amino acids; destruction of cleaved signal pepides in the periplasmic space Endopeptidases Organic Nitrogen Peptidase 0 0 -S49A Catlytic type: Serine; hydrolyzes the N-blocked p-nitrophenyl esters of Gly, Ala, Phe, Val, Leu and Trp; prefers hydrophobic amino acids on either side of the scissile bond and will not cleave a peptide containing fewer than six amino acids; destruction of cleaved signal pepides in the periplasmic space Endopeptidases Organic Nitrogen Peptidase 0 0 -S50 Catlytic type: Serine; cleaves the polyprotein at two sites both containing Ala; processes the viral polyprotein and releases itself and the major capsid proteins Polyprotein processing endopeptidases from double-stranded RNA viruses Organic Nitrogen Peptidase 0 0 -S53 Catlytic type: Serine; preferences for hydrophobic residues in the P1 and P2 positions; secreted proteins Acid-acting endopeptidases and a tripeptidyl-peptidase Organic Nitrogen Peptidase 0 0 -S54 Catlytic type: Serine; membrane bound Membrane-bound serine endopeptidases Organic Nitrogen Peptidase 0 0 -S62 Catlytic type: Serine; cleaves the chymotrypsin substrate Suc-Leu-Leu-Val-Tyr-NHMec and casein ; not essential but when absent, reduces viral growth Viral endopeptidases Organic Nitrogen Peptidase 0 0 -S65 Catlytic type: Serine; processes of the polyprotein occurs at Phe-Xaa-Xaa-Gln+ consensus sequences Endopeptidases Organic Nitrogen Peptidase 0 0 -S69 Catlytic type: Serine; cleaves alanyl bonds in the processing of a viral polyprotein Viral endopeptidases Organic Nitrogen Peptidase 0 0 -S73 Catlytic type: Serine Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S74 Catlytic type: Serine; autoproteolysis releases the chaperone domains Serine endopeptidases Organic Nitrogen Peptidase 0 0 -S75 Catlytic type: Serine; cleaves several sites in the polyprotein, with cleavage at Gln(Ala/Thr) ; processes the relicase polyprotein 1ab releasing individual proteins Endopeptidases Organic Nitrogen Peptidase 0 0 -S77 Catlytic type: Serine; cleaves P22, IPII, IPIII and P68 at selected GluAla bonds; cleaves P23 at a GluGly bond; processing of prohead protein Prohead endopeptidase from bacteriophage T4 Organic Nitrogen Peptidase 0 0 -S78 Catlytic type: Serine; processes the coat protein at the lysyl bond; involved in the maturation of the phage prohead Endopeptidases from bacteriophages Organic Nitrogen Peptidase 0 0 -S80 Catlytic type: Serine; cleaves at Ser/Ala/Gly)-Xaa-Glu+; perform all the processing cleavages required for maturation of the viral prohead prohead peptidase gp175 Organic Nitrogen Peptidase 0 0 -S81 Catlytic type: Serine; cleaves the beta-(1,4)-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine of the peptidoglycan of bacterial cell walls Isopeptidases Organic Nitrogen Peptidase 0 0 -T01B Catlytic type: Threonine; eukaryotic proteasome has three different activities (trypsin-like, chymotrypsin-like and cleavage after glutamate); archaean and bacterial proteasomes have only chymotrypsin-like activity; involved in turnover of intracellular proteins Component peptidases of the proteasome and related compound peptidases Organic Nitrogen Peptidase 0 0 -T01A Catlytic type: Threonine; eukaryotic proteasome has three different activities (trypsin-like, chymotrypsin-like and cleavage after glutamate); archaean and bacterial proteasomes have only chymotrypsin-like activity; involved in turnover of intracellular proteins Component peptidases of the proteasome and related compound peptidases Organic Nitrogen Peptidase 0 0 -T03 Catlytic type: Threonine; catalyzes the transfer of the gamma-glutamyl moiety of gamma-glutamyl-derived peptides such as glutathione (gammaGlu-Cys-Gly), and anilides such as gamma-glutamyl-7-amido-4-methylcoumarin (gammaGlu-AMC) to acceptor molecules including water and various dipeptides Self-processing proteins that express aminopeptidase as well as aminotransferase activities in their mature forms Organic Nitrogen Peptidase 0 0 -U32 degrades soluble and reconstituted fibrillar type I collagen Endopeptidases from bacteria Organic Nitrogen Peptidase 0 0 -U40 cleaves the cell wall peptide bridge formed by meso-2,6-diaminopimelic acid and D-Ala; component of the bacteriophage lysin Protein P5 murein endopeptidase from bacteriophage phi-6 Organic Nitrogen Peptidase 0 0 -K06073 ABC.VB12.P, btuC; vitamin B12 transport system permease protein Cobalamin salvage Transporters Vitamin B12 transport system 0 0 -K06074 ABC.VB12.A, btuD; vitamin B12 transport system ATP-binding protein [EC:3.6.3.33] Cobalamin salvage Transporters Vitamin B12 transport system 0 0 -K06858 ABC.VB12.S1, btuF; vitamin B12 transport system substrate-binding protein Cobalamin salvage Transporters Vitamin B12 transport system 0 0 -K16092 btuB; vitamin B12 transporter Cobalamin salvage Transporters Vitamin B12 transport system 0 0 -K02048 cysP; sulfate/thiosulfate transport system substrate-binding protein Sulfate/thiosulfate transport system Transporters 0 0 -K23163 sbp; sulfate/thiosulfate transport system substrate-binding protein Sulfate/thiosulfate transport system Transporters 0 0 -K02046 cysU; sulfate/thiosulfate transport system permease protein Sulfate/thiosulfate transport system Transporters 0 0 -K02047 cysW; sulfate/thiosulfate transport system permease protein Sulfate/thiosulfate transport system Transporters 0 0 -K02045 cysA; sulfate/thiosulfate transport system ATP-binding protein [EC:7.3.2.3] Sulfate/thiosulfate transport system Transporters 0 0 -K10013 ABC.ARG.S; lysine/arginine/ornithine transport system substrate-binding protein Lysine/arginine/ornithine transport system Transporters 0 0 -K10015 hisM; histidine transport system permease protein Lysine/arginine/ornithine transport system Transporters 0 0 -K10016 hisQ; histidine transport system permease protein Lysine/arginine/ornithine transport system Transporters 0 0 -K10017 hisP; histidine transport system ATP-binding protein [EC:7.4.2.1] Lysine/arginine/ornithine transport system Transporters 0 0 -K10014 hisJ; histidine transport system substrate-binding protein Histidine transport system Transporters 0 0 -K10015 hisM; histidine transport system permease protein Histidine transport system Transporters 0 0 -K10016 hisQ; histidine transport system permease protein Histidine transport system Transporters 0 0 -K10017 hisP; histidine transport system ATP-binding protein [EC:7.4.2.1] Histidine transport system Transporters 0 0 -K10036 glnH; glutamine transport system substrate-binding protein Glutamine transport system Transporters 0 0 -K10037 glnP; glutamine transport system permease protein Glutamine transport system Transporters 0 0 -K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1] Glutamine transport system Transporters 0 0 -K10039 peb1A, glnH; aspartate/glutamate/glutamine transport system substrate-binding protein Aspartate/glutamate/glutamine transport system Transporters 0 0 -K10040 peb1B, glnP, glnM; aspartate/glutamate/glutamine transport system permease protein Aspartate/glutamate/glutamine transport system Transporters 0 0 -K10041 peb1C, glnQ; aspartate/glutamate/glutamine transport system ATP-binding protein [EC:7.4.2.1] Aspartate/glutamate/glutamine transport system Transporters 0 0 -K09996 artJ; arginine transport system substrate-binding protein Arginine transport system Transporters 0 0 -K09997 artI; arginine transport system substrate-binding protein Arginine transport system Transporters 0 0 -K09998 artM; arginine transport system permease protein Arginine transport system Transporters 0 0 -K09999 artQ; arginine transport system permease protein Arginine transport system Transporters 0 0 -K10000 artP; arginine transport system ATP-binding protein [EC:7.4.2.1] Arginine transport system Transporters 0 0 -K10001 gltI; glutamate/aspartate transport system substrate-binding protein Glutamate/aspartate transport system Transporters 0 0 -K10002 gltK; glutamate/aspartate transport system permease protein Glutamate/aspartate transport system Transporters 0 0 -K10003 gltJ; glutamate/aspartate transport system permease protein Glutamate/aspartate transport system Transporters 0 0 -K10004 gltL; glutamate/aspartate transport system ATP-binding protein [EC:7.4.2.1] Glutamate/aspartate transport system Transporters 0 0 -K10018 occT; octopine/nopaline transport system substrate-binding protein Octopine/nopaline transport system Transporters 0 0 -K10019 occM; octopine/nopaline transport system permease protein Octopine/nopaline transport system Transporters 0 0 -K10020 occQ; octopine/nopaline transport system permease protein Octopine/nopaline transport system Transporters 0 0 -K10021 occP; octopine/nopaline transport system ATP-binding protein [EC:7.4.2.1] Octopine/nopaline transport system Transporters 0 0 -K09969 aapJ; general L-amino acid transport system substrate-binding protein General L-amino acid transport system Transporters 0 0 -K09970 aapQ; general L-amino acid transport system permease protein General L-amino acid transport system Transporters 0 0 -K09971 aapM; general L-amino acid transport system permease protein General L-amino acid transport system Transporters 0 0 -K09972 aapP; general L-amino acid transport system ATP-binding protein [EC:3.6.3.-] General L-amino acid transport system Transporters 0 0 -K10005 gluB; glutamate transport system substrate-binding protein Glutamate transport system Transporters 0 0 -K10006 gluC; glutamate transport system permease protein Glutamate transport system Transporters 0 0 -K10007 gluD; glutamate transport system permease protein Glutamate transport system Transporters 0 0 -K10008 gluA; glutamate transport system ATP-binding protein [EC:7.4.2.1] Glutamate transport system Transporters 0 0 -K02424 fliY, tcyA; L-cystine transport system substrate-binding protein L-Cystine transport system Transporters 0 0 -K10009 tcyB, yecS; L-cystine transport system permease protein L-Cystine transport system Transporters 0 0 -K10010 tcyC, yecC; L-cystine transport system ATP-binding protein [EC:7.4.2.1] L-Cystine transport system Transporters 0 0 -K10022 aotJ; arginine/ornithine transport system substrate-binding protein Arginine/ornithine transport system Transporters 0 0 -K10023 aotM; arginine/ornithine transport system permease protein Arginine/ornithine transport system Transporters 0 0 -K10024 aotQ; arginine/ornithine transport system permease protein Arginine/ornithine transport system Transporters 0 0 -K10025 aotP; arginine/ornithine transport system ATP-binding protein [EC:7.4.2.1] Arginine/ornithine transport system Transporters 0 0 -K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein Putative polar amino acid transport system Transporters 0 0 -K02029 ABC.PA.P; polar amino acid transport system permease protein Putative polar amino acid transport system Transporters 0 0 -K02028 ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:7.4.2.1] Putative polar amino acid transport system Transporters 0 0 -K01999 livK; branched-chain amino acid transport system substrate-binding protein Branched-chain amino acid transport system Transporters 0 0 -K01997 livH; branched-chain amino acid transport system permease protein Branched-chain amino acid transport system Transporters 0 0 -K01998 livM; branched-chain amino acid transport system permease protein Branched-chain amino acid transport system Transporters 0 0 -K01995 livG; branched-chain amino acid transport system ATP-binding protein Branched-chain amino acid transport system Transporters 0 0 -K01996 livF; branched-chain amino acid transport system ATP-binding protein Branched-chain amino acid transport system Transporters 0 0 -K02073 ABC.MET.S; D-methionine transport system substrate-binding protein D-Methionine transport system Transporters 0 0 -K02072 ABC.MET.P; D-methionine transport system permease protein D-Methionine transport system Transporters 0 0 -K02071 ABC.MET.A; D-methionine transport system ATP-binding protein D-Methionine transport system Transporters 0 0 -K02048 cysP; sulfate/thiosulfate transport system substrate-binding protein Sulfate/thiosulfate transport system Transporters 0 0 -K23163 sbp; sulfate/thiosulfate transport system substrate-binding protein Sulfate/thiosulfate transport system Transporters 0 0 -K02046 cysU; sulfate/thiosulfate transport system permease protein Sulfate/thiosulfate transport system Transporters 0 0 -K02047 cysW; sulfate/thiosulfate transport system permease protein Sulfate/thiosulfate transport system Transporters 0 0 -K02045 cysA; sulfate/thiosulfate transport system ATP-binding protein [EC:7.3.2.3] Sulfate/thiosulfate transport system Transporters 0 0 -K05772 tupA; tungstate transport system substrate-binding protein Tungstate transport system Transporters 0 0 -K05773 tupB; tungstate transport system permease protein Tungstate transport system Transporters 0 0 -K06857 tupC; tungstate transport system ATP-binding protein Tungstate transport system Transporters 0 0 -K02051 ABC.SN.S; sulfonate/nitrate/taurine transport system substrate-binding protein NitT/TauT family transport system Transporters 0 0 -K02050 ABC.SN.P; sulfonate/nitrate/taurine transport system permease protein NitT/TauT family transport system Transporters 0 0 -K02049 ABC.SN.A; sulfonate/nitrate/taurine transport system ATP-binding protein NitT/TauT family transport system Transporters 0 0 -K02020 modA; molybdate transport system substrate-binding protein Molybdate transport system Transporters 0 0 -K02018 modB; molybdate transport system permease protein Molybdate transport system Transporters 0 0 -K02017 modC; molybdate transport system ATP-binding protein [EC:3.6.3.29] Molybdate transport system Transporters 0 0 -K05776 modF; molybdate transport system ATP-binding protein Molybdate transport system Transporters 0 0 -K02012 ABC.FE.S; iron(III) transport system substrate-binding protein Iron(III) transport system Transporters 0 0 -K02011 ABC.FE.P; iron(III) transport system permease protein Iron(III) transport system Transporters 0 0 -K02010 ABC.FE.A; iron(III) transport system ATP-binding protein [EC:3.6.3.30] Iron(III) transport system Transporters 0 0 -K02064 ABC.VB1.S; thiamine transport system substrate-binding protein Thiamine transport system Transporters 0 0 -K02063 ABC.VB1.P; thiamine transport system permease protein Thiamine transport system Transporters 0 0 -K02062 ABC.VB1.A; thiamine transport system ATP-binding protein Thiamine transport system Transporters 0 0 -K05777 ABC.VB1X.S; putative thiamine transport system substrate-binding protein Putative thiamine transport system Transporters 0 0 -K05778 ABC.VB1X.P; putative thiamine transport system permease protein Putative thiamine transport system Transporters 0 0 -K05779 ABC.VB1X.A; putative thiamine transport system ATP-binding protein Putative thiamine transport system Transporters 0 0 -K02055 ABC.SP.S; putative spermidine/putrescine transport system substrate-binding protein Putative spermidine/putrescine transport system Transporters 0 0 -K02053 ABC.SP.P; putative spermidine/putrescine transport system permease protein Putative spermidine/putrescine transport system Transporters 0 0 -K02054 ABC.SP.P1; putative spermidine/putrescine transport system permease protein Putative spermidine/putrescine transport system Transporters 0 0 -K02052 ABC.SP.A; putative spermidine/putrescine transport system ATP-binding protein Putative spermidine/putrescine transport system Transporters 0 0 -K10108 malE; maltose/maltodextrin transport system substrate-binding protein Maltose/maltodextrin transport system Transporters 0 0 -K10109 malF; maltose/maltodextrin transport system permease protein Maltose/maltodextrin transport system Transporters 0 0 -K10110 malG; maltose/maltodextrin transport system permease protein Maltose/maltodextrin transport system Transporters 0 0 -K10111 malK; maltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19] Maltose/maltodextrin transport system Transporters 0 0 -K10112 msmX; maltose/maltodextrin transport system ATP-binding protein Maltose/maltodextrin transport system Transporters 0 0 -K10117 msmE; raffinose/stachyose/melibiose transport system substrate-binding protein Raffinose/stachyose/melibiose transport system Transporters 0 0 -K10118 msmF; raffinose/stachyose/melibiose transport system permease protein Raffinose/stachyose/melibiose transport system Transporters 0 0 -K10119 msmG; raffinose/stachyose/melibiose transport system permease protein Raffinose/stachyose/melibiose transport system Transporters 0 0 -K10112 msmX; multiple sugar transport system ATP-binding protein Raffinose/stachyose/melibiose transport system Transporters 0 0 -K10120 K10120; fructooligosaccharide transport system substrate-binding protein Putative fructooligosaccharide transport system Transporters 0 0 -K10121 K10121; fructooligosaccharide transport system permease protein Putative fructooligosaccharide transport system Transporters 0 0 -K10122 K10122; fructooligosaccharide transport system permease protein Putative fructooligosaccharide transport system Transporters 0 0 -K10112 msmX; multiple sugar transport system ATP-binding protein Putative fructooligosaccharide transport system Transporters 0 0 -K05813 ugpB; sn-glycerol 3-phosphate transport system substrate-binding protein Putative sn-glycerol-phosphate transport system Transporters 0 0 -K05814 ugpA; sn-glycerol 3-phosphate transport system permease protein Putative sn-glycerol-phosphate transport system Transporters 0 0 -K05815 ugpE; sn-glycerol 3-phosphate transport system permease protein Putative sn-glycerol-phosphate transport system Transporters 0 0 -K05816 ugpC; sn-glycerol 3-phosphate transport system ATP-binding protein [EC:3.6.3.20] Putative sn-glycerol-phosphate transport system Transporters 0 0 -K10188 lacE; lactose/L-arabinose transport system substrate-binding protein L-Arabinose/lactose transport system Transporters 0 0 -K10189 lacF; lactose/L-arabinose transport system permease protein L-Arabinose/lactose transport system Transporters 0 0 -K10190 lacG; lactose/L-arabinose transport system permease protein L-Arabinose/lactose transport system Transporters 0 0 -K10191 lacK; lactose/L-arabinose transport system ATP-binding protein L-Arabinose/lactose transport system Transporters 0 0 -K10227 smoE; sorbitol/mannitol transport system substrate-binding protein Putative sorbitol/mannitol transport system Transporters 0 0 -K10228 smoF; sorbitol/mannitol transport system permease protein Putative sorbitol/mannitol transport system Transporters 0 0 -K10229 smoG; sorbitol/mannitol transport system permease protein Putative sorbitol/mannitol transport system Transporters 0 0 -K10111 malK; multiple sugar transport system ATP-binding protein [EC:3.6.3.-] Putative sorbitol/mannitol transport system Transporters 0 0 -K10112 msmX; multiple sugar transport system ATP-binding protein Putative sorbitol/mannitol transport system Transporters 0 0 -K10232 aglE; alpha-glucoside transport system substrate-binding protein alpha-Glucoside transport system Transporters 0 0 -K10233 aglF; alpha-glucoside transport system permease protein alpha-Glucoside transport system Transporters 0 0 -K10234 aglG; alpha-glucoside transport system permease protein alpha-Glucoside transport system Transporters 0 0 -K10235 aglK; alpha-glucoside transport system ATP-binding protein alpha-Glucoside transport system Transporters 0 0 -K10112 msmX; multiple sugar transport system ATP-binding protein alpha-Glucoside transport system Transporters 0 0 -K10192 togB; oligogalacturonide transport system substrate-binding protein Oligogalacturonide transport system Transporters 0 0 -K10193 togM; oligogalacturonide transport system permease protein Oligogalacturonide transport system Transporters 0 0 -K10194 togN; oligogalacturonide transport system permease protein Oligogalacturonide transport system Transporters 0 0 -K10195 togA; oligogalacturonide transport system ATP-binding protein Oligogalacturonide transport system Transporters 0 0 -K10196 ABC.GLC.S; glucose/arabinose transport system substrate-binding protein Glucose/arabinose transport system Transporters 0 0 -K10197 ABC.GLC.P; glucose/arabinose transport system permease protein Glucose/arabinose transport system Transporters 0 0 -K10198 ABC.GLC.P1; glucose/arabinose transport system permease protein Glucose/arabinose transport system Transporters 0 0 -K10199 ABC.GLC.A; glucose/arabinose transport system ATP-binding protein Glucose/arabinose transport system Transporters 0 0 -K10236 thuE; trehalose/maltose transport system substrate-binding protein Trehalose/maltose transport system Transporters 0 0 -K10237 thuF; trehalose/maltose transport system permease protein Trehalose/maltose transport system Transporters 0 0 -K10238 thuG; trehalose/maltose transport system permease protein Trehalose/maltose transport system Transporters 0 0 -K10111 malK; multiple sugar transport system ATP-binding protein [EC:3.6.3.-] Trehalose/maltose transport system Transporters 0 0 -K10200 ABC.NGC.S; N-acetylglucosamine transport system substrate-binding protein N-Acetylglucosamine transport system Transporters 0 0 -K10201 ABC.NGC.P; N-acetylglucosamine transport system permease protein N-Acetylglucosamine transport system Transporters 0 0 -K10202 ABC.NGC.P1; N-acetylglucosamine transport system permease protein N-Acetylglucosamine transport system Transporters 0 0 -K10240 cebE; cellobiose transport system substrate-binding protein Cellobiose transport system Transporters 0 0 -K10241 cebF; cellobiose transport system permease protein Cellobiose transport system Transporters 0 0 -K10242 cebG; cellobiose transport system permease protein Cellobiose transport system Transporters 0 0 -K10112 msmX; multiple sugar transport system ATP-binding protein Cellobiose transport system Transporters 0 0 -K02027 ABC.MS.S; multiple sugar transport system substrate-binding protein Putative multiple sugar transport system Transporters 0 0 -K02025 ABC.MS.P; multiple sugar transport system permease protein Putative multiple sugar transport system Transporters 0 0 -K02026 ABC.MS.P1; multiple sugar transport system permease protein Putative multiple sugar transport system Transporters 0 0 -K10111 malK; multiple sugar transport system ATP-binding protein [EC:3.6.3.-] Putative multiple sugar transport system Transporters 0 0 -K10112 msmX; multiple sugar transport system ATP-binding protein Putative multiple sugar transport system Transporters 0 0 -K02002 proX; glycine betaine/proline transport system substrate-binding protein Glycine betaine/proline transport system Transporters 0 0 -K02001 proW; glycine betaine/proline transport system permease protein Glycine betaine/proline transport system Transporters 0 0 -K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:3.6.3.32] Glycine betaine/proline transport system Transporters 0 0 -K05845 ABC.BCP1.S; osmoprotectant transport system substrate-binding protein Osmoprotectant transport system Transporters 0 0 -K05846 ABC.BCP1.P; osmoprotectant transport system permease protein Osmoprotectant transport system Transporters 0 0 -K05847 ABC.BCP1.A; osmoprotectant transport system ATP-binding protein Osmoprotectant transport system Transporters 0 0 -K07323 mlaC; phospholipid transport system substrate-binding protein Phospholipid transport system Transporters 0 0 -K02067 mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein Phospholipid transport system Transporters 0 0 -K02066 mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein Phospholipid transport system Transporters 0 0 -K02065 mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein Phospholipid transport system Transporters 0 0 -K07122 mlaB; phospholipid transport system transporter-binding protein Phospholipid transport system Transporters 0 0 -K02069 ABC.X2.P; putative ABC transport system permease protein Putative ABC transport system Transporters 0 0 -K02068 ABC.X2.A; putative ABC transport system ATP-binding protein Putative ABC transport system Transporters 0 0 -K10439 rbsB; ribose transport system substrate-binding protein Ribose transport system Transporters 0 0 -K10440 rbsC; ribose transport system permease protein Ribose transport system Transporters 0 0 -K10441 rbsA; ribose transport system ATP-binding protein [EC:3.6.3.17] Ribose transport system Transporters 0 0 -K10537 araF; L-arabinose transport system substrate-binding protein L-Arabinose transport system Transporters 0 0 -K10538 araH; L-arabinose transport system permease protein L-Arabinose transport system Transporters 0 0 -K10539 araG; L-arabinose transport system ATP-binding protein [EC:3.6.3.17] L-Arabinose transport system Transporters 0 0 -K10540 mglB; methyl-galactoside transport system substrate-binding protein Methyl-galactoside transport system Transporters 0 0 -K10541 mglC; methyl-galactoside transport system permease protein Methyl-galactoside transport system Transporters 0 0 -K10542 mglA; methyl-galactoside transport system ATP-binding protein [EC:3.6.3.17] Methyl-galactoside transport system Transporters 0 0 -K10543 xylF; D-xylose transport system substrate-binding protein D-Xylose transport system Transporters 0 0 -K10544 xylH; D-xylose transport system permease protein D-Xylose transport system Transporters 0 0 -K10545 xylG; D-xylose transport system ATP-binding protein [EC:3.6.3.17] D-Xylose transport system Transporters 0 0 -K10546 ABC.GGU.S; putative multiple sugar transport system substrate-binding protein Multiple sugar transport system Transporters 0 0 -K10547 ABC.GGU.P; putative multiple sugar transport system permease protein Multiple sugar transport system Transporters 0 0 -K10548 ABC.GGU.A; putative multiple sugar transport system ATP-binding protein Multiple sugar transport system Transporters 0 0 -K10549 alsB; D-allose transport system substrate-binding protein D-Allose transport system Transporters 0 0 -K10550 alsC; D-allose transport system permease protein D-Allose transport system Transporters 0 0 -K10551 alsA; D-allose transport system ATP-binding protein [EC:3.6.3.17] D-Allose transport system Transporters 0 0 -K10552 frcB; fructose transport system substrate-binding protein Fructose transport system Transporters 0 0 -K10553 frcC; fructose transport system permease protein Fructose transport system Transporters 0 0 -K10554 frcA; fructose transport system ATP-binding protein Fructose transport system Transporters 0 0 -K10555 lsrB; AI-2 transport system substrate-binding protein AI-2 transport system Transporters 0 0 -K10556 lsrC; AI-2 transport system permease protein AI-2 transport system Transporters 0 0 -K10557 lsrD; AI-2 transport system permease protein AI-2 transport system Transporters 0 0 -K10558 lsrA; AI-2 transport system ATP-binding protein AI-2 transport system Transporters 0 0 -K10559 rhaS1; rhamnose transport system substrate-binding protein Rhamnose transport system Transporters 0 0 -K10560 rhaP; rhamnose transport system permease protein Rhamnose transport system Transporters 0 0 -K10561 rhaQ; rhamnose transport system permease protein Rhamnose transport system Transporters 0 0 -K10562 rhaT; rhamnose transport system ATP-binding protein [EC:3.6.3.17] Rhamnose transport system Transporters 0 0 -K02058 ABC.SS.S; simple sugar transport system substrate-binding protein Putative simple sugar transport system Transporters 0 0 -K02057 ABC.SS.P; simple sugar transport system permease protein Putative simple sugar transport system Transporters 0 0 -K02056 ABC.SS.A; simple sugar transport system ATP-binding protein [EC:3.6.3.17] Putative simple sugar transport system Transporters 0 0 -K02040 pstS; phosphate transport system substrate-binding protein Phosphate transport system Transporters 0 0 -K02037 pstC; phosphate transport system permease protein Phosphate transport system Transporters 0 0 -K02038 pstA; phosphate transport system permease protein Phosphate transport system Transporters 0 0 -K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] Phosphate transport system Transporters 0 0 -K02044 phnD; phosphonate transport system substrate-binding protein Phosphonate transport system Transporters 0 0 -K02042 phnE; phosphonate transport system permease protein Phosphonate transport system Transporters 0 0 -K02041 phnC; phosphonate transport system ATP-binding protein [EC:7.3.2.2] Phosphonate transport system Transporters 0 0 -K16905 K16905; fluoroquinolone transport system permease protein Fluoroquinolone transport system Transporters 0 0 -K16906 K16906; fluoroquinolone transport system permease protein Fluoroquinolone transport system Transporters 0 0 -K16907 K16907; fluoroquinolone transport system ATP-binding protein [EC:3.6.3.-] Fluoroquinolone transport system Transporters 0 0 -K10013 ABC.ARG.S; lysine/arginine/ornithine transport system substrate-binding protein Lysine/arginine/ornithine transport system Transporters 0 0 -K10015 hisM; histidine transport system permease protein Lysine/arginine/ornithine transport system Transporters 0 0 -K10016 hisQ; histidine transport system permease protein Lysine/arginine/ornithine transport system Transporters 0 0 -K10017 hisP; histidine transport system ATP-binding protein [EC:7.4.2.1] Lysine/arginine/ornithine transport system Transporters 0 0 -K10014 hisJ; histidine transport system substrate-binding protein Histidine transport system Transporters 0 0 -K10015 hisM; histidine transport system permease protein Histidine transport system Transporters 0 0 -K10016 hisQ; histidine transport system permease protein Histidine transport system Transporters 0 0 -K10017 hisP; histidine transport system ATP-binding protein [EC:7.4.2.1] Histidine transport system Transporters 0 0 -K10036 glnH; glutamine transport system substrate-binding protein Glutamine transport system Transporters 0 0 -K10037 glnP; glutamine transport system permease protein Glutamine transport system Transporters 0 0 -K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1] Glutamine transport system Transporters 0 0 -K10039 peb1A, glnH; aspartate/glutamate/glutamine transport system substrate-binding protein Aspartate/glutamate/glutamine transport system Transporters 0 0 -K10040 peb1B, glnP, glnM; aspartate/glutamate/glutamine transport system permease protein Aspartate/glutamate/glutamine transport system Transporters 0 0 -K10041 peb1C, glnQ; aspartate/glutamate/glutamine transport system ATP-binding protein [EC:7.4.2.1] Aspartate/glutamate/glutamine transport system Transporters 0 0 -K09996 artJ; arginine transport system substrate-binding protein Arginine transport system Transporters 0 0 -K09997 artI; arginine transport system substrate-binding protein Arginine transport system Transporters 0 0 -K09998 artM; arginine transport system permease protein Arginine transport system Transporters 0 0 -K09999 artQ; arginine transport system permease protein Arginine transport system Transporters 0 0 -K10000 artP; arginine transport system ATP-binding protein [EC:7.4.2.1] Arginine transport system Transporters 0 0 -K10001 gltI; glutamate/aspartate transport system substrate-binding protein Glutamate/aspartate transport system Transporters 0 0 -K10002 gltK; glutamate/aspartate transport system permease protein Glutamate/aspartate transport system Transporters 0 0 -K10003 gltJ; glutamate/aspartate transport system permease protein Glutamate/aspartate transport system Transporters 0 0 -K10004 gltL; glutamate/aspartate transport system ATP-binding protein [EC:7.4.2.1] Glutamate/aspartate transport system Transporters 0 0 -K10018 occT; octopine/nopaline transport system substrate-binding protein Octopine/nopaline transport system Transporters 0 0 -K10019 occM; octopine/nopaline transport system permease protein Octopine/nopaline transport system Transporters 0 0 -K10020 occQ; octopine/nopaline transport system permease protein Octopine/nopaline transport system Transporters 0 0 -K10021 occP; octopine/nopaline transport system ATP-binding protein [EC:7.4.2.1] Octopine/nopaline transport system Transporters 0 0 -K09969 aapJ; general L-amino acid transport system substrate-binding protein General L-amino acid transport system Transporters 0 0 -K09970 aapQ; general L-amino acid transport system permease protein General L-amino acid transport system Transporters 0 0 -K09971 aapM; general L-amino acid transport system permease protein General L-amino acid transport system Transporters 0 0 -K09972 aapP; general L-amino acid transport system ATP-binding protein [EC:3.6.3.-] General L-amino acid transport system Transporters 0 0 -K10005 gluB; glutamate transport system substrate-binding protein Glutamate transport system Transporters 0 0 -K10006 gluC; glutamate transport system permease protein Glutamate transport system Transporters 0 0 -K10007 gluD; glutamate transport system permease protein Glutamate transport system Transporters 0 0 -K10008 gluA; glutamate transport system ATP-binding protein [EC:7.4.2.1] Glutamate transport system Transporters 0 0 -K02424 fliY, tcyA; L-cystine transport system substrate-binding protein L-Cystine transport system Transporters 0 0 -K10009 tcyB, yecS; L-cystine transport system permease protein L-Cystine transport system Transporters 0 0 -K10010 tcyC, yecC; L-cystine transport system ATP-binding protein [EC:7.4.2.1] L-Cystine transport system Transporters 0 0 -K10022 aotJ; arginine/ornithine transport system substrate-binding protein Arginine/ornithine transport system Transporters 0 0 -K10023 aotM; arginine/ornithine transport system permease protein Arginine/ornithine transport system Transporters 0 0 -K10024 aotQ; arginine/ornithine transport system permease protein Arginine/ornithine transport system Transporters 0 0 -K10025 aotP; arginine/ornithine transport system ATP-binding protein [EC:7.4.2.1] Arginine/ornithine transport system Transporters 0 0 -K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein Putative polar amino acid transport system Transporters 0 0 -K02029 ABC.PA.P; polar amino acid transport system permease protein Putative polar amino acid transport system Transporters 0 0 -K02028 ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:7.4.2.1] Putative polar amino acid transport system Transporters 0 0 -K01999 livK; branched-chain amino acid transport system substrate-binding protein Branched-chain amino acid transport system Transporters 0 0 -K01997 livH; branched-chain amino acid transport system permease protein Branched-chain amino acid transport system Transporters 0 0 -K01998 livM; branched-chain amino acid transport system permease protein Branched-chain amino acid transport system Transporters 0 0 -K01995 livG; branched-chain amino acid transport system ATP-binding protein Branched-chain amino acid transport system Transporters 0 0 -K01996 livF; branched-chain amino acid transport system ATP-binding protein Branched-chain amino acid transport system Transporters 0 0 -K02073 ABC.MET.S; D-methionine transport system substrate-binding protein D-Methionine transport system Transporters 0 0 -K02072 ABC.MET.P; D-methionine transport system permease protein D-Methionine transport system Transporters 0 0 -K02071 ABC.MET.A; D-methionine transport system ATP-binding protein D-Methionine transport system Transporters 0 0 -K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein Peptides/nickel transport system Transporters 0 0 -K02033 ABC.PE.P; peptide/nickel transport system permease protein Peptides/nickel transport system Transporters 0 0 -K02034 ABC.PE.P1; peptide/nickel transport system permease protein Peptides/nickel transport system Transporters 0 0 -K02031 ABC.PE.A; peptide/nickel transport system ATP-binding protein Peptides/nickel transport system Transporters 0 0 -K02032 ABC.PE.A1; peptide/nickel transport system ATP-binding protein Peptides/nickel transport system Transporters 0 0 -K02016 ABC.FEV.S; iron complex transport system substrate-binding protein Iron complex transport system Transporters 0 0 -K02015 ABC.FEV.P; iron complex transport system permease protein Iron complex transport system Transporters 0 0 -K02013 ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34] Iron complex transport system Transporters 0 0 -K06858 ABC.VB12.S1; vitamin B12 transport system substrate-binding protein Vitamin B12 transport system Transporters 0 0 -K06073 ABC.VB12.P; vitamin B12 transport system permease protein Vitamin B12 transport system Transporters 0 0 -K06074 ABC.VB12.A; vitamin B12 transport system ATP-binding protein [EC:3.6.3.33] Vitamin B12 transport system Transporters 0 0 -K09815 znuA; zinc transport system substrate-binding protein Zinc transport system Transporters 0 0 -K09816 znuB; zinc transport system permease protein Zinc transport system Transporters 0 0 -K09817 znuC; zinc transport system ATP-binding protein [EC:3.6.3.-] Zinc transport system Transporters 0 0 -K09818 ABC.MN.S; manganese/iron transport system substrate-binding protein Manganese/iron transport system Transporters 0 0 -K09819 ABC.MN.P; manganese/iron transport system permease protein Manganese/iron transport system Transporters 0 0 -K09820 ABC.MN.A; manganese/iron transport system ATP-binding protein Manganese/iron transport system Transporters 0 0 -K02077 ABC.ZM.S; zinc/manganese transport system substrate-binding protein Putative zinc/manganese transport system Transporters 0 0 -K02075 ABC.ZM.P; zinc/manganese transport system permease protein Putative zinc/manganese transport system Transporters 0 0 -K02074 ABC.ZM.A; zinc/manganese transport system ATP-binding protein Putative zinc/manganese transport system Transporters 0 0 -K02009 cbiN; cobalt transport protein Cobalt/nickel transport system Transporters 0 0 -K02008 cbiQ; cobalt/nickel transport system permease protein Cobalt/nickel transport system Transporters 0 0 -K02007 cbiM; cobalt/nickel transport system permease protein Cobalt/nickel transport system Transporters 0 0 -K02006 cbiO; cobalt/nickel transport system ATP-binding protein Cobalt/nickel transport system Transporters 0 0 -K16915 cbiL; nickel transport protein Nickel transport system Transporters 0 0 -K02009 cbiN; cobalt transport protein Nickel transport system Transporters 0 0 -K10094 cbiK; nickel transport system substrate-binding protein Nickel transport system Transporters 0 0 -K02008 cbiQ; cobalt/nickel transport system permease protein Nickel transport system Transporters 0 0 -K02007 cbiM; cobalt/nickel transport system permease protein Nickel transport system Transporters 0 0 -K02006 cbiO; cobalt/nickel transport system ATP-binding protein Nickel transport system Transporters 0 0 -K01989 ABC.X4.S; putative ABC transport system substrate-binding protein Putative ABC transport system Transporters 0 0 -K05832 ABC.X4.P; putative ABC transport system permease protein Putative ABC transport system Transporters 0 0 -K05833 ABC.X4.A; putative ABC transport system ATP-binding protein Putative ABC transport system Transporters 0 0 -K09688 ABC-2.CPSE.P; capsular polysaccharide transport system permease protein Capsular polysaccharide transport system Transporters 0 0 -K10107 ABC-2.CPSE.P1; capsular polysaccharide transport system permease protein Capsular polysaccharide transport system Transporters 0 0 -K09689 ABC-2.CPSE.A; capsular polysaccharide transport system ATP-binding protein Capsular polysaccharide transport system Transporters 0 0 -K09690 ABC-2.LPSE.P; lipopolysaccharide transport system permease protein Lipopolysaccharide transport system Transporters 0 0 -K09691 ABC-2.LPSE.A; lipopolysaccharide transport system ATP-binding protein Lipopolysaccharide transport system Transporters 0 0 -K09692 tagG; teichoic acid transport system permease protein Teichoic acid transport system Transporters 0 0 -K09693 tagH; teichoic acid transport system ATP-binding protein [EC:3.6.3.40] Teichoic acid transport system Transporters 0 0 -K09694 nodJ; lipooligosaccharide transport system permease protein Lipooligosaccharide transport system Transporters 0 0 -K09695 nodI; lipooligosaccharide transport system ATP-binding protein Lipooligosaccharide transport system Transporters 0 0 -K09696 natB; sodium transport system permease protein Sodium transport system Transporters 0 0 -K09697 natA; sodium transport system ATP-binding protein Sodium transport system Transporters 0 0 -K01992 ABC-2.P; ABC-2 type transport system permease protein ABC-2 type transport system Transporters 0 1 -K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein ABC-2 type transport system Transporters 0 1 -K09808 ABC.LPT.P; lipoprotein-releasing system permease protein Lipoprotein-releasing system Transporters 0 0 -K09810 ABC.LPT.A; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-] Lipoprotein-releasing system Transporters 0 0 -K09811 ftsX; cell division transport system permease protein Cell division transport system Transporters 0 0 -K09812 ftsE; cell division transport system ATP-binding protein Cell division transport system Transporters 0 0 -K09813 hrtB; hemin transport system permease protein Hemin transport system Transporters 0 0 -K09814 hrtA; hemin transport system ATP-binding protein [EC:3.6.3.-] Hemin transport system Transporters 0 0 -K02004 ABC.CD.P; Putative ABC transport system Transporters 0 0 -K02003 ABC.CD.A; Putative ABC transport system Transporters 0 0 -K02195 ccmC; heme exporter membrane protein CcmC Heme transport system Transporters 0 0 -K02194 ccmB; heme exporter membrane protein CcmB Heme transport system Transporters 0 0 -K02193 ccmA; heme exporter ATP-binding protein CcmA [EC:3.6.3.41] Heme transport system Transporters 0 0 -K02777 PTS-Glc-EIIA; PTS system, glucose-specific IIA component PTS system, glucose-specific II component Transporters 0 0 -K02778 PTS-Glc-EIIB; PTS system, glucose-specific IIB component PTS system, glucose-specific II component Transporters 0 0 -K02779 PTS-Glc-EIIC; PTS system, glucose-specific IIC component PTS system, glucose-specific II component Transporters 0 0 -K02777 PTS-Glc-EIIA; PTS system, sugar-specific IIA component PTS system, maltose/glucose-specific II component Transporters 0 0 -K02790 PTS-MalGlc-EIIB; PTS system, maltose/glucose-specific IIB component PTS system, maltose/glucose-specific II component Transporters 0 0 -K02791 PTS-MalGlc-EIIC; PTS system, maltose/glucose-specific IIC component PTS system, maltose/glucose-specific II component Transporters 0 0 -K02802 PTS-Nag-EIIA; PTS system, N-acetylglucosamine-specific IIA component PTS system, N-acetylglucosamine-specific II component Transporters 0 0 -K02803 PTS-Nag-EIIB; PTS system, N-acetylglucosamine-specific IIB component PTS system, N-acetylglucosamine-specific II component Transporters 0 0 -K02804 PTS-Nag-EIIC; PTS system, N-acetylglucosamine-specific IIC component PTS system, N-acetylglucosamine-specific II component Transporters 0 0 -K02777 PTS-Glc-EIIA; PTS system, sugar-specific IIA component PTS system, alpha-glucoside-specific II component Transporters 0 0 -K02749 PTS-Glv-EIIB; PTS system, alpha-glucoside-specific IIB component PTS system, alpha-glucoside-specific II component Transporters 0 0 -K02750 PTS-Glv-EIIC; PTS system, alpha-glucoside-specific IIC component PTS system, alpha-glucoside-specific II component Transporters 0 0 -K02808 PTS-Scr-EIIA; PTS system, sucrose-specific IIA component PTS system, sucrose-specific II component Transporters 0 0 -K02809 PTS-Scr-EIIB; PTS system, sucrose-specific IIB component PTS system, sucrose-specific II component Transporters 0 0 -K02810 PTS-Scr-EIIC; PTS system, sucrose-specific IIC component PTS system, sucrose-specific II component Transporters 0 0 -K02777 PTS-Glc-EIIA; PTS system, glucose-specific IIA component PTS system, trehalose-specific II component Transporters 0 0 -K02817 PTS-Tre-EIIA; PTS system, trehalose-specific IIA component PTS system, trehalose-specific II component Transporters 0 0 -K02818 PTS-Tre-EIIB; PTS system, trehalose-specific IIB component PTS system, trehalose-specific II component Transporters 0 0 -K02819 PTS-Tre-EIIC; PTS system, trehalose-specific IIC component PTS system, trehalose-specific II component Transporters 0 0 -K02755 PTS-Bgl-EIIA; PTS system, beta-glucoside-specific IIA component PTS system, beta-glucoside-specific II component Transporters 0 0 -K02756 PTS-Bgl-EIIB; PTS system, beta-glucoside-specific IIB component PTS system, beta-glucoside-specific II component Transporters 0 0 -K02757 PTS-Bgl-EIIC; PTS system, beta-glucoside-specific IIC component PTS system, beta-glucoside-specific II component Transporters 0 0 -K02777 PTS-Glc-EIIA; PTS system, sugar-specific IIA component PTS system, beta-glucoside (arbutin/salicin/cellobiose)-specific II component Transporters 0 0 -K02752 PTS-Asc-EIIB; PTS system, beta-glucoside (arbutin/salicin/cellobiose)-specific IIB component PTS system, beta-glucoside (arbutin/salicin/cellobiose)-specific II component Transporters 0 0 -K02753 PTS-Asc-EIIC; PTS system, beta-glucoside (arbutin/salicin/cellobiose)-specific IIC component PTS system, beta-glucoside (arbutin/salicin/cellobiose)-specific II component Transporters 0 0 -K02768 PTS-Fru-EIIA; PTS system, fructose-specific IIA component PTS system, fructose-specific II component Transporters 0 0 -K02769 PTS-Fru-EIIB; PTS system, fructose-specific IIB component PTS system, fructose-specific II component Transporters 0 0 -K02770 PTS-Fru-EIIC; PTS system, fructose-specific IIC component PTS system, fructose-specific II component Transporters 0 0 -K02798 PTS-Mtl-EIIA; PTS system, mannitol-specific IIA component PTS system, mannitol-specific II component Transporters 0 0 -K02799 PTS-Mtl-EIIB; PTS system, mannitol-specific IIB component PTS system, mannitol-specific II component Transporters 0 0 -K02800 PTS-Mtl-EIIC; PTS system, mannitol-specific IIC component PTS system, mannitol-specific II component Transporters 0 0 -K02759 PTS-Cel-EIIA; PTS system, cellobiose-specific IIA component PTS system, cellobiose-specific II component Transporters 0 0 -K02760 PTS-Cel-EIIB; PTS system, cellobiose-specific IIB component PTS system, cellobiose-specific II component Transporters 0 0 -K02761 PTS-Cel-EIIC; PTS system, cellobiose-specific IIC component PTS system, cellobiose-specific II component Transporters 0 0 -K02793 PTS-Man-EIIA; PTS system, mannose-specific IIA component PTS system, mannose-specific II component Transporters 0 0 -K02794 PTS-Man-EIIB; PTS system, mannose-specific IIB component PTS system, mannose-specific II component Transporters 0 0 -K02795 PTS-Man-EIIC; PTS system, mannose-specific IIC component PTS system, mannose-specific II component Transporters 0 0 -K02796 PTS-Man-EIID; PTS system, mannose-specific IID component PTS system, mannose-specific II component Transporters 0 0 -K02744 PTS-Aga-EIIA; PTS system, N-acetylgalactosamine-specific IIA component PTS system, N-acetylgalactosamine-specific II component Transporters 0 0 -K02745 PTS-Aga-EIIB; PTS system, N-acetylgalactosamine-specific IIB component PTS system, N-acetylgalactosamine-specific II component Transporters 0 0 -K02746 PTS-Aga-EIIC; PTS system, N-acetylgalactosamine-specific IIC component PTS system, N-acetylgalactosamine-specific II component Transporters 0 0 -K02747 PTS-Aga-EIID; PTS system, N-acetylgalactosamine-specific IID component PTS system, N-acetylgalactosamine-specific II component Transporters 0 0 -K02812 PTS-Sor-EIIA; PTS system, sorbose-specific IIA component PTS system, sorbose-specific II component Transporters 0 0 -K02813 PTS-Sor-EIIB; PTS system, sorbose-specific IIB component PTS system, sorbose-specific II component Transporters 0 0 -K02814 PTS-Sor-EIIC; PTS system, sorbose-specific IIC component PTS system, sorbose-specific II component Transporters 0 0 -K02815 PTS-Sor-EIID; PTS system, sorbose-specific IID component PTS system, sorbose-specific II component Transporters 0 0 -K02773 PTS-Gat-EIIA; PTS system, galactitol-specific IIA component PTS system, galactitol-specific II component Transporters 0 0 -K02774 PTS-Gat-EIIB; PTS system, galactitol-specific IIB component PTS system, galactitol-specific II component Transporters 0 0 -K02775 PTS-Gat-EIIC; PTS system, galactitol-specific IIC component PTS system, galactitol-specific II component Transporters 0 0 -K02781 PTS-Gut-EIIA; PTS system, glucitol/sorbitol-specific IIA component PTS system, glucitol/sorbitol-specific II component Transporters 0 0 -K02782 PTS-Gut-EIIB; PTS system, glucitol/sorbitol-specific IIB component PTS system, glucitol/sorbitol-specific II component Transporters 0 0 -K02783 PTS-Gut-EIIC; PTS system, glucitol/sorbitol-specific IIC component PTS system, glucitol/sorbitol-specific II component Transporters 0 0 -K02786 PTS-Lac-EIIA; PTS system, lactose-specific IIA component PTS system, lactose-specific II component Transporters 0 0 -K02787 PTS-Lac-EIIB; PTS system, lactose-specific IIB component PTS system, lactose-specific II component Transporters 0 0 -K02788 PTS-Lac-EIIC; PTS system, lactose-specific IIC component PTS system, lactose-specific II component Transporters 0 0 -K02763 PTS-Dgl-EIIA; PTS system, D-glucosamine-specific IIA component PTS system, D-glucosamine-specific II component Transporters 0 0 -K02764 PTS-Dgl-EIIB; PTS system, D-glucosamine-specific IIB component PTS system, D-glucosamine-specific II component Transporters 0 0 -K02765 PTS-Dgl-EIIC; PTS system, D-glucosamine-specific IIC component PTS system, D-glucosamine-specific II component Transporters 0 0 -K02821 PTS-Ula-EIIA; PTS system, ascorbate-specific IIA component PTS system, ascorbate-specific II component Transporters 0 0 -K02822 PTS-Ula-EIIB; PTS system, ascorbate-specific IIB component PTS system, ascorbate-specific II component Transporters 0 0 -K03475 PTS-Ula-EIIC; PTS system, ascorbate-specific IIC component PTS system, ascorbate-specific II component Transporters 0 0 -K11051 ABC-2.CYL.P; multidrug/hemolysin transport system permease protein Multidrug/hemolysin transport system Transporters 0 0 -K11050 ABC-2.CYL.A; multidrug/hemolysin transport system ATP-binding protein Multidrug/hemolysin transport system Transporters 0 0 -K11069 potD; spermidine/putrescine transport system substrate-binding protein Spermidine/putrescine transport system Transporters 0 0 -K11070 potC; spermidine/putrescine transport system permease protein Spermidine/putrescine transport system Transporters 0 0 -K11071 potB; spermidine/putrescine transport system permease protein Spermidine/putrescine transport system Transporters 0 0 -K11072 potA; spermidine/putrescine transport system ATP-binding protein Spermidine/putrescine transport system Transporters 0 0 -K11073 potF; putrescine transport system substrate-binding protein Putrescine transport system Transporters 0 0 -K11074 potI; putrescine transport system permease protein Putrescine transport system Transporters 0 0 -K11075 potH; putrescine transport system permease protein Putrescine transport system Transporters 0 0 -K11076 potG; putrescine transport system ATP-binding protein Putrescine transport system Transporters 0 0 -K11077 attC; mannopine transport system substrate-binding protein Mannopine transport system Transporters 0 0 -K11078 attB; mannopine transport system permease protein Mannopine transport system Transporters 0 0 -K11079 attA2; mannopine transport system permease protein Mannopine transport system Transporters 0 0 -K11080 attA1; mannopine transport system ATP-binding protein Mannopine transport system Transporters 0 0 -K11081 phnS; 2-aminoethylphosphonate transport system substrate-binding protein 2-Aminoethylphosphonate transport system Transporters 0 0 -K11082 phnV; 2-aminoethylphosphonate transport system permease protein 2-Aminoethylphosphonate transport system Transporters 0 0 -K11083 phnU; 2-aminoethylphosphonate transport system permease protein 2-Aminoethylphosphonate transport system Transporters 0 0 -K11084 phnT; 2-aminoethylphosphonate transport system ATP-binding protein 2-Aminoethylphosphonate transport system Transporters 0 0 -K02777 PTS-Glc-EIIA; PTS system, glucose-specific IIA component PTS system, N-acetylmuramic acid-specific II component Transporters 0 0 -K11191 PTS-Mur-EIIB; PTS system, N-acetylmuramic acid-specific IIB component PTS system, N-acetylmuramic acid-specific II component Transporters 0 0 -K11192 PTS-Mur-EIIC; PTS system, N-acetylmuramic acid-specific IIC component PTS system, N-acetylmuramic acid-specific II component Transporters 0 0 -K11194 PTS-Fru1-EIIA; PTS system, fructose-specific IIA component PTS system, fructose-specific II component Transporters 0 0 -K11195 PTS-Fru1-EIIB; PTS system, fructose-specific IIB component PTS system, fructose-specific II component Transporters 0 0 -K11196 PTS-Fru1-EIIC; PTS system, fructose-specific IIC component PTS system, fructose-specific II component Transporters 0 0 -K02771 PTS-Fru1-EIID; PTS system, fructose-specific IID component PTS system, fructose-specific II component Transporters 0 0 -K11198 PTS-Mng-EIIA; PTS system, 2-O-A-mannosyl-D-glycerate-specific IIA component PTS system, 2-O-A-mannosyl-D-glycerate-specific II component Transporters 0 0 -K11199 PTS-Mng-EIIB; PTS system, 2-O-A-mannosyl-D-glycerate-specific IIB component PTS system, 2-O-A-mannosyl-D-glycerate-specific II component Transporters 0 0 -K11200 PTS-Mng-EIIC; PTS system, 2-O-A-mannosyl-D-glycerate-specific IIC component PTS system, 2-O-A-mannosyl-D-glycerate-specific II component Transporters 0 0 -K11201 PTS-Fru2-EIIA; PTS system, fructose-specific IIA-like component PTS system, fructose-specific II-like component Transporters 0 0 -K11202 PTS-Fru2-EIIB; PTS system, fructose-specific IIB-like component PTS system, fructose-specific II-like component Transporters 0 0 -K11203 PTS-Fru2-EIIC; PTS system, fructose-specific IIC-like component PTS system, fructose-specific II-like component Transporters 0 0 -K11632 bceB; bacitracin transport system permease protein Bacitracin transport system Transporters 0 0 -K11631 bceA; bacitracin transport system ATP-binding protein Bacitracin transport system Transporters 0 0 -K11636 yxdM; putative ABC transport system permease protein Uncharacterized ABC transport system Transporters 0 0 -K11635 yxdL; putative ABC transport system ATP-binding protein Uncharacterized ABC transport system Transporters 0 0 -K11601 mntC; manganese transport system substrate-binding protein Manganese transport system Transporters 0 0 -K11602 mntB; manganese transport system permease protein Manganese transport system Transporters 0 0 -K11603 mntA; manganese transport system ATP-binding protein Manganese transport system Transporters 0 0 -K11604 sitA; manganese/iron transport system substrate-binding protein Manganese/iron transport system Transporters 0 0 -K11605 sitC; manganese/iron transport system permease protein Manganese/iron transport system Transporters 0 0 -K11606 sitD; manganese/iron transport system permease protein Manganese/iron transport system Transporters 0 0 -K11607 sitB; manganese/iron transport system ATP-binding protein Manganese/iron transport system Transporters 0 0 -K11704 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein Iron/zinc/manganese/copper transport system Transporters 0 0 -K11705 mtsC; iron/zinc/manganese/copper transport system permease protein Iron/zinc/manganese/copper transport system Transporters 0 0 -K11706 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein Iron/zinc/manganese/copper transport system Transporters 0 0 -K11707 troA; manganese/zinc/iron transport system substrate-binding protein Manganese/zinc/iron transport system Transporters 0 0 -K11708 troC; manganese/zinc/iron transport system permease protein Manganese/zinc/iron transport system Transporters 0 0 -K11709 troD; manganese/zinc/iron transport system permease protein Manganese/zinc/iron transport system Transporters 0 0 -K11710 troB; manganese/zinc/iron transport system ATP-binding protein Manganese/zinc/iron transport system Transporters 0 0 -K07091 lptF; lipopolysaccharide export system permease protein Lipopolysaccharide export system Transporters 0 0 -K11720 lptG; lipopolysaccharide export system permease protein Lipopolysaccharide export system Transporters 0 0 -K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-] Lipopolysaccharide export system Transporters 0 0 -K11950 cmpA; bicarbonate transport system substrate-binding protein Bicarbonate transport system Transporters 0 0 -K11951 cmpB; bicarbonate transport system permease protein Bicarbonate transport system Transporters 0 0 -K11952 cmpC; bicarbonate transport system ATP-binding protein [EC:3.6.3.-] Bicarbonate transport system Transporters 0 0 -K11953 cmpD; bicarbonate transport system ATP-binding protein [EC:3.6.3.-] Bicarbonate transport system Transporters 0 0 -K11954 K11954; neutral amino acid transport system substrate-binding protein Neutral amino acid transport system Transporters 0 0 -K11955 natC; neutral amino acid transport system permease protein Neutral amino acid transport system Transporters 0 0 -K11956 natD; neutral amino acid transport system permease protein Neutral amino acid transport system Transporters 0 0 -K11957 K11957; neutral amino acid transport system ATP-binding protein Neutral amino acid transport system Transporters 0 0 -K11958 natE; neutral amino acid transport system ATP-binding protein Neutral amino acid transport system Transporters 0 0 -K11959 urtA; urea transport system substrate-binding protein Urea transport system Transporters 0 0 -K11960 urtB; urea transport system permease protein Urea transport system Transporters 0 0 -K11961 urtC; urea transport system permease protein Urea transport system Transporters 0 0 -K11962 urtD; urea transport system ATP-binding protein Urea transport system Transporters 0 0 -K11963 urtE; urea transport system ATP-binding protein Urea transport system Transporters 0 0 -K12368 dppA; dipeptide transport system substrate-binding protein Dipeptide transport system Transporters 0 0 -K12369 dppB; dipeptide transport system permease protein Dipeptide transport system Transporters 0 0 -K12370 dppC; dipeptide transport system permease protein Dipeptide transport system Transporters 0 0 -K12371 dppD; dipeptide transport system ATP-binding protein Dipeptide transport system Transporters 0 0 -K12372 dppF; dipeptide transport system ATP-binding protein Dipeptide transport system Transporters 0 0 -K11004 hlyB; ATP-binding cassette, subfamily B, bacterial HlyB/CyaB alpha-Hemolysin/cyclolysin transport system Transporters 0 0 -K11003 hlyD; hemolysin D alpha-Hemolysin/cyclolysin transport system Transporters 0 0 -K12340 tolC; outer membrane channel protein TolC alpha-Hemolysin/cyclolysin transport system Transporters 0 0 -K12530 rtxB; ATP-binding cassette, subfamily B, bacterial RtxB RTX toxin transport system Transporters 0 0 -K12531 rtxE; ATP-binding cassette, subfamily B, bacterial RtxE RTX toxin transport system Transporters 0 0 -K12532 rtxD; RTX toxin transporter RTX toxin transport system Transporters 0 0 -K12340 tolC; outer membrane channel protein TolC RTX toxin transport system Transporters 0 0 -K12533 rsaD; ATP-binding cassette, subfamily C, bacterial RsaD S-Layer protein transport system Transporters 0 0 -K12534 rsaE; membrane fusion protein RsaE S-Layer protein transport system Transporters 0 0 -K12535 rsaF; outer membrane protein RsaF S-Layer protein transport system Transporters 0 0 -K12536 hasD; ATP-binding cassette, subfamily C, bacterial HasD Hemophore/metalloprotease transport system Transporters 0 0 -K12537 hasE; protease secretion protein HasE Hemophore/metalloprotease transport system Transporters 0 0 -K12538 hasF; outer membrane protein HasF Hemophore/metalloprotease transport system Transporters 0 0 -K12539 prsD; ATP-binding cassette, subfamily C, bacterial PrsD Multiple protein transport system Transporters 0 0 -K12540 prsE; membrane fusion protein PrsE Multiple protein transport system Transporters 0 0 -K12541 lapB; ATP-binding cassette, subfamily C, bacterial LapB Adhesin protein transport system Transporters 0 0 -K12542 lapC; membrane fusion protein LapC Adhesin protein transport system Transporters 0 0 -K12543 lapE; outer membrane protein LapE Adhesin protein transport system Transporters 0 0 -K13889 gsiB; glutathione transport system substrate-binding protein Glutathione transport system Transporters 0 0 -K13890 gsiC; glutathione transport system permease protein Glutathione transport system Transporters 0 0 -K13891 gsiD; glutathione transport system permease protein Glutathione transport system Transporters 0 0 -K13892 gsiA; glutathione transport system ATP-binding protein Glutathione transport system Transporters 0 0 -K13893 yejA; microcin C transport system substrate-binding protein Microcin C transport system Transporters 0 0 -K13894 yejB; microcin C transport system permease protein Microcin C transport system Transporters 0 0 -K13895 yejE; microcin C transport system permease protein Microcin C transport system Transporters 0 0 -K13896 yejF; microcin C transport system ATP-binding protein Microcin C transport system Transporters 0 0 -K15551 tauA; taurine transport system substrate-binding protein Taurine transport system Transporters 0 0 -K15552 tauC; taurine transport system permease protein Taurine transport system Transporters 0 0 -K10831 tauB; taurine transport system ATP-binding protein [EC:3.6.3.36] Taurine transport system Transporters 0 0 -K15553 ssuA; sulfonate transport system substrate-binding protein Sulfonate transport system Transporters 0 0 -K15554 ssuC; sulfonate transport system permease protein Sulfonate transport system Transporters 0 0 -K15555 ssuB; sulfonate transport system ATP-binding protein [EC:3.6.3.-] Sulfonate transport system Transporters 0 0 -K15556 ophF; phthalate transport system substrate-binding protein Phthalate transport system Transporters 0 0 -K15557 ophG; phthalate transport system permease protein Phthalate transport system Transporters 0 0 -K15558 ophH; phthalate transport system ATP-binding protein Phthalate transport system Transporters 0 0 -K15580 oppA; oligopeptide transport system substrate-binding protein Oligopeptide transport system Transporters 0 0 -K15581 oppB; oligopeptide transport system permease protein Oligopeptide transport system Transporters 0 0 -K15582 oppC; oligopeptide transport system permease protein Oligopeptide transport system Transporters 0 0 -K15583 oppD; oligopeptide transport system ATP-binding protein Oligopeptide transport system Transporters 0 0 -K10823 oppF; oligopeptide transport system ATP-binding protein Oligopeptide transport system Transporters 0 0 -K15584 nikA; nickel transport system substrate-binding protein Nickel transport system Transporters 0 0 -K15585 nikB; nickel transport system permease protein Nickel transport system Transporters 0 0 -K15586 nikC; nickel transport system permease protein Nickel transport system Transporters 0 0 -K15587 nikD; nickel transport system ATP-binding protein [EC:3.6.3.24] Nickel transport system Transporters 0 0 -K10824 nikE; nickel transport system ATP-binding protein [EC:3.6.3.24] Nickel transport system Transporters 0 0 -K15598 thiY; putative hydroxymethylpyrimidine transport system substrate-binding protein Putative hydroxymethylpyrimidine transport system Transporters 0 0 -K15599 thiX; putative hydroxymethylpyrimidine transport system permease protein Putative hydroxymethylpyrimidine transport system Transporters 0 0 -K15600 thiZ; putative hydroxymethylpyrimidine transport system ATP-binding protein Putative hydroxymethylpyrimidine transport system Transporters 0 0 -K03523 bioY; biotin transport system substrate-specific component Biotin transport system Transporters 0 0 -K16783 bioN; biotin transport system permease protein Biotin transport system Transporters 0 0 -K16784 bioM; biotin transport system ATP-binding protein [EC:3.6.3.-] Biotin transport system Transporters 0 0 -K03523 bioY; biotin transport system substrate-specific component Energy-coupling factor transport system Transporters 0 0 -K16923 qrtT; energy-coupling factor transport system substrate-specific component Energy-coupling factor transport system Transporters 0 0 -K16924 mtsT; energy-coupling factor transport system substrate-specific component Energy-coupling factor transport system Transporters 0 0 -K16925 ykoE; energy-coupling factor transport system substrate-specific component Energy-coupling factor transport system Transporters 0 0 -K16926 htsT; energy-coupling factor transport system substrate-specific component Energy-coupling factor transport system Transporters 0 0 -K16927 cbrT; energy-coupling factor transport system substrate-specific component Energy-coupling factor transport system Transporters 0 0 -K16928 mtaT; energy-coupling factor transport system substrate-specific component Energy-coupling factor transport system Transporters 0 0 -K16929 K16929; energy-coupling factor transport system substrate-specific component Energy-coupling factor transport system Transporters 0 0 -K16785 ecfT; energy-coupling factor transport system permease protein Energy-coupling factor transport system Transporters 0 0 -K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] Energy-coupling factor transport system Transporters 0 0 -K16787 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-] Energy-coupling factor transport system Transporters 0 0 -K16916 yydJ; putative peptide transport system permease protein Putative peptide transport system Transporters 0 0 -K16917 yydI; putative peptide transport system ATP-binding protein Putative peptide transport system Transporters 0 0 -K16918 ytrF; acetoin utilization transport system permease protein Acetoin utilization transport system Transporters 0 0 -K16919 ytrC_D; acetoin utilization transport system permease protein Acetoin utilization transport system Transporters 0 0 -K16920 ytrE; acetoin utilization transport system ATP-binding protein Acetoin utilization transport system Transporters 0 0 -K16921 ytrB; acetoin utilization transport system ATP-binding protein Acetoin utilization transport system Transporters 0 0 -K16956 tcyJ; L-cystine transport system substrate-binding protein L-Cystine transport system Transporters 0 0 -K16957 tcyK; L-cystine transport system substrate-binding protein L-Cystine transport system Transporters 0 0 -K16958 tcyL; L-cystine transport system permease protein L-Cystine transport system Transporters 0 0 -K16959 tcyM; L-cystine transport system permease protein L-Cystine transport system Transporters 0 0 -K16960 tcyN; L-cystine transport system ATP-binding protein [EC:7.4.2.1] L-Cystine transport system Transporters 0 0 -K16961 yxeM; putative S-methylcysteine transport system substrate-binding protein Putative S-methylcysteine transport system Transporters 0 0 -K16962 yxeN; putative S-methylcysteine transport system permease protein Putative S-methylcysteine transport system Transporters 0 0 -K16963 yxeO; putative S-methylcysteine transport system ATP-binding protein Putative S-methylcysteine transport system Transporters 0 0 -K17062 bgtB; arginine/lysine/histidine/glutamine transport system substrate-binding and permease protein Arginine/lysine/histidine/glutamine transport system Transporters 0 0 -K17063 bgtA; arginine/lysine/histidine/glutamine transport system ATP-binding protein Arginine/lysine/histidine/glutamine transport system Transporters 0 0 -K17073 lysX1; putative lysine transport system substrate-binding protein Putative lysine transport system Transporters 0 0 -K17074 lysX2; putative lysine transport system permease protein Putative lysine transport system Transporters 0 0 -K17076 lysY; putative lysine transport system ATP-binding protein [EC:7.4.2.1] Putative lysine transport system Transporters 0 0 -K17202 K17202; erythritol transport system substrate-binding protein Erythritol transport system Transporters 0 0 -K17203 K17203; erythritol transport system permease protein Erythritol transport system Transporters 0 0 -K17204 eryE; erythritol transport system ATP-binding protein [COGCOG1129] Erythritol transport system Transporters 0 0 -K17205 xltC; putative xylitol transport system substrate-binding protein Putative xylitol transport system Transporters 0 0 -K17206 xltB; putative xylitol transport system permease protein Putative xylitol transport system Transporters 0 0 -K17207 xltA; putative xylitol transport system ATP-binding protein Putative xylitol transport system Transporters 0 0 -K17208 K17208; inositol transport system substrate-binding protein Inositol transport system Transporters 0 0 -K17209 iatP; inositol transport system permease protein Inositol transport system Transporters 0 0 -K17210 iatA; inositol transport system ATP-binding protein Inositol transport system Transporters 0 0 -K17213 K17213; inositol transport system substrate-binding protein Inositol transport system Transporters 0 0 -K17214 K17214; inositol transport system permease protein Inositol transport system Transporters 0 0 -K17215 K17215; inositol transport system ATP-binding protein Inositol transport system Transporters 0 0 -K17237 inoE; inositol-phosphate transport system substrate-binding protein Inositol-phosphate transport system Transporters 0 0 -K17238 inoF; inositol-phosphate transport system permease protein Inositol-phosphate transport system Transporters 0 0 -K17239 inoG; inositol-phosphate transport system permease protein Inositol-phosphate transport system Transporters 0 0 -K17240 inoK; inositol-phosphate transport system ATP-binding protein Inositol-phosphate transport system Transporters 0 0 -K17241 aguE; alpha-1,4-digalacturonate transport system substrate-binding protein alpha-1,4-Digalacturonate transport system Transporters 0 0 -K17242 aguF; alpha-1,4-digalacturonate transport system permease protein alpha-1,4-Digalacturonate transport system Transporters 0 0 -K17243 aguG; alpha-1,4-digalacturonate transport system permease protein alpha-1,4-Digalacturonate transport system Transporters 0 0 -K17244 chiE; putative chitobiose transport system substrate-binding protein Putative chitobiose transport system Transporters 0 0 -K17245 chiF; putative chitobiose transport system permease protein Putative chitobiose transport system Transporters 0 0 -K17246 chiG; putative chitobiose transport system permease protein Putative chitobiose transport system Transporters 0 0 -K17234 araN; arabinosaccharide transport system substrate-binding protein Arabinosaccharide transport system Transporters 0 0 -K17235 araP; arabinosaccharide transport system permease protein Arabinosaccharide transport system Transporters 0 0 -K17236 araQ; arabinosaccharide transport system permease protein Arabinosaccharide transport system Transporters 0 0 -K10112 msmX; multiple sugar transport system ATP-binding protein Arabinosaccharide transport system Transporters 0 0 -K17318 lplA; putative aldouronate transport system substrate-binding protein Putative aldouronate transport system Transporters 0 0 -K17319 lplB; putative aldouronate transport system permease protein Putative aldouronate transport system Transporters 0 0 -K17320 lplC; putative aldouronate transport system permease protein Putative aldouronate transport system Transporters 0 0 -K17311 K17311; trehalose transport system substrate-binding protein Trehalose transport system Transporters 0 0 -K17312 K17312; trehalose transport system permease protein Trehalose transport system Transporters 0 0 -K17313 treU; trehalose transport system permease protein Trehalose transport system Transporters 0 0 -K17314 treV; trehalose transport system ATP-binding protein Trehalose transport system Transporters 0 0 -K17315 gtsA; glucose/mannose transport system substrate-binding protein Glucose/mannose transport system Transporters 0 0 -K17316 gtsB; glucose/mannose transport system permease protein Glucose/mannose transport system Transporters 0 0 -K17317 gtsC; glucose/mannose transport system permease protein Glucose/mannose transport system Transporters 0 0 -K10112 msmX; multiple sugar transport system ATP-binding protein Glucose/mannose transport system Transporters 0 0 -K17329 dasA; N,N'-diacetylchitobiose transport system substrate-binding protein N,N'-Diacetylchitobiose transport system Transporters 0 0 -K17330 dasB; N,N'-diacetylchitobiose transport system permease protein N,N'-Diacetylchitobiose transport system Transporters 0 0 -K17331 dasC; N,N'-diacetylchitobiose transport system permease protein N,N'-Diacetylchitobiose transport system Transporters 0 0 -K10112 msmX; multiple sugar transport system ATP-binding protein N,N'-Diacetylchitobiose transport system Transporters 0 0 -K17321 glpV; glycerol transport system substrate-binding protein Glycerol transport system Transporters 0 0 -K17322 glpP; glycerol transport system permease protein Glycerol transport system Transporters 0 0 -K17323 glpQ; glycerol transport system permease protein Glycerol transport system Transporters 0 0 -K17324 glpS; glycerol transport system ATP-binding protein Glycerol transport system Transporters 0 0 -K17325 glpT; glycerol transport system ATP-binding protein Glycerol transport system Transporters 0 0 -K17464 PTS-Dga-EIIA; PTS system, D-glucosaminate-specific IIA component PTS system, D-glucosaminate-specific II component Transporters 0 0 -K17465 PTS-Dga-EIIB; PTS system, D-glucosaminate-specific IIB component PTS system, D-glucosaminate-specific II component Transporters 0 0 -K17466 PTS-Dga-EIIC; PTS system, D-glucosaminate-specific IIC component PTS system, D-glucosaminate-specific II component Transporters 0 0 -K17467 PTS-Dga-EIID; PTS system, D-glucosaminate-specific IID component PTS system, D-glucosaminate-specific II component Transporters 0 0 -K17326 bxlE; xylobiose transport system substrate-binding protein Xylobiose transport system Transporters 0 0 -K17327 bxlF; xylobiose transport system permease protein Xylobiose transport system Transporters 0 0 -K17328 bxlG; xylobiose transport system permease protein Xylobiose transport system Transporters 0 0 -K18233 oleC5; oleandomycin transport system permease protein Oleandomycin transport system Transporters 0 1 -K18232 oleC4; oleandomycin transport system ATP-binding protein Oleandomycin transport system Transporters 0 0 -K18216 steA; ATP-binding cassette, subfamily B, tetracycline resistant protein Tetracycline resistance, TetAB(46) transporter Transporters 0 0 -K18217 steB; ATP-binding cassette, subfamily B, tetracycline resistant protein Tetracycline resistance, TetAB(46) transporter Transporters 0 0 -K18476 tetR; TetR/AcrR family transcriptional regulator, tetracycline repressor protein Tetracycline resistance, TetA transporter Transporters 0 0 -K08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein Tetracycline resistance, TetA transporter Transporters 0 0 -K02067 mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein gamma-Hexachlorocyclohexane transport system Transporters 0 0 -K02066 mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein gamma-Hexachlorocyclohexane transport system Transporters 0 0 -K02065 mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein gamma-Hexachlorocyclohexane transport system Transporters 0 0 -K18480 linN; cholesterol transport system auxiliary component gamma-Hexachlorocyclohexane transport system Transporters 0 0 -K02067 mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein Mce transport system Transporters 0 0 -K02066 mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein Mce transport system Transporters 0 0 -K02065 mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein Mce transport system Transporters 0 0 -K18481 mas; Mce-associated membrane protein Mce transport system Transporters 0 0 -K19083 braD; bacitracin transport system ATP-binding protein Bacitracin resistance, VraDE transporter Transporters 0 0 -K19084 braE; bacitracin transport system permease protein Bacitracin resistance, VraDE transporter Transporters 0 0 -K19081 braS; two-component system, OmpR family, sensor histidine kinase BraS/BceS [EC:2.7.13.3] Bacitracin resistance, VraDE transporter Transporters 0 0 -K19082 braR; two-component system, OmpR family, response regulator protein BraR/BceR Bacitracin resistance, VraDE transporter Transporters 0 0 -K11631 bceA; bacitracin transport system ATP-binding protein Bacitracin resistance, VraDE transporter Transporters 0 0 -K11632 bceB; bacitracin transport system permease protein Bacitracin resistance, VraDE transporter Transporters 0 0 -K11629 bceS; two-component system, OmpR family, bacitracin resistance sensor histidine kinase BceS [EC:2.7.13.3] Bacitracin resistance, BceAB transporter Transporters 0 0 -K11630 bceR; two-component system, OmpR family, bacitracin resistance response regulator BceR Bacitracin resistance, BceAB transporter Transporters 0 0 -K11631 bceA; bacitracin transport system ATP-binding protein Bacitracin resistance, BceAB transporter Transporters 0 0 -K11632 bceB; bacitracin transport system permease protein Bacitracin resistance, BceAB transporter Transporters 0 0 -K19226 sapA; cationic peptide transport system substrate-binding protein Cationic peptide transport system Transporters 0 0 -K19227 sapB; cationic peptide transport system permease protein Cationic peptide transport system Transporters 0 0 -K19228 sapC; cationic peptide transport system permease protein Cationic peptide transport system Transporters 0 0 -K19229 sapD; cationic peptide transport system ATP-binding protein Cationic peptide transport system Transporters 0 0 -K19230 sapF; cationic peptide transport system ATP-binding protein Cationic peptide transport system Transporters 0 0 -K19506 PTS-Gfr-EIIA; PTS system, fructoselysine/glucoselysine-specific IIA component PTS system, fructoselysine/glucoselysine-specific II component Transporters 0 0 -K19507 PTS-Gfr-EIIB; PTS system, fructoselysine/glucoselysine-specific IIB component PTS system, fructoselysine/glucoselysine-specific II component Transporters 0 0 -K19508 PTS-Gfr-EIIC; PTS system, fructoselysine/glucoselysine-specific IIC component PTS system, fructoselysine/glucoselysine-specific II component Transporters 0 0 -K19509 PTS-Gfr-EIID; PTS system, fructoselysine/glucoselysine-specific IID component PTS system, fructoselysine/glucoselysine-specific II component Transporters 0 0 -K19971 psaA; manganese/zinc transport system substrate-binding protein Manganese/zinc transport system Transporters 0 0 -K19972 psaC; manganese/zinc transport system permease protein Manganese/zinc transport system Transporters 0 0 -K10830 psaB; manganese/zinc transport system ATP-binding protein [EC:3.6.3.35] Manganese/zinc transport system Transporters 0 0 -K19975 mntC; manganese/zinc transport system substrate-binding protein Manganese/zinc transport system Transporters 0 0 -K19976 mntB; manganese/zinc transport system permease protein Manganese/zinc transport system Transporters 0 0 -K19973 mntA; manganese/zinc transport system ATP-binding protein [EC:3.6.3.35] Manganese/zinc transport system Transporters 0 0 -K02777 PTS-Glc-EIIA; PTS system, glucose-specific IIA component PTS system, maltose-specific II component Transporters 0 0 -K20107 PTS-Mal-EIIB; PTS system, maltose-specific IIB component PTS system, maltose-specific II component Transporters 0 0 -K20108 PTS-Mal-EIIC; PTS system, maltose-specific IIC component PTS system, maltose-specific II component Transporters 0 0 -K20112 PTS-Gal-EIIA; PTS system, galactose-specific IIA component PTS system, galactose-specific II component Transporters 0 0 -K20113 PTS-Gal-EIIB; PTS system, galactose-specific IIB component PTS system, galactose-specific II component Transporters 0 0 -K20114 PTS-Gal-EIIC; PTS system, galactose-specific IIC component PTS system, galactose-specific II component Transporters 0 0 -K20116 PTS-Glc1-EIIA; PTS system, glucose-specific IIA component PTS system, glucose-specific II component Transporters 0 0 -K20117 PTS-Glc1-EIIB; PTS system, glucose-specific IIB component PTS system, glucose-specific II component Transporters 0 0 -K20118 PTS-Glc1-EIIC; PTS system, glucose-specific IIC component PTS system, glucose-specific II component Transporters 0 0 -K20459 nukF; lantibiotic transport system ATP-binding protein Lantibiotic transport system Transporters 0 0 -K20460 nukE; lantibiotic transport system permease protein Lantibiotic transport system Transporters 0 0 -K20461 nukG; lantibiotic transport system permease protein Lantibiotic transport system Transporters 0 0 -K20491 nisE; lantibiotic transport system permease protein Lantibiotic transport system Transporters 0 0 -K20492 nisG; lantibiotic transport system permease protein Lantibiotic transport system Transporters 0 0 -K20494 epiG; lantibiotic transport system permease protein Lantibiotic transport system Transporters 0 0 -K20490 nisF; lantibiotic transport system ATP-binding protein Lantibiotic transport system Transporters 0 0 -K23055 putative lysine/arginine/ornithine/histidine/octopine transport system substrate-binding protein Putative lysine/arginine/ornithine/histidine/octopine transport system Transporters 0 0 -K23056 putative lysine/arginine/ornithine/histidine/octopine transport system permease protein Putative lysine/arginine/ornithine/histidine/octopine transport system Transporters 0 0 -K23057 putative lysine/arginine/ornithine/histidine/octopine transport system permease protein Putative lysine/arginine/ornithine/histidine/octopine transport system Transporters 0 0 -K23058 putative lysine/arginine/ornithine/histidine/octopine transport system ATPase-binding protein [EC:7.4.2.1] Putative lysine/arginine/ornithine/histidine/octopine transport system Transporters 0 0 -K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1] Arginine/lysine/histidine transport system Transporters 0 0 -K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein Arginine/lysine/histidine transport system Transporters 0 0 -K17077 artQ; arginine/lysine/histidine transport system permease protein Arginine/lysine/histidine transport system Transporters 0 0 -K23061 lhpP; hydroxyproline transporter system substrate-binding protein Hydroxyproline transporter system Transporters 0 0 -K23062 lhpM; hydroxyproline transport system permease protein Hydroxyproline transporter system Transporters 0 0 -K23063 lhpN; hydroxyproline transport system permease protein Hydroxyproline transporter system Transporters 0 0 -K23064 lhpO; hydroxyproline transport system ATP-binding protein [EC:7.4.2.1] Hydroxyproline transporter system Transporters 0 0 -K15495 wtpC; molybdate/tungstate transport system substrate-binding protein Molybdate/tungstate transport system Transporters 0 0 -K15496 wtpB; molybdate/tungstate transport system permease protein Molybdate/tungstate transport system Transporters 0 0 -K15497 wtpA; molybdate/tungstate transport system ATP-binding protein [EC:3.6.3.-] Molybdate/tungstate transport system Transporters 0 0 -K16199 dppE; dipeptide transport system substrate-binding protein Dipeptide transport system, Firmicutes Transporters 0 0 -K16200 dppB1; dipeptide transport system permease protein Dipeptide transport system, Firmicutes Transporters 0 0 -K16201 dppC1; dipeptide transport system permease protein Dipeptide transport system, Firmicutes Transporters 0 0 -K16202 dppD1; dipeptide transport system ATP-binding protein Dipeptide transport system, Firmicutes Transporters 0 0 diff --git a/workflows/dram.nf b/workflows/dram.nf index 5ca9060e..bf17269b 100644 --- a/workflows/dram.nf +++ b/workflows/dram.nf @@ -36,9 +36,9 @@ workflow DRAM { // Setup // - ch_versions = Channel.empty() - ch_multiqc_files = Channel.empty() - ch_fasta = Channel.empty() + ch_versions = channel.empty() + ch_multiqc_files = channel.empty() + ch_fasta = channel.empty() default_sheet = file(params.distill_dummy_sheet) distill_flag = (params.summarize || params.distill_topic != "" || params.distill_ecosystem != "" || params.distill_custom != "" || params.sum_ecos != "") @@ -60,14 +60,11 @@ workflow DRAM { if (params.rename || call) { - ch_fasta = Channel + ch_fasta = channel .fromPath(file(params.input_fasta) / params.fasta_fmt, checkIfExists: true) .ifEmpty { exit 1, "Cannot find any fasta files matching: ${params.input_fasta}\nNB: Path needs to follow pattern: path/to/directory/" } - ch_fasta = ch_fasta.map { - fasta_name = it.getBaseName() - tuple(fasta_name, it) - } + ch_fasta = ch_fasta.map { it -> [ it.getBaseName(), it ] } } use_kegg = params.use_kegg @@ -85,7 +82,7 @@ workflow DRAM { use_vog = params.use_vog if (params.anno_dbs != "") { - anno_dbs = params.anno_dbs.tokenize(',').collect { it.trim().toLowerCase() } + anno_dbs = params.anno_dbs.tokenize(',').collect { it -> it.trim().toLowerCase() } value_for_all = 'all' use_kegg = getDBFlag(anno_dbs, 'kegg', value_for_all) use_kofam = getDBFlag(anno_dbs, 'kofam', value_for_all) @@ -234,6 +231,7 @@ workflow DRAM { use_vog ) + if (params.annotate){ // If the user has specified --annotate, us the outputted annotations ch_final_annots = ANNOTATE.out.ch_combined_annotations if( params.add_annotations ){ @@ -284,24 +282,24 @@ workflow DRAM { // // MODULE: MultiQC // - ch_multiqc_config = Channel.fromPath( + ch_multiqc_config = channel.fromPath( "$projectDir/assets/multiqc_config.yml", checkIfExists: true) ch_multiqc_custom_config = params.multiqc_config ? - Channel.fromPath(params.multiqc_config, checkIfExists: true) : - Channel.empty() + channel.fromPath(params.multiqc_config, checkIfExists: true) : + channel.empty() ch_multiqc_logo = params.multiqc_logo ? - Channel.fromPath(params.multiqc_logo, checkIfExists: true) : - Channel.empty() + channel.fromPath(params.multiqc_logo, checkIfExists: true) : + channel.empty() summary_params = paramsSummaryMap( workflow, parameters_schema: "nextflow_schema.json") - ch_workflow_summary = Channel.value(paramsSummaryMultiqc(summary_params)) + ch_workflow_summary = channel.value(paramsSummaryMultiqc(summary_params)) ch_multiqc_files = ch_multiqc_files.mix( ch_workflow_summary.collectFile(name: 'workflow_summary_mqc.yaml')) ch_multiqc_custom_methods_description = params.multiqc_methods_description ? file(params.multiqc_methods_description, checkIfExists: true) : file("$projectDir/assets/methods_description_template.yml", checkIfExists: true) - ch_methods_description = Channel.value( + ch_methods_description = channel.value( methodsDescriptionText(ch_multiqc_custom_methods_description)) ch_multiqc_files = ch_multiqc_files.mix(ch_collated_versions)