diff --git a/packages/rxjs/src/combine-latest.ts b/packages/rxjs/src/combine-latest.ts
index 31494372a3..f36106e08b 100644
--- a/packages/rxjs/src/combine-latest.ts
+++ b/packages/rxjs/src/combine-latest.ts
@@ -12,14 +12,15 @@ type CombineLatestArrayValues<Sources extends readonly ObservableValue<any>[]> =
 
 export const combineLatest: unique symbol = Symbol('combineLatest');
 
+// The empty-tuple constraints preserve array-literal positions without requiring `as const`.
 declare global {
   interface ObservableCtor {
     [combineLatest]: {
-      <Sources extends readonly ObservableValue<any>[] | { [key: string]: ObservableValue<any> }>(
+      <Sources extends readonly ObservableValue<any>[] | readonly [] | { [key: string]: ObservableValue<any> }>(
         sources: Sources,
         config?: { requireAllValues?: boolean }
       ): Observable<CombineLatestValues<Sources>>;
-      <Sources extends readonly ObservableValue<any>[], Result>(
+      <Sources extends readonly ObservableValue<any>[] | readonly [], Result>(
         sources: Sources,
         project: (...values: CombineLatestArrayValues<Sources>) => Result
       ): Observable<Result>;
@@ -28,10 +29,11 @@ declare global {
 
   interface Observable<T> {
     [combineLatest]: {
-      <Sources extends readonly ObservableValue<any>[]>(sources: Sources, config?: { requireAllValues?: boolean }): Observable<
-        [T, ...CombineLatestArrayValues<Sources>]
-      >;
-      <Sources extends readonly ObservableValue<any>[], Result>(
+      <Sources extends readonly ObservableValue<any>[] | readonly []>(
+        sources: Sources,
+        config?: { requireAllValues?: boolean }
+      ): Observable<[T, ...CombineLatestArrayValues<Sources>]>;
+      <Sources extends readonly ObservableValue<any>[] | readonly [], Result>(
         sources: Sources,
         project: (value: T, ...values: CombineLatestArrayValues<Sources>) => Result
       ): Observable<Result>;
diff --git a/packages/rxjs/test/types/combine-latest.ts b/packages/rxjs/test/types/combine-latest.ts
new file mode 100644
index 0000000000..620a656d7e
--- /dev/null
+++ b/packages/rxjs/test/types/combine-latest.ts
@@ -0,0 +1,46 @@
+import 'rxjs';
+import { combineLatest } from 'rxjs/combine-latest';
+
+type Equal<A, B> = (<T>() => T extends A ? 1 : 2) extends <T>() => T extends B ? 1 : 2 ? true : false;
+type Assert<T extends true> = T;
+
+declare const a: Observable<number>;
+declare const b: Observable<string>;
+declare const receiver: Observable<boolean>;
+declare const array: (Observable<number> | Observable<string>)[];
+declare const readonlyArray: readonly (Observable<number> | Observable<string>)[];
+
+const tuple = Observable[combineLatest]([a, b]);
+type Tuple = Assert<Equal<typeof tuple, Observable<[number, string]>>>;
+tuple.subscribe(([n, s]) => {
+  const x: number = n;
+  const y: string = s;
+});
+
+const configured = Observable[combineLatest]([a, b], { requireAllValues: true });
+type Configured = Assert<Equal<typeof configured, Observable<[number, string]>>>;
+
+const readonlyTuple = Observable[combineLatest]([a, b] as const);
+type ReadonlyTuple = Assert<Equal<typeof readonlyTuple, Observable<readonly [number, string]>>>;
+
+const arrayResult = Observable[combineLatest](array);
+type ArrayResult = Assert<Equal<typeof arrayResult, Observable<(number | string)[]>>>;
+const readonlyArrayResult = Observable[combineLatest](readonlyArray);
+type ReadonlyArrayResult = Assert<Equal<typeof readonlyArrayResult, Observable<readonly (number | string)[]>>>;
+
+const object = Observable[combineLatest]({ count: a, label: b });
+type ObjectResult = Assert<Equal<typeof object, Observable<{ count: number; label: string }>>>;
+
+const empty = Observable[combineLatest]([]);
+type Empty = Assert<Equal<typeof empty, Observable<[]>>>;
+
+const projected = Observable[combineLatest]([a, b], (n, s) => n.toFixed() + s.toUpperCase());
+type Projected = Assert<Equal<typeof projected, Observable<string>>>;
+
+const instance = receiver[combineLatest]([a, b]);
+type Instance = Assert<Equal<typeof instance, Observable<[boolean, number, string]>>>;
+const instanceProjected = receiver[combineLatest]([a, b], (enabled, n, s) => (enabled ? n.toFixed() + s.toUpperCase() : ''));
+type InstanceProjected = Assert<Equal<typeof instanceProjected, Observable<string>>>;
+
+// @ts-expect-error Each source must be an ObservableValue.
+Observable[combineLatest]([a, 42]);