247704/readme.html at master · ModelDBRepository/247704 · GitHub

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
<HTML>


The XPPAUT code for the paper:<br>

<b>
Y.Liu, J. Milton and S.A. Campbell (2019) </b>
Outgrowing seizures in Childhood Absence Epilepsy: time delays and bistability
Journal of Computational Neuroscience,
<a href="https://doi.org/10.1007/s10827-019-00711-x">doi:10.1007/s10827-019-00711-x</a>.

<p>
Details on installing XPPAUT can be found on
<a href="http://www.math.pitt.edu/~bard/xpp/xpp.html">Bard Ermentrout's XPPAUT webpage</a>.
</p>

To reproduce figures in paper, all parameters can be left at default
values: (Initialconds -> Go)<p/>
   <img src="./screenshot.png" alt="screenshot 0" width="550"><p/>

except as follows.
<dl>
<dt><b>Figure 2</b>: (use Parameters menu, type variable name, value) (type escape key "esc" when done/ready to run the model) gd_AMPA=0,ge_AMPA=0.
 <dd>Left: Itc_ext_c=5;
   <p/>
   <img src="./screenshot1.png" alt="screenshot 1" width="550"><p/>
Right: Itc_ext_c=6<p/> Top gb_GABAA=0.6;
<dd>
   <img src="./screenshot2.png" alt="screenshot 2" width="550"><p/>
   Bottom: gb_GABAA=0.1
<dd>   <img src="./screenshot3.png" alt="screenshot 3" width="550"><p/>
   Middle gb_GABAA=0.3;
<dd>   <img src="./screenshot4.png" alt="screenshot 4" width="550"><p/>
<dt><b>Figure 3</b>: gd_AMPA=0,ge_AMPA=0.
 <dd>Itc_ext_c=5, Itc_pert=1.5, ontime=2000, offtime=2500
 <dd>Left gb_GABAA=0.1; Middle gb_GABAA=0.4; Right: gb_GABAA=0.7

<dt><b>Figure 4</b>: Itc_ext=5, tau1=9, tau2=2.8
 <dd>Top left gb_GABAA=0.6; Top right gb_GABAA=0.1;
 <dd> Bottom left: gb_GABAA=0.29; Bottom right: gb_GABAA=0.2;

<dt><b>Figure 5</b>: Itc_ext_c=5, tau2=2.8
 <dd>Left  gb_GABAA=0.6, tau1=4.2
 <dd>Right gb_GABAA=0.5, tau1=8.4

<dt><b>Figure 6</b>: Itc_ext_c=5, tau2=2.8, Itc_pert=1, ontime=2000, offtime=2300
 <dd>Left gb_GABAA=0.7; Right: gb_GABAA=0.4
 <dd>Top tau1=8.4; Bottom: tau1=2.8
</dl>

To modify the initial conditions for Figure 6 as described on page 7
of the paper, use the "delay ICs" window in XPPAUT.
</html>