From d40454811c7bd173dbe2f9b644b029c798c0770e Mon Sep 17 00:00:00 2001 From: EnfxcFCb6 Date: Wed, 9 Jul 2025 16:13:22 -0400 Subject: [PATCH 1/2] Standardized README to Markdown format --- index.html => README.md | 86 +++++++++++++++++++++-------------------- 1 file changed, 44 insertions(+), 42 deletions(-) rename index.html => README.md (57%) diff --git a/index.html b/README.md similarity index 57% rename from index.html rename to README.md index b31a4a4..a05ce02 100644 --- a/index.html +++ b/README.md @@ -1,51 +1,53 @@ -
-For the paper:
-
-Platkiewicz J, Brette R (2011) Impact of fast sodium channel
-inactivation on spike threshold dynamics and synaptic
-integration. PLoS Comput Biol 7:e1001129-78
-
-Abstract:
-
-Neurons spike when their membrane potential exceeds a threshold
-value. In central neurons, the spike threshold is not constant but
-depends on the stimulation. Thus, input-output properties of neurons
-depend both on the effect of presynaptic spikes on the membrane
-potential and on the dynamics of the spike threshold. Among the
-possible mechanisms that may modulate the threshold, one strong
-candidate is Na channel inactivation, because it specifically impacts
-spike initiation without affecting the membrane potential. We
-collected voltage-clamp data from the literature and we found, based
-on a theoretical criterion, that the properties of Na inactivation
-could indeed cause substantial threshold variability by itself. By
-analyzing simple neuron models with fast Na inactivation (one channel
-subtype), we found that the spike threshold is correlated with the
-mean membrane potential and negatively correlated with the preceding
-depolarization slope, consistent with experiments. We then analyzed
-the impact of threshold dynamics on synaptic integration. The
-difference between the postsynaptic potential (PSP) and the dynamic
-threshold in response to a presynaptic spike defines an effective
-PSP. When the neuron is sufficiently depolarized, this effective PSP
-is briefer than the PSP. This mechanism regulates the temporal window
-of synaptic integration in an adaptive way. Finally, we discuss the
-role of other potential mechanisms. Distal spike initiation, channel
-noise and Na activation dynamics cannot account for the observed
-negative slope-threshold relationship, while adaptive conductances
-(e.g. K+) and Na inactivation can. We conclude that Na inactivation is
-a metabolically efficient mechanism to control the temporal resolution
+# For the paper:
+
+Platkiewicz J, Brette R (2011) Impact of fast sodium channel  
+inactivation on spike threshold dynamics and synaptic  
+integration. *PLoS Comput Biol* 7:e1001129-78
+
+## Abstract:
+
+Neurons spike when their membrane potential exceeds a threshold  
+value. In central neurons, the spike threshold is not constant but  
+depends on the stimulation. Thus, input-output properties of neurons  
+depend both on the effect of presynaptic spikes on the membrane  
+potential and on the dynamics of the spike threshold. Among the  
+possible mechanisms that may modulate the threshold, one strong  
+candidate is Na channel inactivation, because it specifically impacts  
+spike initiation without affecting the membrane potential. We  
+collected voltage-clamp data from the literature and we found, based  
+on a theoretical criterion, that the properties of Na inactivation  
+could indeed cause substantial threshold variability by itself. By  
+analyzing simple neuron models with fast Na inactivation (one channel  
+subtype), we found that the spike threshold is correlated with the  
+mean membrane potential and negatively correlated with the preceding  
+depolarization slope, consistent with experiments. We then analyzed  
+the impact of threshold dynamics on synaptic integration. The  
+difference between the postsynaptic potential (PSP) and the dynamic  
+threshold in response to a presynaptic spike defines an effective  
+PSP. When the neuron is sufficiently depolarized, this effective PSP  
+is briefer than the PSP. This mechanism regulates the temporal window  
+of synaptic integration in an adaptive way. Finally, we discuss the  
+role of other potential mechanisms. Distal spike initiation, channel  
+noise and Na activation dynamics cannot account for the observed  
+negative slope-threshold relationship, while adaptive conductances  
+(e.g. K+) and Na inactivation can. We conclude that Na inactivation is  
+a metabolically efficient mechanism to control the temporal resolution  
 of synaptic integration.
 
 Brian simulator models are available at this web page:
 
-http://briansimulator.org/docs/examples-frompapers_Platkiewicz_Brette_2011.html
+[http://briansimulator.org/docs/examples-frompapers_Platkiewicz_Brette_2011.html](http://briansimulator.org/docs/examples-frompapers_Platkiewicz_Brette_2011.html)
 
 The simulation generates images similar to Fig. 5E,F in the paper:
 
-screenshot1
+![screenshot1](./screenshot1.png)
 
-This simulation requires Brian which can be downloaded and installed
-from the instructions available at http://www.briansimulator.org/
+This simulation requires Brian which can be downloaded and installed  
+from the instructions available at [http://www.briansimulator.org/](http://www.briansimulator.org/)
 
-For support on installing and using Brian simulations there is a
-support group at https://groups.google.com/group/briansupport.
-
+For support on installing and using Brian simulations there is a +support group at [https://groups.google.com/group/briansupport](https://groups.google.com/group/briansupport). + +--- + +2025-07-09: Converted README to Markdown. \ No newline at end of file From 1c35591d2fb99891632b5facb52d127660d5689d Mon Sep 17 00:00:00 2001 From: rsakai Date: Thu, 10 Jul 2025 15:42:12 -0400 Subject: [PATCH 2/2] Update README.md --- README.md | 62 +++++++++++++++++++++++++++---------------------------- 1 file changed, 31 insertions(+), 31 deletions(-) diff --git a/README.md b/README.md index a05ce02..5ad876b 100644 --- a/README.md +++ b/README.md @@ -1,37 +1,37 @@ # For the paper: -Platkiewicz J, Brette R (2011) Impact of fast sodium channel -inactivation on spike threshold dynamics and synaptic +Platkiewicz J, Brette R (2011) Impact of fast sodium channel +inactivation on spike threshold dynamics and synaptic integration. *PLoS Comput Biol* 7:e1001129-78 ## Abstract: -Neurons spike when their membrane potential exceeds a threshold -value. In central neurons, the spike threshold is not constant but -depends on the stimulation. Thus, input-output properties of neurons -depend both on the effect of presynaptic spikes on the membrane -potential and on the dynamics of the spike threshold. Among the -possible mechanisms that may modulate the threshold, one strong -candidate is Na channel inactivation, because it specifically impacts -spike initiation without affecting the membrane potential. We -collected voltage-clamp data from the literature and we found, based -on a theoretical criterion, that the properties of Na inactivation -could indeed cause substantial threshold variability by itself. By -analyzing simple neuron models with fast Na inactivation (one channel -subtype), we found that the spike threshold is correlated with the -mean membrane potential and negatively correlated with the preceding -depolarization slope, consistent with experiments. We then analyzed -the impact of threshold dynamics on synaptic integration. The -difference between the postsynaptic potential (PSP) and the dynamic -threshold in response to a presynaptic spike defines an effective -PSP. When the neuron is sufficiently depolarized, this effective PSP -is briefer than the PSP. This mechanism regulates the temporal window -of synaptic integration in an adaptive way. Finally, we discuss the -role of other potential mechanisms. Distal spike initiation, channel -noise and Na activation dynamics cannot account for the observed -negative slope-threshold relationship, while adaptive conductances -(e.g. K+) and Na inactivation can. We conclude that Na inactivation is -a metabolically efficient mechanism to control the temporal resolution +Neurons spike when their membrane potential exceeds a threshold +value. In central neurons, the spike threshold is not constant but +depends on the stimulation. Thus, input-output properties of neurons +depend both on the effect of presynaptic spikes on the membrane +potential and on the dynamics of the spike threshold. Among the +possible mechanisms that may modulate the threshold, one strong +candidate is Na channel inactivation, because it specifically impacts +spike initiation without affecting the membrane potential. We +collected voltage-clamp data from the literature and we found, based +on a theoretical criterion, that the properties of Na inactivation +could indeed cause substantial threshold variability by itself. By +analyzing simple neuron models with fast Na inactivation (one channel +subtype), we found that the spike threshold is correlated with the +mean membrane potential and negatively correlated with the preceding +depolarization slope, consistent with experiments. We then analyzed +the impact of threshold dynamics on synaptic integration. The +difference between the postsynaptic potential (PSP) and the dynamic +threshold in response to a presynaptic spike defines an effective +PSP. When the neuron is sufficiently depolarized, this effective PSP +is briefer than the PSP. This mechanism regulates the temporal window +of synaptic integration in an adaptive way. Finally, we discuss the +role of other potential mechanisms. Distal spike initiation, channel +noise and Na activation dynamics cannot account for the observed +negative slope-threshold relationship, while adaptive conductances +(e.g. K+) and Na inactivation can. We conclude that Na inactivation is +a metabolically efficient mechanism to control the temporal resolution of synaptic integration. Brian simulator models are available at this web page: @@ -42,12 +42,12 @@ The simulation generates images similar to Fig. 5E,F in the paper: ![screenshot1](./screenshot1.png) -This simulation requires Brian which can be downloaded and installed +This simulation requires Brian which can be downloaded and installed from the instructions available at [http://www.briansimulator.org/](http://www.briansimulator.org/) -For support on installing and using Brian simulations there is a +For support on installing and using Brian simulations there is a support group at [https://groups.google.com/group/briansupport](https://groups.google.com/group/briansupport). --- -2025-07-09: Converted README to Markdown. \ No newline at end of file +2025-07-09: Converted README to Markdown.