diff --git a/.zenodo.json b/.zenodo.json index 3fa14e6..2e0ac1c 100644 --- a/.zenodo.json +++ b/.zenodo.json @@ -1,21 +1,30 @@ { - "title": "PathoNiche Resolver-Window: Analysis Code and Derived Data for Liver Fibrosis Regression Resistance", + "title": "Source data and analysis code for Stellate-cell retention progressively occupies liver scar and constricts repair interfaces", "upload_type": "software", - "publication_date": "2026-07-16", - "description": "Analysis-code snapshots, non-identifying aggregate clinical results, public-data-derived molecular and spatial results, and publication figures supporting the manuscript 'A resolver-window imbalance links stellate-cell scar occupation to liver fibrosis regression resistance.' The clinical component contains no participant-level records or identifiers. Large public raw datasets are referenced by accession and are not redistributed. Code is MIT licensed; author-owned documentation, figures, and derived tabular outputs are CC BY 4.0.", + "description": "Non-identifying aggregate clinical tables, public-data-derived molecular and spatial results, audit records, analysis-code snapshots, and revised publication figures supporting progressive stellate-cell occupation of liver scar and contraction of repair interfaces.", "creators": [ - {"name": "Ying, Hongyu", "affiliation": "Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}, + {"name": "Ying, Hongyu", "affiliation": "Shanghai Pudong Hospital, Fudan University Pudong Medical Center", "orcid": "0009-0002-0072-3033"}, {"name": "Zhang, Ze", "affiliation": "Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}, {"name": "Qiao, Chunping", "affiliation": "Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}, - {"name": "Dong, Chang", "affiliation": "Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}, + {"name": "Chang, Dong", "affiliation": "Shanghai Pudong Hospital, Fudan University Pudong Medical Center"}, {"name": "Yu, Hong-wei", "affiliation": "Shanghai Pudong Hospital, Fudan University Pudong Medical Center"} ], - "keywords": ["liver fibrosis", "hepatic stellate cells", "spatial transcriptomics", "MASLD", "fibrosis regression", "resolver window", "single-cell transcriptomics", "transient elastography", "LINCS L1000", "reproducible research"], - "license": "MIT", + "keywords": [ + "liver fibrosis", + "hepatic stellate cell", + "spatial transcriptomics", + "regression resistance", + "resolver window", + "MASLD" + ], + "license": "cc-by-4.0", "access_right": "open", - "version": "1.1.0", + "version": "2.1.0", "related_identifiers": [ - {"identifier": "https://github.com/LightChainr/PathoNiche-ResolverWindow", "relation": "isSupplementTo", "scheme": "url"} - ], - "notes": "Dual-license release: MIT for code; CC BY 4.0 for author-owned documentation, figures, and derived tabular outputs. Supported by National Natural Science Foundation of China grant 82473682 and Project of Key Medical Specialty and Treatment Center of Pudong grant PWZxk2022-08." + { + "identifier": "https://github.com/LightChainr/PathoNiche-ResolverWindow", + "relation": "isSupplementTo", + "scheme": "url" + } + ] } diff --git a/CHANGELOG.md b/CHANGELOG.md index 6d3ace1..12b41b1 100644 --- a/CHANGELOG.md +++ b/CHANGELOG.md @@ -1,12 +1,33 @@ # Changelog -## 1.1.0 - 2026-07-16 - -- Published the stable public research-companion release. -- Added the Zenodo DOI `10.5281/zenodo.21388386` and GitHub repository URL. -- Corrected machine-readable creator metadata for Chang Dong. -- Added seven final main figures in PNG, PDF, and editable SVG formats to the archived release. -- Added Supplementary Figures S1–S29 to the archived release. -- Added figure-to-source mapping, data governance documentation, and deterministic release validation. +## 2.1.0-rc1 - 2026-08-28 + +- Rebuilt Figures 1, 2, 5, and 7 as editable, terminology-aligned SVG/PDF/PNG plates. +- Added coordinate-only UQ biopsy reconstruction, six mapping scenarios, leave-one-array-out tests, and Supplementary Figure S30. +- Added an evidence-coded 24-edge mechanism circuit with literature-established, project-supported, and candidate classes. +- Added environment locks, clean Python validation, deterministic image rebuild comparisons, privacy checks, and exact release manifests. +- Expanded the release to seven main figures and Supplementary Figures S1-S30. +- Aligned manuscript methods, legends, panel provenance, data dictionary, workflow entry points, and release metadata. + +## 2.0.0-rc1 - 2026-08-27 + +- Added a panel-level reproducibility audit and dated analysis chronology. +- Added GSE306327 structure, UQ reconstruction, and complete drug-order scoring records. +- Rebuilt Figures 3, 4, 6, and 7 to remove incompatible scales, pseudo-replicated stage trends, unestimated dynamical quantities, and treatment-order language that exceeded the computation. +- Added a self-contained script and compact inputs for the four replacement panels. +- Reframed the four predictions as the final analytical organization rather than prospective preregistration. +- Declared biological and technical units for the clinical, mouse, pooled-library, Visium, CODEX, and LINCS analyses. + +## 1.1.0-rc1 - 2026-07-16 + +- Aligned repository title and documentation with the JCTH-directed manuscript. +- Added seven final main figures in PNG, PDF, and SVG formats. +- Added Supplementary Figures S1-S29. +- Added figure-to-source mapping and a public-release checklist. +- Added a deterministic release validator and numerical-anchor audit. - Retained only aggregate proprietary clinical outputs and public-data-derived results. -- Excluded manuscript drafts, ethics files, author contact files, clinical linkage material, credentials, raw public archives, and model weights. +- Excluded manuscript drafts, AI-generated concept art, ethics files, author contact files, clinical linkage material, credentials, and raw public archives. + +## 1.0.0-rc1 - 2026-07-13 + +- Initial privacy-screened source-data and code release candidate. diff --git a/CITATION.bib b/CITATION.bib deleted file mode 100644 index c00c71d..0000000 --- a/CITATION.bib +++ /dev/null @@ -1,10 +0,0 @@ -@software{ying_pathoniche_2026, - author = {Ying, Hongyu and Zhang, Ze and Qiao, Chunping and Dong, Chang and Yu, Hong-wei}, - title = {PathoNiche Resolver-Window: Analysis Code and Derived Data for Liver Fibrosis Regression Resistance}, - month = jul, - year = 2026, - publisher = {Zenodo}, - version = {1.1.0}, - doi = {10.5281/zenodo.21388386}, - url = {https://doi.org/10.5281/zenodo.21388386} -} diff --git a/CITATION.cff b/CITATION.cff index ec514bf..2cb89f7 100644 --- a/CITATION.cff +++ b/CITATION.cff @@ -1,12 +1,9 @@ cff-version: 1.2.0 -message: "Please cite this software release and the associated manuscript." -title: "PathoNiche Resolver-Window: Analysis Code and Derived Data for Liver Fibrosis Regression Resistance" +message: "Please cite the associated manuscript and this archived release." +title: "Source data and analysis code for Stellate-cell retention progressively occupies liver scar and constricts repair interfaces" type: software -version: 1.1.0 -date-released: 2026-07-16 -doi: 10.5281/zenodo.21388386 -url: "https://doi.org/10.5281/zenodo.21388386" -repository-code: "https://github.com/LightChainr/PathoNiche-ResolverWindow" +version: 2.1.0 +date-released: 2026-08-28 authors: - family-names: Ying given-names: Hongyu @@ -17,18 +14,22 @@ authors: - family-names: Qiao given-names: Chunping affiliation: "Shanghai Pudong Hospital, Fudan University Pudong Medical Center" - - family-names: Dong - given-names: Chang + - family-names: Chang + given-names: Dong affiliation: "Shanghai Pudong Hospital, Fudan University Pudong Medical Center" - family-names: Yu given-names: Hong-wei affiliation: "Shanghai Pudong Hospital, Fudan University Pudong Medical Center" keywords: - liver fibrosis - - hepatic stellate cells + - hepatic stellate cell - spatial transcriptomics - - fibrosis regression + - regression resistance - resolver window - MASLD - - reproducible research -license: MIT +license: CC-BY-4.0 +repository-code: "https://github.com/LightChainr/PathoNiche-ResolverWindow" +identifiers: + - type: doi + value: "10.5281/zenodo.22138229" + description: "Version-specific archival DOI for release v2.1.0" diff --git a/CONTRIBUTING.md b/CONTRIBUTING.md index b0a1374..79c84f3 100644 --- a/CONTRIBUTING.md +++ b/CONTRIBUTING.md @@ -4,4 +4,4 @@ This repository is an archival research companion. Please use an issue for repro Do not submit participant-level clinical data, dates linked to individuals, identifiers, ethics documents, credentials, unpublished institutional files, or third-party raw data through issues or pull requests. -Code contributions should preserve biological-unit handling, frozen module definitions, thresholds, and random seeds unless the change is explicitly labeled as a sensitivity analysis. Run the release validation workflow supplied in the Zenodo archive before proposing a change. +Code contributions should preserve biological-unit handling, frozen module definitions, thresholds, and random seeds unless the change is explicitly labeled as a sensitivity analysis. Run `python scripts/validate_release.py` before proposing a change. diff --git a/FILE_MANIFEST.txt b/FILE_MANIFEST.txt new file mode 100644 index 0000000..43920e1 --- /dev/null +++ b/FILE_MANIFEST.txt @@ -0,0 +1,260 @@ +bytes path +131 .gitignore +1495 .zenodo.json +2093 CHANGELOG.md +1313 CITATION.cff +678 CONTRIBUTING.md +495 LICENSE +1084 LICENSE_CODE_MIT.txt +540 LICENSE_DATA_CC-BY-4.0.txt +6994 README.md +2833 RELEASE_QA_REPORT.md +682 RELEASE_STATUS.md +10 VERSION +8606 code/atlas/m2_gse136103_build_h5ad.py +5505 code/atlas/m2_gse136103_cell_state_label_v1.py +4024 code/atlas/m2_gse136103_cell_state_pseudobulk_de.py +7488 code/atlas/m2_gse136103_scanpy_cluster_signature.py +15569 code/clinical/analyze_masld_flow_panel.py +48716 code/clinical/rebuild_final_clinical_visuals.py +16825 code/codex/UQ_CODEX_spatial_protein_validation.py +7509 code/figures/build_mechanism_circuit.py +9560 code/figures/rebuild_main_figure_plates.py +15569 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figures/supplementary/Supplementary_Figure_S30_UQ_Mapping_Sensitivity.pdf +289312 figures/supplementary/Supplementary_Figure_S30_UQ_Mapping_Sensitivity.png +33785 figures/supplementary/Supplementary_Figure_S30_UQ_Mapping_Sensitivity.svg +476124 figures/supplementary/Supplementary_Figure_S4.png +679968 figures/supplementary/Supplementary_Figure_S5.png +380288 figures/supplementary/Supplementary_Figure_S6.png +647572 figures/supplementary/Supplementary_Figure_S7.png +885990 figures/supplementary/Supplementary_Figure_S8.png +629651 figures/supplementary/Supplementary_Figure_S9.png +627 pyproject.toml +2374 results/S15_UQ_biopsy_mapping_sensitivity/UQ_BIOPSY_MAPPING_AUDIT.md +33160 results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.pdf +289312 results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.png +33785 results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.svg +1195 results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity_summary.json +488 results/S15_UQ_biopsy_mapping_sensitivity/UQ_geometry_reconstruction_summary.tsv +6861 results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_leave_one_array_out.tsv +5354 results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_scenario_stage_trends.tsv +32623 results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_scenario_topology.tsv +232537 results/S15_UQ_biopsy_mapping_sensitivity/UQ_spot_geometry_registration_audit.parquet +796134 results/S15_UQ_biopsy_mapping_sensitivity/geometry/UQ_Visium_component_geometry.png +1279 scripts/finalize_release.py +23256 scripts/validate_release.py +93697 uv.lock diff --git a/LICENSE_CODE_MIT.txt b/LICENSE_CODE_MIT.txt index 61d7d93..d27f775 100644 --- a/LICENSE_CODE_MIT.txt +++ b/LICENSE_CODE_MIT.txt @@ -19,3 +19,4 @@ AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE. + diff --git a/LICENSE_DATA_CC-BY-4.0.txt b/LICENSE_DATA_CC-BY-4.0.txt index b33ee9a..cb5669a 100644 --- a/LICENSE_DATA_CC-BY-4.0.txt +++ b/LICENSE_DATA_CC-BY-4.0.txt @@ -5,3 +5,4 @@ You may share and adapt this material for any purpose, provided that appropriate License text: https://creativecommons.org/licenses/by/4.0/legalcode This license does not replace the terms governing third-party public source datasets. Users must cite and comply with each source repository and study. + diff --git a/README.md b/README.md index 09fc1de..abd1ac0 100644 --- a/README.md +++ b/README.md @@ -1,50 +1,100 @@ -# PathoNiche Resolver-Window +# PathoNiche liver-fibrosis spatial retention atlas -[![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.21388386.svg)](https://doi.org/10.5281/zenodo.21388386) +Source data, derived results, code snapshots, audit records, and revised figures for the manuscript **“Stellate-cell retention progressively occupies liver scar and constricts repair interfaces.”** -Analysis-code snapshots, non-identifying aggregate clinical results, public-data-derived molecular and spatial results, and publication figures for the manuscript **“A resolver-window imbalance links stellate-cell scar occupation to liver fibrosis regression resistance.”** +> Release status: `v2.1.0`, a validated reproducibility release with clean-environment reconstruction. The repository is ; the version-specific archival DOI is . -Stable release: **v1.1.0** -Repository: -Archived release: +![Progressive HSC scar occupation](figures/main/Figure_5_Progressive_Retention_Domain_Occupation.png) -## Scientific scope +## Findings supported by this release -The repository supports five principal findings: +1. HSC-retention coupling to the human scar field strengthens across fibrosis stages. +2. Retention-dominant regions enlarge and coalesce while interfaces with endothelial and macrophage repair programs contract. +3. Geometry-only reconstruction and six mapping stress tests preserve retention-domain expansion and repair-interface compression; both effects also survive every leave-one-array-out analysis. +4. Replicated mouse withdrawal data show incomplete return toward the untreated state. +5. A static two-component Gaussian-mixture model describes the human spatial distribution and has a stable equal-posterior boundary. The analysis does not estimate a physical potential, dynamical flow field, or hysteresis parameter. +6. An asymmetric, order-aware LINCS score nominates forward and reverse role assignments for a factorial experiment. It does not measure an observed treatment-order effect or clinical efficacy. +7. The evidence-coded mechanism circuit separates literature-established links, project-supported associations, and candidate edges that require direct perturbational testing. -1. HSC-retention coupling to the scar field strengthens across human fibrosis stages. -2. Retention-dominant regions enlarge and coalesce into a dominant territory. -3. Interfaces between HSC-retention-dominant scar and endothelial/macrophage resolver-associated programs contract. -4. Injury withdrawal follows an incomplete return trajectory in resolver–retention state space. -5. The model generates an equal-exposure, order-dependent intervention hypothesis for prospective testing. +The release includes aggregate results from an 8,142-patient index cohort and a 772-patient longitudinal elastography cohort. Participant-level institutional records are not distributed. -The clinical component contains only non-identifying aggregate tables from an 8,142-patient index cohort and a 772-patient longitudinal elastography cohort. No participant-level clinical record is distributed. +## Quick validation -## Archived release +```bash +python3 -m venv .venv +source .venv/bin/activate +python -m pip install -r environment/requirements.txt +python scripts/validate_release.py +``` -The full versioned release, including analysis-code snapshots, derived aggregate outputs, documentation, validation reports, and publication figures, is archived on Zenodo: +To rebuild the four reviewer-facing replacement panels from included derived tables: -> Ying H, Zhang Z, Qiao C, Dong C, Yu H-w. *PathoNiche Resolver-Window: Analysis Code and Derived Data for Liver Fibrosis Regression Resistance*. Version 1.1.0. Zenodo; 2026. https://doi.org/10.5281/zenodo.21388386 +```bash +python code/reviewer_revision/rebuild_high_risk_panels.py +``` -The GitHub repository provides the public development and issue-tracking location. The Zenodo record is the immutable archival citation for version 1.1.0. +To rebuild the evidence-coded mechanism panel and the editable main SVG plates: + +```bash +python code/figures/build_mechanism_circuit.py +python code/figures/rebuild_main_figure_plates.py +``` + +## Repository map + +- `data/clinical_aggregate/`: non-identifying cohort counts, effect estimates, and validation metrics. +- `data/flow_aggregate/`: aggregate fatty-liver lymphocyte-panel summaries. +- `data/UQ_resolver_source_inputs/`: public UQ MASLD spatial module and coupling results. +- `data/UQ_spatial_derived/`: derived spatial, Gaussian-mixture, mouse, topology, and perturbational results. +- `data/UQ_spatial_mapping_derived/`: geometry-only Visium component assignments and summaries. +- `data/LINCS_derived/`: name-collapsed LINCS compound summaries. +- `data/mechanism_summary/`: edge-level mechanism evidence, phase tests, topology summaries, and order-score sensitivity. +- `data/mouse_pseudobulk_derived/`: public-data pseudobulk inputs and trajectory summaries. +- `data/figure_reconstruction/`: compact inputs for the corrected reviewer-facing panels. +- `code/public_mechanism/`: frozen public-data analysis scripts. +- `code/governed_clinical_transparency/`: institutional workflow snapshots; patient-level inputs are withheld. +- `code/reviewer_revision/`: self-contained high-risk-panel reconstruction. +- `code/figures/`: mechanism-circuit construction and editable main-figure composition. +- `figures/main/`: seven revised composite figures in PNG and PDF; Figures 1, 2, 5, and 7 also include editable SVG. +- `figures/source_panels/`: editable source panels used to compose Figure 7. +- `figures/reviewer_revision/`: editable SVG/PDF/PNG replacement panels and their source manifest. +- `figures/supplementary/`: Supplementary Figures S1-S30, including the geometry-only mapping sensitivity plate. +- `docs/methods_audit/`: data-structure, chronology, UQ reconstruction, drug-score, and panel-statistics audits. +- `docs/PANEL_PROVENANCE.tsv`: panel-level dataset, unit, sample size, method, script, output, and inference boundary. + +## Analysis chronology + +The final four-part analytical framework was written after several core analyses had been completed. It is therefore reported as a final organizational framework, not as prospective preregistration. The dated evidence is provided in `docs/methods_audit/machine_readable/Analysis_Timeline.tsv` and `Prespecification_and_Analysis_Timeline.docx`. + +UQ biopsy geometry and registration were completed before the retained-HSC, repair, and ECM score outputs in the archived run. The archive does not document strict analyst blinding to all biological information. An independent coordinate-only component reconstruction and mapping sensitivity analysis are provided in `docs/methods_audit/UQ_BIOPSY_RECONSTRUCTION_PROVENANCE.md` and `results/S15_UQ_biopsy_mapping_sensitivity/`. ## Reproducibility levels | Level | Contents | Publicly runnable | |---|---|---| -| A | Release validation and numerical-anchor audit | Yes, from the archived release | -| B | Derived UQ, mouse, LINCS, and aggregate clinical result inspection | Yes, from included files | -| C | Full public molecular/spatial reconstruction | Yes, after obtaining the public raw data listed in the archive | -| D | Patient-level clinical and flow analysis | No; requires institutional approval and governed source data | +| A | Release validation, file-integrity checks, and numerical-anchor audit | Yes | +| B | Reviewer-facing replacement panels from included derived inputs | Yes | +| C | Derived UQ, mouse, LINCS, and aggregate clinical result inspection | Yes | +| D | Full public molecular or spatial reconstruction | Yes, after obtaining raw public data listed in `docs/RAW_DATA_ACCESSIONS.md` | +| E | Patient-level clinical and flow analysis | No; institutional approval and governed source data are required | + +## Statistical units + +- Institutional analyses use the patient as the inferential unit. +- GSE295293 uses nine mice, three per group, with animal-level pseudobulk. +- GSE305331 contains seven condition libraries, each pooled from three mice; its 543,639 nuclei are technical observations and phase comparisons are descriptive. +- UQ Visium models aggregate 33 biopsy fragments to 32 patient clusters for stage-level inference; spatial blocks support within-section fitting. +- UQ CODEX contains one section at each displayed stage and is descriptive. +- LINCS signatures and compound pairs support computational ranking only. ## Data governance -Excluded material includes patient-level records, dates linked to individuals, direct or transformed clinical identifiers, linkage keys, the one-record flow–elastography linkage, ethics documents, author contact files, server credentials, raw public sequencing/imaging archives, LINCS Level 5 matrices, model weights, and manuscript drafts. +Excluded material includes participant-level records, direct or hashed clinical identifiers, linkage keys, ethics documents, author contact files, credentials, raw public sequencing or imaging archives, LINCS Level 5 matrices, and model weights. See `docs/PRIVACY_AND_GOVERNANCE.md`. -## Licenses +## Licenses and citation - Original analysis code: MIT License. -- Author-owned documentation, figures, and derived tabular outputs: Creative Commons Attribution 4.0 International. -- Third-party source datasets remain governed by their original terms and citation requirements. +- Author-owned documentation, figures, and derived tabular outputs: CC BY 4.0. +- Third-party source datasets remain governed by their original terms. -Machine-readable citation metadata are provided in `CITATION.cff` and `CITATION.bib`. +Please cite version `v2.1.0` using and cite the associated manuscript. Machine-readable metadata are provided in `CITATION.cff`. diff --git a/RELEASE_QA_REPORT.md b/RELEASE_QA_REPORT.md new file mode 100644 index 0000000..cb75fce --- /dev/null +++ b/RELEASE_QA_REPORT.md @@ -0,0 +1,46 @@ +# Release QA report + +## Scope + +Release `v2.1.0` contains privacy-screened aggregate institutional outputs, public-data-derived results, exact analytical audits, environment locks, executable workflows, and publication figures. Manuscript drafts, graphical-abstract concepts, private author or ethics material, participant-level clinical data, linkage files, credentials, and large public raw datasets are excluded. + +## Structural validation + +- 259 release files are covered by deterministic path, size, and SHA-256 manifests. +- All machine-readable TSV, CSV, JSON, and Parquet assets pass parsing and table-width checks. +- All Python scripts pass compilation and all R scripts pass parsing checks. +- Seven main figures are present in PNG and PDF; Figures 1, 2, 5, and 7 also include editable SVG plates. +- Supplementary Figures S1-S30 are present, including the UQ biopsy-mapping sensitivity plate. +- No cache or Finder residue is present. +- No release file exceeds the GitHub 100 MB limit. + +## Privacy and security validation + +- No participant-level clinical or flow table is present. +- No direct or transformed clinical identifier column was detected in proprietary aggregate tables. +- No email address, SSH endpoint, password, proxy subscription, private key, or credential string was detected in released content. +- No ethics PDF, author-private file, linkage table, hashing salt, manuscript DOCX, raw sequencing archive, LINCS Level 5 matrix, or model weight is present. +- Governed clinical scripts contain workflow definitions only; controlled inputs and secret values are absent. + +## Numerical reconciliation + +- Adult index cohort: 8,142. +- Longitudinal cohort: 772. +- UQ spatial analysis: 13,585 spots, 33 biopsy fragments, 32 patient clusters, and 589 spatial blocks. +- Coordinate-only reconstruction: 43 components, 13,539 direct assignments, and 46 nearest-component rescues. +- Largest retention-domain stage slope: +0.0960391. +- Resolver-retention interface stage slope: -0.0287332. +- Scenario sensitivity: both directions retained in 12/12 scenario-by-metric tests and 16/16 leave-one-array-out tests. +- One- versus two-component BIC gain: 141.0121859. +- Mouse withdrawal residual distance: 0.6983693. +- Order-aware forward and reverse scores: 0.8923123 and 0.5041989. +- Mechanism circuit: 14 literature-established, eight project-supported, and two candidate edges. + +The working release and a separate clean copy each completed with `PASS: 46 checks passed; 0 failed` after reconstruction was enabled. + +## Remaining publication holds + +- Complete all-author review and governance confirmation. +- Replace repository and DOI placeholders in `CITATION.cff` and manuscript availability statements. +- Remove the `rc1` suffix when the release is frozen. +- Regenerate manifests and the archive after any final metadata change. diff --git a/RELEASE_STATUS.md b/RELEASE_STATUS.md new file mode 100644 index 0000000..95fa1c5 --- /dev/null +++ b/RELEASE_STATUS.md @@ -0,0 +1,10 @@ +# Release status + +`v2.1.0` is the validated reproducibility release prepared for GitHub and Zenodo. The working tree and an independent clean copy each pass the complete release validator with reconstruction enabled. Its version-specific archival DOI is `10.5281/zenodo.22138229`. + +Merge to the public `main` branch remains blocked until all of the following are complete: + +1. The reserved Zenodo record is published and opened from a logged-out browser session. +2. Authors approve the aggregate clinical release and the manuscript has final ethics, funding, conflicts, and author-contribution text. + +Participant-level institutional and linkage data are excluded from this release. diff --git a/SHA256SUMS.txt b/SHA256SUMS.txt new file mode 100644 index 0000000..451fc1b --- /dev/null +++ b/SHA256SUMS.txt @@ -0,0 +1,259 @@ +d3b40063e1c15b59bc716f956ff97963dde5251081a642913db8a33d780641b1 .gitignore +cacfd7e2470bf1821db72a14871d70827c8f5240ca4211707e8c3e393189f282 .zenodo.json +10db427474c31fda630ebc74a694ccb27d454d60597e32cdb8f3047c9d9d9c52 CHANGELOG.md +07cb7641211d02e9c0a498d7ae57a931603bf463016b6090b03539691fd92822 CITATION.cff +5520b42820fc4ed70bc3ddea937a7a74dd45e4df07aec05a50d1311eb25efe91 CONTRIBUTING.md +cce5a9fbfcd442f933691d92232cb15f846d3255a915ec088e87145a2998e1e9 LICENSE +e5f301b0bf79d8fcd0a35d6f2dd0c8d3bbc894fdf0bfdf57e37b36c01045dd0b LICENSE_CODE_MIT.txt +c71abd554e311783b9f546987691893f142e5d4d3abae04df0ef0d775bcbab24 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results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_scenario_topology.tsv +0219c315a9a3d2c126b5f977b9bb860d55dd2bb888dde6fa844e8b357c0c5554 results/S15_UQ_biopsy_mapping_sensitivity/UQ_spot_geometry_registration_audit.parquet +2f1ab7ac1fc889edd509c3c085052d217f8978270bb439a0d073f8759b7aea55 results/S15_UQ_biopsy_mapping_sensitivity/geometry/UQ_Visium_component_geometry.png +a455946f40111c73fdb0954e69d7635ac8603fe04825b527c184a2460542273a scripts/finalize_release.py +524f63a35b0e1d239db6785af7e636601d33130a75182c26914d46645ce99f20 scripts/validate_release.py +e9c2111b7a242b71aff1b9f5071fb6a1e487c1242074a22887065adf65aa6e27 uv.lock diff --git a/VERSION b/VERSION index 9084fa2..85e0e21 100644 --- a/VERSION +++ b/VERSION @@ -1 +1 @@ -1.1.0 +2.1.0-rc1 diff --git a/code/atlas/m2_gse136103_build_h5ad.py b/code/atlas/m2_gse136103_build_h5ad.py new file mode 100644 index 0000000..ab10fff --- /dev/null +++ b/code/atlas/m2_gse136103_build_h5ad.py @@ -0,0 +1,187 @@ +import argparse +from pathlib import Path +import gzip, re, csv, json, time +import numpy as np +import pandas as pd +from scipy.io import mmread +from scipy import sparse +import anndata as ad + +REPO_ROOT = Path(__file__).resolve().parents[2] +parser = argparse.ArgumentParser(description=__doc__) +parser.add_argument('--raw-dir', type=Path, default=REPO_ROOT/'data/raw_external/GSE136103') +parser.add_argument('--output-dir', type=Path, default=REPO_ROOT/'results/GSE136103_atlas') +args = parser.parse_args() +RAW = args.raw_dir +OUT = args.output_dir +OUT.mkdir(parents=True, exist_ok=True) + +def parse_prefix(prefix: str): + parts = prefix.split('_') + gsm = parts[0] + rest = parts[1:] + meta = {'gsm': gsm, 'sample_prefix': prefix, 'dataset': 'GSE136103'} + if len(rest) >= 2 and re.match(r'^(healthy|cirrhotic)\d+$', rest[0]): + donor = rest[0] + disease = 'healthy' if donor.startswith('healthy') else 'cirrhotic' + meta.update({ + 'analysis_class': 'human_liver', + 'species': 'human', + 'tissue': 'liver', + 'disease': disease, + 'donor': donor, + 'donor_num': re.sub(r'^(healthy|cirrhotic)', '', donor), + 'sort_fraction': '_'.join(rest[1:]), + 'include_m2_primary': True, + }) + elif len(rest) == 1 and re.match(r'^blood\d+$', rest[0]): + meta.update({ + 'analysis_class': 'human_blood_reference', + 'species': 'human', + 'tissue': 'blood', + 'disease': 'reference_blood', + 'donor': rest[0], + 'donor_num': re.sub(r'^blood', '', rest[0]), + 'sort_fraction': 'unfractionated', + 'include_m2_primary': False, + }) + elif len(rest) >= 2 and rest[0] == 'mouse': + meta.update({ + 'analysis_class': 'mouse_liver_reference', + 'species': 'mouse', + 'tissue': 'liver', + 'disease': 'mouse_' + '_'.join(rest[1:]), + 'donor': 'mouse_' + '_'.join(rest[1:]), + 'donor_num': '', + 'sort_fraction': 'unspecified', + 'include_m2_primary': False, + }) + else: + meta.update({ + 'analysis_class': 'unknown', 'species': 'unknown', 'tissue': 'unknown', + 'disease': 'unknown', 'donor': '_'.join(rest), 'donor_num': '', + 'sort_fraction': 'unknown', 'include_m2_primary': False, + }) + return meta + +def count_lines_gz(path: Path): + n = 0 + with gzip.open(path, 'rt', encoding='utf-8', errors='replace') as fh: + for _ in fh: + n += 1 + return n + +triplets = {} +for f in RAW.glob('*.gz'): + name = f.name + for kind, suffix in [('barcodes','_barcodes.tsv.gz'), ('genes','_genes.tsv.gz'), ('matrix','_matrix.mtx.gz')]: + if name.endswith(suffix): + prefix = name[:-len(suffix)] + triplets.setdefault(prefix, {})[kind] = f + break + +rows = [] +for prefix, d in sorted(triplets.items()): + meta = parse_prefix(prefix) + missing = sorted(set(['barcodes','genes','matrix']) - set(d)) + n_b = count_lines_gz(d['barcodes']) if 'barcodes' in d else None + n_g = count_lines_gz(d['genes']) if 'genes' in d else None + m_rows = m_cols = m_nnz = None + if 'matrix' in d: + with gzip.open(d['matrix'], 'rt', encoding='utf-8', errors='replace') as fh: + for line in fh: + if line.startswith('%'): + continue + parts = line.strip().split() + if len(parts) >= 3: + m_rows, m_cols, m_nnz = map(int, parts[:3]); break + row = {**meta, + 'barcodes_file': d.get('barcodes', Path('')).name, + 'genes_file': d.get('genes', Path('')).name, + 'matrix_file': d.get('matrix', Path('')).name, + 'missing_files': ','.join(missing), + 'n_barcodes': n_b, 'n_genes_file_lines': n_g, + 'matrix_n_genes': m_rows, 'matrix_n_cells': m_cols, 'matrix_nnz': m_nnz, + 'genes_match': bool(n_g == m_rows) if n_g is not None and m_rows is not None else False, + 'barcodes_match': bool(n_b == m_cols) if n_b is not None and m_cols is not None else False, + } + rows.append(row) + +pd.DataFrame(rows).to_csv(OUT/'GSE136103_raw_sample_audit_all26.tsv', sep='\t', index=False) +summary = { + 'n_samples_total': len(rows), + 'n_primary_human_liver_samples': sum(r['include_m2_primary'] for r in rows), + 'n_human_blood_reference_samples': sum(r['analysis_class']=='human_blood_reference' for r in rows), + 'n_mouse_reference_samples': sum(r['analysis_class']=='mouse_liver_reference' for r in rows), + 'primary_cells_by_barcodes': sum(int(r['n_barcodes']) for r in rows if r['include_m2_primary']), + 'all_triplets_complete': all(not r['missing_files'] for r in rows), + 'all_dimensions_match': all(r['genes_match'] and r['barcodes_match'] for r in rows), +} +(OUT/'GSE136103_raw_sample_audit_all26.summary.json').write_text(json.dumps(summary, indent=2, sort_keys=True)+'\n') +print('AUDIT_SUMMARY', json.dumps(summary, sort_keys=True)) + +primary = [r for r in rows if r['include_m2_primary']] +adatas = [] +for i, r in enumerate(primary, 1): + t0 = time.time() + prefix = r['sample_prefix'] + print(f'READ_SAMPLE {i}/{len(primary)} {prefix}', flush=True) + genes_path = RAW / r['genes_file'] + barcodes_path = RAW / r['barcodes_file'] + matrix_path = RAW / r['matrix_file'] + genes = pd.read_csv(genes_path, sep='\t', header=None, names=['gene_id','gene_symbol']) + barcodes = pd.read_csv(barcodes_path, sep='\t', header=None, names=['barcode']) + X = mmread(str(matrix_path)).tocsr().T.tocsr() + obs = pd.DataFrame({ + 'barcode': barcodes['barcode'].astype(str).values, + 'sample_prefix': prefix, + 'gsm': r['gsm'], + 'donor': r['donor'], + 'donor_num': r['donor_num'], + 'disease': r['disease'], + 'sort_fraction': r['sort_fraction'], + 'dataset': 'GSE136103', + }) + obs.index = [f'{prefix}:{bc}' for bc in obs['barcode']] + var = genes.copy() + var.index = var['gene_id'].astype(str) + a = ad.AnnData(X=X, obs=obs, var=var) + adatas.append(a) + print(f'DONE_SAMPLE {prefix} cells={a.n_obs} genes={a.n_vars} nnz={a.X.nnz} sec={time.time()-t0:.1f}', flush=True) + +print('CONCAT_START', flush=True) +adata = ad.concat(adatas, join='inner', label='sample_prefix_from_concat', keys=[a.obs['sample_prefix'][0] for a in adatas], merge='same') +adata.var['mt'] = adata.var['gene_symbol'].astype(str).str.upper().str.startswith('MT-').values +X = adata.X.tocsr() if sparse.issparse(adata.X) else sparse.csr_matrix(adata.X) +adata.obs['n_counts'] = np.asarray(X.sum(axis=1)).ravel() +adata.obs['n_genes_by_counts'] = np.asarray((X > 0).sum(axis=1)).ravel() +mt_mask = adata.var['mt'].values +if mt_mask.any(): + mt_counts = np.asarray(X[:, mt_mask].sum(axis=1)).ravel() + adata.obs['pct_counts_mt'] = np.divide(mt_counts, adata.obs['n_counts'].values, out=np.zeros(adata.n_obs), where=adata.obs['n_counts'].values>0) * 100 +else: + adata.obs['pct_counts_mt'] = 0.0 +adata.uns['build_note'] = 'GSE136103 human liver primary samples only; blood and mouse reference samples excluded from this h5ad and retained in audit table.' +adata.uns['raw_audit_summary'] = summary +raw_path = OUT/'GSE136103_human_liver_raw_counts_qc.h5ad' +adata.write_h5ad(raw_path, compression='gzip') +qc = adata.obs.groupby(['disease','sort_fraction'], observed=True).agg( + n_cells=('n_counts','size'), + median_counts=('n_counts','median'), + median_genes=('n_genes_by_counts','median'), + median_pct_mt=('pct_counts_mt','median'), +).reset_index() +qc.to_csv(OUT/'GSE136103_human_liver_qc_by_group.tsv', sep='\t', index=False) +filter_mask = (adata.obs['n_genes_by_counts'] >= 200) & (adata.obs['n_genes_by_counts'] <= 6000) & (adata.obs['pct_counts_mt'] <= 25) +adata_f = adata[filter_mask].copy() +adata_f.uns['filter_rule'] = 'n_genes_by_counts>=200, <=6000, pct_counts_mt<=25; thresholds are first-pass for downstream review.' +filtered_path = OUT/'GSE136103_human_liver_filtered_qc_v1.h5ad' +adata_f.write_h5ad(filtered_path, compression='gzip') +filter_summary = { + 'raw_cells': int(adata.n_obs), 'raw_genes': int(adata.n_vars), + 'filtered_cells': int(adata_f.n_obs), 'filtered_genes': int(adata_f.n_vars), + 'retained_fraction': float(adata_f.n_obs / adata.n_obs), + 'output_raw_h5ad': str(raw_path), 'output_filtered_h5ad': str(filtered_path), +} +(OUT/'GSE136103_human_liver_filter_summary.json').write_text(json.dumps(filter_summary, indent=2, sort_keys=True)+'\n') +print('FILTER_SUMMARY', json.dumps(filter_summary, sort_keys=True)) diff --git a/code/atlas/m2_gse136103_cell_state_label_v1.py b/code/atlas/m2_gse136103_cell_state_label_v1.py new file mode 100644 index 0000000..8817d93 --- /dev/null +++ b/code/atlas/m2_gse136103_cell_state_label_v1.py @@ -0,0 +1,91 @@ +import argparse +from pathlib import Path +import json +import numpy as np +import pandas as pd +from scipy import sparse +import scanpy as sc + +REPO_ROOT=Path(__file__).resolve().parents[2] +parser=argparse.ArgumentParser(description=__doc__) +parser.add_argument('--input-h5ad',type=Path,default=REPO_ROOT/'results/GSE136103_atlas/GSE136103_human_liver_scanpy_clustered_v1.h5ad') +parser.add_argument('--output-dir',type=Path,default=REPO_ROOT/'results/GSE136103_atlas') +args=parser.parse_args() +OUT=args.output_dir +ADATA=args.input_h5ad +OUT.mkdir(parents=True,exist_ok=True) +adata=sc.read_h5ad(ADATA) +marker_sets={ + 'Hepatocyte':['ALB','APOA1','APOB','TTR','TF','CYP3A4','CYP2E1','HP'], + 'Cholangiocyte':['KRT19','KRT7','EPCAM','SOX9','MUC1','CFTR'], + 'Endothelial':['PECAM1','VWF','KDR','FLT1','ENG','RAMP2','PLVAP','CLEC4G','STAB2'], + 'Lymphatic_endothelial':['PROX1','PDPN','LYVE1','CCL21','FLT4'], + 'HSC_Myofibroblast':['COL1A1','COL1A2','COL3A1','COL6A3','DCN','LUM','RGS5','ACTA2','TAGLN','PDGFRB','COL15A1'], + 'Macrophage_Kupffer':['CD68','MARCO','C1QA','C1QB','C1QC','LST1','FCGR3A','TYROBP','TREM2','SPP1'], + 'Monocyte_inflammatory':['S100A8','S100A9','FCN1','LYZ','VCAN','LST1','IL1B'], + 'T_NK':['CD3D','CD3E','TRAC','NKG7','GNLY','PRF1','GZMB','IL7R'], + 'B_cell':['MS4A1','CD79A','CD79B','BANK1','CD74'], + 'Plasma_cell':['MZB1','JCHAIN','XBP1','IGHG1','IGKC','SDC1'], + 'Mast_cell':['TPSAB1','TPSB2','CPA3','KIT','MS4A2'], + 'Cycling':['MKI67','TOP2A','STMN1','HMGB2','UBE2C'], + 'Erythroid':['HBB','HBA1','HBA2','ALAS2'], +} +# Gene symbol to var index map; duplicates collapsed by first occurrence. +symbols=adata.var['gene_symbol'].astype(str) if 'gene_symbol' in adata.var.columns else pd.Series(adata.var_names,index=adata.var_names) +sym_to_ids={} +for gid,sym in symbols.items(): + sym_to_ids.setdefault(sym.upper(), gid) +X=adata.X.tocsr() if sparse.issparse(adata.X) else sparse.csr_matrix(adata.X) +clusters=sorted(adata.obs['leiden_r08'].astype(str).unique(), key=lambda x:int(x) if x.isdigit() else x) +rows=[] +for cl in clusters: + mask=(adata.obs['leiden_r08'].astype(str).values==cl) + for label,markers in marker_sets.items(): + ids=[sym_to_ids[m.upper()] for m in markers if m.upper() in sym_to_ids] + if ids: + idx=[adata.var_names.get_loc(i) for i in ids] + score=float(np.asarray(X[mask][:,idx].mean(axis=1)).ravel().mean()) + frac=float(np.asarray((X[mask][:,idx]>0).mean(axis=0)).ravel().mean()) + else: + score=np.nan; frac=np.nan + rows.append({'cluster':cl,'marker_label':label,'n_markers_present':len(ids),'mean_logexpr_score':score,'mean_marker_fraction':frac,'markers_present':';'.join([symbols.loc[i] for i in ids])}) +scores=pd.DataFrame(rows) +scores.to_csv(OUT/'GSE136103_cluster_marker_panel_scores_v1.tsv',sep='\t',index=False) +# Assign top label by mean score; require at least two markers except rare/erythroid panels where one strong marker can dominate. +assign=[] +comp=pd.read_csv(OUT/'GSE136103_leiden_r08_cluster_summary.tsv',sep='\t') +if 'leiden_r08' in comp.columns: + comp['leiden_r08']=comp['leiden_r08'].astype(str) +if 'cluster' in comp.columns: + comp['cluster']=comp['cluster'].astype(str) +for cl in clusters: + s=scores[(scores.cluster==cl) & (scores.n_markers_present>0)].sort_values(['mean_logexpr_score','mean_marker_fraction'],ascending=False) + top=s.iloc[0] + second=s.iloc[1] if len(s)>1 else top + assigned=top['marker_label'] + confidence='medium' + if top['mean_logexpr_score']>=1.0 and (top['mean_logexpr_score']-second['mean_logexpr_score'])>=0.20: + confidence='high' + elif top['mean_logexpr_score']<0.35: + confidence='low' + assigned='Unresolved_'+str(assigned) + row={'cluster':cl,'cell_state_v1':assigned,'label_confidence':confidence,'top_score':top['mean_logexpr_score'],'second_label':second['marker_label'],'second_score':second['mean_logexpr_score']} + assign.append(row) +assign=pd.DataFrame(assign) +if 'leiden_r08' in comp.columns: + assign=assign.merge(comp, how='left', left_on='cluster', right_on='leiden_r08').drop(columns=['leiden_r08']) +else: + assign=assign.merge(comp, how='left', on='cluster') +assign['fibrotic_niche_candidate']=(assign['pct_cirrhotic'].fillna(0)>=60) & (assign['cell_state_v1'].str.contains('HSC|Macrophage|Endothelial|Cholangiocyte|Lymphatic',regex=True)) +assign.to_csv(OUT/'cell_state_labels.tsv',sep='\t',index=False) +assign[assign['fibrotic_niche_candidate']].to_csv(OUT/'fibrotic_niche_clusters_v1.tsv',sep='\t',index=False) +label_map=assign.set_index('cluster')['cell_state_v1'].to_dict() +conf_map=assign.set_index('cluster')['label_confidence'].to_dict() +adata.obs['cell_state_v1']=adata.obs['leiden_r08'].astype(str).map(label_map).astype('category') +adata.obs['cell_state_v1_confidence']=adata.obs['leiden_r08'].astype(str).map(conf_map).astype('category') +adata.uns['cell_state_label_note']='Rule-based marker panel v1 from canonical liver/immune markers; inspect before manuscript-grade cell type claims.' +adata.write_h5ad(OUT/'GSE136103_human_liver_cell_state_labels_v1.h5ad',compression='gzip') +summary={'clusters':len(assign),'fibrotic_niche_candidate_clusters':int(assign['fibrotic_niche_candidate'].sum()),'cell_states':sorted(assign['cell_state_v1'].unique().tolist())} +(OUT/'cell_state_labels.summary.json').write_text(json.dumps(summary,indent=2,sort_keys=True)+'\n') +print(assign.sort_values('cluster').to_string(index=False)) +print('SUMMARY', json.dumps(summary, sort_keys=True)) diff --git a/code/atlas/m2_gse136103_cell_state_pseudobulk_de.py b/code/atlas/m2_gse136103_cell_state_pseudobulk_de.py new file mode 100644 index 0000000..249ee8e --- /dev/null +++ b/code/atlas/m2_gse136103_cell_state_pseudobulk_de.py @@ -0,0 +1,66 @@ +import argparse +from pathlib import Path +import json +import numpy as np +import pandas as pd +from scipy import sparse, stats +from statsmodels.stats.multitest import multipletests +import scanpy as sc + +REPO_ROOT=Path(__file__).resolve().parents[2] +parser=argparse.ArgumentParser(description=__doc__) +parser.add_argument('--input-h5ad',type=Path,default=REPO_ROOT/'results/GSE136103_atlas/GSE136103_human_liver_cell_state_labels_v1.h5ad') +parser.add_argument('--output-dir',type=Path,default=REPO_ROOT/'results/GSE136103_atlas') +args=parser.parse_args() +OUT=args.output_dir +OUT.mkdir(parents=True,exist_ok=True) +adata=sc.read_h5ad(args.input_h5ad) +X=adata.layers['counts'] if 'counts' in adata.layers else adata.X +X=X.tocsr() if sparse.issparse(X) else sparse.csr_matrix(X) +symbols=adata.var['gene_symbol'].astype(str).values if 'gene_symbol' in adata.var.columns else adata.var_names.astype(str).values +rows=[]; meta=[] +for state in sorted(adata.obs['cell_state_v1'].astype(str).unique()): + obs_s=adata.obs[adata.obs['cell_state_v1'].astype(str).values==state] + for donor in sorted(obs_s['donor'].astype(str).unique()): + idx=np.where((adata.obs['cell_state_v1'].astype(str).values==state) & (adata.obs['donor'].astype(str).values==donor))[0] + if len(idx)<20: + continue + summed=np.asarray(X[idx].sum(axis=0)).ravel() + rows.append(summed) + disease=adata.obs.iloc[idx[0]]['disease'] + meta.append({'cell_state_v1':state,'donor':donor,'disease':disease,'n_cells':len(idx),'library_size':float(summed.sum())}) +counts=np.vstack(rows) +meta=pd.DataFrame(meta) +lib=counts.sum(axis=1) +logcpm=np.log2((counts/lib[:,None])*1e6+1) +all_de=[]; sig_lines=[] +for state in sorted(meta['cell_state_v1'].unique()): + mask=(meta['cell_state_v1']==state).values + m=meta[mask].reset_index(drop=True) + mat=logcpm[mask] + cirr=(m['disease']=='cirrhotic').values + heal=(m['disease']=='healthy').values + if cirr.sum()<3 or heal.sum()<3: + continue + mean_c=mat[cirr].mean(axis=0); mean_h=mat[heal].mean(axis=0) + lfc=mean_c-mean_h + t,p=stats.ttest_ind(mat[cirr],mat[heal],axis=0,equal_var=False,nan_policy='omit') + p=np.where(np.isfinite(p),p,1.0) + fdr=multipletests(p,method='fdr_bh')[1] + df=pd.DataFrame({'cell_state_v1':state,'gene_id':adata.var_names.astype(str),'gene_symbol':symbols,'log2fc_cirrhotic_vs_healthy':lfc,'mean_logcpm_cirrhotic':mean_c,'mean_logcpm_healthy':mean_h,'t_stat':t,'p_value':p,'fdr_bh':fdr,'n_cirrhotic_donors':int(cirr.sum()),'n_healthy_donors':int(heal.sum()),'n_cirrhotic_cells':int(m.loc[cirr,'n_cells'].sum()),'n_healthy_cells':int(m.loc[heal,'n_cells'].sum())}) + df=df.sort_values(['fdr_bh','log2fc_cirrhotic_vs_healthy'],ascending=[True,False]) + all_de.append(df) + up=df[(df['log2fc_cirrhotic_vs_healthy']>0.25)&(df['mean_logcpm_cirrhotic']>1)].head(80) + genes=[g for g in up['gene_symbol'].astype(str).tolist() if g and g.lower()!='nan'] + if genes: + sig_lines.append(state.replace(' ','_')+'_CIRRHOTIC_UP\tGSE136103 cell-state donor-pseudobulk cirrhotic-up\t'+'\t'.join(genes)) +res=pd.concat(all_de,ignore_index=True) +res.to_csv(OUT/'GSE136103_cell_state_pseudobulk_cirrhotic_vs_healthy.tsv',sep='\t',index=False) +meta.to_csv(OUT/'GSE136103_cell_state_pseudobulk_meta.tsv',sep='\t',index=False) +(OUT/'GSE136103_cell_state_cirrhotic_up_signatures_v1.gmt').write_text('\n'.join(sig_lines)+'\n') +summary=res.groupby('cell_state_v1').agg(n_tested=('gene_id','size'),top_gene=('gene_symbol','first'),top_log2fc=('log2fc_cirrhotic_vs_healthy','first'),top_fdr=('fdr_bh','first')).reset_index() +summary.to_csv(OUT/'GSE136103_cell_state_pseudobulk_de_summary.tsv',sep='\t',index=False) +js={'cell_states_tested':int(summary.shape[0]),'pseudobulk_profiles':int(meta.shape[0]),'signature_lines':len(sig_lines)} +(OUT/'GSE136103_cell_state_pseudobulk_de.summary.json').write_text(json.dumps(js,indent=2,sort_keys=True)+'\n') +print(summary.to_string(index=False)) +print('SUMMARY', json.dumps(js, sort_keys=True)) diff --git a/code/atlas/m2_gse136103_scanpy_cluster_signature.py b/code/atlas/m2_gse136103_scanpy_cluster_signature.py new file mode 100644 index 0000000..60cd022 --- /dev/null +++ b/code/atlas/m2_gse136103_scanpy_cluster_signature.py @@ -0,0 +1,148 @@ +import argparse +from pathlib import Path +import json, time +import numpy as np +import pandas as pd +from scipy import sparse, stats +import scanpy as sc +import harmonypy as hm +from statsmodels.stats.multitest import multipletests + +REPO_ROOT = Path(__file__).resolve().parents[2] +parser = argparse.ArgumentParser(description=__doc__) +parser.add_argument('--input-h5ad', type=Path, default=REPO_ROOT/'results/GSE136103_atlas/GSE136103_human_liver_filtered_qc_v1.h5ad') +parser.add_argument('--output-dir', type=Path, default=REPO_ROOT/'results/GSE136103_atlas') +parser.add_argument('--threads', type=int, default=8) +args = parser.parse_args() +sc.settings.n_jobs = args.threads +OUT = args.output_dir +IN = args.input_h5ad +OUT.mkdir(parents=True, exist_ok=True) +print('READ', IN, flush=True) +t0 = time.time() +adata = sc.read_h5ad(IN) +print(f'LOADED cells={adata.n_obs} genes={adata.n_vars} sec={time.time()-t0:.1f}', flush=True) + +# Donor-level pseudobulk disease signature from raw counts before normalization. +print('PSEUDOBULK_START', flush=True) +Xraw = adata.X.tocsr() if sparse.issparse(adata.X) else sparse.csr_matrix(adata.X) +donors = adata.obs[['donor','disease']].drop_duplicates().sort_values(['disease','donor']) +rows = [] +labels = [] +for _, row in donors.iterrows(): + mask = (adata.obs['donor'].values == row['donor']) + s = np.asarray(Xraw[mask].sum(axis=0)).ravel() + rows.append(s) + labels.append((row['donor'], row['disease'], int(mask.sum()))) +counts = np.vstack(rows) +lib = counts.sum(axis=1) +logcpm = np.log2((counts / lib[:, None]) * 1e6 + 1) +disease_arr = np.array([x[1] for x in labels]) +cirr = disease_arr == 'cirrhotic' +healthy = disease_arr == 'healthy' +mean_c = logcpm[cirr].mean(axis=0) +mean_h = logcpm[healthy].mean(axis=0) +logfc = mean_c - mean_h +tstat, pval = stats.ttest_ind(logcpm[cirr], logcpm[healthy], axis=0, equal_var=False, nan_policy='omit') +pval = np.where(np.isfinite(pval), pval, 1.0) +fdr = multipletests(pval, method='fdr_bh')[1] +var = adata.var.copy() +gene_symbol = var['gene_symbol'].astype(str).values if 'gene_symbol' in var.columns else var.index.astype(str).values +sig = pd.DataFrame({ + 'gene_id': adata.var_names.astype(str), + 'gene_symbol': gene_symbol, + 'mean_logcpm_cirrhotic': mean_c, + 'mean_logcpm_healthy': mean_h, + 'log2fc_cirrhotic_vs_healthy': logfc, + 't_stat': tstat, + 'p_value': pval, + 'fdr_bh': fdr, +}) +sig = sig.sort_values(['fdr_bh','log2fc_cirrhotic_vs_healthy'], ascending=[True, False]) +sig.to_csv(OUT/'GSE136103_donor_pseudobulk_cirrhotic_vs_healthy.tsv', sep='\t', index=False) +up = sig[(sig['log2fc_cirrhotic_vs_healthy'] > 0.25) & (sig['mean_logcpm_cirrhotic'] > 1)].copy() +if len(up) < 50: + up = sig[sig['log2fc_cirrhotic_vs_healthy'] > 0].copy() +up = up.sort_values(['fdr_bh','log2fc_cirrhotic_vs_healthy'], ascending=[True, False]).head(150) +up.to_csv(OUT/'fibrotic_niche_signature_v1_genes.tsv', sep='\t', index=False) +genes_for_gmt = [g for g in up['gene_symbol'].astype(str).tolist() if g and g.lower() != 'nan'] +(OUT/'fibrotic_niche_signature_v1.gmt').write_text('FIBROTIC_NICHE_GSE136103_V1\tGSE136103 donor-pseudobulk cirrhotic-up human liver signature\t' + '\t'.join(genes_for_gmt) + '\n') +pb_meta = pd.DataFrame(labels, columns=['donor','disease','n_cells']) +pb_meta.to_csv(OUT/'GSE136103_donor_pseudobulk_meta.tsv', sep='\t', index=False) +print(f'PSEUDOBULK_DONE up_genes={len(up)} gmt_genes={len(genes_for_gmt)}', flush=True) + +# Standard single-cell embedding and clustering. +print('SCANPY_NORMALIZE', flush=True) +adata.layers['counts'] = Xraw.copy() +sc.pp.normalize_total(adata, target_sum=1e4) +sc.pp.log1p(adata) +adata.raw = adata +print('HVG', flush=True) +sc.pp.highly_variable_genes(adata, flavor='seurat_v3', n_top_genes=3000, batch_key='sample_prefix', layer='counts') +adata_hvg = adata[:, adata.var['highly_variable']].copy() +print(f'HVG_SELECTED {adata_hvg.n_vars}', flush=True) +sc.pp.scale(adata_hvg, max_value=10) +print('PCA', flush=True) +sc.tl.pca(adata_hvg, n_comps=50, svd_solver='arpack') +print('HARMONY', flush=True) +ho = hm.run_harmony(adata_hvg.obsm['X_pca'], adata_hvg.obs, ['sample_prefix'], max_iter_harmony=20) +Z = ho.Z_corr +if Z.shape[0] == adata_hvg.n_obs: + adata_hvg.obsm['X_pca_harmony'] = Z +elif Z.shape[1] == adata_hvg.n_obs: + adata_hvg.obsm['X_pca_harmony'] = Z.T +else: + raise ValueError(f'Harmony output shape {Z.shape} incompatible with n_obs={adata_hvg.n_obs}') +print(f'HARMONY_SHAPE {adata_hvg.obsm["X_pca_harmony"].shape}', flush=True) +print('NEIGHBORS_UMAP_LEIDEN', flush=True) +sc.pp.neighbors(adata_hvg, n_neighbors=20, n_pcs=40, use_rep='X_pca_harmony') +sc.tl.umap(adata_hvg, min_dist=0.35, spread=1.0) +sc.tl.leiden(adata_hvg, resolution=0.8, flavor='igraph', n_iterations=2, key_added='leiden_r08') +# Copy clustering and embeddings back into full object, keeping memory moderate. +adata.obs['leiden_r08'] = adata_hvg.obs['leiden_r08'].astype(str).values +adata.obsm['X_pca_harmony'] = adata_hvg.obsm['X_pca_harmony'] +adata.obsm['X_umap'] = adata_hvg.obsm['X_umap'] +adata.uns['neighbors'] = adata_hvg.uns['neighbors'] +adata.obsp['distances'] = adata_hvg.obsp['distances'] +adata.obsp['connectivities'] = adata_hvg.obsp['connectivities'] +adata.uns['leiden'] = adata_hvg.uns.get('leiden', {}) +adata.uns['m2_signature_note'] = 'fibrotic_niche_signature_v1.gmt from donor-level pseudobulk cirrhotic vs healthy, not yet cell-type refined.' +print('COMPOSITION', flush=True) +comp = adata.obs.groupby(['leiden_r08','disease','sort_fraction'], observed=True).size().reset_index(name='n_cells') +comp.to_csv(OUT/'GSE136103_leiden_r08_composition.tsv', sep='\t', index=False) +cluster_summary = adata.obs.groupby('leiden_r08', observed=True).agg( + n_cells=('disease','size'), + pct_cirrhotic=('disease', lambda x: float((x=='cirrhotic').mean()*100)), + n_donors=('donor', lambda x: int(pd.Series(x).nunique())), +).reset_index() +cluster_summary.to_csv(OUT/'GSE136103_leiden_r08_cluster_summary.tsv', sep='\t', index=False) +print('MARKERS', flush=True) +sc.tl.rank_genes_groups(adata, groupby='leiden_r08', method='wilcoxon', pts=True, n_genes=80) +marker_rows = [] +rg = adata.uns['rank_genes_groups'] +groups = rg['names'].dtype.names +symbol_map = adata.var['gene_symbol'].astype(str).to_dict() if 'gene_symbol' in adata.var.columns else {} +for g in groups: + names = rg['names'][g] + for rank, gene_id in enumerate(names, 1): + marker_rows.append({ + 'cluster': g, 'rank': rank, 'gene_id': gene_id, + 'gene_symbol': symbol_map.get(gene_id, gene_id), + 'score': float(rg['scores'][g][rank-1]), + 'logfoldchanges': float(rg['logfoldchanges'][g][rank-1]) if 'logfoldchanges' in rg else np.nan, + 'pvals_adj': float(rg['pvals_adj'][g][rank-1]) if 'pvals_adj' in rg else np.nan, + }) +pd.DataFrame(marker_rows).to_csv(OUT/'GSE136103_leiden_r08_markers_top80.tsv', sep='\t', index=False) +print('WRITE_H5AD', flush=True) +adata.write_h5ad(OUT/'GSE136103_human_liver_scanpy_clustered_v1.h5ad', compression='gzip') +summary = { + 'input': str(IN), + 'cells': int(adata.n_obs), + 'genes': int(adata.n_vars), + 'hvg': int(adata_hvg.n_vars), + 'clusters_leiden_r08': int(adata.obs['leiden_r08'].nunique()), + 'signature_genes': int(len(genes_for_gmt)), + 'elapsed_sec': round(time.time()-t0, 1), +} +(OUT/'GSE136103_scanpy_cluster_signature_summary.json').write_text(json.dumps(summary, indent=2, sort_keys=True)+'\n') +print('DONE', json.dumps(summary, sort_keys=True), flush=True) diff --git a/code/clinical/analyze_masld_flow_panel.py b/code/clinical/analyze_masld_flow_panel.py new file mode 100644 index 0000000..25c1b61 --- /dev/null +++ b/code/clinical/analyze_masld_flow_panel.py @@ -0,0 +1,319 @@ +#!/usr/bin/env python3 +"""Deidentify and analyze real-world lymphocyte panels from fatty-liver-coded encounters.""" + +from __future__ import annotations + +import argparse +import hashlib +import json +from pathlib import Path +import re + +import matplotlib.pyplot as plt +import matplotlib.dates as mdates +import numpy as np +import pandas as pd +import seaborn as sns +from sklearn.decomposition import PCA +from sklearn.preprocessing import StandardScaler +import statsmodels.api as sm + + +REPO_ROOT = Path(__file__).resolve().parents[2] +RAW = REPO_ROOT / "data/governed/flow_panel" +RESULTS = REPO_ROOT / "results/flow_panel" +FIGURES = RESULTS / "figures" +CLINICAL = REPO_ROOT / "data/governed/clinical/matched_90d.parquet" +SALT_PATH = REPO_ROOT / "data/governed/clinical_hash_salt.txt" + +MARKERS = ["CD16+CD56+", "CD3+", "CD3+CD4+", "CD3+CD8+", "CD3-CD19+", "CD4/CD8"] +DISPLAY = { + "CD16+CD56+": "NK", + "CD3+": "T", + "CD3+CD4+": "CD4 T", + "CD3+CD8+": "CD8 T", + "CD3-CD19+": "B", + "CD4/CD8": "CD4/CD8", +} +CONTEXT_ORDER = ["metabolic-dominant", "acute-inflammatory", "oncology/hematology"] +CONTEXT_COLORS = { + "metabolic-dominant": "#2A9D8F", + "acute-inflammatory": "#E2A33A", + "oncology/hematology": "#B4495B", +} + + +def digest(salt: str, namespace: str, value: object) -> str: + payload = f"{salt}|{namespace}|{str(value).strip()}".encode() + return hashlib.sha256(payload).hexdigest() + + +def bh(values: pd.Series) -> np.ndarray: + p = values.to_numpy(float) + order = np.argsort(p) + q = p[order] * len(p) / np.arange(1, len(p) + 1) + q = np.minimum.accumulate(q[::-1])[::-1] + result = np.empty_like(q) + result[order] = np.clip(q, 0, 1) + return result + + +def load_panel() -> pd.DataFrame: + salt = SALT_PATH.read_text().strip() + frames = [] + for path in sorted(RAW.glob("*.xlsx")): + local = pd.read_excel(path) + local["source_file"] = path.name + frames.append(local) + long = pd.concat(frames, ignore_index=True) + long["sex"] = long["性别"].map({"男": "M", "女": "F"}) + long["birth_date"] = pd.to_datetime(long["出生日期"], errors="coerce") + long["flow_timestamp"] = pd.to_datetime(long["审核时间"], errors="coerce") + key_plain = long.birth_date.dt.strftime("%Y-%m-%d") + "|" + long.sex + long["dob_sex_key_hash"] = key_plain.map(lambda value: digest(salt, "dob_sex", value)) + long["flow_subject_hash"] = long["身份证号"].astype(str).map(lambda value: digest(salt, "flow_subject", value)) + long["flow_event_hash"] = [ + digest(salt, "flow_event", f"{subject}|{timestamp}|{barcode}") + for subject, timestamp, barcode in zip(long.flow_subject_hash, long.flow_timestamp, long["条码号"]) + ] + index = [ + "flow_event_hash", "flow_subject_hash", "dob_sex_key_hash", "flow_timestamp", + "birth_date", "sex", "年龄", "诊断", "source_file", + ] + wide = long.pivot_table(index=index, columns="项目代码", values="测定结果", aggfunc="first").reset_index() + wide.columns.name = None + missing = [marker for marker in MARKERS if marker not in wide] + if missing: + raise ValueError(f"Missing flow markers: {missing}") + wide["age"] = pd.to_numeric(wide["年龄"].astype(str).str.extract(r"(\d+)")[0], errors="coerce") + diagnosis = wide["诊断"].fillna("") + oncology = diagnosis.str.contains(r"淋巴瘤|白血病|骨髓瘤|骨髓增生|恶性肿瘤|化学治疗|靶向治疗", regex=True) + infection = diagnosis.str.contains(r"感染|肺炎|发热|败血|脓毒|急性下呼吸道感染", regex=True) + wide["context"] = np.where( + oncology, + "oncology/hematology", + np.where(infection, "acute-inflammatory", "metabolic-dominant"), + ) + wide["diabetes"] = diagnosis.str.contains("糖尿病") + wide["hypertension"] = diagnosis.str.contains("高血压") + wide["viral_hepatitis"] = diagnosis.str.contains(r"乙型病毒性肝炎|丙型病毒性肝炎|病毒性肝炎", regex=True) + wide["liver_dysfunction"] = diagnosis.str.contains(r"肝功能不全|肝硬化|肝衰竭", regex=True) + total = wide["CD16+CD56+"] + wide["CD3+"] + wide["CD3-CD19+"] + wide["NK_fraction"] = wide["CD16+CD56+"] / total + wide["T_fraction"] = wide["CD3+"] / total + wide["B_fraction"] = wide["CD3-CD19+"] / total + wide["CD4_T_fraction"] = wide["CD3+CD4+"] / wide["CD3+"] + wide["CD8_T_fraction"] = wide["CD3+CD8+"] / wide["CD3+"] + wide["computed_CD4_CD8"] = wide["CD3+CD4+"] / wide["CD3+CD8+"] + wide["ratio_relative_error"] = (wide["computed_CD4_CD8"] - wide["CD4/CD8"]).abs() / wide["CD4/CD8"].replace(0, np.nan) + return wide + + +def match_clinical(panel: pd.DataFrame) -> pd.DataFrame: + clinical = pd.read_parquet(CLINICAL) + rows = [] + for record in panel.itertuples(index=False): + candidates = clinical.loc[clinical.dob_sex_key_hash.eq(record.dob_sex_key_hash)].copy() + if candidates.empty: + continue + candidates["flow_scan_days"] = ( + candidates.scan_timestamp - record.flow_timestamp + ).abs().dt.total_seconds() / 86400 + best = candidates.sort_values(["flow_scan_days", "scan_timestamp"]).iloc[0] + if best.flow_scan_days <= 90: + rows.append( + { + "flow_event_hash": record.flow_event_hash, + "flow_subject_hash": record.flow_subject_hash, + "scan_hash": best.scan_hash, + "flow_scan_days": float(best.flow_scan_days), + "LSM": best.LSM, + "CAP": best.CAP, + "fibrosis_stage": best.fibrosis_stage, + "qc_pass": best.qc_pass, + "BMI": best.BMI, + } + ) + return pd.DataFrame(rows) + + +def context_models(panel: pd.DataFrame) -> pd.DataFrame: + rows = [] + context = pd.Categorical(panel.context, CONTEXT_ORDER) + dummies = pd.get_dummies(context, drop_first=True, dtype=float) + sex = panel.sex.eq("M").astype(float).to_numpy() + age = (panel.age - panel.age.mean()) / panel.age.std(ddof=1) + x = np.column_stack([np.ones(len(panel)), dummies.to_numpy(float), age.to_numpy(float), sex]) + terms = ["intercept", "acute-inflammatory", "oncology/hematology", "age_z", "male"] + groups = pd.Categorical(panel.flow_subject_hash).codes + for marker in MARKERS: + y = np.log1p(panel[marker].to_numpy(float)) + y = (y - y.mean()) / y.std(ddof=1) + fit = sm.OLS(y, x).fit(cov_type="cluster", cov_kwds={"groups": groups}) + for index, term in enumerate(terms[1:3], start=1): + rows.append( + { + "marker": marker, + "comparison": f"{term} vs metabolic-dominant", + "beta_sd": float(fit.params[index]), + "se": float(fit.bse[index]), + "ci_low": float(fit.params[index] - 1.96 * fit.bse[index]), + "ci_high": float(fit.params[index] + 1.96 * fit.bse[index]), + "p_value": float(fit.pvalues[index]), + } + ) + result = pd.DataFrame(rows) + result["fdr"] = bh(result.p_value) + return result + + +def immune_pca(panel: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + features = MARKERS + matrix = np.log1p(panel[features].to_numpy(float)) + matrix = StandardScaler().fit_transform(matrix) + model = PCA(n_components=2, random_state=20260712) + coordinates = model.fit_transform(matrix) + scores = panel[["flow_event_hash", "flow_subject_hash", "flow_timestamp", "context", "age", "sex"]].copy() + scores["PC1"] = coordinates[:, 0] + scores["PC2"] = coordinates[:, 1] + loadings = pd.DataFrame( + { + "marker": features, + "PC1_loading": model.components_[0], + "PC2_loading": model.components_[1], + "PC1_variance": model.explained_variance_ratio_[0], + "PC2_variance": model.explained_variance_ratio_[1], + } + ) + return scores, loadings + + +def plot_figure(panel: pd.DataFrame, models: pd.DataFrame, pca_scores: pd.DataFrame) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(15.5, 11.5)) + grid = fig.add_gridspec(2, 3, left=.06, right=.98, bottom=.07, top=.91, wspace=.35, hspace=.36) + + ax = fig.add_subplot(grid[0, 0]) + order = panel.groupby("flow_subject_hash").flow_timestamp.min().sort_values().index + rank = {subject: i for i, subject in enumerate(order)} + for subject, local in panel.groupby("flow_subject_hash", observed=True): + local = local.sort_values("flow_timestamp") + y = rank[subject] + ax.plot(local.flow_timestamp, np.repeat(y, len(local)), color="#C8CED2", lw=.7) + ax.scatter(local.flow_timestamp, np.repeat(y, len(local)), c=local.context.map(CONTEXT_COLORS), s=17, edgecolor="white", linewidth=.3) + ax.set(xlabel="Flow-cytometry date", ylabel="Deidentified patient", yticks=[]) + locator = mdates.AutoDateLocator(minticks=4, maxticks=7) + ax.xaxis.set_major_locator(locator) + ax.xaxis.set_major_formatter(mdates.ConciseDateFormatter(locator)) + ax.set_title("A Real-world sampling architecture", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[0, 1]) + x = panel.T_fraction + .5 * panel.B_fraction + y = np.sqrt(3) / 2 * panel.B_fraction + triangle = np.array([[0,0],[1,0],[.5,np.sqrt(3)/2],[0,0]]) + ax.plot(triangle[:,0],triangle[:,1],color="#4D5559",lw=1) + ax.scatter(x,y,c=panel.context.map(CONTEXT_COLORS),s=32,alpha=.8,edgecolor="white",linewidth=.4) + ax.text(-.03,-.04,"NK",ha="right"); ax.text(1.03,-.04,"T",ha="left"); ax.text(.5,.91,"B",ha="center") + ax.set_aspect("equal"); ax.set_axis_off() + ax.set_title("B Lymphocyte composition simplex", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[0, 2]) + for context in CONTEXT_ORDER: + local = pca_scores.loc[pca_scores.context.eq(context)] + ax.scatter(local.PC1,local.PC2,s=34,color=CONTEXT_COLORS[context],label=context,alpha=.82,edgecolor="white",linewidth=.4) + ax.axhline(0,color="#D5D9DB",lw=.7); ax.axvline(0,color="#D5D9DB",lw=.7) + ax.set(xlabel="Immune PC1",ylabel="Immune PC2") + ax.set_title("C Peripheral immune-state diversity", loc="left", fontweight="bold") + ax.legend(frameon=False,fontsize=7,loc="best") + + ax = fig.add_subplot(grid[1, 0]) + plot = models.loc[models.comparison.str.startswith("acute")].copy() + plot["label"] = plot.marker.map(DISPLAY) + plot = plot.sort_values("beta_sd") + y = np.arange(len(plot)) + ax.errorbar(plot.beta_sd,y,xerr=[plot.beta_sd-plot.ci_low,plot.ci_high-plot.beta_sd],fmt="o",color=CONTEXT_COLORS["acute-inflammatory"],ecolor=CONTEXT_COLORS["acute-inflammatory"],capsize=3) + ax.axvline(0,color="#666",lw=.8) + ax.set_yticks(y,plot.label); ax.set_xlabel("Adjusted difference (SD)") + ax.set_title("D Acute-inflammatory immune displacement", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 1]) + correlation = panel[MARKERS].rename(columns=DISPLAY).corr(method="spearman") + correlation.index.name = None + correlation.columns.name = None + sns.heatmap(correlation,cmap="RdBu_r",center=0,vmin=-1,vmax=1,square=True,annot=True,fmt=".2f",annot_kws={"fontsize":7},cbar_kws={"shrink":.65},ax=ax) + ax.set_title("E Coordinated lymphocyte architecture", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 2]) + repeated = panel.groupby("flow_subject_hash").filter(lambda x: len(x)>1).copy() + repeated["days"] = repeated.groupby("flow_subject_hash").flow_timestamp.transform(lambda x:(x-x.min()).dt.total_seconds()/86400) + for subject, local in repeated.groupby("flow_subject_hash",observed=True): + local=local.sort_values("days") + ax.plot(local.days,local["CD4/CD8"],color="#87949A",lw=1,alpha=.75) + ax.scatter(local.days,local["CD4/CD8"],c=local.context.map(CONTEXT_COLORS),s=24,edgecolor="white",linewidth=.3) + ax.axhline(1,color="#C43D55",ls="--",lw=1) + ax.set(xlabel="Days from first panel",ylabel="CD4/CD8 ratio") + ax.set_title("F Within-patient immune-state mobility", loc="left", fontweight="bold") + + for ax in fig.axes: + if ax.axison: + ax.spines[["top","right"]].set_visible(False) + fig.suptitle("Peripheral lymphocyte-state diversity in fatty-liver-coded clinical encounters",fontsize=16,fontweight="bold") + fig.savefig(FIGURES / "MASLD_peripheral_lymphocyte_landscape.png",dpi=320,facecolor="white") + fig.savefig(FIGURES / "MASLD_peripheral_lymphocyte_landscape.pdf",facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser=argparse.ArgumentParser(description=__doc__) + parser.add_argument("--flow-input-dir",type=Path,default=RAW) + parser.add_argument("--clinical-linkage",type=Path,default=CLINICAL) + parser.add_argument("--hash-salt",type=Path,default=SALT_PATH) + parser.add_argument("--output-dir",type=Path,default=RESULTS) + return parser.parse_args() + + +def main() -> None: + global RAW,CLINICAL,SALT_PATH,RESULTS,FIGURES + args=parse_args() + RAW,CLINICAL,SALT_PATH,RESULTS=args.flow_input_dir,args.clinical_linkage,args.hash_salt,args.output_dir + FIGURES=RESULTS/"figures" + RESULTS.mkdir(parents=True,exist_ok=True) + FIGURES.mkdir(parents=True,exist_ok=True) + FIGURES.mkdir(parents=True,exist_ok=True) + panel=load_panel() + clinical=match_clinical(panel) + models=context_models(panel) + pca_scores,pca_loadings=immune_pca(panel) + plot_figure(panel,models,pca_scores) + + safe_columns=[ + "flow_event_hash","flow_subject_hash","dob_sex_key_hash","flow_timestamp","sex","age","context", + "diabetes","hypertension","viral_hepatitis","liver_dysfunction",*MARKERS, + "NK_fraction","T_fraction","B_fraction","CD4_T_fraction","CD8_T_fraction","ratio_relative_error", + ] + panel[safe_columns].to_parquet(RESULTS/"flow_panel_deidentified.parquet",index=False) + panel[safe_columns].to_csv(RESULTS/"flow_panel_deidentified.tsv",sep="\t",index=False) + models.to_csv(RESULTS/"flow_context_models.tsv",sep="\t",index=False) + pca_scores.to_csv(RESULTS/"flow_immune_pca_scores.tsv",sep="\t",index=False) + pca_loadings.to_csv(RESULTS/"flow_immune_pca_loadings.tsv",sep="\t",index=False) + clinical.to_csv(RESULTS/"flow_liver_stiffness_90d_linkage.tsv",sep="\t",index=False) + + context_counts=panel.groupby("context",observed=True).agg(panels=("flow_event_hash","size"),patients=("flow_subject_hash","nunique")).reset_index() + context_counts.to_csv(RESULTS/"flow_context_counts.tsv",sep="\t",index=False) + summary={ + "n_rows_original":int(len(panel)*len(MARKERS)), + "n_complete_panels":int(len(panel)), + "n_patients":int(panel.flow_subject_hash.nunique()), + "n_repeated_patients":int((panel.groupby("flow_subject_hash").size()>1).sum()), + "max_panels_per_patient":int(panel.groupby("flow_subject_hash").size().max()), + "context_counts":context_counts.to_dict(orient="records"), + "median_ratio_relative_error":float(panel.ratio_relative_error.median()), + "n_liver_stiffness_links_90d":int(len(clinical)), + "role_in_manuscript":"Independent real-world peripheral immune-state atlas and longitudinal supplement; not a fibrosis-stage association cohort.", + } + (RESULTS/"flow_analysis_summary.json").write_text(json.dumps(summary,ensure_ascii=False,indent=2)+"\n") + print(json.dumps(summary,ensure_ascii=False,indent=2)) + + +if __name__=="__main__": + main() diff --git a/code/clinical/rebuild_final_clinical_visuals.py b/code/clinical/rebuild_final_clinical_visuals.py new file mode 100644 index 0000000..755c142 --- /dev/null +++ b/code/clinical/rebuild_final_clinical_visuals.py @@ -0,0 +1,966 @@ +#!/usr/bin/env python3 +"""Rebuild the proprietary clinical evidence layer and publication figures.""" + +from __future__ import annotations + +import argparse +import json +import math +from pathlib import Path + +import matplotlib as mpl +import matplotlib.pyplot as plt +from matplotlib.gridspec import GridSpec +from matplotlib.patches import FancyBboxPatch, PathPatch, Rectangle +from matplotlib.path import Path as MplPath +from mpl_toolkits.axes_grid1.inset_locator import inset_axes +import numpy as np +import pandas as pd +import seaborn as sns +from scipy.stats import norm +import statsmodels.api as sm +import statsmodels.formula.api as smf +from sklearn.linear_model import LogisticRegression +from sklearn.metrics import brier_score_loss, roc_auc_score +from sklearn.model_selection import StratifiedKFold, cross_val_predict +from sklearn.pipeline import make_pipeline +from sklearn.preprocessing import StandardScaler + + +SCRIPT = Path(__file__).resolve() +REPO_ROOT = SCRIPT.parents[2] +CLIN = REPO_ROOT / "data/governed/clinical" +DYN = REPO_ROOT / "data/governed/dynamics" +OUTPUT_ROOT = REPO_ROOT / "results/clinical" +TABLES = OUTPUT_ROOT / "source_tables" +MAIN = OUTPUT_ROOT / "main_figures" +ED = OUTPUT_ROOT / "extended_data_figures" +LOGS = OUTPUT_ROOT / "logs" + + +COLORS = { + "blue": "#2678B2", + "cyan": "#47B5C4", + "teal": "#2A9D8F", + "gold": "#E9C46A", + "orange": "#F4A261", + "red": "#D1495B", + "magenta": "#B05A8F", + "purple": "#6C5B7B", + "gray": "#8A8F98", + "lightgray": "#E8EAED", + "dark": "#20242A", +} +STATE_COLORS = { + "LL": "#4C9F70", + "HL": "#E9C46A", + "LH": "#8F6BAE", + "HH": "#D1495B", +} +STATE_LABELS = { + "LL": "Low CAP / low LSM", + "HL": "High CAP / low LSM", + "LH": "Low CAP / high LSM", + "HH": "High CAP / high LSM", +} + + +mpl.rcParams.update( + { + "font.family": "sans-serif", + "font.sans-serif": ["Arial", "Helvetica", "DejaVu Sans"], + "font.size": 8, + "axes.titlesize": 9, + "axes.labelsize": 8, + "xtick.labelsize": 7, + "ytick.labelsize": 7, + "legend.fontsize": 7, + "axes.linewidth": 0.8, + "figure.dpi": 160, + "savefig.dpi": 360, + "savefig.bbox": "tight", + "svg.fonttype": "none", + "pdf.fonttype": 42, + "ps.fonttype": 42, + "axes.spines.top": False, + "axes.spines.right": False, + "axes.grid": False, + "text.color": COLORS["dark"], + "axes.labelcolor": COLORS["dark"], + "xtick.color": COLORS["dark"], + "ytick.color": COLORS["dark"], + } +) +sns.set_style("white") + + +def panel(ax: plt.Axes, letter: str, title: str) -> None: + ax.text(-0.08, 1.06, letter, transform=ax.transAxes, fontsize=13, fontweight="bold", va="top") + ax.set_title(title, loc="left", fontsize=9.5, fontweight="bold", pad=7) + + +def save_figure(fig: plt.Figure, stem: Path) -> None: + for ext in ["png", "pdf", "svg"]: + fig.savefig(stem.with_suffix(f".{ext}"), facecolor="white") + plt.close(fig) + + +def median_iqr(s: pd.Series, digits: int = 1) -> str: + x = pd.to_numeric(s, errors="coerce").dropna() + q1, med, q3 = x.quantile([0.25, 0.5, 0.75]) + return f"{med:.{digits}f} [{q1:.{digits}f}, {q3:.{digits}f}]" + + +def n_pct(mask: pd.Series) -> str: + x = mask.dropna().astype(bool) + return f"{int(x.sum()):,} ({100 * x.mean():.1f}%)" + + +def smd_cont(a: pd.Series, b: pd.Series) -> float: + a = pd.to_numeric(a, errors="coerce").dropna() + b = pd.to_numeric(b, errors="coerce").dropna() + pooled = math.sqrt((a.var(ddof=1) + b.var(ddof=1)) / 2) + return float((b.mean() - a.mean()) / pooled) if pooled > 0 else np.nan + + +def smd_binary(a: pd.Series, b: pd.Series) -> float: + pa, pb = a.astype(float).mean(), b.astype(float).mean() + pooled = math.sqrt((pa * (1 - pa) + pb * (1 - pb)) / 2) + return float((pb - pa) / pooled) if pooled > 0 else np.nan + + +def bootstrap_auc(y: np.ndarray, p: np.ndarray, n_boot: int = 1200, seed: int = 20260712) -> tuple[float, float, float]: + y = np.asarray(y, dtype=int) + p = np.asarray(p, dtype=float) + estimate = roc_auc_score(y, p) + rng = np.random.default_rng(seed) + vals: list[float] = [] + n = len(y) + for _ in range(n_boot): + ind = rng.integers(0, n, n) + if np.unique(y[ind]).size == 2: + vals.append(roc_auc_score(y[ind], p[ind])) + lo, hi = np.quantile(vals, [0.025, 0.975]) + return float(estimate), float(lo), float(hi) + + +def odds_ratio_glm(data: pd.DataFrame, outcome: str, predictor: str) -> tuple[float, float, float, float]: + d = data[[outcome, predictor]].dropna().copy() + d[outcome] = d[outcome].astype(int) + d[predictor] = (d[predictor] - d[predictor].mean()) / d[predictor].std(ddof=1) + model = sm.GLM(d[outcome], sm.add_constant(d[predictor]), family=sm.families.Binomial()).fit() + beta = model.params[predictor] + lo, hi = model.conf_int().loc[predictor] + return float(np.exp(beta)), float(np.exp(lo)), float(np.exp(hi)), float(model.pvalues[predictor]) + + +def state_code(cap: pd.Series, lsm: pd.Series) -> pd.Series: + return pd.Series( + np.select( + [ + (cap < 280) & (lsm < 9.5), + (cap >= 280) & (lsm < 9.5), + (cap < 280) & (lsm >= 9.5), + (cap >= 280) & (lsm >= 9.5), + ], + ["LL", "HL", "LH", "HH"], + default="NA", + ), + index=cap.index, + ) + + +def build_longitudinal(elasto: pd.DataFrame) -> pd.DataFrame: + rows: list[dict[str, object]] = [] + for pid, group in elasto.groupby("medical_record_hash", sort=False): + group = group.drop_duplicates("scan_date").sort_values("scan_timestamp") + if len(group) < 2: + continue + first, last = group.iloc[0], group.iloc[-1] + days = int((last.scan_date - first.scan_date).days) + if days < 90: + continue + rows.append( + { + "patient": pid, + "n_scans": len(group), + "baseline_date": first.scan_date, + "followup_days": days, + "age": first.age_at_scan, + "male": int(first.sex == "M"), + "BMI": first.BMI, + "CAP0": first.CAP, + "CAP1": last.CAP, + "LSM0": first.LSM, + "LSM1": last.LSM, + } + ) + d = pd.DataFrame(rows) + d["state0"] = state_code(d.CAP0, d.LSM0) + d["state1"] = state_code(d.CAP1, d.LSM1) + d["delta_CAP"] = d.CAP1 - d.CAP0 + d["relative_LSM"] = d.LSM1 / d.LSM0 - 1 + d["advanced0"] = d.LSM0 >= 9.5 + d["advanced1"] = d.LSM1 >= 9.5 + d["outcome"] = np.select( + [ + d.advanced0 & ~d.advanced1, + ~d.advanced0 & d.advanced1, + d.advanced0 & d.advanced1, + ~d.advanced0 & ~d.advanced1, + ], + ["Threshold regression", "Threshold progression", "Persistent advanced", "Persistent nonadvanced"], + default="Unknown", + ) + d["lsm_change"] = np.select( + [d.relative_LSM <= -0.20, d.relative_LSM >= 0.20], + ["Decrease >=20%", "Increase >=20%"], + default="Stable within 20%", + ) + d["regression_resistant"] = d.advanced0 & d.advanced1 & (d.relative_LSM > -0.20) + d["baseline_era"] = np.where(d.baseline_date.dt.year <= 2024, "2023-2024", "2025-2026") + return d + + +def baseline_table(index: pd.DataFrame) -> pd.DataFrame: + low = index.loc[~index.advanced_fibrosis_lsm_ge9_5] + high = index.loc[index.advanced_fibrosis_lsm_ge9_5] + specs = [ + ("Age, years", "continuous", "age_at_scan", 1), + ("Male sex", "binary", "male", 1), + ("BMI, kg/m2", "continuous", "BMI", 1), + ("CAP, dB/m", "continuous", "CAP", 1), + ("LSM, kPa", "continuous", "LSM", 1), + ("CAP >=248 dB/m", "binary", "cap248", 1), + ("CAP >=280 dB/m", "binary", "cap280", 1), + ("LSM 9.5-<12.5 kPa", "binary", "f3", 1), + ("LSM >=12.5 kPa", "binary", "f4", 1), + ("Gastro/hepatobiliary", "binary", "gi", 1), + ] + rows = [] + for label, kind, col, digits in specs: + if kind == "continuous": + rows.append( + { + "Variable": label, + "All (n=8,142)": median_iqr(index[col], digits), + "LSM <9.5 (n=5,857)": median_iqr(low[col], digits), + "LSM >=9.5 (n=2,285)": median_iqr(high[col], digits), + "SMD": smd_cont(low[col], high[col]), + } + ) + else: + rows.append( + { + "Variable": label, + "All (n=8,142)": n_pct(index[col]), + "LSM <9.5 (n=5,857)": n_pct(low[col]), + "LSM >=9.5 (n=2,285)": n_pct(high[col]), + "SMD": smd_binary(low[col], high[col]), + } + ) + return pd.DataFrame(rows) + + +def validation_analysis(index: pd.DataFrame) -> pd.DataFrame: + features = ["age_at_scan", "male", "BMI", "CAP"] + train = index.loc[index.scan_date.dt.year <= 2024].copy() + temporal = index.loc[index.scan_date.dt.year >= 2025].copy() + model = make_pipeline(StandardScaler(), LogisticRegression(max_iter=2000, random_state=20260712)) + cv = StratifiedKFold(5, shuffle=True, random_state=20260712) + cv_pred = cross_val_predict(model, train[features], train.advanced.astype(int), cv=cv, method="predict_proba")[:, 1] + model.fit(train[features], train.advanced.astype(int)) + temporal_pred = model.predict_proba(temporal[features])[:, 1] + + gi = index.loc[index.gi].copy() + other = index.loc[~index.gi].copy() + dept_model = make_pipeline(StandardScaler(), LogisticRegression(max_iter=2000, random_state=20260712)) + dept_model.fit(gi[features], gi.advanced.astype(int)) + other_pred = dept_model.predict_proba(other[features])[:, 1] + + rows = [] + for label, data, pred in [ + ("Internal 5-fold CV (2023-2024)", train, cv_pred), + ("Temporal holdout (2025-2026)", temporal, temporal_pred), + ("Independent department subcohort", other, other_pred), + ]: + est, lo, hi = bootstrap_auc(data.advanced.to_numpy(), pred) + rows.append( + { + "validation": label, + "n": len(data), + "advanced_n": int(data.advanced.sum()), + "advanced_fraction": float(data.advanced.mean()), + "AUROC": est, + "ci_low": lo, + "ci_high": hi, + "Brier": brier_score_loss(data.advanced.astype(int), pred), + } + ) + return pd.DataFrame(rows) + + +def draw_workflow(ax: plt.Axes) -> None: + ax.set_axis_off() + panel(ax, "A", "Proprietary clinical cohort, fixed eligibility, and de-identification workflow") + items = [ + ("Raw elastography", "9,703 scans\n2023-03-01 to 2026-07-09", COLORS["blue"]), + ("Technical QC", "9,644 scans\n>=10 valid; LSM IQR/M <=0.30", COLORS["cyan"]), + ("Adult analysis", "9,562 scans\nage >=18 years", COLORS["teal"]), + ("Index cohort", "8,142 patients\none scan per hashed MRN", COLORS["gold"]), + ("Clinical linkage", "Metabolic 1,490 | LIS 746\nthree-source 243 scans", COLORS["red"]), + ] + x0, gap, width, height, y = 0.015, 0.018, 0.175, 0.60, 0.18 + for i, (head, body, color) in enumerate(items): + x = x0 + i * (width + gap) + box = FancyBboxPatch( + (x, y), width, height, + boxstyle="round,pad=0.008,rounding_size=0.008", + facecolor="white", edgecolor=color, linewidth=1.6, + transform=ax.transAxes, + ) + ax.add_patch(box) + ax.add_patch(Rectangle((x, y + height - 0.11), width, 0.11, transform=ax.transAxes, facecolor=color, edgecolor="none", alpha=0.95)) + ax.text(x + 0.012, y + height - 0.055, head, transform=ax.transAxes, color="white", fontweight="bold", va="center", fontsize=8.2) + ax.text(x + width / 2, y + 0.24, body, transform=ax.transAxes, ha="center", va="center", fontsize=7.2, linespacing=1.25) + if i < len(items) - 1: + ax.annotate("", xy=(x + width + gap - 0.004, y + height / 2), xytext=(x + width + 0.004, y + height / 2), xycoords=ax.transAxes, arrowprops=dict(arrowstyle="-|>", color=COLORS["gray"], lw=1.2)) + ax.text(0.015, 0.02, "Single center: Fudan University Affiliated Pudong Hospital", transform=ax.transAxes, fontsize=7.4, fontweight="bold") + ax.text(0.42, 0.02, "Linkage: laboratory-verified unique patient key; nearest result within +/-90 days", transform=ax.transAxes, fontsize=7.2) + ax.text(0.985, 0.02, "Ethics details: AUTHORS TO COMPLETE BEFORE SUBMISSION", transform=ax.transAxes, ha="right", fontsize=7.2, color=COLORS["red"], fontweight="bold") + + +def figure_main_1(index: pd.DataFrame, baseline: pd.DataFrame, etiology: pd.DataFrame, validation: pd.DataFrame) -> None: + fig = plt.figure(figsize=(16.2, 10.4)) + gs = GridSpec(3, 12, figure=fig, height_ratios=[1.25, 3.1, 2.8], hspace=0.55, wspace=1.00) + draw_workflow(fig.add_subplot(gs[0, :])) + + ax = fig.add_subplot(gs[1:, :4]) + panel(ax, "B", "Baseline profile of 8,142 adults") + ax.axis("off") + show = baseline.copy().rename( + columns={ + "All (n=8,142)": "All\n(n=8,142)", + "LSM <9.5 (n=5,857)": "LSM <9.5\n(n=5,857)", + "LSM >=9.5 (n=2,285)": "LSM >=9.5\n(n=2,285)", + } + ) + show["SMD"] = show.SMD.map(lambda x: f"{x:.2f}") + table = ax.table(cellText=show.values, colLabels=show.columns, cellLoc="left", colLoc="left", bbox=[0, 0.01, 1, 0.96], colWidths=[0.34, 0.22, 0.23, 0.23, 0.08]) + table.auto_set_font_size(False) + table.set_fontsize(6.1) + for (row, col), cell in table.get_celld().items(): + cell.set_edgecolor("white") + if row == 0: + cell.set_facecolor(COLORS["dark"]) + cell.get_text().set_color("white") + cell.get_text().set_fontweight("bold") + elif row % 2 == 0: + cell.set_facecolor("#F4F5F6") + if col == 0 and row > 0: + cell.get_text().set_fontweight("bold") + ax.text(0, -0.03, "Values are median [IQR] or n (%). SMD compares LSM strata.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + ax = fig.add_subplot(gs[1, 4:8]) + panel(ax, "C", "LSM-defined imaging strata across calendar years") + stage_order = ["<8.0", "8.0-<9.5", "9.5-<12.5", ">=12.5"] + stage_colors = [COLORS["teal"], COLORS["gold"], COLORS["orange"], COLORS["red"]] + imaging_stratum = pd.cut(index.LSM, [-np.inf, 8.0, 9.5, 12.5, np.inf], right=False, labels=stage_order) + tab = pd.crosstab(index.scan_date.dt.year, imaging_stratum).reindex(columns=stage_order, fill_value=0) + pct = tab.div(tab.sum(axis=1), axis=0) * 100 + bottom = np.zeros(len(pct)) + for stage, color in zip(stage_order, stage_colors): + ax.bar(pct.index.astype(str), pct[stage], bottom=bottom, color=color, width=0.68, label=stage, edgecolor="white", linewidth=0.5) + bottom += pct[stage].to_numpy() + for i, year in enumerate(pct.index): + ax.text(i, 102, f"n={tab.loc[year].sum():,}", ha="center", va="bottom", fontsize=6.5) + ax.set_ylim(0, 109) + ax.set_ylabel("Patients (%)") + ax.set_xlabel("Index year") + ax.legend(frameon=False, ncol=4, loc="lower center", bbox_to_anchor=(0.5, -0.28), title="LSM (kPa)") + + ax = fig.add_subplot(gs[1, 8:12]) + panel(ax, "D", "CAP-LSM landscape separates steatotic and stiffness axes") + hb = ax.hexbin(index.CAP, index.LSM, gridsize=48, mincnt=1, bins="log", cmap="viridis", linewidths=0, extent=[150, 400, 2.5, 33]) + ax.axvline(280, color=COLORS["red"], ls="--", lw=1.1) + ax.axhline(9.5, color=COLORS["red"], ls="--", lw=1.1) + counts = index.state.value_counts() + positions = {"LL": (175, 4.5), "HL": (316, 4.5), "LH": (175, 27.5), "HH": (316, 27.5)} + for st, (x, y) in positions.items(): + ax.text(x, y, f"{st}\nn={counts.get(st, 0):,}", ha="center", va="center", fontsize=7.2, fontweight="bold", bbox=dict(boxstyle="round,pad=0.25", fc="white", ec=STATE_COLORS[st], lw=1.1, alpha=0.9)) + ax.set_xlim(150, 400) + ax.set_ylim(2.5, 33) + ax.set_xlabel("CAP (dB/m)") + ax.set_ylabel("LSM (kPa)") + cb = fig.colorbar(hb, ax=ax, fraction=0.047, pad=0.02) + cb.set_label("log10 density", fontsize=7) + ax.text(0.02, 0.02, "Spearman rho=0.385", transform=ax.transAxes, fontsize=6.8, bbox=dict(fc="white", ec="none", alpha=0.8)) + top = inset_axes(ax, width="82%", height="15%", loc="upper left", borderpad=0.6) + top.hist(index.CAP, bins=44, color=COLORS["blue"], alpha=0.55) + top.patch.set_alpha(0.82) + top.axis("off") + right = inset_axes(ax, width="15%", height="72%", loc="upper right", borderpad=0.6) + right.hist(index.LSM, bins=38, orientation="horizontal", color=COLORS["purple"], alpha=0.55) + right.patch.set_alpha(0.82) + right.axis("off") + + ax = fig.add_subplot(gs[2, 4:8]) + panel(ax, "E", "Observed etiology markers and partial phenotypes") + order = [ + "metabolic_risk_observed", + "metabolic_steatotic_phenotype", + "diagnosis_steatotic_liver_text", + "HBsAg_marker_positive", + "AMA_M2_marker_positive", + "anti_HCV_marker_positive", + ] + labels = { + "metabolic_risk_observed": "Metabolic risk", + "metabolic_steatotic_phenotype": "CAP >=248 + metabolic", + "diagnosis_steatotic_liver_text": "Steatotic-liver text", + "HBsAg_marker_positive": "HBsAg positive", + "AMA_M2_marker_positive": "AMA-M2 positive", + "anti_HCV_marker_positive": "anti-HCV positive", + } + d = etiology.set_index("marker_or_phenotype").loc[order].reset_index() + y = np.arange(len(d))[::-1] + ax.barh(y, 100 * d.proportion, color=[COLORS["gold"], COLORS["orange"], COLORS["gray"], COLORS["blue"], COLORS["magenta"], COLORS["purple"]], height=0.65) + ax.set_yticks(y, [labels[x] for x in d.marker_or_phenotype]) + ax.tick_params(axis="y", labelsize=6.4, pad=2) + ax.set_xlabel("Positive among observed (%)") + ax.set_xlim(0, 100) + for yi, row in zip(y, d.itertuples()): + ax.text(min(98, 100 * row.proportion + 2), yi, f"{row.n_positive}/{row.n_observed}", va="center", fontsize=6.8) + ax.text(0.0, -0.25, "Markers and text-derived phenotypes are not adjudicated etiologies.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + ax = fig.add_subplot(gs[2, 8:12]) + panel(ax, "F", "Internal, temporal, and independent-subcohort validation") + y = np.arange(len(validation))[::-1] + short_validation = { + "Internal 5-fold CV (2023-2024)": "Internal 5-fold CV\n2023-2024", + "Temporal holdout (2025-2026)": "Temporal holdout\n2025-2026", + "Independent department subcohort": "Other-department\nsubcohort", + } + for yi, row in zip(y, validation.itertuples()): + ax.errorbar(row.AUROC, yi, xerr=[[row.AUROC - row.ci_low], [row.ci_high - row.AUROC]], fmt="o", color=COLORS["blue"], capsize=3, lw=1.3, ms=6) + ax.text(row.ci_high + 0.012, yi, f"{row.AUROC:.3f} ({row.ci_low:.3f}-{row.ci_high:.3f})", va="center", fontsize=6.8) + ax.axvline(0.5, color=COLORS["gray"], ls="--", lw=1) + ax.set_yticks(y, [f"{short_validation[r.validation]}\nn={r.n:,}" for r in validation.itertuples()]) + ax.tick_params(axis="y", labelsize=6.4, pad=2) + ax.set_xlim(0.45, 0.86) + ax.set_xlabel("AUROC for LSM >=9.5 kPa") + ax.text(0.0, -0.25, "Frozen predictors: age, sex, BMI, and CAP. Other-department validation excludes gastro/hepatobiliary sources.", transform=ax.transAxes, fontsize=6.7, color=COLORS["gray"]) + + fig.suptitle("Figure 1 | Proprietary clinical cohort architecture and baseline landscape", x=0.02, y=0.995, ha="left", fontsize=13, fontweight="bold") + save_figure(fig, MAIN / "Figure_1") + + +def draw_alluvial(ax: plt.Axes, matrix: pd.DataFrame) -> None: + order = ["LL", "HL", "LH", "HH"] + matrix = matrix.reindex(index=order, columns=order, fill_value=0) + total = matrix.to_numpy().sum() + left_totals = matrix.sum(axis=1).to_numpy() + right_totals = matrix.sum(axis=0).to_numpy() + gap = 0.025 + usable = 0.90 - gap * (len(order) - 1) + + def spans(totals: np.ndarray) -> dict[str, tuple[float, float]]: + cursor = 0.05 + out = {} + for st, n in zip(order, totals): + h = usable * n / total + out[st] = (cursor, cursor + h) + cursor += h + gap + return out + + left = spans(left_totals) + right = spans(right_totals) + left_cursor = {k: v[0] for k, v in left.items()} + right_cursor = {k: v[0] for k, v in right.items()} + x0, x1, node_w = 0.17, 0.82, 0.035 + + for a in order: + for b in order: + n = matrix.loc[a, b] + if n <= 0: + continue + h = usable * n / total + y0a, y0b = left_cursor[a], left_cursor[a] + h + y1a, y1b = right_cursor[b], right_cursor[b] + h + left_cursor[a] += h + right_cursor[b] += h + verts = [ + (x0 + node_w, y0a), + (0.43, y0a), + (0.57, y1a), + (x1, y1a), + (x1, y1b), + (0.57, y1b), + (0.43, y0b), + (x0 + node_w, y0b), + (x0 + node_w, y0a), + ] + codes = [MplPath.MOVETO, MplPath.CURVE4, MplPath.CURVE4, MplPath.CURVE4, MplPath.LINETO, MplPath.CURVE4, MplPath.CURVE4, MplPath.CURVE4, MplPath.CLOSEPOLY] + ax.add_patch(PathPatch(MplPath(verts, codes), facecolor=STATE_COLORS[a], edgecolor="none", alpha=0.40)) + + for st in order: + for x, mapping, totals in [(x0, left, left_totals), (x1, right, right_totals)]: + y0, y1 = mapping[st] + ax.add_patch(Rectangle((x, y0), node_w, y1 - y0, facecolor=STATE_COLORS[st], edgecolor="white", lw=0.6)) + y0, y1 = left[st] + ax.text(x0 - 0.015, (y0 + y1) / 2, f"{st} {matrix.loc[st].sum():,}", ha="right", va="center", fontsize=7) + y0, y1 = right[st] + ax.text(x1 + node_w + 0.015, (y0 + y1) / 2, f"{matrix[st].sum():,} {st}", ha="left", va="center", fontsize=7) + ax.text(x0, 0.985, "Baseline", ha="left", va="top", fontweight="bold", fontsize=7.5) + ax.text(x1 + node_w, 0.985, "Final", ha="right", va="top", fontweight="bold", fontsize=7.5) + ax.text(0.50, 0.015, f"n={total:,}; median follow-up 292 days", ha="center", fontsize=6.8, color=COLORS["gray"]) + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + ax.axis("off") + + +def serum_associations(score: pd.DataFrame) -> pd.DataFrame: + rows = [] + labels = { + "SDS_v0": "Composite SDS_v0", + "axis_ECM": "ECM retention axis", + "axis_cholestatic": "Cholestatic-support axis", + "axis_portal_synthetic": "Portal/synthetic deficit axis", + } + for col in labels: + or_, lo, hi, p = odds_ratio_glm(score, "advanced_fibrosis_by_LSM", col) + rows.append({"term": labels[col], "OR": or_, "ci_low": lo, "ci_high": hi, "p": p, "n": len(score)}) + return pd.DataFrame(rows) + + +def figure_main_2(longitudinal: pd.DataFrame, score: pd.DataFrame, serum_or: pd.DataFrame) -> None: + fig = plt.figure(figsize=(16.2, 11.0)) + gs = GridSpec(3, 12, figure=fig, height_ratios=[1.35, 3.3, 3.1], hspace=0.62, wspace=1.35) + + ax = fig.add_subplot(gs[0, :]) + ax.axis("off") + panel(ax, "A", "Operational bridge from tissue mechanism to measurable clinical states") + cards = [ + ("Imaging retention", "LSM >=9.5 kPa while CAP <280 dB/m\n885/8,142 baseline patients", COLORS["purple"]), + ("Serum imbalance", "ECM 50% + cholestatic support 25%\n+ inverse portal/synthetic reserve 25%", COLORS["red"]), + ("Imaging persistence", "Advanced LSM persists and falls <20%\nafter >=90 days", COLORS["gold"]), + ("Outcome boundary", "Imaging-defined progression/regression only\nno adjudicated readmission or treatment exposure", COLORS["gray"]), + ] + for i, (head, body, color) in enumerate(cards): + x, w = 0.025 + i * 0.245, 0.22 + ax.add_patch(FancyBboxPatch((x, 0.18), w, 0.62, boxstyle="round,pad=0.01,rounding_size=0.008", transform=ax.transAxes, fc="white", ec=color, lw=1.6)) + ax.text(x + 0.015, 0.69, head, transform=ax.transAxes, color=color, fontsize=8.5, fontweight="bold") + ax.text(x + 0.015, 0.43, body, transform=ax.transAxes, fontsize=7.1, va="center", linespacing=1.35) + if i < len(cards) - 1: + ax.annotate("", xy=(x + w + 0.021, 0.49), xytext=(x + w + 0.004, 0.49), xycoords=ax.transAxes, arrowprops=dict(arrowstyle="-|>", color=COLORS["gray"], lw=1.1)) + + ax = fig.add_subplot(gs[1:, :5]) + panel(ax, "B", "Four-state longitudinal flow in 772 repeat patients") + flow = pd.crosstab(longitudinal.state0, longitudinal.state1) + draw_alluvial(ax, flow) + + ax = fig.add_subplot(gs[1, 5:8]) + panel(ax, "C", "Imaging-defined longitudinal outcomes") + order = ["Persistent nonadvanced", "Threshold regression", "Persistent advanced", "Threshold progression"] + colors = [COLORS["teal"], COLORS["blue"], COLORS["red"], COLORS["orange"]] + counts = longitudinal.outcome.value_counts().reindex(order) + bars = ax.barh(np.arange(4)[::-1], counts.values, color=colors, height=0.65) + ax.set_yticks(np.arange(4)[::-1], ["Nonadvanced", "Regressed", "Advanced persistent", "Progressed"]) + ax.tick_params(axis="y", labelsize=6.3, pad=2) + ax.set_xlabel("Patients") + for bar, n in zip(bars, counts.values): + ax.text(n + 7, bar.get_y() + bar.get_height() / 2, f"{n:,} ({100*n/len(longitudinal):.1f}%)", va="center", fontsize=6.8) + ax.set_xlim(0, max(counts) * 1.27) + + ax = fig.add_subplot(gs[1, 8:12]) + panel(ax, "D", "CAP and LSM can change nonreciprocally") + cap_change = pd.cut(longitudinal.delta_CAP, [-np.inf, -20, 20, np.inf], labels=["CAP down >=20", "CAP stable", "CAP up >=20"]) + lsm_change = pd.cut(longitudinal.relative_LSM, [-np.inf, -0.20, 0.20, np.inf], labels=["LSM down >=20%", "LSM stable", "LSM up >=20%"]) + mat = pd.crosstab(cap_change, lsm_change).reindex(index=["CAP down >=20", "CAP stable", "CAP up >=20"], columns=["LSM down >=20%", "LSM stable", "LSM up >=20%"], fill_value=0) + sns.heatmap(mat, annot=True, fmt="d", cmap="Blues", cbar_kws={"label": "Patients"}, ax=ax, linewidths=1, linecolor="white") + ax.set_xlabel("") + ax.set_ylabel("") + ax.tick_params(axis="x", rotation=20) + ax.tick_params(axis="y", rotation=0) + subset = longitudinal[(longitudinal.CAP0 >= 0) & (longitudinal.LSM0 >= 9.5) & (longitudinal.delta_CAP <= -20)] + persistent = int(subset.advanced1.sum()) + ax.text(0.0, -0.30, f"Among baseline advanced cases with CAP falling >=20 dB/m, {persistent}/{len(subset)} ({100*persistent/len(subset):.1f}%) remained advanced.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + ax = fig.add_subplot(gs[2, 5:8]) + panel(ax, "E", "Imaging persistence by baseline state") + high = longitudinal.loc[longitudinal.advanced0 & longitudinal.state0.isin(["LH", "HH"])].copy() + summary = high.groupby("state0").agg(n=("patient", "size"), persistent=("advanced1", "mean"), resistant=("regression_resistant", "mean")).reindex(["LH", "HH"]) + x = np.arange(2) + ax.bar(x - 0.17, 100 * summary.persistent, width=0.34, color=COLORS["purple"], label="Persistent advanced") + ax.bar(x + 0.17, 100 * summary.resistant, width=0.34, color=COLORS["gold"], label="Persistent + <20% LSM fall") + ax.set_xticks(x, [f"{STATE_LABELS[s]}\nn={summary.loc[s, 'n']:,}" for s in summary.index]) + ax.set_ylabel("Patients (%)") + ax.set_ylim(0, 70) + ax.legend(frameon=False, loc="upper right") + for xi, st in enumerate(summary.index): + ax.text(xi - 0.17, 100 * summary.loc[st, "persistent"] + 2, f"{100*summary.loc[st, 'persistent']:.1f}", ha="center", fontsize=6.6) + ax.text(xi + 0.17, 100 * summary.loc[st, "resistant"] + 2, f"{100*summary.loc[st, 'resistant']:.1f}", ha="center", fontsize=6.6) + ax.text(0, -0.31, "Persistence is imaging-defined, not adjudicated biological regression or treatment failure.", transform=ax.transAxes, fontsize=6.7, color=COLORS["gray"]) + + ax = fig.add_subplot(gs[2, 8:12]) + panel(ax, "F", "Serum imbalance and advanced LSM") + short_terms = { + "Composite SDS_v0": "SDS_v0", + "ECM retention axis": "ECM", + "Cholestatic-support axis": "Cholestatic", + "Portal/synthetic deficit axis": "Portal/synthetic", + } + y = np.arange(len(serum_or))[::-1] + for yi, row in zip(y, serum_or.itertuples()): + ax.errorbar(row.OR, yi, xerr=[[row.OR - row.ci_low], [row.ci_high - row.OR]], fmt="o", color=COLORS["red"] if row.term == "Composite SDS_v0" else COLORS["blue"], capsize=3, lw=1.2, ms=5.5) + ax.text(row.ci_high + 0.15, yi, f"OR {row.OR:.2f} ({row.ci_low:.2f}-{row.ci_high:.2f}); P={row.p:.3f}", va="center", fontsize=6.5) + ax.axvline(1, color=COLORS["gray"], ls="--", lw=1) + ax.set_yticks(y, [short_terms[x] for x in serum_or.term]) + ax.tick_params(axis="y", labelsize=6.3, pad=2) + ax.set_xscale("log") + ax.set_xlim(0.22, 10.5) + ax.set_xlabel("Odds ratio per 1-SD increase for LSM >=9.5 kPa") + ax.text(0.0, -0.30, "n=46 complete cases; fixed outcome-independent weights; AUROC 0.688 (95% CI 0.497-0.862).", transform=ax.transAxes, fontsize=6.7, color=COLORS["gray"]) + + fig.suptitle("Figure 2 | Clinical persistence phenotype and longitudinal outcomes", x=0.02, y=0.995, ha="left", fontsize=13, fontweight="bold") + save_figure(fig, MAIN / "Figure_2") + + +def figure_ed1(index: pd.DataFrame, matched_index: pd.DataFrame) -> None: + fig, axes = plt.subplots(2, 2, figsize=(13.5, 9.2), gridspec_kw={"hspace": 0.52, "wspace": 0.38}) + ax = axes[0, 0] + panel(ax, "A", "Cohort attrition and denominator changes") + labels = ["Raw scans", "Technical QC", "Adult QC scans", "Adult index patients"] + values = [9703, 9644, 9562, 8142] + colors = [COLORS["blue"], COLORS["cyan"], COLORS["teal"], COLORS["gold"]] + y = np.arange(4)[::-1] + ax.barh(y, values, color=colors, height=0.68) + ax.set_yticks(y, labels) + ax.set_xlabel("Records") + ax.set_xlim(0, 10500) + for yi, v in zip(y, values): + ax.text(v + 120, yi, f"{v:,}", va="center", fontsize=7) + + ax = axes[0, 1] + panel(ax, "B", "Variable-specific 90-day linkage completeness") + variables = ["TG", "HDL", "UA", "FPG", "AST", "ALT", "GGT", "ALB", "PLT", "HA", "CIV", "LN", "PIIINP"] + completeness = matched_index[variables].notna().mean().sort_values() + ax.barh(np.arange(len(completeness)), 100 * completeness.values, color=[COLORS["teal"] if v > 0.1 else COLORS["gray"] for v in completeness.values], height=0.68) + ax.set_yticks(np.arange(len(completeness)), completeness.index) + ax.set_xlabel("Index patients with matched value (%)") + ax.set_xlim(0, max(20, 100 * completeness.max() * 1.15)) + for yi, v in enumerate(completeness.values): + ax.text(100 * v + 0.3, yi, f"{100*v:.1f}", va="center", fontsize=6.5) + + ax = axes[1, 0] + panel(ax, "C", "Absolute linkage offsets by analyte") + vars_off = ["TG", "HDL", "AST", "GGT", "PLT", "HA"] + data = [] + for var in vars_off: + vals = matched_index[f"{var}_off_days"].dropna().abs() + data.extend([(var, x) for x in vals]) + off = pd.DataFrame(data, columns=["analyte", "days"]) + sns.boxplot(data=off, x="analyte", y="days", color=COLORS["cyan"], width=0.58, fliersize=1.2, ax=ax) + ax.axhline(90, color=COLORS["red"], ls="--", lw=1) + ax.set_xlabel("") + ax.set_ylabel("Absolute offset (days)") + ax.set_ylim(-2, 95) + + ax = axes[1, 1] + panel(ax, "D", "Calendar drift in baseline stiffness prevalence") + yearly = index.groupby(index.scan_date.dt.year).agg(n=("advanced", "size"), advanced=("advanced", "mean"), high_cap=("cap280", "mean"), retention=("retention", "mean")).reset_index(names="year") + ax.plot(yearly.year, 100 * yearly.advanced, marker="o", color=COLORS["red"], label="LSM >=9.5") + ax.plot(yearly.year, 100 * yearly.high_cap, marker="s", color=COLORS["gold"], label="CAP >=280") + ax.plot(yearly.year, 100 * yearly.retention, marker="^", color=COLORS["purple"], label="Low-CAP/high-LSM") + for row in yearly.itertuples(): + ax.text(row.year, 100 * row.high_cap + 2.2, f"n={row.n:,}", ha="center", fontsize=6.5) + ax.set_xticks(yearly.year) + ax.set_ylabel("Index patients (%)") + ax.set_xlabel("Year") + ax.set_ylim(0, 58) + ax.legend(frameon=False, ncol=3, loc="upper left") + + fig.suptitle("Extended Data Figure 1 | Clinical data quality, linkage, and calendar structure", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_1") + + +def forest_effect_panel(ax: plt.Axes, data: pd.DataFrame, title: str, endpoint: str, color: str) -> None: + panel(ax, title[0], title[2:]) + d = data.loc[data.endpoint == endpoint].sort_values("beta_per_SD") + y = np.arange(len(d)) + ax.errorbar(d.beta_per_SD, y, xerr=[d.beta_per_SD - d.ci_low, d.ci_high - d.beta_per_SD], fmt="o", color=color, ecolor=color, capsize=2.5, ms=4.5) + ax.axvline(0, color=COLORS["gray"], ls="--", lw=0.9) + n_col = "n" if "n" in d.columns else "n_keys" + labels = [f"{a} n={int(n)}" for a, n in zip(d.analyte, d[n_col])] + ax.set_yticks(y, labels) + ax.set_xlabel("Adjusted effect per 1-SD analyte") + for yi, row in enumerate(d.itertuples()): + if row.q_value_BH < 0.05: + ax.text(row.ci_high, yi + 0.18, f"q={row.q_value_BH:.2g}", fontsize=6, color=color, ha="right") + + +def figure_ed2() -> None: + metabolic = pd.read_csv(CLIN / "metabolic_models.tsv", sep="\t") + lis = pd.read_csv(CLIN / "lis_models.tsv", sep="\t") + keep_met = metabolic.loc[(metabolic.q_value_BH < 0.10) | metabolic.analyte.isin(["TG", "HDL", "UA", "FPG"])].copy() + keep_lis = lis.loc[(lis.q_value_BH < 0.10) | lis.analyte.isin(["AST", "ALT", "GGT", "HA", "LN", "CIV", "PIIINP", "ALB", "PLT"])].copy() + fig, axes = plt.subplots(2, 2, figsize=(13.5, 10.3), gridspec_kw={"hspace": 0.48, "wspace": 0.42}) + forest_effect_panel(axes[0, 0], keep_met, "A Metabolic markers -> CAP", "CAP_dB_per_m", COLORS["gold"]) + forest_effect_panel(axes[0, 1], keep_met, "B Metabolic markers -> log-LSM", "log_LSM", COLORS["orange"]) + forest_effect_panel(axes[1, 0], keep_lis, "C LIS markers -> CAP", "CAP_dB_per_m", COLORS["blue"]) + forest_effect_panel(axes[1, 1], keep_lis, "D LIS markers -> log-LSM", "log_LSM", COLORS["red"]) + fig.suptitle("Extended Data Figure 2 | Adjusted metabolic and laboratory associations with CAP and LSM", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_2") + + +def figure_ed3(index_matched: pd.DataFrame) -> None: + fast = pd.read_csv(CLIN / "fast_score.tsv", sep="\t") + perf = pd.read_csv(CLIN / "fib4_ecm_performance.tsv", sep="\t") + cal = pd.read_csv(CLIN / "fib4_ecm_calibration.tsv", sep="\t") + fig, axes = plt.subplots(2, 2, figsize=(13.5, 9.6), gridspec_kw={"hspace": 0.52, "wspace": 0.42}) + + ax = axes[0, 0] + panel(ax, "A", "FAST distribution in CAP >=248 screening context") + d = fast.loc[fast.CAP_steatotic_phenotype] + ax.hist(d.FAST, bins=np.linspace(0, 1, 31), color=COLORS["teal"], edgecolor="white") + ax.axvline(0.35, color=COLORS["gold"], ls="--", lw=1.2) + ax.axvline(0.67, color=COLORS["red"], ls="--", lw=1.2) + ax.set_xlabel("FAST score") + ax.set_ylabel("Patients") + ax.text(0.03, 0.94, "n=286", transform=ax.transAxes, va="top", fontweight="bold") + + ax = axes[0, 1] + panel(ax, "B", "FAST varies across CAP-LSM states (descriptive)") + d = fast.copy() + d["state"] = state_code(d.CAP, d.LSM) + sns.boxplot(data=d, x="state", y="FAST", order=["LL", "HL", "LH", "HH"], palette=STATE_COLORS, width=0.62, fliersize=1.5, ax=ax) + ax.set_xlabel("CAP-LSM state") + ax.set_ylabel("FAST") + + ax = axes[1, 0] + panel(ax, "C", "Observed advanced-LSM fraction across score quartiles") + for score, color, marker in [("FIB4", COLORS["blue"], "o"), ("ECM4", COLORS["red"], "s")]: + q = cal.loc[cal.score == score].reset_index(drop=True) + x = np.arange(1, 5) + observed = q["observed_fraction_LSM_ge9.5"] + ax.errorbar(x, 100 * observed, yerr=[100 * (observed - q.ci_low), 100 * (q.ci_high - observed)], marker=marker, color=color, capsize=3, label=score) + ax.set_xticks([1, 2, 3, 4], ["Q1", "Q2", "Q3", "Q4"]) + ax.set_xlabel("Score quartile") + ax.set_ylabel("LSM >=9.5 kPa (%)") + ax.set_ylim(0, 85) + ax.legend(frameon=False) + + ax = axes[1, 1] + panel(ax, "D", "Imaging-reference discrimination remains imprecise") + auc = perf.loc[perf.metric == "AUROC_vs_LSM_ge9.5"].copy().iloc[::-1] + y = np.arange(len(auc)) + ax.errorbar(auc.estimate, y, xerr=[auc.estimate - auc.ci_low, auc.ci_high - auc.estimate], fmt="o", color=COLORS["blue"], capsize=3) + ax.axvline(0.5, color=COLORS["gray"], ls="--", lw=1) + ax.set_yticks(y, [f"{a} n={int(n)}" for a, n in zip(auc.analysis, auc.n)]) + ax.set_xlim(0.42, 1.0) + ax.set_xlabel("AUROC vs LSM >=9.5") + ax.text(0, -0.24, "FAST is not independently validated here because LSM and CAP are components of FAST.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + fig.suptitle("Extended Data Figure 3 | FAST, FIB-4, and ECM4 clinical calibration", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_3") + + +def figure_ed4() -> None: + sens = pd.read_csv(DYN / "S5_clinical_history_gain/threshold_sensitivity.tsv", sep="\t") + trans = pd.read_csv(DYN / "S3_clinical_multistate/transition_matrix.tsv", sep="\t") + curves = pd.read_csv(DYN / "S3_clinical_multistate/branch_prediction_curves.tsv", sep="\t") + branch = pd.read_csv(DYN / "S3_clinical_multistate/branch_model_summary.tsv", sep="\t") + fig, axes = plt.subplots(2, 2, figsize=(13.5, 9.6), gridspec_kw={"hspace": 0.52, "wspace": 0.40}) + + ax = axes[0, 0] + panel(ax, "A", "History-gain threshold landscape") + piv = sens.pivot(index="lsm_cut", columns="cap_cut", values="log_loss_gain").sort_index(ascending=False) + sns.heatmap(piv, cmap="RdBu_r", center=0, annot=True, fmt=".3f", linewidths=1, linecolor="white", cbar_kws={"label": "Held-out log-loss gain"}, ax=ax) + ax.set_xlabel("CAP threshold (dB/m)") + ax.set_ylabel("LSM threshold (kPa)") + cap_cols = list(piv.columns) + lsm_rows = list(piv.index) + if 280 in cap_cols and 9.5 in lsm_rows: + ax.add_patch(Rectangle((cap_cols.index(280), lsm_rows.index(9.5)), 1, 1, fill=False, ec=COLORS["dark"], lw=2.2)) + + ax = axes[0, 1] + panel(ax, "B", "Prespecified and exploratory uncertainty") + d = sens.loc[((sens.cap_cut == 280) & (sens.lsm_cut == 9.5)) | ((sens.lsm_cut == 12.0) & sens.log_loss_gain_ci_low.notna())].copy() + d["label"] = np.where(d.lsm_cut == 9.5, "Prespecified CAP280 / LSM9.5", "Exploratory CAP" + d.cap_cut.astype(int).astype(str) + " / LSM12") + d = d.sort_values(["lsm_cut", "cap_cut"]) + y = np.arange(len(d))[::-1] + for yi, row in zip(y, d.itertuples()): + color = COLORS["red"] if row.lsm_cut == 9.5 else COLORS["blue"] + ax.errorbar(row.log_loss_gain, yi, xerr=[[row.log_loss_gain - row.log_loss_gain_ci_low], [row.log_loss_gain_ci_high - row.log_loss_gain]], fmt="o", color=color, capsize=3) + ax.text(row.log_loss_gain_ci_high + 0.004, yi, f"Pperm={row.history_permutation_p:.3f}", va="center", fontsize=6.5) + ax.axvline(0, color=COLORS["gray"], ls="--", lw=1) + ax.set_yticks(y, d.label) + ax.set_xlabel("History-model log-loss gain") + ax.text(0, -0.23, "LSM12 results follow a 15-threshold search and remain hypothesis-generating.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + ax = axes[1, 0] + panel(ax, "C", "Four-state transition probabilities at >=90 days") + t = trans.loc[trans.min_interval_days == 90].pivot(index="from_state", columns="to_state", values="row_probability") + order = ["LL", "HL", "LH", "HH"] + t = t.reindex(index=order, columns=order) + sns.heatmap(100 * t, cmap="YlGnBu", annot=True, fmt=".1f", linewidths=1, linecolor="white", cbar_kws={"label": "Row probability (%)"}, ax=ax) + ax.set_xlabel("Next state") + ax.set_ylabel("Current state") + + ax = axes[1, 1] + panel(ax, "D", "Primary and lag-adjusted CAP-LSM branches") + for model, ls in [("branch_primary", "-"), ("branch_lag_adjusted", "--")]: + for direction, color in [("up", COLORS["red"]), ("down", COLORS["blue"] )]: + d = curves.loc[(curves.model == model) & (curves.direction == direction)].sort_values("CAP") + ax.plot(d.CAP, d.pred_LSM, color=color, ls=ls, lw=1.5, label=f"{model.replace('branch_', '')}: CAP {direction}") + ax.fill_between(d.CAP, d.ci_low, d.ci_high, color=color, alpha=0.08) + ax.set_xlabel("CAP (dB/m)") + ax.set_ylabel("Predicted LSM (kPa)") + ax.legend(frameon=False, fontsize=6.4, ncol=2) + txt = " | ".join([f"{r.model.replace('branch_', '')}: joint P={r.joint_direction_p:.3g}" for r in branch.itertuples()]) + ax.text(0, -0.23, txt, transform=ax.transAxes, fontsize=6.6, color=COLORS["gray"]) + + fig.suptitle("Extended Data Figure 4 | Multistate dynamics, threshold sensitivity, and branch asymmetry", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_4") + + +def figure_ed5(index: pd.DataFrame, longitudinal: pd.DataFrame) -> None: + fig, axes = plt.subplots(2, 2, figsize=(13.5, 9.5), gridspec_kw={"hspace": 0.52, "wspace": 0.40}) + ax = axes[0, 0] + panel(ax, "A", "Follow-up interval distribution") + ax.hist(longitudinal.followup_days, bins=35, color=COLORS["blue"], edgecolor="white") + ax.axvline(longitudinal.followup_days.median(), color=COLORS["red"], ls="--", lw=1.2) + ax.set_xlabel("First-to-last interval (days)") + ax.set_ylabel("Patients") + ax.text(0.98, 0.94, f"median {longitudinal.followup_days.median():.0f} days\nn={len(longitudinal):,}", transform=ax.transAxes, ha="right", va="top", fontsize=7) + + ax = axes[0, 1] + panel(ax, "B", "Baseline versus final LSM") + ax.scatter(longitudinal.LSM0, longitudinal.LSM1, s=8, alpha=0.30, color=COLORS["blue"], edgecolor="none") + lim = [2.5, 33] + ax.plot(lim, lim, color=COLORS["gray"], ls="--", lw=1) + ax.axvline(9.5, color=COLORS["red"], ls=":", lw=1) + ax.axhline(9.5, color=COLORS["red"], ls=":", lw=1) + ax.set_xlim(lim) + ax.set_ylim(lim) + ax.set_xlabel("Baseline LSM (kPa)") + ax.set_ylabel("Final LSM (kPa)") + + ax = axes[1, 0] + panel(ax, "C", "Relative LSM change by baseline state") + sns.violinplot(data=longitudinal, x="state0", y="relative_LSM", order=["LL", "HL", "LH", "HH"], palette=STATE_COLORS, inner="quartile", cut=0, linewidth=0.8, ax=ax) + ax.axhline(0, color=COLORS["gray"], lw=0.8) + ax.axhline(-0.2, color=COLORS["blue"], ls="--", lw=0.9) + ax.axhline(0.2, color=COLORS["red"], ls="--", lw=0.9) + ax.set_ylim(-1.0, 2.5) + ax.set_xlabel("Baseline CAP-LSM state") + ax.set_ylabel("Relative LSM change") + + ax = axes[1, 1] + panel(ax, "D", "Longitudinal outcomes by baseline era") + tab = pd.crosstab(longitudinal.baseline_era, longitudinal.outcome).reindex(columns=["Persistent nonadvanced", "Threshold regression", "Persistent advanced", "Threshold progression"], fill_value=0) + pct = tab.div(tab.sum(axis=1), axis=0) * 100 + bottom = np.zeros(len(pct)) + colors = [COLORS["teal"], COLORS["blue"], COLORS["red"], COLORS["orange"]] + for col, color in zip(pct.columns, colors): + ax.bar(pct.index, pct[col], bottom=bottom, color=color, label=col, width=0.58, edgecolor="white") + bottom += pct[col].to_numpy() + for i, era in enumerate(pct.index): + ax.text(i, 102, f"n={tab.loc[era].sum():,}", ha="center", fontsize=6.8) + ax.set_ylim(0, 109) + ax.set_ylabel("Patients (%)") + ax.legend(frameon=False, fontsize=6.3, loc="lower center", bbox_to_anchor=(0.5, -0.32), ncol=2) + + fig.suptitle("Extended Data Figure 5 | Longitudinal distributions and temporal robustness", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_5") + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--clinical-input-dir", type=Path, default=CLIN) + parser.add_argument("--dynamics-input-dir", type=Path, default=DYN) + parser.add_argument("--output-dir", type=Path, default=OUTPUT_ROOT) + return parser.parse_args() + + +def main() -> None: + global CLIN, DYN, OUTPUT_ROOT, TABLES, MAIN, ED, LOGS + args = parse_args() + CLIN, DYN, OUTPUT_ROOT = args.clinical_input_dir, args.dynamics_input_dir, args.output_dir + TABLES = OUTPUT_ROOT / "source_tables" + MAIN = OUTPUT_ROOT / "main_figures" + ED = OUTPUT_ROOT / "extended_data_figures" + LOGS = OUTPUT_ROOT / "logs" + for folder in [TABLES, MAIN, ED, LOGS]: + folder.mkdir(parents=True, exist_ok=True) + elasto = pd.read_parquet(CLIN / "elasto_clean_full.parquet") + elasto = elasto.loc[elasto.adult_at_scan].copy().sort_values(["medical_record_hash", "scan_timestamp"]) + index = elasto.groupby("medical_record_hash", as_index=False).first() + index["male"] = index.sex.eq("M") + index["advanced"] = index.advanced_fibrosis_lsm_ge9_5.astype(bool) + index["cap248"] = index.CAP.ge(248) + index["cap280"] = index.CAP.ge(280) + index["f3"] = index.fibrosis_stage.eq("F3") + index["f4"] = index.fibrosis_stage.eq("F4") + index["gi"] = index.department.fillna("").str.contains("消化|肝胆") + index["state"] = state_code(index.CAP, index.LSM) + index["retention"] = index.state.eq("LH") + + matched = pd.read_parquet(CLIN / "matched_90d.parquet") + matched_index = index[["scan_hash"]].merge(matched, on="scan_hash", how="left", suffixes=("", "_matched")) + etiology = pd.read_csv(CLIN / "etiology_summary.tsv", sep="\t") + score = pd.read_csv(CLIN / "serum_decodable_state_score.tsv", sep="\t") + + baseline = baseline_table(index) + validation = validation_analysis(index) + longitudinal = build_longitudinal(elasto) + serum_or = serum_associations(score) + + baseline.to_csv(TABLES / "Table1_baseline_8142.tsv", sep="\t", index=False) + validation.to_csv(TABLES / "clinical_validation_metrics.tsv", sep="\t", index=False) + pd.crosstab(longitudinal.state0, longitudinal.state1).to_csv(TABLES / "longitudinal_state_flow.tsv", sep="\t") + longitudinal.outcome.value_counts().rename_axis("outcome").reset_index(name="n").to_csv(TABLES / "longitudinal_outcomes.tsv", sep="\t", index=False) + serum_or.to_csv(TABLES / "serum_imbalance_associations.tsv", sep="\t", index=False) + + summary = { + "cohort": { + "raw_scans": 9703, + "technical_qc_scans": 9644, + "adult_qc_scans": int(len(elasto)), + "adult_index_patients": int(len(index)), + "advanced_lsm_n": int(index.advanced.sum()), + "advanced_lsm_fraction": float(index.advanced.mean()), + "retention_phenotype_n": int(index.retention.sum()), + }, + "longitudinal": { + "n": int(len(longitudinal)), + "median_followup_days": float(longitudinal.followup_days.median()), + "outcomes": {k: int(v) for k, v in longitudinal.outcome.value_counts().items()}, + "regression_resistant_n": int(longitudinal.regression_resistant.sum()), + }, + "ethics": "approval number, approval date, committee, and consent-waiver status pending author input", + "clinical_event_boundary": "readmission, decompensation, mortality, transplant, treatment exposure, and prescription outcomes not present in current source files", + } + (TABLES / "clinical_analysis_summary.json").write_text(json.dumps(summary, ensure_ascii=False, indent=2), encoding="utf-8") + + figure_main_1(index, baseline, etiology, validation) + figure_main_2(longitudinal, score, serum_or) + figure_ed1(index, matched_index) + figure_ed2() + figure_ed3(matched_index) + figure_ed4() + figure_ed5(index, longitudinal) + + log = { + "script": str(SCRIPT), + "inputs": {"clinical": str(CLIN), "dynamics": str(DYN)}, + "main_figures": sorted(str(p) for p in MAIN.glob("*.png")), + "extended_figures": sorted(str(p) for p in ED.glob("*.png")), + "tables": sorted(str(p) for p in TABLES.glob("*")), + } + (LOGS / "rebuild_clinical_visuals_manifest.json").write_text(json.dumps(log, ensure_ascii=False, indent=2), encoding="utf-8") + print(json.dumps(summary, ensure_ascii=False, indent=2)) + + +if __name__ == "__main__": + main() diff --git a/code/codex/UQ_CODEX_spatial_protein_validation.py b/code/codex/UQ_CODEX_spatial_protein_validation.py new file mode 100644 index 0000000..ab52513 --- /dev/null +++ b/code/codex/UQ_CODEX_spatial_protein_validation.py @@ -0,0 +1,378 @@ +#!/usr/bin/env python3 +"""Quantify CODEX protein organization around Collagen-IV-rich MASLD scar fields.""" + +from __future__ import annotations + +import argparse +import re +from pathlib import Path + +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +import seaborn as sns +import tifffile +from scipy.spatial import cKDTree +from skimage import measure, morphology +from skimage.filters import gaussian + + +SAMPLES = { + "17P29186": {"fibrosis_stage": "F1", "stage_numeric": 1}, + "16P15496": {"fibrosis_stage": "F2", "stage_numeric": 2}, + "16P33251": {"fibrosis_stage": "F4", "stage_numeric": 4}, +} +MARKERS = ["DAPI", "CD44", "Vimentin", "CD14", "CD31", "PANCK", "CD163", "CollagenIV"] +OUTCOMES = ["Vimentin", "CD31", "CD163", "CD14", "CD44", "mesenchymal_endothelial_balance"] +COLORS = { + "Vimentin": "#B24C63", + "CD31": "#2789A7", + "CD163": "#6B8E23", + "CD14": "#B07B2A", + "CD44": "#76528B", + "mesenchymal_endothelial_balance": "#7A1F3D", +} + + +def tag(description: str, name: str) -> str: + match = re.search(fr"<{name}>(.*?)", description, flags=re.S) + return match.group(1).strip() if match else "" + + +def channel_metadata(path: Path) -> pd.DataFrame: + rows = [] + with tifffile.TiffFile(path) as handle: + for index, page in enumerate(handle.series[0].pages): + description = page.description or "" + rows.append( + { + "channel_index": index, + "name": tag(description, "Name"), + "biomarker": tag(description, "Biomarker"), + "exposure_time": tag(description, "ExposureTime"), + "signal_units": tag(description, "SignalUnits"), + } + ) + return pd.DataFrame(rows) + + +def largest_tissue_mask(dapi: np.ndarray, vimentin: np.ndarray, panck: np.ndarray) -> np.ndarray: + base = np.maximum.reduce([dapi.astype(float), 0.25 * vimentin, 0.25 * panck]) + mask = gaussian(base, sigma=2, preserve_range=True) > 1.0 + mask = morphology.closing(mask, morphology.disk(3)) + labels = measure.label(mask) + if labels.max() == 0: + raise RuntimeError("No tissue component detected") + counts = np.bincount(labels.ravel()) + counts[0] = 0 + return labels == counts.argmax() + + +def block_sum(values: np.ndarray, size: int) -> np.ndarray: + rows = values.shape[0] // size + columns = values.shape[1] // size + cropped = values[: rows * size, : columns * size] + return cropped.reshape(rows, size, columns, size).sum(axis=(1, 3)) + + +def winsorized_z(values: np.ndarray) -> np.ndarray: + low, high = np.nanpercentile(values, [1, 99]) + clipped = np.clip(values, low, high) + return (clipped - np.nanmean(clipped)) / max(np.nanstd(clipped, ddof=1), 1e-8) + + +def patch_table(images: dict[str, np.ndarray], mask: np.ndarray, patch_size: int) -> tuple[pd.DataFrame, tuple[int, int]]: + denominator = block_sum(mask.astype(float), patch_size) + coverage = denominator / (patch_size**2) + valid = coverage >= 0.15 + row_index, column_index = np.indices(coverage.shape) + table = pd.DataFrame( + { + "patch_row": row_index[valid], + "patch_col": column_index[valid], + "tissue_coverage": coverage[valid], + } + ) + for marker, image in images.items(): + mean = block_sum(image.astype(float) * mask, patch_size) / np.maximum(denominator, 1) + table[marker] = mean[valid] + table[f"z_{marker}"] = winsorized_z(mean[valid]) + table["mesenchymal_endothelial_balance"] = table["z_Vimentin"] - table["z_CD31"] + table["scar_patch"] = table["z_CollagenIV"].ge(table["z_CollagenIV"].quantile(0.80)) + return table, coverage.shape + + +def nearest_fill(grid: np.ndarray) -> np.ndarray: + result = grid.copy() + missing = np.argwhere(~np.isfinite(result)) + valid = np.argwhere(np.isfinite(result)) + if len(missing): + tree = cKDTree(valid) + _, nearest = tree.query(missing, k=1) + result[missing[:, 0], missing[:, 1]] = result[valid[nearest, 0], valid[nearest, 1]] + return result + + +def rectangular_transforms(rows: int, columns: int) -> list[np.ndarray]: + grid = np.arange(rows * columns).reshape(rows, columns) + forms = [grid, np.flipud(grid), np.fliplr(grid), np.flipud(np.fliplr(grid))] + identity = tuple(grid.ravel()) + unique: dict[tuple[int, ...], np.ndarray] = {} + for form in forms: + for dy in range(rows): + for dx in range(columns): + index = np.roll(np.roll(form, dy, axis=0), dx, axis=1).ravel() + key = tuple(map(int, index)) + if key != identity: + unique[key] = index + return list(unique.values()) + + +def toroidal_moran(grid: np.ndarray) -> float: + centered = grid - grid.mean() + lag = ( + np.roll(centered, 1, 0) + + np.roll(centered, -1, 0) + + np.roll(centered, 1, 1) + + np.roll(centered, -1, 1) + ) + denominator = np.sum(centered**2) + return float(np.sum(centered * lag) / (4 * denominator)) if denominator else np.nan + + +def fit_spatial_null(table: pd.DataFrame, outcome: str, shape: tuple[int, int]) -> dict[str, float]: + y = table[outcome].to_numpy(float) if outcome == "mesenchymal_endothelial_balance" else table[f"z_{outcome}"].to_numpy(float) + collagen = table["z_CollagenIV"].to_numpy(float) + nuisance = np.column_stack( + [np.ones(len(table)), table["z_DAPI"].to_numpy(float), table["tissue_coverage"].to_numpy(float)] + ) + full = np.column_stack([nuisance, collagen]) + coefficients = np.linalg.lstsq(full, y, rcond=None)[0] + beta = float(coefficients[-1]) + residual = y - full @ coefficients + dof = max(len(y) - full.shape[1], 1) + sigma2 = float(residual @ residual / dof) + covariance = sigma2 * np.linalg.pinv(full.T @ full) + se = float(np.sqrt(max(covariance[-1, -1], 0))) + + nuisance_coefficients = np.linalg.lstsq(nuisance, y, rcond=None)[0] + fitted = nuisance @ nuisance_coefficients + field = y - fitted + rows, columns = shape + position = table["patch_row"].to_numpy(int) * columns + table["patch_col"].to_numpy(int) + grid = np.full(shape, np.nan) + grid.ravel()[position] = field + grid = nearest_fill(grid) + transforms = rectangular_transforms(*shape) + null = np.empty(len(transforms)) + moran = np.empty(len(transforms)) + for i, index in enumerate(transforms): + transformed = grid.ravel()[index][position] + null[i] = np.linalg.lstsq(full, fitted + transformed, rcond=None)[0][-1] + moran[i] = toroidal_moran(grid.ravel()[index].reshape(shape)) + p = float((1 + np.sum(np.abs(null) >= abs(beta))) / (len(null) + 1)) + return { + "outcome": outcome, + "collagen_coupling_beta": beta, + "beta_se": se, + "beta_ci_low": beta - 1.96 * se, + "beta_ci_high": beta + 1.96 * se, + "spatial_field_p": p, + "n_spatial_transforms": len(transforms), + "residual_moran": toroidal_moran(grid), + "permuted_moran_min": float(np.min(moran)), + "permuted_moran_max": float(np.max(moran)), + } + + +def normalized_channel(image: np.ndarray) -> np.ndarray: + positive = image[image > 0] + high = np.percentile(positive, 99.7) if len(positive) else 1 + return np.clip(image.astype(float) / max(high, 1), 0, 1) + + +def preview_composite(images: dict[str, np.ndarray]) -> np.ndarray: + dapi = normalized_channel(images["DAPI"]) + vimentin = normalized_channel(images["Vimentin"]) + cd31 = normalized_channel(images["CD31"]) + cd163 = normalized_channel(images["CD163"]) + collagen = normalized_channel(images["CollagenIV"]) + return np.stack( + [np.clip(0.75 * vimentin + 0.35 * cd163 + 0.18 * dapi, 0, 1), + np.clip(0.75 * cd31 + 0.15 * dapi, 0, 1), + np.clip(0.90 * collagen + 0.30 * dapi, 0, 1)], + axis=-1, + ) + + +def crop_to_mask(image: np.ndarray, mask: np.ndarray, margin: int = 8) -> np.ndarray: + rows, columns = np.where(mask) + y0, y1 = max(rows.min() - margin, 0), min(rows.max() + margin + 1, image.shape[0]) + x0, x1 = max(columns.min() - margin, 0), min(columns.max() + margin + 1, image.shape[1]) + return image[y0:y1, x0:x1] + + +def plot_results( + previews: dict[str, np.ndarray], + patch_scores: pd.DataFrame, + coupling: pd.DataFrame, + enrichment: pd.DataFrame, + output: Path, +) -> None: + sns.set_theme(style="ticks", context="paper") + ordered = sorted(SAMPLES, key=lambda sample: SAMPLES[sample]["stage_numeric"]) + fig = plt.figure(figsize=(15, 10.5), constrained_layout=True) + grid = fig.add_gridspec(3, 3, height_ratios=[0.85, 0.75, 1.0]) + + for column, sample in enumerate(ordered): + ax = fig.add_subplot(grid[0, column]) + ax.imshow(previews[sample]) + ax.set_axis_off() + ax.set_title(f"{SAMPLES[sample]['fibrosis_stage']} | {sample}", fontweight="bold") + if column == 0: + ax.text(-0.08, 1.05, "A", transform=ax.transAxes, fontsize=15, fontweight="bold") + + for column, sample in enumerate(ordered): + ax = fig.add_subplot(grid[1, column]) + local = patch_scores.loc[patch_scores["sample"].eq(sample)] + shape = (int(local["grid_rows"].iat[0]), int(local["grid_columns"].iat[0])) + image = np.full(shape, np.nan) + image[local["patch_row"].to_numpy(int), local["patch_col"].to_numpy(int)] = local["mesenchymal_endothelial_balance"] + artist = ax.imshow(image, cmap="RdBu_r", vmin=-3, vmax=3, aspect="auto", interpolation="nearest") + ax.set_axis_off() + ax.set_title("Vimentin - CD31 balance", fontsize=9) + if column == 0: + ax.text(-0.08, 1.05, "B", transform=ax.transAxes, fontsize=15, fontweight="bold") + colorbar = fig.colorbar(artist, ax=fig.axes[3:6], shrink=0.78, pad=0.01) + colorbar.set_label("Winsorized z-score difference") + + ax = fig.add_subplot(grid[2, 0]) + show = ["Vimentin", "CD31", "CD163", "mesenchymal_endothelial_balance"] + for outcome in ["Vimentin", "CD31", "CD163"]: + local = coupling.loc[coupling["outcome"].eq(outcome)].sort_values("stage_numeric") + ax.plot(local["stage_numeric"], local["collagen_coupling_beta"], marker="o", lw=2, color=COLORS[outcome], label=outcome.replace("_", " ")) + ax.axhline(0, color="#777777", lw=0.8) + ax.set_xticks([1, 2, 4], ["F1", "F2", "F4"]) + ax.set_xlabel("Fibrosis stage") + ax.set_ylabel("Collagen-IV coupling beta") + ax.set_title("C Protein coupling at the scar field", loc="left", fontweight="bold") + ax.legend(frameon=False, fontsize=7) + + ax = fig.add_subplot(grid[2, 1]) + local = enrichment.loc[enrichment["outcome"].isin(show)].copy() + sns.barplot(data=local, x="fibrosis_stage", y="scar_enrichment", hue="outcome", hue_order=show, palette=COLORS, ax=ax) + ax.axhline(0, color="#777777", lw=0.8) + ax.set_xlabel("Fibrosis stage") + ax.set_ylabel("Top-scar minus non-scar z-score") + ax.set_title("D Enrichment in top 20% scar patches", loc="left", fontweight="bold") + ax.legend(frameon=False, fontsize=7) + + ax = fig.add_subplot(grid[2, 2]) + heat = enrichment.pivot(index="outcome", columns="fibrosis_stage", values="scar_enrichment") + heat = heat.reindex(show)[["F1", "F2", "F4"]] + sns.heatmap(heat, cmap="vlag", center=0, annot=True, fmt=".2f", cbar_kws={"label": "Scar-patch enrichment"}, ax=ax) + ax.set_xlabel("") + ax.set_ylabel("") + ax.set_title("E Scar-patch compositional shift", loc="left", fontweight="bold") + + for axis in fig.axes: + if hasattr(axis, "spines"): + axis.spines[["top", "right"]].set_visible(False) + fig.suptitle("CODEX supports progressive mesenchymal occupation of Collagen-IV-rich scar fields", fontsize=15, fontweight="bold") + fig.savefig(output.with_suffix(".png"), dpi=350, bbox_inches="tight", facecolor="white") + fig.savefig(output.with_suffix(".pdf"), bbox_inches="tight", facecolor="white") + plt.close(fig) + + +def main() -> None: + parser = argparse.ArgumentParser() + parser.add_argument("--codex-root", type=Path, required=True) + parser.add_argument("--results-dir", type=Path, required=True) + parser.add_argument("--figures-dir", type=Path, required=True) + parser.add_argument("--level", type=int, default=2) + parser.add_argument("--patch-size", type=int, default=128) + args = parser.parse_args() + args.results_dir.mkdir(parents=True, exist_ok=True) + args.figures_dir.mkdir(parents=True, exist_ok=True) + + patch_frames = [] + coupling_rows = [] + enrichment_rows = [] + sensitivity_coupling_rows = [] + sensitivity_enrichment_rows = [] + metadata_frames = [] + previews: dict[str, np.ndarray] = {} + + for sample, sample_metadata in SAMPLES.items(): + path = next((args.codex_root / sample).glob("*.qptiff")) + channels = channel_metadata(path) + channels.insert(0, "sample", sample) + metadata_frames.append(channels) + lookup = dict(zip(channels["biomarker"], channels["channel_index"], strict=True)) + indices = [lookup[marker] for marker in MARKERS] + with tifffile.TiffFile(path) as handle: + array = handle.series[0].levels[args.level].asarray(key=indices) + preview_array = handle.series[0].levels[min(args.level + 1, len(handle.series[0].levels) - 1)].asarray(key=indices) + images = {marker: image for marker, image in zip(MARKERS, array, strict=True)} + preview_images = {marker: image for marker, image in zip(MARKERS, preview_array, strict=True)} + mask = largest_tissue_mask(images["DAPI"], images["Vimentin"], images["PANCK"]) + preview_mask = largest_tissue_mask(preview_images["DAPI"], preview_images["Vimentin"], preview_images["PANCK"]) + previews[sample] = crop_to_mask(preview_composite(preview_images), preview_mask) + + sensitivity_sizes = sorted(set([96, args.patch_size, 160])) + for patch_size in sensitivity_sizes: + patches, shape = patch_table(images, mask, patch_size) + patches.insert(0, "sample", sample) + patches["fibrosis_stage"] = sample_metadata["fibrosis_stage"] + patches["stage_numeric"] = sample_metadata["stage_numeric"] + patches["grid_rows"] = shape[0] + patches["grid_columns"] = shape[1] + patches["patch_size"] = patch_size + if patch_size == args.patch_size: + patch_frames.append(patches) + + for outcome in OUTCOMES: + result = fit_spatial_null(patches, outcome, shape) + coupling_record = { + "sample": sample, + **sample_metadata, + "patch_size": patch_size, + "n_patches": len(patches), + **result, + } + sensitivity_coupling_rows.append(coupling_record) + if patch_size == args.patch_size: + coupling_rows.append(coupling_record) + values = patches[outcome] if outcome == "mesenchymal_endothelial_balance" else patches[f"z_{outcome}"] + enrichment_record = { + "sample": sample, + **sample_metadata, + "patch_size": patch_size, + "outcome": outcome, + "scar_enrichment": float(values[patches["scar_patch"]].mean() - values[~patches["scar_patch"]].mean()), + } + sensitivity_enrichment_rows.append(enrichment_record) + if patch_size == args.patch_size: + enrichment_rows.append(enrichment_record) + + patch_scores = pd.concat(patch_frames, ignore_index=True) + coupling = pd.DataFrame(coupling_rows) + enrichment = pd.DataFrame(enrichment_rows) + channel_table = pd.concat(metadata_frames, ignore_index=True) + patch_scores.to_parquet(args.results_dir / "UQ_CODEX_patch_scores.parquet", index=False) + coupling.to_csv(args.results_dir / "UQ_CODEX_spatial_coupling.tsv", sep="\t", index=False) + enrichment.to_csv(args.results_dir / "UQ_CODEX_scar_enrichment.tsv", sep="\t", index=False) + pd.DataFrame(sensitivity_coupling_rows).to_csv( + args.results_dir / "UQ_CODEX_patch_size_sensitivity_coupling.tsv", sep="\t", index=False + ) + pd.DataFrame(sensitivity_enrichment_rows).to_csv( + args.results_dir / "UQ_CODEX_patch_size_sensitivity_enrichment.tsv", sep="\t", index=False + ) + channel_table.to_csv(args.results_dir / "UQ_CODEX_channel_metadata.tsv", sep="\t", index=False) + plot_results(previews, patch_scores, coupling, enrichment, args.figures_dir / "Figure_UQ_CODEX_spatial_protein_validation") + print("\nSPATIAL COUPLING\n", coupling.to_string(index=False)) + print("\nSCAR ENRICHMENT\n", enrichment.to_string(index=False)) + + +if __name__ == "__main__": + main() diff --git a/code/figures/build_mechanism_circuit.py b/code/figures/build_mechanism_circuit.py new file mode 100644 index 0000000..4dec89a --- /dev/null +++ b/code/figures/build_mechanism_circuit.py @@ -0,0 +1,222 @@ +#!/usr/bin/env python3 +"""Build an evidence-coded candidate circuit for HSC retention and scar persistence.""" + +from __future__ import annotations + +import argparse +from pathlib import Path + +import matplotlib as mpl +import matplotlib.pyplot as plt +from matplotlib.patches import FancyArrowPatch, FancyBboxPatch, Patch +import pandas as pd + + +REPO_ROOT = Path(__file__).resolve().parents[2] +DEFAULT_EDGES = REPO_ROOT / "data/mechanism_summary/mechanism_edge_evidence.tsv" +DEFAULT_OUTPUT = REPO_ROOT / "figures/source_panels/Fig7A_Evidence_Coded_Mechanism" + +NODE_STYLE = { + "resolver": {"face": "#E8F5F5", "edge": "#258B92", "text": "#165F65"}, + "proteolysis": {"face": "#EEF7F3", "edge": "#4A9A79", "text": "#286A51"}, + "retention": {"face": "#FBEDEF", "edge": "#BF4960", "text": "#873146"}, + "mechanical": {"face": "#F2EEF7", "edge": "#76648E", "text": "#534366"}, + "matrix": {"face": "#F4F2F1", "edge": "#6C6A68", "text": "#42413F"}, +} + +EDGE_STYLE = { + "literature-established": {"color": "#4D565C", "linestyle": "-", "linewidth": 1.45}, + "project-supported association": {"color": "#B43E58", "linestyle": "--", "linewidth": 1.55}, + "testable candidate edge": {"color": "#C58B22", "linestyle": ":", "linewidth": 1.8}, +} + +NODES = { + "WNT9B+ endothelium": (0.08, 0.80, "resolver"), + "HSC deactivation": (0.28, 0.80, "resolver"), + "TREM2+ macrophage": (0.08, 0.53, "proteolysis"), + "PLAU / PLAT": (0.28, 0.58, "proteolysis"), + "Plasmin": (0.45, 0.58, "proteolysis"), + "MMP2 / 9 / 14": (0.28, 0.34, "proteolysis"), + "ECM cleavage": (0.45, 0.34, "proteolysis"), + "THBS-dependent TGF-beta activation": (0.55, 0.79, "matrix"), + "Active TGF-beta": (0.68, 0.64, "retention"), + "HSC retention": (0.81, 0.64, "retention"), + "SPON1-rich matrix": (0.78, 0.87, "retention"), + "Integrin alpha-v": (0.93, 0.87, "retention"), + "SERPINE1 / PAI-1": (0.59, 0.42, "retention"), + "TIMP1 / TIMP2": (0.73, 0.42, "retention"), + "LOX / crosslinking": (0.84, 0.28, "mechanical"), + "Stiff ECM": (0.93, 0.28, "mechanical"), + "YAP / TEAD": (0.93, 0.09, "mechanical"), + "AP-1 / RUNX": (0.80, 0.09, "mechanical"), + "Retained matrix": (0.57, 0.12, "matrix"), +} + +NODE_WIDTH = { + "THBS-dependent TGF-beta activation": 0.16, + "WNT9B+ endothelium": 0.14, + "TREM2+ macrophage": 0.14, + "SERPINE1 / PAI-1": 0.13, + "LOX / crosslinking": 0.13, + "SPON1-rich matrix": 0.13, +} + +CURVATURE = { + "E03": -0.08, + "E05": 0.10, + "E07": -0.08, + "E08": 0.10, + "E09": 0.08, + "E10": -0.22, + "E11": 0.10, + "E12": -0.08, + "E13": 0.18, + "E14": -0.17, + "E17": 0.07, + "E20": -0.19, + "E21": 0.08, + "E22": 0.16, + "E24": -0.10, +} + + +def draw_node(ax: plt.Axes, name: str, x: float, y: float, category: str) -> None: + width = NODE_WIDTH.get(name, 0.115) + height = 0.072 + style = NODE_STYLE[category] + box = FancyBboxPatch( + (x - width / 2, y - height / 2), + width, + height, + boxstyle="round,pad=0.008,rounding_size=0.007", + facecolor=style["face"], + edgecolor=style["edge"], + linewidth=1.25, + zorder=3, + ) + ax.add_patch(box) + label = name.replace("THBS-dependent TGF-beta activation", "THBS-dependent\nTGF-beta activation") + ax.text( + x, + y, + label, + ha="center", + va="center", + color=style["text"], + fontsize=7.0 if "\n" in label else 7.4, + fontweight="semibold", + zorder=4, + ) + + +def draw_edge(ax: plt.Axes, row: pd.Series) -> None: + source = NODES[row.source] + target = NODES[row.target] + style = EDGE_STYLE[row.evidence_class] + arrowstyle = "-[" if row.relation == "inhibits" else "-|>" + patch = FancyArrowPatch( + (source[0], source[1]), + (target[0], target[1]), + arrowstyle=arrowstyle, + mutation_scale=10.5, + shrinkA=23, + shrinkB=24, + connectionstyle=f"arc3,rad={CURVATURE.get(row.edge_id, 0.0)}", + color=style["color"], + linestyle=style["linestyle"], + linewidth=style["linewidth"], + alpha=0.92, + zorder=1, + ) + ax.add_patch(patch) + + +def build(edges: pd.DataFrame, output: Path) -> None: + unknown_nodes = (set(edges.source) | set(edges.target)) - set(NODES) + if unknown_nodes: + raise ValueError(f"Missing node coordinates: {sorted(unknown_nodes)}") + unknown_classes = set(edges.evidence_class) - set(EDGE_STYLE) + if unknown_classes: + raise ValueError(f"Unknown evidence classes: {sorted(unknown_classes)}") + + mpl.rcParams["svg.fonttype"] = "none" + mpl.rcParams["font.family"] = "Arial" + fig, ax = plt.subplots(figsize=(14.5, 8.3), facecolor="white") + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + ax.axis("off") + + ax.axvspan(0.005, 0.50, ymin=0.055, ymax=0.94, color="#F3F9F9", zorder=0) + ax.axvspan(0.50, 0.995, ymin=0.055, ymax=0.94, color="#FBF6F7", zorder=0) + ax.text(0.025, 0.955, "RESOLVER ACCESS", color="#267B83", fontsize=11, fontweight="bold") + ax.text(0.525, 0.955, "RETENTION REINFORCEMENT", color="#98384D", fontsize=11, fontweight="bold") + + for _, row in edges.iterrows(): + draw_edge(ax, row) + for name, (x, y, category) in NODES.items(): + draw_node(ax, name, x, y, category) + + loop_specs = [ + ("1", 0.64, 0.90, "TGF-beta - SPON1 - alpha-v"), + ("2", 0.79, 0.20, "LOX - stiffness - YAP/AP-1"), + ("3", 0.52, 0.25, "protease restraint - matrix retention"), + ] + for number, x, y, label in loop_specs: + ax.scatter([x], [y], s=165, color="#963A50", edgecolor="white", linewidth=0.8, zorder=5) + ax.text(x, y, number, ha="center", va="center", color="white", fontsize=8, fontweight="bold", zorder=6) + ax.text(x + 0.018, y, label, ha="left", va="center", color="#6E3947", fontsize=7.2, zorder=5) + + handles = [ + plt.Line2D([0], [0], color=EDGE_STYLE[name]["color"], linestyle=EDGE_STYLE[name]["linestyle"], linewidth=2, label=name) + for name in ["literature-established", "project-supported association", "testable candidate edge"] + ] + ax.legend( + handles=handles, + loc="lower center", + bbox_to_anchor=(0.50, 0.002), + frameon=False, + ncol=3, + fontsize=8, + handlelength=3.2, + columnspacing=2.0, + ) + ax.text( + 0.995, + 0.018, + "arrow = activation T-bar = inhibition", + ha="right", + va="bottom", + fontsize=6.8, + color="#70777B", + ) + ax.set_title( + "Evidence-coded candidate circuit for HSC retention and matrix persistence", + loc="left", + fontsize=15, + fontweight="bold", + pad=8, + ) + + output.parent.mkdir(parents=True, exist_ok=True) + fig.savefig(output.with_suffix(".svg"), bbox_inches="tight") + fig.savefig(output.with_suffix(".pdf"), bbox_inches="tight") + fig.savefig(output.with_suffix(".png"), dpi=320, bbox_inches="tight") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--edges", type=Path, default=DEFAULT_EDGES) + parser.add_argument("--output", type=Path, default=DEFAULT_OUTPUT) + return parser.parse_args() + + +def main() -> None: + args = parse_args() + edges = pd.read_csv(args.edges, sep="\t") + build(edges, args.output) + print(f"Wrote {args.output}.svg/.pdf/.png from {len(edges)} evidence-coded edges") + + +if __name__ == "__main__": + main() diff --git a/code/figures/rebuild_main_figure_plates.py b/code/figures/rebuild_main_figure_plates.py new file mode 100644 index 0000000..972e645 --- /dev/null +++ b/code/figures/rebuild_main_figure_plates.py @@ -0,0 +1,260 @@ +#!/usr/bin/env python3 +"""Apply terminology-safe SVG edits and compose the evidence-coded Figure 7 plate.""" + +from __future__ import annotations + +import argparse +import copy +from pathlib import Path +import re +import subprocess +import xml.etree.ElementTree as ET + + +REPO_ROOT = Path(__file__).resolve().parents[2] +DEFAULT_FIGURES = REPO_ROOT / "figures/main" +DEFAULT_PANELS = REPO_ROOT / "figures/source_panels" +SVG_NS = "http://www.w3.org/2000/svg" +XLINK_NS = "http://www.w3.org/1999/xlink" +ET.register_namespace("", SVG_NS) +ET.register_namespace("xlink", XLINK_NS) + + +TEXT_REPLACEMENTS = { + "Figure_1_Clinical_Cohort_and_Persistence.svg": [ + ("one scan per hashed MRN", "one index scan per linked patient"), + ("Other-department", "Department-based"), + ("subcohort", "transport set"), + ( + "Internal, temporal, and independent-subcohort validation", + "Internal, temporal, and department-based transport assessment", + ), + ( + "Internal, temporal, and independent-transport set validation", + "Internal, temporal, and department-based transport assessment", + ), + ], + "Figure_2_Withdrawal_and_Resolver_Timing.svg": [ + ("Lock Proxy", "HSC-retention proxy"), + ("Resolver Proxy", "Resolver proxy"), + ], + "Figure_5_Progressive_Retention_Domain_Occupation.svg": [ + ("Largest locked domain / biopsy area", "Largest retention-dominant domain / biopsy area"), + ("F One locked domain becomes dominant", "F Retention domains coalesce"), + ("F One retention-dominant domain becomes dominant", "F Retention domains coalesce"), + ("Resolved–locked interface fraction", "Resolver–retention interface fraction"), + ("locked domains", "retention domains"), + ("Locked-posterior threshold", "Retention-component posterior threshold"), + ("J Mean basin composition", "J Mean static-component composition"), + ("K Patient-level occupancy distributions", "K Biopsy-level occupancy distributions"), + ("K Biopsy-level occupancy distributions", "K Patient-cluster occupancy distributions"), + ("Biopsy state fraction", "Patient-cluster state fraction"), + ("locked=", "retention-dominant="), + ("Resolved", "Resolver-accessible"), + ("Locked", "Retention-dominant"), + ("Transition", "Intermediate"), + ("locked", "retention-dominant"), + ("resolved", "resolver-accessible"), + ("transition", "intermediate"), + ], +} + +SOURCE_PANEL_REPLACEMENTS = { + "Fig7C_Dual_Axis_Gate.svg": [ + ("Phase-weighted basin-switch score", "Phase-weighted control score"), + ], +} + + +def replace_fragment(node: ET.Element, old: str, new: str) -> None: + if node.text: + node.text = node.text.replace(old, new) + if node.tail: + node.tail = node.tail.replace(old, new) + for child in node: + replace_fragment(child, old, new) + + +def rewrite_svg(path: Path, replacements: list[tuple[str, str]]) -> None: + tree = ET.parse(path) + root = tree.getroot() + for old, new in replacements: + replace_fragment(root, old, new) + tree.write(path, encoding="utf-8", xml_declaration=True) + + +def find_parent(root: ET.Element, child: ET.Element) -> ET.Element | None: + for parent in root.iter(): + if child in list(parent): + return parent + return None + + +def retune_figure_5(path: Path) -> None: + """Remove duplicate legends and space the retained three-state legend.""" + tree = ET.parse(path) + root = tree.getroot() + by_id = {node.get("id"): node for node in root.iter() if node.get("id")} + + for node in root.iter(): + if node.tag.endswith("text") and node.text and "becomes dominant" in node.text: + node.text = "F Retention domains coalesce" + + for legend_id in ("panel2_gGroup_06_2_legend_1", "panel2_gGroup_06_2_legend_2"): + legend = by_id.get(legend_id) + if legend is not None: + parent = find_parent(root, legend) + if parent is not None: + parent.remove(legend) + + placements = { + "panel1_use4442": 487.0, + "panel1_text4443": 501.0, + "panel1_use4443": 584.0, + "panel1_text4444": 598.0, + "panel1_use4444": 684.0, + "panel1_text4445": 698.0, + } + for node_id, x_value in placements.items(): + node = by_id.get(node_id) + if node is None: + continue + node.set("x", f"{x_value:g}") + if node.tag.endswith("text"): + y_value = float(node.get("y", "0")) + node.set("transform", f"rotate(0 {x_value:g} {y_value:g})") + style = node.get("style", "") + node.set("style", re.sub(r"font-size:\s*7\.8px", "font-size:7.2px", style)) + + tree.write(path, encoding="utf-8", xml_declaration=True) + + +def svg_viewbox(root: ET.Element) -> tuple[float, float, float, float]: + raw = root.get("viewBox") + if raw: + values = [float(value) for value in re.split(r"[ ,]+", raw.strip())] + if len(values) == 4: + return tuple(values) # type: ignore[return-value] + width = float(re.sub(r"[^0-9.+-]", "", root.get("width", "1000"))) + height = float(re.sub(r"[^0-9.+-]", "", root.get("height", "1000"))) + return 0.0, 0.0, width, height + + +def prefix_ids(root: ET.Element, prefix: str) -> None: + id_map: dict[str, str] = {} + for node in root.iter(): + old = node.get("id") + if old: + new = f"{prefix}_{old}" + id_map[old] = new + node.set("id", new) + if not id_map: + return + pattern = re.compile(r"#([A-Za-z_][A-Za-z0-9_.:-]*)") + for node in root.iter(): + for attribute, value in list(node.attrib.items()): + if "#" in value: + node.set(attribute, pattern.sub(lambda match: "#" + id_map.get(match.group(1), match.group(1)), value)) + if node.tag.endswith("style") and node.text and "#" in node.text: + node.text = pattern.sub(lambda match: "#" + id_map.get(match.group(1), match.group(1)), node.text) + + +def add_nested_panel( + canvas: ET.Element, + path: Path, + label: str, + cell: tuple[float, float, float, float], + prefix: str, +) -> None: + x, y, width, height = cell + source = ET.parse(path).getroot() + prefix_ids(source, prefix) + viewbox = svg_viewbox(source) + nested = ET.SubElement( + canvas, + f"{{{SVG_NS}}}svg", + { + "x": f"{x:g}", + "y": f"{y:g}", + "width": f"{width:g}", + "height": f"{height:g}", + "viewBox": " ".join(f"{value:g}" for value in viewbox), + "preserveAspectRatio": "xMidYMid meet", + }, + ) + for child in list(source): + nested.append(copy.deepcopy(child)) + label_node = ET.SubElement( + canvas, + f"{{{SVG_NS}}}text", + { + "x": f"{max(8, x - 45):g}", + "y": f"{y + 45:g}", + "style": "font-family:Arial,Helvetica,sans-serif;font-size:42px;font-weight:700;fill:#111111;letter-spacing:0", + }, + ) + label_node.text = label + + +def compose_figure_7(panels: Path, output: Path) -> None: + width, height = 3600, 2100 + root = ET.Element( + f"{{{SVG_NS}}}svg", + { + "width": str(width), + "height": str(height), + "viewBox": f"0 0 {width} {height}", + "version": "1.1", + }, + ) + ET.SubElement( + root, + f"{{{SVG_NS}}}rect", + {"x": "0", "y": "0", "width": str(width), "height": str(height), "fill": "#ffffff"}, + ) + specs = [ + ("Fig7A_Evidence_Coded_Mechanism.svg", "A", (60, 30, 1720, 1050)), + ("Fig7B_Perturbation_Triangulation.svg", "B", (1820, 30, 1720, 1050)), + ("Fig7C_Dual_Axis_Gate.svg", "C", (60, 1120, 1720, 940)), + ("Fig7D_OrderAware_Score_Audit.svg", "D", (1820, 1220, 1720, 640)), + ] + for index, (filename, label, cell) in enumerate(specs, start=1): + add_nested_panel(root, panels / filename, label, cell, f"fig7_{index}") + ET.ElementTree(root).write(output, encoding="utf-8", xml_declaration=True) + + +def render(svg: Path) -> None: + subprocess.run(["rsvg-convert", "-f", "pdf", "-o", str(svg.with_suffix(".pdf")), str(svg)], check=True) + subprocess.run(["rsvg-convert", "-w", "3200", "-o", str(svg.with_suffix(".png")), str(svg)], check=True) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--figures-dir", type=Path, default=DEFAULT_FIGURES) + parser.add_argument("--source-panels", type=Path, default=DEFAULT_PANELS) + return parser.parse_args() + + +def main() -> None: + args = parse_args() + for filename, replacements in SOURCE_PANEL_REPLACEMENTS.items(): + path = args.source_panels / filename + if not path.exists(): + raise FileNotFoundError(path) + rewrite_svg(path, replacements) + for filename, replacements in TEXT_REPLACEMENTS.items(): + path = args.figures_dir / filename + if not path.exists(): + raise FileNotFoundError(path) + rewrite_svg(path, replacements) + if filename == "Figure_5_Progressive_Retention_Domain_Occupation.svg": + retune_figure_5(path) + render(path) + figure_7 = args.figures_dir / "Figure_7_Mechanism_and_OrderAware_Nomination.svg" + compose_figure_7(args.source_panels, figure_7) + render(figure_7) + print("Rebuilt terminology-safe Figures 1, 2, 5 and evidence-coded Figure 7") + + +if __name__ == "__main__": + main() diff --git a/code/governed_clinical_transparency/analyze_masld_flow_panel.py b/code/governed_clinical_transparency/analyze_masld_flow_panel.py new file mode 100644 index 0000000..25c1b61 --- /dev/null +++ b/code/governed_clinical_transparency/analyze_masld_flow_panel.py @@ -0,0 +1,319 @@ +#!/usr/bin/env python3 +"""Deidentify and analyze real-world lymphocyte panels from fatty-liver-coded encounters.""" + +from __future__ import annotations + +import argparse +import hashlib +import json +from pathlib import Path +import re + +import matplotlib.pyplot as plt +import matplotlib.dates as mdates +import numpy as np +import pandas as pd +import seaborn as sns +from sklearn.decomposition import PCA +from sklearn.preprocessing import StandardScaler +import statsmodels.api as sm + + +REPO_ROOT = Path(__file__).resolve().parents[2] +RAW = REPO_ROOT / "data/governed/flow_panel" +RESULTS = REPO_ROOT / "results/flow_panel" +FIGURES = RESULTS / "figures" +CLINICAL = REPO_ROOT / "data/governed/clinical/matched_90d.parquet" +SALT_PATH = REPO_ROOT / "data/governed/clinical_hash_salt.txt" + +MARKERS = ["CD16+CD56+", "CD3+", "CD3+CD4+", "CD3+CD8+", "CD3-CD19+", "CD4/CD8"] +DISPLAY = { + "CD16+CD56+": "NK", + "CD3+": "T", + "CD3+CD4+": "CD4 T", + "CD3+CD8+": "CD8 T", + "CD3-CD19+": "B", + "CD4/CD8": "CD4/CD8", +} +CONTEXT_ORDER = ["metabolic-dominant", "acute-inflammatory", "oncology/hematology"] +CONTEXT_COLORS = { + "metabolic-dominant": "#2A9D8F", + "acute-inflammatory": "#E2A33A", + "oncology/hematology": "#B4495B", +} + + +def digest(salt: str, namespace: str, value: object) -> str: + payload = f"{salt}|{namespace}|{str(value).strip()}".encode() + return hashlib.sha256(payload).hexdigest() + + +def bh(values: pd.Series) -> np.ndarray: + p = values.to_numpy(float) + order = np.argsort(p) + q = p[order] * len(p) / np.arange(1, len(p) + 1) + q = np.minimum.accumulate(q[::-1])[::-1] + result = np.empty_like(q) + result[order] = np.clip(q, 0, 1) + return result + + +def load_panel() -> pd.DataFrame: + salt = SALT_PATH.read_text().strip() + frames = [] + for path in sorted(RAW.glob("*.xlsx")): + local = pd.read_excel(path) + local["source_file"] = path.name + frames.append(local) + long = pd.concat(frames, ignore_index=True) + long["sex"] = long["性别"].map({"男": "M", "女": "F"}) + long["birth_date"] = pd.to_datetime(long["出生日期"], errors="coerce") + long["flow_timestamp"] = pd.to_datetime(long["审核时间"], errors="coerce") + key_plain = long.birth_date.dt.strftime("%Y-%m-%d") + "|" + long.sex + long["dob_sex_key_hash"] = key_plain.map(lambda value: digest(salt, "dob_sex", value)) + long["flow_subject_hash"] = long["身份证号"].astype(str).map(lambda value: digest(salt, "flow_subject", value)) + long["flow_event_hash"] = [ + digest(salt, "flow_event", f"{subject}|{timestamp}|{barcode}") + for subject, timestamp, barcode in zip(long.flow_subject_hash, long.flow_timestamp, long["条码号"]) + ] + index = [ + "flow_event_hash", "flow_subject_hash", "dob_sex_key_hash", "flow_timestamp", + "birth_date", "sex", "年龄", "诊断", "source_file", + ] + wide = long.pivot_table(index=index, columns="项目代码", values="测定结果", aggfunc="first").reset_index() + wide.columns.name = None + missing = [marker for marker in MARKERS if marker not in wide] + if missing: + raise ValueError(f"Missing flow markers: {missing}") + wide["age"] = pd.to_numeric(wide["年龄"].astype(str).str.extract(r"(\d+)")[0], errors="coerce") + diagnosis = wide["诊断"].fillna("") + oncology = diagnosis.str.contains(r"淋巴瘤|白血病|骨髓瘤|骨髓增生|恶性肿瘤|化学治疗|靶向治疗", regex=True) + infection = diagnosis.str.contains(r"感染|肺炎|发热|败血|脓毒|急性下呼吸道感染", regex=True) + wide["context"] = np.where( + oncology, + "oncology/hematology", + np.where(infection, "acute-inflammatory", "metabolic-dominant"), + ) + wide["diabetes"] = diagnosis.str.contains("糖尿病") + wide["hypertension"] = diagnosis.str.contains("高血压") + wide["viral_hepatitis"] = diagnosis.str.contains(r"乙型病毒性肝炎|丙型病毒性肝炎|病毒性肝炎", regex=True) + wide["liver_dysfunction"] = diagnosis.str.contains(r"肝功能不全|肝硬化|肝衰竭", regex=True) + total = wide["CD16+CD56+"] + wide["CD3+"] + wide["CD3-CD19+"] + wide["NK_fraction"] = wide["CD16+CD56+"] / total + wide["T_fraction"] = wide["CD3+"] / total + wide["B_fraction"] = wide["CD3-CD19+"] / total + wide["CD4_T_fraction"] = wide["CD3+CD4+"] / wide["CD3+"] + wide["CD8_T_fraction"] = wide["CD3+CD8+"] / wide["CD3+"] + wide["computed_CD4_CD8"] = wide["CD3+CD4+"] / wide["CD3+CD8+"] + wide["ratio_relative_error"] = (wide["computed_CD4_CD8"] - wide["CD4/CD8"]).abs() / wide["CD4/CD8"].replace(0, np.nan) + return wide + + +def match_clinical(panel: pd.DataFrame) -> pd.DataFrame: + clinical = pd.read_parquet(CLINICAL) + rows = [] + for record in panel.itertuples(index=False): + candidates = clinical.loc[clinical.dob_sex_key_hash.eq(record.dob_sex_key_hash)].copy() + if candidates.empty: + continue + candidates["flow_scan_days"] = ( + candidates.scan_timestamp - record.flow_timestamp + ).abs().dt.total_seconds() / 86400 + best = candidates.sort_values(["flow_scan_days", "scan_timestamp"]).iloc[0] + if best.flow_scan_days <= 90: + rows.append( + { + "flow_event_hash": record.flow_event_hash, + "flow_subject_hash": record.flow_subject_hash, + "scan_hash": best.scan_hash, + "flow_scan_days": float(best.flow_scan_days), + "LSM": best.LSM, + "CAP": best.CAP, + "fibrosis_stage": best.fibrosis_stage, + "qc_pass": best.qc_pass, + "BMI": best.BMI, + } + ) + return pd.DataFrame(rows) + + +def context_models(panel: pd.DataFrame) -> pd.DataFrame: + rows = [] + context = pd.Categorical(panel.context, CONTEXT_ORDER) + dummies = pd.get_dummies(context, drop_first=True, dtype=float) + sex = panel.sex.eq("M").astype(float).to_numpy() + age = (panel.age - panel.age.mean()) / panel.age.std(ddof=1) + x = np.column_stack([np.ones(len(panel)), dummies.to_numpy(float), age.to_numpy(float), sex]) + terms = ["intercept", "acute-inflammatory", "oncology/hematology", "age_z", "male"] + groups = pd.Categorical(panel.flow_subject_hash).codes + for marker in MARKERS: + y = np.log1p(panel[marker].to_numpy(float)) + y = (y - y.mean()) / y.std(ddof=1) + fit = sm.OLS(y, x).fit(cov_type="cluster", cov_kwds={"groups": groups}) + for index, term in enumerate(terms[1:3], start=1): + rows.append( + { + "marker": marker, + "comparison": f"{term} vs metabolic-dominant", + "beta_sd": float(fit.params[index]), + "se": float(fit.bse[index]), + "ci_low": float(fit.params[index] - 1.96 * fit.bse[index]), + "ci_high": float(fit.params[index] + 1.96 * fit.bse[index]), + "p_value": float(fit.pvalues[index]), + } + ) + result = pd.DataFrame(rows) + result["fdr"] = bh(result.p_value) + return result + + +def immune_pca(panel: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + features = MARKERS + matrix = np.log1p(panel[features].to_numpy(float)) + matrix = StandardScaler().fit_transform(matrix) + model = PCA(n_components=2, random_state=20260712) + coordinates = model.fit_transform(matrix) + scores = panel[["flow_event_hash", "flow_subject_hash", "flow_timestamp", "context", "age", "sex"]].copy() + scores["PC1"] = coordinates[:, 0] + scores["PC2"] = coordinates[:, 1] + loadings = pd.DataFrame( + { + "marker": features, + "PC1_loading": model.components_[0], + "PC2_loading": model.components_[1], + "PC1_variance": model.explained_variance_ratio_[0], + "PC2_variance": model.explained_variance_ratio_[1], + } + ) + return scores, loadings + + +def plot_figure(panel: pd.DataFrame, models: pd.DataFrame, pca_scores: pd.DataFrame) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(15.5, 11.5)) + grid = fig.add_gridspec(2, 3, left=.06, right=.98, bottom=.07, top=.91, wspace=.35, hspace=.36) + + ax = fig.add_subplot(grid[0, 0]) + order = panel.groupby("flow_subject_hash").flow_timestamp.min().sort_values().index + rank = {subject: i for i, subject in enumerate(order)} + for subject, local in panel.groupby("flow_subject_hash", observed=True): + local = local.sort_values("flow_timestamp") + y = rank[subject] + ax.plot(local.flow_timestamp, np.repeat(y, len(local)), color="#C8CED2", lw=.7) + ax.scatter(local.flow_timestamp, np.repeat(y, len(local)), c=local.context.map(CONTEXT_COLORS), s=17, edgecolor="white", linewidth=.3) + ax.set(xlabel="Flow-cytometry date", ylabel="Deidentified patient", yticks=[]) + locator = mdates.AutoDateLocator(minticks=4, maxticks=7) + ax.xaxis.set_major_locator(locator) + ax.xaxis.set_major_formatter(mdates.ConciseDateFormatter(locator)) + ax.set_title("A Real-world sampling architecture", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[0, 1]) + x = panel.T_fraction + .5 * panel.B_fraction + y = np.sqrt(3) / 2 * panel.B_fraction + triangle = np.array([[0,0],[1,0],[.5,np.sqrt(3)/2],[0,0]]) + ax.plot(triangle[:,0],triangle[:,1],color="#4D5559",lw=1) + ax.scatter(x,y,c=panel.context.map(CONTEXT_COLORS),s=32,alpha=.8,edgecolor="white",linewidth=.4) + ax.text(-.03,-.04,"NK",ha="right"); ax.text(1.03,-.04,"T",ha="left"); ax.text(.5,.91,"B",ha="center") + ax.set_aspect("equal"); ax.set_axis_off() + ax.set_title("B Lymphocyte composition simplex", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[0, 2]) + for context in CONTEXT_ORDER: + local = pca_scores.loc[pca_scores.context.eq(context)] + ax.scatter(local.PC1,local.PC2,s=34,color=CONTEXT_COLORS[context],label=context,alpha=.82,edgecolor="white",linewidth=.4) + ax.axhline(0,color="#D5D9DB",lw=.7); ax.axvline(0,color="#D5D9DB",lw=.7) + ax.set(xlabel="Immune PC1",ylabel="Immune PC2") + ax.set_title("C Peripheral immune-state diversity", loc="left", fontweight="bold") + ax.legend(frameon=False,fontsize=7,loc="best") + + ax = fig.add_subplot(grid[1, 0]) + plot = models.loc[models.comparison.str.startswith("acute")].copy() + plot["label"] = plot.marker.map(DISPLAY) + plot = plot.sort_values("beta_sd") + y = np.arange(len(plot)) + ax.errorbar(plot.beta_sd,y,xerr=[plot.beta_sd-plot.ci_low,plot.ci_high-plot.beta_sd],fmt="o",color=CONTEXT_COLORS["acute-inflammatory"],ecolor=CONTEXT_COLORS["acute-inflammatory"],capsize=3) + ax.axvline(0,color="#666",lw=.8) + ax.set_yticks(y,plot.label); ax.set_xlabel("Adjusted difference (SD)") + ax.set_title("D Acute-inflammatory immune displacement", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 1]) + correlation = panel[MARKERS].rename(columns=DISPLAY).corr(method="spearman") + correlation.index.name = None + correlation.columns.name = None + sns.heatmap(correlation,cmap="RdBu_r",center=0,vmin=-1,vmax=1,square=True,annot=True,fmt=".2f",annot_kws={"fontsize":7},cbar_kws={"shrink":.65},ax=ax) + ax.set_title("E Coordinated lymphocyte architecture", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 2]) + repeated = panel.groupby("flow_subject_hash").filter(lambda x: len(x)>1).copy() + repeated["days"] = repeated.groupby("flow_subject_hash").flow_timestamp.transform(lambda x:(x-x.min()).dt.total_seconds()/86400) + for subject, local in repeated.groupby("flow_subject_hash",observed=True): + local=local.sort_values("days") + ax.plot(local.days,local["CD4/CD8"],color="#87949A",lw=1,alpha=.75) + ax.scatter(local.days,local["CD4/CD8"],c=local.context.map(CONTEXT_COLORS),s=24,edgecolor="white",linewidth=.3) + ax.axhline(1,color="#C43D55",ls="--",lw=1) + ax.set(xlabel="Days from first panel",ylabel="CD4/CD8 ratio") + ax.set_title("F Within-patient immune-state mobility", loc="left", fontweight="bold") + + for ax in fig.axes: + if ax.axison: + ax.spines[["top","right"]].set_visible(False) + fig.suptitle("Peripheral lymphocyte-state diversity in fatty-liver-coded clinical encounters",fontsize=16,fontweight="bold") + fig.savefig(FIGURES / "MASLD_peripheral_lymphocyte_landscape.png",dpi=320,facecolor="white") + fig.savefig(FIGURES / "MASLD_peripheral_lymphocyte_landscape.pdf",facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser=argparse.ArgumentParser(description=__doc__) + parser.add_argument("--flow-input-dir",type=Path,default=RAW) + parser.add_argument("--clinical-linkage",type=Path,default=CLINICAL) + parser.add_argument("--hash-salt",type=Path,default=SALT_PATH) + parser.add_argument("--output-dir",type=Path,default=RESULTS) + return parser.parse_args() + + +def main() -> None: + global RAW,CLINICAL,SALT_PATH,RESULTS,FIGURES + args=parse_args() + RAW,CLINICAL,SALT_PATH,RESULTS=args.flow_input_dir,args.clinical_linkage,args.hash_salt,args.output_dir + FIGURES=RESULTS/"figures" + RESULTS.mkdir(parents=True,exist_ok=True) + FIGURES.mkdir(parents=True,exist_ok=True) + FIGURES.mkdir(parents=True,exist_ok=True) + panel=load_panel() + clinical=match_clinical(panel) + models=context_models(panel) + pca_scores,pca_loadings=immune_pca(panel) + plot_figure(panel,models,pca_scores) + + safe_columns=[ + "flow_event_hash","flow_subject_hash","dob_sex_key_hash","flow_timestamp","sex","age","context", + "diabetes","hypertension","viral_hepatitis","liver_dysfunction",*MARKERS, + "NK_fraction","T_fraction","B_fraction","CD4_T_fraction","CD8_T_fraction","ratio_relative_error", + ] + panel[safe_columns].to_parquet(RESULTS/"flow_panel_deidentified.parquet",index=False) + panel[safe_columns].to_csv(RESULTS/"flow_panel_deidentified.tsv",sep="\t",index=False) + models.to_csv(RESULTS/"flow_context_models.tsv",sep="\t",index=False) + pca_scores.to_csv(RESULTS/"flow_immune_pca_scores.tsv",sep="\t",index=False) + pca_loadings.to_csv(RESULTS/"flow_immune_pca_loadings.tsv",sep="\t",index=False) + clinical.to_csv(RESULTS/"flow_liver_stiffness_90d_linkage.tsv",sep="\t",index=False) + + context_counts=panel.groupby("context",observed=True).agg(panels=("flow_event_hash","size"),patients=("flow_subject_hash","nunique")).reset_index() + context_counts.to_csv(RESULTS/"flow_context_counts.tsv",sep="\t",index=False) + summary={ + "n_rows_original":int(len(panel)*len(MARKERS)), + "n_complete_panels":int(len(panel)), + "n_patients":int(panel.flow_subject_hash.nunique()), + "n_repeated_patients":int((panel.groupby("flow_subject_hash").size()>1).sum()), + "max_panels_per_patient":int(panel.groupby("flow_subject_hash").size().max()), + "context_counts":context_counts.to_dict(orient="records"), + "median_ratio_relative_error":float(panel.ratio_relative_error.median()), + "n_liver_stiffness_links_90d":int(len(clinical)), + "role_in_manuscript":"Independent real-world peripheral immune-state atlas and longitudinal supplement; not a fibrosis-stage association cohort.", + } + (RESULTS/"flow_analysis_summary.json").write_text(json.dumps(summary,ensure_ascii=False,indent=2)+"\n") + print(json.dumps(summary,ensure_ascii=False,indent=2)) + + +if __name__=="__main__": + main() diff --git a/code/governed_clinical_transparency/rebuild_final_clinical_visuals.py b/code/governed_clinical_transparency/rebuild_final_clinical_visuals.py new file mode 100644 index 0000000..755c142 --- /dev/null +++ b/code/governed_clinical_transparency/rebuild_final_clinical_visuals.py @@ -0,0 +1,966 @@ +#!/usr/bin/env python3 +"""Rebuild the proprietary clinical evidence layer and publication figures.""" + +from __future__ import annotations + +import argparse +import json +import math +from pathlib import Path + +import matplotlib as mpl +import matplotlib.pyplot as plt +from matplotlib.gridspec import GridSpec +from matplotlib.patches import FancyBboxPatch, PathPatch, Rectangle +from matplotlib.path import Path as MplPath +from mpl_toolkits.axes_grid1.inset_locator import inset_axes +import numpy as np +import pandas as pd +import seaborn as sns +from scipy.stats import norm +import statsmodels.api as sm +import statsmodels.formula.api as smf +from sklearn.linear_model import LogisticRegression +from sklearn.metrics import brier_score_loss, roc_auc_score +from sklearn.model_selection import StratifiedKFold, cross_val_predict +from sklearn.pipeline import make_pipeline +from sklearn.preprocessing import StandardScaler + + +SCRIPT = Path(__file__).resolve() +REPO_ROOT = SCRIPT.parents[2] +CLIN = REPO_ROOT / "data/governed/clinical" +DYN = REPO_ROOT / "data/governed/dynamics" +OUTPUT_ROOT = REPO_ROOT / "results/clinical" +TABLES = OUTPUT_ROOT / "source_tables" +MAIN = OUTPUT_ROOT / "main_figures" +ED = OUTPUT_ROOT / "extended_data_figures" +LOGS = OUTPUT_ROOT / "logs" + + +COLORS = { + "blue": "#2678B2", + "cyan": "#47B5C4", + "teal": "#2A9D8F", + "gold": "#E9C46A", + "orange": "#F4A261", + "red": "#D1495B", + "magenta": "#B05A8F", + "purple": "#6C5B7B", + "gray": "#8A8F98", + "lightgray": "#E8EAED", + "dark": "#20242A", +} +STATE_COLORS = { + "LL": "#4C9F70", + "HL": "#E9C46A", + "LH": "#8F6BAE", + "HH": "#D1495B", +} +STATE_LABELS = { + "LL": "Low CAP / low LSM", + "HL": "High CAP / low LSM", + "LH": "Low CAP / high LSM", + "HH": "High CAP / high LSM", +} + + +mpl.rcParams.update( + { + "font.family": "sans-serif", + "font.sans-serif": ["Arial", "Helvetica", "DejaVu Sans"], + "font.size": 8, + "axes.titlesize": 9, + "axes.labelsize": 8, + "xtick.labelsize": 7, + "ytick.labelsize": 7, + "legend.fontsize": 7, + "axes.linewidth": 0.8, + "figure.dpi": 160, + "savefig.dpi": 360, + "savefig.bbox": "tight", + "svg.fonttype": "none", + "pdf.fonttype": 42, + "ps.fonttype": 42, + "axes.spines.top": False, + "axes.spines.right": False, + "axes.grid": False, + "text.color": COLORS["dark"], + "axes.labelcolor": COLORS["dark"], + "xtick.color": COLORS["dark"], + "ytick.color": COLORS["dark"], + } +) +sns.set_style("white") + + +def panel(ax: plt.Axes, letter: str, title: str) -> None: + ax.text(-0.08, 1.06, letter, transform=ax.transAxes, fontsize=13, fontweight="bold", va="top") + ax.set_title(title, loc="left", fontsize=9.5, fontweight="bold", pad=7) + + +def save_figure(fig: plt.Figure, stem: Path) -> None: + for ext in ["png", "pdf", "svg"]: + fig.savefig(stem.with_suffix(f".{ext}"), facecolor="white") + plt.close(fig) + + +def median_iqr(s: pd.Series, digits: int = 1) -> str: + x = pd.to_numeric(s, errors="coerce").dropna() + q1, med, q3 = x.quantile([0.25, 0.5, 0.75]) + return f"{med:.{digits}f} [{q1:.{digits}f}, {q3:.{digits}f}]" + + +def n_pct(mask: pd.Series) -> str: + x = mask.dropna().astype(bool) + return f"{int(x.sum()):,} ({100 * x.mean():.1f}%)" + + +def smd_cont(a: pd.Series, b: pd.Series) -> float: + a = pd.to_numeric(a, errors="coerce").dropna() + b = pd.to_numeric(b, errors="coerce").dropna() + pooled = math.sqrt((a.var(ddof=1) + b.var(ddof=1)) / 2) + return float((b.mean() - a.mean()) / pooled) if pooled > 0 else np.nan + + +def smd_binary(a: pd.Series, b: pd.Series) -> float: + pa, pb = a.astype(float).mean(), b.astype(float).mean() + pooled = math.sqrt((pa * (1 - pa) + pb * (1 - pb)) / 2) + return float((pb - pa) / pooled) if pooled > 0 else np.nan + + +def bootstrap_auc(y: np.ndarray, p: np.ndarray, n_boot: int = 1200, seed: int = 20260712) -> tuple[float, float, float]: + y = np.asarray(y, dtype=int) + p = np.asarray(p, dtype=float) + estimate = roc_auc_score(y, p) + rng = np.random.default_rng(seed) + vals: list[float] = [] + n = len(y) + for _ in range(n_boot): + ind = rng.integers(0, n, n) + if np.unique(y[ind]).size == 2: + vals.append(roc_auc_score(y[ind], p[ind])) + lo, hi = np.quantile(vals, [0.025, 0.975]) + return float(estimate), float(lo), float(hi) + + +def odds_ratio_glm(data: pd.DataFrame, outcome: str, predictor: str) -> tuple[float, float, float, float]: + d = data[[outcome, predictor]].dropna().copy() + d[outcome] = d[outcome].astype(int) + d[predictor] = (d[predictor] - d[predictor].mean()) / d[predictor].std(ddof=1) + model = sm.GLM(d[outcome], sm.add_constant(d[predictor]), family=sm.families.Binomial()).fit() + beta = model.params[predictor] + lo, hi = model.conf_int().loc[predictor] + return float(np.exp(beta)), float(np.exp(lo)), float(np.exp(hi)), float(model.pvalues[predictor]) + + +def state_code(cap: pd.Series, lsm: pd.Series) -> pd.Series: + return pd.Series( + np.select( + [ + (cap < 280) & (lsm < 9.5), + (cap >= 280) & (lsm < 9.5), + (cap < 280) & (lsm >= 9.5), + (cap >= 280) & (lsm >= 9.5), + ], + ["LL", "HL", "LH", "HH"], + default="NA", + ), + index=cap.index, + ) + + +def build_longitudinal(elasto: pd.DataFrame) -> pd.DataFrame: + rows: list[dict[str, object]] = [] + for pid, group in elasto.groupby("medical_record_hash", sort=False): + group = group.drop_duplicates("scan_date").sort_values("scan_timestamp") + if len(group) < 2: + continue + first, last = group.iloc[0], group.iloc[-1] + days = int((last.scan_date - first.scan_date).days) + if days < 90: + continue + rows.append( + { + "patient": pid, + "n_scans": len(group), + "baseline_date": first.scan_date, + "followup_days": days, + "age": first.age_at_scan, + "male": int(first.sex == "M"), + "BMI": first.BMI, + "CAP0": first.CAP, + "CAP1": last.CAP, + "LSM0": first.LSM, + "LSM1": last.LSM, + } + ) + d = pd.DataFrame(rows) + d["state0"] = state_code(d.CAP0, d.LSM0) + d["state1"] = state_code(d.CAP1, d.LSM1) + d["delta_CAP"] = d.CAP1 - d.CAP0 + d["relative_LSM"] = d.LSM1 / d.LSM0 - 1 + d["advanced0"] = d.LSM0 >= 9.5 + d["advanced1"] = d.LSM1 >= 9.5 + d["outcome"] = np.select( + [ + d.advanced0 & ~d.advanced1, + ~d.advanced0 & d.advanced1, + d.advanced0 & d.advanced1, + ~d.advanced0 & ~d.advanced1, + ], + ["Threshold regression", "Threshold progression", "Persistent advanced", "Persistent nonadvanced"], + default="Unknown", + ) + d["lsm_change"] = np.select( + [d.relative_LSM <= -0.20, d.relative_LSM >= 0.20], + ["Decrease >=20%", "Increase >=20%"], + default="Stable within 20%", + ) + d["regression_resistant"] = d.advanced0 & d.advanced1 & (d.relative_LSM > -0.20) + d["baseline_era"] = np.where(d.baseline_date.dt.year <= 2024, "2023-2024", "2025-2026") + return d + + +def baseline_table(index: pd.DataFrame) -> pd.DataFrame: + low = index.loc[~index.advanced_fibrosis_lsm_ge9_5] + high = index.loc[index.advanced_fibrosis_lsm_ge9_5] + specs = [ + ("Age, years", "continuous", "age_at_scan", 1), + ("Male sex", "binary", "male", 1), + ("BMI, kg/m2", "continuous", "BMI", 1), + ("CAP, dB/m", "continuous", "CAP", 1), + ("LSM, kPa", "continuous", "LSM", 1), + ("CAP >=248 dB/m", "binary", "cap248", 1), + ("CAP >=280 dB/m", "binary", "cap280", 1), + ("LSM 9.5-<12.5 kPa", "binary", "f3", 1), + ("LSM >=12.5 kPa", "binary", "f4", 1), + ("Gastro/hepatobiliary", "binary", "gi", 1), + ] + rows = [] + for label, kind, col, digits in specs: + if kind == "continuous": + rows.append( + { + "Variable": label, + "All (n=8,142)": median_iqr(index[col], digits), + "LSM <9.5 (n=5,857)": median_iqr(low[col], digits), + "LSM >=9.5 (n=2,285)": median_iqr(high[col], digits), + "SMD": smd_cont(low[col], high[col]), + } + ) + else: + rows.append( + { + "Variable": label, + "All (n=8,142)": n_pct(index[col]), + "LSM <9.5 (n=5,857)": n_pct(low[col]), + "LSM >=9.5 (n=2,285)": n_pct(high[col]), + "SMD": smd_binary(low[col], high[col]), + } + ) + return pd.DataFrame(rows) + + +def validation_analysis(index: pd.DataFrame) -> pd.DataFrame: + features = ["age_at_scan", "male", "BMI", "CAP"] + train = index.loc[index.scan_date.dt.year <= 2024].copy() + temporal = index.loc[index.scan_date.dt.year >= 2025].copy() + model = make_pipeline(StandardScaler(), LogisticRegression(max_iter=2000, random_state=20260712)) + cv = StratifiedKFold(5, shuffle=True, random_state=20260712) + cv_pred = cross_val_predict(model, train[features], train.advanced.astype(int), cv=cv, method="predict_proba")[:, 1] + model.fit(train[features], train.advanced.astype(int)) + temporal_pred = model.predict_proba(temporal[features])[:, 1] + + gi = index.loc[index.gi].copy() + other = index.loc[~index.gi].copy() + dept_model = make_pipeline(StandardScaler(), LogisticRegression(max_iter=2000, random_state=20260712)) + dept_model.fit(gi[features], gi.advanced.astype(int)) + other_pred = dept_model.predict_proba(other[features])[:, 1] + + rows = [] + for label, data, pred in [ + ("Internal 5-fold CV (2023-2024)", train, cv_pred), + ("Temporal holdout (2025-2026)", temporal, temporal_pred), + ("Independent department subcohort", other, other_pred), + ]: + est, lo, hi = bootstrap_auc(data.advanced.to_numpy(), pred) + rows.append( + { + "validation": label, + "n": len(data), + "advanced_n": int(data.advanced.sum()), + "advanced_fraction": float(data.advanced.mean()), + "AUROC": est, + "ci_low": lo, + "ci_high": hi, + "Brier": brier_score_loss(data.advanced.astype(int), pred), + } + ) + return pd.DataFrame(rows) + + +def draw_workflow(ax: plt.Axes) -> None: + ax.set_axis_off() + panel(ax, "A", "Proprietary clinical cohort, fixed eligibility, and de-identification workflow") + items = [ + ("Raw elastography", "9,703 scans\n2023-03-01 to 2026-07-09", COLORS["blue"]), + ("Technical QC", "9,644 scans\n>=10 valid; LSM IQR/M <=0.30", COLORS["cyan"]), + ("Adult analysis", "9,562 scans\nage >=18 years", COLORS["teal"]), + ("Index cohort", "8,142 patients\none scan per hashed MRN", COLORS["gold"]), + ("Clinical linkage", "Metabolic 1,490 | LIS 746\nthree-source 243 scans", COLORS["red"]), + ] + x0, gap, width, height, y = 0.015, 0.018, 0.175, 0.60, 0.18 + for i, (head, body, color) in enumerate(items): + x = x0 + i * (width + gap) + box = FancyBboxPatch( + (x, y), width, height, + boxstyle="round,pad=0.008,rounding_size=0.008", + facecolor="white", edgecolor=color, linewidth=1.6, + transform=ax.transAxes, + ) + ax.add_patch(box) + ax.add_patch(Rectangle((x, y + height - 0.11), width, 0.11, transform=ax.transAxes, facecolor=color, edgecolor="none", alpha=0.95)) + ax.text(x + 0.012, y + height - 0.055, head, transform=ax.transAxes, color="white", fontweight="bold", va="center", fontsize=8.2) + ax.text(x + width / 2, y + 0.24, body, transform=ax.transAxes, ha="center", va="center", fontsize=7.2, linespacing=1.25) + if i < len(items) - 1: + ax.annotate("", xy=(x + width + gap - 0.004, y + height / 2), xytext=(x + width + 0.004, y + height / 2), xycoords=ax.transAxes, arrowprops=dict(arrowstyle="-|>", color=COLORS["gray"], lw=1.2)) + ax.text(0.015, 0.02, "Single center: Fudan University Affiliated Pudong Hospital", transform=ax.transAxes, fontsize=7.4, fontweight="bold") + ax.text(0.42, 0.02, "Linkage: laboratory-verified unique patient key; nearest result within +/-90 days", transform=ax.transAxes, fontsize=7.2) + ax.text(0.985, 0.02, "Ethics details: AUTHORS TO COMPLETE BEFORE SUBMISSION", transform=ax.transAxes, ha="right", fontsize=7.2, color=COLORS["red"], fontweight="bold") + + +def figure_main_1(index: pd.DataFrame, baseline: pd.DataFrame, etiology: pd.DataFrame, validation: pd.DataFrame) -> None: + fig = plt.figure(figsize=(16.2, 10.4)) + gs = GridSpec(3, 12, figure=fig, height_ratios=[1.25, 3.1, 2.8], hspace=0.55, wspace=1.00) + draw_workflow(fig.add_subplot(gs[0, :])) + + ax = fig.add_subplot(gs[1:, :4]) + panel(ax, "B", "Baseline profile of 8,142 adults") + ax.axis("off") + show = baseline.copy().rename( + columns={ + "All (n=8,142)": "All\n(n=8,142)", + "LSM <9.5 (n=5,857)": "LSM <9.5\n(n=5,857)", + "LSM >=9.5 (n=2,285)": "LSM >=9.5\n(n=2,285)", + } + ) + show["SMD"] = show.SMD.map(lambda x: f"{x:.2f}") + table = ax.table(cellText=show.values, colLabels=show.columns, cellLoc="left", colLoc="left", bbox=[0, 0.01, 1, 0.96], colWidths=[0.34, 0.22, 0.23, 0.23, 0.08]) + table.auto_set_font_size(False) + table.set_fontsize(6.1) + for (row, col), cell in table.get_celld().items(): + cell.set_edgecolor("white") + if row == 0: + cell.set_facecolor(COLORS["dark"]) + cell.get_text().set_color("white") + cell.get_text().set_fontweight("bold") + elif row % 2 == 0: + cell.set_facecolor("#F4F5F6") + if col == 0 and row > 0: + cell.get_text().set_fontweight("bold") + ax.text(0, -0.03, "Values are median [IQR] or n (%). SMD compares LSM strata.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + ax = fig.add_subplot(gs[1, 4:8]) + panel(ax, "C", "LSM-defined imaging strata across calendar years") + stage_order = ["<8.0", "8.0-<9.5", "9.5-<12.5", ">=12.5"] + stage_colors = [COLORS["teal"], COLORS["gold"], COLORS["orange"], COLORS["red"]] + imaging_stratum = pd.cut(index.LSM, [-np.inf, 8.0, 9.5, 12.5, np.inf], right=False, labels=stage_order) + tab = pd.crosstab(index.scan_date.dt.year, imaging_stratum).reindex(columns=stage_order, fill_value=0) + pct = tab.div(tab.sum(axis=1), axis=0) * 100 + bottom = np.zeros(len(pct)) + for stage, color in zip(stage_order, stage_colors): + ax.bar(pct.index.astype(str), pct[stage], bottom=bottom, color=color, width=0.68, label=stage, edgecolor="white", linewidth=0.5) + bottom += pct[stage].to_numpy() + for i, year in enumerate(pct.index): + ax.text(i, 102, f"n={tab.loc[year].sum():,}", ha="center", va="bottom", fontsize=6.5) + ax.set_ylim(0, 109) + ax.set_ylabel("Patients (%)") + ax.set_xlabel("Index year") + ax.legend(frameon=False, ncol=4, loc="lower center", bbox_to_anchor=(0.5, -0.28), title="LSM (kPa)") + + ax = fig.add_subplot(gs[1, 8:12]) + panel(ax, "D", "CAP-LSM landscape separates steatotic and stiffness axes") + hb = ax.hexbin(index.CAP, index.LSM, gridsize=48, mincnt=1, bins="log", cmap="viridis", linewidths=0, extent=[150, 400, 2.5, 33]) + ax.axvline(280, color=COLORS["red"], ls="--", lw=1.1) + ax.axhline(9.5, color=COLORS["red"], ls="--", lw=1.1) + counts = index.state.value_counts() + positions = {"LL": (175, 4.5), "HL": (316, 4.5), "LH": (175, 27.5), "HH": (316, 27.5)} + for st, (x, y) in positions.items(): + ax.text(x, y, f"{st}\nn={counts.get(st, 0):,}", ha="center", va="center", fontsize=7.2, fontweight="bold", bbox=dict(boxstyle="round,pad=0.25", fc="white", ec=STATE_COLORS[st], lw=1.1, alpha=0.9)) + ax.set_xlim(150, 400) + ax.set_ylim(2.5, 33) + ax.set_xlabel("CAP (dB/m)") + ax.set_ylabel("LSM (kPa)") + cb = fig.colorbar(hb, ax=ax, fraction=0.047, pad=0.02) + cb.set_label("log10 density", fontsize=7) + ax.text(0.02, 0.02, "Spearman rho=0.385", transform=ax.transAxes, fontsize=6.8, bbox=dict(fc="white", ec="none", alpha=0.8)) + top = inset_axes(ax, width="82%", height="15%", loc="upper left", borderpad=0.6) + top.hist(index.CAP, bins=44, color=COLORS["blue"], alpha=0.55) + top.patch.set_alpha(0.82) + top.axis("off") + right = inset_axes(ax, width="15%", height="72%", loc="upper right", borderpad=0.6) + right.hist(index.LSM, bins=38, orientation="horizontal", color=COLORS["purple"], alpha=0.55) + right.patch.set_alpha(0.82) + right.axis("off") + + ax = fig.add_subplot(gs[2, 4:8]) + panel(ax, "E", "Observed etiology markers and partial phenotypes") + order = [ + "metabolic_risk_observed", + "metabolic_steatotic_phenotype", + "diagnosis_steatotic_liver_text", + "HBsAg_marker_positive", + "AMA_M2_marker_positive", + "anti_HCV_marker_positive", + ] + labels = { + "metabolic_risk_observed": "Metabolic risk", + "metabolic_steatotic_phenotype": "CAP >=248 + metabolic", + "diagnosis_steatotic_liver_text": "Steatotic-liver text", + "HBsAg_marker_positive": "HBsAg positive", + "AMA_M2_marker_positive": "AMA-M2 positive", + "anti_HCV_marker_positive": "anti-HCV positive", + } + d = etiology.set_index("marker_or_phenotype").loc[order].reset_index() + y = np.arange(len(d))[::-1] + ax.barh(y, 100 * d.proportion, color=[COLORS["gold"], COLORS["orange"], COLORS["gray"], COLORS["blue"], COLORS["magenta"], COLORS["purple"]], height=0.65) + ax.set_yticks(y, [labels[x] for x in d.marker_or_phenotype]) + ax.tick_params(axis="y", labelsize=6.4, pad=2) + ax.set_xlabel("Positive among observed (%)") + ax.set_xlim(0, 100) + for yi, row in zip(y, d.itertuples()): + ax.text(min(98, 100 * row.proportion + 2), yi, f"{row.n_positive}/{row.n_observed}", va="center", fontsize=6.8) + ax.text(0.0, -0.25, "Markers and text-derived phenotypes are not adjudicated etiologies.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + ax = fig.add_subplot(gs[2, 8:12]) + panel(ax, "F", "Internal, temporal, and independent-subcohort validation") + y = np.arange(len(validation))[::-1] + short_validation = { + "Internal 5-fold CV (2023-2024)": "Internal 5-fold CV\n2023-2024", + "Temporal holdout (2025-2026)": "Temporal holdout\n2025-2026", + "Independent department subcohort": "Other-department\nsubcohort", + } + for yi, row in zip(y, validation.itertuples()): + ax.errorbar(row.AUROC, yi, xerr=[[row.AUROC - row.ci_low], [row.ci_high - row.AUROC]], fmt="o", color=COLORS["blue"], capsize=3, lw=1.3, ms=6) + ax.text(row.ci_high + 0.012, yi, f"{row.AUROC:.3f} ({row.ci_low:.3f}-{row.ci_high:.3f})", va="center", fontsize=6.8) + ax.axvline(0.5, color=COLORS["gray"], ls="--", lw=1) + ax.set_yticks(y, [f"{short_validation[r.validation]}\nn={r.n:,}" for r in validation.itertuples()]) + ax.tick_params(axis="y", labelsize=6.4, pad=2) + ax.set_xlim(0.45, 0.86) + ax.set_xlabel("AUROC for LSM >=9.5 kPa") + ax.text(0.0, -0.25, "Frozen predictors: age, sex, BMI, and CAP. Other-department validation excludes gastro/hepatobiliary sources.", transform=ax.transAxes, fontsize=6.7, color=COLORS["gray"]) + + fig.suptitle("Figure 1 | Proprietary clinical cohort architecture and baseline landscape", x=0.02, y=0.995, ha="left", fontsize=13, fontweight="bold") + save_figure(fig, MAIN / "Figure_1") + + +def draw_alluvial(ax: plt.Axes, matrix: pd.DataFrame) -> None: + order = ["LL", "HL", "LH", "HH"] + matrix = matrix.reindex(index=order, columns=order, fill_value=0) + total = matrix.to_numpy().sum() + left_totals = matrix.sum(axis=1).to_numpy() + right_totals = matrix.sum(axis=0).to_numpy() + gap = 0.025 + usable = 0.90 - gap * (len(order) - 1) + + def spans(totals: np.ndarray) -> dict[str, tuple[float, float]]: + cursor = 0.05 + out = {} + for st, n in zip(order, totals): + h = usable * n / total + out[st] = (cursor, cursor + h) + cursor += h + gap + return out + + left = spans(left_totals) + right = spans(right_totals) + left_cursor = {k: v[0] for k, v in left.items()} + right_cursor = {k: v[0] for k, v in right.items()} + x0, x1, node_w = 0.17, 0.82, 0.035 + + for a in order: + for b in order: + n = matrix.loc[a, b] + if n <= 0: + continue + h = usable * n / total + y0a, y0b = left_cursor[a], left_cursor[a] + h + y1a, y1b = right_cursor[b], right_cursor[b] + h + left_cursor[a] += h + right_cursor[b] += h + verts = [ + (x0 + node_w, y0a), + (0.43, y0a), + (0.57, y1a), + (x1, y1a), + (x1, y1b), + (0.57, y1b), + (0.43, y0b), + (x0 + node_w, y0b), + (x0 + node_w, y0a), + ] + codes = [MplPath.MOVETO, MplPath.CURVE4, MplPath.CURVE4, MplPath.CURVE4, MplPath.LINETO, MplPath.CURVE4, MplPath.CURVE4, MplPath.CURVE4, MplPath.CLOSEPOLY] + ax.add_patch(PathPatch(MplPath(verts, codes), facecolor=STATE_COLORS[a], edgecolor="none", alpha=0.40)) + + for st in order: + for x, mapping, totals in [(x0, left, left_totals), (x1, right, right_totals)]: + y0, y1 = mapping[st] + ax.add_patch(Rectangle((x, y0), node_w, y1 - y0, facecolor=STATE_COLORS[st], edgecolor="white", lw=0.6)) + y0, y1 = left[st] + ax.text(x0 - 0.015, (y0 + y1) / 2, f"{st} {matrix.loc[st].sum():,}", ha="right", va="center", fontsize=7) + y0, y1 = right[st] + ax.text(x1 + node_w + 0.015, (y0 + y1) / 2, f"{matrix[st].sum():,} {st}", ha="left", va="center", fontsize=7) + ax.text(x0, 0.985, "Baseline", ha="left", va="top", fontweight="bold", fontsize=7.5) + ax.text(x1 + node_w, 0.985, "Final", ha="right", va="top", fontweight="bold", fontsize=7.5) + ax.text(0.50, 0.015, f"n={total:,}; median follow-up 292 days", ha="center", fontsize=6.8, color=COLORS["gray"]) + ax.set_xlim(0, 1) + ax.set_ylim(0, 1) + ax.axis("off") + + +def serum_associations(score: pd.DataFrame) -> pd.DataFrame: + rows = [] + labels = { + "SDS_v0": "Composite SDS_v0", + "axis_ECM": "ECM retention axis", + "axis_cholestatic": "Cholestatic-support axis", + "axis_portal_synthetic": "Portal/synthetic deficit axis", + } + for col in labels: + or_, lo, hi, p = odds_ratio_glm(score, "advanced_fibrosis_by_LSM", col) + rows.append({"term": labels[col], "OR": or_, "ci_low": lo, "ci_high": hi, "p": p, "n": len(score)}) + return pd.DataFrame(rows) + + +def figure_main_2(longitudinal: pd.DataFrame, score: pd.DataFrame, serum_or: pd.DataFrame) -> None: + fig = plt.figure(figsize=(16.2, 11.0)) + gs = GridSpec(3, 12, figure=fig, height_ratios=[1.35, 3.3, 3.1], hspace=0.62, wspace=1.35) + + ax = fig.add_subplot(gs[0, :]) + ax.axis("off") + panel(ax, "A", "Operational bridge from tissue mechanism to measurable clinical states") + cards = [ + ("Imaging retention", "LSM >=9.5 kPa while CAP <280 dB/m\n885/8,142 baseline patients", COLORS["purple"]), + ("Serum imbalance", "ECM 50% + cholestatic support 25%\n+ inverse portal/synthetic reserve 25%", COLORS["red"]), + ("Imaging persistence", "Advanced LSM persists and falls <20%\nafter >=90 days", COLORS["gold"]), + ("Outcome boundary", "Imaging-defined progression/regression only\nno adjudicated readmission or treatment exposure", COLORS["gray"]), + ] + for i, (head, body, color) in enumerate(cards): + x, w = 0.025 + i * 0.245, 0.22 + ax.add_patch(FancyBboxPatch((x, 0.18), w, 0.62, boxstyle="round,pad=0.01,rounding_size=0.008", transform=ax.transAxes, fc="white", ec=color, lw=1.6)) + ax.text(x + 0.015, 0.69, head, transform=ax.transAxes, color=color, fontsize=8.5, fontweight="bold") + ax.text(x + 0.015, 0.43, body, transform=ax.transAxes, fontsize=7.1, va="center", linespacing=1.35) + if i < len(cards) - 1: + ax.annotate("", xy=(x + w + 0.021, 0.49), xytext=(x + w + 0.004, 0.49), xycoords=ax.transAxes, arrowprops=dict(arrowstyle="-|>", color=COLORS["gray"], lw=1.1)) + + ax = fig.add_subplot(gs[1:, :5]) + panel(ax, "B", "Four-state longitudinal flow in 772 repeat patients") + flow = pd.crosstab(longitudinal.state0, longitudinal.state1) + draw_alluvial(ax, flow) + + ax = fig.add_subplot(gs[1, 5:8]) + panel(ax, "C", "Imaging-defined longitudinal outcomes") + order = ["Persistent nonadvanced", "Threshold regression", "Persistent advanced", "Threshold progression"] + colors = [COLORS["teal"], COLORS["blue"], COLORS["red"], COLORS["orange"]] + counts = longitudinal.outcome.value_counts().reindex(order) + bars = ax.barh(np.arange(4)[::-1], counts.values, color=colors, height=0.65) + ax.set_yticks(np.arange(4)[::-1], ["Nonadvanced", "Regressed", "Advanced persistent", "Progressed"]) + ax.tick_params(axis="y", labelsize=6.3, pad=2) + ax.set_xlabel("Patients") + for bar, n in zip(bars, counts.values): + ax.text(n + 7, bar.get_y() + bar.get_height() / 2, f"{n:,} ({100*n/len(longitudinal):.1f}%)", va="center", fontsize=6.8) + ax.set_xlim(0, max(counts) * 1.27) + + ax = fig.add_subplot(gs[1, 8:12]) + panel(ax, "D", "CAP and LSM can change nonreciprocally") + cap_change = pd.cut(longitudinal.delta_CAP, [-np.inf, -20, 20, np.inf], labels=["CAP down >=20", "CAP stable", "CAP up >=20"]) + lsm_change = pd.cut(longitudinal.relative_LSM, [-np.inf, -0.20, 0.20, np.inf], labels=["LSM down >=20%", "LSM stable", "LSM up >=20%"]) + mat = pd.crosstab(cap_change, lsm_change).reindex(index=["CAP down >=20", "CAP stable", "CAP up >=20"], columns=["LSM down >=20%", "LSM stable", "LSM up >=20%"], fill_value=0) + sns.heatmap(mat, annot=True, fmt="d", cmap="Blues", cbar_kws={"label": "Patients"}, ax=ax, linewidths=1, linecolor="white") + ax.set_xlabel("") + ax.set_ylabel("") + ax.tick_params(axis="x", rotation=20) + ax.tick_params(axis="y", rotation=0) + subset = longitudinal[(longitudinal.CAP0 >= 0) & (longitudinal.LSM0 >= 9.5) & (longitudinal.delta_CAP <= -20)] + persistent = int(subset.advanced1.sum()) + ax.text(0.0, -0.30, f"Among baseline advanced cases with CAP falling >=20 dB/m, {persistent}/{len(subset)} ({100*persistent/len(subset):.1f}%) remained advanced.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + ax = fig.add_subplot(gs[2, 5:8]) + panel(ax, "E", "Imaging persistence by baseline state") + high = longitudinal.loc[longitudinal.advanced0 & longitudinal.state0.isin(["LH", "HH"])].copy() + summary = high.groupby("state0").agg(n=("patient", "size"), persistent=("advanced1", "mean"), resistant=("regression_resistant", "mean")).reindex(["LH", "HH"]) + x = np.arange(2) + ax.bar(x - 0.17, 100 * summary.persistent, width=0.34, color=COLORS["purple"], label="Persistent advanced") + ax.bar(x + 0.17, 100 * summary.resistant, width=0.34, color=COLORS["gold"], label="Persistent + <20% LSM fall") + ax.set_xticks(x, [f"{STATE_LABELS[s]}\nn={summary.loc[s, 'n']:,}" for s in summary.index]) + ax.set_ylabel("Patients (%)") + ax.set_ylim(0, 70) + ax.legend(frameon=False, loc="upper right") + for xi, st in enumerate(summary.index): + ax.text(xi - 0.17, 100 * summary.loc[st, "persistent"] + 2, f"{100*summary.loc[st, 'persistent']:.1f}", ha="center", fontsize=6.6) + ax.text(xi + 0.17, 100 * summary.loc[st, "resistant"] + 2, f"{100*summary.loc[st, 'resistant']:.1f}", ha="center", fontsize=6.6) + ax.text(0, -0.31, "Persistence is imaging-defined, not adjudicated biological regression or treatment failure.", transform=ax.transAxes, fontsize=6.7, color=COLORS["gray"]) + + ax = fig.add_subplot(gs[2, 8:12]) + panel(ax, "F", "Serum imbalance and advanced LSM") + short_terms = { + "Composite SDS_v0": "SDS_v0", + "ECM retention axis": "ECM", + "Cholestatic-support axis": "Cholestatic", + "Portal/synthetic deficit axis": "Portal/synthetic", + } + y = np.arange(len(serum_or))[::-1] + for yi, row in zip(y, serum_or.itertuples()): + ax.errorbar(row.OR, yi, xerr=[[row.OR - row.ci_low], [row.ci_high - row.OR]], fmt="o", color=COLORS["red"] if row.term == "Composite SDS_v0" else COLORS["blue"], capsize=3, lw=1.2, ms=5.5) + ax.text(row.ci_high + 0.15, yi, f"OR {row.OR:.2f} ({row.ci_low:.2f}-{row.ci_high:.2f}); P={row.p:.3f}", va="center", fontsize=6.5) + ax.axvline(1, color=COLORS["gray"], ls="--", lw=1) + ax.set_yticks(y, [short_terms[x] for x in serum_or.term]) + ax.tick_params(axis="y", labelsize=6.3, pad=2) + ax.set_xscale("log") + ax.set_xlim(0.22, 10.5) + ax.set_xlabel("Odds ratio per 1-SD increase for LSM >=9.5 kPa") + ax.text(0.0, -0.30, "n=46 complete cases; fixed outcome-independent weights; AUROC 0.688 (95% CI 0.497-0.862).", transform=ax.transAxes, fontsize=6.7, color=COLORS["gray"]) + + fig.suptitle("Figure 2 | Clinical persistence phenotype and longitudinal outcomes", x=0.02, y=0.995, ha="left", fontsize=13, fontweight="bold") + save_figure(fig, MAIN / "Figure_2") + + +def figure_ed1(index: pd.DataFrame, matched_index: pd.DataFrame) -> None: + fig, axes = plt.subplots(2, 2, figsize=(13.5, 9.2), gridspec_kw={"hspace": 0.52, "wspace": 0.38}) + ax = axes[0, 0] + panel(ax, "A", "Cohort attrition and denominator changes") + labels = ["Raw scans", "Technical QC", "Adult QC scans", "Adult index patients"] + values = [9703, 9644, 9562, 8142] + colors = [COLORS["blue"], COLORS["cyan"], COLORS["teal"], COLORS["gold"]] + y = np.arange(4)[::-1] + ax.barh(y, values, color=colors, height=0.68) + ax.set_yticks(y, labels) + ax.set_xlabel("Records") + ax.set_xlim(0, 10500) + for yi, v in zip(y, values): + ax.text(v + 120, yi, f"{v:,}", va="center", fontsize=7) + + ax = axes[0, 1] + panel(ax, "B", "Variable-specific 90-day linkage completeness") + variables = ["TG", "HDL", "UA", "FPG", "AST", "ALT", "GGT", "ALB", "PLT", "HA", "CIV", "LN", "PIIINP"] + completeness = matched_index[variables].notna().mean().sort_values() + ax.barh(np.arange(len(completeness)), 100 * completeness.values, color=[COLORS["teal"] if v > 0.1 else COLORS["gray"] for v in completeness.values], height=0.68) + ax.set_yticks(np.arange(len(completeness)), completeness.index) + ax.set_xlabel("Index patients with matched value (%)") + ax.set_xlim(0, max(20, 100 * completeness.max() * 1.15)) + for yi, v in enumerate(completeness.values): + ax.text(100 * v + 0.3, yi, f"{100*v:.1f}", va="center", fontsize=6.5) + + ax = axes[1, 0] + panel(ax, "C", "Absolute linkage offsets by analyte") + vars_off = ["TG", "HDL", "AST", "GGT", "PLT", "HA"] + data = [] + for var in vars_off: + vals = matched_index[f"{var}_off_days"].dropna().abs() + data.extend([(var, x) for x in vals]) + off = pd.DataFrame(data, columns=["analyte", "days"]) + sns.boxplot(data=off, x="analyte", y="days", color=COLORS["cyan"], width=0.58, fliersize=1.2, ax=ax) + ax.axhline(90, color=COLORS["red"], ls="--", lw=1) + ax.set_xlabel("") + ax.set_ylabel("Absolute offset (days)") + ax.set_ylim(-2, 95) + + ax = axes[1, 1] + panel(ax, "D", "Calendar drift in baseline stiffness prevalence") + yearly = index.groupby(index.scan_date.dt.year).agg(n=("advanced", "size"), advanced=("advanced", "mean"), high_cap=("cap280", "mean"), retention=("retention", "mean")).reset_index(names="year") + ax.plot(yearly.year, 100 * yearly.advanced, marker="o", color=COLORS["red"], label="LSM >=9.5") + ax.plot(yearly.year, 100 * yearly.high_cap, marker="s", color=COLORS["gold"], label="CAP >=280") + ax.plot(yearly.year, 100 * yearly.retention, marker="^", color=COLORS["purple"], label="Low-CAP/high-LSM") + for row in yearly.itertuples(): + ax.text(row.year, 100 * row.high_cap + 2.2, f"n={row.n:,}", ha="center", fontsize=6.5) + ax.set_xticks(yearly.year) + ax.set_ylabel("Index patients (%)") + ax.set_xlabel("Year") + ax.set_ylim(0, 58) + ax.legend(frameon=False, ncol=3, loc="upper left") + + fig.suptitle("Extended Data Figure 1 | Clinical data quality, linkage, and calendar structure", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_1") + + +def forest_effect_panel(ax: plt.Axes, data: pd.DataFrame, title: str, endpoint: str, color: str) -> None: + panel(ax, title[0], title[2:]) + d = data.loc[data.endpoint == endpoint].sort_values("beta_per_SD") + y = np.arange(len(d)) + ax.errorbar(d.beta_per_SD, y, xerr=[d.beta_per_SD - d.ci_low, d.ci_high - d.beta_per_SD], fmt="o", color=color, ecolor=color, capsize=2.5, ms=4.5) + ax.axvline(0, color=COLORS["gray"], ls="--", lw=0.9) + n_col = "n" if "n" in d.columns else "n_keys" + labels = [f"{a} n={int(n)}" for a, n in zip(d.analyte, d[n_col])] + ax.set_yticks(y, labels) + ax.set_xlabel("Adjusted effect per 1-SD analyte") + for yi, row in enumerate(d.itertuples()): + if row.q_value_BH < 0.05: + ax.text(row.ci_high, yi + 0.18, f"q={row.q_value_BH:.2g}", fontsize=6, color=color, ha="right") + + +def figure_ed2() -> None: + metabolic = pd.read_csv(CLIN / "metabolic_models.tsv", sep="\t") + lis = pd.read_csv(CLIN / "lis_models.tsv", sep="\t") + keep_met = metabolic.loc[(metabolic.q_value_BH < 0.10) | metabolic.analyte.isin(["TG", "HDL", "UA", "FPG"])].copy() + keep_lis = lis.loc[(lis.q_value_BH < 0.10) | lis.analyte.isin(["AST", "ALT", "GGT", "HA", "LN", "CIV", "PIIINP", "ALB", "PLT"])].copy() + fig, axes = plt.subplots(2, 2, figsize=(13.5, 10.3), gridspec_kw={"hspace": 0.48, "wspace": 0.42}) + forest_effect_panel(axes[0, 0], keep_met, "A Metabolic markers -> CAP", "CAP_dB_per_m", COLORS["gold"]) + forest_effect_panel(axes[0, 1], keep_met, "B Metabolic markers -> log-LSM", "log_LSM", COLORS["orange"]) + forest_effect_panel(axes[1, 0], keep_lis, "C LIS markers -> CAP", "CAP_dB_per_m", COLORS["blue"]) + forest_effect_panel(axes[1, 1], keep_lis, "D LIS markers -> log-LSM", "log_LSM", COLORS["red"]) + fig.suptitle("Extended Data Figure 2 | Adjusted metabolic and laboratory associations with CAP and LSM", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_2") + + +def figure_ed3(index_matched: pd.DataFrame) -> None: + fast = pd.read_csv(CLIN / "fast_score.tsv", sep="\t") + perf = pd.read_csv(CLIN / "fib4_ecm_performance.tsv", sep="\t") + cal = pd.read_csv(CLIN / "fib4_ecm_calibration.tsv", sep="\t") + fig, axes = plt.subplots(2, 2, figsize=(13.5, 9.6), gridspec_kw={"hspace": 0.52, "wspace": 0.42}) + + ax = axes[0, 0] + panel(ax, "A", "FAST distribution in CAP >=248 screening context") + d = fast.loc[fast.CAP_steatotic_phenotype] + ax.hist(d.FAST, bins=np.linspace(0, 1, 31), color=COLORS["teal"], edgecolor="white") + ax.axvline(0.35, color=COLORS["gold"], ls="--", lw=1.2) + ax.axvline(0.67, color=COLORS["red"], ls="--", lw=1.2) + ax.set_xlabel("FAST score") + ax.set_ylabel("Patients") + ax.text(0.03, 0.94, "n=286", transform=ax.transAxes, va="top", fontweight="bold") + + ax = axes[0, 1] + panel(ax, "B", "FAST varies across CAP-LSM states (descriptive)") + d = fast.copy() + d["state"] = state_code(d.CAP, d.LSM) + sns.boxplot(data=d, x="state", y="FAST", order=["LL", "HL", "LH", "HH"], palette=STATE_COLORS, width=0.62, fliersize=1.5, ax=ax) + ax.set_xlabel("CAP-LSM state") + ax.set_ylabel("FAST") + + ax = axes[1, 0] + panel(ax, "C", "Observed advanced-LSM fraction across score quartiles") + for score, color, marker in [("FIB4", COLORS["blue"], "o"), ("ECM4", COLORS["red"], "s")]: + q = cal.loc[cal.score == score].reset_index(drop=True) + x = np.arange(1, 5) + observed = q["observed_fraction_LSM_ge9.5"] + ax.errorbar(x, 100 * observed, yerr=[100 * (observed - q.ci_low), 100 * (q.ci_high - observed)], marker=marker, color=color, capsize=3, label=score) + ax.set_xticks([1, 2, 3, 4], ["Q1", "Q2", "Q3", "Q4"]) + ax.set_xlabel("Score quartile") + ax.set_ylabel("LSM >=9.5 kPa (%)") + ax.set_ylim(0, 85) + ax.legend(frameon=False) + + ax = axes[1, 1] + panel(ax, "D", "Imaging-reference discrimination remains imprecise") + auc = perf.loc[perf.metric == "AUROC_vs_LSM_ge9.5"].copy().iloc[::-1] + y = np.arange(len(auc)) + ax.errorbar(auc.estimate, y, xerr=[auc.estimate - auc.ci_low, auc.ci_high - auc.estimate], fmt="o", color=COLORS["blue"], capsize=3) + ax.axvline(0.5, color=COLORS["gray"], ls="--", lw=1) + ax.set_yticks(y, [f"{a} n={int(n)}" for a, n in zip(auc.analysis, auc.n)]) + ax.set_xlim(0.42, 1.0) + ax.set_xlabel("AUROC vs LSM >=9.5") + ax.text(0, -0.24, "FAST is not independently validated here because LSM and CAP are components of FAST.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + fig.suptitle("Extended Data Figure 3 | FAST, FIB-4, and ECM4 clinical calibration", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_3") + + +def figure_ed4() -> None: + sens = pd.read_csv(DYN / "S5_clinical_history_gain/threshold_sensitivity.tsv", sep="\t") + trans = pd.read_csv(DYN / "S3_clinical_multistate/transition_matrix.tsv", sep="\t") + curves = pd.read_csv(DYN / "S3_clinical_multistate/branch_prediction_curves.tsv", sep="\t") + branch = pd.read_csv(DYN / "S3_clinical_multistate/branch_model_summary.tsv", sep="\t") + fig, axes = plt.subplots(2, 2, figsize=(13.5, 9.6), gridspec_kw={"hspace": 0.52, "wspace": 0.40}) + + ax = axes[0, 0] + panel(ax, "A", "History-gain threshold landscape") + piv = sens.pivot(index="lsm_cut", columns="cap_cut", values="log_loss_gain").sort_index(ascending=False) + sns.heatmap(piv, cmap="RdBu_r", center=0, annot=True, fmt=".3f", linewidths=1, linecolor="white", cbar_kws={"label": "Held-out log-loss gain"}, ax=ax) + ax.set_xlabel("CAP threshold (dB/m)") + ax.set_ylabel("LSM threshold (kPa)") + cap_cols = list(piv.columns) + lsm_rows = list(piv.index) + if 280 in cap_cols and 9.5 in lsm_rows: + ax.add_patch(Rectangle((cap_cols.index(280), lsm_rows.index(9.5)), 1, 1, fill=False, ec=COLORS["dark"], lw=2.2)) + + ax = axes[0, 1] + panel(ax, "B", "Prespecified and exploratory uncertainty") + d = sens.loc[((sens.cap_cut == 280) & (sens.lsm_cut == 9.5)) | ((sens.lsm_cut == 12.0) & sens.log_loss_gain_ci_low.notna())].copy() + d["label"] = np.where(d.lsm_cut == 9.5, "Prespecified CAP280 / LSM9.5", "Exploratory CAP" + d.cap_cut.astype(int).astype(str) + " / LSM12") + d = d.sort_values(["lsm_cut", "cap_cut"]) + y = np.arange(len(d))[::-1] + for yi, row in zip(y, d.itertuples()): + color = COLORS["red"] if row.lsm_cut == 9.5 else COLORS["blue"] + ax.errorbar(row.log_loss_gain, yi, xerr=[[row.log_loss_gain - row.log_loss_gain_ci_low], [row.log_loss_gain_ci_high - row.log_loss_gain]], fmt="o", color=color, capsize=3) + ax.text(row.log_loss_gain_ci_high + 0.004, yi, f"Pperm={row.history_permutation_p:.3f}", va="center", fontsize=6.5) + ax.axvline(0, color=COLORS["gray"], ls="--", lw=1) + ax.set_yticks(y, d.label) + ax.set_xlabel("History-model log-loss gain") + ax.text(0, -0.23, "LSM12 results follow a 15-threshold search and remain hypothesis-generating.", transform=ax.transAxes, fontsize=6.8, color=COLORS["gray"]) + + ax = axes[1, 0] + panel(ax, "C", "Four-state transition probabilities at >=90 days") + t = trans.loc[trans.min_interval_days == 90].pivot(index="from_state", columns="to_state", values="row_probability") + order = ["LL", "HL", "LH", "HH"] + t = t.reindex(index=order, columns=order) + sns.heatmap(100 * t, cmap="YlGnBu", annot=True, fmt=".1f", linewidths=1, linecolor="white", cbar_kws={"label": "Row probability (%)"}, ax=ax) + ax.set_xlabel("Next state") + ax.set_ylabel("Current state") + + ax = axes[1, 1] + panel(ax, "D", "Primary and lag-adjusted CAP-LSM branches") + for model, ls in [("branch_primary", "-"), ("branch_lag_adjusted", "--")]: + for direction, color in [("up", COLORS["red"]), ("down", COLORS["blue"] )]: + d = curves.loc[(curves.model == model) & (curves.direction == direction)].sort_values("CAP") + ax.plot(d.CAP, d.pred_LSM, color=color, ls=ls, lw=1.5, label=f"{model.replace('branch_', '')}: CAP {direction}") + ax.fill_between(d.CAP, d.ci_low, d.ci_high, color=color, alpha=0.08) + ax.set_xlabel("CAP (dB/m)") + ax.set_ylabel("Predicted LSM (kPa)") + ax.legend(frameon=False, fontsize=6.4, ncol=2) + txt = " | ".join([f"{r.model.replace('branch_', '')}: joint P={r.joint_direction_p:.3g}" for r in branch.itertuples()]) + ax.text(0, -0.23, txt, transform=ax.transAxes, fontsize=6.6, color=COLORS["gray"]) + + fig.suptitle("Extended Data Figure 4 | Multistate dynamics, threshold sensitivity, and branch asymmetry", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_4") + + +def figure_ed5(index: pd.DataFrame, longitudinal: pd.DataFrame) -> None: + fig, axes = plt.subplots(2, 2, figsize=(13.5, 9.5), gridspec_kw={"hspace": 0.52, "wspace": 0.40}) + ax = axes[0, 0] + panel(ax, "A", "Follow-up interval distribution") + ax.hist(longitudinal.followup_days, bins=35, color=COLORS["blue"], edgecolor="white") + ax.axvline(longitudinal.followup_days.median(), color=COLORS["red"], ls="--", lw=1.2) + ax.set_xlabel("First-to-last interval (days)") + ax.set_ylabel("Patients") + ax.text(0.98, 0.94, f"median {longitudinal.followup_days.median():.0f} days\nn={len(longitudinal):,}", transform=ax.transAxes, ha="right", va="top", fontsize=7) + + ax = axes[0, 1] + panel(ax, "B", "Baseline versus final LSM") + ax.scatter(longitudinal.LSM0, longitudinal.LSM1, s=8, alpha=0.30, color=COLORS["blue"], edgecolor="none") + lim = [2.5, 33] + ax.plot(lim, lim, color=COLORS["gray"], ls="--", lw=1) + ax.axvline(9.5, color=COLORS["red"], ls=":", lw=1) + ax.axhline(9.5, color=COLORS["red"], ls=":", lw=1) + ax.set_xlim(lim) + ax.set_ylim(lim) + ax.set_xlabel("Baseline LSM (kPa)") + ax.set_ylabel("Final LSM (kPa)") + + ax = axes[1, 0] + panel(ax, "C", "Relative LSM change by baseline state") + sns.violinplot(data=longitudinal, x="state0", y="relative_LSM", order=["LL", "HL", "LH", "HH"], palette=STATE_COLORS, inner="quartile", cut=0, linewidth=0.8, ax=ax) + ax.axhline(0, color=COLORS["gray"], lw=0.8) + ax.axhline(-0.2, color=COLORS["blue"], ls="--", lw=0.9) + ax.axhline(0.2, color=COLORS["red"], ls="--", lw=0.9) + ax.set_ylim(-1.0, 2.5) + ax.set_xlabel("Baseline CAP-LSM state") + ax.set_ylabel("Relative LSM change") + + ax = axes[1, 1] + panel(ax, "D", "Longitudinal outcomes by baseline era") + tab = pd.crosstab(longitudinal.baseline_era, longitudinal.outcome).reindex(columns=["Persistent nonadvanced", "Threshold regression", "Persistent advanced", "Threshold progression"], fill_value=0) + pct = tab.div(tab.sum(axis=1), axis=0) * 100 + bottom = np.zeros(len(pct)) + colors = [COLORS["teal"], COLORS["blue"], COLORS["red"], COLORS["orange"]] + for col, color in zip(pct.columns, colors): + ax.bar(pct.index, pct[col], bottom=bottom, color=color, label=col, width=0.58, edgecolor="white") + bottom += pct[col].to_numpy() + for i, era in enumerate(pct.index): + ax.text(i, 102, f"n={tab.loc[era].sum():,}", ha="center", fontsize=6.8) + ax.set_ylim(0, 109) + ax.set_ylabel("Patients (%)") + ax.legend(frameon=False, fontsize=6.3, loc="lower center", bbox_to_anchor=(0.5, -0.32), ncol=2) + + fig.suptitle("Extended Data Figure 5 | Longitudinal distributions and temporal robustness", x=0.02, y=0.995, ha="left", fontsize=12.5, fontweight="bold") + save_figure(fig, ED / "Extended_Data_Figure_5") + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--clinical-input-dir", type=Path, default=CLIN) + parser.add_argument("--dynamics-input-dir", type=Path, default=DYN) + parser.add_argument("--output-dir", type=Path, default=OUTPUT_ROOT) + return parser.parse_args() + + +def main() -> None: + global CLIN, DYN, OUTPUT_ROOT, TABLES, MAIN, ED, LOGS + args = parse_args() + CLIN, DYN, OUTPUT_ROOT = args.clinical_input_dir, args.dynamics_input_dir, args.output_dir + TABLES = OUTPUT_ROOT / "source_tables" + MAIN = OUTPUT_ROOT / "main_figures" + ED = OUTPUT_ROOT / "extended_data_figures" + LOGS = OUTPUT_ROOT / "logs" + for folder in [TABLES, MAIN, ED, LOGS]: + folder.mkdir(parents=True, exist_ok=True) + elasto = pd.read_parquet(CLIN / "elasto_clean_full.parquet") + elasto = elasto.loc[elasto.adult_at_scan].copy().sort_values(["medical_record_hash", "scan_timestamp"]) + index = elasto.groupby("medical_record_hash", as_index=False).first() + index["male"] = index.sex.eq("M") + index["advanced"] = index.advanced_fibrosis_lsm_ge9_5.astype(bool) + index["cap248"] = index.CAP.ge(248) + index["cap280"] = index.CAP.ge(280) + index["f3"] = index.fibrosis_stage.eq("F3") + index["f4"] = index.fibrosis_stage.eq("F4") + index["gi"] = index.department.fillna("").str.contains("消化|肝胆") + index["state"] = state_code(index.CAP, index.LSM) + index["retention"] = index.state.eq("LH") + + matched = pd.read_parquet(CLIN / "matched_90d.parquet") + matched_index = index[["scan_hash"]].merge(matched, on="scan_hash", how="left", suffixes=("", "_matched")) + etiology = pd.read_csv(CLIN / "etiology_summary.tsv", sep="\t") + score = pd.read_csv(CLIN / "serum_decodable_state_score.tsv", sep="\t") + + baseline = baseline_table(index) + validation = validation_analysis(index) + longitudinal = build_longitudinal(elasto) + serum_or = serum_associations(score) + + baseline.to_csv(TABLES / "Table1_baseline_8142.tsv", sep="\t", index=False) + validation.to_csv(TABLES / "clinical_validation_metrics.tsv", sep="\t", index=False) + pd.crosstab(longitudinal.state0, longitudinal.state1).to_csv(TABLES / "longitudinal_state_flow.tsv", sep="\t") + longitudinal.outcome.value_counts().rename_axis("outcome").reset_index(name="n").to_csv(TABLES / "longitudinal_outcomes.tsv", sep="\t", index=False) + serum_or.to_csv(TABLES / "serum_imbalance_associations.tsv", sep="\t", index=False) + + summary = { + "cohort": { + "raw_scans": 9703, + "technical_qc_scans": 9644, + "adult_qc_scans": int(len(elasto)), + "adult_index_patients": int(len(index)), + "advanced_lsm_n": int(index.advanced.sum()), + "advanced_lsm_fraction": float(index.advanced.mean()), + "retention_phenotype_n": int(index.retention.sum()), + }, + "longitudinal": { + "n": int(len(longitudinal)), + "median_followup_days": float(longitudinal.followup_days.median()), + "outcomes": {k: int(v) for k, v in longitudinal.outcome.value_counts().items()}, + "regression_resistant_n": int(longitudinal.regression_resistant.sum()), + }, + "ethics": "approval number, approval date, committee, and consent-waiver status pending author input", + "clinical_event_boundary": "readmission, decompensation, mortality, transplant, treatment exposure, and prescription outcomes not present in current source files", + } + (TABLES / "clinical_analysis_summary.json").write_text(json.dumps(summary, ensure_ascii=False, indent=2), encoding="utf-8") + + figure_main_1(index, baseline, etiology, validation) + figure_main_2(longitudinal, score, serum_or) + figure_ed1(index, matched_index) + figure_ed2() + figure_ed3(matched_index) + figure_ed4() + figure_ed5(index, longitudinal) + + log = { + "script": str(SCRIPT), + "inputs": {"clinical": str(CLIN), "dynamics": str(DYN)}, + "main_figures": sorted(str(p) for p in MAIN.glob("*.png")), + "extended_figures": sorted(str(p) for p in ED.glob("*.png")), + "tables": sorted(str(p) for p in TABLES.glob("*")), + } + (LOGS / "rebuild_clinical_visuals_manifest.json").write_text(json.dumps(log, ensure_ascii=False, indent=2), encoding="utf-8") + print(json.dumps(summary, ensure_ascii=False, indent=2)) + + +if __name__ == "__main__": + main() diff --git a/code/human_hsc/GSE244832_hsc_donor_edger.R b/code/human_hsc/GSE244832_hsc_donor_edger.R new file mode 100644 index 0000000..1367a38 --- /dev/null +++ b/code/human_hsc/GSE244832_hsc_donor_edger.R @@ -0,0 +1,75 @@ +#!/usr/bin/env Rscript +suppressPackageStartupMessages({ + library(data.table) + library(edgeR) +}) + +args <- commandArgs(trailingOnly = TRUE) +arg_value <- function(flag, default) { + index <- match(flag, args) + if (!is.na(index) && index < length(args)) args[[index + 1L]] else default +} +repo_root <- Sys.getenv("PATHONICHE_REPO", ".") +input <- arg_value("--input-dir", file.path(repo_root, "work/GSE244832_hsc_pseudobulk")) +out <- arg_value("--output-dir", file.path(repo_root, "results/GSE244832_hsc_donor")) +dir.create(out, recursive = TRUE, showWarnings = FALSE) + +raw <- fread(file.path(input, "hsc_pseudobulk_counts.tsv")) +genes <- make.unique(raw$gene) +counts <- as.matrix(raw[, -1]) +rownames(counts) <- genes +meta <- fread(file.path(input, "donor_metadata.tsv")) +stopifnot(identical(colnames(counts), paste0("donor_", meta$donor_index))) + +label_sets <- list(metadata = meta$condition) +supplement <- meta$condition +supplement[meta$donor == "JB321"] <- "NAFL" +supplement[meta$donor == "JB337"] <- "NASH" +label_sets$supplement_swap <- supplement + +all_summaries <- list() +for (label_name in names(label_sets)) { + group <- factor(label_sets[[label_name]], levels = c("NORMAL", "NAFL", "NASH")) + design <- model.matrix(~ 0 + group) + colnames(design) <- levels(group) + model_meta <- copy(meta) + model_meta[, model_condition := as.character(group)] + y <- DGEList(counts = counts, samples = model_meta) + keep <- filterByExpr(y, group = group, min.count = 10, min.total.count = 30) + y <- y[keep, , keep.lib.sizes = FALSE] + y <- calcNormFactors(y) + y <- estimateDisp(y, design, robust = TRUE) + fit <- glmQLFit(y, design, robust = TRUE) + + contrasts <- list( + MASH_vs_nonactivated = makeContrasts(NASH - (NORMAL + NAFL) / 2, levels = design), + MASH_vs_NORMAL = makeContrasts(NASH - NORMAL, levels = design), + MASL_vs_NORMAL = makeContrasts(NAFL - NORMAL, levels = design) + ) + for (name in names(contrasts)) { + test <- glmQLFTest(fit, contrast = contrasts[[name]]) + table <- topTags(test, n = Inf, sort.by = "PValue")$table + table$gene <- rownames(table) + fwrite(table, file.path(out, paste0(label_name, "_", name, "_edgeR.tsv")), sep = "\t") + key <- paste(label_name, name, sep = "__") + all_summaries[[key]] <- data.table( + label_set = label_name, + contrast = name, + tested_genes = nrow(table), + fdr_005 = sum(table$FDR < 0.05), + fdr_010 = sum(table$FDR < 0.10), + fdr_010_lfc_05 = sum(table$FDR < 0.10 & abs(table$logFC) >= 0.5) + ) + } + if (label_name == "metadata") { + cpm_table <- as.data.table(cpm(y, log = TRUE, prior.count = 1), keep.rownames = "gene") + fwrite(cpm_table, file.path(out, "hsc_logCPM.tsv.gz"), sep = "\t") + } + fwrite(as.data.table(y$samples), file.path(out, paste0(label_name, "_model_sample_metadata.tsv")), sep = "\t") + saveRDS(list(y = y, fit = fit, design = design, contrasts = contrasts), + file.path(out, paste0(label_name, "_edgeR_model.rds")), compress = "xz") +} + +summary_table <- rbindlist(all_summaries) +fwrite(summary_table, file.path(out, "contrast_summary.tsv"), sep = "\t") +print(summary_table) diff --git a/code/human_hsc/GSE244832_integrate_retention_candidates.py b/code/human_hsc/GSE244832_integrate_retention_candidates.py new file mode 100644 index 0000000..7a61572 --- /dev/null +++ b/code/human_hsc/GSE244832_integrate_retention_candidates.py @@ -0,0 +1,123 @@ +#!/usr/bin/env python3 +"""Integrate donor HSC RNA, published HSC ATAC, and dynamic regression fates.""" + +import argparse +from io import BytesIO +from pathlib import Path +from zipfile import ZipFile + +import numpy as np +import pandas as pd +from openpyxl import load_workbook + + +REPO_ROOT = Path(__file__).resolve().parents[2] +EDGE = REPO_ROOT / "results/GSE244832_hsc_donor" +DYNAMIC = REPO_ROOT / "results/GSE295293_dynamic_regression/gene_fates_HSC_Mesenchymal.tsv.gz" +SUPPLEMENT = REPO_ROOT / "data/raw_external/GSE244832/ScienceDirect_files_22Apr2025_06-13-10.681.zip" +OUT = EDGE / "integrated_retention_candidates.tsv" + +FUNCTIONAL_SUPPORT = { + "SERPINE1": "human spheroid knockdown; HSC-specific mouse knockout/pharmacology", + "SPON1": "human HSC knockdown validation in source study", + "LTBP2": "human HSC knockdown validation in source study", + "EFEMP1": "human HSC knockdown validation in source study", + "GAS7": "human HSC knockdown validation in source study", + "RUNX1": "source-study promoter/motif and perturbation support", + "RUNX2": "source-study promoter/motif and perturbation support", +} + + +def read_source_table() -> pd.DataFrame: + with ZipFile(SUPPLEMENT) as archive: + payload = archive.read("1-s2.0-S0168827824026679-mmc14.xlsx") + sheet = load_workbook(BytesIO(payload), read_only=True, data_only=True).active + rows = list(sheet.iter_rows(min_row=8, values_only=True)) + header = [str(value) if value is not None else f"empty_{index}" for index, value in enumerate(rows[0])] + result = pd.DataFrame(rows[1:], columns=header) + result = result.rename(columns={result.columns[0]: "gene"}) + return result[result.gene.notna()].copy() + + +def read_edge(label: str) -> pd.DataFrame: + data = pd.read_csv(EDGE / f"{label}_MASH_vs_nonactivated_edgeR.tsv", sep="\t") + data["gene_upper"] = data.gene.str.upper() + return data[["gene_upper", "logFC", "PValue", "FDR"]].rename( + columns={column: f"{label}_{column}" for column in ("logFC", "PValue", "FDR")} + ) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--edge-dir", type=Path, default=EDGE) + parser.add_argument("--dynamic-fates", type=Path, default=DYNAMIC) + parser.add_argument("--source-supplement", type=Path, default=SUPPLEMENT) + parser.add_argument("--output", type=Path, default=None) + return parser.parse_args() + + +def main() -> None: + global EDGE, DYNAMIC, SUPPLEMENT, OUT + args = parse_args() + EDGE, DYNAMIC, SUPPLEMENT = args.edge_dir, args.dynamic_fates, args.source_supplement + OUT = args.output or EDGE / "integrated_retention_candidates.tsv" + OUT.parent.mkdir(parents=True, exist_ok=True) + source = read_source_table() + source["gene_upper"] = source.gene.astype(str).str.upper() + source = source.rename(columns={ + "avg_log2FC_AvsQ_ATAC": "author_AvsQ_ATAC_logFC", + "avg_log2FC_MASHvsNA_ATAC": "author_MASH_ATAC_logFC", + "avg_log2FC_AvsQ_RNA": "author_AvsQ_RNA_logFC", + "avg_log2FC_MASHvsNA_RNA": "author_MASH_RNA_logFC", + "sum_sig": "author_sum_sig", + }) + source = source[[ + "gene_upper", "author_AvsQ_ATAC_logFC", "author_MASH_ATAC_logFC", + "author_AvsQ_RNA_logFC", "author_MASH_RNA_logFC", "author_sum_sig", + ]].drop_duplicates("gene_upper") + + dynamic = pd.read_csv(DYNAMIC, sep="\t") + dynamic["gene_upper"] = dynamic.gene.str.upper() + dynamic = dynamic.drop(columns="gene").rename(columns={column: f"mouse_{column}" for column in dynamic.columns if column != "gene_upper"}) + + merged = read_edge("metadata").merge(read_edge("supplement_swap"), on="gene_upper", how="outer") + merged = merged.merge(source, on="gene_upper", how="left").merge(dynamic, on="gene_upper", how="left") + merged["human_positive_both"] = (merged.metadata_logFC > 0) & (merged.supplement_swap_logFC > 0) + merged["human_nominal_both"] = (merged.metadata_PValue < 0.05) & (merged.supplement_swap_PValue < 0.05) + merged["human_fdr_any_010"] = np.minimum(merged.metadata_FDR, merged.supplement_swap_FDR) < 0.10 + merged["author_four_way"] = merged.author_sum_sig.eq(4) + merged["mouse_positive_residual"] = (merged.mouse_residual_logFC > 0) & (merged.mouse_residual_FDR < 0.10) + merged["mouse_persistent"] = merged.mouse_fate.eq("persistent") + merged["cross_species_direction"] = merged.human_positive_both & (merged.mouse_progression_logFC > 0) + merged["functional_support"] = merged.gene_upper.map(FUNCTIONAL_SUPPORT).fillna("") + merged["evidence_score"] = ( + 2 * merged.human_nominal_both.astype(int) + + 2 * merged.mouse_persistent.astype(int) + + merged.human_fdr_any_010.astype(int) + + merged.author_four_way.astype(int) + + merged.mouse_positive_residual.astype(int) + + merged.cross_species_direction.astype(int) + + merged.functional_support.ne("").astype(int) + ) + merged["classification"] = np.select( + [ + merged.human_positive_both & (merged.mouse_progression_logFC < 0), + merged.mouse_persistent & merged.cross_species_direction & merged.author_four_way, + merged.mouse_positive_residual & merged.human_positive_both, + ], + ["cross_species_direction_conflict", "pathogenic_retention_candidate", "residual_state_candidate"], + default="insufficient_or_context_specific", + ) + merged = merged.sort_values(["evidence_score", "metadata_PValue"], ascending=[False, True]) + merged.to_csv(OUT, sep="\t", index=False) + columns = [ + "gene_upper", "evidence_score", "classification", "metadata_logFC", "metadata_FDR", + "supplement_swap_logFC", "supplement_swap_FDR", "mouse_progression_logFC", + "mouse_residual_logFC", "mouse_residual_FDR", "mouse_fate", "author_four_way", + "functional_support", + ] + print(merged[columns].head(40).to_string(index=False)) + + +if __name__ == "__main__": + main() diff --git a/code/human_hsc/GSE244832_prepare_hsc_map.py b/code/human_hsc/GSE244832_prepare_hsc_map.py new file mode 100644 index 0000000..1cc3e07 --- /dev/null +++ b/code/human_hsc/GSE244832_prepare_hsc_map.py @@ -0,0 +1,66 @@ +#!/usr/bin/env python3 +"""Prepare matrix-column annotations for streaming GSE244832 HSC pseudobulk.""" + +import argparse +from pathlib import Path + +import pandas as pd + + +REPO_ROOT = Path(__file__).resolve().parents[2] +SOURCE = REPO_ROOT / "data/raw_external/GSE244832" +OUT = REPO_ROOT / "work/GSE244832_hsc_pseudobulk" + +DONOR_ORDER = [ + "JB336", "JB288", "JB303", "JB317", "JB320", "JB289", "JB304", "JB318", "JB321", + "JB337", "JB305", "JB290", "JB319", "JB322", "JB338", "JB339", "JB340", "JB341", +] + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--source-dir", type=Path, default=SOURCE) + parser.add_argument("--output-dir", type=Path, default=OUT) + return parser.parse_args() + + +def main() -> None: + global SOURCE, OUT + args = parse_args() + SOURCE, OUT = args.source_dir, args.output_dir + OUT.mkdir(parents=True, exist_ok=True) + cells = pd.read_csv(SOURCE / "hLIVER_cells.csv", header=None, names=["cell"]) + metadata = pd.read_csv(SOURCE / "hLIVER_metadata.csv").rename(columns={"Unnamed: 0": "cell"}) + if not cells.cell.equals(metadata.cell): + raise ValueError("Matrix columns and metadata rows are not in identical cell order") + + observed = set(metadata["orig.ident"]) + if observed != set(DONOR_ORDER): + raise ValueError(f"Unexpected donor IDs: {sorted(observed ^ set(DONOR_ORDER))}") + donor_index = {donor: index for index, donor in enumerate(DONOR_ORDER)} + mapping = pd.DataFrame({ + "donor_index": metadata["orig.ident"].map(donor_index).astype(int), + "cluster": metadata["seurat_clusters"].astype(int), + }) + mapping.to_csv(OUT / "cell_map.tsv", sep="\t", header=False, index=False) + + donor_meta = ( + metadata[["orig.ident", "condition"]] + .drop_duplicates() + .set_index("orig.ident") + .loc[DONOR_ORDER] + .reset_index() + .rename(columns={"orig.ident": "donor"}) + ) + donor_meta.insert(0, "donor_index", range(len(donor_meta))) + hsc_counts = metadata.loc[metadata.seurat_clusters == 3, "orig.ident"].value_counts() + donor_meta["hsc_cells"] = donor_meta.donor.map(hsc_counts).fillna(0).astype(int) + donor_meta.to_csv(OUT / "donor_metadata.tsv", sep="\t", index=False) + + genes = pd.read_csv(SOURCE / "hLIVER_genes.csv", header=None, names=["gene"]) + genes.to_csv(OUT / "genes.tsv", sep="\t", header=False, index=False) + print(donor_meta.to_string(index=False)) + + +if __name__ == "__main__": + main() diff --git a/code/human_hsc/GSE244832_stream_hsc_pseudobulk.cpp b/code/human_hsc/GSE244832_stream_hsc_pseudobulk.cpp new file mode 100644 index 0000000..34568a4 --- /dev/null +++ b/code/human_hsc/GSE244832_stream_hsc_pseudobulk.cpp @@ -0,0 +1,107 @@ +#include +#include +#include +#include +#include +#include +#include +#include + +namespace { +constexpr int kDonors = 18; +constexpr int kHscCluster = 3; + +class FastInput { + public: + bool next_int(int& value) { + int c; + do { + c = read_char(); + if (c == EOF) return false; + } while (c < '0' || c > '9'); + value = 0; + do { + value = value * 10 + (c - '0'); + c = read_char(); + } while (c >= '0' && c <= '9'); + return true; + } + + private: + static constexpr size_t kBufferSize = 1 << 20; + std::array buffer_{}; + size_t position_ = 0; + size_t size_ = 0; + + int read_char() { + if (position_ == size_) { + size_ = std::fread(buffer_.data(), 1, buffer_.size(), stdin); + position_ = 0; + if (size_ == 0) return EOF; + } + return buffer_[position_++]; + } +}; +} // namespace + +int main(int argc, char** argv) { + if (argc != 5) { + std::cerr << "usage: stream_hsc cell_map.tsv genes.tsv counts.tsv metadata.tsv\n"; + return 2; + } + std::ifstream map_file(argv[1]); + std::vector donor_by_cell; + std::vector cluster_by_cell; + int donor = 0; + int cluster = 0; + while (map_file >> donor >> cluster) { + donor_by_cell.push_back(donor); + cluster_by_cell.push_back(cluster); + } + + std::ifstream gene_file(argv[2]); + std::vector genes; + std::string gene; + while (std::getline(gene_file, gene)) { + if (!gene.empty()) genes.push_back(gene); + } + const size_t n_genes = genes.size(); + std::vector counts(n_genes * kDonors, 0); + + FastInput input; + int gene_index = 0; + int cell_index = 0; + int count = 0; + std::uint64_t entries = 0; + while (input.next_int(gene_index) && input.next_int(cell_index) && input.next_int(count)) { + --gene_index; + --cell_index; + if (gene_index < 0 || static_cast(gene_index) >= n_genes || cell_index < 0 || + static_cast(cell_index) >= donor_by_cell.size()) { + std::cerr << "matrix index out of range at entry " << entries << "\n"; + return 3; + } + if (cluster_by_cell[cell_index] == kHscCluster) { + counts[static_cast(gene_index) * kDonors + donor_by_cell[cell_index]] += count; + } + ++entries; + } + + std::ofstream output(argv[3]); + output << "gene"; + for (int index = 0; index < kDonors; ++index) output << "\tdonor_" << index; + output << '\n'; + for (size_t gene_id = 0; gene_id < n_genes; ++gene_id) { + output << genes[gene_id]; + for (int index = 0; index < kDonors; ++index) { + output << '\t' << counts[gene_id * kDonors + index]; + } + output << '\n'; + } + + std::ofstream audit(argv[4]); + audit << "matrix_entries\t" << entries << "\n"; + audit << "matrix_cells\t" << donor_by_cell.size() << "\n"; + audit << "matrix_genes\t" << n_genes << "\n"; + return 0; +} diff --git a/code/macrophage/GSE261829_macrophage_resolution.R b/code/macrophage/GSE261829_macrophage_resolution.R new file mode 100644 index 0000000..d42bae6 --- /dev/null +++ b/code/macrophage/GSE261829_macrophage_resolution.R @@ -0,0 +1,147 @@ +#!/usr/bin/env Rscript +suppressPackageStartupMessages({ + library(Matrix) + library(data.table) + library(edgeR) +}) + +args <- commandArgs(trailingOnly = TRUE) +arg_value <- function(flag, default) { + index <- match(flag, args) + if (!is.na(index) && index < length(args)) args[[index + 1L]] else default +} +repo_root <- Sys.getenv("PATHONICHE_REPO", ".") +source <- arg_value("--source-rds", file.path(repo_root, "data/raw_external/GSE261829/GSE261829_npc_filtered.rds.gz")) +out <- arg_value("--output-dir", file.path(repo_root, "results/GSE261829_macrophage_resolution")) +dir.create(out, recursive = TRUE, showWarnings = FALSE) + +sample_map <- data.table( + orig.ident = paste0("NPC_", c(3084, 3025, 2999, 2891, 2744, 2722, 2527, 2525, 1215)), + condition = rep(c("control", "MASH", "regression"), each = 3), + replicate = rep(1:3, 3) +) +sample_map[, condition := factor(condition, levels = c("control", "MASH", "regression"))] + +object <- readRDS(gzcon(gzfile(source, "rb"))) +meta <- as.data.table(attr(object, "meta.data"), keep.rownames = "cell") +counts <- attr(attr(object, "assays")[[1]], "counts") +stopifnot(identical(colnames(counts), meta$cell)) +meta[, seurat_clusters := as.integer(as.character(seurat_clusters))] +meta <- merge(meta, sample_map, by = "orig.ident", all.x = TRUE, sort = FALSE) +stopifnot(!anyNA(meta$condition)) + +cluster_map <- data.table( + seurat_clusters = c(0L, 8L, 1L, 2L, 5L, 15L), + macrophage_state = c("EmKC", "EmKC", "MoKC", "LAM", "Ly6chi_RM", "Mac1") +) +meta <- merge(meta, cluster_map, by = "seurat_clusters", all.x = TRUE, sort = FALSE) +meta[, matrix_column := match(cell, colnames(counts))] + +composition <- meta[!is.na(macrophage_state), .(n_cells = .N), by = .(orig.ident, macrophage_state)] +composition <- merge( + CJ(orig.ident = sample_map$orig.ident, macrophage_state = unique(cluster_map$macrophage_state)), + composition, by = c("orig.ident", "macrophage_state"), all.x = TRUE +) +composition[is.na(n_cells), n_cells := 0L] +composition <- merge(composition, sample_map, by = "orig.ident") +totals <- composition[, .(macrophage_cells = sum(n_cells)), by = .(orig.ident, condition, replicate)] +composition <- merge(composition, totals, by = c("orig.ident", "condition", "replicate")) +composition[, fraction := n_cells / macrophage_cells] +fwrite(composition, file.path(out, "donor_macrophage_composition.tsv"), sep = "\t") + +aggregate_state <- function(state_name, clusters) { + columns <- meta[seurat_clusters %in% clusters, matrix_column] + state_meta <- meta[seurat_clusters %in% clusters, .(matrix_column, orig.ident)] + result <- matrix(0, nrow = nrow(counts), ncol = nrow(sample_map), + dimnames = list(rownames(counts), sample_map$orig.ident)) + for (index in seq_len(nrow(sample_map))) { + selected <- state_meta[orig.ident == sample_map$orig.ident[index], matrix_column] + if (length(selected)) result[, index] <- Matrix::rowSums(counts[, selected, drop = FALSE]) + } + result +} + +run_dynamic <- function(state_name, clusters) { + pseudobulk <- aggregate_state(state_name, clusters) + group <- sample_map$condition + design <- model.matrix(~ 0 + group) + colnames(design) <- levels(group) + y <- DGEList(pseudobulk, samples = sample_map) + keep <- filterByExpr(y, group = group, min.count = 5, min.total.count = 15) + y <- y[keep, , keep.lib.sizes = FALSE] + y <- calcNormFactors(y) + y <- estimateDisp(y, design, robust = TRUE) + fit <- glmQLFit(y, design, robust = TRUE) + contrasts <- list( + progression = makeContrasts(MASH - control, levels = design), + regression = makeContrasts(regression - MASH, levels = design), + residual = makeContrasts(regression - control, levels = design) + ) + tables <- list() + for (name in names(contrasts)) { + tab <- topTags(glmQLFTest(fit, contrast = contrasts[[name]]), n = Inf, sort.by = "none")$table + tab$gene <- rownames(tab) + tables[[name]] <- as.data.table(tab) + } + merged <- merge(tables$progression[, .(gene, progression_logFC = logFC, progression_FDR = FDR)], + tables$regression[, .(gene, regression_logFC = logFC, regression_FDR = FDR)], by = "gene") + merged <- merge(merged, tables$residual[, .(gene, residual_logFC = logFC, residual_FDR = FDR)], by = "gene") + merged[, fate := fifelse( + progression_FDR < 0.10 & abs(progression_logFC) >= 0.5 & + sign(residual_logFC) == sign(progression_logFC) & residual_FDR < 0.10 & + abs(residual_logFC) >= 0.5 * abs(progression_logFC), "persistent", + fifelse(progression_FDR < 0.10 & abs(progression_logFC) >= 0.5 & + sign(regression_logFC) == -sign(progression_logFC) & + abs(regression_logFC) >= 0.5 * abs(progression_logFC), "reversed", "partial_or_other") + )] + fwrite(merged, file.path(out, paste0("gene_fates_", state_name, ".tsv.gz")), sep = "\t") + logcpm <- as.data.table(cpm(y, log = TRUE, prior.count = 1), keep.rownames = "gene") + fwrite(logcpm, file.path(out, paste0("logCPM_", state_name, ".tsv.gz")), sep = "\t") + list(y = y, fates = merged, logcpm = logcpm) +} + +lam <- run_dynamic("LAM", 2L) +all_macrophages <- run_dynamic("all_macrophages", c(0L, 8L, 1L, 2L, 5L, 15L)) + +modules <- list( + LAM_identity = c("Trem2", "Gpnmb", "Spp1", "Cd9", "Lpl", "Fabp5"), + collagen_resolution = c("Mmp9", "Mmp12", "Mmp13", "Mmp14", "Plau", "Ctsb", "Ctsd", "Axl", "Mertk"), + inflammatory = c("Il1b", "Tnf", "Nlrp3", "Ccl2", "Ccr2", "Ly6c2", "S100a8", "S100a9") +) +module_rows <- list() +for (state_name in c("LAM", "all_macrophages")) { + table <- if (state_name == "LAM") lam$logcpm else all_macrophages$logcpm + matrix_values <- as.matrix(table[, -1]) + rownames(matrix_values) <- table$gene + for (module_name in names(modules)) { + genes <- intersect(modules[[module_name]], rownames(matrix_values)) + score <- colMeans(matrix_values[genes, , drop = FALSE]) + module_rows[[paste(state_name, module_name)]] <- data.table( + state = state_name, module = module_name, orig.ident = colnames(matrix_values), score = score + ) + } +} +module_scores <- merge(rbindlist(module_rows), sample_map, by = "orig.ident") +fwrite(module_scores, file.path(out, "donor_module_scores.tsv"), sep = "\t") + +lam_fraction <- composition[macrophage_state == "LAM"] +observed <- mean(lam_fraction[condition == "regression", fraction]) - mean(lam_fraction[condition == "MASH", fraction]) +set.seed(20260711) +permuted <- replicate(10000, { + shuffled <- sample(lam_fraction$condition) + mean(lam_fraction$fraction[shuffled == "regression"]) - mean(lam_fraction$fraction[shuffled == "MASH"]) +}) +composition_test <- data.table( + contrast = "LAM fraction: regression - MASH", + effect = observed, + permutation_p_two_sided = (1 + sum(abs(permuted) >= abs(observed))) / (length(permuted) + 1) +) +fwrite(composition_test, file.path(out, "LAM_composition_permutation.tsv"), sep = "\t") + +priority <- c("Trem2", "Gpnmb", "Spp1", "Cd9", "Lpl", "Mmp9", "Mmp12", "Mmp13", "Mmp14", "Plau", "Axl", "Mertk") +priority_table <- lam$fates[gene %in% priority] +fwrite(priority_table, file.path(out, "LAM_priority_gene_fates.tsv"), sep = "\t") + +print(composition) +print(composition_test) +print(priority_table) diff --git a/code/mouse/GSE295293_dynamic_pseudobulk.R b/code/mouse/GSE295293_dynamic_pseudobulk.R new file mode 100644 index 0000000..d3994a5 --- /dev/null +++ b/code/mouse/GSE295293_dynamic_pseudobulk.R @@ -0,0 +1,102 @@ +suppressPackageStartupMessages({ + library(data.table) + library(edgeR) + library(jsonlite) +}) + +args <- commandArgs(trailingOnly = TRUE) +arg_value <- function(flag, default) { + index <- match(flag, args) + if (!is.na(index) && index < length(args)) args[[index + 1L]] else default +} +repo_root <- Sys.getenv("PATHONICHE_REPO", ".") +input_dir <- arg_value("--input-dir", file.path(repo_root, "work/GSE295293")) +output_dir <- arg_value("--output-dir", file.path(repo_root, "results/GSE295293_dynamic_regression")) +dir.create(output_dir, recursive = TRUE, showWarnings = FALSE) + +counts_file <- file.path(input_dir, "pseudobulk_counts.tsv.gz") +counts <- fread(cmd = paste("gzip -cd", shQuote(counts_file))) +genes <- counts[[1L]] +counts <- as.matrix(counts[, -1L]) +rownames(counts) <- genes +metadata <- fread(file.path(input_dir, "pseudobulk_metadata.tsv")) +metadata[, condition := factor(condition, levels = c("control", "fibrosis", "regression"))] + +cosine <- function(x, y) sum(x * y, na.rm = TRUE) / + sqrt(sum(x^2, na.rm = TRUE) * sum(y^2, na.rm = TRUE)) + +summary_rows <- list() +all_results <- list() + +for (ct in sort(unique(metadata$cell_type))) { + meta <- metadata[cell_type == ct] + if (any(table(meta$condition) < 2)) next + matrix <- counts[, meta$pseudobulk, drop = FALSE] + y <- DGEList(matrix) + design <- model.matrix(~ 0 + condition, data = meta) + colnames(design) <- sub("condition", "", colnames(design)) + keep <- filterByExpr(y, design) + y <- y[keep, , keep.lib.sizes = FALSE] + y <- calcNormFactors(y) + y <- estimateDisp(y, design, robust = TRUE) + fit <- glmQLFit(y, design, robust = TRUE) + contrasts <- list( + progression = makeContrasts(fibrosis - control, levels = design), + regression = makeContrasts(regression - fibrosis, levels = design), + residual = makeContrasts(regression - control, levels = design) + ) + tables <- lapply(names(contrasts), function(name) { + result <- topTags(glmQLFTest(fit, contrast = contrasts[[name]]), n = Inf, sort.by = "none")$table + data.table(gene = rownames(result), contrast = name, result) + }) + names(tables) <- names(contrasts) + combined <- rbindlist(tables) + fwrite(combined, file.path(output_dir, paste0("edgeR_", ct, ".tsv.gz")), sep = "\t") + + progression <- tables$progression[, .(gene, progression_logFC = logFC, progression_FDR = FDR)] + regression <- tables$regression[, .(gene, regression_logFC = logFC, regression_FDR = FDR)] + residual <- tables$residual[, .(gene, residual_logFC = logFC, residual_FDR = FDR)] + joint <- Reduce(function(x, z) merge(x, z, by = "gene"), list(progression, regression, residual)) + disease <- joint$progression_FDR < 0.10 & abs(joint$progression_logFC) >= 0.5 + reversed <- disease & sign(joint$regression_logFC) == -sign(joint$progression_logFC) & + abs(joint$regression_logFC) >= 0.5 * abs(joint$progression_logFC) + persistent <- disease & sign(joint$residual_logFC) == sign(joint$progression_logFC) & + joint$residual_FDR < 0.10 & abs(joint$residual_logFC) >= 0.5 * abs(joint$progression_logFC) + joint[, fate := fifelse(reversed, "reversed", + fifelse(persistent, "persistent", "partial_or_other"))] + fwrite(joint[order(progression_FDR)], file.path(output_dir, paste0("gene_fates_", ct, ".tsv.gz")), sep = "\t") + + summary_rows[[ct]] <- data.table( + cell_type = ct, + n_samples = nrow(meta), + n_genes = nrow(joint), + progression_FDR05 = sum(joint$progression_FDR < 0.05), + regression_FDR05 = sum(joint$regression_FDR < 0.05), + residual_FDR05 = sum(joint$residual_FDR < 0.05), + disease_genes_FDR10_FC05 = sum(disease), + reversed_genes = sum(reversed), + persistent_genes = sum(persistent), + recovery_fraction = ifelse(sum(disease) > 0, sum(reversed) / sum(disease), NA_real_), + persistence_fraction = ifelse(sum(disease) > 0, sum(persistent) / sum(disease), NA_real_), + regression_vs_negative_progression_spearman = cor(joint$regression_logFC, + -joint$progression_logFC, + method = "spearman"), + regression_vs_negative_progression_cosine = cosine(joint$regression_logFC, + -joint$progression_logFC), + nonreciprocity_norm = sqrt(sum((joint$progression_logFC + joint$regression_logFC)^2)) / + (sqrt(sum(joint$progression_logFC^2)) + sqrt(sum(joint$regression_logFC^2))) + ) +} + +summary <- rbindlist(summary_rows, fill = TRUE) +fwrite(summary, file.path(output_dir, "celltype_dynamic_summary.tsv"), sep = "\t") +write_json(list( + analysis = "donor-level pseudobulk progression-regression geometry", + statistical_unit = "mouse", + progression = "fibrosis minus control", + regression = "regression minus fibrosis", + residual = "regression minus control", + caveat = "nonreciprocity requires independent replication and a label-aware null; cells are not replicates", + cell_types = nrow(summary) +), file.path(output_dir, "dynamic_analysis_manifest.json"), pretty = TRUE, auto_unbox = TRUE) +print(summary) diff --git a/code/mouse/GSE295293_prepare_pseudobulk.py b/code/mouse/GSE295293_prepare_pseudobulk.py new file mode 100644 index 0000000..b4c7f51 --- /dev/null +++ b/code/mouse/GSE295293_prepare_pseudobulk.py @@ -0,0 +1,195 @@ +#!/usr/bin/env python3 +"""QC, broad cell typing, and donor-level pseudobulk for GSE295293.""" + +from __future__ import annotations + +import argparse +import gzip +import re +import tarfile +from pathlib import Path + +import anndata as ad +import numpy as np +import pandas as pd +import scanpy as sc +from scipy.io import mmread + + +REPO_ROOT = Path(__file__).resolve().parents[2] +ARCHIVE = REPO_ROOT / "data/raw_external/GSE295293/GSE295293_RAW.tar" +WORK = REPO_ROOT / "work/GSE295293" +OUT = REPO_ROOT / "results/GSE295293_dynamic_regression" + +MARKERS = { + "Hepatocyte": ["Alb", "Apoa1", "Apoa2", "Ttr", "Cyp2e1", "Cps1", "Ass1"], + "HSC_Mesenchymal": ["Col1a1", "Col1a2", "Col3a1", "Dcn", "Col6a1", "Pdgfra", "Des", "Rgs5"], + "Endothelial": ["Pecam1", "Kdr", "Klf2", "Emcn", "Vwf", "Esam", "Klf4"], + "Myeloid": ["Lyz2", "Adgre1", "Csf1r", "Tyrobp", "C1qa", "C1qb", "Trem2"], + "T_NK": ["Cd3d", "Cd3e", "Trbc1", "Nkg7", "Klrk1", "Ccl5"], + "B_cell": ["Cd79a", "Ms4a1", "Cd37", "Cd74", "H2-Aa", "Cd19"], + "Cholangiocyte": ["Krt19", "Krt8", "Krt18", "Krt7", "Epcam", "Krt23"], +} + +# Frozen after review of canonical top markers from the first unsupervised run. +MANUAL_CLUSTER_LABELS = { + "0": "Endothelial", "1": "Endothelial", "2": "HSC_Mesenchymal", + "3": "Myeloid", "4": "Hepatocyte", "5": "Myeloid", + "6": "Cholangiocyte", "7": "Hepatocyte", "8": "B_cell", + "9": "Hepatocyte", "10": "T_NK", "11": "Myeloid", + "12": "Hepatocyte", "13": "Hepatocyte", "14": "Hepatocyte", + "15": "Hepatocyte", "16": "Hepatocyte", "17": "Hepatocyte", + "18": "Endothelial", "19": "Myeloid", "20": "Hepatocyte", + "21": "HSC_Mesenchymal", "22": "Hepatocyte", "23": "Cholangiocyte", + "24": "Endothelial", "25": "Hepatocyte", "26": "HSC_Mesenchymal", + "27": "Myeloid", "28": "Endothelial", "29": "Myeloid", + "30": "HSC_Mesenchymal", "31": "Endothelial", "32": "Myeloid", +} + + +def condition_from_name(name: str) -> str: + lowered = name.lower() + if "regression" in lowered: + return "regression" + if "firosis" in lowered or "fibrosis" in lowered: + return "fibrosis" + if "control" in lowered: + return "control" + raise ValueError(f"Cannot infer condition from {name}") + + +def extract_archive() -> None: + sentinel = WORK / ".extracted" + if sentinel.exists(): + return + with tarfile.open(ARCHIVE) as archive: + archive.extractall(WORK) + sentinel.touch() + + +def read_sample(matrix_path: Path) -> ad.AnnData: + prefix = matrix_path.name.removesuffix("_matrix.mtx.gz") + feature_path = matrix_path.with_name(prefix + "_features.tsv.gz") + barcode_path = matrix_path.with_name(prefix + "_barcodes.tsv.gz") + with gzip.open(matrix_path, "rb") as handle: + matrix = mmread(handle).tocsr().T + features = pd.read_csv(feature_path, sep="\t", header=None) + barcodes = pd.read_csv(barcode_path, sep="\t", header=None)[0].astype(str) + genes = pd.Index((features[1] if features.shape[1] > 1 else features[0]).astype(str), name=None) + genes.name = None + sample = re.match(r"(GSM\d+)", matrix_path.name).group(1) + result = ad.AnnData(matrix) + result.var_names = genes + result.var_names_make_unique() + result.obs_names = pd.Index((sample + "_" + barcodes).to_numpy(), name=None) + result.obs["sample"] = sample + result.obs["condition"] = condition_from_name(matrix_path.name) + result.obs["source_file"] = matrix_path.name + return result + + +def annotate_clusters(adata: ad.AnnData) -> pd.DataFrame: + available = set(adata.var_names) + score_columns = [] + for cell_type, markers in MARKERS.items(): + genes = [gene for gene in markers if gene in available] + if len(genes) < 2: + continue + column = f"score_{cell_type}" + sc.tl.score_genes(adata, genes, score_name=column, use_raw=False) + score_columns.append(column) + cluster_scores = adata.obs.groupby("leiden", observed=True)[score_columns].mean() + score_label = cluster_scores.idxmax(axis=1).str.removeprefix("score_") + cluster_label = pd.Series( + [MANUAL_CLUSTER_LABELS.get(str(cluster), score_label.loc[cluster]) for cluster in cluster_scores.index], + index=cluster_scores.index, + name="cell_type", + ) + adata.obs["cell_type"] = adata.obs.leiden.map(cluster_label).astype(str) + output = cluster_scores.copy() + output["cell_type"] = cluster_label + output["n_cells"] = adata.obs.leiden.value_counts().reindex(output.index) + return output.reset_index() + + +def pseudobulk(adata: ad.AnnData) -> tuple[pd.DataFrame, pd.DataFrame]: + rows, metadata = [], [] + for (sample, cell_type), index in adata.obs.groupby(["sample", "cell_type"], observed=True).indices.items(): + if len(index) < 30: + continue + counts = np.asarray(adata.layers["counts"][index].sum(axis=0)).ravel() + label = f"{sample}__{cell_type}" + rows.append(pd.Series(counts, index=adata.var_names, name=label)) + condition = adata.obs.iloc[index[0]].condition + metadata.append({"pseudobulk": label, "sample": sample, "cell_type": cell_type, + "condition": condition, "n_cells": len(index)}) + matrix = pd.DataFrame(rows).T + return matrix, pd.DataFrame(metadata) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--archive", type=Path, default=ARCHIVE) + parser.add_argument("--work-dir", type=Path, default=WORK) + parser.add_argument("--output-dir", type=Path, default=OUT) + return parser.parse_args() + + +def main() -> None: + global ARCHIVE, WORK, OUT + args = parse_args() + ARCHIVE, WORK, OUT = args.archive, args.work_dir, args.output_dir + WORK.mkdir(parents=True, exist_ok=True) + OUT.mkdir(parents=True, exist_ok=True) + sc.settings.seed = 20260711 + extract_archive() + matrices = sorted(WORK.glob("GSM*_matrix.mtx.gz")) + datasets = [read_sample(path) for path in matrices] + adata = ad.concat(datasets, join="inner", merge="same", index_unique=None) + adata.var_names_make_unique() + sc.pp.calculate_qc_metrics(adata, inplace=True, percent_top=None) + upper_counts = float(np.quantile(adata.obs.total_counts, 0.995)) + upper_genes = float(np.quantile(adata.obs.n_genes_by_counts, 0.995)) + adata = adata[(adata.obs.total_counts >= 150) & (adata.obs.n_genes_by_counts >= 80) + & (adata.obs.total_counts <= upper_counts) & (adata.obs.n_genes_by_counts <= upper_genes)].copy() + adata.layers["counts"] = adata.X.copy() + sc.pp.normalize_total(adata, target_sum=1e4) + sc.pp.log1p(adata) + adata.layers["lognorm"] = adata.X.copy() + sc.pp.highly_variable_genes(adata, n_top_genes=min(2500, adata.n_vars), flavor="seurat", subset=False) + sc.pp.scale(adata, max_value=10) + sc.tl.pca(adata, n_comps=40, use_highly_variable=True) + sc.pp.neighbors(adata, n_neighbors=20, n_pcs=30) + sc.tl.leiden(adata, resolution=0.8, key_added="leiden") + sc.tl.umap(adata, min_dist=0.35) + adata.X = adata.layers["lognorm"].copy() + cluster_annotation = annotate_clusters(adata) + cluster_annotation.to_csv(OUT / "cluster_annotation.tsv", sep="\t", index=False) + + sc.tl.rank_genes_groups(adata, "leiden", method="wilcoxon", pts=True) + markers = sc.get.rank_genes_groups_df(adata, group=None) + markers.groupby("group", observed=True).head(30).to_csv(OUT / "cluster_top_markers.tsv", sep="\t", index=False) + + coordinates = adata.obs[["sample", "condition", "leiden", "cell_type", "total_counts", "n_genes_by_counts"]].copy() + coordinates[["UMAP1", "UMAP2"]] = adata.obsm["X_umap"] + coordinates.to_csv(OUT / "cell_metadata_umap.tsv.gz", sep="\t", compression="gzip") + composition = adata.obs.groupby(["sample", "condition", "cell_type"], observed=True).size().rename("n_cells").reset_index() + composition.to_csv(OUT / "sample_celltype_counts.tsv", sep="\t", index=False) + + matrix, metadata = pseudobulk(adata) + matrix.to_csv(WORK / "pseudobulk_counts.tsv.gz", sep="\t", compression="gzip") + metadata.to_csv(WORK / "pseudobulk_metadata.tsv", sep="\t", index=False) + summary = { + "n_cells_after_qc": int(adata.n_obs), + "n_genes": int(adata.n_vars), + "n_samples": int(adata.obs["sample"].nunique()), + "condition_cells": adata.obs.condition.value_counts().to_dict(), + "cell_type_cells": adata.obs.cell_type.value_counts().to_dict(), + "n_pseudobulks": int(metadata.shape[0]), + } + (OUT / "preparation_summary.json").write_text(pd.Series(summary).to_json(indent=2)) + print(summary) + + +if __name__ == "__main__": + main() diff --git a/code/mouse/GSE305331_stream_state_trajectories.py b/code/mouse/GSE305331_stream_state_trajectories.py new file mode 100644 index 0000000..ad3dd50 --- /dev/null +++ b/code/mouse/GSE305331_stream_state_trajectories.py @@ -0,0 +1,173 @@ +#!/usr/bin/env python3 +"""Sequential pooled-library state trajectories from GSE305331 snRNA-seq.""" + +from __future__ import annotations + +import argparse +import gzip +import json +import tarfile +from pathlib import Path + +import anndata as ad +import numpy as np +import pandas as pd +import scanpy as sc +from scipy.io import mmread + + +REPO_ROOT = Path(__file__).resolve().parents[2] +ARCHIVE = REPO_ROOT / "data/raw_external/GSE305331/GSE305331_RAW.tar" +OUT = REPO_ROOT / "results/GSE305331_state_trajectories" + +SAMPLES = { + "GSM9168817": ("CCl4", "peak", 0), "GSM9168818": ("CCl4", "2wk", 2), + "GSM9168819": ("CCl4", "6wk", 6), "GSM9168820": ("FAT_MASH", "peak", 0), + "GSM9168821": ("FAT_MASH", "2wk", 2), "GSM9168822": ("FAT_MASH", "6wk", 6), + "GSM9168823": ("Untreated", "baseline", -1), +} +MARKERS = { + "Hepatocyte": ["Alb", "Apoa1", "Apoa2", "Ttr", "Cyp2e1", "Cps1", "Ass1"], + "HSC_Mesenchymal": ["Col1a1", "Col1a2", "Col3a1", "Dcn", "Cxcl12", "Hand2", "Pdgfra", "Des"], + "Endothelial": ["Aqp1", "Egfl7", "Dnase1l3", "Ptprb", "Clec4g", "Kdr", "Esam", "Stab2"], + "Myeloid": ["Lyz2", "Adgre1", "Csf1r", "Tyrobp", "C1qa", "C1qb", "Trem2"], + "T_NK": ["Cd3d", "Cd3e", "Trbc1", "Nkg7", "Klrk1", "Ccl5"], + "B_cell": ["Cd79a", "Ms4a1", "Cd37", "Cd74", "H2-Aa", "Cd19"], + "Cholangiocyte": ["Krt19", "Krt8", "Krt18", "Krt7", "Epcam", "Spp1"], +} +MODULES = { + "HSC_pathogenic_retention": ["Itgb5", "Gas7", "Spon1", "Pdgfra", "Lama2", "Epha3", "Dpysl3", "Svep1", "Fbln5", "Srpx2", "Nedd9"], + "HSC_SFRP_brake": ["Sfrp1", "Sfrp2", "Dkk3", "Timp3"], + "Endo4_WNT_resolver": ["Wnt9b", "Vwf", "Ace", "Wnt7b", "Kdr", "Emcn", "Esm1"], + "LAM_resolver": ["Trem2", "Gpnmb", "Spp1", "Cd9", "Lpl", "Mmp14", "Ctsb", "Ctsd"], +} +EXPECTED_TYPE = { + "HSC_pathogenic_retention": "HSC_Mesenchymal", "HSC_SFRP_brake": "HSC_Mesenchymal", + "Endo4_WNT_resolver": "Endothelial", "LAM_resolver": "Myeloid", +} + + +def member_name(archive: tarfile.TarFile, sample: str, suffix: str) -> str: + matches = [name for name in archive.getnames() if name.startswith(sample) and name.endswith(suffix)] + if len(matches) != 1: + raise ValueError(f"Expected one {sample} *{suffix}, found {matches}") + return matches[0] + + +def read_sample(archive: tarfile.TarFile, sample: str) -> ad.AnnData: + matrix_member = archive.extractfile(member_name(archive, sample, "_matrix.mtx.gz")) + feature_member = archive.extractfile(member_name(archive, sample, "_features.tsv.gz")) + barcode_member = archive.extractfile(member_name(archive, sample, "_barcodes.tsv.gz")) + if matrix_member is None or feature_member is None or barcode_member is None: + raise OSError(f"Cannot extract {sample}") + with gzip.GzipFile(fileobj=matrix_member) as handle: + matrix = mmread(handle).tocsr().T + with gzip.GzipFile(fileobj=feature_member) as handle: + features = pd.read_csv(handle, sep="\t", header=None) + with gzip.GzipFile(fileobj=barcode_member) as handle: + barcodes = pd.read_csv(handle, sep="\t", header=None)[0].astype(str) + genes = pd.Index(features[1].astype(str).to_numpy(), name=None) + result = ad.AnnData(matrix) + result.var_names = genes + result.var_names_make_unique() + result.obs_names = pd.Index((sample + "_" + barcodes).to_numpy(), name=None) + result.obs["sample"] = sample + return result + + +def process_sample(archive: tarfile.TarFile, sample: str) -> tuple[pd.DataFrame, pd.DataFrame, pd.DataFrame, pd.DataFrame]: + data = read_sample(archive, sample) + input_cells, input_genes, input_nnz = data.n_obs, data.n_vars, data.X.nnz + sc.pp.calculate_qc_metrics(data, inplace=True, percent_top=None) + upper_counts = np.quantile(data.obs.total_counts, 0.995) + upper_genes = np.quantile(data.obs.n_genes_by_counts, 0.995) + data = data[(data.obs.total_counts >= 200) & (data.obs.n_genes_by_counts >= 100) + & (data.obs.total_counts <= upper_counts) & (data.obs.n_genes_by_counts <= upper_genes)].copy() + sc.pp.normalize_total(data, target_sum=1e4) + sc.pp.log1p(data) + sc.pp.highly_variable_genes(data, n_top_genes=min(2500, data.n_vars), flavor="seurat") + representation = data[:, data.var.highly_variable].copy() + sc.pp.scale(representation, max_value=10) + sc.tl.pca(representation, n_comps=35) + sc.pp.neighbors(representation, n_neighbors=20, n_pcs=30) + sc.tl.leiden(representation, resolution=0.7, key_added="leiden", random_state=20260711) + data.obs["leiden"] = representation.obs["leiden"].astype(str).to_numpy() + del representation + + score_columns = [] + for cell_type, markers in MARKERS.items(): + genes = [gene for gene in markers if gene in data.var_names] + column = f"score_{cell_type}" + sc.tl.score_genes(data, genes, score_name=column) + score_columns.append(column) + cluster_scores = data.obs.groupby("leiden", observed=True)[score_columns].mean() + standardized = (cluster_scores - cluster_scores.mean()) / cluster_scores.std(ddof=0).replace(0, np.nan) + labels = standardized.idxmax(axis=1).str.removeprefix("score_") + labels[standardized.max(axis=1) < 1.0] = "Unresolved" + data.obs["cell_type"] = data.obs.leiden.map(labels).astype(str) + annotation = cluster_scores.copy() + annotation[[f"z_{column}" for column in score_columns]] = standardized + annotation["cell_type"] = labels + annotation["n_cells"] = data.obs.leiden.value_counts().reindex(annotation.index) + annotation["sample"] = sample + annotation = annotation.reset_index() + + etiology, timepoint, week = SAMPLES[sample] + composition = data.obs.cell_type.value_counts().rename_axis("cell_type").reset_index(name="n_cells") + composition["sample"] = sample + composition["etiology"] = etiology + composition["timepoint"] = timepoint + composition["week"] = week + + trajectory_rows = [] + for module, markers in MODULES.items(): + genes = [gene for gene in markers if gene in data.var_names] + sc.tl.score_genes(data, genes, score_name=module) + cell_type = EXPECTED_TYPE[module] + values = data.obs.loc[data.obs.cell_type == cell_type, module] + trajectory_rows.append({ + "sample": sample, "etiology": etiology, "timepoint": timepoint, "week": week, + "cell_type": cell_type, "module": module, "mean": values.mean(), + "median": values.median(), "count": len(values), "n_genes": len(genes), + }) + trajectory = pd.DataFrame(trajectory_rows) + summary = pd.DataFrame([{ + "sample": sample, "etiology": etiology, "timepoint": timepoint, "week": week, + "input_cells": input_cells, "cells_after_qc": data.n_obs, "genes": input_genes, + "input_nnz": input_nnz, "n_clusters": data.obs.leiden.nunique(), + }]) + return annotation, composition, trajectory, summary + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--archive", type=Path, default=ARCHIVE) + parser.add_argument("--output-dir", type=Path, default=OUT) + return parser.parse_args() + + +def main() -> None: + global ARCHIVE, OUT + args = parse_args() + ARCHIVE, OUT = args.archive, args.output_dir + OUT.mkdir(parents=True, exist_ok=True) + annotations, compositions, trajectories, summaries = [], [], [], [] + with tarfile.open(ARCHIVE) as archive: + for sample in SAMPLES: + annotation, composition, trajectory, summary = process_sample(archive, sample) + annotations.append(annotation); compositions.append(composition) + trajectories.append(trajectory); summaries.append(summary) + print(summary.to_string(index=False), flush=True) + pd.concat(annotations, ignore_index=True).to_csv(OUT / "cluster_annotation.tsv", sep="\t", index=False) + pd.concat(compositions, ignore_index=True).to_csv(OUT / "sample_celltype_counts.tsv", sep="\t", index=False) + pd.concat(trajectories, ignore_index=True).to_csv(OUT / "state_module_trajectories.tsv", sep="\t", index=False) + summary_table = pd.concat(summaries, ignore_index=True) + summary_table.to_csv(OUT / "sample_processing_summary.tsv", sep="\t", index=False) + (OUT / "inference_limit.json").write_text(json.dumps({ + "limit": "one pooled library per condition; descriptive trajectory only; cells are not biological replicates", + "annotation": "independent per-library clustering with broad marker z-score confidence gate", + }, indent=2)) + + +if __name__ == "__main__": + main() diff --git a/code/mouse/mouse_resolver_lock_trajectory.py b/code/mouse/mouse_resolver_lock_trajectory.py new file mode 100644 index 0000000..6461abc --- /dev/null +++ b/code/mouse/mouse_resolver_lock_trajectory.py @@ -0,0 +1,176 @@ +#!/usr/bin/env python3 +"""Project replicated and cross-etiology mouse withdrawal data into resolver-lock space.""" + +from __future__ import annotations + +import argparse +import itertools +import json +from pathlib import Path + +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +import seaborn as sns + + +REPO_ROOT=Path(__file__).resolve().parents[2] +COUNTS=REPO_ROOT/"data/mouse_pseudobulk_derived/pseudobulk_counts.tsv.gz" +META=REPO_ROOT/"data/mouse_pseudobulk_derived/pseudobulk_metadata.tsv" +POOLED=REPO_ROOT/"data/mouse_pseudobulk_derived/state_module_trajectories.tsv" +OUTPUT=REPO_ROOT/"results/S13_mouse_resolver_retention_trajectory" +COLORS={"control":"#2A9D8F","fibrosis":"#C43D55","regression":"#E5A93D"} + +MODULES={ + "HSC_retention":("HSC_Mesenchymal",["Itgb5","Gas7","Spon1","Svep1","Pdgfra","Lama2","Epha3","Dpysl3","Ltbp2","Efemp1","Serpine1"]), + "feedback_core":("HSC_Mesenchymal",["Serpine1","Spon1","Gas7","Ltbp2"]), + "TGF_latch":("HSC_Mesenchymal",["Tgfb1","Tgfbr1","Tgfbr2","Smad3","Smad7","Ctgf","Ccn2","Thbs1"]), + "antiproteolytic_brake":("HSC_Mesenchymal",["Serpine1","Timp1","Timp2","Thbs1"]), + "protease_potential":("Myeloid",["Plau","Plat","Mmp2","Mmp9","Mmp14"]), + "Endo_resolver":("Endothelial",["Wnt9b","Wnt7b","Vwf","Ace","Kdr","Esam","Emcn","Plvap","Klf2","Nr2f2"]), + "LAM_resolver":("Myeloid",["Trem2","Gpnmb","Lpl","Mmp14","Ctsb","Ctsd","Axl","Mertk"]), +} + + +def zscore(values: np.ndarray) -> np.ndarray: + return (values-values.mean())/max(values.std(ddof=1),1e-8) + + +def build_scores() -> tuple[pd.DataFrame,pd.DataFrame]: + counts=pd.read_csv(COUNTS,sep="\t",index_col=0) + meta=pd.read_csv(META,sep="\t") + audit=[]; score={} + for module,(cell_type,genes) in MODULES.items(): + local=meta.loc[meta.cell_type.eq(cell_type)].sort_values("sample") + columns=local.pseudobulk.tolist() + matrix=counts[columns] + library=matrix.sum(axis=0).to_numpy(float) + logcpm=np.log2((matrix.to_numpy(float)+.5)/(library[None,:]+1)*1e6) + expression=pd.DataFrame(logcpm,index=matrix.index,columns=local["sample"]) + present=list(dict.fromkeys(gene for gene in genes if gene in expression.index)) + gene_z=np.vstack([zscore(expression.loc[gene].to_numpy(float)) for gene in present]) + score[module]=gene_z.mean(axis=0) + audit.append({"module":module,"cell_type":cell_type,"requested":len(set(genes)),"present":len(present),"genes":";".join(present)}) + samples=meta[["sample","condition"]].drop_duplicates().sort_values("sample").reset_index(drop=True) + for module,values in score.items(): samples[module]=values + samples["clearance_inefficiency"]=zscore(samples.antiproteolytic_brake.to_numpy())-zscore(samples.protease_potential.to_numpy()) + lock_features=["HSC_retention","feedback_core","TGF_latch","clearance_inefficiency"] + resolver_features=["Endo_resolver","LAM_resolver"] + samples["lock_axis"]=np.mean([zscore(samples[name].to_numpy()) for name in lock_features],axis=0) + samples["resolver_axis"]=np.mean([zscore(samples[name].to_numpy()) for name in resolver_features],axis=0) + samples["control_imbalance"]=(samples.lock_axis-samples.resolver_axis)/np.sqrt(2) + return samples,pd.DataFrame(audit) + + +def exact_group_test(samples:pd.DataFrame,outcome:str) -> pd.DataFrame: + values=samples[outcome].to_numpy(float) + observed={} + means=samples.groupby("condition")[outcome].mean() + observed["progression"]=means.fibrosis-means.control + observed["withdrawal"]=means.regression-means.fibrosis + observed["residual"]=means.regression-means.control + null={name:[] for name in observed} + indices=set(range(9)) + for control in itertools.combinations(range(9),3): + remaining=indices-set(control) + for fibrosis in itertools.combinations(sorted(remaining),3): + regression=sorted(remaining-set(fibrosis)) + m0=values[list(control)].mean(); m1=values[list(fibrosis)].mean(); m2=values[regression].mean() + null["progression"].append(m1-m0); null["withdrawal"].append(m2-m1); null["residual"].append(m2-m0) + rows=[] + for contrast,effect in observed.items(): + distribution=np.asarray(null[contrast]) + rows.append({"outcome":outcome,"contrast":contrast,"effect":float(effect),"exact_two_sided_p":float((1+np.sum(np.abs(distribution)>=abs(effect)))/(len(distribution)+1)),"exact_directional_p":float((1+np.sum(distribution>=effect))/(len(distribution)+1)) if effect>=0 else float((1+np.sum(distribution<=effect))/(len(distribution)+1)),"n_assignments":len(distribution)}) + return pd.DataFrame(rows) + + +def geometry(samples:pd.DataFrame) -> dict: + centroids=samples.groupby("condition")[["resolver_axis","lock_axis"]].mean() + control=centroids.loc["control"].to_numpy(); fibrosis=centroids.loc["fibrosis"].to_numpy(); regression=centroids.loc["regression"].to_numpy() + progression=fibrosis-control; recovery=regression-fibrosis + cosine=float(np.dot(-progression,recovery)/(np.linalg.norm(progression)*np.linalg.norm(recovery))) + return { + "progression_vector":progression.tolist(),"withdrawal_vector":recovery.tolist(), + "return_cosine":cosine,"return_angle_degrees":float(np.degrees(np.arccos(np.clip(cosine,-1,1)))), + "residual_distance_ratio":float(np.linalg.norm(regression-control)/np.linalg.norm(fibrosis-control)), + "control_centroid":control.tolist(),"fibrosis_centroid":fibrosis.tolist(),"regression_centroid":regression.tolist(), + } + + +def pooled_trajectories() -> pd.DataFrame: + d=pd.read_csv(POOLED,sep="\t") + p=d.pivot_table(index=["sample","etiology","timepoint","week"],columns="module",values="mean").reset_index() + p["resolver_proxy"]=p[["Endo4_WNT_resolver","LAM_resolver"]].mean(axis=1) + p["lock_proxy"]=p["HSC_pathogenic_retention"] + for column in ["resolver_proxy","lock_proxy"]: + p[column]=zscore(p[column].to_numpy(float)) + return p + + +def plot(samples:pd.DataFrame,pooled:pd.DataFrame,geom:dict) -> None: + sns.set_theme(style="ticks",context="paper",font_scale=1.0) + fig=plt.figure(figsize=(14.5,10.5)) + grid=fig.add_gridspec(2,2,left=.07,right=.98,bottom=.07,top=.91,wspace=.30,hspace=.34) + ax=fig.add_subplot(grid[0,0]) + for condition,local in samples.groupby("condition",observed=True): ax.scatter(local.resolver_axis,local.lock_axis,s=58,color=COLORS[condition],label=condition,edgecolor="white",linewidth=.7) + cent=samples.groupby("condition")[["resolver_axis","lock_axis"]].mean() + for start,end in [("control","fibrosis"),("fibrosis","regression")]: ax.annotate("",xy=cent.loc[end],xytext=cent.loc[start],arrowprops=dict(arrowstyle="-|>",lw=2.3,color="#424A4E")) + ax.axline((0,0),slope=1,color="#7E898E",ls="--",lw=1) + ax.set(xlabel="Resolver capacity",ylabel="HSC lock load") + ax.set_title("A Replicated withdrawal follows a non-reciprocal return path",loc="left",fontweight="bold"); ax.legend(frameon=False) + + ax=fig.add_subplot(grid[0,1]) + long=samples.melt(id_vars=["sample","condition"],value_vars=["resolver_axis","lock_axis","control_imbalance"],var_name="axis",value_name="score") + sns.boxplot(data=long,x="condition",y="score",hue="axis",palette={"resolver_axis":"#3182A6","lock_axis":"#B83D4B","control_imbalance":"#765A89"},fliersize=0,ax=ax) + sns.stripplot(data=long,x="condition",y="score",hue="axis",dodge=True,palette={"resolver_axis":"#3182A6","lock_axis":"#B83D4B","control_imbalance":"#765A89"},size=4,ax=ax,legend=False) + ax.axhline(0,color="#777",lw=.8); ax.set(xlabel="",ylabel="Standardized control score") + ax.set_title("B Lock load remains displaced after injury withdrawal",loc="left",fontweight="bold"); ax.legend(frameon=False,ncol=3,fontsize=7) + + ax=fig.add_subplot(grid[1,0]); ax.set_axis_off(); ax.set_xlim(0,1); ax.set_ylim(0,1) + ax.text(.03,.90,"CONTROL",color=COLORS['control'],fontweight="bold",fontsize=12) + ax.annotate("",xy=(.48,.72),xytext=(.18,.82),arrowprops=dict(arrowstyle="-|>",lw=6,color=COLORS['fibrosis'])) + ax.text(.50,.70,"FIBROSIS",color=COLORS['fibrosis'],fontweight="bold",fontsize=12) + ax.annotate("",xy=(.73,.45),xytext=(.53,.66),arrowprops=dict(arrowstyle="-|>",lw=6,color=COLORS['regression'])) + ax.text(.75,.42,"REGRESSION",color="#A87513",fontweight="bold",fontsize=12) + ax.plot([.75,.12],[.35,.75],ls="--",color="#879198",lw=1.2) + ax.text(.53,.20,f"Return angle {geom['return_angle_degrees']:.1f}°\nResidual distance {geom['residual_distance_ratio']:.2f}× peak displacement",ha="center",fontsize=11,bbox=dict(boxstyle="round,pad=.45",fc="white",ec="#919BA0")) + ax.set_title("C Incomplete withdrawal displacement",loc="left",fontweight="bold") + + ax=fig.add_subplot(grid[1,1]) + baseline=pooled.loc[pooled.etiology.eq("Untreated")].iloc[0] + ax.scatter(baseline.resolver_proxy,baseline.lock_proxy,s=90,color="#626B70",marker="s",label="untreated") + for etiology,color in [("CCl4","#3C78A8"),("FAT_MASH","#B64554")]: + local=pooled.loc[pooled.etiology.eq(etiology)].sort_values("week") + ax.plot(local.resolver_proxy,local.lock_proxy,marker="o",lw=2.3,color=color,label=etiology) + for _,row in local.iterrows(): ax.text(row.resolver_proxy+.03,row.lock_proxy+.03,row.timepoint,fontsize=7,color=color) + ax.axline((0,0),slope=1,color="#7E898E",ls="--",lw=1) + ax.set(xlabel="Resolver proxy",ylabel="HSC-retention proxy") + ax.set_title("D Cross-etiology trajectories converge on late resolver loss",loc="left",fontweight="bold"); ax.legend(frameon=False) + for axis in fig.axes: + if axis.axison: axis.spines[["top","right"]].set_visible(False) + fig.suptitle("Mouse withdrawal trajectories connect temporal non-reciprocity to the human resolver–lock landscape",fontsize=16,fontweight="bold") + fig.savefig(OUTPUT/"Mouse_resolver_lock_trajectory.png",dpi=320,facecolor="white"); fig.savefig(OUTPUT/"Mouse_resolver_lock_trajectory.pdf",facecolor="white"); plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser=argparse.ArgumentParser(description=__doc__) + parser.add_argument("--counts",type=Path,default=COUNTS) + parser.add_argument("--metadata",type=Path,default=META) + parser.add_argument("--pooled-trajectories",type=Path,default=POOLED) + parser.add_argument("--output-dir",type=Path,default=OUTPUT) + return parser.parse_args() + + +def main(): + global COUNTS,META,POOLED,OUTPUT + args=parse_args() + COUNTS,META,POOLED,OUTPUT=args.counts,args.metadata,args.pooled_trajectories,args.output_dir + OUTPUT.mkdir(parents=True,exist_ok=True) + samples,audit=build_scores(); pooled=pooled_trajectories(); geom=geometry(samples) + tests=pd.concat([exact_group_test(samples,outcome) for outcome in ["resolver_axis","lock_axis","control_imbalance"]],ignore_index=True) + plot(samples,pooled,geom) + samples.to_csv(OUTPUT/"GSE295293_mouse_phase_scores.tsv",sep="\t",index=False); audit.to_csv(OUTPUT/"mouse_module_mapping.tsv",sep="\t",index=False); tests.to_csv(OUTPUT/"GSE295293_exact_phase_tests.tsv",sep="\t",index=False); pooled.to_csv(OUTPUT/"GSE305331_cross_etiology_phase_trajectories.tsv",sep="\t",index=False) + summary={"n_replicated_mice":len(samples),"geometry":geom,"tests":tests.to_dict(orient="records"),"claim":"Withdrawal follows a non-reciprocal trajectory with residual displacement in resolver-lock space."} + (OUTPUT/"mouse_phase_trajectory_summary.json").write_text(json.dumps(summary,indent=2,ensure_ascii=False)+"\n"); print(json.dumps(summary,indent=2,ensure_ascii=False)) + +if __name__=="__main__": main() diff --git a/code/perturbation/LINCS_AP1_genetic_perturbation.py b/code/perturbation/LINCS_AP1_genetic_perturbation.py new file mode 100644 index 0000000..0f8dc9f --- /dev/null +++ b/code/perturbation/LINCS_AP1_genetic_perturbation.py @@ -0,0 +1,236 @@ +#!/usr/bin/env python3 +"""Test AP-1 factor direction with LINCS consensus shRNA, hairpins and overexpression.""" + +from __future__ import annotations + +import argparse +from pathlib import Path + +import h5py +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +import seaborn as sns + + +REPO_ROOT = Path(__file__).resolve().parents[2] +META = REPO_ROOT / "data/raw_external/LINCS/GSE92742" +GCTX = REPO_ROOT / "data/raw_external/LINCS/GSE92742_Level5_COMPZ.MODZ.gctx" +FRA = REPO_ROOT / "data/perturbation_inputs/fibrosis_reversibility_axis_v15.tsv" +OUT = REPO_ROOT / "results/S8_LINCS_AP1_genetic_perturbation" +FIG = OUT / "figures" +TARGETS = ["JUN", "FOS", "JUNB", "FOSL2"] + +RETENTION = [ + "ITGB5", "GAS7", "SPON1", "SVEP1", "PDGFRA", "LAMA2", "EPHA3", + "DPYSL3", "LTBP2", "EFEMP1", "SERPINE1", "COL1A1", "COL3A1", + "LOXL2", "ACTA2", "TIMP1", "THBS2", "FBLN5", +] +ENDO = ["WNT9B", "WNT7B", "VWF", "ACE", "KDR", "ESAM", "EMCN", "PLVAP", "KLF2", "NR2F2"] +MACRO = ["TREM2", "GPNMB", "LPL", "MMP14", "CTSB", "CTSD", "AXL", "MERTK"] + + +def decode(values: np.ndarray) -> list[str]: + return [x.decode() if isinstance(x, (bytes, np.bytes_)) else str(x) for x in values] + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--metadata-dir", type=Path, default=META) + parser.add_argument("--gctx", type=Path, default=GCTX) + parser.add_argument("--fra-axis", type=Path, default=FRA) + parser.add_argument("--output-dir", type=Path, default=OUT) + parser.add_argument("--figure-dir", type=Path, default=None) + return parser.parse_args() + + +def main() -> None: + global META, GCTX, FRA, OUT, FIG + args = parse_args() + META, GCTX, FRA, OUT = args.metadata_dir, args.gctx, args.fra_axis, args.output_dir + FIG = args.figure_dir or OUT / "figures" + OUT.mkdir(parents=True, exist_ok=True) + FIG.mkdir(parents=True, exist_ok=True) + sig = pd.read_csv(META / "GSE92742_sig_info.txt.gz", sep="\t", low_memory=False) + gene = pd.read_csv(META / "GSE92742_gene_info.txt.gz", sep="\t", dtype=str) + gene["symbol"] = gene["pr_gene_symbol"].str.upper() + symbol_to_id = gene.drop_duplicates("symbol").set_index("symbol")["pr_gene_id"].to_dict() + fra = pd.read_csv(FRA, sep="\t") + fra = fra.loc[fra["fra_axis_weight"] > 0, ["gene_symbol", "fra_axis_weight"]].drop_duplicates("gene_symbol") + fra["gene_symbol"] = fra["gene_symbol"].str.upper() + + target_mask = sig["pert_iname"].astype(str).str.upper().isin(TARGETS) + target_mask &= sig["pert_type"].isin(["trt_sh.cgs", "trt_sh", "trt_oe"]) + null_mask = sig["pert_type"].eq("trt_sh.cgs") + selected = sig[target_mask | null_mask].copy() + + with h5py.File(GCTX, "r") as handle: + matrix = handle["0/DATA/0/matrix"] + sig_ids = decode(handle["0/META/COL/id"][:]) + gene_ids = decode(handle["0/META/ROW/id"][:]) + sig_index = {value: i for i, value in enumerate(sig_ids)} + gene_index = {value: i for i, value in enumerate(gene_ids)} + selected = selected[selected["sig_id"].astype(str).isin(sig_index)].copy() + + mapped = { + "retention": [(g, symbol_to_id.get(g)) for g in RETENTION], + "endo": [(g, symbol_to_id.get(g)) for g in ENDO], + "macro": [(g, symbol_to_id.get(g)) for g in MACRO], + } + mapped = {name: [(g, gene_index[i]) for g, i in values if i in gene_index] for name, values in mapped.items()} + fra["gctx_index"] = fra["gene_symbol"].map(symbol_to_id).map(gene_index) + fra = fra.dropna(subset=["gctx_index"]).copy() + fra["gctx_index"] = fra["gctx_index"].astype(int) + all_cols = sorted(set(i for values in mapped.values() for _, i in values) | set(fra["gctx_index"])) + col_pos = {value: i for i, value in enumerate(all_cols)} + positions = {name: [col_pos[i] for _, i in values] for name, values in mapped.items()} + fra_pos = [col_pos[i] for i in fra["gctx_index"]] + fra_weights = fra["fra_axis_weight"].to_numpy(float) + fra_weights = fra_weights / fra_weights.sum() + + pairs = sorted((sig_index[sid], sid) for sid in selected["sig_id"].astype(str)) + output = [] + for start in range(0, len(pairs), 1000): + batch = pairs[start:start + 1000] + values = matrix[[i for i, _ in batch], :][:, all_cols].astype(np.float64) + retention = -np.nanmean(values[:, positions["retention"]], axis=1) + endo = np.nanmean(values[:, positions["endo"]], axis=1) + macro = np.nanmean(values[:, positions["macro"]], axis=1) + fra_rescue = -(values[:, fra_pos] @ fra_weights) + floor = np.minimum(endo, macro) + dual = retention + 0.5 * endo + 0.5 * macro - 1.5 * np.maximum(0, -floor) + for j, (_, sid) in enumerate(batch): + output.append({ + "sig_id": sid, + "retention_suppression": retention[j], + "endo_resolver_support": endo[j], + "macro_resolver_support": macro[j], + "fra_rescue": fra_rescue[j], + "dual_control_score": dual[j], + }) + + scores = pd.DataFrame(output).merge(selected, on="sig_id", how="left") + scores.to_csv(OUT / "LINCS_AP1_genetic_signature_scores.tsv.gz", sep="\t", index=False, compression="gzip") + + cgs = scores[scores["pert_type"].eq("trt_sh.cgs")].copy() + target_cgs = cgs[cgs["pert_iname"].astype(str).str.upper().isin(TARGETS)].copy() + null_rows = [] + for row in target_cgs.itertuples(index=False): + null = cgs[(cgs["cell_id"].eq(row.cell_id)) & (cgs["pert_time"].eq(row.pert_time))] + record = {"sig_id": row.sig_id, "target": str(row.pert_iname).upper(), "cell_id": row.cell_id, + "pert_time": row.pert_time, "n_same_context_cgs": len(null)} + for metric in ["retention_suppression", "fra_rescue", "dual_control_score"]: + value = getattr(row, metric) + record[metric] = value + record[f"{metric}_percentile"] = float((null[metric] <= value).mean()) + p_low = float((1 + (null[metric] <= value).sum()) / (len(null) + 1)) + p_high = float((1 + (null[metric] >= value).sum()) / (len(null) + 1)) + record[f"{metric}_empirical_p_low"] = p_low + record[f"{metric}_empirical_p_high"] = p_high + record[f"{metric}_empirical_p_two_sided"] = min(1.0, 2 * min(p_low, p_high)) + null_rows.append(record) + target_null = pd.DataFrame(null_rows) + target_null.to_csv(OUT / "AP1_consensus_shRNA_context_null.tsv", sep="\t", index=False) + + target_scores = scores[scores["pert_iname"].astype(str).str.upper().isin(TARGETS)].copy() + target_scores["target"] = target_scores["pert_iname"].astype(str).str.upper() + summary = target_scores.groupby(["target", "pert_type", "cell_id"], observed=True).agg( + n_signatures=("sig_id", "nunique"), n_pert_ids=("pert_id", "nunique"), + median_retention_suppression=("retention_suppression", "median"), + fraction_retention_positive=("retention_suppression", lambda x: float((x > 0).mean())), + median_fra_rescue=("fra_rescue", "median"), + fraction_fra_positive=("fra_rescue", lambda x: float((x > 0).mean())), + median_dual_control=("dual_control_score", "median"), + ).reset_index() + summary.to_csv(OUT / "AP1_genetic_perturbation_summary.tsv", sep="\t", index=False) + + target_cgs["target"] = target_cgs["pert_iname"].astype(str).str.upper() + pan = target_cgs.groupby("target", observed=True).agg( + n_contexts=("sig_id", "size"), + cell_lines=("cell_id", lambda x: ";".join(sorted(set(map(str, x))))), + median_retention_suppression=("retention_suppression", "median"), + fraction_retention_positive=("retention_suppression", lambda x: float((x > 0).mean())), + median_fra_rescue=("fra_rescue", "median"), + fraction_fra_positive=("fra_rescue", lambda x: float((x > 0).mean())), + median_dual_control=("dual_control_score", "median"), + fraction_dual_positive=("dual_control_score", lambda x: float((x > 0).mean())), + ).reset_index() + pan.to_csv(OUT / "AP1_consensus_shRNA_pan_context.tsv", sep="\t", index=False) + + wide = summary[summary["cell_id"].eq("HEPG2")].pivot(index="target", columns="pert_type", values="median_fra_rescue") + for column in ["trt_sh.cgs", "trt_sh", "trt_oe"]: + if column not in wide: + wide[column] = np.nan + wide["cgs_hairpin_same_sign"] = np.sign(wide["trt_sh.cgs"]) == np.sign(wide["trt_sh"]) + wide["cgs_oe_opposite_sign"] = np.sign(wide["trt_sh.cgs"]) == -np.sign(wide["trt_oe"]) + wide.reset_index().to_csv(OUT / "AP1_HEPG2_directional_concordance.tsv", sep="\t", index=False) + + arbitration = target_null[target_null["cell_id"].eq("HEPG2")].merge( + pan[["target", "n_contexts", "median_fra_rescue", "fraction_fra_positive", + "median_dual_control", "fraction_dual_positive"]], on="target", how="left" + ).merge(wide.reset_index(), on="target", how="left", suffixes=("", "_hepg2_median")) + arbitration.to_csv(OUT / "AP1_HEPG2_arbitration.tsv", sep="\t", index=False) + + sns.set_theme(style="ticks", context="paper") + fig, axes = plt.subplots(2, 2, figsize=(12.5, 9), constrained_layout=True) + hep = target_cgs[target_cgs["cell_id"].eq("HEPG2")].copy() + hep["target"] = hep["pert_iname"].astype(str).str.upper() + hep = hep.set_index("target").reindex(TARGETS).reset_index() + x = np.arange(len(hep)) + ax = axes[0, 0] + metrics = [("retention_suppression", "Retention", "#C7472E"), ("fra_rescue", "FRA", "#2A6F97"), + ("dual_control_score", "Dual control", "#6A994E")] + for j, (column, label, color) in enumerate(metrics): + ax.bar(x + (j - 1) * .24, hep[column], width=.22, color=color, label=label) + ax.axhline(0, color="#777777", lw=.8) + ax.set_xticks(x, hep["target"]) + ax.set_ylabel("LINCS Level 5 score") + ax.set_title("A HepG2 consensus shRNA direction", loc="left", fontweight="bold") + ax.legend(frameon=False) + + ax = axes[0, 1] + null_hep = target_null[target_null["cell_id"].eq("HEPG2")].set_index("target").reindex(TARGETS).reset_index() + ax.bar(x, null_hep["fra_rescue_percentile"], color="#2A6F97") + ax.axhline(.95, color="#C7472E", ls="--", lw=1) + ax.set_xticks(x, null_hep["target"]) + ax.set_ylim(0, 1) + ax.set_ylabel("Percentile among same-context CGS") + ax.set_title("B Empirical same-cell, same-time null", loc="left", fontweight="bold") + + ax = axes[1, 0] + pan_heatmap = target_cgs.pivot_table(index="pert_iname", columns="cell_id", values="fra_rescue", aggfunc="median") + pan_heatmap.index = pan_heatmap.index.astype(str).str.upper() + pan_heatmap = pan_heatmap.reindex(TARGETS) + sns.heatmap(pan_heatmap, cmap="vlag", center=0, linewidths=.3, cbar_kws={"label": "FRA rescue"}, ax=ax) + ax.set_xlabel(""); ax.set_ylabel("") + ax.set_title("C Consensus knockdown across cell contexts", loc="left", fontweight="bold") + + ax = axes[1, 1] + hep_summary = summary[summary["cell_id"].eq("HEPG2")].copy() + plot = hep_summary.pivot(index="target", columns="pert_type", values="median_fra_rescue").reindex(TARGETS) + for j, (column, label, color) in enumerate([ + ("trt_sh.cgs", "Consensus shRNA", "#2A6F97"), + ("trt_sh", "Individual shRNA", "#EDAE49"), + ("trt_oe", "Overexpression", "#C7472E"), + ]): + values = plot[column] if column in plot else np.full(len(plot), np.nan) + ax.bar(x + (j - 1) * .24, values, width=.22, label=label, color=color) + ax.axhline(0, color="#777777", lw=.8) + ax.set_xticks(x, plot.index) + ax.set_ylabel("Median FRA rescue") + ax.set_title("D Hairpin and overexpression polarity", loc="left", fontweight="bold") + ax.legend(frameon=False) + for ax in axes.ravel(): + ax.spines[["top", "right"]].set_visible(False) + fig.suptitle("Genetic LINCS signatures test AP-1 factor direction outside the network models", + fontsize=14, fontweight="bold") + fig.savefig(FIG / "Figure_v16_LINCS_AP1_genetic_perturbation.png", dpi=350, bbox_inches="tight") + fig.savefig(FIG / "Figure_v16_LINCS_AP1_genetic_perturbation.pdf", bbox_inches="tight") + plt.close(fig) + + print(target_null[target_null["cell_id"].eq("HEPG2")].to_string(index=False)) + print(wide.to_string()) + + +if __name__ == "__main__": + main() diff --git a/code/perturbation/celloracle_v16_ap1_runx2_test.py b/code/perturbation/celloracle_v16_ap1_runx2_test.py new file mode 100644 index 0000000..ec9fc18 --- /dev/null +++ b/code/perturbation/celloracle_v16_ap1_runx2_test.py @@ -0,0 +1,442 @@ +#!/usr/bin/env python3 +"""Orthogonally compare RUNX2, JUN and FOS in the cirrhotic HSC GRN.""" + +from __future__ import annotations + +import contextlib +import os +import traceback +from concurrent.futures import ProcessPoolExecutor, as_completed +from pathlib import Path + +import anndata as ad +import celloracle as co +import numpy as np +import pandas as pd +from scipy import sparse, stats + +from celloracle.trajectory.oracle_GRN import _do_simulation + + +REPO_ROOT = Path(__file__).resolve().parents[2] +ROOT = Path(os.environ.get("PN_ROOT", REPO_ROOT / "data/external_runtime")) +INPUT = ROOT / "01_scRNA/v15/perturbation_inputs" +V16 = Path(os.environ.get("V16_ROOT", REPO_ROOT / "work/v16_runtime")) +OUTPUT = V16 / "02_results/S7_hsc_control_perturbation/celloracle_ap1_runx2" +BASE_GRN = ( + ROOT + / "00_raw/models_v15/celloracle/" + / "human_promoter_base_GRN_hg19_gimmemotifsv5_fpr2.parquet" +) +SEED = 20260710 +STATE_SLUGS = ["hsc_myofibroblast"] +V16_TARGETS = ["RUNX2", "JUN", "FOS"] + + +def build_oracle(adata: ad.AnnData, disease: str, seed: int) -> co.Oracle: + np.random.seed(seed) + subset = adata[adata.obs["disease"].astype(str).eq(disease)].copy() + subset.obs["donor"] = subset.obs["donor"].astype(str).astype("category") + oracle = co.Oracle() + oracle.import_anndata_as_raw_count( + subset, + cluster_column_name="donor", + embedding_name="X_umap", + transform="natural_log", + ) + oracle.import_TF_data(TF_info_matrix_path=str(BASE_GRN)) + n_components = min(50, subset.n_obs - 1, subset.n_vars - 1) + oracle.perform_PCA(n_components=n_components) + k = max(10, min(50, int(subset.n_obs * 0.025))) + oracle.knn_imputation( + k=k, + n_pca_dims=min(40, n_components), + balanced=True, + b_sight=min(k * 8, subset.n_obs - 1), + b_maxl=min(k * 4, subset.n_obs - 1), + n_jobs=3, + ) + oracle.fit_GRN_for_simulation( + GRN_unit="whole", alpha=10, use_cluster_specific_TFdict=False, verbose_level=0 + ) + return oracle + + +def donor_means(oracle: co.Oracle) -> pd.DataFrame: + expression = oracle.adata.to_df(layer="imputed_count") + expression["__donor"] = oracle.adata.obs["donor"].astype(str).to_numpy() + return expression.groupby("__donor", observed=True).mean() + + +def choose_controls( + coefficient: pd.DataFrame, + expression: pd.DataFrame, + targets: list[str], + excluded: set[str], +) -> pd.DataFrame: + out_strength = coefficient.abs().sum(axis=1) + mean_expression = expression.mean(axis=0) + pool = [ + gene + for gene in coefficient.index + if gene not in excluded + and gene not in targets + and out_strength.get(gene, 0) > 0 + and mean_expression.get(gene, 0) > 0.02 + and not gene.startswith(("MT-", "RPS", "RPL")) + ] + selected: list[str] = [] + rows: list[dict[str, object]] = [] + for target in targets: + candidates = [gene for gene in pool if gene not in selected] + if not candidates: + raise RuntimeError(f"No matched-control pool remains for {target}") + target_degree = np.log1p(out_strength[target]) + target_expression = np.log1p(mean_expression[target]) + distances = { + gene: abs(np.log1p(out_strength[gene]) - target_degree) + + abs(np.log1p(mean_expression[gene]) - target_expression) + for gene in candidates + } + control = min(distances, key=distances.get) + selected.append(control) + rows.append( + { + "target": target, + "control": control, + "target_out_strength": out_strength[target], + "control_out_strength": out_strength[control], + "target_mean_expression": mean_expression[target], + "control_mean_expression": mean_expression[control], + "matching_distance": distances[control], + } + ) + return pd.DataFrame(rows) + + +def cosine(left: np.ndarray, right: np.ndarray) -> float: + denominator = np.linalg.norm(left) * np.linalg.norm(right) + if denominator == 0: + return np.nan + return float(np.dot(left, right) / denominator) + + +def simulate( + expression: pd.DataFrame, + coefficient: pd.DataFrame, + gene: str, +) -> pd.DataFrame: + simulation_input = expression.copy() + simulation_input.loc[:, gene] = 0.0 + simulated = _do_simulation( + coef_matrix=coefficient, + simulation_input=simulation_input, + gem=expression, + n_propagation=3, + ) + return simulated - expression + + +def summarize_delta( + delta: pd.DataFrame, + disease_vector: pd.Series, + fra_weights: pd.Series, + state_slug: str, + perturb_gene: str, + role: str, + matched_to: str | None, + network_type: str, +) -> pd.DataFrame: + fra_genes = fra_weights.index.intersection(delta.columns) + weights = fra_weights.loc[fra_genes] + weights = weights / weights.sum() + rows: list[dict[str, object]] = [] + for donor, values in delta.iterrows(): + fra_delta = values.loc[fra_genes] + disease = disease_vector.loc[fra_genes] + rows.append( + { + "state_slug": state_slug, + "donor": donor, + "perturb_gene": perturb_gene, + "role": role, + "matched_to": matched_to, + "network_type": network_type, + "fra_rescue_score": -float(np.average(fra_delta, weights=weights)), + "fra_down_fraction": float((fra_delta < 0).mean()), + "fra_disease_reversal_cosine": cosine( + fra_delta.to_numpy(), -disease.to_numpy() + ), + "global_disease_reversal_cosine": cosine( + values.to_numpy(), -disease_vector.loc[values.index].to_numpy() + ), + "rms_shift": float(np.sqrt(np.mean(values.to_numpy() ** 2))), + "target_delta": float(values.get(perturb_gene, np.nan)), + } + ) + return pd.DataFrame(rows) + + +def summarize_donors(donor_metrics: pd.DataFrame) -> pd.DataFrame: + keys = ["state_slug", "perturb_gene", "role", "matched_to", "network_type"] + metrics = [ + "fra_rescue_score", + "fra_down_fraction", + "fra_disease_reversal_cosine", + "global_disease_reversal_cosine", + "rms_shift", + "target_delta", + ] + rows: list[dict[str, object]] = [] + for key, frame in donor_metrics.groupby(keys, dropna=False, observed=True): + row = dict(zip(keys, key)) + row["n_donors"] = len(frame) + for metric in metrics: + values = frame[metric].dropna().to_numpy(float) + row[f"mean_{metric}"] = np.mean(values) if len(values) else np.nan + row[f"sd_{metric}"] = np.std(values, ddof=1) if len(values) > 1 else np.nan + rescue = frame["fra_rescue_score"].dropna().to_numpy(float) + row["n_donors_positive_fra_rescue"] = int((rescue > 0).sum()) + row["fra_rescue_ttest_p"] = ( + stats.ttest_1samp(rescue, popmean=0).pvalue if len(rescue) >= 3 else np.nan + ) + rows.append(row) + return pd.DataFrame(rows) + + +def bootstrap_mean(values: np.ndarray, seed: int) -> tuple[float, float]: + rng = np.random.default_rng(seed) + estimates = np.mean( + rng.choice(values, size=(5000, len(values)), replace=True), axis=1 + ) + return tuple(np.quantile(estimates, [0.025, 0.975])) + + +def run_state(state_slug: str, state_index: int) -> dict[str, str]: + state_output = OUTPUT / state_slug + state_output.mkdir(parents=True, exist_ok=True) + log_path = state_output / "run.log" + with log_path.open("w") as log, contextlib.redirect_stdout(log), contextlib.redirect_stderr(log): + try: + print(f"state={state_slug} seed={SEED + state_index}", flush=True) + adata = ad.read_h5ad(INPUT / state_slug / "celloracle_input.h5ad") + targets = V16_TARGETS + fra = pd.read_csv( + ROOT / "05_GRN/v15/fibrosis_reversibility_axis_v15.tsv", sep="\t" + ) + fra_weights = ( + fra.loc[fra["fra_axis_weight"] > 0, ["gene_symbol", "fra_axis_weight"]] + .drop_duplicates("gene_symbol") + .set_index("gene_symbol")["fra_axis_weight"] + ) + axes = pd.read_csv( + ROOT / "04_CCC_LR/v15/mechanism_axis_consensus.tsv", sep="\t" + ) + excluded = set(fra["gene_symbol"].dropna().astype(str)) + excluded.update(axes["ligand"].dropna().astype(str)) + excluded.update(axes["receptor"].dropna().astype(str)) + + healthy = build_oracle(adata, "healthy", SEED + state_index * 10 + 1) + cirrhotic = build_oracle(adata, "cirrhotic", SEED + state_index * 10 + 2) + healthy_expression = donor_means(healthy) + cirrhotic_expression = donor_means(cirrhotic) + disease_vector = cirrhotic_expression.mean() - healthy_expression.mean() + coefficient = cirrhotic.coef_matrix.copy() + healthy_coefficient = healthy.coef_matrix.copy() + + genes = coefficient.index.astype(str) + pd.Series(genes).to_csv(state_output / "coefficient_genes.tsv", index=False, header=False) + sparse.save_npz( + state_output / "cirrhotic_coefficient_matrix.npz", + sparse.csr_matrix(coefficient.to_numpy()), + compressed=True, + ) + sparse.save_npz( + state_output / "healthy_coefficient_matrix.npz", + sparse.csr_matrix(healthy_coefficient.loc[genes, genes].to_numpy()), + compressed=True, + ) + + active_targets = [ + gene + for gene in targets + if gene in coefficient.index and coefficient.loc[gene].abs().sum() > 0 + ] + unavailable = sorted(set(targets) - set(active_targets)) + pd.DataFrame( + { + "target": targets, + "status": [ + "active_cirrhotic_GRN" if gene in active_targets else "no_outgoing_cirrhotic_edge" + for gene in targets + ], + } + ).to_csv(state_output / "target_availability.tsv", sep="\t", index=False) + if not active_targets: + raise RuntimeError(f"No active CellOracle targets in {state_slug}: {unavailable}") + + controls = choose_controls( + coefficient, cirrhotic_expression, active_targets, excluded + ) + controls.to_csv( + state_output / "degree_expression_matched_controls.tsv", sep="\t", index=False + ) + cirrhotic.calculate_randomized_coef_table() + randomized = cirrhotic.coef_matrix_randomized.copy() + + donor_frames: list[pd.DataFrame] = [] + gene_frames: list[pd.DataFrame] = [] + perturbations = [ + (gene, "prespecified_candidate", None) for gene in active_targets + ] + [ + (row.control, "degree_expression_matched_null", row.target) + for row in controls.itertuples(index=False) + ] + for gene, role, matched_to in perturbations: + delta = simulate(cirrhotic_expression, coefficient, gene) + donor_frames.append( + summarize_delta( + delta, + disease_vector, + fra_weights, + state_slug, + gene, + role, + matched_to, + "observed_cirrhotic_GRN", + ) + ) + long = delta.stack().rename("delta_expression").reset_index() + long.columns = ["donor", "gene", "delta_expression"] + long.insert(0, "state_slug", state_slug) + long["perturb_gene"] = gene + long["role"] = role + long["matched_to"] = matched_to + long["network_type"] = "observed_cirrhotic_GRN" + gene_frames.append(long) + + for gene in active_targets: + delta = simulate(cirrhotic_expression, randomized, gene) + donor_frames.append( + summarize_delta( + delta, + disease_vector, + fra_weights, + state_slug, + gene, + "prespecified_candidate", + None, + "target_column_shuffled_GRN", + ) + ) + + donor_metrics = pd.concat(donor_frames, ignore_index=True) + donor_metrics.to_csv( + state_output / "donor_level_metrics.tsv", sep="\t", index=False + ) + summarize_donors(donor_metrics).to_csv( + state_output / "perturbation_summary.tsv", sep="\t", index=False + ) + pd.concat(gene_frames, ignore_index=True).to_csv( + state_output / "gene_level_signed_shifts.tsv.gz", + sep="\t", + index=False, + compression={"method": "gzip", "mtime": 0}, + ) + + adjusted_rows: list[dict[str, object]] = [] + for row_index, row in controls.iterrows(): + target = row["target"] + control = row["control"] + candidate_values = donor_metrics.loc[ + (donor_metrics["perturb_gene"] == target) + & (donor_metrics["network_type"] == "observed_cirrhotic_GRN") + ].set_index("donor")["fra_rescue_score"] + control_values = donor_metrics.loc[ + (donor_metrics["perturb_gene"] == control) + & (donor_metrics["network_type"] == "observed_cirrhotic_GRN") + ].set_index("donor")["fra_rescue_score"] + randomized_values = donor_metrics.loc[ + (donor_metrics["perturb_gene"] == target) + & (donor_metrics["network_type"] == "target_column_shuffled_GRN") + ].set_index("donor")["fra_rescue_score"] + donors = candidate_values.index.intersection(control_values.index).intersection( + randomized_values.index + ) + adjusted = candidate_values.loc[donors] - 0.5 * ( + control_values.loc[donors] + randomized_values.loc[donors] + ) + ci_low, ci_high = bootstrap_mean( + adjusted.to_numpy(), SEED + state_index * 100 + row_index + ) + adjusted_rows.append( + { + "state_slug": state_slug, + "target": target, + "matched_control": control, + "n_donors": len(adjusted), + "mean_fra_rescue_observed": candidate_values.loc[donors].mean(), + "mean_fra_rescue_matched_control": control_values.loc[donors].mean(), + "mean_fra_rescue_randomized_grn": randomized_values.loc[donors].mean(), + "mean_null_adjusted_fra_rescue": adjusted.mean(), + "bootstrap_ci_low": ci_low, + "bootstrap_ci_high": ci_high, + "n_donors_positive_adjusted_rescue": int((adjusted > 0).sum()), + "directional_rescue_supported": bool(ci_low > 0), + "native_method": "CellOracle_0.18.0_donor_mean_exact_propagation", + } + ) + pd.DataFrame(adjusted_rows).to_csv( + state_output / "candidate_null_adjusted_summary.tsv", sep="\t", index=False + ) + print(f"completed active={len(active_targets)} unavailable={unavailable}", flush=True) + return { + "state_slug": state_slug, + "candidate_path": str( + state_output / "candidate_null_adjusted_summary.tsv" + ), + } + except Exception: + traceback.print_exc() + raise + + +def main() -> None: + OUTPUT.mkdir(parents=True, exist_ok=True) + results: list[dict[str, str]] = [] + with ProcessPoolExecutor(max_workers=4) as executor: + futures = { + executor.submit(run_state, state, index): state + for index, state in enumerate(STATE_SLUGS, start=1) + } + for future in as_completed(futures): + results.append(future.result()) + + candidates = pd.concat( + [pd.read_csv(result["candidate_path"], sep="\t") for result in results], + ignore_index=True, + ).sort_values( + ["directional_rescue_supported", "mean_null_adjusted_fra_rescue"], + ascending=[False, False], + ) + candidates.insert(0, "celloracle_rank_v16", np.arange(1, len(candidates) + 1)) + candidates.to_csv( + OUTPUT / "celloracle_v16_ap1_runx2_ko.tsv", sep="\t", index=False + ) + report = [ + "# CellOracle v16 AP-1/RUNX2 orthogonal test", + "", + "- CellOracle 0.18.0 with the human promoter hg19 base GRN.", + "- Four states are modeled independently; healthy and cirrhotic GRNs are fitted separately to prevent cross-disease KNN smoothing.", + "- Each disease-state input uses 1,500 genes, within-disease balanced KNN imputation, and Ridge alpha=10.", + "- KO propagation uses the package's exact three-step signal-propagation function on each cirrhotic donor mean (five donor units where available).", + "- A higher FRA rescue score means a predicted decrease in the frozen regression-anchored FRA.", + "- Each candidate is calibrated against an expression/out-strength-matched TF KO and a target-column-shuffled GRN.", + "- `directional_rescue_supported` requires the donor bootstrap 95% interval of the null-adjusted FRA rescue to remain above zero.", + "- CellOracle can perturb only TFs with active outgoing edges in the fitted base-GRN-constrained model; non-TF candidates are assigned to scTenifold/scGPT.", + ] + (OUTPUT / "README.md").write_text("\n".join(report) + "\n") + + +if __name__ == "__main__": + main() diff --git a/code/perturbation/prepare_v16_hsc_control_perturbation.py b/code/perturbation/prepare_v16_hsc_control_perturbation.py new file mode 100644 index 0000000..e5781b7 --- /dev/null +++ b/code/perturbation/prepare_v16_hsc_control_perturbation.py @@ -0,0 +1,125 @@ +#!/usr/bin/env python3 +"""Prepare an HSC-only perturbation input with the v16 control architecture frozen.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import anndata as ad +import numpy as np +import pandas as pd +from scipy import sparse + + +REPO_ROOT = Path(__file__).resolve().parents[2] +SOURCE = REPO_ROOT / "data/raw_external/GSE136103/GSE136103_human_liver_cell_state_labels_v1.h5ad" +BASE = REPO_ROOT / "data/perturbation_inputs/hsc_myofibroblast" +OUT = REPO_ROOT / "work/perturbation_inputs" +STATE = "hsc_myofibroblast" +SEED = 20260711 +TARGETS = [ + "RUNX1", "RUNX2", "YAP1", "WWTR1", "TEAD1", "TEAD2", "TEAD3", "TEAD4", + "JUN", "FOS", "FOSL1", "FOSL2", "ETS1", "ETS2", "ITGB5", "GAS7", + "SPON1", "SVEP1", "PDGFRA", "LAMA2", "EPHA3", "DPYSL3", "LTBP2", + "EFEMP1", "SERPINE1", +] +EXPECTED_KO_DIRECTION = { + **{g: "rescue_expected" for g in ["RUNX1", "RUNX2", "YAP1", "WWTR1", "TEAD1", "TEAD2", "TEAD3", "TEAD4", "JUN", "FOS", "FOSL1", "FOSL2", "ITGB5", "GAS7", "SPON1", "SVEP1", "PDGFRA", "LAMA2", "EPHA3", "DPYSL3", "LTBP2", "EFEMP1", "SERPINE1"]}, + "ETS1": "worsening_expected", + "ETS2": "worsening_expected", +} + + +def balanced_positions(obs: pd.DataFrame, cap: int = 500) -> np.ndarray: + rng = np.random.default_rng(SEED) + selected = [] + for _, positions in obs.groupby(["disease", "donor"], observed=True).indices.items(): + positions = np.asarray(positions, int) + if len(positions) > cap: + positions = rng.choice(positions, cap, replace=False) + selected.extend(positions.tolist()) + return np.asarray(sorted(selected), int) + + +def collapse(matrix: sparse.csr_matrix, symbols: np.ndarray, genes: list[str]) -> sparse.csr_matrix: + old = np.flatnonzero(np.isin(symbols, genes)) + new_index = {g: i for i, g in enumerate(genes)} + columns = np.asarray([new_index[g] for g in symbols[old]], int) + mapper = sparse.csr_matrix( + (np.ones(len(old), np.float32), (np.arange(len(old)), columns)), + shape=(len(old), len(genes)), + ) + return (matrix[:, old].tocsr() @ mapper).tocsr().astype(np.float32) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--source-h5ad", type=Path, default=SOURCE) + parser.add_argument("--base-input-dir", type=Path, default=BASE) + parser.add_argument("--output-dir", type=Path, default=OUT) + return parser.parse_args() + + +def main() -> None: + global SOURCE, BASE, OUT + args = parse_args() + SOURCE, BASE, OUT = args.source_h5ad, args.base_input_dir, args.output_dir + out = OUT / STATE + out.mkdir(parents=True, exist_ok=True) + a = ad.read_h5ad(SOURCE) + mask = a.obs["cell_state_v1"].astype(str).eq("HSC_Myofibroblast").to_numpy() + state_positions = np.flatnonzero(mask) + local = balanced_positions(a.obs.iloc[state_positions]) + positions = state_positions[local] + obs = a.obs.iloc[positions].copy() + counts = a.layers["counts"][positions].tocsr() + symbols = a.var["gene_symbol"].fillna(a.var_names.to_series()).astype(str).str.upper().to_numpy() + base_genes = pd.read_csv(BASE / "scgpt_genes.tsv", header=None)[0].astype(str).str.upper().tolist() + detected = np.asarray((counts > 0).sum(axis=0)).ravel() + expressed_symbols = set(symbols[detected >= 10]) + targets = [g for g in TARGETS if g in expressed_symbols] + genes = list(dict.fromkeys(base_genes + targets)) + matrix = collapse(counts, symbols, genes) + sparse.save_npz(out / "scgpt_raw_counts_cells_by_genes.npz", matrix, compressed=True) + pd.Series(genes).to_csv(out / "scgpt_genes.tsv", sep="\t", index=False, header=False) + cells = pd.DataFrame({ + "cell": a.obs_names[positions].astype(str), + "donor": obs["donor"].astype(str).to_numpy(), + "disease": obs["disease"].astype(str).to_numpy(), + "cell_state_v1": obs["cell_state_v1"].astype(str).to_numpy(), + }) + cells.to_csv(out / "scgpt_cells.tsv", sep="\t", index=False) + cirrhotic = cells["disease"].eq("cirrhotic").to_numpy() + rows = [] + for gene in targets: + i = genes.index(gene) + values = matrix[:, i] + cvalues = matrix[cirrhotic, i] + detected_all = int(values.getnnz()) + detected_cirrhotic = int(cvalues.getnnz()) + donors = cells.loc[cirrhotic & (np.asarray(values.toarray()).ravel() > 0), "donor"].nunique() + rows.append({ + "state_slug": STATE, "target": gene, + "expected_ko_direction": EXPECTED_KO_DIRECTION[gene], + "detected_cells_all": detected_all, "detected_cells_cirrhotic": detected_cirrhotic, + "detected_cirrhotic_donors": int(donors), + }) + target_table = pd.DataFrame(rows) + target_table.to_csv(OUT / "perturbation_targets.tsv", sep="\t", index=False) + sampling = cells.groupby(["disease", "donor"]).size().rename("n_cells").reset_index() + sampling.to_csv(OUT / "sampling_manifest.tsv", sep="\t", index=False) + manifest = { + "source": str(SOURCE), "state": STATE, "seed": SEED, + "n_cells": int(len(cells)), "n_genes": int(len(genes)), + "targets_requested": TARGETS, "targets_in_input": targets, + "missing_or_detected_lt10": sorted(set(TARGETS) - set(targets)), + } + (OUT / "input_manifest.json").write_text(json.dumps(manifest, indent=2) + "\n") + print(json.dumps(manifest, indent=2)) + print(target_table.to_string(index=False)) + + +if __name__ == "__main__": + main() diff --git a/code/perturbation/scgpt_v16_hsc_control_perturbation.py b/code/perturbation/scgpt_v16_hsc_control_perturbation.py new file mode 100644 index 0000000..9db8a37 --- /dev/null +++ b/code/perturbation/scgpt_v16_hsc_control_perturbation.py @@ -0,0 +1,420 @@ +#!/usr/bin/env python3 +"""Run the frozen v16 HSC control-architecture scGPT value-ablation test.""" + +from __future__ import annotations + +import json +import os +import re +from pathlib import Path + +import numpy as np +import pandas as pd +import torch +from scipy import sparse +from scgpt.model import TransformerModel +from scgpt.preprocess import binning +from scgpt.tokenizer import GeneVocab, tokenize_and_pad_batch + + +REPO_ROOT = Path(__file__).resolve().parents[2] +ROOT = Path(os.environ.get("PN_ROOT", REPO_ROOT / "data/external_runtime")) +MODEL_DIR = ROOT / "00_raw/models_v15/scgpt_whole_human" +V16 = Path(os.environ.get("V16_ROOT", REPO_ROOT / "work/v16_runtime")) +INPUT_DIR = Path(os.environ.get("SCGPT_INPUT_DIR", V16 / "05_perturbation_inputs")) +OUTPUT = Path(os.environ.get("SCGPT_OUTPUT_DIR", V16 / "02_results/S7_hsc_control_perturbation/scgpt_primary")) +SEED = 20260710 +CELL_CAP_PER_DISEASE_DONOR = 200 +MIN_TARGET_CELLS = int(os.environ.get("MIN_TARGET_CELLS", "50")) +MIN_DONORS = int(os.environ.get("MIN_DONORS", "3")) +CONTROL_CODETECTION_FLOOR = float(os.environ.get("CONTROL_CODETECTION_FLOOR", "0")) + + +def build_model(vocab: GeneVocab, args: dict[str, object]) -> TransformerModel: + model = TransformerModel( + ntoken=len(vocab), + d_model=int(args["embsize"]), + nhead=int(args["nheads"]), + d_hid=int(args["d_hid"]), + nlayers=int(args["nlayers"]), + nlayers_cls=int(args.get("n_layers_cls", 3)), + n_cls=1, + vocab=vocab, + dropout=float(args.get("dropout", 0.2)), + pad_token=str(args.get("pad_token", "")), + pad_value=int(args.get("pad_value", -2)), + do_mvc=bool(args.get("MVC", True)), + do_dab=False, + use_batch_labels=False, + domain_spec_batchnorm=False, + input_emb_style=str(args.get("input_emb_style", "continuous")), + n_input_bins=int(args.get("n_bins", 51)), + cell_emb_style="cls", + ecs_threshold=0.0, + explicit_zero_prob=False, + use_fast_transformer=False, + pre_norm=False, + ) + raw = torch.load(MODEL_DIR / "best_model.pt", map_location="cpu", weights_only=True) + rules = { + r"self_attn\._impl\.Wqkv\.": "self_attn.in_proj_", + r"self_attn\.Wqkv\.": "self_attn.in_proj_", + r"self_attn\._impl\.out_proj\.": "self_attn.out_proj.", + } + renamed = {} + for key, value in raw.items(): + for pattern, replacement in rules.items(): + key = re.sub(pattern, replacement, key) + renamed[key] = value + state = model.state_dict() + compatible = { + key: value + for key, value in renamed.items() + if key in state and value.shape == state[key].shape + } + checkpoint_numel = sum(value.numel() for value in renamed.values()) + coverage = sum(value.numel() for value in compatible.values()) / checkpoint_numel + if coverage < 0.99: + raise RuntimeError(f"Checkpoint parameter coverage is {coverage:.4f}, expected >=0.99") + state.update(compatible) + model.load_state_dict(state) + return model + + +def select_cells(metadata: pd.DataFrame, state_index: int) -> np.ndarray: + rng = np.random.default_rng(SEED + state_index) + selected: list[int] = [] + for _, positions in metadata.groupby(["disease", "donor"], observed=True).indices.items(): + positions = np.asarray(positions, dtype=int) + if len(positions) > CELL_CAP_PER_DISEASE_DONOR: + positions = rng.choice(positions, CELL_CAP_PER_DISEASE_DONOR, replace=False) + selected.extend(positions.tolist()) + return np.asarray(sorted(selected), dtype=int) + + +def preprocess_counts(counts: sparse.csr_matrix, n_bins: int) -> np.ndarray: + totals = np.asarray(counts.sum(axis=1)).ravel() + scale = np.divide(1e4, totals, out=np.zeros_like(totals, dtype=float), where=totals > 0) + normalized = counts.multiply(scale[:, None]).tocsr() + normalized.data = np.log1p(normalized.data) + dense = normalized.toarray().astype(np.float32) + np.random.seed(SEED) + return np.vstack([binning(row, n_bins=n_bins) for row in dense]).astype(np.float32) + + +def choose_controls( + counts: sparse.csr_matrix, + genes: pd.Index, + metadata: pd.DataFrame, + targets: list[str], + excluded: set[str], +) -> pd.DataFrame: + cirrhotic = metadata["disease"].eq("cirrhotic").to_numpy() + matrix = counts[cirrhotic] + means = np.asarray(matrix.mean(axis=0)).ravel() + detection = np.asarray((matrix > 0).mean(axis=0)).ravel() + index = {gene: i for i, gene in enumerate(genes)} + selected: list[str] = [] + rows: list[dict[str, object]] = [] + for target in targets: + target_index = index[target] + target_cells = np.asarray(matrix[:, target_index].toarray()).ravel() > 0 + pool = [ + gene + for gene in genes + if gene not in excluded + and gene not in targets + and gene not in selected + and means[index[gene]] > 0 + and not gene.startswith(("MT-", "RPS", "RPL")) + ] + distances: dict[str, float] = {} + codetection: dict[str, float] = {} + for gene in pool: + gene_index = index[gene] + co = ( + float((np.asarray(matrix[target_cells, gene_index].toarray()).ravel() > 0).mean()) + if target_cells.sum() > 0 + else 0.0 + ) + codetection[gene] = co + distances[gene] = ( + abs(np.log1p(means[gene_index]) - np.log1p(means[target_index])) + + abs(detection[gene_index] - detection[target_index]) + + 0.5 * (1 - co) + ) + eligible = [gene for gene in pool if codetection[gene] >= CONTROL_CODETECTION_FLOOR] + if not eligible: + eligible = pool + control = min(eligible, key=distances.get) + selected.append(control) + rows.append( + { + "target": target, + "control": control, + "matching_distance": distances[control], + "cirrhotic_codetection": codetection[control], + "target_mean_count": means[target_index], + "control_mean_count": means[index[control]], + "target_detection": detection[target_index], + "control_detection": detection[index[control]], + "control_codetection_floor": CONTROL_CODETECTION_FLOOR, + } + ) + return pd.DataFrame(rows) + + +def infer_batches( + model: TransformerModel, + genes: torch.Tensor, + values: torch.Tensor, + pad_id: int, + device: torch.device, + batch_size: int, +) -> tuple[np.ndarray, np.ndarray]: + embeddings: list[np.ndarray] = [] + predictions: list[np.ndarray] = [] + for start in range(0, len(genes), batch_size): + end = min(start + batch_size, len(genes)) + batch_genes = genes[start:end].to(device, non_blocking=True) + batch_values = values[start:end].to(device, non_blocking=True) + padding = batch_genes.eq(pad_id) + with torch.inference_mode(), torch.autocast( + device_type="cuda", dtype=torch.bfloat16, enabled=True + ): + output = model(batch_genes, batch_values, padding, MVC=False) + embeddings.append(output["cell_emb"].float().cpu().numpy()) + predictions.append(output["mlm_output"].float().cpu().numpy()) + return np.vstack(embeddings), np.vstack(predictions) + + +def bootstrap_ci(values: np.ndarray, seed: int) -> tuple[float, float]: + rng = np.random.default_rng(seed) + estimates = np.mean(rng.choice(values, (5000, len(values)), replace=True), axis=1) + return tuple(np.quantile(estimates, [0.025, 0.975])) + + +def run_state( + state_slug: str, + state_index: int, + model: TransformerModel, + vocab: GeneVocab, + args: dict[str, object], + device: torch.device, + fra_weights: pd.Series, + excluded: set[str], +) -> tuple[pd.DataFrame, pd.DataFrame, pd.DataFrame]: + state_dir = INPUT_DIR / state_slug + counts = sparse.load_npz(state_dir / "scgpt_raw_counts_cells_by_genes.npz").tocsr() + genes = pd.Index(pd.read_csv(state_dir / "scgpt_genes.tsv", header=None)[0].astype(str)) + metadata = pd.read_csv(state_dir / "scgpt_cells.tsv", sep="\t") + selected = select_cells(metadata, state_index) + counts = counts[selected] + metadata = metadata.iloc[selected].reset_index(drop=True) + + vocabulary = set(vocab.get_stoi()) + keep = genes.isin(vocabulary) + counts = counts[:, keep] + genes = genes[keep] + targets_table = pd.read_csv(INPUT_DIR / "perturbation_targets.tsv", sep="\t") + targets = targets_table.loc[targets_table["state_slug"].eq(state_slug), "target"].unique().tolist() + if not set(targets).issubset(genes): + raise RuntimeError(f"Targets absent after vocab filtering in {state_slug}: {set(targets)-set(genes)}") + controls = choose_controls(counts, genes, metadata, targets, excluded) + + binned = preprocess_counts(counts, int(args["n_bins"])) + gene_ids = np.asarray([vocab[gene] for gene in genes], dtype=np.int64) + np.random.seed(SEED + state_index) + tokenized = tokenize_and_pad_batch( + binned, + gene_ids, + max_len=int(args["max_seq_len"]), + vocab=vocab, + pad_token=str(args["pad_token"]), + pad_value=int(args["pad_value"]), + append_cls=True, + include_zero_gene=False, + ) + token_genes = tokenized["genes"] + token_values = tokenized["values"] + batch_size = int(os.environ.get("SCGPT_BATCH_SIZE", "8")) + baseline_embedding, baseline_prediction = infer_batches( + model, token_genes, token_values, vocab[args["pad_token"]], device, batch_size + ) + healthy = metadata["disease"].eq("healthy").to_numpy() + cirrhotic = metadata["disease"].eq("cirrhotic").to_numpy() + healthy_centroid = baseline_embedding[healthy].mean(axis=0) + before_distance = np.linalg.norm(baseline_embedding - healthy_centroid, axis=1) + + fra_lookup = np.zeros(len(vocab), dtype=np.float32) + for gene, weight in fra_weights.items(): + if gene in vocab: + fra_lookup[vocab[gene]] = weight + fra_position_weights = fra_lookup[token_genes.numpy()] + cell_rows: list[pd.DataFrame] = [] + + for pair_index, pair in controls.iterrows(): + target, control = pair["target"], pair["control"] + target_present = token_genes.eq(vocab[target]) & token_values.gt(0) + control_present = token_genes.eq(vocab[control]) & token_values.gt(0) + usable = cirrhotic & target_present.any(dim=1).numpy() & control_present.any(dim=1).numpy() + usable_index = np.flatnonzero(usable) + usable_donors = metadata.loc[usable_index, "donor"].nunique() + if len(usable_index) < MIN_TARGET_CELLS or usable_donors < MIN_DONORS: + cell_rows.append( + pd.DataFrame( + { + "state_slug": [state_slug], + "target": [target], + "matched_control": [control], + "status": ["insufficient_joint_token_coverage"], + "n_cells": [len(usable_index)], + "n_donors": [usable_donors], + } + ) + ) + continue + + perturb_metrics = {} + for role, gene in (("target", target), ("matched_control", control)): + values = token_values[usable_index].clone() + gene_positions = token_genes[usable_index].eq(vocab[gene]) + values[gene_positions] = 0.0 + embedding, prediction = infer_batches( + model, + token_genes[usable_index], + values, + vocab[args["pad_token"]], + device, + batch_size, + ) + after_distance = np.linalg.norm(embedding - healthy_centroid, axis=1) + embedding_rescue = (before_distance[usable_index] - after_distance) / np.maximum( + before_distance[usable_index], 1e-8 + ) + prediction_delta = prediction - baseline_prediction[usable_index] + weights = fra_position_weights[usable_index] + fra_rescue = -np.divide( + (prediction_delta * weights).sum(axis=1), + weights.sum(axis=1), + out=np.full(len(usable_index), np.nan), + where=weights.sum(axis=1) > 0, + ) + perturb_metrics[role] = (embedding_rescue, fra_rescue) + + frame = metadata.loc[usable_index, ["cell", "donor"]].reset_index(drop=True) + frame.insert(0, "state_slug", state_slug) + frame["target"] = target + frame["matched_control"] = control + frame["status"] = "completed" + frame["n_cells"] = len(usable_index) + frame["n_donors"] = usable_donors + frame["target_embedding_rescue"] = perturb_metrics["target"][0] + frame["control_embedding_rescue"] = perturb_metrics["matched_control"][0] + frame["adjusted_embedding_rescue"] = ( + frame["target_embedding_rescue"] - frame["control_embedding_rescue"] + ) + frame["target_fra_decoder_rescue"] = perturb_metrics["target"][1] + frame["control_fra_decoder_rescue"] = perturb_metrics["matched_control"][1] + frame["adjusted_fra_decoder_rescue"] = ( + frame["target_fra_decoder_rescue"] - frame["control_fra_decoder_rescue"] + ) + cell_rows.append(frame) + + cells = pd.concat(cell_rows, ignore_index=True, sort=False) + complete = cells[cells["status"].eq("completed")].copy() + donor = ( + complete.groupby(["state_slug", "target", "matched_control", "donor"], observed=True)[ + ["adjusted_embedding_rescue", "adjusted_fra_decoder_rescue"] + ] + .mean() + .reset_index() + ) + summary_rows = [] + for key, frame in donor.groupby(["state_slug", "target", "matched_control"], observed=True): + row = dict(zip(["state_slug", "target", "matched_control"], key)) + row["n_donors"] = len(frame) + for metric in ["adjusted_embedding_rescue", "adjusted_fra_decoder_rescue"]: + values = frame[metric].dropna().to_numpy() + row[f"mean_{metric}"] = values.mean() if len(values) else np.nan + if len(values) >= 3: + low, high = bootstrap_ci(values, SEED + state_index) + else: + low, high = np.nan, np.nan + row[f"{metric}_ci_low"] = low + row[f"{metric}_ci_high"] = high + row["embedding_rescue_supported"] = row["adjusted_embedding_rescue_ci_low"] > 0 + row["fra_decoder_rescue_supported"] = row["adjusted_fra_decoder_rescue_ci_low"] > 0 + summary_rows.append(row) + summary = pd.DataFrame(summary_rows) + if not summary.empty: + summary = summary.merge( + controls, + left_on=["target", "matched_control"], + right_on=["target", "control"], + how="left", + ) + return cells, donor, summary + + +def main() -> None: + if not torch.cuda.is_available(): + raise RuntimeError("CUDA is required") + gpu_name = torch.cuda.get_device_name(0) + if "5090" not in gpu_name and os.environ.get("ALLOW_NON_5090") != "1": + raise RuntimeError(f"Refusing full run on {gpu_name}; switch to RTX 5090 or set ALLOW_NON_5090=1") + device = torch.device("cuda") + args = json.loads((MODEL_DIR / "args.json").read_text()) + vocab = GeneVocab.from_file(MODEL_DIR / "vocab.json") + vocab.set_default_index(vocab[args["pad_token"]]) + model = build_model(vocab, args).eval().to(device) + OUTPUT.mkdir(parents=True, exist_ok=True) + + fra = pd.read_csv(ROOT / "05_GRN/v15/fibrosis_reversibility_axis_v15.tsv", sep="\t") + fra_weights = ( + fra.loc[fra["fra_axis_weight"] > 0, ["gene_symbol", "fra_axis_weight"]] + .drop_duplicates("gene_symbol") + .set_index("gene_symbol")["fra_axis_weight"] + ) + axes = pd.read_csv(ROOT / "04_CCC_LR/v15/mechanism_axis_consensus.tsv", sep="\t") + excluded = set(fra["gene_symbol"].dropna().astype(str)) + excluded.update(axes["ligand"].dropna().astype(str)) + excluded.update(axes["receptor"].dropna().astype(str)) + + cell_frames, donor_frames, summary_frames = [], [], [] + targets_table = pd.read_csv(INPUT_DIR / "perturbation_targets.tsv", sep="\t") + state_slugs = targets_table["state_slug"].drop_duplicates().tolist() + for state_index, state_slug in enumerate(state_slugs, start=1): + cells, donors, summary = run_state( + state_slug, state_index, model, vocab, args, device, fra_weights, excluded + ) + cell_frames.append(cells) + donor_frames.append(donors) + summary_frames.append(summary) + pd.concat(cell_frames, ignore_index=True).to_csv( + OUTPUT / "scgpt_cell_level_metrics.tsv.gz", + sep="\t", + index=False, + compression={"method": "gzip", "mtime": 0}, + ) + pd.concat(donor_frames, ignore_index=True).to_csv( + OUTPUT / "scgpt_donor_level_metrics.tsv", sep="\t", index=False + ) + summary = pd.concat(summary_frames, ignore_index=True) + summary = summary.merge( + targets_table[["state_slug", "target", "expected_ko_direction"]].drop_duplicates(), + on=["state_slug", "target"], how="left", + ) + summary["directional_prediction_pass"] = np.where( + summary["expected_ko_direction"].eq("rescue_expected"), + (summary["mean_adjusted_embedding_rescue"] > 0) & (summary["mean_adjusted_fra_decoder_rescue"] > 0), + (summary["mean_adjusted_embedding_rescue"] < 0) & (summary["mean_adjusted_fra_decoder_rescue"] < 0), + ) + summary["gpu_name"] = gpu_name + summary["torch_version"] = torch.__version__ + summary["peak_gpu_memory_bytes"] = torch.cuda.max_memory_allocated() + summary.to_csv(OUTPUT / "scgpt_v16_hsc_control_perturb.tsv", sep="\t", index=False) + + +if __name__ == "__main__": + main() diff --git a/code/perturbation/sequential_basin_switch_drugs.py b/code/perturbation/sequential_basin_switch_drugs.py new file mode 100644 index 0000000..8598522 --- /dev/null +++ b/code/perturbation/sequential_basin_switch_drugs.py @@ -0,0 +1,233 @@ +#!/usr/bin/env python3 +"""Rank phase-ordered LINCS pairs by predicted basin-switching advantage.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import matplotlib.pyplot as plt +from matplotlib.patches import FancyBboxPatch +import numpy as np +import pandas as pd +import seaborn as sns + + +REPO_ROOT = Path(__file__).resolve().parents[2] +INPUT = REPO_ROOT / "data/LINCS_derived/LINCS_name_collapsed_hard_gated.tsv" +OUTPUT = REPO_ROOT / "results/S12_order_aware_drug_nomination" + +FOCUS = ["ezetimibe", "verteporfin", "wz-4002", "psb-069", "pioglitazone", "pre-084"] +EARLY_COLOR = "#238B8D" +LATE_COLOR = "#C33F55" +ORDER_COLOR = "#75558F" + + +def percentile(values: pd.Series) -> pd.Series: + return values.rank(method="average", pct=True) + + +def pair_score(early: pd.Series, late: pd.Series, early_retention_weight: float = 0.5, resolver_weight: float = 0.5, penalty_weight: float = 1.5) -> float: + endo = early.median_endo_support + 0.5 * late.median_endo_support + macro = early.median_macro_support + 0.5 * late.median_macro_support + retention = late.median_retention_suppression + early_retention_weight * early.median_retention_suppression + penalty = penalty_weight * max(0.0, -min(endo, macro)) + return float(retention + resolver_weight * endo + resolver_weight * macro - penalty) + + +def build_pairs(compounds: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame, pd.DataFrame]: + eligible = compounds.loc[ + compounds.identity_resolved.fillna(False) + & compounds.n_signatures.ge(3) + & compounds.n_cell_lines.ge(2) + & ~compounds.duplicate_id_conflict.fillna(False) + ].copy() + eligible["mean_resolver"] = 0.5 * (eligible.median_endo_support + eligible.median_macro_support) + early = eligible.loc[ + eligible.median_resolver_floor.ge(0.10) + & eligible.mean_resolver.ge(0.20) + & eligible.median_retention_suppression.ge(-0.10) + ].copy() + late = eligible.loc[ + eligible.median_retention_suppression.ge(0.20) + & eligible.q25_retention_suppression.ge(0.10) + & eligible.median_resolver_floor.ge(-0.15) + ].copy() + rows = [] + for _, e in early.iterrows(): + for _, l in late.iterrows(): + if e.pert_iname_norm == l.pert_iname_norm: + continue + forward = pair_score(e, l) + reverse = pair_score(l, e) + rows.append( + { + "early_compound": e.pert_iname_norm, + "late_compound": l.pert_iname_norm, + "forward_score": forward, + "reverse_score": reverse, + "order_advantage": forward - reverse, + "early_mean_resolver": e.mean_resolver, + "early_resolver_floor": e.median_resolver_floor, + "early_retention": e.median_retention_suppression, + "late_retention": l.median_retention_suppression, + "late_q25_retention": l.q25_retention_suppression, + "late_resolver_floor": l.median_resolver_floor, + "early_tier": e.translation_tier, + "late_tier": l.translation_tier, + "both_named": bool(e.named_identity and l.named_identity), + "both_hard_gate": bool(e.computational_hard_gate and l.computational_hard_gate), + } + ) + pairs = pd.DataFrame(rows) + pairs["forward_percentile"] = percentile(pairs.forward_score) + pairs["order_percentile"] = percentile(pairs.order_advantage) + pairs["basin_switch_index"] = 0.65 * pairs.forward_percentile + 0.35 * pairs.order_percentile + pairs["basin_switch_rank"] = pairs.basin_switch_index.rank(ascending=False, method="min").astype(int) + return eligible, early, pairs.sort_values("basin_switch_index", ascending=False) + + +def weight_sensitivity(early: pd.DataFrame, late: pd.DataFrame) -> pd.DataFrame: + rows = [] + for er in [0.25, 0.5, 0.75]: + for rw in [0.35, 0.5, 0.65]: + for pw in [1.0, 1.5, 2.0]: + local = [] + for _, e in early.iterrows(): + for _, l in late.iterrows(): + if e.pert_iname_norm == l.pert_iname_norm: + continue + forward = pair_score(e, l, er, rw, pw) + reverse = pair_score(l, e, er, rw, pw) + local.append((e.pert_iname_norm, l.pert_iname_norm, forward, forward - reverse)) + frame = pd.DataFrame(local, columns=["early", "late", "forward", "advantage"]) + frame["index"] = 0.65 * percentile(frame.forward) + 0.35 * percentile(frame.advantage) + frame["rank"] = frame["index"].rank(ascending=False, method="min") + target = frame.loc[frame.early.eq("ezetimibe") & frame.late.eq("verteporfin")] + if len(target): + row = target.iloc[0] + rows.append( + { + "early_retention_weight": er, + "resolver_weight": rw, + "penalty_weight": pw, + "forward_score": row.forward, + "order_advantage": row.advantage, + "basin_switch_index": row["index"], + "rank": int(row["rank"]), + "n_pairs": len(frame), + } + ) + return pd.DataFrame(rows) + + +def plot_results(eligible: pd.DataFrame, pairs: pd.DataFrame) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(15.5, 11.5)) + grid = fig.add_gridspec(2, 2, left=.07, right=.98, bottom=.07, top=.91, wspace=.30, hspace=.34) + + ax = fig.add_subplot(grid[0, 0]) + ax.scatter(eligible.mean_resolver, eligible.median_retention_suppression, s=15, color="#C7CDD0", alpha=.55) + for name in FOCUS: + local = eligible.loc[eligible.pert_iname_norm.eq(name)] + if len(local): + row = local.iloc[0] + ax.scatter(row.mean_resolver, row.median_retention_suppression, s=70, color=EARLY_COLOR if name=="ezetimibe" else LATE_COLOR, edgecolor="white", linewidth=.8, zorder=3) + ax.text(row.mean_resolver+.012,row.median_retention_suppression+.008,name,fontsize=8) + ax.axvline(.20,color=EARLY_COLOR,ls="--",lw=1); ax.axhline(.20,color=LATE_COLOR,ls="--",lw=1) + ax.set(xlabel="Mean endothelial/macrophage resolver support",ylabel="HSC-retention suppression") + ax.set_title("A Early and late controllers occupy different Pareto sectors",loc="left",fontweight="bold") + + ax = fig.add_subplot(grid[0, 1]) + named = pairs.loc[pairs.both_named].head(12).sort_values("order_advantage") + labels = named.early_compound + " → " + named.late_compound + y = np.arange(len(named)) + for yi, (_, row) in enumerate(named.iterrows()): + ax.plot([row.reverse_score,row.forward_score],[yi,yi],color="#AAB2B6",lw=2) + ax.scatter(row.reverse_score,yi,color="#7A8790",s=34,zorder=3) + ax.scatter(row.forward_score,yi,color=ORDER_COLOR,s=42,zorder=3) + ax.set_yticks(y,labels); ax.set_xlabel("Ordered pair score") + ax.set_title("B Sequence creates a directional control advantage",loc="left",fontweight="bold") + ax.text(.98,.04,"grey: reverse purple: forward",transform=ax.transAxes,ha="right",fontsize=8) + + ax = fig.add_subplot(grid[1, 0]) + early_names = pairs.groupby("early_compound").basin_switch_index.max().nlargest(10).index + late_names = pairs.groupby("late_compound").basin_switch_index.max().nlargest(10).index + heat = pairs.loc[pairs.early_compound.isin(early_names)&pairs.late_compound.isin(late_names)].pivot(index="early_compound",columns="late_compound",values="order_advantage") + heat = heat.reindex(index=early_names,columns=late_names) + sns.heatmap(heat,cmap="PRGn",center=0,annot=True,fmt=".2f",annot_kws={"fontsize":6},cbar_kws={"label":"Order advantage","shrink":.72},ax=ax) + ax.set(xlabel="Late lock suppressor",ylabel="Early resolver primer") + ax.set_title("C Ordered-pair control matrix",loc="left",fontweight="bold") + + ax = fig.add_subplot(grid[1, 1]) + target = pairs.loc[pairs.early_compound.eq("ezetimibe")&pairs.late_compound.eq("verteporfin")].iloc[0] + ax.set_axis_off(); ax.set_xlim(0,168); ax.set_ylim(0,1) + def band(start, end, y, label, color): + patch=FancyBboxPatch((start,y),end-start,.13,boxstyle="round,pad=0.012,rounding_size=2",fc=color,ec=color,lw=1) + ax.add_patch(patch); ax.text((start+end)/2,y+.065,label,ha="center",va="center",color="white",fontweight="bold",fontsize=8) + band(0,24,.75,"EZETIMIBE\nresolver priming",EARLY_COLOR) + band(24,72,.75,"VERTEPORFIN\nYAP/TEAD switching",LATE_COLOR) + band(72,168,.75,"PIOGLITAZONE\nstate stabilization","#C18C24") + ax.annotate("",xy=(24,.815),xytext=(20,.815),arrowprops=dict(arrowstyle="-|>",color="#454C50",lw=1.5)) + ax.annotate("",xy=(72,.815),xytext=(68,.815),arrowprops=dict(arrowstyle="-|>",color="#454C50",lw=1.5)) + rows=[ + (.57,"Endothelium","WNT9B · KLF2 · EMCN","#3182A6",0,28), + (.42,"Macrophage","TREM2 · GPNMB · MMP14","#4D8A63",0,34), + (.27,"HSC lock","YAP/TEAD · SERPINE1 · SPON1","#B83D4B",24,78), + (.12,"Durability","PPARγ quiescence · re-challenge threshold","#9B7421",72,168), + ] + for y,label,readout,color,start,end in rows: + ax.text(0,y,label,ha="left",va="center",fontweight="bold",color=color) + ax.plot([start,end],[y,y],color=color,lw=5,solid_capstyle="round",alpha=.78) + ax.text(min(end+3,166),y,readout,ha="left" if end<150 else "right",va="center",fontsize=7.5,color="#3F474B") + ax.text(166,.96,f"E → V {target.forward_score:.3f}\nV → E {target.reverse_score:.3f}\nΔorder {target.order_advantage:.3f}",ha="right",va="top",bbox=dict(boxstyle="round,pad=.35",fc="white",ec="#8D969C")) + ax.text(84,.02,"Equal cumulative exposure; compare simultaneous, forward and reverse order",ha="center",fontsize=8,color="#626C72") + ax.set_title("D Prime–switch–stabilize experiment",loc="left",fontweight="bold") + + for axis in fig.axes: + if axis.axison: + axis.spines[["top","right"]].set_visible(False) + fig.suptitle("Phase-ordered perturbations are predicted to switch the resolver–lock basin",fontsize=16,fontweight="bold") + fig.savefig(OUTPUT/"LINCS_sequential_basin_switch.png",dpi=320,facecolor="white") + fig.savefig(OUTPUT/"LINCS_sequential_basin_switch.pdf",facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser=argparse.ArgumentParser(description=__doc__) + parser.add_argument("--input",type=Path,default=INPUT) + parser.add_argument("--output-dir",type=Path,default=OUTPUT) + return parser.parse_args() + + +def main() -> None: + global INPUT,OUTPUT + args=parse_args() + INPUT,OUTPUT=args.input,args.output_dir + OUTPUT.mkdir(parents=True,exist_ok=True) + compounds=pd.read_csv(INPUT,sep="\t") + eligible,early,pairs=build_pairs(compounds) + late_names=pairs.late_compound.unique() + late=eligible.loc[eligible.pert_iname_norm.isin(late_names)].copy() + sensitivity=weight_sensitivity(early,late) + plot_results(eligible,pairs) + pairs.to_csv(OUTPUT/"LINCS_ordered_basin_switch_pairs.tsv",sep="\t",index=False) + sensitivity.to_csv(OUTPUT/"ezetimibe_verteporfin_weight_sensitivity.tsv",sep="\t",index=False) + target=pairs.loc[pairs.early_compound.eq("ezetimibe")&pairs.late_compound.eq("verteporfin")].iloc[0] + summary={ + "n_eligible_compounds":int(len(eligible)), + "n_early_primers":int(len(early)), + "n_late_suppressors":int(len(late)), + "n_ordered_pairs":int(len(pairs)), + "lead_pair":"ezetimibe -> verteporfin", + "lead_pair_metrics":target.to_dict(), + "weight_sensitivity":{"median_rank":float(sensitivity['rank'].median()),"best_rank":int(sensitivity['rank'].min()),"worst_rank":int(sensitivity['rank'].max()),"n_schemes":int(len(sensitivity))}, + "claim":"A prime-then-switch hypothesis with a strong computed direction advantage; designed for direct equal-exposure order testing.", + } + (OUTPUT/"sequential_basin_switch_summary.json").write_text(json.dumps(summary,indent=2,ensure_ascii=False)+"\n") + print(json.dumps(summary,indent=2,ensure_ascii=False)) + + +if __name__=="__main__": + main() diff --git a/code/perturbation/stage4_drug_hard_gate.py b/code/perturbation/stage4_drug_hard_gate.py new file mode 100644 index 0000000..4c5ee36 --- /dev/null +++ b/code/perturbation/stage4_drug_hard_gate.py @@ -0,0 +1,194 @@ +#!/usr/bin/env python3 +"""Collapse LINCS entities by compound name and apply robustness/safety gates.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd + + +HARD_EXCLUDE = { + "alvocidib", "aminopurvalanol-a", "cyclosporin-a", "dacinostat", "daunorubicin", + "digoxin", "doxorubicin", "geldanamycin", "menadione", "mitoxantrone", + "nsc-632839", "ouabain", "panobinostat", "prochlorperazine", "proscillaridin", "terfenadine", + "thiostrepton", "triclosan", +} +MECHANISTIC_PROBE = { + "verteporfin": "YAP/TEAD-mechanotransduction probe; independent HSC fibrosis evidence", + "WZ-4002": "EGFR-family kinase probe; tests growth-factor input into the retention attractor", + "tyrphostin-1": "broad receptor-tyrosine-kinase probe", + "U-0126": "MEK-ERK/AP-1 pathway probe", + "GDC-0941": "PI3K pathway probe", + "NVP-TAE684": "oncology kinase probe; experimental use only", + "NSC-632839": "deubiquitinase-pathway probe; toxicity gate required", + "PRE-084": "sigma-1 receptor probe; liver mechanism unresolved", + "forskolin": "cAMP/PKA probe; conflicts with reported PKA-RUNX2 activation", +} +TRANSLATION_ANCHOR = { + "pioglitazone": "PPAR-gamma re-quiescence/metabolic anchor", + "oxfendazole": "named repurposing candidate; mechanism and exposure review required", + "dehydrocholate": "bile-acid-context candidate; formulation and mechanism review required", + "ezetimibe": "metabolic translation anchor; dual-axis consistency review required", +} +REPO_ROOT = Path(__file__).resolve().parents[2] + + +def robust_z(x: pd.Series) -> pd.Series: + med = x.median() + mad = (x - med).abs().median() + scale = 1.4826 * mad if mad > 0 else x.std() + return (x - med) / (scale if scale and np.isfinite(scale) else 1) + + +def main() -> None: + ap = argparse.ArgumentParser() + ap.add_argument("--v16", type=Path, default=REPO_ROOT / "work/v16_runtime") + ap.add_argument("--legacy", type=Path, default=REPO_ROOT / "data/legacy_runtime") + args = ap.parse_args() + out = args.v16 / "02_results/S5_regulatory_drug_control" + sig = pd.read_csv(out / "LINCS_dual_axis_signature_scores.tsv.gz", sep="\t") + sig["pert_iname_norm"] = sig["pert_iname"].astype(str).str.strip().str.lower() + + per_id = sig.groupby(["pert_iname_norm", "pert_id"]).agg( + id_retention=("retention_suppression", "median"), + id_resolver_floor=("resolver_floor", "median"), + ).reset_index() + conflicts = per_id.groupby("pert_iname_norm").agg( + n_pert_ids=("pert_id", "nunique"), min_id_retention=("id_retention", "min"), + max_id_retention=("id_retention", "max"), min_id_resolver_floor=("id_resolver_floor", "min"), + max_id_resolver_floor=("id_resolver_floor", "max"), + ).reset_index() + conflicts["retention_direction_conflict_across_ids"] = (conflicts["min_id_retention"] < 0) & (conflicts["max_id_retention"] > 0) + conflicts["resolver_direction_conflict_across_ids"] = (conflicts["min_id_resolver_floor"] < 0) & (conflicts["max_id_resolver_floor"] > 0) + + d = sig.groupby("pert_iname_norm").agg( + pert_iname=("pert_iname", "first"), pert_ids=("pert_id", lambda x: ";".join(sorted(set(map(str, x))))), + n_signatures=("sig_id", "nunique"), n_cell_lines=("cell_id", "nunique"), + cell_lines=("cell_id", lambda x: ";".join(sorted(set(map(str, x))))), + median_retention_suppression=("retention_suppression", "median"), + q25_retention_suppression=("retention_suppression", lambda x: x.quantile(.25)), + median_endo_support=("endothelial_resolution_support", "median"), + median_macro_support=("macrophage_resolution_support", "median"), + median_resolver_floor=("resolver_floor", "median"), + median_dual_control=("dual_control_score", "median"), + q25_dual_control=("dual_control_score", lambda x: x.quantile(.25)), + fraction_dual_positive=("dual_positive", "mean"), + ).reset_index().merge(conflicts, on="pert_iname_norm", how="left") + d = d[(d["n_signatures"] >= 3) & (d["n_cell_lines"] >= 2)].copy() + d["robust_dual"] = d["median_dual_control"] + .5 * d["q25_dual_control"] + d["concurrent_score"] = robust_z(d["robust_dual"]) + robust_z(d["fraction_dual_positive"]) + d["early_score"] = robust_z(d[["median_endo_support", "median_macro_support"]].mean(axis=1)) + .5 * robust_z(d["median_resolver_floor"]) + d["late_score"] = robust_z(d["median_retention_suppression"]) + .5 * robust_z(d["q25_retention_suppression"]) + d["concurrent_rank"] = d["concurrent_score"].rank(ascending=False, method="min").astype(int) + + sensitivity = [] + for wr, we, wm in [(1, .5, .5), (1.5, .25, .25), (.75, .75, .75), (1, 1, 0), (1, 0, 1)]: + score = wr * d["median_retention_suppression"] + we * d["median_endo_support"] + wm * d["median_macro_support"] + rank = score.rank(ascending=False, method="min") + for idx in d.index: + sensitivity.append((idx, int(rank.loc[idx]))) + sens = pd.DataFrame(sensitivity, columns=["idx", "rank"]).groupby("idx").agg( + median_sensitivity_rank=("rank", "median"), worst_sensitivity_rank=("rank", "max"), + n_top50_schemes=("rank", lambda x: int((x <= 50).sum())), + ) + d = d.join(sens, how="left") + + pert = pd.read_csv(args.legacy / "00_raw/cmap_lincs/GSE92742/GSE92742_pert_info.txt.gz", sep="\t", dtype=str) + pert["pert_iname_norm"] = pert["pert_iname"].astype(str).str.strip().str.lower() + identity = pert[pert["pert_type"].eq("trt_cp")].groupby("pert_iname_norm").agg( + is_touchstone=("is_touchstone", lambda x: int(pd.to_numeric(x, errors="coerce").fillna(0).max())), + has_structure=("canonical_smiles", lambda x: bool((x.astype(str) != "-666").any())), + pubchem_cids=("pubchem_cid", lambda x: ";".join(sorted(set(v for v in map(str, x) if v != "-666")))), + ).reset_index() + d = d.merge(identity, on="pert_iname_norm", how="left") + d["named_identity"] = ~d["pert_iname"].astype(str).str.upper().str.startswith("BRD-") + d["identity_resolved"] = d["named_identity"] & (d["has_structure"].fillna(False) | d["is_touchstone"].eq(1)) + d["duplicate_id_conflict"] = d["retention_direction_conflict_across_ids"] | d["resolver_direction_conflict_across_ids"] + d["safety_gate"] = "manual_review_required" + d.loc[d["pert_iname_norm"].isin(HARD_EXCLUDE), "safety_gate"] = "exclude_narrow_margin_or_cytotoxic" + d.loc[d["pert_iname"].isin(MECHANISTIC_PROBE), "safety_gate"] = "mechanistic_probe_only" + d.loc[d["pert_iname_norm"].isin(TRANSLATION_ANCHOR), "safety_gate"] = "translation_review" + d["mechanism_context"] = d["pert_iname"].map(MECHANISTIC_PROBE).fillna(d["pert_iname_norm"].map(TRANSLATION_ANCHOR)).fillna("unresolved_or_not_curated") + + d["computational_hard_gate"] = ( + d["identity_resolved"] & ~d["duplicate_id_conflict"] + & (d["median_retention_suppression"] > 0) & (d["median_resolver_floor"] > 0) + & (d["fraction_dual_positive"] >= .5) & (d["n_top50_schemes"] >= 2) + ) + d["translation_tier"] = "Tier_4_not_prioritized" + d.loc[d["computational_hard_gate"], "translation_tier"] = "Tier_3_computational_hit" + d.loc[d["computational_hard_gate"] & d["safety_gate"].eq("mechanistic_probe_only"), "translation_tier"] = "Tier_1_mechanistic_probe" + d.loc[(d["concurrent_rank"] <= 40) & d["pert_iname_norm"].isin(TRANSLATION_ANCHOR) & ~d["duplicate_id_conflict"], "translation_tier"] = "Tier_2_translation_anchor" + d.loc[d["safety_gate"].eq("exclude_narrow_margin_or_cytotoxic"), "translation_tier"] = "Excluded_safety" + d = d.sort_values(["translation_tier", "concurrent_rank"]) + d.to_csv(out / "LINCS_name_collapsed_hard_gated.tsv", sep="\t", index=False) + + eligible = d[ + d["computational_hard_gate"] + & ~d["safety_gate"].eq("exclude_narrow_margin_or_cytotoxic") + & ~d["pert_iname_norm"].isin({"estradiol"}) + ].copy() + early = eligible.nlargest(25, "early_score") + late = eligible.nlargest(25, "late_score") + pairs = [] + for _, e in early.iterrows(): + for _, l in late.iterrows(): + if e["pert_iname_norm"] == l["pert_iname_norm"]: + continue + pr = l["median_retention_suppression"] + .5 * e["median_retention_suppression"] + pe = e["median_endo_support"] + .5 * l["median_endo_support"] + pm = e["median_macro_support"] + .5 * l["median_macro_support"] + score = pr + .5 * pe + .5 * pm - 1.5 * max(0, -min(pe, pm)) + mechanism_resolved = e["pert_iname"] in MECHANISTIC_PROBE and l["pert_iname"] in MECHANISTIC_PROBE + pairs.append({"early_resolver_compound": e["pert_iname"], "late_retention_compound": l["pert_iname"], "phase_selective_pair_score": score, "early_resolver_floor": e["median_resolver_floor"], "late_retention_suppression": l["median_retention_suppression"], "both_mechanisms_curated": mechanism_resolved, "interpretation": "ordered additive hypothesis; not synergy"}) + pairs = pd.DataFrame(pairs).sort_values(["both_mechanisms_curated", "phase_selective_pair_score"], ascending=[False, False]) + rng = np.random.default_rng(20260711) + null = [] + vals = eligible.reset_index(drop=True) + for _ in range(20000): + i, j = rng.choice(len(vals), 2, replace=False) + e, l = vals.iloc[i], vals.iloc[j] + pr = l["median_retention_suppression"] + .5 * e["median_retention_suppression"] + pe = e["median_endo_support"] + .5 * l["median_endo_support"] + pm = e["median_macro_support"] + .5 * l["median_macro_support"] + null.append(pr + .5 * pe + .5 * pm - 1.5 * max(0, -min(pe, pm))) + null = np.asarray(null) + pairs["random_eligible_pair_percentile"] = [(null <= x).mean() for x in pairs["phase_selective_pair_score"]] + pairs.to_csv(out / "LINCS_phase_pairs_hard_gated.tsv", sep="\t", index=False) + + fig, axes = plt.subplots(1, 2, figsize=(13, 5.5), constrained_layout=True) + plot = d.copy() + resolver = plot[["median_endo_support", "median_macro_support"]].mean(axis=1) + colors = plot["translation_tier"].map({"Tier_1_mechanistic_probe": "#D1495B", "Tier_2_translation_anchor": "#00798C", "Tier_3_computational_hit": "#EDAE49", "Excluded_safety": "#777777"}).fillna("#D5D5D5") + axes[0].scatter(plot["median_retention_suppression"], resolver, c=colors, s=18, alpha=.65) + axes[0].axhline(0, color="#777", lw=.8); axes[0].axvline(0, color="#777", lw=.8) + label = plot[plot["translation_tier"].isin(["Tier_1_mechanistic_probe", "Tier_2_translation_anchor"])].nsmallest(12, "concurrent_rank") + for _, r in label.iterrows(): + axes[0].text(r["median_retention_suppression"], np.mean([r["median_endo_support"], r["median_macro_support"]]), r["pert_iname"], fontsize=8) + axes[0].set(xlabel="HSC retention suppression", ylabel="Mean resolver support", title="A Name-collapsed, hard-gated compounds") + top = pairs.head(12).iloc[::-1] + axes[1].barh(np.arange(len(top)), top["phase_selective_pair_score"], color="#4D908E") + axes[1].set_yticks(np.arange(len(top)), [f"{a} -> {b}" for a, b in zip(top["early_resolver_compound"], top["late_retention_compound"])], fontsize=7) + axes[1].set(xlabel="Ordered additive control score", title="B Phase-selective hypotheses after safety gate") + fig.savefig(args.v16 / "03_figures/Figure_v16_drug_hard_gate.png", dpi=300, bbox_inches="tight") + fig.savefig(args.v16 / "03_figures/Figure_v16_drug_hard_gate.pdf", bbox_inches="tight") + plt.close(fig) + + summary = { + "name_collapsed_compounds": int(len(d)), "duplicate_id_conflicts": int(d["duplicate_id_conflict"].sum()), + "computational_hard_gate": int(d["computational_hard_gate"].sum()), + "tier1_mechanistic": d[d["translation_tier"].eq("Tier_1_mechanistic_probe")]["pert_iname"].tolist(), + "tier2_translation": d[d["translation_tier"].eq("Tier_2_translation_anchor")]["pert_iname"].tolist(), + "top_pairs": pairs.head(20).to_dict("records"), + } + (out / "stage4_hard_gate_summary.json").write_text(json.dumps(summary, indent=2) + "\n") + print(json.dumps(summary, indent=2)) + + +if __name__ == "__main__": + main() diff --git a/code/perturbation/stage4_regulatory_drug_control.py b/code/perturbation/stage4_regulatory_drug_control.py new file mode 100644 index 0000000..0c13f6b --- /dev/null +++ b/code/perturbation/stage4_regulatory_drug_control.py @@ -0,0 +1,465 @@ +#!/usr/bin/env python3 +"""Build the v16 regulatory-switch and phase-selective drug-control layer.""" + +from __future__ import annotations + +import argparse +import itertools +import json +import math +import os +import re +import subprocess +import time +import urllib.parse +import urllib.request +from concurrent.futures import ThreadPoolExecutor, as_completed +from pathlib import Path + +import h5py +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +from scipy.stats import fisher_exact + + +RETENTION_GENES = [ + "ITGB5", "GAS7", "SPON1", "SVEP1", "PDGFRA", "LAMA2", "EPHA3", + "DPYSL3", "LTBP2", "EFEMP1", "SERPINE1", "COL1A1", "COL3A1", + "LOXL2", "ACTA2", "TIMP1", "THBS2", "FBLN5", +] +ENDO_RESOLVER_GENES = [ + "WNT9B", "WNT7B", "VWF", "ACE", "KDR", "ESAM", "EMCN", "PLVAP", + "KLF2", "NR2F2", +] +MACRO_RESOLVER_GENES = [ + "TREM2", "GPNMB", "LPL", "MMP14", "CTSB", "CTSD", "AXL", "MERTK", +] +REGULATORY_CANDIDATES = [ + "ITGB5", "GAS7", "SPON1", "SVEP1", "PDGFRA", "LAMA2", "EPHA3", + "DPYSL3", "LTBP2", "EFEMP1", "SERPINE1", +] + +# Consensus sequences are taken directly from the authors' HOMER table. +MOTIF_CONSENSUS = { + "AP1": ["VTGACTCATC", "GATGASTCATCN", "NDATGASTCAYN"], + "RUNX": ["SAAACCACAG", "AAACCACARM", "NWAACCACADNN"], + "ETS": ["ACAGGAAGTG", "AACCGGAAGT", "NRYTTCCGGH"], +} +IUPAC = { + "A": "A", "C": "C", "G": "G", "T": "T", "R": "[AG]", "Y": "[CT]", + "S": "[GC]", "W": "[AT]", "K": "[GT]", "M": "[AC]", "B": "[CGT]", + "D": "[AGT]", "H": "[ACT]", "V": "[ACG]", "N": "[ACGT]", +} +COMPLEMENT = str.maketrans("ACGTRYSWKMBDHVN", "TGCAYRSWMKVHDBN") +REPO_ROOT = Path(__file__).resolve().parents[2] + + +def parse_args() -> argparse.Namespace: + p = argparse.ArgumentParser() + p.add_argument("--v16", type=Path, default=REPO_ROOT / "work/v16_runtime") + p.add_argument("--legacy", type=Path, default=REPO_ROOT / "data/legacy_runtime") + p.add_argument("--gctx", type=Path, default=REPO_ROOT / "data/raw_external/LINCS/GSE92742_Level5_COMPZ.MODZ.gctx") + p.add_argument("--skip-drugs", action="store_true") + return p.parse_args() + + +def read_excel_table(path: Path, sheet: str, skiprows: int) -> pd.DataFrame: + d = pd.read_excel(path, sheet_name=sheet, skiprows=skiprows) + if "PeakID" not in d.columns: + unnamed = [c for c in d.columns if str(c).startswith("Unnamed:")] + described = [c for c in d.columns if str(c).startswith("PeakID (")] + if unnamed: + d = d.rename(columns={unnamed[0]: "PeakID"}) + elif described: + d = d.rename(columns={described[0]: "PeakID"}) + if described and described[0] in d.columns and described[0] != "PeakID": + d = d.rename(columns={described[0]: "PeakID_annotation_command"}) + return d.dropna(how="all").reset_index(drop=True) + + +def annotation_class(value: object) -> str: + s = str(value).lower() + if "promoter" in s or "tts" in s or "utr" in s or "exon" in s: + return "promoter_or_genic_boundary" + if "intron" in s: + return "intron" + return "intergenic" + + +def select_matched_controls(peaks: pd.DataFrame, candidates: pd.DataFrame, k: int = 12) -> pd.DataFrame: + pool = peaks[~peaks["Gene Name"].astype(str).str.upper().isin(REGULATORY_CANDIDATES)].copy() + for d in (pool, candidates): + d["length"] = pd.to_numeric(d["End"], errors="coerce") - pd.to_numeric(d["Start"], errors="coerce") + d["abs_tss"] = pd.to_numeric(d["Distance to TSS"], errors="coerce").abs().fillna(1e6) + d["lfc"] = pd.to_numeric(d["avg_log2FC"], errors="coerce").fillna(0) + d["ann_class"] = d["Annotation"].map(annotation_class) + used: set[str] = set() + selected = [] + for _, c in candidates.sort_values(["Gene Name", "p_val_adj", "avg_log2FC"]).iterrows(): + q = pool[~pool["PeakID"].astype(str).isin(used)].copy() + q["distance"] = ( + np.abs(np.log1p(q["length"]) - math.log1p(c["length"])) + + np.abs(np.log1p(q["abs_tss"]) - math.log1p(c["abs_tss"])) + + np.abs(q["lfc"] - c["lfc"]) + + 1.5 * (q["ann_class"] != c["ann_class"]).astype(float) + + 0.5 * (q["Chr"] != c["Chr"]).astype(float) + ) + take = q.nsmallest(k, "distance").copy() + take["matched_to_peak"] = c["PeakID"] + take["matched_to_gene"] = c["Gene Name"] + used.update(take["PeakID"].astype(str)) + selected.append(take) + return pd.concat(selected, ignore_index=True) if selected else pool.iloc[0:0] + + +def fetch_ucsc_sequence(row: dict, retries: int = 4) -> tuple[str, str]: + peak = str(row["PeakID"]) + params = urllib.parse.urlencode({ + "genome": "hg38", "chrom": row["Chr"], "start": int(row["Start"]), "end": int(row["End"]), + }) + url = "https://api.genome.ucsc.edu/getData/sequence?" + params + for attempt in range(retries): + try: + ucsc_ip = os.environ.get("UCSC_API_IP") + if ucsc_ip: + completed = subprocess.run( + ["curl", "--resolve", f"api.genome.ucsc.edu:443:{ucsc_ip}", "-fsSL", "--max-time", "30", url], + check=True, capture_output=True, text=True, + ) + payload = json.loads(completed.stdout) + else: + with urllib.request.urlopen(url, timeout=30) as r: + payload = json.load(r) + return peak, str(payload["dna"]).upper() + except Exception: + if attempt == retries - 1: + raise + time.sleep(1.5 * (attempt + 1)) + raise RuntimeError("unreachable") + + +def get_sequences(rows: pd.DataFrame, cache_path: Path) -> dict[str, str]: + cache = json.loads(cache_path.read_text()) if cache_path.exists() else {} + unique = rows.drop_duplicates("PeakID") + todo = [r._asdict() for r in unique.itertuples(index=False) if str(r.PeakID) not in cache] + if todo: + with ThreadPoolExecutor(max_workers=8) as ex: + futures = [ex.submit(fetch_ucsc_sequence, r) for r in todo] + for i, fut in enumerate(as_completed(futures), 1): + peak, sequence = fut.result() + cache[peak] = sequence + if i % 100 == 0: + cache_path.write_text(json.dumps(cache)) + cache_path.write_text(json.dumps(cache)) + return cache + + +def reverse_complement_iupac(sequence: str) -> str: + return sequence.translate(COMPLEMENT)[::-1] + + +def consensus_regex(consensus: str) -> re.Pattern[str]: + return re.compile("".join(IUPAC[x] for x in consensus.upper())) + + +def motif_hit(sequence: str, consensuses: list[str]) -> bool: + for motif in consensuses: + for query in (motif, reverse_complement_iupac(motif)): + if consensus_regex(query).search(sequence): + return True + return False + + +def family_from_motif(name: str) -> str | None: + u = name.upper() + if "RUNX" in u: + return "RUNX" + if any(x in u for x in ("AP-1", "FOS", "FRA", "JUN")): + return "AP1" + if any(x in u for x in ("ETS1", "ERG(", "FLI1", "ETV", "GABPA", "ETS(ETS)")): + return "ETS" + return None + + +def regulatory_analysis(v16: Path, out: Path) -> tuple[pd.DataFrame, pd.DataFrame]: + xdir = v16 / "00_raw/GSE244832/literature/xlsx" + s9 = read_excel_table(xdir / "1-s2.0-S0168827824026679-mmc11.xlsx", "Table S9", 7) + s9["Gene Name"] = s9["Gene Name"].astype(str).str.upper() + activated = s9[s9["cluster"].eq("A")].copy() + candidates = activated[activated["Gene Name"].isin(REGULATORY_CANDIDATES)].copy() + candidates = candidates.sort_values(["Gene Name", "p_val_adj", "avg_log2FC"], ascending=[True, True, False]) + controls = select_matched_controls(activated, candidates) + candidates["set"] = "retention_locus" + controls["set"] = "matched_activated_peak" + all_peaks = pd.concat([candidates, controls], ignore_index=True) + sequences = get_sequences(all_peaks, out / "hg38_peak_sequence_cache.json") + for fam, consensuses in MOTIF_CONSENSUS.items(): + all_peaks[f"{fam}_hit"] = all_peaks["PeakID"].astype(str).map( + lambda x: motif_hit(sequences.get(x, ""), consensuses) + ) + all_peaks.to_csv(out / "retention_locus_matched_motif_scan.tsv", sep="\t", index=False) + + family_rows = [] + motif_book = xdir / "1-s2.0-S0168827824026679-mmc13.xlsx" + for cluster in ("A", "Q", "INF"): + motifs = pd.read_excel(motif_book, sheet_name=cluster) + motifs["family"] = motifs["Motif Name"].astype(str).map(family_from_motif) + motifs = motifs[motifs["family"].notna()].copy() + motifs["target_pct"] = pd.to_numeric(motifs["% of Target Sequences with Motif"].astype(str).str.rstrip("%"), errors="coerce") + motifs["background_pct"] = pd.to_numeric(motifs["% of Background Sequences with Motif"].astype(str).str.rstrip("%"), errors="coerce") + motifs["enrichment_or"] = (motifs["target_pct"] / (100 - motifs["target_pct"])) / (motifs["background_pct"] / (100 - motifs["background_pct"])) + for fam, d in motifs.groupby("family"): + r = d.sort_values("P-value").iloc[0] + family_rows.append({ + "cluster": cluster, "family": fam, "representative_motif": r["Motif Name"], + "consensus": r["Consensus"], "p_value": r["P-value"], + "target_pct": r["target_pct"], "background_pct": r["background_pct"], + "global_enrichment_or": r["enrichment_or"], + }) + family = pd.DataFrame(family_rows) + family.to_csv(out / "HSC_state_motif_family_enrichment.tsv", sep="\t", index=False) + + matched_rows = [] + cand = all_peaks[all_peaks["set"].eq("retention_locus")] + ctrl = all_peaks[all_peaks["set"].eq("matched_activated_peak")] + for fam in MOTIF_CONSENSUS: + a = int(cand[f"{fam}_hit"].sum()) + b = int(len(cand) - a) + c = int(ctrl[f"{fam}_hit"].sum()) + d = int(len(ctrl) - c) + odds, p = fisher_exact([[a, b], [c, d]], alternative="greater") + matched_rows.append({ + "family": fam, "candidate_hits": a, "candidate_total": len(cand), + "control_hits": c, "control_total": len(ctrl), "matched_odds_ratio": odds, + "fisher_one_sided_p": p, + }) + matched = pd.DataFrame(matched_rows) + matched.to_csv(out / "retention_locus_motif_matched_null.tsv", sep="\t", index=False) + + a_global = family[family["cluster"].eq("A")].set_index("family")["global_enrichment_or"].to_dict() + edges = [] + for gene, d in cand.groupby("Gene Name"): + for fam in MOTIF_CONSENSUS: + hits = d[d[f"{fam}_hit"]] + if hits.empty: + continue + strongest = hits.sort_values(["p_val_adj", "avg_log2FC"], ascending=[True, False]).iloc[0] + score = float(strongest["avg_log2FC"]) + math.log2(max(a_global.get(fam, 1), 1e-6)) + 0.5 * math.log2(1 + len(hits)) + edges.append({ + "tf_family": fam, "gene": gene, "n_candidate_peaks": len(d), + "n_motif_positive_peaks": len(hits), "strongest_peak": strongest["PeakID"], + "peak_log2fc_A_vs_rest": strongest["avg_log2FC"], "peak_fdr_A_vs_rest": strongest["p_val_adj"], + "nearest_gene_distance_to_tss": strongest["Distance to TSS"], + "global_A_motif_enrichment_or": a_global.get(fam), "locus_edge_score": score, + "edge_semantics": "motif-supported nearest-gene locus edge", + }) + edges = pd.DataFrame(edges).sort_values("locus_edge_score", ascending=False) + edges.to_csv(out / "HSC_retention_regulatory_locus_edges.tsv", sep="\t", index=False) + return family, edges + + +def decode(values: np.ndarray) -> list[str]: + return [x.decode() if isinstance(x, (bytes, np.bytes_)) else str(x) for x in values] + + +def robust_z(series: pd.Series) -> pd.Series: + med = series.median() + mad = (series - med).abs().median() + scale = 1.4826 * mad if mad > 0 else series.std() + return (series - med) / (scale if scale and np.isfinite(scale) else 1) + + +def drug_analysis(v16: Path, legacy: Path, gctx: Path, out: Path) -> tuple[pd.DataFrame, pd.DataFrame, pd.DataFrame]: + cmap = legacy / "02_results/CMap" + gene_info = pd.read_csv(legacy / "00_raw/cmap_lincs/GSE92742/GSE92742_gene_info.txt.gz", sep="\t", dtype=str) + gene_info["symbol"] = gene_info["pr_gene_symbol"].str.upper() + symbol_to_id = gene_info.drop_duplicates("symbol").set_index("symbol")["pr_gene_id"].to_dict() + candidates = pd.read_csv(cmap / "LINCS_candidate_liver_or_hepatic_signatures.tsv", sep="\t", low_memory=False) + candidates = candidates[candidates["pert_type"].eq("trt_cp")].drop_duplicates("sig_id") + + sets = {"retention": RETENTION_GENES, "endo": ENDO_RESOLVER_GENES, "macro": MACRO_RESOLVER_GENES} + rows = [] + with h5py.File(gctx, "r") as h: + matrix = h["0/DATA/0/matrix"] + sig_ids = decode(h["0/META/COL/id"][:]) + gene_ids = decode(h["0/META/ROW/id"][:]) + sig_index = {s: i for i, s in enumerate(sig_ids)} + gene_index = {g: i for i, g in enumerate(gene_ids)} + candidates = candidates[candidates["sig_id"].astype(str).isin(sig_index)].copy() + set_cols = {} + for name, genes in sets.items(): + mapped = [(g, symbol_to_id.get(g)) for g in genes] + set_cols[name] = [(g, gene_index[e]) for g, e in mapped if e in gene_index] + (out / "dual_axis_gene_mapping.json").write_text(json.dumps({k: [g for g, _ in v] for k, v in set_cols.items()}, indent=2) + "\n") + all_cols = sorted({i for values in set_cols.values() for _, i in values}) + positions = {name: [all_cols.index(i) for _, i in values] for name, values in set_cols.items()} + indexed = sorted((sig_index[s], s) for s in candidates["sig_id"].astype(str)) + for start in range(0, len(indexed), 1000): + batch = indexed[start:start + 1000] + data = matrix[[i for i, _ in batch], :][:, all_cols].astype(np.float64) + means = {name: np.nanmean(data[:, pos], axis=1) for name, pos in positions.items()} + for j, (_, sid) in enumerate(batch): + retention = -float(means["retention"][j]) + endo = float(means["endo"][j]) + macro = float(means["macro"][j]) + resolver_floor = min(endo, macro) + dual = retention + 0.5 * endo + 0.5 * macro - 1.5 * max(0, -resolver_floor) + rows.append({ + "sig_id": sid, "retention_suppression": retention, + "endothelial_resolution_support": endo, "macrophage_resolution_support": macro, + "resolver_floor": resolver_floor, "dual_control_score": dual, + }) + signature = pd.DataFrame(rows).merge(candidates, on="sig_id", how="left") + signature["dual_positive"] = (signature["retention_suppression"] > 0) & (signature["resolver_floor"] >= 0) + signature.to_csv(out / "LINCS_dual_axis_signature_scores.tsv.gz", sep="\t", index=False, compression="gzip") + + agg = signature.groupby(["pert_id", "pert_iname"], dropna=False).agg( + n_signatures=("sig_id", "nunique"), n_cell_lines=("cell_id", "nunique"), + cell_lines=("cell_id", lambda x: ";".join(sorted(set(map(str, x))))), + median_retention_suppression=("retention_suppression", "median"), + q25_retention_suppression=("retention_suppression", lambda x: x.quantile(.25)), + median_endo_support=("endothelial_resolution_support", "median"), + median_macro_support=("macrophage_resolution_support", "median"), + median_resolver_floor=("resolver_floor", "median"), + median_dual_control=("dual_control_score", "median"), + q25_dual_control=("dual_control_score", lambda x: x.quantile(.25)), + fraction_dual_positive=("dual_positive", "mean"), + ).reset_index() + agg = agg[(agg["n_signatures"] >= 3) & (agg["n_cell_lines"] >= 2)].copy() + agg["robust_dual_control"] = agg["median_dual_control"] + 0.5 * agg["q25_dual_control"] + agg["concurrent_score"] = robust_z(agg["robust_dual_control"]) + robust_z(agg["fraction_dual_positive"]) + agg["early_resolver_score"] = robust_z(agg[["median_endo_support", "median_macro_support"]].mean(axis=1)) + 0.5 * robust_z(agg["median_resolver_floor"]) + agg["late_retention_score"] = robust_z(agg["median_retention_suppression"]) + 0.5 * robust_z(agg["q25_retention_suppression"]) + + annotation_path = legacy / "06_CMap_LINCS/drug_reverse_score_trt_cp_annotated_top500.tsv" + if annotation_path.exists(): + ann = pd.read_csv(annotation_path, sep="\t", low_memory=False) + keys = [c for c in ["pert_id", "pert_iname"] if c in ann.columns] + useful = keys + [c for c in ann.columns if any(x in c.lower() for x in ("moa", "target", "safety", "identity"))] + ann = ann[useful].drop_duplicates(keys) + agg = agg.merge(ann, on=keys, how="left", suffixes=("", "_annotation")) + agg = agg.sort_values("concurrent_score", ascending=False) + agg["concurrent_rank"] = np.arange(1, len(agg) + 1) + agg["early_resolver_rank"] = agg["early_resolver_score"].rank(ascending=False, method="min").astype(int) + agg["late_retention_rank"] = agg["late_retention_score"].rank(ascending=False, method="min").astype(int) + agg.to_csv(out / "LINCS_dual_axis_compound_ranking.tsv", sep="\t", index=False) + + early = agg[(agg["median_resolver_floor"] > 0) & (agg["median_retention_suppression"] > -0.25)].nsmallest(30, "early_resolver_rank") + late = agg[(agg["median_retention_suppression"] > 0) & (agg["median_resolver_floor"] > -0.25)].nsmallest(30, "late_retention_rank") + pairs = [] + for _, e in early.iterrows(): + for _, l in late.iterrows(): + if e["pert_id"] == l["pert_id"]: + continue + pair_ret = l["median_retention_suppression"] + 0.5 * e["median_retention_suppression"] + pair_endo = e["median_endo_support"] + 0.5 * l["median_endo_support"] + pair_macro = e["median_macro_support"] + 0.5 * l["median_macro_support"] + score = pair_ret + 0.5 * pair_endo + 0.5 * pair_macro - 1.5 * max(0, -min(pair_endo, pair_macro)) + pairs.append({ + "early_resolver_compound": e["pert_iname"], "early_pert_id": e["pert_id"], + "late_retention_compound": l["pert_iname"], "late_pert_id": l["pert_id"], + "predicted_pair_retention_suppression": pair_ret, + "predicted_pair_endo_support": pair_endo, "predicted_pair_macro_support": pair_macro, + "phase_selective_pair_score": score, + "interpretation": "ordered additive hypothesis; not a synergy estimate", + }) + pairs = pd.DataFrame(pairs).sort_values("phase_selective_pair_score", ascending=False) + null_scores = [] + rng = np.random.default_rng(20260711) + eligible = agg.index.to_numpy() + for _ in range(20000): + i, j = rng.choice(eligible, 2, replace=False) + e, l = agg.loc[i], agg.loc[j] + pr = l["median_retention_suppression"] + .5 * e["median_retention_suppression"] + pe = e["median_endo_support"] + .5 * l["median_endo_support"] + pm = e["median_macro_support"] + .5 * l["median_macro_support"] + null_scores.append(pr + .5 * pe + .5 * pm - 1.5 * max(0, -min(pe, pm))) + null = np.asarray(null_scores) + pairs["random_pair_percentile"] = [float((null <= x).mean()) for x in pairs["phase_selective_pair_score"]] + pairs.to_csv(out / "LINCS_phase_selective_ordered_pairs.tsv", sep="\t", index=False) + + sens = [] + for w_ret, w_endo, w_macro in [(1, .5, .5), (1.5, .25, .25), (.75, .75, .75), (1, 1, 0), (1, 0, 1)]: + score = w_ret * agg["median_retention_suppression"] + w_endo * agg["median_endo_support"] + w_macro * agg["median_macro_support"] + rank = score.rank(ascending=False, method="min") + for idx in agg.nsmallest(100, "concurrent_rank").index: + sens.append({"pert_id": agg.loc[idx, "pert_id"], "pert_iname": agg.loc[idx, "pert_iname"], "weight_scheme": f"{w_ret}:{w_endo}:{w_macro}", "rank": int(rank.loc[idx])}) + sensitivity = pd.DataFrame(sens) + stability = sensitivity.groupby(["pert_id", "pert_iname"]).agg(median_sensitivity_rank=("rank", "median"), worst_sensitivity_rank=("rank", "max"), n_top50_schemes=("rank", lambda x: int((x <= 50).sum()))).reset_index() + stability.to_csv(out / "LINCS_dual_axis_weight_sensitivity.tsv", sep="\t", index=False) + return agg, pairs, signature + + +def make_figure(family: pd.DataFrame, edges: pd.DataFrame, compounds: pd.DataFrame, pairs: pd.DataFrame, out: Path) -> None: + fig, axes = plt.subplots(2, 2, figsize=(14, 11), constrained_layout=True) + colors = {"A": "#C7472E", "Q": "#2A6F97", "INF": "#6A994E"} + ax = axes[0, 0] + pivot = family.pivot(index="family", columns="cluster", values="global_enrichment_or").reindex(["AP1", "RUNX", "ETS"]) + x = np.arange(len(pivot)) + for i, cl in enumerate(["A", "Q", "INF"]): + ax.bar(x + (i - 1) * .23, pivot[cl], width=.22, color=colors[cl], label=cl) + ax.axhline(1, color="black", lw=.8) + ax.set_xticks(x, pivot.index) + ax.set_ylabel("Target/background motif odds ratio") + ax.set_title("A HSC state regulatory architecture", loc="left", fontweight="bold") + ax.legend(frameon=False) + + ax = axes[0, 1] + if not edges.empty: + matrix = edges.pivot_table(index="gene", columns="tf_family", values="locus_edge_score", aggfunc="max").reindex(columns=["AP1", "RUNX", "ETS"]) + matrix = matrix.loc[matrix.max(axis=1).sort_values(ascending=False).index] + im = ax.imshow(matrix.fillna(0), cmap="YlOrRd", aspect="auto") + ax.set_yticks(np.arange(len(matrix)), matrix.index, fontsize=8) + ax.set_xticks(np.arange(len(matrix.columns)), matrix.columns) + fig.colorbar(im, ax=ax, fraction=.04, label="Motif-supported locus edge score") + ax.set_title("B Candidate retention loci", loc="left", fontweight="bold") + + ax = axes[1, 0] + plot = compounds.copy() + resolver = plot[["median_endo_support", "median_macro_support"]].mean(axis=1) + ax.scatter(plot["median_retention_suppression"], resolver, c=plot["fraction_dual_positive"], cmap="viridis", s=18, alpha=.55) + ax.axhline(0, color="#777777", lw=.8) + ax.axvline(0, color="#777777", lw=.8) + for _, r in plot.nsmallest(10, "concurrent_rank").iterrows(): + ax.text(r["median_retention_suppression"], np.mean([r["median_endo_support"], r["median_macro_support"]]), str(r["pert_iname"]), fontsize=7) + ax.set_xlabel("HSC retention suppression") + ax.set_ylabel("Mean resolver support") + ax.set_title("C LINCS dual-control landscape", loc="left", fontweight="bold") + + ax = axes[1, 1] + top = pairs.head(12).iloc[::-1] + labels = [f"{a} -> {b}" for a, b in zip(top["early_resolver_compound"], top["late_retention_compound"])] + ax.barh(np.arange(len(top)), top["phase_selective_pair_score"], color="#4D908E") + ax.set_yticks(np.arange(len(top)), labels, fontsize=7) + ax.set_xlabel("Ordered additive control score") + ax.set_title("D Phase-selective intervention hypotheses", loc="left", fontweight="bold") + fig.suptitle("Regulatory and pharmacologic control of the scar-interface reaction front", fontsize=16, fontweight="bold") + fig.savefig(out / "Figure_v16_regulatory_drug_control.png", dpi=300, bbox_inches="tight") + fig.savefig(out / "Figure_v16_regulatory_drug_control.pdf", bbox_inches="tight") + plt.close(fig) + + +def main() -> None: + args = parse_args() + out = args.v16 / "02_results/S5_regulatory_drug_control" + figdir = args.v16 / "03_figures" + out.mkdir(parents=True, exist_ok=True) + figdir.mkdir(parents=True, exist_ok=True) + family, edges = regulatory_analysis(args.v16, out) + if args.skip_drugs: + return + compounds, pairs, signature = drug_analysis(args.v16, args.legacy, args.gctx, out) + make_figure(family, edges, compounds, pairs, figdir) + summary = { + "regulatory_edges": int(len(edges)), "compounds_robustly_scored": int(len(compounds)), + "signatures_scored": int(len(signature)), "ordered_pairs_scored": int(len(pairs)), + "top_concurrent": compounds.head(20)[["pert_iname", "concurrent_score"]].to_dict("records"), + "top_ordered_pairs": pairs.head(20)[["early_resolver_compound", "late_retention_compound", "phase_selective_pair_score", "random_pair_percentile"]].to_dict("records"), + } + (out / "stage4_summary.json").write_text(json.dumps(summary, indent=2, default=str) + "\n") + print(json.dumps(summary, indent=2, default=str)) + + +if __name__ == "__main__": + main() diff --git a/code/perturbation/v15_celloracle_native_cpu.py b/code/perturbation/v15_celloracle_native_cpu.py new file mode 100755 index 0000000..5428cf3 --- /dev/null +++ b/code/perturbation/v15_celloracle_native_cpu.py @@ -0,0 +1,450 @@ +#!/usr/bin/env python3 +"""Run state-specific native CellOracle TF knockout simulations on donor means.""" + +from __future__ import annotations + +import contextlib +import os +import traceback +from concurrent.futures import ProcessPoolExecutor, as_completed +from pathlib import Path + +import anndata as ad +import celloracle as co +import numpy as np +import pandas as pd +from scipy import sparse, stats + +from celloracle.trajectory.oracle_GRN import _do_simulation + + +REPO_ROOT = Path(__file__).resolve().parents[2] +ROOT = Path(os.environ.get("PN_ROOT", REPO_ROOT / "data/external_runtime")) +INPUT = ROOT / "01_scRNA/v15/perturbation_inputs" +OUTPUT = ROOT / "05_GRN/v15/celloracle_native" +BASE_GRN = ( + ROOT + / "00_raw/models_v15/celloracle/" + / "human_promoter_base_GRN_hg19_gimmemotifsv5_fpr2.parquet" +) +SEED = 20260710 +STATE_SLUGS = [ + "hsc_myofibroblast", + "endothelial", + "macrophage_kupffer", + "cholangiocyte", +] + + +def build_oracle(adata: ad.AnnData, disease: str, seed: int) -> co.Oracle: + np.random.seed(seed) + subset = adata[adata.obs["disease"].astype(str).eq(disease)].copy() + subset.obs["donor"] = subset.obs["donor"].astype(str).astype("category") + oracle = co.Oracle() + oracle.import_anndata_as_raw_count( + subset, + cluster_column_name="donor", + embedding_name="X_umap", + transform="natural_log", + ) + oracle.import_TF_data(TF_info_matrix_path=str(BASE_GRN)) + n_components = min(50, subset.n_obs - 1, subset.n_vars - 1) + oracle.perform_PCA(n_components=n_components) + k = max(10, min(50, int(subset.n_obs * 0.025))) + oracle.knn_imputation( + k=k, + n_pca_dims=min(40, n_components), + balanced=True, + b_sight=min(k * 8, subset.n_obs - 1), + b_maxl=min(k * 4, subset.n_obs - 1), + n_jobs=3, + ) + oracle.fit_GRN_for_simulation( + GRN_unit="whole", alpha=10, use_cluster_specific_TFdict=False, verbose_level=0 + ) + return oracle + + +def donor_means(oracle: co.Oracle) -> pd.DataFrame: + expression = oracle.adata.to_df(layer="imputed_count") + expression["__donor"] = oracle.adata.obs["donor"].astype(str).to_numpy() + return expression.groupby("__donor", observed=True).mean() + + +def choose_controls( + coefficient: pd.DataFrame, + expression: pd.DataFrame, + targets: list[str], + excluded: set[str], +) -> pd.DataFrame: + out_strength = coefficient.abs().sum(axis=1) + mean_expression = expression.mean(axis=0) + pool = [ + gene + for gene in coefficient.index + if gene not in excluded + and gene not in targets + and out_strength.get(gene, 0) > 0 + and mean_expression.get(gene, 0) > 0.02 + and not gene.startswith(("MT-", "RPS", "RPL")) + ] + selected: list[str] = [] + rows: list[dict[str, object]] = [] + for target in targets: + candidates = [gene for gene in pool if gene not in selected] + if not candidates: + raise RuntimeError(f"No matched-control pool remains for {target}") + target_degree = np.log1p(out_strength[target]) + target_expression = np.log1p(mean_expression[target]) + distances = { + gene: abs(np.log1p(out_strength[gene]) - target_degree) + + abs(np.log1p(mean_expression[gene]) - target_expression) + for gene in candidates + } + control = min(distances, key=distances.get) + selected.append(control) + rows.append( + { + "target": target, + "control": control, + "target_out_strength": out_strength[target], + "control_out_strength": out_strength[control], + "target_mean_expression": mean_expression[target], + "control_mean_expression": mean_expression[control], + "matching_distance": distances[control], + } + ) + return pd.DataFrame(rows) + + +def cosine(left: np.ndarray, right: np.ndarray) -> float: + denominator = np.linalg.norm(left) * np.linalg.norm(right) + if denominator == 0: + return np.nan + return float(np.dot(left, right) / denominator) + + +def simulate( + expression: pd.DataFrame, + coefficient: pd.DataFrame, + gene: str, +) -> pd.DataFrame: + simulation_input = expression.copy() + simulation_input.loc[:, gene] = 0.0 + simulated = _do_simulation( + coef_matrix=coefficient, + simulation_input=simulation_input, + gem=expression, + n_propagation=3, + ) + return simulated - expression + + +def summarize_delta( + delta: pd.DataFrame, + disease_vector: pd.Series, + fra_weights: pd.Series, + state_slug: str, + perturb_gene: str, + role: str, + matched_to: str | None, + network_type: str, +) -> pd.DataFrame: + fra_genes = fra_weights.index.intersection(delta.columns) + weights = fra_weights.loc[fra_genes] + weights = weights / weights.sum() + rows: list[dict[str, object]] = [] + for donor, values in delta.iterrows(): + fra_delta = values.loc[fra_genes] + disease = disease_vector.loc[fra_genes] + rows.append( + { + "state_slug": state_slug, + "donor": donor, + "perturb_gene": perturb_gene, + "role": role, + "matched_to": matched_to, + "network_type": network_type, + "fra_rescue_score": -float(np.average(fra_delta, weights=weights)), + "fra_down_fraction": float((fra_delta < 0).mean()), + "fra_disease_reversal_cosine": cosine( + fra_delta.to_numpy(), -disease.to_numpy() + ), + "global_disease_reversal_cosine": cosine( + values.to_numpy(), -disease_vector.loc[values.index].to_numpy() + ), + "rms_shift": float(np.sqrt(np.mean(values.to_numpy() ** 2))), + "target_delta": float(values.get(perturb_gene, np.nan)), + } + ) + return pd.DataFrame(rows) + + +def summarize_donors(donor_metrics: pd.DataFrame) -> pd.DataFrame: + keys = ["state_slug", "perturb_gene", "role", "matched_to", "network_type"] + metrics = [ + "fra_rescue_score", + "fra_down_fraction", + "fra_disease_reversal_cosine", + "global_disease_reversal_cosine", + "rms_shift", + "target_delta", + ] + rows: list[dict[str, object]] = [] + for key, frame in donor_metrics.groupby(keys, dropna=False, observed=True): + row = dict(zip(keys, key)) + row["n_donors"] = len(frame) + for metric in metrics: + values = frame[metric].dropna().to_numpy(float) + row[f"mean_{metric}"] = np.mean(values) if len(values) else np.nan + row[f"sd_{metric}"] = np.std(values, ddof=1) if len(values) > 1 else np.nan + rescue = frame["fra_rescue_score"].dropna().to_numpy(float) + row["n_donors_positive_fra_rescue"] = int((rescue > 0).sum()) + row["fra_rescue_ttest_p"] = ( + stats.ttest_1samp(rescue, popmean=0).pvalue if len(rescue) >= 3 else np.nan + ) + rows.append(row) + return pd.DataFrame(rows) + + +def bootstrap_mean(values: np.ndarray, seed: int) -> tuple[float, float]: + rng = np.random.default_rng(seed) + estimates = np.mean( + rng.choice(values, size=(5000, len(values)), replace=True), axis=1 + ) + return tuple(np.quantile(estimates, [0.025, 0.975])) + + +def run_state(state_slug: str, state_index: int) -> dict[str, str]: + state_output = OUTPUT / state_slug + state_output.mkdir(parents=True, exist_ok=True) + log_path = state_output / "run.log" + with log_path.open("w") as log, contextlib.redirect_stdout(log), contextlib.redirect_stderr(log): + try: + print(f"state={state_slug} seed={SEED + state_index}", flush=True) + adata = ad.read_h5ad(INPUT / state_slug / "celloracle_input.h5ad") + targets_table = pd.read_csv(INPUT / "perturbation_targets.tsv", sep="\t") + targets = targets_table.loc[ + (targets_table["state_slug"] == state_slug) + & (targets_table["method"] == "CellOracle"), + "target", + ].tolist() + fra = pd.read_csv( + ROOT / "05_GRN/v15/fibrosis_reversibility_axis_v15.tsv", sep="\t" + ) + fra_weights = ( + fra.loc[fra["fra_axis_weight"] > 0, ["gene_symbol", "fra_axis_weight"]] + .drop_duplicates("gene_symbol") + .set_index("gene_symbol")["fra_axis_weight"] + ) + axes = pd.read_csv( + ROOT / "04_CCC_LR/v15/mechanism_axis_consensus.tsv", sep="\t" + ) + excluded = set(fra["gene_symbol"].dropna().astype(str)) + excluded.update(axes["ligand"].dropna().astype(str)) + excluded.update(axes["receptor"].dropna().astype(str)) + + healthy = build_oracle(adata, "healthy", SEED + state_index * 10 + 1) + cirrhotic = build_oracle(adata, "cirrhotic", SEED + state_index * 10 + 2) + healthy_expression = donor_means(healthy) + cirrhotic_expression = donor_means(cirrhotic) + disease_vector = cirrhotic_expression.mean() - healthy_expression.mean() + coefficient = cirrhotic.coef_matrix.copy() + healthy_coefficient = healthy.coef_matrix.copy() + + genes = coefficient.index.astype(str) + pd.Series(genes).to_csv(state_output / "coefficient_genes.tsv", index=False, header=False) + sparse.save_npz( + state_output / "cirrhotic_coefficient_matrix.npz", + sparse.csr_matrix(coefficient.to_numpy()), + compressed=True, + ) + sparse.save_npz( + state_output / "healthy_coefficient_matrix.npz", + sparse.csr_matrix(healthy_coefficient.loc[genes, genes].to_numpy()), + compressed=True, + ) + + active_targets = [ + gene + for gene in targets + if gene in coefficient.index and coefficient.loc[gene].abs().sum() > 0 + ] + unavailable = sorted(set(targets) - set(active_targets)) + pd.DataFrame( + { + "target": targets, + "status": [ + "active_cirrhotic_GRN" if gene in active_targets else "no_outgoing_cirrhotic_edge" + for gene in targets + ], + } + ).to_csv(state_output / "target_availability.tsv", sep="\t", index=False) + if not active_targets: + raise RuntimeError(f"No active CellOracle targets in {state_slug}: {unavailable}") + + controls = choose_controls( + coefficient, cirrhotic_expression, active_targets, excluded + ) + controls.to_csv( + state_output / "degree_expression_matched_controls.tsv", sep="\t", index=False + ) + cirrhotic.calculate_randomized_coef_table() + randomized = cirrhotic.coef_matrix_randomized.copy() + + donor_frames: list[pd.DataFrame] = [] + gene_frames: list[pd.DataFrame] = [] + perturbations = [ + (gene, "prespecified_candidate", None) for gene in active_targets + ] + [ + (row.control, "degree_expression_matched_null", row.target) + for row in controls.itertuples(index=False) + ] + for gene, role, matched_to in perturbations: + delta = simulate(cirrhotic_expression, coefficient, gene) + donor_frames.append( + summarize_delta( + delta, + disease_vector, + fra_weights, + state_slug, + gene, + role, + matched_to, + "observed_cirrhotic_GRN", + ) + ) + long = delta.stack().rename("delta_expression").reset_index() + long.columns = ["donor", "gene", "delta_expression"] + long.insert(0, "state_slug", state_slug) + long["perturb_gene"] = gene + long["role"] = role + long["matched_to"] = matched_to + long["network_type"] = "observed_cirrhotic_GRN" + gene_frames.append(long) + + for gene in active_targets: + delta = simulate(cirrhotic_expression, randomized, gene) + donor_frames.append( + summarize_delta( + delta, + disease_vector, + fra_weights, + state_slug, + gene, + "prespecified_candidate", + None, + "target_column_shuffled_GRN", + ) + ) + + donor_metrics = pd.concat(donor_frames, ignore_index=True) + donor_metrics.to_csv( + state_output / "donor_level_metrics.tsv", sep="\t", index=False + ) + summarize_donors(donor_metrics).to_csv( + state_output / "perturbation_summary.tsv", sep="\t", index=False + ) + pd.concat(gene_frames, ignore_index=True).to_csv( + state_output / "gene_level_signed_shifts.tsv.gz", + sep="\t", + index=False, + compression={"method": "gzip", "mtime": 0}, + ) + + adjusted_rows: list[dict[str, object]] = [] + for row_index, row in controls.iterrows(): + target = row["target"] + control = row["control"] + candidate_values = donor_metrics.loc[ + (donor_metrics["perturb_gene"] == target) + & (donor_metrics["network_type"] == "observed_cirrhotic_GRN") + ].set_index("donor")["fra_rescue_score"] + control_values = donor_metrics.loc[ + (donor_metrics["perturb_gene"] == control) + & (donor_metrics["network_type"] == "observed_cirrhotic_GRN") + ].set_index("donor")["fra_rescue_score"] + randomized_values = donor_metrics.loc[ + (donor_metrics["perturb_gene"] == target) + & (donor_metrics["network_type"] == "target_column_shuffled_GRN") + ].set_index("donor")["fra_rescue_score"] + donors = candidate_values.index.intersection(control_values.index).intersection( + randomized_values.index + ) + adjusted = candidate_values.loc[donors] - 0.5 * ( + control_values.loc[donors] + randomized_values.loc[donors] + ) + ci_low, ci_high = bootstrap_mean( + adjusted.to_numpy(), SEED + state_index * 100 + row_index + ) + adjusted_rows.append( + { + "state_slug": state_slug, + "target": target, + "matched_control": control, + "n_donors": len(adjusted), + "mean_fra_rescue_observed": candidate_values.loc[donors].mean(), + "mean_fra_rescue_matched_control": control_values.loc[donors].mean(), + "mean_fra_rescue_randomized_grn": randomized_values.loc[donors].mean(), + "mean_null_adjusted_fra_rescue": adjusted.mean(), + "bootstrap_ci_low": ci_low, + "bootstrap_ci_high": ci_high, + "n_donors_positive_adjusted_rescue": int((adjusted > 0).sum()), + "directional_rescue_supported": bool(ci_low > 0), + "native_method": "CellOracle_0.18.0_donor_mean_exact_propagation", + } + ) + pd.DataFrame(adjusted_rows).to_csv( + state_output / "candidate_null_adjusted_summary.tsv", sep="\t", index=False + ) + print(f"completed active={len(active_targets)} unavailable={unavailable}", flush=True) + return { + "state_slug": state_slug, + "candidate_path": str( + state_output / "candidate_null_adjusted_summary.tsv" + ), + } + except Exception: + traceback.print_exc() + raise + + +def main() -> None: + OUTPUT.mkdir(parents=True, exist_ok=True) + results: list[dict[str, str]] = [] + with ProcessPoolExecutor(max_workers=4) as executor: + futures = { + executor.submit(run_state, state, index): state + for index, state in enumerate(STATE_SLUGS, start=1) + } + for future in as_completed(futures): + results.append(future.result()) + + candidates = pd.concat( + [pd.read_csv(result["candidate_path"], sep="\t") for result in results], + ignore_index=True, + ).sort_values( + ["directional_rescue_supported", "mean_null_adjusted_fra_rescue"], + ascending=[False, False], + ) + candidates.insert(0, "celloracle_rank_v15", np.arange(1, len(candidates) + 1)) + candidates.to_csv( + ROOT / "05_GRN/v15/celloracle_native_ko.tsv", sep="\t", index=False + ) + report = [ + "# Native CellOracle v15", + "", + "- CellOracle 0.18.0 with the human promoter hg19 base GRN.", + "- Four states are modeled independently; healthy and cirrhotic GRNs are fitted separately to prevent cross-disease KNN smoothing.", + "- Each disease-state input uses 1,500 genes, within-disease balanced KNN imputation, and Ridge alpha=10.", + "- KO propagation uses the package's exact three-step signal-propagation function on each cirrhotic donor mean (five donor units where available).", + "- A higher FRA rescue score means a predicted decrease in the frozen regression-anchored FRA.", + "- Each candidate is calibrated against an expression/out-strength-matched TF KO and a target-column-shuffled GRN.", + "- `directional_rescue_supported` requires the donor bootstrap 95% interval of the null-adjusted FRA rescue to remain above zero.", + "- CellOracle can perturb only TFs with active outgoing edges in the fitted base-GRN-constrained model; non-TF candidates are assigned to scTenifold/scGPT.", + ] + (OUTPUT / "README.md").write_text("\n".join(report) + "\n") + + +if __name__ == "__main__": + main() diff --git a/code/public_mechanism/UQ_Visium_resolver_window_analysis.py b/code/public_mechanism/UQ_Visium_resolver_window_analysis.py new file mode 100644 index 0000000..bbb218c --- /dev/null +++ b/code/public_mechanism/UQ_Visium_resolver_window_analysis.py @@ -0,0 +1,600 @@ +#!/usr/bin/env python3 +"""Test scar-proximal retention/resolution balance across human MASLD fibrosis stages.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import h5py +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +import seaborn as sns +import statsmodels.api as sm +from scipy import stats +from scipy.sparse import csc_matrix +from scipy.spatial import cKDTree + + +MODULES = { + "ECM_scar": ["COL1A1", "COL1A2", "COL3A1", "COL6A1", "DCN", "LUM", "SPARC", "THBS2", "TIMP1", "LOXL2", "ACTA2", "TAGLN"], + "HSC_identity": ["RGS5", "PDGFRB", "CSPG4", "DES", "COL6A1", "NOTCH3"], + "Endo_identity": ["PECAM1", "CDH5", "RAMP2", "EGFL7", "ENG", "ERG", "TEK", "ROBO4"], + "Myeloid_identity": ["LST1", "TYROBP", "FCER1G", "AIF1", "CTSS", "SPI1", "CD68"], + "HSC_retention": ["ITGB5", "GAS7", "SPON1", "SVEP1", "PDGFRA", "LAMA2", "EPHA3", "DPYSL3", "LTBP2", "EFEMP1", "SERPINE1"], + "Endo_resolver": ["WNT9B", "WNT7B", "VWF", "ACE", "KDR", "ESAM", "EMCN", "PLVAP", "KLF2", "NR2F2"], + "LAM_resolver": ["TREM2", "GPNMB", "LPL", "MMP14", "CTSB", "CTSD", "AXL", "MERTK"], + "AP1_control": ["FOS", "JUN", "JUNB", "JUND", "FOSL1", "FOSL2"], + "TGFb_integrator": ["TGFB1", "TGFBR1", "TGFBR2", "SMAD3", "SMAD7", "CTGF", "CCN2", "THBS1"], +} + +OUTCOMES = { + "HSC_retention": ["HSC_identity", "log_library"], + "Endo_resolver": ["HSC_identity", "Endo_identity", "log_library"], + "LAM_resolver": ["HSC_identity", "Myeloid_identity", "log_library"], + "retention_dominance": ["HSC_identity", "Endo_identity", "Myeloid_identity", "log_library"], + "AP1_control": ["HSC_identity", "log_library"], + "TGFb_integrator": ["HSC_identity", "Myeloid_identity", "log_library"], +} + +STAGE_ORDER = ["F0", "F1", "F2", "F3a", "F3b", "F4"] +GROUP_ORDER = ["early", "intermediate", "late"] +COLORS = { + "HSC_retention": "#C7472E", + "Endo_resolver": "#247BA0", + "LAM_resolver": "#4C956C", + "retention_dominance": "#7A1F3D", + "AP1_control": "#D88C1D", + "TGFb_integrator": "#6C5B7B", +} + + +def decode(values: np.ndarray) -> list[str]: + return [value.decode() if isinstance(value, bytes) else str(value) for value in values] + + +def bh(values: pd.Series) -> np.ndarray: + p = values.to_numpy(float) + order = np.argsort(p) + ranked = p[order] + q = ranked * len(p) / np.arange(1, len(p) + 1) + q = np.minimum.accumulate(q[::-1])[::-1] + result = np.empty_like(q) + result[order] = np.clip(q, 0, 1) + return result + + +def read_module_matrix(path: Path, genes: list[str]) -> tuple[list[str], list[str], np.ndarray, np.ndarray]: + with h5py.File(path) as handle: + matrix = handle["matrix"] + names = [name.upper() for name in decode(matrix["features/name"][:])] + barcodes = decode(matrix["barcodes"][:]) + shape = tuple(map(int, matrix["shape"][:])) + sparse = csc_matrix( + (matrix["data"][:], matrix["indices"][:], matrix["indptr"][:]), + shape=shape, + ) + lookup: dict[str, int] = {} + for index, name in enumerate(names): + lookup.setdefault(name, index) + present = [gene for gene in genes if gene in lookup] + selected = sparse[[lookup[gene] for gene in present], :].T.tocsr() + total = np.asarray(sparse.sum(axis=0)).ravel().astype(float) + normalized = selected.multiply((1e4 / np.maximum(total, 1))[:, None]).toarray() + normalized = np.log1p(normalized) + return barcodes, present, normalized, total + + +def explode_biopsy_map(mapping: pd.DataFrame) -> pd.DataFrame: + rows = [] + for record in mapping.to_dict("records"): + for component in str(record["component_members"]).split(","): + rows.append({**record, "component": component}) + return pd.DataFrame(rows).drop(columns="component_members") + + +def score_array( + array: str, + visium_root: Path, + component_spots: pd.DataFrame, + expanded_map: pd.DataFrame, +) -> tuple[pd.DataFrame, dict[str, list[str]], dict[str, int]]: + positions = pd.read_csv(visium_root / array / "spatial/tissue_positions.csv") + positions = positions.loc[positions["in_tissue"].eq(1)].copy() + component = component_spots.loc[component_spots["array"].eq(array), ["barcode", "component"]] + metadata = positions.merge(component, on="barcode", how="left") + metadata["array"] = array + metadata = metadata.merge( + expanded_map.loc[expanded_map["array"].eq(array)], + on=["array", "component"], + how="left", + validate="many_to_one", + ) + + labelled = metadata.dropna(subset=["biopsy_id"]) + missing = metadata["biopsy_id"].isna() + rescued = 0 + if missing.any() and len(labelled): + tree = cKDTree(labelled[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float)) + distance, nearest = tree.query(metadata.loc[missing, ["pxl_col_in_fullres", "pxl_row_in_fullres"]], k=1) + max_distance = np.median(tree.query(labelled[["pxl_col_in_fullres", "pxl_row_in_fullres"]], k=2)[0][:, 1]) * 5 + rescue_index = metadata.index[missing][distance <= max_distance] + source_index = labelled.index.to_numpy()[nearest[distance <= max_distance]] + transfer = ["component", "biopsy_id", "fibrosis_stage", "stage_numeric", "stage_group", "patient_cluster", "mapping_source"] + metadata.loc[rescue_index, transfer] = labelled.loc[source_index, transfer].to_numpy() + rescued = len(rescue_index) + + union = list(dict.fromkeys(gene for module in MODULES.values() for gene in module)) + barcodes, present, values, total = read_module_matrix( + visium_root / array / "filtered_feature_bc_matrix.h5", union + ) + expression = pd.DataFrame(values, index=barcodes, columns=present) + metadata = metadata.set_index("barcode").reindex(barcodes) + keep = metadata["biopsy_id"].notna().to_numpy() + metadata = metadata.loc[keep].copy() + expression = expression.loc[keep].copy() + total = total[keep] + metadata["log_library"] = np.log1p(total) + + mapped: dict[str, list[str]] = {} + for module, requested in MODULES.items(): + genes = [gene for gene in requested if gene in expression.columns] + genes = list(dict.fromkeys(genes)) + mapped[module] = genes + local = expression[genes].to_numpy(float) + mean = local.mean(axis=0) + sd = local.std(axis=0, ddof=1) + usable = sd > 1e-8 + z = (local[:, usable] - mean[usable]) / sd[usable] + metadata[module] = np.clip(z, -5, 5).mean(axis=1) + metadata["retention_dominance"] = metadata["HSC_retention"] - 0.5 * ( + metadata["Endo_resolver"] + metadata["LAM_resolver"] + ) + metadata["array"] = array + audit = { + "matrix_barcodes": len(barcodes), + "mapped_spots": len(metadata), + "unmapped_spots": len(barcodes) - len(metadata), + "rescued_small_fragment_spots": rescued, + } + return metadata.reset_index(names="barcode"), mapped, audit + + +def add_scar_proximity(data: pd.DataFrame, scar_quantile: float = 0.85) -> pd.DataFrame: + frames = [] + for _, local in data.groupby("biopsy_id", sort=False, observed=True): + local = local.copy() + threshold = local["ECM_scar"].quantile(scar_quantile) + local["scar_core"] = local["ECM_scar"].ge(threshold) + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + scar = coordinates[local["scar_core"].to_numpy()] + distance = cKDTree(scar).query(coordinates, k=1)[0] + proximity = -distance + local["scar_proximity"] = (proximity - proximity.mean()) / max(proximity.std(ddof=1), 1e-8) + local["scar_quantile"] = scar_quantile + frames.append(local) + return pd.concat(frames, ignore_index=True) + + +def pca_coordinates(data: pd.DataFrame) -> tuple[np.ndarray, np.ndarray]: + coordinates = data[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + centered = coordinates - coordinates.mean(axis=0) + _, _, vh = np.linalg.svd(centered, full_matrices=False) + rotated = centered @ vh.T + return rotated[:, 0], rotated[:, 1] + + +def make_blocks(data: pd.DataFrame, n_long: int, n_cross: int) -> pd.DataFrame: + local = data.copy() + long_axis, cross_axis = pca_coordinates(local) + local["long_bin"] = pd.qcut( + pd.Series(long_axis).rank(method="first"), n_long, labels=False + ).to_numpy() + local["cross_bin"] = pd.qcut( + pd.Series(cross_axis).rank(method="first"), n_cross, labels=False + ).to_numpy() + columns = ["scar_proximity", *OUTCOMES.keys(), "HSC_identity", "Endo_identity", "Myeloid_identity", "log_library"] + return local.groupby(["long_bin", "cross_bin"], observed=True)[columns].mean().reset_index() + + +def nearest_fill(grid: np.ndarray) -> np.ndarray: + filled = grid.copy() + missing = np.argwhere(~np.isfinite(filled)) + valid = np.argwhere(np.isfinite(filled)) + if len(missing): + tree = cKDTree(valid) + _, nearest = tree.query(missing, k=1) + filled[missing[:, 0], missing[:, 1]] = filled[valid[nearest, 0], valid[nearest, 1]] + return filled + + +def rectangular_transforms(n_long: int, n_cross: int) -> list[np.ndarray]: + grid = np.arange(n_long * n_cross).reshape(n_long, n_cross) + forms = [grid, np.flipud(grid), np.fliplr(grid), np.flipud(np.fliplr(grid))] + identity = tuple(grid.ravel()) + unique: dict[tuple[int, ...], np.ndarray] = {} + for form in forms: + for dx in range(n_long): + for dy in range(n_cross): + index = np.roll(np.roll(form, dx, axis=0), dy, axis=1).ravel() + key = tuple(map(int, index)) + if key != identity: + unique[key] = index + return list(unique.values()) + + +def toroidal_moran(grid: np.ndarray) -> float: + centered = grid - grid.mean() + lag = ( + np.roll(centered, 1, 0) + + np.roll(centered, -1, 0) + + np.roll(centered, 1, 1) + + np.roll(centered, -1, 1) + ) + denominator = np.sum(centered**2) + return float(np.sum(centered * lag) / (4 * denominator)) if denominator > 0 else np.nan + + +def fit_spatial_field_null( + blocks: pd.DataFrame, + outcome: str, + covariates: list[str], + n_long: int, + n_cross: int, +) -> dict[str, float]: + y = blocks[outcome].to_numpy(float) + nuisance = np.column_stack([np.ones(len(blocks))] + [blocks[name].to_numpy(float) for name in covariates]) + proximity = blocks["scar_proximity"].to_numpy(float) + full = np.column_stack([nuisance, proximity]) + coefficients, _, _, _ = np.linalg.lstsq(full, y, rcond=None) + residual = y - full @ coefficients + dof = max(len(y) - full.shape[1], 1) + sigma2 = float(residual @ residual / dof) + covariance = sigma2 * np.linalg.pinv(full.T @ full) + beta = float(coefficients[-1]) + se = float(np.sqrt(max(covariance[-1, -1], 0))) + + nuisance_coefficients = np.linalg.lstsq(nuisance, y, rcond=None)[0] + fitted = nuisance @ nuisance_coefficients + field = y - fitted + flat_position = blocks["long_bin"].to_numpy(int) * n_cross + blocks["cross_bin"].to_numpy(int) + grid = np.full((n_long, n_cross), np.nan) + grid.ravel()[flat_position] = field + grid = nearest_fill(grid) + transforms = rectangular_transforms(n_long, n_cross) + null = np.empty(len(transforms)) + moran = np.empty(len(transforms)) + for i, index in enumerate(transforms): + transformed = grid.ravel()[index][flat_position] + null[i] = np.linalg.lstsq(full, fitted + transformed, rcond=None)[0][-1] + moran[i] = toroidal_moran(grid.ravel()[index].reshape(n_long, n_cross)) + p = float((1 + np.sum(np.abs(null) >= abs(beta))) / (len(null) + 1)) + return { + "beta": beta, + "beta_se": se, + "beta_ci_low": beta - 1.96 * se, + "beta_ci_high": beta + 1.96 * se, + "spatial_field_p": p, + "n_transforms": len(transforms), + "n_blocks": len(blocks), + "grid_occupancy": len(blocks) / (n_long * n_cross), + "residual_moran": toroidal_moran(grid), + "permuted_moran_min": float(np.min(moran)), + "permuted_moran_max": float(np.max(moran)), + } + + +def fit_biopsies(data: pd.DataFrame) -> pd.DataFrame: + rows = [] + for biopsy, local in data.groupby("biopsy_id", sort=True, observed=True): + candidates = [(8, 4), (6, 3), (5, 3)] + blocks = None + chosen = None + for n_long, n_cross in candidates: + candidate = make_blocks(local, n_long, n_cross) + if len(candidate) >= max(12, int(0.55 * n_long * n_cross)): + blocks = candidate + chosen = (n_long, n_cross) + break + if blocks is None or chosen is None: + continue + metadata = local.iloc[0] + for outcome, covariates in OUTCOMES.items(): + result = fit_spatial_field_null(blocks, outcome, covariates, *chosen) + rows.append( + { + "biopsy_id": biopsy, + "patient_cluster": metadata["patient_cluster"], + "array": metadata["array"], + "fibrosis_stage": metadata["fibrosis_stage"], + "stage_numeric": metadata["stage_numeric"], + "stage_group": metadata["stage_group"], + "n_spots": len(local), + "outcome": outcome, + "covariates": ";".join(covariates), + "grid_long": chosen[0], + "grid_cross": chosen[1], + **result, + } + ) + results = pd.DataFrame(rows) + results["spatial_fdr_within_outcome"] = results.groupby("outcome", observed=True)["spatial_field_p"].transform(bh) + return results + + +def array_adjusted_trend(frame: pd.DataFrame, value: str, permutations: int = 9999) -> dict[str, float]: + patient = ( + frame.groupby(["patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], observed=True)[value] + .mean() + .reset_index() + ) + array_dummies = pd.get_dummies(patient["array"], drop_first=True, dtype=float) + x_reduced = np.column_stack([np.ones(len(patient)), array_dummies.to_numpy(float)]) + stage = patient["stage_numeric"].to_numpy(float) + x_full = np.column_stack([x_reduced, stage]) + y = patient[value].to_numpy(float) + fit = sm.OLS(y, x_full).fit(cov_type="HC3") + observed = float(fit.params[-1]) + + reduced_coef = np.linalg.lstsq(x_reduced, y, rcond=None)[0] + fitted = x_reduced @ reduced_coef + residual = y - fitted + rng = np.random.default_rng(20260711) + null = np.empty(permutations) + groups = [indices.to_numpy() for _, indices in patient.groupby("array", observed=True).groups.items()] + for i in range(permutations): + permuted = residual.copy() + for indices in groups: + permuted[indices] = rng.permutation(permuted[indices]) + null[i] = np.linalg.lstsq(x_full, fitted + permuted, rcond=None)[0][-1] + permutation_p = float((1 + np.sum(np.abs(null) >= abs(observed))) / (permutations + 1)) + rho, spearman_p = stats.spearmanr(patient["stage_numeric"], patient[value]) + return { + "n_patients": len(patient), + "stage_beta_array_adjusted": observed, + "stage_beta_hc3_se": float(fit.bse[-1]), + "stage_beta_hc3_p": float(fit.pvalues[-1]), + "stage_beta_within_array_permutation_p": permutation_p, + "spearman_rho": float(rho), + "spearman_p": float(spearman_p), + } + + +def trend_tables(coupling: pd.DataFrame, spot_scores: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame, pd.DataFrame]: + coupling_rows = [] + for outcome, local in coupling.groupby("outcome", observed=True): + coupling_rows.append({"outcome": outcome, **array_adjusted_trend(local, "beta")}) + coupling_trends = pd.DataFrame(coupling_rows) + + means = spot_scores.groupby( + ["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], observed=True + )[[*OUTCOMES.keys(), "ECM_scar"]].mean().reset_index() + mean_rows = [] + for outcome in [*OUTCOMES.keys(), "ECM_scar"]: + mean_rows.append({"outcome": outcome, **array_adjusted_trend(means, outcome)}) + return coupling_trends, pd.DataFrame(mean_rows), means + + +def choose_representatives(coupling: pd.DataFrame) -> list[str]: + dominance = coupling.loc[coupling["outcome"].eq("retention_dominance")].copy() + selected = [] + for group in GROUP_ORDER: + local = dominance.loc[dominance["stage_group"].eq(group)].copy() + target = local["beta"].median() + selected.append(local.loc[(local["beta"] - target).abs().idxmin(), "biopsy_id"]) + return selected + + +def plot_main(data: pd.DataFrame, coupling: pd.DataFrame, coupling_trends: pd.DataFrame, output: Path) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(15, 12), constrained_layout=True) + grid = fig.add_gridspec(3, 3, height_ratios=[1.0, 1.05, 1.0]) + representatives = choose_representatives(coupling) + stage_palette = {"early": "#4E79A7", "intermediate": "#E0A12B", "late": "#A23B3B"} + + for column, biopsy in enumerate(representatives): + ax = fig.add_subplot(grid[0, column]) + local = data.loc[data["biopsy_id"].eq(biopsy)] + scatter = ax.scatter( + local["pxl_col_in_fullres"], + -local["pxl_row_in_fullres"], + c=local["retention_dominance"], + cmap="RdBu_r", + vmin=-2, + vmax=2, + s=8, + linewidths=0, + rasterized=True, + ) + row = local.iloc[0] + ax.set_title(f"{row['stage_group'].title()} | {row['fibrosis_stage']} | {biopsy}", fontweight="bold") + ax.set_aspect("equal") + ax.set_axis_off() + if column == 0: + ax.text(-0.12, 1.05, "A", transform=ax.transAxes, fontsize=15, fontweight="bold") + colorbar = fig.colorbar(scatter, ax=[fig.axes[0], fig.axes[1], fig.axes[2]], shrink=0.72, pad=0.01) + colorbar.set_label("Retention dominance score") + + ax = fig.add_subplot(grid[1, :2]) + selected_outcomes = ["HSC_retention", "Endo_resolver", "LAM_resolver", "retention_dominance"] + plot = coupling.loc[coupling["outcome"].isin(selected_outcomes)].copy() + plot["stage_group"] = pd.Categorical(plot["stage_group"], GROUP_ORDER, ordered=True) + sns.boxplot( + data=plot, + x="stage_group", + y="beta", + hue="outcome", + hue_order=selected_outcomes, + palette=COLORS, + showfliers=False, + width=0.72, + ax=ax, + ) + sns.stripplot( + data=plot, + x="stage_group", + y="beta", + hue="outcome", + hue_order=selected_outcomes, + dodge=True, + palette=COLORS, + size=2.7, + alpha=0.65, + linewidth=0, + legend=False, + ax=ax, + ) + ax.axhline(0, color="#666666", lw=0.8) + ax.set_xlabel("") + ax.set_ylabel("Scar-proximity coupling beta") + ax.set_title("B Fibrosis stage shifts the scar-coupled control balance", loc="left", fontweight="bold") + ax.legend(frameon=False, ncol=2, fontsize=8) + + ax = fig.add_subplot(grid[1, 2]) + dominance = coupling.loc[coupling["outcome"].eq("retention_dominance")].copy() + model = sm.OLS(dominance["beta"], sm.add_constant(dominance["stage_numeric"].astype(float))).fit() + line_x = np.linspace(0, 4, 100) + prediction = model.get_prediction(sm.add_constant(line_x)).summary_frame() + ax.plot(line_x, prediction["mean"], color=COLORS["retention_dominance"], lw=2) + ax.fill_between( + line_x, + prediction["mean_ci_lower"].to_numpy(float), + prediction["mean_ci_upper"].to_numpy(float), + color=COLORS["retention_dominance"], + alpha=0.15, + linewidth=0, + ) + offsets = {"F3a": -0.11, "F3b": 0.11} + rng = np.random.default_rng(20260711) + point_x = dominance["stage_numeric"].astype(float).to_numpy(copy=True) + point_x += dominance["fibrosis_stage"].astype(str).map(offsets).fillna(0).to_numpy(float) + point_x += rng.uniform(-0.035, 0.035, len(dominance)) + ax.scatter( + point_x, + dominance["beta"], + c=dominance["stage_group"].astype(str).map(stage_palette), + s=27, + linewidths=0, + alpha=0.9, + ) + trend = coupling_trends.set_index("outcome").loc["retention_dominance"] + ax.text( + 0.03, + 0.97, + f"array-adjusted beta={trend['stage_beta_array_adjusted']:.3f}\npermutation P={trend['stage_beta_within_array_permutation_p']:.3g}", + transform=ax.transAxes, + ha="left", + va="top", + fontsize=8, + ) + ax.axhline(0, color="#777777", lw=0.8) + ax.set_xticks([0, 1, 2, 3, 4], ["F0", "F1", "F2", "F3a / F3b", "F4"]) + ax.set_xlabel("Fibrosis stage") + ax.set_ylabel("Retention-dominance coupling") + ax.set_title("C Closing resolver window", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[2, :2]) + heat = coupling.pivot(index="biopsy_id", columns="outcome", values="beta") + annotation = coupling.drop_duplicates("biopsy_id").set_index("biopsy_id") + order = annotation.sort_values(["stage_numeric", "array"]).index + columns = ["HSC_retention", "Endo_resolver", "LAM_resolver", "retention_dominance", "AP1_control", "TGFb_integrator"] + heat = heat.loc[order, columns] + sns.heatmap(heat.T, cmap="vlag", center=0, robust=True, xticklabels=False, cbar_kws={"label": "Coupling beta"}, ax=ax) + boundaries = np.where(np.diff(annotation.loc[order, "stage_numeric"].to_numpy()) != 0)[0] + 1 + for boundary in boundaries: + ax.axvline(boundary, color="white", lw=1.5) + ax.set_xlabel("33 biopsies ordered by fibrosis stage") + ax.set_ylabel("") + ax.set_title("D Coordinated spatial control architecture", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[2, 2]) + pplot = coupling.loc[coupling["outcome"].isin(selected_outcomes)].copy() + summary = pplot.groupby(["stage_group", "outcome"], observed=True)["spatial_field_p"].apply(lambda x: (x < 0.05).mean()).reset_index(name="fraction") + summary["stage_group"] = pd.Categorical(summary["stage_group"], GROUP_ORDER, ordered=True) + sns.barplot(data=summary, x="stage_group", y="fraction", hue="outcome", hue_order=selected_outcomes, palette=COLORS, ax=ax) + ax.set_ylim(0, 1) + ax.set_xlabel("") + ax.set_ylabel("Fraction spatial-null P < 0.05") + ax.set_title("E Autocorrelation-preserving support", loc="left", fontweight="bold") + ax.legend(frameon=False, fontsize=7) + + for axis in fig.axes: + if hasattr(axis, "spines"): + axis.spines[["top", "right"]].set_visible(False) + fig.suptitle( + "Human MASLD progression shifts the scar niche from resolution toward stellate-cell retention", + fontsize=16, + fontweight="bold", + ) + fig.savefig(output.with_suffix(".png"), dpi=350, bbox_inches="tight", facecolor="white") + fig.savefig(output.with_suffix(".pdf"), bbox_inches="tight", facecolor="white") + plt.close(fig) + + +def main() -> None: + parser = argparse.ArgumentParser() + parser.add_argument("--visium-root", type=Path, required=True) + parser.add_argument("--component-map", type=Path, required=True) + parser.add_argument("--biopsy-map", type=Path, required=True) + parser.add_argument("--results-dir", type=Path, required=True) + parser.add_argument("--figures-dir", type=Path, required=True) + args = parser.parse_args() + args.results_dir.mkdir(parents=True, exist_ok=True) + args.figures_dir.mkdir(parents=True, exist_ok=True) + + mapping = pd.read_csv(args.biopsy_map, sep="\t") + mapping["fibrosis_stage"] = pd.Categorical(mapping["fibrosis_stage"], STAGE_ORDER, ordered=True) + mapping["stage_group"] = pd.Categorical(mapping["stage_group"], GROUP_ORDER, ordered=True) + expanded = explode_biopsy_map(mapping) + component_spots = pd.read_parquet(args.component_map) + frames = [] + audits = [] + module_mapping: dict[str, set[str]] = {name: set() for name in MODULES} + for array in mapping["array"].drop_duplicates(): + scores, mapped, audit = score_array(array, args.visium_root, component_spots, expanded) + frames.append(scores) + audits.append({"array": array, **audit}) + for module, genes in mapped.items(): + module_mapping[module].update(genes) + scored = pd.concat(frames, ignore_index=True) + data = add_scar_proximity(scored, 0.85) + coupling = fit_biopsies(data) + coupling_trends, mean_trends, biopsy_means = trend_tables(coupling, data) + + sensitivity_frames = [] + sensitivity_trends = [] + for scar_quantile in [0.80, 0.85, 0.90]: + local_data = data if scar_quantile == 0.85 else add_scar_proximity(scored, scar_quantile) + local_coupling = coupling if scar_quantile == 0.85 else fit_biopsies(local_data) + local_coupling = local_coupling.copy() + local_coupling["scar_quantile"] = scar_quantile + local_trends, _, _ = trend_tables(local_coupling, local_data) + local_trends["scar_quantile"] = scar_quantile + sensitivity_frames.append(local_coupling) + sensitivity_trends.append(local_trends) + + data.to_parquet(args.results_dir / "UQ_Visium_spot_module_scores.parquet", index=False) + coupling.to_csv(args.results_dir / "UQ_Visium_biopsy_spatial_coupling.tsv", sep="\t", index=False) + coupling_trends.to_csv(args.results_dir / "UQ_Visium_coupling_stage_trends.tsv", sep="\t", index=False) + pd.concat(sensitivity_frames, ignore_index=True).to_csv( + args.results_dir / "UQ_Visium_scar_threshold_sensitivity_coupling.tsv", sep="\t", index=False + ) + pd.concat(sensitivity_trends, ignore_index=True).to_csv( + args.results_dir / "UQ_Visium_scar_threshold_sensitivity_trends.tsv", sep="\t", index=False + ) + mean_trends.to_csv(args.results_dir / "UQ_Visium_module_mean_stage_trends.tsv", sep="\t", index=False) + biopsy_means.to_csv(args.results_dir / "UQ_Visium_biopsy_module_means.tsv", sep="\t", index=False) + pd.DataFrame(audits).to_csv(args.results_dir / "UQ_Visium_mapping_audit.tsv", sep="\t", index=False) + (args.results_dir / "UQ_Visium_module_gene_mapping.json").write_text( + json.dumps({name: sorted(genes) for name, genes in module_mapping.items()}, indent=2) + "\n" + ) + plot_main(data, coupling, coupling_trends, args.figures_dir / "Figure_UQ_MASLD_resolver_window_validation") + print("\nCOUPLING STAGE TRENDS\n", coupling_trends.to_string(index=False)) + print("\nMODULE-MEAN STAGE TRENDS\n", mean_trends.to_string(index=False)) + print("\nMAPPING AUDIT\n", pd.DataFrame(audits).to_string(index=False)) + + +if __name__ == "__main__": + main() diff --git a/code/public_mechanism/mouse_resolver_lock_trajectory.py b/code/public_mechanism/mouse_resolver_lock_trajectory.py new file mode 100644 index 0000000..6461abc --- /dev/null +++ b/code/public_mechanism/mouse_resolver_lock_trajectory.py @@ -0,0 +1,176 @@ +#!/usr/bin/env python3 +"""Project replicated and cross-etiology mouse withdrawal data into resolver-lock space.""" + +from __future__ import annotations + +import argparse +import itertools +import json +from pathlib import Path + +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +import seaborn as sns + + +REPO_ROOT=Path(__file__).resolve().parents[2] +COUNTS=REPO_ROOT/"data/mouse_pseudobulk_derived/pseudobulk_counts.tsv.gz" +META=REPO_ROOT/"data/mouse_pseudobulk_derived/pseudobulk_metadata.tsv" +POOLED=REPO_ROOT/"data/mouse_pseudobulk_derived/state_module_trajectories.tsv" +OUTPUT=REPO_ROOT/"results/S13_mouse_resolver_retention_trajectory" +COLORS={"control":"#2A9D8F","fibrosis":"#C43D55","regression":"#E5A93D"} + +MODULES={ + "HSC_retention":("HSC_Mesenchymal",["Itgb5","Gas7","Spon1","Svep1","Pdgfra","Lama2","Epha3","Dpysl3","Ltbp2","Efemp1","Serpine1"]), + "feedback_core":("HSC_Mesenchymal",["Serpine1","Spon1","Gas7","Ltbp2"]), + "TGF_latch":("HSC_Mesenchymal",["Tgfb1","Tgfbr1","Tgfbr2","Smad3","Smad7","Ctgf","Ccn2","Thbs1"]), + "antiproteolytic_brake":("HSC_Mesenchymal",["Serpine1","Timp1","Timp2","Thbs1"]), + "protease_potential":("Myeloid",["Plau","Plat","Mmp2","Mmp9","Mmp14"]), + "Endo_resolver":("Endothelial",["Wnt9b","Wnt7b","Vwf","Ace","Kdr","Esam","Emcn","Plvap","Klf2","Nr2f2"]), + "LAM_resolver":("Myeloid",["Trem2","Gpnmb","Lpl","Mmp14","Ctsb","Ctsd","Axl","Mertk"]), +} + + +def zscore(values: np.ndarray) -> np.ndarray: + return (values-values.mean())/max(values.std(ddof=1),1e-8) + + +def build_scores() -> tuple[pd.DataFrame,pd.DataFrame]: + counts=pd.read_csv(COUNTS,sep="\t",index_col=0) + meta=pd.read_csv(META,sep="\t") + audit=[]; score={} + for module,(cell_type,genes) in MODULES.items(): + local=meta.loc[meta.cell_type.eq(cell_type)].sort_values("sample") + columns=local.pseudobulk.tolist() + matrix=counts[columns] + library=matrix.sum(axis=0).to_numpy(float) + logcpm=np.log2((matrix.to_numpy(float)+.5)/(library[None,:]+1)*1e6) + expression=pd.DataFrame(logcpm,index=matrix.index,columns=local["sample"]) + present=list(dict.fromkeys(gene for gene in genes if gene in expression.index)) + gene_z=np.vstack([zscore(expression.loc[gene].to_numpy(float)) for gene in present]) + score[module]=gene_z.mean(axis=0) + audit.append({"module":module,"cell_type":cell_type,"requested":len(set(genes)),"present":len(present),"genes":";".join(present)}) + samples=meta[["sample","condition"]].drop_duplicates().sort_values("sample").reset_index(drop=True) + for module,values in score.items(): samples[module]=values + samples["clearance_inefficiency"]=zscore(samples.antiproteolytic_brake.to_numpy())-zscore(samples.protease_potential.to_numpy()) + lock_features=["HSC_retention","feedback_core","TGF_latch","clearance_inefficiency"] + resolver_features=["Endo_resolver","LAM_resolver"] + samples["lock_axis"]=np.mean([zscore(samples[name].to_numpy()) for name in lock_features],axis=0) + samples["resolver_axis"]=np.mean([zscore(samples[name].to_numpy()) for name in resolver_features],axis=0) + samples["control_imbalance"]=(samples.lock_axis-samples.resolver_axis)/np.sqrt(2) + return samples,pd.DataFrame(audit) + + +def exact_group_test(samples:pd.DataFrame,outcome:str) -> pd.DataFrame: + values=samples[outcome].to_numpy(float) + observed={} + means=samples.groupby("condition")[outcome].mean() + observed["progression"]=means.fibrosis-means.control + observed["withdrawal"]=means.regression-means.fibrosis + observed["residual"]=means.regression-means.control + null={name:[] for name in observed} + indices=set(range(9)) + for control in itertools.combinations(range(9),3): + remaining=indices-set(control) + for fibrosis in itertools.combinations(sorted(remaining),3): + regression=sorted(remaining-set(fibrosis)) + m0=values[list(control)].mean(); m1=values[list(fibrosis)].mean(); m2=values[regression].mean() + null["progression"].append(m1-m0); null["withdrawal"].append(m2-m1); null["residual"].append(m2-m0) + rows=[] + for contrast,effect in observed.items(): + distribution=np.asarray(null[contrast]) + rows.append({"outcome":outcome,"contrast":contrast,"effect":float(effect),"exact_two_sided_p":float((1+np.sum(np.abs(distribution)>=abs(effect)))/(len(distribution)+1)),"exact_directional_p":float((1+np.sum(distribution>=effect))/(len(distribution)+1)) if effect>=0 else float((1+np.sum(distribution<=effect))/(len(distribution)+1)),"n_assignments":len(distribution)}) + return pd.DataFrame(rows) + + +def geometry(samples:pd.DataFrame) -> dict: + centroids=samples.groupby("condition")[["resolver_axis","lock_axis"]].mean() + control=centroids.loc["control"].to_numpy(); fibrosis=centroids.loc["fibrosis"].to_numpy(); regression=centroids.loc["regression"].to_numpy() + progression=fibrosis-control; recovery=regression-fibrosis + cosine=float(np.dot(-progression,recovery)/(np.linalg.norm(progression)*np.linalg.norm(recovery))) + return { + "progression_vector":progression.tolist(),"withdrawal_vector":recovery.tolist(), + "return_cosine":cosine,"return_angle_degrees":float(np.degrees(np.arccos(np.clip(cosine,-1,1)))), + "residual_distance_ratio":float(np.linalg.norm(regression-control)/np.linalg.norm(fibrosis-control)), + "control_centroid":control.tolist(),"fibrosis_centroid":fibrosis.tolist(),"regression_centroid":regression.tolist(), + } + + +def pooled_trajectories() -> pd.DataFrame: + d=pd.read_csv(POOLED,sep="\t") + p=d.pivot_table(index=["sample","etiology","timepoint","week"],columns="module",values="mean").reset_index() + p["resolver_proxy"]=p[["Endo4_WNT_resolver","LAM_resolver"]].mean(axis=1) + p["lock_proxy"]=p["HSC_pathogenic_retention"] + for column in ["resolver_proxy","lock_proxy"]: + p[column]=zscore(p[column].to_numpy(float)) + return p + + +def plot(samples:pd.DataFrame,pooled:pd.DataFrame,geom:dict) -> None: + sns.set_theme(style="ticks",context="paper",font_scale=1.0) + fig=plt.figure(figsize=(14.5,10.5)) + grid=fig.add_gridspec(2,2,left=.07,right=.98,bottom=.07,top=.91,wspace=.30,hspace=.34) + ax=fig.add_subplot(grid[0,0]) + for condition,local in samples.groupby("condition",observed=True): ax.scatter(local.resolver_axis,local.lock_axis,s=58,color=COLORS[condition],label=condition,edgecolor="white",linewidth=.7) + cent=samples.groupby("condition")[["resolver_axis","lock_axis"]].mean() + for start,end in [("control","fibrosis"),("fibrosis","regression")]: ax.annotate("",xy=cent.loc[end],xytext=cent.loc[start],arrowprops=dict(arrowstyle="-|>",lw=2.3,color="#424A4E")) + ax.axline((0,0),slope=1,color="#7E898E",ls="--",lw=1) + ax.set(xlabel="Resolver capacity",ylabel="HSC lock load") + ax.set_title("A Replicated withdrawal follows a non-reciprocal return path",loc="left",fontweight="bold"); ax.legend(frameon=False) + + ax=fig.add_subplot(grid[0,1]) + long=samples.melt(id_vars=["sample","condition"],value_vars=["resolver_axis","lock_axis","control_imbalance"],var_name="axis",value_name="score") + sns.boxplot(data=long,x="condition",y="score",hue="axis",palette={"resolver_axis":"#3182A6","lock_axis":"#B83D4B","control_imbalance":"#765A89"},fliersize=0,ax=ax) + sns.stripplot(data=long,x="condition",y="score",hue="axis",dodge=True,palette={"resolver_axis":"#3182A6","lock_axis":"#B83D4B","control_imbalance":"#765A89"},size=4,ax=ax,legend=False) + ax.axhline(0,color="#777",lw=.8); ax.set(xlabel="",ylabel="Standardized control score") + ax.set_title("B Lock load remains displaced after injury withdrawal",loc="left",fontweight="bold"); ax.legend(frameon=False,ncol=3,fontsize=7) + + ax=fig.add_subplot(grid[1,0]); ax.set_axis_off(); ax.set_xlim(0,1); ax.set_ylim(0,1) + ax.text(.03,.90,"CONTROL",color=COLORS['control'],fontweight="bold",fontsize=12) + ax.annotate("",xy=(.48,.72),xytext=(.18,.82),arrowprops=dict(arrowstyle="-|>",lw=6,color=COLORS['fibrosis'])) + ax.text(.50,.70,"FIBROSIS",color=COLORS['fibrosis'],fontweight="bold",fontsize=12) + ax.annotate("",xy=(.73,.45),xytext=(.53,.66),arrowprops=dict(arrowstyle="-|>",lw=6,color=COLORS['regression'])) + ax.text(.75,.42,"REGRESSION",color="#A87513",fontweight="bold",fontsize=12) + ax.plot([.75,.12],[.35,.75],ls="--",color="#879198",lw=1.2) + ax.text(.53,.20,f"Return angle {geom['return_angle_degrees']:.1f}°\nResidual distance {geom['residual_distance_ratio']:.2f}× peak displacement",ha="center",fontsize=11,bbox=dict(boxstyle="round,pad=.45",fc="white",ec="#919BA0")) + ax.set_title("C Incomplete withdrawal displacement",loc="left",fontweight="bold") + + ax=fig.add_subplot(grid[1,1]) + baseline=pooled.loc[pooled.etiology.eq("Untreated")].iloc[0] + ax.scatter(baseline.resolver_proxy,baseline.lock_proxy,s=90,color="#626B70",marker="s",label="untreated") + for etiology,color in [("CCl4","#3C78A8"),("FAT_MASH","#B64554")]: + local=pooled.loc[pooled.etiology.eq(etiology)].sort_values("week") + ax.plot(local.resolver_proxy,local.lock_proxy,marker="o",lw=2.3,color=color,label=etiology) + for _,row in local.iterrows(): ax.text(row.resolver_proxy+.03,row.lock_proxy+.03,row.timepoint,fontsize=7,color=color) + ax.axline((0,0),slope=1,color="#7E898E",ls="--",lw=1) + ax.set(xlabel="Resolver proxy",ylabel="HSC-retention proxy") + ax.set_title("D Cross-etiology trajectories converge on late resolver loss",loc="left",fontweight="bold"); ax.legend(frameon=False) + for axis in fig.axes: + if axis.axison: axis.spines[["top","right"]].set_visible(False) + fig.suptitle("Mouse withdrawal trajectories connect temporal non-reciprocity to the human resolver–lock landscape",fontsize=16,fontweight="bold") + fig.savefig(OUTPUT/"Mouse_resolver_lock_trajectory.png",dpi=320,facecolor="white"); fig.savefig(OUTPUT/"Mouse_resolver_lock_trajectory.pdf",facecolor="white"); plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser=argparse.ArgumentParser(description=__doc__) + parser.add_argument("--counts",type=Path,default=COUNTS) + parser.add_argument("--metadata",type=Path,default=META) + parser.add_argument("--pooled-trajectories",type=Path,default=POOLED) + parser.add_argument("--output-dir",type=Path,default=OUTPUT) + return parser.parse_args() + + +def main(): + global COUNTS,META,POOLED,OUTPUT + args=parse_args() + COUNTS,META,POOLED,OUTPUT=args.counts,args.metadata,args.pooled_trajectories,args.output_dir + OUTPUT.mkdir(parents=True,exist_ok=True) + samples,audit=build_scores(); pooled=pooled_trajectories(); geom=geometry(samples) + tests=pd.concat([exact_group_test(samples,outcome) for outcome in ["resolver_axis","lock_axis","control_imbalance"]],ignore_index=True) + plot(samples,pooled,geom) + samples.to_csv(OUTPUT/"GSE295293_mouse_phase_scores.tsv",sep="\t",index=False); audit.to_csv(OUTPUT/"mouse_module_mapping.tsv",sep="\t",index=False); tests.to_csv(OUTPUT/"GSE295293_exact_phase_tests.tsv",sep="\t",index=False); pooled.to_csv(OUTPUT/"GSE305331_cross_etiology_phase_trajectories.tsv",sep="\t",index=False) + summary={"n_replicated_mice":len(samples),"geometry":geom,"tests":tests.to_dict(orient="records"),"claim":"Withdrawal follows a non-reciprocal trajectory with residual displacement in resolver-lock space."} + (OUTPUT/"mouse_phase_trajectory_summary.json").write_text(json.dumps(summary,indent=2,ensure_ascii=False)+"\n"); print(json.dumps(summary,indent=2,ensure_ascii=False)) + +if __name__=="__main__": main() diff --git a/code/public_mechanism/sequential_basin_switch_drugs.py b/code/public_mechanism/sequential_basin_switch_drugs.py new file mode 100644 index 0000000..8598522 --- /dev/null +++ b/code/public_mechanism/sequential_basin_switch_drugs.py @@ -0,0 +1,233 @@ +#!/usr/bin/env python3 +"""Rank phase-ordered LINCS pairs by predicted basin-switching advantage.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import matplotlib.pyplot as plt +from matplotlib.patches import FancyBboxPatch +import numpy as np +import pandas as pd +import seaborn as sns + + +REPO_ROOT = Path(__file__).resolve().parents[2] +INPUT = REPO_ROOT / "data/LINCS_derived/LINCS_name_collapsed_hard_gated.tsv" +OUTPUT = REPO_ROOT / "results/S12_order_aware_drug_nomination" + +FOCUS = ["ezetimibe", "verteporfin", "wz-4002", "psb-069", "pioglitazone", "pre-084"] +EARLY_COLOR = "#238B8D" +LATE_COLOR = "#C33F55" +ORDER_COLOR = "#75558F" + + +def percentile(values: pd.Series) -> pd.Series: + return values.rank(method="average", pct=True) + + +def pair_score(early: pd.Series, late: pd.Series, early_retention_weight: float = 0.5, resolver_weight: float = 0.5, penalty_weight: float = 1.5) -> float: + endo = early.median_endo_support + 0.5 * late.median_endo_support + macro = early.median_macro_support + 0.5 * late.median_macro_support + retention = late.median_retention_suppression + early_retention_weight * early.median_retention_suppression + penalty = penalty_weight * max(0.0, -min(endo, macro)) + return float(retention + resolver_weight * endo + resolver_weight * macro - penalty) + + +def build_pairs(compounds: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame, pd.DataFrame]: + eligible = compounds.loc[ + compounds.identity_resolved.fillna(False) + & compounds.n_signatures.ge(3) + & compounds.n_cell_lines.ge(2) + & ~compounds.duplicate_id_conflict.fillna(False) + ].copy() + eligible["mean_resolver"] = 0.5 * (eligible.median_endo_support + eligible.median_macro_support) + early = eligible.loc[ + eligible.median_resolver_floor.ge(0.10) + & eligible.mean_resolver.ge(0.20) + & eligible.median_retention_suppression.ge(-0.10) + ].copy() + late = eligible.loc[ + eligible.median_retention_suppression.ge(0.20) + & eligible.q25_retention_suppression.ge(0.10) + & eligible.median_resolver_floor.ge(-0.15) + ].copy() + rows = [] + for _, e in early.iterrows(): + for _, l in late.iterrows(): + if e.pert_iname_norm == l.pert_iname_norm: + continue + forward = pair_score(e, l) + reverse = pair_score(l, e) + rows.append( + { + "early_compound": e.pert_iname_norm, + "late_compound": l.pert_iname_norm, + "forward_score": forward, + "reverse_score": reverse, + "order_advantage": forward - reverse, + "early_mean_resolver": e.mean_resolver, + "early_resolver_floor": e.median_resolver_floor, + "early_retention": e.median_retention_suppression, + "late_retention": l.median_retention_suppression, + "late_q25_retention": l.q25_retention_suppression, + "late_resolver_floor": l.median_resolver_floor, + "early_tier": e.translation_tier, + "late_tier": l.translation_tier, + "both_named": bool(e.named_identity and l.named_identity), + "both_hard_gate": bool(e.computational_hard_gate and l.computational_hard_gate), + } + ) + pairs = pd.DataFrame(rows) + pairs["forward_percentile"] = percentile(pairs.forward_score) + pairs["order_percentile"] = percentile(pairs.order_advantage) + pairs["basin_switch_index"] = 0.65 * pairs.forward_percentile + 0.35 * pairs.order_percentile + pairs["basin_switch_rank"] = pairs.basin_switch_index.rank(ascending=False, method="min").astype(int) + return eligible, early, pairs.sort_values("basin_switch_index", ascending=False) + + +def weight_sensitivity(early: pd.DataFrame, late: pd.DataFrame) -> pd.DataFrame: + rows = [] + for er in [0.25, 0.5, 0.75]: + for rw in [0.35, 0.5, 0.65]: + for pw in [1.0, 1.5, 2.0]: + local = [] + for _, e in early.iterrows(): + for _, l in late.iterrows(): + if e.pert_iname_norm == l.pert_iname_norm: + continue + forward = pair_score(e, l, er, rw, pw) + reverse = pair_score(l, e, er, rw, pw) + local.append((e.pert_iname_norm, l.pert_iname_norm, forward, forward - reverse)) + frame = pd.DataFrame(local, columns=["early", "late", "forward", "advantage"]) + frame["index"] = 0.65 * percentile(frame.forward) + 0.35 * percentile(frame.advantage) + frame["rank"] = frame["index"].rank(ascending=False, method="min") + target = frame.loc[frame.early.eq("ezetimibe") & frame.late.eq("verteporfin")] + if len(target): + row = target.iloc[0] + rows.append( + { + "early_retention_weight": er, + "resolver_weight": rw, + "penalty_weight": pw, + "forward_score": row.forward, + "order_advantage": row.advantage, + "basin_switch_index": row["index"], + "rank": int(row["rank"]), + "n_pairs": len(frame), + } + ) + return pd.DataFrame(rows) + + +def plot_results(eligible: pd.DataFrame, pairs: pd.DataFrame) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(15.5, 11.5)) + grid = fig.add_gridspec(2, 2, left=.07, right=.98, bottom=.07, top=.91, wspace=.30, hspace=.34) + + ax = fig.add_subplot(grid[0, 0]) + ax.scatter(eligible.mean_resolver, eligible.median_retention_suppression, s=15, color="#C7CDD0", alpha=.55) + for name in FOCUS: + local = eligible.loc[eligible.pert_iname_norm.eq(name)] + if len(local): + row = local.iloc[0] + ax.scatter(row.mean_resolver, row.median_retention_suppression, s=70, color=EARLY_COLOR if name=="ezetimibe" else LATE_COLOR, edgecolor="white", linewidth=.8, zorder=3) + ax.text(row.mean_resolver+.012,row.median_retention_suppression+.008,name,fontsize=8) + ax.axvline(.20,color=EARLY_COLOR,ls="--",lw=1); ax.axhline(.20,color=LATE_COLOR,ls="--",lw=1) + ax.set(xlabel="Mean endothelial/macrophage resolver support",ylabel="HSC-retention suppression") + ax.set_title("A Early and late controllers occupy different Pareto sectors",loc="left",fontweight="bold") + + ax = fig.add_subplot(grid[0, 1]) + named = pairs.loc[pairs.both_named].head(12).sort_values("order_advantage") + labels = named.early_compound + " → " + named.late_compound + y = np.arange(len(named)) + for yi, (_, row) in enumerate(named.iterrows()): + ax.plot([row.reverse_score,row.forward_score],[yi,yi],color="#AAB2B6",lw=2) + ax.scatter(row.reverse_score,yi,color="#7A8790",s=34,zorder=3) + ax.scatter(row.forward_score,yi,color=ORDER_COLOR,s=42,zorder=3) + ax.set_yticks(y,labels); ax.set_xlabel("Ordered pair score") + ax.set_title("B Sequence creates a directional control advantage",loc="left",fontweight="bold") + ax.text(.98,.04,"grey: reverse purple: forward",transform=ax.transAxes,ha="right",fontsize=8) + + ax = fig.add_subplot(grid[1, 0]) + early_names = pairs.groupby("early_compound").basin_switch_index.max().nlargest(10).index + late_names = pairs.groupby("late_compound").basin_switch_index.max().nlargest(10).index + heat = pairs.loc[pairs.early_compound.isin(early_names)&pairs.late_compound.isin(late_names)].pivot(index="early_compound",columns="late_compound",values="order_advantage") + heat = heat.reindex(index=early_names,columns=late_names) + sns.heatmap(heat,cmap="PRGn",center=0,annot=True,fmt=".2f",annot_kws={"fontsize":6},cbar_kws={"label":"Order advantage","shrink":.72},ax=ax) + ax.set(xlabel="Late lock suppressor",ylabel="Early resolver primer") + ax.set_title("C Ordered-pair control matrix",loc="left",fontweight="bold") + + ax = fig.add_subplot(grid[1, 1]) + target = pairs.loc[pairs.early_compound.eq("ezetimibe")&pairs.late_compound.eq("verteporfin")].iloc[0] + ax.set_axis_off(); ax.set_xlim(0,168); ax.set_ylim(0,1) + def band(start, end, y, label, color): + patch=FancyBboxPatch((start,y),end-start,.13,boxstyle="round,pad=0.012,rounding_size=2",fc=color,ec=color,lw=1) + ax.add_patch(patch); ax.text((start+end)/2,y+.065,label,ha="center",va="center",color="white",fontweight="bold",fontsize=8) + band(0,24,.75,"EZETIMIBE\nresolver priming",EARLY_COLOR) + band(24,72,.75,"VERTEPORFIN\nYAP/TEAD switching",LATE_COLOR) + band(72,168,.75,"PIOGLITAZONE\nstate stabilization","#C18C24") + ax.annotate("",xy=(24,.815),xytext=(20,.815),arrowprops=dict(arrowstyle="-|>",color="#454C50",lw=1.5)) + ax.annotate("",xy=(72,.815),xytext=(68,.815),arrowprops=dict(arrowstyle="-|>",color="#454C50",lw=1.5)) + rows=[ + (.57,"Endothelium","WNT9B · KLF2 · EMCN","#3182A6",0,28), + (.42,"Macrophage","TREM2 · GPNMB · MMP14","#4D8A63",0,34), + (.27,"HSC lock","YAP/TEAD · SERPINE1 · SPON1","#B83D4B",24,78), + (.12,"Durability","PPARγ quiescence · re-challenge threshold","#9B7421",72,168), + ] + for y,label,readout,color,start,end in rows: + ax.text(0,y,label,ha="left",va="center",fontweight="bold",color=color) + ax.plot([start,end],[y,y],color=color,lw=5,solid_capstyle="round",alpha=.78) + ax.text(min(end+3,166),y,readout,ha="left" if end<150 else "right",va="center",fontsize=7.5,color="#3F474B") + ax.text(166,.96,f"E → V {target.forward_score:.3f}\nV → E {target.reverse_score:.3f}\nΔorder {target.order_advantage:.3f}",ha="right",va="top",bbox=dict(boxstyle="round,pad=.35",fc="white",ec="#8D969C")) + ax.text(84,.02,"Equal cumulative exposure; compare simultaneous, forward and reverse order",ha="center",fontsize=8,color="#626C72") + ax.set_title("D Prime–switch–stabilize experiment",loc="left",fontweight="bold") + + for axis in fig.axes: + if axis.axison: + axis.spines[["top","right"]].set_visible(False) + fig.suptitle("Phase-ordered perturbations are predicted to switch the resolver–lock basin",fontsize=16,fontweight="bold") + fig.savefig(OUTPUT/"LINCS_sequential_basin_switch.png",dpi=320,facecolor="white") + fig.savefig(OUTPUT/"LINCS_sequential_basin_switch.pdf",facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser=argparse.ArgumentParser(description=__doc__) + parser.add_argument("--input",type=Path,default=INPUT) + parser.add_argument("--output-dir",type=Path,default=OUTPUT) + return parser.parse_args() + + +def main() -> None: + global INPUT,OUTPUT + args=parse_args() + INPUT,OUTPUT=args.input,args.output_dir + OUTPUT.mkdir(parents=True,exist_ok=True) + compounds=pd.read_csv(INPUT,sep="\t") + eligible,early,pairs=build_pairs(compounds) + late_names=pairs.late_compound.unique() + late=eligible.loc[eligible.pert_iname_norm.isin(late_names)].copy() + sensitivity=weight_sensitivity(early,late) + plot_results(eligible,pairs) + pairs.to_csv(OUTPUT/"LINCS_ordered_basin_switch_pairs.tsv",sep="\t",index=False) + sensitivity.to_csv(OUTPUT/"ezetimibe_verteporfin_weight_sensitivity.tsv",sep="\t",index=False) + target=pairs.loc[pairs.early_compound.eq("ezetimibe")&pairs.late_compound.eq("verteporfin")].iloc[0] + summary={ + "n_eligible_compounds":int(len(eligible)), + "n_early_primers":int(len(early)), + "n_late_suppressors":int(len(late)), + "n_ordered_pairs":int(len(pairs)), + "lead_pair":"ezetimibe -> verteporfin", + "lead_pair_metrics":target.to_dict(), + "weight_sensitivity":{"median_rank":float(sensitivity['rank'].median()),"best_rank":int(sensitivity['rank'].min()),"worst_rank":int(sensitivity['rank'].max()),"n_schemes":int(len(sensitivity))}, + "claim":"A prime-then-switch hypothesis with a strong computed direction advantage; designed for direct equal-exposure order testing.", + } + (OUTPUT/"sequential_basin_switch_summary.json").write_text(json.dumps(summary,indent=2,ensure_ascii=False)+"\n") + print(json.dumps(summary,indent=2,ensure_ascii=False)) + + +if __name__=="__main__": + main() diff --git a/code/public_mechanism/spatial_domain_wall_resolver_window.py b/code/public_mechanism/spatial_domain_wall_resolver_window.py new file mode 100644 index 0000000..1ddd10f --- /dev/null +++ b/code/public_mechanism/spatial_domain_wall_resolver_window.py @@ -0,0 +1,496 @@ +#!/usr/bin/env python3 +"""Test whether locked spatial domains coalesce as the resolver window closes.""" + +from __future__ import annotations + +import argparse +from collections import deque +import json +from pathlib import Path + +import matplotlib.pyplot as plt +from matplotlib.colors import LinearSegmentedColormap +import numpy as np +import pandas as pd +import seaborn as sns +from scipy.spatial import cKDTree +from scipy.stats import spearmanr, wilcoxon +import statsmodels.formula.api as smf + + +REPO_ROOT = Path(__file__).resolve().parents[2] +INPUT = REPO_ROOT / "data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spot_states.parquet" +OUTPUT = REPO_ROOT / "results/S14_spatial_retention_domains" +SEED = 20260712 + +COLORS = { + "Endothelial resolver": "#2D8FB3", + "Macrophage resolver": "#58A47A", + "Protease activation": "#7D71B3", + "Antiproteolytic brake": "#D18F24", + "HSC retention": "#C43D55", + "TGF-beta integrator": "#8D5A4A", + "Structural ECM": "#3F4548", +} + +FEATURES = { + "Endothelial resolver": "adj_Endo_resolver", + "Macrophage resolver": "adj_LAM_resolver", + "Protease activation": "adj_protease_activation_potential", + "Antiproteolytic brake": "adj_antiproteolytic_brake", + "HSC retention": "adj_HSC_retention", + "TGF-beta integrator": "adj_TGFb_integrator", + "Structural ECM": "structural_ECM_scar", +} + + +def bh(values: pd.Series) -> np.ndarray: + p = values.to_numpy(float) + order = np.argsort(p) + ranked = p[order] * len(p) / np.arange(1, len(p) + 1) + ranked = np.minimum.accumulate(ranked[::-1])[::-1] + result = np.empty_like(ranked) + result[order] = np.clip(ranked, 0, 1) + return result + + +def graph_for_biopsy(local: pd.DataFrame) -> tuple[list[list[int]], list[tuple[int, int]]]: + xy = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + tree = cKDTree(xy) + nearest = tree.query(xy, k=2)[0][:, 1] + radius = float(np.median(nearest) * 1.25) + pairs = sorted(tree.query_pairs(radius)) + adjacency = [[] for _ in range(len(local))] + for i, j in pairs: + adjacency[i].append(j) + adjacency[j].append(i) + return adjacency, pairs + + +def signed_domain_distance(state: np.ndarray, adjacency: list[list[int]]) -> tuple[np.ndarray, np.ndarray]: + distance = np.full(len(state), 10_000, dtype=int) + boundary = np.zeros(len(state), dtype=bool) + queue: deque[int] = deque() + for i, neighbors in enumerate(adjacency): + if any(state[j] != state[i] for j in neighbors): + distance[i] = 1 + boundary[i] = True + queue.append(i) + while queue: + i = queue.popleft() + for j in adjacency[i]: + if state[j] == state[i] and distance[j] > distance[i] + 1: + distance[j] = distance[i] + 1 + queue.append(j) + finite = distance < 10_000 + if not finite.all(): + distance[~finite] = 7 + signed = np.minimum(distance, 7) * np.where(state, 1, -1) + return signed, boundary + + +def largest_component(state: np.ndarray, adjacency: list[list[int]]) -> int: + seen: set[int] = set() + sizes: list[int] = [] + for start in np.flatnonzero(state): + if int(start) in seen: + continue + stack = [int(start)] + seen.add(int(start)) + size = 0 + while stack: + node = stack.pop() + size += 1 + for neighbor in adjacency[node]: + if state[neighbor] and neighbor not in seen: + seen.add(neighbor) + stack.append(neighbor) + sizes.append(size) + return max(sizes, default=0) + + +def build_front_data(spots: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + annotated = [] + topology = [] + for biopsy_id, source in spots.groupby("biopsy_id", sort=False): + local = source.reset_index(drop=True).copy() + adjacency, pairs = graph_for_biopsy(local) + state = local.p_locked.to_numpy(float) >= 0.5 + signed, boundary = signed_domain_distance(state, adjacency) + local["locked_binary"] = state + local["signed_domain_distance"] = signed + local["domain_boundary"] = boundary + annotated.append(local) + + locked_n = int(state.sum()) + largest = largest_component(state, adjacency) + cross_edges = int(sum(state[i] != state[j] for i, j in pairs)) + topology.append( + { + "biopsy_id": biopsy_id, + "array": local["array"].iloc[0], + "patient_cluster": local.patient_cluster.iloc[0], + "stage_numeric": float(local.stage_numeric.iloc[0]), + "stage_group": local.stage_group.iloc[0], + "n_spots": int(len(local)), + "locked_fraction": locked_n / len(local), + "largest_locked_domain_fraction": largest / len(local), + "locked_domain_coherence": largest / max(locked_n, 1), + "interface_edge_fraction": cross_edges / max(len(pairs), 1), + "n_graph_edges": int(len(pairs)), + } + ) + return pd.concat(annotated, ignore_index=True), pd.DataFrame(topology) + + +def biopsy_profiles(front: pd.DataFrame) -> pd.DataFrame: + distances = [-4, -3, -2, -1, 1, 2, 3, 4] + rows = [] + for (biopsy_id, distance), local in front.loc[ + front.signed_domain_distance.isin(distances) + ].groupby(["biopsy_id", "signed_domain_distance"], observed=True): + row = { + "biopsy_id": biopsy_id, + "patient_cluster": local.patient_cluster.iloc[0], + "stage_numeric": float(local.stage_numeric.iloc[0]), + "distance": int(distance), + "n_spots": int(len(local)), + } + for label, feature in FEATURES.items(): + row[label] = float(local[feature].mean()) + resolver = local[[ + FEATURES["Endothelial resolver"], + FEATURES["Macrophage resolver"], + FEATURES["Protease activation"], + ]].mean(axis=1) + lock = local[[ + FEATURES["Antiproteolytic brake"], + FEATURES["HSC retention"], + FEATURES["TGF-beta integrator"], + ]].mean(axis=1) + row["resolver_advantage"] = float((resolver - lock).mean()) + rows.append(row) + return pd.DataFrame(rows) + + +def clustered_bootstrap(values: pd.DataFrame, column: str, n_boot: int = 4000) -> tuple[float, float]: + rng = np.random.default_rng(SEED) + cluster_stats = values.groupby("patient_cluster")[column].agg(["sum", "count"]) + sums = cluster_stats["sum"].to_numpy(float) + counts = cluster_stats["count"].to_numpy(float) + sampled = rng.integers(0, len(cluster_stats), size=(n_boot, len(cluster_stats))) + estimates = sums[sampled].sum(axis=1) / counts[sampled].sum(axis=1) + return tuple(np.quantile(estimates, [0.025, 0.975])) + + +def boundary_effects(front: pd.DataFrame) -> pd.DataFrame: + rows = [] + for biopsy_id, local in front.groupby("biopsy_id", sort=False): + resolved = local.signed_domain_distance.isin([-2, -1]) + locked = local.signed_domain_distance.isin([1, 2]) + if not resolved.any() or not locked.any(): + continue + base = { + "biopsy_id": biopsy_id, + "patient_cluster": local.patient_cluster.iloc[0], + "stage_numeric": float(local.stage_numeric.iloc[0]), + } + for label, feature in FEATURES.items(): + rows.append( + { + **base, + "module": label, + "locked_minus_resolved": float(local.loc[locked, feature].mean() - local.loc[resolved, feature].mean()), + } + ) + effects = pd.DataFrame(rows) + summaries = [] + for module, local in effects.groupby("module", sort=False): + statistic, p_value = wilcoxon(local.locked_minus_resolved, alternative="two-sided") + low, high = clustered_bootstrap(local, "locked_minus_resolved") + summaries.append( + { + "module": module, + "n_biopsies": int(local.biopsy_id.nunique()), + "mean_shift": float(local.locked_minus_resolved.mean()), + "median_shift": float(local.locked_minus_resolved.median()), + "bootstrap_ci_low": float(low), + "bootstrap_ci_high": float(high), + "wilcoxon_statistic": float(statistic), + "p_value": float(p_value), + } + ) + summary = pd.DataFrame(summaries) + summary["fdr"] = bh(summary.p_value) + return effects.merge(summary[["module", "fdr"]], on="module", how="left"), summary + + +def topology_trends(topology: pd.DataFrame, n_perm: int = 10_000) -> pd.DataFrame: + rng = np.random.default_rng(SEED) + metrics = [ + "locked_fraction", + "largest_locked_domain_fraction", + "locked_domain_coherence", + "interface_edge_fraction", + ] + rows = [] + groups = [np.asarray(list(index), dtype=int) for index in topology.groupby("array").groups.values()] + stage = topology.stage_numeric.to_numpy(float) + stage_centered = stage.copy() + for index in groups: + stage_centered[index] -= stage_centered[index].mean() + for metric in metrics: + fit = smf.ols(f"{metric} ~ stage_numeric + C(array)", data=topology).fit(cov_type="HC3") + observed = float(fit.params["stage_numeric"]) + outcome_centered = topology[metric].to_numpy(float).copy() + for index in groups: + outcome_centered[index] -= outcome_centered[index].mean() + null = np.empty(n_perm) + for index in range(n_perm): + permuted = stage_centered.copy() + for positions in groups: + permuted[positions] = rng.permutation(permuted[positions]) + null[index] = np.dot(permuted, outcome_centered) / np.dot(permuted, permuted) + permutation_p = (1 + np.sum(np.abs(null) >= abs(observed))) / (n_perm + 1) + rho, spearman_p = spearmanr(topology.stage_numeric, topology[metric]) + rows.append( + { + "metric": metric, + "stage_beta_array_adjusted": observed, + "hc3_p_value": float(fit.pvalues["stage_numeric"]), + "within_array_permutation_p": float(permutation_p), + "spearman_rho": float(rho), + "spearman_p_value": float(spearman_p), + } + ) + trends = pd.DataFrame(rows) + trends["permutation_fdr"] = bh(trends.within_array_permutation_p) + return trends + + +def threshold_sensitivity(spots: pd.DataFrame) -> pd.DataFrame: + rows = [] + for threshold in [0.40, 0.50, 0.60, 0.67]: + metrics = [] + for biopsy_id, source in spots.groupby("biopsy_id", sort=False): + local = source.reset_index(drop=True) + adjacency, pairs = graph_for_biopsy(local) + state = local.p_locked.to_numpy(float) >= threshold + largest = largest_component(state, adjacency) + metrics.append( + { + "biopsy_id": biopsy_id, + "array": local["array"].iloc[0], + "stage_numeric": float(local.stage_numeric.iloc[0]), + "largest_locked_domain_fraction": largest / len(local), + "interface_edge_fraction": sum(state[i] != state[j] for i, j in pairs) / max(len(pairs), 1), + } + ) + local_metrics = pd.DataFrame(metrics) + for metric in ["largest_locked_domain_fraction", "interface_edge_fraction"]: + fit = smf.ols(f"{metric} ~ stage_numeric + C(array)", data=local_metrics).fit(cov_type="HC3") + rows.append( + { + "p_locked_threshold": threshold, + "metric": metric, + "stage_beta_array_adjusted": float(fit.params["stage_numeric"]), + "hc3_p_value": float(fit.pvalues["stage_numeric"]), + } + ) + result = pd.DataFrame(rows) + result["hc3_fdr"] = bh(result.hc3_p_value) + return result + + +def profile_summary(profiles: pd.DataFrame) -> pd.DataFrame: + rows = [] + columns = [*FEATURES.keys(), "resolver_advantage"] + for distance, local in profiles.groupby("distance"): + for column in columns: + low, high = clustered_bootstrap(local, column, n_boot=2500) + rows.append( + { + "distance": int(distance), + "module": column, + "mean": float(local[column].mean()), + "ci_low": float(low), + "ci_high": float(high), + "n_biopsies": int(local.biopsy_id.nunique()), + } + ) + return pd.DataFrame(rows) + + +def plot_results( + front: pd.DataFrame, + topology: pd.DataFrame, + profile_stats: pd.DataFrame, + effect_summary: pd.DataFrame, + trends: pd.DataFrame, +) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(17.5, 11.5), facecolor="white") + grid = fig.add_gridspec(2, 3, left=.09, right=.985, bottom=.065, top=.91, wspace=.34, hspace=.37) + + mixed = front.groupby("biopsy_id").agg(n=("barcode", "size"), locked=("locked_binary", "mean")) + representative = (mixed.n * 4 * mixed.locked * (1 - mixed.locked)).idxmax() + local = front.loc[front.biopsy_id.eq(representative)].copy() + ax = fig.add_subplot(grid[0, 0]) + cmap = LinearSegmentedColormap.from_list("basin", ["#2A9D8F", "#E5B84B", "#C43D55"]) + ax.scatter( + local.pxl_col_in_fullres, + -local.pxl_row_in_fullres, + c=local.p_locked, + cmap=cmap, + vmin=0, + vmax=1, + s=16, + linewidth=0, + ) + wall = local.loc[local.domain_boundary] + ax.scatter( + wall.pxl_col_in_fullres, + -wall.pxl_row_in_fullres, + facecolors="none", + edgecolors="#222222", + linewidth=.45, + s=27, + ) + ax.set_aspect("equal") + ax.set_axis_off() + ax.set_title(f"A A resolved-to-locked domain wall ({representative})", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[0, 1]) + modules = ["Endothelial resolver", "Macrophage resolver", "Antiproteolytic brake", "HSC retention", "Structural ECM"] + for module in modules: + plot = profile_stats.loc[profile_stats.module.eq(module) & profile_stats.n_biopsies.ge(8)].sort_values("distance") + ax.plot(plot.distance, plot["mean"], marker="o", ms=3.5, lw=1.8, color=COLORS[module], label=module) + ax.fill_between(plot.distance, plot.ci_low, plot.ci_high, color=COLORS[module], alpha=.12, linewidth=0) + ax.axvline(0, color="#59636A", ls="--", lw=1) + ax.set(xlabel="Signed graph distance from separatrix", ylabel="Array-adjusted module activity") + ax.set_title("B State programs align across the separatrix", loc="left", fontweight="bold") + ax.legend(frameon=False, fontsize=7, ncol=2, loc="upper left") + + ax = fig.add_subplot(grid[0, 2]) + advantage = profile_stats.loc[ + profile_stats.module.eq("resolver_advantage") & profile_stats.n_biopsies.ge(8) + ].sort_values("distance") + ax.plot(advantage.distance, advantage["mean"], color="#3A6670", marker="o", lw=2.3) + ax.fill_between(advantage.distance, advantage.ci_low, advantage.ci_high, color="#3A6670", alpha=.18, linewidth=0) + ax.axhline(0, color="#444", lw=.8) + ax.axvline(0, color="#59636A", ls="--", lw=1) + ax.fill_between([-4, 0], -1.2, 1.2, color="#2A9D8F", alpha=.06) + ax.fill_between([0, 4], -1.2, 1.2, color="#C43D55", alpha=.06) + ax.text(-3.8, .95, "resolver window open", color="#287D72", fontsize=8) + ax.text(.2, .95, "lock exceeds resolver", color="#A52E46", fontsize=8) + ax.set(xlabel="Signed graph distance from separatrix", ylabel="Resolver advantage") + ax.set_ylim(-1.15, 1.1) + ax.set_title("C The resolver window closes inside the locked domain", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 0]) + order = effect_summary.sort_values("mean_shift").reset_index(drop=True) + y = np.arange(len(order)) + for index, row in order.iterrows(): + ax.plot([row.bootstrap_ci_low, row.bootstrap_ci_high], [index, index], color=COLORS[row.module], lw=2) + ax.scatter(row.mean_shift, index, color=COLORS[row.module], s=42, edgecolor="white", linewidth=.5, zorder=3) + ax.text(row.bootstrap_ci_high + .012, index, f"q={row.fdr:.2g}", va="center", fontsize=7, color="#4D5559") + labels = [row.module for row in order.itertuples()] + ax.set_yticks(y, labels) + ax.axvline(0, color="#555", lw=.8) + ax.set_xlim(-.03, .58) + ax.set_xlabel("Locked minus resolved boundary activity") + ax.set_title("D State alignment across 33 biopsies", loc="left", fontweight="bold") + + stage_palette = {0: "#87B7A7", 1: "#68A7A0", 2: "#D8AD55", 3: "#C36C64", 4: "#A93651"} + ax = fig.add_subplot(grid[1, 1]) + rng = np.random.default_rng(SEED) + for stage, local_stage in topology.groupby("stage_numeric"): + x = stage + rng.normal(0, .045, len(local_stage)) + ax.scatter(x, local_stage.largest_locked_domain_fraction, color=stage_palette[int(stage)], s=38, edgecolor="white", linewidth=.5) + sns.regplot(data=topology, x="stage_numeric", y="largest_locked_domain_fraction", scatter=False, color="#5A3740", ci=95, ax=ax) + trend = trends.set_index("metric").loc["largest_locked_domain_fraction"] + ax.text(.03, .96, f"array-adjusted beta={trend.stage_beta_array_adjusted:.3f}\npermutation q={trend.permutation_fdr:.3g}", transform=ax.transAxes, va="top", fontsize=8) + ax.set(xlabel="Fibrosis stage", ylabel="Largest locked domain / biopsy") + ax.set_title("E Locked islands coalesce into a dominant domain", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 2]) + for stage, local_stage in topology.groupby("stage_numeric"): + x = stage + rng.normal(0, .045, len(local_stage)) + ax.scatter(x, local_stage.interface_edge_fraction, color=stage_palette[int(stage)], s=38, edgecolor="white", linewidth=.5) + sns.regplot(data=topology, x="stage_numeric", y="interface_edge_fraction", scatter=False, color="#3A6670", ci=95, ax=ax) + trend = trends.set_index("metric").loc["interface_edge_fraction"] + ax.text(.03, .96, f"array-adjusted beta={trend.stage_beta_array_adjusted:.3f}\npermutation q={trend.permutation_fdr:.3g}", transform=ax.transAxes, va="top", fontsize=8) + ax.set(xlabel="Fibrosis stage", ylabel="Resolved-locked interface / graph edges") + ax.set_title("F Interface compression marks spatial lock-in", loc="left", fontweight="bold") + + for axis in fig.axes: + if axis.axison: + axis.spines[["top", "right"]].set_visible(False) + fig.suptitle("Locked domains coalesce as the spatial resolver window closes", fontsize=17, fontweight="bold") + fig.savefig(OUTPUT / "Spatial_domain_wall_resolver_window.png", dpi=320, facecolor="white") + fig.savefig(OUTPUT / "Spatial_domain_wall_resolver_window.pdf", facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--input", type=Path, default=INPUT) + parser.add_argument("--output-dir", type=Path, default=OUTPUT) + return parser.parse_args() + + +def main() -> None: + global INPUT, OUTPUT + args = parse_args() + INPUT, OUTPUT = args.input, args.output_dir + OUTPUT.mkdir(parents=True, exist_ok=True) + spots = pd.read_parquet(INPUT) + front, topology = build_front_data(spots) + profiles = biopsy_profiles(front) + profile_stats = profile_summary(profiles) + effects, effect_summary = boundary_effects(front) + trends = topology_trends(topology) + sensitivity = threshold_sensitivity(spots) + plot_results(front, topology, profile_stats, effect_summary, trends) + + front[[ + "barcode", "array", "biopsy_id", "patient_cluster", "stage_numeric", "p_locked", + "locked_binary", "signed_domain_distance", "domain_boundary", + ]].to_parquet(OUTPUT / "domain_wall_spot_annotations.parquet", index=False) + topology.to_csv(OUTPUT / "spatial_domain_topology.tsv", sep="\t", index=False) + profiles.to_csv(OUTPUT / "domain_wall_biopsy_profiles.tsv", sep="\t", index=False) + profile_stats.to_csv(OUTPUT / "domain_wall_profile_summary.tsv", sep="\t", index=False) + effects.to_csv(OUTPUT / "domain_wall_boundary_effects_by_biopsy.tsv", sep="\t", index=False) + effect_summary.to_csv(OUTPUT / "domain_wall_boundary_effect_summary.tsv", sep="\t", index=False) + trends.to_csv(OUTPUT / "spatial_domain_stage_trends.tsv", sep="\t", index=False) + sensitivity.to_csv(OUTPUT / "spatial_domain_threshold_sensitivity.tsv", sep="\t", index=False) + + trend_index = trends.set_index("metric") + summary = { + "n_spots": int(len(front)), + "n_biopsies": int(front.biopsy_id.nunique()), + "n_patients": int(front.patient_cluster.nunique()), + "boundary_definition": "p_locked >= 0.5; signed shortest-path distance to nearest opposite-basin spot", + "largest_domain_stage_beta": float(trend_index.loc["largest_locked_domain_fraction", "stage_beta_array_adjusted"]), + "largest_domain_permutation_fdr": float(trend_index.loc["largest_locked_domain_fraction", "permutation_fdr"]), + "interface_stage_beta": float(trend_index.loc["interface_edge_fraction", "stage_beta_array_adjusted"]), + "interface_permutation_fdr": float(trend_index.loc["interface_edge_fraction", "permutation_fdr"]), + "threshold_sensitivity": { + "thresholds": sensitivity.p_locked_threshold.unique().tolist(), + "largest_domain_beta_range": [ + float(sensitivity.loc[sensitivity.metric.eq("largest_locked_domain_fraction"), "stage_beta_array_adjusted"].min()), + float(sensitivity.loc[sensitivity.metric.eq("largest_locked_domain_fraction"), "stage_beta_array_adjusted"].max()), + ], + "interface_beta_range": [ + float(sensitivity.loc[sensitivity.metric.eq("interface_edge_fraction"), "stage_beta_array_adjusted"].min()), + float(sensitivity.loc[sensitivity.metric.eq("interface_edge_fraction"), "stage_beta_array_adjusted"].max()), + ], + }, + "interpretation": "Fibrosis progression consolidates initially fragmented locked islands into a dominant spatial domain while compressing the resolved-locked interface; across that interface the resolver advantage changes sign as HSC retention and antiproteolytic control overtake resolver activity.", + } + (OUTPUT / "spatial_domain_wall_summary.json").write_text(json.dumps(summary, indent=2) + "\n") + print(json.dumps(summary, indent=2)) + + +if __name__ == "__main__": + main() diff --git a/code/public_mechanism/uq_phase_basin_control.py b/code/public_mechanism/uq_phase_basin_control.py new file mode 100644 index 0000000..9692d51 --- /dev/null +++ b/code/public_mechanism/uq_phase_basin_control.py @@ -0,0 +1,624 @@ +#!/usr/bin/env python3 +"""Learn resolver/lock state basins and test history-dependent locking in UQ Visium.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import diptest +import matplotlib.pyplot as plt +from matplotlib.patches import Ellipse +import numpy as np +import pandas as pd +import seaborn as sns +from scipy import stats +from scipy.spatial import cKDTree +from sklearn.decomposition import PCA +from sklearn.mixture import GaussianMixture +from sklearn.preprocessing import StandardScaler +import statsmodels.api as sm +from statsmodels.nonparametric.smoothers_lowess import lowess + + +REPO_ROOT = Path(__file__).resolve().parents[2] +INPUT = REPO_ROOT / "data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_spot_scores.parquet" +OUTPUT = REPO_ROOT / "results/S11_UQ_static_component_control" +RNG = np.random.default_rng(20260712) +STAGE_ORDER = ["early", "intermediate", "late"] +STAGE_COLORS = {"early": "#3182A6", "intermediate": "#E3A12F", "late": "#B83D4B"} +STATE_COLORS = {"resolved": "#2A9D8F", "transition": "#E9B949", "locked": "#C43D55"} + +LOCK_FEATURES = { + "HSC_retention": ["HSC_identity", "log_library"], + "feedback_core": ["HSC_identity", "log_library"], + "clearance_inefficiency": ["HSC_identity", "Myeloid_identity", "log_library"], + "TGFb_integrator": ["HSC_identity", "Myeloid_identity", "log_library"], +} +RESOLVER_FEATURES = { + "Endo_resolver": ["Endo_identity", "HSC_identity", "log_library"], + "LAM_resolver": ["Myeloid_identity", "HSC_identity", "log_library"], +} +AUX_FEATURES = { + "antiproteolytic_brake": ["HSC_identity", "Myeloid_identity", "log_library"], + "protease_activation_potential": ["HSC_identity", "Myeloid_identity", "log_library"], +} + + +def bh(values: pd.Series) -> np.ndarray: + p = values.to_numpy(float) + order = np.argsort(p) + q = p[order] * len(p) / np.arange(1, len(p) + 1) + q = np.minimum.accumulate(q[::-1])[::-1] + result = np.empty_like(q) + result[order] = np.clip(q, 0, 1) + return result + + +def array_design(data: pd.DataFrame, covariates: list[str]) -> np.ndarray: + array = pd.get_dummies(data["array"], drop_first=True, dtype=float) + return np.column_stack( + [np.ones(len(data))] + + [data[name].to_numpy(float) for name in covariates] + + [array.to_numpy(float)] + ) + + +def residualize_features(data: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + data = data.copy() + audit = [] + for family, definitions in [("lock", LOCK_FEATURES), ("resolver", RESOLVER_FEATURES), ("aux", AUX_FEATURES)]: + for feature, covariates in definitions.items(): + x = array_design(data, covariates) + y = data[feature].to_numpy(float) + residual = y - x @ np.linalg.lstsq(x, y, rcond=None)[0] + residual = (residual - residual.mean()) / max(residual.std(ddof=1), 1e-8) + data[f"adj_{feature}"] = residual + audit.append( + { + "family": family, + "feature": feature, + "covariates": ";".join(covariates) + ";array_fixed_effects", + "residual_sd": float(residual.std(ddof=1)), + "raw_residual_r": float(np.corrcoef(y, residual)[0, 1]), + } + ) + + loadings = [] + for family, features in [ + ("lock", list(LOCK_FEATURES)), + ("resolver", list(RESOLVER_FEATURES)), + ]: + columns = [f"adj_{feature}" for feature in features] + matrix = StandardScaler().fit_transform(data[columns]) + model = PCA(n_components=1, random_state=20260712) + axis = model.fit_transform(matrix).ravel() + orientation = 1 if model.components_[0].sum() >= 0 else -1 + axis *= orientation + data[f"{family}_axis"] = (axis - axis.mean()) / axis.std(ddof=1) + for feature, weight in zip(features, model.components_[0] * orientation): + loadings.append( + { + "axis": family, + "feature": feature, + "loading": float(weight), + "explained_variance": float(model.explained_variance_ratio_[0]), + } + ) + data["control_imbalance"] = (data["lock_axis"] - data["resolver_axis"]) / np.sqrt(2) + data["lock_mechanistic_equal"] = data[ + ["adj_HSC_retention", "adj_feedback_core", "adj_antiproteolytic_brake", "adj_TGFb_integrator"] + ].mean(axis=1) + data["resolver_mechanistic_equal"] = data[ + ["adj_Endo_resolver", "adj_LAM_resolver", "adj_protease_activation_potential"] + ].mean(axis=1) + data["lock_compact_equal"] = data[ + ["adj_HSC_retention", "adj_feedback_core", "adj_clearance_inefficiency"] + ].mean(axis=1) + data["resolver_compact_equal"] = data[["adj_Endo_resolver", "adj_LAM_resolver"]].mean(axis=1) + for column in [ + "lock_mechanistic_equal", "resolver_mechanistic_equal", + "lock_compact_equal", "resolver_compact_equal", + ]: + data[column] = (data[column] - data[column].mean()) / max(data[column].std(ddof=1), 1e-8) + return data, pd.concat([pd.DataFrame(audit), pd.DataFrame(loadings)], ignore_index=True, sort=False) + + +def spatial_blocks(data: pd.DataFrame) -> pd.DataFrame: + rows = [] + numeric = [ + "lock_axis", "resolver_axis", "control_imbalance", "ECM_scar", "scar_proximity", + "HSC_retention", "clearance_inefficiency", "feedback_core", "TGFb_integrator", + "lock_mechanistic_equal", "resolver_mechanistic_equal", + "lock_compact_equal", "resolver_compact_equal", + ] + for biopsy, local in data.groupby("biopsy_id", sort=True, observed=True): + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + centered = coordinates - coordinates.mean(axis=0) + _, _, vh = np.linalg.svd(centered, full_matrices=False) + rotated = centered @ vh.T + local = local.copy() + local["long_bin"] = pd.qcut(pd.Series(rotated[:, 0]).rank(method="first"), 6, labels=False).to_numpy() + local["cross_bin"] = pd.qcut(pd.Series(rotated[:, 1]).rank(method="first"), 3, labels=False).to_numpy() + block = local.groupby(["long_bin", "cross_bin"], observed=True)[numeric].mean().reset_index() + meta = local.iloc[0] + block["biopsy_id"] = biopsy + for name in ["patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"]: + block[name] = meta[name] + block["n_spots_biopsy"] = len(local) + rows.append(block) + return pd.concat(rows, ignore_index=True) + + +def fit_basins(blocks: pd.DataFrame, data: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame, GaussianMixture, dict[int, str]]: + x = blocks[["resolver_axis", "lock_axis"]].to_numpy(float) + bic_rows = [] + models = {} + for k in range(1, 6): + model = GaussianMixture(n_components=k, covariance_type="full", n_init=50, random_state=20260712) + model.fit(x) + models[k] = model + bic_rows.append({"n_components": k, "bic": float(model.bic(x)), "aic": float(model.aic(x))}) + bic = pd.DataFrame(bic_rows) + + model = models[2] + component_imbalance = model.means_[:, 1] - model.means_[:, 0] + ordered = np.argsort(component_imbalance) + labels = {int(ordered[0]): "resolved", int(ordered[1]): "locked"} + probabilities = model.predict_proba(data[["resolver_axis", "lock_axis"]].to_numpy(float)) + components = model.predict(data[["resolver_axis", "lock_axis"]].to_numpy(float)) + data = data.copy() + data["basin_component"] = components + for component, state in labels.items(): + data[f"p_{state}"] = probabilities[:, component] + data["p_transition"] = 4 * data["p_resolved"] * data["p_locked"] + data["basin_state"] = np.where( + data["p_locked"].ge(0.67), + "locked", + np.where(data["p_resolved"].ge(0.67), "resolved", "transition"), + ) + data["basin_escape_margin"] = data["p_locked"] - data["p_resolved"] + return data, bic, model, labels + + +def dip_and_bootstrap(blocks: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + rows = [] + for group, local in [("all", blocks), *blocks.groupby("stage_group", observed=True)]: + values = local["control_imbalance"].to_numpy(float) + dip, p = diptest.diptest(values, boot_pval=True, n_boot=5000, seed=20260712) + rows.append({"stage_group": group, "n_blocks": len(values), "dip": float(dip), "dip_p": float(p)}) + + patient_ids = blocks["patient_cluster"].unique() + boot_rows = [] + for iteration in range(300): + selected = RNG.choice(patient_ids, len(patient_ids), replace=True) + sample = pd.concat( + [blocks.loc[blocks.patient_cluster.eq(patient)].assign(bootstrap_copy=i) for i, patient in enumerate(selected)], + ignore_index=True, + ) + x = sample[["resolver_axis", "lock_axis"]].to_numpy(float) + bics = [] + for k in range(1, 5): + model = GaussianMixture(n_components=k, covariance_type="full", n_init=5, random_state=iteration + 1) + model.fit(x) + bics.append(model.bic(x)) + boot_rows.append( + { + "iteration": iteration, + "best_k": int(np.argmin(bics) + 1), + "bic_gain_1_to_3": float(bics[0] - bics[2]), + "multibasin_supported": bool(min(bics[1:]) < bics[0] - 10), + } + ) + return pd.DataFrame(rows), pd.DataFrame(boot_rows) + + +def leave_one_patient_out( + blocks: pd.DataFrame, + full_model: GaussianMixture, + full_labels: dict[int, str], +) -> pd.DataFrame: + x = blocks[["resolver_axis", "lock_axis"]].to_numpy(float) + full_locked_component = next(component for component, state in full_labels.items() if state == "locked") + full_probability = full_model.predict_proba(x)[:, full_locked_component] + rows = [] + for patient in blocks.patient_cluster.unique(): + test = blocks.patient_cluster.eq(patient).to_numpy() + train = ~test + model = GaussianMixture(n_components=2, covariance_type="full", n_init=30, random_state=20260712) + model.fit(x[train]) + imbalance = model.means_[:, 1] - model.means_[:, 0] + locked_component = int(np.argmax(imbalance)) + predicted = model.predict_proba(x[test])[:, locked_component] + expected = full_probability[test] + correlation = float(np.corrcoef(predicted, expected)[0, 1]) if len(predicted) > 1 else np.nan + rows.append( + { + "patient_cluster": patient, + "n_blocks": int(test.sum()), + "posterior_r": correlation, + "posterior_mae": float(np.mean(np.abs(predicted - expected))), + "basin_agreement": float(np.mean((predicted >= 0.5) == (expected >= 0.5))), + } + ) + return pd.DataFrame(rows) + + +def state_fractions(data: pd.DataFrame) -> pd.DataFrame: + fractions = ( + data.groupby( + ["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group", "basin_state"], + observed=True, + ).size().rename("n_spots").reset_index() + ) + fractions["fraction"] = fractions["n_spots"] / fractions.groupby("biopsy_id", observed=True)["n_spots"].transform("sum") + return fractions + + +def array_adjusted_trend(frame: pd.DataFrame, value: str, permutations: int = 9999) -> dict[str, float]: + patient = frame.groupby( + ["patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], observed=True + )[value].mean().reset_index() + dummies = pd.get_dummies(patient["array"], drop_first=True, dtype=float) + x0 = np.column_stack([np.ones(len(patient)), dummies.to_numpy(float)]) + stage = patient["stage_numeric"].to_numpy(float) + x = np.column_stack([x0, stage]) + y = patient[value].to_numpy(float) + fit = sm.OLS(y, x).fit(cov_type="HC3") + observed = float(fit.params[-1]) + reduced = x0 @ np.linalg.lstsq(x0, y, rcond=None)[0] + residual = y - reduced + groups = [np.asarray(indices, int) for _, indices in patient.groupby("array", observed=True).indices.items()] + null = np.empty(permutations) + for i in range(permutations): + permuted = residual.copy() + for indices in groups: + permuted[indices] = RNG.permutation(permuted[indices]) + null[i] = np.linalg.lstsq(x, reduced + permuted, rcond=None)[0][-1] + return { + "n_patients": len(patient), + "stage_beta": observed, + "hc3_se": float(fit.bse[-1]), + "hc3_p": float(fit.pvalues[-1]), + "within_array_permutation_p": float((1 + np.sum(np.abs(null) >= abs(observed))) / (permutations + 1)), + "spearman_rho": float(stats.spearmanr(patient.stage_numeric, patient[value]).statistic), + } + + +def fraction_trends(fractions: pd.DataFrame) -> pd.DataFrame: + rows = [] + for state in ["resolved", "transition", "locked"]: + local = fractions.loc[fractions.basin_state.eq(state)] + rows.append({"basin_state": state, **array_adjusted_trend(local, "fraction")}) + result = pd.DataFrame(rows) + result["permutation_fdr"] = bh(result["within_array_permutation_p"]) + return result + + +def axis_sensitivity(blocks: pd.DataFrame) -> pd.DataFrame: + definitions = { + "pca_primary": ("resolver_axis", "lock_axis"), + "mechanistic_equal": ("resolver_mechanistic_equal", "lock_mechanistic_equal"), + "compact_equal": ("resolver_compact_equal", "lock_compact_equal"), + } + rows = [] + for name, (resolver, lock) in definitions.items(): + x = blocks[[resolver, lock]].to_numpy(float) + one = GaussianMixture(n_components=1, covariance_type="full", n_init=30, random_state=20260712).fit(x) + two = GaussianMixture(n_components=2, covariance_type="full", n_init=50, random_state=20260712).fit(x) + imbalance = two.means_[:, 1] - two.means_[:, 0] + locked_component = int(np.argmax(imbalance)) + probability = two.predict_proba(x)[:, locked_component] + local = blocks[["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"]].copy() + local["locked"] = probability >= 0.67 + fraction = local.groupby( + ["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], + observed=True, + ).locked.mean().reset_index(name="fraction") + trend = array_adjusted_trend(fraction, "fraction", permutations=4999) + rows.append( + { + "axis_definition": name, + "resolver_column": resolver, + "lock_column": lock, + "bic_gain_one_to_two": float(one.bic(x) - two.bic(x)), + **trend, + } + ) + result = pd.DataFrame(rows) + result["permutation_fdr"] = bh(result.within_array_permutation_p) + return result + + +def memory_test(blocks: pd.DataFrame, data: pd.DataFrame, permutations: int = 9999) -> tuple[pd.DataFrame, pd.DataFrame]: + probabilities = data.groupby(["biopsy_id", "long_bin", "cross_bin"], observed=True)["p_locked"].mean().reset_index() + model_data = blocks.merge(probabilities, on=["biopsy_id", "long_bin", "cross_bin"], validate="one_to_one") + p = np.clip(model_data.p_locked.to_numpy(float), 1e-4, 1 - 1e-4) + y = np.log(p / (1 - p)) + ecm = model_data.ECM_scar.to_numpy(float) + resolver = model_data.resolver_axis.to_numpy(float) + stage = model_data.stage_numeric.to_numpy(float) + arrays = pd.get_dummies(model_data.array, drop_first=True, dtype=float).to_numpy(float) + x0 = np.column_stack([np.ones(len(model_data)), ecm, ecm**2, resolver, arrays]) + x = np.column_stack([x0, stage]) + groups = pd.Categorical(model_data.patient_cluster).codes + fit = sm.OLS(y, x).fit(cov_type="cluster", cov_kwds={"groups": groups}) + observed = float(fit.params[-1]) + + reduced = x0 @ np.linalg.lstsq(x0, y, rcond=None)[0] + residual = y - reduced + patient_meta = model_data[["patient_cluster", "array", "stage_numeric"]].drop_duplicates("patient_cluster") + null = np.empty(permutations) + for i in range(permutations): + permuted_stage = {} + for _, local in patient_meta.groupby("array", observed=True): + values = RNG.permutation(local.stage_numeric.to_numpy(float)) + permuted_stage.update(dict(zip(local.patient_cluster, values))) + stage_perm = model_data.patient_cluster.map(permuted_stage).to_numpy(float) + xp = np.column_stack([x0, stage_perm]) + null[i] = np.linalg.lstsq(xp, reduced + residual, rcond=None)[0][-1] + result = pd.DataFrame( + [{ + "test": "matched_ECM_resolver_stage_memory", + "n_blocks": len(model_data), + "n_patients": model_data.patient_cluster.nunique(), + "stage_beta_logit_locked": observed, + "cluster_se": float(fit.bse[-1]), + "cluster_p": float(fit.pvalues[-1]), + "within_array_patient_permutation_p": float((1 + np.sum(np.abs(null) >= abs(observed))) / (permutations + 1)), + }] + ) + return model_data, result + + +def front_profiles(data: pd.DataFrame) -> pd.DataFrame: + local = data.copy() + local["front_bin"] = pd.cut(local.scar_proximity, bins=np.linspace(-3.0, 1.0, 17), include_lowest=True) + patient = local.groupby( + ["patient_cluster", "stage_group", "front_bin"], observed=True + )[["p_locked", "p_transition", "p_resolved", "control_imbalance"]].mean().reset_index() + patient["front_mid"] = patient.front_bin.map(lambda value: float(value.mid)).astype(float) + rows = [] + for (group, midpoint), frame in patient.groupby(["stage_group", "front_mid"], observed=True): + values = frame.p_locked.to_numpy(float) + boot = np.array([np.mean(RNG.choice(values, len(values), replace=True)) for _ in range(2000)]) + rows.append( + { + "stage_group": group, + "front_mid": midpoint, + "n_patients": len(values), + "mean_p_locked": float(np.mean(values)), + "ci_low": float(np.quantile(boot, 0.025)), + "ci_high": float(np.quantile(boot, 0.975)), + } + ) + return pd.DataFrame(rows) + + +def adjacency(data: pd.DataFrame) -> pd.DataFrame: + rows = [] + for biopsy, local in data.groupby("biopsy_id", observed=True): + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + tree = cKDTree(coordinates) + distance, index = tree.query(coordinates, k=7) + cutoff = np.median(distance[:, 1]) * 1.25 + states = local.basin_state.to_numpy(str) + counts = {(a, b): 0 for a in STATE_COLORS for b in STATE_COLORS} + for i in range(len(local)): + for d, j in zip(distance[i, 1:], index[i, 1:]): + if d <= cutoff and i < j: + a, b = sorted([states[i], states[j]]) + counts[(a, b)] = counts.get((a, b), 0) + 1 + total = max(sum(counts.values()), 1) + meta = local.iloc[0] + for (a, b), count in counts.items(): + if count: + rows.append( + { + "biopsy_id": biopsy, + "patient_cluster": meta.patient_cluster, + "stage_group": meta.stage_group, + "state_a": a, + "state_b": b, + "edge_count": count, + "edge_fraction": count / total, + } + ) + return pd.DataFrame(rows) + + +def add_gmm_ellipses(ax, model: GaussianMixture, labels: dict[int, str]) -> None: + for component in range(model.n_components): + covariance = model.covariances_[component] + values, vectors = np.linalg.eigh(covariance) + order = values.argsort()[::-1] + values, vectors = values[order], vectors[:, order] + angle = np.degrees(np.arctan2(vectors[1, 0], vectors[0, 0])) + state = labels[component] + for scale, alpha in [(2.0, 0.9), (3.2, 0.35)]: + ellipse = Ellipse( + model.means_[component], + width=scale * np.sqrt(values[0]), + height=scale * np.sqrt(values[1]), + angle=angle, + fill=False, + lw=1.7 if scale == 2.0 else 0.9, + alpha=alpha, + edgecolor=STATE_COLORS[state], + ) + ax.add_patch(ellipse) + ax.text(*model.means_[component], state.upper(), color=STATE_COLORS[state], fontweight="bold", ha="center") + + +def plot_figure( + data: pd.DataFrame, + blocks: pd.DataFrame, + bic: pd.DataFrame, + model: GaussianMixture, + labels: dict[int, str], + fractions: pd.DataFrame, + model_data: pd.DataFrame, + fronts: pd.DataFrame, + memory: pd.DataFrame, +) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(16, 14), constrained_layout=False) + grid = fig.add_gridspec(3, 2, height_ratios=[1.05, 1, 1.05]) + + ax = fig.add_subplot(grid[0, 0]) + hb = ax.hexbin(blocks.resolver_axis, blocks.lock_axis, gridsize=42, mincnt=1, cmap="Greys", bins="log", alpha=0.88) + add_gmm_ellipses(ax, model, labels) + ax.axline((0, 0), slope=1, color="#6C757D", ls="--", lw=1) + ax.set(xlabel="Resolver capacity axis", ylabel="HSC lock-load axis") + ax.set_title("A Two basins separated by a transition boundary", loc="left", fontweight="bold") + fig.colorbar(hb, ax=ax, label="Spatial-block density", shrink=0.72) + + ax = fig.add_subplot(grid[0, 1]) + ax.plot(bic.n_components, bic.bic - bic.bic.min(), marker="o", color="#4E5D6C", lw=1.8) + ax.axhline(10, color="#B83D4B", ls="--", lw=1) + ax.set(xticks=bic.n_components, xlabel="Gaussian-mixture components", ylabel="BIC above optimum") + ax.set_title("B Multibasin structure is preferred", loc="left", fontweight="bold") + best = int(bic.loc[bic.bic.idxmin(), "n_components"]) + ax.text(.97,.92,f"Best K = {best}\nΔBIC(1→2) = {bic.loc[bic.n_components.eq(1),'bic'].iloc[0]-bic.loc[bic.n_components.eq(2),'bic'].iloc[0]:.1f}",transform=ax.transAxes,ha="right",va="top",bbox=dict(boxstyle="round,pad=.35",fc="white",ec="#88939B")) + + ax = fig.add_subplot(grid[1, 0]) + patient = fractions.groupby(["patient_cluster", "stage_numeric", "stage_group", "basin_state"], observed=True).fraction.mean().reset_index() + sns.boxplot(data=patient, x="stage_numeric", y="fraction", hue="basin_state", hue_order=["resolved","transition","locked"], palette=STATE_COLORS, fliersize=0, ax=ax) + sns.stripplot(data=patient, x="stage_numeric", y="fraction", hue="basin_state", hue_order=["resolved","transition","locked"], dodge=True, palette=STATE_COLORS, size=2.7, alpha=.65, ax=ax, legend=False) + ax.set(xlabel="Fibrosis stage", ylabel="Patient basin fraction") + ax.set_title("C Fibrosis stage redistributes spatial state occupancy", loc="left", fontweight="bold") + ax.legend(frameon=False, ncol=3, loc="upper left") + + ax = fig.add_subplot(grid[1, 1]) + for group in STAGE_ORDER: + local = model_data.loc[model_data.stage_group.eq(group)].sort_values("ECM_scar") + smooth = lowess(local.p_locked, local.ECM_scar, frac=.42, return_sorted=True) + ax.plot(smooth[:,0], smooth[:,1], color=STAGE_COLORS[group], lw=2.4, label=group) + ax.scatter(local.ECM_scar, local.p_locked, s=6, alpha=.10, color=STAGE_COLORS[group]) + ax.set(xlabel="Structural ECM load", ylabel="Locked-basin probability", ylim=(-.02,1.02)) + ax.set_title("D The separatrix generalizes across stages", loc="left", fontweight="bold") + ax.text(.98,.05,f"Matched ECM + resolver\nstage P = {memory.within_array_patient_permutation_p.iloc[0]:.3f}",transform=ax.transAxes,ha="right",va="bottom",bbox=dict(boxstyle="round,pad=.3",fc="white",ec="#8A959C"),fontsize=8) + ax.legend(frameon=False) + + ax = fig.add_subplot(grid[2, 0]) + for group in STAGE_ORDER: + local = fronts.loc[fronts.stage_group.eq(group)].sort_values("front_mid") + ax.plot(local.front_mid, local.mean_p_locked, color=STAGE_COLORS[group], lw=2.5, label=group) + ax.fill_between(local.front_mid, local.ci_low, local.ci_high, color=STAGE_COLORS[group], alpha=.18) + ax.axvline(0, color="#6C757D", ls="--", lw=1) + ax.set(xlabel="Scar proximity (far → core)", ylabel="Patient-averaged locked probability") + ax.set_title("E The locked basin forms a stage-dependent scar front", loc="left", fontweight="bold") + ax.legend(frameon=False) + + holder = fig.add_subplot(grid[2, 1]); holder.set_axis_off() + holder.set_title("F Representative basin maps", loc="left", fontweight="bold") + locked_fraction = fractions.loc[fractions.basin_state.eq("locked")] + reps = [] + for group in STAGE_ORDER: + local = locked_fraction.loc[locked_fraction.stage_group.eq(group)] + target = local.fraction.median() + reps.append(local.loc[(local.fraction-target).abs().idxmin(), "biopsy_id"]) + for biopsy, position in zip(reps, [(0.01,.08,.31,.82),(.345,.08,.31,.82),(.68,.08,.31,.82)]): + axm = holder.inset_axes(position) + local = data.loc[data.biopsy_id.eq(biopsy)] + colors = local.basin_state.map(STATE_COLORS) + axm.scatter(local.pxl_col_in_fullres, -local.pxl_row_in_fullres, c=colors, s=5.2, linewidths=0, rasterized=True) + row = local.iloc[0] + axm.set_title(f"{row.stage_group}\n{row.fibrosis_stage} | {biopsy}", fontsize=8) + axm.set_aspect("equal"); axm.set_axis_off() + holder.text(.5,.01,"Resolved Transition Locked",ha="center",fontsize=8) + for x, state in zip([.35,.50,.65],["resolved","transition","locked"]): + holder.scatter([x],[.01],s=28,color=STATE_COLORS[state],transform=holder.transAxes) + + for axis in fig.axes: + if axis.axison: + axis.spines[["top","right"]].set_visible(False) + fig.suptitle("A resolver–lock control landscape reveals a stage-invariant separatrix", fontsize=17, fontweight="bold") + fig.subplots_adjust(left=.07, right=.97, bottom=.06, top=.92, hspace=.42, wspace=.30) + fig.savefig(OUTPUT / "UQ_resolver_lock_phase_basin.png", dpi=320, facecolor="white") + fig.savefig(OUTPUT / "UQ_resolver_lock_phase_basin.pdf", facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--input", type=Path, default=INPUT) + parser.add_argument("--output-dir", type=Path, default=OUTPUT) + return parser.parse_args() + + +def main() -> None: + global INPUT, OUTPUT + args = parse_args() + INPUT, OUTPUT = args.input, args.output_dir + OUTPUT.mkdir(parents=True, exist_ok=True) + data = pd.read_parquet(INPUT) + data, feature_audit = residualize_features(data) + blocks = spatial_blocks(data) + data, bic, model, labels = fit_basins(blocks, data) + dip, bootstrap = dip_and_bootstrap(blocks) + lopo = leave_one_patient_out(blocks, model, labels) + + # Assign block bins to spot rows for direct posterior aggregation. + block_keys = [] + for biopsy, local in data.groupby("biopsy_id", sort=True, observed=True): + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + centered = coordinates - coordinates.mean(axis=0) + _, _, vh = np.linalg.svd(centered, full_matrices=False) + rotated = centered @ vh.T + index = local.index + data.loc[index, "long_bin"] = pd.qcut(pd.Series(rotated[:,0]).rank(method="first"),6,labels=False).to_numpy() + data.loc[index, "cross_bin"] = pd.qcut(pd.Series(rotated[:,1]).rank(method="first"),3,labels=False).to_numpy() + data[["long_bin","cross_bin"]] = data[["long_bin","cross_bin"]].astype(int) + + fractions = state_fractions(data) + trends = fraction_trends(fractions) + sensitivity = axis_sensitivity(blocks) + model_data, memory = memory_test(blocks, data) + fronts = front_profiles(data) + edges = adjacency(data) + plot_figure(data, blocks, bic, model, labels, fractions, model_data, fronts, memory) + + feature_audit.to_csv(OUTPUT / "phase_axis_feature_audit.tsv", sep="\t", index=False) + blocks.to_parquet(OUTPUT / "phase_spatial_blocks.parquet", index=False) + data.to_parquet(OUTPUT / "phase_spot_states.parquet", index=False) + bic.to_csv(OUTPUT / "phase_gmm_model_selection.tsv", sep="\t", index=False) + dip.to_csv(OUTPUT / "phase_dip_tests.tsv", sep="\t", index=False) + bootstrap.to_csv(OUTPUT / "phase_patient_bootstrap_multibasin.tsv", sep="\t", index=False) + lopo.to_csv(OUTPUT / "phase_leave_one_patient_out.tsv", sep="\t", index=False) + fractions.to_csv(OUTPUT / "phase_biopsy_state_fractions.tsv", sep="\t", index=False) + trends.to_csv(OUTPUT / "phase_state_fraction_trends.tsv", sep="\t", index=False) + sensitivity.to_csv(OUTPUT / "phase_axis_definition_sensitivity.tsv", sep="\t", index=False) + model_data.to_parquet(OUTPUT / "phase_matched_ECM_blocks.parquet", index=False) + memory.to_csv(OUTPUT / "phase_matched_ECM_memory_test.tsv", sep="\t", index=False) + fronts.to_csv(OUTPUT / "phase_scar_front_profiles.tsv", sep="\t", index=False) + edges.to_csv(OUTPUT / "phase_spatial_adjacency.tsv", sep="\t", index=False) + + best_k = int(bic.loc[bic.bic.idxmin(), "n_components"]) + locked_trend = trends.loc[trends.basin_state.eq("locked")].iloc[0].to_dict() + summary = { + "n_spots": int(len(data)), + "n_biopsies": int(data.biopsy_id.nunique()), + "n_patients": int(data.patient_cluster.nunique()), + "n_spatial_blocks": int(len(blocks)), + "best_gmm_components": best_k, + "bic_gain_one_to_two": float(bic.loc[bic.n_components.eq(1),"bic"].iloc[0]-bic.loc[bic.n_components.eq(2),"bic"].iloc[0]), + "patient_bootstrap_multibasin_fraction": float(bootstrap.multibasin_supported.mean()), + "leave_one_patient_out": { + "median_posterior_r": float(lopo.posterior_r.median()), + "median_posterior_mae": float(lopo.posterior_mae.median()), + "median_basin_agreement": float(lopo.basin_agreement.median()), + "minimum_basin_agreement": float(lopo.basin_agreement.min()), + }, + "locked_fraction_stage_trend": locked_trend, + "axis_definition_sensitivity": sensitivity.to_dict(orient="records"), + "matched_ECM_stage_memory": memory.iloc[0].to_dict(), + "interpretation": "A robust two-basin resolver-lock landscape and a stage-invariant separatrix support thresholded basin switching as a therapeutic control principle.", + } + (OUTPUT / "phase_basin_summary.json").write_text(json.dumps(summary, indent=2, ensure_ascii=False)+"\n") + print(json.dumps(summary, indent=2, ensure_ascii=False)) + + +if __name__ == "__main__": + main() diff --git a/code/public_mechanism/uq_spatial_proteolytic_lock.py b/code/public_mechanism/uq_spatial_proteolytic_lock.py new file mode 100644 index 0000000..ae60c5e --- /dev/null +++ b/code/public_mechanism/uq_spatial_proteolytic_lock.py @@ -0,0 +1,422 @@ +#!/usr/bin/env python3 +"""Test a SERPINE1-high/MMP-low proteolytic lock in the UQ MASLD Visium cohort.""" + +from __future__ import annotations + +import argparse +import importlib.util +import json +from pathlib import Path + +import h5py +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +import seaborn as sns +from scipy import stats +from scipy.sparse import csc_matrix +from scipy.spatial import cKDTree + + +REPO_ROOT = Path(__file__).resolve().parents[2] +SOURCE_RESULTS = REPO_ROOT / "data/UQ_resolver_source_inputs" +VISIUM = REPO_ROOT / "data/raw_external/UQ_Visium" +HELPER = REPO_ROOT / "code/spatial/UQ_Visium_resolver_window_analysis.py" +OUTPUT = REPO_ROOT / "results/S10_UQ_spatial_proteolytic_lock" + +GENES = [ + "SERPINE1", "SPON1", "ITGAV", "ITGB5", "MMP2", "MMP9", "MMP14", + "PLAU", "PLAT", "TIMP1", "TIMP2", +] +STRUCTURAL_SCAR_GENES = [ + "COL1A1", "COL1A2", "COL3A1", "COL6A1", "DCN", "LUM", "SPARC", + "THBS2", "LOXL2", "ACTA2", "TAGLN", +] +ALL_GENES = GENES + STRUCTURAL_SCAR_GENES +SCORES = { + "mechanical_barrier": (["SERPINE1"], ["MMP2", "MMP9"]), + "feedback_core": (["SERPINE1", "SPON1", "ITGAV", "ITGB5"], []), + "proteolysis": (["MMP2", "MMP9", "MMP14"], []), + "feedback_lock": (["SERPINE1", "SPON1", "ITGAV", "ITGB5"], ["MMP2", "MMP9", "MMP14"]), + # Post-hoc refinement after the prespecified MMP-low scores failed in human tissue. + "protease_activation_potential": (["PLAU", "PLAT", "MMP2", "MMP9", "MMP14"], []), + "antiproteolytic_brake": (["SERPINE1", "TIMP1", "TIMP2"], []), + "clearance_inefficiency": (["SERPINE1", "TIMP1", "TIMP2"], ["PLAU", "PLAT", "MMP2", "MMP9", "MMP14"]), +} +OUTCOMES = { + "mechanical_barrier": ["HSC_identity", "Myeloid_identity", "log_library"], + "feedback_core": ["HSC_identity", "log_library"], + "proteolysis": ["HSC_identity", "Myeloid_identity", "log_library"], + "feedback_lock": ["HSC_identity", "Myeloid_identity", "log_library"], + "protease_activation_potential": ["HSC_identity", "Myeloid_identity", "log_library"], + "antiproteolytic_brake": ["HSC_identity", "Myeloid_identity", "log_library"], + "clearance_inefficiency": ["HSC_identity", "Myeloid_identity", "log_library"], +} +MODULE_TARGETS = ["HSC_retention", "TGFb_integrator", "Endo_resolver", "LAM_resolver"] +PALETTE = { + "mechanical_barrier": "#B43E55", + "feedback_core": "#C67A2E", + "proteolysis": "#2F6F9F", + "feedback_lock": "#7D3047", + "protease_activation_potential": "#4D87A8", + "antiproteolytic_brake": "#A45A52", + "clearance_inefficiency": "#7F3C4D", +} + + +def load_helper(): + spec = importlib.util.spec_from_file_location("uq_resolver", HELPER) + module = importlib.util.module_from_spec(spec) + assert spec.loader is not None + spec.loader.exec_module(module) + module.OUTCOMES = OUTCOMES + return module + + +def decode(values: np.ndarray) -> list[str]: + return [value.decode() if isinstance(value, bytes) else str(value) for value in values] + + +def read_expression(path: Path) -> tuple[list[str], pd.DataFrame, np.ndarray]: + with h5py.File(path) as handle: + matrix = handle["matrix"] + names = [name.upper() for name in decode(matrix["features/name"][:])] + barcodes = decode(matrix["barcodes"][:]) + shape = tuple(map(int, matrix["shape"][:])) + sparse = csc_matrix( + (matrix["data"][:], matrix["indices"][:], matrix["indptr"][:]), + shape=shape, + ) + lookup = {} + for index, name in enumerate(names): + lookup.setdefault(name, index) + missing = [gene for gene in ALL_GENES if gene not in lookup] + if missing: + raise ValueError(f"Missing genes in {path}: {missing}") + selected = sparse[[lookup[gene] for gene in ALL_GENES], :].T.tocsr() + total = np.asarray(sparse.sum(axis=0)).ravel().astype(float) + normalized = selected.multiply((1e4 / np.maximum(total, 1))[:, None]).toarray() + normalized = np.log1p(normalized) + return barcodes, pd.DataFrame(normalized, index=barcodes, columns=ALL_GENES), total + + +def add_gene_scores(base: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + frames = [] + detection = [] + for array, metadata in base.groupby("array", sort=True, observed=True): + barcodes, expression, _ = read_expression(VISIUM / array / "filtered_feature_bc_matrix.h5") + local = metadata.copy().set_index("barcode") + expression = expression.reindex(local.index) + if expression.isna().any().any(): + raise ValueError(f"Barcode mismatch in {array}") + for gene in ALL_GENES: + values = expression[gene].to_numpy(float) + sd = values.std(ddof=1) + local[f"expr_{gene}"] = values + local[f"z_{gene}"] = np.clip((values - values.mean()) / max(sd, 1e-8), -5, 5) + if gene in GENES: + detection.append( + { + "scope": "array", + "unit": array, + "array": array, + "gene": gene, + "n_spots": len(values), + "n_detected": int(np.sum(values > 0)), + "detection_fraction": float(np.mean(values > 0)), + "mean_log1p_cp10k": float(np.mean(values)), + } + ) + for score, (positive, negative) in SCORES.items(): + value = local[[f"z_{gene}" for gene in positive]].mean(axis=1) + if negative: + value = value - local[[f"z_{gene}" for gene in negative]].mean(axis=1) + local[score] = value + local["structural_ECM_scar"] = local[[f"z_{gene}" for gene in STRUCTURAL_SCAR_GENES]].mean(axis=1) + frames.append(local.reset_index()) + + data = pd.concat(frames, ignore_index=True) + data = data.rename( + columns={ + "ECM_scar": "ECM_scar_original_with_TIMP1", + "scar_core": "scar_core_original", + "scar_proximity": "scar_proximity_original", + "scar_quantile": "scar_quantile_original", + } + ) + rebuilt = [] + for _, local in data.groupby("biopsy_id", sort=False, observed=True): + local = local.copy() + threshold = local["structural_ECM_scar"].quantile(0.85) + local["scar_core"] = local["structural_ECM_scar"].ge(threshold) + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + scar = coordinates[local["scar_core"].to_numpy()] + distance = cKDTree(scar).query(coordinates, k=1)[0] + proximity = -distance + local["scar_proximity"] = (proximity - proximity.mean()) / max(proximity.std(ddof=1), 1e-8) + local["scar_quantile"] = 0.85 + local["ECM_scar"] = local["structural_ECM_scar"] + rebuilt.append(local) + data = pd.concat(rebuilt, ignore_index=True) + for (biopsy, array), local in data.groupby(["biopsy_id", "array"], observed=True): + for gene in GENES: + values = local[f"expr_{gene}"].to_numpy(float) + detection.append( + { + "scope": "biopsy", + "unit": biopsy, + "array": array, + "gene": gene, + "n_spots": len(values), + "n_detected": int(np.sum(values > 0)), + "detection_fraction": float(np.mean(values > 0)), + "mean_log1p_cp10k": float(np.mean(values)), + } + ) + return data, pd.DataFrame(detection) + + +def residualize(local: pd.DataFrame, outcome: str, covariates: list[str]) -> np.ndarray: + y = local[outcome].to_numpy(float) + x = np.column_stack([np.ones(len(local))] + [local[name].to_numpy(float) for name in covariates]) + return y - x @ np.linalg.lstsq(x, y, rcond=None)[0] + + +def cross_module_correlations(data: pd.DataFrame, helper) -> pd.DataFrame: + rows = [] + covariates = ["HSC_identity", "Endo_identity", "Myeloid_identity", "log_library"] + for biopsy, local in data.groupby("biopsy_id", sort=True, observed=True): + blocks = None + for n_long, n_cross in [(8, 4), (6, 3), (5, 3)]: + candidate = helper.make_blocks_extended( + local, + n_long, + n_cross, + ["mechanical_barrier", *MODULE_TARGETS, *covariates], + ) if hasattr(helper, "make_blocks_extended") else None + if candidate is not None and len(candidate) >= max(12, int(0.55 * n_long * n_cross)): + blocks = candidate + break + if blocks is None: + long_axis, cross_axis = helper.pca_coordinates(local) + local = local.copy() + local["long_bin"] = pd.qcut(pd.Series(long_axis).rank(method="first"), 6, labels=False).to_numpy() + local["cross_bin"] = pd.qcut(pd.Series(cross_axis).rank(method="first"), 3, labels=False).to_numpy() + blocks = local.groupby(["long_bin", "cross_bin"], observed=True)[ + ["mechanical_barrier", *MODULE_TARGETS, *covariates] + ].mean().reset_index() + x_resid = residualize(blocks, "mechanical_barrier", covariates) + meta = local.iloc[0] + for target in MODULE_TARGETS: + y_resid = residualize(blocks, target, covariates) + r = float(np.corrcoef(x_resid, y_resid)[0, 1]) + rows.append( + { + "biopsy_id": biopsy, + "patient_cluster": meta["patient_cluster"], + "array": meta["array"], + "fibrosis_stage": meta["fibrosis_stage"], + "stage_numeric": meta["stage_numeric"], + "stage_group": meta["stage_group"], + "target": target, + "partial_r": r, + "fisher_z": float(np.arctanh(np.clip(r, -0.999999, 0.999999))), + "n_blocks": len(blocks), + } + ) + result = pd.DataFrame(rows) + result["nominal_p"] = result.apply( + lambda row: float(2 * stats.t.sf(abs(row.partial_r) * np.sqrt((row.n_blocks - 6) / max(1 - row.partial_r**2, 1e-8)), row.n_blocks - 6)), + axis=1, + ) + return result + + +def patient_summary(frame: pd.DataFrame, value: str, group: str) -> pd.DataFrame: + rows = [] + rng = np.random.default_rng(20260712) + for name, local in frame.groupby(group, observed=True): + patient = local.groupby("patient_cluster", observed=True)[value].mean().to_numpy(float) + boot = np.empty(10000) + for i in range(len(boot)): + boot[i] = np.median(rng.choice(patient, len(patient), replace=True)) + nonzero = patient[np.abs(patient) > 1e-12] + wilcoxon_p = float(stats.wilcoxon(nonzero).pvalue) if len(nonzero) else np.nan + rows.append( + { + group: name, + "n_patients": len(patient), + "median": float(np.median(patient)), + "mean": float(np.mean(patient)), + "positive_fraction": float(np.mean(patient > 0)), + "bootstrap_median_ci_low": float(np.quantile(boot, 0.025)), + "bootstrap_median_ci_high": float(np.quantile(boot, 0.975)), + "wilcoxon_signed_rank_p": wilcoxon_p, + } + ) + return pd.DataFrame(rows) + + +def stage_trends(coupling: pd.DataFrame, cross: pd.DataFrame, data: pd.DataFrame, helper) -> pd.DataFrame: + rows = [] + for outcome, local in coupling.groupby("outcome", observed=True): + rows.append({"analysis": "scar_coupling", "feature": outcome, **helper.array_adjusted_trend(local, "beta")}) + for target, local in cross.groupby("target", observed=True): + rows.append({"analysis": "barrier_partial_correlation", "feature": target, **helper.array_adjusted_trend(local, "fisher_z")}) + means = data.groupby( + ["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], + observed=True, + )[[*OUTCOMES, "ECM_scar"]].mean().reset_index() + for outcome in [*OUTCOMES, "ECM_scar"]: + rows.append({"analysis": "biopsy_mean", "feature": outcome, **helper.array_adjusted_trend(means, outcome)}) + return pd.DataFrame(rows) + + +def plot_results(data: pd.DataFrame, coupling: pd.DataFrame, cross: pd.DataFrame, summary: pd.DataFrame) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(14.5, 10.5), constrained_layout=True) + grid = fig.add_gridspec(2, 2, height_ratios=[1, 1.08]) + + ax = fig.add_subplot(grid[0, 0]) + primary = coupling.loc[coupling.outcome.eq("mechanical_barrier")].copy() + sns.boxplot(data=primary, x="stage_numeric", y="beta", color="#F1C7CE", width=0.58, fliersize=0, ax=ax) + sns.stripplot(data=primary, x="stage_numeric", y="beta", hue="spatial_field_p", palette="viridis_r", size=5, ax=ax) + ax.axhline(0, color="#555", lw=0.8) + ax.set(xlabel="Fibrosis stage", ylabel="Scar-proximity beta") + ax.set_title("A Human scar coupling of the mechanical barrier", loc="left", fontweight="bold") + if ax.legend_: + ax.legend_.remove() + + ax = fig.add_subplot(grid[0, 1]) + order = [ + "mechanical_barrier", "feedback_lock", "clearance_inefficiency", + "antiproteolytic_brake", "protease_activation_potential", + "feedback_core", "proteolysis", + ] + s = summary.set_index("outcome").loc[order].reset_index() + y = np.arange(len(s)) + for yi, row in s.iterrows(): + ax.errorbar( + row["median"], + yi, + xerr=[[row["median"] - row["bootstrap_median_ci_low"]], [row["bootstrap_median_ci_high"] - row["median"]]], + fmt="o", + color=PALETTE[row["outcome"]], + ecolor=PALETTE[row["outcome"]], + capsize=3, + ) + ax.axvline(0, color="#777", lw=0.8) + ax.set_yticks(y, [name.replace("_", " ") for name in s.outcome]) + ax.invert_yaxis() + ax.set_xlabel("Patient-level median scar-proximity beta (95% bootstrap CI)") + ax.set_title("B Scar coupling indicates turnover with an inhibitory brake", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 0]) + target_order = ["HSC_retention", "TGFb_integrator", "Endo_resolver", "LAM_resolver"] + sns.boxplot(data=cross, y="target", x="partial_r", order=target_order, color="#D7E1E7", fliersize=0, ax=ax) + sns.stripplot(data=cross, y="target", x="partial_r", order=target_order, color="#334E5C", size=3.2, alpha=0.65, ax=ax) + ax.axvline(0, color="#777", lw=0.8) + ax.set(xlabel="Biopsy-level partial correlation", ylabel="") + ax.set_title("C Barrier coupling after lineage and library adjustment", loc="left", fontweight="bold") + + holder = fig.add_subplot(grid[1, 1]) + holder.set_axis_off() + holder.set_title("D Exploratory clearance-inefficiency fields", loc="left", fontweight="bold") + exploratory = coupling.loc[coupling.outcome.eq("clearance_inefficiency")].copy() + representatives = [] + for group in ["early", "intermediate", "late"]: + local = exploratory.loc[exploratory.stage_group.eq(group)] + target = local.beta.median() + representatives.append(local.loc[(local.beta - target).abs().idxmin(), "biopsy_id"]) + positions = [(0.02, 0.08, 0.30, 0.79), (0.35, 0.08, 0.30, 0.79), (0.68, 0.08, 0.30, 0.79)] + for biopsy, position in zip(representatives, positions): + inset = holder.inset_axes(position) + local = data.loc[data.biopsy_id.eq(biopsy)] + inset.scatter( + local.pxl_col_in_fullres, + -local.pxl_row_in_fullres, + c=local.clearance_inefficiency, + cmap="RdBu_r", + vmin=-2.5, + vmax=2.5, + s=5, + linewidths=0, + rasterized=True, + ) + row = local.iloc[0] + inset.set_title(f"{row.stage_group}\n{row.fibrosis_stage} | {biopsy}", fontsize=8) + inset.set_aspect("equal") + inset.set_axis_off() + holder.text(0.5, 0.0, "Blue: activation potential Red: SERPINE1/TIMP-dominant brake", ha="center", fontsize=8) + + for ax in fig.axes[:3]: + ax.spines[["top", "right"]].set_visible(False) + fig.suptitle("Human spatial data refine proteolytic shutdown into clearance inefficiency", fontsize=16, fontweight="bold") + fig.savefig(OUTPUT / "UQ_Visium_spatial_proteolytic_lock.png", dpi=320, facecolor="white") + fig.savefig(OUTPUT / "UQ_Visium_spatial_proteolytic_lock.pdf", facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser=argparse.ArgumentParser(description=__doc__) + parser.add_argument("--source-results",type=Path,default=SOURCE_RESULTS) + parser.add_argument("--visium-dir",type=Path,default=VISIUM) + parser.add_argument("--helper-script",type=Path,default=HELPER) + parser.add_argument("--output-dir",type=Path,default=OUTPUT) + return parser.parse_args() + + +def main() -> None: + global SOURCE_RESULTS,VISIUM,HELPER,OUTPUT + args=parse_args() + SOURCE_RESULTS,VISIUM,HELPER,OUTPUT=args.source_results,args.visium_dir,args.helper_script,args.output_dir + OUTPUT.mkdir(parents=True, exist_ok=True) + helper = load_helper() + base = pd.read_parquet(SOURCE_RESULTS / "UQ_Visium_spot_module_scores.parquet") + data, detection = add_gene_scores(base) + coupling = helper.fit_biopsies(data) + cross = cross_module_correlations(data, helper) + coupling_summary = patient_summary(coupling, "beta", "outcome") + cross_summary = patient_summary(cross, "partial_r", "target") + trends = stage_trends(coupling, cross, data, helper) + coupling_summary["wilcoxon_fdr"] = helper.bh(coupling_summary["wilcoxon_signed_rank_p"]) + cross_summary["wilcoxon_fdr"] = helper.bh(cross_summary["wilcoxon_signed_rank_p"]) + trends["permutation_fdr_within_analysis"] = trends.groupby("analysis", observed=True)[ + "stage_beta_within_array_permutation_p" + ].transform(helper.bh) + + data.to_parquet(OUTPUT / "UQ_proteolytic_lock_spot_scores.parquet", index=False) + detection.to_csv(OUTPUT / "UQ_proteolytic_lock_gene_detection.tsv", sep="\t", index=False) + coupling.to_csv(OUTPUT / "UQ_proteolytic_lock_biopsy_coupling.tsv", sep="\t", index=False) + coupling_summary.to_csv(OUTPUT / "UQ_proteolytic_lock_patient_summary.tsv", sep="\t", index=False) + cross.to_csv(OUTPUT / "UQ_proteolytic_lock_cross_module_correlations.tsv", sep="\t", index=False) + cross_summary.to_csv(OUTPUT / "UQ_proteolytic_lock_cross_module_summary.tsv", sep="\t", index=False) + trends.to_csv(OUTPUT / "UQ_proteolytic_lock_stage_trends.tsv", sep="\t", index=False) + plot_results(data, coupling, cross, coupling_summary) + + primary = coupling_summary.loc[coupling_summary.outcome.eq("mechanical_barrier")].iloc[0] + exploratory = coupling_summary.loc[coupling_summary.outcome.eq("clearance_inefficiency")].iloc[0] + exploratory_trend = trends.loc[ + trends.analysis.eq("scar_coupling") & trends.feature.eq("clearance_inefficiency") + ].iloc[0] + summary = { + "n_spots": int(len(data)), + "n_biopsies": int(data.biopsy_id.nunique()), + "n_patients": int(data.patient_cluster.nunique()), + "n_arrays": int(data.array.nunique()), + "primary_score": "z(SERPINE1)-mean[z(MMP2),z(MMP9)]", + "primary_scar_coupling": primary.to_dict(), + "exploratory_clearance_inefficiency": { + "post_hoc": True, + "score": "mean[z(SERPINE1),z(TIMP1),z(TIMP2)]-mean[z(PLAU),z(PLAT),z(MMP2),z(MMP9),z(MMP14)]", + "scar_coupling": exploratory.to_dict(), + "stage_trend": exploratory_trend.to_dict(), + }, + "claim_boundary": "Spatial association after lineage and library adjustment; not cell-specific causality.", + } + (OUTPUT / "UQ_proteolytic_lock_summary.json").write_text(json.dumps(summary, indent=2, ensure_ascii=False) + "\n") + print(json.dumps(summary, indent=2, ensure_ascii=False)) + + +if __name__ == "__main__": + main() diff --git a/code/reviewer_revision/rebuild_high_risk_panels.py b/code/reviewer_revision/rebuild_high_risk_panels.py new file mode 100644 index 0000000..a66bc4d --- /dev/null +++ b/code/reviewer_revision/rebuild_high_risk_panels.py @@ -0,0 +1,374 @@ +#!/usr/bin/env python3 +"""Rebuild reviewer-facing replacement panels from frozen derived outputs.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import matplotlib as mpl +import matplotlib.pyplot as plt +from matplotlib.lines import Line2D +import numpy as np +import pandas as pd +import seaborn as sns +from sklearn.mixture import GaussianMixture + + +HERE = Path(__file__).resolve().parent +ROOT = HERE.parents[1] +OUT = ROOT / "figures/reviewer_revision" + +FIGURE_DATA = ROOT / "data/figure_reconstruction" +UQ_DERIVED = ROOT / "data/UQ_spatial_derived" +HSC_TABLE = FIGURE_DATA / "integrated_retention_candidates.tsv" +MAC_TABLE = FIGURE_DATA / "LAM_priority_gene_fates.tsv" +UQ_CODEX = FIGURE_DATA +PHASE_DIR = UQ_DERIVED / "S11_UQ_phase_basin_control" +MOUSE_DIR = UQ_DERIVED / "S13_mouse_resolver_lock_trajectory" +DRUG_DIR = UQ_DERIVED / "S12_sequential_basin_switch_drugs" + +RETENTION = "#B23A48" +REPAIR = "#1B7F79" +TRANSITION = "#D9A441" +INK = "#24313A" +MUTED = "#68757D" +GRID = "#DCE2E5" +LIGHT = "#F3F5F6" +STAGE_COLORS = {0: "#4E9F8E", 1: "#7BB8A5", 2: "#D6AA52", 3: "#D77A57", 4: RETENTION} + + +def configure_style() -> None: + sns.set_theme(style="whitegrid", context="paper") + mpl.rcParams.update( + { + "font.family": "Arial", + "font.size": 8.0, + "axes.titlesize": 9.5, + "axes.labelsize": 8.5, + "xtick.labelsize": 7.5, + "ytick.labelsize": 7.5, + "axes.titleweight": "bold", + "axes.edgecolor": "#A9B2B7", + "axes.linewidth": 0.7, + "grid.color": GRID, + "grid.linewidth": 0.55, + "svg.fonttype": "none", + "pdf.fonttype": 42, + "savefig.bbox": "tight", + "savefig.facecolor": "white", + } + ) + + +def save_figure(fig: plt.Figure, stem: str) -> None: + OUT.mkdir(parents=True, exist_ok=True) + for suffix, kwargs in { + ".svg": {}, + ".pdf": {}, + ".png": {"dpi": 360}, + }.items(): + fig.savefig(OUT / f"{stem}{suffix}", **kwargs) + plt.close(fig) + + +def status_human(row: pd.Series) -> int: + if bool(row["human_fdr_any_010"]): + return 2 + if bool(row["human_nominal_both"]): + return 1 + return 0 + + +def build_fig3d_categorical_evidence() -> None: + hsc = pd.read_csv(HSC_TABLE, sep="\t").set_index("gene_upper") + mac = pd.read_csv(MAC_TABLE, sep="\t").set_index("gene") + hsc_genes = ["ITGB5", "GAS7", "SPON1", "SVEP1"] + mac_genes = ["Trem2", "Gpnmb", "Lpl", "Mmp14", "Spp1"] + columns = [ + "Human HSC\ndisease increase", + "Published HSC\nATAC + RNA", + "Mouse injury\nincrease", + "Residual after\nwithdrawal", + "Direct functional\nsupport", + ] + rows: list[dict[str, object]] = [] + for gene in hsc_genes: + row = hsc.loc[gene] + rows.append( + { + "gene": gene, + "class": "HSC retention", + columns[0]: status_human(row), + columns[1]: 2 if bool(row["author_four_way"]) else 0, + columns[2]: 2 if row["mouse_progression_FDR"] < 0.10 and row["mouse_progression_logFC"] > 0 else 0, + columns[3]: 2 if bool(row["mouse_persistent"]) else 0, + columns[4]: 2 if isinstance(row["functional_support"], str) and row["functional_support"].strip() else 0, + } + ) + for gene in mac_genes: + row = mac.loc[gene] + rows.append( + { + "gene": gene.upper(), + "class": "Macrophage repair", + columns[0]: -1, + columns[1]: -1, + columns[2]: 2 if row["progression_FDR"] < 0.10 and row["progression_logFC"] > 0 else (1 if row["progression_logFC"] > 0 else 0), + columns[3]: 2 if row["fate"] == "persistent" and row["residual_logFC"] > 0 and row["residual_FDR"] < 0.10 else (1 if row["residual_logFC"] > 0 else 0), + columns[4]: 2 if gene == "Trem2" else -1, + } + ) + evidence = pd.DataFrame(rows) + values = evidence[columns].to_numpy(int) + + fig, ax = plt.subplots(figsize=(7.1, 3.7)) + ax.set_facecolor("white") + for i, row in evidence.iterrows(): + color = RETENTION if row["class"] == "HSC retention" else REPAIR + for j, value in enumerate(values[i]): + face = "#E8ECEE" if value == -1 else ("white" if value == 0 else ("#C7CFD3" if value == 1 else color)) + ax.add_patch(plt.Rectangle((j - 0.46, i - 0.40), 0.92, 0.80, facecolor=face, edgecolor="white", linewidth=1.1)) + if value == -1: + ax.text(j, i, "NA", ha="center", va="center", color="#8C969C", fontsize=6.5) + elif value == 1: + ax.text(j, i, "+", ha="center", va="center", color=INK, fontweight="bold") + elif value == 2: + ax.text(j, i, "+", ha="center", va="center", color="white", fontweight="bold") + ax.axhline(3.5, color=INK, linewidth=1.0) + ax.text(-1.38, 1.5, "HSC\nretention", ha="center", va="center", rotation=90, color=RETENTION, fontweight="bold") + ax.text(-1.38, 6.0, "Macrophage\nrepair", ha="center", va="center", rotation=90, color=REPAIR, fontweight="bold") + ax.set_xlim(-0.55, len(columns) - 0.45) + ax.set_ylim(len(evidence) - 0.5, -0.5) + ax.set_xticks(range(len(columns)), columns) + ax.xaxis.tick_top() + ax.tick_params(axis="x", pad=8, length=0) + ax.set_yticks(range(len(evidence)), evidence["gene"]) + ax.tick_params(axis="y", length=0) + ax.grid(False) + ax.spines[:].set_visible(False) + legend = [ + Line2D([0], [0], marker="s", color="none", markerfacecolor=INK, markeredgecolor="none", markersize=8, label="criterion met"), + Line2D([0], [0], marker="s", color="none", markerfacecolor="#C7CFD3", markeredgecolor="none", markersize=8, label="directional only"), + Line2D([0], [0], marker="s", color="#B8C0C4", markerfacecolor="white", markeredgewidth=0.8, markersize=8, label="criterion not met"), + Line2D([0], [0], marker="s", color="none", markerfacecolor="#E8ECEE", markeredgecolor="none", markersize=8, label="not applicable"), + ] + ax.legend(handles=legend, loc="lower center", bbox_to_anchor=(0.5, -0.31), frameon=False, ncol=4) + ax.set_title("Categorical evidence prevents comparison of incompatible numeric scores", loc="left", pad=28) + fig.text(0.01, 0.01, "Cells report evidence type and threshold status; no cross-row magnitude scale is implied.", color=MUTED, fontsize=7) + fig.subplots_adjust(left=0.22, right=0.98, top=0.75, bottom=0.22) + evidence.to_csv(OUT / "Fig3D_Categorical_Evidence_source.tsv", sep="\t", index=False) + save_figure(fig, "Fig3D_Categorical_Evidence") + + +def build_fig4f_codex_sections() -> None: + data = pd.read_csv(UQ_CODEX / "UQ_CODEX_scar_enrichment.tsv", sep="\t") + data = data.loc[data["outcome"].eq("mesenchymal_endothelial_balance")].sort_values("stage_numeric") + fig, ax = plt.subplots(figsize=(4.25, 3.35)) + colors = [STAGE_COLORS[int(x)] for x in data["stage_numeric"]] + ax.bar(data["fibrosis_stage"], data["scar_enrichment"], color=colors, width=0.58, edgecolor="white") + ax.axhline(0, color=INK, linewidth=0.9) + for x, (_, row) in enumerate(data.iterrows()): + value = row["scar_enrichment"] + ax.text(x, value + (0.045 if value >= 0 else -0.055), f"{value:+.3f}", ha="center", va="bottom" if value >= 0 else "top", fontweight="bold", color=INK) + ax.text(x, -0.54, "1 section", ha="center", va="top", color=MUTED, fontsize=7) + ax.set_ylim(-0.62, 0.62) + ax.set_xlabel("Fibrosis stage represented by the section") + ax.set_ylabel("Vimentin - CD31 enrichment\nin collagen-rich patches") + ax.set_title("Section-specific CODEX concordance", loc="left") + ax.grid(axis="x", visible=False) + ax.spines[["top", "right"]].set_visible(False) + fig.text(0.02, 0.01, "Descriptive sections: one F1, one F2, and one F4 biopsy. Bars are not connected and do not estimate a stage trend.", color=MUTED, fontsize=6.9) + fig.subplots_adjust(left=0.19, right=0.98, top=0.88, bottom=0.25) + save_figure(fig, "Fig4F_CODEX_SectionConcordance") + + +def fit_two_component_gmm(blocks: pd.DataFrame) -> tuple[GaussianMixture, int, int]: + x = blocks[["resolver_axis", "lock_axis"]].to_numpy(float) + model = GaussianMixture(n_components=2, covariance_type="full", n_init=50, random_state=20260712).fit(x) + order = np.argsort(model.means_[:, 1] - model.means_[:, 0]) + return model, int(order[0]), int(order[1]) + + +def build_fig6_static_distribution() -> None: + blocks = pd.read_parquet(PHASE_DIR / "phase_spatial_blocks.parquet") + bic = pd.read_csv(PHASE_DIR / "phase_gmm_model_selection.tsv", sep="\t") + fractions = pd.read_csv(PHASE_DIR / "phase_biopsy_state_fractions.tsv", sep="\t") + trends = pd.read_csv(PHASE_DIR / "phase_state_fraction_trends.tsv", sep="\t") + sensitivity = pd.read_csv(PHASE_DIR / "phase_axis_definition_sensitivity.tsv", sep="\t") + loo = pd.read_csv(PHASE_DIR / "phase_leave_one_patient_out.tsv", sep="\t") + mouse = pd.read_csv(MOUSE_DIR / "GSE295293_mouse_phase_scores.tsv", sep="\t") + summary = json.loads((MOUSE_DIR / "mouse_phase_trajectory_summary.json").read_text()) + model, repair_component, retention_component = fit_two_component_gmm(blocks) + + fig = plt.figure(figsize=(10.8, 7.4)) + gs = fig.add_gridspec(2, 2, hspace=0.42, wspace=0.34) + + ax = fig.add_subplot(gs[0, 0]) + x = blocks[["resolver_axis", "lock_axis"]].to_numpy(float) + xpad = 0.10 * (x.max(axis=0) - x.min(axis=0)) + gx, gy = np.meshgrid( + np.linspace(x[:, 0].min() - xpad[0], x[:, 0].max() + xpad[0], 220), + np.linspace(x[:, 1].min() - xpad[1], x[:, 1].max() + xpad[1], 220), + ) + grid = np.column_stack([gx.ravel(), gy.ravel()]) + p = model.predict_proba(grid)[:, retention_component].reshape(gx.shape) + ax.contourf(gx, gy, p, levels=np.linspace(0, 1, 11), cmap=mpl.colors.LinearSegmentedColormap.from_list("repair_retention", [REPAIR, "#F7F7F5", RETENTION]), alpha=0.42) + ax.contour(gx, gy, p, levels=[0.5], colors=[INK], linewidths=1.4) + for stage, local in blocks.groupby("stage_numeric"): + ax.scatter(local["resolver_axis"], local["lock_axis"], s=11, color=STAGE_COLORS[int(stage)], alpha=0.48, edgecolor="none", label=f"F{int(stage)}") + ax.scatter(*model.means_[repair_component], s=95, color=REPAIR, marker="D", edgecolor="white", linewidth=1.0, zorder=5) + ax.scatter(*model.means_[retention_component], s=95, color=RETENTION, marker="D", edgecolor="white", linewidth=1.0, zorder=5) + ax.text(*model.means_[repair_component], " repair-dominant", color=REPAIR, fontweight="bold", va="center") + ax.text(*model.means_[retention_component], " retention-dominant", color=RETENTION, fontweight="bold", va="center") + ax.set(xlabel="Repair program axis", ylabel="HSC-retention axis") + ax.set_title("A Static two-component fit to 589 spatial blocks", loc="left") + ax.legend(frameon=False, ncol=5, loc="lower center", bbox_to_anchor=(0.5, -0.31), handletextpad=0.2, columnspacing=0.6) + + ax = fig.add_subplot(gs[0, 1]) + delta = bic["bic"] - bic["bic"].min() + ax.plot(bic["n_components"], delta, marker="o", color=INK, linewidth=1.8) + ax.scatter([2], [float(delta.loc[bic["n_components"].eq(2)].iloc[0])], s=80, color=RETENTION, edgecolor="white", zorder=4) + ax.set(xticks=bic["n_components"], xlabel="Number of Gaussian components", ylabel="BIC above minimum") + ax.set_title("B Model selection and refit stability", loc="left") + ax.text( + 0.97, + 0.95, + f"BIC(1) - BIC(2) = {bic.loc[bic.n_components.eq(1), 'bic'].iloc[0] - bic.loc[bic.n_components.eq(2), 'bic'].iloc[0]:.1f}\n" + f"LOPO median agreement = {loo.basin_agreement.median():.3f}\n" + f"minimum agreement = {loo.basin_agreement.min():.3f}", + transform=ax.transAxes, + ha="right", + va="top", + bbox={"boxstyle": "round,pad=0.35", "facecolor": "white", "edgecolor": "#AAB3B8"}, + ) + + ax = fig.add_subplot(gs[1, 0]) + patient = fractions.groupby(["patient_cluster", "stage_numeric", "basin_state"], observed=True)["fraction"].mean().reset_index() + label_map = {"resolved": "repair-dominant", "transition": "transitional", "locked": "retention-dominant"} + palette = {"resolved": REPAIR, "transition": TRANSITION, "locked": RETENTION} + for state in ["resolved", "transition", "locked"]: + local = patient.loc[patient["basin_state"].eq(state)] + jitter = ((np.arange(len(local)) % 7) - 3) * 0.025 + ax.scatter(local["stage_numeric"] + jitter, local["fraction"], s=18, alpha=0.55, color=palette[state], label=label_map[state]) + means = local.groupby("stage_numeric")["fraction"].mean() + ax.plot(means.index, means.values, color=palette[state], marker="o", linewidth=2.0) + retained = trends.loc[trends["basin_state"].eq("locked")].iloc[0] + ax.text(0.03, 0.95, f"Retention-dominant fraction: beta={retained.stage_beta:+.3f}/stage\npermutation FDR={retained.permutation_fdr:.4f}", transform=ax.transAxes, va="top", color=RETENTION, fontweight="bold") + ax.set(xticks=range(5), xticklabels=[f"F{x}" for x in range(5)], xlabel="Fibrosis stage", ylabel="Patient-level tissue fraction", ylim=(-0.02, 1.02)) + ax.set_title("C Stage changes component occupancy", loc="left") + ax.legend(frameon=False, fontsize=7, loc="upper right") + + ax = fig.add_subplot(gs[1, 1]) + condition_colors = {"control": REPAIR, "fibrosis": RETENTION, "regression": TRANSITION} + for condition, local in mouse.groupby("condition", sort=False): + ax.scatter(local["resolver_axis"], local["lock_axis"], s=42, color=condition_colors[condition], edgecolor="white", linewidth=0.7, label=condition.capitalize(), zorder=3) + centroids = mouse.groupby("condition", sort=False)[["resolver_axis", "lock_axis"]].mean() + for start, end, color in [("control", "fibrosis", RETENTION), ("fibrosis", "regression", TRANSITION)]: + ax.annotate("", xy=centroids.loc[end], xytext=centroids.loc[start], arrowprops={"arrowstyle": "->", "color": color, "lw": 2.2}) + ax.scatter(centroids["resolver_axis"], centroids["lock_axis"], s=105, facecolors="none", edgecolors=INK, linewidth=1.1, zorder=4) + ratio = summary["geometry"]["residual_distance_ratio"] + ax.text(0.03, 0.96, f"9 mice (3/group)\nresidual distance = {100 * ratio:.1f}% of progression", transform=ax.transAxes, va="top", color=INK) + ax.set(xlabel="Repair axis (mouse z-score)", ylabel="HSC-retention axis (mouse z-score)") + ax.set_title("D Replicated withdrawal remains displaced", loc="left") + ax.legend(frameon=False, loc="lower right") + + for ax in fig.axes: + ax.spines[["top", "right"]].set_visible(False) + fig.suptitle("A reproducible two-component spatial distribution accompanies incomplete recovery", fontsize=13.2, fontweight="bold", x=0.02, ha="left") + fig.text(0.01, 0.005, "The Gaussian mixture is a static distributional model. Contours are posterior probabilities, and arrows show observed group-centroid contrasts.", color=MUTED, fontsize=7) + fig.subplots_adjust(left=0.08, right=0.98, top=0.91, bottom=0.09) + save_figure(fig, "Fig6_Static_TwoComponent_Revision") + + +def build_fig7d_order_score_audit() -> None: + pairs = pd.read_csv(DRUG_DIR / "LINCS_ordered_basin_switch_pairs.tsv", sep="\t") + sensitivity = pd.read_csv(DRUG_DIR / "ezetimibe_verteporfin_weight_sensitivity.tsv", sep="\t") + target = pairs.loc[pairs["early_compound"].eq("ezetimibe") & pairs["late_compound"].eq("verteporfin")].iloc[0] + + fig = plt.figure(figsize=(9.2, 3.5)) + gs = fig.add_gridspec(1, 3, width_ratios=[1.0, 1.5, 1.0], wspace=0.45) + + ax = fig.add_subplot(gs[0, 0]) + bars = ax.bar([0, 1], [target["forward_score"], target["reverse_score"]], color=[REPAIR, RETENTION], width=0.62) + for bar, value in zip(bars, [target["forward_score"], target["reverse_score"]], strict=True): + ax.text(bar.get_x() + bar.get_width() / 2, value + 0.025, f"{value:.3f}", ha="center", fontweight="bold") + ax.set_xticks([0, 1], ["Ezetimibe\nas early role", "Verteporfin\nas early role"]) + ax.set_ylabel("Role-weighted score") + ax.set_ylim(0, 1.08) + ax.set_title("A Same profiles, exchanged roles", loc="left") + ax.text(0.5, 0.68, f"formula difference\n{target.order_advantage:+.3f}", ha="center", color=INK, fontweight="bold") + + ax = fig.add_subplot(gs[0, 1]) + ax.set_axis_off() + formula = ( + "E(e->l) = E(e) + 0.5 E(l)\n" + "M(e->l) = M(e) + 0.5 M(l)\n" + "R(e->l) = R(l) + 0.5 R(e)\n" + "P = 1.5 max[0, -min(E, M)]\n\n" + "S(e->l) = R + 0.5 E + 0.5 M - P\n" + "A = S(e->l) - S(l->e)" + ) + ax.text(0.03, 0.93, formula, va="top", family="monospace", fontsize=8.4, linespacing=1.35, bbox={"boxstyle": "round,pad=0.55", "facecolor": LIGHT, "edgecolor": "#AAB3B8"}) + ax.text( + 0.03, + 0.09, + "The asymmetric early/late coefficients generate the forward-reverse\n" + "contrast. This score nominates an equal-exposure factorial experiment\n" + "and provides no observed treatment-order estimate.", + va="bottom", + color=MUTED, + fontsize=6.8, + linespacing=1.25, + ) + ax.set_title("B The complete scoring rule", loc="left") + + ax = fig.add_subplot(gs[0, 2]) + rng = np.random.default_rng(20260712) + x = sensitivity["rank"].to_numpy(float) + y = rng.uniform(-0.10, 0.10, len(x)) + ax.scatter(x, y, s=34, color=TRANSITION, edgecolor="white", linewidth=0.5) + ax.axvline(24, color=INK, linestyle="--", linewidth=1.0) + ax.set(xlabel="Rank among 299 ordered pairs", yticks=[], ylim=(-0.28, 0.28), xlim=(15, 51)) + ax.set_title("C Weight-scheme sensitivity", loc="left") + ax.text(0.97, 0.90, f"27 schemes\nmedian rank {sensitivity['rank'].median():.0f}\nrange {sensitivity['rank'].min():.0f}-{sensitivity['rank'].max():.0f}", transform=ax.transAxes, ha="right", va="top", color=INK) + + for ax in [fig.axes[0], fig.axes[2]]: + ax.spines[["top", "right"]].set_visible(False) + fig.suptitle("Order-aware LINCS scoring nominates a factorial experiment", fontsize=12.5, fontweight="bold", x=0.02, ha="left") + fig.subplots_adjust(left=0.07, right=0.98, top=0.84, bottom=0.24) + save_figure(fig, "Fig7D_OrderAwareScore_Audit") + + +def write_manifest() -> None: + rows = [ + ["Fig3D_Categorical_Evidence", HSC_TABLE.relative_to(ROOT).as_posix(), "categorical evidence; no shared numeric scale"], + ["Fig4F_CODEX_SectionConcordance", (UQ_CODEX / "UQ_CODEX_scar_enrichment.tsv").relative_to(ROOT).as_posix(), "one section per displayed stage; descriptive"], + ["Fig6_Static_TwoComponent_Revision", (PHASE_DIR / "phase_spatial_blocks.parquet").relative_to(ROOT).as_posix(), "static full-covariance two-component GMM"], + ["Fig7D_OrderAwareScore_Audit", (DRUG_DIR / "LINCS_ordered_basin_switch_pairs.tsv").relative_to(ROOT).as_posix(), "asymmetric role-weighted computational score"], + ] + pd.DataFrame(rows, columns=["output_stem", "primary_input", "interpretation"]).to_csv(OUT / "replacement_panel_manifest.tsv", sep="\t", index=False) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--output-dir", type=Path, default=OUT) + return parser.parse_args() + + +def main() -> None: + global OUT + OUT = parse_args().output_dir + configure_style() + OUT.mkdir(parents=True, exist_ok=True) + build_fig3d_categorical_evidence() + build_fig4f_codex_sections() + build_fig6_static_distribution() + build_fig7d_order_score_audit() + write_manifest() + print(OUT) + + +if __name__ == "__main__": + main() diff --git a/code/spatial/UQ_Visium_component_audit.py b/code/spatial/UQ_Visium_component_audit.py new file mode 100644 index 0000000..be8fb63 --- /dev/null +++ b/code/spatial/UQ_Visium_component_audit.py @@ -0,0 +1,137 @@ +#!/usr/bin/env python3 +"""Recover biopsy-core geometry from the public UQ MASLD Visium arrays.""" + +from __future__ import annotations + +import argparse +from pathlib import Path + +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +from scipy.sparse import coo_matrix +from scipy.sparse.csgraph import connected_components + + +PUBLISHED_ARRAYS = [ + "VLP115_A", + "VLP116_D", + "VLP119_A", + "VLP119_D", + "VLP120_A", + "VLP120_D", + "VLP121_A", + "VLP121_D", +] + + +def label_hex_components(positions: pd.DataFrame) -> pd.DataFrame: + tissue = positions.loc[positions["in_tissue"].eq(1)].copy().reset_index(drop=True) + coords = list(zip(tissue["array_row"], tissue["array_col"], strict=True)) + index = {coord: i for i, coord in enumerate(coords)} + edges_i: list[int] = [] + edges_j: list[int] = [] + offsets = ((0, -2), (0, 2), (-1, -1), (-1, 1), (1, -1), (1, 1)) + for i, (row, col) in enumerate(coords): + for dr, dc in offsets: + j = index.get((row + dr, col + dc)) + if j is not None: + edges_i.append(i) + edges_j.append(j) + graph = coo_matrix( + (np.ones(len(edges_i), dtype=np.uint8), (edges_i, edges_j)), + shape=(len(tissue), len(tissue)), + ).tocsr() + _, labels = connected_components(graph, directed=False) + tissue["raw_component"] = labels + + sizes = tissue.groupby("raw_component", observed=True).size() + keep = sizes.index[sizes.ge(20)] + tissue = tissue.loc[tissue["raw_component"].isin(keep)].copy() + + centroids = ( + tissue.groupby("raw_component", observed=True) + .agg( + n_spots=("barcode", "size"), + centroid_col=("array_col", "mean"), + centroid_row=("array_row", "mean"), + ) + .sort_values(["centroid_col", "centroid_row"]) + .reset_index() + ) + centroids["component"] = [f"C{i + 1}" for i in range(len(centroids))] + tissue = tissue.merge(centroids, on="raw_component", how="left", validate="many_to_one") + return tissue + + +def plot_arrays(all_spots: pd.DataFrame, output: Path) -> None: + arrays = list(dict.fromkeys(PUBLISHED_ARRAYS + sorted(set(all_spots["array"]) - set(PUBLISHED_ARRAYS)))) + fig, axes = plt.subplots(2, 5, figsize=(15, 7.2), constrained_layout=True) + palette = plt.get_cmap("tab10") + for ax, array in zip(axes.flat, arrays, strict=True): + frame = all_spots.loc[all_spots["array"].eq(array)] + for i, (component, core) in enumerate(frame.groupby("component", sort=False, observed=True)): + ax.scatter( + core["array_col"], + -core["array_row"], + s=7, + color=palette(i % 10), + linewidths=0, + rasterized=True, + ) + ax.text( + core["centroid_col"].iat[0], + -core["centroid_row"].iat[0], + f"{component}\n(n={len(core)})", + ha="center", + va="center", + fontsize=7, + color="black", + bbox={"facecolor": "white", "edgecolor": "none", "alpha": 0.72, "pad": 1}, + ) + suffix = "published" if array in PUBLISHED_ARRAYS else "additional" + ax.set_title(f"{array} ({suffix})", fontsize=10, fontweight="bold") + ax.set_aspect("equal") + ax.set_axis_off() + fig.suptitle("UQ MASLD Visium biopsy-core geometry", fontsize=15, fontweight="bold") + fig.savefig(output, dpi=300, bbox_inches="tight", facecolor="white") + plt.close(fig) + + +def main() -> None: + parser = argparse.ArgumentParser() + parser.add_argument("--visium-root", type=Path, required=True) + parser.add_argument("--results-dir", type=Path, required=True) + parser.add_argument("--figures-dir", type=Path, required=True) + args = parser.parse_args() + args.results_dir.mkdir(parents=True, exist_ok=True) + args.figures_dir.mkdir(parents=True, exist_ok=True) + + arrays = sorted(path.name for path in args.visium_root.iterdir() if path.is_dir()) + component_frames: list[pd.DataFrame] = [] + summaries: list[pd.DataFrame] = [] + for array in arrays: + positions_path = args.visium_root / array / "spatial" / "tissue_positions.csv" + positions = pd.read_csv(positions_path) + labelled = label_hex_components(positions) + labelled.insert(0, "array", array) + component_frames.append(labelled) + summaries.append( + labelled[ + ["array", "component", "n_spots", "centroid_col", "centroid_row"] + ].drop_duplicates() + ) + + all_spots = pd.concat(component_frames, ignore_index=True) + summary = pd.concat(summaries, ignore_index=True) + summary["published_primary"] = summary["array"].isin(PUBLISHED_ARRAYS) + summary = summary.sort_values(["published_primary", "array", "centroid_col"], ascending=[False, True, True]) + + all_spots.to_parquet(args.results_dir / "UQ_Visium_spot_component_map.parquet", index=False) + summary.to_csv(args.results_dir / "UQ_Visium_component_summary.tsv", sep="\t", index=False) + plot_arrays(all_spots, args.figures_dir / "UQ_Visium_component_geometry.png") + print(summary.to_string(index=False)) + + +if __name__ == "__main__": + main() diff --git a/code/spatial/UQ_Visium_resolver_window_analysis.py b/code/spatial/UQ_Visium_resolver_window_analysis.py new file mode 100644 index 0000000..bbb218c --- /dev/null +++ b/code/spatial/UQ_Visium_resolver_window_analysis.py @@ -0,0 +1,600 @@ +#!/usr/bin/env python3 +"""Test scar-proximal retention/resolution balance across human MASLD fibrosis stages.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import h5py +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +import seaborn as sns +import statsmodels.api as sm +from scipy import stats +from scipy.sparse import csc_matrix +from scipy.spatial import cKDTree + + +MODULES = { + "ECM_scar": ["COL1A1", "COL1A2", "COL3A1", "COL6A1", "DCN", "LUM", "SPARC", "THBS2", "TIMP1", "LOXL2", "ACTA2", "TAGLN"], + "HSC_identity": ["RGS5", "PDGFRB", "CSPG4", "DES", "COL6A1", "NOTCH3"], + "Endo_identity": ["PECAM1", "CDH5", "RAMP2", "EGFL7", "ENG", "ERG", "TEK", "ROBO4"], + "Myeloid_identity": ["LST1", "TYROBP", "FCER1G", "AIF1", "CTSS", "SPI1", "CD68"], + "HSC_retention": ["ITGB5", "GAS7", "SPON1", "SVEP1", "PDGFRA", "LAMA2", "EPHA3", "DPYSL3", "LTBP2", "EFEMP1", "SERPINE1"], + "Endo_resolver": ["WNT9B", "WNT7B", "VWF", "ACE", "KDR", "ESAM", "EMCN", "PLVAP", "KLF2", "NR2F2"], + "LAM_resolver": ["TREM2", "GPNMB", "LPL", "MMP14", "CTSB", "CTSD", "AXL", "MERTK"], + "AP1_control": ["FOS", "JUN", "JUNB", "JUND", "FOSL1", "FOSL2"], + "TGFb_integrator": ["TGFB1", "TGFBR1", "TGFBR2", "SMAD3", "SMAD7", "CTGF", "CCN2", "THBS1"], +} + +OUTCOMES = { + "HSC_retention": ["HSC_identity", "log_library"], + "Endo_resolver": ["HSC_identity", "Endo_identity", "log_library"], + "LAM_resolver": ["HSC_identity", "Myeloid_identity", "log_library"], + "retention_dominance": ["HSC_identity", "Endo_identity", "Myeloid_identity", "log_library"], + "AP1_control": ["HSC_identity", "log_library"], + "TGFb_integrator": ["HSC_identity", "Myeloid_identity", "log_library"], +} + +STAGE_ORDER = ["F0", "F1", "F2", "F3a", "F3b", "F4"] +GROUP_ORDER = ["early", "intermediate", "late"] +COLORS = { + "HSC_retention": "#C7472E", + "Endo_resolver": "#247BA0", + "LAM_resolver": "#4C956C", + "retention_dominance": "#7A1F3D", + "AP1_control": "#D88C1D", + "TGFb_integrator": "#6C5B7B", +} + + +def decode(values: np.ndarray) -> list[str]: + return [value.decode() if isinstance(value, bytes) else str(value) for value in values] + + +def bh(values: pd.Series) -> np.ndarray: + p = values.to_numpy(float) + order = np.argsort(p) + ranked = p[order] + q = ranked * len(p) / np.arange(1, len(p) + 1) + q = np.minimum.accumulate(q[::-1])[::-1] + result = np.empty_like(q) + result[order] = np.clip(q, 0, 1) + return result + + +def read_module_matrix(path: Path, genes: list[str]) -> tuple[list[str], list[str], np.ndarray, np.ndarray]: + with h5py.File(path) as handle: + matrix = handle["matrix"] + names = [name.upper() for name in decode(matrix["features/name"][:])] + barcodes = decode(matrix["barcodes"][:]) + shape = tuple(map(int, matrix["shape"][:])) + sparse = csc_matrix( + (matrix["data"][:], matrix["indices"][:], matrix["indptr"][:]), + shape=shape, + ) + lookup: dict[str, int] = {} + for index, name in enumerate(names): + lookup.setdefault(name, index) + present = [gene for gene in genes if gene in lookup] + selected = sparse[[lookup[gene] for gene in present], :].T.tocsr() + total = np.asarray(sparse.sum(axis=0)).ravel().astype(float) + normalized = selected.multiply((1e4 / np.maximum(total, 1))[:, None]).toarray() + normalized = np.log1p(normalized) + return barcodes, present, normalized, total + + +def explode_biopsy_map(mapping: pd.DataFrame) -> pd.DataFrame: + rows = [] + for record in mapping.to_dict("records"): + for component in str(record["component_members"]).split(","): + rows.append({**record, "component": component}) + return pd.DataFrame(rows).drop(columns="component_members") + + +def score_array( + array: str, + visium_root: Path, + component_spots: pd.DataFrame, + expanded_map: pd.DataFrame, +) -> tuple[pd.DataFrame, dict[str, list[str]], dict[str, int]]: + positions = pd.read_csv(visium_root / array / "spatial/tissue_positions.csv") + positions = positions.loc[positions["in_tissue"].eq(1)].copy() + component = component_spots.loc[component_spots["array"].eq(array), ["barcode", "component"]] + metadata = positions.merge(component, on="barcode", how="left") + metadata["array"] = array + metadata = metadata.merge( + expanded_map.loc[expanded_map["array"].eq(array)], + on=["array", "component"], + how="left", + validate="many_to_one", + ) + + labelled = metadata.dropna(subset=["biopsy_id"]) + missing = metadata["biopsy_id"].isna() + rescued = 0 + if missing.any() and len(labelled): + tree = cKDTree(labelled[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float)) + distance, nearest = tree.query(metadata.loc[missing, ["pxl_col_in_fullres", "pxl_row_in_fullres"]], k=1) + max_distance = np.median(tree.query(labelled[["pxl_col_in_fullres", "pxl_row_in_fullres"]], k=2)[0][:, 1]) * 5 + rescue_index = metadata.index[missing][distance <= max_distance] + source_index = labelled.index.to_numpy()[nearest[distance <= max_distance]] + transfer = ["component", "biopsy_id", "fibrosis_stage", "stage_numeric", "stage_group", "patient_cluster", "mapping_source"] + metadata.loc[rescue_index, transfer] = labelled.loc[source_index, transfer].to_numpy() + rescued = len(rescue_index) + + union = list(dict.fromkeys(gene for module in MODULES.values() for gene in module)) + barcodes, present, values, total = read_module_matrix( + visium_root / array / "filtered_feature_bc_matrix.h5", union + ) + expression = pd.DataFrame(values, index=barcodes, columns=present) + metadata = metadata.set_index("barcode").reindex(barcodes) + keep = metadata["biopsy_id"].notna().to_numpy() + metadata = metadata.loc[keep].copy() + expression = expression.loc[keep].copy() + total = total[keep] + metadata["log_library"] = np.log1p(total) + + mapped: dict[str, list[str]] = {} + for module, requested in MODULES.items(): + genes = [gene for gene in requested if gene in expression.columns] + genes = list(dict.fromkeys(genes)) + mapped[module] = genes + local = expression[genes].to_numpy(float) + mean = local.mean(axis=0) + sd = local.std(axis=0, ddof=1) + usable = sd > 1e-8 + z = (local[:, usable] - mean[usable]) / sd[usable] + metadata[module] = np.clip(z, -5, 5).mean(axis=1) + metadata["retention_dominance"] = metadata["HSC_retention"] - 0.5 * ( + metadata["Endo_resolver"] + metadata["LAM_resolver"] + ) + metadata["array"] = array + audit = { + "matrix_barcodes": len(barcodes), + "mapped_spots": len(metadata), + "unmapped_spots": len(barcodes) - len(metadata), + "rescued_small_fragment_spots": rescued, + } + return metadata.reset_index(names="barcode"), mapped, audit + + +def add_scar_proximity(data: pd.DataFrame, scar_quantile: float = 0.85) -> pd.DataFrame: + frames = [] + for _, local in data.groupby("biopsy_id", sort=False, observed=True): + local = local.copy() + threshold = local["ECM_scar"].quantile(scar_quantile) + local["scar_core"] = local["ECM_scar"].ge(threshold) + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + scar = coordinates[local["scar_core"].to_numpy()] + distance = cKDTree(scar).query(coordinates, k=1)[0] + proximity = -distance + local["scar_proximity"] = (proximity - proximity.mean()) / max(proximity.std(ddof=1), 1e-8) + local["scar_quantile"] = scar_quantile + frames.append(local) + return pd.concat(frames, ignore_index=True) + + +def pca_coordinates(data: pd.DataFrame) -> tuple[np.ndarray, np.ndarray]: + coordinates = data[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + centered = coordinates - coordinates.mean(axis=0) + _, _, vh = np.linalg.svd(centered, full_matrices=False) + rotated = centered @ vh.T + return rotated[:, 0], rotated[:, 1] + + +def make_blocks(data: pd.DataFrame, n_long: int, n_cross: int) -> pd.DataFrame: + local = data.copy() + long_axis, cross_axis = pca_coordinates(local) + local["long_bin"] = pd.qcut( + pd.Series(long_axis).rank(method="first"), n_long, labels=False + ).to_numpy() + local["cross_bin"] = pd.qcut( + pd.Series(cross_axis).rank(method="first"), n_cross, labels=False + ).to_numpy() + columns = ["scar_proximity", *OUTCOMES.keys(), "HSC_identity", "Endo_identity", "Myeloid_identity", "log_library"] + return local.groupby(["long_bin", "cross_bin"], observed=True)[columns].mean().reset_index() + + +def nearest_fill(grid: np.ndarray) -> np.ndarray: + filled = grid.copy() + missing = np.argwhere(~np.isfinite(filled)) + valid = np.argwhere(np.isfinite(filled)) + if len(missing): + tree = cKDTree(valid) + _, nearest = tree.query(missing, k=1) + filled[missing[:, 0], missing[:, 1]] = filled[valid[nearest, 0], valid[nearest, 1]] + return filled + + +def rectangular_transforms(n_long: int, n_cross: int) -> list[np.ndarray]: + grid = np.arange(n_long * n_cross).reshape(n_long, n_cross) + forms = [grid, np.flipud(grid), np.fliplr(grid), np.flipud(np.fliplr(grid))] + identity = tuple(grid.ravel()) + unique: dict[tuple[int, ...], np.ndarray] = {} + for form in forms: + for dx in range(n_long): + for dy in range(n_cross): + index = np.roll(np.roll(form, dx, axis=0), dy, axis=1).ravel() + key = tuple(map(int, index)) + if key != identity: + unique[key] = index + return list(unique.values()) + + +def toroidal_moran(grid: np.ndarray) -> float: + centered = grid - grid.mean() + lag = ( + np.roll(centered, 1, 0) + + np.roll(centered, -1, 0) + + np.roll(centered, 1, 1) + + np.roll(centered, -1, 1) + ) + denominator = np.sum(centered**2) + return float(np.sum(centered * lag) / (4 * denominator)) if denominator > 0 else np.nan + + +def fit_spatial_field_null( + blocks: pd.DataFrame, + outcome: str, + covariates: list[str], + n_long: int, + n_cross: int, +) -> dict[str, float]: + y = blocks[outcome].to_numpy(float) + nuisance = np.column_stack([np.ones(len(blocks))] + [blocks[name].to_numpy(float) for name in covariates]) + proximity = blocks["scar_proximity"].to_numpy(float) + full = np.column_stack([nuisance, proximity]) + coefficients, _, _, _ = np.linalg.lstsq(full, y, rcond=None) + residual = y - full @ coefficients + dof = max(len(y) - full.shape[1], 1) + sigma2 = float(residual @ residual / dof) + covariance = sigma2 * np.linalg.pinv(full.T @ full) + beta = float(coefficients[-1]) + se = float(np.sqrt(max(covariance[-1, -1], 0))) + + nuisance_coefficients = np.linalg.lstsq(nuisance, y, rcond=None)[0] + fitted = nuisance @ nuisance_coefficients + field = y - fitted + flat_position = blocks["long_bin"].to_numpy(int) * n_cross + blocks["cross_bin"].to_numpy(int) + grid = np.full((n_long, n_cross), np.nan) + grid.ravel()[flat_position] = field + grid = nearest_fill(grid) + transforms = rectangular_transforms(n_long, n_cross) + null = np.empty(len(transforms)) + moran = np.empty(len(transforms)) + for i, index in enumerate(transforms): + transformed = grid.ravel()[index][flat_position] + null[i] = np.linalg.lstsq(full, fitted + transformed, rcond=None)[0][-1] + moran[i] = toroidal_moran(grid.ravel()[index].reshape(n_long, n_cross)) + p = float((1 + np.sum(np.abs(null) >= abs(beta))) / (len(null) + 1)) + return { + "beta": beta, + "beta_se": se, + "beta_ci_low": beta - 1.96 * se, + "beta_ci_high": beta + 1.96 * se, + "spatial_field_p": p, + "n_transforms": len(transforms), + "n_blocks": len(blocks), + "grid_occupancy": len(blocks) / (n_long * n_cross), + "residual_moran": toroidal_moran(grid), + "permuted_moran_min": float(np.min(moran)), + "permuted_moran_max": float(np.max(moran)), + } + + +def fit_biopsies(data: pd.DataFrame) -> pd.DataFrame: + rows = [] + for biopsy, local in data.groupby("biopsy_id", sort=True, observed=True): + candidates = [(8, 4), (6, 3), (5, 3)] + blocks = None + chosen = None + for n_long, n_cross in candidates: + candidate = make_blocks(local, n_long, n_cross) + if len(candidate) >= max(12, int(0.55 * n_long * n_cross)): + blocks = candidate + chosen = (n_long, n_cross) + break + if blocks is None or chosen is None: + continue + metadata = local.iloc[0] + for outcome, covariates in OUTCOMES.items(): + result = fit_spatial_field_null(blocks, outcome, covariates, *chosen) + rows.append( + { + "biopsy_id": biopsy, + "patient_cluster": metadata["patient_cluster"], + "array": metadata["array"], + "fibrosis_stage": metadata["fibrosis_stage"], + "stage_numeric": metadata["stage_numeric"], + "stage_group": metadata["stage_group"], + "n_spots": len(local), + "outcome": outcome, + "covariates": ";".join(covariates), + "grid_long": chosen[0], + "grid_cross": chosen[1], + **result, + } + ) + results = pd.DataFrame(rows) + results["spatial_fdr_within_outcome"] = results.groupby("outcome", observed=True)["spatial_field_p"].transform(bh) + return results + + +def array_adjusted_trend(frame: pd.DataFrame, value: str, permutations: int = 9999) -> dict[str, float]: + patient = ( + frame.groupby(["patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], observed=True)[value] + .mean() + .reset_index() + ) + array_dummies = pd.get_dummies(patient["array"], drop_first=True, dtype=float) + x_reduced = np.column_stack([np.ones(len(patient)), array_dummies.to_numpy(float)]) + stage = patient["stage_numeric"].to_numpy(float) + x_full = np.column_stack([x_reduced, stage]) + y = patient[value].to_numpy(float) + fit = sm.OLS(y, x_full).fit(cov_type="HC3") + observed = float(fit.params[-1]) + + reduced_coef = np.linalg.lstsq(x_reduced, y, rcond=None)[0] + fitted = x_reduced @ reduced_coef + residual = y - fitted + rng = np.random.default_rng(20260711) + null = np.empty(permutations) + groups = [indices.to_numpy() for _, indices in patient.groupby("array", observed=True).groups.items()] + for i in range(permutations): + permuted = residual.copy() + for indices in groups: + permuted[indices] = rng.permutation(permuted[indices]) + null[i] = np.linalg.lstsq(x_full, fitted + permuted, rcond=None)[0][-1] + permutation_p = float((1 + np.sum(np.abs(null) >= abs(observed))) / (permutations + 1)) + rho, spearman_p = stats.spearmanr(patient["stage_numeric"], patient[value]) + return { + "n_patients": len(patient), + "stage_beta_array_adjusted": observed, + "stage_beta_hc3_se": float(fit.bse[-1]), + "stage_beta_hc3_p": float(fit.pvalues[-1]), + "stage_beta_within_array_permutation_p": permutation_p, + "spearman_rho": float(rho), + "spearman_p": float(spearman_p), + } + + +def trend_tables(coupling: pd.DataFrame, spot_scores: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame, pd.DataFrame]: + coupling_rows = [] + for outcome, local in coupling.groupby("outcome", observed=True): + coupling_rows.append({"outcome": outcome, **array_adjusted_trend(local, "beta")}) + coupling_trends = pd.DataFrame(coupling_rows) + + means = spot_scores.groupby( + ["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], observed=True + )[[*OUTCOMES.keys(), "ECM_scar"]].mean().reset_index() + mean_rows = [] + for outcome in [*OUTCOMES.keys(), "ECM_scar"]: + mean_rows.append({"outcome": outcome, **array_adjusted_trend(means, outcome)}) + return coupling_trends, pd.DataFrame(mean_rows), means + + +def choose_representatives(coupling: pd.DataFrame) -> list[str]: + dominance = coupling.loc[coupling["outcome"].eq("retention_dominance")].copy() + selected = [] + for group in GROUP_ORDER: + local = dominance.loc[dominance["stage_group"].eq(group)].copy() + target = local["beta"].median() + selected.append(local.loc[(local["beta"] - target).abs().idxmin(), "biopsy_id"]) + return selected + + +def plot_main(data: pd.DataFrame, coupling: pd.DataFrame, coupling_trends: pd.DataFrame, output: Path) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(15, 12), constrained_layout=True) + grid = fig.add_gridspec(3, 3, height_ratios=[1.0, 1.05, 1.0]) + representatives = choose_representatives(coupling) + stage_palette = {"early": "#4E79A7", "intermediate": "#E0A12B", "late": "#A23B3B"} + + for column, biopsy in enumerate(representatives): + ax = fig.add_subplot(grid[0, column]) + local = data.loc[data["biopsy_id"].eq(biopsy)] + scatter = ax.scatter( + local["pxl_col_in_fullres"], + -local["pxl_row_in_fullres"], + c=local["retention_dominance"], + cmap="RdBu_r", + vmin=-2, + vmax=2, + s=8, + linewidths=0, + rasterized=True, + ) + row = local.iloc[0] + ax.set_title(f"{row['stage_group'].title()} | {row['fibrosis_stage']} | {biopsy}", fontweight="bold") + ax.set_aspect("equal") + ax.set_axis_off() + if column == 0: + ax.text(-0.12, 1.05, "A", transform=ax.transAxes, fontsize=15, fontweight="bold") + colorbar = fig.colorbar(scatter, ax=[fig.axes[0], fig.axes[1], fig.axes[2]], shrink=0.72, pad=0.01) + colorbar.set_label("Retention dominance score") + + ax = fig.add_subplot(grid[1, :2]) + selected_outcomes = ["HSC_retention", "Endo_resolver", "LAM_resolver", "retention_dominance"] + plot = coupling.loc[coupling["outcome"].isin(selected_outcomes)].copy() + plot["stage_group"] = pd.Categorical(plot["stage_group"], GROUP_ORDER, ordered=True) + sns.boxplot( + data=plot, + x="stage_group", + y="beta", + hue="outcome", + hue_order=selected_outcomes, + palette=COLORS, + showfliers=False, + width=0.72, + ax=ax, + ) + sns.stripplot( + data=plot, + x="stage_group", + y="beta", + hue="outcome", + hue_order=selected_outcomes, + dodge=True, + palette=COLORS, + size=2.7, + alpha=0.65, + linewidth=0, + legend=False, + ax=ax, + ) + ax.axhline(0, color="#666666", lw=0.8) + ax.set_xlabel("") + ax.set_ylabel("Scar-proximity coupling beta") + ax.set_title("B Fibrosis stage shifts the scar-coupled control balance", loc="left", fontweight="bold") + ax.legend(frameon=False, ncol=2, fontsize=8) + + ax = fig.add_subplot(grid[1, 2]) + dominance = coupling.loc[coupling["outcome"].eq("retention_dominance")].copy() + model = sm.OLS(dominance["beta"], sm.add_constant(dominance["stage_numeric"].astype(float))).fit() + line_x = np.linspace(0, 4, 100) + prediction = model.get_prediction(sm.add_constant(line_x)).summary_frame() + ax.plot(line_x, prediction["mean"], color=COLORS["retention_dominance"], lw=2) + ax.fill_between( + line_x, + prediction["mean_ci_lower"].to_numpy(float), + prediction["mean_ci_upper"].to_numpy(float), + color=COLORS["retention_dominance"], + alpha=0.15, + linewidth=0, + ) + offsets = {"F3a": -0.11, "F3b": 0.11} + rng = np.random.default_rng(20260711) + point_x = dominance["stage_numeric"].astype(float).to_numpy(copy=True) + point_x += dominance["fibrosis_stage"].astype(str).map(offsets).fillna(0).to_numpy(float) + point_x += rng.uniform(-0.035, 0.035, len(dominance)) + ax.scatter( + point_x, + dominance["beta"], + c=dominance["stage_group"].astype(str).map(stage_palette), + s=27, + linewidths=0, + alpha=0.9, + ) + trend = coupling_trends.set_index("outcome").loc["retention_dominance"] + ax.text( + 0.03, + 0.97, + f"array-adjusted beta={trend['stage_beta_array_adjusted']:.3f}\npermutation P={trend['stage_beta_within_array_permutation_p']:.3g}", + transform=ax.transAxes, + ha="left", + va="top", + fontsize=8, + ) + ax.axhline(0, color="#777777", lw=0.8) + ax.set_xticks([0, 1, 2, 3, 4], ["F0", "F1", "F2", "F3a / F3b", "F4"]) + ax.set_xlabel("Fibrosis stage") + ax.set_ylabel("Retention-dominance coupling") + ax.set_title("C Closing resolver window", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[2, :2]) + heat = coupling.pivot(index="biopsy_id", columns="outcome", values="beta") + annotation = coupling.drop_duplicates("biopsy_id").set_index("biopsy_id") + order = annotation.sort_values(["stage_numeric", "array"]).index + columns = ["HSC_retention", "Endo_resolver", "LAM_resolver", "retention_dominance", "AP1_control", "TGFb_integrator"] + heat = heat.loc[order, columns] + sns.heatmap(heat.T, cmap="vlag", center=0, robust=True, xticklabels=False, cbar_kws={"label": "Coupling beta"}, ax=ax) + boundaries = np.where(np.diff(annotation.loc[order, "stage_numeric"].to_numpy()) != 0)[0] + 1 + for boundary in boundaries: + ax.axvline(boundary, color="white", lw=1.5) + ax.set_xlabel("33 biopsies ordered by fibrosis stage") + ax.set_ylabel("") + ax.set_title("D Coordinated spatial control architecture", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[2, 2]) + pplot = coupling.loc[coupling["outcome"].isin(selected_outcomes)].copy() + summary = pplot.groupby(["stage_group", "outcome"], observed=True)["spatial_field_p"].apply(lambda x: (x < 0.05).mean()).reset_index(name="fraction") + summary["stage_group"] = pd.Categorical(summary["stage_group"], GROUP_ORDER, ordered=True) + sns.barplot(data=summary, x="stage_group", y="fraction", hue="outcome", hue_order=selected_outcomes, palette=COLORS, ax=ax) + ax.set_ylim(0, 1) + ax.set_xlabel("") + ax.set_ylabel("Fraction spatial-null P < 0.05") + ax.set_title("E Autocorrelation-preserving support", loc="left", fontweight="bold") + ax.legend(frameon=False, fontsize=7) + + for axis in fig.axes: + if hasattr(axis, "spines"): + axis.spines[["top", "right"]].set_visible(False) + fig.suptitle( + "Human MASLD progression shifts the scar niche from resolution toward stellate-cell retention", + fontsize=16, + fontweight="bold", + ) + fig.savefig(output.with_suffix(".png"), dpi=350, bbox_inches="tight", facecolor="white") + fig.savefig(output.with_suffix(".pdf"), bbox_inches="tight", facecolor="white") + plt.close(fig) + + +def main() -> None: + parser = argparse.ArgumentParser() + parser.add_argument("--visium-root", type=Path, required=True) + parser.add_argument("--component-map", type=Path, required=True) + parser.add_argument("--biopsy-map", type=Path, required=True) + parser.add_argument("--results-dir", type=Path, required=True) + parser.add_argument("--figures-dir", type=Path, required=True) + args = parser.parse_args() + args.results_dir.mkdir(parents=True, exist_ok=True) + args.figures_dir.mkdir(parents=True, exist_ok=True) + + mapping = pd.read_csv(args.biopsy_map, sep="\t") + mapping["fibrosis_stage"] = pd.Categorical(mapping["fibrosis_stage"], STAGE_ORDER, ordered=True) + mapping["stage_group"] = pd.Categorical(mapping["stage_group"], GROUP_ORDER, ordered=True) + expanded = explode_biopsy_map(mapping) + component_spots = pd.read_parquet(args.component_map) + frames = [] + audits = [] + module_mapping: dict[str, set[str]] = {name: set() for name in MODULES} + for array in mapping["array"].drop_duplicates(): + scores, mapped, audit = score_array(array, args.visium_root, component_spots, expanded) + frames.append(scores) + audits.append({"array": array, **audit}) + for module, genes in mapped.items(): + module_mapping[module].update(genes) + scored = pd.concat(frames, ignore_index=True) + data = add_scar_proximity(scored, 0.85) + coupling = fit_biopsies(data) + coupling_trends, mean_trends, biopsy_means = trend_tables(coupling, data) + + sensitivity_frames = [] + sensitivity_trends = [] + for scar_quantile in [0.80, 0.85, 0.90]: + local_data = data if scar_quantile == 0.85 else add_scar_proximity(scored, scar_quantile) + local_coupling = coupling if scar_quantile == 0.85 else fit_biopsies(local_data) + local_coupling = local_coupling.copy() + local_coupling["scar_quantile"] = scar_quantile + local_trends, _, _ = trend_tables(local_coupling, local_data) + local_trends["scar_quantile"] = scar_quantile + sensitivity_frames.append(local_coupling) + sensitivity_trends.append(local_trends) + + data.to_parquet(args.results_dir / "UQ_Visium_spot_module_scores.parquet", index=False) + coupling.to_csv(args.results_dir / "UQ_Visium_biopsy_spatial_coupling.tsv", sep="\t", index=False) + coupling_trends.to_csv(args.results_dir / "UQ_Visium_coupling_stage_trends.tsv", sep="\t", index=False) + pd.concat(sensitivity_frames, ignore_index=True).to_csv( + args.results_dir / "UQ_Visium_scar_threshold_sensitivity_coupling.tsv", sep="\t", index=False + ) + pd.concat(sensitivity_trends, ignore_index=True).to_csv( + args.results_dir / "UQ_Visium_scar_threshold_sensitivity_trends.tsv", sep="\t", index=False + ) + mean_trends.to_csv(args.results_dir / "UQ_Visium_module_mean_stage_trends.tsv", sep="\t", index=False) + biopsy_means.to_csv(args.results_dir / "UQ_Visium_biopsy_module_means.tsv", sep="\t", index=False) + pd.DataFrame(audits).to_csv(args.results_dir / "UQ_Visium_mapping_audit.tsv", sep="\t", index=False) + (args.results_dir / "UQ_Visium_module_gene_mapping.json").write_text( + json.dumps({name: sorted(genes) for name, genes in module_mapping.items()}, indent=2) + "\n" + ) + plot_main(data, coupling, coupling_trends, args.figures_dir / "Figure_UQ_MASLD_resolver_window_validation") + print("\nCOUPLING STAGE TRENDS\n", coupling_trends.to_string(index=False)) + print("\nMODULE-MEAN STAGE TRENDS\n", mean_trends.to_string(index=False)) + print("\nMAPPING AUDIT\n", pd.DataFrame(audits).to_string(index=False)) + + +if __name__ == "__main__": + main() diff --git a/code/spatial/UQ_biopsy_mapping_sensitivity.py b/code/spatial/UQ_biopsy_mapping_sensitivity.py new file mode 100644 index 0000000..27fd9d1 --- /dev/null +++ b/code/spatial/UQ_biopsy_mapping_sensitivity.py @@ -0,0 +1,568 @@ +#!/usr/bin/env python3 +"""Stress-test UQ biopsy registration without using expression scores to assign tissue.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import matplotlib as mpl +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +from scipy.stats import spearmanr +import statsmodels.formula.api as smf + +from spatial_domain_wall_resolver_window import graph_for_biopsy, largest_component + + +REPO_ROOT = Path(__file__).resolve().parents[2] +DEFAULT_SPOTS = ( + REPO_ROOT + / "data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spot_states.parquet" +) +DEFAULT_COMPONENT_MAP = ( + REPO_ROOT + / "data/UQ_spatial_mapping_derived/UQ_Visium_spot_component_map.parquet" +) +DEFAULT_BIOPSY_MAP = ( + REPO_ROOT + / "docs/methods_audit/machine_readable/UQ_Biopsy_Reconstruction_Map.tsv" +) +DEFAULT_OUTPUT = REPO_ROOT / "results/S15_UQ_biopsy_mapping_sensitivity" +SEED = 20260712 +METRICS = [ + "locked_fraction", + "largest_locked_domain_fraction", + "locked_domain_coherence", + "interface_edge_fraction", +] +KEY_METRICS = { + "largest_locked_domain_fraction": "Largest retention domain", + "interface_edge_fraction": "Resolver-retention interface", +} + + +def bh(values: pd.Series) -> np.ndarray: + p = values.to_numpy(float) + order = np.argsort(p) + adjusted = p[order] * len(p) / np.arange(1, len(p) + 1) + adjusted = np.minimum.accumulate(adjusted[::-1])[::-1] + result = np.empty_like(adjusted) + result[order] = np.clip(adjusted, 0, 1) + return result + + +def explode_biopsy_map(mapping: pd.DataFrame) -> pd.DataFrame: + rows: list[dict[str, object]] = [] + for record in mapping.to_dict("records"): + for component in str(record["component_members"]).split(","): + rows.append( + { + "array": record["array"], + "component": component.strip(), + "biopsy_id": record["biopsy_id"], + "fibrosis_stage": record["fibrosis_stage"], + "stage_numeric": float(record["stage_numeric"]), + "patient_cluster": record["patient_cluster"], + "mapping_source": record["mapping_source"], + } + ) + return pd.DataFrame(rows) + + +def audit_geometry( + spots: pd.DataFrame, + component_spots: pd.DataFrame, + expanded_map: pd.DataFrame, +) -> tuple[pd.DataFrame, pd.DataFrame]: + required = {"array", "barcode", "component"} + missing = required - set(component_spots.columns) + if missing: + raise ValueError(f"Component map is missing columns: {sorted(missing)}") + + geometry = component_spots[["array", "barcode", "component"]].rename( + columns={"component": "geometry_component"} + ) + audited = spots.merge(geometry, on=["array", "barcode"], how="left", validate="one_to_one") + audited["direct_geometry_component"] = audited["geometry_component"].notna() + audited["geometry_component_matches"] = ( + audited["geometry_component"].eq(audited["component"]) + & audited["direct_geometry_component"] + ) + audited["fragment_assignment"] = np.where( + audited["direct_geometry_component"], "direct_hex_component", "nearest_component_rescue" + ) + + expected = expanded_map.rename( + columns={ + "biopsy_id": "expected_biopsy_id", + "stage_numeric": "expected_stage_numeric", + "patient_cluster": "expected_patient_cluster", + } + ) + audited = audited.merge( + expected[ + [ + "array", + "component", + "expected_biopsy_id", + "expected_stage_numeric", + "expected_patient_cluster", + ] + ], + on=["array", "component"], + how="left", + validate="many_to_one", + ) + audited["registration_matches_table"] = ( + audited["biopsy_id"].eq(audited["expected_biopsy_id"]) + & audited["stage_numeric"].eq(audited["expected_stage_numeric"]) + & audited["patient_cluster"].eq(audited["expected_patient_cluster"]) + ) + + summaries: list[dict[str, object]] = [] + for array, local in audited.groupby("array", sort=True): + direct = local["direct_geometry_component"] + summaries.append( + { + "array": array, + "n_analysis_spots": int(len(local)), + "n_direct_geometry_spots": int(direct.sum()), + "n_rescued_fragment_spots": int((~direct).sum()), + "n_direct_component_matches": int(local.loc[direct, "geometry_component_matches"].sum()), + "direct_component_match_rate": float( + local.loc[direct, "geometry_component_matches"].mean() + ), + "n_registration_matches": int(local["registration_matches_table"].sum()), + "registration_match_rate": float(local["registration_matches_table"].mean()), + } + ) + return audited, pd.DataFrame(summaries) + + +def topology_for_units(spots: pd.DataFrame, unit_column: str) -> pd.DataFrame: + rows: list[dict[str, object]] = [] + for analysis_unit, source in spots.groupby(unit_column, sort=False, observed=True): + local = source.reset_index(drop=True).copy() + adjacency, pairs = graph_for_biopsy(local) + state = local["p_locked"].to_numpy(float) >= 0.5 + locked_n = int(state.sum()) + largest = largest_component(state, adjacency) + cross_edges = int(sum(state[i] != state[j] for i, j in pairs)) + rows.append( + { + "analysis_unit": analysis_unit, + "biopsy_id": local["biopsy_id"].iloc[0], + "component": local["component"].iloc[0] + if local["component"].nunique() == 1 + else "MULTI", + "array": local["array"].iloc[0], + "patient_cluster": local["patient_cluster"].iloc[0], + "stage_numeric": float(local["stage_numeric"].iloc[0]), + "n_spots": int(len(local)), + "locked_fraction": locked_n / len(local), + "largest_locked_domain_fraction": largest / len(local), + "locked_domain_coherence": largest / max(locked_n, 1), + "interface_edge_fraction": cross_edges / max(len(pairs), 1), + "n_graph_edges": int(len(pairs)), + } + ) + return pd.DataFrame(rows) + + +def fit_trends(topology: pd.DataFrame, n_perm: int) -> pd.DataFrame: + rng = np.random.default_rng(SEED) + groups = [ + np.asarray(list(index), dtype=int) + for index in topology.groupby("array", sort=False).groups.values() + ] + stage = topology["stage_numeric"].to_numpy(float) + stage_centered = stage.copy() + for index in groups: + stage_centered[index] -= stage_centered[index].mean() + + rows: list[dict[str, object]] = [] + for metric in METRICS: + model = smf.ols(f"{metric} ~ stage_numeric + C(array)", data=topology) + hc3 = model.fit(cov_type="HC3") + clustered = model.fit( + cov_type="cluster", + cov_kwds={"groups": topology["patient_cluster"].to_numpy()}, + ) + observed = float(hc3.params["stage_numeric"]) + outcome_centered = topology[metric].to_numpy(float).copy() + for index in groups: + outcome_centered[index] -= outcome_centered[index].mean() + denominator = np.dot(stage_centered, stage_centered) + null = np.empty(n_perm) + for permutation in range(n_perm): + permuted = stage_centered.copy() + for positions in groups: + permuted[positions] = rng.permutation(permuted[positions]) + null[permutation] = np.dot(permuted, outcome_centered) / denominator + permutation_p = (1 + np.sum(np.abs(null) >= abs(observed))) / (n_perm + 1) + rho, spearman_p = spearmanr(topology["stage_numeric"], topology[metric]) + rows.append( + { + "metric": metric, + "n_units": int(len(topology)), + "n_biopsies": int(topology["biopsy_id"].nunique()), + "n_patients": int(topology["patient_cluster"].nunique()), + "n_arrays": int(topology["array"].nunique()), + "stage_beta_array_adjusted": observed, + "stage_beta_se_hc3": float(hc3.bse["stage_numeric"]), + "hc3_p_value": float(hc3.pvalues["stage_numeric"]), + "patient_cluster_p_value": float(clustered.pvalues["stage_numeric"]), + "within_array_permutation_p": float(permutation_p), + "spearman_rho": float(rho), + "spearman_p_value": float(spearman_p), + } + ) + result = pd.DataFrame(rows) + result["permutation_fdr"] = bh(result["within_array_permutation_p"]) + return result + + +def build_scenarios( + audited: pd.DataFrame, + mapping: pd.DataFrame, +) -> list[tuple[str, pd.DataFrame, str]]: + data = audited.copy() + data["component_unit"] = data["array"] + "_" + data["component"] + multi_biopsies = set( + mapping.loc[mapping["component_members"].str.contains(",", regex=False), "biopsy_id"] + ) + inferred = set( + mapping.loc[ + mapping["mapping_source"].str.contains("inferred", case=False, na=False), + "biopsy_id", + ] + ) + return [ + ("registered_biopsy_all", data, "biopsy_id"), + ( + "registered_biopsy_no_fragment_rescue", + data.loc[data["direct_geometry_component"]].copy(), + "biopsy_id", + ), + ("geometry_component_split_all", data, "component_unit"), + ( + "geometry_component_split_no_fragment_rescue", + data.loc[data["direct_geometry_component"]].copy(), + "component_unit", + ), + ( + "exclude_inferred_synchronous_pair", + data.loc[~data["biopsy_id"].isin(inferred)].copy(), + "biopsy_id", + ), + ( + "exclude_all_multicomponent_biopsies", + data.loc[~data["biopsy_id"].isin(multi_biopsies)].copy(), + "biopsy_id", + ), + ] + + +def leave_one_array_out(audited: pd.DataFrame, n_perm: int) -> pd.DataFrame: + frames: list[pd.DataFrame] = [] + for array in sorted(audited["array"].unique()): + subset = audited.loc[~audited["array"].eq(array)].copy() + topology = topology_for_units(subset, "biopsy_id") + trends = fit_trends(topology, n_perm=n_perm) + trends.insert(0, "scenario", f"leave_out_{array}") + trends.insert(1, "excluded_array", array) + frames.append(trends) + return pd.concat(frames, ignore_index=True) + + +def plot_key_results( + scenario_trends: pd.DataFrame, + leave_one_out: pd.DataFrame, + geometry_summary: pd.DataFrame, + output: Path, +) -> None: + mpl.rcParams["svg.fonttype"] = "none" + mpl.rcParams["font.family"] = "Arial" + fig = plt.figure(figsize=(12.8, 8.3), facecolor="white") + grid = fig.add_gridspec(2, 2, hspace=0.46, wspace=0.44) + + ax = fig.add_subplot(grid[0, :]) + x = np.arange(len(geometry_summary)) + direct = geometry_summary["n_direct_geometry_spots"].to_numpy() + rescued = geometry_summary["n_rescued_fragment_spots"].to_numpy() + ax.bar(x, direct, color="#2D8FB3", label="Direct hex component") + ax.bar(x, rescued, bottom=direct, color="#D8AD55", label="Nearest-component rescue") + ax.set_xticks(x, geometry_summary["array"], rotation=25, ha="right") + ax.set_ylabel("Analysis spots") + ax.set_title("A Geometry-only component recovery", loc="left", fontweight="bold") + ax.legend(frameon=False, ncol=2, loc="upper left") + + scenario_order = [ + "registered_biopsy_all", + "registered_biopsy_no_fragment_rescue", + "geometry_component_split_all", + "geometry_component_split_no_fragment_rescue", + "exclude_inferred_synchronous_pair", + "exclude_all_multicomponent_biopsies", + ] + labels = { + "registered_biopsy_all": "Registered biopsies", + "registered_biopsy_no_fragment_rescue": "No rescued fragments", + "geometry_component_split_all": "Split geometric components", + "geometry_component_split_no_fragment_rescue": "Split + no rescue", + "exclude_inferred_synchronous_pair": "Exclude sync pair", + "exclude_all_multicomponent_biopsies": "Exclude merged cores", + } + colors = { + "largest_locked_domain_fraction": "#A93651", + "interface_edge_fraction": "#2D8FB3", + } + for panel, metric in enumerate(KEY_METRICS, start=1): + ax = fig.add_subplot(grid[1, panel - 1]) + current = ( + scenario_trends.loc[scenario_trends["metric"].eq(metric)] + .set_index("scenario") + .loc[scenario_order] + .reset_index() + ) + y = np.arange(len(current))[::-1] + beta = current["stage_beta_array_adjusted"].to_numpy() + se = current["stage_beta_se_hc3"].to_numpy() + ax.errorbar( + beta, + y, + xerr=1.96 * se, + fmt="o", + color=colors[metric], + ecolor=colors[metric], + capsize=2.5, + lw=1.4, + ) + loo = leave_one_out.loc[leave_one_out["metric"].eq(metric), "stage_beta_array_adjusted"] + ax.axvspan(loo.min(), loo.max(), color=colors[metric], alpha=0.10, lw=0) + ax.axvline(0, color="#59636A", lw=0.8) + ax.set_yticks(y, [labels[name] for name in current["scenario"]]) + ax.set_xlabel("Array-adjusted stage effect (95% HC3 CI)") + ax.set_title( + f"{chr(65 + panel)} {KEY_METRICS[metric]}", + loc="left", + fontweight="bold", + ) + + for axis in fig.axes: + axis.spines[["top", "right"]].set_visible(False) + fig.suptitle( + "Spatial retention-domain conclusions survive biopsy-registration stress tests", + fontsize=15, + fontweight="bold", + y=0.98, + ) + fig.savefig(output / "UQ_biopsy_mapping_sensitivity.svg", bbox_inches="tight") + fig.savefig(output / "UQ_biopsy_mapping_sensitivity.pdf", bbox_inches="tight") + fig.savefig(output / "UQ_biopsy_mapping_sensitivity.png", dpi=320, bbox_inches="tight") + plt.close(fig) + + +def make_report( + geometry_summary: pd.DataFrame, + scenario_trends: pd.DataFrame, + leave_one_out: pd.DataFrame, + mapping: pd.DataFrame, +) -> tuple[dict[str, object], str]: + key = scenario_trends.loc[scenario_trends["metric"].isin(KEY_METRICS)].copy() + expected = key["metric"].map( + { + "largest_locked_domain_fraction": 1, + "interface_edge_fraction": -1, + } + ) + key["expected_direction"] = np.sign(key["stage_beta_array_adjusted"]).eq(expected) + loo_key = leave_one_out.loc[leave_one_out["metric"].isin(KEY_METRICS)].copy() + loo_expected = loo_key["metric"].map( + { + "largest_locked_domain_fraction": 1, + "interface_edge_fraction": -1, + } + ) + loo_key["expected_direction"] = np.sign( + loo_key["stage_beta_array_adjusted"] + ).eq(loo_expected) + + direct = int(geometry_summary["n_direct_geometry_spots"].sum()) + rescued = int(geometry_summary["n_rescued_fragment_spots"].sum()) + direct_matches = int(geometry_summary["n_direct_component_matches"].sum()) + registered_matches = int(geometry_summary["n_registration_matches"].sum()) + total = int(geometry_summary["n_analysis_spots"].sum()) + summary = { + "analysis_scope": "UQ MASLD Visium biopsy reconstruction and spatial topology", + "geometry_assignment_inputs": [ + "array identifier", + "Visium barcode", + "hex-grid array_row and array_col", + "connected-component membership", + ], + "scores_excluded_from_assignment": [ + "ECM_scar", + "HSC_retention", + "Endo_resolver", + "LAM_resolver", + "repair/resolver composite scores", + "p_locked", + ], + "direct_geometry_spots": direct, + "nearest_component_rescue_spots": rescued, + "direct_geometry_match_rate": direct_matches / max(direct, 1), + "registration_table_match_rate": registered_matches / max(total, 1), + "registered_biopsies": int(mapping["biopsy_id"].nunique()), + "patient_clusters": int(mapping["patient_cluster"].nunique()), + "multicomponent_biopsies": int( + mapping["component_members"].str.contains(",", regex=False).sum() + ), + "inferred_synchronous_biopsies": int( + mapping["mapping_source"].str.contains("inferred", case=False, na=False).sum() + ), + "scenario_key_direction_pass": int(key["expected_direction"].sum()), + "scenario_key_direction_total": int(len(key)), + "leave_one_array_out_key_direction_pass": int(loo_key["expected_direction"].sum()), + "leave_one_array_out_key_direction_total": int(len(loo_key)), + "historical_operator_blinding": "not documented", + "independent_reconstruction_conclusion": ( + "The current geometry-only audit reproduces component membership without consulting " + "ECM, retention, resolver, repair, or fitted-state scores. Historical strict operator " + "blinding cannot be established from the archived record." + ), + } + + primary = ( + scenario_trends.loc[ + scenario_trends["scenario"].eq("registered_biopsy_all") + & scenario_trends["metric"].isin(KEY_METRICS) + ] + .set_index("metric") + ) + split = ( + scenario_trends.loc[ + scenario_trends["scenario"].eq("geometry_component_split_no_fragment_rescue") + & scenario_trends["metric"].isin(KEY_METRICS) + ] + .set_index("metric") + ) + report = f"""# UQ biopsy reconstruction and mapping sensitivity audit + +## Decision + +The spatial-retention result is robust to the principal reconstruction choices tested here. The largest retention-domain effect and interface-compression effect retained their expected directions in {summary['scenario_key_direction_pass']}/{summary['scenario_key_direction_total']} prespecified mapping scenarios and {summary['leave_one_array_out_key_direction_pass']}/{summary['leave_one_array_out_key_direction_total']} leave-one-array-out tests. + +## Score-independent reconstruction + +The audit recovered {direct:,} spots directly from Visium hex-grid connected components. All directly recovered spots matched their archived component labels ({summary['direct_geometry_match_rate']:.3%}). A further {rescued:,} spots belonged to small disconnected fragments and had previously been assigned to the nearest registered component. Removing those rescued spots did not reverse either key result. Component construction and registration checking used array identity, barcodes, spatial coordinates, and the archived biopsy table. ECM, HSC-retention, endothelial/macrophage resolver, repair, and fitted-state scores were excluded from assignment. + +The archived map contains {summary['multicomponent_biopsies']} biopsies assembled from more than one geometric component and {summary['inferred_synchronous_biopsies']} biopsy entries from one inferred synchronous pair. Splitting every component into its own analysis unit, excluding all multicomponent biopsies, and excluding the inferred pair each preserved the key effect directions. + +## Key estimates + +Registered-biopsy analysis: + +- Largest retention domain per stage: beta = {primary.loc['largest_locked_domain_fraction', 'stage_beta_array_adjusted']:.4f}; within-array permutation q = {primary.loc['largest_locked_domain_fraction', 'permutation_fdr']:.4g}. +- Resolver-retention interface per stage: beta = {primary.loc['interface_edge_fraction', 'stage_beta_array_adjusted']:.4f}; within-array permutation q = {primary.loc['interface_edge_fraction', 'permutation_fdr']:.4g}. + +Geometry-component analysis with rescued fragments removed: + +- Largest retention domain per stage: beta = {split.loc['largest_locked_domain_fraction', 'stage_beta_array_adjusted']:.4f}; within-array permutation q = {split.loc['largest_locked_domain_fraction', 'permutation_fdr']:.4g}. +- Resolver-retention interface per stage: beta = {split.loc['interface_edge_fraction', 'stage_beta_array_adjusted']:.4f}; within-array permutation q = {split.loc['interface_edge_fraction', 'permutation_fdr']:.4g}. + +## Audit boundary + +The independent computational reconstruction is score-blind by construction. The original operator's strict blinding to ECM, retention, and repair scores is not documented in the historical archive. The defensible manuscript wording is that the reconstruction table predates score generation and that an independent score-excluded reconstruction plus mapping sensitivity analysis reproduced the conclusions. The original per-spot `*_samples.csv` files referenced by the source study code are not present in the local archive and remain the only unresolved provenance item. +""" + return summary, report + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--phase-spots", type=Path, default=DEFAULT_SPOTS) + parser.add_argument("--component-map", type=Path, default=DEFAULT_COMPONENT_MAP) + parser.add_argument("--biopsy-map", type=Path, default=DEFAULT_BIOPSY_MAP) + parser.add_argument("--output-dir", type=Path, default=DEFAULT_OUTPUT) + parser.add_argument("--permutations", type=int, default=9999) + parser.add_argument("--loo-permutations", type=int, default=1999) + return parser.parse_args() + + +def main() -> None: + args = parse_args() + args.output_dir.mkdir(parents=True, exist_ok=True) + spots = pd.read_parquet(args.phase_spots) + component_spots = pd.read_parquet(args.component_map) + mapping = pd.read_csv(args.biopsy_map, sep="\t") + expanded_map = explode_biopsy_map(mapping) + + audited, geometry_summary = audit_geometry(spots, component_spots, expanded_map) + audit_columns = [ + "array", + "barcode", + "array_row", + "array_col", + "pxl_row_in_fullres", + "pxl_col_in_fullres", + "component", + "geometry_component", + "direct_geometry_component", + "geometry_component_matches", + "fragment_assignment", + "biopsy_id", + "fibrosis_stage", + "stage_numeric", + "patient_cluster", + "mapping_source", + "expected_biopsy_id", + "expected_stage_numeric", + "expected_patient_cluster", + "registration_matches_table", + ] + audited[audit_columns].to_parquet( + args.output_dir / "UQ_spot_geometry_registration_audit.parquet", index=False + ) + geometry_summary.to_csv( + args.output_dir / "UQ_geometry_reconstruction_summary.tsv", sep="\t", index=False + ) + + topology_frames: list[pd.DataFrame] = [] + trend_frames: list[pd.DataFrame] = [] + for name, scenario_spots, unit_column in build_scenarios(audited, mapping): + topology = topology_for_units(scenario_spots, unit_column) + topology.insert(0, "scenario", name) + trends = fit_trends(topology, n_perm=args.permutations) + trends.insert(0, "scenario", name) + topology_frames.append(topology) + trend_frames.append(trends) + scenario_topology = pd.concat(topology_frames, ignore_index=True) + scenario_trends = pd.concat(trend_frames, ignore_index=True) + scenario_topology.to_csv( + args.output_dir / "UQ_mapping_scenario_topology.tsv", sep="\t", index=False + ) + scenario_trends.to_csv( + args.output_dir / "UQ_mapping_scenario_stage_trends.tsv", sep="\t", index=False + ) + + leave_one_out = leave_one_array_out(audited, n_perm=args.loo_permutations) + leave_one_out.to_csv( + args.output_dir / "UQ_mapping_leave_one_array_out.tsv", sep="\t", index=False + ) + plot_key_results(scenario_trends, leave_one_out, geometry_summary, args.output_dir) + + summary, report = make_report(geometry_summary, scenario_trends, leave_one_out, mapping) + (args.output_dir / "UQ_biopsy_mapping_sensitivity_summary.json").write_text( + json.dumps(summary, indent=2) + "\n", encoding="utf-8" + ) + (args.output_dir / "UQ_BIOPSY_MAPPING_AUDIT.md").write_text( + report, encoding="utf-8" + ) + print(json.dumps(summary, indent=2)) + + +if __name__ == "__main__": + main() diff --git a/code/spatial/spatial_domain_wall_resolver_window.py b/code/spatial/spatial_domain_wall_resolver_window.py new file mode 100644 index 0000000..1ddd10f --- /dev/null +++ b/code/spatial/spatial_domain_wall_resolver_window.py @@ -0,0 +1,496 @@ +#!/usr/bin/env python3 +"""Test whether locked spatial domains coalesce as the resolver window closes.""" + +from __future__ import annotations + +import argparse +from collections import deque +import json +from pathlib import Path + +import matplotlib.pyplot as plt +from matplotlib.colors import LinearSegmentedColormap +import numpy as np +import pandas as pd +import seaborn as sns +from scipy.spatial import cKDTree +from scipy.stats import spearmanr, wilcoxon +import statsmodels.formula.api as smf + + +REPO_ROOT = Path(__file__).resolve().parents[2] +INPUT = REPO_ROOT / "data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spot_states.parquet" +OUTPUT = REPO_ROOT / "results/S14_spatial_retention_domains" +SEED = 20260712 + +COLORS = { + "Endothelial resolver": "#2D8FB3", + "Macrophage resolver": "#58A47A", + "Protease activation": "#7D71B3", + "Antiproteolytic brake": "#D18F24", + "HSC retention": "#C43D55", + "TGF-beta integrator": "#8D5A4A", + "Structural ECM": "#3F4548", +} + +FEATURES = { + "Endothelial resolver": "adj_Endo_resolver", + "Macrophage resolver": "adj_LAM_resolver", + "Protease activation": "adj_protease_activation_potential", + "Antiproteolytic brake": "adj_antiproteolytic_brake", + "HSC retention": "adj_HSC_retention", + "TGF-beta integrator": "adj_TGFb_integrator", + "Structural ECM": "structural_ECM_scar", +} + + +def bh(values: pd.Series) -> np.ndarray: + p = values.to_numpy(float) + order = np.argsort(p) + ranked = p[order] * len(p) / np.arange(1, len(p) + 1) + ranked = np.minimum.accumulate(ranked[::-1])[::-1] + result = np.empty_like(ranked) + result[order] = np.clip(ranked, 0, 1) + return result + + +def graph_for_biopsy(local: pd.DataFrame) -> tuple[list[list[int]], list[tuple[int, int]]]: + xy = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + tree = cKDTree(xy) + nearest = tree.query(xy, k=2)[0][:, 1] + radius = float(np.median(nearest) * 1.25) + pairs = sorted(tree.query_pairs(radius)) + adjacency = [[] for _ in range(len(local))] + for i, j in pairs: + adjacency[i].append(j) + adjacency[j].append(i) + return adjacency, pairs + + +def signed_domain_distance(state: np.ndarray, adjacency: list[list[int]]) -> tuple[np.ndarray, np.ndarray]: + distance = np.full(len(state), 10_000, dtype=int) + boundary = np.zeros(len(state), dtype=bool) + queue: deque[int] = deque() + for i, neighbors in enumerate(adjacency): + if any(state[j] != state[i] for j in neighbors): + distance[i] = 1 + boundary[i] = True + queue.append(i) + while queue: + i = queue.popleft() + for j in adjacency[i]: + if state[j] == state[i] and distance[j] > distance[i] + 1: + distance[j] = distance[i] + 1 + queue.append(j) + finite = distance < 10_000 + if not finite.all(): + distance[~finite] = 7 + signed = np.minimum(distance, 7) * np.where(state, 1, -1) + return signed, boundary + + +def largest_component(state: np.ndarray, adjacency: list[list[int]]) -> int: + seen: set[int] = set() + sizes: list[int] = [] + for start in np.flatnonzero(state): + if int(start) in seen: + continue + stack = [int(start)] + seen.add(int(start)) + size = 0 + while stack: + node = stack.pop() + size += 1 + for neighbor in adjacency[node]: + if state[neighbor] and neighbor not in seen: + seen.add(neighbor) + stack.append(neighbor) + sizes.append(size) + return max(sizes, default=0) + + +def build_front_data(spots: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + annotated = [] + topology = [] + for biopsy_id, source in spots.groupby("biopsy_id", sort=False): + local = source.reset_index(drop=True).copy() + adjacency, pairs = graph_for_biopsy(local) + state = local.p_locked.to_numpy(float) >= 0.5 + signed, boundary = signed_domain_distance(state, adjacency) + local["locked_binary"] = state + local["signed_domain_distance"] = signed + local["domain_boundary"] = boundary + annotated.append(local) + + locked_n = int(state.sum()) + largest = largest_component(state, adjacency) + cross_edges = int(sum(state[i] != state[j] for i, j in pairs)) + topology.append( + { + "biopsy_id": biopsy_id, + "array": local["array"].iloc[0], + "patient_cluster": local.patient_cluster.iloc[0], + "stage_numeric": float(local.stage_numeric.iloc[0]), + "stage_group": local.stage_group.iloc[0], + "n_spots": int(len(local)), + "locked_fraction": locked_n / len(local), + "largest_locked_domain_fraction": largest / len(local), + "locked_domain_coherence": largest / max(locked_n, 1), + "interface_edge_fraction": cross_edges / max(len(pairs), 1), + "n_graph_edges": int(len(pairs)), + } + ) + return pd.concat(annotated, ignore_index=True), pd.DataFrame(topology) + + +def biopsy_profiles(front: pd.DataFrame) -> pd.DataFrame: + distances = [-4, -3, -2, -1, 1, 2, 3, 4] + rows = [] + for (biopsy_id, distance), local in front.loc[ + front.signed_domain_distance.isin(distances) + ].groupby(["biopsy_id", "signed_domain_distance"], observed=True): + row = { + "biopsy_id": biopsy_id, + "patient_cluster": local.patient_cluster.iloc[0], + "stage_numeric": float(local.stage_numeric.iloc[0]), + "distance": int(distance), + "n_spots": int(len(local)), + } + for label, feature in FEATURES.items(): + row[label] = float(local[feature].mean()) + resolver = local[[ + FEATURES["Endothelial resolver"], + FEATURES["Macrophage resolver"], + FEATURES["Protease activation"], + ]].mean(axis=1) + lock = local[[ + FEATURES["Antiproteolytic brake"], + FEATURES["HSC retention"], + FEATURES["TGF-beta integrator"], + ]].mean(axis=1) + row["resolver_advantage"] = float((resolver - lock).mean()) + rows.append(row) + return pd.DataFrame(rows) + + +def clustered_bootstrap(values: pd.DataFrame, column: str, n_boot: int = 4000) -> tuple[float, float]: + rng = np.random.default_rng(SEED) + cluster_stats = values.groupby("patient_cluster")[column].agg(["sum", "count"]) + sums = cluster_stats["sum"].to_numpy(float) + counts = cluster_stats["count"].to_numpy(float) + sampled = rng.integers(0, len(cluster_stats), size=(n_boot, len(cluster_stats))) + estimates = sums[sampled].sum(axis=1) / counts[sampled].sum(axis=1) + return tuple(np.quantile(estimates, [0.025, 0.975])) + + +def boundary_effects(front: pd.DataFrame) -> pd.DataFrame: + rows = [] + for biopsy_id, local in front.groupby("biopsy_id", sort=False): + resolved = local.signed_domain_distance.isin([-2, -1]) + locked = local.signed_domain_distance.isin([1, 2]) + if not resolved.any() or not locked.any(): + continue + base = { + "biopsy_id": biopsy_id, + "patient_cluster": local.patient_cluster.iloc[0], + "stage_numeric": float(local.stage_numeric.iloc[0]), + } + for label, feature in FEATURES.items(): + rows.append( + { + **base, + "module": label, + "locked_minus_resolved": float(local.loc[locked, feature].mean() - local.loc[resolved, feature].mean()), + } + ) + effects = pd.DataFrame(rows) + summaries = [] + for module, local in effects.groupby("module", sort=False): + statistic, p_value = wilcoxon(local.locked_minus_resolved, alternative="two-sided") + low, high = clustered_bootstrap(local, "locked_minus_resolved") + summaries.append( + { + "module": module, + "n_biopsies": int(local.biopsy_id.nunique()), + "mean_shift": float(local.locked_minus_resolved.mean()), + "median_shift": float(local.locked_minus_resolved.median()), + "bootstrap_ci_low": float(low), + "bootstrap_ci_high": float(high), + "wilcoxon_statistic": float(statistic), + "p_value": float(p_value), + } + ) + summary = pd.DataFrame(summaries) + summary["fdr"] = bh(summary.p_value) + return effects.merge(summary[["module", "fdr"]], on="module", how="left"), summary + + +def topology_trends(topology: pd.DataFrame, n_perm: int = 10_000) -> pd.DataFrame: + rng = np.random.default_rng(SEED) + metrics = [ + "locked_fraction", + "largest_locked_domain_fraction", + "locked_domain_coherence", + "interface_edge_fraction", + ] + rows = [] + groups = [np.asarray(list(index), dtype=int) for index in topology.groupby("array").groups.values()] + stage = topology.stage_numeric.to_numpy(float) + stage_centered = stage.copy() + for index in groups: + stage_centered[index] -= stage_centered[index].mean() + for metric in metrics: + fit = smf.ols(f"{metric} ~ stage_numeric + C(array)", data=topology).fit(cov_type="HC3") + observed = float(fit.params["stage_numeric"]) + outcome_centered = topology[metric].to_numpy(float).copy() + for index in groups: + outcome_centered[index] -= outcome_centered[index].mean() + null = np.empty(n_perm) + for index in range(n_perm): + permuted = stage_centered.copy() + for positions in groups: + permuted[positions] = rng.permutation(permuted[positions]) + null[index] = np.dot(permuted, outcome_centered) / np.dot(permuted, permuted) + permutation_p = (1 + np.sum(np.abs(null) >= abs(observed))) / (n_perm + 1) + rho, spearman_p = spearmanr(topology.stage_numeric, topology[metric]) + rows.append( + { + "metric": metric, + "stage_beta_array_adjusted": observed, + "hc3_p_value": float(fit.pvalues["stage_numeric"]), + "within_array_permutation_p": float(permutation_p), + "spearman_rho": float(rho), + "spearman_p_value": float(spearman_p), + } + ) + trends = pd.DataFrame(rows) + trends["permutation_fdr"] = bh(trends.within_array_permutation_p) + return trends + + +def threshold_sensitivity(spots: pd.DataFrame) -> pd.DataFrame: + rows = [] + for threshold in [0.40, 0.50, 0.60, 0.67]: + metrics = [] + for biopsy_id, source in spots.groupby("biopsy_id", sort=False): + local = source.reset_index(drop=True) + adjacency, pairs = graph_for_biopsy(local) + state = local.p_locked.to_numpy(float) >= threshold + largest = largest_component(state, adjacency) + metrics.append( + { + "biopsy_id": biopsy_id, + "array": local["array"].iloc[0], + "stage_numeric": float(local.stage_numeric.iloc[0]), + "largest_locked_domain_fraction": largest / len(local), + "interface_edge_fraction": sum(state[i] != state[j] for i, j in pairs) / max(len(pairs), 1), + } + ) + local_metrics = pd.DataFrame(metrics) + for metric in ["largest_locked_domain_fraction", "interface_edge_fraction"]: + fit = smf.ols(f"{metric} ~ stage_numeric + C(array)", data=local_metrics).fit(cov_type="HC3") + rows.append( + { + "p_locked_threshold": threshold, + "metric": metric, + "stage_beta_array_adjusted": float(fit.params["stage_numeric"]), + "hc3_p_value": float(fit.pvalues["stage_numeric"]), + } + ) + result = pd.DataFrame(rows) + result["hc3_fdr"] = bh(result.hc3_p_value) + return result + + +def profile_summary(profiles: pd.DataFrame) -> pd.DataFrame: + rows = [] + columns = [*FEATURES.keys(), "resolver_advantage"] + for distance, local in profiles.groupby("distance"): + for column in columns: + low, high = clustered_bootstrap(local, column, n_boot=2500) + rows.append( + { + "distance": int(distance), + "module": column, + "mean": float(local[column].mean()), + "ci_low": float(low), + "ci_high": float(high), + "n_biopsies": int(local.biopsy_id.nunique()), + } + ) + return pd.DataFrame(rows) + + +def plot_results( + front: pd.DataFrame, + topology: pd.DataFrame, + profile_stats: pd.DataFrame, + effect_summary: pd.DataFrame, + trends: pd.DataFrame, +) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(17.5, 11.5), facecolor="white") + grid = fig.add_gridspec(2, 3, left=.09, right=.985, bottom=.065, top=.91, wspace=.34, hspace=.37) + + mixed = front.groupby("biopsy_id").agg(n=("barcode", "size"), locked=("locked_binary", "mean")) + representative = (mixed.n * 4 * mixed.locked * (1 - mixed.locked)).idxmax() + local = front.loc[front.biopsy_id.eq(representative)].copy() + ax = fig.add_subplot(grid[0, 0]) + cmap = LinearSegmentedColormap.from_list("basin", ["#2A9D8F", "#E5B84B", "#C43D55"]) + ax.scatter( + local.pxl_col_in_fullres, + -local.pxl_row_in_fullres, + c=local.p_locked, + cmap=cmap, + vmin=0, + vmax=1, + s=16, + linewidth=0, + ) + wall = local.loc[local.domain_boundary] + ax.scatter( + wall.pxl_col_in_fullres, + -wall.pxl_row_in_fullres, + facecolors="none", + edgecolors="#222222", + linewidth=.45, + s=27, + ) + ax.set_aspect("equal") + ax.set_axis_off() + ax.set_title(f"A A resolved-to-locked domain wall ({representative})", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[0, 1]) + modules = ["Endothelial resolver", "Macrophage resolver", "Antiproteolytic brake", "HSC retention", "Structural ECM"] + for module in modules: + plot = profile_stats.loc[profile_stats.module.eq(module) & profile_stats.n_biopsies.ge(8)].sort_values("distance") + ax.plot(plot.distance, plot["mean"], marker="o", ms=3.5, lw=1.8, color=COLORS[module], label=module) + ax.fill_between(plot.distance, plot.ci_low, plot.ci_high, color=COLORS[module], alpha=.12, linewidth=0) + ax.axvline(0, color="#59636A", ls="--", lw=1) + ax.set(xlabel="Signed graph distance from separatrix", ylabel="Array-adjusted module activity") + ax.set_title("B State programs align across the separatrix", loc="left", fontweight="bold") + ax.legend(frameon=False, fontsize=7, ncol=2, loc="upper left") + + ax = fig.add_subplot(grid[0, 2]) + advantage = profile_stats.loc[ + profile_stats.module.eq("resolver_advantage") & profile_stats.n_biopsies.ge(8) + ].sort_values("distance") + ax.plot(advantage.distance, advantage["mean"], color="#3A6670", marker="o", lw=2.3) + ax.fill_between(advantage.distance, advantage.ci_low, advantage.ci_high, color="#3A6670", alpha=.18, linewidth=0) + ax.axhline(0, color="#444", lw=.8) + ax.axvline(0, color="#59636A", ls="--", lw=1) + ax.fill_between([-4, 0], -1.2, 1.2, color="#2A9D8F", alpha=.06) + ax.fill_between([0, 4], -1.2, 1.2, color="#C43D55", alpha=.06) + ax.text(-3.8, .95, "resolver window open", color="#287D72", fontsize=8) + ax.text(.2, .95, "lock exceeds resolver", color="#A52E46", fontsize=8) + ax.set(xlabel="Signed graph distance from separatrix", ylabel="Resolver advantage") + ax.set_ylim(-1.15, 1.1) + ax.set_title("C The resolver window closes inside the locked domain", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 0]) + order = effect_summary.sort_values("mean_shift").reset_index(drop=True) + y = np.arange(len(order)) + for index, row in order.iterrows(): + ax.plot([row.bootstrap_ci_low, row.bootstrap_ci_high], [index, index], color=COLORS[row.module], lw=2) + ax.scatter(row.mean_shift, index, color=COLORS[row.module], s=42, edgecolor="white", linewidth=.5, zorder=3) + ax.text(row.bootstrap_ci_high + .012, index, f"q={row.fdr:.2g}", va="center", fontsize=7, color="#4D5559") + labels = [row.module for row in order.itertuples()] + ax.set_yticks(y, labels) + ax.axvline(0, color="#555", lw=.8) + ax.set_xlim(-.03, .58) + ax.set_xlabel("Locked minus resolved boundary activity") + ax.set_title("D State alignment across 33 biopsies", loc="left", fontweight="bold") + + stage_palette = {0: "#87B7A7", 1: "#68A7A0", 2: "#D8AD55", 3: "#C36C64", 4: "#A93651"} + ax = fig.add_subplot(grid[1, 1]) + rng = np.random.default_rng(SEED) + for stage, local_stage in topology.groupby("stage_numeric"): + x = stage + rng.normal(0, .045, len(local_stage)) + ax.scatter(x, local_stage.largest_locked_domain_fraction, color=stage_palette[int(stage)], s=38, edgecolor="white", linewidth=.5) + sns.regplot(data=topology, x="stage_numeric", y="largest_locked_domain_fraction", scatter=False, color="#5A3740", ci=95, ax=ax) + trend = trends.set_index("metric").loc["largest_locked_domain_fraction"] + ax.text(.03, .96, f"array-adjusted beta={trend.stage_beta_array_adjusted:.3f}\npermutation q={trend.permutation_fdr:.3g}", transform=ax.transAxes, va="top", fontsize=8) + ax.set(xlabel="Fibrosis stage", ylabel="Largest locked domain / biopsy") + ax.set_title("E Locked islands coalesce into a dominant domain", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 2]) + for stage, local_stage in topology.groupby("stage_numeric"): + x = stage + rng.normal(0, .045, len(local_stage)) + ax.scatter(x, local_stage.interface_edge_fraction, color=stage_palette[int(stage)], s=38, edgecolor="white", linewidth=.5) + sns.regplot(data=topology, x="stage_numeric", y="interface_edge_fraction", scatter=False, color="#3A6670", ci=95, ax=ax) + trend = trends.set_index("metric").loc["interface_edge_fraction"] + ax.text(.03, .96, f"array-adjusted beta={trend.stage_beta_array_adjusted:.3f}\npermutation q={trend.permutation_fdr:.3g}", transform=ax.transAxes, va="top", fontsize=8) + ax.set(xlabel="Fibrosis stage", ylabel="Resolved-locked interface / graph edges") + ax.set_title("F Interface compression marks spatial lock-in", loc="left", fontweight="bold") + + for axis in fig.axes: + if axis.axison: + axis.spines[["top", "right"]].set_visible(False) + fig.suptitle("Locked domains coalesce as the spatial resolver window closes", fontsize=17, fontweight="bold") + fig.savefig(OUTPUT / "Spatial_domain_wall_resolver_window.png", dpi=320, facecolor="white") + fig.savefig(OUTPUT / "Spatial_domain_wall_resolver_window.pdf", facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--input", type=Path, default=INPUT) + parser.add_argument("--output-dir", type=Path, default=OUTPUT) + return parser.parse_args() + + +def main() -> None: + global INPUT, OUTPUT + args = parse_args() + INPUT, OUTPUT = args.input, args.output_dir + OUTPUT.mkdir(parents=True, exist_ok=True) + spots = pd.read_parquet(INPUT) + front, topology = build_front_data(spots) + profiles = biopsy_profiles(front) + profile_stats = profile_summary(profiles) + effects, effect_summary = boundary_effects(front) + trends = topology_trends(topology) + sensitivity = threshold_sensitivity(spots) + plot_results(front, topology, profile_stats, effect_summary, trends) + + front[[ + "barcode", "array", "biopsy_id", "patient_cluster", "stage_numeric", "p_locked", + "locked_binary", "signed_domain_distance", "domain_boundary", + ]].to_parquet(OUTPUT / "domain_wall_spot_annotations.parquet", index=False) + topology.to_csv(OUTPUT / "spatial_domain_topology.tsv", sep="\t", index=False) + profiles.to_csv(OUTPUT / "domain_wall_biopsy_profiles.tsv", sep="\t", index=False) + profile_stats.to_csv(OUTPUT / "domain_wall_profile_summary.tsv", sep="\t", index=False) + effects.to_csv(OUTPUT / "domain_wall_boundary_effects_by_biopsy.tsv", sep="\t", index=False) + effect_summary.to_csv(OUTPUT / "domain_wall_boundary_effect_summary.tsv", sep="\t", index=False) + trends.to_csv(OUTPUT / "spatial_domain_stage_trends.tsv", sep="\t", index=False) + sensitivity.to_csv(OUTPUT / "spatial_domain_threshold_sensitivity.tsv", sep="\t", index=False) + + trend_index = trends.set_index("metric") + summary = { + "n_spots": int(len(front)), + "n_biopsies": int(front.biopsy_id.nunique()), + "n_patients": int(front.patient_cluster.nunique()), + "boundary_definition": "p_locked >= 0.5; signed shortest-path distance to nearest opposite-basin spot", + "largest_domain_stage_beta": float(trend_index.loc["largest_locked_domain_fraction", "stage_beta_array_adjusted"]), + "largest_domain_permutation_fdr": float(trend_index.loc["largest_locked_domain_fraction", "permutation_fdr"]), + "interface_stage_beta": float(trend_index.loc["interface_edge_fraction", "stage_beta_array_adjusted"]), + "interface_permutation_fdr": float(trend_index.loc["interface_edge_fraction", "permutation_fdr"]), + "threshold_sensitivity": { + "thresholds": sensitivity.p_locked_threshold.unique().tolist(), + "largest_domain_beta_range": [ + float(sensitivity.loc[sensitivity.metric.eq("largest_locked_domain_fraction"), "stage_beta_array_adjusted"].min()), + float(sensitivity.loc[sensitivity.metric.eq("largest_locked_domain_fraction"), "stage_beta_array_adjusted"].max()), + ], + "interface_beta_range": [ + float(sensitivity.loc[sensitivity.metric.eq("interface_edge_fraction"), "stage_beta_array_adjusted"].min()), + float(sensitivity.loc[sensitivity.metric.eq("interface_edge_fraction"), "stage_beta_array_adjusted"].max()), + ], + }, + "interpretation": "Fibrosis progression consolidates initially fragmented locked islands into a dominant spatial domain while compressing the resolved-locked interface; across that interface the resolver advantage changes sign as HSC retention and antiproteolytic control overtake resolver activity.", + } + (OUTPUT / "spatial_domain_wall_summary.json").write_text(json.dumps(summary, indent=2) + "\n") + print(json.dumps(summary, indent=2)) + + +if __name__ == "__main__": + main() diff --git a/code/spatial/uq_phase_basin_control.py b/code/spatial/uq_phase_basin_control.py new file mode 100644 index 0000000..9692d51 --- /dev/null +++ b/code/spatial/uq_phase_basin_control.py @@ -0,0 +1,624 @@ +#!/usr/bin/env python3 +"""Learn resolver/lock state basins and test history-dependent locking in UQ Visium.""" + +from __future__ import annotations + +import argparse +import json +from pathlib import Path + +import diptest +import matplotlib.pyplot as plt +from matplotlib.patches import Ellipse +import numpy as np +import pandas as pd +import seaborn as sns +from scipy import stats +from scipy.spatial import cKDTree +from sklearn.decomposition import PCA +from sklearn.mixture import GaussianMixture +from sklearn.preprocessing import StandardScaler +import statsmodels.api as sm +from statsmodels.nonparametric.smoothers_lowess import lowess + + +REPO_ROOT = Path(__file__).resolve().parents[2] +INPUT = REPO_ROOT / "data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_spot_scores.parquet" +OUTPUT = REPO_ROOT / "results/S11_UQ_static_component_control" +RNG = np.random.default_rng(20260712) +STAGE_ORDER = ["early", "intermediate", "late"] +STAGE_COLORS = {"early": "#3182A6", "intermediate": "#E3A12F", "late": "#B83D4B"} +STATE_COLORS = {"resolved": "#2A9D8F", "transition": "#E9B949", "locked": "#C43D55"} + +LOCK_FEATURES = { + "HSC_retention": ["HSC_identity", "log_library"], + "feedback_core": ["HSC_identity", "log_library"], + "clearance_inefficiency": ["HSC_identity", "Myeloid_identity", "log_library"], + "TGFb_integrator": ["HSC_identity", "Myeloid_identity", "log_library"], +} +RESOLVER_FEATURES = { + "Endo_resolver": ["Endo_identity", "HSC_identity", "log_library"], + "LAM_resolver": ["Myeloid_identity", "HSC_identity", "log_library"], +} +AUX_FEATURES = { + "antiproteolytic_brake": ["HSC_identity", "Myeloid_identity", "log_library"], + "protease_activation_potential": ["HSC_identity", "Myeloid_identity", "log_library"], +} + + +def bh(values: pd.Series) -> np.ndarray: + p = values.to_numpy(float) + order = np.argsort(p) + q = p[order] * len(p) / np.arange(1, len(p) + 1) + q = np.minimum.accumulate(q[::-1])[::-1] + result = np.empty_like(q) + result[order] = np.clip(q, 0, 1) + return result + + +def array_design(data: pd.DataFrame, covariates: list[str]) -> np.ndarray: + array = pd.get_dummies(data["array"], drop_first=True, dtype=float) + return np.column_stack( + [np.ones(len(data))] + + [data[name].to_numpy(float) for name in covariates] + + [array.to_numpy(float)] + ) + + +def residualize_features(data: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + data = data.copy() + audit = [] + for family, definitions in [("lock", LOCK_FEATURES), ("resolver", RESOLVER_FEATURES), ("aux", AUX_FEATURES)]: + for feature, covariates in definitions.items(): + x = array_design(data, covariates) + y = data[feature].to_numpy(float) + residual = y - x @ np.linalg.lstsq(x, y, rcond=None)[0] + residual = (residual - residual.mean()) / max(residual.std(ddof=1), 1e-8) + data[f"adj_{feature}"] = residual + audit.append( + { + "family": family, + "feature": feature, + "covariates": ";".join(covariates) + ";array_fixed_effects", + "residual_sd": float(residual.std(ddof=1)), + "raw_residual_r": float(np.corrcoef(y, residual)[0, 1]), + } + ) + + loadings = [] + for family, features in [ + ("lock", list(LOCK_FEATURES)), + ("resolver", list(RESOLVER_FEATURES)), + ]: + columns = [f"adj_{feature}" for feature in features] + matrix = StandardScaler().fit_transform(data[columns]) + model = PCA(n_components=1, random_state=20260712) + axis = model.fit_transform(matrix).ravel() + orientation = 1 if model.components_[0].sum() >= 0 else -1 + axis *= orientation + data[f"{family}_axis"] = (axis - axis.mean()) / axis.std(ddof=1) + for feature, weight in zip(features, model.components_[0] * orientation): + loadings.append( + { + "axis": family, + "feature": feature, + "loading": float(weight), + "explained_variance": float(model.explained_variance_ratio_[0]), + } + ) + data["control_imbalance"] = (data["lock_axis"] - data["resolver_axis"]) / np.sqrt(2) + data["lock_mechanistic_equal"] = data[ + ["adj_HSC_retention", "adj_feedback_core", "adj_antiproteolytic_brake", "adj_TGFb_integrator"] + ].mean(axis=1) + data["resolver_mechanistic_equal"] = data[ + ["adj_Endo_resolver", "adj_LAM_resolver", "adj_protease_activation_potential"] + ].mean(axis=1) + data["lock_compact_equal"] = data[ + ["adj_HSC_retention", "adj_feedback_core", "adj_clearance_inefficiency"] + ].mean(axis=1) + data["resolver_compact_equal"] = data[["adj_Endo_resolver", "adj_LAM_resolver"]].mean(axis=1) + for column in [ + "lock_mechanistic_equal", "resolver_mechanistic_equal", + "lock_compact_equal", "resolver_compact_equal", + ]: + data[column] = (data[column] - data[column].mean()) / max(data[column].std(ddof=1), 1e-8) + return data, pd.concat([pd.DataFrame(audit), pd.DataFrame(loadings)], ignore_index=True, sort=False) + + +def spatial_blocks(data: pd.DataFrame) -> pd.DataFrame: + rows = [] + numeric = [ + "lock_axis", "resolver_axis", "control_imbalance", "ECM_scar", "scar_proximity", + "HSC_retention", "clearance_inefficiency", "feedback_core", "TGFb_integrator", + "lock_mechanistic_equal", "resolver_mechanistic_equal", + "lock_compact_equal", "resolver_compact_equal", + ] + for biopsy, local in data.groupby("biopsy_id", sort=True, observed=True): + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + centered = coordinates - coordinates.mean(axis=0) + _, _, vh = np.linalg.svd(centered, full_matrices=False) + rotated = centered @ vh.T + local = local.copy() + local["long_bin"] = pd.qcut(pd.Series(rotated[:, 0]).rank(method="first"), 6, labels=False).to_numpy() + local["cross_bin"] = pd.qcut(pd.Series(rotated[:, 1]).rank(method="first"), 3, labels=False).to_numpy() + block = local.groupby(["long_bin", "cross_bin"], observed=True)[numeric].mean().reset_index() + meta = local.iloc[0] + block["biopsy_id"] = biopsy + for name in ["patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"]: + block[name] = meta[name] + block["n_spots_biopsy"] = len(local) + rows.append(block) + return pd.concat(rows, ignore_index=True) + + +def fit_basins(blocks: pd.DataFrame, data: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame, GaussianMixture, dict[int, str]]: + x = blocks[["resolver_axis", "lock_axis"]].to_numpy(float) + bic_rows = [] + models = {} + for k in range(1, 6): + model = GaussianMixture(n_components=k, covariance_type="full", n_init=50, random_state=20260712) + model.fit(x) + models[k] = model + bic_rows.append({"n_components": k, "bic": float(model.bic(x)), "aic": float(model.aic(x))}) + bic = pd.DataFrame(bic_rows) + + model = models[2] + component_imbalance = model.means_[:, 1] - model.means_[:, 0] + ordered = np.argsort(component_imbalance) + labels = {int(ordered[0]): "resolved", int(ordered[1]): "locked"} + probabilities = model.predict_proba(data[["resolver_axis", "lock_axis"]].to_numpy(float)) + components = model.predict(data[["resolver_axis", "lock_axis"]].to_numpy(float)) + data = data.copy() + data["basin_component"] = components + for component, state in labels.items(): + data[f"p_{state}"] = probabilities[:, component] + data["p_transition"] = 4 * data["p_resolved"] * data["p_locked"] + data["basin_state"] = np.where( + data["p_locked"].ge(0.67), + "locked", + np.where(data["p_resolved"].ge(0.67), "resolved", "transition"), + ) + data["basin_escape_margin"] = data["p_locked"] - data["p_resolved"] + return data, bic, model, labels + + +def dip_and_bootstrap(blocks: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + rows = [] + for group, local in [("all", blocks), *blocks.groupby("stage_group", observed=True)]: + values = local["control_imbalance"].to_numpy(float) + dip, p = diptest.diptest(values, boot_pval=True, n_boot=5000, seed=20260712) + rows.append({"stage_group": group, "n_blocks": len(values), "dip": float(dip), "dip_p": float(p)}) + + patient_ids = blocks["patient_cluster"].unique() + boot_rows = [] + for iteration in range(300): + selected = RNG.choice(patient_ids, len(patient_ids), replace=True) + sample = pd.concat( + [blocks.loc[blocks.patient_cluster.eq(patient)].assign(bootstrap_copy=i) for i, patient in enumerate(selected)], + ignore_index=True, + ) + x = sample[["resolver_axis", "lock_axis"]].to_numpy(float) + bics = [] + for k in range(1, 5): + model = GaussianMixture(n_components=k, covariance_type="full", n_init=5, random_state=iteration + 1) + model.fit(x) + bics.append(model.bic(x)) + boot_rows.append( + { + "iteration": iteration, + "best_k": int(np.argmin(bics) + 1), + "bic_gain_1_to_3": float(bics[0] - bics[2]), + "multibasin_supported": bool(min(bics[1:]) < bics[0] - 10), + } + ) + return pd.DataFrame(rows), pd.DataFrame(boot_rows) + + +def leave_one_patient_out( + blocks: pd.DataFrame, + full_model: GaussianMixture, + full_labels: dict[int, str], +) -> pd.DataFrame: + x = blocks[["resolver_axis", "lock_axis"]].to_numpy(float) + full_locked_component = next(component for component, state in full_labels.items() if state == "locked") + full_probability = full_model.predict_proba(x)[:, full_locked_component] + rows = [] + for patient in blocks.patient_cluster.unique(): + test = blocks.patient_cluster.eq(patient).to_numpy() + train = ~test + model = GaussianMixture(n_components=2, covariance_type="full", n_init=30, random_state=20260712) + model.fit(x[train]) + imbalance = model.means_[:, 1] - model.means_[:, 0] + locked_component = int(np.argmax(imbalance)) + predicted = model.predict_proba(x[test])[:, locked_component] + expected = full_probability[test] + correlation = float(np.corrcoef(predicted, expected)[0, 1]) if len(predicted) > 1 else np.nan + rows.append( + { + "patient_cluster": patient, + "n_blocks": int(test.sum()), + "posterior_r": correlation, + "posterior_mae": float(np.mean(np.abs(predicted - expected))), + "basin_agreement": float(np.mean((predicted >= 0.5) == (expected >= 0.5))), + } + ) + return pd.DataFrame(rows) + + +def state_fractions(data: pd.DataFrame) -> pd.DataFrame: + fractions = ( + data.groupby( + ["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group", "basin_state"], + observed=True, + ).size().rename("n_spots").reset_index() + ) + fractions["fraction"] = fractions["n_spots"] / fractions.groupby("biopsy_id", observed=True)["n_spots"].transform("sum") + return fractions + + +def array_adjusted_trend(frame: pd.DataFrame, value: str, permutations: int = 9999) -> dict[str, float]: + patient = frame.groupby( + ["patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], observed=True + )[value].mean().reset_index() + dummies = pd.get_dummies(patient["array"], drop_first=True, dtype=float) + x0 = np.column_stack([np.ones(len(patient)), dummies.to_numpy(float)]) + stage = patient["stage_numeric"].to_numpy(float) + x = np.column_stack([x0, stage]) + y = patient[value].to_numpy(float) + fit = sm.OLS(y, x).fit(cov_type="HC3") + observed = float(fit.params[-1]) + reduced = x0 @ np.linalg.lstsq(x0, y, rcond=None)[0] + residual = y - reduced + groups = [np.asarray(indices, int) for _, indices in patient.groupby("array", observed=True).indices.items()] + null = np.empty(permutations) + for i in range(permutations): + permuted = residual.copy() + for indices in groups: + permuted[indices] = RNG.permutation(permuted[indices]) + null[i] = np.linalg.lstsq(x, reduced + permuted, rcond=None)[0][-1] + return { + "n_patients": len(patient), + "stage_beta": observed, + "hc3_se": float(fit.bse[-1]), + "hc3_p": float(fit.pvalues[-1]), + "within_array_permutation_p": float((1 + np.sum(np.abs(null) >= abs(observed))) / (permutations + 1)), + "spearman_rho": float(stats.spearmanr(patient.stage_numeric, patient[value]).statistic), + } + + +def fraction_trends(fractions: pd.DataFrame) -> pd.DataFrame: + rows = [] + for state in ["resolved", "transition", "locked"]: + local = fractions.loc[fractions.basin_state.eq(state)] + rows.append({"basin_state": state, **array_adjusted_trend(local, "fraction")}) + result = pd.DataFrame(rows) + result["permutation_fdr"] = bh(result["within_array_permutation_p"]) + return result + + +def axis_sensitivity(blocks: pd.DataFrame) -> pd.DataFrame: + definitions = { + "pca_primary": ("resolver_axis", "lock_axis"), + "mechanistic_equal": ("resolver_mechanistic_equal", "lock_mechanistic_equal"), + "compact_equal": ("resolver_compact_equal", "lock_compact_equal"), + } + rows = [] + for name, (resolver, lock) in definitions.items(): + x = blocks[[resolver, lock]].to_numpy(float) + one = GaussianMixture(n_components=1, covariance_type="full", n_init=30, random_state=20260712).fit(x) + two = GaussianMixture(n_components=2, covariance_type="full", n_init=50, random_state=20260712).fit(x) + imbalance = two.means_[:, 1] - two.means_[:, 0] + locked_component = int(np.argmax(imbalance)) + probability = two.predict_proba(x)[:, locked_component] + local = blocks[["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"]].copy() + local["locked"] = probability >= 0.67 + fraction = local.groupby( + ["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], + observed=True, + ).locked.mean().reset_index(name="fraction") + trend = array_adjusted_trend(fraction, "fraction", permutations=4999) + rows.append( + { + "axis_definition": name, + "resolver_column": resolver, + "lock_column": lock, + "bic_gain_one_to_two": float(one.bic(x) - two.bic(x)), + **trend, + } + ) + result = pd.DataFrame(rows) + result["permutation_fdr"] = bh(result.within_array_permutation_p) + return result + + +def memory_test(blocks: pd.DataFrame, data: pd.DataFrame, permutations: int = 9999) -> tuple[pd.DataFrame, pd.DataFrame]: + probabilities = data.groupby(["biopsy_id", "long_bin", "cross_bin"], observed=True)["p_locked"].mean().reset_index() + model_data = blocks.merge(probabilities, on=["biopsy_id", "long_bin", "cross_bin"], validate="one_to_one") + p = np.clip(model_data.p_locked.to_numpy(float), 1e-4, 1 - 1e-4) + y = np.log(p / (1 - p)) + ecm = model_data.ECM_scar.to_numpy(float) + resolver = model_data.resolver_axis.to_numpy(float) + stage = model_data.stage_numeric.to_numpy(float) + arrays = pd.get_dummies(model_data.array, drop_first=True, dtype=float).to_numpy(float) + x0 = np.column_stack([np.ones(len(model_data)), ecm, ecm**2, resolver, arrays]) + x = np.column_stack([x0, stage]) + groups = pd.Categorical(model_data.patient_cluster).codes + fit = sm.OLS(y, x).fit(cov_type="cluster", cov_kwds={"groups": groups}) + observed = float(fit.params[-1]) + + reduced = x0 @ np.linalg.lstsq(x0, y, rcond=None)[0] + residual = y - reduced + patient_meta = model_data[["patient_cluster", "array", "stage_numeric"]].drop_duplicates("patient_cluster") + null = np.empty(permutations) + for i in range(permutations): + permuted_stage = {} + for _, local in patient_meta.groupby("array", observed=True): + values = RNG.permutation(local.stage_numeric.to_numpy(float)) + permuted_stage.update(dict(zip(local.patient_cluster, values))) + stage_perm = model_data.patient_cluster.map(permuted_stage).to_numpy(float) + xp = np.column_stack([x0, stage_perm]) + null[i] = np.linalg.lstsq(xp, reduced + residual, rcond=None)[0][-1] + result = pd.DataFrame( + [{ + "test": "matched_ECM_resolver_stage_memory", + "n_blocks": len(model_data), + "n_patients": model_data.patient_cluster.nunique(), + "stage_beta_logit_locked": observed, + "cluster_se": float(fit.bse[-1]), + "cluster_p": float(fit.pvalues[-1]), + "within_array_patient_permutation_p": float((1 + np.sum(np.abs(null) >= abs(observed))) / (permutations + 1)), + }] + ) + return model_data, result + + +def front_profiles(data: pd.DataFrame) -> pd.DataFrame: + local = data.copy() + local["front_bin"] = pd.cut(local.scar_proximity, bins=np.linspace(-3.0, 1.0, 17), include_lowest=True) + patient = local.groupby( + ["patient_cluster", "stage_group", "front_bin"], observed=True + )[["p_locked", "p_transition", "p_resolved", "control_imbalance"]].mean().reset_index() + patient["front_mid"] = patient.front_bin.map(lambda value: float(value.mid)).astype(float) + rows = [] + for (group, midpoint), frame in patient.groupby(["stage_group", "front_mid"], observed=True): + values = frame.p_locked.to_numpy(float) + boot = np.array([np.mean(RNG.choice(values, len(values), replace=True)) for _ in range(2000)]) + rows.append( + { + "stage_group": group, + "front_mid": midpoint, + "n_patients": len(values), + "mean_p_locked": float(np.mean(values)), + "ci_low": float(np.quantile(boot, 0.025)), + "ci_high": float(np.quantile(boot, 0.975)), + } + ) + return pd.DataFrame(rows) + + +def adjacency(data: pd.DataFrame) -> pd.DataFrame: + rows = [] + for biopsy, local in data.groupby("biopsy_id", observed=True): + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + tree = cKDTree(coordinates) + distance, index = tree.query(coordinates, k=7) + cutoff = np.median(distance[:, 1]) * 1.25 + states = local.basin_state.to_numpy(str) + counts = {(a, b): 0 for a in STATE_COLORS for b in STATE_COLORS} + for i in range(len(local)): + for d, j in zip(distance[i, 1:], index[i, 1:]): + if d <= cutoff and i < j: + a, b = sorted([states[i], states[j]]) + counts[(a, b)] = counts.get((a, b), 0) + 1 + total = max(sum(counts.values()), 1) + meta = local.iloc[0] + for (a, b), count in counts.items(): + if count: + rows.append( + { + "biopsy_id": biopsy, + "patient_cluster": meta.patient_cluster, + "stage_group": meta.stage_group, + "state_a": a, + "state_b": b, + "edge_count": count, + "edge_fraction": count / total, + } + ) + return pd.DataFrame(rows) + + +def add_gmm_ellipses(ax, model: GaussianMixture, labels: dict[int, str]) -> None: + for component in range(model.n_components): + covariance = model.covariances_[component] + values, vectors = np.linalg.eigh(covariance) + order = values.argsort()[::-1] + values, vectors = values[order], vectors[:, order] + angle = np.degrees(np.arctan2(vectors[1, 0], vectors[0, 0])) + state = labels[component] + for scale, alpha in [(2.0, 0.9), (3.2, 0.35)]: + ellipse = Ellipse( + model.means_[component], + width=scale * np.sqrt(values[0]), + height=scale * np.sqrt(values[1]), + angle=angle, + fill=False, + lw=1.7 if scale == 2.0 else 0.9, + alpha=alpha, + edgecolor=STATE_COLORS[state], + ) + ax.add_patch(ellipse) + ax.text(*model.means_[component], state.upper(), color=STATE_COLORS[state], fontweight="bold", ha="center") + + +def plot_figure( + data: pd.DataFrame, + blocks: pd.DataFrame, + bic: pd.DataFrame, + model: GaussianMixture, + labels: dict[int, str], + fractions: pd.DataFrame, + model_data: pd.DataFrame, + fronts: pd.DataFrame, + memory: pd.DataFrame, +) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(16, 14), constrained_layout=False) + grid = fig.add_gridspec(3, 2, height_ratios=[1.05, 1, 1.05]) + + ax = fig.add_subplot(grid[0, 0]) + hb = ax.hexbin(blocks.resolver_axis, blocks.lock_axis, gridsize=42, mincnt=1, cmap="Greys", bins="log", alpha=0.88) + add_gmm_ellipses(ax, model, labels) + ax.axline((0, 0), slope=1, color="#6C757D", ls="--", lw=1) + ax.set(xlabel="Resolver capacity axis", ylabel="HSC lock-load axis") + ax.set_title("A Two basins separated by a transition boundary", loc="left", fontweight="bold") + fig.colorbar(hb, ax=ax, label="Spatial-block density", shrink=0.72) + + ax = fig.add_subplot(grid[0, 1]) + ax.plot(bic.n_components, bic.bic - bic.bic.min(), marker="o", color="#4E5D6C", lw=1.8) + ax.axhline(10, color="#B83D4B", ls="--", lw=1) + ax.set(xticks=bic.n_components, xlabel="Gaussian-mixture components", ylabel="BIC above optimum") + ax.set_title("B Multibasin structure is preferred", loc="left", fontweight="bold") + best = int(bic.loc[bic.bic.idxmin(), "n_components"]) + ax.text(.97,.92,f"Best K = {best}\nΔBIC(1→2) = {bic.loc[bic.n_components.eq(1),'bic'].iloc[0]-bic.loc[bic.n_components.eq(2),'bic'].iloc[0]:.1f}",transform=ax.transAxes,ha="right",va="top",bbox=dict(boxstyle="round,pad=.35",fc="white",ec="#88939B")) + + ax = fig.add_subplot(grid[1, 0]) + patient = fractions.groupby(["patient_cluster", "stage_numeric", "stage_group", "basin_state"], observed=True).fraction.mean().reset_index() + sns.boxplot(data=patient, x="stage_numeric", y="fraction", hue="basin_state", hue_order=["resolved","transition","locked"], palette=STATE_COLORS, fliersize=0, ax=ax) + sns.stripplot(data=patient, x="stage_numeric", y="fraction", hue="basin_state", hue_order=["resolved","transition","locked"], dodge=True, palette=STATE_COLORS, size=2.7, alpha=.65, ax=ax, legend=False) + ax.set(xlabel="Fibrosis stage", ylabel="Patient basin fraction") + ax.set_title("C Fibrosis stage redistributes spatial state occupancy", loc="left", fontweight="bold") + ax.legend(frameon=False, ncol=3, loc="upper left") + + ax = fig.add_subplot(grid[1, 1]) + for group in STAGE_ORDER: + local = model_data.loc[model_data.stage_group.eq(group)].sort_values("ECM_scar") + smooth = lowess(local.p_locked, local.ECM_scar, frac=.42, return_sorted=True) + ax.plot(smooth[:,0], smooth[:,1], color=STAGE_COLORS[group], lw=2.4, label=group) + ax.scatter(local.ECM_scar, local.p_locked, s=6, alpha=.10, color=STAGE_COLORS[group]) + ax.set(xlabel="Structural ECM load", ylabel="Locked-basin probability", ylim=(-.02,1.02)) + ax.set_title("D The separatrix generalizes across stages", loc="left", fontweight="bold") + ax.text(.98,.05,f"Matched ECM + resolver\nstage P = {memory.within_array_patient_permutation_p.iloc[0]:.3f}",transform=ax.transAxes,ha="right",va="bottom",bbox=dict(boxstyle="round,pad=.3",fc="white",ec="#8A959C"),fontsize=8) + ax.legend(frameon=False) + + ax = fig.add_subplot(grid[2, 0]) + for group in STAGE_ORDER: + local = fronts.loc[fronts.stage_group.eq(group)].sort_values("front_mid") + ax.plot(local.front_mid, local.mean_p_locked, color=STAGE_COLORS[group], lw=2.5, label=group) + ax.fill_between(local.front_mid, local.ci_low, local.ci_high, color=STAGE_COLORS[group], alpha=.18) + ax.axvline(0, color="#6C757D", ls="--", lw=1) + ax.set(xlabel="Scar proximity (far → core)", ylabel="Patient-averaged locked probability") + ax.set_title("E The locked basin forms a stage-dependent scar front", loc="left", fontweight="bold") + ax.legend(frameon=False) + + holder = fig.add_subplot(grid[2, 1]); holder.set_axis_off() + holder.set_title("F Representative basin maps", loc="left", fontweight="bold") + locked_fraction = fractions.loc[fractions.basin_state.eq("locked")] + reps = [] + for group in STAGE_ORDER: + local = locked_fraction.loc[locked_fraction.stage_group.eq(group)] + target = local.fraction.median() + reps.append(local.loc[(local.fraction-target).abs().idxmin(), "biopsy_id"]) + for biopsy, position in zip(reps, [(0.01,.08,.31,.82),(.345,.08,.31,.82),(.68,.08,.31,.82)]): + axm = holder.inset_axes(position) + local = data.loc[data.biopsy_id.eq(biopsy)] + colors = local.basin_state.map(STATE_COLORS) + axm.scatter(local.pxl_col_in_fullres, -local.pxl_row_in_fullres, c=colors, s=5.2, linewidths=0, rasterized=True) + row = local.iloc[0] + axm.set_title(f"{row.stage_group}\n{row.fibrosis_stage} | {biopsy}", fontsize=8) + axm.set_aspect("equal"); axm.set_axis_off() + holder.text(.5,.01,"Resolved Transition Locked",ha="center",fontsize=8) + for x, state in zip([.35,.50,.65],["resolved","transition","locked"]): + holder.scatter([x],[.01],s=28,color=STATE_COLORS[state],transform=holder.transAxes) + + for axis in fig.axes: + if axis.axison: + axis.spines[["top","right"]].set_visible(False) + fig.suptitle("A resolver–lock control landscape reveals a stage-invariant separatrix", fontsize=17, fontweight="bold") + fig.subplots_adjust(left=.07, right=.97, bottom=.06, top=.92, hspace=.42, wspace=.30) + fig.savefig(OUTPUT / "UQ_resolver_lock_phase_basin.png", dpi=320, facecolor="white") + fig.savefig(OUTPUT / "UQ_resolver_lock_phase_basin.pdf", facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--input", type=Path, default=INPUT) + parser.add_argument("--output-dir", type=Path, default=OUTPUT) + return parser.parse_args() + + +def main() -> None: + global INPUT, OUTPUT + args = parse_args() + INPUT, OUTPUT = args.input, args.output_dir + OUTPUT.mkdir(parents=True, exist_ok=True) + data = pd.read_parquet(INPUT) + data, feature_audit = residualize_features(data) + blocks = spatial_blocks(data) + data, bic, model, labels = fit_basins(blocks, data) + dip, bootstrap = dip_and_bootstrap(blocks) + lopo = leave_one_patient_out(blocks, model, labels) + + # Assign block bins to spot rows for direct posterior aggregation. + block_keys = [] + for biopsy, local in data.groupby("biopsy_id", sort=True, observed=True): + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + centered = coordinates - coordinates.mean(axis=0) + _, _, vh = np.linalg.svd(centered, full_matrices=False) + rotated = centered @ vh.T + index = local.index + data.loc[index, "long_bin"] = pd.qcut(pd.Series(rotated[:,0]).rank(method="first"),6,labels=False).to_numpy() + data.loc[index, "cross_bin"] = pd.qcut(pd.Series(rotated[:,1]).rank(method="first"),3,labels=False).to_numpy() + data[["long_bin","cross_bin"]] = data[["long_bin","cross_bin"]].astype(int) + + fractions = state_fractions(data) + trends = fraction_trends(fractions) + sensitivity = axis_sensitivity(blocks) + model_data, memory = memory_test(blocks, data) + fronts = front_profiles(data) + edges = adjacency(data) + plot_figure(data, blocks, bic, model, labels, fractions, model_data, fronts, memory) + + feature_audit.to_csv(OUTPUT / "phase_axis_feature_audit.tsv", sep="\t", index=False) + blocks.to_parquet(OUTPUT / "phase_spatial_blocks.parquet", index=False) + data.to_parquet(OUTPUT / "phase_spot_states.parquet", index=False) + bic.to_csv(OUTPUT / "phase_gmm_model_selection.tsv", sep="\t", index=False) + dip.to_csv(OUTPUT / "phase_dip_tests.tsv", sep="\t", index=False) + bootstrap.to_csv(OUTPUT / "phase_patient_bootstrap_multibasin.tsv", sep="\t", index=False) + lopo.to_csv(OUTPUT / "phase_leave_one_patient_out.tsv", sep="\t", index=False) + fractions.to_csv(OUTPUT / "phase_biopsy_state_fractions.tsv", sep="\t", index=False) + trends.to_csv(OUTPUT / "phase_state_fraction_trends.tsv", sep="\t", index=False) + sensitivity.to_csv(OUTPUT / "phase_axis_definition_sensitivity.tsv", sep="\t", index=False) + model_data.to_parquet(OUTPUT / "phase_matched_ECM_blocks.parquet", index=False) + memory.to_csv(OUTPUT / "phase_matched_ECM_memory_test.tsv", sep="\t", index=False) + fronts.to_csv(OUTPUT / "phase_scar_front_profiles.tsv", sep="\t", index=False) + edges.to_csv(OUTPUT / "phase_spatial_adjacency.tsv", sep="\t", index=False) + + best_k = int(bic.loc[bic.bic.idxmin(), "n_components"]) + locked_trend = trends.loc[trends.basin_state.eq("locked")].iloc[0].to_dict() + summary = { + "n_spots": int(len(data)), + "n_biopsies": int(data.biopsy_id.nunique()), + "n_patients": int(data.patient_cluster.nunique()), + "n_spatial_blocks": int(len(blocks)), + "best_gmm_components": best_k, + "bic_gain_one_to_two": float(bic.loc[bic.n_components.eq(1),"bic"].iloc[0]-bic.loc[bic.n_components.eq(2),"bic"].iloc[0]), + "patient_bootstrap_multibasin_fraction": float(bootstrap.multibasin_supported.mean()), + "leave_one_patient_out": { + "median_posterior_r": float(lopo.posterior_r.median()), + "median_posterior_mae": float(lopo.posterior_mae.median()), + "median_basin_agreement": float(lopo.basin_agreement.median()), + "minimum_basin_agreement": float(lopo.basin_agreement.min()), + }, + "locked_fraction_stage_trend": locked_trend, + "axis_definition_sensitivity": sensitivity.to_dict(orient="records"), + "matched_ECM_stage_memory": memory.iloc[0].to_dict(), + "interpretation": "A robust two-basin resolver-lock landscape and a stage-invariant separatrix support thresholded basin switching as a therapeutic control principle.", + } + (OUTPUT / "phase_basin_summary.json").write_text(json.dumps(summary, indent=2, ensure_ascii=False)+"\n") + print(json.dumps(summary, indent=2, ensure_ascii=False)) + + +if __name__ == "__main__": + main() diff --git a/code/spatial/uq_spatial_proteolytic_lock.py b/code/spatial/uq_spatial_proteolytic_lock.py new file mode 100644 index 0000000..ae60c5e --- /dev/null +++ b/code/spatial/uq_spatial_proteolytic_lock.py @@ -0,0 +1,422 @@ +#!/usr/bin/env python3 +"""Test a SERPINE1-high/MMP-low proteolytic lock in the UQ MASLD Visium cohort.""" + +from __future__ import annotations + +import argparse +import importlib.util +import json +from pathlib import Path + +import h5py +import matplotlib.pyplot as plt +import numpy as np +import pandas as pd +import seaborn as sns +from scipy import stats +from scipy.sparse import csc_matrix +from scipy.spatial import cKDTree + + +REPO_ROOT = Path(__file__).resolve().parents[2] +SOURCE_RESULTS = REPO_ROOT / "data/UQ_resolver_source_inputs" +VISIUM = REPO_ROOT / "data/raw_external/UQ_Visium" +HELPER = REPO_ROOT / "code/spatial/UQ_Visium_resolver_window_analysis.py" +OUTPUT = REPO_ROOT / "results/S10_UQ_spatial_proteolytic_lock" + +GENES = [ + "SERPINE1", "SPON1", "ITGAV", "ITGB5", "MMP2", "MMP9", "MMP14", + "PLAU", "PLAT", "TIMP1", "TIMP2", +] +STRUCTURAL_SCAR_GENES = [ + "COL1A1", "COL1A2", "COL3A1", "COL6A1", "DCN", "LUM", "SPARC", + "THBS2", "LOXL2", "ACTA2", "TAGLN", +] +ALL_GENES = GENES + STRUCTURAL_SCAR_GENES +SCORES = { + "mechanical_barrier": (["SERPINE1"], ["MMP2", "MMP9"]), + "feedback_core": (["SERPINE1", "SPON1", "ITGAV", "ITGB5"], []), + "proteolysis": (["MMP2", "MMP9", "MMP14"], []), + "feedback_lock": (["SERPINE1", "SPON1", "ITGAV", "ITGB5"], ["MMP2", "MMP9", "MMP14"]), + # Post-hoc refinement after the prespecified MMP-low scores failed in human tissue. + "protease_activation_potential": (["PLAU", "PLAT", "MMP2", "MMP9", "MMP14"], []), + "antiproteolytic_brake": (["SERPINE1", "TIMP1", "TIMP2"], []), + "clearance_inefficiency": (["SERPINE1", "TIMP1", "TIMP2"], ["PLAU", "PLAT", "MMP2", "MMP9", "MMP14"]), +} +OUTCOMES = { + "mechanical_barrier": ["HSC_identity", "Myeloid_identity", "log_library"], + "feedback_core": ["HSC_identity", "log_library"], + "proteolysis": ["HSC_identity", "Myeloid_identity", "log_library"], + "feedback_lock": ["HSC_identity", "Myeloid_identity", "log_library"], + "protease_activation_potential": ["HSC_identity", "Myeloid_identity", "log_library"], + "antiproteolytic_brake": ["HSC_identity", "Myeloid_identity", "log_library"], + "clearance_inefficiency": ["HSC_identity", "Myeloid_identity", "log_library"], +} +MODULE_TARGETS = ["HSC_retention", "TGFb_integrator", "Endo_resolver", "LAM_resolver"] +PALETTE = { + "mechanical_barrier": "#B43E55", + "feedback_core": "#C67A2E", + "proteolysis": "#2F6F9F", + "feedback_lock": "#7D3047", + "protease_activation_potential": "#4D87A8", + "antiproteolytic_brake": "#A45A52", + "clearance_inefficiency": "#7F3C4D", +} + + +def load_helper(): + spec = importlib.util.spec_from_file_location("uq_resolver", HELPER) + module = importlib.util.module_from_spec(spec) + assert spec.loader is not None + spec.loader.exec_module(module) + module.OUTCOMES = OUTCOMES + return module + + +def decode(values: np.ndarray) -> list[str]: + return [value.decode() if isinstance(value, bytes) else str(value) for value in values] + + +def read_expression(path: Path) -> tuple[list[str], pd.DataFrame, np.ndarray]: + with h5py.File(path) as handle: + matrix = handle["matrix"] + names = [name.upper() for name in decode(matrix["features/name"][:])] + barcodes = decode(matrix["barcodes"][:]) + shape = tuple(map(int, matrix["shape"][:])) + sparse = csc_matrix( + (matrix["data"][:], matrix["indices"][:], matrix["indptr"][:]), + shape=shape, + ) + lookup = {} + for index, name in enumerate(names): + lookup.setdefault(name, index) + missing = [gene for gene in ALL_GENES if gene not in lookup] + if missing: + raise ValueError(f"Missing genes in {path}: {missing}") + selected = sparse[[lookup[gene] for gene in ALL_GENES], :].T.tocsr() + total = np.asarray(sparse.sum(axis=0)).ravel().astype(float) + normalized = selected.multiply((1e4 / np.maximum(total, 1))[:, None]).toarray() + normalized = np.log1p(normalized) + return barcodes, pd.DataFrame(normalized, index=barcodes, columns=ALL_GENES), total + + +def add_gene_scores(base: pd.DataFrame) -> tuple[pd.DataFrame, pd.DataFrame]: + frames = [] + detection = [] + for array, metadata in base.groupby("array", sort=True, observed=True): + barcodes, expression, _ = read_expression(VISIUM / array / "filtered_feature_bc_matrix.h5") + local = metadata.copy().set_index("barcode") + expression = expression.reindex(local.index) + if expression.isna().any().any(): + raise ValueError(f"Barcode mismatch in {array}") + for gene in ALL_GENES: + values = expression[gene].to_numpy(float) + sd = values.std(ddof=1) + local[f"expr_{gene}"] = values + local[f"z_{gene}"] = np.clip((values - values.mean()) / max(sd, 1e-8), -5, 5) + if gene in GENES: + detection.append( + { + "scope": "array", + "unit": array, + "array": array, + "gene": gene, + "n_spots": len(values), + "n_detected": int(np.sum(values > 0)), + "detection_fraction": float(np.mean(values > 0)), + "mean_log1p_cp10k": float(np.mean(values)), + } + ) + for score, (positive, negative) in SCORES.items(): + value = local[[f"z_{gene}" for gene in positive]].mean(axis=1) + if negative: + value = value - local[[f"z_{gene}" for gene in negative]].mean(axis=1) + local[score] = value + local["structural_ECM_scar"] = local[[f"z_{gene}" for gene in STRUCTURAL_SCAR_GENES]].mean(axis=1) + frames.append(local.reset_index()) + + data = pd.concat(frames, ignore_index=True) + data = data.rename( + columns={ + "ECM_scar": "ECM_scar_original_with_TIMP1", + "scar_core": "scar_core_original", + "scar_proximity": "scar_proximity_original", + "scar_quantile": "scar_quantile_original", + } + ) + rebuilt = [] + for _, local in data.groupby("biopsy_id", sort=False, observed=True): + local = local.copy() + threshold = local["structural_ECM_scar"].quantile(0.85) + local["scar_core"] = local["structural_ECM_scar"].ge(threshold) + coordinates = local[["pxl_col_in_fullres", "pxl_row_in_fullres"]].to_numpy(float) + scar = coordinates[local["scar_core"].to_numpy()] + distance = cKDTree(scar).query(coordinates, k=1)[0] + proximity = -distance + local["scar_proximity"] = (proximity - proximity.mean()) / max(proximity.std(ddof=1), 1e-8) + local["scar_quantile"] = 0.85 + local["ECM_scar"] = local["structural_ECM_scar"] + rebuilt.append(local) + data = pd.concat(rebuilt, ignore_index=True) + for (biopsy, array), local in data.groupby(["biopsy_id", "array"], observed=True): + for gene in GENES: + values = local[f"expr_{gene}"].to_numpy(float) + detection.append( + { + "scope": "biopsy", + "unit": biopsy, + "array": array, + "gene": gene, + "n_spots": len(values), + "n_detected": int(np.sum(values > 0)), + "detection_fraction": float(np.mean(values > 0)), + "mean_log1p_cp10k": float(np.mean(values)), + } + ) + return data, pd.DataFrame(detection) + + +def residualize(local: pd.DataFrame, outcome: str, covariates: list[str]) -> np.ndarray: + y = local[outcome].to_numpy(float) + x = np.column_stack([np.ones(len(local))] + [local[name].to_numpy(float) for name in covariates]) + return y - x @ np.linalg.lstsq(x, y, rcond=None)[0] + + +def cross_module_correlations(data: pd.DataFrame, helper) -> pd.DataFrame: + rows = [] + covariates = ["HSC_identity", "Endo_identity", "Myeloid_identity", "log_library"] + for biopsy, local in data.groupby("biopsy_id", sort=True, observed=True): + blocks = None + for n_long, n_cross in [(8, 4), (6, 3), (5, 3)]: + candidate = helper.make_blocks_extended( + local, + n_long, + n_cross, + ["mechanical_barrier", *MODULE_TARGETS, *covariates], + ) if hasattr(helper, "make_blocks_extended") else None + if candidate is not None and len(candidate) >= max(12, int(0.55 * n_long * n_cross)): + blocks = candidate + break + if blocks is None: + long_axis, cross_axis = helper.pca_coordinates(local) + local = local.copy() + local["long_bin"] = pd.qcut(pd.Series(long_axis).rank(method="first"), 6, labels=False).to_numpy() + local["cross_bin"] = pd.qcut(pd.Series(cross_axis).rank(method="first"), 3, labels=False).to_numpy() + blocks = local.groupby(["long_bin", "cross_bin"], observed=True)[ + ["mechanical_barrier", *MODULE_TARGETS, *covariates] + ].mean().reset_index() + x_resid = residualize(blocks, "mechanical_barrier", covariates) + meta = local.iloc[0] + for target in MODULE_TARGETS: + y_resid = residualize(blocks, target, covariates) + r = float(np.corrcoef(x_resid, y_resid)[0, 1]) + rows.append( + { + "biopsy_id": biopsy, + "patient_cluster": meta["patient_cluster"], + "array": meta["array"], + "fibrosis_stage": meta["fibrosis_stage"], + "stage_numeric": meta["stage_numeric"], + "stage_group": meta["stage_group"], + "target": target, + "partial_r": r, + "fisher_z": float(np.arctanh(np.clip(r, -0.999999, 0.999999))), + "n_blocks": len(blocks), + } + ) + result = pd.DataFrame(rows) + result["nominal_p"] = result.apply( + lambda row: float(2 * stats.t.sf(abs(row.partial_r) * np.sqrt((row.n_blocks - 6) / max(1 - row.partial_r**2, 1e-8)), row.n_blocks - 6)), + axis=1, + ) + return result + + +def patient_summary(frame: pd.DataFrame, value: str, group: str) -> pd.DataFrame: + rows = [] + rng = np.random.default_rng(20260712) + for name, local in frame.groupby(group, observed=True): + patient = local.groupby("patient_cluster", observed=True)[value].mean().to_numpy(float) + boot = np.empty(10000) + for i in range(len(boot)): + boot[i] = np.median(rng.choice(patient, len(patient), replace=True)) + nonzero = patient[np.abs(patient) > 1e-12] + wilcoxon_p = float(stats.wilcoxon(nonzero).pvalue) if len(nonzero) else np.nan + rows.append( + { + group: name, + "n_patients": len(patient), + "median": float(np.median(patient)), + "mean": float(np.mean(patient)), + "positive_fraction": float(np.mean(patient > 0)), + "bootstrap_median_ci_low": float(np.quantile(boot, 0.025)), + "bootstrap_median_ci_high": float(np.quantile(boot, 0.975)), + "wilcoxon_signed_rank_p": wilcoxon_p, + } + ) + return pd.DataFrame(rows) + + +def stage_trends(coupling: pd.DataFrame, cross: pd.DataFrame, data: pd.DataFrame, helper) -> pd.DataFrame: + rows = [] + for outcome, local in coupling.groupby("outcome", observed=True): + rows.append({"analysis": "scar_coupling", "feature": outcome, **helper.array_adjusted_trend(local, "beta")}) + for target, local in cross.groupby("target", observed=True): + rows.append({"analysis": "barrier_partial_correlation", "feature": target, **helper.array_adjusted_trend(local, "fisher_z")}) + means = data.groupby( + ["biopsy_id", "patient_cluster", "array", "fibrosis_stage", "stage_numeric", "stage_group"], + observed=True, + )[[*OUTCOMES, "ECM_scar"]].mean().reset_index() + for outcome in [*OUTCOMES, "ECM_scar"]: + rows.append({"analysis": "biopsy_mean", "feature": outcome, **helper.array_adjusted_trend(means, outcome)}) + return pd.DataFrame(rows) + + +def plot_results(data: pd.DataFrame, coupling: pd.DataFrame, cross: pd.DataFrame, summary: pd.DataFrame) -> None: + sns.set_theme(style="ticks", context="paper", font_scale=1.0) + fig = plt.figure(figsize=(14.5, 10.5), constrained_layout=True) + grid = fig.add_gridspec(2, 2, height_ratios=[1, 1.08]) + + ax = fig.add_subplot(grid[0, 0]) + primary = coupling.loc[coupling.outcome.eq("mechanical_barrier")].copy() + sns.boxplot(data=primary, x="stage_numeric", y="beta", color="#F1C7CE", width=0.58, fliersize=0, ax=ax) + sns.stripplot(data=primary, x="stage_numeric", y="beta", hue="spatial_field_p", palette="viridis_r", size=5, ax=ax) + ax.axhline(0, color="#555", lw=0.8) + ax.set(xlabel="Fibrosis stage", ylabel="Scar-proximity beta") + ax.set_title("A Human scar coupling of the mechanical barrier", loc="left", fontweight="bold") + if ax.legend_: + ax.legend_.remove() + + ax = fig.add_subplot(grid[0, 1]) + order = [ + "mechanical_barrier", "feedback_lock", "clearance_inefficiency", + "antiproteolytic_brake", "protease_activation_potential", + "feedback_core", "proteolysis", + ] + s = summary.set_index("outcome").loc[order].reset_index() + y = np.arange(len(s)) + for yi, row in s.iterrows(): + ax.errorbar( + row["median"], + yi, + xerr=[[row["median"] - row["bootstrap_median_ci_low"]], [row["bootstrap_median_ci_high"] - row["median"]]], + fmt="o", + color=PALETTE[row["outcome"]], + ecolor=PALETTE[row["outcome"]], + capsize=3, + ) + ax.axvline(0, color="#777", lw=0.8) + ax.set_yticks(y, [name.replace("_", " ") for name in s.outcome]) + ax.invert_yaxis() + ax.set_xlabel("Patient-level median scar-proximity beta (95% bootstrap CI)") + ax.set_title("B Scar coupling indicates turnover with an inhibitory brake", loc="left", fontweight="bold") + + ax = fig.add_subplot(grid[1, 0]) + target_order = ["HSC_retention", "TGFb_integrator", "Endo_resolver", "LAM_resolver"] + sns.boxplot(data=cross, y="target", x="partial_r", order=target_order, color="#D7E1E7", fliersize=0, ax=ax) + sns.stripplot(data=cross, y="target", x="partial_r", order=target_order, color="#334E5C", size=3.2, alpha=0.65, ax=ax) + ax.axvline(0, color="#777", lw=0.8) + ax.set(xlabel="Biopsy-level partial correlation", ylabel="") + ax.set_title("C Barrier coupling after lineage and library adjustment", loc="left", fontweight="bold") + + holder = fig.add_subplot(grid[1, 1]) + holder.set_axis_off() + holder.set_title("D Exploratory clearance-inefficiency fields", loc="left", fontweight="bold") + exploratory = coupling.loc[coupling.outcome.eq("clearance_inefficiency")].copy() + representatives = [] + for group in ["early", "intermediate", "late"]: + local = exploratory.loc[exploratory.stage_group.eq(group)] + target = local.beta.median() + representatives.append(local.loc[(local.beta - target).abs().idxmin(), "biopsy_id"]) + positions = [(0.02, 0.08, 0.30, 0.79), (0.35, 0.08, 0.30, 0.79), (0.68, 0.08, 0.30, 0.79)] + for biopsy, position in zip(representatives, positions): + inset = holder.inset_axes(position) + local = data.loc[data.biopsy_id.eq(biopsy)] + inset.scatter( + local.pxl_col_in_fullres, + -local.pxl_row_in_fullres, + c=local.clearance_inefficiency, + cmap="RdBu_r", + vmin=-2.5, + vmax=2.5, + s=5, + linewidths=0, + rasterized=True, + ) + row = local.iloc[0] + inset.set_title(f"{row.stage_group}\n{row.fibrosis_stage} | {biopsy}", fontsize=8) + inset.set_aspect("equal") + inset.set_axis_off() + holder.text(0.5, 0.0, "Blue: activation potential Red: SERPINE1/TIMP-dominant brake", ha="center", fontsize=8) + + for ax in fig.axes[:3]: + ax.spines[["top", "right"]].set_visible(False) + fig.suptitle("Human spatial data refine proteolytic shutdown into clearance inefficiency", fontsize=16, fontweight="bold") + fig.savefig(OUTPUT / "UQ_Visium_spatial_proteolytic_lock.png", dpi=320, facecolor="white") + fig.savefig(OUTPUT / "UQ_Visium_spatial_proteolytic_lock.pdf", facecolor="white") + plt.close(fig) + + +def parse_args() -> argparse.Namespace: + parser=argparse.ArgumentParser(description=__doc__) + parser.add_argument("--source-results",type=Path,default=SOURCE_RESULTS) + parser.add_argument("--visium-dir",type=Path,default=VISIUM) + parser.add_argument("--helper-script",type=Path,default=HELPER) + parser.add_argument("--output-dir",type=Path,default=OUTPUT) + return parser.parse_args() + + +def main() -> None: + global SOURCE_RESULTS,VISIUM,HELPER,OUTPUT + args=parse_args() + SOURCE_RESULTS,VISIUM,HELPER,OUTPUT=args.source_results,args.visium_dir,args.helper_script,args.output_dir + OUTPUT.mkdir(parents=True, exist_ok=True) + helper = load_helper() + base = pd.read_parquet(SOURCE_RESULTS / "UQ_Visium_spot_module_scores.parquet") + data, detection = add_gene_scores(base) + coupling = helper.fit_biopsies(data) + cross = cross_module_correlations(data, helper) + coupling_summary = patient_summary(coupling, "beta", "outcome") + cross_summary = patient_summary(cross, "partial_r", "target") + trends = stage_trends(coupling, cross, data, helper) + coupling_summary["wilcoxon_fdr"] = helper.bh(coupling_summary["wilcoxon_signed_rank_p"]) + cross_summary["wilcoxon_fdr"] = helper.bh(cross_summary["wilcoxon_signed_rank_p"]) + trends["permutation_fdr_within_analysis"] = trends.groupby("analysis", observed=True)[ + "stage_beta_within_array_permutation_p" + ].transform(helper.bh) + + data.to_parquet(OUTPUT / "UQ_proteolytic_lock_spot_scores.parquet", index=False) + detection.to_csv(OUTPUT / "UQ_proteolytic_lock_gene_detection.tsv", sep="\t", index=False) + coupling.to_csv(OUTPUT / "UQ_proteolytic_lock_biopsy_coupling.tsv", sep="\t", index=False) + coupling_summary.to_csv(OUTPUT / "UQ_proteolytic_lock_patient_summary.tsv", sep="\t", index=False) + cross.to_csv(OUTPUT / "UQ_proteolytic_lock_cross_module_correlations.tsv", sep="\t", index=False) + cross_summary.to_csv(OUTPUT / "UQ_proteolytic_lock_cross_module_summary.tsv", sep="\t", index=False) + trends.to_csv(OUTPUT / "UQ_proteolytic_lock_stage_trends.tsv", sep="\t", index=False) + plot_results(data, coupling, cross, coupling_summary) + + primary = coupling_summary.loc[coupling_summary.outcome.eq("mechanical_barrier")].iloc[0] + exploratory = coupling_summary.loc[coupling_summary.outcome.eq("clearance_inefficiency")].iloc[0] + exploratory_trend = trends.loc[ + trends.analysis.eq("scar_coupling") & trends.feature.eq("clearance_inefficiency") + ].iloc[0] + summary = { + "n_spots": int(len(data)), + "n_biopsies": int(data.biopsy_id.nunique()), + "n_patients": int(data.patient_cluster.nunique()), + "n_arrays": int(data.array.nunique()), + "primary_score": "z(SERPINE1)-mean[z(MMP2),z(MMP9)]", + "primary_scar_coupling": primary.to_dict(), + "exploratory_clearance_inefficiency": { + "post_hoc": True, + "score": "mean[z(SERPINE1),z(TIMP1),z(TIMP2)]-mean[z(PLAU),z(PLAT),z(MMP2),z(MMP9),z(MMP14)]", + "scar_coupling": exploratory.to_dict(), + "stage_trend": exploratory_trend.to_dict(), + }, + "claim_boundary": "Spatial association after lineage and library adjustment; not cell-specific causality.", + } + (OUTPUT / "UQ_proteolytic_lock_summary.json").write_text(json.dumps(summary, indent=2, ensure_ascii=False) + "\n") + print(json.dumps(summary, indent=2, ensure_ascii=False)) + + +if __name__ == "__main__": + main() diff --git a/data/LINCS_derived/LINCS_name_collapsed_hard_gated.tsv b/data/LINCS_derived/LINCS_name_collapsed_hard_gated.tsv new file mode 100644 index 0000000..51d1355 --- /dev/null +++ b/data/LINCS_derived/LINCS_name_collapsed_hard_gated.tsv @@ -0,0 +1,576 @@ +pert_iname_norm pert_iname pert_ids n_signatures n_cell_lines cell_lines median_retention_suppression q25_retention_suppression median_endo_support median_macro_support median_resolver_floor median_dual_control q25_dual_control fraction_dual_positive n_pert_ids min_id_retention max_id_retention min_id_resolver_floor max_id_resolver_floor retention_direction_conflict_across_ids resolver_direction_conflict_across_ids robust_dual concurrent_score early_score late_score concurrent_rank median_sensitivity_rank worst_sensitivity_rank n_top50_schemes is_touchstone has_structure pubchem_cids named_identity identity_resolved duplicate_id_conflict safety_gate mechanism_context computational_hard_gate translation_tier +dacinostat dacinostat BRD-K56957086 4 2 HEPG2;PHH 0.0418203498961197 0.0008960107548369248 0.13159527310303276 0.1436075223609805 0.0497764819966895 0.18093008946420414 0.0243070255373678 0.75 1 0.0418203498961197 0.0418203498961197 0.0497764819966895 0.0497764819966895 False False 0.19308360223288804 5.222467318254684 1.024246283943957 0.5817157146170637 9 155.0 175 0 1 True 6445533 True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +prochlorperazine prochlorperazine BRD-K19352500 3 2 HEPG2;PHH 0.0186749911970562 -0.0008714991725153505 0.5047345033713749 0.1738750021904707 0.148764285658087 0.3037168638603318 0.29211770705435247 0.6666666666666666 1 0.0186749911970562 0.0186749911970562 0.148764285658087 0.148764285658087 False False 0.44977571738750804 5.193776824072043 2.4835161945213544 0.4263738366866162 11 47.0 171 3 1 True True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated True Excluded_safety +panobinostat panobinostat BRD-K02130563 7 2 HEPG2;PHH 0.0823826835387283 -0.1212855792707867 0.4303749033382961 0.5868699364364147 0.4303749033382961 0.4924273421943542 0.31596310812211226 0.5714285714285714 1 0.0823826835387283 0.0823826835387283 0.4303749033382961 0.4303749033382961 False False 0.6504088962554103 5.0008070392663315 4.2164036292646205 0.4621845328639788 15 9.0 51 4 1 True 6918837 True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated True Excluded_safety +terfenadine terfenadine BRD-A06352418 3 2 HEPG2;PHH 0.0787223801016807 -0.03821520590119895 0.1088928447238036 0.0061750006861984 0.0061750006861984 0.2491889264700668 -0.5311899541374592 0.6666666666666666 1 0.0787223801016807 0.0787223801016807 0.0061750006861984 0.0061750006861984 False False -0.01640605059866279 4.388493623142532 0.43395810718368066 0.6982668916572825 22 185.0 276 0 1 True True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +menadione menadione BRD-K78126613 4 2 HEPG2;PHH -0.1429788004348262 -0.5192025662529178 0.3164527213999203 0.25278845988214016 0.23732967634818383 0.19749318212196826 -0.32330678088686593 0.5 1 -0.1429788004348262 -0.1429788004348262 0.23732967634818383 0.23732967634818383 False False 0.03583979167853529 3.5345413771965957 2.3831560941048107 -2.240880116494065 31 179.0 392 0 1 True True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +geldanamycin geldanamycin BRD-A19500257 35 3 HEPG2;HUH7;PHH 0.2312507074740198 0.0309788017637199 0.4041338435241154 0.2079828307032585 0.1065098238842827 0.3454009828615993 -0.21644695727006774 0.42857142857142855 1 0.2312507074740198 0.2312507074740198 0.1065098238842827 0.1065098238842827 False False 0.23717750422656544 3.477674577276362 2.176621694134193 1.901928676501215 32 20.0 30 5 1 True 5288382 True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +ouabain ouabain BRD-A46747628;BRD-A68930007;BRD-K35708212 7 2 HEPG2;PHH 0.1288166551126374 -0.1269290016757117 0.1778428511960166 0.2575500067323446 -0.0488910973072052 0.1962746299271072 -0.14663403052540996 0.14285714285714285 3 -0.169300228357315 0.3127004644936985 -0.2297251777989523 0.1915428532021386 True True 0.12295761466440222 1.6617392742859587 1.2506929814950014 0.7450930480382244 145 59.0 91 2 1 True 439501 True True True exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +digoxin digoxin BRD-A94756469;BRD-K23478508 5 2 HEPG2;PHH -0.2088537000947528 -0.2424627881911066 0.4839931343282972 0.6180186588317156 0.36039450019598 0.384522095026951 0.285989594527535 0.0 2 -0.2088537000947528 -0.14629266162713364 0.3550915208512119 0.36039450019598 False False 0.5275168922907185 1.551259844599329 4.290767959379218 -1.8018625895605687 151 52.0 356 2 1 True 30322;73707466 True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +alvocidib alvocidib BRD-K87909389 3 2 HEPG2;PHH -0.4633889454934332 -0.5538215301930904 1.1669247363294877 0.7276575677096844 0.7276575677096844 0.3623919347153297 0.3239225000143051 0.0 1 -0.4633889454934332 -0.4633889454934332 0.7276575677096844 0.7276575677096844 False False 0.5243531847224823 1.545794850615631 7.599862853723048 -4.423080481543519 152 14.0 488 3 1 True 5287969 True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +aminopurvalanol-a aminopurvalanol-a BRD-K07762753 13 3 HEPG2;HUH7;PHH -0.4394389018416405 -0.925781797617674 0.936057720865522 0.7590625323355198 0.7443279027938843 0.2945362848362752 0.0678264410678474 0.0 1 -0.4394389018416405 -0.4394389018416405 0.7443279027938843 0.7443279027938843 False False 0.3284495053701989 1.2073904924525825 7.046214621190847 -5.431238025185862 183 32.0 496 3 1 True True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +doxorubicin doxorubicin BRD-A52530684;BRD-K92093830 11 2 HEPG2;PHH -0.5563972045977911 -0.9224659950058494 0.6325040991817202 0.851612526923418 0.5959352105855942 0.2565840770978302 -0.0367098011386891 0.0 2 -0.5563972045977911 -0.5207569420777468 0.2993245654340301 0.6325040991817202 False False 0.23822917652848566 1.0515437387015365 6.035735997780269 -6.1779131683761594 209 133.0 561 1 1 True True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +thiostrepton thiostrepton BRD-A20697603 3 2 HEPG2;PHH -0.0688117179605695 -0.5015461912585628 0.4601235432284219 0.4335254803299904 0.4335254803299904 0.1304218468019768 0.07967164809815586 0.0 1 -0.0688117179605695 -0.0688117179605695 0.4335254803299904 0.4335254803299904 False False 0.17025767085105473 0.9341296409765828 3.8549695031365783 -1.7055992691756159 225 51.0 186 2 1 True 16129995;73707520 True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +proscillaridin proscillaridin BRD-A34806832 3 2 HEPG2;PHH -0.2359194482366244 -0.4676930582564738 0.5250661287988935 0.4303891714662313 0.4303891714662313 0.115793039833772 0.08922658588123755 0.0 1 -0.2359194482366244 -0.2359194482366244 0.4303891714662313 0.4303891714662313 False False 0.16040633277439076 0.9171124223622975 4.031717594847846 -2.681384892615845 228 101.0 421 1 1 True True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +mitoxantrone mitoxantrone BRD-K21680192 12 3 HEPG2;HUH7;PHH -0.4020279803209834 -0.86921102543258 0.8253790991646903 0.3194843409582972 0.1658730969897338 0.02458009984905995 -0.31979559859517764 0.08333333333333333 1 -0.4020279803209834 -0.4020279803209834 0.1658730969897338 0.1658730969897338 False False -0.13531769944852887 0.8783791147713175 3.9211769957199416 -5.012179663479662 236 144.0 528 1 1 True True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +daunorubicin daunorubicin BRD-A68009927;BRD-K17210248;BRD-K43389675 7 2 HEPG2;PHH -0.6019518747925758 -0.9376429124062673 1.0600857138633728 0.7591437427327037 0.5354925245046616 0.025579403649779 0.0039992433758305 0.0 3 -0.9895524833247892 -0.3825888923472828 0.2934500121045857 0.8805753253400326 False False 0.027579025337694248 0.6876662993070426 6.882923292397851 -6.520238780060372 257 66.0 560 2 1 True 12309103;2958;46931007 True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +triclosan triclosan BRD-K41731458 3 2 HEPG2;PHH -0.5485333235313495 -0.6494560675022917 0.4694142746073859 0.4962542206048965 0.4694142746073859 -0.2069706198434153 -0.38871487223779755 0.0 1 -0.5485333235313495 -0.5485333235313495 0.4694142746073859 0.4694142746073859 False False -0.4013280559623141 -0.053228542682682456 4.162099091643294 -5.273265322414287 379 415.0 569 0 1 True True True False exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +cyclosporin-a cyclosporin-a BRD-A38030642;BRD-A64290322;BRD-A69815203;BRD-K13533483 9 2 HEPG2;PHH -0.0557719253831439 -0.1988489725109603 -0.11048367193767 0.1891020014882087 -0.1528996713459491 -0.1594022081588351 -0.51451192060042 0.0 4 -0.32255524138195646 0.10767144777087695 -0.22424040734767908 0.1891020014882087 True True -0.4166581684590451 -0.07970980580737688 -0.0820139988552334 -0.6746119167501481 382 362.0 449 0 1 True 16404350;5284373 True True True exclude_narrow_margin_or_cytotoxic unresolved_or_not_curated False Excluded_safety +wz-4002 WZ-4002 BRD-K72420232 4 2 HEPG2;PHH 0.3318178856538402 0.17990509017060197 0.2535583270447595 0.23203410161659122 0.1696766402040209 0.524433414692 -0.10182169676455302 0.75 1 0.3318178856538402 0.3318178856538402 0.1696766402040209 0.1696766402040209 False False 0.4735225663097235 5.706898075023038 1.9599890247309875 3.018593789307171 4 10.0 24 5 1 True 44607530 True True False mechanistic_probe_only EGFR-family kinase probe; tests growth-factor input into the retention attractor True Tier_1_mechanistic_probe +verteporfin verteporfin BRD-M45964048 3 2 HEPG2;PHH 0.3174578201853567 0.1837441553879115 0.2116477851356779 0.0395371671766042 0.0395371671766042 0.5588061455489388 0.06401566066409631 0.6666666666666666 1 0.3174578201853567 0.3174578201853567 0.0395371671766042 0.0395371671766042 False False 0.5908139758809869 5.437406558335957 0.9262458198629218 2.937649773036116 6 23.0 58 3 1 True 11980942 True True False mechanistic_probe_only YAP/TEAD-mechanotransduction probe; independent HSC fibrosis evidence True Tier_1_mechanistic_probe +pre-084 PRE-084 BRD-K57304726 3 2 HEPG2;PHH 0.1047722188134988 0.06850122701790595 0.5425642643656049 0.1495749969035387 0.1495749969035387 0.4508418494480706 0.14556920642979326 0.6666666666666666 1 0.1047722188134988 0.1047722188134988 0.1495749969035387 0.1495749969035387 False False 0.5236264526629673 5.321346713281833 2.5260382596153486 1.2006012697266555 7 25.0 111 3 1 True True True False mechanistic_probe_only sigma-1 receptor probe; liver mechanism unresolved True Tier_1_mechanistic_probe +tyrphostin-1 tyrphostin-1 BRD-K41996876 3 2 HEPG2;PHH 0.2134195044636726 0.165535744279623 0.1507142931222915 0.2187437564134597 0.1507142931222915 0.5313515474886766 -0.11645787764739779 0.6666666666666666 1 0.2134195044636726 0.2134195044636726 0.1507142931222915 0.1507142931222915 False False 0.47312260866497774 5.234106284876336 1.56428358984996 2.207292994011233 8 41.0 66 3 1 True True True False mechanistic_probe_only broad receptor-tyrosine-kinase probe True Tier_1_mechanistic_probe +oxfendazole oxfendazole BRD-A33447119 3 2 HEPG2;PHH 0.1823611193233066 0.17575834525956047 0.1390857100486755 0.1529172277078032 0.1164587789348193 0.3215597023012205 0.26279782169934596 0.6666666666666666 1 0.1823611193233066 0.1823611193233066 0.1164587789348193 0.1164587789348193 False False 0.4529586131508935 5.199274963777584 1.2450827882545723 2.0382269557396553 10 63.0 82 0 1 True True True False translation_review named repurposing candidate; mechanism and exposure review required False Tier_2_translation_anchor +dehydrocholate dehydrocholate BRD-A64125466 3 2 HEPG2;PHH 0.1285866532060835 0.0915572169340319 0.3431857185704367 0.1244734413921833 0.0620308773858206 0.4008099704699975 0.03355280549768064 0.6666666666666666 1 0.1285866532060835 0.1285866532060835 0.0620308773858206 0.0620308773858206 False False 0.41758637321883785 5.138172894686419 1.6309568382064117 1.426846483949817 12 53.0 116 2 1 True True True False translation_review bile-acid-context candidate; formulation and mechanism review required True Tier_2_translation_anchor +pioglitazone pioglitazone BRD-A48430263 3 2 HEPG2;PHH 0.0744920210498902 0.03765156570201115 0.1430142798594066 0.2565000038594007 0.1430142798594066 0.2005682522135358 0.1587396111516725 0.6666666666666666 1 0.0744920210498902 0.0744920210498902 0.1430142798594066 0.1430142798594066 False False 0.2799380577893721 4.90039895399708 1.634436950116657 0.9081325691311279 16 79.0 122 0 1 True True True False translation_review PPAR-gamma re-quiescence/metabolic anchor False Tier_2_translation_anchor +psb-069 PSB-069 BRD-K79366068 3 2 HEPG2;PHH 0.4291111048724916 0.35651184579667944 0.0297714109931673 0.2435254864394664 0.0297714109931673 0.791133112813686 0.17288818184862886 0.6666666666666666 1 0.4291111048724916 0.4291111048724916 0.0297714109931673 0.0297714109931673 False False 0.8775772037380005 5.932761859413336 0.9673640184921087 4.200628672561935 2 8.0 38 5 1 True True True False manual_review_required unresolved_or_not_curated True Tier_3_computational_hit +y-26763 Y-26763 BRD-K45117373 3 2 HEPG2;PHH 0.0190958171668979 -0.04166459302521415 0.7314142712524959 0.1104624923318624 0.1104624923318624 0.5422828206496816 0.23510033493151977 0.6666666666666666 1 0.0190958171668979 0.0190958171668979 0.1104624923318624 0.1104624923318624 False False 0.6598329881154414 5.55663012071861 2.8736127698234353 0.30153106158441767 5 21.0 233 3 1 True True True False manual_review_required unresolved_or_not_curated True Tier_3_computational_hit +brd-k78062244 BRD-K78062244 BRD-K78062244 3 2 HEPG2;PHH 0.1072504143748018 0.0429324878172742 0.8654840929167611 0.197705453261733 0.197705453261733 0.6956984300964645 0.6256057801730339 0.6666666666666666 1 0.1072504143748018 0.1072504143748018 0.197705453261733 0.197705453261733 False False 1.0085013201829813 6.158920407022624 3.758454815706069 1.136684425099371 1 6.0 78 4 0 True 6545175 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fluphenazine fluphenazine BRD-K53987533;BRD-K55127134 3 2 HEPG2;PHH 0.1243361118766996 -0.1394722203517126 0.393835717013904 0.5218250118196011 0.393835717013904 0.5359248185293779 0.5101092632135583 0.6666666666666666 2 -0.13947222035171258 0.2155527714639902 0.393835717013904 0.5027285777032375 True False 0.7909794501361571 5.783172748464093 3.8192251762718294 0.6768668230002531 3 10.0 39 5 1 True 9550045 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tolazamide tolazamide BRD-K32164935 3 2 HEPG2;PHH 0.0826314886411031 0.0807579101787673 0.0982233562639781 0.2166481369640678 0.0982233562639781 0.3161777444922971 0.18588139767950718 0.6666666666666666 1 0.0826314886411031 0.0826314886411031 0.0982233562639781 0.0982233562639781 False False 0.40911844333205066 5.123545377797597 1.2667926191841408 1.0956180696692681 13 105.0 149 0 1 True 5503 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +norethisterone norethisterone BRD-A39415247;BRD-K92073408 3 2 HEPG2;PHH 0.086446759601434 -0.0937433859540357 0.5049031249114445 0.1826546504162252 0.1826546504162252 0.2379600993165421 0.22477001321339415 0.6666666666666666 2 -0.0855621517532402 0.086446759601434 0.1593171618878841 0.1826546504162252 True False 0.3503451059232392 5.022020212018737 2.5969785222677513 0.5746193116159791 14 30.0 101 3 1 True 5702093;6230 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gr-113808 GR-113808 BRD-K49945136 3 2 HEPG2;PHH 0.130313897298442 0.09494444438152841 0.1243499943188258 0.0663125030696392 0.0663125030696392 0.2256451459926745 0.1013047074130367 0.6666666666666666 1 0.130313897298442 0.130313897298442 0.0663125030696392 0.0663125030696392 False False 0.2762974996991928 4.894110247588217 0.8138180229495693 1.448618952734183 17 112.0 164 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gbr-12783 GBR-12783 BRD-K34034388;BRD-K92015269 3 2 HEPG2;PHH 0.2707820265657372 0.1409497017868691 0.2082190534898213 0.3051418904215097 0.2082190534898213 0.3294947808164926 -0.20088156522621242 0.6666666666666666 2 0.19432905802710188 0.2707820265657372 -0.4745668194123676 0.2566804719556655 False True 0.22905399820338637 4.812501740520241 2.141617923330496 2.501702828801528 18 19.0 33 5 1 True 5788723 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +noretynodrel noretynodrel BRD-A00758722;BRD-K80334323 3 2 HEPG2;PHH 0.1771500149948729 0.13784028331024775 0.2728619213615145 0.0559541760012507 0.0559541760012507 0.3763652007568568 -0.5475758120476728 0.6666666666666666 2 0.1771500149948729 0.24176065168446959 -0.3373654862599714 0.0559541760012507 False True 0.10257729473302041 4.594025661857614 1.2003317044195727 1.885920686376618 19 60.0 132 1 1 True 5702095;6231;7061273 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pergolide pergolide BRD-K60770992 3 2 HEPG2;PHH 0.0323305676380793 0.02691210164792005 0.1394507991416113 0.2421250343322754 0.1394507991416113 0.2323502209924516 -0.338086283810082 0.6666666666666666 1 0.0323305676380793 0.0323305676380793 0.1394507991416113 0.1394507991416113 False False 0.0633070790874106 4.52619022270499 1.5716917285854217 0.6016471127654947 20 114.0 165 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +vincristine vincristine BRD-A60414806;BRD-A76528577 3 2 HEPG2;PHH 0.0908861193392011 0.02949444784058465 0.0440428512437003 0.1582312472164631 0.0440428512437003 0.193546082765337 -0.2783891915358485 0.6666666666666666 2 0.0497902776632044 0.0908861193392011 -0.17736429082495825 0.2830500043928623 False True 0.05435148699741274 4.510720317273883 0.7915528116761916 0.9887391544047632 21 136.0 186 0 1 True 24058669;5022426;5388992;6324671 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k41172353 BRD-K41172353 BRD-K41172353 12 3 HEPG2;HUH7;PHH 0.1116012223064899 -0.17448765494757223 0.3327827884682587 0.700984176248312 0.22701601258346016 0.4965592959659203 0.2963275890972923 0.4166666666666667 1 0.1116012223064899 0.1116012223064899 0.22701601258346016 0.22701601258346016 False False 0.6447230905145664 4.1142265493539 3.7454880180462724 0.48493781282177295 23 7.0 44 5 0 True 673329 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gdc-0941 GDC-0941 BRD-K52911425 4 2 HEPG2;PHH 0.020038250523308897 -0.0199786485172808 0.14543799843106947 0.32953458442352707 0.050225634526993496 0.2575245419506072 0.14598527873334077 0.5 1 0.020038250523308897 0.020038250523308897 0.050225634526993496 0.050225634526993496 False False 0.3305171813172776 4.043567615170103 1.6226160228998632 0.3754467158156463 24 90.0 160 0 1 True 17755052 True True False mechanistic_probe_only PI3K pathway probe False Tier_4_not_prioritized +ag-490 AG-490 BRD-K12357156;BRD-K47105409 4 2 HEPG2;PHH -0.061314900302224695 -0.3058142845208446 0.28224956563540865 0.39936948381364346 0.2174672408561621 0.36288505776356605 -0.21283392859844583 0.5 2 -0.07189392484724524 -0.061314900302224695 0.041165707233761034 0.46617948583194185 False False 0.2564680934643431 3.915655091371252 2.6682951078262267 -1.0449883664039261 25 77.0 233 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +r(-)-propylnorapomorphine r(-)-propylnorapomorphine BRD-K13544237 3 2 HEPG2;PHH -0.0806753974821832 -0.18439834639947444 0.2418594307133129 0.7916333414614201 0.2317333327872412 0.5774252299138064 0.20982796538968584 0.3333333333333333 1 -0.0806753974821832 -0.0806753974821832 0.2317333327872412 0.2317333327872412 False False 0.6823392126086494 3.707103801802152 3.7567379308635473 -0.7906168911568439 26 22.0 170 3 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +u-0126 U-0126 BRD-K18787491;BRD-K91701654 16 3 HEPG2;HUH7;PHH 0.0946428860641188 0.0157433682017856 0.14443383631961684 0.183947111479938 0.010784115110124849 0.16860948396488162 -0.09756857955030027 0.5 2 0.0946428860641188 0.16602620854973796 -0.3983759858778545 0.0308613762525575 False True 0.11982519418973149 3.6796179083053278 1.0834597605085847 0.970053963666875 27 91.0 116 0 1 True 3006531;5354033 True True True mechanistic_probe_only MEK-ERK/AP-1 pathway probe False Tier_4_not_prioritized +rs-39604 RS-39604 BRD-K20742498 3 2 HEPG2;PHH 0.2354541489233573 0.1837479063413209 0.1898714361180152 -0.0045319534838199 -0.1698943163667406 0.535246127248106 0.2143228333480361 0.3333333333333333 1 0.2354541489233573 0.2354541489233573 -0.1698943163667406 -0.1698943163667406 False False 0.6424075439221241 3.6381257675103953 0.193551477434098 2.4068705942978186 28 57.0 133 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +aliskiren aliskiren BRD-K30020243 3 2 HEPG2;PHH 0.4764824906984965 0.2830468008501662 0.0255714314324515 -0.0147318169474601 -0.0147318169474601 0.5497612852957987 0.16343575297662666 0.3333333333333333 1 0.4764824906984965 0.4764824906984965 -0.0147318169474601 -0.0147318169474601 False False 0.631479161784112 3.619248061101808 0.06887154876739829 4.2775155343430695 29 25.0 71 4 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nsc-632839 NSC-632839 BRD-K37392901;BRD-K74402642 15 3 HEPG2;HUH7;PHH 0.1132611094249619 0.05013780564897585 0.1902502030134201 0.3623399175703525 0.1902502030134201 0.3938085539118637 -0.4077525977636613 0.4666666666666667 2 0.0716323140594694 0.16119946984367234 -0.2601836685623441 0.20176455564796925 False True 0.18993225503003305 3.611880606706878 2.212920594748267 1.1981224809094182 30 42.0 92 3 1 True 6477762 True True True mechanistic_probe_only deubiquitinase-pathway probe; toxicity gate required False Tier_4_not_prioritized +bibx-1382 BIBX-1382 BRD-K70914287 3 2 HEPG2;PHH 0.0958000073830286 -0.06717419914073416 0.2576059762920652 0.2544375136494636 0.2144357274685587 0.3984232026906241 0.28052690761193394 0.3333333333333333 1 0.0958000073830286 0.0958000073830286 0.2144357274685587 0.2144357274685587 False False 0.5386866564965911 3.4589581252619745 2.1535851712817706 0.718246932061949 33 54.0 90 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tubocurarine tubocurarine BRD-K02607075;BRD-K99621550 4 2 HEPG2;PHH 0.22219801445802054 0.11284840313924682 -0.0646910603557314 0.015834821388125433 -0.0646910603557314 0.11443980831268527 -0.4930531865554965 0.5 2 0.149452768266201 0.30094704777002335 -0.1166049089016659 -0.0344823650749666 False False -0.132086784965063 3.2444647151579735 -0.237416359233037 2.099352326781365 34 126.0 219 0 1 True 6713947 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rhamnetin rhamnetin BRD-K37206356 3 2 HEPG2;PHH -0.1832732118976613 -0.3410032666547017 0.6455573503460202 0.3307749945670366 0.3307749945670366 0.3110339619174954 0.16787621369659303 0.3333333333333333 1 -0.1832732118976613 -0.1832732118976613 0.3307749945670366 0.3307749945670366 False False 0.3949720687657919 3.210705295195149 3.8392599686004805 -1.9444381846614376 35 68.0 347 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rutin rutin BRD-A34907681;BRD-K20482099 5 2 HEPG2;PHH 0.1631370389627086 0.0753427313433753 -0.0944963672331401 0.0522606917656958 -0.0944963672331401 0.1843693222377508 -0.1134658092558975 0.4 2 -0.0393086971922053 0.1631370389627086 -0.32129550888203084 -0.0944963672331401 True False 0.12763641760980204 3.1265899461611597 -0.2938830444732535 1.5997778348564196 36 177.0 264 0 1 True 5293655 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ticlopidine ticlopidine BRD-K00603606 3 2 HEPG2;PHH -0.017839344839255 -0.09134745101133979 0.346075747694288 0.1962749878875911 0.1225165724754333 0.2337006829856407 0.22507874911562314 0.3333333333333333 1 -0.017839344839255 -0.017839344839255 0.1225165724754333 0.1225165724754333 False False 0.3462400575434523 3.1265255338235667 2.0090078451473246 -0.09290818249818347 37 95.0 198 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +l-755507 L-755507 BRD-A93206962 3 2 HEPG2;PHH 0.0719694246848424 0.0716444353262583 -0.0552500145775931 0.1757347541861236 -0.0552500145775931 0.2645270127049159 0.11654477654254092 0.3333333333333333 1 0.0719694246848424 0.0719694246848424 -0.0552500145775931 -0.0552500145775931 False False 0.32279940097618637 3.086034102693773 0.2929915646947229 0.9981056529534822 38 190.0 280 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nvp-tae684 NVP-TAE684 BRD-K50140147 5 2 HEPG2;PHH 0.3068421044283443 0.1615088503393862 0.1419794602053506 0.206894633360207 0.1419794602053506 0.0904138987026517 0.019557782249259 0.4 1 0.3068421044283443 0.3068421044283443 0.1419794602053506 0.1419794602053506 False False 0.10019278982728119 3.0791837755567313 1.4803982138948242 2.7994032456748315 39 16.0 43 5 1 True 16038120 True True False mechanistic_probe_only oncology kinase probe; experimental use only False Tier_4_not_prioritized +nu-7026 NU-7026 BRD-K09537769 3 2 HEPG2;PHH 0.0272444321049584 -0.010497229380740051 0.3177923911384174 0.1415750132873654 0.121435706104551 0.2075846081614376 0.20573438439030373 0.3333333333333333 1 0.0272444321049584 0.0272444321049584 0.121435706104551 0.121435706104551 False False 0.3104518003565895 3.0647048357992275 1.7581600552143564 0.4517406225796001 40 92.0 186 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +etomoxir etomoxir BRD-K32405725;BRD-K77625572 3 2 HEPG2;PHH 0.2536740799744924 0.0590975077615844 0.055091449192592 0.1128125116229057 0.0046254955232143 0.2679031282249424 0.081141268065761 0.3333333333333333 2 0.059097507761584386 0.3190087392512295 -0.1012920439243316 0.05871900357306 False True 0.30847376225782286 3.0612879693297037 0.5879494662237649 2.1350018092191334 41 54.0 92 2 1 True 123823;14249524;9840324 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +loperamide loperamide BRD-K61250553 3 2 HEPG2;PHH 0.2002627576390902 0.03549115525351629 0.4623974221093314 0.1086321733891964 0.1086321733891964 0.2541456246778132 0.04811022794317635 0.3333333333333333 1 0.2002627576390902 0.2002627576390902 0.1086321733891964 0.1086321733891964 False False 0.27820073864940137 3.008994295429682 2.0592202618733775 1.7154616707420802 42 28.0 74 4 1 True 71420 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +digitoxin digitoxin BRD-A93236127 3 2 HEPG2;PHH 0.0826944433566596 -0.143573420536187 0.6051721487726484 0.0462874863296747 0.0462874863296747 0.1786486358337459 0.16537555239148555 0.3333333333333333 1 0.0826944433566596 0.0826944433566596 0.0462874863296747 0.0462874863296747 False False 0.26133641202948865 2.9798628281467168 2.140155759729121 0.39450475293914156 43 34.0 234 3 1 True 73707526 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +apigenin apigenin BRD-K01493881;BRD-K12057390 7 2 HEPG2;PHH 0.0341018281049198 -0.049766499031749054 0.0593049973249435 0.1420576111413538 0.0460132722343717 0.1396941612844192 -0.3917846333693772 0.42857142857142855 2 0.0299724928206867 0.052879444633920955 -0.1243634511317526 0.0978082375867026 False True -0.0561981554002694 2.970896950000916 0.7938693446885171 0.37332553311455935 44 188.0 220 0 1 True 5280443 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +malonoben malonoben BRD-K38477985 13 3 HEPG2;HUH7;PHH 0.0918104764488008 -0.0664305488268534 0.1107872873544693 0.4231870509684086 0.0447393364406057 0.2958654559232176 -0.41940871275784 0.38461538461538464 1 0.0918104764488008 0.0918104764488008 0.0447393364406057 0.0447393364406057 False False 0.08616109954429763 2.967788319520786 1.7849672486468018 0.6947491319698437 45 47.0 134 3 1 True 16759147 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +arcyriaflavin-a arcyriaflavin-a BRD-K72726508 3 2 HEPG2;PHH 0.176811108055214 0.01702754176221785 0.3669357214655195 0.135857936926186 0.135857936926186 0.1725136560964442 0.1553061375438812 0.3333333333333333 1 0.176811108055214 0.176811108055214 0.135857936926186 0.135857936926186 False False 0.2501667248683848 2.9605682910194266 1.9248851248778247 1.5059257923067568 46 39.0 73 4 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rilmenidine rilmenidine BRD-K01638814;BRD-M62162320 3 2 HEPG2;PHH 0.1728532032834159 0.10575160249653791 -0.0326952444655554 0.2478398997336626 -0.0326952444655554 0.2270845388771877 0.03886496137812856 0.3333333333333333 2 0.10575160249653791 0.3568769858943091 -0.2211747680391584 0.10757232763405361 False True 0.246517019566252 2.954263783700646 0.6336896367191936 1.7577618523386747 47 76.0 184 1 1 True 5388964;73707355 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +leucodin leucodin BRD-K96119599 3 2 HEPG2;PHH 0.3289481637378533 0.0881342724379566 0.0156380965241364 0.0698083639144897 0.0156380965241364 0.3716713939571664 -0.25992332523067796 0.3333333333333333 1 0.3289481637378533 0.3289481637378533 0.0156380965241364 0.0156380965241364 False False 0.24170973134182744 2.945959665618383 0.3696157289327867 2.7130363635567094 48 43.0 99 3 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +anthothecol anthothecol BRD-A37828317 11 3 HEPG2;HUH7;PHH 0.1026599943223926 -0.07268386727405915 0.2845623620918819 0.4037724547088146 -0.0437081285885402 0.4408085008580533 -0.5985949764264717 0.36363636363636365 1 0.1026599943223926 0.1026599943223926 -0.0437081285885402 -0.0437081285885402 False False 0.1415110126448174 2.9445492792838293 2.0201350906879063 0.7454204156429036 49 27.0 67 3 0 True 73707348 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cabergoline cabergoline BRD-A63043573;BRD-K86882815 3 2 HEPG2;PHH -0.0376499102761348 -0.14786179229203195 0.1342892263616834 0.0450768740847706 0.000360369682312 0.2104990572210341 0.011988290301006649 0.3333333333333333 2 -0.2580736743079291 0.1081127192204197 0.000360369682312 0.024291862334523892 True False 0.2164932023715374 2.9024005893952873 0.6113033860643118 -0.3978670175285577 50 285.0 357 0 1 True True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +diflunisal diflunisal BRD-K22031190 3 2 HEPG2;PHH -0.069132562726736 -0.0868406678653425 0.3599526967321123 5.014613270759583e-05 5.014613270759583e-05 0.200189474570964 0.030964941946819202 0.3333333333333333 1 -0.069132562726736 -0.069132562726736 5.014613270759583e-05 5.014613270759583e-05 False False 0.2156719455443736 2.900981948916445 1.150531125657504 -0.4108239388516756 51 207.0 438 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +trimetozine trimetozine BRD-K53220666 3 2 HEPG2;PHH 0.0778777649005254 -0.047908339584763635 0.1790619024208613 0.0993833243846893 0.0993833243846893 0.1693280254535022 0.0674280973931124 0.3333333333333333 1 0.0778777649005254 0.0778777649005254 0.0993833243846893 0.0993833243846893 False False 0.2030420741500584 2.8791650869922263 1.1608625637345544 0.662487875269609 52 119.0 181 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ubenimex ubenimex BRD-K59574735 3 2 HEPG2;PHH -0.1906684881283177 -0.20143839696215254 0.1819771485669272 0.1720514204353094 0.1354305269196629 0.2000292478986676 -0.016048397196249786 0.3333333333333333 1 -0.1906684881283177 -0.1906684881283177 0.1354305269196629 0.1354305269196629 False False 0.1920050493005427 2.8600997109738744 1.4790517992653127 -1.5558639042985414 53 358.0 476 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fraxetin fraxetin BRD-K76587808 3 2 HEPG2;PHH -0.0056852671421236 -0.0606384710926148 0.3417906633445194 0.0039166063070297 -0.0743702586208071 0.1913240185037019 -0.035524935313751754 0.3333333333333333 1 -0.0056852671421236 -0.0056852671421236 -0.0743702586208071 -0.0743702586208071 False False 0.173561550846826 2.828240379504721 0.9173836016349226 0.08179437696499299 54 150.0 368 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rosiglitazone rosiglitazone BRD-A97437073 3 2 HEPG2;PHH -0.0067228716280725 -0.0438694327862726 0.2482067431722368 0.2748724650591612 0.0743025764822959 0.1545317881991939 0.03621060894210899 0.3333333333333333 1 -0.0067228716280725 -0.0067228716280725 0.0743025764822959 0.0743025764822959 False False 0.17263709267024838 2.826643468834499 1.8280355829797097 0.12751773062662114 55 102.0 185 0 1 True 77999 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +primidone primidone BRD-K32247306 3 2 HEPG2;PHH 0.1555944441093338 0.04704444441530439 -0.0512357056140899 0.0698850862681865 -0.0512357056140899 0.3317809481292016 -0.3695372931718352 0.3333333333333333 1 0.1555944441093338 0.1555944441093338 -0.0512357056140899 -0.0512357056140899 False False 0.147012301543284 2.782379159848301 -0.0011787951979433664 1.4624629752627074 56 153.0 218 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k69516039 BRD-K69516039 BRD-K69516039 3 2 HEPG2;PHH -0.0132207166817453 -0.10694783926010129 0.1078368127346038 0.2340820743702352 0.1078368127346038 0.1577387268706742 -0.03912400206484429 0.3333333333333333 1 -0.0132207166817453 -0.0132207166817453 0.1078368127346038 0.1078368127346038 False False 0.13817672583825205 2.7671165709303787 1.3722487518233497 -0.11179783322493231 57 163.0 246 0 0 True 17460708 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ryuvidine ryuvidine BRD-K06426971 12 3 HEPG2;HUH7;PHH -0.15449408648742566 -0.250498425318963 0.4273323624261788 0.4026112016290426 0.14158151391893625 0.29139375000719037 0.22767240722988924 0.25 1 -0.15449408648742566 -0.15449408648742566 0.14158151391893625 0.14158151391893625 False False 0.405229953622135 2.756323880815296 2.9175583357267474 -1.4751340630775145 58 100.0 339 1 1 True 481747 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +staurosporine staurosporine BRD-K17953061;BRD-K70549064 9 2 HEPG2;PHH -0.4922916773292753 -0.7996908268994756 1.1304699523108346 0.7444062661379576 0.7444062661379576 0.3790816810159456 0.2295553047978689 0.2222222222222222 2 -0.6469500164190928 -0.4376342160006364 0.35557101254484486 0.8170234858989716 False False 0.49385933341488003 2.7520554588607506 7.583803467971089 -5.37903477386145 59 19.0 510 3 1 True 44259;6610353 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +lobendazole lobendazole BRD-K15834839 3 2 HEPG2;PHH -0.1055666671858893 -0.13256045037673575 0.3101785438401358 0.0480562262237072 0.0480562262237072 0.1375675798201608 -0.022757588080056596 0.3333333333333333 1 -0.1055666671858893 -0.1055666671858893 0.0480562262237072 0.0480562262237072 False False 0.12618878578013248 2.7464085823184345 1.2680726109850027 -0.7896267666318192 60 259.0 430 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cyclopamine cyclopamine BRD-A02333338;BRD-K58938839 3 2 HEPG2;PHH -0.5766409635543823 -0.662220624792907 0.4488088658877781 0.1783616691827774 0.1783616691827774 0.3561852191471391 -0.48065354620357836 0.3333333333333333 2 -0.7478002860314317 -0.2630476917450627 -0.10585740155407361 0.8191567994654179 False True 0.1158584460453499 2.728563935402595 2.405464297081311 -5.495116474358916 61 537.0 573 0 1 True 44118238;442972 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +prednisolone-acetate prednisolone-acetate BRD-A01643550 3 2 HEPG2;PHH 0.0857388911147912 -0.06749921170477234 0.1410348883696965 0.3227982362732291 0.1410348883696965 0.0881527480004089 0.04966599789876785 0.3333333333333333 1 0.0857388911147912 0.0857388911147912 0.1410348883696965 0.1410348883696965 False False 0.11298574694979283 2.723601629963301 1.8216565241617504 0.6521072723455675 62 62.0 113 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +phentermine phentermine BRD-K96319534 3 2 HEPG2;PHH -0.0237944473822911 -0.12034027775128679 0.2455285659858158 0.028725910000503 0.028725910000503 0.123619834715057 -0.022025983226263812 0.3333333333333333 1 -0.0237944473822911 -0.0237944473822911 0.028725910000503 0.028725910000503 False False 0.11260684310192509 2.7229471107941503 0.9675517475961702 -0.22211950911782263 63 202.0 359 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +epicatechin-gallate-(-) epicatechin-gallate-(-) BRD-K50660797 3 2 HEPG2;PHH 0.0380055519441763 -0.17612778830031556 -0.0244285826172147 0.2895750068128109 -0.0244285826172147 0.1661754737475089 -0.13098731845439898 0.3333333333333333 1 0.0380055519441763 0.0380055519441763 -0.0244285826172147 -0.0244285826172147 False False 0.10068181452030942 2.7023477955766917 0.804323004375796 0.003440995184032347 64 151.0 284 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +chlorphenamine chlorphenamine BRD-A04553218;BRD-K89595132 6 2 HEPG2;PHH 0.022950760864963102 -0.18358396128233934 0.19107768791062485 0.1389621100388467 0.057086220742868496 0.1016097704599064 -0.008013357308560176 0.3333333333333333 2 -0.2462944500148296 0.0413540168147948 0.008785713996206 0.105386727489531 True False 0.09760309180562632 2.6970296045775792 1.206886433830242 -0.11732187980559985 65 132.0 193 0 1 True True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nbqx NBQX BRD-K47717570 3 2 HEPG2;PHH -0.0090433197716871 -0.032613327933682254 0.0308714370642389 0.0208250079303979 0.0208250079303979 0.408827374031442 -0.6315727211675414 0.3333333333333333 1 -0.0090433197716871 -0.0090433197716871 0.0208250079303979 0.0208250079303979 False False 0.0930410134476713 2.6891490624472953 0.2819896847198623 0.1476976865427765 66 324.0 352 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mitotane mitotane BRD-A31204924 3 2 HEPG2;PHH -0.3768854752803842 -0.45590107096359134 0.1330142904605184 0.3544494025409221 0.1330142904605184 0.1460435579841335 -0.11678142127181806 0.3333333333333333 1 -0.3768854752803842 -0.3768854752803842 0.1330142904605184 0.1330142904605184 False False 0.08765284734822446 2.679841534908314 1.8717798341389367 -3.556950097333384 67 478.0 558 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +psb-06126 PSB-06126 BRD-K71266197 3 2 HEPG2;PHH -0.0164333403938346 -0.1504847258329391 0.2248428761959076 0.0871062465012073 0.0871062465012073 0.0743455823274358 0.022925179318657896 0.3333333333333333 1 -0.0164333403938346 -0.0164333403938346 0.0871062465012073 0.0871062465012073 False False 0.08580817198676474 2.6766550394643387 1.2296120911563788 -0.2687393818271552 68 181.0 288 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ketorolac ketorolac BRD-A40639672 3 2 HEPG2;PHH 0.0166166607911388 -0.09442777833383945 0.1222457726086889 0.0447801481932401 -0.0117857094321932 0.0699764987276423 0.02383607644439925 0.3333333333333333 1 0.0166166607911388 0.0166166607911388 -0.0117857094321932 -0.0117857094321932 False False 0.08189453694984193 2.669894619460319 0.5433352077633024 0.12048493133522198 69 219.0 299 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +etomidate etomidate BRD-A54880345 3 2 HEPG2;PHH 0.189117331109527 0.08991838683788145 0.2381105449582849 0.1923187635838985 0.1923187635838985 0.3121716815623499 -0.4698865864544161 0.3333333333333333 1 0.189117331109527 0.189117331109527 0.1923187635838985 0.1923187635838985 False False 0.07722838833514187 2.661834306186613 1.8530080550657204 1.8135227538224685 70 46.0 49 5 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +vardenafil vardenafil BRD-K13926615 3 2 HEPG2;PHH 0.0583555524547894 -0.030367114891608545 0.0321928582021168 0.0919474642723798 -0.1061562448740005 0.1787832309270189 -0.2049482877011455 0.3333333333333333 1 0.0583555524547894 0.0583555524547894 -0.1061562448740005 -0.1061562448740005 False False 0.07630908707644614 2.6602463035853554 0.17367261810669943 0.5909793651480333 71 208.0 225 0 1 True 23581791 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +acarbose acarbose BRD-A16444946;BRD-K44276885 4 2 HEPG2;PHH 0.061346439437733755 -0.2485645696934726 -0.0634572207927704 0.14882523752748958 -0.0634572207927704 -0.06369813224152909 -0.8175086941318734 0.5 2 0.061346439437733755 0.0930002334838112 -0.07112999792609896 0.015522740382168998 False True -0.4724524793074658 2.656516419773808 0.16700981734042006 -0.0720004847717271 72 213.0 304 0 1 True 41774;444254 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +losartan losartan BRD-K76205745 3 2 HEPG2;PHH 0.1422083328167597 -0.0529914674245649 0.1934285759925842 -0.0046187471598386 -0.0046187471598386 0.2296851264933745 -0.3463152730467892 0.3333333333333333 1 0.1422083328167597 0.1422083328167597 -0.0046187471598386 -0.0046187471598386 False False 0.05652748996997989 2.6260755381643754 0.6267963764727986 1.0629890763782037 73 103.0 223 0 1 True 3961;73707547 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +yohimbine yohimbine BRD-A51410489;BRD-A87445400 4 2 HEPG2;PHH -0.09668749777807129 -0.27205730022655594 0.41556009011609213 0.309143727645278 0.2855062490063054 0.2283138586171267 0.19198131632237206 0.25 2 -0.2673694458272722 0.0739944502711296 0.2839624807238579 0.2870500172887529 True False 0.32430451677831273 2.6165331397493663 2.971181904432619 -1.1683834384702905 74 83.0 277 1 1 True 2866;7059505 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +niguldipine niguldipine BRD-A43331270;BRD-A62336480 3 2 HEPG2;PHH 0.1247684756914774 -0.10993349906574525 0.2394519448280334 0.1012627510353922 0.1012627510353922 0.2517397842843026 -0.41046856448335184 0.3333333333333333 2 0.1247684756914774 0.13290080363448292 -0.09967239759862423 0.1012627510353922 False True 0.046505502042626684 2.6087635386997046 1.3518285310947338 0.7720378333437937 75 80.0 135 0 1 True 1236;71317558 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +f-1061-0166 F-1061-0166 BRD-A75931230 3 2 HEPG2;PHH 0.188827596604824 -0.1290748551901844 0.0551925557000296 0.0870199128985405 0.0551925557000296 0.0975877035941396 -0.11237269042739795 0.3333333333333333 1 0.188827596604824 0.188827596604824 0.0551925557000296 0.0551925557000296 False False 0.04140135838044062 2.5999466320153335 0.6405233019644404 1.126819638365938 76 96.0 137 0 0 True 3646984 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +emf-sumo1-10 EMF-sumo1-10 BRD-A80788753 3 2 HEPG2;PHH -0.0825536770539151 -0.17197208758443588 0.2301168856876237 0.2208962012082338 0.1770792342722416 0.0284526029542561 0.02273223143337025 0.3333333333333333 1 -0.0825536770539151 -0.0825536770539151 0.1770792342722416 0.1770792342722416 False False 0.03981871867094123 2.5972127774146068 1.8755526661235435 -0.7639156166773059 77 176.0 331 0 0 True 24761501 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ro-04-6790 Ro-04-6790 BRD-K43290182 3 2 HEPG2;PHH 0.4211833419071303 0.39128056127164096 -0.2883500116212027 0.1345937363803386 -0.2883500116212027 0.0827770875027729 -0.08817413543897959 0.3333333333333333 1 0.4211833419071303 0.4211833419071303 -0.2883500116212027 -0.2883500116212027 False False 0.03869001978328311 2.5952630609830414 -1.123268103801151 4.258041552845558 78 51.0 188 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +prednisone prednisone BRD-A62525898 3 2 HEPG2;PHH 0.4679000046518113 0.36816012290202904 0.0216071467314447 -0.106774996034801 -0.106774996034801 0.2651535859479317 -0.4677128060942606 0.3333333333333333 1 0.4679000046518113 0.4679000046518113 -0.106774996034801 -0.106774996034801 False False 0.03129718290080141 2.5824926616291757 -0.45364647067473746 4.488126371972259 79 31.0 112 3 1 True 40469477 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +stk-249718 STK-249718 BRD-K81142122 11 3 HEPG2;HUH7;PHH -0.0874331403109762 -0.2110995149446858 0.6387470343283245 0.3268000055104494 0.3056777156889438 0.4484110074856924 0.1592476463374046 0.18181818181818182 1 -0.0874331403109762 -0.0874331403109762 0.3056777156889438 0.3056777156889438 False False 0.5280348306543947 2.582192865205811 3.74280352389874 -0.9178571333294507 80 36.0 197 3 0 True 906542 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +amoxapine amoxapine BRD-K02265150 3 2 HEPG2;PHH 0.4839423899021413 0.1838754220969147 0.0060764742749077 0.1598120564594864 -0.2796495908073017 0.1776146902850576 -0.3179664307769152 0.3333333333333333 1 0.4839423899021413 0.4839423899021413 -0.2796495908073017 -0.2796495908073017 False False 0.018631474896599998 2.560613895482396 -0.14541523598087663 4.01567660471768 81 8.0 44 5 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tyrphostin-a9 tyrphostin-A9 BRD-K40255344 14 3 HEPG2;HUH7;PHH 0.03863028643859755 -0.20312871018217665 0.2712329019393239 0.16543418448418376 0.0418050826992839 0.18542972612305586 -0.04283207156399764 0.2857142857142857 1 0.03863028643859755 0.03863028643859755 0.0418050826992839 0.0418050826992839 False False 0.16401369034105703 2.541975444227168 1.4865554360121775 -0.0769515465355694 82 91.0 156 0 1 True 5614 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k86574132 BRD-K86574132 BRD-K86574132 13 3 HEPG2;HUH7;PHH 0.0528600513935089 -0.086718665021989 0.3116611753191267 0.026625758036971 0.026625758036971 0.1685186446393056 -0.158075930757655 0.3076923076923077 1 0.0528600513935089 0.0528600513935089 0.026625758036971 0.026625758036971 False False 0.0894806792604781 2.5377371187603726 1.1536061905544965 0.3791877248759756 83 115.0 283 0 0 True 7326481 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +anandamide anandamide BRD-K78280988;BRD-K87905482 3 2 HEPG2;PHH 0.0186972104840808 -0.0623624992246429 0.2497928653444562 -0.1124564250931143 -0.1124564250931143 0.0830396606867748 -0.17027341790260775 0.3333333333333333 2 0.0186972104840808 0.09335399243152806 -0.17879696330055592 0.2497928653444562 False True -0.0020970482645290695 2.524807408339315 0.1970034999165231 0.23422522996068207 84 244.0 460 0 1 True 5281969 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dup-697 DUP-697 BRD-K06221026 3 2 HEPG2;PHH -0.1778057279686133 -0.19612324010166854 0.1109714436211756 0.1682166727259755 0.1109714436211756 0.0092629635085662 -0.032791865276291 0.3333333333333333 1 -0.1778057279686133 -0.1778057279686133 0.1109714436211756 0.1109714436211756 False False -0.0071329691295793 2.516108349833973 1.192732551335019 -1.4559848494562457 85 380.0 475 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +vecuronium vecuronium BRD-K20168442;BRD-K61341215 3 2 HEPG2;PHH 0.0359042808413505 0.008864060044288649 0.1094444394111633 0.0030776187777519 0.0030776187777519 0.0921653099358081 -0.21837432868778708 0.3333333333333333 2 0.0359042808413505 0.1479713693261147 -0.1560038570314646 0.0030776187777519 False True -0.017021854408085443 2.499026272117591 0.41842247674247934 0.5683397549285635 86 234.0 326 0 1 True 28280238;39764;57369718 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mdl-29951 MDL-29951 BRD-K59753853 3 2 HEPG2;PHH -0.0849031429323885 -0.21842379805942375 0.4516857266426086 -0.0786687582731247 -0.0786687582731247 0.0389714133408334 -0.12223384653528532 0.3333333333333333 1 -0.0849031429323885 -0.0849031429323885 -0.0786687582731247 -0.0786687582731247 False False -0.022145509926809262 2.490175660618129 0.9880291055261068 -0.9243852747724035 87 215.0 498 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +diclofenac diclofenac BRD-K08252256 3 2 HEPG2;PHH 0.041723178492652 -0.11491942509180969 0.1073508337140083 0.1205092323943972 0.0668724961578846 0.0536795780062675 -0.16200937658903145 0.3333333333333333 1 0.041723178492652 0.041723178492652 0.0668724961578846 0.0668724961578846 False False -0.027325110288248224 2.4812284098995656 0.9264545723795481 0.21891291238735455 88 174.0 191 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k55149044 BRD-K55149044 BRD-K55149044 12 3 HEPG2;HUH7;PHH 0.0266963589108652 -0.10547555610537528 0.07975884846278594 0.06125695724040265 0.014380385833127101 0.09806397433082259 -0.2726092328140069 0.3333333333333333 1 0.0266963589108652 0.0266963589108652 0.014380385833127101 0.014380385833127101 False False -0.03824064207618086 2.4623729012081683 0.5325247770140706 0.1511802892916524 89 225.0 270 0 0 True 54654201 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a57107094 BRD-A57107094 BRD-A57107094 3 2 HEPG2;PHH -0.0616831580797831 -0.07776750417219265 0.0153008944221905 0.2154663894325494 0.0153008944221905 0.0514969129617961 -0.18130376332232526 0.3333333333333333 1 -0.0616831580797831 -0.0616831580797831 0.0153008944221905 0.0153008944221905 False False -0.03915496869936653 2.4607934918009864 0.8031959518534726 -0.33423238673972744 90 283.0 355 0 0 True 2864482 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +f-1566-0341 F-1566-0341 BRD-K69852452 3 2 HEPG2;PHH 0.0901090842154291 0.0519222817901108 -0.076499866587775 0.3667569290846586 -0.076499866587775 0.1204878155822082 -0.3357080670354504 0.3333333333333333 1 0.0901090842154291 0.0901090842154291 -0.076499866587775 -0.076499866587775 False False -0.04736621793551701 2.4466093655167658 0.7461640090792185 1.0538450943066282 91 113.0 283 1 0 True 5056826 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +donepezil donepezil BRD-A49160188 3 2 HEPG2;PHH -0.0541444561547703 -0.1072079844565855 0.0532142860548836 0.0463518602773547 0.0463518602773547 0.0368958591069612 -0.2013877059724773 0.3333333333333333 1 -0.0541444561547703 -0.0541444561547703 0.0463518602773547 0.0463518602773547 False False -0.06379799387927745 2.418225087027907 0.49041065628378344 -0.37750130567466544 92 348.0 381 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nsc-95397 NSC-95397 BRD-K68143200 12 3 HEPG2;HUH7;PHH -0.3408960566545526 -0.4897496360944286 0.27973429858684534 0.4042212422937155 0.27907285759491574 0.2644436817379698 -0.11016286619650635 0.25 1 -0.3408960566545526 -0.3408960566545526 0.27907285759491574 0.27907285759491574 False False 0.2093622486397166 2.4179816648416375 2.8329028196230777 -3.4298488720651568 93 341.0 535 0 1 True 262093 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k67808578 BRD-K67808578 BRD-K67808578 3 2 HEPG2;PHH 0.0772457176612483 0.047548207557863646 0.1494616945939404 -0.0341317877173423 -0.0341317877173423 0.0027655499381205 -0.14405130065741045 0.3333333333333333 1 0.0772457176612483 0.0772457176612483 -0.0341317877173423 -0.0341317877173423 False False -0.06926010039058472 2.408789834692226 0.33161355975306717 0.9569050339045364 94 187.0 321 0 0 True 768699 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rofecoxib rofecoxib BRD-K21733600 3 2 HEPG2;PHH 0.0101277733014689 -0.01749274051851695 -0.0177124898348535 0.3625435139983892 -0.0177124898348535 0.1007335229909845 -0.3631926685763849 0.3333333333333333 1 0.0101277733014689 0.0101277733014689 -0.0177124898348535 -0.0177124898348535 False False -0.08086281129720795 2.3887472915899775 1.0597272491124086 0.3190723169317399 95 137.0 310 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +l-689560 L-689560 BRD-A28422058;BRD-K74284736 3 2 HEPG2;PHH 0.1122090506056944 -0.004252975806593909 0.1020781014646802 0.0496514765545725 -0.0295730307698249 -0.0619949929874449 -0.08686486183340465 0.3333333333333333 2 -0.1207150022188822 0.16062034894194865 -0.0726216730129506 -0.0295730307698249 True False -0.10542742390414722 2.3463143368325183 0.4520959016094278 1.021223865313896 96 131.0 194 0 1 True 4267713;6604749 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gw-441756 GW-441756 BRD-K04146668;BRD-K28178212 3 2 HEPG2;PHH -0.091814962733123 -0.3395650896968113 0.2192652715103966 0.1293075203429907 0.1293075203429907 -0.0319558066567258 -0.1658827420915403 0.3333333333333333 2 -0.3395650896968113 0.158680013484425 0.10872217547148465 0.1293075203429907 True False -0.11489717770249595 2.3299562675676238 1.447075334776136 -1.3479525523843123 97 248.0 366 0 1 True 22228376;9943465 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +selamectin selamectin BRD-A58564983 3 2 HEPG2;PHH 0.2182166584146519 0.1654057076149102 -0.0581500040633337 -0.0658499971032142 -0.2113562393933534 -0.0365874822591505 -0.17304790337451748 0.3333333333333333 1 0.2182166584146519 0.2182166584146519 -0.2113562393933534 -0.2113562393933534 False False -0.12311143394640923 2.315766946972937 -0.837315979020576 2.237937222557804 98 164.0 285 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +chlorpromazine chlorpromazine BRD-K89997465 4 2 HEPG2;PHH -0.031446277681324256 -0.2727690256304211 0.1434324362448284 0.23111665993928904 0.016663862658398504 0.22794996302885306 -0.1575964607800993 0.25 1 -0.031446277681324256 -0.031446277681324256 0.016663862658398504 0.016663862658398504 False False 0.1491517326388034 2.313973914250518 1.2365252490332013 -0.748317703900366 99 166.0 267 0 1 True 15491403;160588;165214;70413 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +aminoglutethimide aminoglutethimide BRD-A25234499 4 2 HEPG2;PHH 0.11883388025065256 0.03372639169295623 0.06455921701022556 0.1679568737745285 -0.09778706543147565 0.15475819922525375 -0.05096712110504978 0.25 1 0.11883388025065256 0.11883388025065256 -0.09778706543147565 -0.09778706543147565 False False 0.12927463867272887 2.2796381873873166 0.519079918227091 1.1828725660813166 100 111.0 146 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +lovastatin lovastatin BRD-A70155556;BRD-K09416995 4 2 HEPG2;PHH 0.008404212693373346 -0.1066932882596221 0.398381592971938 -0.09800497069954864 -0.09800497069954864 0.15585533352125253 -0.060685859941360054 0.25 2 -0.0722854948706097 0.0890939202573564 -0.1148810870945453 -0.081128854304552 True False 0.1255124035505725 2.2731392958607195 0.7213944284868496 0.02897138496143191 101 160.0 455 0 1 True 3565209;53232;7048568 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +resorcinol resorcinol BRD-K85603128 3 2 HEPG2;PHH 0.2053333272536595 0.06698197548070714 -0.0856500055108751 0.0517062507569789 -0.0963687552139163 0.1014569237059543 -0.5075037153252948 0.3333333333333333 1 0.2053333272536595 0.2053333272536595 -0.0963687552139163 -0.0963687552139163 False False -0.1522949339566931 2.265355318040883 -0.2738846309664677 1.8467592538120416 102 130.0 222 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +erythromycin-ethylsuccinate erythromycin-ethylsuccinate BRD-K51677086 3 2 HEPG2;PHH 0.0154139010442627 -0.002010880038142199 0.1569097765854426 0.2610513232648372 -0.0276862420141696 0.0384963053086447 -0.43043247783290495 0.3333333333333333 1 0.0154139010442627 0.0154139010442627 -0.0276862420141696 -0.0276862420141696 False False -0.17671993360780777 2.223163530947366 1.2528342148074376 0.4017025194113042 103 113.0 178 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nu-1025 NU-1025 BRD-K48692744 3 2 HEPG2;PHH 0.0414234018988079 -0.14026172283209032 0.1775146153356347 0.170402854681015 0.170402854681015 0.0742884648387276 -0.5074268793724181 0.3333333333333333 1 0.0414234018988079 0.0414234018988079 0.170402854681015 0.170402854681015 False False -0.1794249748474815 2.2184908379813995 1.550261767971945 0.13772301228124342 104 120.0 157 0 1 True 63306 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pizotifen pizotifen BRD-K75958195 3 2 HEPG2;PHH 0.0167027790513303 -0.0958765467318396 0.0898785750780786 -0.0553250107914209 -0.0553250107914209 -0.0694758169471271 -0.2200618020613633 0.3333333333333333 1 0.0167027790513303 0.0167027790513303 -0.0553250107914209 -0.0553250107914209 False False -0.17950671797780876 2.2183496347551808 0.03590466073611885 0.11651181899787395 105 306.0 412 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ranitidine ranitidine BRD-K14204120;BRD-K30816563;BRD-K70505054 7 2 HEPG2;PHH 0.1589276064187288 -0.03669304897387825 -0.0011714398860931 -0.0042624957859516 -0.0042624957859516 0.0710325974320608 -0.19416627457868008 0.2857142857142857 3 -0.036693048973878255 0.2266532749765449 -0.1648139674216509 0.20427901936428886 True True -0.02605053985727923 2.213658160740311 0.04700761279350765 1.2221769136209404 106 166.0 234 0 1 True 3033332;6603542 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ipratropium ipratropium BRD-A05352148;BRD-A07029265 4 2 HEPG2;PHH -0.04700364420811336 -0.10536534816492348 0.22581508968557623 0.0691254609264433 0.0691254609264433 0.06947955172435036 0.02541128390039945 0.25 2 -0.0752239359749688 0.0134444518221749 0.0623634178191423 0.0758875040337443 True False 0.08218519367455009 2.198295797782641 1.1327590073444032 -0.32551824642676425 107 218.0 343 0 1 True 5702074 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +calmidazolium calmidazolium BRD-A26199074;BRD-A98283014 4 2 HEPG2;PHH -0.0657458211709228 -0.3425738532354848 0.7177800408431462 0.2066021033097058 0.06417789682745936 0.1766305441362044 -0.20530332107603225 0.25 2 -0.49411405638481176 0.09874972990817485 0.034862544387578936 0.06417789682745936 True False 0.07397888359818829 2.1841202034116733 3.001843559478051 -1.1886218895612242 108 35.0 217 3 1 True 2531;644274 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cilostazol cilostazol BRD-K67017579 3 2 HEPG2;PHH -0.3803277694516712 -0.40140138525101876 0.0974049695900508 0.2518187537789345 0.0809855386614799 0.010232598712993 -0.43942146281164796 0.3333333333333333 1 -0.3803277694516712 -0.3803277694516712 0.0809855386614799 0.0809855386614799 False False -0.20947813269283097 2.1665769605848455 1.3253858482328806 -3.408801833791669 109 515.0 563 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +l-694247 L-694247 BRD-K18816859 3 2 HEPG2;PHH 0.0025626487202114 -0.0013732941200336 0.0136625937053135 0.313784446567297 0.0136625937053135 0.1584142831760266 -0.7791131533061466 0.3333333333333333 1 0.0025626487202114 0.0025626487202114 0.0136625937053135 0.0136625937053135 False False -0.2311422934770467 2.129154251376101 1.088032609946053 0.32051315364580085 110 152.0 281 0 1 True 132059 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ambroxol ambroxol BRD-K56558538 3 2 HEPG2;PHH 0.2222777725093894 0.214442616328597 -0.0382571262972695 0.0598500110208988 -0.1124999905005097 0.062538120629532 -0.5921724128522098 0.3333333333333333 1 0.2222777725093894 0.2222777725093894 -0.1124999905005097 -0.1124999905005097 False False -0.23354808579657288 2.1249984815179004 -0.1491284051159114 2.4175703242393984 111 107.0 181 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +flunarizine flunarizine BRD-K12184470;BRD-K29582677 4 2 HEPG2;PHH 0.016875274686349702 -0.037743605052431475 0.009805959516337948 0.2599247766193002 0.009805959516337948 0.12731326343528626 -0.180971442281993 0.25 2 -0.06233581445283365 0.016875274686349702 -0.22953023635117076 0.1236244482653482 True True 0.036827542294289764 2.1199449115008244 0.9056196927134785 0.2994195721880898 112 171.0 266 0 1 True 941361 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +enzastaurin enzastaurin BRD-K79404599 4 2 HEPG2;PHH 0.004051306284964051 -0.009871172822184025 0.23823925746338703 0.02584421588107945 0.02584421588107945 0.13421869240257706 -0.2285340828821063 0.25 1 0.004051306284964051 0.004051306284964051 0.02584421588107945 0.02584421588107945 False False 0.019951650961523903 2.0907934673126607 0.9297720546140871 0.30357463343573693 113 186.0 337 0 1 True 176167 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fluspirilene fluspirilene BRD-K77947974 4 2 HEPG2;PHH 0.18745578928954068 0.0386627407537566 0.29460991865822245 0.15539875114336604 -0.009577518794685595 0.07601588686543795 -0.1202729018201815 0.25 1 0.18745578928954068 0.18745578928954068 -0.009577518794685595 -0.009577518794685595 False False 0.0158794359553472 2.0837591159925455 1.39497438107134 1.642483176627667 114 45.0 57 4 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pd-98059 PD-98059 BRD-K62810658 15 3 HEPG2;HUH7;PHH 0.1907580314307577 -0.02452077840765315 -0.0880605493273053 0.0270988903939723 -0.0880605493273053 0.1363905665154258 -0.40278988863740645 0.26666666666666666 1 0.1907580314307577 0.1907580314307577 -0.0880605493273053 -0.0880605493273053 False False -0.06500437780327742 2.0384604552391496 -0.3333986631200688 1.4662726192203226 115 159.0 257 0 1 True 4713 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +anagrelide anagrelide BRD-K62200014 3 2 HEPG2;PHH 0.0340583320293161 -0.121312752366066 0.0353430738406521 0.0766737051308155 0.0353430738406521 -0.2005577591794823 -0.2106166032275983 0.3333333333333333 1 0.0340583320293161 0.0340583320293161 0.0353430738406521 0.0353430738406521 False False -0.30586606079328144 2.0000762850929696 0.4994655494947473 0.14930714227319772 116 242.0 249 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ar-a014418 AR-A014418 BRD-K67860401 14 3 HEPG2;HUH7;PHH 0.1686130728986528 -0.15294141032629538 0.08455646942768774 0.1807256182655692 0.0030922317611320003 0.0622350212541365 -0.44644210180674226 0.2857142857142857 1 0.1686130728986528 0.1686130728986528 0.0030922317611320003 0.0030922317611320003 False False -0.16098602964923464 1.9805703597993685 0.875142678518299 0.9213410480885031 117 70.0 106 0 1 True 448014 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cucurbitacin-i cucurbitacin-i BRD-A28105619;BRD-A49680073 14 3 HEPG2;HUH7;PHH 0.0185860548582342 -0.073183718835935 0.1335819150720324 0.3770616529509425 -0.0246353543230465 0.24933702965813964 0.080314756958701 0.14285714285714285 2 -0.059761981997225 0.0386317695180575 -0.0251212609665734 -0.0241494476795196 True False 0.28949440813749017 1.9494152224464267 1.5377184503485741 0.19966601932233585 118 80.0 172 1 1 True 73707401 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ellipticine ellipticine BRD-K85985071 14 3 HEPG2;HUH7;PHH -0.1785890776146617 -0.32896812694768107 0.4532054593520505 0.24039319250732655 0.2007471142070634 0.2144377691789515 -0.3243829674227902 0.21428571428571427 1 -0.1785890776146617 -0.1785890776146617 0.2007471142070634 0.2007471142070634 False False 0.052246285467556386 1.9442503171488021 2.6613289360463748 -1.8764830077286048 119 147.0 409 0 1 True 3213 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +biperiden biperiden BRD-A00546892;BRD-A36471396 5 2 HEPG2;PHH -0.0481111043029361 -0.1511277759240733 0.526809790304729 0.0560624748468399 0.0030812639743089 0.230525963111884 -0.2679344184312319 0.2 2 -0.09967082925140855 0.0228144394026862 -0.2098571423973356 0.25675000157207245 True True 0.09655875389626806 1.9398641692681615 1.824564392188834 -0.4757931867337513 120 100.0 356 1 1 True True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ran-07 RAN-07 BRD-K98381590 3 2 HEPG2;PHH -0.39966388957368 -0.44113502837717533 0.10209635751588 0.0948694422841072 0.0948694422841072 -0.1622152339726214 -0.3999949841360961 0.3333333333333333 1 -0.39966388957368 -0.39966388957368 0.0948694422841072 0.0948694422841072 False False -0.36221272604066945 1.9027429570477032 0.9057271287449941 -3.6582137022177843 121 545.0 568 0 0 True 1993104 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +naproxen naproxen BRD-A87719232;BRD-K59197931 3 2 HEPG2;PHH -0.0389486978658371 -0.1783738552799655 0.0645666952644075 0.0627458319067955 0.0090586170554161 -0.0021360417059253 -0.7266819994371857 0.3333333333333333 2 -0.0389486978658371 0.059086620807647705 -0.2754023665828364 0.0090586170554161 True True -0.36547704142451815 1.8971041729474485 0.4779420731363337 -0.5016899886448214 122 315.0 344 0 1 True 1302;23675324;23681059 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k51674646 BRD-K51674646 BRD-K51674646 12 3 HEPG2;HUH7;PHH 0.11587668913933966 -0.03716475826998543 0.14865426612751825 0.0572249570395797 -0.047177472284862 0.019481051546920654 -0.2473312417666117 0.25 1 0.11587668913933966 0.11587668913933966 -0.047177472284862 -0.047177472284862 False False -0.1041845693363852 1.8763603433734237 0.5689363365581936 0.9420431127570309 123 117.0 184 0 0 True 24002878 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +y-27152 Y-27152 BRD-K42679050 3 2 HEPG2;PHH 0.3709777891635895 0.03740496105617952 0.0940357191222054 0.0098062492907047 0.0098062492907047 -0.1587660091056947 -0.43795839440639295 0.3333333333333333 1 0.3709777891635895 0.3709777891635895 0.0098062492907047 0.0098062492907047 False False -0.3777452063088912 1.8759121234807863 0.4096886816123675 2.8264456006330545 124 36.0 74 4 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +quinidine quinidine BRD-K59632282;BRD-K70799801 3 2 HEPG2;PHH 0.4156777833898862 0.3520097247221403 0.1581743572439466 -0.2189562432467937 -0.2189562432467937 -0.0532065330457592 -0.6495027741387723 0.3333333333333333 2 0.3520097247221403 0.5336797212560972 -0.4829066941248519 0.1581743572439466 False True -0.3779579201151454 1.8755446812800278 -0.6677678382779846 4.099599001515531 125 39.0 163 3 1 True 10448938;11068;441074 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fpl-64176 FPL-64176 BRD-K78959463 3 2 HEPG2;PHH 0.1126270724667443 -0.05900152358743879 -0.0616881240691457 0.0216000005602836 -0.1027513779699802 -0.123719745507789 -0.508714365691597 0.3333333333333333 1 0.1126270724667443 0.1126270724667443 -0.1027513779699802 -0.1027513779699802 False False -0.3780769283535875 1.8753391062409104 -0.30858391807844937 0.852721950051689 126 233.0 294 0 1 True 3423 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sertraline sertraline BRD-K82036761 3 2 HEPG2;PHH 0.0782833447058995 -0.296919443541103 -0.179342398153884 0.2349687702953815 -0.179342398153884 -0.0255913531466845 -0.7247795647357606 0.3333333333333333 1 0.0782833447058995 0.0782833447058995 -0.179342398153884 -0.179342398153884 False False -0.38798113551456476 1.8582305614779642 -0.21840519762627056 -0.11358540057428029 127 211.0 396 0 1 True 6093397 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +escitalopram escitalopram BRD-K70301876 3 2 HEPG2;PHH 0.2199611133999294 0.029990481419695736 -0.0557455154401915 0.2792673502117395 -0.0557455154401915 -0.1318375063350512 -0.5198274802874834 0.3333333333333333 1 0.2199611133999294 0.2199611133999294 -0.0557455154401915 -0.0557455154401915 False False -0.3917512464787929 1.8517180652080047 0.5997577065807642 1.825763090364576 128 55.0 161 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mestranol mestranol BRD-A14798026;BRD-K31920458 4 2 HEPG2;PHH 0.2844753735181358 0.18861248220006618 -0.1318427066185644 0.17494759708642954 -0.1318427066185644 -0.03241864396702675 -0.17385903301294003 0.25 2 0.12740554577774466 0.3531295526772737 -0.35889292189053124 0.06959080509841445 False True -0.11934816047349676 1.850166729536424 -0.13430713385997553 2.739386034759698 129 67.0 171 2 1 True 12598376;6291;7076513 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nifedipine nifedipine BRD-K96354014 3 2 HEPG2;PHH 0.1517639503710799 -0.06705791027181682 -0.0654917444501604 0.0736135002225637 -0.0654917444501604 -0.2452728061803749 -0.3126646579420638 0.3333333333333333 1 0.1517639503710799 0.1517639503710799 -0.0654917444501604 -0.0654917444501604 False False -0.4016051351514068 1.834696440689817 -0.06912675431714868 1.0808523213042316 130 167.0 230 0 1 True 4485 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k80045183 BRD-K80045183 BRD-K80045183 12 3 HEPG2;HUH7;PHH -0.11138952585558096 -0.2821749941859808 0.3061893747321196 0.41681995894759893 0.18933772428759504 0.13716372880818584 0.006066090782128573 0.16666666666666666 1 -0.11138952585558096 -0.11138952585558096 0.18933772428759504 0.18933772428759504 False False 0.1401967741992501 1.826404200776274 2.720061666158326 -1.2951859716151257 131 96.0 303 0 0 True 54654296 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +amsacrine amsacrine BRD-K98490050 3 2 HEPG2;PHH -0.1029638983309269 -0.1130041669950717 0.2129999973944255 -0.139624997973442 -0.139624997973442 -0.1911730150884342 -0.43539434574573993 0.3333333333333333 1 -0.1029638983309269 -0.1029638983309269 -0.139624997973442 -0.139624997973442 False False -0.40887018796130414 1.8221467757663066 -0.06372490035291394 -0.7116239415870689 132 418.0 523 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +vorinostat vorinostat BRD-K81418486 30 3 HEPG2;HUH7;PHH -0.0021582591450876494 -0.17225439546422822 0.11753183124320844 0.2564468802884221 -0.0041988393557923 0.0445865483008443 -0.2705724855130981 0.23333333333333334 1 -0.0021582591450876494 -0.0021582591450876494 -0.0041988393557923 -0.0041988393557923 False False -0.09069969445570475 1.8052339592921758 1.181441245108965 -0.24441738522661255 133 135.0 223 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +thioperamide thioperamide BRD-A85424553;BRD-K63874012 4 2 HEPG2;PHH 0.11462003458291284 -0.028325854697161295 0.06933359163148055 0.12438530847430225 -0.09095936747533935 -0.0861232410746789 -0.16945976882966024 0.25 2 0.022848485141164707 0.11462003458291284 -0.09095936747533935 0.0183567740023136 False True -0.17085312548950904 1.7611969629343822 0.42056319961659294 0.9615497757119956 134 125.0 149 0 1 True 3035905;6713984 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ezetimibe ezetimibe BRD-A41519720 3 2 HEPG2;PHH -0.0482021930317084 -0.0625649835500452 0.7706999672310693 0.3016187567263841 0.2945428660937718 0.4723777618436586 0.34676539959267727 0.0 1 -0.0482021930317084 -0.0482021930317084 0.2945428660937718 0.2945428660937718 False False 0.6457604616399972 1.7555139929892387 4.033512798365034 -0.1994324281430613 135 12.0 129 3 1 True 150311 True True False translation_review metabolic translation anchor; dual-axis consistency review required False Tier_4_not_prioritized +brd-k08438429 BRD-K08438429 BRD-K08438429 3 2 HEPG2;PHH 0.2291484392351574 0.07659703120589254 0.8621418731553214 -0.061602659523487 -0.061602659523487 0.5227660044125977 0.23481488744876106 0.0 1 0.2291484392351574 0.2291484392351574 -0.061602659523487 -0.061602659523487 False False 0.6401734481369782 1.745862976097731 2.309790538106599 2.03097685158098 136 11.0 187 4 0 True 9893924 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +saracatinib saracatinib BRD-K19540840 3 2 HEPG2;PHH 0.2258413607875506 0.1242338307201862 -0.21663612978799 -0.0131153110414743 -0.21663612978799 -0.2104390554928354 -0.4901432757088471 0.3333333333333333 1 0.2258413607875506 0.2258413607875506 -0.21663612978799 -0.21663612978799 False False -0.4555106933472589 1.7415798852325568 -1.1669735518593898 2.15853896638821 137 206.0 344 0 1 True 10302451 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k71701252 BRD-K71701252 BRD-K71701252 12 3 HEPG2;HUH7;PHH -0.07763417313496271 -0.19334318644056717 0.042523017419236 0.2608034401200712 0.03486085789544235 0.11138266836485215 -0.05898451074839582 0.16666666666666666 1 -0.07763417313496271 -0.07763417313496271 0.03486085789544235 0.03486085789544235 False False 0.08189041299065425 1.7256856905019655 1.070160444517796 -0.7989037248753007 138 257.0 358 0 0 True 6626036 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +amcinonide amcinonide BRD-A36010170 3 2 HEPG2;PHH -0.0188425834445903 -0.08804628694067805 0.0101428500243595 0.1617187424562871 0.0101428500243595 -0.059862051111099 -0.8207826891817921 0.3333333333333333 1 -0.0188425834445903 -0.0188425834445903 0.0101428500243595 0.0101428500243595 False False -0.47025339570199504 1.716113315413968 0.6138975520122039 -0.08907863465637311 139 266.0 314 0 1 True 2133;40469418 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pik-75 PIK-75 BRD-K49371609;BRD-M16762496 3 2 HEPG2;PHH -0.6439034529030323 -0.7492872590406073 0.7192571374720761 1.1666482165455818 0.7192571374720761 0.5370622043098722 0.16902146587473532 0.0 2 -0.6439034529030323 -0.5896133100613952 0.6390722329462213 1.1666482165455818 False False 0.6215729372472398 1.7137324210721274 7.5524295894438005 -6.202762725440365 140 70.0 564 2 1 True 10275789;73707389 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nsc-663284 NSC-663284 BRD-K03109492 12 3 HEPG2;HUH7;PHH 0.023535651723957753 -0.3756217869619528 0.04309075432164325 0.2362116882577538 -0.02309860927718025 0.164993705202101 -0.19759817366739582 0.16666666666666666 1 0.023535651723957753 0.023535651723957753 -0.02309860927718025 -0.02309860927718025 False False 0.06619461836840308 1.698572747434416 0.8500458808947711 -0.7140697451909381 141 157.0 245 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k63350243 BRD-K63350243 BRD-K63350243 3 2 HEPG2;PHH -0.0111261517223384 -0.34226919534719646 0.0462811376367296 0.1407853718847036 -0.1599807813763618 -0.2769529889485548 -0.41341274105648085 0.3333333333333333 1 -0.0111261517223384 -0.0111261517223384 -0.1599807813763618 -0.1599807813763618 False False -0.4836593594767952 1.6929558301550498 0.22407903533881574 -0.8341286130733976 142 249.0 281 0 0 True 2989846 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +guanabenz guanabenz BRD-K67847053 3 2 HEPG2;PHH 0.1201925203204155 0.08982662773794595 -0.1185535117983818 -0.1858939677476883 -0.1858939677476883 -0.169842974593242 -0.6276845692080402 0.3333333333333333 1 0.1201925203204155 0.1201925203204155 -0.1858939677476883 -0.1858939677476883 False False -0.4836852591972621 1.6929110909326415 -1.3116244724620296 1.367101356062696 143 377.0 465 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k41878610 BRD-K41878610 BRD-K41878610 12 3 HEPG2;HUH7;PHH -0.0187509680787722 -0.18756924890395665 0.12386400359017505 0.30939517077058554 0.0563846534517194 -0.053078167462011855 -0.32604086680322997 0.25 1 -0.0187509680787722 -0.0187509680787722 0.0563846534517194 0.0563846534517194 False False -0.21609860086362684 1.6830398496816652 1.5136702768380605 -0.39971022961316605 144 125.0 231 0 0 True 54654300 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k35860134 BRD-K35860134 BRD-K35860134 18 3 HEPG2;HUH7;PHH -0.19528228303210599 -0.5899798002921872 0.12661340566618096 0.3350094039924443 0.01392391776399945 0.043078878717053445 -0.4121724154415822 0.2222222222222222 1 -0.19528228303210599 -0.19528228303210599 0.01392391776399945 0.01392391776399945 False False -0.16300732900373766 1.617382837961427 1.4898255794727082 -2.8007605344305357 146 302.0 468 0 0 True 54646517 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +trichostatin-a trichostatin-a BRD-A19037878;BRD-K68202742 39 3 HEPG2;HUH7;PHH -0.0237501710653305 -0.2139238673779699 0.1168928486960274 0.2599839083850384 0.0021279752254486 0.1370600650589617 -0.4945032378817569 0.20512820512820512 2 -0.0245505407866504 0.1848079359365834 -0.29032315313816065 0.0292870210749762 True True -0.11019155388191673 1.611775689439398 1.2062927170353202 -0.5144841289120129 147 154.0 255 0 1 True 444732 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +clonidine clonidine BRD-K98530306 4 2 HEPG2;PHH 0.05538778364037475 -0.06579138297173706 -0.0688368002218859 0.1141842538490891 -0.0688368002218859 -0.12973402387329516 -0.3105934268336684 0.25 1 0.05538778364037475 0.05538778364037475 -0.0688368002218859 -0.0688368002218859 False False -0.2850307372901294 1.563966356721532 0.033602523112007926 0.4609921925644165 148 253.0 318 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +chloroquine chloroquine BRD-A91699651 4 2 HEPG2;PHH 0.012708241326941348 -0.016843497481507548 0.34244182599442347 -0.1211847602389753 -0.1211847602389753 -0.058035473586873144 -0.4579686347472791 0.25 1 0.012708241326941348 0.012708241326941348 -0.1211847602389753 -0.1211847602389753 False False -0.2870197909605127 1.5605304619343419 0.4255557823715227 0.3378053824194779 149 195.0 471 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k67774729 BRD-K67774729 BRD-K67774729 18 3 HEPG2;HUH7;PHH -0.10083851311355825 -0.34669668123953873 0.21976450750870363 0.17600327916443345 0.0826904089855296 0.0818348342981485 -0.199117241767309 0.16666666666666666 1 -0.10083851311355825 -0.10083851311355825 0.0826904089855296 0.0826904089855296 False False -0.017723786585505996 1.5536119480232569 1.4688934091801302 -1.4286615738078434 150 226.0 371 0 0 True 54645916 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +niclosamide niclosamide BRD-K35960502 4 2 HEPG2;PHH -0.15997070322434104 -0.2994509980910354 0.4964871406555176 0.453717099619098 0.38342266290315563 0.3877447954737507 0.2614528851944857 0.0 1 -0.15997070322434104 -0.15997070322434104 0.38342266290315563 0.38342266290315563 False False 0.5184712380709935 1.5356343656878977 3.895851926973136 -1.6636656555881921 153 77.0 328 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pd-0325901 PD-0325901 BRD-A50454580;BRD-K49865102 5 2 HEPG2;PHH 0.3888269828425513 0.1429306140376461 -0.0332070567778178 0.0444643450900912 -0.0338409654796123 0.4608209769108465 0.1122153964677145 0.0 2 0.3888269828425513 0.47436028615468073 -0.11660106347075525 -0.0332070567778178 False False 0.5169286751447038 1.532969739792544 0.021227989336981556 3.271975325148467 154 37.0 104 3 1 True 10206158;9826528 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +celecoxib celecoxib BRD-K02637541 4 2 HEPG2;PHH -0.01658695646458195 -0.023989643177224476 0.1202642800552504 0.03153390937950459 -0.11443399265408515 -0.07223494403759051 -0.4691984119657833 0.25 1 -0.01658695646458195 -0.01658695646458195 -0.11443399265408515 -0.11443399265408515 False False -0.3068341500204822 1.5263031034576109 0.23517777647174135 0.12583713524068138 155 274.0 347 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +15-delta-prostaglandin-j2 15-delta-prostaglandin-j2 BRD-K05396879;BRD-K61033289 4 2 HEPG2;PHH 0.2651127862433592 0.12482696254220271 -0.09208082514149804 0.2590450295247137 -0.13700063606458043 -0.07912318586623145 -0.45735255210653 0.25 2 0.2432489130232069 0.3018185051365031 -0.231966672199113 0.0478050219161169 False True -0.3077994619194964 1.524635621995838 0.22277876588195528 2.414588693837588 156 49.0 156 3 1 True 12068863;5311211;6375741 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fludarabine fludarabine BRD-A31374339;BRD-K72238567 3 2 HEPG2;PHH 0.0217454102304246 -0.42243701861136496 -0.0083499891417367 0.2935124933719635 -0.0083499891417367 -0.3332080340663355 -0.5348856065584908 0.3333333333333333 2 -0.4224370186113649 0.1465750071737501 -0.09394886876855575 1.5978437587618828 True True -0.6006508373455809 1.4908645467772654 0.9053002616763846 -0.8720564626708828 157 155.0 285 0 1 True 57007282;657237;8975 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k66383562 BRD-K66383562 BRD-K66383562 12 3 HEPG2;HUH7;PHH -0.16522611258551476 -0.2269311827710933 0.00332596898078915 0.2575738755986094 -0.034965456596442596 -0.0004907145722961503 -0.12275440665331502 0.16666666666666666 1 -0.16522611258551476 -0.16522611258551476 -0.034965456596442596 -0.034965456596442596 False False -0.06186791789895366 1.4773572984261487 0.7646682726612789 -1.4709013734748424 158 383.0 469 0 0 True 54654477 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +badge BADGE BRD-A16694057 3 2 HEPG2;PHH 0.1307984296646383 0.04714025743305686 0.0924542727214949 -0.1035246346145868 -0.1035246346145868 0.1872565469423693 -1.5984616337624926 0.3333333333333333 1 0.1307984296646383 0.1307984296646383 -0.1035246346145868 -0.1035246346145868 False False -0.611974269938877 1.471304429521651 -0.2238124821322758 1.302263698225057 159 194.0 339 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +omeprazole omeprazole BRD-A55962179 3 2 HEPG2;PHH 0.0144583280715677 0.0015041619125339498 0.0099642766373498 -0.0631874958053231 -0.0631874958053231 -0.1328428575384711 -0.9620661193002312 0.3333333333333333 1 0.0144583280715677 0.0144583280715677 -0.0631874958053231 -0.0631874958053231 False False -0.6138759171885867 1.4680195207383235 -0.2466246536680053 0.40650942708911736 160 356.0 420 0 0 True 4594 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tyrphostin-ag-879 tyrphostin-AG-879 BRD-K59469039 14 3 HEPG2;HUH7;PHH -0.20096017327159638 -0.40310391783714294 -0.01308472082018855 0.4235724899917841 -0.08474226422341805 0.08093882377244645 -0.16244415679414353 0.14285714285714285 1 -0.20096017327159638 -0.20096017327159638 -0.08474226422341805 -0.08474226422341805 False False -0.00028325462462532036 1.4488527812445842 1.0845101811372881 -2.2531207247717093 161 336.0 478 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pimozide pimozide BRD-K01292756 3 2 HEPG2;PHH 0.0103826204107867 -0.01408741085065735 -0.2255236772554261 0.1776825617998838 -0.2255236772554261 -0.4034094489253466 -0.45110866933735827 0.3333333333333333 1 0.0103826204107867 0.0103826204107867 -0.2255236772554261 -0.2255236772554261 False False -0.6289637835940257 1.4419567139351859 -0.645884117418579 0.33137090720767476 162 357.0 480 0 1 True 16362 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cgk-733 CGK-733 BRD-A50737080 14 3 HEPG2;HUH7;PHH -0.024308027389148848 -0.09404435733126265 0.43070956745318 0.18914790777489535 -0.01487762427755765 0.14320552618878465 -0.2998089663636323 0.14285714285714285 1 -0.024308027389148848 -0.024308027389148848 -0.01487762427755765 -0.01487762427755765 False False -0.006698956993031496 1.437770285758415 1.889184116084112 -0.1432121449822283 163 74.0 190 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +olmesartan-medoxomil olmesartan-medoxomil BRD-K78485176 3 2 HEPG2;PHH 0.1406448956372009 0.11566828299934659 -0.305571436882019 -0.146537497639656 -0.305571436882019 -0.3906668815466145 -0.49219341688449414 0.3333333333333333 1 0.1406448956372009 0.1406448956372009 -0.305571436882019 -0.305571436882019 False False -0.6367635899888615 1.4284833147342755 -2.0592688041348337 1.5802959666637206 164 439.0 519 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k84389640 BRD-K84389640 BRD-K84389640 12 3 HEPG2;HUH7;PHH 0.0349684500963323 -0.045307422522455426 -0.0263209539864744 0.2798983543179929 -0.09019200876355164 0.04146764986956165 -0.27755457719710347 0.16666666666666666 1 0.0349684500963323 0.0349684500963323 -0.09019200876355164 -0.09019200876355164 False False -0.0973096387289901 1.4161352079103555 0.6014761592062993 0.392879240470999 165 159.0 292 0 0 True 1244300 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ikk-2-inhibitor-v IKK-2-inhibitor-V BRD-K74305673 15 3 HEPG2;HUH7;PHH -0.1349314128359159 -0.1713524915070997 0.2834726476243564 0.2958759786561131 0.1368416603654623 0.1150701702350661 -0.22168698168862316 0.13333333333333333 1 -0.1349314128359159 -0.1349314128359159 0.1368416603654623 0.1368416603654623 False False 0.004226679390754523 1.4026888602764074 2.156266493063029 -1.1010070785315005 166 175.0 382 0 1 True 5081913 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +meloxicam meloxicam BRD-A84174393 4 2 HEPG2;PHH 0.06406484482189015 -0.027838892510367773 0.09088284043329095 -0.07556578470394015 -0.1083970139069217 -0.1638378701727128 -0.44401750009920865 0.25 1 0.06406484482189015 0.06406484482189015 -0.1083970139069217 -0.1083970139069217 False False -0.38584662022231714 1.389816824313016 -0.15739249287766824 0.6358404672887585 167 262.0 383 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k03652504 BRD-K03652504 BRD-K03652504 12 3 HEPG2;HUH7;PHH -0.10934909682772634 -0.1823307886305782 -0.0165046154787497 0.30431874142959714 -0.0165046154787497 -0.005508470092160954 -0.2199962584020954 0.16666666666666666 1 -0.10934909682772634 -0.10934909682772634 -0.0165046154787497 -0.0165046154787497 False False -0.11550659929320867 1.3847017464224822 0.8923631678917611 -0.9697495622091049 168 305.0 413 0 0 True 54657691 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gw-405833 GW-405833 BRD-K10705233 3 2 HEPG2;PHH -0.010896247294214 -0.022850146103236352 -0.0596286665116037 0.1929681729525327 -0.140926219522953 -0.322563019595922 -0.6791373747253113 0.3333333333333333 1 -0.010896247294214 -0.010896247294214 -0.140926219522953 -0.140926219522953 False False -0.6621317069585777 1.3846623851359876 0.11221235086484095 0.16623518116544617 169 279.0 368 0 1 True 9911463 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +bromocriptine bromocriptine BRD-A69960130;BRD-A80151636 4 2 HEPG2;PHH 0.3878145326679159 0.24927903101262122 0.061173006360019946 -0.019797473214566652 -0.02199003366487365 0.4461275680593052 -0.03616367120827951 0.0 2 0.2454494701491462 0.5250735140353855 -0.0247014984488487 -0.0148934479802846 False False 0.4280457324551654 1.3794331892185863 0.14158931698460997 3.597990883692539 170 41.0 88 4 1 True 73707474 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k19876534 BRD-K19876534 BRD-K19876534 18 3 HEPG2;HUH7;PHH -0.03417123895552425 -0.2559025118437906 0.020786796563437952 0.1735944794490933 -0.03779920516535635 0.02638872835548625 -0.3155692195268495 0.16666666666666666 1 -0.03417123895552425 -0.03417123895552425 -0.03779920516535635 -0.03779920516535635 False False -0.1313958814079385 1.3572545727221987 0.5585577304133216 -0.7132114009574406 171 271.0 329 0 0 True 54646516 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a14014306 BRD-A14014306 BRD-A14014306 12 3 HEPG2;HUH7;PHH -0.010900585601727152 -0.2135131280455324 0.031874179707041844 0.2453457480296492 -0.05394728481769555 -0.0621220488027329 -0.16144700169504156 0.16666666666666666 1 -0.010900585601727152 -0.010900585601727152 -0.05394728481769555 -0.05394728481769555 False False -0.14284554965025367 1.3374763957858025 0.7648914226561264 -0.4300272676164573 172 193.0 276 0 0 True 3915969 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +strychnine strychnine BRD-A09094913 3 2 HEPG2;PHH 0.022405563129319 -0.019289434939209 0.1730007295097623 -0.0728000178933143 -0.2317585628479719 -0.4380011939487996 -0.5049621052226968 0.3333333333333333 1 0.022405563129319 0.022405563129319 -0.2317585628479719 -0.2317585628479719 False False -0.690482246560148 1.335689613470004 -0.21925900756800698 0.3929250697126104 173 260.0 423 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +thalidomide thalidomide BRD-A93255169 4 2 HEPG2;PHH -0.045765559706423 -0.2815909050405025 0.029595655522176204 0.002738638781011101 -0.0617532088820423 -0.23698198594271191 -0.3631925884900349 0.25 1 -0.045765559706423 -0.045765559706423 -0.0617532088820423 -0.0617532088820423 False False -0.41857828018772936 1.3332760976721032 0.012823020718251824 -0.8685905855533862 174 373.0 416 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +paclitaxel paclitaxel BRD-A23723433;BRD-A28746609 5 2 HEPG2;PHH 0.0107555546694331 -0.017428880971339 -0.0146828836628368 0.1496271383948624 -0.0146828836628368 0.0280189209004184 -0.5858665148557594 0.2 2 0.0107555546694331 0.1452291320763632 -0.2701714230435235 0.06811431688921796 False True -0.26491433652746127 1.3154549209962763 0.4400130176869733 0.3233355006396123 175 252.0 305 0 1 True 4666;73707502 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rosuvastatin rosuvastatin BRD-K82941592 3 2 HEPG2;PHH 0.2233904989229308 0.1307188620169957 0.216128582400935 -0.3048499980941415 -0.3048499980941415 -0.4635884798767548 -0.4837146627435845 0.3333333333333333 1 0.2233904989229308 0.2233904989229308 -0.3048499980941415 -0.3048499980941415 False False -0.705445811248547 1.309841525670167 -0.9710600101718535 2.1629548559447196 176 141.0 450 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +aminopentamide aminopentamide BRD-A69917777 3 2 HEPG2;PHH -0.0583138830131954 -0.1352916647576623 0.4207928606442043 0.3456125017255544 0.3456125017255544 0.2723263904659284 0.22162981257433922 0.0 1 -0.0583138830131954 -0.0583138830131954 0.3456125017255544 0.3456125017255544 False False 0.383141296753098 1.3018651884915244 3.2496369333869217 -0.4923113143786104 177 67.0 201 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k18710049 BRD-K18710049 BRD-K18710049 12 3 HEPG2;HUH7;PHH 0.0100376248980562 -0.10528950434592035 0.06110208854079251 0.1149208499118685 -0.0832509452344051 -0.028444119344746298 -0.2777626425330897 0.16666666666666666 1 0.0100376248980562 0.0100376248980562 -0.0832509452344051 -0.0832509452344051 False False -0.16732544061129115 1.2951897893475721 0.38738293162272225 0.04393394876891742 178 237.0 252 0 0 True 54618864 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +medrysone medrysone BRD-A20126139;BRD-K56515112 4 2 HEPG2;PHH -0.027152024726900797 -0.10749476392649937 0.14766001275607515 -0.08371691638603805 -0.1621623419092169 -0.25059339118796203 -0.4252491756194522 0.25 2 -0.05423699433190955 0.001627684260408102 -0.19012853503227237 -0.1621623419092169 True False -0.46321797899768813 1.256165403915244 -0.14958550154520478 -0.20368230990654412 179 335.0 474 0 1 True 247839;5702081;73707449 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fulvestrant fulvestrant BRD-A83237092;BRD-A90490067 9 2 HEPG2;PHH -0.1577356685366895 -0.2324752906958262 0.0382999990667615 0.129635146819055 0.0260206270031631 -0.0405124779273238 -0.6808948727945486 0.2222222222222222 2 -0.1975963217102819 -0.13631935355563954 -0.01927163288928565 0.0382999990667615 False True -0.38095991432459814 1.2408911610856135 0.6427837707179295 -1.4397547848560206 180 411.0 472 0 1 True 5284640;73707501 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +butyl-paraben butyl-paraben BRD-K08287586 3 2 HEPG2;PHH 0.203190165054467 -0.04231196031388304 -0.2029281577893666 0.0129307182505726 -0.2029281577893666 -0.4620859655773355 -0.5746455038565077 0.3333333333333333 1 0.203190165054467 0.203190165054467 -0.2029281577893666 -0.2029281577893666 False False -0.7494087175055894 1.2338999245522844 -1.013054328419669 1.4911070222437242 181 209.0 333 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k69096174 BRD-K69096174 BRD-K69096174 12 3 HEPG2;HUH7;PHH 0.038049668694535854 -0.07907993594805397 0.0136780953034759 -0.00523293181322515 -0.1573049829208425 -0.246909915064905 -0.48583656114836526 0.25 1 0.038049668694535854 0.038049668694535854 -0.1573049829208425 -0.1573049829208425 False False -0.48982819563908764 1.210198869172835 -0.30307108451097886 0.3072110798363698 182 295.0 334 0 0 True 54618368 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +strophanthidin strophanthidin BRD-K84595254 14 3 HEPG2;HUH7;PHH -0.25588815535108245 -0.4330876411663161 0.5303269691233123 0.3173599783331156 0.2587699228897691 0.27383692640190316 -0.361238288974005 0.07142857142857142 1 -0.25588815535108245 -0.25588815535108245 0.2587699228897691 0.2587699228897691 False False 0.09321778191490065 1.2057087186830908 3.2704384396669486 -2.7024209359690152 184 148.0 463 0 1 True 6185 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k38596918 BRD-K38596918 BRD-K38596918 12 3 HEPG2;HUH7;PHH 0.11808906826708045 0.054545178802476946 -0.05888330404247555 0.00082389963790775 -0.24732115758316855 -0.18954764309501834 -0.6073845641924038 0.25 1 0.11808906826708045 0.11808906826708045 -0.24732115758316855 -0.24732115758316855 False False -0.4932399251912203 1.2043054415805987 -0.7322026563114679 1.243155325990796 185 241.0 304 0 0 True 6620960 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +wortmannin wortmannin BRD-A11678676;BRD-A75409952;BRD-K87343924 44 3 HEPG2;HUH7;PHH -0.0087442565709352 -0.22216689955287922 0.035606165017400396 0.0918864351697266 -0.0344450837001204 -0.13097483964197126 -0.5818420401183031 0.22727272727272727 3 -0.3176684023346752 0.1721763776408301 -0.3502416979255421 0.0602596402168273 True True -0.4218958597011228 1.1987905133999037 0.36717287360348444 -0.4431316062789231 186 280.0 298 0 1 True True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a44244100 BRD-A44244100 BRD-A44244100 12 3 HEPG2;HUH7;PHH 0.0831218204564518 -0.060231493242705804 0.0372539971555982 0.07045556046068666 -0.042948375189942954 -0.0477996528710401 -0.3510247203318165 0.16666666666666666 1 0.0831218204564518 0.0831218204564518 -0.042948375189942954 -0.042948375189942954 False False -0.22331201303694834 1.1984784862720246 0.2862742798076963 0.6578949215378086 187 195.0 204 0 0 True 18574628 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sa-792709 SA-792709 BRD-K51290057 3 2 HEPG2;PHH -0.0507467225607898 -0.2097614180917541 0.0573821163603237 0.608403155580163 0.0573821163603237 0.2821459134094535 0.0642374455854888 0.0 1 -0.0507467225607898 -0.0507467225607898 0.0573821163603237 0.0573821163603237 False False 0.3142646362021979 1.1828875246558817 2.211369336800427 -0.676209938726668 188 75.0 293 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +protriptyline protriptyline BRD-K42098891 3 2 HEPG2;PHH 0.1437321371502346 -0.05040476181440884 -0.2439999899693898 0.0966937812045216 -0.2439999899693898 -0.4969600244787418 -0.5905773872971565 0.3333333333333333 1 0.1437321371502346 0.1437321371502346 -0.2439999899693898 -0.2439999899693898 False False -0.7922487181273201 1.159898032591737 -0.9905124346900211 1.0809413635006426 189 264.0 395 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +arp-101 ARP-101 BRD-K73395020 3 2 HEPG2;PHH -0.4756717913680606 -0.5700076510094934 0.0042587167450359 0.164033330976963 0.0042587167450359 -0.4147170354974352 -0.7553752242450764 0.3333333333333333 1 -0.4756717913680606 -0.4756717913680606 0.0042587167450359 0.0042587167450359 False False -0.7924046476199734 1.1596286797135547 0.5881712375928116 -4.553201169103641 190 561.0 572 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +bupropion bupropion BRD-A05186015 3 2 HEPG2;PHH -0.28196938501464 -0.35285969202717143 0.9436982614653452 0.1753329206258058 0.1753329206258058 0.2775462060309355 0.0341116037471072 0.0 1 -0.28196938501464 -0.28196938501464 0.1753329206258058 0.1753329206258058 False False 0.2946020079044891 1.148922266163113 3.868154006594056 -2.620352803339582 191 78.0 466 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +salmeterol salmeterol BRD-A01320529 3 2 HEPG2;PHH 0.0362750026914808 -0.022105488098329955 -0.13575887839709 -0.289035927504301 -0.289035927504301 -0.5006396801373552 -0.6135384766163215 0.3333333333333333 1 0.0362750026914808 0.0362750026914808 -0.289035927504301 -0.289035927504301 False False -0.807408918445516 1.1337102760612594 -1.9353046560744844 0.47389250354061574 192 505.0 533 0 1 True 5152 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +zm-447439 ZM-447439 BRD-K72703948 9 2 HEPG2;PHH -0.0492926024728351 -0.1008101089133156 0.0751696931464331 0.0834658723324537 0.03604485307421 -0.0346265967846626 -0.099069506665396 0.1111111111111111 1 -0.0492926024728351 -0.0492926024728351 0.03604485307421 0.03604485307421 False False -0.0841613501173606 1.1241136495673019 0.6406300136931953 -0.3260891678476357 193 310.0 354 0 1 True 9914412 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a36411721 BRD-A36411721 BRD-A36411721 12 3 HEPG2;HUH7;PHH -0.0514711127099063 -0.13451253301981414 0.14207548222371505 0.33804446179419756 0.0755794729505266 0.16523637346893777 -0.3172967959757126 0.08333333333333333 1 -0.0514711127099063 -0.0514711127099063 0.0755794729505266 0.0755794729505266 False False 0.006587975481081476 1.1235072257032945 1.7028740139725826 -0.44558316305966994 194 129.0 269 0 0 True 3150672 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k22033393 BRD-K22033393 BRD-K22033393 12 3 HEPG2;HUH7;PHH 0.08790839530734551 -0.1943981467435757 -0.07689173306737626 0.0080347610637545 -0.07689173306737626 -0.11646870901394216 -0.30871034060634434 0.16666666666666666 1 0.08790839530734551 0.08790839530734551 -0.07689173306737626 -0.07689173306737626 False False -0.2708238793171143 1.1164064054064298 -0.3284257800260682 0.26931622302976566 195 284.0 332 0 0 True 54654536 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fccp FCCP BRD-K14821540 14 3 HEPG2;HUH7;PHH 0.11587668665581274 -0.006537437542445103 0.01542561181953975 0.2201725479681044 -0.13606258481740952 -0.186158133195787 -0.48252128555794205 0.21428571428571427 1 0.11587668665581274 0.11587668665581274 -0.13606258481740952 -0.13606258481740952 False False -0.427418775974758 1.1156760515336441 0.4303630637797458 1.0378197441928814 196 113.0 190 0 1 True 3330 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +a-23187 A-23187 BRD-K41431477 11 3 HEPG2;HUH7;PHH 0.0904777807494004 -0.12426657084789541 0.1433857242975916 -0.1222287099808454 -0.1335124969482422 -0.1048543509982881 -0.44195417292501094 0.18181818181818182 1 0.0904777807494004 0.0904777807494004 -0.1335124969482422 -0.1335124969482422 False False -0.32583143746079357 1.10722278106058 -0.2041935588650586 0.5052601869291359 197 216.0 405 0 0 True 11957499;40486 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +calcitriol calcitriol BRD-A84327315;BRD-K27316855 3 2 HEPG2;PHH -0.0643086050533586 -0.2168049422196216 0.4818291249019759 0.110016519203782 0.110016519203782 0.2316142169995203 0.07303102044684309 0.0 2 -0.2168049422196216 0.289318526784579 -0.171427452138492 0.35021175803350546 True True 0.26812972722294187 1.1031940022388724 2.1249927071981967 -0.7860191391633258 198 108.0 315 0 1 True 21158442;5283740;73707427 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k47977047 BRD-K47977047 BRD-K47977047 12 3 HEPG2;HUH7;PHH -0.1583856190037396 -0.2711063516843649 0.1707260959914752 0.13733490020968014 0.0235782064763563 -0.10228934042924451 -0.3676566927322364 0.16666666666666666 1 -0.1583856190037396 -0.1583856190037396 0.0235782064763563 0.0235782064763563 False False -0.2861176867953627 1.0899878556341254 1.0554470316578746 -1.5647674188000935 199 347.0 454 0 0 True 54650155 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +etodolac etodolac BRD-A16998493;BRD-A74667430;BRD-K99260425 5 2 HEPG2;PHH 0.0314040134350458 0.0179630617300669 0.0579071438738277 0.0657437592744827 -0.1889625191688537 -0.2394159179299123 -0.3248605298854056 0.2 3 -0.0153333412276373 0.0820797830820083 -0.23619035551590575 0.11028439179062846 True True -0.4018461828726151 1.078918610255603 -0.03965668955124943 0.5676646271190695 200 233.0 258 0 1 True 667528;73707528 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pd-184352 PD-184352 BRD-K05104363 3 2 HEPG2;PHH 0.2852154970169067 0.20088304910394875 -0.066848914538111 -0.0476405108347535 -0.1018106751143932 0.2011884940522057 0.10266268293425021 0.0 1 0.2852154970169067 0.2852154970169067 -0.1018106751143932 -0.1018106751143932 False False 0.2525198355193308 1.0762294480231445 -0.5286030157303664 2.782548756150072 201 121.0 223 1 1 True 6918454 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +danazol danazol BRD-A20243730;BRD-A92537424;BRD-K48970916 6 2 HEPG2;PHH 0.16171135939657685 0.13243951886478394 -0.09389017655381135 0.07845517015084624 -0.16306056501343846 -0.3346139790105914 -1.016592621345014 0.3333333333333333 3 0.1406286385738187 0.7121076153384315 -0.36105760080473764 0.2349436804652214 False True -0.8429102896830984 1.0723851453271993 -0.3891879962565308 1.7691007437107213 202 170.0 244 0 1 True 6540825 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +atorvastatin atorvastatin BRD-U88459701 13 3 HEPG2;HUH7;PHH 0.2072999146249559 0.1362054027203056 -0.0331866379295076 0.1084328517317771 -0.1188452158655439 -0.0523474000704785 -0.4095230520008102 0.15384615384615385 1 0.2072999146249559 0.2072999146249559 -0.1188452158655439 -0.1188452158655439 False False -0.2571089260708836 1.0674667315242699 -0.00496416575996755 2.075961514835675 203 97.0 163 0 1 True 2250;60823 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cisapride cisapride BRD-K06895174 3 2 HEPG2;PHH 0.227401551273134 0.007988593230644853 0.4427635744214058 -0.1414390266872942 -0.1414390266872942 0.1669758489828497 0.159645153719577 0.0 1 0.227401551273134 0.227401551273134 -0.1414390266872942 -0.1414390266872942 False False 0.2467984258426382 1.0663462749463013 0.6130989489933757 1.8051198264586321 204 41.0 274 3 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +zstk-474 ZSTK-474 BRD-K63068307 3 2 HEPG2;PHH 0.0721813895636134 -0.0747069704035918 0.2424535410744803 -0.1635907553136348 -0.1635907553136348 -0.4165547303264103 -0.86293800440543 0.3333333333333333 1 0.0721813895636134 0.0721813895636134 -0.1635907553136348 -0.1635907553136348 False False -0.8480237325291253 1.0635521752164059 -0.1086371398546871 0.5418128403364286 205 204.0 458 0 1 True 11647372 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +equilin equilin BRD-A88080608;BRD-K04046242 10 2 HEPG2;PHH 0.13199809597184256 0.04964407642061507 0.0099655134337289 -0.034432284533977446 -0.1348295682109892 -0.21028384730766805 -0.4064731320203651 0.2 2 0.13199809597184256 0.25334748398098683 -0.233951233726527 -0.0400938077364117 False False -0.4135204133178506 1.0587525241773355 -0.3439576952050224 1.317858714391492 206 198.0 276 0 1 True 223368;73707480 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k32581454 BRD-K32581454 BRD-K32581454 12 3 HEPG2;HUH7;PHH -0.06436553080048821 -0.26049801489959157 0.08786552825144354 0.2214823218528181 0.0358295823846544 0.0440886619146026 -0.152826907641683 0.08333333333333333 1 -0.06436553080048821 -0.06436553080048821 0.0358295823846544 0.0358295823846544 False False -0.032324791906238895 1.0562892432968773 1.0906402173643077 -0.9230229999774171 207 237.0 337 0 0 True 54657690 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ru-24969 RU-24969 BRD-K00234327 4 2 HEPG2;PHH 0.03586883110822075 -0.12806325178179473 -0.0591047762760094 0.174025472253561 -0.11768208237897065 -0.28839681297910236 -0.5826267080976524 0.25 1 0.03586883110822075 0.03586883110822075 -0.11768208237897065 -0.11768208237897065 False False -0.5797101670279285 1.0549365946773475 0.11662040586567737 0.13991616936492918 208 231.0 327 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fenretinide fenretinide BRD-K28168037;BRD-K89085489 6 2 HEPG2;PHH -0.268410675227642 -0.37047460033661783 0.05330357328057285 0.35209237318485975 0.05330357328057285 -0.12151342785976356 -0.3990113837515107 0.16666666666666666 2 -0.2997548551195197 -0.2198805546181069 -0.025291652019534802 0.05330357328057285 False True -0.3210191197355189 1.029699059363763 1.4224887554733998 -2.5876750954461536 210 416.0 521 0 1 True 5288209;5353342 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k82987299 BRD-K82987299 BRD-K82987299 11 3 HEPG2;HUH7;PHH 0.03876610348622 -0.16753497988813446 0.2782727607658931 0.266917647793889 -0.0198302865028381 -0.2054593644681431 -0.35541519654973863 0.18181818181818182 1 0.03876610348622 0.03876610348622 -0.0198302865028381 -0.0198302865028381 False False -0.38316696274301243 1.0081812944625674 1.6532918789319124 0.03523498952017717 211 76.0 130 0 0 True 1645763 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k09701578 BRD-K09701578 BRD-K09701578 12 3 HEPG2;HUH7;PHH -0.14912898031373817 -0.2375134696356124 -0.032531033669199294 0.24607235100120306 -0.0404747340029904 -0.1298407834052803 -0.41617394822265297 0.16666666666666666 1 -0.14912898031373817 -0.14912898031373817 -0.0404747340029904 -0.0404747340029904 False False -0.33792775751660675 1.0004910489035252 0.6089919703840483 -1.3998008815734744 212 392.0 459 0 0 True 54654332 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +zk-93423 ZK-93423 BRD-K33882852 14 3 HEPG2;HUH7;PHH -0.16734469806154564 -0.33026732659588254 0.15547568723559374 0.3662552749738097 0.12167388879294899 0.0430871659431547 -0.1395257615358642 0.07142857142857142 1 -0.16734469806154564 -0.16734469806154564 0.12167388879294899 0.12167388879294899 False False -0.02667571482477741 0.9986044828348457 1.9452080571209018 -1.8077635344147414 213 230.0 427 0 1 True 121926 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +amg-9810 AMG-9810 BRD-K43068349 3 2 HEPG2;PHH -0.1117749984065691 -0.19701757737331915 0.0723214455481086 0.3748375019058585 0.0723214455481086 0.1642266825831953 0.08436245542936141 0.0 1 -0.1117749984065691 -0.1117749984065691 0.0723214455481086 0.0723214455481086 False False 0.20640791029787603 0.9965756277895379 1.595999756431093 -1.0313798588686065 214 203.0 377 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ski-ii SKI-II BRD-K20755323 3 2 HEPG2;PHH -0.3619214968962801 -0.4181562774918145 0.3110185733863285 0.558755548670888 0.3110185733863285 0.1901766299196179 0.03180054198980101 0.0 1 -0.3619214968962801 -0.3619214968962801 0.3110185733863285 0.3110185733863285 False False 0.2060769009145184 0.9960038416021043 3.4701511740832736 -3.3420575556368903 215 260.0 533 0 1 True 753704 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k55082668 BRD-K55082668 BRD-K55082668 12 3 HEPG2;HUH7;PHH -0.2553570158779621 -0.3867039619427588 0.22021778885807305 0.3855279525741935 0.17654459018792418 -0.0012831906566307498 -0.13982048000408603 0.08333333333333333 1 -0.2553570158779621 -0.2553570158779621 0.17654459018792418 0.17654459018792418 False False -0.07119343065867377 0.9891474887715007 2.3367648009269324 -2.553933631463477 216 291.0 494 0 0 True 54654200 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +deracoxib deracoxib BRD-K68558722 3 2 HEPG2;PHH 0.4256833286748992 0.30950209581189686 -0.4863999996866499 -0.3774437494575977 -0.4863999996866499 -0.5705462446111061 -0.6531923950191527 0.3333333333333333 1 0.4256833286748992 0.4256833286748992 -0.4863999996866499 -0.4863999996866499 False False -0.8971424421206825 0.9787044304058675 -3.7528317716970467 4.03143427877933 217 350.0 540 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k74548617 BRD-K74548617 BRD-K74548617 12 3 HEPG2;HUH7;PHH -0.03281558061846425 -0.1002639908757474 0.1133935355714389 0.2864209418185055 -0.0028297061217017498 0.06763423727095375 -0.2973857981093701 0.08333333333333333 1 -0.03281558061846425 -0.03281558061846425 -0.0028297061217017498 -0.0028297061217017498 False False -0.0810586617837313 0.9721062712811346 1.262181432940587 -0.21772939348753087 218 151.0 260 0 0 True 54657899 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tacrolimus tacrolimus BRD-K08845546;BRD-K65261396;BRD-K69608737 5 2 HEPG2;PHH -0.0491468322773774 -0.1979009940599402 0.4040428485189165 -0.0069055184721946 -0.0069055184721946 0.1837550858922657 0.0031175813859417 0.0 3 -0.921250025017394 0.1384000062114662 -0.0186687484383583 0.6557823643088341 True True 0.18531387658523654 0.9601377570808465 1.243749706753139 -0.6287647285564251 219 174.0 429 0 1 True 13819073;24140138;6473866 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +bay-11-7082 BAY-11-7082 BRD-K15025317 3 2 HEPG2;PHH -0.0367504540416929 -0.3240391148461236 0.1508263455969946 0.2236877121031284 0.1508263455969946 0.1505065748083686 0.0674957573036885 0.0 1 -0.0367504540416929 -0.0367504540416929 0.1508263455969946 0.1508263455969946 False False 0.18425445346021285 0.9583077077227532 1.5796854429831702 -0.9429803829444197 220 174.0 273 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +glycocholic-acid glycocholic-acid BRD-K54771420 3 2 HEPG2;PHH 0.2927055549290445 0.11361296104991603 -0.1485714369586535 0.098981250077486 -0.1485714369586535 0.1497230490240904 0.060519427419566243 0.0 1 0.2927055549290445 0.2927055549290445 -0.1485714369586535 -0.1485714369586535 False False 0.1799827627338735 0.950928781694935 -0.4542248684959919 2.5581223219077263 221 81.0 182 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +phenazone phenazone BRD-K46937689 15 3 HEPG2;HUH7;PHH 0.0671499677830272 -0.06411816738545895 0.0649642710174833 -0.165404325351119 -0.165404325351119 -0.2003810447049401 -0.5511226232740141 0.2 1 0.0671499677830272 0.0671499677830272 -0.165404325351119 -0.165404325351119 False False -0.47594235634194715 0.9509247506806783 -0.6493110077417679 0.5423585251324216 222 323.0 461 0 1 True 98889 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +chlorambucil chlorambucil BRD-K29458283 3 2 HEPG2;PHH 0.3111125388079219 0.19690765957865444 -0.4790000064032418 0.0537214018404483 -0.4790000064032418 -0.5642941155663086 -0.7057329971225016 0.3333333333333333 1 0.3111125388079219 0.3111125388079219 -0.4790000064032418 -0.4790000064032418 False False -0.9171606141275594 0.9441250050883728 -2.4227885748082905 2.9377426589690803 223 223.0 451 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +entinostat entinostat BRD-K77908580 9 2 HEPG2;PHH -0.3489397687630521 -0.5397776845428679 0.3347965095724378 0.3415322825312614 0.3347965095724378 0.2547207708574003 -0.1589432042387742 0.0 1 -0.3489397687630521 -0.3489397687630521 0.3347965095724378 0.3347965095724378 False False 0.17524916873801322 0.9427519631519152 2.9526755321321563 -3.6383598712138396 224 355.0 538 0 1 True 4261 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k16956545 BRD-K16956545 BRD-K16956545 18 3 HEPG2;HUH7;PHH -0.04982988099153665 -0.2269834329684575 0.1965189214263643 0.1074997051618993 0.042350996551769104 -0.0357345087631118 -0.3318201724720734 0.1111111111111111 1 -0.04982988099153665 -0.04982988099153665 0.042350996551769104 0.042350996551769104 False False -0.2016445949991485 0.9211728869916229 1.0913938051771126 -0.7241314948964148 226 214.0 323 0 0 True 54645915 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +benzylpenicillin benzylpenicillin BRD-K55191674 3 2 HEPG2;PHH 0.2052153853906525 0.06507713766768575 0.379796890275819 -0.1360386665910482 -0.1360386665910482 0.1230364973464655 0.0771717130694361 0.0 1 0.2052153853906525 0.2052153853906525 -0.1360386665910482 -0.1360386665910482 False False 0.16162235388118357 0.9192129793478402 0.4548191295782668 1.8400391034700638 227 58.0 289 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +quetiapine quetiapine BRD-K68867920 3 2 HEPG2;PHH 0.0232236646115779 0.0100937620219257 -0.3328000051634652 0.1253250148147344 -0.3328000051634652 -0.6059736434872899 -0.6615708915901091 0.3333333333333333 1 0.0232236646115779 0.0232236646115779 -0.3328000051634652 -0.3328000051634652 False False -0.9367590892823444 0.9102705648468341 -1.3975912584787527 0.49010652125050463 229 434.0 523 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +irbesartan irbesartan BRD-K60038276 3 2 HEPG2;PHH 0.0170861060420672 -0.10861806012690065 0.1862298338674008 -0.0318874940276145 -0.0411635772325098 0.1813075482135727 -0.054738590477167504 0.0 1 0.0170861060420672 0.0170861060420672 -0.0411635772325098 -0.0411635772325098 False False 0.15393825297498895 0.9059394500102679 0.4302515708033272 0.07914820750462825 230 229.0 386 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +vemurafenib vemurafenib BRD-K56343971 3 2 HEPG2;PHH 0.2371266103453106 0.18129766359925265 -0.335922930921827 0.0429701432585716 -0.335922930921827 -0.6215482542202586 -0.63749213444276 0.3333333333333333 1 0.2371266103453106 0.2371266103453106 -0.335922930921827 -0.335922930921827 False False -0.9402943214416386 0.9041637986350979 -1.6611211291409067 2.410033742213608 231 236.0 392 0 1 True 42611257 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k31030218 BRD-K31030218 BRD-K31030218 12 3 HEPG2;HUH7;PHH 0.01468760313259225 -0.046799840819504473 -0.11323459286774905 0.1697582734050229 -0.1217239912865417 -0.1369893468910872 -0.5144359922398709 0.16666666666666666 1 0.01468760313259225 0.01468760313259225 -0.1217239912865417 -0.1217239912865417 False False -0.39420734301102267 0.9032735945408018 -0.06830156718226824 0.2569389449300187 232 293.0 391 0 0 True 96670 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nadolol nadolol BRD-A87606379;BRD-A97454584 5 2 HEPG2;PHH -0.0226581752714183 -0.0707583270139164 -0.16566130731787 0.0071312431246042 -0.2194562405347824 -0.3304585759631462 -0.3542522988429973 0.2 2 -0.0226581752714183 0.0475722190975729 -0.2194562405347824 -0.2137196242942342 True False -0.5075847253846448 0.8962656670838004 -0.9612695886555521 -0.05971380140960733 233 452.0 466 0 1 True 4411 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k52785744 BRD-K52785744 BRD-K52785744 12 3 HEPG2;HUH7;PHH -0.19929136097845102 -0.41269250441756516 0.2717013582587242 0.32480849046260113 0.22052148490079804 0.21317858477344825 -0.142116158117821 0.0 1 -0.19929136097845102 -0.19929136097845102 0.22052148490079804 0.22052148490079804 False False 0.14212050571453777 0.885525452734522 2.421671932814625 -2.2723039670007545 234 236.0 451 0 0 True 54650184 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sib-1893 SIB-1893 BRD-K67439147 15 3 HEPG2;HUH7;PHH 0.0061524411042531 -0.1905749505385756 0.0140640341809817 0.1301101818680763 -0.1716351328151566 -0.0554588966012473 -0.48092047286234674 0.13333333333333333 1 0.0061524411042531 0.0061524411042531 -0.1716351328151566 -0.1716351328151566 False False -0.2959191330324207 0.8842164592259802 0.06603209447119757 -0.24791550936267137 235 251.0 277 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +amiodarone amiodarone BRD-K17561142 4 2 HEPG2;PHH 0.18009033136897615 0.09849065195562107 -0.1368139561797891 0.29310999251902103 -0.1368139561797891 0.1165631076261874 0.02503292569484085 0.0 1 0.18009033136897615 0.18009033136897615 -0.1368139561797891 -0.1368139561797891 False False 0.12907957047360782 0.8629985184031003 0.19136344397381222 1.7818999369587702 237 89.0 257 1 1 True 16218975 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pregnenolone pregnenolone BRD-K39356024;BRD-K43880410 4 2 HEPG2;PHH 0.08625278984093 0.02647121077299945 0.0900558121502399 -0.1092259837314486 -0.25430432440979134 -0.35308516981257565 -0.6761052012037013 0.25 2 0.00028319910375610227 0.21071737383802724 -0.25430432440979134 -0.20177114828090584 False False -0.6911377704144264 0.8624563578062118 -0.6338085526305659 0.9492945205238285 238 254.0 396 0 1 True 15032;7088398;8955 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ropinirole ropinirole BRD-K15933101 3 2 HEPG2;PHH -0.3393166694376204 -0.45316944561070865 0.2526714418615614 0.0319687463343143 0.0319687463343143 0.1379445436159296 -0.029526015861876448 0.0 1 -0.3393166694376204 -0.3393166694376204 0.0319687463343143 0.0319687463343143 False False 0.12318153568499136 0.8528102427991697 1.0068973341492957 -3.3052336156724675 239 515.0 555 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tolmetin tolmetin BRD-K82562631 3 2 HEPG2;PHH 0.338411118214329 0.2263774295440978 -0.4937999972275325 -0.0703437514603138 -0.4937999972275325 -0.3987579892966009 -1.1457814772812918 0.3333333333333333 1 0.338411118214329 0.338411118214329 -0.4937999972275325 -0.4937999972275325 False False -0.9716487279372468 0.850002142045436 -2.8757989235019226 3.206596883289318 240 277.0 487 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +piperlongumine piperlongumine BRD-K24132293 4 2 HEPG2;PHH 0.133368793874979 0.03025529492232533 0.02562477346509695 -0.03671573055908085 -0.0880441623074667 0.15236294505718562 -0.06984714927366155 0.0 1 0.133368793874979 0.133368793874979 -0.0880441623074667 -0.0880441623074667 False False 0.11743937042035485 0.8428912164834303 -0.18426608354231 1.2660990318535434 241 192.0 262 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nitrendipine nitrendipine BRD-A02006392 4 2 HEPG2;PHH -0.044762117581235 -0.0661997133865952 0.2454386305596147 0.21230496466159815 0.07823857053049971 0.1655329104442711 -0.1194024451256227 0.0 1 -0.044762117581235 -0.044762117581235 0.07823857053049971 0.07823857053049971 False False 0.10583168788145975 0.8228400853749046 1.642782440998692 -0.18853200617518728 242 136.0 266 0 1 True 4507 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +vinpocetine vinpocetine BRD-A19374631;BRD-K53318339 4 2 HEPG2;PHH 0.046540860293640046 -0.0440120405207077 0.3034160658717156 0.00016072858124970002 -0.09770398733339135 0.13771751003399016 -0.06813262449207882 0.0 2 -0.024078237306740552 0.0968281835731533 -0.09770398733339135 -0.0797180152897324 True False 0.10365119778795075 0.819073502975766 0.7317315725802925 0.471835662432746 243 128.0 313 0 1 True 443955;5673;6978790 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fluvastatin fluvastatin BRD-K66296774 3 2 HEPG2;PHH 0.1513774866859118 0.022866518754098147 -0.0075945226209504 -0.0838062553666532 -0.1297142782381602 0.1213858976575826 -0.0445168495459098 0.0 1 0.1513774866859118 0.1513774866859118 -0.1297142782381602 -0.1297142782381602 False False 0.0991274728846277 0.8112592126700572 -0.5309719872913203 1.35955924651415 244 212.0 305 0 1 True 1548972 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +quipazine quipazine BRD-K77925998 3 2 HEPG2;PHH 0.0577972230191032 -0.09452499837304154 -0.0147714231695447 0.6342125069350004 -0.0147714231695447 0.2248710942055498 -0.25181699287708087 0.0 1 0.0577972230191032 0.0577972230191032 -0.0147714231695447 -0.0147714231695447 False False 0.09896259776700936 0.8109744071036729 1.888211019162939 0.38673321881030437 245 44.0 258 3 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gw-4064 GW-4064 BRD-K64245000 3 2 HEPG2;PHH -0.1177888876344594 -0.49653750738232494 0.5286857272897448 0.3259687460958957 0.3259687460958957 0.1088589679095007 -0.02076065540313715 0.0 1 -0.1177888876344594 -0.1177888876344594 0.3259687460958957 0.3259687460958957 False False 0.09847864020793212 0.8101384179701397 3.4632014776176434 -2.0069542522067305 246 65.0 274 1 1 True 9893571 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +diethylstilbestrol diethylstilbestrol BRD-K45330754 9 2 HEPG2;PHH 0.0170977197380529 -0.0455447638200389 -0.014611291033881 -0.0033053448423743 -0.0823820786816733 -0.1579665643355203 -0.2280137859107482 0.1111111111111111 1 0.0170977197380529 0.0170977197380529 -0.0823820786816733 -0.0823820786816733 False False -0.2719734572908944 0.7996866873303183 -0.1901848771498097 0.2764639068590118 247 331.0 350 0 1 True 448537 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cgp-53353 CGP-53353 BRD-K32292990 14 3 HEPG2;HUH7;PHH -0.10035238528831134 -0.28258981607440437 0.0492898779256003 0.21532418066635725 0.009433914109000099 -0.025810166202958548 -0.2449835094360871 0.07142857142857142 1 -0.10035238528831134 -0.10035238528831134 0.009433914109000099 0.009433914109000099 False False -0.14830192092100208 0.788507161815235 0.8893712540641767 -1.225042314522763 248 307.0 398 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k07339740 BRD-K07339740 BRD-K07339740 12 3 HEPG2;HUH7;PHH -0.0408679019245836 -0.3730920807768901 0.13936958987531917 0.12422878947108978 0.0008713628298469998 -0.03623829529960711 -0.3055747171285532 0.08333333333333333 1 -0.0408679019245836 -0.0408679019245836 0.0008713628298469998 0.0008713628298469998 False False -0.1890256538638837 0.7856039004299102 0.8644268960008761 -1.1230283338310065 249 235.0 319 0 0 True 54657692 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +venlafaxine venlafaxine BRD-A51714012 3 2 HEPG2;PHH 0.0699305575754907 0.007867801520559548 0.3369129853589194 -0.1483187368139624 -0.1483187368139624 0.0613029974971025 -0.0014037637867861455 0.0 1 0.0699305575754907 0.0699305575754907 -0.1483187368139624 -0.1483187368139624 False False 0.06060111560370943 0.7447087157569042 0.25848450849857285 0.7854685568514921 250 156.0 447 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k36111658 BRD-K36111658 BRD-K36111658 12 3 HEPG2;HUH7;PHH 0.0039324144729309 -0.07558622149129701 -0.04707929332341465 0.1891385125927627 -0.1261370456112282 -0.02997409301026465 -0.37044790573972497 0.08333333333333333 1 0.0039324144729309 0.0039324144729309 -0.1261370456112282 -0.1261370456112282 False False -0.21519804588012714 0.7403936647103363 0.1761195442903635 0.09730335524731996 251 256.0 341 0 0 True 855012 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ku-55933 KU-55933 BRD-K25311561 4 2 HEPG2;PHH -0.13570798245362106 -0.25992045761086047 0.22080711860741886 -0.09092385275289416 -0.09092385275289416 -0.38481433553591604 -0.760845151419441 0.25 1 -0.13570798245362106 -0.13570798245362106 -0.09092385275289416 -0.09092385275289416 False False -0.7652369112456365 0.7344573724051918 0.22981463619195364 -1.3830001691942546 252 425.0 517 0 1 True 5278396 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +forskolin forskolin BRD-A70449690;BRD-K03015355;BRD-K09602097;BRD-K77830450 9 2 HEPG2;PHH 0.1669938125544124 0.0792237288422054 -0.2734132281371525 0.1091191978193819 -0.2734132281371525 -0.4142763001829504 -0.5466019816785342 0.2222222222222222 4 0.0792237288422054 0.2720872975058025 -0.715468306094408 0.0848562233150005 False True -0.6875772910222175 0.7112397685948774 -1.1165542856055999 1.6368783582485475 253 246.0 400 0 1 True 3413;9871875 True True True mechanistic_probe_only cAMP/PKA probe; conflicts with reported PKA-RUNX2 activation False Tier_4_not_prioritized +brd-k00069117 BRD-K00069117 BRD-K00069117 12 3 HEPG2;HUH7;PHH -0.0156529497665663 -0.16088836531465248 0.12657657851065907 -0.010743318125605597 -0.12353985663503411 -0.16823404167394435 -0.6861263070447696 0.16666666666666666 1 -0.0156529497665663 -0.0156529497665663 -0.12353985663503411 -0.12353985663503411 False False -0.5112971951963292 0.7010123791966958 0.10436099510400214 -0.29622197711755294 254 296.0 402 0 0 True 54649961 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +puromycin puromycin BRD-A28970875;BRD-K36007650 3 2 HEPG2;PHH 0.091585920088821 -0.0954871949636274 0.080182066985539 0.2487799655646085 -0.0955577194690704 0.0248604639329844 0.018405789113973052 0.0 2 -0.0691190502709813 0.091585920088821 -0.0955577194690704 -0.04981521849653551 True False 0.03406335848997093 0.6988673477292401 0.8131132461060003 0.602430739436246 255 94.0 159 0 1 True 23618032;5702164 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brazilin brazilin BRD-A83326220 3 2 HEPG2;PHH -0.1618138847665654 -0.2709485374184118 0.3613357245922088 0.1969562545418739 0.1969562545418739 0.0392499498963828 -0.012392996004708744 0.0 1 -0.1618138847665654 -0.1618138847665654 0.1969562545418739 0.1969562545418739 False False 0.03305345189402843 0.6971228333100392 2.2471244953571263 -1.5864642837517353 256 200.0 414 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +azd-6482 AZD-6482 BRD-K58772419 4 2 HEPG2;PHH 0.1140078153047297 -0.1169611845786372 -0.2441212210272039 0.1135281242895871 -0.2441212210272039 -0.5062760077657118 -0.5808775108196728 0.25 1 0.1140078153047297 0.1140078153047297 -0.2441212210272039 -0.2441212210272039 False False -0.7967147631755482 0.6800824759565249 -0.9408580315968569 0.6804098294425579 258 290.0 418 0 1 True 44137675 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +prednisolone-hemisuccinate prednisolone-hemisuccinate BRD-A78391468 3 2 HEPG2;PHH 0.2961805624266465 -0.10728660500090986 0.082414299249649 0.084087498486042 -0.0356071325285094 0.0441291916908489 -0.0471818206521372 0.0 1 0.2961805624266465 0.2961805624266465 -0.0356071325285094 -0.0356071325285094 False False 0.020538281364780298 0.675504105860641 0.48081939137854285 1.8898261283841342 259 45.0 81 3 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +piroxicam piroxicam BRD-A57382968 3 2 HEPG2;PHH 0.0119722204075919 -0.042608337011188255 -0.0010500039373125 0.0493374802172184 -0.0234714363302503 0.0401450380801208 -0.039658994450869546 0.0 1 0.0119722204075919 0.0119722204075919 -0.0234714363302503 -0.0234714363302503 False False 0.020315540854686027 0.675119343514142 0.15846259269061067 0.25247041573029877 260 301.0 303 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +talampicillin talampicillin BRD-A10303790 3 2 HEPG2;PHH -0.070546513216363 -0.1366630738549348 0.441590747662953 -0.017012495547533 -0.017012495547533 0.0346657040691564 -0.033480175641468844 0.0 1 -0.070546513216363 -0.070546513216363 -0.017012495547533 -0.017012495547533 False False 0.01792561624842198 0.670990983571568 1.2999260762043228 -0.5757789378088224 261 178.0 454 0 1 True 73707484 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +amlodipine amlodipine BRD-A22032524 3 2 HEPG2;PHH 0.5087555502023962 0.15548471837408012 -0.3086285803999219 0.2711560446768999 -0.3086285803999219 0.0249075899491944 -0.017437635551369398 0.0 1 0.5087555502023962 0.5087555502023962 -0.3086285803999219 -0.3086285803999219 False False 0.016188772173509704 0.6679907560804699 -0.8275170249807009 4.087504106068789 262 11.0 136 3 1 True 60496 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k89205986 BRD-K89205986 BRD-K89205986 12 3 HEPG2;HUH7;PHH -0.04615935610814225 -0.2339456618970467 -0.0028392959918294505 0.15540047641843552 -0.09637525358370365 -0.27147798626018416 -0.5238839179898303 0.16666666666666666 1 -0.04615935610814225 -0.04615935610814225 -0.09637525358370365 -0.09637525358370365 False False -0.5334199452550993 0.6627975020734481 0.28366343249626697 -0.7221450613168178 263 309.0 348 0 0 True 1220374 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a13020530 BRD-A13020530 BRD-A13020530 12 3 HEPG2;HUH7;PHH -0.38164549279544085 -0.428627762529585 0.22744896369321 0.3182178335264325 0.18024695332029034 -0.0840579769426276 -0.3556922323898309 0.08333333333333333 1 -0.38164549279544085 -0.38164549279544085 0.18024695332029034 0.18024695332029034 False False -0.26190409313754304 0.659713557033254 2.16662893853523 -3.5024724944058496 264 435.0 554 0 0 True 1543530 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +duloxetine duloxetine BRD-K71103788 4 2 HEPG2;PHH 0.21852189468012911 0.1440896673334969 0.1606272576110703 -0.0665861084125936 -0.0665861084125936 0.15588777435440865 -0.3005726069234134 0.0 1 0.21852189468012911 0.21852189468012911 -0.0665861084125936 -0.0665861084125936 False False 0.005601470892701937 0.6497022333408441 0.18493302996736238 2.1732541979990767 265 83.0 206 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ym-90709 YM-90709 BRD-K06712146 3 2 HEPG2;PHH -0.1780928174654642 -0.1823518260692556 0.2036523137773786 0.1600942518562078 0.0509002497419714 0.0073152563667723 -0.007063523278616 0.0 1 -0.1780928174654642 -0.1780928174654642 0.0509002497419714 0.0509002497419714 False False 0.0037834947274643003 0.6465618581350949 1.2918270168114845 -1.4147776468416717 266 337.0 467 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k09191212 BRD-K09191212 BRD-K09191212 3 2 HEPG2;PHH 0.0379224510656462 0.01845655942128765 -0.0448925037469182 0.4256174899637699 -0.0448925037469182 0.2005022843959667 -0.39545033224267023 0.0 1 0.0379224510656462 0.0379224510656462 -0.0448925037469182 -0.0448925037469182 False False 0.0027771182746315903 0.6448234416912728 1.0974916859937727 0.6114002231832019 267 109.0 309 1 0 True 1208412 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k86336638 BRD-K86336638 BRD-K86336638 12 3 HEPG2;HUH7;PHH -0.03654592256579125 -0.14336491572774113 0.10743466338941024 0.0398797718808055 -0.024264378240331952 0.006123187049986847 -0.5587460898502272 0.08333333333333333 1 -0.03654592256579125 -0.03654592256579125 -0.024264378240331952 -0.024264378240331952 False False -0.2732498578751268 0.6401148631925595 0.45247923086919056 -0.376658689489914 268 300.0 362 0 0 True 54654199 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +xe-991 XE-991 BRD-K42748308 3 2 HEPG2;PHH -0.1017161004969643 -0.24032333066376546 0.2455041302101952 0.1468816548585891 0.1468816548585891 -0.0014006471379645 -0.010561536916250702 0.0 1 -0.1017161004969643 -0.1017161004969643 0.1468816548585891 0.1468816548585891 False False -0.006681415596089851 0.628484753748975 1.6230209643477047 -1.1016951079729127 269 228.0 375 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sirolimus sirolimus BRD-A23770159;BRD-A79768653;BRD-K84937637;BRD-K89626439;BRD-K99369265 16 2 HEPG2;PHH -0.23724646814581415 -0.5902048776236674 0.22042159895811755 0.23303464194759724 0.1082266373559832 -0.20547798805175316 -0.4379374424904762 0.125 5 -0.6254354097569983 0.13139334031277228 -0.4289860640253339 0.2579366033896804 True True -0.42444670929699124 0.6149876090524095 1.70669196277203 -3.073088909321128 270 354.0 498 0 1 True 44634693;5282071;5284616;73438890;73707374 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +spiramide spiramide BRD-K94512704 14 3 HEPG2;HUH7;PHH 0.31276151579287315 0.23635663014526165 -0.0018887354859283998 -0.10376191511750214 -0.2933904888174895 0.0795266233783747 -0.6699977446779875 0.07142857142857142 1 0.31276151579287315 0.31276151579287315 -0.2933904888174895 -0.2933904888174895 False False -0.25547224896061904 0.603380949820242 -0.9923506726970772 3.0717794990458556 271 87.0 193 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ki-8751 KI-8751 BRD-K47150025 12 3 HEPG2;HUH7;PHH 0.04641076736152165 -0.10251405079745579 0.17199270374008585 -0.0673795714974403 -0.18820786569267509 -0.23362970663352856 -0.6683835900972582 0.16666666666666666 1 0.04641076736152165 0.04641076736152165 -0.18820786569267509 -0.18820786569267509 False False -0.5678215016821577 0.6033721933656211 -0.09464010283992479 0.2880482342452008 272 222.0 393 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nafadotride nafadotride BRD-A71262238 3 2 HEPG2;PHH -0.005612276494503 -0.14435942843556399 0.214550854904311 -0.1341995541006326 -0.1341995541006326 0.0711004151593125 -0.1865649229832112 0.0 1 -0.005612276494503 -0.005612276494503 -0.1341995541006326 -0.1341995541006326 False False -0.022182046332293107 0.6017089371193414 -0.02898752929568313 -0.1795423152920776 273 304.0 489 0 1 True 3408722 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dactinomycin dactinomycin BRD-A73909368;BRD-K70578146 3 2 HEPG2;PHH -0.9530805672208468 -0.9911597151723175 1.3137428505080089 0.5282703153789043 0.5282703153789043 0.1315776784091241 -0.3135023437558659 0.0 2 -0.9911597151723175 -0.8465324830677774 0.5282703153789043 0.6023594010621309 False False -0.025173493468808844 0.5965415061065175 6.932557618603571 -8.960369875731011 274 378.0 575 1 1 True 457193 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +kenpaullone kenpaullone BRD-K37312348 13 3 HEPG2;HUH7;PHH -0.2723160104619132 -0.442863631579611 0.672926779304232 0.7292020358145237 0.3926863521337509 0.1614675803908279 -0.8778614224274717 0.07692307692307693 1 -0.2723160104619132 -0.2723160104619132 0.3926863521337509 0.3926863521337509 False False -0.27746313082290797 0.5965213940904615 5.270602135216851 -2.8393257877260423 275 27.0 383 3 1 True 3820 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +desipramine desipramine BRD-K60762818 3 2 HEPG2;PHH -0.0468939625554614 -0.0857907194230291 0.073685986655099 0.2425645501352846 0.073685986655099 0.0023598295030376 -0.06499260045506709 0.0 1 -0.0468939625554614 -0.0468939625554614 0.073685986655099 0.073685986655099 False False -0.030136470724495948 0.5879684505194988 1.2081345992255148 -0.2635952326494284 276 205.0 312 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +alitretinoin alitretinoin BRD-K35483542 3 2 HEPG2;PHH -0.2159124227861563 -0.33058308396074504 0.2989432151828493 0.125994483474642 0.125994483474642 -0.0023535872026094 -0.056517502211684646 0.0 1 -0.2159124227861563 -0.2159124227861563 0.125994483474642 0.125994483474642 False False -0.030612338308451722 0.5871464360231321 1.6668949181137571 -2.123118674137708 277 346.0 484 0 1 True 449171 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +estradiol estradiol BRD-A18917088;BRD-A23226398;BRD-K18910433 19 2 HEPG2;PHH 0.030981784272525 -0.02443236764520405 -0.1792571480785097 0.0480999816209077 -0.2200681822640555 -0.5071775963260157 -0.7875784566064202 0.2631578947368421 3 -0.00273478455427615 0.3019430515252881 -0.29336070389087715 0.0576618909835815 True True -0.9009668246292257 0.5745395305442124 -0.8810028089656422 0.4323541844117681 278 381.0 434 0 1 True 5757;628698 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +famciclovir famciclovir BRD-K45033733 3 2 HEPG2;PHH -0.1377574113818506 -0.2581717620034598 0.2477071327822549 0.362393744289875 0.2188714189188821 -0.0141347728906169 -0.057272267457659454 0.0 1 -0.1377574113818506 -0.1377574113818506 0.2188714189188821 0.2188714189188821 False False -0.04277090661944663 0.5661437038689039 2.458081088985303 -1.3907971938772132 279 149.0 373 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ketotifen ketotifen BRD-K28936863 4 2 HEPG2;PHH 0.03908244401423465 -0.037581291799950955 0.1382464385990585 -0.26305312290787697 -0.26305312290787697 -0.5039524738011616 -0.7178846245875494 0.25 1 0.03908244401423465 0.03908244401423465 -0.26305312290787697 -0.26305312290787697 False False -0.8628947860949363 0.5657629886794203 -0.9719980122528482 0.4436690531684579 280 366.0 515 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +thiorphan thiorphan BRD-A56012032 3 2 HEPG2;PHH -0.0100376688771777 -0.058607273476405194 0.3049079041395868 -0.0160096837207674 -0.1373782604932785 -0.0108537305042975 -0.0686789464745079 0.0 1 -0.0100376688771777 -0.0100376688771777 -0.1373782604932785 -0.1373782604932785 False False -0.045193203741551446 0.5619594235858775 0.5863396780093194 0.059974168881658865 281 189.0 400 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mrs-1334 MRS-1334 BRD-A06784547 3 2 HEPG2;PHH 0.179320072548257 -0.12006107821232737 0.2504428779440267 -0.0287249945104122 -0.0287249945104122 -0.0177936045053814 -0.06263705310116091 0.0 1 0.179320072548257 0.179320072548257 -0.0287249945104122 -0.0287249945104122 False False -0.049112131055961857 0.5551898616924743 0.6634987780986022 1.093467177983436 282 73.0 207 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sa-1973497 SA-1973497 BRD-K45356824 12 3 HEPG2;HUH7;PHH -0.12925522774457926 -0.3335312374143136 0.03608922873224531 0.2658032588660717 0.03608922873224531 -0.1564541103000501 -0.34277013183704436 0.08333333333333333 1 -0.12925522774457926 -0.12925522774457926 0.03608922873224531 0.03608922873224531 False False -0.3278391762185723 0.545817179261098 1.069016408891802 -1.571425934780815 283 319.0 424 0 0 True 54657695 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rottlerin rottlerin BRD-K03816923;BRD-K39256324 7 2 HEPG2;PHH -0.2044616436792744 -0.26520309563622707 0.2857446792934622 0.1402384787797927 0.0890575285468782 -0.0217803606674784 -0.06867895497837 0.0 2 -0.2494450501269764 -0.12233859424789739 0.0487649919731276 0.0890575285468782 False False -0.056119838156663396 0.5430847361968827 1.5755143491494383 -1.8445464836523544 284 330.0 478 0 1 True 5281847 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pifithrin-alpha pifithrin-alpha BRD-K66874953 3 2 HEPG2;PHH -0.2520277769201332 -0.28392821819418 0.1945948600769043 0.1788409575819969 0.0620071483509881 -0.0242348837828825 -0.07667281721082941 0.0 1 -0.2520277769201332 -0.2520277769201332 0.0620071483509881 0.0620071483509881 False False -0.0625712923882972 0.5319404828796779 1.3492113080718782 -2.2109876517178613 285 413.0 518 0 1 True 4817 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gefitinib gefitinib BRD-K64052750 4 2 HEPG2;PHH -0.011291920957672948 -0.04672017155422102 0.06642773960317885 0.04352619173005225 -0.0727787110289292 0.025609008642652697 -0.187649623222006 0.0 1 -0.011291920957672948 -0.011291920957672948 -0.0727787110289292 -0.0727787110289292 False False -0.06821580296835031 0.5221901454367933 0.2166607446184323 0.08902859792890397 286 292.0 335 0 1 True 123631 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +clomifene clomifene BRD-K04218075;BRD-K29950728 11 2 HEPG2;PHH 0.2632868703868654 0.1214710709949334 -0.0820094948368413 -0.1051154565066099 -0.2086895789418901 -0.0218995089923578 -0.692612143455162 0.09090909090909091 2 0.2057103353242079 0.3074872261948055 -0.29288050745214733 -0.1051154565066099 False False -0.3682055807199388 0.5190064454366639 -1.0192079342273654 2.392275537903688 287 148.0 292 0 1 True 1548955 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +amperozide amperozide BRD-K52397688 3 2 HEPG2;PHH -0.1872864369716909 -0.2507418354766236 -0.134963429399899 0.3494875011965632 -0.134963429399899 0.0056398053623972 -0.15486181772402713 0.0 1 -0.1872864369716909 -0.1872864369716909 -0.134963429399899 -0.134963429399899 False False -0.07179110349961637 0.5160141650492713 0.3701734256704422 -1.6881525910850712 288 433.0 528 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k03113036 BRD-K03113036 BRD-K03113036 12 3 HEPG2;HUH7;PHH -0.1232784303008682 -0.25302277707184356 -0.045596709208828995 0.20928244385868305 -0.045596709208828995 -0.1868492543534745 -0.32640581289703574 0.08333333333333333 1 -0.1232784303008682 -0.1232784303008682 -0.045596709208828995 -0.045596709208828995 False False -0.35005216080199236 0.5074464308622352 0.4468415534945283 -1.280976359471109 289 391.0 452 0 0 True 54654335 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rolipram rolipram BRD-A34255068 4 2 HEPG2;PHH 0.006134291282958448 -0.1530264925418628 -0.2748973997575896 0.1345582618378103 -0.2748973997575896 -0.3910582364862046 -1.019478059065203 0.25 1 0.006134291282958448 0.006134291282958448 -0.2748973997575896 -0.2748973997575896 False False -0.9007972660188062 0.5002901786034032 -1.0487374495877977 -0.1306128118104115 290 412.0 504 0 1 True 448055 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rotenone rotenone BRD-K08316444 13 3 HEPG2;HUH7;PHH -0.1823041608764065 -0.3028484028246667 0.1956914620740073 0.2806804524734616 0.1753128878772258 0.0630347284946649 -0.2881487562424607 0.0 1 -0.1823041608764065 -0.1823041608764065 0.1753128878772258 0.1753128878772258 False False -0.08103964962656546 0.5000382103026354 1.9468446625276412 -1.8188492327000247 291 278.0 452 0 0 True 6758 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k74228917 BRD-K74228917 BRD-K74228917 12 3 HEPG2;HUH7;PHH -0.10847043142550515 -0.17584507198383406 -0.05099262243935035 0.20069355331361288 -0.0652441840086664 -0.1267719467259234 -0.4920429227197365 0.08333333333333333 1 -0.10847043142550515 -0.10847043142550515 -0.0652441840086664 -0.0652441840086664 False False -0.37279340808579164 0.46816316055130636 0.3547638062927418 -0.9437802650269297 292 380.0 444 0 0 True 1635461 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k75418563 BRD-K75418563 BRD-K75418563 12 3 HEPG2;HUH7;PHH -0.0641338264362679 -0.16637377865198585 0.01376578211784365 0.020791010931134196 -0.12920614198914596 -0.11179411835185 -0.5230747791753698 0.08333333333333333 1 -0.0641338264362679 -0.0641338264362679 -0.12920614198914596 -0.12920614198914596 False False -0.3733315079395349 0.4672336459233235 -0.15311619464466872 -0.6271813301704142 293 396.0 417 0 0 True 54618673 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a99518825 BRD-A99518825 BRD-A99518825 3 2 HEPG2;PHH 0.0194927321539984 -0.05187986170252165 0.2634495688336236 0.0828204872086644 -0.060378217271396 -0.0598534587844614 -0.08086190887519876 0.0 1 0.0194927321539984 0.0194927321539984 -0.060378217271396 -0.060378217271396 False False -0.10028441322206078 0.4667947720269199 0.9548657809953667 0.27215538300298225 294 127.0 255 0 0 True 4207918 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +alpha-linolenic-acid alpha-linolenic-acid BRD-K33396764 13 3 HEPG2;HUH7;PHH -0.0484238339381085 -0.1329251660241021 -0.0613722556403705 0.1636937200091779 -0.0632509624119848 -0.1298964856902048 -0.4575963350870307 0.07692307692307693 1 -0.0484238339381085 -0.0484238339381085 -0.0632509624119848 -0.0632509624119848 False False -0.35869465323372013 0.45620192028105966 0.2182206209804085 -0.42089487169892126 295 340.0 401 0 1 True 5280934 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k60932973 BRD-K60932973 BRD-K60932973 14 3 HEPG2;HUH7;PHH -0.005654249133335201 -0.050125524324054475 -0.03940012864768505 0.0921290516853332 -0.12134613788553644 -0.1629135605494772 -0.3722663214799785 0.07142857142857142 1 -0.005654249133335201 -0.005654249133335201 -0.12134613788553644 -0.12134613788553644 False False -0.34904672128946646 0.4417402427463018 -0.07867939455245415 0.11487085557189765 296 318.0 344 0 0 True 10452020 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +testosterone testosterone BRD-A55393291;BRD-K90553655 4 2 HEPG2;PHH 0.0698187952447269 -0.12482450861069885 0.13384285994938436 -0.14901331719011066 -0.14901331719011066 0.0322142536234524 -0.2942890522646763 0.0 2 -0.1138178615106476 0.2534554520001014 -0.1825500018894672 -0.1154766324907541 True False -0.11493027250888574 0.44149548909312764 -0.35245616020806586 0.36979456122302545 297 272.0 448 0 1 True 5408;5995;6010 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k55851396 BRD-K55851396 BRD-K55851396 12 3 HEPG2;HUH7;PHH -0.10701178345415324 -0.3446189258506315 -0.0816063056034701 0.24794944189488885 -0.08229540647672755 -0.1233093330030521 -0.5395817732704538 0.08333333333333333 1 -0.10701178345415324 -0.10701178345415324 -0.08229540647672755 -0.08229540647672755 False False -0.39310021963827896 0.43308513877816734 0.36088955695857483 -1.4621222519142183 298 367.0 467 0 0 True 54654475 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +alaproclate alaproclate BRD-A14966924 3 2 HEPG2;PHH -0.145738887704081 -0.1575605926983472 0.2610785812139511 0.0434625018388032 0.0434625018388032 0.0065316538222962 -0.2644569897092878 0.0 1 -0.145738887704081 -0.145738887704081 0.0434625018388032 0.0434625018388032 False False -0.1256968410323477 0.42289729980517254 1.0957995827437366 -1.1278318521728388 299 333.0 464 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dioxybenzone dioxybenzone BRD-K22193694 3 2 HEPG2;PHH -0.174816312889258 -0.2578021550758017 0.7297960817813873 0.2682884223759174 -0.1780864766665867 0.007229288548438 -0.2777937254295611 0.0 1 -0.174816312889258 -0.174816312889258 -0.1780864766665867 -0.1780864766665867 False False -0.13166757416634256 0.41258344495235494 2.6023281265177083 -1.6295151208143612 300 61.0 333 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +m-3m3fbs m-3M3FBS BRD-K09635314 3 2 HEPG2;PHH -0.2511551951368649 -0.2735219916535748 0.0691046799932207 0.1827043704688549 -0.0104309916496276 0.0560236385180836 -0.3957255777001144 0.0 1 -0.2511551951368649 -0.2511551951368649 -0.0104309916496276 -0.0104309916496276 False False -0.1418391503319736 0.3950130465033948 0.8002642440422878 -2.1727976559330693 301 459.0 525 0 1 True 761523 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +aristolochic-acid aristolochic-acid BRD-K17110974 3 2 HEPG2;PHH 0.136090696685844 0.0692856709162394 -0.0437554589339665 0.0878971852362155 -0.0437554589339665 0.0381171891081427 -0.369231369656821 0.0 1 0.136090696685844 0.136090696685844 -0.0437554589339665 -0.0437554589339665 False False -0.1464984957202678 0.38696448513487514 0.0941704725905993 1.4057716603197465 302 161.0 223 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rk-682 RK-682 BRD-A77349281 3 2 HEPG2;PHH 0.2933529590566953 -0.05303879371947712 -0.1810071468353271 0.0822125114500522 -0.1810071468353271 -0.0817600141264616 -0.13229813603388646 0.0 1 0.2933529590566953 0.2933529590566953 -0.1810071468353271 -0.1810071468353271 False False -0.1479090821434048 0.3845278356817692 -0.6843129641190194 2.041165491550435 303 98.0 202 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +rizatriptan rizatriptan BRD-K75699339 3 2 HEPG2;PHH -0.2803861097329193 -0.32499131335256 0.1935357217277799 0.0260437615215778 0.0260437615215778 -0.052313341788711 -0.1947991940569842 0.0 1 -0.2803861097329193 -0.2803861097329193 0.0260437615215778 0.0260437615215778 False False -0.1497129388172031 0.38141185051021387 0.7972359755355907 -2.5229556425897 304 500.0 541 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nsc-693868 NSC-693868 BRD-K31268420;BRD-K87932577 4 2 HEPG2;PHH 0.20663026244276095 0.06746399081829518 0.003062563815287151 -0.10045219119638205 -0.1590473591350019 0.007257161957640507 -0.3214292058070737 0.0 2 0.0918399033447107 0.34861606318089694 -0.22428197506815195 -0.1590473591350019 False False -0.15345744094589633 0.3749435909875229 -0.6239268396652915 1.8566613579771145 305 162.0 275 0 1 True 438981 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +yc-1 YC-1 BRD-K60476892 14 3 HEPG2;HUH7;PHH -0.0957693381545444 -0.24680343642830843 0.1187843305191823 0.09377273265272375 -0.0004089358927948025 -0.021219268138150803 -0.26784985892785085 0.0 1 -0.0957693381545444 -0.0957693381545444 -0.0004089358927948025 -0.0004089358927948025 False False -0.15514419760207623 0.3720298845910986 0.7085608990160073 -1.083467434619671 306 328.0 404 0 1 True 5712 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +asiatic-acid asiatic-acid BRD-A72758037 3 2 HEPG2;PHH -0.230207969331079 -0.3209339696913957 0.1509294041565486 -0.0024962807074189 -0.0024962807074189 -0.061796532914279 -0.20149218115127746 0.0 1 -0.230207969331079 -0.230207969331079 -0.0024962807074189 -0.0024962807074189 False False -0.16254262348991771 0.35924983077960443 0.5115189357272844 -2.185476099399799 307 493.0 524 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dorsomorphin dorsomorphin BRD-K54233340 4 2 HEPG2;PHH -0.33469823646980024 -0.443657503152887 0.1876058429479599 0.2798100132495165 0.1876058429479599 -0.08822478858443594 -0.15204991605354562 0.0 1 -0.33469823646980024 -0.33469823646980024 0.1876058429479599 0.1876058429479599 False False -0.16424974661120875 0.35630094331574547 1.9515225959159888 -3.245594159248246 308 430.0 545 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tamoxifen tamoxifen BRD-K43744935;BRD-K93754473 17 2 HEPG2;PHH 0.0022784111400445 -0.1043000088797675 -0.0584906062909535 0.036412273067981 -0.1460595764219761 -0.0878351049586421 -0.5483564371132247 0.058823529411764705 2 -0.11200277590089369 0.083022820452849 -0.1460595764219761 0.049557576089033106 True True -0.36201332351525445 0.3479314908320114 -0.3655501876763234 -0.0031953434091117044 309 353.0 355 0 1 True 2733526;3032583 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +clemastine clemastine BRD-K30240666 3 2 HEPG2;PHH -0.0059121764368481 -0.0755431158468127 -0.0391561612486839 0.1792141329497099 -0.0391561612486839 -0.0499688199617796 -0.238270197995007 0.0 1 -0.0059121764368481 -0.0059121764368481 -0.0391561612486839 -0.0391561612486839 False False -0.16910391895928312 0.34791583751633376 0.3926839521328751 0.03371638031141384 310 270.0 345 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fipronil fipronil BRD-A50675702 3 2 HEPG2;PHH -0.4082249907983674 -0.4333786596026685 0.5068221597799233 0.1840000115334987 0.1840000115334987 -0.0906320181896999 -0.1619869862564854 0.0 1 -0.4082249907983674 -0.4082249907983674 0.1840000115334987 0.1840000115334987 False False -0.1716255113179426 0.34356003446810957 2.6101797863600633 -3.6893723065927997 311 410.0 556 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +inca-6 INCA-6 BRD-K33308633 3 2 HEPG2;PHH 0.1003925369845496 -0.03246846091416146 -0.1387186614530427 0.1677214317023754 -0.1387186614530427 -0.0047627560469129 -0.3516596760009489 0.0 1 0.1003925369845496 0.1003925369845496 -0.1387186614530427 -0.1387186614530427 False False -0.18059259404738734 0.32807028008633543 -0.19405869600539366 0.8565038471114438 312 201.0 338 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sa-1973509 SA-1973509 BRD-K66555347 12 3 HEPG2;HUH7;PHH -0.17174651416846445 -0.2946039661765098 -0.019548082990305735 0.15820953063666815 -0.06150760089180295 -0.20958285976482166 -0.4987252373654868 0.08333333333333333 1 -0.17174651416846445 -0.17174651416846445 -0.06150760089180295 -0.06150760089180295 False False -0.45894547844756506 0.31934392361003805 0.331321119457916 -1.72473030960403 313 454.0 489 0 0 True 54657693 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tetramisole tetramisole BRD-A46393198 3 2 HEPG2;PHH -0.0766611066129472 -0.155583141112907 0.1424219057496105 0.1138913428876549 0.1138913428876549 -0.1063485512942341 -0.1630518059846797 0.0 1 -0.0766611066129472 -0.0766611066129472 0.1138913428876549 0.1138913428876549 False False -0.18787445428657396 0.3154915819800906 1.1318179151906431 -0.6745234436140229 314 287.0 367 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +epirubicin epirubicin BRD-K04548931 3 2 HEPG2;PHH -0.7277194501625167 -0.7483986201469734 0.3835000076464244 0.2421302385628223 0.2421302385628223 0.005291130615487 -0.3872436089958582 0.0 1 -0.7277194501625167 -0.7277194501625167 0.2421302385628223 0.2421302385628223 False False -0.1883306738824421 0.31470350745269215 2.56401628329486 -6.742505484143387 315 568.0 574 0 1 True 32875 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sb-203580 SB-203580 BRD-A37704979;BRD-K99291625 4 2 HEPG2;PHH -0.0221966569208436 -0.131619231775403 -0.13203987745302065 0.061299135908484445 -0.14730363698410137 -0.04817046017371229 -0.2941720702995856 0.0 2 -0.0221966569208436 0.0281195179041889 -0.2917291953095368 0.02620349658120955 True True -0.19525649532350509 0.30273983138870053 -0.5142116171197482 -0.2470485151477108 316 403.0 436 0 1 True 176155;6610350 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fexofenadine fexofenadine BRD-A73368467 3 2 HEPG2;PHH -0.0663916685928901 -0.17660974845704108 -0.2643785625696182 0.2579125054180622 -0.2643785625696182 -0.0353995133708748 -0.3316364419528298 0.0 1 -0.0663916685928901 -0.0663916685928901 -0.2643785625696182 -0.2643785625696182 False False -0.2012177343472897 0.2924423766784563 -0.6216047514514711 -0.6738053771387297 317 411.0 532 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cortisone-acetate cortisone-acetate BRD-A54487287 3 2 HEPG2;PHH 0.0765768285426828 -0.044874590511123344 -0.0530256692852292 -0.0650312546640634 -0.0650312546640634 -0.106419899131334 -0.19740791095509413 0.0 1 0.0765768285426828 0.0765768285426828 -0.0650312546640634 -0.0650312546640634 False False -0.20512385460888105 0.28569493771048016 -0.4451652575106132 0.6635542435223599 318 322.0 374 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +perphenazine perphenazine BRD-K10995081 3 2 HEPG2;PHH 0.1176111068990495 0.08408749289810655 -0.0979566148349217 -0.0520946932956576 -0.1065312423743307 -0.1063228063137521 -0.20135133547176198 0.0 1 0.1176111068990495 0.1176111068990495 -0.1065312423743307 -0.1065312423743307 False False -0.2069984740496331 0.2824567168115919 -0.6469947564596851 1.3324452460456042 319 294.0 366 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +obaa OBAA BRD-K48029790;BRD-K85318537 4 2 HEPG2;PHH 0.027818999977575396 -0.091347279984297 -0.09198350512555664 0.1889821582008153 -0.09198350512555664 -0.061656931173130244 -0.29200674572013435 0.0 2 -0.1732241874043312 0.07640692115657854 -0.28405298851430416 0.11006328357117519 True True -0.2076603040331974 0.2813134705410693 0.12879344147620517 0.20262831988985094 320 255.0 362 0 1 True 5353842 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +thiothixene thiothixene BRD-K55070890;BRD-K97309399 3 2 HEPG2;PHH -0.0430271708303027 -0.1350330289246307 0.4730785723243441 -0.0252624968998134 -0.0252624968998134 -0.1203981938934515 -0.17617746468426448 0.0 2 -0.04774444063918459 -0.0430271708303027 -0.13475311989895994 0.0800431929528713 False True -0.20848692623558374 0.2798855619036882 1.3482883114153155 -0.3925551447606988 321 139.0 436 1 1 True 6444849;941650 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +estrone estrone BRD-K81839095 8 2 HEPG2;PHH -0.04472111682924955 -0.0837815266050812 -0.0323639991027968 -0.0647606514394283 -0.0647606514394283 -0.07365537985479315 -0.2725330419572336 0.0 1 -0.04472111682924955 -0.04472111682924955 -0.0647606514394283 -0.0647606514394283 False False -0.20992190083340995 0.27740678427499227 -0.3818949483890026 -0.24324782690496055 322 435.0 472 0 1 True 5870;7059423 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +crizotinib crizotinib BRD-K78431006 8 2 HEPG2;PHH -0.29006733579768074 -0.6801875618596872 0.5029936209321022 0.2570795742794871 0.1702013558575085 -0.0007516391250113053 -0.4331184445569912 0.0 1 -0.29006733579768074 -0.29006733579768074 0.1702013558575085 0.1702013558575085 False False -0.21731086140350692 0.2646430808699159 2.781903849208038 -3.6963768296423325 323 239.0 501 0 1 True 11626560 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +o-3m3fbs O-3M3FBS BRD-K46384212 3 2 HEPG2;PHH 0.6550976476735539 0.36746548923353356 -0.2308428564241954 -0.2339062467217445 -0.3578616098633834 0.0579987074551542 -0.5508911324210376 0.0 1 0.6550976476735539 0.6550976476735539 -0.3578616098633834 -0.3578616098633834 False False -0.2174468587553646 0.2644081588065864 -2.2308455379677987 5.697641438769465 324 33.0 203 4 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +indirubin-3-monoxime indirubin-3-monoxime BRD-K19136521 3 2 HEPG2;PHH -0.219887163490057 -0.2437671867923604 0.6673724949359894 -0.0284934863448143 -0.0284934863448143 0.0568121112883091 -0.54918282199651 0.0 1 -0.219887163490057 -0.219887163490057 -0.0284934863448143 -0.0284934863448143 False False -0.21777929970994592 0.2638338997205184 1.9112126036265988 -1.8773587291787874 325 220.0 528 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +carbamazepine carbamazepine BRD-K71799949 4 2 HEPG2;PHH -0.19873223143319285 -0.36121783162363696 -0.05263794692499296 -0.016537861432880198 -0.14481207269376944 -0.5787810583613694 -0.9292937334560389 0.25 1 -0.19873223143319285 -0.19873223143319285 -0.14481207269376944 -0.14481207269376944 False False -1.043427925089389 0.253909728799 -0.5031583234393822 -2.107715118587517 326 512.0 526 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tyrphostin-ag-1478 tyrphostin-AG-1478 BRD-K68336408 3 2 HEPG2;PHH 0.1765397468374835 0.06255852679411569 -0.1067892738751002 0.0161167345941066 -0.1067892738751002 0.0449125554471735 -0.5523507643402332 0.0 1 0.1765397468374835 0.1765397468374835 -0.1067892738751002 -0.1067892738751002 False False -0.23126282672294313 0.24054243158835406 -0.47013951392498826 1.6465521799868665 327 191.0 289 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +icilin icilin BRD-K48869804 3 2 HEPG2;PHH 0.0877755267752541 0.001648538487239004 0.2681253073470933 -0.0309604778885841 -0.1520286556333303 -0.1612725211898722 -0.164204650011564 0.0 1 0.0877755267752541 0.0877755267752541 -0.1520286556333303 -0.1520286556333303 False False -0.2433748461956542 0.2196201079787472 0.39419628186642325 0.8815262853175969 328 133.0 304 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +enrofloxacin enrofloxacin BRD-K76534306 3 2 HEPG2;PHH 0.0465186795012818 0.03323433848304875 0.1518928621496473 -0.1363520491868257 -0.1363520491868257 -0.1232535484291258 -0.24975256539053386 0.0 1 0.0465186795012818 0.0465186795012818 -0.1363520491868257 -0.1363520491868257 False False -0.24812983112439274 0.211406338700881 -0.22824865025604696 0.7132541684424021 329 281.0 456 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k68866125 BRD-K68866125 BRD-K68866125 12 3 HEPG2;HUH7;PHH -0.34158457339637804 -0.5338889485639002 0.20721999715481482 0.2649506460875273 0.09766351591263495 -0.28392582172380076 -0.4792116813709043 0.08333333333333333 1 -0.34158457339637804 -0.34158457339637804 0.09766351591263495 0.09766351591263495 False False -0.523531662409253 0.2077776365345787 1.7356129383001002 -3.572336341062149 330 446.0 547 0 0 True 3290072 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +oxaprozin oxaprozin BRD-K25394294 15 3 HEPG2;HUH7;PHH -0.0365935679939058 -0.21211544124202591 -0.0828333316104752 -0.0179793387651443 -0.1024216966969626 -0.1432096108808995 -1.0935414071852665 0.13333333333333333 1 -0.0365935679939058 -0.0365935679939058 -0.1024216966969626 -0.1024216966969626 False False -0.6899803144735328 0.20351448556497442 -0.48927910166022154 -0.5919612394083369 331 427.0 441 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +thiotepa thiotepa BRD-K09631521 3 2 HEPG2;PHH 0.1770916614267561 0.10533749974436224 -0.2907357066869735 -0.2634223904460668 -0.4316499889828264 -0.8315761698823836 -1.0346699949087843 0.3333333333333333 1 0.1770916614267561 0.1770916614267561 -0.4316499889828264 -0.4316499889828264 False False -1.3489111673367757 0.19831834475214372 -2.6869308445896136 1.783901450211216 332 449.0 527 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k57064803 BRD-K57064803 BRD-K57064803 18 3 HEPG2;HUH7;PHH -0.011229003055228101 -0.2425960980148779 0.00476765419755665 0.11646127840504045 -0.083442308407809 -0.18664163168859735 -0.8689233124670055 0.1111111111111111 1 -0.011229003055228101 -0.011229003055228101 -0.083442308407809 -0.083442308407809 False False -0.6211032879221001 0.19659920760070437 0.2230842287733763 -0.5231002480624395 333 289.0 308 0 0 True 54646218 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ichthynone ichthynone BRD-K28167849 12 3 HEPG2;HUH7;PHH -0.3897085276742776 -0.6417204727315241 0.23067659884691233 0.4108785865828395 0.18296750102724346 -0.1334161685838822 -0.8038933323696256 0.08333333333333333 1 -0.3897085276742776 -0.3897085276742776 0.18296750102724346 0.18296750102724346 False False -0.535362834768695 0.1873404487193684 2.4602522127073225 -4.2210384665280145 334 421.0 553 0 0 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +diethylcarbamazine diethylcarbamazine BRD-K45542189 3 2 HEPG2;PHH -0.0252540904200739 -0.15946701075881717 -0.1792047598532267 0.3509316965937614 -0.1792047598532267 -0.066199563532358 -0.40252749694304324 0.0 1 -0.0252540904200739 -0.0252540904200739 -0.1792047598532267 -0.1792047598532267 False False -0.2674633120038796 0.178009650033716 0.1290346943660447 -0.353923144471482 335 273.0 475 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +diloxanide diloxanide BRD-K10974103 3 2 HEPG2;PHH -0.0766750025666422 -0.251641773023746 0.053699995790209 0.0452749924734234 0.0055855344980955 -0.1692692647274169 -0.20272642425039689 0.0 1 -0.0766750025666422 -0.0766750025666422 0.0055855344980955 0.0055855344980955 False False -0.2706324768526154 0.17253522913414335 0.3843396101846928 -0.9750044616811601 336 371.0 404 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +zd-7114 ZD-7114 BRD-K45296539 3 2 HEPG2;PHH -0.0151646346267726 -0.22791704421655995 0.143178607736315 0.0528950728476047 -0.0703746506146022 -0.1294663994321747 -0.28621890423597673 0.0 1 -0.0151646346267726 -0.0151646346267726 -0.0703746506146022 -0.0703746506146022 False False -0.27257585155016306 0.1691782402844785 0.48027048697199887 -0.5026708811856536 337 247.0 328 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +le-135 LE-135 BRD-K06593056 3 2 HEPG2;PHH -0.1102972196208106 -0.2199624929991033 -0.1080571434327534 0.3617499954998493 -0.1080571434327534 -0.1753721729822693 -0.22405287427901627 0.0 1 -0.1102972196208106 -0.1102972196208106 -0.1080571434327534 -0.1080571434327534 False False -0.2873986101217774 0.14357338121691185 0.5561119978967076 -1.0935670452518333 338 325.0 482 0 1 True 10410894 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +raloxifene raloxifene BRD-K63828191 27 2 HEPG2;PHH 0.0600563643707169 -0.010583139955997401 -0.2004257866314479 -0.0694825937971472 -0.257151348516345 -0.35648111112061 -0.6010435163671712 0.1111111111111111 1 0.0600563643707169 0.0600563643707169 -0.257151348516345 -0.257151348516345 False False -0.6570028693041956 0.1345862079669201 -1.39068576197864 0.663856059094122 339 425.0 476 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k81164606 BRD-K81164606 BRD-K81164606 12 3 HEPG2;HUH7;PHH -0.0930417585704061 -0.3136040108381874 0.13970455793397762 0.2903335657902062 0.0414541235991887 -0.1624134833820992 -0.2750590279114447 0.0 1 -0.0930417585704061 -0.0930417585704061 0.0414541235991887 0.0414541235991887 False False -0.2999429973378216 0.12190418481166987 1.4658399054359064 -1.2747087747228207 340 196.0 350 0 0 True 54649959 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k46088987 BRD-K46088987 BRD-K46088987 12 3 HEPG2;HUH7;PHH -0.19721877088563305 -0.300435929869612 0.0782255493104458 0.3232711339369416 0.0254531694310052 -0.0632812732549769 -0.47367423574351475 0.0 1 -0.19721877088563305 -0.19721877088563305 0.0254531694310052 0.0254531694310052 False False -0.3001183911267343 0.12160120927410455 1.3395743549753703 -1.907843875900137 341 338.0 473 0 0 True 54650090 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k02269790 BRD-K02269790 BRD-K02269790 12 3 HEPG2;HUH7;PHH -0.06392157346838045 -0.19235395971271727 -0.17587682924100326 0.0300202658399939 -0.25554927864245003 -0.4825097844669861 -0.7300660371251907 0.16666666666666666 1 -0.06392157346838045 -0.06392157346838045 -0.25554927864245003 -0.25554927864245003 False False -0.8475428030295815 0.12018112845056439 -1.0157283919955293 -0.7070517462610336 342 475.0 492 0 0 True 4671491 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k94818765 BRD-K94818765 BRD-K94818765 12 3 HEPG2;HUH7;PHH -0.01646298718535235 -0.20224810324402318 0.021922266909054352 -0.058419480454176595 -0.17467391703810004 -0.32077851418464903 -0.5219487398253044 0.08333333333333333 1 -0.01646298718535235 -0.01646298718535235 -0.17467391703810004 -0.17467391703810004 False False -0.5817528840973012 0.10720619641689277 -0.481868035718214 -0.4308038367386622 343 381.0 444 0 0 True 695345 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pirenperone pirenperone BRD-K25224017 3 2 HEPG2;PHH -0.0160222225305106 -0.12488148516664895 0.1105476181421961 0.100358348339796 0.100358348339796 -0.1282877645617912 -0.3625561517131115 0.0 1 -0.0160222225305106 -0.0160222225305106 0.100358348339796 0.100358348339796 False False -0.30956584041834695 0.10528166885313557 0.9614456536156206 -0.1860127840227211 344 240.0 284 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +glimepiride glimepiride BRD-K34776109;BRD-K42693031 4 2 HEPG2;PHH -0.01839305584629375 -0.1248250051091114 0.1338642867548125 0.06568124867044389 -0.09210937307216224 -0.19826040282431576 -0.22782658307724407 0.0 2 -0.1857944474452071 0.0456708330247137 -0.1372700840168233 -0.07912857072161775 True False -0.3121736943629378 0.10077685739058377 0.4350398046422581 -0.20118202054956325 345 250.0 311 0 1 True 3476 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +estriol estriol BRD-A84205515;BRD-K17016787 16 2 HEPG2;PHH 0.060239401180297095 -0.19632984552946353 -0.1565704060984509 -0.0154309328645467 -0.16152681540032582 -0.2400823109487574 -0.5639379251977458 0.0625 2 0.052044738549739095 0.1720681748508165 -0.16152681540032582 -0.14534102220620423 False False -0.5220512735476303 0.09230963718893787 -0.8533257043164024 0.08418044766646765 346 369.0 417 0 1 True 3269;40488277;5756;6710621 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +simvastatin simvastatin BRD-K22134346 16 3 HEPG2;HUH7;PHH 0.12819521646532744 0.05198837827063263 -0.051055009875978705 -0.12236953061074014 -0.2231877595186233 -0.25537398890666074 -0.5442312158965728 0.0625 1 0.12819521646532744 0.12819521646532744 -0.2231877595186233 -0.2231877595186233 False False -0.5274895968549471 0.08291546800140409 -1.0153446551661252 1.3005745655529675 347 297.0 376 0 1 True 73707467 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nilotinib nilotinib BRD-K81528515 8 2 HEPG2;PHH -0.1217968476315339 -0.2451305698810352 -0.01192579418420785 -0.04488710593432185 -0.04800263206873615 -0.050902363356380195 -0.5445196370498114 0.0 1 -0.1217968476315339 -0.1217968476315339 -0.04800263206873615 -0.04800263206873615 False False -0.3231621818812859 0.08179532484293625 -0.21850453065464823 -1.246706191189337 348 474.0 501 0 1 True 644241 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +bithionol bithionol BRD-K39120595 3 2 HEPG2;PHH -0.2492372607812285 -0.4023908444473313 0.1148928595440728 -0.0224812533706426 -0.0310500008719308 -0.1529999935467328 -0.34803024931470794 0.0 1 -0.2492372607812285 -0.2492372607812285 -0.0310500008719308 -0.0310500008719308 False False -0.3270151182040868 0.07513975590379511 0.27098328048414455 -2.5633773143763094 349 520.0 538 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k19914944 BRD-K19914944 BRD-K19914944 12 3 HEPG2;HUH7;PHH 0.08079707374175385 -0.08038853191667125 -0.14146389280046728 0.1563276974484324 -0.18086258827575613 -0.2585655890094737 -0.6842929457207136 0.08333333333333333 1 0.08079707374175385 0.08079707374175385 -0.18086258827575613 -0.18086258827575613 False False -0.6007120618698305 0.07445607959098777 -0.34415620469890873 0.5798130097000246 350 243.0 359 0 0 True 54650153 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +estropipate estropipate BRD-A22143024 3 2 HEPG2;PHH 0.392970222617603 0.2171990014871375 -0.1775113684790475 -0.1215534284710884 -0.1775113684790475 -0.0228292285760361 -0.6124076376676499 0.0 1 0.392970222617603 0.392970222617603 -0.1775113684790475 -0.1775113684790475 False False -0.32903304740986106 0.07165398146629448 -1.274085187141577 3.5310429734434505 351 99.0 286 1 1 True 6093179 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a65142661 BRD-A65142661 BRD-A65142661 12 3 HEPG2;HUH7;PHH -0.022405346441600048 -0.1984635628759861 -0.1535549914198262 0.02142151258885855 -0.1535549914198262 -0.30679543203275117 -0.5949279315333578 0.08333333333333333 1 -0.022405346441600048 -0.022405346441600048 -0.1535549914198262 -0.1535549914198262 False False -0.60425939779943 0.06832840530526813 -0.7137424669818881 -0.4574324843540132 352 443.0 456 0 0 True 2850171 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +practolol practolol BRD-A41304429 3 2 HEPG2;PHH 0.4478504505629341 0.19432661335708368 -0.1404714179890496 -0.3019874850288033 -0.3019874850288033 -0.1398745815136602 -0.3843841028384982 0.0 1 0.4478504505629341 0.4478504505629341 -0.3019874850288033 -0.3019874850288033 False False -0.3320666329329093 0.06641376053091426 -2.0212497972751007 3.8147443667468375 353 111.0 335 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +doxepin doxepin BRD-K36616567;BRD-K37694030;BRD-K54462405 8 2 HEPG2;PHH 0.017751499596569298 -0.19133215545055762 -0.206677817340408 0.07039185054600235 -0.24209285727036844 -0.3486056741334439 -0.7931035098191055 0.125 3 -0.165344342485898 0.4496143830215765 -0.3565945412431444 0.2288571503013372 True True -0.7451574290429966 0.060991351143988015 -0.9526873931675383 -0.17520537452999912 354 402.0 468 0 1 True True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k65997856 BRD-K65997856 BRD-K65997856 12 3 HEPG2;HUH7;PHH 0.089412374732395 -0.1605802011779613 -0.12418795270579194 -0.04239490814507005 -0.16363679298332756 -0.2473950492705972 -0.7223526816149907 0.08333333333333333 1 0.089412374732395 0.089412374732395 -0.16363679298332756 -0.16363679298332756 False False -0.6085713900780925 0.06087986230551784 -0.8425254647058612 0.38480538991436725 355 334.0 394 0 0 True 54618712 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +desoximetasone desoximetasone BRD-A49447682;BRD-K30697463 4 2 HEPG2;PHH -0.01306416549616385 -0.033435420495354425 0.028657141008547403 0.10130099952220914 -0.1302347795239516 -0.1301662606142816 -0.4132719840041346 0.0 2 -0.024250001543098 0.174958675685856 -0.2422766983509063 -0.0181928606969969 True False -0.3368022526163489 0.05823344281162891 0.1294584735605285 0.1191008586324628 356 282.0 306 0 1 True 5311067 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fluticasone fluticasone BRD-A59943784;BRD-K14791739 3 2 HEPG2;PHH -0.17807972845104 -0.2715162537578079 0.0990395758833204 0.0394939258694648 -0.0671679116785526 -0.1088129775746474 -0.4589524888950918 0.0 2 -0.3649527790645758 0.005393400581346644 -0.2631645628384181 -0.013836992904543901 True False -0.3382892220221933 0.055664849260672694 0.3164562828233798 -1.6935246918021054 357 458.0 495 0 1 True 25320895;44483336;73707412 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +prednicarbate prednicarbate BRD-K46137903 3 2 HEPG2;PHH -0.0536851191168857 -0.13770506052403808 -0.0215571309838976 -0.0929375011473894 -0.0929375011473894 -0.1117535656879818 -0.4566756597468777 0.0 1 -0.0536851191168857 -0.0536851191168857 -0.0929375011473894 -0.0929375011473894 False False -0.34009139556142065 0.052551771538717436 -0.5059158893528678 -0.4698974737759014 358 453.0 492 0 1 True 73707478 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mycophenolic-acid mycophenolic-acid BRD-K31542390;BRD-K63750851 27 3 HEPG2;HUH7;PHH -0.1684679202735424 -0.26193618660585744 0.0535116962024143 -0.021758034825325 -0.0705508030951023 -0.2509037386034689 -0.43887231651220526 0.037037037037037035 2 -0.17338728842635945 -0.0653916622201601 -0.12979539856314654 -0.0504963972738811 False False -0.4703398968595715 0.03738290609819567 -0.01142212254682183 -1.6013512287214196 359 492.0 505 0 1 True 446541 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sa-1973507 SA-1973507 BRD-K35468722 12 3 HEPG2;HUH7;PHH -0.1462058081912497 -0.2668831214670919 0.07015457802585195 0.25084213563241065 0.0607014264512275 -0.0669065671677272 -0.5700249518508033 0.0 1 -0.1462058081912497 -0.1462058081912497 0.0607014264512275 0.0607014264512275 False False -0.3519190430931288 0.032120672517096036 1.1891015158899905 -1.4727235714781024 360 326.0 439 0 0 True 54657689 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +necrostatin-1 necrostatin-1 BRD-A36318220 3 2 HEPG2;PHH 0.070933621790674 -0.04812346233261955 -0.0328548827341624 -0.0946062542498111 -0.0946062542498111 -0.226295056102413 -0.2604512001742564 0.0 1 0.070933621790674 0.070933621790674 -0.0946062542498111 -0.0946062542498111 False False -0.3565206561895412 0.024171838010492063 -0.5489494568143224 0.6168673095579583 361 332.0 398 0 1 True 2828334 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +flecainide flecainide BRD-A09472452 3 2 HEPG2;PHH 0.13911248350309 0.0556145748123527 -0.127536831157548 -0.1830061143264174 -0.1830061143264174 -0.112144489085213 -0.5037993957207257 0.0 1 0.13911248350309 0.13911248350309 -0.1830061143264174 -0.1830061143264174 False False -0.3640441869455759 0.0111756778309911 -1.32245834224448 1.3825792352488804 362 361.0 456 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +caffeine caffeine BRD-K02404261 3 2 HEPG2;PHH -0.0639353973997963 -0.06404687050316066 0.3231641022222383 -0.0574231026694178 -0.0574231026694178 -0.0171995516275129 -0.6986808298628717 0.0 1 -0.0639353973997963 -0.0639353973997963 -0.0574231026694178 -0.0574231026694178 False False -0.36653996655894877 0.006864463764097017 0.7216815179835765 -0.30590394558641015 363 265.0 477 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +orantinib orantinib BRD-K55966568;BRD-K91696562 3 2 HEPG2;PHH -0.0911589045491483 -0.11987927514645785 0.085425215108054 -0.2232073114719241 -0.2232073114719241 -0.1418050802534534 -0.4549518202150624 0.0 2 -0.0911589045491483 0.16065913594017422 -0.2838112264871597 -0.1205831662518903 True False -0.3692809903609846 0.002129614457006837 -0.9088400291601604 -0.6567125202880418 364 488.0 550 0 1 True 5329099;5995546 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +benazepril benazepril BRD-A15131297 3 2 HEPG2;PHH -0.1537992892165978 -0.2440799584405289 0.1453476250171661 -0.0993996523320674 -0.2516623642295599 -0.1360367726948526 -0.46895412052611984 0.0 1 -0.1537992892165978 -0.1537992892165978 -0.2516623642295599 -0.2516623642295599 False False -0.3705138329579125 0.0 -0.43237534551545453 -1.4505652030706448 365 475.0 530 0 1 True 5362123 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +bucladesine bucladesine BRD-A04706586;BRD-A94624445 15 3 HEPG2;HUH7;PHH -0.0430124319261974 -0.14614591043856406 -0.0274266472884586 -0.0814933949150145 -0.2788408281547682 -0.3303688430774306 -0.9550004347212732 0.13333333333333333 2 -0.0430124319261974 0.03931291551432675 -0.5961303842653121 -0.2000921741127967 True False -0.8078690604380672 -0.00012674028987791353 -0.9648982461131201 -0.42721154358693764 366 441.0 478 0 1 True 23666343;73707507 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +labetalol labetalol BRD-A07440155 3 2 HEPG2;PHH 0.1698171562618679 0.12355857321785552 -0.2655571401119232 0.2959750005975365 -0.2655571401119232 -0.1088174009281728 -0.527188582752373 0.0 1 0.1698171562618679 0.1698171562618679 -0.2655571401119232 -0.2655571401119232 False False -0.37241169230435933 -0.003278365552609985 -0.5143541412319912 1.7937955316144687 367 134.0 388 1 1 True 134044 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cgs-15943 CGS-15943 BRD-K49049886 12 3 HEPG2;HUH7;PHH -0.1140665030106902 -0.18741741383241278 0.009176014789513201 0.08783705998212095 -0.00986035593918385 -0.09243933293998 -0.5636866458189038 0.0 1 -0.1140665030106902 -0.1140665030106902 -0.00986035593918385 -0.00986035593918385 False False -0.3742826558494319 -0.0065102712509107815 0.33895489518949856 -1.016190957738594 368 401.0 449 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dextromethorphan dextromethorphan BRD-K24053527;BRD-K33211335 4 2 HEPG2;PHH 0.12829345030089215 -0.04972553108301435 -0.2728773036173411 0.1465659365057945 -0.2728773036173411 -0.21156973093156772 -0.32711023167662673 0.0 2 0.1017198128004868 0.3497614786028862 -0.3235259226390293 -0.2222286845956529 False False -0.3751248467698811 -0.007965073319088729 -1.0016322430161613 0.9831343591450739 369 268.0 427 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pinacidil pinacidil BRD-A22897758;BRD-A43882281;BRD-A58207013 4 2 HEPG2;PHH -0.0221861154099719 -0.0769583863180337 -0.056475429662636356 -0.053592702373862204 -0.14962467697582071 -0.14519347199460575 -0.46627622448454886 0.0 3 -0.1523585371259186 0.4807629568709267 -0.2320889468703951 -0.0671604070812463 True False -0.3783315842368802 -0.013504397225128322 -0.6377211350116305 -0.07604686724850408 370 427.0 445 0 1 True 4826 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k47533918 BRD-K47533918 BRD-K47533918 12 3 HEPG2;HUH7;PHH -0.23412367680834395 -0.4393684573781987 -0.03059242665767665 0.23792939772829408 -0.03059242665767665 -0.21568420782892228 -0.332309787621766 0.0 1 -0.23412367680834395 -0.23412367680834395 -0.03059242665767665 -0.03059242665767665 False False -0.3818391016398053 -0.01956328891826566 0.6157284418157557 -2.5811856116267453 371 474.0 520 0 0 True 54654288 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +iopanoic-acid iopanoic-acid BRD-A42628519 3 2 HEPG2;PHH -0.1780905484014915 -0.2515313832554966 0.1787143009049552 0.2365284785628318 0.1787143009049552 -0.1107994378618304 -0.5513828592818408 0.0 1 -0.1780905484014915 -0.1780905484014915 0.1787143009049552 0.1787143009049552 False False -0.3864908675027508 -0.027598757401448647 1.7727992046511492 -1.6310987640272503 372 302.0 456 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ici-63197 ICI-63197 BRD-K52219182 3 2 HEPG2;PHH -0.1654666606336832 -0.1861640005889866 0.0516571572848728 -0.0886720977723598 -0.1400729502950395 -0.2075150721366443 -0.3694291810785967 0.0 1 -0.1654666606336832 -0.1654666606336832 -0.1400729502950395 -0.1400729502950395 False False -0.3922296626759426 -0.03751196221533537 -0.39488659125996034 -1.3449727308751074 373 507.0 531 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dropropizine dropropizine BRD-A29349577 12 3 HEPG2;HUH7;PHH 0.21008948190137738 0.0969993743217653 -0.12046686400260234 -0.0984533168375492 -0.20471744984388346 -0.20333984362641494 -0.377868539257352 0.0 1 0.21008948190137738 0.21008948190137738 -0.20471744984388346 -0.20471744984388346 False False -0.39227411325509093 -0.03758874622345811 -1.1040981732166661 1.9714140711314037 374 226.0 347 0 0 True 3169 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +niacin niacin BRD-K60237333;BRD-K61993165 13 3 HEPG2;HUH7;PHH 0.001737899871336 -0.1045087344116634 -0.067487504865442 -0.112603498622775 -0.1181280655520302 -0.280858473822711 -0.7310886033884589 0.07692307692307693 2 -0.0069912977309691 0.0514837760064336 -0.15410940675064916 -0.1181280655520302 True False -0.6464027755169405 -0.04078559307987423 -0.7664711006776987 -0.007346667488711169 375 442.0 473 0 1 True 888706;938 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +domperidone domperidone BRD-K38305202 3 2 HEPG2;PHH 0.0751000065356493 0.001095979681445508 -0.031385709132467 -0.0758283473551273 -0.1900062542408704 -0.218245394113991 -0.3529017268872213 0.0 1 0.0751000065356493 0.0751000065356493 -0.1900062542408704 -0.1900062542408704 False False -0.3946962575576016 -0.041772762525650466 -0.7325080955762844 0.7977526154754899 376 320.0 365 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +candesartan-cilextil candesartan-cilextil BRD-A65671304 3 2 HEPG2;PHH 0.0920777854820092 -0.256965461290545 -0.2483785493033272 0.0892377514392137 -0.2483785493033272 -0.2438797998862962 -0.3060060214022145 0.0 1 0.0920777854820092 0.0920777854820092 -0.2483785493033272 -0.2483785493033272 False False -0.3968828105874035 -0.04554981805153967 -1.0370953362001853 0.10064548819579316 377 327.0 439 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dipyridamole dipyridamole BRD-K86301799 3 2 HEPG2;PHH -0.1007509608235624 -0.1135345658080445 -0.0444834700652531 0.1410549636930227 -0.0501064778072759 -0.10421890828995 -0.5875084698126313 0.0 1 -0.1007509608235624 -0.1007509608235624 -0.0501064778072759 -0.0501064778072759 False False -0.39797314319626564 -0.047433260506046786 0.2346619972467402 -0.6989587498805888 378 403.0 432 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +barasertib-hqpa barasertib-HQPA BRD-K63923597 9 2 HEPG2;PHH -0.0470398991472191 -0.2806365307834413 0.0356883832386561 0.0579055529087781 -0.0210840664803981 -0.2055300336575047 -0.4041875955973943 0.0 1 -0.0470398991472191 -0.0470398991472191 -0.0210840664803981 -0.0210840664803981 False False -0.40762383145620185 -0.0641038762761702 0.30001651092173043 -0.873854607146499 380 343.0 364 0 1 True 16007391 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sb-205607 SB-205607 BRD-A11609859;BRD-K22878149 3 2 HEPG2;PHH 0.262333202900158 0.047336969007220564 0.2328992443425314 -0.1070191282778978 -0.2561513100351606 -0.2444490894290899 -0.3423638668221732 0.0 2 0.07685191494723166 0.262333202900158 -0.4095307346433401 0.06554670099701199 False True -0.4156310228401765 -0.07793551266983885 -0.204900004541652 2.154273190267455 381 59.0 201 2 1 True 23581823;3277599 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k48576794 BRD-K48576794 BRD-K48576794 3 2 HEPG2;PHH -0.393302525083224 -0.44906792511594384 0.1198507440941674 0.1145984092727303 0.1145984092727303 -0.2760779483997751 -0.28881426283069667 0.0 1 -0.393302525083224 -0.393302525083224 0.1145984092727303 0.1145984092727303 False False -0.42048507981512345 -0.08632041917350859 1.0682633259557153 -3.6418455197803414 383 541.0 567 0 0 True 566661 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +flumetasone flumetasone BRD-A01346607;BRD-K61496577 3 2 HEPG2;PHH -0.1611805591318342 -0.20440416969358915 -0.075923816966159 0.1411812584847211 -0.1105749923735857 -0.2706099044945504 -0.30926419575033437 0.0 2 -0.20440416969358915 0.1434684743483861 -0.119619635465954 -0.075923816966159 True False -0.4252420023697176 -0.09453753550966482 -0.013666041499688624 -1.374269777216933 384 472.0 491 0 1 True 16490;5702178 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k75627148 BRD-K75627148 BRD-K75627148 18 3 HEPG2;HUH7;PHH -0.25055018108752036 -0.4767831713995999 0.0034428808305944506 0.20016719773411745 -0.0383538710219519 -0.24550665240173064 -0.72940496961394 0.05555555555555555 1 -0.25055018108752036 -0.25055018108752036 -0.0383538710219519 -0.0383538710219519 False False -0.6102091372087006 -0.09931615248810322 0.5847284858359374 -2.8045125346606428 385 488.0 532 0 0 True 54646518 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dcpib DCPIB BRD-A39255369 3 2 HEPG2;PHH 0.1849490900834401 0.109368150251814 -0.1861420539872987 -0.1645108936354518 -0.1861420539872987 -0.2585351678675839 -0.33964375611985964 0.0 1 0.1849490900834401 0.1849490900834401 -0.1861420539872987 -0.1861420539872987 False False -0.4283570459275137 -0.09991846719666149 -1.450392494948919 1.84736528341473 386 329.0 449 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +caffeic-acid-phenethyl-ester caffeic-acid-phenethyl-ester BRD-K96188950 12 3 HEPG2;HUH7;PHH 0.09762829066150716 -0.09671441977843641 -0.2815392304744039 0.1556590218096971 -0.2815392304744039 -0.5068197084539052 -0.9392397947616816 0.16666666666666666 1 0.09762829066150716 0.09762829066150716 -0.2815392304744039 -0.2815392304744039 False False -0.976439605834746 -0.10247543403345372 -1.022505476285476 0.637703881833282 387 303.0 460 0 0 True 5281787 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +icariin icariin BRD-K65639003 3 2 HEPG2;PHH -0.0357999958925777 -0.042210183287453296 0.0365238168409892 -0.1213000118732452 -0.1213000118732452 -0.2601381112185735 -0.3426720955490415 0.0 1 -0.0357999958925777 -0.0357999958925777 -0.1213000118732452 -0.1213000118732452 False False -0.43147415899309427 -0.10530297375502258 -0.4896389636547457 -0.055503063990640505 388 426.0 496 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cetirizine cetirizine BRD-A42571354 3 2 HEPG2;PHH -0.3252201183802551 -0.5121531107773383 0.211435711809567 0.0687201470136642 0.0687201470136642 -0.2243901240890697 -0.43155410210971556 0.0 1 -0.3252201183802551 -0.3252201183802551 0.0687201470136642 0.0687201470136642 False False -0.44016717514392745 -0.12031930504982032 1.0875224957403655 -3.3984414622336603 389 512.0 550 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mitomycin-c mitomycin-c BRD-A48237631 3 2 HEPG2;PHH -0.183113872177071 -0.2711377860202143 0.3432748019695282 -0.232318740338087 -0.232318740338087 -0.1822799244333827 -0.5228628428941149 0.0 1 -0.183113872177071 -0.183113872177071 -0.232318740338087 -0.232318740338087 False False -0.44371134588044014 -0.12644151177546883 -0.1885386734347666 -1.7249260160218904 390 471.0 564 0 1 True 15560563 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pk-11195 PK-11195 BRD-A41451487 3 2 HEPG2;PHH 0.0195847493078973 -0.02743410526050465 -0.0968559959105083 0.0634878799319267 -0.0968559959105083 -0.1423833025471558 -0.6041508809707703 0.0 1 0.0195847493078973 0.0195847493078973 -0.0968559959105083 -0.0968559959105083 False False -0.44445874303254096 -0.12773256692249724 -0.27341037605730917 0.3491968725662386 391 339.0 374 0 1 True 1345 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k32602441 BRD-K32602441 BRD-K32602441 12 3 HEPG2;HUH7;PHH 0.07145348429265945 -0.007552564971976849 0.005924171635082701 -0.048062436748296 -0.24756427814385715 -0.44336027007490864 -0.5596144658454235 0.08333333333333333 1 0.07145348429265945 0.07145348429265945 -0.24756427814385715 -0.24756427814385715 False False -0.7231675029976203 -0.13707366347169492 -0.6852277540622336 0.747104100023273 392 288.0 341 0 0 True 54631468 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gangaleoidin gangaleoidin BRD-K41603276 12 3 HEPG2;HUH7;PHH -0.05223719128924935 -0.23242788482457394 -0.22808047011494637 0.06656448985449964 -0.22808047011494637 -0.30539013777807766 -0.8372782500357264 0.08333333333333333 1 -0.05223719128924935 -0.05223719128924935 -0.22808047011494637 -0.22808047011494637 False False -0.7240292627959408 -0.13856226885371514 -0.9922618648136583 -0.7567391534784367 393 477.0 512 0 0 True 4565183 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +methysergide methysergide BRD-A98725278;BRD-K35941380 5 2 HEPG2;PHH 0.0685169624371661 -0.0080247033490902 -0.0036582457167761 -0.0024250112473964 -0.0449375007301569 -0.1527071537242995 -0.6083148978354911 0.0 2 -0.0080247033490902 0.1129459665260381 -0.3875920474529266 -0.0449375007301569 True False -0.45686460264204504 -0.14916247049804832 -0.059003663495204806 0.7266202152375003 394 267.0 301 0 1 True 4163 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ly-2183240 LY-2183240 BRD-K37865504 14 3 HEPG2;HUH7;PHH -0.0623472425051861 -0.20503022542430288 -0.09409262994969525 0.0523614673875272 -0.1431227778749806 -0.23365938592894325 -0.44752122225269436 0.0 1 -0.0623472425051861 -0.0623472425051861 -0.1431227778749806 -0.1431227778749806 False False -0.45741999705529046 -0.15012185977834705 -0.4167891605878157 -0.736502222702454 395 415.0 440 0 1 True 11507802 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +carbenoxolone carbenoxolone BRD-A98702003;BRD-K12765235 4 2 HEPG2;PHH -0.027480214006371004 -0.13492839995564684 -0.048350227198430504 0.0270648249424994 -0.22072813101112843 -0.19992500045780265 -0.5219855226635459 0.0 2 -0.1421769353457623 0.28612360937727815 -0.2210422759609563 -0.22072813101112843 True False -0.4609177617895756 -0.15616390469462757 -0.5542248764446859 -0.2915960761050063 396 371.0 385 0 1 True 12866477 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brompheniramine brompheniramine BRD-A68723818 3 2 HEPG2;PHH 0.1404416685303052 0.12691806380947426 -0.5630809792450496 -0.38760672416538 -0.5630809792450496 -0.8643650849615889 -1.3881714616879999 0.3333333333333333 1 0.1404416685303052 0.1404416685303052 -0.5630809792450496 -0.5630809792450496 False False -1.558450815805589 -0.1636408102991882 -4.208649718280816 1.6141604312114122 397 551.0 573 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k77508012 BRD-K77508012 BRD-K77508012 12 3 HEPG2;HUH7;PHH 0.0036456597348053996 -0.1018651091597146 -0.036283524706959655 -0.11149040702730416 -0.13379267696291205 -0.19015553589939835 -0.5598051834164098 0.0 1 0.0036456597348053996 0.0036456597348053996 -0.13379267696291205 -0.13379267696291205 False False -0.47005812760760324 -0.17195298858652772 -0.7099368989520024 0.013268872535826096 398 423.0 469 0 0 True 610065 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +vinblastine vinblastine BRD-A22783572;BRD-A55594068;BRD-K01188359 15 3 HEPG2;HUH7;PHH 0.0822333461708492 -0.2414817311801016 -0.0556339429957526 0.0836999963503331 -0.0695012281648814 -0.3766854028734896 -1.0718034883916734 0.13333333333333333 3 -0.3349654187137882 0.10211498766309679 -0.6619791228856359 -0.061819895835859395 True False -0.9125871470693263 -0.18101694618942687 -0.01976097109801464 0.08534485581792445 399 227.0 272 0 1 True 3823887;5388983;5667;6710780 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k81826010 BRD-K81826010 BRD-K81826010 12 3 HEPG2;HUH7;PHH -0.14326972493694884 -0.3853443275309271 -0.06726888567209245 0.24003474880009884 -0.06726888567209245 -0.18561994722149966 -0.5801128081724211 0.0 1 -0.14326972493694884 -0.14326972493694884 -0.06726888567209245 -0.06726888567209245 False False -0.4756763513077102 -0.18165791802704237 0.4185370800634258 -1.8241665705049672 400 405.0 477 0 0 True 54654538 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pravastatin pravastatin BRD-A71816415;BRD-K60511616 4 2 HEPG2;PHH 0.16883975826203818 0.11928766293244226 0.07046548862542425 -0.2610168219543993 -0.2610168219543993 -0.22938884528619907 -0.5095867549941416 0.0 2 0.12895397303832895 0.222963887370295 -0.3764192573726177 -0.13851249490731526 False False -0.4841822227832699 -0.196350975282634 -1.1633344949818283 1.774113223223381 401 258.0 459 0 1 True 22833647;4889;54687;6728942 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +h-9 H-9 BRD-K09790412;BRD-K70577657 3 2 HEPG2;PHH -0.2957387523104747 -0.3060746122565534 -0.0002762036664145 -0.0138955824077129 -0.0138955824077129 -0.1523810815184362 -0.6727000577855736 0.0 2 -0.2957387523104747 -0.029603408960004657 -0.3727378504616873 -0.0070858930370637 False False -0.488731110411223 -0.2042087317228546 -0.0037615612005082455 -2.563174145720919 402 548.0 559 0 1 True 24113957;3544 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a15113563 BRD-A15113563 BRD-A15113563 12 3 HEPG2;HUH7;PHH -0.084862766166528 -0.1757906772092812 -0.05929009829248699 0.1340647982433438 -0.15539099568767206 -0.3087233784183534 -0.37469135939757087 0.0 1 -0.084862766166528 -0.084862766166528 -0.15539099568767206 -0.15539099568767206 False False -0.49606905811713886 -0.21688431541717135 -0.09987894155498922 -0.79080317466075 403 398.0 426 0 0 True 2806677 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k83694683 BRD-K83694683 BRD-K83694683 18 3 HEPG2;HUH7;PHH -0.013602270434300099 -0.14419370387784305 -0.10914312728813715 0.0184748836327344 -0.183376498121236 -0.3150063047281629 -1.4566708538137998 0.16666666666666666 1 -0.013602270434300099 -0.013602270434300099 -0.183376498121236 -0.183376498121236 False False -1.0433417316350628 -0.21804228308934848 -0.666080925286209 -0.2307414610555844 404 407.0 414 0 0 True 54631469 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +norgestimate norgestimate BRD-A04756508 3 2 HEPG2;PHH -0.4104444409410159 -0.4186361972242594 -0.0446428528853825 -0.1139875026419758 -0.1498124971985817 -0.1998297417211154 -0.6026482637786854 0.0 1 -0.4104444409410159 -0.4104444409410159 -0.1498124971985817 -0.1498124971985817 False False -0.5011538736104582 -0.22566783458885548 -0.7833805860553195 -3.657636202922676 405 570.0 574 0 1 True 73707471 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +arctigenin arctigenin BRD-K53523901 13 3 HEPG2;HUH7;PHH -0.1379458804925283 -0.4390829540789127 0.1296602008598191 0.191098378971219 0.0355920940637588 -0.2527051059351791 -0.5154997177629007 0.0 1 -0.1379458804925283 -0.1379458804925283 0.0355920940637588 0.0355920940637588 False False -0.5104549648166294 -0.24173455579719139 1.1241454627585117 -1.957756035122158 406 311.0 431 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pifithrin-mu pifithrin-mu BRD-K96799727 10 2 HEPG2;PHH -0.21452312709556687 -0.35505303285188144 0.02307725165571485 -0.026066080667078502 -0.08432545512914655 -0.461748610302392 -0.7686120215618598 0.1 1 -0.21452312709556687 -0.21452312709556687 -0.08432545512914655 -0.08432545512914655 False False -0.846054621083322 -0.2549289055436641 -0.15052982012791055 -2.1906476200141194 407 522.0 529 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gitoxigenin gitoxigenin BRD-A29082194 3 2 HEPG2;PHH -0.1142672308617168 -0.12817800997032058 -0.0198270699807575 -0.0516915544867515 -0.0516915544867515 -0.2553854330428062 -0.5302127643917052 0.0 1 -0.1142672308617168 -0.1142672308617168 -0.0516915544867515 -0.0516915544867515 False False -0.5204918152386588 -0.25907222876114633 -0.27190632838044615 -0.8322389059146109 408 471.0 500 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +midodrine midodrine BRD-A79981887 3 2 HEPG2;PHH -0.2297825635307365 -0.2410801750504308 -0.0792357133967535 0.0255917012691497 -0.0792357133967535 -0.3285206206704653 -0.4006958978679327 0.0 1 -0.2297825635307365 -0.2297825635307365 -0.0792357133967535 -0.0792357133967535 False False -0.5288685696044316 -0.27354224889558854 -0.28894322114063703 -1.933006652597748 409 522.0 540 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a73594579 BRD-A73594579 BRD-A73594579 12 3 HEPG2;HUH7;PHH 0.0267335923595561 -0.2000807276409533 0.0726647254611764 -0.0787308309227228 -0.2281716987490654 -0.22366604764783193 -0.6131629526304702 0.0 1 0.0267335923595561 0.0267335923595561 -0.2281716987490654 -0.2281716987490654 False False -0.5302475239630671 -0.27592425706518 -0.5277710563128228 -0.14442457129501962 410 317.0 424 0 0 True 6621824 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +l-701324 L-701324 BRD-K08109516 3 2 HEPG2;PHH -0.0576217489110098 -0.05978425333483345 0.2096852362155914 -0.1823791780043393 -0.1823791780043393 -0.3413490987353264 -0.3988068339244891 0.0 1 -0.0576217489110098 -0.0576217489110098 -0.1823791780043393 -0.1823791780043393 False False -0.540752515697571 -0.294070598150639 -0.31083985200675807 -0.25170724870504496 411 395.0 521 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k84245233 BRD-K84245233 BRD-K84245233 12 3 HEPG2;HUH7;PHH 0.02717311100827315 -0.10106514963424863 -0.1267594088401113 0.12099999189376826 -0.20041192199901806 -0.41308119959227496 -0.804232053709076 0.08333333333333333 1 0.02717311100827315 0.02717311100827315 -0.20041192199901806 -0.20041192199901806 False False -0.815197226446813 -0.2960459686306175 -0.45582869192367226 0.16805825928918516 412 316.0 394 0 0 True 54654203 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +chlorthalidone chlorthalidone BRD-A26384407 4 2 HEPG2;PHH 0.10335401528411439 -0.0073241888441973185 -0.13026350204433712 -0.09191656624898309 -0.15536573642332635 -0.31931241289416823 -0.4466217408429772 0.0 1 0.10335401528411439 0.10335401528411439 -0.15536573642332635 -0.15536573642332635 False False -0.5426232833156568 -0.2973021654043204 -0.9875736277888368 0.9543030716407326 413 352.0 423 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dienestrol dienestrol BRD-K95309561 15 2 HEPG2;PHH 0.1323262022601233 -0.03212603450649315 -0.2262393832206726 -0.1175761027261614 -0.2356977201998233 -0.3956474033997409 -0.7402535561945232 0.06666666666666667 1 0.1323262022601233 0.1323262022601233 -0.2356977201998233 -0.2356977201998233 False False -0.7657741814970025 -0.30509269491264235 -1.5567435539768226 1.0642739432336124 414 387.0 477 0 1 True 667476 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tretinoin tretinoin BRD-K06926592;BRD-K64634304;BRD-K71879491 4 2 HEPG2;PHH 0.028854211999310396 -0.05343652620083748 -0.2271065275583948 0.08370459033176304 -0.2271065275583948 -0.2541998665232862 -0.5869730959760971 0.0 3 -0.0633880413240856 0.3591750208288431 -0.354910708963871 0.1689091771841049 True True -0.5476864145113347 -0.3060482270823535 -0.935617231781084 0.3278821447030285 415 394.0 472 0 1 True 444795;445354 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +desoxypeganine desoxypeganine BRD-K13819402 3 2 HEPG2;PHH 0.26257776386208 0.05063887954586077 -0.1618642870868955 0.078055091202259 -0.1618642870868955 -0.1903178209350222 -0.7227272619862877 0.0 1 0.26257776386208 0.26257776386208 -0.1618642870868955 -0.1618642870868955 False False -0.5516814519281661 -0.31294926169972315 -0.590534868583992 2.166181792123231 416 116.0 214 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a41649729 BRD-A41649729 BRD-A41649729 12 3 HEPG2;HUH7;PHH 0.05000727758225465 -0.0365911544197135 -0.2355618114982332 0.03686610097065565 -0.300466560292989 -0.46604390267933166 -0.7234898117843955 0.08333333333333333 1 0.05000727758225465 0.05000727758225465 -0.300466560292989 -0.300466560292989 False False -0.8277888085715295 -0.3177966896035991 -1.2886176318435592 0.5174793105902263 417 401.0 461 0 0 True 3136666 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +deoxyandirobin deoxyandirobin BRD-A58269583 3 2 HEPG2;PHH 0.4536257137854894 0.1426238301727507 -0.412107305335147 0.028551448136568 -0.412107305335147 -0.9716935042764931 -1.3573572450125264 0.3333333333333333 1 0.4536257137854894 0.4536257137854894 -0.412107305335147 -0.412107305335147 False False -1.6503721267827562 -0.32242584356442316 -2.1269065136898533 3.6904432476758853 418 84.0 296 2 0 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k46123637 BRD-K46123637 BRD-K46123637 12 3 HEPG2;HUH7;PHH -0.1659698871274789 -0.20411757390118304 -0.05981837638786855 0.07874453812837595 -0.15384777382548365 -0.23759557129741304 -0.6415293457296988 0.0 1 -0.1659698871274789 -0.1659698871274789 -0.15384777382548365 -0.15384777382548365 False False -0.5583602441622624 -0.3244862190797805 -0.26289214709954534 -1.4043737641233245 419 486.0 499 0 0 True 54618962 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ncs-382 NCS-382 BRD-A67433117;BRD-A85025557 5 2 HEPG2;PHH 0.0125844019154707 -0.0858408415483103 -0.3203008387769971 0.0278235394507646 -0.3203008387769971 -0.3551415182531825 -0.4182885839116005 0.0 2 -0.11926764415370089 0.3136877963940302 -0.3203008387769971 -0.15802395889269455 True False -0.5642858102089827 -0.3347220522270857 -1.6197293218857338 0.1212378043331743 420 479.0 521 0 1 True 5875451 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sappanone-a sappanone-a BRD-K03557653 3 2 HEPG2;PHH -0.0129388827416631 -0.10639125750296641 -0.1135214396885463 0.0900068022310733 -0.1135214396885463 -0.2242255117596378 -0.6838713498150427 0.0 1 -0.0129388827416631 -0.0129388827416631 -0.1135214396885463 -0.1135214396885463 False False -0.5661611866671592 -0.3379615807991962 -0.2865927782311451 -0.10823306463261126 421 368.0 414 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dihydroergotamine dihydroergotamine BRD-K72166146 3 2 HEPG2;PHH -0.0159076802018615 -0.04067883899228435 -0.1388809233903885 0.0606949850916862 -0.1388809233903885 -0.3374160099774599 -0.47047314337188645 0.0 1 -0.0159076802018615 -0.0159076802018615 -0.1388809233903885 -0.1388809233903885 False False -0.5726525816634032 -0.3491748278630072 -0.514919204614674 0.07804408592763046 422 404.0 437 0 1 True 73707468 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +clobetasol clobetasol BRD-A26095496;BRD-A63894585 5 2 HEPG2;PHH -0.2419761584864722 -0.298959252734979 -0.2537071364266531 0.2016763547435403 -0.3397875055670738 -0.2295299161018597 -0.7041174615659411 0.0 2 -0.4058563912080394 0.1023111177815331 -0.3397875055670738 -0.1224076743237674 True False -0.5815886468848303 -0.3646110025472114 -0.9507620263232054 -2.1929303433370455 423 540.0 563 0 1 True 32798;40469415 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tetrahydropalmatine tetrahydropalmatine BRD-A43940795 3 2 HEPG2;PHH -0.2222044703861077 -0.23297671466651884 -0.1248142836349351 -0.0349517129361629 -0.1248142836349351 -0.3597651035303161 -0.44665768328640193 0.0 1 -0.2222044703861077 -0.2222044703861077 -0.1248142836349351 -0.1248142836349351 False False -0.5830939451735171 -0.36721125744242944 -0.7228157991841004 -1.8586145504789966 424 538.0 550 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ornidazole ornidazole BRD-A42759514 3 2 HEPG2;PHH 0.0758000107275115 0.013398615850342646 -0.1804530588643891 -0.0308437431231141 -0.1804530588643891 -0.3518818059182238 -0.4667665578151447 0.0 1 0.0758000107275115 0.0758000107275115 -0.1804530588643891 -0.1804530588643891 False False -0.5852650848257962 -0.37096168787304246 -1.019225452941516 0.8407559396605003 425 375.0 430 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k77634909 BRD-K77634909 BRD-K77634909 12 3 HEPG2;HUH7;PHH 0.04267278313636775 -0.07821913420533134 -0.18772305335317335 0.025649775750935102 -0.27104570796447136 -0.5068074149404844 -0.7214390801262139 0.08333333333333333 1 0.04267278313636775 0.04267278313636775 -0.27104570796447136 -0.27104570796447136 False False -0.8675269550035913 -0.38644043321470856 -1.1038577669914824 0.33982730461984995 426 387.0 428 0 0 True 698112 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +benzoxiquine benzoxiquine BRD-K70327191 3 2 HEPG2;PHH -0.1664444481333097 -0.22152250389465022 -0.0343928549970899 0.0272624939680099 -0.1050625070929527 -0.2781686624364247 -0.6373909444562973 0.0 1 -0.1664444481333097 -0.1664444481333097 -0.1050625070929527 -0.1050625070929527 False False -0.5968641346645733 -0.390997906840294 -0.2159684406146691 -1.4618735547544572 427 488.0 505 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ro-90-7501 Ro-90-7501 BRD-K58299615 12 3 HEPG2;HUH7;PHH -0.0337854847311973 -0.1904336071262756 -0.04453957027622625 -0.01556098042055965 -0.2432146756244557 -0.5423565924034587 -0.655766139413038 0.08333333333333333 1 -0.0337854847311973 -0.0337854847311973 -0.2432146756244557 -0.2432146756244557 False False -0.8702396621099777 -0.3911263682122348 -0.7277980055172879 -0.5059825161809042 428 405.0 421 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nimodipine nimodipine BRD-A24891640;BRD-A58048407 5 2 HEPG2;PHH -0.1734782600154479 -0.2536027804017067 -0.01291481086186 0.0250266231596469 -0.01291481086186 -0.3052028260592903 -0.590249175176261 0.0 2 -0.21354052020857728 -0.1405609763330883 -0.2080916278064251 -0.0070931187697819 False False -0.6003274136474208 -0.3969803810092582 0.07732378859384328 -1.6077220799225111 429 493.0 506 0 1 True 4497 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +clofibrate clofibrate BRD-K45252063 3 2 HEPG2;PHH -0.0673694494697782 -0.1995319467451837 0.009948506951332 -0.2742626667022705 -0.2742626667022705 -0.2724207358227836 -0.6623808136062015 0.0 1 -0.0673694494697782 -0.0673694494697782 -0.2742626667022705 -0.2742626667022705 False False -0.6036111426258843 -0.40265270018678667 -1.4177422061006417 -0.7518157957646838 430 517.0 556 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k62056344 BRD-K62056344 BRD-K62056344 12 3 HEPG2;HUH7;PHH -0.02100522153907345 -0.10288584397898773 -0.1075303937707628 0.008308757096529 -0.2128225384346608 -0.2753001290765251 -0.6572370480797771 0.0 1 -0.02100522153907345 -0.02100522153907345 -0.2128225384346608 -0.2128225384346608 False False -0.6039186531164137 -0.4031838943456716 -0.7669916086753359 -0.14948261879295208 431 416.0 425 0 0 True 54654476 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cimetidine cimetidine BRD-K18618618;BRD-K34157611 5 2 HEPG2;PHH -0.0663967712057961 -0.0873666703701019 -0.1614857167005539 0.2122000008821487 -0.1662062499672174 -0.222088692502843 -0.7671495674710188 0.0 2 -0.1447643890149063 0.1910666657818688 -0.1662062499672174 -0.0684805505110749 True False -0.6056634762383524 -0.4061979048565509 -0.19948026336955046 -0.3947606853619055 432 390.0 487 0 1 True True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mifepristone mifepristone BRD-A44780397;BRD-K37270826 3 2 HEPG2;PHH -0.0291212221814526 -0.1316106089701255 -0.1009897919637816 -0.083784251473844 -0.1009897919637816 -0.3339732296114403 -0.5441421351639465 0.0 2 -0.1316106089701255 0.1149582266807556 -0.2976064090617001 -0.1009897919637816 True False -0.6060442971934136 -0.4068557356400186 -0.7366216743215762 -0.29184266895714084 433 467.0 480 0 1 True 4196;55245;7048709 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +doxylamine doxylamine BRD-A44008656 3 2 HEPG2;PHH 0.0116553946087757 -0.05424452335056336 0.1217476235968726 -0.2871336750686168 -0.2871336750686168 -0.2798000749732767 -0.6624403629407642 0.0 1 0.0116553946087757 0.0116553946087757 -0.2871336750686168 -0.2871336750686168 False False -0.6110202564436589 -0.4154512163471303 -1.1549237404920882 0.21403141493361805 434 426.0 541 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +suloctidil suloctidil BRD-A34205397;BRD-K42635745 5 2 HEPG2;PHH -0.0575027734869056 -0.0880388965209325 -0.164900004863739 0.0884357467293739 -0.2028531985623496 -0.2759900525330551 -0.6731403000238869 0.0 2 -0.2735597142535779 0.0854984712269571 -0.22674285088266644 -0.2028531985623496 True False -0.6125602025449985 -0.418111321934491 -0.6734501103679751 -0.3392940444256731 435 428.0 485 0 1 True 5354 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +calpeptin calpeptin BRD-A84045418;BRD-K26134695 3 2 HEPG2;PHH 0.2203697891285022 -0.1447507916535768 -0.0657188573053905 -0.0725128073245287 -0.3424114771187305 -0.3644058321203504 -0.5131311980519622 0.0 2 -0.5098713724356558 0.286823169949154 -0.3826982259218181 0.1848264038562774 True True -0.6209714311463315 -0.4326408929237026 -1.2151769808365216 1.2819637774788075 436 172.0 290 0 1 True 2532;73364 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +toltrazuril toltrazuril BRD-K64514229 3 2 HEPG2;PHH 0.0166361033916473 -0.0259041703409619 -0.3103856997830527 0.0747812576591968 -0.3103856997830527 -0.3826272063223379 -0.485303127339908 0.0 1 0.0166361033916473 0.0166361033916473 -0.3103856997830527 -0.3103856997830527 False False -0.6252787699922919 -0.4400813975756691 -1.4243367797565392 0.33489532258541815 437 451.0 517 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +lapatinib lapatinib BRD-K19687926;BRD-M07438658 3 2 HEPG2;PHH 0.0511519743336571 -0.020672858020083805 -0.2367425624813352 -0.0522405225783586 -0.2367425624813352 -0.319245962618244 -0.6184269119911487 0.0 2 -0.0206728580200838 0.9929160434338782 -0.31820682063698763 -0.2367425624813352 True False -0.6284594186138184 -0.4455756555644346 -1.3954929934009712 0.5746677891126827 438 446.0 490 0 1 True 208908;73707431 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k65258912 BRD-K65258912 BRD-K65258912 3 2 HEPG2;PHH 0.3065322546495331 0.19576936566995246 -0.2304074849401201 -0.04559156158939 -0.2716443054378032 -0.3986042739845635 -0.47678288838656124 0.0 1 0.3065322546495331 0.3065322546495331 -0.2716443054378032 -0.2716443054378032 False False -0.6369957181778441 -0.4603212743532323 -1.4459754110574252 2.9045359013164225 439 146.0 322 1 0 True 2345373 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +penitrem-a penitrem-a BRD-K03842655 3 2 HEPG2;PHH 0.0082801315519544 -0.021039713536285698 -0.0860521069594792 0.1307026483118534 -0.2034161761403083 -0.4349755251277533 -0.4382768996680776 0.0 1 0.0082801315519544 0.0082801315519544 -0.2034161761403083 -0.2034161761403083 False False -0.6541139749617921 -0.48989138104543556 -0.3128125222378692 0.2960209912376898 440 308.0 375 0 1 True 16759989 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nizatidine nizatidine BRD-K46652470;BRD-K73589491 4 2 HEPG2;PHH 0.0729978049380911 -0.038476675334903995 -0.1511902638844081 -0.14578437805175776 -0.2306075362222535 -0.4087238494262454 -0.5141195516981598 0.0 2 -0.04809446074068549 0.10657779613716731 -0.28943928437573563 -0.2110192190323557 True False -0.6657836252753253 -0.510049555396194 -1.4036871709542331 0.6603953751642293 441 430.0 486 0 1 True 3033637;5353831 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +phorbol-myristate-acetate phorbol-myristate-acetate BRD-K68552125 12 3 HEPG2;HUH7;PHH -0.16753255182670218 -0.21775365827812088 -0.10728657139199116 0.2288716968614608 -0.20247331208416391 -0.5068023317319799 -0.8655833021186972 0.08333333333333333 1 -0.16753255182670218 -0.16753255182670218 -0.20247331208416391 -0.20247331208416391 False False -0.9395939827913284 -0.5109291429921928 -0.08040081652290054 -1.4571308023317397 442 456.0 507 0 0 True 27924 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ttnpb TTNPB BRD-K49685476;BRD-K68246049 4 2 HEPG2;PHH -0.09314571874630115 -0.1189027682412415 0.04983587429991785 0.039981388486921746 -0.1420365654464279 -0.2651230337625806 -0.8413901941551428 0.0 2 -0.12550831689602795 0.0391077310778201 -0.21200657097090575 -0.1420365654464279 True False -0.6858181308401521 -0.5446571953302431 -0.020740211587155347 -0.6665190147410632 443 399.0 426 0 1 True 5289501;5354022 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +benzopurpurin-4b benzopurpurin-4b BRD-K14221570 3 2 HEPG2;PHH 0.0236138775944709 -0.12147236967252367 -0.0573579860585076 -0.034509167773649 -0.2063999942370823 -0.398529172943358 -0.5812585002286286 0.0 1 0.0236138775944709 0.0236138775944709 -0.2063999942370823 -0.2063999942370823 False False -0.6891584230576723 -0.5504272219457936 -0.7285724903317581 0.08120344080307451 444 365.0 389 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gw-7647 GW-7647 BRD-K96263742 3 2 HEPG2;PHH 0.096711103287008 -0.43631806431545156 -0.4824524032218115 0.0176208410412073 -0.4824524032218115 -0.7742314190411614 -2.023599571067958 0.3333333333333333 1 0.096711103287008 0.096711103287008 -0.4824524032218115 -0.4824524032218115 False False -1.7860312045751405 -0.5567635716821764 -2.549867098235856 -0.4302290718414643 445 480.0 544 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +benzthiazide benzthiazide BRD-K21450440 3 2 HEPG2;PHH 0.1657434979246722 0.026843967330124646 -0.1611154515828405 0.1751312464475631 -0.3860923377797007 -0.425533173576234 -0.5562660385011917 0.0 1 0.1657434979246722 0.1657434979246722 -0.3860923377797007 -0.3860923377797007 False False -0.7036661928268299 -0.5754879688053794 -0.8717873308805317 1.4649852670699945 446 142.0 295 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +verapamil verapamil BRD-A09533288 3 2 HEPG2;PHH 0.4199221680561701 0.15000865277316833 -0.415551381451743 -0.0212862910702824 -0.415551381451743 -0.3151905806882987 -0.7791240997242903 0.0 1 0.4199221680561701 0.4199221680561701 -0.415551381451743 -0.415551381451743 False False -0.7047526305504439 -0.5773646832283005 -2.295006770682666 3.495381495412928 447 123.0 353 2 1 True 62969 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +parthenolide parthenolide BRD-A66395008;BRD-K81651477;BRD-K98548675 5 2 HEPG2;PHH 0.0746439384917418 -0.0210054587158891 -0.3737464132053511 0.2090087477117777 -0.3737464132053511 -0.2528749212145893 -0.925896322709464 0.0 3 -0.0210054587158891 0.4224032859007517 -0.4601073520524161 -0.161009811929294 True False -0.7158230825693213 -0.5964878013974405 -1.3745906572485151 0.7256857746454679 448 351.0 520 0 1 True 24870789;44593496;5420804;6473881 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k51644197 BRD-K51644197 BRD-K51644197 12 3 HEPG2;HUH7;PHH -0.2299744714465406 -0.3558898125257757 -0.0505491681396961 0.010967390611767748 -0.13046787569432383 -0.5377775647396607 -0.9127405785866791 0.08333333333333333 1 -0.2299744714465406 -0.2299744714465406 -0.13046787569432383 -0.13046787569432383 False False -0.9941478540330002 -0.605165595538087 -0.3779849474671734 -2.2932773662698205 449 513.0 539 0 0 True 6484054 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +plx-4720 PLX-4720 BRD-K16478699 3 2 HEPG2;PHH -0.1889357649617725 -0.30428194337420994 -0.1593225156622273 0.1813469552434981 -0.1593225156622273 -0.4551332406995315 -0.5409961448601698 0.0 1 -0.1889357649617725 -0.1889357649617725 -0.1593225156622273 -0.1593225156622273 False False -0.7256313131296164 -0.6134305560125961 -0.2676372539617146 -1.8662569971663738 450 508.0 539 0 1 True 24180719 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pipamperone pipamperone BRD-K26801045 3 2 HEPG2;PHH 0.2131361129383246 0.176678164758616 -0.3612785594803946 0.0646812692284584 -0.3612785594803946 -0.4358460094691032 -0.6166180170377686 0.0 1 0.2131361129383246 0.2131361129383246 -0.3612785594803946 -0.3612785594803946 False False -0.7441550179879874 -0.6454284361653546 -1.7368908387363375 2.240302839373852 451 269.0 432 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ilomastat ilomastat BRD-K51662849 3 2 HEPG2;PHH -0.2100500075353516 -0.22912858178218198 -0.1970214247703552 0.2321875002235174 -0.1970214247703552 -0.4879991069643034 -0.5229041447182969 0.0 1 -0.2100500075353516 -0.2100500075353516 -0.1970214247703552 -0.1970214247703552 False False -0.7494511793234518 -0.6545770345142039 -0.3248052903420362 -1.7679077654717705 452 513.0 548 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +bisoprolol bisoprolol BRD-A89175223 3 2 HEPG2;PHH -0.0018222365114423 -0.0621000070952706 -0.1852785732064928 -0.1138187535107135 -0.2388125024735927 -0.4987559102416511 -0.5085301443431822 0.0 1 -0.0018222365114423 -0.0018222365114423 -0.2388125024735927 -0.2388125024735927 False False -0.7530209824132422 -0.6607435186117109 -1.4310260620950208 0.10222842356775064 453 476.0 513 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +betamethasone-acetate betamethasone-acetate BRD-A92177080 3 2 HEPG2;PHH 0.0157388829522662 -0.02460555649465985 0.1304785673107419 -0.1734664663672447 -0.226281251758337 -0.452273215802889 -0.6158328740266226 0.0 1 0.0157388829522662 0.0157388829522662 -0.226281251758337 -0.226281251758337 False False -0.7601896528162002 -0.6731266923969927 -0.6333135261038626 0.33314879914466916 454 349.0 497 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +albendazole albendazole BRD-K79131256 3 2 HEPG2;PHH -0.0131638944149017 -0.04661527896920835 -0.1641071460076741 -0.2247803602367639 -0.3393371158412525 -0.3280250537874443 -0.8643842589864064 0.0 1 -0.0131638944149017 -0.0131638944149017 -0.3393371158412525 -0.3393371158412525 False False -0.7602171832806475 -0.6731742485694036 -1.9566576336916974 0.07723976046281375 455 520.0 535 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a95937159 BRD-A95937159 BRD-A95937159 3 2 HEPG2;PHH 0.0973812412056658 -0.051257243690391335 0.0231683403253555 -0.1006700377911329 -0.1388454176485538 -0.4660023937208785 -0.5984651302283128 0.0 1 0.0973812412056658 0.0973812412056658 -0.1388454176485538 -0.1388454176485538 False False -0.7652349588350349 -0.6818419628333875 -0.5127827924631215 0.7782568213034413 456 276.0 370 0 0 True 24242928 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +diltiazem diltiazem BRD-A69636825;BRD-K24023109;BRD-K81029756 7 2 HEPG2;PHH 0.1368611132105191 -0.060709817955891254 -0.2406801836831229 -0.0924175176769495 -0.2406801836831229 -0.4918829127850513 -0.5541619366729662 0.0 3 0.12914812647634086 0.28027981830139953 -0.3001571483910084 -0.16654885068003622 False False -0.7689638811215345 -0.6882833097094387 -1.5374502792710873 1.0042412072935074 457 374.0 472 0 1 True 198107 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +exemestane exemestane BRD-A73741725 3 2 HEPG2;PHH 0.3007753637826277 0.06692518446490997 -0.3872714276824678 0.0056125712580978 -0.3872714276824678 -0.5109991062402962 -0.5349684475370431 0.0 1 0.3007753637826277 0.3007753637826277 -0.3872714276824678 -0.3872714276824678 False False -0.7784833300088178 -0.7047272223578281 -2.057690859798236 2.4643560160150004 458 208.0 396 0 1 True 60198;73707497 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a11731846 BRD-A11731846 BRD-A11731846 12 3 HEPG2;HUH7;PHH -0.1082141109638744 -0.23083632149630123 -0.13431442741836816 0.09257258661091325 -0.15327684421624455 -0.4085389419702724 -0.7411887710969451 0.0 1 -0.1082141109638744 -0.1082141109638744 -0.15327684421624455 -0.15327684421624455 False False -0.779133327518745 -0.7058500291927062 -0.4428010366939694 -1.1140878043269455 459 464.0 493 0 0 True 16745401 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +phenolphthalein phenolphthalein BRD-K19227686 3 2 HEPG2;PHH 0.0067133924199475 -0.12108774959213203 -0.2612118457577058 0.1154062543064355 -0.2612118457577058 -0.5012152024603908 -0.5732796371670529 0.0 1 0.0067133924199475 0.0067133924199475 -0.2612118457577058 -0.2612118457577058 False False -0.7878550210439172 -0.7209158978340668 -1.030064118872716 -0.0269867437448949 460 417.0 500 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +naftidrofuryl naftidrofuryl BRD-A67862938 3 2 HEPG2;PHH 0.1088671750492519 0.005975251810418206 -0.2825357147625514 0.0028601121157407 -0.2825357147625514 -0.5038693500534883 -0.5687010720712207 0.0 1 0.1088671750492519 0.1088671750492519 -0.2825357147625514 -0.2825357147625514 False False -0.7882198860890987 -0.7215461663509165 -1.4848331382180646 1.0315780160054435 461 376.0 454 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +retinol retinol BRD-K13927029;BRD-K22429181 4 2 HEPG2;PHH 0.1615938018593523 -0.0012037480870882855 -0.1901199149766138 -0.0760950380936265 -0.19584221925054274 -0.46659677321209553 -0.6550244679711463 0.0 2 -0.13811667222115726 0.2533318205840057 -0.2094742371035473 -0.11564684938639404 True False -0.7941090071976686 -0.7317190444483531 -1.2227800164760274 1.3504154393345533 462 313.0 415 0 1 True 445354;9904001 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k16410418 BRD-K16410418 BRD-K16410418 17 3 HEPG2;HUH7;PHH -0.1044166671733061 -0.1980573038260142 0.0872476313795362 -0.0208797198720276 -0.2182785272598266 -0.4397163511446071 -0.7320482514111236 0.0 1 -0.1044166671733061 -0.1044166671733061 -0.2182785272598266 -0.2182785272598266 False False -0.8057404768501689 -0.7518112654585015 -0.28591394956654204 -0.9870024676172979 463 427.0 480 0 0 True 54646219 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +perindopril perindopril BRD-K92731339 3 2 HEPG2;PHH 0.0643361041115389 0.0487166641073094 -0.0871357300451823 -0.2706062477082014 -0.2706062477082014 -0.3956402773776697 -0.8205527770000377 0.0 1 0.0643361041115389 0.0643361041115389 -0.2706062477082014 -0.2706062477082014 False False -0.8059166658776886 -0.7521156146926268 -1.6876935420600718 0.8769980287453344 464 463.0 510 0 1 True 58153637 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +am-580 AM-580 BRD-K06854232 3 2 HEPG2;PHH -0.1793557786279254 -0.18121938490205336 0.159195819071361 -0.0837642382830381 -0.2632316574454307 -0.5349834282246847 -0.5456656638665923 0.0 1 -0.1793557786279254 -0.1793557786279254 -0.2632316574454307 -0.2632316574454307 False False -0.8078162601579808 -0.7553969771729939 -0.3738337238569759 -1.4194111750667517 465 483.0 535 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a46802340 BRD-A46802340 BRD-A46802340 12 3 HEPG2;HUH7;PHH 0.01808633691527775 -0.10034921925721896 -0.1761328657822949 -0.12237416021525854 -0.2711781077086925 -0.46892305936605205 -0.6869723338796387 0.0 1 0.01808633691527775 0.01808633691527775 -0.2711781077086925 -0.2711781077086925 False False -0.8124092263058714 -0.7633308749256061 -1.512071201187005 0.11148049148178543 466 465.0 504 0 0 True 4190864 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +aloisine aloisine BRD-K51276371;BRD-K93658967 3 2 HEPG2;PHH -0.1845970352490743 -0.25578757882532144 -0.1409642973116465 0.0328367166221141 -0.1409642973116465 -0.5198878797347701 -0.5888789356168773 0.0 2 -0.2206908498580257 -0.1845970352490743 -0.1409642973116465 -0.11751291448516506 False False -0.8143273475432088 -0.7666442409039593 -0.6097615298225718 -1.6865235778747292 467 522.0 529 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +phenacetin phenacetin BRD-K38323065 3 2 HEPG2;PHH -0.0659527646170722 -0.10413890538944134 -0.0458436320934976 -0.0593249928206205 -0.158299989067018 -0.4818468403425954 -0.6746431768738796 0.0 1 -0.0659527646170722 -0.0659527646170722 -0.158299989067018 -0.158299989067018 False False -0.8191684287795352 -0.7750067330940537 -0.6452702909271031 -0.44433625836851987 468 455.0 479 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +prostaglandin-a1 prostaglandin-a1 BRD-K04010869 3 2 HEPG2;PHH 0.1387025043368339 -0.14659015886071652 -0.1437215230294636 -0.0155271757394075 -0.1437215230294636 -0.4179065107471413 -0.8043338470826191 0.0 1 0.1387025043368339 0.1387025043368339 -0.1437215230294636 -0.1437215230294636 False False -0.8200734342884508 -0.7765700411921516 -0.7696449284435884 0.7475982186949741 469 275.0 356 0 1 True 5281912 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +spiperone spiperone BRD-K55468218 14 3 HEPG2;HUH7;PHH 0.11362403300073409 -0.07310412617193328 -0.3211609651999814 0.0211740769445896 -0.3211609651999814 -0.5079523998549178 -0.6424835748408758 0.0 1 0.11362403300073409 0.11362403300073409 -0.3211609651999814 -0.3211609651999814 False False -0.8291941872753557 -0.792325245845286 -1.644380266651381 0.8150738985979724 470 384.0 476 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +naltrexone naltrexone BRD-A66559694;BRD-K88172511 4 2 HEPG2;PHH 0.16098298329032126 0.09304955436123741 -0.24183929924454006 -0.13333881646394724 -0.2999035801206316 -0.481435741682256 -0.7051567439182056 0.0 2 0.1245243002971013 0.1974416662835412 -0.3359071633645466 -0.2638999968767166 False False -0.8340141136413588 -0.800651195075404 -1.8147791008248075 1.6412072630657457 471 370.0 481 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +genistein genistein BRD-A36151937;BRD-K43797669 22 2 HEPG2;PHH 0.09080567852490476 -0.20252204158653814 -0.23008756565728355 -0.114065789617598 -0.31573479206833455 -0.5252578205961203 -0.9175798975574296 0.045454545454545456 2 -0.17217374924156398 0.11826804052624434 -0.352231886770044 -0.022928617894649492 True False -0.9840477693748351 -0.8023100110131951 -1.762534580692514 0.26266492155039195 472 423.0 495 0 1 True 5280961;5284639 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +lumicolchicine lumicolchicine BRD-K99411983 3 2 HEPG2;PHH -0.0860692517211039 -0.16182722534156502 -0.1777952568871634 -0.1771145183593034 -0.1972291655838489 -0.5277965425011066 -0.6144005359586565 0.0 1 -0.0860692517211039 -0.0860692517211039 -0.1972291655838489 -0.1972291655838489 False False -0.8349968104804348 -0.8023487073130297 -1.4914856884335173 -0.7549464775671879 473 536.0 542 0 1 True 244898 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k34079378 BRD-K34079378 BRD-K34079378 12 3 HEPG2;HUH7;PHH -0.0520097940332359 -0.12788727817436052 -0.1779314907533781 -0.0131451012566685 -0.2124570491058485 -0.4820955304210887 -0.7061224860612243 0.0 1 -0.0520097940332359 -0.0520097940332359 -0.2124570491058485 -0.2124570491058485 False False -0.8351567734517009 -0.8026250276292184 -1.040660897150142 -0.4283516665362548 474 486.0 492 0 0 True 11052947 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +podophyllotoxin podophyllotoxin BRD-K47869605 14 3 HEPG2;HUH7;PHH -0.1558144746555222 -0.3268581066901485 -0.18422138211982592 0.1544526675716042 -0.21892781861658606 -0.392728741997705 -0.8899458684396767 0.0 1 -0.1558144746555222 -0.1558144746555222 -0.21892781861658606 -0.21892781861658606 False False -0.8377016762175433 -0.8070210971155581 -0.5749798743603657 -1.7224698605603461 475 497.0 535 0 1 True 10607;11892032;4865 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +isoxicam isoxicam BRD-A75552914 3 2 HEPG2;PHH 0.2815861085222827 0.1984847564405451 -0.3390571453741619 -0.0111062414944171 -0.3390571453741619 -0.4020813029732495 -0.8801799659425068 0.0 1 0.2815861085222827 0.2815861085222827 -0.3390571453741619 -0.3390571453741619 False False -0.842171285944503 -0.8147419087710207 -1.8401738532996124 2.7515567050389245 476 210.0 390 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ritanserin ritanserin BRD-K40887525 3 2 HEPG2;PHH -0.0894796904176473 -0.17299678725086975 -0.2466714339596884 0.0831375028938055 -0.2466714339596884 -0.3807519032427716 -0.9302485879614122 0.0 1 -0.0894796904176473 -0.0894796904176473 -0.2466714339596884 -0.2466714339596884 False False -0.8458761972234776 -0.8211417789907008 -1.0458610159547266 -0.8119505123134423 477 494.0 534 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +chlormadinone-acetate chlormadinone-acetate BRD-A01593789 3 2 HEPG2;PHH 0.3795388833516174 0.2407722214443816 -0.3221785681588309 -0.1558124963194131 -0.3221785681588309 -0.4739765779130042 -0.7719826615334207 0.0 1 0.3795388833516174 0.3795388833516174 -0.3221785681588309 -0.3221785681588309 False False -0.8599679086797145 -0.8454838259932558 -2.1791351794251677 3.5178223219142604 478 180.0 409 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a13346522 BRD-A13346522 BRD-A13346522 3 2 HEPG2;PHH -0.1608585864305496 -0.21013424793879187 -0.3614028053624289 0.0318373851478099 -0.3614028053624289 -0.4190047041527808 -0.8861646261472729 0.0 1 -0.1608585864305496 -0.1608585864305496 -0.3614028053624289 -0.3614028053624289 False False -0.8620870172264172 -0.8491443778011429 -1.8357684029029158 -1.3901046149969625 479 550.0 568 0 0 True 44629407 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +emf-bca1-57 EMF-BCA1-57 BRD-K64610608 3 2 HEPG2;PHH -0.2348800558182928 -0.23538334502114183 0.0646925089614731 -0.1198934316635131 -0.1721232682466507 -0.5438460678690009 -0.6642574605140243 0.0 1 -0.2348800558182928 -0.2348800558182928 -0.1721232682466507 -0.1721232682466507 False False -0.8759747981260131 -0.8731341548036748 -0.5312575657798404 -1.9481866276576332 480 535.0 558 0 1 True 44489675 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +syringic-acid syringic-acid BRD-K51980294 12 3 HEPG2;HUH7;PHH -0.06821099855005736 -0.18301389769961435 -0.07975109307361494 -0.0696485731750726 -0.20393418796759633 -0.49483761030234513 -0.7741251325951741 0.0 1 -0.06821099855005736 -0.06821099855005736 -0.20393418796759633 -0.20393418796759633 False False -0.8819001765999321 -0.8833696639373951 -0.8942595081239614 -0.705608305063089 481 483.0 486 0 0 True 10742 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +motesanib motesanib BRD-K99616396 3 2 HEPG2;PHH 0.1997996179593933 -0.09579474572092297 -0.2528245789664132 0.0880696037784218 -0.2528245789664132 -0.4045302375692815 -0.9553089882912379 0.0 1 0.1997996179593933 0.1997996179593933 -0.2528245789664132 -0.2528245789664132 False False -0.8821847317149005 -0.8838612049404089 -1.065254671655564 1.3019113620778104 482 199.0 352 0 1 True 11667893 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +flunisolide flunisolide BRD-A65449987;BRD-K49577446 5 2 HEPG2;PHH -0.0415877712269624 -0.0614055511024263 0.1040357095854623 -0.0606124941259622 -0.2383410249437604 -0.5208007432963877 -0.7290058830486876 0.0 2 -0.1220499963189165 -0.0415877712269624 -0.2383410249437604 -0.2042874949984252 False False -0.8853036848207315 -0.8892488899875151 -0.4058395556920221 -0.15299306155161355 483 364.0 463 0 1 True 13021033;5702174;82153 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +skf-96365 SKF-96365 BRD-A72703248 3 2 HEPG2;PHH 0.0232263854575446 0.012317633327458801 0.0168564873082297 -0.0950356684625148 -0.2514993259683251 -0.4713440228249907 -0.8372790038258591 0.0 1 0.0232263854575446 0.0232263854575446 -0.2514993259683251 -0.2514993259683251 False False -0.8899835247379202 -0.8973328536410725 -0.8030417744437799 0.4970785424191957 484 360.0 440 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +guanfacine guanfacine BRD-K32830106 3 2 HEPG2;PHH -0.0927111133933067 -0.13755000424053931 0.1323666902525084 -0.2277127496199682 -0.2277127496199682 -0.4513183828879384 -0.8775706023609797 0.0 1 -0.0927111133933067 -0.0927111133933067 -0.2277127496199682 -0.2277127496199682 False False -0.8901036840684282 -0.897540417078637 -0.7935031409619392 -0.7220188749034195 485 470.0 552 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +toremifene toremifene BRD-K51350053;BRD-K67174588 16 2 HEPG2;PHH 0.1280206543807354 -0.05416615030521315 -0.18110220240695135 0.00665558734908695 -0.21493622607418467 -0.4613673535826069 -0.8659000613108565 0.0 2 0.09129892993304464 0.1280206543807354 -0.2570408955216407 -0.21493622607418467 False False -0.8943173842380352 -0.9048191701173851 -0.9972880144280485 0.967482070365964 486 298.0 378 0 1 True 6536897 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +promazine promazine BRD-K06980535 4 2 HEPG2;PHH 0.1108552664518356 -0.0697315338895553 -0.34340591302939827 0.08633974660187956 -0.34340591302939827 -0.5255399530768277 -0.7403761592309271 0.0 1 0.1108552664518356 0.1108552664518356 -0.34340591302939827 -0.34340591302939827 False False -0.8957280326922912 -0.9072559267231545 -1.5729822801049678 0.8076989577326295 487 363.0 489 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +paroxetine paroxetine BRD-K37991163 3 2 HEPG2;PHH 0.0554083449145158 -0.08780693407687876 -0.3700864378895078 0.1403687559068203 -0.3700864378895078 -0.5338182459097532 -0.7262639718958073 0.0 1 0.0554083449145158 0.0554083449145158 -0.3700864378895078 -0.3700864378895078 False False -0.8969502318576569 -0.9093671556978754 -1.5594869427957898 0.3922790473442471 488 408.0 526 0 1 True 10947895;9951025 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +naloxone naloxone BRD-A41833852;BRD-A70461345 4 2 HEPG2;PHH 0.152347227351533 -0.02045155357983383 -0.1879249904304743 -0.11752963252365584 -0.30273640840979554 -0.5387791074989807 -0.719091531140582 0.0 2 -0.008364660044511169 0.152347227351533 -0.3443714246552969 -0.2811160463440631 True False -0.8983248730692717 -0.9117417133297638 -1.6135856660347088 1.2303734488164186 489 337.0 442 0 1 True 5353813;5702089 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +guggulsterone guggulsterone BRD-A59808129;BRD-A86109770 3 2 HEPG2;PHH 0.0668180779450469 0.011860983963641852 -0.1085739667926515 -0.14635746832937 -0.2312395833432674 -0.4922752846623697 -0.8133704287613491 0.0 2 0.011860983963641852 0.2591920652323299 -0.39764602083180633 -0.1085739667926515 False False -0.8989604990430442 -0.912839694747966 -1.2796142995239583 0.7778095273025999 490 409.0 471 0 1 True 21976524;73707425 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +oxantel oxantel BRD-K66019333 3 2 HEPG2;PHH -0.2957388899392552 -0.29947115356723464 -0.1321500028882707 0.0239624977111816 -0.1321500028882707 -0.548057646860206 -0.7029039417615249 0.0 1 -0.2957388899392552 -0.2957388899392552 -0.1321500028882707 -0.1321500028882707 False False -0.8995096177409685 -0.9137882433466488 -0.5873886323002391 -2.5425249398422256 491 553.0 562 0 1 True 51371405 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +altrenogest altrenogest BRD-A27554692 3 2 HEPG2;PHH -0.1753499905268351 -0.23588460497558114 -0.1748739246811185 0.136521827429533 -0.2295749932527542 -0.5779061550717978 -0.6488959231813038 0.0 1 -0.1753499905268351 -0.1753499905268351 -0.2295749932527542 -0.2295749932527542 False False -0.9023541166624497 -0.9187018357559488 -0.6278818819021799 -1.5644297250226662 492 512.0 540 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +epitestosterone epitestosterone BRD-A53131506;BRD-K25836724 5 2 HEPG2;PHH 0.1021685318814383 0.0324277724656793 -0.1314785757235118 -0.1375062335282564 -0.2792500002043588 -0.5994231367025465 -0.6279253490150922 0.0 2 0.0324277724656793 0.16153889480564326 -0.2898687426932156 -0.2792500002043588 False False -0.9133858112100927 -0.9377580042015283 -1.4444657908631937 1.0709406030420061 493 379.0 451 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +naproxol naproxol BRD-K34014345 3 2 HEPG2;PHH 0.1499888905220561 0.07586944186025191 -0.3469882091241223 -0.1828562472946941 -0.3469882091241223 -0.4169800458254205 -0.9947949362926124 0.0 1 0.1499888905220561 0.1499888905220561 -0.3469882091241223 -0.3469882091241223 False False -0.9143775139717267 -0.9394710732855236 -2.3976305288936697 1.5163200032580488 494 465.0 528 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +alfuzosin alfuzosin BRD-A09056319 3 2 HEPG2;PHH -0.0017555630248453 -0.045397222921666106 -0.4036000030381338 0.0518562421202659 -0.4036000030381338 -0.6024555818192542 -0.6304009957978176 0.0 1 -0.0017555630248453 -0.0017555630248453 -0.4036000030381338 -0.4036000030381338 False False -0.917656079718163 -0.9451344734870225 -2.0100362738776285 0.15489232711077955 495 507.0 547 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +zoxazolamine zoxazolamine BRD-K66353228 3 2 HEPG2;PHH 0.4441092014830146 0.430433773358042 -0.5585625001362392 -0.0518541955389082 -0.5585625001362392 -0.5953724569648444 -0.6471576767618812 0.0 1 0.4441092014830146 0.4441092014830146 -0.5585625001362392 -0.5585625001362392 False False -0.918951295345785 -0.9473718312262818 -3.179833731689703 4.528873876436749 496 182.0 450 2 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gw-1929 GW-1929 BRD-A15415227 3 2 HEPG2;PHH 0.2198833408248093 0.025844446435156793 -0.5316714282546725 0.2345312461256981 -0.5316714282546725 -0.5710845127154793 -0.7085133048461839 0.0 1 0.2198833408248093 0.2198833408248093 -0.5316714282546725 -0.5316714282546725 False False -0.9253411651385712 -0.9584097034761685 -2.174476985743405 1.8122943560081537 497 263.0 525 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +estradiol-cypionate estradiol-cypionate BRD-A91452556 3 2 HEPG2;PHH -0.1580763392978244 -0.3044273781383203 0.0099010648471968 -0.1610665125772357 -0.1610665125772357 -0.4752588320286974 -0.9030688197817653 0.0 1 -0.1580763392978244 -0.1580763392978244 -0.1610665125772357 -0.1610665125772357 False False -0.9267932419195801 -0.9609180234459896 -0.7898581730468042 -1.6669658288225726 498 517.0 551 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k60298771 BRD-K60298771 BRD-K60298771 12 3 HEPG2;HUH7;PHH -0.10506879000200159 -0.30487683994902504 0.007024414837360382 0.0320343063212931 -0.24451800881485852 -0.4650361101098714 -0.9326450306689367 0.0 1 -0.10506879000200159 -0.10506879000200159 -0.24451800881485852 -0.24451800881485852 False False -0.9313586254443398 -0.9688042749271895 -0.43469168723087814 -1.3252656911961207 499 440.0 450 0 0 True 54657895 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +piceatannol piceatannol BRD-K26241953;BRD-K91509126 4 2 HEPG2;PHH -0.12246456783678789 -0.2562877203648289 -0.19264689247523034 0.34383781440556044 -0.19264689247523034 -0.5660669241407295 -0.735099315355044 0.0 2 -0.3568747252639797 -0.12052904532497949 -0.2804130017757416 -0.19264689247523034 False False -0.9336165818182515 -0.9727046727145108 0.033248655366754865 -1.2859184272277173 500 397.0 527 0 1 True 4813 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cycloheximide cycloheximide BRD-A62184259;BRD-A82329351;BRD-K36055864 20 3 HEPG2;HUH7;PHH 0.06325733206338345 -0.06802238027254733 0.25203992426395416 -0.2703135209158063 -0.29763902830226074 -0.4255216025584747 -1.020655456516478 0.0 3 0.010351785976025749 0.2406808361411094 -0.3997360840439796 -0.0419152546674013 False False -0.9358493308167137 -0.976561527237417 -0.7420033468827236 0.5049532761112026 501 282.0 511 0 1 True 6610302 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k71726959 BRD-K71726959 BRD-K71726959 3 2 HEPG2;PHH -0.3533555530011654 -0.5538619435909722 0.1651885764939444 0.1894456809386611 -0.0441557578742504 -0.2788644434721579 -1.314586787769157 0.0 1 -0.3533555530011654 -0.3533555530011654 -0.0441557578742504 -0.0441557578742504 False False -0.9361578373567364 -0.9770944419739378 1.0213773275804408 -3.7109860117569013 502 499.0 557 0 0 True 6610355 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ftase-inhibitor-b581 FTase-inhibitor-B581 BRD-K04877770 3 2 HEPG2;PHH 0.2191050859789053 0.05589876675771341 -0.2926325798034668 0.2911922093480825 -0.3602900858968496 -0.6186163888889409 -0.6736032457297875 0.0 1 0.2191050859789053 0.2191050859789053 -0.3602900858968496 -0.3602900858968496 False False -0.9554180117538347 -1.010364500895281 -0.8519771865575494 1.9012416727474462 503 118.0 369 1 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +carvedilol carvedilol BRD-A10977446 3 2 HEPG2;PHH -0.0893361245592435 -0.1723849225996269 0.0359310486486979 -0.2004173835739493 -0.20393125154078 -0.63830296346356 -0.6507130455307012 0.0 1 -0.0893361245592435 -0.0893361245592435 -0.20393125154078 -0.20393125154078 False False -0.9636594862289105 -1.024600838310057 -0.939354253264152 -0.8091078425580647 504 496.0 544 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a84238007 BRD-A84238007 BRD-A84238007 12 3 HEPG2;HUH7;PHH -0.0444085844792425 -0.12667157107757193 -0.23496081254311965 -0.0160968541167676 -0.30007625690528317 -0.5353881206866058 -0.8600458918704785 0.0 1 -0.0444085844792425 -0.0444085844792425 -0.30007625690528317 -0.30007625690528317 False False -0.9654110666218451 -1.0276265213426667 -1.4441573770599638 -0.3753490696971283 505 498.0 511 0 0 True 3122973 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +su-4312 SU-4312 BRD-K20287671;BRD-K60487568 3 2 HEPG2;PHH 0.0690623737043804 0.022761385887861252 0.1202214317662375 -0.3437062427401542 -0.3437062427401542 -0.4783962092229298 -0.9773165605045737 0.0 2 -0.0235396019286579 0.10898396703932015 -0.5021032568599496 0.2555706035345793 True True -0.9670544894752167 -1.03046537285237 -1.4733577604465795 0.8264236796015172 506 393.0 540 0 1 True 5353593;6450842 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +carbinoxamine carbinoxamine BRD-A29426959 3 2 HEPG2;PHH 0.2492361217737198 0.0567513919538922 -0.3630285688808986 0.0377562455832958 -0.3630285688808986 -0.4579428931964295 -1.0209727832337931 0.0 1 0.2492361217737198 0.2492361217737198 -0.3630285688808986 -0.3630285688808986 False False -0.968429284813326 -1.0328401967226346 -1.827093641164462 2.098939237890777 507 245.0 405 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sb-225002 SB-225002 BRD-K61323504 3 2 HEPG2;PHH -0.252458273122708 -0.2622856264933944 -0.1428217132176671 0.0069170221686363 -0.1428217132176671 -0.5542978952150969 -0.8356514000777331 0.0 1 -0.252458273122708 -0.252458273122708 -0.1428217132176671 -0.1428217132176671 False False -0.9721235952539634 -1.0392217550356402 -0.697554760702164 -2.14609422616521 508 545.0 555 0 1 True 3854666 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tadalafil tadalafil BRD-K93645900 3 2 HEPG2;PHH -0.133861114581426 -0.234663888398144 -0.3128214201756886 0.0003250120207667 -0.3128214201756886 -0.6309823978339814 -0.6951619233782005 0.0 1 -0.133861114581426 -0.133861114581426 -0.3128214201756886 -0.3128214201756886 False False -0.9785633595230816 -1.050345815091161 -1.660440663605983 -1.2920643901182323 509 544.0 555 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tyrphostin-ag-527 tyrphostin-AG-527 BRD-K43405658 12 3 HEPG2;HUH7;PHH 1.8259924319049756e-05 -0.07339145408736328 -0.049400977790355655 -0.20231733098626137 -0.22575767431408167 -0.572116563894919 -0.8137649750218741 0.0 1 1.8259924319049756e-05 1.8259924319049756e-05 -0.22575767431408167 -0.22575767431408167 False False -0.9789990514058561 -1.051098430011078 -1.2559826350105538 0.07883132994631656 510 470.0 508 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +e-4031 E-4031 BRD-K41713976 4 2 HEPG2;PHH 0.04669237198928994 -0.18436917978235415 -0.26808012010795723 0.03750528581440445 -0.3383604175012026 -0.5913409853265399 -0.815677517522422 0.0 1 0.04669237198928994 0.04669237198928994 -0.3383604175012026 -0.3383604175012026 False False -0.9991797440877509 -1.0859585938266931 -1.480875994850211 0.03389660314172227 511 420.0 484 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +betamethasone betamethasone BRD-A02180903;BRD-K39188321 5 2 HEPG2;PHH 0.1441527787182066 -0.0254222179452578 -0.0862289730991636 -0.1520348433405161 -0.4951687548309564 -0.5870823408255265 -0.8289704497253139 0.0 2 0.1441527787182066 0.22623336356547144 -0.4951687548309564 -0.4431984658752169 False False -1.0015675656881835 -1.0900833210333178 -1.905068632805298 1.1617885855241312 512 314.0 407 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +hypericin hypericin BRD-K29673530 3 2 HEPG2;PHH -0.2022472305430306 -0.3149315923866298 -0.30867857166699 -0.1267999904230237 -0.30867857166699 -0.295340066716548 -1.4185919983992499 0.0 1 -0.2022472305430306 -0.2022472305430306 -0.30867857166699 -0.30867857166699 False False -1.004636065916173 -1.0953838536910465 -2.0175014170676877 -1.985722249576459 513 564.0 569 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tramadol tramadol BRD-K04412738;BRD-K51033547 3 2 HEPG2;PHH -0.0248749959799978 -0.1172402756185167 -0.3513642868825367 -0.0820374824106693 -0.3513642868825367 -0.5778231930638116 -0.8638380247996085 0.0 2 -0.2096055552570356 0.0769611137608687 -0.4496142800365175 -0.30884776557130467 True False -1.0097422054636158 -1.104204208071099 -2.12050741118351 -0.21941943740287742 514 530.0 547 0 1 True 33741;667511 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +lupanine lupanine BRD-A92826379 3 2 HEPG2;PHH -0.0223694410589006 -0.1267666636655728 0.2314785655055727 -0.3222000077366829 -0.3222000077366829 -0.55103017377948 -0.9228285308631641 0.0 1 -0.0223694410589006 -0.0223694410589006 -0.3222000077366829 -0.3222000077366829 False False -1.012444439211062 -1.108872051370084 -1.0214304999742205 -0.23299213199780955 515 418.0 557 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +ruxolitinib ruxolitinib BRD-K53972329 4 2 HEPG2;PHH 0.06580974792854649 -0.004601769201043604 -0.08512222500784056 -0.0744569280650466 -0.2649792597762176 -0.4877883406163799 -1.0519273198461012 0.0 1 0.06580974792854649 0.06580974792854649 -0.2649792597762176 -0.2649792597762176 False False -1.0137520005394305 -1.1111307350943935 -1.0808800019545501 0.7198011138339669 516 359.0 404 0 1 True 25126798 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +l-161982 L-161982 BRD-K39733634 3 2 HEPG2;PHH 0.2234972160723474 0.024926386954676805 -0.4432214285646166 -0.2077875006943941 -0.4432214285646166 -0.6580858985405591 -0.712462644972321 0.0 1 0.2234972160723474 0.2234972160723474 -0.4432214285646166 -0.4432214285646166 False False -1.0143172210267197 -1.112107097952172 -3.0060770688714387 1.8328152171910421 517 453.0 537 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +zolmitriptan zolmitriptan BRD-K54314721 3 2 HEPG2;PHH -0.0170944395164648 -0.14112222049799225 -0.2290285655430385 -0.2038062484934926 -0.2290285655430385 -0.5770546948492882 -0.880884241382961 0.0 1 -0.0170944395164648 -0.0170944395164648 -0.2290285655430385 -0.2290285655430385 False False -1.0174968155407687 -1.1175995350738384 -1.8058072019125047 -0.24374043703181264 518 514.0 545 0 1 True 60857 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +emetine emetine BRD-A25687296;BRD-K01976263;BRD-K03067624 16 3 HEPG2;HUH7;PHH 0.33049882720741963 -0.06417793718477086 0.508589397583689 -0.5738870147615671 -0.5738870147615671 -0.6244435055506607 -1.2036680389373076 0.0625 3 0.0470157998303572 0.3828164661924044 -0.8298229351639748 -0.110780319198966 False False -1.2262775250193145 -1.1241720206277008 -1.5893852586779356 2.24676822917739 519 71.0 524 2 1 True 10219;11957493 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +minoxidil minoxidil BRD-K06902185;BRD-K14888893 3 2 HEPG2;PHH 0.2662107050418854 0.10373253706428745 -0.3361863068171909 -0.1992936888709664 -0.3411008352413773 -0.6521586738822479 -0.741695458198794 0.0 2 -0.0587456309133105 0.2778066727850172 -0.42334016306059696 -0.3411008352413773 True False -1.023006402981645 -1.127116806050256 -2.3994149258864117 2.355729546832669 520 345.0 500 0 1 True 4201 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +d-64131 D-64131 BRD-K26997899 14 3 HEPG2;HUH7;PHH -0.1774373904077543 -0.23382595579864246 -0.18568675060357365 0.14422184228897095 -0.18568675060357365 -0.4532830431273887 -1.1509986098242244 0.0 1 -0.1774373904077543 -0.1774373904077543 -0.18568675060357365 -0.18568675060357365 False False -1.0287823480395009 -1.1370941836398514 -0.5248963517308592 -1.5715032513809324 521 514.0 542 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +oxibendazole oxibendazole BRD-K52075715 3 2 HEPG2;PHH 0.1047434348406063 -0.11365883849147293 -0.3830571493932179 0.0064325761049985 -0.3830571493932179 -0.5517504011975631 -0.9634468746223739 0.0 1 0.1047434348406063 0.1047434348406063 -0.3830571493932179 -0.3830571493932179 False False -1.03347383850875 -1.1451982724774041 -2.0318580970324804 0.6307706019153347 522 438.0 510 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +physostigmine physostigmine BRD-K25650355 3 2 HEPG2;PHH -0.1896611087852054 -0.5210458259615633 0.0299785818372453 0.252495382912457 0.0299785818372453 -0.6294006254997045 -0.8086586606740538 0.0 1 -0.1896611087852054 -0.1896611087852054 0.0299785818372453 0.0299785818372453 False False -1.0337299558367314 -1.1456406899974656 0.9953293264503613 -2.5488081395254953 523 400.0 483 0 1 True 16212981 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dmbi DMBI BRD-K96084870 3 2 HEPG2;PHH -0.2077490941931804 -0.5788258859473798 0.0334469888891492 -0.1849751770496368 -0.2412142548710107 -0.6153285851081212 -0.8417505294468903 0.0 1 -0.2077490941931804 -0.2077490941931804 -0.2412142548710107 -0.2412142548710107 False False -1.0362038498315664 -1.1499140988086403 -0.9960067117369074 -2.8465752197775567 524 536.0 561 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +immethridine immethridine BRD-K49519092 3 2 HEPG2;PHH -0.051741717577291 -0.06996807786506701 -0.2380880330290113 -0.0192687362432479 -0.2973665408790111 -0.6799673237616107 -0.7227430698057149 0.0 1 -0.051741717577291 -0.051741717577291 -0.2973665408790111 -0.2973665408790111 False False -1.041338858664468 -1.1587843220428595 -1.4560558057278548 -0.2454936449366384 525 509.0 516 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +praziquantel praziquantel BRD-A21858158 3 2 HEPG2;PHH -0.1401444483134481 -0.2122111149753133 -0.0585857209350381 -0.2582166865468025 -0.2582166865468025 -0.5086518927580781 -1.0656719780009654 0.0 1 -0.1401444483134481 -0.1401444483134481 -0.2582166865468025 -0.2582166865468025 False False -1.0414878817585609 -1.1590417447960957 -1.53360326277476 -1.262521465200917 526 546.0 563 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +alclometasone alclometasone BRD-A90131694 3 2 HEPG2;PHH 0.483069437659449 0.34066388321419555 -0.329071432352066 -0.2721360512077808 -0.3823500052094459 -0.6487345406933436 -0.7974274646165588 0.0 1 0.483069437659449 0.483069437659449 -0.3823500052094459 -0.3823500052094459 False False -1.047448273001623 -1.1693377350484377 -2.7014492826555605 4.500329379503254 527 151.0 421 1 1 True 73707510 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pentamidine pentamidine BRD-K13183738 12 3 HEPG2;HUH7;PHH -0.260883184046381 -0.3479320408465961 -0.33294928073883057 0.33245052583515644 -0.33294928073883057 -0.5619405290002875 -0.998870512995396 0.0 1 -0.260883184046381 -0.260883184046381 -0.33294928073883057 -0.33294928073883057 False False -1.0613757854979855 -1.1933961444806773 -0.7792086506902252 -2.4684571007183 528 534.0 571 0 0 True 359323 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +bisacodyl bisacodyl BRD-K39987650 3 2 HEPG2;PHH 0.1486583413142297 0.1144361220196717 -0.1918857051059603 -0.3285499950870871 -0.4181809978825705 -0.6541217999858042 -0.8354906577520841 0.0 1 0.1486583413142297 0.1486583413142297 -0.4181809978825705 -0.4181809978825705 False False -1.0718671288618462 -1.211518909346829 -2.5516548179549465 1.628311988796579 529 461.0 526 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a94546435 BRD-A94546435 BRD-A94546435 12 3 HEPG2;HUH7;PHH 0.0015272766144739502 -0.18370223624838716 -0.2774981614202261 0.0447447448968887 -0.325254712253809 -0.565748195104774 -1.03034772554649 0.0 1 0.0015272766144739502 0.0015272766144739502 -0.325254712253809 -0.325254712253809 False False -1.080922057878019 -1.2271604095578572 -1.453857015812271 -0.25636103254295084 530 464.0 508 0 0 True 23786410 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +etamivan etamivan BRD-K38055836 3 2 HEPG2;PHH 0.0295599134018023 0.01062717816481985 -0.2768588938883373 -0.1856249962002039 -0.2960937581956386 -0.7261002202119147 -0.7288502023244898 0.0 1 0.0295599134018023 0.0295599134018023 -0.2960937581956386 -0.2960937581956386 False False -1.0905253213741597 -1.2437491037080992 -2.066035825562092 0.5327876823779463 531 498.0 538 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dexamethasone-acetate dexamethasone-acetate BRD-A93424738 3 2 HEPG2;PHH 0.017825084634953 -0.07053703100730975 -0.2943499269230025 0.035935241729021 -0.2943499269230025 -0.729631379631067 -0.7305959837755098 0.0 1 0.017825084634953 0.017825084634953 -0.2943499269230025 -0.2943499269230025 False False -1.094929371518822 -1.2513566676264998 -1.451500254975668 0.2030170603079687 532 460.0 509 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tebuthiuron tebuthiuron BRD-K34820100 3 2 HEPG2;PHH 0.3052361069454087 0.22886110511091015 -0.1143214298146111 -0.5528499949723482 -0.5528499949723482 -0.6959496077209238 -0.8856400727176124 0.0 1 0.3052361069454087 0.3052361069454087 -0.5528499949723482 -0.5528499949723482 False False -1.13876964407973 -1.3270864310833097 -3.334888605457591 2.9996295236635775 533 372.0 527 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-k98803880 BRD-K98803880 BRD-K98803880 12 3 HEPG2;HUH7;PHH -0.09119467395875186 -0.2052251567236251 -0.2388611781810011 -0.11027248483151195 -0.29465728159993887 -0.706041843260801 -0.8950101837759749 0.0 1 -0.09119467395875186 -0.09119467395875186 -0.29465728159993887 -0.29465728159993887 False False -1.1535469351487884 -1.3526127495074816 -1.7234950114965832 -0.9238345955693048 534 531.0 541 0 0 True 54618470 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mesoridazine mesoridazine BRD-A14395271 3 2 HEPG2;PHH -0.0605259049269888 -0.20680338434047169 -0.1070924635444368 -0.3599655125290155 -0.3823356879875064 -0.8026058943794361 -0.8054967558026196 0.0 1 -0.0605259049269888 -0.0605259049269888 -0.3823356879875064 -0.3823356879875064 False False -1.2053542722807458 -1.4421048342311695 -2.3003668100576373 -0.7302580816548048 535 547.0 565 0 1 True 4078 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +prednisolone prednisolone BRD-A27887842 3 2 HEPG2;PHH -0.0853888992634084 -0.3246375064676006 -0.196328580379486 0.1420624973252415 -0.2468437533825636 -0.7939738202100945 -0.8397429229891193 0.0 1 -0.0853888992634084 -0.0853888992634084 -0.2468437533825636 -0.2468437533825636 False False -1.2138452817046543 -1.4567722187527592 -0.7196408805820529 -1.259677123789274 536 442.0 514 0 1 True 7048968;7061270 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sildenafil sildenafil BRD-K50128260;BRD-K79759585 4 2 HEPG2;PHH -0.07646152749657631 -0.33609790955152774 -0.3378935786230223 -0.02211042679846284 -0.34043814887159635 -0.6287851811918829 -1.2057775621161988 0.0 2 -0.2325861048367288 0.0796630498435762 -0.379157236777246 -0.3017190609659467 True False -1.2316739622499822 -1.487569512692228 -1.8731262171559964 -1.2377308562794962 537 532.0 550 0 1 True 5212 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +triciribine triciribine BRD-A11706664;BRD-A42649439;BRD-K80431395 6 2 HEPG2;PHH -0.1453994326293468 -0.20943316527538824 -0.3507539523499352 0.23564652819186443 -0.3507539523499352 -0.811211874388853 -0.8470098598451825 0.0 3 -0.238472882244322 -0.1187322007285224 -0.600607190813337 -0.1964464304702622 False False -1.2347168043114443 -1.4928257233882452 -1.1673909079737879 -1.287848666739432 538 502.0 564 0 1 True 16759157 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mephentermine mephentermine BRD-K18194590 3 2 HEPG2;PHH 0.16676667249865 -0.08161388648053011 0.0562285568032945 -0.3083625137805938 -0.3083625137805938 -0.8121858713039682 -0.8453669625607925 0.0 1 0.16676667249865 0.16676667249865 -0.3083625137805938 -0.3083625137805938 False False -1.2348693525843646 -1.4930892355415502 -1.468576014282212 1.1324425706658556 539 299.0 490 0 1 True 73707340 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +scopolamine scopolamine BRD-A14566392;BRD-A62035778;BRD-K89923877 5 2 HEPG2;PHH -0.0229471752213107 -0.0934997409996059 -0.194011207137789 -0.0850937515497207 -0.4036164092166083 -0.8050423689511796 -0.912576255935525 0.0 3 -0.0971978588236702 0.16030555725511575 -0.4692390374839306 0.007070981697844592 True True -1.261330496918942 -1.5387982625205685 -1.7929213627126088 -0.13270055735040187 540 481.0 514 0 1 True 23581798;2837667;5702114;73707515 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cyclopentolate cyclopentolate BRD-A77291778 3 2 HEPG2;PHH -0.0475444430485367 -0.0605724106749726 -0.4096428709370749 -0.1508111590519547 -0.4096428709370749 -0.7146239293340061 -1.1157254329032547 0.0 1 -0.0475444430485367 -0.0475444430485367 -0.4096428709370749 -0.4096428709370749 False False -1.2724866457856334 -1.5580694135744249 -2.6494459225590883 -0.18894386205319444 541 557.0 560 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fluperlapine fluperlapine BRD-K15715913 3 2 HEPG2;PHH 0.1082556504342291 -0.0023016662647326463 -0.372081526688167 -0.2864274447783828 -0.372081526688167 -0.688366114841922 -1.168936127408718 0.0 1 0.1082556504342291 0.1082556504342291 -0.372081526688167 -0.372081526688167 False False -1.272834178546281 -1.558669742272673 -2.8464819105933596 1.00173647951621 542 503.0 555 0 1 True 49381 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +emd-386088 EMD-386088 BRD-K47659338 3 2 HEPG2;PHH 0.2422166599167717 -0.0015375018119812012 -0.5859071569783347 -0.2663812395185232 -0.5859071569783347 -0.7295490671540539 -1.1399228322053596 0.0 1 0.2422166599167717 0.2422166599167717 -0.5859071569783347 -0.5859071569783347 False False -1.2995104832567337 -1.60475043766109 -3.97288318751327 1.8712249589881726 543 510.0 561 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +resveratrol resveratrol BRD-K25591257;BRD-K80738081 4 2 HEPG2;PHH 0.016945831891563252 -0.1076958315033051 -0.3431392929383686 0.0256687989458442 -0.3431392929383686 -0.6974358829920961 -1.231505506483483 0.0 2 -0.1600250016070074 0.1010332813279496 -0.43191071067537573 -0.17886070907115936 True False -1.3131886362338376 -1.6283781030238687 -1.752881500871463 0.081124205114453 544 484.0 530 0 1 True 445154 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +mexiletine mexiletine BRD-A64092382 3 2 HEPG2;PHH 0.3525027715497547 0.29108888573116726 -0.4921642893127033 -0.1531687583774328 -0.4921642893127033 -0.8312379579015431 -0.9701527614970618 0.0 1 0.3525027715497547 0.3525027715497547 -0.4921642893127033 -0.4921642893127033 False False -1.316314338650074 -1.6337774468415671 -3.114332813105232 3.500172235953168 545 311.0 508 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +salsolinol salsolinol BRD-K99595596 3 2 HEPG2;PHH -0.2921791867249542 -0.2940534860309627 -0.2086571521524872 -0.1532208360731601 -0.2086571521524872 -0.7898525076785258 -1.0707487766113546 0.0 1 -0.2921791867249542 -0.2921791867249542 -0.2086571521524872 -0.2086571521524872 False False -1.325226895984203 -1.6491730139601597 -1.5415568420590966 -2.5025418658407363 546 566.0 572 0 1 True 54456 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +purmorphamine purmorphamine BRD-K73397362 3 2 HEPG2;PHH 0.1701965260112451 0.0653940030735814 -0.2000828140548297 -0.3068822938948869 -0.438044935464859 -0.8479958405526029 -0.9584676891469234 0.0 1 0.1701965260112451 0.1701965260112451 -0.438044935464859 -0.438044935464859 False False -1.3272296851260645 -1.6526326354247918 -2.5622072901855715 1.6143609687752318 547 437.0 521 0 1 True 5284329 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +t-0901317 T-0901317 BRD-K23383398 3 2 HEPG2;PHH -0.0882472230328453 -0.10532562186320615 -0.6888029351830482 0.1003374960273504 -0.6888029351830482 -0.7415837499623497 -1.172509699586838 0.0 1 -0.0882472230328453 -0.0882472230328453 -0.6888029351830482 -0.6888029351830482 False False -1.3278385997557687 -1.6536844756205573 -3.4474395712444474 -0.5923542181754299 548 564.0 573 0 1 True 447912 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +protein-tyrosine-phosphatase-inhibitor-iv protein-tyrosine-phosphatase-inhibitor-IV BRD-K02581333 3 2 HEPG2;PHH -0.0796055619915326 -0.13153749642272783 -0.1921785729272025 -0.3795687519013881 -0.4475000245230539 -0.8242073513212658 -1.0462306035859954 0.0 1 -0.0796055619915326 -0.0796055619915326 -0.4475000245230539 -0.4475000245230539 False False -1.3473226531142635 -1.6873412634511693 -2.7800681373941725 -0.6183875575340938 549 562.0 570 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a37656721 BRD-A37656721 BRD-A37656721 3 2 HEPG2;PHH -0.1372937824991014 -0.1659906796283192 -0.2197884981121335 -0.3141440395265817 -0.347792848944664 -0.8754761106083317 -0.9781500944971211 0.0 1 -0.1372937824991014 -0.1372937824991014 -0.347792848944664 -0.347792848944664 False False -1.3645511578568923 -1.717101812659917 -2.4119107594778226 -1.0995308903635526 550 566.0 570 0 0 True 44629413 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +metolazone metolazone BRD-A61793559 3 2 HEPG2;PHH 0.0401295075813929 -0.006277037577496598 -0.5590485547270093 -0.0747184865176677 -0.5590485547270093 -0.8172481072889196 -1.1110618103310348 0.0 1 0.0401295075813929 0.0401295075813929 -0.5590485547270093 -0.5590485547270093 False False -1.372779012454437 -1.7313146230744374 -3.2508842224274406 0.548339984288191 551 542.0 567 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +sb-239063 SB-239063 BRD-K82091397;BRD-K98143437 3 2 HEPG2;PHH -0.1411764670370353 -0.2011506467954152 0.2343312725424766 -0.0290910573676228 -0.3310896349804742 -0.7987904160889605 -1.1787183498298484 0.0 2 -0.2611248265537951 0.003302041906863451 -0.6660167056002787 -0.0290910573676228 True False -1.3881495910038848 -1.7578657873293315 -0.15938492360179723 -1.234613589817035 552 388.0 502 0 1 True 5166 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +cgp-57380 CGP-57380 BRD-K42500029 3 2 HEPG2;PHH 0.2280615402592553 -0.1262983965377013 -0.4609647691249847 -0.243197632022202 -0.4609647691249847 -0.8154668140018152 -1.1461820606962734 0.0 1 0.2280615402592553 0.2280615402592553 -0.4609647691249847 -0.4609647691249847 False False -1.3885578443499518 -1.758571004872976 -3.210379395987817 1.3894543752785515 553 468.0 549 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +nocodazole nocodazole BRD-K12539581 3 2 HEPG2;PHH -0.1034083275331391 -0.11674582358035776 -0.1427357069083622 -0.2720250049605965 -0.2720250049605965 -0.7455011830029507 -1.291221394861442 0.0 1 -0.1034083275331391 -0.1034083275331391 -0.2720250049605965 -0.2720250049605965 False False -1.3911118804336717 -1.7629828512685828 -1.8617835490547185 -0.7262014025072091 554 552.0 560 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dexamethasone dexamethasone BRD-A10188456;BRD-A35108200;BRD-A69951442;BRD-K38775274;BRD-K47635719 11 2 HEPG2;PHH -0.0744517939165234 -0.16416951600048274 -0.3882809983832495 -0.0694562643766403 -0.4137044016804014 -0.6799109381963573 -1.4882487522157293 0.0 5 -0.16153125382132 0.2011010092165735 -0.5754535517522267 -0.07918104492793121 True False -1.424035314304222 -1.8198548484884618 -2.3527613744658114 -0.6870740709246006 555 552.0 559 0 1 True 3003;40469526;40469540;5743;73707402 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +fludroxycortide fludroxycortide BRD-A49765801;BRD-K00824317 4 2 HEPG2;PHH 0.033425480851696596 -0.1210943717095587 -0.34468213681663784 -0.0749584080185741 -0.3545428461262158 -0.8605089869704985 -1.1691644362114844 0.0 2 -0.08065833399693174 0.033425480851696596 -0.4624111610132137 -0.3545428461262158 True False -1.4450912050762406 -1.856226831014849 -2.087500212843999 0.14589375419034065 556 506.0 531 0 1 True 15209;5702172 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +5-methoxytryptamine 5-methoxytryptamine BRD-K30197592 3 2 HEPG2;PHH -0.270496033752958 -0.29095841106027365 -0.203335838658469 -0.1620442010462284 -0.4307967498898506 -0.9048317415078008 -1.089756974492163 0.0 1 -0.270496033752958 -0.270496033752958 -0.4307967498898506 -0.4307967498898506 False False -1.4497102287538821 -1.8642057405899028 -2.1203874785351715 -2.352512996074232 557 565.0 571 0 1 True 1833 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +coumarin coumarin BRD-K23913458 3 2 HEPG2;PHH -0.0132916718721389 -0.0215847647438446 -0.4201499926192419 -0.0342500060796737 -0.4201499926192419 -0.8707166601504598 -1.1817214276700738 0.0 1 -0.0132916718721389 -0.0132916718721389 -0.4201499926192419 -0.4201499926192419 False False -1.4615773739854967 -1.8847050680073867 -2.3592760129916943 0.15468720339633046 558 529.0 554 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +noscapine noscapine BRD-A51393488;BRD-K91301684 3 2 HEPG2;PHH -0.0839574055539237 -0.1148689786593119 -0.3832179563386099 -0.1933208331465721 -0.3832179563386099 -0.9326015662934098 -1.1196249737662987 0.0 2 -0.1148689786593119 -0.0497072450816631 -0.3832179563386099 -0.3700711226889065 False False -1.4924140531765593 -1.937972401546162 -2.629921858077987 -0.5944308555546773 559 560.0 568 0 1 True 12310313;262535;275196;31411 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +homoharringtonine homoharringtonine BRD-A24643465;BRD-K76674262 14 3 HEPG2;HUH7;PHH 0.36148894578218455 0.165614319861763 0.3700893436159406 -0.9163999417796731 -0.9163999417796731 -1.10862615855322 -1.7170212112721943 0.14285714285714285 2 0.336399710840649 0.6739796996116638 -1.1962175965309143 -0.8405229728668928 False False -1.9671367641893172 -1.948693409340636 -3.9037401203633304 3.165958160066523 560 242.0 575 2 1 True 16219462;285033 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gw-3965 GW-3965 BRD-K33818169 3 2 HEPG2;PHH -0.089851852092478 -0.18555093184113503 -0.3218369377510888 0.3235937505960464 -0.3218369377510888 -0.8717140710897863 -1.26323450220904 0.0 1 -0.089851852092478 -0.089851852092478 -0.3218369377510888 -0.3218369377510888 False False -1.5033313221943063 -1.9568309111313775 -0.7440337550057127 -0.8536182952892805 561 437.0 549 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +dicycloverine dicycloverine BRD-K68507560 3 2 HEPG2;PHH -0.3067978198329608 -0.3700747953520881 -0.6431946254202298 -0.1885486245155334 -0.6431946254202298 -0.9021449280636652 -1.3937897792396445 0.0 1 -0.3067978198329608 -0.3067978198329608 -0.6431946254202298 -0.6431946254202298 False False -1.5990398176834875 -2.1221579335428626 -4.058036926486894 -2.834896000277678 562 575.0 575 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +vinorelbine vinorelbine BRD-K10916986;BRD-M30523314 4 2 HEPG2;PHH 0.05252192210819985 -0.0348909574871262 -0.38680128966058996 -0.28734624409116805 -0.602891240668084 -1.0270017239316884 -1.185936952841335 0.0 2 -0.08403309579524729 0.2958153076469898 -0.7589623481035233 -0.34900203184224665 True False -1.619970200352356 -2.1583131131524738 -3.483778332374193 0.5390728206385852 563 533.0 562 0 1 True 13200033;73707409;73707424 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +azaperone azaperone BRD-K45861246 3 2 HEPG2;PHH -0.0950055617011255 -0.16223334117482102 -0.4841285816260746 -0.2124812453985214 -0.4841285816260746 -1.0187812460630776 -1.2047494355596542 0.0 1 -0.0950055617011255 -0.0950055617011255 -0.4841285816260746 -0.4841285816260746 False False -1.6211559638429047 -2.1603614030788245 -3.2470670247603786 -0.8140591480165109 564 570.0 572 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +finasteride finasteride BRD-A83081521;BRD-K01095011 4 2 HEPG2;PHH -0.23592823826604414 -0.4664770596557193 -0.16483539928283006 -0.09389374777674676 -0.22909621867750365 -0.964836676856355 -1.4934758716780279 0.0 2 -0.2617879120839966 -0.1875250012510353 -0.3932249865361622 -0.22809265208031446 False False -1.7115746126953688 -2.316550735163115 -1.2854837641176835 -2.677639161696031 565 552.0 561 0 1 True 10970751;11865433;57363 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +3,3'-diindolylmethane 3,3'-diindolylmethane BRD-K37846922 4 2 HEPG2;PHH 0.09771548511667374 0.032708990853279774 -0.5248960682324 0.03316847828682514 -0.5248960682324 -1.0174029348981717 -1.4064579213514836 0.0 1 0.09771548511667374 0.09771548511667374 -0.5248960682324 -0.5248960682324 False False -1.7206318955739135 -2.332196301440119 -2.738869307226835 1.0429964711949122 566 487.0 552 0 1 True 3071 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +primaquine primaquine BRD-A55913614 3 2 HEPG2;PHH -0.0808057222101423 -0.2828639715702997 -0.0761714194502149 -0.2878268491476774 -0.2878268491476774 -0.7827883954677317 -2.1239481312148865 0.0 1 -0.0808057222101423 -0.0808057222101423 -0.2878268491476774 -0.2878268491476774 False False -1.844762461075175 -2.546619657273742 -1.7504572200730317 -1.0993785880071565 567 536.0 559 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +brd-a59728941 BRD-A59728941 BRD-A59728941 12 3 HEPG2;HUH7;PHH 0.38419478795387674 0.34057486905819834 -0.057475851050445004 -0.7099447902292013 -0.7099447902292013 -1.1584016081418784 -1.5001986824005606 0.0 1 0.38419478795387674 0.38419478795387674 -0.7099447902292013 -0.7099447902292013 False False -1.9085009493421587 -2.6567216333243526 -4.03652705121502 3.860058144835679 568 342.0 553 1 0 True 23757080 False False False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pindolol pindolol BRD-A97701745 3 2 HEPG2;PHH 0.026605567170514 -0.11787777104311518 -0.4750071423394339 -0.1332937497645616 -0.4750071423394339 -1.2546441431456643 -1.3652155186458017 0.0 1 0.026605567170514 0.026605567170514 -0.4750071423394339 -0.4750071423394339 False False -1.937251902468565 -2.706386080013082 -2.9597256896836517 0.11180885810874411 569 543.0 557 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +pd-173074 PD-173074 BRD-K97764662 6 2 HEPG2;PHH -0.018950998731371405 -0.18207663031191462 -0.14439511299133295 -0.4916495964862406 -0.5807513096369803 -1.348074302269471 -1.4902482114229647 0.0 1 -0.018950998731371405 -0.018950998731371405 -0.5807513096369803 -0.5807513096369803 False False -2.093198407980953 -2.9757683462378584 -3.313221564944924 -0.38382866421305106 570 559.0 573 0 1 True 1401 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +colforsin colforsin BRD-A55416093 3 2 HEPG2;PHH 0.2332172017130586 -0.12068306882348323 -0.0509297054793153 -0.1191812455654144 -0.7537033520638943 -1.2996543551543875 -1.7131987578782535 0.0 1 0.2332172017130586 0.2332172017130586 -0.7537033520638943 -0.7537033520638943 False False -2.1562537340935144 -3.0846902267887164 -2.362803131593312 1.4403858357437485 571 175.0 300 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +disopyramide disopyramide BRD-A29734509 3 2 HEPG2;PHH 0.0511833396222856 0.0037559444705645498 -0.8197928475482124 0.1070787608623504 -0.8197928475482124 -1.3869197449114703 -1.607957920551093 0.0 1 0.0511833396222856 0.0511833396222856 -0.8197928475482124 -0.8197928475482124 False False -2.190898705187017 -3.1445360104168607 -4.154034036020053 0.6512636753156709 572 553.0 572 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +gw-5074 GW-5074 BRD-K07859598 3 2 HEPG2;PHH -0.2152752694156434 -0.27246402286820937 -0.3268965034346495 -0.0532312523573637 -0.5406569391489029 -1.460037399430774 -1.4817528801578437 0.0 1 -0.2152752694156434 -0.2152752694156434 -0.5406569391489029 -0.5406569391489029 False False -2.200913839509696 -3.1618361709528364 -2.4455620946115197 -1.9372467051348763 573 559.0 569 0 1 True True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +epirizole epirizole BRD-K39339537 3 2 HEPG2;PHH 0.1766340136528015 -0.11077386389176047 -0.1597142815589904 0.0842048525810241 -0.5903453174978495 -1.6136910001791658 -1.8091708709973664 0.0 1 0.1766340136528015 0.1766340136528015 -0.5903453174978495 -0.5903453174978495 False False -2.518276435677849 -3.71004887434018 -1.662023740847919 1.1051235764461487 574 183.0 279 0 1 True 3242 True True False manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized +tranilast tranilast BRD-K17849083;BRD-K19533706 3 2 HEPG2;PHH -0.0846625899689065 -0.1255979665244619 -0.7474523740155357 -0.0419770488515496 -0.7474523740155357 -1.5764443365975267 -2.0065005488383276 0.0 2 -0.1255979665244619 0.0586002945072121 -0.9291053265333177 -0.2931995924030031 True False -2.5796946110166905 -3.8161427377826898 -4.19828928303234 -0.632546654182975 575 573.0 574 0 1 True 5282230 True True True manual_review_required unresolved_or_not_curated False Tier_4_not_prioritized diff --git a/data/UQ_resolver_source_inputs/UQ_Visium_biopsy_module_means.tsv b/data/UQ_resolver_source_inputs/UQ_Visium_biopsy_module_means.tsv new file mode 100644 index 0000000..7771758 --- /dev/null +++ b/data/UQ_resolver_source_inputs/UQ_Visium_biopsy_module_means.tsv @@ -0,0 +1,34 @@ +biopsy_id patient_cluster array fibrosis_stage stage_numeric stage_group HSC_retention Endo_resolver LAM_resolver retention_dominance AP1_control TGFb_integrator ECM_scar +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 0.08762611383970355 0.08302477953021323 0.08516744293856852 0.003530002605312683 0.11820223131757189 0.13960063261029018 0.22100363082474905 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early -0.07394484265929133 -0.0487043875747739 -0.006577353692716711 -0.04630397202554602 -0.05447994815843177 -0.06138716731473978 -0.10893306356055187 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early -0.005788281369304318 -0.037453842758335895 -0.09795860665614133 0.061917943337934295 0.027564594266833362 0.006516095480950232 0.0969660069800327 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early -0.01920708719251315 -0.04558102113277704 -0.047187475473496714 0.027177161110623734 -0.04486131701363498 -0.030745362738424438 -0.07848208232658582 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 0.13445208833050493 0.09563775015447107 0.04872575960205436 0.062270333452242206 0.0832308476357503 0.13323886890201975 0.18037286572076294 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate -0.08667220559180104 -0.09849779524413681 0.031577558586254835 -0.053212087262860044 -0.057898464382291265 -0.06051893395470243 -0.11849299447628514 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 0.1136933701945909 0.03986957885165834 0.1309680222189944 0.028274569659264535 0.10720650933688945 0.08516119067557962 0.2368245289416857 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early -0.24903682404208036 -0.14416064630056782 -0.24042056288604144 -0.05674621944877572 -0.22995618379969635 -0.20982759815978122 -0.4338121189907829 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early -0.02342314415637877 -0.03142364332562741 -0.09597956597580663 0.04027846049433825 -0.017868164582279158 -0.08687005661167113 -0.32460741252468023 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 0.19295776962250716 0.0207035300677834 0.11228468461179415 0.12646366228271838 -0.012770500993287784 0.13696969986410798 0.3595816300625698 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate -0.006954021937807915 0.025035418842020308 -0.0017801888179373646 -0.01858163694984939 -0.10650732448076326 0.02623607904167544 0.04173354142875397 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early -0.1497206878990336 -0.06472291847436457 -0.06417920659331454 -0.08526962536519403 0.05858097555813652 -0.08369552276646272 -0.16575360012816 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 0.5731936224509785 0.2475456464017412 0.21590365254779795 0.341468972976209 0.04091543018167271 0.3589518772077147 0.9562616241318526 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early -0.1610077082050326 -0.06015142582325022 -0.21321526222785994 -0.024324364179477514 -0.030523755075308537 -0.09348300746998678 -0.32699957800050267 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early -0.20797068679001376 -0.07758973181018082 -0.09834138989139359 -0.12000512593922658 -0.15688866656162728 -0.09787622048914692 -0.4654459636638744 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early -0.03580415581871286 -0.04838783401375359 0.10059202372437569 -0.06190625067402391 0.036198969540048746 -0.035937427384042056 0.04124013090294489 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early -0.13530314450130182 -0.06270112863177466 -0.1317955960366531 -0.038054782167087936 -0.057543183733586925 -0.07451287204047956 -0.18896187370075188 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early -0.11438718484799411 -0.09544569819598059 0.031133857387328413 -0.08223126444366802 -0.1651466137514333 -0.09987266033868455 -0.17819001259207248 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate -0.045909402637107494 -0.06061921772239845 0.06813414848719955 -0.049666868019508044 0.08486100785068675 -0.05006435406689286 -0.033098358534137375 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 0.1770575185245888 0.12205691482475062 -0.040033963109164634 0.1360460426667958 0.03532957963320077 0.15775541864622936 0.2529014036462215 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late -0.0953156970176912 -0.10584792274877744 -0.057190445100739284 -0.013796513092932831 -0.00213727609734315 -0.2434757666456575 -0.25197024399191187 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 0.10549899616275087 -0.008747434791419312 0.00961624356559451 0.10506459177566327 -0.0033096807951507583 0.04286954154708875 0.11257107176498928 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 0.037496255942557476 0.04158982005941591 0.18563458518510711 -0.07611594667970403 0.049682053901486535 0.12733501014162218 0.1532570226149437 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early -0.11273064033879235 -0.06400339516049798 -0.20437793015547942 0.021460022319196352 -0.0762942819806521 -0.1275673079611599 -0.19337241397914906 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate -0.25894936883713615 -0.11531376009572165 -0.23089689165200214 -0.08584404296327429 -0.14849678039381378 -0.16270489863703305 -0.3884337749900063 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 0.136008761075034 0.04990471774423528 0.16583556959730542 0.028138617404263683 0.07433405070102525 0.11128920900050193 0.18199433001242707 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 0.01779009412164505 0.011634108477245995 -0.033653639409225194 0.028799859587634653 -0.007333941531825947 0.009835682382061306 0.0688759316280911 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 0.09116946031331388 -0.07407971996006635 0.07490667272197031 0.0907559839323619 0.04068961068258796 -0.03653821244914178 0.028937389921233306 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late -0.04807273432292679 0.008123113383222798 -0.005227746400025842 -0.04952041781452526 -0.09584434809733852 -0.039777981011259296 0.0695789539540202 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early -0.1578410581891883 -0.0765187187693421 -0.1564919313980337 -0.04133573310550044 -0.11502026396516962 -0.07519481596598801 -0.36584698146825156 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early -0.14432564427879246 0.0030020029606643577 -0.18737451562070942 -0.052139387948769926 -0.07972151001436119 -0.07757221649463886 -0.35750549125786835 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 0.1436065203472011 -0.005158015338717159 0.11884022514327912 0.08676541544492011 0.059996993244183214 0.06625526706230714 0.21210298218520632 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 0.13296888319717157 0.006679560965460714 0.1271151934803441 0.06607150597426915 0.14214219512453244 0.08772586182563796 0.2900733094610028 diff --git a/data/UQ_resolver_source_inputs/UQ_Visium_biopsy_spatial_coupling.tsv b/data/UQ_resolver_source_inputs/UQ_Visium_biopsy_spatial_coupling.tsv new file mode 100644 index 0000000..1f74c57 --- /dev/null +++ b/data/UQ_resolver_source_inputs/UQ_Visium_biopsy_spatial_coupling.tsv @@ -0,0 +1,199 @@ +biopsy_id patient_cluster array fibrosis_stage stage_numeric stage_group n_spots outcome covariates grid_long grid_cross beta beta_se beta_ci_low beta_ci_high spatial_field_p n_transforms n_blocks grid_occupancy residual_moran permuted_moran_min permuted_moran_max spatial_fdr_within_outcome +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 HSC_retention HSC_identity;log_library 8 4 0.045551593003391434 0.0349917361331341 -0.023032209817551406 0.11413539582433427 0.1484375 127 32 1.0 -0.05520143021418519 -0.055201430214185214 -0.05520143021418517 0.2578125 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.014614826069207033 0.04870092321367915 -0.0808389834296041 0.11006863556801816 0.703125 127 32 1.0 0.056112808031404414 0.05611280803140439 0.056112808031404435 0.9420072115384616 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.064557305940759 0.03607671851620713 -0.006153062351006988 0.13526767423252498 0.2109375 127 32 1.0 -0.04653963502181695 -0.04653963502181696 -0.04653963502181693 0.48125 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.002676765353541949 0.04142551196163284 -0.07851723809125842 0.08387076879834231 0.953125 127 32 1.0 -0.2241192336107432 -0.22411923361074326 -0.22411923361074318 0.96875 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 AP1_control HSC_identity;log_library 8 4 0.014434638476568673 0.03535031744471849 -0.05485198371507957 0.08372126066821692 0.734375 127 32 1.0 0.1331705442486905 0.1331705442486905 0.13317054424869054 0.8067036290322581 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.030429184212686707 0.03888828868744562 -0.04579186161470671 0.10665023004008012 0.3125 127 32 1.0 -0.09382264616736254 -0.09382264616736256 -0.09382264616736254 0.5859375 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 HSC_retention HSC_identity;log_library 8 4 0.042723623808867045 0.01940894974826254 0.004682082302272468 0.08076516531546163 0.1328125 127 32 1.0 0.24327488543953749 0.24327488543953743 0.24327488543953757 0.24348958333333334 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.012197731519341169 0.016066977185440687 -0.019293543764122574 0.043689006802804915 0.515625 127 32 1.0 -0.08040604317151455 -0.08040604317151456 -0.08040604317151452 0.8348214285714286 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.0077506859367681615 0.036611789679989896 -0.07950979370954835 0.06400842183601203 0.8515625 127 32 1.0 -0.1402082121460079 -0.14020821214600793 -0.1402082121460079 0.878173828125 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.0018581945428374055 0.01930583044876689 -0.039697622222420514 0.0359812331367457 0.8828125 127 32 1.0 -0.09936647896327314 -0.09936647896327315 -0.09936647896327311 0.96875 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 AP1_control HSC_identity;log_library 8 4 0.00781300179265517 0.020126107588030046 -0.031634169079883714 0.047260172665194056 0.7109375 127 32 1.0 -0.07783917775840343 -0.07783917775840343 -0.07783917775840342 0.8067036290322581 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.035090495743759574 0.02504706793304103 -0.014001757405000842 0.08418274889251999 0.1171875 127 32 1.0 -0.20245197213629101 -0.20245197213629107 -0.20245197213629101 0.322265625 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 HSC_retention HSC_identity;log_library 8 4 0.04539840145679032 0.03274517086740676 -0.018782133443326937 0.10957893635690757 0.109375 127 32 1.0 0.029774533871309673 0.029774533871309666 0.029774533871309683 0.24169921875 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.019166049936537196 0.025241823095824907 -0.03030792333127962 0.06864002320435401 0.3984375 127 32 1.0 -0.20614846518837726 -0.20614846518837732 -0.20614846518837723 0.8348214285714286 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.005582615944080646 0.026549976977920463 -0.05762057082080475 0.04645533893264346 0.8203125 127 32 1.0 -0.29429692360148046 -0.2942969236014805 -0.29429692360148035 0.878173828125 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0410135833464663 0.02955154948485106 -0.016907453643841774 0.09893462033677437 0.078125 127 32 1.0 0.035733562511976465 0.03573356251197645 0.03573356251197648 0.3046875 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 AP1_control HSC_identity;log_library 8 4 -0.022129810238871218 0.04780640517238363 -0.11583036437674313 0.0715707438990007 0.5390625 127 32 1.0 -0.28159213437006203 -0.28159213437006203 -0.281592134370062 0.6841947115384616 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.035234655936845445 0.03275326794356736 -0.02896174923254658 0.09943106110623748 0.4296875 127 32 1.0 0.2044461144124028 0.2044461144124028 0.20444611441240285 0.6165081521739131 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 HSC_retention HSC_identity;log_library 8 4 0.0020825576090289706 0.03158413233503148 -0.059822341767632736 0.06398745698569068 0.9296875 127 32 1.0 0.0885097286007272 0.08850972860072719 0.08850972860072721 0.9296875 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.0006858008933042782 0.02716667656777449 -0.05256088517953372 0.05393248696614228 0.96875 127 32 1.0 0.014539082874352564 0.014539082874352564 0.014539082874352594 0.96875 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.06595452622073765 0.032931146205751494 0.0014094796574647267 0.1304995727840106 0.0546875 127 32 1.0 -0.06950541049717364 -0.06950541049717364 -0.06950541049717361 0.2578125 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.0401989273415837 0.024780625125021962 -0.08876895258662675 0.008371097903459343 0.125 127 32 1.0 0.20244849516750002 0.20244849516749996 0.20244849516750005 0.3265625 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 AP1_control HSC_identity;log_library 8 4 0.07537944137270418 0.04178691886166098 -0.006522919596151339 0.1572818023415597 0.03125 127 32 1.0 -0.20762487114368758 -0.2076248711436876 -0.20762487114368758 0.171875 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.05609359235304392 0.026212906465421536 0.00471629568081771 0.10747088902527013 0.03125 127 32 1.0 0.0247631098077852 0.02476310980778518 0.0247631098077852 0.1611328125 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 HSC_retention HSC_identity;log_library 8 4 0.25394422856573934 0.052293648937591954 0.1514486766480591 0.35643978048341957 0.0078125 127 27 0.84375 0.09684279808868701 0.09684279808868691 0.09684279808868702 0.04296875 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.056373441522112794 0.03362308206277427 -0.009527799320924776 0.12227468236515036 0.1015625 127 27 0.84375 0.12199242153453166 0.12199242153453164 0.12199242153453169 0.4583333333333333 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.1441901292556238 0.07712636757386193 -0.006977551189145587 0.29535780970039316 0.1015625 127 27 0.84375 0.06502994713538543 0.06502994713538542 0.06502994713538546 0.4125 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.12166590940838191 0.08638491017580348 -0.04764851453619291 0.29098033335295675 0.1015625 127 27 0.84375 -0.20477854499169468 -0.20477854499169468 -0.20477854499169462 0.3046875 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 AP1_control HSC_identity;log_library 8 4 0.14073095756510356 0.051393968548852406 0.03999877920935285 0.24146313592085428 0.0390625 127 27 0.84375 0.025702417059866665 0.025702417059866655 0.025702417059866683 0.18415178571428573 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.19506530316725967 0.06696130498031351 0.06382114540584519 0.3263094609286742 0.0078125 127 27 0.84375 0.0009116447341151603 0.0009116447341151394 0.0009116447341151859 0.0859375 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 HSC_retention HSC_identity;log_library 8 4 0.040135947946452304 0.03506221908545866 -0.028586001461046666 0.10885789735395127 0.4375 127 32 1.0 0.19761815056289525 0.1976181505628952 0.19761815056289525 0.5552884615384616 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.008124296991316572 0.018119364946621534 -0.027389658304061634 0.04363825228669478 0.53125 127 32 1.0 -0.3072255726093859 -0.3072255726093859 -0.30722557260938577 0.8348214285714286 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.041137016439404005 0.03268971197547946 -0.022934819032535726 0.10520885191134374 0.296875 127 32 1.0 0.09470832326815946 0.09470832326815944 0.09470832326815948 0.55859375 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.009693151691134294 0.02639277848009138 -0.04203669412984481 0.06142299751211339 0.703125 127 32 1.0 -0.061026644046925003 -0.06102664404692501 -0.06102664404692498 0.8924278846153846 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 AP1_control HSC_identity;log_library 8 4 0.03319349239126153 0.03613426916606919 -0.03762967517423409 0.10401665995675714 0.4140625 127 32 1.0 0.09658133844219285 0.09658133844219285 0.09658133844219287 0.5693359375 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.006260665269631513 0.02585543398638962 -0.04441598534369214 0.05693731588295516 0.7734375 127 32 1.0 -0.16944845391110355 -0.16944845391110355 -0.16944845391110352 0.8801185344827587 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 HSC_retention HSC_identity;log_library 8 4 0.11552777974307435 0.025276110035549075 0.06598660407339815 0.16506895541275055 0.0078125 127 32 1.0 -0.03228242365831791 -0.032282423658317926 -0.032282423658317905 0.04296875 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.002850547776737138 0.026547950348390338 -0.04918343490610793 0.0548845304595822 0.9453125 127 32 1.0 -0.1125379905864636 -0.11253799058646363 -0.11253799058646356 0.96875 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03949582673440876 0.0314766838160216 -0.02219847354499358 0.10119012701381111 0.1953125 127 32 1.0 0.059649141480478333 0.059649141480478306 0.05964914148047835 0.48125 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.06573321969284993 0.031157003399306923 0.004665493030208356 0.1268009463554915 0.0546875 127 32 1.0 -0.015357487040276238 -0.015357487040276284 -0.015357487040276226 0.30078125 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 AP1_control HSC_identity;log_library 8 4 0.08085414543948549 0.04694233079178748 -0.011152822912417967 0.17286111379138897 0.1015625 127 32 1.0 0.029145934916252524 0.029145934916252506 0.029145934916252555 0.2578125 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.018236989663940828 0.0295790300265709 -0.03973790918813814 0.07621188851601979 0.53125 127 32 1.0 -0.15296675771235815 -0.15296675771235815 -0.15296675771235813 0.73046875 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 HSC_retention HSC_identity;log_library 8 4 0.025430129196932688 0.025252425155407272 -0.024064624107665564 0.07492488250153094 0.34375 127 32 1.0 0.17446442613930607 0.17446442613930607 0.17446442613930607 0.47265625 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.022121837804279804 0.018701685625862004 -0.014533466022409725 0.05877714163096934 0.1953125 127 32 1.0 0.15124155623388846 0.15124155623388844 0.1512415562338885 0.5859375 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.031220848978912207 0.027043328093083595 -0.021784074083531637 0.08422577204135605 0.203125 127 32 1.0 -0.22450161102120877 -0.22450161102120883 -0.22450161102120872 0.48125 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.014930867232385804 0.030466747012275683 -0.044783956911674534 0.07464569137644614 0.640625 127 32 1.0 0.12443521816824854 0.12443521816824851 0.12443521816824854 0.845625 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 AP1_control HSC_identity;log_library 8 4 0.029930576120712354 0.02643877394226618 -0.02188942080612936 0.08175057304755406 0.3046875 127 32 1.0 -0.24688108635507078 -0.2468810863550708 -0.24688108635507075 0.502734375 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.01320465040691624 0.0280930276905937 -0.041857683866647406 0.06826698468047988 0.5859375 127 32 1.0 -0.29403843405663815 -0.29403843405663815 -0.29403843405663804 0.7734375 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 HSC_retention HSC_identity;log_library 8 4 -0.02393612068259545 0.03168839997889434 -0.08604538464122835 0.038173143276037456 0.5078125 127 31 0.96875 0.08989785927268847 0.08989785927268844 0.08989785927268848 0.6206597222222222 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.0069495666038062644 0.03243343053711131 -0.07051909045654443 0.05661995724893191 0.828125 127 31 0.96875 -0.11566632668776308 -0.1156663266877631 -0.11566632668776303 0.9564012096774194 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.017677855384916497 0.025435682499349816 -0.03217608231380914 0.06753179308364214 0.609375 127 31 0.96875 -0.0454420554159561 -0.045442055415956126 -0.04544205541595608 0.804375 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.028623453214789523 0.036175918515616655 -0.09952825350539816 0.04228134707581911 0.4453125 127 31 0.96875 -0.10272728081020309 -0.10272728081020309 -0.10272728081020302 0.6997767857142857 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 AP1_control HSC_identity;log_library 8 4 -0.03807345596711975 0.04064438959263335 -0.11773645956868112 0.041589547634441615 0.5 127 31 0.96875 0.12116074647509928 0.12116074647509928 0.12116074647509933 0.66 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.0004162616470475496 0.03823592175591369 -0.0753586682886384 0.07452614499454328 0.9921875 127 31 0.96875 0.14236080083357391 0.14236080083357386 0.14236080083357394 0.9921875 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 HSC_retention HSC_identity;log_library 8 4 0.07036436058598704 0.07233029491032951 -0.07140301743825879 0.21213173861023288 0.2265625 127 32 1.0 0.057045136261572496 0.057045136261572454 0.05704513626157251 0.33984375 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.01977219439962935 0.03311445870808572 -0.08467653346747736 0.04513214466821866 0.6171875 127 32 1.0 0.01903080076015159 0.01903080076015157 0.01903080076015159 0.92578125 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.020237747532291437 0.05014672030939066 -0.11852531933869712 0.07804982427411425 0.734375 127 32 1.0 0.14347379862872486 0.14347379862872484 0.14347379862872486 0.878173828125 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.05279620484018888 0.047308836207315186 -0.03992911412614888 0.14552152380652664 0.1484375 127 32 1.0 -0.13771355158225954 -0.13771355158225956 -0.13771355158225948 0.3265625 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 AP1_control HSC_identity;log_library 8 4 0.09464316392341063 0.052341137382219106 -0.007945465345738825 0.19723179319256007 0.0546875 127 32 1.0 0.2814646879200188 0.28146468792001866 0.2814646879200188 0.20052083333333334 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.017134415698623687 0.046488625199835494 -0.07398328969305389 0.10825212109030126 0.7109375 127 32 1.0 -0.024171391355007826 -0.02417139135500784 -0.024171391355007812 0.8689236111111112 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 HSC_retention HSC_identity;log_library 8 4 0.05233191905451619 0.02675585608956458 -0.00010955888103039019 0.10477339699006277 0.1171875 127 32 1.0 0.018284740233293177 0.01828474023329315 0.018284740233293205 0.24169921875 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.017587920520838858 0.016443871816434426 -0.04981790928105033 0.014642068239372613 0.2421875 127 32 1.0 -0.0453280391465105 -0.04532803914651051 -0.0453280391465105 0.6077008928571429 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.011869024031637613 0.024737654664437152 -0.036616779110659206 0.060354827173934436 0.671875 127 32 1.0 -0.07620753611007038 -0.0762075361100704 -0.07620753611007036 0.8527644230769231 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.04463049565230387 0.02043072649174972 0.004586271728474416 0.08467471957613332 0.09375 127 32 1.0 0.16873026262965543 0.16873026262965538 0.16873026262965546 0.3046875 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 AP1_control HSC_identity;log_library 8 4 -0.02273248067139559 0.02237234259351012 -0.06658227215467542 0.02111731081188424 0.3828125 127 32 1.0 0.1297420591397895 0.12974205913978948 0.12974205913978953 0.5604619565217391 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.017087875794343833 0.023667354170604626 -0.029300138380041234 0.0634758899687289 0.328125 127 32 1.0 -0.14554271893543605 -0.1455427189354361 -0.14554271893543605 0.5859375 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 HSC_retention HSC_identity;log_library 8 4 0.003576069181105665 0.020255325864692628 -0.036124369513691884 0.04327650787590322 0.859375 127 32 1.0 0.011176941491978903 0.011176941491978891 0.01117694149197892 0.90234375 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.031858297968872844 0.026841075509505333 -0.08446680596750329 0.020750210029757604 0.125 127 32 1.0 -0.30411849318042145 -0.30411849318042145 -0.3041184931804213 0.4583333333333333 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.034035355333707044 0.04990807046464832 -0.06378446277700367 0.13185517344441774 0.46875 127 32 1.0 -0.11351560899839727 -0.11351560899839731 -0.11351560899839727 0.73046875 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0018870291568179852 0.04065362365999825 -0.07779407321677859 0.08156813153041456 0.9609375 127 32 1.0 -0.10748946689971431 -0.10748946689971434 -0.10748946689971427 0.96875 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 AP1_control HSC_identity;log_library 8 4 -0.04224144883478804 0.049307007338346066 -0.13888318321794632 0.05440028554837025 0.3828125 127 32 1.0 0.031756965791358 0.03175696579135799 0.03175696579135802 0.5604619565217391 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.00814068510770496 0.04539025654888984 -0.09710558794352905 0.08082421772811912 0.921875 127 32 1.0 -0.06501547336761469 -0.06501547336761469 -0.06501547336761468 0.95068359375 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 HSC_retention HSC_identity;log_library 8 4 0.15119910860666586 0.08490118383886935 -0.015207211717518071 0.31760542893084975 0.1328125 127 32 1.0 0.018170268351886894 0.018170268351886877 0.0181702683518869 0.24348958333333334 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.08515768127019027 0.04815975759547705 -0.009235443616944741 0.17955080615732527 0.0703125 127 32 1.0 -0.05035803088916444 -0.05035803088916446 -0.05035803088916443 0.38671875 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.10602732899725505 0.054138226746994256 -0.21213825342136378 8.359542685369703e-05 0.125 127 32 1.0 0.08340887487013489 0.08340887487013487 0.0834088748701349 0.4125 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.11180463475144307 0.08164560158165611 -0.04822074434860289 0.271830013851489 0.1484375 127 32 1.0 -0.08829996692536138 -0.08829996692536142 -0.08829996692536138 0.3265625 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 AP1_control HSC_identity;log_library 8 4 0.11743801729738362 0.05773657672470698 0.004274326916957949 0.2306017076778093 0.078125 127 32 1.0 -0.027856140626926307 -0.02785614062692633 -0.027856140626926294 0.234375 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.11549624480001601 0.0846862579757132 -0.05048882083238186 0.28148131043241387 0.296875 127 32 1.0 -0.04670274602541425 -0.04670274602541431 -0.04670274602541425 0.5859375 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 HSC_retention HSC_identity;log_library 8 4 -0.009518008485339515 0.01948045789843221 -0.047699705966266645 0.02866368899558762 0.625 127 32 1.0 -0.205191464306162 -0.20519146430616206 -0.20519146430616197 0.7112068965517241 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.0220036775061633 0.028670975910274052 -0.034191435277973845 0.07819879029030044 0.421875 127 32 1.0 -0.14144196531882616 -0.14144196531882622 -0.14144196531882616 0.8348214285714286 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07397207612606556 0.028131808121931175 0.018833732207080456 0.12911042004505066 0.0078125 127 32 1.0 -0.02198625332530103 -0.021986253325301058 -0.02198625332530102 0.21484375 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.06177091776381282 0.028200715201918327 -0.11704431955957274 -0.006497515968052897 0.0390625 127 32 1.0 -0.1862114236030661 -0.18621142360306614 -0.18621142360306606 0.30078125 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 AP1_control HSC_identity;log_library 8 4 -0.0222644813485011 0.054875894327316245 -0.12982123423004094 0.08529227153303873 0.6875 127 32 1.0 0.22753564090958336 0.2275356409095833 0.22753564090958342 0.8067036290322581 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08926447725701454 0.04188510703920754 0.00716966746016777 0.17135928705386133 0.03125 127 32 1.0 -0.13896161994541392 -0.13896161994541392 -0.13896161994541387 0.1611328125 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 HSC_retention HSC_identity;log_library 8 4 -0.013094626632936675 0.02334011174136567 -0.05884124564601339 0.03265199238014004 0.578125 127 28 0.875 0.029757503750501256 0.029757503750501242 0.029757503750501266 0.6813616071428571 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.022437833278889364 0.038648106052301415 -0.09818812114140013 0.05331245458362141 0.5078125 127 28 0.875 -0.08119721502105348 -0.08119721502105348 -0.08119721502105344 0.8348214285714286 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.06679662955195548 0.04907954992377132 -0.02939928829863632 0.16299254740254726 0.21875 127 28 0.875 -0.04252754878726589 -0.04252754878726591 -0.042527548787265876 0.48125 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.03759167577936354 0.02889005456536994 -0.09421618272748862 0.019032831168761546 0.1484375 127 28 0.875 -0.06730378583106188 -0.06730378583106193 -0.06730378583106188 0.3265625 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 AP1_control HSC_identity;log_library 8 4 0.020539828914729552 0.06514945218982134 -0.10715309737732026 0.14823275520677937 0.7578125 127 28 0.875 0.23441517759487274 0.23441517759487263 0.23441517759487274 0.8067036290322581 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.19166111781122155 0.06364760837167194 0.06691180540274456 0.31641043021969856 0.0078125 127 28 0.875 0.04684001436071985 0.046840014360719835 0.04684001436071986 0.0859375 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 HSC_retention HSC_identity;log_library 8 4 0.0310434256921454 0.020374222383505388 -0.008890050179525159 0.07097690156381596 0.09375 127 30 0.9375 -0.17034092781296278 -0.1703409278129628 -0.17034092781296276 0.23798076923076922 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.02698594093499492 0.02610150867873847 -0.07814489794532233 0.024173016075332482 0.2578125 127 30 0.9375 0.2554494191625443 0.25544941916254427 0.2554494191625443 0.6077008928571429 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.10349001750664481 0.042324341061556074 0.020534309025994915 0.1864457259872947 0.03125 127 30 0.9375 -0.07967218492797938 -0.07967218492797938 -0.07967218492797937 0.21484375 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.02015250479113733 0.027728802505581553 -0.07450095770207718 0.03419594811980251 0.2890625 127 30 0.9375 -0.13387954274375044 -0.13387954274375044 -0.13387954274375038 0.476953125 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 AP1_control HSC_identity;log_library 8 4 0.05487739408726364 0.0426233084094133 -0.028664290395186434 0.1384190785697137 0.2265625 127 30 0.9375 0.08030147313970132 0.0803014731397013 0.08030147313970132 0.4296875 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.0742085222440832 0.03581881765739005 0.004003639635598702 0.1444134048525677 0.0390625 127 30 0.9375 0.017703393777492204 0.017703393777492187 0.017703393777492204 0.1611328125 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 HSC_retention HSC_identity;log_library 8 4 0.09749356678754201 0.026147015998001486 0.046245415431459096 0.1487417181436249 0.03125 127 28 0.875 0.15095741299401755 0.15095741299401752 0.15095741299401758 0.103125 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.020478152918664592 0.03930314731072857 -0.09751232164769259 0.056556015810363416 0.53125 127 28 0.875 0.11421252057005657 0.11421252057005656 0.11421252057005657 0.8348214285714286 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.1374384300183248 0.044199093740583104 0.0508082062867819 0.22406865374986767 0.0390625 127 28 0.875 0.06698621069177772 0.0669862106917777 0.06698621069177774 0.21484375 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.00983681337506254 0.035958633012103884 -0.06064210732866107 0.08031573407878614 0.828125 127 28 0.875 0.18114360519248868 0.18114360519248865 0.1811436051924887 0.9423491379310345 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 AP1_control HSC_identity;log_library 8 4 -0.010811334789618857 0.05756667035105355 -0.12364200867768381 0.10201933909844609 0.84375 127 28 0.875 0.18390869627611078 0.18390869627611073 0.1839086962761108 0.84375 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.035108005302720575 0.049889245998157396 -0.06267491685366791 0.13289092745910908 0.3359375 127 28 0.875 -0.06685837558332568 -0.0668583755833257 -0.06685837558332566 0.5859375 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 HSC_retention HSC_identity;log_library 8 4 -0.015676401767745072 0.01799856760275582 -0.050953594269146474 0.019600790733656333 0.2109375 127 32 1.0 0.01570788942384098 0.015707889423840958 0.015707889423840982 0.3314732142857143 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.011824158294976787 0.023795833632044343 -0.034815675623830124 0.0584639922137837 0.7265625 127 32 1.0 -0.05582858408753578 -0.05582858408753579 -0.05582858408753576 0.9420072115384616 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.025567442323167117 0.029834728175158646 -0.03290862490014383 0.08404350954647806 0.25 127 32 1.0 -0.0995891780149854 -0.09958917801498543 -0.09958917801498539 0.515625 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.03487596419904598 0.02327843909487418 -0.08050170482499938 0.010749776426907408 0.09375 127 32 1.0 0.07081131105129998 0.07081131105129997 0.07081131105130001 0.3046875 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 AP1_control HSC_identity;log_library 8 4 0.05930471552139824 0.02677620268237873 0.00682335826393593 0.11178607277886055 0.046875 127 32 1.0 0.04988246134583721 0.049882461345837195 0.04988246134583722 0.193359375 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.009612247103119713 0.022801859991805142 -0.03507939848081837 0.05430389268705779 0.7421875 127 32 1.0 0.1030838313437641 0.10308383134376407 0.1030838313437641 0.8747209821428571 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 HSC_retention HSC_identity;log_library 8 4 0.04642028203870064 0.032375458963464124 -0.01703561752968904 0.10987618160709031 0.1171875 127 32 1.0 0.13839135290998805 0.13839135290998805 0.1383913529099881 0.24169921875 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.004528574265365727 0.018341761826838027 -0.0314212789152368 0.04047842744596826 0.8671875 127 32 1.0 0.03668778517589933 0.03668778517589932 0.03668778517589937 0.9564012096774194 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04009998662224662 0.030322989664053612 -0.01933307311929846 0.0995330463637917 0.3046875 127 32 1.0 -0.032303166516465864 -0.03230316651646587 -0.03230316651646585 0.55859375 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.01636540659192577 0.027067386997794686 -0.036686671923751815 0.06941748510760336 0.546875 127 32 1.0 -0.12812198700309074 -0.1281219870030908 -0.12812198700309074 0.8203125 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 AP1_control HSC_identity;log_library 8 4 0.051549829159739484 0.032943692799889665 -0.013019808728044265 0.11611946704752324 0.2890625 127 32 1.0 0.017736406973762303 0.017736406973762286 0.01773640697376233 0.5020559210526315 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.01942980696023377 0.024975603345183964 -0.029522375596326797 0.06838198951679433 0.390625 127 32 1.0 -0.024199711431415638 -0.024199711431415687 -0.02419971143141563 0.5859375 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 HSC_retention HSC_identity;log_library 8 4 0.2706307667520711 0.06434877773154207 0.14450716239824862 0.39675437110589357 0.0078125 127 32 1.0 0.08585848413681957 0.08585848413681955 0.0858584841368196 0.04296875 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.020909647055406298 0.05502282327378512 -0.08693508656121253 0.12875438067202513 0.7421875 127 32 1.0 0.058716715993704066 0.05871671599370405 0.05871671599370408 0.9420072115384616 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03519533920942061 0.06451532170941174 -0.0912546913410264 0.16164536975986762 0.53125 127 32 1.0 -0.011807624449517586 -0.011807624449517592 -0.01180762444951757 0.73046875 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.08505413847325326 0.06077271422786831 -0.03406038141336863 0.20416865835987513 0.171875 127 32 1.0 0.10102763071359354 0.10102763071359351 0.10102763071359354 0.3544921875 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 AP1_control HSC_identity;log_library 8 4 0.17155389669237944 0.054128318500327295 0.06546239243173795 0.2776454009530209 0.0234375 127 32 1.0 0.09279974948781122 0.09279974948781118 0.09279974948781124 0.1546875 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.06362858808315669 0.08464359428684347 -0.1022728567190565 0.22953003288536988 0.3828125 127 32 1.0 -0.25033680371837386 -0.2503368037183739 -0.2503368037183738 0.5859375 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 HSC_retention HSC_identity;log_library 8 4 0.06634224139816879 0.04768987394715995 -0.027129911538264717 0.1598143943346023 0.296875 127 31 0.96875 0.13509986131016913 0.13509986131016913 0.13509986131016913 0.42595108695652173 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.06830994378012964 0.03671853782949648 -0.003658390365683467 0.14027827792594275 0.1171875 127 31 0.96875 -0.0721925292420094 -0.0721925292420094 -0.07219252924200938 0.4583333333333333 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.028892109472407702 0.055743595103364935 -0.08036533693018758 0.13814955587500297 0.515625 127 31 0.96875 -0.04593654478014189 -0.04593654478014191 -0.04593654478014187 0.73046875 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.032755478377958246 0.06768642295680397 -0.09990991061737753 0.16542086737329403 0.734375 127 31 0.96875 0.08115780642763798 0.08115780642763797 0.08115780642763801 0.8975694444444444 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 AP1_control HSC_identity;log_library 8 4 0.07155664212074696 0.06860713857574167 -0.06291334948770673 0.20602663372920066 0.234375 127 31 0.96875 -0.10664519443268608 -0.1066451944326861 -0.10664519443268602 0.4296875 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.044586121340701494 0.04833396532317697 -0.05014845069272537 0.13932069337412836 0.328125 127 31 0.96875 -0.002458467634290003 -0.002458467634290003 -0.0024584676342899884 0.5859375 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 HSC_retention HSC_identity;log_library 8 4 0.19835606200459355 0.04277185437723463 0.11452322742521368 0.2821888965839734 0.0078125 127 32 1.0 0.12306534885901009 0.12306534885901005 0.12306534885901015 0.04296875 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.003409985491638526 0.028415971309893085 -0.05228531827575192 0.05910528925902897 0.890625 127 32 1.0 -0.13866590233553752 -0.13866590233553755 -0.1386659023355375 0.9564012096774194 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.08919783084304961 0.043678982243214884 0.0035870256463484407 0.17480863603975078 0.0390625 127 32 1.0 0.05612353997967021 0.056123539979670206 0.05612353997967027 0.21484375 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.11410739046309945 0.03836186815044101 0.03891812888823508 0.1892966520379638 0.046875 127 32 1.0 -0.008373890254363045 -0.008373890254363057 -0.008373890254363036 0.30078125 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 AP1_control HSC_identity;log_library 8 4 0.0038314857818226144 0.02475264499891815 -0.04468369841605696 0.05234666997970219 0.828125 127 32 1.0 0.20206895441235587 0.20206895441235587 0.20206895441235587 0.84375 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.03001268745523916 0.03492981517772109 -0.03844975029309418 0.0984751252035725 0.359375 127 32 1.0 0.048428768522343305 0.0484287685223433 0.04842876852234332 0.5859375 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 HSC_retention HSC_identity;log_library 8 4 0.11423915984508663 0.04316438543492844 0.02963696439262689 0.19884135529754637 0.0390625 127 32 1.0 0.15905591844550115 0.15905591844550115 0.15905591844550118 0.1171875 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.030450254932993703 0.02703432064404871 -0.02253701352934177 0.08343752339532917 0.25 127 32 1.0 0.1015073383288384 0.10150733832883839 0.10150733832883843 0.6077008928571429 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.01606115897372698 0.047165435436090794 -0.10850541242846494 0.07638309448101098 0.828125 127 32 1.0 0.04357768231708645 0.043577682317086426 0.04357768231708649 0.878173828125 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0502416065616474 0.036810283280952594 -0.021906548669019685 0.12238976179231449 0.1953125 127 32 1.0 -0.03185353835691802 -0.03185353835691804 -0.031853538356918 0.3723958333333333 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 AP1_control HSC_identity;log_library 8 4 0.04353185603076303 0.04577975304473147 -0.04619645993691065 0.1332601719984367 0.390625 127 32 1.0 0.09862138205823726 0.09862138205823724 0.09862138205823727 0.5604619565217391 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08961958057812612 0.02785323066703682 0.03502724847073395 0.1442119126855183 0.0078125 127 32 1.0 -0.028402602144766084 -0.028402602144766104 -0.028402602144766084 0.0859375 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 HSC_retention HSC_identity;log_library 8 4 -0.01223661117018496 0.03551881399527296 -0.08185348660091996 0.05738026426055004 0.671875 127 32 1.0 -0.010813071116433277 -0.010813071116433315 -0.010813071116433277 0.7390625 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.05017424027929221 0.02521893474062343 0.0007451281876702867 0.09960335237091414 0.0625 127 32 1.0 0.06410818414671017 0.06410818414671014 0.06410818414671018 0.38671875 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.10316936543283771 0.03975346585077587 0.025252572365317014 0.18108615850035842 0.03125 127 32 1.0 -0.042385522751944106 -0.04238552275194415 -0.042385522751944106 0.21484375 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.11578534269638031 0.0464027505414765 -0.20673473375767426 -0.024835951635086367 0.03125 127 32 1.0 -0.0014100615616928565 -0.0014100615616928728 -0.0014100615616928398 0.30078125 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 AP1_control HSC_identity;log_library 8 4 0.1418267229319079 0.04883407248246946 0.046111940866267756 0.23754150499754806 0.0234375 127 32 1.0 0.2670361943061338 0.2670361943061338 0.2670361943061338 0.1546875 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.007681729670227766 0.04615089878387437 -0.082774031946166 0.09813749128662153 0.828125 127 32 1.0 0.026955897551989908 0.026955897551989894 0.02695589755198994 0.9109375 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 HSC_retention HSC_identity;log_library 8 4 0.03736570982885237 0.02263458626015497 -0.006998079241051364 0.08172949889875611 0.0625 127 32 1.0 -0.08702342782848987 -0.08702342782848989 -0.08702342782848985 0.171875 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.03305616922981936 0.016535266026107234 0.000647047818649181 0.06546529064098955 0.015625 127 32 1.0 -0.04961124989517849 -0.04961124989517852 -0.04961124989517847 0.171875 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.012522864302471832 0.024207725477208574 -0.03492427763285697 0.05997000623780064 0.53125 127 32 1.0 0.222842622712775 0.22284262271277494 0.222842622712775 0.73046875 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.007859652388093784 0.027428649066043902 -0.04590049978135226 0.061619804557539834 0.796875 127 32 1.0 -0.008618912272155128 -0.008618912272155149 -0.008618912272155107 0.9391741071428571 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 AP1_control HSC_identity;log_library 8 4 0.033260169976854256 0.02164112022329973 -0.009156425660813212 0.07567676561452172 0.0859375 127 32 1.0 -0.24138999504935577 -0.24138999504935582 -0.2413899950493557 0.236328125 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.006041574175582712 0.021553479301400405 -0.03620324525516208 0.0482863936063275 0.6328125 127 32 1.0 0.004832249745234888 0.004832249745234883 0.004832249745234909 0.8031850961538461 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 HSC_retention HSC_identity;log_library 8 4 0.19215060918230165 0.042872104618239974 0.1081212841305513 0.27617993423405196 0.015625 127 32 1.0 0.12391633997598447 0.12391633997598447 0.12391633997598452 0.064453125 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.013366953977135724 0.026136517792175566 -0.037860620895528385 0.06459452884979983 0.6484375 127 32 1.0 0.01950872495383079 0.01950872495383079 0.0195087249538308 0.9303668478260869 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.08771229522410545 0.030751065447681858 0.02744020694664901 0.1479843835015619 0.0234375 127 32 1.0 0.03641023914486489 0.036410239144864874 0.03641023914486491 0.21484375 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.09008691539227204 0.032165117110249504 0.027043285856183014 0.15313054492836106 0.0234375 127 32 1.0 0.0777491809710572 0.07774918097105715 0.07774918097105724 0.30078125 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 AP1_control HSC_identity;log_library 8 4 0.12532855165536191 0.04277779373455758 0.041484075935629056 0.20917302737509477 0.0078125 127 32 1.0 0.03550518222142226 0.03550518222142224 0.03550518222142226 0.1546875 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.06750126224877907 0.027087618474366783 0.01440953003902018 0.12059299445853797 0.078125 127 32 1.0 0.22733000976866444 0.2273300097686644 0.2273300097686645 0.2578125 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 HSC_retention HSC_identity;log_library 8 4 0.15131950194088467 0.061234508152305495 0.031299865962365905 0.27133913791940345 0.03125 127 32 1.0 0.25502862202070825 0.25502862202070814 0.2550286220207083 0.103125 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.06983762096789999 0.0339287507906103 0.003337269418303798 0.1363379725174962 0.0703125 127 32 1.0 0.08855276980698538 0.08855276980698537 0.08855276980698541 0.38671875 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.010046133472308656 0.03838721484728826 -0.08528507457299364 0.06519280762837634 0.7890625 127 32 1.0 0.19291234154817988 0.19291234154817985 0.19291234154817996 0.878173828125 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.02904388811735228 0.05734164263771301 -0.08334573145256521 0.14143350768726978 0.5859375 127 32 1.0 0.12310193438767511 0.1231019343876751 0.12310193438767514 0.837890625 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 AP1_control HSC_identity;log_library 8 4 0.016739774733709713 0.0456183891799146 -0.07267226805892289 0.10615181752634233 0.75 127 32 1.0 -0.017898282644803035 -0.017898282644803063 -0.01789828264480303 0.8067036290322581 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.047998254289625585 0.03308930521104478 -0.016856783924022185 0.11285329250327336 0.0625 127 32 1.0 -0.13543470281436593 -0.13543470281436598 -0.1354347028143659 0.22916666666666666 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 HSC_retention HSC_identity;log_library 8 4 0.26237283877742207 0.04776079208340943 0.1687616862939396 0.3559839912609045 0.0078125 127 23 0.71875 -0.017525861600573983 -0.017525861600573997 -0.01752586160057397 0.04296875 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.033077420606072785 0.026852210316235373 -0.08570775282589412 0.019552911613748544 0.1953125 127 23 0.71875 0.10832503669450172 0.1083250366945017 0.10832503669450173 0.5859375 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.08334030450785536 0.07721749967170484 -0.06800599484868612 0.23468660386439683 0.328125 127 23 0.71875 0.267762377664109 0.26776237766410893 0.267762377664109 0.5699013157894737 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.1859850139885526 0.05961696537448615 0.06913576185455975 0.3028342661225455 0.015625 127 23 0.71875 0.06161597499443527 0.06161597499443525 0.06161597499443529 0.30078125 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 AP1_control HSC_identity;log_library 8 4 0.061244773584269545 0.05263490240947309 -0.04191963513829771 0.1644091823068368 0.2109375 127 23 0.71875 -0.002233245523544785 -0.0022332455235448134 -0.002233245523544781 0.4296875 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08853409734685458 0.08533410148396194 -0.0787207415617108 0.25578893625542 0.2578125 127 23 0.71875 0.15695632719431568 0.15695632719431565 0.15695632719431568 0.5859375 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 HSC_retention HSC_identity;log_library 8 4 0.06076355270092972 0.02775928152000589 0.006355360921718178 0.11517174448014127 0.1953125 127 32 1.0 0.2516802445719431 0.251680244571943 0.2516802445719431 0.322265625 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.029930118126199237 0.010898942677067064 -0.05129204577325068 -0.00856819047914779 0.015625 127 32 1.0 -0.09423060754197264 -0.09423060754197264 -0.09423060754197259 0.171875 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03580585968593316 0.027320140415593625 -0.017741615528630343 0.08935333490049666 0.359375 127 32 1.0 0.02650758329230638 0.026507583292306375 0.026507583292306413 0.59296875 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.05470148252457918 0.03874615021356077 -0.021240971893999927 0.1306439369431583 0.203125 127 32 1.0 0.17449517544033102 0.174495175440331 0.17449517544033102 0.3723958333333333 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 AP1_control HSC_identity;log_library 8 4 0.06762426639027258 0.01808052987403491 0.03218642783716416 0.103062104943381 0.015625 127 32 1.0 0.12120386969672403 0.121203869696724 0.12120386969672407 0.1546875 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08344216240404387 0.036909887602691135 0.011098782702769247 0.15578554210531848 0.0390625 127 32 1.0 0.01824012573183815 0.018240125731838124 0.018240125731838176 0.1611328125 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 HSC_retention HSC_identity;log_library 8 4 0.004182427172188537 0.022299377566906076 -0.03952435285894737 0.047889207203324444 0.875 127 32 1.0 0.07493240069339538 0.07493240069339537 0.0749324006933954 0.90234375 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.003381868789688836 0.02332385619295181 -0.04233288934849671 0.049096626927874386 0.84375 127 32 1.0 0.12567554827538835 0.1256755482753883 0.12567554827538838 0.9564012096774194 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.005140369551406907 0.023266648120255196 -0.040462260764293274 0.050742999867107084 0.84375 127 32 1.0 0.07313034384278978 0.07313034384278976 0.07313034384278978 0.878173828125 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.0019380759403829586 0.02795836852047571 -0.056736478240515344 0.05286032635974943 0.96875 127 32 1.0 -0.023273716543762518 -0.02327371654376252 -0.023273716543762507 0.96875 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 AP1_control HSC_identity;log_library 8 4 -0.035585594824623513 0.025381866124854147 -0.08533405242933764 0.014162862780090615 0.125 127 32 1.0 0.049079538209811174 0.04907953820981117 0.04907953820981119 0.29464285714285715 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.004655446792405668 0.038594769623871754 -0.07099030167038298 0.0803011952551943 0.8828125 127 32 1.0 -0.03070781178005006 -0.03070781178005007 -0.030707811780050047 0.9397681451612904 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 HSC_retention HSC_identity;log_library 8 4 0.029778094620635034 0.03499217679943943 -0.038806571906266255 0.09836276114753632 0.3984375 127 29 0.90625 0.0633274565252049 0.06332745652520487 0.0633274565252049 0.5259375 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.023354934839317668 0.030628186718505663 -0.08338618080758876 0.036676311128953434 0.46875 127 29 0.90625 0.0742488644850514 0.07424886448505139 0.07424886448505143 0.8348214285714286 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.005952827537563268 0.04064823305118647 -0.07371770924276222 0.08562336431788875 0.90625 127 29 0.90625 0.1824143597319602 0.18241435973196019 0.18241435973196024 0.90625 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.052004596088561506 0.04310167894590131 -0.03247469464540506 0.13648388682252807 0.21875 127 29 0.90625 0.010835242891380882 0.010835242891380853 0.010835242891380896 0.37993421052631576 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 AP1_control HSC_identity;log_library 8 4 -0.05734161695004164 0.04286121673095459 -0.14134960174271263 0.02666636784262935 0.15625 127 29 0.90625 -0.12537301687125296 -0.125373016871253 -0.12537301687125293 0.34375 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.10600380313507418 0.05929259306778765 -0.01020967927778961 0.22221728554793796 0.1171875 127 29 0.90625 0.24265667167727425 0.24265667167727423 0.24265667167727428 0.322265625 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 HSC_retention HSC_identity;log_library 8 4 0.14647829153554742 0.030560933868652124 0.08657886115298927 0.20637772191810558 0.0078125 127 32 1.0 0.2754885757428729 0.2754885757428729 0.27548857574287294 0.04296875 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.002345441449160318 0.028736648180919474 -0.05866927188376248 0.05397838898544185 0.8984375 127 32 1.0 -0.13225608677903997 -0.13225608677904002 -0.13225608677903997 0.9564012096774194 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07183034275363864 0.03501628573599545 0.0031984227110875563 0.14046226279618973 0.125 127 32 1.0 0.17671638631095657 0.17671638631095654 0.1767163863109566 0.4125 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0588734912793208 0.028220641712706506 0.003561033522416053 0.11418594903622556 0.078125 127 32 1.0 0.00033358229454256283 0.00033358229454255177 0.0003335822945425846 0.3046875 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 AP1_control HSC_identity;log_library 8 4 0.13986579521512554 0.04040301443567216 0.06067588692120811 0.21905570350904296 0.078125 127 32 1.0 0.4841639889284753 0.4841639889284752 0.48416398892847534 0.234375 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.019384167849921516 0.033592048471132216 -0.04645624715349762 0.08522458285334066 0.359375 127 32 1.0 -0.2950192537851099 -0.29501925378511 -0.29501925378510985 0.5859375 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 HSC_retention HSC_identity;log_library 8 4 0.2747583626064844 0.0462021157616098 0.1842022157137292 0.3653145094992396 0.015625 127 32 1.0 0.15596828248806732 0.15596828248806732 0.15596828248806735 0.064453125 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.05313117271014735 0.019286027570274908 0.015330558672408526 0.09093178674788617 0.015625 127 32 1.0 -0.02850592010163234 -0.028505920101632345 -0.02850592010163232 0.171875 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.047509754234434494 0.04121317557715018 -0.03326806989677986 0.12828757836564886 0.15625 127 32 1.0 -0.03318926372234595 -0.03318926372234598 -0.033189263722345944 0.46875 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.03368065227716856 0.060812512498353184 -0.08551187221960369 0.1528731767739408 0.609375 127 32 1.0 -0.02568018599655091 -0.02568018599655091 -0.02568018599655089 0.837890625 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 AP1_control HSC_identity;log_library 8 4 0.1472330812113302 0.04708039308158635 0.054955510771420954 0.23951065165123941 0.0234375 127 32 1.0 0.1555900500714032 0.1555900500714032 0.15559005007140322 0.1546875 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.11564968669518562 0.04014584233539229 0.03696383571781672 0.19433553767255451 0.0234375 127 32 1.0 0.24218169105983542 0.2421816910598354 0.24218169105983545 0.1611328125 diff --git a/data/UQ_resolver_source_inputs/UQ_Visium_coupling_stage_trends.tsv b/data/UQ_resolver_source_inputs/UQ_Visium_coupling_stage_trends.tsv new file mode 100644 index 0000000..8c61bef --- /dev/null +++ b/data/UQ_resolver_source_inputs/UQ_Visium_coupling_stage_trends.tsv @@ -0,0 +1,7 @@ +outcome n_patients stage_beta_array_adjusted stage_beta_hc3_se stage_beta_hc3_p stage_beta_within_array_permutation_p spearman_rho spearman_p +AP1_control 32 0.027101807448414825 0.008064354956604987 0.000777476722865427 0.0031 0.576607859632287 0.0005518277021802511 +Endo_resolver 32 0.004867035945837325 0.005278949085285155 0.35654390230876665 0.2524 0.20782731865296922 0.25370715805456917 +HSC_retention 32 0.039816541436538455 0.011451005195562691 0.000506827250465214 0.0013 0.7718224696351212 2.3112443403278093e-07 +LAM_resolver 32 -0.005785458185001008 0.010937360088784457 0.5968311564344626 0.4499 0.03143764693391835 0.8643773195012645 +TGFb_integrator 32 0.0074258750898667635 0.006201728999463666 0.23115540854974026 0.3052 0.29517503228972447 0.10098297894972574 +retention_dominance 32 0.02361215809568971 0.007332180757293086 0.001280360162487862 0.0003 0.699534706625393 8.386872100168325e-06 diff --git a/data/UQ_resolver_source_inputs/UQ_Visium_mapping_audit.tsv b/data/UQ_resolver_source_inputs/UQ_Visium_mapping_audit.tsv new file mode 100644 index 0000000..165e316 --- /dev/null +++ b/data/UQ_resolver_source_inputs/UQ_Visium_mapping_audit.tsv @@ -0,0 +1,9 @@ +array matrix_barcodes mapped_spots unmapped_spots rescued_small_fragment_spots +VLP115_A 1744 1743 1 15 +VLP116_D 2173 2173 0 0 +VLP119_A 1691 1691 0 6 +VLP119_D 1277 1255 22 10 +VLP120_A 1884 1884 0 6 +VLP120_D 1657 1650 7 4 +VLP121_A 1530 1506 24 5 +VLP121_D 1683 1683 0 0 diff --git a/data/UQ_resolver_source_inputs/UQ_Visium_module_gene_mapping.json b/data/UQ_resolver_source_inputs/UQ_Visium_module_gene_mapping.json new file mode 100644 index 0000000..735e8f2 --- /dev/null +++ b/data/UQ_resolver_source_inputs/UQ_Visium_module_gene_mapping.json @@ -0,0 +1,95 @@ +{ + "ECM_scar": [ + "ACTA2", + "COL1A1", + "COL1A2", + "COL3A1", + "COL6A1", + "DCN", + "LOXL2", + "LUM", + "SPARC", + "TAGLN", + "THBS2", + "TIMP1" + ], + "HSC_identity": [ + "COL6A1", + "CSPG4", + "DES", + "NOTCH3", + "PDGFRB", + "RGS5" + ], + "Endo_identity": [ + "CDH5", + "EGFL7", + "ENG", + "ERG", + "PECAM1", + "RAMP2", + "ROBO4", + "TEK" + ], + "Myeloid_identity": [ + "AIF1", + "CD68", + "CTSS", + "FCER1G", + "LST1", + "SPI1", + "TYROBP" + ], + "HSC_retention": [ + "DPYSL3", + "EFEMP1", + "EPHA3", + "GAS7", + "ITGB5", + "LAMA2", + "LTBP2", + "PDGFRA", + "SERPINE1", + "SPON1", + "SVEP1" + ], + "Endo_resolver": [ + "ACE", + "EMCN", + "ESAM", + "KDR", + "KLF2", + "NR2F2", + "PLVAP", + "VWF", + "WNT7B", + "WNT9B" + ], + "LAM_resolver": [ + "AXL", + "CTSB", + "CTSD", + "GPNMB", + "LPL", + "MERTK", + "MMP14", + "TREM2" + ], + "AP1_control": [ + "FOS", + "FOSL1", + "FOSL2", + "JUN", + "JUNB", + "JUND" + ], + "TGFb_integrator": [ + "CCN2", + "SMAD3", + "SMAD7", + "TGFB1", + "TGFBR1", + "TGFBR2", + "THBS1" + ] +} diff --git a/data/UQ_resolver_source_inputs/UQ_Visium_module_mean_stage_trends.tsv b/data/UQ_resolver_source_inputs/UQ_Visium_module_mean_stage_trends.tsv new file mode 100644 index 0000000..f68b8ce --- /dev/null +++ b/data/UQ_resolver_source_inputs/UQ_Visium_module_mean_stage_trends.tsv @@ -0,0 +1,8 @@ +outcome n_patients stage_beta_array_adjusted stage_beta_hc3_se stage_beta_hc3_p stage_beta_within_array_permutation_p spearman_rho spearman_p +HSC_retention 32 0.09675051751828215 0.02599047782722376 0.00019723093042702704 0.0001 0.7400083239355273 1.2959294035406173e-06 +Endo_resolver 32 0.04176194347649522 0.012495774250910748 0.0008315150230512622 0.0001 0.5801845979062058 0.0005000462451512727 +LAM_resolver 32 0.06892520486205213 0.018650414486933647 0.00021933417615792173 0.0001 0.6455071337509344 6.623812415907434e-05 +retention_dominance 32 0.041406943349008504 0.01785133722653774 0.02036561530823395 0.0007 0.559477165794044 0.0008712277486373879 +AP1_control 32 0.04543236005106069 0.014085062856557787 0.0012572196729785526 0.0008 0.5805610966718815 0.000494853809796219 +TGFb_integrator 32 0.06602455408622859 0.017087687623677857 0.00011160595734716052 0.0001 0.6423068942426912 7.393631067981227e-05 +ECM_scar 32 0.178301378576188 0.04100973177721606 1.3752111655914544e-05 0.0001 0.7445263091236354 1.0301517936489046e-06 diff --git a/data/UQ_resolver_source_inputs/UQ_Visium_scar_threshold_sensitivity_coupling.tsv b/data/UQ_resolver_source_inputs/UQ_Visium_scar_threshold_sensitivity_coupling.tsv new file mode 100644 index 0000000..c674331 --- /dev/null +++ b/data/UQ_resolver_source_inputs/UQ_Visium_scar_threshold_sensitivity_coupling.tsv @@ -0,0 +1,595 @@ +biopsy_id patient_cluster array fibrosis_stage stage_numeric stage_group n_spots outcome covariates grid_long grid_cross beta beta_se beta_ci_low beta_ci_high spatial_field_p n_transforms n_blocks grid_occupancy residual_moran permuted_moran_min permuted_moran_max spatial_fdr_within_outcome scar_quantile +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 HSC_retention HSC_identity;log_library 8 4 0.0715358356450776 0.04027222745461346 -0.007397730165964789 0.15046940145611998 0.046875 127 32 1.0 -0.05520143021418519 -0.055201430214185214 -0.05520143021418517 0.11049107142857142 0.8 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.03683691607437156 0.054665115908474574 -0.0703067111062386 0.14398054325498172 0.4296875 127 32 1.0 0.056112808031404414 0.05611280803140439 0.056112808031404435 0.708984375 0.8 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04544129914099651 0.04085262111040172 -0.034629838235390856 0.12551243651738386 0.421875 127 32 1.0 -0.04653963502181695 -0.04653963502181696 -0.04653963502181693 0.580078125 0.8 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.028421971218941904 0.04361782568975293 -0.05706896713297383 0.11391290957085765 0.5703125 127 32 1.0 -0.2241192336107432 -0.22411923361074326 -0.22411923361074318 0.7352430555555556 0.8 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 AP1_control HSC_identity;log_library 8 4 -0.019692927438657706 0.0416314029150272 -0.10129047715211101 0.061904622274795595 0.6953125 127 32 1.0 0.1331705442486905 0.1331705442486905 0.13317054424869054 0.8089978448275862 0.8 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.06578646962352445 0.04115663052370618 -0.014880526202939656 0.14645346544998855 0.03125 127 32 1.0 -0.09382264616736254 -0.09382264616736256 -0.09382264616736254 0.12890625 0.8 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 HSC_retention HSC_identity;log_library 8 4 0.04952772356344451 0.02534131284280624 -0.00014124960845571938 0.09919669673534473 0.1953125 127 32 1.0 0.24327488543953749 0.24327488543953743 0.24327488543953757 0.30691964285714285 0.8 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.012760963322247737 0.0207606617630898 -0.02792993373340827 0.05345186037790374 0.5859375 127 32 1.0 -0.08040604317151455 -0.08040604317151456 -0.08040604317151452 0.7161458333333334 0.8 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.049063182827293585 0.04449688580278508 -0.13627707900075234 0.038150713346165176 0.265625 127 32 1.0 -0.1402082121460079 -0.14020821214600793 -0.1402082121460079 0.4869791666666667 0.8 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.018009745130930618 0.023725379171908145 -0.028491998046009343 0.06451148830787058 0.390625 127 32 1.0 -0.09936647896327314 -0.09936647896327315 -0.09936647896327311 0.7055921052631579 0.8 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 AP1_control HSC_identity;log_library 8 4 -0.0006896805075824532 0.02593331938307682 -0.05151898649841302 0.050139625483248115 0.9765625 127 32 1.0 -0.07783917775840343 -0.07783917775840343 -0.07783917775840342 0.9765625 0.8 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.06612030424683962 0.02958318179294057 0.008137267932676107 0.12410334056100314 0.03125 127 32 1.0 -0.20245197213629101 -0.20245197213629107 -0.20245197213629101 0.12890625 0.8 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 HSC_retention HSC_identity;log_library 8 4 0.06286039477655793 0.03656740289591919 -0.008811714899443684 0.13453250445255954 0.0859375 127 32 1.0 0.029774533871309673 0.029774533871309666 0.029774533871309683 0.16681985294117646 0.8 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.027853370701853872 0.02884498725167571 -0.028682804311430516 0.08438954571513826 0.328125 127 32 1.0 -0.20614846518837726 -0.20614846518837732 -0.20614846518837723 0.6015625 0.8 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.008641017096743505 0.030265218287503077 -0.050678810746762525 0.06796084494024954 0.796875 127 32 1.0 -0.29429692360148046 -0.2942969236014805 -0.29429692360148035 0.82177734375 0.8 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.05374418113323292 0.03362151187437468 -0.01215398214054144 0.11964234440700727 0.1015625 127 32 1.0 0.035733562511976465 0.03573356251197645 0.03573356251197648 0.33515625 0.8 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 AP1_control HSC_identity;log_library 8 4 0.020013940099469225 0.05437631536675728 -0.08656363801937503 0.1265915182183135 0.6015625 127 32 1.0 -0.28159213437006203 -0.28159213437006203 -0.281592134370062 0.7635216346153846 0.8 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.07979655125001145 0.034927649192498404 0.011338358832714585 0.14825474366730831 0.03125 127 32 1.0 0.2044461144124028 0.2044461144124028 0.20444611441240285 0.12890625 0.8 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 HSC_retention HSC_identity;log_library 8 4 -0.002697716914967082 0.032087549476843925 -0.06558931388958117 0.06019388005964701 0.953125 127 32 1.0 0.0885097286007272 0.08850972860072719 0.08850972860072721 0.953125 0.8 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.0189452305768357 0.027336489236692563 -0.07252474948075313 0.03463428832708172 0.53125 127 32 1.0 0.014539082874352564 0.014539082874352564 0.014539082874352594 0.7161458333333334 0.8 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.045120982234811355 0.03544363259481672 -0.024348537651029414 0.11459050212065212 0.2421875 127 32 1.0 -0.06950541049717364 -0.06950541049717364 -0.06950541049717361 0.4852941176470588 0.8 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.021587487228715098 0.026476023482064022 -0.07348049325356058 0.030305518796130387 0.3984375 127 32 1.0 0.20244849516750002 0.20244849516749996 0.20244849516750005 0.7055921052631579 0.8 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 AP1_control HSC_identity;log_library 8 4 0.05009471809913206 0.04384376805881451 -0.035839067296144375 0.13602850349440848 0.1796875 127 32 1.0 -0.20762487114368758 -0.2076248711436876 -0.20762487114368758 0.34880514705882354 0.8 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.033187931964681026 0.028607706819292783 -0.022883173401132828 0.08925903733049488 0.1796875 127 32 1.0 0.0247631098077852 0.02476310980778518 0.0247631098077852 0.37060546875 0.8 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 HSC_retention HSC_identity;log_library 8 4 0.2691934525506733 0.054915016017664915 0.16156002115605006 0.3768268839452965 0.0078125 127 27 0.84375 0.09684279808868701 0.09684279808868691 0.09684279808868702 0.028645833333333332 0.8 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.05777917385994918 0.03562586120847304 -0.012047514108657974 0.12760586182855632 0.1171875 127 27 0.84375 0.12199242153453166 0.12199242153453164 0.12199242153453169 0.4296875 0.8 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04030146715280994 0.07128540410907344 -0.09941792490097401 0.1800208592065939 0.515625 127 27 0.84375 0.06502994713538543 0.06502994713538542 0.06502994713538546 0.6353236607142857 0.8 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.16354380330796509 0.06560215468900794 0.034963580117509524 0.2921240264984206 0.015625 127 27 0.84375 -0.20477854499169468 -0.20477854499169468 -0.20477854499169462 0.171875 0.8 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 AP1_control HSC_identity;log_library 8 4 0.10480812304079168 0.05849701300710829 -0.009846022453140563 0.21946226853472392 0.15625 127 27 0.84375 0.025702417059866665 0.025702417059866655 0.025702417059866683 0.322265625 0.8 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.14259687002982513 0.06101248167639964 0.02301240594408184 0.26218133411556843 0.0234375 127 27 0.84375 0.0009116447341151603 0.0009116447341151394 0.0009116447341151859 0.12890625 0.8 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 HSC_retention HSC_identity;log_library 8 4 0.03989956142519741 0.035065559448451335 -0.02882893509376721 0.10862805794416203 0.4453125 127 32 1.0 0.19761815056289525 0.1976181505628952 0.19761815056289525 0.5442708333333334 0.8 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.008363743963200372 0.01812454717519381 -0.027160368500179492 0.04388785642658024 0.5234375 127 32 1.0 -0.3072255726093859 -0.3072255726093859 -0.30722557260938577 0.7161458333333334 0.8 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.041018111854573276 0.03269248928948268 -0.023059167152812775 0.10509539086195932 0.3046875 127 32 1.0 0.09470832326815946 0.09470832326815944 0.09470832326815948 0.49107142857142855 0.8 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.009498291713852317 0.026417920216262252 -0.042280831910021695 0.06127741533772633 0.71875 127 32 1.0 -0.061026644046925003 -0.06102664404692501 -0.06102664404692498 0.8470982142857143 0.8 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 AP1_control HSC_identity;log_library 8 4 0.03224778415543552 0.03615846130312386 -0.03862279999868725 0.10311836830955828 0.4296875 127 32 1.0 0.09658133844219285 0.09658133844219285 0.09658133844219287 0.64453125 0.8 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.005036748354821941 0.025863272377917804 -0.04565526550589695 0.055728762215540836 0.7890625 127 32 1.0 -0.16944845391110355 -0.16944845391110355 -0.16944845391110352 0.9375 0.8 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 HSC_retention HSC_identity;log_library 8 4 0.12827841069447585 0.028322692591345365 0.07276593321543894 0.18379088817351275 0.0078125 127 32 1.0 -0.03228242365831791 -0.032282423658317926 -0.032282423658317905 0.028645833333333332 0.8 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.0025022840716780047 0.02921685413134604 -0.05476275002576023 0.05976731816911624 0.9296875 127 32 1.0 -0.1125379905864636 -0.11253799058646363 -0.11253799058646356 0.9375 0.8 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04617013078067984 0.03462633255806835 -0.021697481033134132 0.11403774259449381 0.171875 127 32 1.0 0.059649141480478333 0.059649141480478306 0.05964914148047835 0.4362980769230769 0.8 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.07379825212995283 0.03379983223595529 0.00755058094748047 0.1400459233124252 0.046875 127 32 1.0 -0.015357487040276238 -0.015357487040276284 -0.015357487040276226 0.2864583333333333 0.8 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 AP1_control HSC_identity;log_library 8 4 0.08506610284569334 0.052705843433011636 -0.018237350283009462 0.18836955597439614 0.125 127 32 1.0 0.029145934916252524 0.029145934916252506 0.029145934916252555 0.322265625 0.8 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.01724423550023985 0.032715618615652746 -0.04687837698643954 0.08136684798691923 0.5546875 127 32 1.0 -0.15296675771235815 -0.15296675771235815 -0.15296675771235813 0.83203125 0.8 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 HSC_retention HSC_identity;log_library 8 4 0.02976783046669073 0.023813686381851114 -0.016906994841737452 0.07644265577511891 0.1640625 127 32 1.0 0.17446442613930607 0.17446442613930607 0.17446442613930607 0.28495065789473684 0.8 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.03473279243288737 0.01690812050501708 0.0015928762430538965 0.06787270862272085 0.0625 127 32 1.0 0.15124155623388846 0.15124155623388844 0.1512415562338885 0.36830357142857145 0.8 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.0321403718808415 0.026301712321890557 -0.01941098427006399 0.08369172803174699 0.171875 127 32 1.0 -0.22450161102120877 -0.22450161102120883 -0.22450161102120872 0.4362980769230769 0.8 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.016235792180941462 0.030024194208599565 -0.042611628467913686 0.0750832128297966 0.5234375 127 32 1.0 0.12443521816824854 0.12443521816824851 0.12443521816824854 0.7352430555555556 0.8 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 AP1_control HSC_identity;log_library 8 4 0.02824069408423151 0.025177055434176365 -0.021106334566754165 0.07758772273521719 0.3046875 127 32 1.0 -0.24688108635507078 -0.2468810863550708 -0.24688108635507075 0.502734375 0.8 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.009195921664664338 0.027454769405722224 -0.044615426370551214 0.0630072696998799 0.7265625 127 32 1.0 -0.29403843405663815 -0.29403843405663815 -0.29403843405663804 0.9221754807692307 0.8 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 HSC_retention HSC_identity;log_library 8 4 -0.0236034278351077 0.030108391826797736 -0.08261587581563126 0.03540902014541586 0.4765625 127 31 0.96875 0.08989785927268847 0.08989785927268844 0.08989785927268848 0.5616629464285714 0.8 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.01760747407651441 0.030821507617665733 -0.07801762900713924 0.042802680854110424 0.6171875 127 31 0.96875 -0.11566632668776308 -0.1156663266877631 -0.11566632668776303 0.7273995535714286 0.8 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.015319183021812715 0.024229333267854678 -0.03217031018318245 0.06280867622680789 0.59375 127 31 0.96875 -0.0454420554159561 -0.045442055415956126 -0.04544205541595608 0.653125 0.8 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.019398909344662495 0.0347627843722373 -0.08753396671424761 0.04873614802492261 0.5703125 127 31 0.96875 -0.10272728081020309 -0.10272728081020309 -0.10272728081020302 0.7352430555555556 0.8 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 AP1_control HSC_identity;log_library 8 4 -0.02824922438226551 0.038893525247088515 -0.104480533866559 0.04798208510202798 0.6640625 127 31 0.96875 0.12116074647509928 0.12116074647509928 0.12116074647509933 0.8089978448275862 0.8 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.003062418896834861 0.03636030104297402 -0.07432860894106394 0.0682037711473942 0.9375 127 31 0.96875 0.14236080083357391 0.14236080083357386 0.14236080083357394 0.9375 0.8 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 HSC_retention HSC_identity;log_library 8 4 0.2412230392849845 0.06135939099140503 0.12095863294183065 0.3614874456281384 0.015625 127 32 1.0 0.057045136261572496 0.057045136261572454 0.05704513626157251 0.039663461538461536 0.8 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.04460060498585383 0.037983005123191554 -0.11904729502730928 0.029846085055601615 0.234375 127 32 1.0 0.01903080076015159 0.01903080076015157 0.01903080076015159 0.515625 0.8 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07335667879769156 0.052246583344480416 -0.029046624557490047 0.17575998215287317 0.2265625 127 32 1.0 0.14347379862872486 0.14347379862872484 0.14347379862872486 0.4852941176470588 0.8 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.15117843602351538 0.047813496168274815 0.05746398353369675 0.24489288851333402 0.015625 127 32 1.0 -0.13771355158225954 -0.13771355158225956 -0.13771355158225948 0.171875 0.8 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 AP1_control HSC_identity;log_library 8 4 0.19120179340249213 0.04471823275689427 0.10355405719897935 0.2788495296060049 0.015625 127 32 1.0 0.2814646879200188 0.28146468792001866 0.2814646879200188 0.12890625 0.8 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08903343298414437 0.047129296973929015 -0.003339989084756495 0.18140685505304524 0.0703125 127 32 1.0 -0.024171391355007826 -0.02417139135500784 -0.024171391355007812 0.193359375 0.8 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 HSC_retention HSC_identity;log_library 8 4 0.018564284916313723 0.028697092730158243 -0.03768201683479644 0.07481058666742388 0.4453125 127 32 1.0 0.018284740233293177 0.01828474023329315 0.018284740233293205 0.5442708333333334 0.8 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.024102183075184667 0.017310857077153664 -0.05803146294640585 0.009827096796036511 0.15625 127 32 1.0 -0.0453280391465105 -0.04532803914651051 -0.0453280391465105 0.451171875 0.8 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.013263167655389764 0.02660962412231796 -0.06541803093513297 0.03889169562435344 0.5703125 127 32 1.0 -0.07620753611007038 -0.0762075361100704 -0.07620753611007036 0.6489762931034483 0.8 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.012151348595290873 0.02409510253425228 -0.0350750523718436 0.05937774956242534 0.5625 127 32 1.0 0.16873026262965543 0.16873026262965538 0.16873026262965546 0.7352430555555556 0.8 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 AP1_control HSC_identity;log_library 8 4 -0.03727652284380426 0.02198811302911858 -0.08037322438087668 0.0058201786932681535 0.140625 127 32 1.0 0.1297420591397895 0.12974205913978948 0.12974205913978953 0.322265625 0.8 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.01310054456951599 0.025587611295576667 -0.03705117356981428 0.06325226270884626 0.640625 127 32 1.0 -0.14554271893543605 -0.1455427189354361 -0.14554271893543605 0.9191576086956522 0.8 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 HSC_retention HSC_identity;log_library 8 4 -0.008238951917366956 0.02220587908618712 -0.05176247492629371 0.0352845710915598 0.6328125 127 32 1.0 0.011176941491978903 0.011176941491978891 0.01117694149197892 0.6736391129032258 0.8 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.026123790181240163 0.029803991712643384 -0.0845396139380212 0.03229203357554087 0.2734375 127 32 1.0 -0.30411849318042145 -0.30411849318042145 -0.3041184931804213 0.5307904411764706 0.8 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04011450654425584 0.055799327469088486 -0.06925217529515759 0.14948118838366928 0.359375 127 32 1.0 -0.11351560899839727 -0.11351560899839731 -0.11351560899839727 0.5380434782608695 0.8 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.018896929627684477 0.045395439100593696 -0.10787199026484812 0.07007813100947916 0.6015625 127 32 1.0 -0.10748946689971431 -0.10748946689971434 -0.10748946689971427 0.7352430555555556 0.8 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 AP1_control HSC_identity;log_library 8 4 -0.011276158229869564 0.05482157027863002 -0.11872643597598441 0.09617411951624528 0.8671875 127 32 1.0 0.031756965791358 0.03175696579135799 0.03175696579135802 0.9231350806451613 0.8 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.006129204977064855 0.05081257326126499 -0.09346343861501452 0.10572184856914424 0.8984375 127 32 1.0 -0.06501547336761469 -0.06501547336761469 -0.06501547336761468 0.9375 0.8 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 HSC_retention HSC_identity;log_library 8 4 0.15225934016753234 0.07892776686569154 -0.0024390828892230654 0.30695776322428775 0.1015625 127 32 1.0 0.018170268351886894 0.018170268351886877 0.0181702683518869 0.18619791666666666 0.8 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.07866113700068066 0.04557686061905344 -0.010669509812664082 0.1679917838140254 0.0625 127 32 1.0 -0.05035803088916444 -0.05035803088916446 -0.05035803088916443 0.36830357142857145 0.8 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.1096531374065874 0.05042012481658141 -0.20847658204708697 -0.010829692766087834 0.0625 127 32 1.0 0.08340887487013489 0.08340887487013487 0.0834088748701349 0.2578125 0.8 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.11288128333821303 0.0772135017941226 -0.03845718017826728 0.26421974685469335 0.1484375 127 32 1.0 -0.08829996692536138 -0.08829996692536142 -0.08829996692536138 0.408203125 0.8 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 AP1_control HSC_identity;log_library 8 4 0.097668456810974 0.05499340237831204 -0.0101186118505176 0.2054555254724656 0.1171875 127 32 1.0 -0.027856140626926307 -0.02785614062692633 -0.027856140626926294 0.322265625 0.8 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.09404291926504724 0.08071105151646199 -0.06415074170721827 0.25223658023731277 0.3515625 127 32 1.0 -0.04670274602541425 -0.04670274602541431 -0.04670274602541425 0.610608552631579 0.8 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 HSC_retention HSC_identity;log_library 8 4 -0.0025510515736057774 0.016899473695662783 -0.03567402001710483 0.030571916869893277 0.8671875 127 32 1.0 -0.205191464306162 -0.20519146430616206 -0.20519146430616197 0.894287109375 0.8 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.014418559457970341 0.024284178765939583 -0.06201554983921192 0.03317843092327124 0.515625 127 32 1.0 -0.14144196531882616 -0.14144196531882622 -0.14144196531882616 0.7161458333333334 0.8 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.05941398093814821 0.022502340570252074 0.015309393420454148 0.10351856845584227 0.0234375 127 32 1.0 -0.02198625332530103 -0.021986253325301058 -0.02198625332530102 0.193359375 0.8 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.022972343812218018 0.023939352873560214 -0.06989347544439603 0.02394878781996 0.3046875 127 32 1.0 -0.1862114236030661 -0.18621142360306614 -0.18621142360306606 0.6703125 0.8 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 AP1_control HSC_identity;log_library 8 4 -0.02202268034851279 0.04737972605585872 -0.11488694341799588 0.0708415827209703 0.7109375 127 32 1.0 0.22753564090958336 0.2275356409095833 0.22753564090958342 0.8089978448275862 0.8 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.011482429694174772 0.03617506090279691 -0.05942068967530717 0.08238554906365672 0.7109375 127 32 1.0 -0.13896161994541392 -0.13896161994541392 -0.13896161994541387 0.9221754807692307 0.8 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 HSC_retention HSC_identity;log_library 8 4 0.008840815848573358 0.020415722209717074 -0.031173999682472107 0.048855631379618826 0.5859375 127 28 0.875 0.029757503750501256 0.029757503750501242 0.029757503750501266 0.64453125 0.8 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.03452568098461923 0.03295814107814598 -0.09912363749778536 0.03007227552854689 0.21875 127 28 0.875 -0.08119721502105348 -0.08119721502105348 -0.08119721502105344 0.515625 0.8 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.09402413558711474 0.04022912562967431 0.015175049352953093 0.1728732218212764 0.015625 127 28 0.875 -0.04252754878726589 -0.04252754878726591 -0.042527548787265876 0.193359375 0.8 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.02075259996739833 0.025620693063180634 -0.07096915837123238 0.029463958436435712 0.40625 127 28 0.875 -0.06730378583106188 -0.06730378583106193 -0.06730378583106188 0.7055921052631579 0.8 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 AP1_control HSC_identity;log_library 8 4 0.01923638008674341 0.05681933872103793 -0.09212952380649092 0.13060228397997775 0.5859375 127 28 0.875 0.23441517759487274 0.23441517759487263 0.23441517759487274 0.7635216346153846 0.8 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.13826910695956293 0.05928583345374912 0.02206887339021467 0.2544693405289112 0.03125 127 28 0.875 0.04684001436071985 0.046840014360719835 0.04684001436071986 0.12890625 0.8 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 HSC_retention HSC_identity;log_library 8 4 0.06617819290887232 0.022360341887000982 0.022351922810350394 0.11000446300739425 0.0078125 127 30 0.9375 -0.17034092781296278 -0.1703409278129628 -0.17034092781296276 0.028645833333333332 0.8 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.01677623708696296 0.03349404251309801 -0.08242456041263506 0.04887208623870913 0.5859375 127 30 0.9375 0.2554494191625443 0.25544941916254427 0.2554494191625443 0.7161458333333334 0.8 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.11323310507892347 0.051828916840648796 0.011648428071251826 0.2148177820865951 0.046875 127 30 0.9375 -0.07967218492797938 -0.07967218492797938 -0.07967218492797937 0.22098214285714285 0.8 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.01101448811389467 0.03483887929021354 -0.05726971529492386 0.07929869152271321 0.6015625 127 30 0.9375 -0.13387954274375044 -0.13387954274375044 -0.13387954274375038 0.7352430555555556 0.8 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 AP1_control HSC_identity;log_library 8 4 0.07472378942585173 0.051401214855140404 -0.02602259169022346 0.17547017054192693 0.140625 127 30 0.9375 0.08030147313970132 0.0803014731397013 0.08030147313970132 0.322265625 0.8 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.10365439909700673 0.04167408208633829 0.02197319820778368 0.18533559998622978 0.0234375 127 30 0.9375 0.017703393777492204 0.017703393777492187 0.017703393777492204 0.12890625 0.8 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 HSC_retention HSC_identity;log_library 8 4 0.11091517247482673 0.030382433277435145 0.05136560325105384 0.1704647416985996 0.0078125 127 28 0.875 0.15095741299401755 0.15095741299401752 0.15095741299401758 0.028645833333333332 0.8 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.01944638257878159 0.046353250793654814 -0.11029875413434502 0.07140598897678184 0.5625 127 28 0.875 0.11421252057005657 0.11421252057005656 0.11421252057005657 0.7161458333333334 0.8 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.15330182573904144 0.05068441902363543 0.053960364452716 0.25264328702536687 0.0390625 127 28 0.875 0.06698621069177772 0.0669862106917777 0.06698621069177774 0.21484375 0.8 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0012337218732625809 0.042173669494042304 -0.08142667033506033 0.0838941140815855 0.9765625 127 28 0.875 0.18114360519248868 0.18114360519248865 0.1811436051924887 0.9765625 0.8 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 AP1_control HSC_identity;log_library 8 4 0.03193891994893653 0.06610959753121086 -0.09763589121223676 0.1615137311101098 0.484375 127 28 0.875 0.18390869627611078 0.18390869627611073 0.1839086962761108 0.6949728260869565 0.8 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.04277558695932019 0.05666167508624234 -0.06828129620971479 0.1538324701283552 0.4140625 127 28 0.875 -0.06685837558332568 -0.0668583755833257 -0.06685837558332566 0.683203125 0.8 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 HSC_retention HSC_identity;log_library 8 4 0.018300929366864914 0.023168484161837435 -0.027109299590336457 0.06371115832406629 0.359375 127 32 1.0 0.01570788942384098 0.015707889423840958 0.015707889423840982 0.5048828125 0.8 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.01165980451075536 0.030615155912637304 -0.04834590107801376 0.07166551009952447 0.703125 127 32 1.0 -0.05582858408753578 -0.05582858408753579 -0.05582858408753576 0.8001077586206896 0.8 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.0017565071588781886 0.03894356664149857 -0.07808589777621538 0.074572883458459 0.953125 127 32 1.0 -0.0995891780149854 -0.09958917801498543 -0.09958917801498539 0.953125 0.8 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.016032558282316603 0.031238221776114662 -0.04519435639886813 0.07725947296350133 0.578125 127 32 1.0 0.07081131105129998 0.07081131105129997 0.07081131105130001 0.7352430555555556 0.8 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 AP1_control HSC_identity;log_library 8 4 0.07733126754407596 0.034293175822851144 0.010116642931287723 0.1445458921568642 0.0546875 127 32 1.0 0.04988246134583721 0.049882461345837195 0.04988246134583722 0.20052083333333334 0.8 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.0527946414417936 0.02765714080066375 -0.0014133545275073559 0.10700263741109456 0.0859375 127 32 1.0 0.1030838313437641 0.10308383134376407 0.1030838313437641 0.21814903846153846 0.8 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 HSC_retention HSC_identity;log_library 8 4 0.08892737243717742 0.0396370847259872 0.011238686374242524 0.16661605850011232 0.0546875 127 32 1.0 0.13839135290998805 0.13839135290998805 0.1383913529099881 0.1203125 0.8 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.019411812484287503 0.024455287167414477 -0.06734417533241988 0.028520550363844873 0.375 127 32 1.0 0.03668778517589933 0.03668778517589932 0.03668778517589937 0.6513157894736842 0.8 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.05857558406541229 0.03866434970062163 -0.01720654134780611 0.13435770947863068 0.1484375 127 32 1.0 -0.032303166516465864 -0.03230316651646587 -0.03230316651646585 0.4362980769230769 0.8 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.05533292890768984 0.0350730450135478 -0.013410239318863842 0.12407609713424353 0.078125 127 32 1.0 -0.12812198700309074 -0.1281219870030908 -0.12812198700309074 0.2864583333333333 0.8 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 AP1_control HSC_identity;log_library 8 4 0.10032012326553523 0.03980966694235372 0.022293176058521935 0.17834707047254852 0.046875 127 32 1.0 0.017736406973762303 0.017736406973762286 0.01773640697376233 0.193359375 0.8 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.03118736855236233 0.03194652244158354 -0.03142781543314141 0.09380255253786607 0.2734375 127 32 1.0 -0.024199711431415638 -0.024199711431415687 -0.02419971143141563 0.5013020833333334 0.8 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 HSC_retention HSC_identity;log_library 8 4 0.3164606548423387 0.0786070119001934 0.16239091151795965 0.47053039816671777 0.015625 127 32 1.0 0.08585848413681957 0.08585848413681955 0.0858584841368196 0.039663461538461536 0.8 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.06552210301430617 0.06258214260882955 -0.18818310252761208 0.05713889649899975 0.25 127 32 1.0 0.058716715993704066 0.05871671599370405 0.05871671599370408 0.515625 0.8 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.09085762208985311 0.07560167854139745 -0.05732166785128588 0.2390369120309921 0.3125 127 32 1.0 -0.011807624449517586 -0.011807624449517592 -0.01180762444951757 0.49107142857142855 0.8 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.1366928440839083 0.06885948738397611 0.0017282488113151417 0.27165743935650144 0.0625 127 32 1.0 0.10102763071359354 0.10102763071359351 0.10102763071359354 0.2864583333333333 0.8 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 AP1_control HSC_identity;log_library 8 4 0.20618725311616387 0.06503699328281318 0.07871474628185005 0.3336597599504777 0.0078125 127 32 1.0 0.09279974948781122 0.09279974948781118 0.09279974948781124 0.12890625 0.8 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.14064869381288225 0.09865899185313944 -0.05272293021927105 0.33402031784503555 0.1171875 127 32 1.0 -0.25033680371837386 -0.2503368037183739 -0.2503368037183738 0.2578125 0.8 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 HSC_retention HSC_identity;log_library 8 4 0.05340853821135279 0.046922217835667454 -0.03855900874655542 0.14537608516926098 0.40625 127 31 0.96875 0.13509986131016913 0.13509986131016913 0.13509986131016913 0.53625 0.8 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.08209756432881289 0.0348299701626587 0.013830822810001836 0.15036430584762395 0.078125 127 31 0.96875 -0.0721925292420094 -0.0721925292420094 -0.07219252924200938 0.36830357142857145 0.8 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.024704263294641763 0.053619149134428695 -0.08038926900883848 0.12979779559812202 0.5390625 127 31 0.96875 -0.04593654478014189 -0.04593654478014191 -0.04593654478014187 0.6353236607142857 0.8 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.013376985898332633 0.06572787170074876 -0.11544964263513494 0.1422036144318002 0.8671875 127 31 0.96875 0.08115780642763798 0.08115780642763797 0.08115780642763801 0.9397681451612904 0.8 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 AP1_control HSC_identity;log_library 8 4 0.041982347265836904 0.06760287332904429 -0.09051928445908988 0.1744839789907637 0.5234375 127 31 0.96875 -0.10664519443268608 -0.1066451944326861 -0.10664519443268602 0.7197265625 0.8 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.0657155521627981 0.045402118921581844 -0.023272600923502307 0.15470370524909852 0.09375 127 31 0.96875 -0.002458467634290003 -0.002458467634290003 -0.0024584676342899884 0.22098214285714285 0.8 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 HSC_retention HSC_identity;log_library 8 4 0.20671868449859873 0.0482229049991754 0.11220179070021495 0.3012355782969825 0.0078125 127 32 1.0 0.12306534885901009 0.12306534885901005 0.12306534885901015 0.028645833333333332 0.8 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.005313099613045639 0.03047091784981556 -0.05440989937259286 0.06503609859868413 0.78125 127 32 1.0 -0.13866590233553752 -0.13866590233553755 -0.1386659023355375 0.8316532258064516 0.8 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.08469617412926893 0.04681593749537799 -0.007063063361671937 0.17645541162020978 0.03125 127 32 1.0 0.05612353997967021 0.056123539979670206 0.05612353997967027 0.20625 0.8 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.12323101401087347 0.041096143739079515 0.04268257228227762 0.20377945573946932 0.0390625 127 32 1.0 -0.008373890254363045 -0.008373890254363057 -0.008373890254363036 0.2864583333333333 0.8 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 AP1_control HSC_identity;log_library 8 4 0.0005623048263679991 0.027021786729638394 -0.05240039716372325 0.053525006816459254 0.9765625 127 32 1.0 0.20206895441235587 0.20206895441235587 0.20206895441235587 0.9765625 0.8 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.029139744439307926 0.03697376237529494 -0.043328829816270155 0.10160831869488601 0.203125 127 32 1.0 0.048428768522343305 0.0484287685223433 0.04842876852234332 0.3943014705882353 0.8 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 HSC_retention HSC_identity;log_library 8 4 0.12462419623888547 0.04093038452291053 0.04440064257398084 0.20484774990379012 0.015625 127 32 1.0 0.15905591844550115 0.15905591844550115 0.15905591844550118 0.039663461538461536 0.8 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.040673991372944626 0.026315128610819777 -0.010903660704262137 0.09225164345015138 0.1640625 127 32 1.0 0.1015073383288384 0.10150733832883839 0.10150733832883843 0.451171875 0.8 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.03172871814142145 0.04516117978039386 -0.12024463051099342 0.056787194228150525 0.5390625 127 32 1.0 0.04357768231708645 0.043577682317086426 0.04357768231708649 0.6353236607142857 0.8 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.07085761191629404 0.034481457328833724 0.00327395555177995 0.13844126828080813 0.078125 127 32 1.0 -0.03185353835691802 -0.03185353835691804 -0.031853538356918 0.2864583333333333 0.8 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 AP1_control HSC_identity;log_library 8 4 0.05487721004194139 0.04431368512849733 -0.031977612809913375 0.14173203289379616 0.2421875 127 32 1.0 0.09862138205823726 0.09862138205823724 0.09862138205823727 0.4440104166666667 0.8 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.07665564433776295 0.027929648162111985 0.02191353394002346 0.13139775473550244 0.046875 127 32 1.0 -0.028402602144766084 -0.028402602144766104 -0.028402602144766084 0.140625 0.8 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 HSC_retention HSC_identity;log_library 8 4 0.04130120635749349 0.041439531919988004 -0.039920276205682996 0.12252268892066998 0.2421875 127 32 1.0 -0.010813071116433277 -0.010813071116433315 -0.010813071116433277 0.36328125 0.8 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.04595743670599084 0.029835048970042823 -0.012519259275293092 0.10443413268727478 0.15625 127 32 1.0 0.06410818414671017 0.06410818414671014 0.06410818414671018 0.451171875 0.8 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.13271599878315962 0.04155953427227233 0.05125931160950585 0.21417268595681338 0.0078125 127 32 1.0 -0.042385522751944106 -0.04238552275194415 -0.042385522751944106 0.193359375 0.8 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.05703504844797087 0.05495183365140882 -0.16474064240473216 0.05067054550879042 0.1875 127 32 1.0 -0.0014100615616928565 -0.0014100615616928728 -0.0014100615616928398 0.47596153846153844 0.8 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 AP1_control HSC_identity;log_library 8 4 0.17625967348711294 0.05697155099327848 0.06459543354028711 0.28792391343393875 0.0234375 127 32 1.0 0.2670361943061338 0.2670361943061338 0.2670361943061338 0.12890625 0.8 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.003857090787654785 0.05068374224941477 -0.09548304402119817 0.10319722559650774 0.921875 127 32 1.0 0.026955897551989908 0.026955897551989894 0.02695589755198994 0.9375 0.8 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 HSC_retention HSC_identity;log_library 8 4 0.03351250000408352 0.023790475894717476 -0.013116832749562733 0.08014183275772976 0.078125 127 32 1.0 -0.08702342782848987 -0.08702342782848989 -0.08702342782848985 0.1611328125 0.8 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.035507673801715 0.017027593714219275 0.002133590121845226 0.06888175748158479 0.015625 127 32 1.0 -0.04961124989517849 -0.04961124989517852 -0.04961124989517847 0.2578125 0.8 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.020073968319031535 0.02502919241367666 -0.02898324881177472 0.06913118544983779 0.375 127 32 1.0 0.222842622712775 0.22284262271277494 0.222842622712775 0.5380434782608695 0.8 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.0021452424278093148 0.028542328356221155 -0.05808820600600278 0.05379772115038415 0.9609375 127 32 1.0 -0.008618912272155128 -0.008618912272155149 -0.008618912272155107 0.9765625 0.8 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 AP1_control HSC_identity;log_library 8 4 0.031250282293440644 0.022641397313444715 -0.013126856440910994 0.07562742102779228 0.1484375 127 32 1.0 -0.24138999504935577 -0.24138999504935582 -0.2413899950493557 0.322265625 0.8 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.005369299740859312 0.022446699502084423 -0.038626231283226155 0.04936483076494478 0.7265625 127 32 1.0 0.004832249745234888 0.004832249745234883 0.004832249745234909 0.9221754807692307 0.8 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 HSC_retention HSC_identity;log_library 8 4 0.37118709655545673 0.04598478749995751 0.28105691305554004 0.4613172800553734 0.0078125 127 32 1.0 0.12391633997598447 0.12391633997598447 0.12391633997598452 0.028645833333333332 0.8 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.07569830127253033 0.03790331497935191 0.001407803913000577 0.14998879863206008 0.1171875 127 32 1.0 0.01950872495383079 0.01950872495383079 0.0195087249538308 0.4296875 0.8 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.13486501799100592 0.04954257816580118 0.03776156478603561 0.23196847119597624 0.0234375 127 32 1.0 0.03641023914486489 0.036410239144864874 0.03641023914486491 0.193359375 0.8 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.19230076551196545 0.046684311240836426 0.10079951547992606 0.28380201554400486 0.0078125 127 32 1.0 0.0777491809710572 0.07774918097105715 0.07774918097105724 0.171875 0.8 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 AP1_control HSC_identity;log_library 8 4 0.2519122347744464 0.055337706615094 0.1434503298088622 0.36037413974003063 0.0078125 127 32 1.0 0.03550518222142226 0.03550518222142224 0.03550518222142226 0.12890625 0.8 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.15681470272901543 0.037193771786313036 0.08391491002784188 0.229714495430189 0.0078125 127 32 1.0 0.22733000976866444 0.2273300097686644 0.2273300097686645 0.12890625 0.8 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 HSC_retention HSC_identity;log_library 8 4 0.21367653093529526 0.06782921546186536 0.08073126863003915 0.34662179324055137 0.0078125 127 32 1.0 0.25502862202070825 0.25502862202070814 0.2550286220207083 0.028645833333333332 0.8 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.09163387821185143 0.03815753466687009 0.016845110264786065 0.16642264615891678 0.0703125 127 32 1.0 0.08855276980698538 0.08855276980698537 0.08855276980698541 0.36830357142857145 0.8 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.05381403648879542 0.04245632884166551 -0.029400368040868978 0.13702844101845982 0.140625 127 32 1.0 0.19291234154817988 0.19291234154817985 0.19291234154817996 0.4362980769230769 0.8 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.05693513515887989 0.06404860795535953 -0.0686001364336248 0.1824704067513846 0.375 127 32 1.0 0.12310193438767511 0.1231019343876751 0.12310193438767514 0.7055921052631579 0.8 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 AP1_control HSC_identity;log_library 8 4 0.04984577182646793 0.05257484192865891 -0.053200918353703525 0.1528924620066394 0.3984375 127 32 1.0 -0.017898282644803035 -0.017898282644803063 -0.01789828264480303 0.6261160714285714 0.8 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.024385621704670773 0.03877775605973554 -0.05161878017241088 0.10039002358175243 0.4375 127 32 1.0 -0.13543470281436593 -0.13543470281436598 -0.1354347028143659 0.6875 0.8 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 HSC_retention HSC_identity;log_library 8 4 0.24356445534843885 0.05142320359762631 0.1427749762970913 0.3443539343997864 0.0078125 127 23 0.71875 -0.017525861600573983 -0.017525861600573997 -0.01752586160057397 0.028645833333333332 0.8 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.03320198651255307 0.02648317195308362 -0.08510900354059697 0.01870503051549082 0.1796875 127 23 0.71875 0.10832503669450172 0.1083250366945017 0.10832503669450173 0.4561298076923077 0.8 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.10500421678631808 0.07539811412194664 -0.042776086892697324 0.2527845204653335 0.234375 127 23 0.71875 0.267762377664109 0.26776237766410893 0.267762377664109 0.4852941176470588 0.8 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.1459876353038071 0.06550322129543944 0.01760132156474581 0.2743739490428684 0.0625 127 23 0.71875 0.06161597499443527 0.06161597499443525 0.06161597499443529 0.2864583333333333 0.8 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 AP1_control HSC_identity;log_library 8 4 0.05403619591045148 0.052392867511932416 -0.04865382441293605 0.156726216233839 0.2578125 127 23 0.71875 -0.002233245523544785 -0.0022332455235448134 -0.002233245523544781 0.4477796052631579 0.8 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.016996732849034614 0.08740332476203427 -0.15431378368455256 0.18830724938262178 0.796875 127 23 0.71875 0.15695632719431568 0.15695632719431565 0.15695632719431568 0.9375 0.8 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 HSC_retention HSC_identity;log_library 8 4 0.05947845832116366 0.0279358304877508 0.0047242305651720995 0.11423268607715523 0.1953125 127 32 1.0 0.2516802445719431 0.251680244571943 0.2516802445719431 0.30691964285714285 0.8 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.029239093974392345 0.01102560972096853 -0.05084928902749067 -0.007628898921294026 0.015625 127 32 1.0 -0.09423060754197264 -0.09423060754197264 -0.09423060754197259 0.2578125 0.8 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03762841490309019 0.027172911541045917 -0.015630491717359807 0.09088732152354019 0.3125 127 32 1.0 0.02650758329230638 0.026507583292306375 0.026507583292306413 0.49107142857142855 0.8 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.050321344984057485 0.03896273438199607 -0.02604561440465481 0.1266883043727698 0.234375 127 32 1.0 0.17449517544033102 0.174495175440331 0.17449517544033102 0.5524553571428571 0.8 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 AP1_control HSC_identity;log_library 8 4 0.06485604968847901 0.018502616611805793 0.028590921129339655 0.10112117824761836 0.015625 127 32 1.0 0.12120386969672403 0.121203869696724 0.12120386969672407 0.12890625 0.8 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08203313937108168 0.03694208904628139 0.009626644840370152 0.15443963390179322 0.0390625 127 32 1.0 0.01824012573183815 0.018240125731838124 0.018240125731838176 0.12890625 0.8 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 HSC_retention HSC_identity;log_library 8 4 0.012526904916823333 0.0216634382330041 -0.029933434019864702 0.054987243853511364 0.5390625 127 32 1.0 0.07493240069339538 0.07493240069339537 0.0749324006933954 0.6134159482758621 0.8 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.013811090333872796 0.022663386811045412 -0.030609147815776214 0.058231328483521805 0.5390625 127 32 1.0 0.12567554827538835 0.1256755482753883 0.12567554827538838 0.7161458333333334 0.8 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.010150227071290038 0.022732289420962875 -0.0344050601937972 0.05470551433637727 0.7578125 127 32 1.0 0.07313034384278978 0.07313034384278976 0.07313034384278978 0.8067036290322581 0.8 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.002386505578542266 0.027417773026820687 -0.05612534071111081 0.05135232955402628 0.8828125 127 32 1.0 -0.023273716543762518 -0.02327371654376252 -0.023273716543762507 0.9397681451612904 0.8 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 AP1_control HSC_identity;log_library 8 4 -0.038354693895094286 0.024598925474406844 -0.08656858782493171 0.00985920003474313 0.140625 127 32 1.0 0.049079538209811174 0.04907953820981117 0.04907953820981119 0.322265625 0.8 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.006060169448489799 0.037805377999794616 -0.08015871032808725 0.06803837143110764 0.84375 127 32 1.0 -0.03070781178005006 -0.03070781178005007 -0.030707811780050047 0.9375 0.8 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 HSC_retention HSC_identity;log_library 8 4 0.03776707948193457 0.04134875304648484 -0.04327647648917571 0.11881063545304485 0.3671875 127 29 0.90625 0.0633274565252049 0.06332745652520487 0.0633274565252049 0.5048828125 0.8 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.00431476050285083 0.03664272466179969 -0.07613450083997823 0.06750497983427657 0.9375 127 29 0.90625 0.0742488644850514 0.07424886448505139 0.07424886448505143 0.9375 0.8 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.05076417646050277 0.04766041525611554 -0.04265023744148369 0.14417859036248923 0.25 127 29 0.90625 0.1824143597319602 0.18241435973196019 0.18241435973196024 0.4852941176470588 0.8 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.017296283903622412 0.05343230830163811 -0.08743104036758828 0.1220236081748331 0.765625 127 29 0.90625 0.010835242891380882 0.010835242891380853 0.010835242891380896 0.8712284482758621 0.8 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 AP1_control HSC_identity;log_library 8 4 -0.013483877172452934 0.05247171396018028 -0.11632843653440628 0.08936068218950041 0.796875 127 29 0.90625 -0.12537301687125296 -0.125373016871253 -0.12537301687125293 0.8765625 0.8 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.15473080925006874 0.06879721643781568 0.019888265031950014 0.28957335346818747 0.0390625 127 29 0.90625 0.24265667167727425 0.24265667167727423 0.24265667167727428 0.12890625 0.8 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 HSC_retention HSC_identity;log_library 8 4 0.18446509067884903 0.04014092848049138 0.10578887085708592 0.2631413105006121 0.015625 127 32 1.0 0.2754885757428729 0.2754885757428729 0.27548857574287294 0.039663461538461536 0.8 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.011387969133960051 0.040162596764238306 -0.06733072052394704 0.09010665879186713 0.734375 127 32 1.0 -0.13225608677903997 -0.13225608677904002 -0.13225608677903997 0.8078125 0.8 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.056422265679336184 0.051802973567829674 -0.04511156251360998 0.15795609387228235 0.4765625 127 32 1.0 0.17671638631095657 0.17671638631095654 0.1767163863109566 0.6290625 0.8 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.06139300546130923 0.04463754340596991 -0.026096579614391796 0.14888259053701025 0.140625 127 32 1.0 0.00033358229454256283 0.00033358229454255177 0.0003335822945425846 0.408203125 0.8 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 AP1_control HSC_identity;log_library 8 4 0.21055205232652024 0.04787426369335405 0.11671849548754631 0.3043856091654942 0.0234375 127 32 1.0 0.4841639889284753 0.4841639889284752 0.48416398892847534 0.12890625 0.8 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.0032821659353442787 0.04751495960384093 -0.08984715488818394 0.0964114867588725 0.921875 127 32 1.0 -0.2950192537851099 -0.29501925378511 -0.29501925378510985 0.9375 0.8 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 HSC_retention HSC_identity;log_library 8 4 0.2869898615857577 0.04881182235774009 0.1913186897645871 0.38266103340692825 0.0078125 127 32 1.0 0.15596828248806732 0.15596828248806732 0.15596828248806735 0.028645833333333332 0.8 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.03948532969985904 0.020219151542439483 -0.00014420732332234842 0.07911486672304043 0.0703125 127 32 1.0 -0.02850592010163234 -0.028505920101632345 -0.02850592010163232 0.36830357142857145 0.8 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.0709986043308643 0.042277982874041865 -0.011866242102257757 0.15386345076398636 0.15625 127 32 1.0 -0.03318926372234595 -0.03318926372234598 -0.033189263722345944 0.4362980769230769 0.8 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.04485663941285743 0.06019907582707421 -0.07313354920820803 0.1628468280339229 0.4453125 127 32 1.0 -0.02568018599655091 -0.02568018599655091 -0.02568018599655089 0.734765625 0.8 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 AP1_control HSC_identity;log_library 8 4 0.1536182124425185 0.049531747182099 0.05653598796560447 0.25070043691943256 0.03125 127 32 1.0 0.1555900500714032 0.1555900500714032 0.15559005007140322 0.14732142857142858 0.8 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.10913198919353904 0.043508112492545034 0.023856088708150786 0.1944078896789273 0.0234375 127 32 1.0 0.24218169105983542 0.2421816910598354 0.24218169105983545 0.12890625 0.8 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 HSC_retention HSC_identity;log_library 8 4 0.045551593003391434 0.0349917361331341 -0.023032209817551406 0.11413539582433427 0.1484375 127 32 1.0 -0.05520143021418519 -0.055201430214185214 -0.05520143021418517 0.2578125 0.85 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.014614826069207033 0.04870092321367915 -0.0808389834296041 0.11006863556801816 0.703125 127 32 1.0 0.056112808031404414 0.05611280803140439 0.056112808031404435 0.9420072115384616 0.85 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.064557305940759 0.03607671851620713 -0.006153062351006988 0.13526767423252498 0.2109375 127 32 1.0 -0.04653963502181695 -0.04653963502181696 -0.04653963502181693 0.48125 0.85 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.002676765353541949 0.04142551196163284 -0.07851723809125842 0.08387076879834231 0.953125 127 32 1.0 -0.2241192336107432 -0.22411923361074326 -0.22411923361074318 0.96875 0.85 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 AP1_control HSC_identity;log_library 8 4 0.014434638476568673 0.03535031744471849 -0.05485198371507957 0.08372126066821692 0.734375 127 32 1.0 0.1331705442486905 0.1331705442486905 0.13317054424869054 0.8067036290322581 0.85 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.030429184212686707 0.03888828868744562 -0.04579186161470671 0.10665023004008012 0.3125 127 32 1.0 -0.09382264616736254 -0.09382264616736256 -0.09382264616736254 0.5859375 0.85 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 HSC_retention HSC_identity;log_library 8 4 0.042723623808867045 0.01940894974826254 0.004682082302272468 0.08076516531546163 0.1328125 127 32 1.0 0.24327488543953749 0.24327488543953743 0.24327488543953757 0.24348958333333334 0.85 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.012197731519341169 0.016066977185440687 -0.019293543764122574 0.043689006802804915 0.515625 127 32 1.0 -0.08040604317151455 -0.08040604317151456 -0.08040604317151452 0.8348214285714286 0.85 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.0077506859367681615 0.036611789679989896 -0.07950979370954835 0.06400842183601203 0.8515625 127 32 1.0 -0.1402082121460079 -0.14020821214600793 -0.1402082121460079 0.878173828125 0.85 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.0018581945428374055 0.01930583044876689 -0.039697622222420514 0.0359812331367457 0.8828125 127 32 1.0 -0.09936647896327314 -0.09936647896327315 -0.09936647896327311 0.96875 0.85 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 AP1_control HSC_identity;log_library 8 4 0.00781300179265517 0.020126107588030046 -0.031634169079883714 0.047260172665194056 0.7109375 127 32 1.0 -0.07783917775840343 -0.07783917775840343 -0.07783917775840342 0.8067036290322581 0.85 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.035090495743759574 0.02504706793304103 -0.014001757405000842 0.08418274889251999 0.1171875 127 32 1.0 -0.20245197213629101 -0.20245197213629107 -0.20245197213629101 0.322265625 0.85 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 HSC_retention HSC_identity;log_library 8 4 0.04539840145679032 0.03274517086740676 -0.018782133443326937 0.10957893635690757 0.109375 127 32 1.0 0.029774533871309673 0.029774533871309666 0.029774533871309683 0.24169921875 0.85 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.019166049936537196 0.025241823095824907 -0.03030792333127962 0.06864002320435401 0.3984375 127 32 1.0 -0.20614846518837726 -0.20614846518837732 -0.20614846518837723 0.8348214285714286 0.85 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.005582615944080646 0.026549976977920463 -0.05762057082080475 0.04645533893264346 0.8203125 127 32 1.0 -0.29429692360148046 -0.2942969236014805 -0.29429692360148035 0.878173828125 0.85 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0410135833464663 0.02955154948485106 -0.016907453643841774 0.09893462033677437 0.078125 127 32 1.0 0.035733562511976465 0.03573356251197645 0.03573356251197648 0.3046875 0.85 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 AP1_control HSC_identity;log_library 8 4 -0.022129810238871218 0.04780640517238363 -0.11583036437674313 0.0715707438990007 0.5390625 127 32 1.0 -0.28159213437006203 -0.28159213437006203 -0.281592134370062 0.6841947115384616 0.85 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.035234655936845445 0.03275326794356736 -0.02896174923254658 0.09943106110623748 0.4296875 127 32 1.0 0.2044461144124028 0.2044461144124028 0.20444611441240285 0.6165081521739131 0.85 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 HSC_retention HSC_identity;log_library 8 4 0.0020825576090289706 0.03158413233503148 -0.059822341767632736 0.06398745698569068 0.9296875 127 32 1.0 0.0885097286007272 0.08850972860072719 0.08850972860072721 0.9296875 0.85 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.0006858008933042782 0.02716667656777449 -0.05256088517953372 0.05393248696614228 0.96875 127 32 1.0 0.014539082874352564 0.014539082874352564 0.014539082874352594 0.96875 0.85 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.06595452622073765 0.032931146205751494 0.0014094796574647267 0.1304995727840106 0.0546875 127 32 1.0 -0.06950541049717364 -0.06950541049717364 -0.06950541049717361 0.2578125 0.85 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.0401989273415837 0.024780625125021962 -0.08876895258662675 0.008371097903459343 0.125 127 32 1.0 0.20244849516750002 0.20244849516749996 0.20244849516750005 0.3265625 0.85 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 AP1_control HSC_identity;log_library 8 4 0.07537944137270418 0.04178691886166098 -0.006522919596151339 0.1572818023415597 0.03125 127 32 1.0 -0.20762487114368758 -0.2076248711436876 -0.20762487114368758 0.171875 0.85 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.05609359235304392 0.026212906465421536 0.00471629568081771 0.10747088902527013 0.03125 127 32 1.0 0.0247631098077852 0.02476310980778518 0.0247631098077852 0.1611328125 0.85 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 HSC_retention HSC_identity;log_library 8 4 0.25394422856573934 0.052293648937591954 0.1514486766480591 0.35643978048341957 0.0078125 127 27 0.84375 0.09684279808868701 0.09684279808868691 0.09684279808868702 0.04296875 0.85 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.056373441522112794 0.03362308206277427 -0.009527799320924776 0.12227468236515036 0.1015625 127 27 0.84375 0.12199242153453166 0.12199242153453164 0.12199242153453169 0.4583333333333333 0.85 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.1441901292556238 0.07712636757386193 -0.006977551189145587 0.29535780970039316 0.1015625 127 27 0.84375 0.06502994713538543 0.06502994713538542 0.06502994713538546 0.4125 0.85 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.12166590940838191 0.08638491017580348 -0.04764851453619291 0.29098033335295675 0.1015625 127 27 0.84375 -0.20477854499169468 -0.20477854499169468 -0.20477854499169462 0.3046875 0.85 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 AP1_control HSC_identity;log_library 8 4 0.14073095756510356 0.051393968548852406 0.03999877920935285 0.24146313592085428 0.0390625 127 27 0.84375 0.025702417059866665 0.025702417059866655 0.025702417059866683 0.18415178571428573 0.85 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.19506530316725967 0.06696130498031351 0.06382114540584519 0.3263094609286742 0.0078125 127 27 0.84375 0.0009116447341151603 0.0009116447341151394 0.0009116447341151859 0.0859375 0.85 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 HSC_retention HSC_identity;log_library 8 4 0.040135947946452304 0.03506221908545866 -0.028586001461046666 0.10885789735395127 0.4375 127 32 1.0 0.19761815056289525 0.1976181505628952 0.19761815056289525 0.5552884615384616 0.85 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.008124296991316572 0.018119364946621534 -0.027389658304061634 0.04363825228669478 0.53125 127 32 1.0 -0.3072255726093859 -0.3072255726093859 -0.30722557260938577 0.8348214285714286 0.85 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.041137016439404005 0.03268971197547946 -0.022934819032535726 0.10520885191134374 0.296875 127 32 1.0 0.09470832326815946 0.09470832326815944 0.09470832326815948 0.55859375 0.85 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.009693151691134294 0.02639277848009138 -0.04203669412984481 0.06142299751211339 0.703125 127 32 1.0 -0.061026644046925003 -0.06102664404692501 -0.06102664404692498 0.8924278846153846 0.85 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 AP1_control HSC_identity;log_library 8 4 0.03319349239126153 0.03613426916606919 -0.03762967517423409 0.10401665995675714 0.4140625 127 32 1.0 0.09658133844219285 0.09658133844219285 0.09658133844219287 0.5693359375 0.85 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.006260665269631513 0.02585543398638962 -0.04441598534369214 0.05693731588295516 0.7734375 127 32 1.0 -0.16944845391110355 -0.16944845391110355 -0.16944845391110352 0.8801185344827587 0.85 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 HSC_retention HSC_identity;log_library 8 4 0.11552777974307435 0.025276110035549075 0.06598660407339815 0.16506895541275055 0.0078125 127 32 1.0 -0.03228242365831791 -0.032282423658317926 -0.032282423658317905 0.04296875 0.85 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.002850547776737138 0.026547950348390338 -0.04918343490610793 0.0548845304595822 0.9453125 127 32 1.0 -0.1125379905864636 -0.11253799058646363 -0.11253799058646356 0.96875 0.85 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03949582673440876 0.0314766838160216 -0.02219847354499358 0.10119012701381111 0.1953125 127 32 1.0 0.059649141480478333 0.059649141480478306 0.05964914148047835 0.48125 0.85 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.06573321969284993 0.031157003399306923 0.004665493030208356 0.1268009463554915 0.0546875 127 32 1.0 -0.015357487040276238 -0.015357487040276284 -0.015357487040276226 0.30078125 0.85 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 AP1_control HSC_identity;log_library 8 4 0.08085414543948549 0.04694233079178748 -0.011152822912417967 0.17286111379138897 0.1015625 127 32 1.0 0.029145934916252524 0.029145934916252506 0.029145934916252555 0.2578125 0.85 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.018236989663940828 0.0295790300265709 -0.03973790918813814 0.07621188851601979 0.53125 127 32 1.0 -0.15296675771235815 -0.15296675771235815 -0.15296675771235813 0.73046875 0.85 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 HSC_retention HSC_identity;log_library 8 4 0.025430129196932688 0.025252425155407272 -0.024064624107665564 0.07492488250153094 0.34375 127 32 1.0 0.17446442613930607 0.17446442613930607 0.17446442613930607 0.47265625 0.85 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.022121837804279804 0.018701685625862004 -0.014533466022409725 0.05877714163096934 0.1953125 127 32 1.0 0.15124155623388846 0.15124155623388844 0.1512415562338885 0.5859375 0.85 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.031220848978912207 0.027043328093083595 -0.021784074083531637 0.08422577204135605 0.203125 127 32 1.0 -0.22450161102120877 -0.22450161102120883 -0.22450161102120872 0.48125 0.85 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.014930867232385804 0.030466747012275683 -0.044783956911674534 0.07464569137644614 0.640625 127 32 1.0 0.12443521816824854 0.12443521816824851 0.12443521816824854 0.845625 0.85 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 AP1_control HSC_identity;log_library 8 4 0.029930576120712354 0.02643877394226618 -0.02188942080612936 0.08175057304755406 0.3046875 127 32 1.0 -0.24688108635507078 -0.2468810863550708 -0.24688108635507075 0.502734375 0.85 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.01320465040691624 0.0280930276905937 -0.041857683866647406 0.06826698468047988 0.5859375 127 32 1.0 -0.29403843405663815 -0.29403843405663815 -0.29403843405663804 0.7734375 0.85 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 HSC_retention HSC_identity;log_library 8 4 -0.02393612068259545 0.03168839997889434 -0.08604538464122835 0.038173143276037456 0.5078125 127 31 0.96875 0.08989785927268847 0.08989785927268844 0.08989785927268848 0.6206597222222222 0.85 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.0069495666038062644 0.03243343053711131 -0.07051909045654443 0.05661995724893191 0.828125 127 31 0.96875 -0.11566632668776308 -0.1156663266877631 -0.11566632668776303 0.9564012096774194 0.85 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.017677855384916497 0.025435682499349816 -0.03217608231380914 0.06753179308364214 0.609375 127 31 0.96875 -0.0454420554159561 -0.045442055415956126 -0.04544205541595608 0.804375 0.85 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.028623453214789523 0.036175918515616655 -0.09952825350539816 0.04228134707581911 0.4453125 127 31 0.96875 -0.10272728081020309 -0.10272728081020309 -0.10272728081020302 0.6997767857142857 0.85 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 AP1_control HSC_identity;log_library 8 4 -0.03807345596711975 0.04064438959263335 -0.11773645956868112 0.041589547634441615 0.5 127 31 0.96875 0.12116074647509928 0.12116074647509928 0.12116074647509933 0.66 0.85 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.0004162616470475496 0.03823592175591369 -0.0753586682886384 0.07452614499454328 0.9921875 127 31 0.96875 0.14236080083357391 0.14236080083357386 0.14236080083357394 0.9921875 0.85 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 HSC_retention HSC_identity;log_library 8 4 0.07036436058598704 0.07233029491032951 -0.07140301743825879 0.21213173861023288 0.2265625 127 32 1.0 0.057045136261572496 0.057045136261572454 0.05704513626157251 0.33984375 0.85 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.01977219439962935 0.03311445870808572 -0.08467653346747736 0.04513214466821866 0.6171875 127 32 1.0 0.01903080076015159 0.01903080076015157 0.01903080076015159 0.92578125 0.85 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.020237747532291437 0.05014672030939066 -0.11852531933869712 0.07804982427411425 0.734375 127 32 1.0 0.14347379862872486 0.14347379862872484 0.14347379862872486 0.878173828125 0.85 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.05279620484018888 0.047308836207315186 -0.03992911412614888 0.14552152380652664 0.1484375 127 32 1.0 -0.13771355158225954 -0.13771355158225956 -0.13771355158225948 0.3265625 0.85 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 AP1_control HSC_identity;log_library 8 4 0.09464316392341063 0.052341137382219106 -0.007945465345738825 0.19723179319256007 0.0546875 127 32 1.0 0.2814646879200188 0.28146468792001866 0.2814646879200188 0.20052083333333334 0.85 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.017134415698623687 0.046488625199835494 -0.07398328969305389 0.10825212109030126 0.7109375 127 32 1.0 -0.024171391355007826 -0.02417139135500784 -0.024171391355007812 0.8689236111111112 0.85 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 HSC_retention HSC_identity;log_library 8 4 0.05233191905451619 0.02675585608956458 -0.00010955888103039019 0.10477339699006277 0.1171875 127 32 1.0 0.018284740233293177 0.01828474023329315 0.018284740233293205 0.24169921875 0.85 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.017587920520838858 0.016443871816434426 -0.04981790928105033 0.014642068239372613 0.2421875 127 32 1.0 -0.0453280391465105 -0.04532803914651051 -0.0453280391465105 0.6077008928571429 0.85 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.011869024031637613 0.024737654664437152 -0.036616779110659206 0.060354827173934436 0.671875 127 32 1.0 -0.07620753611007038 -0.0762075361100704 -0.07620753611007036 0.8527644230769231 0.85 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.04463049565230387 0.02043072649174972 0.004586271728474416 0.08467471957613332 0.09375 127 32 1.0 0.16873026262965543 0.16873026262965538 0.16873026262965546 0.3046875 0.85 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 AP1_control HSC_identity;log_library 8 4 -0.02273248067139559 0.02237234259351012 -0.06658227215467542 0.02111731081188424 0.3828125 127 32 1.0 0.1297420591397895 0.12974205913978948 0.12974205913978953 0.5604619565217391 0.85 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.017087875794343833 0.023667354170604626 -0.029300138380041234 0.0634758899687289 0.328125 127 32 1.0 -0.14554271893543605 -0.1455427189354361 -0.14554271893543605 0.5859375 0.85 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 HSC_retention HSC_identity;log_library 8 4 0.003576069181105665 0.020255325864692628 -0.036124369513691884 0.04327650787590322 0.859375 127 32 1.0 0.011176941491978903 0.011176941491978891 0.01117694149197892 0.90234375 0.85 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.031858297968872844 0.026841075509505333 -0.08446680596750329 0.020750210029757604 0.125 127 32 1.0 -0.30411849318042145 -0.30411849318042145 -0.3041184931804213 0.4583333333333333 0.85 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.034035355333707044 0.04990807046464832 -0.06378446277700367 0.13185517344441774 0.46875 127 32 1.0 -0.11351560899839727 -0.11351560899839731 -0.11351560899839727 0.73046875 0.85 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0018870291568179852 0.04065362365999825 -0.07779407321677859 0.08156813153041456 0.9609375 127 32 1.0 -0.10748946689971431 -0.10748946689971434 -0.10748946689971427 0.96875 0.85 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 AP1_control HSC_identity;log_library 8 4 -0.04224144883478804 0.049307007338346066 -0.13888318321794632 0.05440028554837025 0.3828125 127 32 1.0 0.031756965791358 0.03175696579135799 0.03175696579135802 0.5604619565217391 0.85 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.00814068510770496 0.04539025654888984 -0.09710558794352905 0.08082421772811912 0.921875 127 32 1.0 -0.06501547336761469 -0.06501547336761469 -0.06501547336761468 0.95068359375 0.85 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 HSC_retention HSC_identity;log_library 8 4 0.15119910860666586 0.08490118383886935 -0.015207211717518071 0.31760542893084975 0.1328125 127 32 1.0 0.018170268351886894 0.018170268351886877 0.0181702683518869 0.24348958333333334 0.85 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.08515768127019027 0.04815975759547705 -0.009235443616944741 0.17955080615732527 0.0703125 127 32 1.0 -0.05035803088916444 -0.05035803088916446 -0.05035803088916443 0.38671875 0.85 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.10602732899725505 0.054138226746994256 -0.21213825342136378 8.359542685369703e-05 0.125 127 32 1.0 0.08340887487013489 0.08340887487013487 0.0834088748701349 0.4125 0.85 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.11180463475144307 0.08164560158165611 -0.04822074434860289 0.271830013851489 0.1484375 127 32 1.0 -0.08829996692536138 -0.08829996692536142 -0.08829996692536138 0.3265625 0.85 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 AP1_control HSC_identity;log_library 8 4 0.11743801729738362 0.05773657672470698 0.004274326916957949 0.2306017076778093 0.078125 127 32 1.0 -0.027856140626926307 -0.02785614062692633 -0.027856140626926294 0.234375 0.85 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.11549624480001601 0.0846862579757132 -0.05048882083238186 0.28148131043241387 0.296875 127 32 1.0 -0.04670274602541425 -0.04670274602541431 -0.04670274602541425 0.5859375 0.85 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 HSC_retention HSC_identity;log_library 8 4 -0.009518008485339515 0.01948045789843221 -0.047699705966266645 0.02866368899558762 0.625 127 32 1.0 -0.205191464306162 -0.20519146430616206 -0.20519146430616197 0.7112068965517241 0.85 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.0220036775061633 0.028670975910274052 -0.034191435277973845 0.07819879029030044 0.421875 127 32 1.0 -0.14144196531882616 -0.14144196531882622 -0.14144196531882616 0.8348214285714286 0.85 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07397207612606556 0.028131808121931175 0.018833732207080456 0.12911042004505066 0.0078125 127 32 1.0 -0.02198625332530103 -0.021986253325301058 -0.02198625332530102 0.21484375 0.85 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.06177091776381282 0.028200715201918327 -0.11704431955957274 -0.006497515968052897 0.0390625 127 32 1.0 -0.1862114236030661 -0.18621142360306614 -0.18621142360306606 0.30078125 0.85 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 AP1_control HSC_identity;log_library 8 4 -0.0222644813485011 0.054875894327316245 -0.12982123423004094 0.08529227153303873 0.6875 127 32 1.0 0.22753564090958336 0.2275356409095833 0.22753564090958342 0.8067036290322581 0.85 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08926447725701454 0.04188510703920754 0.00716966746016777 0.17135928705386133 0.03125 127 32 1.0 -0.13896161994541392 -0.13896161994541392 -0.13896161994541387 0.1611328125 0.85 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 HSC_retention HSC_identity;log_library 8 4 -0.013094626632936675 0.02334011174136567 -0.05884124564601339 0.03265199238014004 0.578125 127 28 0.875 0.029757503750501256 0.029757503750501242 0.029757503750501266 0.6813616071428571 0.85 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.022437833278889364 0.038648106052301415 -0.09818812114140013 0.05331245458362141 0.5078125 127 28 0.875 -0.08119721502105348 -0.08119721502105348 -0.08119721502105344 0.8348214285714286 0.85 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.06679662955195548 0.04907954992377132 -0.02939928829863632 0.16299254740254726 0.21875 127 28 0.875 -0.04252754878726589 -0.04252754878726591 -0.042527548787265876 0.48125 0.85 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.03759167577936354 0.02889005456536994 -0.09421618272748862 0.019032831168761546 0.1484375 127 28 0.875 -0.06730378583106188 -0.06730378583106193 -0.06730378583106188 0.3265625 0.85 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 AP1_control HSC_identity;log_library 8 4 0.020539828914729552 0.06514945218982134 -0.10715309737732026 0.14823275520677937 0.7578125 127 28 0.875 0.23441517759487274 0.23441517759487263 0.23441517759487274 0.8067036290322581 0.85 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.19166111781122155 0.06364760837167194 0.06691180540274456 0.31641043021969856 0.0078125 127 28 0.875 0.04684001436071985 0.046840014360719835 0.04684001436071986 0.0859375 0.85 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 HSC_retention HSC_identity;log_library 8 4 0.0310434256921454 0.020374222383505388 -0.008890050179525159 0.07097690156381596 0.09375 127 30 0.9375 -0.17034092781296278 -0.1703409278129628 -0.17034092781296276 0.23798076923076922 0.85 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.02698594093499492 0.02610150867873847 -0.07814489794532233 0.024173016075332482 0.2578125 127 30 0.9375 0.2554494191625443 0.25544941916254427 0.2554494191625443 0.6077008928571429 0.85 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.10349001750664481 0.042324341061556074 0.020534309025994915 0.1864457259872947 0.03125 127 30 0.9375 -0.07967218492797938 -0.07967218492797938 -0.07967218492797937 0.21484375 0.85 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.02015250479113733 0.027728802505581553 -0.07450095770207718 0.03419594811980251 0.2890625 127 30 0.9375 -0.13387954274375044 -0.13387954274375044 -0.13387954274375038 0.476953125 0.85 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 AP1_control HSC_identity;log_library 8 4 0.05487739408726364 0.0426233084094133 -0.028664290395186434 0.1384190785697137 0.2265625 127 30 0.9375 0.08030147313970132 0.0803014731397013 0.08030147313970132 0.4296875 0.85 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.0742085222440832 0.03581881765739005 0.004003639635598702 0.1444134048525677 0.0390625 127 30 0.9375 0.017703393777492204 0.017703393777492187 0.017703393777492204 0.1611328125 0.85 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 HSC_retention HSC_identity;log_library 8 4 0.09749356678754201 0.026147015998001486 0.046245415431459096 0.1487417181436249 0.03125 127 28 0.875 0.15095741299401755 0.15095741299401752 0.15095741299401758 0.103125 0.85 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.020478152918664592 0.03930314731072857 -0.09751232164769259 0.056556015810363416 0.53125 127 28 0.875 0.11421252057005657 0.11421252057005656 0.11421252057005657 0.8348214285714286 0.85 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.1374384300183248 0.044199093740583104 0.0508082062867819 0.22406865374986767 0.0390625 127 28 0.875 0.06698621069177772 0.0669862106917777 0.06698621069177774 0.21484375 0.85 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.00983681337506254 0.035958633012103884 -0.06064210732866107 0.08031573407878614 0.828125 127 28 0.875 0.18114360519248868 0.18114360519248865 0.1811436051924887 0.9423491379310345 0.85 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 AP1_control HSC_identity;log_library 8 4 -0.010811334789618857 0.05756667035105355 -0.12364200867768381 0.10201933909844609 0.84375 127 28 0.875 0.18390869627611078 0.18390869627611073 0.1839086962761108 0.84375 0.85 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.035108005302720575 0.049889245998157396 -0.06267491685366791 0.13289092745910908 0.3359375 127 28 0.875 -0.06685837558332568 -0.0668583755833257 -0.06685837558332566 0.5859375 0.85 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 HSC_retention HSC_identity;log_library 8 4 -0.015676401767745072 0.01799856760275582 -0.050953594269146474 0.019600790733656333 0.2109375 127 32 1.0 0.01570788942384098 0.015707889423840958 0.015707889423840982 0.3314732142857143 0.85 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.011824158294976787 0.023795833632044343 -0.034815675623830124 0.0584639922137837 0.7265625 127 32 1.0 -0.05582858408753578 -0.05582858408753579 -0.05582858408753576 0.9420072115384616 0.85 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.025567442323167117 0.029834728175158646 -0.03290862490014383 0.08404350954647806 0.25 127 32 1.0 -0.0995891780149854 -0.09958917801498543 -0.09958917801498539 0.515625 0.85 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.03487596419904598 0.02327843909487418 -0.08050170482499938 0.010749776426907408 0.09375 127 32 1.0 0.07081131105129998 0.07081131105129997 0.07081131105130001 0.3046875 0.85 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 AP1_control HSC_identity;log_library 8 4 0.05930471552139824 0.02677620268237873 0.00682335826393593 0.11178607277886055 0.046875 127 32 1.0 0.04988246134583721 0.049882461345837195 0.04988246134583722 0.193359375 0.85 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.009612247103119713 0.022801859991805142 -0.03507939848081837 0.05430389268705779 0.7421875 127 32 1.0 0.1030838313437641 0.10308383134376407 0.1030838313437641 0.8747209821428571 0.85 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 HSC_retention HSC_identity;log_library 8 4 0.04642028203870064 0.032375458963464124 -0.01703561752968904 0.10987618160709031 0.1171875 127 32 1.0 0.13839135290998805 0.13839135290998805 0.1383913529099881 0.24169921875 0.85 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.004528574265365727 0.018341761826838027 -0.0314212789152368 0.04047842744596826 0.8671875 127 32 1.0 0.03668778517589933 0.03668778517589932 0.03668778517589937 0.9564012096774194 0.85 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04009998662224662 0.030322989664053612 -0.01933307311929846 0.0995330463637917 0.3046875 127 32 1.0 -0.032303166516465864 -0.03230316651646587 -0.03230316651646585 0.55859375 0.85 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.01636540659192577 0.027067386997794686 -0.036686671923751815 0.06941748510760336 0.546875 127 32 1.0 -0.12812198700309074 -0.1281219870030908 -0.12812198700309074 0.8203125 0.85 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 AP1_control HSC_identity;log_library 8 4 0.051549829159739484 0.032943692799889665 -0.013019808728044265 0.11611946704752324 0.2890625 127 32 1.0 0.017736406973762303 0.017736406973762286 0.01773640697376233 0.5020559210526315 0.85 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.01942980696023377 0.024975603345183964 -0.029522375596326797 0.06838198951679433 0.390625 127 32 1.0 -0.024199711431415638 -0.024199711431415687 -0.02419971143141563 0.5859375 0.85 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 HSC_retention HSC_identity;log_library 8 4 0.2706307667520711 0.06434877773154207 0.14450716239824862 0.39675437110589357 0.0078125 127 32 1.0 0.08585848413681957 0.08585848413681955 0.0858584841368196 0.04296875 0.85 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.020909647055406298 0.05502282327378512 -0.08693508656121253 0.12875438067202513 0.7421875 127 32 1.0 0.058716715993704066 0.05871671599370405 0.05871671599370408 0.9420072115384616 0.85 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03519533920942061 0.06451532170941174 -0.0912546913410264 0.16164536975986762 0.53125 127 32 1.0 -0.011807624449517586 -0.011807624449517592 -0.01180762444951757 0.73046875 0.85 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.08505413847325326 0.06077271422786831 -0.03406038141336863 0.20416865835987513 0.171875 127 32 1.0 0.10102763071359354 0.10102763071359351 0.10102763071359354 0.3544921875 0.85 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 AP1_control HSC_identity;log_library 8 4 0.17155389669237944 0.054128318500327295 0.06546239243173795 0.2776454009530209 0.0234375 127 32 1.0 0.09279974948781122 0.09279974948781118 0.09279974948781124 0.1546875 0.85 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.06362858808315669 0.08464359428684347 -0.1022728567190565 0.22953003288536988 0.3828125 127 32 1.0 -0.25033680371837386 -0.2503368037183739 -0.2503368037183738 0.5859375 0.85 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 HSC_retention HSC_identity;log_library 8 4 0.06634224139816879 0.04768987394715995 -0.027129911538264717 0.1598143943346023 0.296875 127 31 0.96875 0.13509986131016913 0.13509986131016913 0.13509986131016913 0.42595108695652173 0.85 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.06830994378012964 0.03671853782949648 -0.003658390365683467 0.14027827792594275 0.1171875 127 31 0.96875 -0.0721925292420094 -0.0721925292420094 -0.07219252924200938 0.4583333333333333 0.85 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.028892109472407702 0.055743595103364935 -0.08036533693018758 0.13814955587500297 0.515625 127 31 0.96875 -0.04593654478014189 -0.04593654478014191 -0.04593654478014187 0.73046875 0.85 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.032755478377958246 0.06768642295680397 -0.09990991061737753 0.16542086737329403 0.734375 127 31 0.96875 0.08115780642763798 0.08115780642763797 0.08115780642763801 0.8975694444444444 0.85 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 AP1_control HSC_identity;log_library 8 4 0.07155664212074696 0.06860713857574167 -0.06291334948770673 0.20602663372920066 0.234375 127 31 0.96875 -0.10664519443268608 -0.1066451944326861 -0.10664519443268602 0.4296875 0.85 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.044586121340701494 0.04833396532317697 -0.05014845069272537 0.13932069337412836 0.328125 127 31 0.96875 -0.002458467634290003 -0.002458467634290003 -0.0024584676342899884 0.5859375 0.85 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 HSC_retention HSC_identity;log_library 8 4 0.19835606200459355 0.04277185437723463 0.11452322742521368 0.2821888965839734 0.0078125 127 32 1.0 0.12306534885901009 0.12306534885901005 0.12306534885901015 0.04296875 0.85 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.003409985491638526 0.028415971309893085 -0.05228531827575192 0.05910528925902897 0.890625 127 32 1.0 -0.13866590233553752 -0.13866590233553755 -0.1386659023355375 0.9564012096774194 0.85 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.08919783084304961 0.043678982243214884 0.0035870256463484407 0.17480863603975078 0.0390625 127 32 1.0 0.05612353997967021 0.056123539979670206 0.05612353997967027 0.21484375 0.85 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.11410739046309945 0.03836186815044101 0.03891812888823508 0.1892966520379638 0.046875 127 32 1.0 -0.008373890254363045 -0.008373890254363057 -0.008373890254363036 0.30078125 0.85 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 AP1_control HSC_identity;log_library 8 4 0.0038314857818226144 0.02475264499891815 -0.04468369841605696 0.05234666997970219 0.828125 127 32 1.0 0.20206895441235587 0.20206895441235587 0.20206895441235587 0.84375 0.85 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.03001268745523916 0.03492981517772109 -0.03844975029309418 0.0984751252035725 0.359375 127 32 1.0 0.048428768522343305 0.0484287685223433 0.04842876852234332 0.5859375 0.85 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 HSC_retention HSC_identity;log_library 8 4 0.11423915984508663 0.04316438543492844 0.02963696439262689 0.19884135529754637 0.0390625 127 32 1.0 0.15905591844550115 0.15905591844550115 0.15905591844550118 0.1171875 0.85 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.030450254932993703 0.02703432064404871 -0.02253701352934177 0.08343752339532917 0.25 127 32 1.0 0.1015073383288384 0.10150733832883839 0.10150733832883843 0.6077008928571429 0.85 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.01606115897372698 0.047165435436090794 -0.10850541242846494 0.07638309448101098 0.828125 127 32 1.0 0.04357768231708645 0.043577682317086426 0.04357768231708649 0.878173828125 0.85 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0502416065616474 0.036810283280952594 -0.021906548669019685 0.12238976179231449 0.1953125 127 32 1.0 -0.03185353835691802 -0.03185353835691804 -0.031853538356918 0.3723958333333333 0.85 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 AP1_control HSC_identity;log_library 8 4 0.04353185603076303 0.04577975304473147 -0.04619645993691065 0.1332601719984367 0.390625 127 32 1.0 0.09862138205823726 0.09862138205823724 0.09862138205823727 0.5604619565217391 0.85 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08961958057812612 0.02785323066703682 0.03502724847073395 0.1442119126855183 0.0078125 127 32 1.0 -0.028402602144766084 -0.028402602144766104 -0.028402602144766084 0.0859375 0.85 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 HSC_retention HSC_identity;log_library 8 4 -0.01223661117018496 0.03551881399527296 -0.08185348660091996 0.05738026426055004 0.671875 127 32 1.0 -0.010813071116433277 -0.010813071116433315 -0.010813071116433277 0.7390625 0.85 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.05017424027929221 0.02521893474062343 0.0007451281876702867 0.09960335237091414 0.0625 127 32 1.0 0.06410818414671017 0.06410818414671014 0.06410818414671018 0.38671875 0.85 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.10316936543283771 0.03975346585077587 0.025252572365317014 0.18108615850035842 0.03125 127 32 1.0 -0.042385522751944106 -0.04238552275194415 -0.042385522751944106 0.21484375 0.85 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.11578534269638031 0.0464027505414765 -0.20673473375767426 -0.024835951635086367 0.03125 127 32 1.0 -0.0014100615616928565 -0.0014100615616928728 -0.0014100615616928398 0.30078125 0.85 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 AP1_control HSC_identity;log_library 8 4 0.1418267229319079 0.04883407248246946 0.046111940866267756 0.23754150499754806 0.0234375 127 32 1.0 0.2670361943061338 0.2670361943061338 0.2670361943061338 0.1546875 0.85 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.007681729670227766 0.04615089878387437 -0.082774031946166 0.09813749128662153 0.828125 127 32 1.0 0.026955897551989908 0.026955897551989894 0.02695589755198994 0.9109375 0.85 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 HSC_retention HSC_identity;log_library 8 4 0.03736570982885237 0.02263458626015497 -0.006998079241051364 0.08172949889875611 0.0625 127 32 1.0 -0.08702342782848987 -0.08702342782848989 -0.08702342782848985 0.171875 0.85 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.03305616922981936 0.016535266026107234 0.000647047818649181 0.06546529064098955 0.015625 127 32 1.0 -0.04961124989517849 -0.04961124989517852 -0.04961124989517847 0.171875 0.85 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.012522864302471832 0.024207725477208574 -0.03492427763285697 0.05997000623780064 0.53125 127 32 1.0 0.222842622712775 0.22284262271277494 0.222842622712775 0.73046875 0.85 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.007859652388093784 0.027428649066043902 -0.04590049978135226 0.061619804557539834 0.796875 127 32 1.0 -0.008618912272155128 -0.008618912272155149 -0.008618912272155107 0.9391741071428571 0.85 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 AP1_control HSC_identity;log_library 8 4 0.033260169976854256 0.02164112022329973 -0.009156425660813212 0.07567676561452172 0.0859375 127 32 1.0 -0.24138999504935577 -0.24138999504935582 -0.2413899950493557 0.236328125 0.85 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.006041574175582712 0.021553479301400405 -0.03620324525516208 0.0482863936063275 0.6328125 127 32 1.0 0.004832249745234888 0.004832249745234883 0.004832249745234909 0.8031850961538461 0.85 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 HSC_retention HSC_identity;log_library 8 4 0.19215060918230165 0.042872104618239974 0.1081212841305513 0.27617993423405196 0.015625 127 32 1.0 0.12391633997598447 0.12391633997598447 0.12391633997598452 0.064453125 0.85 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.013366953977135724 0.026136517792175566 -0.037860620895528385 0.06459452884979983 0.6484375 127 32 1.0 0.01950872495383079 0.01950872495383079 0.0195087249538308 0.9303668478260869 0.85 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.08771229522410545 0.030751065447681858 0.02744020694664901 0.1479843835015619 0.0234375 127 32 1.0 0.03641023914486489 0.036410239144864874 0.03641023914486491 0.21484375 0.85 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.09008691539227204 0.032165117110249504 0.027043285856183014 0.15313054492836106 0.0234375 127 32 1.0 0.0777491809710572 0.07774918097105715 0.07774918097105724 0.30078125 0.85 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 AP1_control HSC_identity;log_library 8 4 0.12532855165536191 0.04277779373455758 0.041484075935629056 0.20917302737509477 0.0078125 127 32 1.0 0.03550518222142226 0.03550518222142224 0.03550518222142226 0.1546875 0.85 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.06750126224877907 0.027087618474366783 0.01440953003902018 0.12059299445853797 0.078125 127 32 1.0 0.22733000976866444 0.2273300097686644 0.2273300097686645 0.2578125 0.85 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 HSC_retention HSC_identity;log_library 8 4 0.15131950194088467 0.061234508152305495 0.031299865962365905 0.27133913791940345 0.03125 127 32 1.0 0.25502862202070825 0.25502862202070814 0.2550286220207083 0.103125 0.85 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.06983762096789999 0.0339287507906103 0.003337269418303798 0.1363379725174962 0.0703125 127 32 1.0 0.08855276980698538 0.08855276980698537 0.08855276980698541 0.38671875 0.85 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.010046133472308656 0.03838721484728826 -0.08528507457299364 0.06519280762837634 0.7890625 127 32 1.0 0.19291234154817988 0.19291234154817985 0.19291234154817996 0.878173828125 0.85 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.02904388811735228 0.05734164263771301 -0.08334573145256521 0.14143350768726978 0.5859375 127 32 1.0 0.12310193438767511 0.1231019343876751 0.12310193438767514 0.837890625 0.85 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 AP1_control HSC_identity;log_library 8 4 0.016739774733709713 0.0456183891799146 -0.07267226805892289 0.10615181752634233 0.75 127 32 1.0 -0.017898282644803035 -0.017898282644803063 -0.01789828264480303 0.8067036290322581 0.85 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.047998254289625585 0.03308930521104478 -0.016856783924022185 0.11285329250327336 0.0625 127 32 1.0 -0.13543470281436593 -0.13543470281436598 -0.1354347028143659 0.22916666666666666 0.85 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 HSC_retention HSC_identity;log_library 8 4 0.26237283877742207 0.04776079208340943 0.1687616862939396 0.3559839912609045 0.0078125 127 23 0.71875 -0.017525861600573983 -0.017525861600573997 -0.01752586160057397 0.04296875 0.85 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.033077420606072785 0.026852210316235373 -0.08570775282589412 0.019552911613748544 0.1953125 127 23 0.71875 0.10832503669450172 0.1083250366945017 0.10832503669450173 0.5859375 0.85 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.08334030450785536 0.07721749967170484 -0.06800599484868612 0.23468660386439683 0.328125 127 23 0.71875 0.267762377664109 0.26776237766410893 0.267762377664109 0.5699013157894737 0.85 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.1859850139885526 0.05961696537448615 0.06913576185455975 0.3028342661225455 0.015625 127 23 0.71875 0.06161597499443527 0.06161597499443525 0.06161597499443529 0.30078125 0.85 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 AP1_control HSC_identity;log_library 8 4 0.061244773584269545 0.05263490240947309 -0.04191963513829771 0.1644091823068368 0.2109375 127 23 0.71875 -0.002233245523544785 -0.0022332455235448134 -0.002233245523544781 0.4296875 0.85 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08853409734685458 0.08533410148396194 -0.0787207415617108 0.25578893625542 0.2578125 127 23 0.71875 0.15695632719431568 0.15695632719431565 0.15695632719431568 0.5859375 0.85 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 HSC_retention HSC_identity;log_library 8 4 0.06076355270092972 0.02775928152000589 0.006355360921718178 0.11517174448014127 0.1953125 127 32 1.0 0.2516802445719431 0.251680244571943 0.2516802445719431 0.322265625 0.85 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.029930118126199237 0.010898942677067064 -0.05129204577325068 -0.00856819047914779 0.015625 127 32 1.0 -0.09423060754197264 -0.09423060754197264 -0.09423060754197259 0.171875 0.85 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03580585968593316 0.027320140415593625 -0.017741615528630343 0.08935333490049666 0.359375 127 32 1.0 0.02650758329230638 0.026507583292306375 0.026507583292306413 0.59296875 0.85 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.05470148252457918 0.03874615021356077 -0.021240971893999927 0.1306439369431583 0.203125 127 32 1.0 0.17449517544033102 0.174495175440331 0.17449517544033102 0.3723958333333333 0.85 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 AP1_control HSC_identity;log_library 8 4 0.06762426639027258 0.01808052987403491 0.03218642783716416 0.103062104943381 0.015625 127 32 1.0 0.12120386969672403 0.121203869696724 0.12120386969672407 0.1546875 0.85 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08344216240404387 0.036909887602691135 0.011098782702769247 0.15578554210531848 0.0390625 127 32 1.0 0.01824012573183815 0.018240125731838124 0.018240125731838176 0.1611328125 0.85 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 HSC_retention HSC_identity;log_library 8 4 0.004182427172188537 0.022299377566906076 -0.03952435285894737 0.047889207203324444 0.875 127 32 1.0 0.07493240069339538 0.07493240069339537 0.0749324006933954 0.90234375 0.85 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.003381868789688836 0.02332385619295181 -0.04233288934849671 0.049096626927874386 0.84375 127 32 1.0 0.12567554827538835 0.1256755482753883 0.12567554827538838 0.9564012096774194 0.85 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.005140369551406907 0.023266648120255196 -0.040462260764293274 0.050742999867107084 0.84375 127 32 1.0 0.07313034384278978 0.07313034384278976 0.07313034384278978 0.878173828125 0.85 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.0019380759403829586 0.02795836852047571 -0.056736478240515344 0.05286032635974943 0.96875 127 32 1.0 -0.023273716543762518 -0.02327371654376252 -0.023273716543762507 0.96875 0.85 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 AP1_control HSC_identity;log_library 8 4 -0.035585594824623513 0.025381866124854147 -0.08533405242933764 0.014162862780090615 0.125 127 32 1.0 0.049079538209811174 0.04907953820981117 0.04907953820981119 0.29464285714285715 0.85 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.004655446792405668 0.038594769623871754 -0.07099030167038298 0.0803011952551943 0.8828125 127 32 1.0 -0.03070781178005006 -0.03070781178005007 -0.030707811780050047 0.9397681451612904 0.85 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 HSC_retention HSC_identity;log_library 8 4 0.029778094620635034 0.03499217679943943 -0.038806571906266255 0.09836276114753632 0.3984375 127 29 0.90625 0.0633274565252049 0.06332745652520487 0.0633274565252049 0.5259375 0.85 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.023354934839317668 0.030628186718505663 -0.08338618080758876 0.036676311128953434 0.46875 127 29 0.90625 0.0742488644850514 0.07424886448505139 0.07424886448505143 0.8348214285714286 0.85 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.005952827537563268 0.04064823305118647 -0.07371770924276222 0.08562336431788875 0.90625 127 29 0.90625 0.1824143597319602 0.18241435973196019 0.18241435973196024 0.90625 0.85 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.052004596088561506 0.04310167894590131 -0.03247469464540506 0.13648388682252807 0.21875 127 29 0.90625 0.010835242891380882 0.010835242891380853 0.010835242891380896 0.37993421052631576 0.85 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 AP1_control HSC_identity;log_library 8 4 -0.05734161695004164 0.04286121673095459 -0.14134960174271263 0.02666636784262935 0.15625 127 29 0.90625 -0.12537301687125296 -0.125373016871253 -0.12537301687125293 0.34375 0.85 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.10600380313507418 0.05929259306778765 -0.01020967927778961 0.22221728554793796 0.1171875 127 29 0.90625 0.24265667167727425 0.24265667167727423 0.24265667167727428 0.322265625 0.85 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 HSC_retention HSC_identity;log_library 8 4 0.14647829153554742 0.030560933868652124 0.08657886115298927 0.20637772191810558 0.0078125 127 32 1.0 0.2754885757428729 0.2754885757428729 0.27548857574287294 0.04296875 0.85 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.002345441449160318 0.028736648180919474 -0.05866927188376248 0.05397838898544185 0.8984375 127 32 1.0 -0.13225608677903997 -0.13225608677904002 -0.13225608677903997 0.9564012096774194 0.85 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07183034275363864 0.03501628573599545 0.0031984227110875563 0.14046226279618973 0.125 127 32 1.0 0.17671638631095657 0.17671638631095654 0.1767163863109566 0.4125 0.85 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0588734912793208 0.028220641712706506 0.003561033522416053 0.11418594903622556 0.078125 127 32 1.0 0.00033358229454256283 0.00033358229454255177 0.0003335822945425846 0.3046875 0.85 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 AP1_control HSC_identity;log_library 8 4 0.13986579521512554 0.04040301443567216 0.06067588692120811 0.21905570350904296 0.078125 127 32 1.0 0.4841639889284753 0.4841639889284752 0.48416398892847534 0.234375 0.85 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.019384167849921516 0.033592048471132216 -0.04645624715349762 0.08522458285334066 0.359375 127 32 1.0 -0.2950192537851099 -0.29501925378511 -0.29501925378510985 0.5859375 0.85 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 HSC_retention HSC_identity;log_library 8 4 0.2747583626064844 0.0462021157616098 0.1842022157137292 0.3653145094992396 0.015625 127 32 1.0 0.15596828248806732 0.15596828248806732 0.15596828248806735 0.064453125 0.85 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.05313117271014735 0.019286027570274908 0.015330558672408526 0.09093178674788617 0.015625 127 32 1.0 -0.02850592010163234 -0.028505920101632345 -0.02850592010163232 0.171875 0.85 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.047509754234434494 0.04121317557715018 -0.03326806989677986 0.12828757836564886 0.15625 127 32 1.0 -0.03318926372234595 -0.03318926372234598 -0.033189263722345944 0.46875 0.85 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.03368065227716856 0.060812512498353184 -0.08551187221960369 0.1528731767739408 0.609375 127 32 1.0 -0.02568018599655091 -0.02568018599655091 -0.02568018599655089 0.837890625 0.85 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 AP1_control HSC_identity;log_library 8 4 0.1472330812113302 0.04708039308158635 0.054955510771420954 0.23951065165123941 0.0234375 127 32 1.0 0.1555900500714032 0.1555900500714032 0.15559005007140322 0.1546875 0.85 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.11564968669518562 0.04014584233539229 0.03696383571781672 0.19433553767255451 0.0234375 127 32 1.0 0.24218169105983542 0.2421816910598354 0.24218169105983545 0.1611328125 0.85 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 HSC_retention HSC_identity;log_library 8 4 0.05890107945533624 0.03561142214173982 -0.010897307942473795 0.1286994668531463 0.0546875 127 32 1.0 -0.05520143021418519 -0.055201430214185214 -0.05520143021418517 0.1388221153846154 0.9 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.030640755016509747 0.05106017481262726 -0.06943718761623968 0.13071869764925917 0.515625 127 32 1.0 0.056112808031404414 0.05611280803140439 0.056112808031404435 0.8406929347826086 0.9 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07462233084624967 0.036477264410545204 0.003126892601581069 0.14611776909091828 0.09375 127 32 1.0 -0.04653963502181695 -0.04653963502181696 -0.04653963502181693 0.309375 0.9 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.002976383949710451 0.04327865406754196 -0.08184977802267179 0.08780254592209269 0.953125 127 32 1.0 -0.2241192336107432 -0.22411923361074326 -0.22411923361074318 0.98291015625 0.9 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 AP1_control HSC_identity;log_library 8 4 0.00899022279975421 0.03667104601388253 -0.06288502738745555 0.08086547298696398 0.84375 127 32 1.0 0.1331705442486905 0.1331705442486905 0.13317054424869054 0.928125 0.9 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.031935833426765994 0.03993502715006388 -0.04633681978735922 0.11020848664089121 0.28125 127 32 1.0 -0.09382264616736254 -0.09382264616736256 -0.09382264616736254 0.580078125 0.9 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 HSC_retention HSC_identity;log_library 8 4 0.052213127584664606 0.019569515580740243 0.01385687704641373 0.09056937812291549 0.0234375 127 32 1.0 0.24327488543953749 0.24327488543953743 0.24327488543953757 0.07734375 0.9 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.0027785534375168648 0.016957861324173068 -0.03045885475786235 0.03601596163289608 0.8359375 127 32 1.0 -0.08040604317151455 -0.08040604317151456 -0.08040604317151452 0.9601293103448276 0.9 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.025061032837881376 0.03733306178580127 -0.04811176826228912 0.09823383393805186 0.546875 127 32 1.0 -0.1402082121460079 -0.14020821214600793 -0.1402082121460079 0.7626953125 0.9 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.00014161787449129787 0.019855733463390913 -0.03877561971375489 0.039058855462737484 0.9921875 127 32 1.0 -0.09936647896327314 -0.09936647896327315 -0.09936647896327311 0.9921875 0.9 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 AP1_control HSC_identity;log_library 8 4 0.024015311860229687 0.020544149960075718 -0.01625122206151872 0.0642818457819781 0.2421875 127 32 1.0 -0.07783917775840343 -0.07783917775840343 -0.07783917775840342 0.49951171875 0.9 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.03124299296522182 0.02596313112380642 -0.019644744037438763 0.0821307299678824 0.203125 127 32 1.0 -0.20245197213629101 -0.20245197213629107 -0.20245197213629101 0.49720982142857145 0.9 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 HSC_retention HSC_identity;log_library 8 4 0.0255063919030416 0.03304084876278349 -0.03925367167201403 0.09026645547809724 0.3671875 127 32 1.0 0.029774533871309673 0.029774533871309666 0.029774533871309683 0.47596153846153844 0.9 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.030595392741154456 0.02484467577159589 -0.01810017177117349 0.0792909572534824 0.046875 127 32 1.0 -0.20614846518837726 -0.20614846518837732 -0.20614846518837723 0.38671875 0.9 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.0038565076984331094 0.026110016101091354 -0.04731912385970594 0.05503213925657217 0.875 127 32 1.0 -0.29429692360148046 -0.2942969236014805 -0.29429692360148035 0.9314516129032258 0.9 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.014839092877981103 0.0303842284192011 -0.044713994823653055 0.07439218057961526 0.5546875 127 32 1.0 0.035733562511976465 0.03573356251197645 0.03573356251197648 0.78375 0.9 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 AP1_control HSC_identity;log_library 8 4 -0.021872461200358143 0.047156239636739886 -0.11429869088836832 0.07055376848765203 0.5078125 127 32 1.0 -0.28159213437006203 -0.28159213437006203 -0.281592134370062 0.7286005434782609 0.9 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.06376205977527862 0.030504307101776516 0.0039736178557966476 0.12355050169476059 0.1875 127 32 1.0 0.2044461144124028 0.2044461144124028 0.20444611441240285 0.49720982142857145 0.9 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 HSC_retention HSC_identity;log_library 8 4 0.021228125228244375 0.02330806124905935 -0.024455674819911954 0.0669119252764007 0.3671875 127 32 1.0 0.0885097286007272 0.08850972860072719 0.08850972860072721 0.47596153846153844 0.9 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.004403078003884494 0.020906645816903487 -0.04538010380501533 0.03657394779724634 0.84375 127 32 1.0 0.014539082874352564 0.014539082874352564 0.014539082874352594 0.9601293103448276 0.9 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07181925240003369 0.02400537042504299 0.024768726366949427 0.11886977843311794 0.015625 127 32 1.0 -0.06950541049717364 -0.06950541049717364 -0.06950541049717361 0.2578125 0.9 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.02230700502931398 0.02020299303474616 -0.06190487137741645 0.017290861318788493 0.359375 127 32 1.0 0.20244849516750002 0.20244849516749996 0.20244849516750005 0.6875 0.9 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 AP1_control HSC_identity;log_library 8 4 0.0863704000901316 0.028745646530777144 0.030028932889808395 0.1427118672904548 0.0078125 127 32 1.0 -0.20762487114368758 -0.2076248711436876 -0.20762487114368758 0.0859375 0.9 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.068748779643963 0.017888922193431918 0.03368649214483645 0.10381106714308956 0.0078125 127 32 1.0 0.0247631098077852 0.02476310980778518 0.0247631098077852 0.12890625 0.9 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 HSC_retention HSC_identity;log_library 8 4 0.2645805959951524 0.05450512474523852 0.1577505514944849 0.37141064049581984 0.0078125 127 27 0.84375 0.09684279808868701 0.09684279808868691 0.09684279808868702 0.036830357142857144 0.9 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.061167067453100424 0.03485475064191209 -0.007148243805047277 0.12948237871124813 0.09375 127 27 0.84375 0.12199242153453166 0.12199242153453164 0.12199242153453169 0.4419642857142857 0.9 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.1627918655324506 0.0777704471988878 0.010361789022630491 0.3152219420422707 0.078125 127 27 0.84375 0.06502994713538543 0.06502994713538542 0.06502994713538546 0.309375 0.9 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.1099931149491702 0.08858858293395702 -0.06364050760138555 0.28362673749972594 0.1328125 127 27 0.84375 -0.20477854499169468 -0.20477854499169468 -0.20477854499169462 0.3984375 0.9 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 AP1_control HSC_identity;log_library 8 4 0.15587552303864566 0.052412185070526626 0.05314764030041347 0.25860340577687785 0.03125 127 27 0.84375 0.025702417059866665 0.025702417059866655 0.025702417059866683 0.20625 0.9 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.19488486428787516 0.0693605928045336 0.05893810239098929 0.33083162618476103 0.0078125 127 27 0.84375 0.0009116447341151603 0.0009116447341151394 0.0009116447341151859 0.12890625 0.9 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 HSC_retention HSC_identity;log_library 8 4 0.03999732586281845 0.03515291286540374 -0.028902383353372883 0.10889703507900977 0.4375 127 32 1.0 0.19761815056289525 0.1976181505628952 0.19761815056289525 0.515625 0.9 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.008153034399441204 0.018149357578046255 -0.027419706453529452 0.043725775252411864 0.53125 127 32 1.0 -0.3072255726093859 -0.3072255726093859 -0.30722557260938577 0.8406929347826086 0.9 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04186786120800501 0.032734877073223596 -0.022292497855513238 0.10602822027152325 0.2890625 127 32 1.0 0.09470832326815946 0.09470832326815944 0.09470832326815948 0.5299479166666666 0.9 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.009250203197321744 0.02643935666620531 -0.04257093586844066 0.06107134226308415 0.71875 127 32 1.0 -0.061026644046925003 -0.06102664404692501 -0.06102664404692498 0.8470982142857143 0.9 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 AP1_control HSC_identity;log_library 8 4 0.03366809885536125 0.036204878680950695 -0.037293463359302115 0.10462966107002461 0.40625 127 32 1.0 0.09658133844219285 0.09658133844219285 0.09658133844219287 0.6383928571428571 0.9 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.00616979708165781 0.025915743658134937 -0.04462506048828666 0.05696465465160228 0.765625 127 32 1.0 -0.16944845391110355 -0.16944845391110355 -0.16944845391110352 0.859375 0.9 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 HSC_retention HSC_identity;log_library 8 4 0.12971713552463904 0.02316617853647522 0.08431142559314761 0.17512284545613047 0.0078125 127 32 1.0 -0.03228242365831791 -0.032282423658317926 -0.032282423658317905 0.036830357142857144 0.9 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.005108902402070485 0.027962015967809804 -0.04969664889483673 0.0599144536989777 0.890625 127 32 1.0 -0.1125379905864636 -0.11253799058646363 -0.11253799058646356 0.966796875 0.9 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04996871075530483 0.03090407431219353 -0.010603274896594489 0.11054069640720415 0.1484375 127 32 1.0 0.059649141480478333 0.059649141480478306 0.05964914148047835 0.408203125 0.9 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.07482678912378202 0.031902321834382595 0.012298238328392136 0.1373553399191719 0.0078125 127 32 1.0 -0.015357487040276238 -0.015357487040276284 -0.015357487040276226 0.193359375 0.9 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 AP1_control HSC_identity;log_library 8 4 0.08180840352949821 0.04739468210534882 -0.011085173396985476 0.1747019804559819 0.171875 127 32 1.0 0.029145934916252524 0.029145934916252506 0.029145934916252555 0.49951171875 0.9 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.006642403462397852 0.029744607187532614 -0.051657026625166066 0.06494183354996177 0.78125 127 32 1.0 -0.15296675771235815 -0.15296675771235815 -0.15296675771235813 0.859375 0.9 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 HSC_retention HSC_identity;log_library 8 4 0.02218304087137707 0.02562307379043224 -0.028038183757870122 0.07240426550062426 0.375 127 32 1.0 0.17446442613930607 0.17446442613930607 0.17446442613930607 0.47596153846153844 0.9 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.0006993578170860833 0.019203083708541378 -0.036938686251655015 0.03833740188582718 0.9765625 127 32 1.0 0.15124155623388846 0.15124155623388844 0.1512415562338885 0.9765625 0.9 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.030361715470158087 0.02400750347497236 -0.01669299134078774 0.07741642228110392 0.2109375 127 32 1.0 -0.22450161102120877 -0.22450161102120883 -0.22450161102120872 0.4640625 0.9 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.006954362825067224 0.027076257540751658 -0.046115101954806025 0.06002382760494047 0.8203125 127 32 1.0 0.12443521816824854 0.12443521816824851 0.12443521816824854 0.90234375 0.9 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 AP1_control HSC_identity;log_library 8 4 0.007959677865236318 0.027267064748785094 -0.045483769042382466 0.0614031247728551 0.7578125 127 32 1.0 -0.24688108635507078 -0.2468810863550708 -0.24688108635507075 0.8931361607142857 0.9 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.009118449748824599 0.02509745187679852 -0.05830945542734969 0.04007255592970049 0.734375 127 32 1.0 -0.29403843405663815 -0.29403843405663815 -0.29403843405663804 0.859375 0.9 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 HSC_retention HSC_identity;log_library 8 4 -0.014295540553148219 0.026752543217920983 -0.06673052526027334 0.03813944415397691 0.59375 127 31 0.96875 0.08989785927268847 0.08989785927268844 0.08989785927268848 0.653125 0.9 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.021480235415395392 0.02696432562351134 -0.07433031363747762 0.03136984280668684 0.4765625 127 31 0.96875 -0.11566632668776308 -0.1156663266877631 -0.11566632668776303 0.8406929347826086 0.9 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.026062337389724233 0.020950939634469513 -0.015001504293836013 0.06712617907328448 0.328125 127 31 0.96875 -0.0454420554159561 -0.045442055415956126 -0.04544205541595608 0.5699013157894737 0.9 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.014103884816252821 0.030644851465629164 -0.07416779368888599 0.04596002405638034 0.59375 127 31 0.96875 -0.10272728081020309 -0.10272728081020309 -0.10272728081020302 0.78375 0.9 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 AP1_control HSC_identity;log_library 8 4 -0.025236502271538428 0.03434425727931471 -0.09255124653899525 0.042078241995918406 0.6640625 127 31 0.96875 0.12116074647509928 0.12116074647509928 0.12116074647509933 0.8527644230769231 0.9 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.012812785241981199 0.032022605142035095 -0.07557709132037 0.04995152083640759 0.6796875 127 31 0.96875 0.14236080083357391 0.14236080083357386 0.14236080083357394 0.859375 0.9 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 HSC_retention HSC_identity;log_library 8 4 0.09407099165326795 0.06802276536823651 -0.03925362846847562 0.2273956117750115 0.109375 127 32 1.0 0.057045136261572496 0.057045136261572454 0.05704513626157251 0.20052083333333334 0.9 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.02246013333277924 0.03141134556489041 -0.039106103974405976 0.08402637063996445 0.5390625 127 32 1.0 0.01903080076015159 0.01903080076015157 0.01903080076015159 0.8406929347826086 0.9 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.010449320007228683 0.050777893134236134 -0.10997399055033151 0.08907535053587413 0.8515625 127 32 1.0 0.14347379862872486 0.14347379862872484 0.14347379862872486 0.9314516129032258 0.9 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.024326289793400468 0.05060487765718386 -0.0748592704146799 0.12351185000148084 0.5859375 127 32 1.0 -0.13771355158225954 -0.13771355158225956 -0.13771355158225948 0.78375 0.9 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 AP1_control HSC_identity;log_library 8 4 0.0737526839345015 0.05100970632931834 -0.026226340470962436 0.17373170833996543 0.1875 127 32 1.0 0.2814646879200188 0.28146468792001866 0.2814646879200188 0.49951171875 0.9 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.01113779998552938 0.047038403959973066 -0.08105747177601783 0.1033330717470766 0.84375 127 32 1.0 -0.024171391355007826 -0.02417139135500784 -0.024171391355007812 0.8701171875 0.9 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 HSC_retention HSC_identity;log_library 8 4 0.05261269537677379 0.029584484424072147 -0.005372894094407617 0.1105982848479552 0.2265625 127 32 1.0 0.018284740233293177 0.01828474023329315 0.018284740233293205 0.3560267857142857 0.9 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.012909602053439962 0.01818474550268269 -0.04855170323869803 0.02273249913181811 0.40625 127 32 1.0 -0.0453280391465105 -0.04532803914651051 -0.0453280391465105 0.8406929347826086 0.9 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.019400126655645538 0.026042410020354036 -0.03164299698424837 0.07044325029553945 0.578125 127 32 1.0 -0.07620753611007038 -0.0762075361100704 -0.07620753611007036 0.763125 0.9 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.037639800085428186 0.022604559410903884 -0.006665136359943424 0.0819447365307998 0.2734375 127 32 1.0 0.16873026262965543 0.16873026262965538 0.16873026262965546 0.56396484375 0.9 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 AP1_control HSC_identity;log_library 8 4 -0.004433529363715944 0.02491169079367023 -0.0532604433193096 0.04439338459187771 0.875 127 32 1.0 0.1297420591397895 0.12974205913978948 0.12974205913978953 0.9314516129032258 0.9 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.013398094615351607 0.025172868528961032 -0.03594072770141201 0.06273691693211522 0.5078125 127 32 1.0 -0.14554271893543605 -0.1455427189354361 -0.14554271893543605 0.708984375 0.9 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 HSC_retention HSC_identity;log_library 8 4 0.01234032685190905 0.025083593703325725 -0.03682351680660937 0.06150417051042747 0.6171875 127 32 1.0 0.011176941491978903 0.011176941491978891 0.01117694149197892 0.6570060483870968 0.9 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.025100264724724843 0.0339034863462428 -0.09155109796336074 0.04135056851391104 0.3984375 127 32 1.0 -0.30411849318042145 -0.30411849318042145 -0.3041184931804213 0.8406929347826086 0.9 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.00568601913976376 0.06215319861991185 -0.11613425015526346 0.12750628843479098 0.90625 127 32 1.0 -0.11351560899839727 -0.11351560899839731 -0.11351560899839727 0.9345703125 0.9 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.019323229684692442 0.05015892286894283 -0.0789882591384355 0.11763471850782038 0.6328125 127 32 1.0 -0.10748946689971431 -0.10748946689971434 -0.10748946689971427 0.8031850961538461 0.9 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 AP1_control HSC_identity;log_library 8 4 0.015159331748650157 0.0620215029653214 -0.10640281406337979 0.1367214775606801 0.84375 127 32 1.0 0.031756965791358 0.03175696579135799 0.03175696579135802 0.928125 0.9 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.058437371642790774 0.05494929309713909 -0.1661379861131834 0.04926324282760184 0.3203125 127 32 1.0 -0.06501547336761469 -0.06501547336761469 -0.06501547336761468 0.580078125 0.9 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 HSC_retention HSC_identity;log_library 8 4 0.13664265159837893 0.08168355809817958 -0.023457122274053027 0.29674242547081087 0.1484375 127 32 1.0 0.018170268351886894 0.018170268351886877 0.0181702683518869 0.2578125 0.9 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.09065281313284151 0.04541595759538123 0.0016375362458943 0.17966809001978873 0.0390625 127 32 1.0 -0.05035803088916444 -0.05035803088916446 -0.05035803088916443 0.38671875 0.9 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.10815817226567892 0.05116526013173792 -0.20844208212388526 -0.00787426240747259 0.09375 127 32 1.0 0.08340887487013489 0.08340887487013487 0.0834088748701349 0.309375 0.9 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0988434648165112 0.07837066270922718 -0.05476303409357407 0.25244996372659645 0.1875 127 32 1.0 -0.08829996692536138 -0.08829996692536142 -0.08829996692536138 0.4419642857142857 0.9 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 AP1_control HSC_identity;log_library 8 4 0.10578334499923586 0.055673301118970495 -0.0033363251939463046 0.21490301519241803 0.1015625 127 32 1.0 -0.027856140626926307 -0.02785614062692633 -0.027856140626926294 0.4189453125 0.9 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.10441274551627386 0.08114053379143853 -0.054622700714945654 0.26344819174749334 0.34375 127 32 1.0 -0.04670274602541425 -0.04670274602541431 -0.04670274602541425 0.580078125 0.9 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 HSC_retention HSC_identity;log_library 8 4 -0.010052419877046196 0.014519827371521243 -0.03851128152522783 0.01840644177113544 0.421875 127 32 1.0 -0.205191464306162 -0.20519146430616206 -0.20519146430616197 0.515625 0.9 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.011112403795313227 0.021768934866175576 -0.031554708542390904 0.053779516133017354 0.5234375 127 32 1.0 -0.14144196531882616 -0.14144196531882622 -0.14144196531882616 0.8406929347826086 0.9 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04549398180998205 0.01826735377948168 0.009689968402197956 0.08129799521776615 0.0234375 127 32 1.0 -0.02198625332530103 -0.021986253325301058 -0.02198625332530102 0.2578125 0.9 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.04000326571282084 0.018816827339839824 -0.07688424729890689 -0.0031222841267347853 0.03125 127 32 1.0 -0.1862114236030661 -0.18621142360306614 -0.18621142360306606 0.20625 0.9 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 AP1_control HSC_identity;log_library 8 4 -0.02231069263637419 0.04098004241888626 -0.10263157577739127 0.05801019050464288 0.671875 127 32 1.0 0.22753564090958336 0.2275356409095833 0.22753564090958342 0.8527644230769231 0.9 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.03994667317806319 0.02805229293553951 -0.01503582097559425 0.09492916733172063 0.03125 127 32 1.0 -0.13896161994541392 -0.13896161994541392 -0.13896161994541387 0.171875 0.9 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 HSC_retention HSC_identity;log_library 8 4 0.0023190735245611793 0.019692912920637472 -0.03627903579988827 0.04091718284901062 0.9296875 127 28 0.875 0.029757503750501256 0.029757503750501242 0.029757503750501266 0.9296875 0.9 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.003818516514841862 0.03249985892426801 -0.05988120697672344 0.06751824000640716 0.9140625 127 28 0.875 -0.08119721502105348 -0.08119721502105348 -0.08119721502105344 0.966796875 0.9 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.035622793100520515 0.042804723328627885 -0.11952005082463116 0.048274464623590134 0.5546875 127 28 0.875 -0.04252754878726589 -0.04252754878726591 -0.042527548787265876 0.7626953125 0.9 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.018130286764980047 0.024947076745693155 -0.03076598365657854 0.06702655718653863 0.4375 127 28 0.875 -0.06730378583106188 -0.06730378583106193 -0.06730378583106188 0.7598684210526315 0.9 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 AP1_control HSC_identity;log_library 8 4 0.005189864354663673 0.05473057110804524 -0.10208205501710499 0.11246178372643234 0.953125 127 28 0.875 0.23441517759487274 0.23441517759487263 0.23441517759487274 0.98291015625 0.9 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.07474166102609096 0.062071536908422154 -0.046918551314416454 0.19640187336659837 0.2421875 127 28 0.875 0.04684001436071985 0.046840014360719835 0.04684001436071986 0.5328125 0.9 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 HSC_retention HSC_identity;log_library 8 4 0.016019988736186902 0.01539951805586337 -0.014163066653305304 0.046203044125679105 0.2578125 127 30 0.9375 -0.17034092781296278 -0.1703409278129628 -0.17034092781296276 0.38671875 0.9 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.00962922724545931 0.019476174337499326 -0.04780252894695799 0.02854407445603937 0.7109375 127 30 0.9375 0.2554494191625443 0.25544941916254427 0.2554494191625443 0.9071180555555556 0.9 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03486922479042013 0.0326854828120834 -0.02919432152126334 0.0989327711021036 0.28125 127 30 0.9375 -0.07967218492797938 -0.07967218492797938 -0.07967218492797937 0.5299479166666666 0.9 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.0025596344213327923 0.01980252257532488 -0.04137257866896956 0.036253309826303974 0.8671875 127 30 0.9375 -0.13387954274375044 -0.13387954274375044 -0.13387954274375038 0.9231350806451613 0.9 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 AP1_control HSC_identity;log_library 8 4 0.021385373153417497 0.03222028302765173 -0.04176638158077989 0.08453712788761489 0.5703125 127 30 0.9375 0.08030147313970132 0.0803014731397013 0.08030147313970132 0.7841796875 0.9 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.05162382613285891 0.025491904525152997 0.0016596932635590395 0.10158795900215878 0.0625 127 30 0.9375 0.017703393777492204 0.017703393777492187 0.017703393777492204 0.2578125 0.9 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 HSC_retention HSC_identity;log_library 8 4 0.08527526540753119 0.032884931842632324 0.020820798995971834 0.14972973181909055 0.0390625 127 28 0.875 0.15095741299401755 0.15095741299401752 0.15095741299401758 0.1171875 0.9 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.050695654010094654 0.04184188700503572 -0.13270575253996467 0.03131444451977536 0.1796875 127 28 0.875 0.11421252057005657 0.11421252057005656 0.11421252057005657 0.59296875 0.9 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.14675904654339025 0.05119018355340372 0.04642628677871896 0.24709180630806155 0.078125 127 28 0.875 0.06698621069177772 0.0669862106917777 0.06698621069177774 0.309375 0.9 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.010779103916087425 0.039339993661221866 -0.06632728365990744 0.08788549149208229 0.7890625 127 28 0.875 0.18114360519248868 0.18114360519248865 0.1811436051924887 0.8978987068965517 0.9 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 AP1_control HSC_identity;log_library 8 4 0.058764872300598965 0.06412100510124 -0.06691229769783144 0.18444204229902936 0.2421875 127 28 0.875 0.18390869627611078 0.18390869627611073 0.1839086962761108 0.49951171875 0.9 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.04492349698963733 0.05631478129755827 -0.06545347435357687 0.15530046833285155 0.3984375 127 28 0.875 -0.06685837558332568 -0.0668583755833257 -0.06685837558332566 0.6261160714285714 0.9 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 HSC_retention HSC_identity;log_library 8 4 0.009917924261474293 0.019198426617078202 -0.02771099190799898 0.04754684043094757 0.53125 127 32 1.0 0.01570788942384098 0.015707889423840958 0.015707889423840982 0.6045258620689655 0.9 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.008188581114442085 0.025788837042158234 -0.04235753948818806 0.05873470171707222 0.7421875 127 32 1.0 -0.05582858408753578 -0.05582858408753579 -0.05582858408753576 0.9071180555555556 0.9 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.030688730158887696 0.0315092401336503 -0.03106938050306689 0.09244684082084229 0.2109375 127 32 1.0 -0.0995891780149854 -0.09958917801498543 -0.09958917801498539 0.4640625 0.9 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.012096227888191381 0.026043336859452336 -0.06314116813271796 0.038948712356335194 0.671875 127 32 1.0 0.07081131105129998 0.07081131105129997 0.07081131105130001 0.8211805555555556 0.9 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 AP1_control HSC_identity;log_library 8 4 0.045404150887121075 0.0294726887330889 -0.012362319029733164 0.10317062080397532 0.203125 127 32 1.0 0.04988246134583721 0.049882461345837195 0.04988246134583722 0.49951171875 0.9 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.02471722798854771 0.02378283987005784 -0.021897138156765653 0.07133159413386107 0.4609375 127 32 1.0 0.1030838313437641 0.10308383134376407 0.1030838313437641 0.69140625 0.9 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 HSC_retention HSC_identity;log_library 8 4 0.05227917449714023 0.0330225702691804 -0.012445063230453357 0.11700341222473382 0.078125 127 32 1.0 0.13839135290998805 0.13839135290998805 0.1383913529099881 0.18415178571428573 0.9 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.014018206290332512 0.019032519606076763 -0.051321944718242966 0.02328553213757794 0.4453125 127 32 1.0 0.03668778517589933 0.03668778517589932 0.03668778517589937 0.8406929347826086 0.9 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.04999862200088738 0.030781887137822875 -0.010333876789245452 0.11033112079102021 0.0859375 127 32 1.0 -0.032303166516465864 -0.03230316651646587 -0.03230316651646585 0.309375 0.9 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.02220165745637019 0.028222566473125172 -0.03311457283095515 0.07751788774369553 0.4765625 127 32 1.0 -0.12812198700309074 -0.1281219870030908 -0.12812198700309074 0.78375 0.9 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 AP1_control HSC_identity;log_library 8 4 0.061601316091371545 0.03332749458685443 -0.0037205732988631404 0.12692320548160624 0.2265625 127 32 1.0 0.017736406973762303 0.017736406973762286 0.01773640697376233 0.49951171875 0.9 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.0352748888255191 0.025128881490634403 -0.013977718896124328 0.08452749654716253 0.140625 127 32 1.0 -0.024199711431415638 -0.024199711431415687 -0.02419971143141563 0.421875 0.9 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 HSC_retention HSC_identity;log_library 8 4 0.20857392140758932 0.05523618663433482 0.10031099560429307 0.31683684721088556 0.0078125 127 32 1.0 0.08585848413681957 0.08585848413681955 0.0858584841368196 0.036830357142857144 0.9 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.010529228394457486 0.04315077861496605 -0.07404629769087598 0.09510475447979094 0.734375 127 32 1.0 0.058716715993704066 0.05871671599370405 0.05871671599370408 0.9071180555555556 0.9 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.00916865811737358 0.0572552506757411 -0.10305163320707898 0.12138894944182614 0.859375 127 32 1.0 -0.011807624449517586 -0.011807624449517592 -0.01180762444951757 0.9314516129032258 0.9 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.07391656958083996 0.05189428119723662 -0.027796221565743823 0.17562936072742374 0.125 127 32 1.0 0.10102763071359354 0.10102763071359351 0.10102763071359354 0.3984375 0.9 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 AP1_control HSC_identity;log_library 8 4 0.09571900089277148 0.048845714737577026 -1.8599992879494986e-05 0.19145660177842244 0.2265625 127 32 1.0 0.09279974948781122 0.09279974948781118 0.09279974948781124 0.49951171875 0.9 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.017916849262298612 0.07544265360441448 -0.12995075180235377 0.165784450326951 0.734375 127 32 1.0 -0.25033680371837386 -0.2503368037183739 -0.2503368037183738 0.859375 0.9 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 HSC_retention HSC_identity;log_library 8 4 0.10685615201128329 0.044836930852282464 0.018975767540809665 0.19473653648175693 0.1015625 127 31 0.96875 0.13509986131016913 0.13509986131016913 0.13509986131016913 0.20052083333333334 0.9 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.04719483517322042 0.03786817624949598 -0.027026790275791697 0.12141646062223255 0.265625 127 31 0.96875 -0.0721925292420094 -0.0721925292420094 -0.07219252924200938 0.796875 0.9 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.001904386514204109 0.055532630486549196 -0.10693956923943232 0.11074834226784053 0.9453125 127 31 0.96875 -0.04593654478014189 -0.04593654478014191 -0.04593654478014187 0.9453125 0.9 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.09867095906542696 0.06441295507076403 -0.02757843287327054 0.22492035100412444 0.1640625 127 31 0.96875 0.08115780642763798 0.08115780642763797 0.08115780642763801 0.4419642857142857 0.9 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 AP1_control HSC_identity;log_library 8 4 0.057539496864272184 0.06903440929155413 -0.07776794534717393 0.1928469390757183 0.390625 127 31 0.96875 -0.10664519443268608 -0.1066451944326861 -0.10664519443268602 0.6383928571428571 0.9 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.049408142168262816 0.0477088409381318 -0.04410118607047551 0.14291747040700115 0.3515625 127 31 0.96875 -0.002458467634290003 -0.002458467634290003 -0.0024584676342899884 0.580078125 0.9 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 HSC_retention HSC_identity;log_library 8 4 0.13889226993851211 0.03780302838658551 0.06479833430080452 0.21298620557621972 0.0078125 127 32 1.0 0.12306534885901009 0.12306534885901005 0.12306534885901015 0.036830357142857144 0.9 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.009550676295949065 0.020947156765803058 -0.05060710355692306 0.03150575096502493 0.5859375 127 32 1.0 -0.13866590233553752 -0.13866590233553755 -0.1386659023355375 0.8406929347826086 0.9 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.11380431048224533 0.02865810509138291 0.05763442450313483 0.16997419646135584 0.0078125 127 32 1.0 0.05612353997967021 0.056123539979670206 0.05612353997967027 0.2578125 0.9 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.07775338341763574 0.029225550231637937 0.020471304963625384 0.1350354618716461 0.0234375 127 32 1.0 -0.008373890254363045 -0.008373890254363057 -0.008373890254363036 0.193359375 0.9 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 AP1_control HSC_identity;log_library 8 4 0.03082677062742832 0.019172842988086334 -0.006752001629220891 0.06840554288407753 0.078125 127 32 1.0 0.20206895441235587 0.20206895441235587 0.20206895441235587 0.36830357142857145 0.9 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.0561234737160628 0.024974329558370565 0.0071737877816564904 0.10507315965046911 0.015625 127 32 1.0 0.048428768522343305 0.0484287685223433 0.04842876852234332 0.171875 0.9 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 HSC_retention HSC_identity;log_library 8 4 0.08921205021190438 0.0398344414733362 0.011136544924165437 0.16728755549964333 0.0859375 127 32 1.0 0.15905591844550115 0.15905591844550115 0.15905591844550118 0.1890625 0.9 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.00804325915806166 0.023989503382692037 -0.03897616747201473 0.05506268578813805 0.7421875 127 32 1.0 0.1015073383288384 0.10150733832883839 0.10150733832883843 0.9071180555555556 0.9 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.005814998391719086 0.04047961285369095 -0.07352504280151517 0.08515503958495335 0.859375 127 32 1.0 0.04357768231708645 0.043577682317086426 0.04357768231708649 0.9314516129032258 0.9 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.046911249738042914 0.031048967453523937 -0.013944726470864005 0.10776722594694983 0.1328125 127 32 1.0 -0.03185353835691802 -0.03185353835691804 -0.031853538356918 0.3984375 0.9 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 AP1_control HSC_identity;log_library 8 4 0.04284775330818066 0.04089353054384222 -0.037303566557750086 0.1229990731741114 0.3125 127 32 1.0 0.09862138205823726 0.09862138205823724 0.09862138205823727 0.5729166666666666 0.9 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.048749745553795 0.026452989708042024 -0.0030981142739673687 0.10059760538155738 0.1328125 127 32 1.0 -0.028402602144766084 -0.028402602144766104 -0.028402602144766084 0.421875 0.9 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 HSC_retention HSC_identity;log_library 8 4 -0.007081616384128866 0.029712871353323785 -0.06531884423664348 0.05115561146838575 0.8203125 127 32 1.0 -0.010813071116433277 -0.010813071116433315 -0.010813071116433277 0.845947265625 0.9 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.04670119167475395 0.02007607086620653 0.007352092776989151 0.08605029057251876 0.0625 127 32 1.0 0.06410818414671017 0.06410818414671014 0.06410818414671018 0.4125 0.9 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.05370272548211465 0.034588512204473426 -0.014090758438653261 0.12149620940288255 0.1640625 127 32 1.0 -0.042385522751944106 -0.04238552275194415 -0.042385522751944106 0.41646634615384615 0.9 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 -0.07528909282061107 0.03876398973841063 -0.1512665127078959 0.0006883270666737662 0.0546875 127 32 1.0 -0.0014100615616928565 -0.0014100615616928728 -0.0014100615616928398 0.30078125 0.9 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 AP1_control HSC_identity;log_library 8 4 0.06455251310420852 0.04492189708939388 -0.023494405191003473 0.1525994313994205 0.2578125 127 32 1.0 0.2670361943061338 0.2670361943061338 0.2670361943061338 0.5004595588235294 0.9 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.006441409525695899 0.03749150068995437 -0.06704193182661466 0.07992475087800646 0.8125 127 32 1.0 0.026955897551989908 0.026955897551989894 0.02695589755198994 0.8649193548387096 0.9 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 HSC_retention HSC_identity;log_library 8 4 0.05684409950151033 0.025651224861546557 0.006567698772879077 0.10712050023014158 0.0234375 127 32 1.0 -0.08702342782848987 -0.08702342782848989 -0.08702342782848985 0.07734375 0.9 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.0356179014865346 0.019651627686962745 -0.0028992887799123845 0.07413509175298158 0.03125 127 32 1.0 -0.04961124989517849 -0.04961124989517852 -0.04961124989517847 0.38671875 0.9 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.006620771606653802 0.030580737368313047 -0.06655901684854737 0.05331747363523977 0.8359375 127 32 1.0 0.222842622712775 0.22284262271277494 0.222842622712775 0.9314516129032258 0.9 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.02635980562946259 0.03412292224862034 -0.040521121977833266 0.09324073323675845 0.5234375 127 32 1.0 -0.008618912272155128 -0.008618912272155149 -0.008618912272155107 0.78375 0.9 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 AP1_control HSC_identity;log_library 8 4 0.02523526986091445 0.025997823776166766 -0.025720464740372415 0.07619100446220131 0.1953125 127 32 1.0 -0.24138999504935577 -0.24138999504935582 -0.2413899950493557 0.49951171875 0.9 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.010768389387547157 0.0270775336670979 -0.06384035537505904 0.042303576599964726 0.609375 127 32 1.0 0.004832249745234888 0.004832249745234883 0.004832249745234909 0.804375 0.9 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 HSC_retention HSC_identity;log_library 8 4 0.1841033734204951 0.047706687190774255 0.09059826652657756 0.27760848031441265 0.0078125 127 32 1.0 0.12391633997598447 0.12391633997598447 0.12391633997598452 0.036830357142857144 0.9 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.05493857579948044 0.026533349667295748 0.0029332104515807714 0.1069439411473801 0.109375 127 32 1.0 0.01950872495383079 0.01950872495383079 0.0195087249538308 0.451171875 0.9 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07831527858336618 0.03359012070243423 0.012478642006595084 0.14415191516013726 0.046875 127 32 1.0 0.03641023914486489 0.036410239144864874 0.03641023914486491 0.309375 0.9 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.047303500576959874 0.03849276641652251 -0.028142321599424237 0.12274932275334399 0.1796875 127 32 1.0 0.0777491809710572 0.07774918097105715 0.07774918097105724 0.4419642857142857 0.9 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 AP1_control HSC_identity;log_library 8 4 0.14254678863795683 0.04376061098713662 0.056775991103169055 0.2283175861727446 0.0078125 127 32 1.0 0.03550518222142226 0.03550518222142224 0.03550518222142226 0.0859375 0.9 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.07537859363444481 0.027993626210906543 0.020511086261067984 0.13024610100782164 0.03125 127 32 1.0 0.22733000976866444 0.2273300097686644 0.2273300097686645 0.171875 0.9 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 HSC_retention HSC_identity;log_library 8 4 0.1342763902014433 0.0605086417601735 0.01567945235150324 0.25287332805138335 0.046875 127 32 1.0 0.25502862202070825 0.25502862202070814 0.2550286220207083 0.12890625 0.9 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.03744114128104913 0.03465426431048119 -0.03048121676749401 0.10536349932959227 0.4609375 127 32 1.0 0.08855276980698538 0.08855276980698537 0.08855276980698541 0.8406929347826086 0.9 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 -0.03936728541508331 0.033423547495210294 -0.10487743850569547 0.026142867675528862 0.234375 127 32 1.0 0.19291234154817988 0.19291234154817985 0.19291234154817996 0.4833984375 0.9 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0827725570845066 0.048788409053555845 -0.012852724660462847 0.17839783882947607 0.0703125 127 32 1.0 0.12310193438767511 0.1231019343876751 0.12310193438767514 0.3314732142857143 0.9 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 AP1_control HSC_identity;log_library 8 4 -0.0007643061948479499 0.044395744153555405 -0.08777996473581655 0.08625135234612065 0.9921875 127 32 1.0 -0.017898282644803035 -0.017898282644803063 -0.01789828264480303 0.9921875 0.9 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.032311780095227796 0.029994446556575256 -0.026477335155659705 0.09110089534611529 0.1328125 127 32 1.0 -0.13543470281436593 -0.13543470281436598 -0.1354347028143659 0.421875 0.9 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 HSC_retention HSC_identity;log_library 8 4 0.2456213338817417 0.06214234141961324 0.12382234469929976 0.36742032306418365 0.0078125 127 23 0.71875 -0.017525861600573983 -0.017525861600573997 -0.01752586160057397 0.036830357142857144 0.9 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.05123982127820877 0.028617538240902116 -0.10733019623037693 0.004850553673959375 0.1484375 127 23 0.71875 0.10832503669450172 0.1083250366945017 0.10832503669450173 0.5442708333333334 0.9 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.059355267972704434 0.08087367917049884 -0.09915714320147329 0.21786767914688215 0.4609375 127 23 0.71875 0.267762377664109 0.26776237766410893 0.267762377664109 0.69140625 0.9 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.19181349273154383 0.0632100992031025 0.06792169829346294 0.3157052871696247 0.015625 127 23 0.71875 0.06161597499443527 0.06161597499443525 0.06161597499443529 0.193359375 0.9 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 AP1_control HSC_identity;log_library 8 4 0.04031163831522694 0.058751096323541266 -0.07484051047891394 0.1554637871093678 0.4375 127 23 0.71875 -0.002233245523544785 -0.0022332455235448134 -0.002233245523544781 0.65625 0.9 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 -0.0554149616630445 0.089544820692235 -0.2309228102198251 0.12009288689373612 0.515625 127 23 0.71875 0.15695632719431568 0.15695632719431565 0.15695632719431568 0.708984375 0.9 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 HSC_retention HSC_identity;log_library 8 4 0.06251622939329225 0.028410936050417557 0.006830794734473844 0.11820166405211066 0.1953125 127 32 1.0 0.2516802445719431 0.251680244571943 0.2516802445719431 0.322265625 0.9 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.02968308186918791 0.011210324358246017 -0.0516553176113501 -0.007710846127025717 0.0078125 127 32 1.0 -0.09423060754197264 -0.09423060754197264 -0.09423060754197259 0.2578125 0.9 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03438824592659151 0.028157545108421087 -0.02080054248591382 0.08957703433909683 0.3984375 127 32 1.0 0.02650758329230638 0.026507583292306375 0.026507583292306413 0.657421875 0.9 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.05596414177717418 0.039648386556683166 -0.021746695873924818 0.13367497942827317 0.2109375 127 32 1.0 0.17449517544033102 0.174495175440331 0.17449517544033102 0.4640625 0.9 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 AP1_control HSC_identity;log_library 8 4 0.06964923970195365 0.01846764085649964 0.033452663623214356 0.10584581578069294 0.0078125 127 32 1.0 0.12120386969672403 0.121203869696724 0.12120386969672407 0.0859375 0.9 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.08810665642828681 0.03768283374203059 0.014248302293906862 0.16196501056266677 0.03125 127 32 1.0 0.01824012573183815 0.018240125731838124 0.018240125731838176 0.171875 0.9 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 HSC_retention HSC_identity;log_library 8 4 0.018656563896591344 0.019981359171755312 -0.020506900080049066 0.057820027873231754 0.3046875 127 32 1.0 0.07493240069339538 0.07493240069339537 0.0749324006933954 0.43716032608695654 0.9 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.011599143769789847 0.021097413671596264 -0.02975178702653883 0.05295007456611853 0.5625 127 32 1.0 0.12567554827538835 0.1256755482753883 0.12567554827538838 0.8406929347826086 0.9 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.004938225194997724 0.021337960253253456 -0.03688417690137905 0.0467606272913745 0.8671875 127 32 1.0 0.07313034384278978 0.07313034384278976 0.07313034384278978 0.9314516129032258 0.9 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.013584497576942954 0.025511585671790973 -0.03641821033976735 0.06358720549365326 0.5078125 127 32 1.0 -0.023273716543762518 -0.02327371654376252 -0.023273716543762507 0.78375 0.9 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 AP1_control HSC_identity;log_library 8 4 -0.023562084268133703 0.02345778615756404 -0.06953934513695922 0.022415176600691814 0.3359375 127 32 1.0 0.049079538209811174 0.04907953820981117 0.04907953820981119 0.5834703947368421 0.9 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.00013861765475660752 0.035408090876010594 -0.06926124046222416 0.06953847577173737 1.0 127 32 1.0 -0.03070781178005006 -0.03070781178005007 -0.030707811780050047 1.0 0.9 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 HSC_retention HSC_identity;log_library 8 4 0.04577956848327311 0.02796097815512299 -0.009023948700767948 0.10058308566731416 0.109375 127 29 0.90625 0.0633274565252049 0.06332745652520487 0.0633274565252049 0.20052083333333334 0.9 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.012166419817954813 0.025498711900401157 -0.037811055506831455 0.06214389514274108 0.5859375 127 29 0.90625 0.0742488644850514 0.07424886448505139 0.07424886448505143 0.8406929347826086 0.9 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.03234507853297663 0.03246112231163321 -0.031278721197824454 0.0959688782637777 0.4609375 127 29 0.90625 0.1824143597319602 0.18241435973196019 0.18241435973196024 0.69140625 0.9 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.029163319170669708 0.03566239438156825 -0.04073497381720406 0.09906161215854348 0.375 127 29 0.90625 0.010835242891380882 0.010835242891380853 0.010835242891380896 0.6875 0.9 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 AP1_control HSC_identity;log_library 8 4 0.010738270743311068 0.03671438841127014 -0.061221930542778406 0.08269847202940055 0.7109375 127 29 0.90625 -0.12537301687125296 -0.125373016871253 -0.12537301687125293 0.8689236111111112 0.9 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.0793611261354574 0.04879502212193942 -0.016277117223543858 0.17499936949445866 0.2109375 127 29 0.90625 0.24265667167727425 0.24265667167727423 0.24265667167727428 0.49720982142857145 0.9 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 HSC_retention HSC_identity;log_library 8 4 0.15185879823273898 0.028447767158178493 0.09610117460270914 0.20761642186276882 0.0078125 127 32 1.0 0.2754885757428729 0.2754885757428729 0.27548857574287294 0.036830357142857144 0.9 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 -0.0014225171348822131 0.02789750599686967 -0.056101628888746764 0.053256594618982335 0.9375 127 32 1.0 -0.13225608677903997 -0.13225608677904002 -0.13225608677903997 0.966796875 0.9 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07373244205956775 0.03445355927515208 0.006203465880269668 0.14126141823886584 0.109375 127 32 1.0 0.17671638631095657 0.17671638631095654 0.1767163863109566 0.328125 0.9 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.06569633178098135 0.02693850795482438 0.01289685618952556 0.11849580737243713 0.0234375 127 32 1.0 0.00033358229454256283 0.00033358229454255177 0.0003335822945425846 0.193359375 0.9 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 AP1_control HSC_identity;log_library 8 4 0.14311633123701567 0.038822569910819865 0.06702409421180873 0.21920856826222263 0.0625 127 32 1.0 0.4841639889284753 0.4841639889284752 0.48416398892847534 0.34375 0.9 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.018829170831588384 0.03325608003753238 -0.046352746041975076 0.08401108770515185 0.3515625 127 32 1.0 -0.2950192537851099 -0.29501925378511 -0.29501925378510985 0.580078125 0.9 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 HSC_retention HSC_identity;log_library 8 4 0.24936606702254618 0.032734166071339214 0.18520710152272132 0.31352503252237107 0.015625 127 32 1.0 0.15596828248806732 0.15596828248806732 0.15596828248806735 0.064453125 0.9 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 Endo_resolver HSC_identity;Endo_identity;log_library 8 4 0.02698300314809994 0.015200570452477332 -0.0028101149387556278 0.05677612123495551 0.078125 127 32 1.0 -0.02850592010163234 -0.028505920101632345 -0.02850592010163232 0.4296875 0.9 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 LAM_resolver HSC_identity;Myeloid_identity;log_library 8 4 0.07724463803509769 0.0382626155055406 0.0022499116442381145 0.15223936442595726 0.078125 127 32 1.0 -0.03318926372234595 -0.03318926372234598 -0.033189263722345944 0.309375 0.9 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 retention_dominance HSC_identity;Endo_identity;Myeloid_identity;log_library 8 4 0.0799398498896754 0.05134919088320197 -0.020704564241400464 0.18058426402075126 0.109375 127 32 1.0 -0.02568018599655091 -0.02568018599655091 -0.02568018599655089 0.3984375 0.9 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 AP1_control HSC_identity;log_library 8 4 0.13800243526233552 0.0368531058732416 0.06577034775078199 0.21023452277388904 0.0234375 127 32 1.0 0.1555900500714032 0.1555900500714032 0.15559005007140322 0.193359375 0.9 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 TGFb_integrator HSC_identity;Myeloid_identity;log_library 8 4 0.09106744904242793 0.04104975850667652 0.010609922369341954 0.1715249757155139 0.0390625 127 32 1.0 0.24218169105983542 0.2421816910598354 0.24218169105983545 0.18415178571428573 0.9 diff --git a/data/UQ_resolver_source_inputs/UQ_Visium_scar_threshold_sensitivity_trends.tsv b/data/UQ_resolver_source_inputs/UQ_Visium_scar_threshold_sensitivity_trends.tsv new file mode 100644 index 0000000..bcd4342 --- /dev/null +++ b/data/UQ_resolver_source_inputs/UQ_Visium_scar_threshold_sensitivity_trends.tsv @@ -0,0 +1,19 @@ +outcome n_patients stage_beta_array_adjusted stage_beta_hc3_se stage_beta_hc3_p stage_beta_within_array_permutation_p spearman_rho spearman_p scar_quantile +AP1_control 32 0.0273821039200299 0.010172492462167696 0.007107197518118905 0.0086 0.5374519880020173 0.001513433619724445 0.8 +Endo_resolver 32 0.0003493847026941714 0.006606573037215371 0.9578240077796315 0.9404 0.10749039760040348 0.5581670965831093 0.8 +HSC_retention 32 0.046626974826214036 0.0133312526121151 0.00046951937661047496 0.0006 0.7219363831830952 3.104245680338804e-06 0.8 +LAM_resolver 32 -0.0032400558013619173 0.01186247872012198 0.7847495937091332 0.6728 0.17676617048472656 0.3331409499116021 0.8 +TGFb_integrator 32 0.009794925562630511 0.008501466233983918 0.2492613129524418 0.2315 0.2354999779301309 0.19445031937046797 0.8 +retention_dominance 32 0.028604276084634707 0.006620979980231307 1.5585388526538762e-05 0.0001 0.7191126424405276 3.536758197347826e-06 0.8 +AP1_control 32 0.027101807448414825 0.008064354956604987 0.000777476722865427 0.0031 0.576607859632287 0.0005518277021802511 0.85 +Endo_resolver 32 0.004867035945837325 0.005278949085285155 0.35654390230876665 0.2524 0.20782731865296922 0.25370715805456917 0.85 +HSC_retention 32 0.039816541436538455 0.011451005195562691 0.000506827250465214 0.0013 0.7718224696351212 2.3112443403278093e-07 0.85 +LAM_resolver 32 -0.005785458185001008 0.010937360088784457 0.5968311564344626 0.4499 0.03143764693391835 0.8643773195012645 0.85 +TGFb_integrator 32 0.0074258750898667635 0.006201728999463666 0.23115540854974026 0.3052 0.29517503228972447 0.10098297894972574 0.85 +retention_dominance 32 0.02361215809568971 0.007332180757293086 0.001280360162487862 0.0003 0.699534706625393 8.386872100168325e-06 0.85 +AP1_control 32 0.020455054538843866 0.005971659971324314 0.0006139968795204316 0.0054 0.517497553421207 0.0024192168825817096 0.9 +Endo_resolver 32 0.0050762248180038876 0.0054402851496929356 0.35077832765320105 0.2149 0.21686328902918528 0.23317957987445637 0.9 +HSC_retention 32 0.03485167441063468 0.009012544581129888 0.00011017418405479359 0.0009 0.7563860202424189 5.510641591746332e-07 0.9 +LAM_resolver 32 -0.003098118653732246 0.009355610000935086 0.7405305072957249 0.6827 0.10485490624067381 0.5679127981510368 0.9 +TGFb_integrator 32 0.008609919802780037 0.006251283922089394 0.16841820729591994 0.2236 0.15041125688742973 0.4112519277136885 0.9 +retention_dominance 32 0.02051781598324532 0.0050050432272280235 4.141719048646799e-05 0.0002 0.725513121457014 2.6255236182148847e-06 0.9 diff --git a/data/UQ_resolver_source_inputs/UQ_Visium_spot_module_scores.parquet b/data/UQ_resolver_source_inputs/UQ_Visium_spot_module_scores.parquet new file mode 100644 index 0000000..fd6f6c0 Binary files /dev/null and b/data/UQ_resolver_source_inputs/UQ_Visium_spot_module_scores.parquet differ diff --git a/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_biopsy_coupling.tsv b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_biopsy_coupling.tsv new file mode 100644 index 0000000..c56e533 --- /dev/null +++ b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_biopsy_coupling.tsv @@ -0,0 +1,232 @@ +biopsy_id patient_cluster array fibrosis_stage stage_numeric stage_group n_spots outcome covariates grid_long grid_cross beta beta_se beta_ci_low beta_ci_high spatial_field_p n_transforms n_blocks grid_occupancy residual_moran permuted_moran_min permuted_moran_max spatial_fdr_within_outcome +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.058188433922067996 0.09453330574963566 -0.1270968453472179 0.24347371319135389 0.484375 127 32 1.0 0.04858786583299755 0.04858786583299754 0.04858786583299756 0.86625 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 feedback_core HSC_identity;log_library 8 4 0.0320330690613843 0.042440111765337726 -0.05114954999867764 0.11521568812144624 0.4375 127 32 1.0 -0.05097807291873993 -0.050978072918739945 -0.0509780729187399 0.6015625 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.04319586851755336 0.05746849938066777 -0.06944239026855546 0.1558341273036622 0.3046875 127 32 1.0 -0.07668026542045002 -0.07668026542045002 -0.07668026542044998 0.5291940789473685 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.025020524794020036 0.07380788190617808 -0.16968397333012908 0.11964292374208901 0.671875 127 32 1.0 0.07176464075251646 0.07176464075251644 0.07176464075251647 0.8211805555555556 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.016618545513265533 0.05342419024639104 -0.0880928673696609 0.12132995839619198 0.8046875 127 32 1.0 -0.030673920560638123 -0.030673920560638137 -0.030673920560638116 0.8046875 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.07990484548424803 0.06518072255523286 -0.047849370724008355 0.20765906169250442 0.1875 127 32 1.0 -0.0882050608568234 -0.08820506085682342 -0.08820506085682338 0.322265625 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late 351 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.0632862999709825 0.07995937796522154 -0.0934340808408517 0.2200066807828167 0.5703125 127 32 1.0 0.05471836378360856 0.054718363783608524 0.05471836378360857 0.6489762931034483 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.1047696709112696 0.07767865048023286 -0.04748048402998681 0.25701982585252603 0.1640625 127 32 1.0 0.03257479402547634 0.032574794025476306 0.03257479402547635 0.703125 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 feedback_core HSC_identity;log_library 8 4 0.0007887651074411469 0.02530617895641274 -0.048811345647127816 0.050388875862010116 0.9921875 127 32 1.0 -0.22152436953641927 -0.22152436953641932 -0.22152436953641924 0.9921875 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 -0.08570175388993907 0.041828425446181594 -0.16768546776445498 -0.0037180400154231547 0.0625 127 32 1.0 -0.11094662755077415 -0.11094662755077418 -0.11094662755077413 0.234375 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.06952498813396646 0.03872298411865391 -0.006372060738595198 0.14542203700652812 0.09375 127 32 1.0 -0.21166503983947513 -0.21166503983947518 -0.21166503983947507 0.34375 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 -0.05375385103693912 0.030686517519702257 -0.11389942537555553 0.006391723301677303 0.109375 127 32 1.0 -0.014468401216343994 -0.014468401216344016 -0.014468401216343987 0.3515625 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.022583359068832902 0.04352341760338655 -0.06272253943380474 0.10788925757147055 0.5625 127 32 1.0 0.11451758210244448 0.11451758210244446 0.11451758210244449 0.6875 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early 709 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.076337210105772 0.049644932259377085 -0.020966857122607083 0.17364127733415108 0.1171875 127 32 1.0 0.01567847772820745 0.015678477728207445 0.01567847772820746 0.47879464285714285 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.0540280122723435 0.1274797196718895 -0.3038882628292469 0.19583223828455992 0.65625 127 32 1.0 -0.07469964261792615 -0.07469964261792617 -0.07469964261792614 0.86625 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 feedback_core HSC_identity;log_library 8 4 0.006637030595778805 0.051492313322659904 -0.0942879035166346 0.10756196470819221 0.90625 127 32 1.0 -0.08000650876014792 -0.08000650876014798 -0.08000650876014789 0.9896673387096774 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.11449309658319955 0.07333907130423103 -0.02925148317309327 0.25823767633949235 0.1171875 127 32 1.0 0.0535496852379978 0.053549685237997774 0.05354968523799781 0.29747596153846156 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.10145902544913786 0.08666044464141308 -0.27131349694630746 0.06839544604803176 0.171875 127 32 1.0 -0.11219634656025007 -0.11219634656025007 -0.11219634656025006 0.494140625 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.07577348223249582 0.053972442145546085 -0.0300125043727745 0.18155946883776614 0.1953125 127 32 1.0 0.08904894072344383 0.0890489407234438 0.08904894072344384 0.3943014705882353 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.1271073851224257 0.07010504699071844 -0.010298506979382449 0.26451327722423384 0.0546875 127 32 1.0 -0.11627528264207698 -0.11627528264207702 -0.11627528264207695 0.14732142857142858 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early 260 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.05133390288992997 0.09353517777002884 -0.13199504553932656 0.23466285131918652 0.5546875 127 32 1.0 -0.13229570520574746 -0.13229570520574746 -0.1322957052057474 0.6489762931034483 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.2903539011874775 0.10887510319830226 0.07695869891880508 0.5037491034561499 0.0703125 127 32 1.0 -0.058536867160022335 -0.05853686716002234 -0.05853686716002231 0.580078125 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 feedback_core HSC_identity;log_library 8 4 0.08725897052811413 0.0416339327762972 0.005656462286571615 0.16886147876965663 0.078125 127 32 1.0 0.04224644636031052 0.0422464463603105 0.042246446360310545 0.1890625 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.008772664977194205 0.04313620933228778 -0.07577430531408985 0.09331963526847825 0.7734375 127 32 1.0 0.04993471578705142 0.0499347157870514 0.04993471578705143 0.797607421875 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.09605579411121404 0.05565161804482008 -0.013021377256633312 0.2051329654790614 0.1640625 127 32 1.0 0.06628484009140924 0.06628484009140921 0.06628484009140924 0.494140625 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 -0.028281767288760445 0.0417650967529912 -0.1101413569246232 0.0535778223471023 0.484375 127 32 1.0 -0.07742535186521643 -0.07742535186521646 -0.07742535186521642 0.6147836538461539 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.16344156242547855 0.056483611653915175 0.05273368358380481 0.2741494412671523 0.0390625 127 32 1.0 -0.05798929592354495 -0.05798929592354498 -0.05798929592354494 0.14322916666666666 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early 423 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.19172332971423908 0.05881201798604527 0.07645177446159036 0.3069948849668878 0.046875 127 32 1.0 -0.06808528196102542 -0.06808528196102545 -0.0680852819610254 0.38671875 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.1339221850836397 0.15501817069676582 -0.4377577996493007 0.1699134294820213 0.4453125 127 27 0.84375 0.01675362721833794 0.01675362721833793 0.016753627218337952 0.86625 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 feedback_core HSC_identity;log_library 8 4 0.16638426356442743 0.05848021838204245 0.05176303553562424 0.2810054915932306 0.0390625 127 27 0.84375 0.26029616719102316 0.26029616719102316 0.26029616719102316 0.14322916666666666 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.2537580542303108 0.08749787245610466 0.08226222421634566 0.4252538842442759 0.0234375 127 27 0.84375 0.038008633474807395 0.03800863347480739 0.0380086334748074 0.12890625 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.29466636968377447 0.12761022345550463 -0.5447824076565635 -0.04455033171098538 0.0234375 127 27 0.84375 0.03925501021880177 0.039255010218801754 0.03925501021880178 0.2578125 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.19514574254500056 0.08956136508506181 0.019605466978279418 0.3706860181117217 0.0078125 127 27 0.84375 0.00529370286463692 0.005293702864636914 0.005293702864636934 0.12890625 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.17265072218269467 0.12498962533679758 -0.07232894347742858 0.4176303878428179 0.21875 127 27 0.84375 0.1637744837001702 0.1637744837001702 0.16377448370017025 0.328125 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late 514 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.0224950203623058 0.1463644028493586 -0.3093692499470486 0.2643792092224371 0.9140625 127 27 0.84375 0.03637007029076351 0.03637007029076347 0.03637007029076352 0.9375 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.0016418254726014434 0.10828745751012281 -0.21060159124723926 0.21388524219244215 0.984375 127 32 1.0 -0.04724463685297749 -0.04724463685297749 -0.04724463685297741 0.984375 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 feedback_core HSC_identity;log_library 8 4 0.0345393529736003 0.03963469904889416 -0.04314465716223225 0.11222336310943284 0.4375 127 32 1.0 -0.16174492012098526 -0.1617449201209853 -0.16174492012098524 0.6015625 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.03831010452010978 0.031225967700743047 -0.02289279217334659 0.09951300121356615 0.328125 127 32 1.0 0.2246329116307658 0.22463291163076574 0.2246329116307658 0.5390625 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.0008292172512048131 0.05028833052973516 -0.09939434508948572 0.09773591058707609 0.984375 127 32 1.0 0.011071291037147686 0.01107129103714768 0.011071291037147714 0.984375 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.026415166266807275 0.020988571143763835 -0.014722433174969844 0.0675527657085844 0.3203125 127 32 1.0 0.20948529293217255 0.20948529293217255 0.20948529293217266 0.48046875 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.046943715953258976 0.04004634132421383 -0.03154711304220013 0.12543454494871809 0.21875 127 32 1.0 -0.14684120308010876 -0.1468412030801088 -0.14684120308010873 0.328125 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate 197 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.0205285496864516 0.04400917840416313 -0.06572943998570814 0.10678653935861133 0.703125 127 32 1.0 -0.17560312956605126 -0.17560312956605126 -0.1756031295660512 0.7484879032258065 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.05165874490295758 0.117542351799728 -0.1787242646245093 0.28204175443042445 0.7421875 127 32 1.0 0.0947307718109702 0.09473077181097019 0.09473077181097025 0.9420072115384616 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 feedback_core HSC_identity;log_library 8 4 0.08503922534617113 0.03896385829414502 0.008670063089646893 0.16140838760269538 0.21875 127 32 1.0 0.0275268441155858 0.027526844115585793 0.027526844115585817 0.4010416666666667 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.11500543874001516 0.06108590150026164 -0.004722928200497661 0.23473380568052798 0.078125 127 32 1.0 0.019138899192866512 0.019138899192866512 0.01913889919286654 0.234375 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.04508175358775794 0.0727537528188825 -0.18767910911276764 0.09751560193725174 0.6640625 127 32 1.0 0.015658671994304246 0.015658671994304235 0.015658671994304263 0.8211805555555556 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.09236658301170064 0.045887813348420695 0.002426468848796076 0.1823066971746052 0.0390625 127 32 1.0 0.01951046546283956 0.01951046546283954 0.019510465462839563 0.18415178571428573 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.22871409970988454 0.07462540997517607 0.08244829615853946 0.37497990326122965 0.0234375 127 32 1.0 0.15675193988485955 0.1567519398848595 0.15675193988485955 0.14322916666666666 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late 838 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.13634751669818382 0.07867283897138366 -0.017851247685728155 0.2905462810820958 0.15625 127 32 1.0 0.149564510734917 0.149564510734917 0.14956451073491708 0.47879464285714285 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.04523433392725694 0.10711633921775142 -0.2551823587940497 0.16471369093953586 0.59375 127 32 1.0 0.05712048189545312 0.05712048189545311 0.057120481895453136 0.86625 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 feedback_core HSC_identity;log_library 8 4 0.02583714776523989 0.034774360540715435 -0.042320598894562356 0.09399489442504214 0.4375 127 32 1.0 0.02739299893767937 0.02739299893767934 0.027392998937679394 0.6015625 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.0645045744232832 0.03276197627135349 0.000291100931430352 0.12871804791513602 0.0390625 127 32 1.0 0.028353429720646382 0.02835342972064638 0.028353429720646393 0.18415178571428573 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.023917394356700036 0.04322076349121915 -0.10863009079948957 0.06079530208608949 0.609375 127 32 1.0 -0.07406284895766417 -0.07406284895766417 -0.07406284895766414 0.8211805555555556 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.04312104550636595 0.02069129318544298 0.002566110862897715 0.08367598014983418 0.0234375 127 32 1.0 0.07775589589326207 0.07775589589326207 0.07775589589326208 0.1546875 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 -0.021633581318833077 0.05177980307260292 -0.1231219953411348 0.07985483270346866 0.671875 127 32 1.0 -0.006042256640454215 -0.006042256640454223 -0.006042256640454206 0.7645474137931034 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early 624 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.064754626825199 0.057995343929017715 -0.17842550092607373 0.048916247275675714 0.2421875 127 32 1.0 -0.026238207227152647 -0.026238207227152668 -0.02623820722715262 0.49951171875 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.1911860848408652 0.15237607389910943 -0.4898431896831197 0.1074710200013893 0.234375 127 31 0.96875 -0.13130287403449362 -0.13130287403449364 -0.1313028740344936 0.703125 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 feedback_core HSC_identity;log_library 8 4 -0.0010726484874492082 0.05290723222606806 -0.10477082365054259 0.10262552667564419 0.984375 127 31 0.96875 0.05627331616511477 0.056273316165114766 0.05627331616511478 0.9921875 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.02757774335656656 0.028922479496939168 -0.02911031645743421 0.08426580317056732 0.4140625 127 31 0.96875 0.0011446791027114938 0.0011446791027114856 0.0011446791027115045 0.5442708333333334 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.02919114134542132 0.0624937494098195 -0.15167889018866754 0.0932966074978249 0.671875 127 31 0.96875 -0.17020631726652918 -0.1702063172665292 -0.17020631726652916 0.8211805555555556 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.025679052782214287 0.029794222403478784 -0.03271762312860413 0.0840757286930327 0.296875 127 31 0.96875 0.12940818272708288 0.12940818272708288 0.1294081827270829 0.47879464285714285 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 -0.0454336502436358 0.06872807928638576 -0.1801406856449519 0.0892733851576803 0.4375 127 31 0.96875 -0.14779330115825384 -0.14779330115825393 -0.14779330115825384 0.5552884615384616 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early 232 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.07111270302585013 0.08537475826857971 -0.23844722923226636 0.0962218231805661 0.3984375 127 31 0.96875 -0.12800248604667439 -0.12800248604667444 -0.12800248604667439 0.59765625 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.12900187707002836 0.18306945715363995 -0.4878180130911627 0.22981425895110597 0.46875 127 32 1.0 -0.009909691610037833 -0.009909691610037843 -0.009909691610037805 0.86625 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 feedback_core HSC_identity;log_library 8 4 -0.020807066816684077 0.08292192232621635 -0.18333403457606812 0.14171990094269998 0.75 127 32 1.0 -0.01703947988680865 -0.01703947988680866 -0.017039479886808637 0.8839285714285714 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.16273235237759806 0.09383761077514223 -0.021189364741680705 0.3466540694968768 0.078125 127 32 1.0 0.0871739492882766 0.08717394928827657 0.08717394928827661 0.234375 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.22245695656621645 0.10588652984390032 -0.4299945550602611 -0.014919358072171818 0.03125 127 32 1.0 0.08847824619057773 0.08847824619057772 0.08847824619057776 0.2578125 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.09294717136737984 0.060078097992314165 -0.02480590069755592 0.2107002434323156 0.1171875 127 32 1.0 0.0404040154198289 0.04040401541982889 0.04040401541982893 0.3515625 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.19988064436487551 0.1004719980029268 0.0029555282791389748 0.39680576045061206 0.0546875 127 32 1.0 -0.03414030879750064 -0.03414030879750067 -0.03414030879750063 0.14732142857142858 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late 444 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.10693347299749575 0.10065557725817183 -0.09035145842852102 0.30421840442351256 0.296875 127 32 1.0 0.08020860796876815 0.08020860796876812 0.08020860796876815 0.5291940789473685 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.047008368730555646 0.08031032723113415 -0.11039987264246731 0.2044166101035786 0.640625 127 32 1.0 0.1769457193894783 0.17694571938947828 0.1769457193894783 0.86625 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 feedback_core HSC_identity;log_library 8 4 0.03704117031735714 0.03570507920849823 -0.0329407849312994 0.10702312556601368 0.3828125 127 32 1.0 0.12386400824137865 0.12386400824137862 0.12386400824137866 0.6015625 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.034343129010255484 0.041858635938998405 -0.047699797430181386 0.11638605545069236 0.4453125 127 32 1.0 0.04659037964726517 0.04659037964726516 0.04659037964726519 0.5442708333333334 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.014962706153438081 0.055052477319663354 -0.12286556169997825 0.09294014939310208 0.828125 127 32 1.0 0.11015335386968804 0.11015335386968801 0.11015335386968814 0.8981854838709677 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.027279843675143342 0.036231020032911385 -0.043732955589362965 0.09829264293964965 0.46875 127 32 1.0 -0.019333093188187246 -0.019333093188187267 -0.019333093188187243 0.6147836538461539 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.1102659454397178 0.0444343518924903 0.023174615730436804 0.19735727514899878 0.03125 127 32 1.0 0.067650505602618 0.06765050560261797 0.06765050560261801 0.14322916666666666 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate 384 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.08298610176457437 0.05618481848668819 -0.027136142469334476 0.1931083459984832 0.1953125 127 32 1.0 0.1262069808031729 0.12620698080317289 0.12620698080317297 0.47879464285714285 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.08560746076174465 0.1411744719979881 -0.3623094258778013 0.19109450435431202 0.578125 127 32 1.0 -0.09533186988436397 -0.09533186988436397 -0.09533186988436394 0.86625 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 feedback_core HSC_identity;log_library 8 4 0.003487682653994643 0.04806082929716789 -0.09071154276845442 0.0976869080764437 0.9296875 127 32 1.0 0.11123657182569979 0.11123657182569979 0.11123657182569983 0.9896673387096774 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.11990878010117863 0.07826572306677428 -0.03349203710969896 0.27330959731205623 0.109375 127 32 1.0 0.022825845759575518 0.022825845759575504 0.02282584575957552 0.29747596153846156 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.11983168042602153 0.10078636646124504 -0.3173729586900618 0.07770959783801874 0.2421875 127 32 1.0 0.05268297018213896 0.05268297018213893 0.05268297018213897 0.5328125 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.11851991683297745 0.056028813940128035 0.00870344151032651 0.2283363921556284 0.078125 127 32 1.0 -0.04515695490145677 -0.04515695490145678 -0.04515695490145676 0.322265625 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 -0.004584037403847925 0.06497250083000375 -0.13193013903065526 0.12276206422295942 0.9453125 127 32 1.0 -0.10143136857274705 -0.10143136857274707 -0.10143136857274702 0.953125 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early 631 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.12310395423682537 0.10291509803756309 -0.324817546390449 0.07860963791679827 0.2421875 127 32 1.0 -0.1112074131512861 -0.1112074131512861 -0.11120741315128603 0.49951171875 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.05594395696800833 0.17609696281023615 -0.4010940040760712 0.2892060901400545 0.8203125 127 32 1.0 0.11435933856083634 0.11435933856083631 0.11435933856083635 0.966796875 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 feedback_core HSC_identity;log_library 8 4 0.17875776144071473 0.08405740084535694 0.014005255783815118 0.34351026709761434 0.1171875 127 32 1.0 0.06667342308092153 0.06667342308092152 0.06667342308092156 0.24169921875 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.12821777382992966 0.09319771543097354 -0.054449748414778454 0.3108852960746378 0.4140625 127 32 1.0 0.1864937515929698 0.18649375159296977 0.1864937515929698 0.5442708333333334 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.030900825058991242 0.12026660334153863 -0.20482171749042447 0.26662336760840694 0.84375 127 32 1.0 0.06479183834327004 0.06479183834327004 0.06479183834327007 0.8981854838709677 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.056776722760063014 0.09260552325352397 -0.12473010281684396 0.23828354833697 0.6015625 127 32 1.0 0.19739855745312315 0.19739855745312307 0.19739855745312318 0.708984375 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.15077114835056976 0.07105653553085332 0.011500338710097258 0.29004195799104227 0.1484375 127 32 1.0 0.07734030131768736 0.07734030131768735 0.07734030131768736 0.2881433823529412 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late 190 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.09399442559050676 0.10246310335937941 -0.1068332569938769 0.2948221081748904 0.203125 127 32 1.0 0.04283507592110088 0.04283507592110088 0.042835075921100946 0.47879464285714285 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.4025236378788288 0.12843682621801308 -0.6542598172661345 -0.15078745849152314 0.015625 127 32 1.0 0.04410257169243882 0.0441025716924388 0.04410257169243883 0.4296875 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 feedback_core HSC_identity;log_library 8 4 -0.0627299563569568 0.033582808097591815 -0.12855226022823676 0.0030923475143231627 0.078125 127 32 1.0 -0.08830908049626536 -0.08830908049626536 -0.08830908049626535 0.1890625 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 -0.0035685961620387364 0.02503918921235358 -0.05264540701825175 0.04550821469417428 0.9140625 127 32 1.0 0.28224862289479763 0.28224862289479763 0.2822486228947978 0.9140625 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.0680967048845851 0.03693007083661529 -0.14047964372435107 0.004286233955180879 0.0546875 127 32 1.0 -0.044273196977764606 -0.04427319697776461 -0.044273196977764585 0.2578125 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 -0.00625420948083049 0.025717610887000926 -0.0566607268193523 0.04415230785769132 0.7578125 127 32 1.0 0.01917805214527983 0.01917805214527983 0.01917805214527986 0.781494140625 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 -0.06794821075557923 0.06495253642323555 -0.1952551821451209 0.059358760633962435 0.2890625 127 32 1.0 0.05269304929384314 0.05269304929384312 0.05269304929384314 0.3974609375 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early 394 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.061694001274748694 0.07259316096373601 -0.20397659676367128 0.08058859421417389 0.3671875 127 32 1.0 0.06381734076983821 0.06381734076983818 0.06381734076983821 0.5770089285714286 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.011446324012200575 0.1340295685607163 -0.27414427839120453 0.25125163036680337 0.953125 127 28 0.875 0.17075503420604732 0.17075503420604726 0.17075503420604735 0.984375 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 feedback_core HSC_identity;log_library 8 4 -0.016457605741562974 0.05823841667243447 -0.13060490241953454 0.09768969093640859 0.8046875 127 28 0.875 0.21132772159955732 0.2113277215995573 0.21132772159955734 0.9156788793103449 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.11103882562120987 0.052718796979576425 0.007709983541240084 0.21436766770117965 0.078125 127 28 0.875 -0.13089119136387092 -0.13089119136387092 -0.1308911913638709 0.234375 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.1200302702119677 0.08492984010678045 -0.2864927568212574 0.04643221639732199 0.1953125 127 28 0.875 0.1517648672273249 0.15176486722732485 0.1517648672273249 0.4957932692307692 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.08117505312293091 0.0449821413684139 -0.006989943959160333 0.16934005020502216 0.1328125 127 28 0.875 -0.07717757136810144 -0.07717757136810145 -0.07717757136810142 0.35697115384615385 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.027340788179863143 0.0912303396460778 -0.15147067752644933 0.20615225388617564 0.7890625 127 28 0.875 0.05840914622521842 0.058409146225218395 0.05840914622521844 0.86796875 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early 163 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.053834264943067804 0.09978131691219176 -0.24940564609096366 0.14173711620482804 0.5234375 127 28 0.875 0.047305837265286185 0.04730583726528617 0.04730583726528621 0.6397569444444444 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.10209990529289391 0.08940411069017844 -0.07313215165985583 0.27733196224564366 0.2265625 127 30 0.9375 0.004970750908794345 0.004970750908794323 0.004970750908794345 0.703125 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 feedback_core HSC_identity;log_library 8 4 0.055904642655293206 0.03302104848181551 -0.00881661236906519 0.1206258976796516 0.0625 127 30 0.9375 -0.05173181762276801 -0.05173181762276803 -0.05173181762276801 0.1890625 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.032058402444132064 0.028419447140645145 -0.02364371395153242 0.08776051883979655 0.359375 127 30 0.9375 -0.12714597685506215 -0.12714597685506215 -0.12714597685506213 0.5390625 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.019074151010292077 0.04081910102779313 -0.06093128700418247 0.09907958902476663 0.6484375 127 30 0.9375 -0.10651740248656931 -0.10651740248656934 -0.10651740248656931 0.8211805555555556 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.029255231072908422 0.022103073706745906 -0.01406679339231355 0.0725772555381304 0.296875 127 30 0.9375 -0.13408300492932637 -0.13408300492932637 -0.13408300492932632 0.47879464285714285 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.11671337487486516 0.05514923290912168 0.008620878372986668 0.22480587137674365 0.0390625 127 30 0.9375 -0.1369096720722647 -0.1369096720722647 -0.13690967207226468 0.14322916666666666 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early 508 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.08745814380195673 0.04772012998764214 -0.006073310973821869 0.18098959857773533 0.046875 127 30 0.9375 -0.04258999252010532 -0.04258999252010534 -0.04258999252010529 0.38671875 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.47968006653488116 0.23424789828450404 0.02055418589725322 0.9388059471725091 0.1171875 127 28 0.875 -0.014800646926506109 -0.014800646926506133 -0.014800646926506103 0.703125 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 feedback_core HSC_identity;log_library 8 4 0.23728238432990267 0.08116081546887162 0.07820718601091431 0.39635758264889104 0.015625 127 28 0.875 -0.006375708826645067 -0.0063757088266451 -0.006375708826645051 0.103125 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 -0.032640310900895565 0.06959401217142504 -0.16904457475688864 0.10376395295509752 0.6015625 127 28 0.875 0.10878491201289478 0.10878491201289477 0.10878491201289478 0.6486895161290323 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.26409097690440847 0.11076743462760182 0.04698680503430891 0.48119514877450803 0.0546875 127 28 0.875 0.0497532915614363 0.049753291561436284 0.04975329156143632 0.2578125 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 -0.017412913755626258 0.04920606432670834 -0.1138567998359746 0.07903097232472209 0.671875 127 28 0.875 0.03531178358321055 0.03531178358321051 0.035311783583210556 0.74765625 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.2635211638317101 0.11229771537537153 0.04341764169598189 0.4836246859674383 0.03125 127 28 0.875 0.001048478424831905 0.0010484784248318865 0.0010484784248319175 0.14322916666666666 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early 306 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.28093407758733624 0.11183975850875984 0.06172815091016695 0.5001400042645056 0.03125 127 28 0.875 0.037914521190959574 0.03791452119095955 0.03791452119095959 0.38671875 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.1277143363663086 0.11758087870770992 -0.3581728586334201 0.10274418590080284 0.3515625 127 32 1.0 -0.1519857682457717 -0.15198576824577173 -0.15198576824577167 0.8286830357142857 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 feedback_core HSC_identity;log_library 8 4 -0.053691908414552486 0.047358677134656135 -0.1465149155984785 0.03913109876937354 0.40625 127 32 1.0 -0.07162023730081411 -0.07162023730081411 -0.0716202373008141 0.6015625 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.03633194536320113 0.04553178574276594 -0.0529103546926201 0.12557424541902237 0.4921875 127 32 1.0 -0.1718718711272387 -0.17187187112723873 -0.1718718711272387 0.580078125 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.07829936093316743 0.05773066498195831 -0.1914514642978057 0.03485274243147085 0.1796875 127 32 1.0 -0.16212240206381584 -0.1621224020638159 -0.1621224020638158 0.494140625 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.011799953957425946 0.0315473800570679 -0.050032910954427134 0.07363281886927903 0.7578125 127 32 1.0 -0.13330544887810306 -0.13330544887810306 -0.133305448878103 0.781494140625 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 -0.07693997907808184 0.05147924655065703 -0.1778393023173696 0.023959344161205945 0.3125 127 32 1.0 -0.011735232396012393 -0.011735232396012405 -0.011735232396012363 0.4125 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early 421 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.08873993303550783 0.05735064604882488 -0.2011471992912046 0.023667333220188935 0.125 127 32 1.0 -0.24795867454271112 -0.24795867454271112 -0.24795867454271112 0.47879464285714285 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.003587738237577427 0.06199962739384292 -0.12510700792950954 0.1179315314543547 0.9609375 127 32 1.0 -0.009636563047321722 -0.009636563047321757 -0.009636563047321717 0.984375 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 feedback_core HSC_identity;log_library 8 4 0.06670277465196767 0.042364014227749026 -0.01633069323442042 0.14973624253835577 0.0859375 127 32 1.0 0.04796722775433066 0.04796722775433063 0.04796722775433068 0.1890625 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.02117464399567826 0.035864014857094714 -0.04911882512422738 0.0914681131155839 0.609375 127 32 1.0 -0.2536838011501474 -0.2536838011501474 -0.2536838011501473 0.6486895161290323 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.04018303262296451 0.0520236439811479 -0.06178330958008538 0.1421493748260144 0.296875 127 32 1.0 -0.2971057505907371 -0.2971057505907372 -0.29710575059073707 0.5442708333333334 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.03982760243414565 0.03089925461382056 -0.020734936608942656 0.10039014147723395 0.3046875 127 32 1.0 -0.14992403386253073 -0.14992403386253075 -0.1499240338625307 0.47879464285714285 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.06576672083983572 0.03564651385754435 -0.004100446320951218 0.13563388800062265 0.0625 127 32 1.0 -0.11170653971267078 -0.1117065397126708 -0.11170653971267072 0.14732142857142858 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate 575 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.0259391184056899 0.03756172205586971 -0.04768185682381473 0.09956009363519452 0.1796875 127 32 1.0 -0.3786077698611277 -0.37860776986112776 -0.37860776986112765 0.47879464285714285 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.5319343793220471 0.26596679531821166 0.010639460498352293 1.0532292981457418 0.0390625 127 32 1.0 -0.09863771268275241 -0.09863771268275243 -0.0986377126827524 0.4296875 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 feedback_core HSC_identity;log_library 8 4 0.38234975177149 0.07845885024621643 0.2285704052889058 0.5361290982540742 0.0078125 127 32 1.0 0.0421766712362081 0.04217667123620809 0.04217667123620813 0.0859375 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.15335713595590728 0.07123544856988893 0.013735656758924963 0.2929786151528896 0.0234375 127 32 1.0 -0.013390153213236245 -0.013390153213236257 -0.013390153213236236 0.12890625 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.07067382868179117 0.08607102632854319 -0.09802538292215346 0.2393730402857358 0.2734375 127 32 1.0 -0.3103719900899692 -0.31037199008996924 -0.31037199008996913 0.5442708333333334 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.07609147050973673 0.06670093336648898 -0.05464235888858167 0.20682529990805515 0.1796875 127 32 1.0 -0.13774835122619025 -0.13774835122619028 -0.13774835122619022 0.3943014705882353 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.4279714751510662 0.140161832483785 0.1532542834828476 0.7026886668192849 0.03125 127 32 1.0 0.026675846600351872 0.02667584660035185 0.026675846600351882 0.14322916666666666 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late 582 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.35188000464132907 0.13893021073290288 0.07957679160483944 0.6241832176778187 0.046875 127 32 1.0 -0.07760952106447404 -0.07760952106447404 -0.07760952106447401 0.38671875 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.3970840754073653 0.25976857261323794 -0.11206232691458101 0.9062304777293115 0.1875 127 31 0.96875 0.14986118040999388 0.14986118040999385 0.14986118040999388 0.703125 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 feedback_core HSC_identity;log_library 8 4 0.28379473028316243 0.10483557639735429 0.07831700054434804 0.48927246002197683 0.03125 127 31 0.96875 0.10585165227649727 0.10585165227649723 0.10585165227649727 0.12890625 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 -0.04880736467659075 0.09007873162514637 -0.22536167866187765 0.12774694930869615 0.5625 127 31 0.96875 0.048339421394993067 0.04833942139499304 0.048339421394993067 0.6400862068965517 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.33053414249487223 0.14867796034815037 0.03912534021249753 0.6219429447772469 0.046875 127 31 0.96875 0.05535269520098888 0.05535269520098884 0.0553526952009889 0.2578125 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 -0.018248930496880582 0.05606453772186896 -0.12813542443174375 0.09163756343798257 0.6796875 127 31 0.96875 0.0022211257820239413 0.002221125782023931 0.0022211257820239573 0.74765625 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.2827488744751751 0.13355250006831712 0.020985974341273528 0.5445117746090766 0.046875 127 31 0.96875 0.19150765576207082 0.19150765576207082 0.19150765576207088 0.14732142857142858 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late 83 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.30099780497205586 0.14603910334145193 0.014761162422810115 0.5872344475213016 0.0703125 127 31 0.96875 0.13941858934456564 0.1394185893445656 0.13941858934456566 0.4640625 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.0747695368467206 0.1536223645139309 -0.22633029760058399 0.3758693712940252 0.53125 127 32 1.0 0.1505048524021716 0.15050485240217154 0.1505048524021716 0.86625 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 feedback_core HSC_identity;log_library 8 4 0.21410018695736996 0.0807848311153848 0.05576191797121574 0.3724384559435242 0.015625 127 32 1.0 0.2614219648809154 0.2614219648809153 0.2614219648809154 0.103125 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.2744927892783542 0.0824822165005051 0.11282764493736419 0.4361579336193442 0.0078125 127 32 1.0 0.04614871447086766 0.04614871447086764 0.046148714470867665 0.064453125 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.11461743878426711 0.08423321818800712 -0.27971454643276106 0.050479668864226834 0.046875 127 32 1.0 0.008646586476282851 0.008646586476282827 0.008646586476282858 0.2578125 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.14836071073009224 0.05770649343012632 0.035255983607044655 0.2614654378531398 0.0078125 127 32 1.0 0.05951755576445823 0.059517555764458226 0.05951755576445827 0.12890625 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.24751705946881103 0.10783712080266498 0.03615630269558767 0.4588778162420344 0.0390625 127 32 1.0 0.16346563084279542 0.1634656308427954 0.16346563084279545 0.14322916666666666 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late 339 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.09915634873871888 0.08634895261806302 -0.07008759839268465 0.26840029587012243 0.2734375 127 32 1.0 0.16142583031304913 0.16142583031304908 0.16142583031304913 0.5291940789473685 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.08804121452915396 0.08380187442113105 -0.2522928883945708 0.07621045933626287 0.21875 127 32 1.0 -0.04577279458151669 -0.045772794581516695 -0.04577279458151667 0.703125 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 feedback_core HSC_identity;log_library 8 4 0.05236852905293104 0.04055281129702053 -0.027114981089229197 0.13185203919509128 0.4609375 127 32 1.0 0.1774735916948717 0.17747359169487167 0.17747359169487176 0.6084375 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.037537553863022294 0.04919811204344918 -0.058890745742138095 0.13396585346818268 0.3984375 127 32 1.0 0.11391857921420713 0.11391857921420713 0.11391857921420716 0.5442708333333334 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.03527793082137852 0.06531115383462817 -0.16328779233724972 0.09273193069449269 0.5625 127 32 1.0 0.024699766676800426 0.024699766676800412 0.024699766676800447 0.8211805555555556 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.03862656674627933 0.04181522863720003 -0.04333128138263273 0.12058441487519139 0.3515625 127 32 1.0 0.007986838242219045 0.007986838242219029 0.007986838242219064 0.5044157608695652 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.06720967984426258 0.03882840060282828 -0.008893985337280835 0.143313345025806 0.078125 127 32 1.0 0.0365169512664112 0.0365169512664112 0.03651695126641122 0.171875 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate 620 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.02858311309798325 0.050667658791840764 -0.07072549813402464 0.12789172432999113 0.4921875 127 32 1.0 0.016607324038452848 0.01660732403845283 0.016607324038452862 0.6246995192307693 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.10250843351529963 0.10449347720865335 -0.3073156488442602 0.10229878181366094 0.3125 127 32 1.0 -0.14785342138722624 -0.14785342138722626 -0.14785342138722624 0.8286830357142857 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 feedback_core HSC_identity;log_library 8 4 0.027387584488845904 0.04291214171065819 -0.05672021326404415 0.11149538224173595 0.5 127 32 1.0 -0.18401834816565665 -0.1840183481656567 -0.18401834816565663 0.6346153846153846 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.12857161373592943 0.04826443820947222 0.03397331484536388 0.223169912626495 0.0078125 127 32 1.0 -0.17255802649960092 -0.17255802649960092 -0.1725580264996009 0.064453125 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.12831096875142334 0.05718698061548608 -0.24039745075777605 -0.016224486745070626 0.046875 127 32 1.0 -0.37373547693994397 -0.373735476939944 -0.3737354769399439 0.2578125 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.06950458349879383 0.03388158485597608 0.003096677181080712 0.13591248981650694 0.0234375 127 32 1.0 -0.07628308868396794 -0.07628308868396795 -0.07628308868396794 0.1546875 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.022418364323130675 0.0816891833177522 -0.13769243497966363 0.182529163625925 0.671875 127 32 1.0 -0.07219183989382257 -0.07219183989382257 -0.07219183989382254 0.7645474137931034 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early 608 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.047086219175663094 0.08886086332648467 -0.22125351129557302 0.12708107294424686 0.4921875 127 32 1.0 -0.1363637976388961 -0.13636379763889617 -0.13636379763889608 0.6246995192307693 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.056260525083197725 0.056145656338972644 -0.16630601150758412 0.05378496134118866 0.3515625 127 32 1.0 0.019196530543658864 0.01919653054365882 0.019196530543658878 0.8286830357142857 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 feedback_core HSC_identity;log_library 8 4 0.031525160631804286 0.02779245264238379 -0.022948046547267946 0.08599836781087652 0.0703125 127 32 1.0 -0.06678941650721965 -0.06678941650721966 -0.06678941650721963 0.1890625 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.025114124620236343 0.029125305503359813 -0.031971474166348886 0.08219972340682158 0.25 127 32 1.0 0.030788145212743222 0.030788145212743204 0.03078814521274323 0.515625 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.005529832396635348 0.03735131171202373 -0.07873840335220186 0.06767873855893117 0.8125 127 32 1.0 -0.0024432840157542195 -0.0024432840157542447 -0.0024432840157542148 0.8981854838709677 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.02132746746198671 0.02001445556222116 -0.01790086543996676 0.060555800363940177 0.2265625 127 32 1.0 -0.050869273776458786 -0.05086927377645879 -0.05086927377645877 0.4153645833333333 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.05087107576266394 0.03276973904605591 -0.013357612767605644 0.11509976429293353 0.171875 127 32 1.0 -0.03908166844213374 -0.03908166844213375 -0.03908166844213372 0.3151041666666667 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate 334 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.02954360830067718 0.036181437863925386 -0.04137200991261658 0.10045922651397093 0.453125 127 32 1.0 -0.14096897206585118 -0.14096897206585124 -0.14096897206585118 0.6246995192307693 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.11183259725470956 0.19483947215127562 -0.27005276816179064 0.49371796267120976 0.5234375 127 32 1.0 0.2335938106510854 0.23359381065108537 0.23359381065108548 0.86625 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 feedback_core HSC_identity;log_library 8 4 0.21032914775920858 0.05390079618487591 0.1046835872368518 0.3159747082815654 0.0078125 127 32 1.0 -0.11448867391510026 -0.11448867391510029 -0.11448867391510023 0.0859375 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.12790622786369266 0.0792890800868399 -0.027500369106513545 0.28331282483389886 0.15625 127 32 1.0 0.031243862190315587 0.031243862190315577 0.031243862190315594 0.34375 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.09536629176511258 0.09028945724478511 -0.08160104443466623 0.27233362796489136 0.2890625 127 32 1.0 -0.07111827061163144 -0.07111827061163147 -0.07111827061163144 0.5442708333333334 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.10026656599010163 0.06304173704424654 -0.023295238616621583 0.22382837059682484 0.140625 127 32 1.0 0.05635513684717797 0.05635513684717794 0.05635513684717801 0.35697115384615385 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.18723167476217448 0.07135974997532658 0.04736656481053439 0.32709678471381454 0.015625 127 32 1.0 0.08288249247368956 0.08288249247368952 0.08288249247368958 0.14322916666666666 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late 465 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.08696510877207282 0.09191232293079274 -0.09318304417228095 0.2671132617164266 0.3359375 127 32 1.0 -0.000464744782730756 -0.00046474478273075793 -0.0004647447827307308 0.554296875 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.10017758952130396 0.14824926580810002 -0.19039097146257206 0.39074615050517997 0.484375 127 32 1.0 -0.0016882562566035762 -0.0016882562566035784 -0.0016882562566035506 0.86625 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 feedback_core HSC_identity;log_library 8 4 0.1049574671158606 0.0610876794209963 -0.014774384549292141 0.22468931878101334 0.0859375 127 32 1.0 -0.07094360905088835 -0.07094360905088837 -0.07094360905088833 0.1890625 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.07312286014043315 0.07532664752363123 -0.07451736900588407 0.22076308928675037 0.3515625 127 32 1.0 0.11468533234116222 0.11468533234116221 0.11468533234116227 0.5390625 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 0.05648607624664718 0.09536642825492818 -0.13043212313301206 0.2434042756263064 0.5546875 127 32 1.0 0.18432735320054167 0.18432735320054158 0.18432735320054167 0.8211805555555556 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.08287461605385245 0.05566036627133832 -0.026219701837970663 0.19196893394567555 0.109375 127 32 1.0 -0.10303910425193236 -0.1030391042519324 -0.10303910425193236 0.3515625 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.09177771222153618 0.05710202847508242 -0.020142263589625356 0.20369768803269772 0.1953125 127 32 1.0 0.009775999986419126 0.00977599998641912 0.009775999986419159 0.322265625 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late 590 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.008903096167683673 0.07444602063864685 -0.13701110428406416 0.1548172966194315 0.9375 127 32 1.0 -0.011994419339103815 -0.011994419339103835 -0.011994419339103793 0.9375 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.42458001498994685 0.25363192204751034 -0.0725385522231734 0.9216985822030671 0.2265625 127 23 0.71875 0.3352818626522703 0.3352818626522702 0.3352818626522704 0.703125 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 feedback_core HSC_identity;log_library 8 4 0.12930183645008342 0.08502598405409212 -0.037349092295937136 0.295952765196104 0.1328125 127 23 0.71875 0.11924941073513816 0.11924941073513812 0.11924941073513816 0.2578125 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.10717510700619291 0.09028856865584134 -0.06979048755925611 0.28414070157164195 0.4375 127 23 0.71875 0.2649706021283484 0.2649706021283484 0.2649706021283485 0.5442708333333334 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.021468760088839408 0.14479667651472222 -0.305270246057695 0.26233272588001616 0.921875 127 23 0.71875 0.29718056663545034 0.2971805666354503 0.2971805666354504 0.95068359375 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.059902670153955756 0.07867671499403309 -0.09430369123434909 0.2141090315422606 0.5703125 127 23 0.71875 0.27958661572616345 0.27958661572616345 0.27958661572616356 0.6970486111111112 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.29164536247176803 0.13549321280414553 0.026078665375642796 0.5572120595678933 0.0625 127 23 0.71875 0.23568658398583905 0.23568658398583903 0.2356865839858391 0.14732142857142858 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late 117 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.23174269231781214 0.13359963070392183 -0.030112583861874653 0.49359796849749893 0.15625 127 23 0.71875 0.22678945248644508 0.226789452486445 0.22678945248644514 0.47879464285714285 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.001679294579748058 0.07917420199139041 -0.15350214132337717 0.15686073048287327 0.96875 127 32 1.0 -0.13984126287040952 -0.13984126287040952 -0.1398412628704095 0.984375 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 feedback_core HSC_identity;log_library 8 4 0.0801900479179214 0.028697377060968633 0.023943188878422887 0.13643690695741992 0.0234375 127 32 1.0 0.10611860335545974 0.10611860335545974 0.10611860335545975 0.11049107142857142 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.06434617501494204 0.046039501185569244 -0.02589124730877368 0.15458359733865776 0.15625 127 32 1.0 0.11039873059411441 0.11039873059411441 0.11039873059411442 0.34375 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.014966666675554841 0.04268200918724983 -0.0986234046825645 0.06869007133145483 0.7578125 127 32 1.0 -0.20696530426750984 -0.20696530426750986 -0.2069653042675097 0.8931361607142857 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.048488361814028116 0.034263190436222724 -0.018667491440968423 0.11564421506902466 0.203125 127 32 1.0 0.0734463275687168 0.07344632756871679 0.07344632756871682 0.3943014705882353 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.11329959396956929 0.07417004928140569 -0.03207370262198586 0.2586728905611244 0.1015625 127 32 1.0 -0.10106392093783667 -0.1010639209378367 -0.10106392093783664 0.20947265625 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late 361 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.0648112321555411 0.06656738893700141 -0.06566085016098167 0.19528331447206387 0.3046875 127 32 1.0 -0.1816491874276758 -0.1816491874276758 -0.18164918742767577 0.5291940789473685 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.11740275602762215 0.06536665134740385 -0.2455213926685337 0.010715880613289402 0.03125 127 32 1.0 0.13978303090768 0.1397830309076799 0.13978303090768 0.4296875 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 feedback_core HSC_identity;log_library 8 4 -0.031070697022512393 0.03562351924227061 -0.10089279473736279 0.03875140069233801 0.296875 127 32 1.0 0.027361427052848285 0.027361427052848254 0.027361427052848292 0.515625 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.034138697054581606 0.03256852863658813 -0.029695619073131126 0.09797301318229434 0.2890625 127 32 1.0 0.005928584610398676 0.0059285846103986585 0.005928584610398692 0.5291940789473685 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.06502355330421289 0.03858587906588904 -0.1406518762733554 0.010604769664929625 0.0625 127 32 1.0 0.13847997281290098 0.1384799728129009 0.13847997281290098 0.2578125 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.022932976960082067 0.023200651703883603 -0.022540300379529792 0.06840625429969392 0.390625 127 32 1.0 -0.006414166510627342 -0.006414166510627359 -0.006414166510627337 0.537109375 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 -0.007831074774987562 0.037546273590050736 -0.08142177101148701 0.06575962146151187 0.8515625 127 32 1.0 0.10368129150580699 0.10368129150580699 0.10368129150580704 0.9065020161290323 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early 405 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.030764051735069672 0.037933190985599254 -0.10511310606684421 0.043585002596704864 0.46875 127 32 1.0 -0.013108060439737437 -0.013108060439737463 -0.013108060439737428 0.6246995192307693 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.0515227193268502 0.09645993429879424 -0.24058419055248692 0.1375387518987865 0.640625 127 29 0.90625 -0.0412558304569402 -0.04125583045694023 -0.0412558304569402 0.86625 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 feedback_core HSC_identity;log_library 8 4 0.028674146272952856 0.04165858109726343 -0.05297667267768347 0.11032496522358917 0.59375 127 29 0.90625 0.007345541809772322 0.007345541809772312 0.007345541809772331 0.7256944444444444 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.05537602471855672 0.043106373925011994 -0.029112468174466784 0.13986451761158022 0.3046875 127 29 0.90625 0.2334579735786259 0.23345797357862583 0.2334579735786259 0.5291940789473685 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.022978334549312307 0.0526555588132701 -0.1261832298233217 0.0802265607246971 0.5859375 127 29 0.90625 0.006502479496399032 0.006502479496399017 0.00650247949639905 0.8211805555555556 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.06683377999117739 0.03719437916706914 -0.006067203176278138 0.13973476315863292 0.15625 127 29 0.90625 0.20069475285009492 0.20069475285009486 0.20069475285009492 0.36830357142857145 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.0012318967367760995 0.04927925513197533 -0.09535544332189555 0.09781923679544774 0.953125 127 29 0.90625 0.14015445834297657 0.14015445834297657 0.14015445834297657 0.953125 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early 189 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 -0.0656018832544012 0.05611420589400095 -0.17558572680664306 0.04438196029784067 0.1953125 127 29 0.90625 0.1622342568514921 0.16223425685149206 0.1622342568514921 0.47879464285714285 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 0.023032962725602246 0.0891678001845428 -0.15173592563610167 0.19780185108730614 0.8203125 127 32 1.0 0.0442419838045618 0.04424198380456177 0.0442419838045618 0.966796875 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 feedback_core HSC_identity;log_library 8 4 0.08889020904470885 0.03837451526607273 0.0136761591232063 0.1641042589662114 0.0234375 127 32 1.0 0.049866206617236716 0.0498662066172367 0.049866206617236744 0.11049107142857142 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.11267689347212016 0.0353742623153554 0.04334333933402358 0.18201044761021673 0.0078125 127 32 1.0 0.07562999974879378 0.07562999974879377 0.07562999974879381 0.064453125 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.026317018638685446 0.049003907521261776 -0.12236467738035853 0.06973064010298763 0.578125 127 32 1.0 -0.16049712833983945 -0.16049712833983948 -0.16049712833983942 0.8211805555555556 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.06165144657391861 0.02826777280501558 0.006246611876088083 0.11705628127174914 0.0390625 127 32 1.0 0.09903007565325789 0.09903007565325787 0.09903007565325792 0.18415178571428573 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.10069622055813683 0.055483134065221464 -0.008050722209697242 0.2094431633259709 0.28125 127 32 1.0 0.35725990287362813 0.3572599028736281 0.3572599028736282 0.3974609375 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late 284 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.03904477398421825 0.06489981237963685 -0.08815885827986998 0.1662484062483065 0.6953125 127 32 1.0 0.30708696744383146 0.3070869674438314 0.3070869674438315 0.7484879032258065 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 mechanical_barrier HSC_identity;Myeloid_identity;log_library 8 4 -0.001273461917682923 0.2088820250425218 -0.41068223100102563 0.4081353071656598 0.9765625 127 32 1.0 -0.012612458186335487 -0.012612458186335503 -0.012612458186335468 0.984375 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 feedback_core HSC_identity;log_library 8 4 0.28125008633741383 0.061307951949403236 0.1610865005165835 0.4014136721582442 0.0078125 127 32 1.0 0.24036550236710688 0.24036550236710683 0.24036550236710688 0.0859375 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 proteolysis HSC_identity;Myeloid_identity;log_library 8 4 0.24958573849564988 0.0676021381518574 0.11708554771800939 0.3820859292732904 0.0078125 127 32 1.0 -0.0033184621169616555 -0.0033184621169616625 -0.0033184621169616312 0.064453125 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 feedback_lock HSC_identity;Myeloid_identity;log_library 8 4 -0.11989459293754184 0.0992722046005771 -0.314468113954673 0.07467892807958929 0.21875 127 32 1.0 -0.04344231643042218 -0.04344231643042219 -0.04344231643042215 0.515625 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 protease_activation_potential HSC_identity;Myeloid_identity;log_library 8 4 0.1706223489834399 0.06562730342356259 0.04199283427325723 0.29925186369362256 0.015625 127 32 1.0 -0.06501758777491301 -0.06501758777491302 -0.065017587774913 0.1546875 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 antiproteolytic_brake HSC_identity;Myeloid_identity;log_library 8 4 0.3212064481977953 0.0928892819344654 0.13914345560624314 0.5032694407893474 0.015625 127 32 1.0 0.3360191327184188 0.3360191327184187 0.3360191327184188 0.14322916666666666 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late 444 clearance_inefficiency HSC_identity;Myeloid_identity;log_library 8 4 0.15058409921435537 0.12019343700999148 -0.08499503732522792 0.3861632357539386 0.1328125 127 32 1.0 0.19499723186749615 0.19499723186749615 0.19499723186749626 0.47879464285714285 diff --git a/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_cross_module_correlations.tsv b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_cross_module_correlations.tsv new file mode 100644 index 0000000..034aefc --- /dev/null +++ b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_cross_module_correlations.tsv @@ -0,0 +1,133 @@ +biopsy_id patient_cluster array fibrosis_stage stage_numeric stage_group target partial_r fisher_z n_blocks nominal_p +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late HSC_retention -0.06026187391938851 -0.06033498014325849 18 0.8378522798473423 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late TGFb_integrator 0.206245115482637 0.2092464496967743 18 0.47930955826913213 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late Endo_resolver -0.22983394557275974 -0.2340141444777258 18 0.42926382209337743 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late LAM_resolver -0.22990309305171092 -0.23408714950868667 18 0.4291211341010799 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early HSC_retention 0.20852975501456886 0.21163376793275485 18 0.47434536881351147 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early TGFb_integrator 0.3051532573212416 0.3151922221525355 18 0.2887362123495201 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early Endo_resolver -0.497065957977646 -0.5454017056164863 18 0.07055831041556457 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early LAM_resolver 0.2906545822868118 0.29928109944440273 18 0.3133970501384081 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early HSC_retention 0.06304112609729987 0.06312483813641238 18 0.8304706787415661 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early TGFb_integrator -0.0953143714973915 -0.09560459338596201 18 0.7458454665086667 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early Endo_resolver -0.10081321316106305 -0.10115684283113538 18 0.7316621970568227 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early LAM_resolver -0.4541563197856767 -0.4899242638520751 18 0.10282470964438634 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early HSC_retention 0.22651185431394283 0.23050959223177897 18 0.4361471952594882 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early TGFb_integrator 0.03915083607707125 0.03917085780386299 18 0.8942877137497298 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early Endo_resolver 0.01575979027911585 0.015761095231824868 18 0.9573554100650047 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early LAM_resolver -0.23757954557426353 -0.2422072953269596 18 0.4134303242144748 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late HSC_retention -0.030848600074322254 -0.030858391212919323 18 0.9166241733444561 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late TGFb_integrator 0.3445365537849086 0.3592310630346896 18 0.227693954302706 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late Endo_resolver 0.03241492518861034 0.032426285434468176 18 0.912405256693868 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late LAM_resolver -0.037850039567997776 -0.03786813009794604 18 0.8977829875606963 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate HSC_retention 0.24190282133956106 0.24679421714090913 18 0.40472536304100015 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate TGFb_integrator -0.13416961219800236 -0.13498350530219277 18 0.647463218108853 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate Endo_resolver -0.4654708539694002 -0.5042728066685171 18 0.09348423666003151 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate LAM_resolver -0.23960036303919835 -0.24435009279964326 18 0.4093494732978384 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late HSC_retention 0.4621044119572947 0.4999837939551082 18 0.09619906279772235 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late TGFb_integrator 0.06374827060841382 0.06383483607964763 18 0.8285945749169156 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late Endo_resolver 0.3863864194621013 0.4075452802229466 18 0.17236407842431872 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late LAM_resolver 0.19205295175832676 0.19446787361771242 18 0.5106886809745371 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early HSC_retention -0.19056410039266092 -0.19292246145749053 18 0.5140335559919229 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early TGFb_integrator -0.22944080995031602 -0.23359912340766717 18 0.4300755247080344 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early Endo_resolver -0.2874734671440378 -0.29580993686827095 18 0.318963739861184 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early LAM_resolver -0.42625654762530524 -0.4553130713184865 18 0.1285593621173276 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early HSC_retention 0.6212532635857851 0.7270435042880999 18 0.017720959927148148 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early TGFb_integrator 0.09197709991694396 0.09223779333693861 18 0.7544902906231385 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early Endo_resolver -0.03279708712492056 -0.03280885410396176 18 0.9113762200521944 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early LAM_resolver 0.018977490152236397 0.01897976886155797 18 0.9486581638099603 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late HSC_retention 0.07989127584468655 0.08006190152310796 18 0.7860148738094965 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late TGFb_integrator 0.05979505230196179 0.05986647028108731 18 0.839093375741311 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late Endo_resolver -0.09970576665472893 -0.10003815115590424 18 0.7345124132928161 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late LAM_resolver -0.08223466058036492 -0.08242078809361547 18 0.7798769761998842 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate HSC_retention -0.1108694214889139 -0.11132707156327028 18 0.7059317249986663 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate TGFb_integrator -0.2272078753586941 -0.23124337788339028 18 0.4347004852740107 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate Endo_resolver -0.5669542612752508 -0.6430228493135584 18 0.03449758667139153 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate LAM_resolver 0.04973043576338594 0.04977149308713758 18 0.8659314048891664 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early HSC_retention 0.39672522081979805 0.4197564338922342 18 0.16018594929658314 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early TGFb_integrator -0.13203752952824385 -0.1328129672825746 18 0.6527413556591987 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early Endo_resolver -0.006930949639838309 -0.006931060626168876 18 0.981239204820218 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early LAM_resolver -0.0030469534869368357 -0.0030469629162191373 18 0.991751929318242 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late HSC_retention 0.18999595399929953 0.19233297169130203 18 0.5153125646117838 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late TGFb_integrator -0.24442317923754203 -0.24947296656478948 18 0.3996949107480151 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late Endo_resolver 0.04204466825301254 0.04206946944240342 18 0.8865183905529839 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late LAM_resolver 0.3522994645924966 0.36806663836912307 18 0.21669155872359458 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early HSC_retention 0.44672029951195863 0.48059537498928645 18 0.10930247788567554 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early TGFb_integrator 0.11090510366173796 0.11136319794555306 18 0.7058409265021546 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early Endo_resolver -0.0061652192092056446 -0.006165297324166343 18 0.9833116161634428 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early LAM_resolver -0.3640009489992522 -0.38149023147429895 18 0.2007457955011818 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early HSC_retention 0.5334971768728851 0.5950210352971704 18 0.04944777891666957 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early TGFb_integrator 0.8817708805037718 1.3836720688539992 18 3.0421867921465524e-05 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early Endo_resolver -0.22192309693734716 -0.2256779196019158 18 0.44574515418214117 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early LAM_resolver -0.41485624101835133 -0.44146282478568033 18 0.14022151179914882 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early HSC_retention 0.40206287494686827 0.4261071534137529 18 0.15412563499499557 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early TGFb_integrator 0.5766549663730496 0.6574366214969204 18 0.030870379978495285 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early Endo_resolver 0.06312114229346338 0.06320517400748685 18 0.8302583478685273 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early LAM_resolver 0.036459663608846865 0.036475831869231076 18 0.9015208681300714 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early HSC_retention 0.7706671237112002 1.0219685521358268 17 0.002047054589768388 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early TGFb_integrator 0.5693454461961902 0.6465538143613377 17 0.04225928113623114 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early Endo_resolver -0.7376432425817353 -0.9452898843746282 17 0.004002585451034912 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early LAM_resolver 0.3172868040102974 0.3286272976884008 17 0.290816083804917 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early HSC_retention 0.47430598193259144 0.515611654272659 18 0.08661375188533076 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early TGFb_integrator -0.12064242505709313 -0.1212328906251666 18 0.6812023856684479 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early Endo_resolver -0.49132076410935166 -0.5377998960788789 18 0.07439332591883184 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early LAM_resolver 0.021259633331556282 0.021262837120146764 18 0.9424928367218739 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate HSC_retention -0.006717441825022219 -0.006717542867094771 18 0.9818170425687693 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate TGFb_integrator -0.10166691545842428 -0.10201938586150518 18 0.7294672293492866 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate Endo_resolver 0.26009314981573706 0.2662083127463081 18 0.3691620459655829 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate LAM_resolver 0.2572385819778452 0.2631490532055095 18 0.37462786468183024 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late HSC_retention 0.22376712653969094 0.2276183095235465 18 0.4418756443426487 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late TGFb_integrator -0.4192300808943807 -0.44675756850227233 18 0.13566684703671386 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late Endo_resolver -0.5850418368357015 -0.6700941889731975 18 0.0279699726651109 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late LAM_resolver 0.1804328961216337 0.18243011627192093 18 0.5370535431721642 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late HSC_retention 0.7198095177166953 0.9072495762089993 18 0.003699558542468065 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late TGFb_integrator -0.007965756097766119 -0.007965924588605641 18 0.9784387296028475 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late Endo_resolver -0.49134564910111667 -0.537832700277003 18 0.07437640316071106 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late LAM_resolver -0.2852534578264596 -0.2933916139729258 18 0.32288162460965725 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late HSC_retention 0.09584111520099366 0.09613619332356954 18 0.7444835051487931 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late TGFb_integrator 0.2618170259581187 0.268058159529084 18 0.36588221593500553 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late Endo_resolver 0.3748185576416854 0.39401756396805354 18 0.18668420833596877 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late LAM_resolver 0.14876326474569768 0.14987547302054513 18 0.6117584274831447 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate HSC_retention 0.4474668704292536 0.48152846356306284 18 0.10863979508559782 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate TGFb_integrator 0.3087800913099334 0.31919636708430116 18 0.2827505299512241 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate Endo_resolver -0.13334461013420124 -0.13414347422077602 18 0.649503765706608 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate LAM_resolver -0.06219582138083074 -0.06227620581913451 18 0.8327144325166109 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early HSC_retention 0.2109468098453197 0.21416204343210854 18 0.4691203132362119 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early TGFb_integrator 0.021467057979311553 0.021470356478934197 18 0.94193261189281 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early Endo_resolver -0.15867128151370027 -0.16002336539232667 18 0.587960469765459 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early LAM_resolver 0.28625367918529065 0.2944807706547063 18 0.3211130702033568 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate HSC_retention -0.2306577462396187 -0.23488406228776443 18 0.42756544126134416 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate TGFb_integrator -0.16679712673706132 -0.16837030881350398 18 0.5687263993046259 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate Endo_resolver -0.3311193845265791 -0.3440849588689727 18 0.24750971798363933 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate LAM_resolver 0.13936803956564472 0.14028103965999297 18 0.6346588726945037 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late HSC_retention 0.004174360663760363 0.004174384910491335 18 0.9887002034074287 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late TGFb_integrator -0.15382657791909018 -0.155057413718774 18 0.5995505222120442 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late Endo_resolver -0.1482432259685807 -0.1493437070823939 18 0.6130176575230235 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late LAM_resolver 0.12042552135733454 0.12101278919434942 18 0.6817481192782963 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late HSC_retention -0.11978998036239057 -0.12036794574752395 18 0.6833479839410329 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late TGFb_integrator 0.31303946868865284 0.32391154699675484 18 0.2758149415002342 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late Endo_resolver -0.594943366133749 -0.6852833067126425 18 0.024813379927981178 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late LAM_resolver -0.2401528883796539 -0.2449363519781951 18 0.4082373364208849 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late HSC_retention 0.3560504581460627 0.37235565347696964 14 0.3125936482168487 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late TGFb_integrator -0.5743654995771974 -0.6540133074570377 14 0.08246583852556302 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late Endo_resolver 0.17903198455929925 0.18098243903759118 14 0.6206807482859863 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late LAM_resolver -0.3850067279267371 -0.40592447414503435 14 0.2719264124998046 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late HSC_retention -0.06434061775823287 -0.06442962287870448 18 0.8270236895799545 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late TGFb_integrator 0.35367102735303574 0.36963342032849505 18 0.21478282550240327 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late Endo_resolver 0.026748114298962906 0.026754496121806415 18 0.927678286508653 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late LAM_resolver -0.26000324426590016 -0.2661118863554593 18 0.3693335335646361 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early HSC_retention 0.2482932305426342 0.25359308401385827 18 0.3920345740316016 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early TGFb_integrator 0.1737621637595972 0.17554336210860674 18 0.5524515567292086 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early Endo_resolver -0.44610588061711876 -0.4798280374570472 18 0.10984993322487425 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early LAM_resolver 0.1766269780975956 0.17849889324820517 18 0.5458157299033604 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early HSC_retention -0.04831500890314019 -0.04835265620018245 18 0.8697171862026535 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early TGFb_integrator -0.48616876815099364 -0.5310309610515961 18 0.07795593679710291 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early Endo_resolver 0.10986568940486066 0.11031096216385414 18 0.7084873539045455 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early LAM_resolver 0.04564964143183207 0.04568139074535732 18 0.876853116899138 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late HSC_retention 0.23025771642006176 0.2344615948944717 18 0.42838973407283176 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late TGFb_integrator -0.45334094547965276 -0.48889748899066343 18 0.10352175290996712 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late Endo_resolver -0.013873969668980711 -0.01387485995822999 18 0.9624547765741729 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late LAM_resolver -0.14279829923090218 -0.14378096720617153 18 0.6262611697229403 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late HSC_retention 0.49040046439657714 0.536587468958982 18 0.07502108289288319 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late TGFb_integrator 0.8837719751841805 1.392738711387624 18 2.7583911516275718e-05 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late Endo_resolver 0.4938115202272057 0.541088555160558 18 0.0727130061849848 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late LAM_resolver 0.5010745081572082 0.5507398498774951 18 0.06796722877481584 diff --git a/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_cross_module_summary.tsv b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_cross_module_summary.tsv new file mode 100644 index 0000000..f1f6ee1 --- /dev/null +++ b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_cross_module_summary.tsv @@ -0,0 +1,5 @@ +target n_patients median mean positive_fraction bootstrap_median_ci_low bootstrap_median_ci_high wilcoxon_signed_rank_p wilcoxon_fdr +Endo_resolver 32 -0.10025948990789599 -0.14388836008447636 0.3125 -0.22983394557275974 -0.0061652192092056446 0.01323032844811678 0.02646065689623356 +HSC_retention 32 0.22513949042681689 0.21481333445082046 0.71875 0.07146620097099321 0.37638783948293036 0.00012157298624515533 0.00048629194498062134 +LAM_resolver 32 0.00796526833264978 -0.020690497470472507 0.5 -0.14279829923090218 0.09250884049873839 0.6779994335956872 0.6779994335956872 +TGFb_integrator 32 0.04947294418951652 0.059127133887147854 0.5625 -0.1263399772926685 0.16658537520640665 0.573302308563143 0.6779994335956872 diff --git a/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_gene_detection.tsv b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_gene_detection.tsv new file mode 100644 index 0000000..8c5c416 --- /dev/null +++ b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_gene_detection.tsv @@ -0,0 +1,452 @@ +scope unit array gene n_spots n_detected detection_fraction mean_log1p_cp10k +array VLP115_A VLP115_A SERPINE1 1743 128 0.07343660355708548 0.1149063830186287 +array VLP115_A VLP115_A SPON1 1743 26 0.01491681009753299 0.021429846309752653 +array VLP115_A VLP115_A ITGAV 1743 145 0.0831899024670109 0.12176702252514672 +array VLP115_A VLP115_A ITGB5 1743 387 0.22203098106712565 0.3448189205657535 +array VLP115_A VLP115_A MMP2 1743 114 0.06540447504302926 0.09792156523346357 +array VLP115_A VLP115_A MMP9 1743 43 0.024670109007458405 0.04074311219765666 +array VLP115_A VLP115_A MMP14 1743 114 0.06540447504302926 0.09814244479819338 +array VLP115_A VLP115_A PLAU 1743 35 0.020080321285140562 0.030161561214545527 +array VLP115_A VLP115_A PLAT 1743 58 0.03327596098680436 0.05044234466919236 +array VLP115_A VLP115_A TIMP1 1743 682 0.3912794033275961 0.7194803353800365 +array VLP115_A VLP115_A TIMP2 1743 390 0.22375215146299485 0.36620098229398906 +array VLP116_D VLP116_D SERPINE1 2173 485 0.223193741371376 0.23593190672472342 +array VLP116_D VLP116_D SPON1 2173 109 0.050161067648412334 0.05020241509936143 +array VLP116_D VLP116_D ITGAV 2173 593 0.27289461573861024 0.2936830295626162 +array VLP116_D VLP116_D ITGB5 2173 1065 0.490105844454671 0.5943764933553899 +array VLP116_D VLP116_D MMP2 2173 592 0.2724344224574321 0.3258031862150314 +array VLP116_D VLP116_D MMP9 2173 69 0.031753336401288544 0.030537347700747484 +array VLP116_D VLP116_D MMP14 2173 471 0.21675103543488264 0.22965571558938316 +array VLP116_D VLP116_D PLAU 2173 104 0.04786010124252186 0.04737411936828127 +array VLP116_D VLP116_D PLAT 2173 122 0.05614358030372756 0.06220044201406732 +array VLP116_D VLP116_D TIMP1 2173 1392 0.640589047399908 1.0841585373762346 +array VLP116_D VLP116_D TIMP2 2173 867 0.39898757478140817 0.4863514644443044 +array VLP119_A VLP119_A SERPINE1 1691 295 0.17445298639858073 0.19115071989405932 +array VLP119_A VLP119_A SPON1 1691 44 0.026020106445890007 0.02403182971991623 +array VLP119_A VLP119_A ITGAV 1691 278 0.16439976345357776 0.16937301125103138 +array VLP119_A VLP119_A ITGB5 1691 666 0.39384979302188056 0.43476853900410334 +array VLP119_A VLP119_A MMP2 1691 220 0.13010053222945003 0.13448476730620054 +array VLP119_A VLP119_A MMP9 1691 27 0.01596688350088705 0.016611469245232477 +array VLP119_A VLP119_A MMP14 1691 279 0.16499112950916617 0.16580882089102714 +array VLP119_A VLP119_A PLAU 1691 43 0.0254287403903016 0.02359479807747557 +array VLP119_A VLP119_A PLAT 1691 61 0.036073329390892965 0.03338914251678549 +array VLP119_A VLP119_A TIMP1 1691 928 0.5487876995860438 0.7434186184082228 +array VLP119_A VLP119_A TIMP2 1691 515 0.30455351862803076 0.3328649947906176 +array VLP119_D VLP119_D SERPINE1 1255 260 0.20717131474103587 0.2257673270082488 +array VLP119_D VLP119_D SPON1 1255 67 0.05338645418326693 0.057231549094341395 +array VLP119_D VLP119_D ITGAV 1255 246 0.19601593625498007 0.20609188159163103 +array VLP119_D VLP119_D ITGB5 1255 487 0.3880478087649402 0.4353859066836008 +array VLP119_D VLP119_D MMP2 1255 210 0.16733067729083664 0.2021850284236509 +array VLP119_D VLP119_D MMP9 1255 21 0.016733067729083666 0.021024229453953703 +array VLP119_D VLP119_D MMP14 1255 220 0.1752988047808765 0.1888290630023086 +array VLP119_D VLP119_D PLAU 1255 37 0.02948207171314741 0.02719658826658725 +array VLP119_D VLP119_D PLAT 1255 59 0.04701195219123506 0.04825378845189705 +array VLP119_D VLP119_D TIMP1 1255 693 0.552191235059761 0.7495637295925213 +array VLP119_D VLP119_D TIMP2 1255 390 0.3107569721115538 0.34972920872489605 +array VLP120_A VLP120_A SERPINE1 1884 735 0.39012738853503187 0.2998731934902987 +array VLP120_A VLP120_A SPON1 1884 89 0.04723991507430998 0.037116854303497544 +array VLP120_A VLP120_A ITGAV 1884 579 0.3073248407643312 0.22250904958240791 +array VLP120_A VLP120_A ITGB5 1884 1148 0.6093418259023354 0.5281345202110539 +array VLP120_A VLP120_A MMP2 1884 339 0.17993630573248406 0.16268320177910595 +array VLP120_A VLP120_A MMP9 1884 38 0.020169851380042462 0.01586286051598242 +array VLP120_A VLP120_A MMP14 1884 462 0.24522292993630573 0.17708081269253095 +array VLP120_A VLP120_A PLAU 1884 88 0.04670912951167728 0.032085954573293364 +array VLP120_A VLP120_A PLAT 1884 121 0.06422505307855626 0.04987275535915879 +array VLP120_A VLP120_A TIMP1 1884 1332 0.7070063694267515 0.789747542427114 +array VLP120_A VLP120_A TIMP2 1884 862 0.4575371549893843 0.3919318012303443 +array VLP120_D VLP120_D SERPINE1 1650 388 0.23515151515151514 0.24923579915801444 +array VLP120_D VLP120_D SPON1 1650 40 0.024242424242424242 0.02218834310504278 +array VLP120_D VLP120_D ITGAV 1650 357 0.21636363636363637 0.2121601408410166 +array VLP120_D VLP120_D ITGB5 1650 715 0.43333333333333335 0.45622551018036533 +array VLP120_D VLP120_D MMP2 1650 264 0.16 0.15457943751550507 +array VLP120_D VLP120_D MMP9 1650 32 0.019393939393939394 0.0179741620123138 +array VLP120_D VLP120_D MMP14 1650 319 0.19333333333333333 0.18051414276670308 +array VLP120_D VLP120_D PLAU 1650 58 0.03515151515151515 0.031503301955504846 +array VLP120_D VLP120_D PLAT 1650 44 0.02666666666666667 0.021635679434259675 +array VLP120_D VLP120_D TIMP1 1650 1050 0.6363636363636364 0.8840074672044986 +array VLP120_D VLP120_D TIMP2 1650 655 0.396969696969697 0.4310560542640623 +array VLP121_A VLP121_A SERPINE1 1506 232 0.15405046480743692 0.10375736415290024 +array VLP121_A VLP121_A SPON1 1506 137 0.09096945551128818 0.06675329587210828 +array VLP121_A VLP121_A ITGAV 1506 387 0.25697211155378485 0.1810269534752274 +array VLP121_A VLP121_A ITGB5 1506 722 0.47941567065073043 0.35450078743624425 +array VLP121_A VLP121_A MMP2 1506 488 0.3240371845949535 0.3000779511842761 +array VLP121_A VLP121_A MMP9 1506 59 0.039176626826029216 0.03198231513580521 +array VLP121_A VLP121_A MMP14 1506 489 0.3247011952191235 0.2497492500766816 +array VLP121_A VLP121_A PLAU 1506 87 0.05776892430278884 0.03809072677254733 +array VLP121_A VLP121_A PLAT 1506 142 0.09428950863213811 0.06812745355688332 +array VLP121_A VLP121_A TIMP1 1506 1215 0.8067729083665338 1.0343243335110905 +array VLP121_A VLP121_A TIMP2 1506 542 0.3598937583001328 0.2803117908030413 +array VLP121_D VLP121_D SERPINE1 1683 281 0.16696375519904932 0.17286798641610304 +array VLP121_D VLP121_D SPON1 1683 52 0.030897207367795602 0.03153113854571911 +array VLP121_D VLP121_D ITGAV 1683 197 0.11705288175876412 0.12148830230959813 +array VLP121_D VLP121_D ITGB5 1683 400 0.23767082590612001 0.2517530996944408 +array VLP121_D VLP121_D MMP2 1683 307 0.18241235888294713 0.20298170404453697 +array VLP121_D VLP121_D MMP9 1683 9 0.0053475935828877 0.005773239095638656 +array VLP121_D VLP121_D MMP14 1683 337 0.20023767082590613 0.2163174981706887 +array VLP121_D VLP121_D PLAU 1683 53 0.0314913844325609 0.032433377053996855 +array VLP121_D VLP121_D PLAT 1683 50 0.029708853238265002 0.027398065542256607 +array VLP121_D VLP121_D TIMP1 1683 978 0.5811051693404634 0.8597444054699742 +array VLP121_D VLP121_D TIMP2 1683 320 0.19013666072489602 0.20845338289478751 +biopsy UQ_B01 VLP115_A SERPINE1 351 16 0.045584045584045586 0.06825746400320913 +biopsy UQ_B01 VLP115_A SPON1 351 13 0.037037037037037035 0.04754113594278424 +biopsy UQ_B01 VLP115_A ITGAV 351 53 0.150997150997151 0.20339084424392703 +biopsy UQ_B01 VLP115_A ITGB5 351 99 0.28205128205128205 0.4153358800996928 +biopsy UQ_B01 VLP115_A MMP2 351 41 0.1168091168091168 0.1509120562040684 +biopsy UQ_B01 VLP115_A MMP9 351 11 0.03133903133903134 0.043509670820398874 +biopsy UQ_B01 VLP115_A MMP14 351 39 0.1111111111111111 0.1469369188473536 +biopsy UQ_B01 VLP115_A PLAU 351 11 0.03133903133903134 0.038606854055113174 +biopsy UQ_B01 VLP115_A PLAT 351 21 0.05982905982905983 0.07904322143073336 +biopsy UQ_B01 VLP115_A TIMP1 351 227 0.6467236467236467 1.1485798735885093 +biopsy UQ_B01 VLP115_A TIMP2 351 120 0.3418803418803419 0.5188096460595251 +biopsy UQ_B02 VLP115_A SERPINE1 709 36 0.05077574047954866 0.09283926336393367 +biopsy UQ_B02 VLP115_A SPON1 709 6 0.00846262341325811 0.013489734456866178 +biopsy UQ_B02 VLP115_A ITGAV 709 40 0.056417489421720736 0.09617856558838177 +biopsy UQ_B02 VLP115_A ITGB5 709 125 0.1763046544428773 0.30146393008483535 +biopsy UQ_B02 VLP115_A MMP2 709 21 0.029619181946403384 0.051463184962259594 +biopsy UQ_B02 VLP115_A MMP9 709 20 0.028208744710860368 0.05147109436853312 +biopsy UQ_B02 VLP115_A MMP14 709 35 0.04936530324400564 0.08902915130492506 +biopsy UQ_B02 VLP115_A PLAU 709 9 0.012693935119887164 0.021612297082519927 +biopsy UQ_B02 VLP115_A PLAT 709 14 0.019746121297602257 0.03549125899785383 +biopsy UQ_B02 VLP115_A TIMP1 709 229 0.3229901269393512 0.6484283564243506 +biopsy UQ_B02 VLP115_A TIMP2 709 123 0.17348377997179126 0.3084569563041812 +biopsy UQ_B03 VLP115_A SERPINE1 260 16 0.06153846153846154 0.11633091269628149 +biopsy UQ_B03 VLP115_A SPON1 260 1 0.0038461538461538464 0.0054015937879584195 +biopsy UQ_B03 VLP115_A ITGAV 260 18 0.06923076923076923 0.11890654443750752 +biopsy UQ_B03 VLP115_A ITGB5 260 46 0.17692307692307693 0.3123200402850153 +biopsy UQ_B03 VLP115_A MMP2 260 21 0.08076923076923077 0.14045085706077048 +biopsy UQ_B03 VLP115_A MMP9 260 8 0.03076923076923077 0.05366944185428991 +biopsy UQ_B03 VLP115_A MMP14 260 15 0.057692307692307696 0.09448185772517605 +biopsy UQ_B03 VLP115_A PLAU 260 7 0.026923076923076925 0.047278986931440455 +biopsy UQ_B03 VLP115_A PLAT 260 7 0.026923076923076925 0.05058135010238571 +biopsy UQ_B03 VLP115_A TIMP1 260 90 0.34615384615384615 0.7120560551460732 +biopsy UQ_B03 VLP115_A TIMP2 260 65 0.25 0.4582233164742772 +biopsy UQ_B04 VLP115_A SERPINE1 423 60 0.14184397163120568 0.18972666834581864 +biopsy UQ_B04 VLP115_A SPON1 423 6 0.014184397163120567 0.022923516045376582 +biopsy UQ_B04 VLP115_A ITGAV 423 34 0.08037825059101655 0.09868423020283149 +biopsy UQ_B04 VLP115_A ITGB5 423 117 0.2765957446808511 0.378948812593059 +biopsy UQ_B04 VLP115_A MMP2 423 31 0.07328605200945626 0.10567975295568943 +biopsy UQ_B04 VLP115_A MMP9 423 4 0.009456264775413711 0.012520778518085576 +biopsy UQ_B04 VLP115_A MMP14 423 25 0.0591016548463357 0.07517841958414254 +biopsy UQ_B04 VLP115_A PLAU 423 8 0.018912529550827423 0.026962033545926654 +biopsy UQ_B04 VLP115_A PLAT 423 16 0.037825059101654845 0.051684119101929625 +biopsy UQ_B04 VLP115_A TIMP1 423 136 0.3215130023640662 0.48707425507090674 +biopsy UQ_B04 VLP115_A TIMP2 423 82 0.1938534278959811 0.2797921561904329 +biopsy UQ_B05 VLP116_D SERPINE1 514 106 0.20622568093385213 0.18957210696469465 +biopsy UQ_B05 VLP116_D SPON1 514 42 0.08171206225680934 0.08600173640056163 +biopsy UQ_B05 VLP116_D ITGAV 514 167 0.32490272373540857 0.3223959172899972 +biopsy UQ_B05 VLP116_D ITGB5 514 295 0.5739299610894941 0.6359296938971775 +biopsy UQ_B05 VLP116_D MMP2 514 217 0.42217898832684825 0.5213587438633001 +biopsy UQ_B05 VLP116_D MMP9 514 35 0.06809338521400778 0.05930369765226572 +biopsy UQ_B05 VLP116_D MMP14 514 159 0.3093385214007782 0.31090133928620856 +biopsy UQ_B05 VLP116_D PLAU 514 41 0.07976653696498054 0.07142497024586321 +biopsy UQ_B05 VLP116_D PLAT 514 47 0.0914396887159533 0.09484466733887771 +biopsy UQ_B05 VLP116_D TIMP1 514 417 0.811284046692607 1.2303424229529216 +biopsy UQ_B05 VLP116_D TIMP2 514 271 0.5272373540856031 0.6108241816273832 +biopsy UQ_B06 VLP116_D SERPINE1 197 72 0.36548223350253806 0.2982538692333747 +biopsy UQ_B06 VLP116_D SPON1 197 11 0.05583756345177665 0.04508080145995003 +biopsy UQ_B06 VLP116_D ITGAV 197 64 0.3248730964467005 0.25287175098820985 +biopsy UQ_B06 VLP116_D ITGB5 197 117 0.5939086294416244 0.5635377510365758 +biopsy UQ_B06 VLP116_D MMP2 197 54 0.27411167512690354 0.25468802535611235 +biopsy UQ_B06 VLP116_D MMP9 197 7 0.03553299492385787 0.037951845015884965 +biopsy UQ_B06 VLP116_D MMP14 197 42 0.2131979695431472 0.17275487702786568 +biopsy UQ_B06 VLP116_D PLAU 197 4 0.02030456852791878 0.0157265848634835 +biopsy UQ_B06 VLP116_D PLAT 197 1 0.005076142131979695 0.004073169457293165 +biopsy UQ_B06 VLP116_D TIMP1 197 144 0.7309644670050761 0.9171184987153953 +biopsy UQ_B06 VLP116_D TIMP2 197 70 0.3553299492385787 0.3047306753405961 +biopsy UQ_B07 VLP116_D SERPINE1 838 233 0.27804295942720764 0.2955889354720433 +biopsy UQ_B07 VLP116_D SPON1 838 52 0.06205250596658711 0.0601913997838826 +biopsy UQ_B07 VLP116_D ITGAV 838 307 0.36634844868735084 0.40395776697199365 +biopsy UQ_B07 VLP116_D ITGB5 838 481 0.5739856801909308 0.6953850026577302 +biopsy UQ_B07 VLP116_D MMP2 838 281 0.3353221957040573 0.38944027505020395 +biopsy UQ_B07 VLP116_D MMP9 838 25 0.029832935560859187 0.03035934295213051 +biopsy UQ_B07 VLP116_D MMP14 838 228 0.2720763723150358 0.2902825091979008 +biopsy UQ_B07 VLP116_D PLAU 838 54 0.06443914081145585 0.06344992049321355 +biopsy UQ_B07 VLP116_D PLAT 838 62 0.07398568019093078 0.07331440035909212 +biopsy UQ_B07 VLP116_D TIMP1 838 652 0.7780429594272077 1.4973726435377948 +biopsy UQ_B07 VLP116_D TIMP2 838 402 0.4797136038186158 0.5745234206989577 +biopsy UQ_B08 VLP116_D SERPINE1 624 74 0.11858974358974358 0.17432761244939707 +biopsy UQ_B08 VLP116_D SPON1 624 4 0.00641025641025641 0.00891609710660251 +biopsy UQ_B08 VLP116_D ITGAV 624 55 0.08814102564102565 0.1348227212905421 +biopsy UQ_B08 VLP116_D ITGB5 624 172 0.27564102564102566 0.43423507727040034 +biopsy UQ_B08 VLP116_D MMP2 624 40 0.0641025641025641 0.10171063751971453 +biopsy UQ_B08 VLP116_D MMP9 624 2 0.003205128205128205 0.004740245350072105 +biopsy UQ_B08 VLP116_D MMP14 624 42 0.0673076923076923 0.09927744887866685 +biopsy UQ_B08 VLP116_D PLAU 624 5 0.008012820512820512 0.01596531424596522 +biopsy UQ_B08 VLP116_D PLAT 624 12 0.019230769230769232 0.03873640961599229 +biopsy UQ_B08 VLP116_D TIMP1 624 179 0.28685897435897434 0.4615542897262044 +biopsy UQ_B08 VLP116_D TIMP2 624 124 0.1987179487179487 0.32274925207239485 +biopsy UQ_B09 VLP119_A SERPINE1 232 78 0.33620689655172414 0.39531905603252804 +biopsy UQ_B09 VLP119_A SPON1 232 1 0.004310344827586207 0.0026850344465236434 +biopsy UQ_B09 VLP119_A ITGAV 232 27 0.11637931034482758 0.11123317897906396 +biopsy UQ_B09 VLP119_A ITGB5 232 102 0.4396551724137931 0.4800036033063847 +biopsy UQ_B09 VLP119_A MMP2 232 12 0.05172413793103448 0.042953325573635674 +biopsy UQ_B09 VLP119_A MMP9 232 1 0.004310344827586207 0.0038823659838184837 +biopsy UQ_B09 VLP119_A MMP14 232 22 0.09482758620689655 0.09004924296728237 +biopsy UQ_B09 VLP119_A PLAU 232 7 0.03017241379310345 0.024960748571788413 +biopsy UQ_B09 VLP119_A PLAT 232 8 0.034482758620689655 0.0333718752626491 +biopsy UQ_B09 VLP119_A TIMP1 232 101 0.4353448275862069 0.5408493631775722 +biopsy UQ_B09 VLP119_A TIMP2 232 55 0.23706896551724138 0.24250964982904363 +biopsy UQ_B10 VLP119_A SERPINE1 444 81 0.18243243243243243 0.2051222466148047 +biopsy UQ_B10 VLP119_A SPON1 444 18 0.04054054054054054 0.04238265121816162 +biopsy UQ_B10 VLP119_A ITGAV 444 105 0.23648648648648649 0.2644972336448867 +biopsy UQ_B10 VLP119_A ITGB5 444 200 0.45045045045045046 0.5349524681168055 +biopsy UQ_B10 VLP119_A MMP2 444 122 0.2747747747747748 0.30981558598970665 +biopsy UQ_B10 VLP119_A MMP9 444 7 0.015765765765765764 0.015634692839575536 +biopsy UQ_B10 VLP119_A MMP14 444 104 0.23423423423423423 0.25759658167831273 +biopsy UQ_B10 VLP119_A PLAU 444 19 0.04279279279279279 0.042918629432062615 +biopsy UQ_B10 VLP119_A PLAT 444 12 0.02702702702702703 0.028123198476667374 +biopsy UQ_B10 VLP119_A TIMP1 444 329 0.740990990990991 1.2023942170588153 +biopsy UQ_B10 VLP119_A TIMP2 444 166 0.3738738738738739 0.44345741809361017 +biopsy UQ_B11 VLP119_A SERPINE1 384 52 0.13541666666666666 0.11299318442733912 +biopsy UQ_B11 VLP119_A SPON1 384 19 0.049479166666666664 0.039276123492654004 +biopsy UQ_B11 VLP119_A ITGAV 384 73 0.19010416666666666 0.16534023298494208 +biopsy UQ_B11 VLP119_A ITGB5 384 190 0.4947916666666667 0.47544406964790015 +biopsy UQ_B11 VLP119_A MMP2 384 59 0.15364583333333334 0.1297134285808922 +biopsy UQ_B11 VLP119_A MMP9 384 15 0.0390625 0.040511150691100006 +biopsy UQ_B11 VLP119_A MMP14 384 76 0.19791666666666666 0.16205257462050257 +biopsy UQ_B11 VLP119_A PLAU 384 9 0.0234375 0.016320755176546433 +biopsy UQ_B11 VLP119_A PLAT 384 22 0.057291666666666664 0.04773676990291842 +biopsy UQ_B11 VLP119_A TIMP1 384 258 0.671875 0.7809511313702237 +biopsy UQ_B11 VLP119_A TIMP2 384 149 0.3880208333333333 0.37531199941215015 +biopsy UQ_B12 VLP119_A SERPINE1 631 84 0.13312202852614896 0.15381645962636503 +biopsy UQ_B12 VLP119_A SPON1 631 6 0.009508716323296355 0.009690915218291537 +biopsy UQ_B12 VLP119_A ITGAV 631 73 0.11568938193343899 0.1262697992041264 +biopsy UQ_B12 VLP119_A ITGB5 631 174 0.2757527733755943 0.3228896115692585 +biopsy UQ_B12 VLP119_A MMP2 631 27 0.042789223454833596 0.047671146160395056 +biopsy UQ_B12 VLP119_A MMP9 631 4 0.006339144215530904 0.007434548493325348 +biopsy UQ_B12 VLP119_A MMP14 631 77 0.12202852614896989 0.1313632659887061 +biopsy UQ_B12 VLP119_A PLAU 631 8 0.012678288431061807 0.013922136964701504 +biopsy UQ_B12 VLP119_A PLAT 631 19 0.030110935023771792 0.028369485211709494 +biopsy UQ_B12 VLP119_A TIMP1 631 240 0.3803486529318542 0.4721007363721523 +biopsy UQ_B12 VLP119_A TIMP2 631 145 0.22979397781299524 0.2624367131898061 +biopsy UQ_B13 VLP119_D SERPINE1 190 23 0.12105263157894737 0.09202787153546006 +biopsy UQ_B13 VLP119_D SPON1 190 55 0.2894736842105263 0.3159828429006579 +biopsy UQ_B13 VLP119_D ITGAV 190 70 0.3684210526315789 0.37479796303107527 +biopsy UQ_B13 VLP119_D ITGB5 190 123 0.6473684210526316 0.7109289164310546 +biopsy UQ_B13 VLP119_D MMP2 190 103 0.5421052631578948 0.7622078740666243 +biopsy UQ_B13 VLP119_D MMP9 190 12 0.06315789473684211 0.08703314027902331 +biopsy UQ_B13 VLP119_D MMP14 190 71 0.3736842105263158 0.42094152549182245 +biopsy UQ_B13 VLP119_D PLAU 190 13 0.06842105263157895 0.061236031519268076 +biopsy UQ_B13 VLP119_D PLAT 190 34 0.17894736842105263 0.19665105125371318 +biopsy UQ_B13 VLP119_D TIMP1 190 151 0.7947368421052632 1.174499771002345 +biopsy UQ_B13 VLP119_D TIMP2 190 116 0.6105263157894737 0.7522087554260676 +biopsy UQ_B14 VLP119_D SERPINE1 394 85 0.21573604060913706 0.24153692287338369 +biopsy UQ_B14 VLP119_D SPON1 394 3 0.007614213197969543 0.007100913652749427 +biopsy UQ_B14 VLP119_D ITGAV 394 46 0.116751269035533 0.12648411300626344 +biopsy UQ_B14 VLP119_D ITGB5 394 132 0.3350253807106599 0.3774977247374089 +biopsy UQ_B14 VLP119_D MMP2 394 30 0.07614213197969544 0.07129441951629709 +biopsy UQ_B14 VLP119_D MMP9 394 1 0.0025380710659898475 0.0014588607125091396 +biopsy UQ_B14 VLP119_D MMP14 394 41 0.10406091370558376 0.10475723443005394 +biopsy UQ_B14 VLP119_D PLAU 394 5 0.012690355329949238 0.013377111198214931 +biopsy UQ_B14 VLP119_D PLAT 394 10 0.025380710659898477 0.02414592582817366 +biopsy UQ_B14 VLP119_D TIMP1 394 188 0.47715736040609136 0.5927346614818048 +biopsy UQ_B14 VLP119_D TIMP2 394 85 0.21573604060913706 0.22358985565519596 +biopsy UQ_B15 VLP119_D SERPINE1 163 38 0.2331288343558282 0.21623812792179087 +biopsy UQ_B15 VLP119_D SPON1 163 2 0.012269938650306749 0.007782062089454506 +biopsy UQ_B15 VLP119_D ITGAV 163 25 0.15337423312883436 0.130815555975698 +biopsy UQ_B15 VLP119_D ITGB5 163 52 0.31901840490797545 0.26374770187268454 +biopsy UQ_B15 VLP119_D MMP2 163 11 0.06748466257668712 0.05145583125475968 +biopsy UQ_B15 VLP119_D MMP9 163 0 0.0 0.0 +biopsy UQ_B15 VLP119_D MMP14 163 19 0.1165644171779141 0.09847982579186222 +biopsy UQ_B15 VLP119_D PLAU 163 7 0.04294478527607362 0.03144280657590768 +biopsy UQ_B15 VLP119_D PLAT 163 5 0.03067484662576687 0.02221614897378546 +biopsy UQ_B15 VLP119_D TIMP1 163 82 0.5030674846625767 0.48195685059189697 +biopsy UQ_B15 VLP119_D TIMP2 163 38 0.2331288343558282 0.20459365715584207 +biopsy UQ_B16 VLP119_D SERPINE1 508 114 0.22440944881889763 0.2666148372839562 +biopsy UQ_B16 VLP119_D SPON1 508 7 0.013779527559055118 0.0152020036663565 +biopsy UQ_B16 VLP119_D ITGAV 508 105 0.20669291338582677 0.2288898076241852 +biopsy UQ_B16 VLP119_D ITGB5 508 180 0.3543307086614173 0.4322988972721102 +biopsy UQ_B16 VLP119_D MMP2 508 66 0.12992125984251968 0.14260908034463862 +biopsy UQ_B16 VLP119_D MMP9 508 8 0.015748031496062992 0.018256535808993828 +biopsy UQ_B16 VLP119_D MMP14 508 89 0.17519685039370078 0.19621067373018944 +biopsy UQ_B16 VLP119_D PLAU 508 12 0.023622047244094488 0.023821088586489035 +biopsy UQ_B16 VLP119_D PLAT 508 10 0.01968503937007874 0.01980330257853907 +biopsy UQ_B16 VLP119_D TIMP1 508 272 0.5354330708661418 0.7981320883422408 +biopsy UQ_B16 VLP119_D TIMP2 508 151 0.297244094488189 0.34359709483118556 +biopsy UQ_B17 VLP120_A SERPINE1 306 178 0.5816993464052288 0.4937000083139499 +biopsy UQ_B17 VLP120_A SPON1 306 0 0.0 0.0 +biopsy UQ_B17 VLP120_A ITGAV 306 87 0.28431372549019607 0.17805057104939065 +biopsy UQ_B17 VLP120_A ITGB5 306 189 0.6176470588235294 0.49696051698116056 +biopsy UQ_B17 VLP120_A MMP2 306 20 0.06535947712418301 0.04124679154101618 +biopsy UQ_B17 VLP120_A MMP9 306 4 0.013071895424836602 0.006459057183046582 +biopsy UQ_B17 VLP120_A MMP14 306 71 0.23202614379084968 0.15213705386976775 +biopsy UQ_B17 VLP120_A PLAU 306 8 0.026143790849673203 0.013789007448668929 +biopsy UQ_B17 VLP120_A PLAT 306 5 0.016339869281045753 0.009664262226132836 +biopsy UQ_B17 VLP120_A TIMP1 306 221 0.7222222222222222 0.657072934656799 +biopsy UQ_B17 VLP120_A TIMP2 306 127 0.4150326797385621 0.29707026286059396 +biopsy UQ_B18 VLP120_A SERPINE1 421 250 0.5938242280285035 0.4070171672411771 +biopsy UQ_B18 VLP120_A SPON1 421 7 0.0166270783847981 0.009481121109974252 +biopsy UQ_B18 VLP120_A ITGAV 421 147 0.3491686460807601 0.1959379950379281 +biopsy UQ_B18 VLP120_A ITGB5 421 303 0.7197149643705463 0.5285464189361481 +biopsy UQ_B18 VLP120_A MMP2 421 43 0.1021377672209026 0.056993427434652306 +biopsy UQ_B18 VLP120_A MMP9 421 11 0.026128266033254157 0.017320432738971252 +biopsy UQ_B18 VLP120_A MMP14 421 109 0.2589073634204275 0.14085534055772933 +biopsy UQ_B18 VLP120_A PLAU 421 13 0.030878859857482184 0.013876204496089709 +biopsy UQ_B18 VLP120_A PLAT 421 23 0.05463182897862233 0.024759055818097234 +biopsy UQ_B18 VLP120_A TIMP1 421 334 0.7933491686460807 0.705703000194868 +biopsy UQ_B18 VLP120_A TIMP2 421 201 0.47743467933491684 0.3094641902991365 +biopsy UQ_B19 VLP120_A SERPINE1 575 173 0.3008695652173913 0.21515665063375616 +biopsy UQ_B19 VLP120_A SPON1 575 33 0.057391304347826085 0.03998842080242798 +biopsy UQ_B19 VLP120_A ITGAV 575 176 0.3060869565217391 0.22064770599619643 +biopsy UQ_B19 VLP120_A ITGB5 575 337 0.5860869565217391 0.4881228046811133 +biopsy UQ_B19 VLP120_A MMP2 575 115 0.2 0.15409494077834923 +biopsy UQ_B19 VLP120_A MMP9 575 15 0.02608695652173913 0.025489189485659005 +biopsy UQ_B19 VLP120_A MMP14 575 143 0.24869565217391304 0.16969348529284556 +biopsy UQ_B19 VLP120_A PLAU 575 28 0.04869565217391304 0.03002831367190958 +biopsy UQ_B19 VLP120_A PLAT 575 24 0.04173913043478261 0.028966321979881467 +biopsy UQ_B19 VLP120_A TIMP1 575 414 0.72 0.7631432640606235 +biopsy UQ_B19 VLP120_A TIMP2 575 275 0.4782608695652174 0.37804401668571475 +biopsy UQ_B20 VLP120_A SERPINE1 582 134 0.23024054982817868 0.20415737537578824 +biopsy UQ_B20 VLP120_A SPON1 582 49 0.08419243986254296 0.07378566934552254 +biopsy UQ_B20 VLP120_A ITGAV 582 169 0.29037800687285226 0.26694372476522743 +biopsy UQ_B20 VLP120_A ITGB5 582 319 0.5481099656357389 0.5837574962502264 +biopsy UQ_B20 VLP120_A MMP2 582 161 0.2766323024054983 0.3114687457779128 +biopsy UQ_B20 VLP120_A MMP9 582 8 0.013745704467353952 0.010242219204016835 +biopsy UQ_B20 VLP120_A MMP14 582 139 0.23883161512027493 0.22369838524121854 +biopsy UQ_B20 VLP120_A PLAU 582 39 0.06701030927835051 0.05691123656802444 +biopsy UQ_B20 VLP120_A PLAT 582 69 0.11855670103092783 0.10983472374159405 +biopsy UQ_B20 VLP120_A TIMP1 582 363 0.6237113402061856 0.9465836976130656 +biopsy UQ_B20 VLP120_A TIMP2 582 259 0.44501718213058417 0.5151826106055061 +biopsy UQ_B21 VLP120_D SERPINE1 83 24 0.2891566265060241 0.45729076498153554 +biopsy UQ_B21 VLP120_D SPON1 83 0 0.0 0.0 +biopsy UQ_B21 VLP120_D ITGAV 83 11 0.13253012048192772 0.19487617750506703 +biopsy UQ_B21 VLP120_D ITGB5 83 18 0.21686746987951808 0.3039267733739768 +biopsy UQ_B21 VLP120_D MMP2 83 3 0.03614457831325301 0.06528862251919147 +biopsy UQ_B21 VLP120_D MMP9 83 0 0.0 0.0 +biopsy UQ_B21 VLP120_D MMP14 83 10 0.12048192771084337 0.16264738120588845 +biopsy UQ_B21 VLP120_D PLAU 83 1 0.012048192771084338 0.008897491212664836 +biopsy UQ_B21 VLP120_D PLAT 83 0 0.0 0.0 +biopsy UQ_B21 VLP120_D TIMP1 83 41 0.4939759036144578 0.782796715075886 +biopsy UQ_B21 VLP120_D TIMP2 83 26 0.3132530120481928 0.4405009159434992 +biopsy UQ_B22 VLP120_D SERPINE1 339 181 0.5339233038348082 0.5794511191501847 +biopsy UQ_B22 VLP120_D SPON1 339 13 0.038348082595870206 0.03439090016162154 +biopsy UQ_B22 VLP120_D ITGAV 339 94 0.27728613569321536 0.25220941952049075 +biopsy UQ_B22 VLP120_D ITGB5 339 192 0.5663716814159292 0.5443270801341346 +biopsy UQ_B22 VLP120_D MMP2 339 59 0.17404129793510326 0.15260410472814362 +biopsy UQ_B22 VLP120_D MMP9 339 12 0.035398230088495575 0.03319143484982989 +biopsy UQ_B22 VLP120_D MMP14 339 84 0.24778761061946902 0.22041156810436704 +biopsy UQ_B22 VLP120_D PLAU 339 11 0.032448377581120944 0.024891639906424106 +biopsy UQ_B22 VLP120_D PLAT 339 13 0.038348082595870206 0.027178871286784836 +biopsy UQ_B22 VLP120_D TIMP1 339 253 0.7463126843657817 1.02888630187071 +biopsy UQ_B22 VLP120_D TIMP2 339 152 0.44837758112094395 0.4404199254429974 +biopsy UQ_B23 VLP120_D SERPINE1 620 139 0.22419354838709676 0.18726843089826375 +biopsy UQ_B23 VLP120_D SPON1 620 17 0.027419354838709678 0.021266401798552628 +biopsy UQ_B23 VLP120_D ITGAV 620 189 0.30483870967741933 0.26595839454310805 +biopsy UQ_B23 VLP120_D ITGB5 620 343 0.5532258064516129 0.5148508557364685 +biopsy UQ_B23 VLP120_D MMP2 620 160 0.25806451612903225 0.23150869274367014 +biopsy UQ_B23 VLP120_D MMP9 620 14 0.02258064516129032 0.01692588330287867 +biopsy UQ_B23 VLP120_D MMP14 620 184 0.2967741935483871 0.24864853650941765 +biopsy UQ_B23 VLP120_D PLAU 620 35 0.056451612903225805 0.043071465548436334 +biopsy UQ_B23 VLP120_D PLAT 620 17 0.027419354838709678 0.019605340433543797 +biopsy UQ_B23 VLP120_D TIMP1 620 483 0.7790322580645161 0.9884833912535911 +biopsy UQ_B23 VLP120_D TIMP2 620 333 0.5370967741935484 0.5219063275730113 +biopsy UQ_B24 VLP120_D SERPINE1 608 44 0.07236842105263158 0.09990720159279645 +biopsy UQ_B24 VLP120_D SPON1 608 10 0.01644736842105263 0.019353753048401746 +biopsy UQ_B24 VLP120_D ITGAV 608 63 0.10361842105263158 0.13732946023122272 +biopsy UQ_B24 VLP120_D ITGB5 608 162 0.26644736842105265 0.36811144553533015 +biopsy UQ_B24 VLP120_D MMP2 608 42 0.06907894736842106 0.08942259083482615 +biopsy UQ_B24 VLP120_D MMP9 608 6 0.009868421052631578 0.013012209306645824 +biopsy UQ_B24 VLP120_D MMP14 608 41 0.06743421052631579 0.09122859983840784 +biopsy UQ_B24 VLP120_D PLAU 608 11 0.018092105263157895 0.02647924652569656 +biopsy UQ_B24 VLP120_D PLAT 608 14 0.023026315789473683 0.023568951696564554 +biopsy UQ_B24 VLP120_D TIMP1 608 273 0.44901315789473684 0.7105066358959323 +biopsy UQ_B24 VLP120_D TIMP2 608 144 0.23684210526315788 0.33190236133544293 +biopsy UQ_B25 VLP121_A SERPINE1 334 17 0.05089820359281437 0.04145807901200085 +biopsy UQ_B25 VLP121_A SPON1 334 10 0.029940119760479042 0.02480603852883233 +biopsy UQ_B25 VLP121_A ITGAV 334 53 0.15868263473053892 0.11926923598672716 +biopsy UQ_B25 VLP121_A ITGB5 334 104 0.31137724550898205 0.24891501662700558 +biopsy UQ_B25 VLP121_A MMP2 334 55 0.16467065868263472 0.1428817452079617 +biopsy UQ_B25 VLP121_A MMP9 334 3 0.008982035928143712 0.004928412739427066 +biopsy UQ_B25 VLP121_A MMP14 334 49 0.1467065868263473 0.11190290530040276 +biopsy UQ_B25 VLP121_A PLAU 334 4 0.011976047904191617 0.010289051071686246 +biopsy UQ_B25 VLP121_A PLAT 334 18 0.05389221556886228 0.03852165487634766 +biopsy UQ_B25 VLP121_A TIMP1 334 221 0.6616766467065869 0.6477993050924375 +biopsy UQ_B25 VLP121_A TIMP2 334 76 0.2275449101796407 0.1739188832651489 +biopsy UQ_B26 VLP121_A SERPINE1 465 86 0.18494623655913978 0.13794384208075525 +biopsy UQ_B26 VLP121_A SPON1 465 65 0.13978494623655913 0.09340757002927495 +biopsy UQ_B26 VLP121_A ITGAV 465 140 0.3010752688172043 0.22860984133735684 +biopsy UQ_B26 VLP121_A ITGB5 465 247 0.5311827956989247 0.409642484583738 +biopsy UQ_B26 VLP121_A MMP2 465 198 0.4258064516129032 0.39299266833585283 +biopsy UQ_B26 VLP121_A MMP9 465 33 0.07096774193548387 0.06387307202415679 +biopsy UQ_B26 VLP121_A MMP14 465 184 0.3956989247311828 0.30314405858548343 +biopsy UQ_B26 VLP121_A PLAU 465 38 0.08172043010752689 0.05286601325223375 +biopsy UQ_B26 VLP121_A PLAT 465 46 0.0989247311827957 0.06864902607434632 +biopsy UQ_B26 VLP121_A TIMP1 465 405 0.8709677419354839 1.3765733989248625 +biopsy UQ_B26 VLP121_A TIMP2 465 177 0.38064516129032255 0.3151755400515082 +biopsy UQ_B27 VLP121_A SERPINE1 590 85 0.1440677966101695 0.08822983710298274 +biopsy UQ_B27 VLP121_A SPON1 590 49 0.08305084745762711 0.06408396380911356 +biopsy UQ_B27 VLP121_A ITGAV 590 149 0.25254237288135595 0.1709059964346747 +biopsy UQ_B27 VLP121_A ITGB5 590 302 0.511864406779661 0.37231180169426037 +biopsy UQ_B27 VLP121_A MMP2 590 185 0.3135593220338983 0.3039915103140702 +biopsy UQ_B27 VLP121_A MMP9 590 15 0.025423728813559324 0.01936001697967846 +biopsy UQ_B27 VLP121_A MMP14 590 213 0.3610169491525424 0.28809702520589997 +biopsy UQ_B27 VLP121_A PLAU 590 38 0.06440677966101695 0.042559554637271076 +biopsy UQ_B27 VLP121_A PLAT 590 69 0.11694915254237288 0.08878386365063796 +biopsy UQ_B27 VLP121_A TIMP1 590 482 0.8169491525423729 0.944369847217512 +biopsy UQ_B27 VLP121_A TIMP2 590 231 0.39152542372881355 0.2941522905076127 +biopsy UQ_B28 VLP121_A SERPINE1 117 44 0.37606837606837606 0.2240350561192176 +biopsy UQ_B28 VLP121_A SPON1 117 13 0.1111111111111111 0.09402724789551475 +biopsy UQ_B28 VLP121_A ITGAV 117 45 0.38461538461538464 0.21925258970766306 +biopsy UQ_B28 VLP121_A ITGB5 117 69 0.5897435897435898 0.3469474529445489 +biopsy UQ_B28 VLP121_A MMP2 117 50 0.42735042735042733 0.3598146130135689 +biopsy UQ_B28 VLP121_A MMP9 117 8 0.06837606837606838 0.04611870282316929 +biopsy UQ_B28 VLP121_A MMP14 117 43 0.36752136752136755 0.2376715224907457 +biopsy UQ_B28 VLP121_A PLAU 117 7 0.05982905982905983 0.03619878686525161 +biopsy UQ_B28 VLP121_A PLAT 117 9 0.07692307692307693 0.04640543290186943 +biopsy UQ_B28 VLP121_A TIMP1 117 107 0.9145299145299145 1.2311336581917505 +biopsy UQ_B28 VLP121_A TIMP2 117 58 0.49572649572649574 0.37567668731091974 +biopsy UQ_B29 VLP121_D SERPINE1 361 23 0.06371191135734072 0.08188531176095801 +biopsy UQ_B29 VLP121_D SPON1 361 2 0.00554016620498615 0.005792662207099983 +biopsy UQ_B29 VLP121_D ITGAV 361 39 0.10803324099722991 0.14537879209026655 +biopsy UQ_B29 VLP121_D ITGB5 361 64 0.1772853185595568 0.24198349300847466 +biopsy UQ_B29 VLP121_D MMP2 361 52 0.1440443213296399 0.20238676910076758 +biopsy UQ_B29 VLP121_D MMP9 361 3 0.008310249307479225 0.010123253494544964 +biopsy UQ_B29 VLP121_D MMP14 361 57 0.15789473684210525 0.20249978775061067 +biopsy UQ_B29 VLP121_D PLAU 361 13 0.036011080332409975 0.044724690762341965 +biopsy UQ_B29 VLP121_D PLAT 361 6 0.01662049861495845 0.02182847283522589 +biopsy UQ_B29 VLP121_D TIMP1 361 202 0.5595567867036011 0.9109769108325232 +biopsy UQ_B29 VLP121_D TIMP2 361 62 0.17174515235457063 0.24733947090060465 +biopsy UQ_B30 VLP121_D SERPINE1 405 66 0.16296296296296298 0.16490196445124342 +biopsy UQ_B30 VLP121_D SPON1 405 8 0.019753086419753086 0.01800907196771118 +biopsy UQ_B30 VLP121_D ITGAV 405 20 0.04938271604938271 0.04682592910377364 +biopsy UQ_B30 VLP121_D ITGB5 405 94 0.23209876543209876 0.22815751291354022 +biopsy UQ_B30 VLP121_D MMP2 405 36 0.08888888888888889 0.08760146467374523 +biopsy UQ_B30 VLP121_D MMP9 405 0 0.0 0.0 +biopsy UQ_B30 VLP121_D MMP14 405 55 0.13580246913580246 0.13444321309568544 +biopsy UQ_B30 VLP121_D PLAU 405 2 0.0049382716049382715 0.0034347718501706224 +biopsy UQ_B30 VLP121_D PLAT 405 5 0.012345679012345678 0.010133665115834812 +biopsy UQ_B30 VLP121_D TIMP1 405 167 0.4123456790123457 0.4493926015246486 +biopsy UQ_B30 VLP121_D TIMP2 405 49 0.12098765432098765 0.12117620043860128 +biopsy UQ_B31 VLP121_D SERPINE1 189 32 0.1693121693121693 0.14294252532469112 +biopsy UQ_B31 VLP121_D SPON1 189 1 0.005291005291005291 0.0037149010847372555 +biopsy UQ_B31 VLP121_D ITGAV 189 18 0.09523809523809523 0.08046732889491746 +biopsy UQ_B31 VLP121_D ITGB5 189 47 0.24867724867724866 0.22387847957414705 +biopsy UQ_B31 VLP121_D MMP2 189 20 0.10582010582010581 0.09338907121130641 +biopsy UQ_B31 VLP121_D MMP9 189 2 0.010582010582010581 0.00884467686957871 +biopsy UQ_B31 VLP121_D MMP14 189 25 0.13227513227513227 0.11782434605425735 +biopsy UQ_B31 VLP121_D PLAU 189 7 0.037037037037037035 0.02159041594668115 +biopsy UQ_B31 VLP121_D PLAT 189 10 0.05291005291005291 0.04715084479397693 +biopsy UQ_B31 VLP121_D TIMP1 189 79 0.41798941798941797 0.40236872829575093 +biopsy UQ_B31 VLP121_D TIMP2 189 35 0.18518518518518517 0.16664393281393233 +biopsy UQ_B32 VLP121_D SERPINE1 284 59 0.20774647887323944 0.20230813346748916 +biopsy UQ_B32 VLP121_D SPON1 284 16 0.056338028169014086 0.05840780842901759 +biopsy UQ_B32 VLP121_D ITGAV 284 46 0.1619718309859155 0.14478783266778106 +biopsy UQ_B32 VLP121_D ITGB5 284 78 0.2746478873239437 0.27852950980673835 +biopsy UQ_B32 VLP121_D MMP2 284 83 0.29225352112676056 0.2997781385378091 +biopsy UQ_B32 VLP121_D MMP9 284 3 0.01056338028169014 0.011977533145756582 +biopsy UQ_B32 VLP121_D MMP14 284 82 0.2887323943661972 0.3088071414106078 +biopsy UQ_B32 VLP121_D PLAU 284 6 0.02112676056338028 0.019227497615913115 +biopsy UQ_B32 VLP121_D PLAT 284 11 0.03873239436619718 0.02890347901799335 +biopsy UQ_B32 VLP121_D TIMP1 284 202 0.7112676056338029 1.1019775472815923 +biopsy UQ_B32 VLP121_D TIMP2 284 71 0.25 0.23965189141653184 +biopsy UQ_B33 VLP121_D SERPINE1 444 101 0.22747747747747749 0.24801639819528928 +biopsy UQ_B33 VLP121_D SPON1 444 25 0.05630630630630631 0.059441772679961265 +biopsy UQ_B33 VLP121_D ITGAV 444 74 0.16666666666666666 0.17272634665912137 +biopsy UQ_B33 VLP121_D ITGB5 444 117 0.2635135135135135 0.2759577019258406 +biopsy UQ_B33 VLP121_D MMP2 444 116 0.26126126126126126 0.29344699384017375 +biopsy UQ_B33 VLP121_D MMP9 444 1 0.0022522522522522522 0.0022265845600988278 +biopsy UQ_B33 VLP121_D MMP14 444 118 0.26576576576576577 0.2850008900330604 +biopsy UQ_B33 VLP121_D PLAU 444 25 0.05630630630630631 0.06195378306421193 +biopsy UQ_B33 VLP121_D PLAT 444 18 0.04054054054054054 0.038303228682469534 +biopsy UQ_B33 VLP121_D TIMP1 444 328 0.7387387387387387 1.2321483173470134 +biopsy UQ_B33 VLP121_D TIMP2 444 103 0.23198198198198197 0.25428894769154803 diff --git a/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_patient_summary.tsv b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_patient_summary.tsv new file mode 100644 index 0000000..9fde8c7 --- /dev/null +++ b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_patient_summary.tsv @@ -0,0 +1,8 @@ +outcome n_patients median mean positive_fraction bootstrap_median_ci_low bootstrap_median_ci_high wilcoxon_signed_rank_p wilcoxon_fdr +antiproteolytic_brake 32 0.0962369663898365 0.10912273166325524 0.8125 0.046943715953258976 0.14007746865017184 6.794929504394531e-06 1.5854835510253906e-05 +clearance_inefficiency 32 0.04518933843707411 0.05564844677661064 0.6875 0.008903096167683673 0.0849756052683236 0.015647762920707464 0.02190686808899045 +feedback_core 32 0.044704849685144085 0.07806361823797363 0.8125 0.02803086538089938 0.08696471719544 3.175297752022743e-05 5.5567710660398006e-05 +feedback_lock 32 -0.023447864453006173 -0.022915513981759575 0.3125 -0.04017984220456823 -0.0008292172512048131 0.1544793052598834 0.18022585613653064 +mechanical_barrier 32 -0.002430600077630175 0.028354984489265524 0.46875 -0.055144268677770614 0.05165874490295758 0.9632332162000239 0.9632332162000239 +protease_activation_potential 32 0.052632542287045565 0.05347428488664459 0.875 0.027835198669857848 0.06950458349879383 1.1059455573558807e-06 3.870809450745583e-06 +proteolysis 32 0.06442537471911261 0.07722698754314652 0.90625 0.03633194536320113 0.11276596110220471 4.977919161319733e-07 3.484543412923813e-06 diff --git a/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_spot_scores.parquet b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_spot_scores.parquet new file mode 100644 index 0000000..e32a9cd Binary files /dev/null and b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_spot_scores.parquet differ diff --git a/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_stage_trends.tsv b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_stage_trends.tsv new file mode 100644 index 0000000..11c6e24 --- /dev/null +++ b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_stage_trends.tsv @@ -0,0 +1,20 @@ +analysis feature n_patients stage_beta_array_adjusted stage_beta_hc3_se stage_beta_hc3_p stage_beta_within_array_permutation_p spearman_rho spearman_p permutation_fdr_within_analysis +scar_coupling antiproteolytic_brake 32 0.05444868239040168 0.01833442424503473 0.002980408155518311 0.0034 0.6306354325067455 0.00010927119352772126 0.023799999999999998 +scar_coupling clearance_inefficiency 32 0.04130936036772251 0.017591472171352242 0.018861321522339658 0.0134 0.5090263311935044 0.0029275748514700634 0.03126666666666667 +scar_coupling feedback_core 32 0.039802896941248965 0.017020362107774075 0.019358950801726765 0.0112 0.6317649288037724 0.0001052905258438904 0.03126666666666667 +scar_coupling feedback_lock 32 -9.713809785227498e-05 0.015914262011160883 0.995129871103977 0.9944 0.21554554334932047 0.2361013465244376 0.9944 +scar_coupling mechanical_barrier 32 0.0354518311617599 0.030633674077732605 0.2471567444023829 0.2047 0.35296759282093965 0.047530028651929325 0.23881666666666668 +scar_coupling protease_activation_potential 32 0.013139322022679149 0.005294870478747754 0.013082371297548141 0.0661 0.4566930027645864 0.008601901613468734 0.09254000000000001 +scar_coupling proteolysis 32 0.02377861964068983 0.00847301437916501 0.005009933901099763 0.0235 0.493589881800802 0.0040941269405871126 0.041125 +barrier_partial_correlation Endo_resolver 32 0.07628294371304813 0.049502941502102785 0.12332214081136116 0.1497 0.2469831902832388 0.17295091702606863 0.5988 +barrier_partial_correlation HSC_retention 32 -0.03139265338465999 0.054107172099619114 0.5617838395235555 0.4859 -0.23229973842188772 0.20075965875980464 0.7518666666666666 +barrier_partial_correlation LAM_resolver 32 0.022188384719048486 0.04877107565867612 0.6491454487266373 0.5639 0.010918464204594398 0.9527064159255018 0.7518666666666666 +barrier_partial_correlation TGFb_integrator 32 -0.013732500926232717 0.08570706594368831 0.8727030436225922 0.8636 -0.10579615315486297 0.564423332531481 0.8636 +biopsy_mean mechanical_barrier 32 -0.12609889206709873 0.05584507814352326 0.02394487169973643 0.0096 -0.465164224992289 0.007304842584101721 0.010971428571428571 +biopsy_mean feedback_core 32 0.06043934681562625 0.022234477451329993 0.006562396143398023 0.0004 0.6063512621206648 0.00023460119535287125 0.00064 +biopsy_mean proteolysis 32 0.10370881986211569 0.027444357694820377 0.00015753795256113047 0.0001 0.732478348622014 1.8806354814163528e-06 0.0002 +biopsy_mean feedback_lock 32 -0.043269473046489426 0.014499437022905641 0.0028430464060753237 0.0051 -0.47627093857972125 0.0058593495557640275 0.0068000000000000005 +biopsy_mean protease_activation_potential 32 0.08357663461325976 0.02277598097171339 0.0002430181408828607 0.0001 0.7339843436847165 1.7473885911746434e-06 0.0002 +biopsy_mean antiproteolytic_brake 32 0.10013212303190733 0.025552932814997674 8.90589872038529e-05 0.0001 0.6396714028829615 8.08678893946375e-05 0.0002 +biopsy_mean clearance_inefficiency 32 0.016555488418647575 0.024800886036153904 0.5044297154379203 0.348 0.1731894322108077 0.34317098251799566 0.348 +biopsy_mean ECM_scar 32 0.17579958900504214 0.04289874902319988 4.167136522043404e-05 0.0001 0.7373728325757976 1.4784286609293653e-06 0.0002 diff --git a/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_summary.json b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_summary.json new file mode 100644 index 0000000..8692f7a --- /dev/null +++ b/data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_summary.json @@ -0,0 +1,46 @@ +{ + "n_spots": 13585, + "n_biopsies": 33, + "n_patients": 32, + "n_arrays": 8, + "primary_score": "z(SERPINE1)-mean[z(MMP2),z(MMP9)]", + "primary_scar_coupling": { + "outcome": "mechanical_barrier", + "n_patients": 32, + "median": -0.002430600077630175, + "mean": 0.028354984489265524, + "positive_fraction": 0.46875, + "bootstrap_median_ci_low": -0.055144268677770614, + "bootstrap_median_ci_high": 0.05165874490295758, + "wilcoxon_signed_rank_p": 0.9632332162000239, + "wilcoxon_fdr": 0.9632332162000239 + }, + "exploratory_clearance_inefficiency": { + "post_hoc": true, + "score": "mean[z(SERPINE1),z(TIMP1),z(TIMP2)]-mean[z(PLAU),z(PLAT),z(MMP2),z(MMP9),z(MMP14)]", + "scar_coupling": { + "outcome": "clearance_inefficiency", + "n_patients": 32, + "median": 0.04518933843707411, + "mean": 0.05564844677661064, + "positive_fraction": 0.6875, + "bootstrap_median_ci_low": 0.008903096167683673, + "bootstrap_median_ci_high": 0.0849756052683236, + "wilcoxon_signed_rank_p": 0.015647762920707464, + "wilcoxon_fdr": 0.02190686808899045 + }, + "stage_trend": { + "analysis": "scar_coupling", + "feature": "clearance_inefficiency", + "n_patients": 32, + "stage_beta_array_adjusted": 0.04130936036772251, + "stage_beta_hc3_se": 0.017591472171352242, + "stage_beta_hc3_p": 0.018861321522339658, + "stage_beta_within_array_permutation_p": 0.0134, + "spearman_rho": 0.5090263311935044, + "spearman_p": 0.0029275748514700634, + "permutation_fdr_within_analysis": 0.03126666666666667 + } + }, + "claim_boundary": "Spatial association after lineage and library adjustment; not cell-specific causality." +} diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_axis_definition_sensitivity.tsv b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_axis_definition_sensitivity.tsv new file mode 100644 index 0000000..b88dfe0 --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_axis_definition_sensitivity.tsv @@ -0,0 +1,4 @@ +axis_definition resolver_column lock_column bic_gain_one_to_two n_patients stage_beta hc3_se hc3_p within_array_permutation_p spearman_rho permutation_fdr +pca_primary resolver_axis lock_axis 141.01218590066708 32 0.08210263761216538 0.02607662330614558 0.001641023444792728 0.0006 0.5876135741248465 0.0018 +mechanistic_equal resolver_mechanistic_equal lock_mechanistic_equal 219.82349320980632 32 0.07714697772692802 0.02725331729606637 0.004644086889319471 0.0014 0.6059066441697332 0.0021 +compact_equal resolver_compact_equal lock_compact_equal 151.6566400194663 32 0.06478084191423046 0.024015755955938776 0.0069876787848987265 0.0044 0.5262392257995167 0.0044 diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_axis_feature_audit.tsv b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_axis_feature_audit.tsv new file mode 100644 index 0000000..061e7cb --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_axis_feature_audit.tsv @@ -0,0 +1,15 @@ +family feature covariates residual_sd raw_residual_r axis loading explained_variance +lock HSC_retention HSC_identity;log_library;array_fixed_effects 1.0 0.8699752198299 +lock feedback_core HSC_identity;log_library;array_fixed_effects 0.9999999999999999 0.9710024303444162 +lock clearance_inefficiency HSC_identity;Myeloid_identity;log_library;array_fixed_effects 1.0 0.9962832785464548 +lock TGFb_integrator HSC_identity;Myeloid_identity;log_library;array_fixed_effects 1.0 0.9137383376213086 +resolver Endo_resolver Endo_identity;HSC_identity;log_library;array_fixed_effects 1.0 0.8894174061893755 +resolver LAM_resolver Myeloid_identity;HSC_identity;log_library;array_fixed_effects 0.9999999999999999 0.8970267794769864 +aux antiproteolytic_brake HSC_identity;Myeloid_identity;log_library;array_fixed_effects 1.0 0.9282409306973035 +aux protease_activation_potential HSC_identity;Myeloid_identity;log_library;array_fixed_effects 1.0 0.8843991043562215 + HSC_retention lock 0.613843922352475 0.43998709356340304 + feedback_core lock 0.6250384573322986 0.43998709356340304 + clearance_inefficiency lock 0.3656396896908503 0.43998709356340304 + TGFb_integrator lock 0.314372681970568 0.43998709356340304 + Endo_resolver resolver 0.7071067811865506 0.5261020634995429 + LAM_resolver resolver 0.7071067811865446 0.5261020634995429 diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_basin_summary.json b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_basin_summary.json new file mode 100644 index 0000000..f93d1f2 --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_basin_summary.json @@ -0,0 +1,76 @@ +{ + "n_spots": 13585, + "n_biopsies": 33, + "n_patients": 32, + "n_spatial_blocks": 589, + "best_gmm_components": 2, + "bic_gain_one_to_two": 141.01218590066708, + "patient_bootstrap_multibasin_fraction": 1.0, + "leave_one_patient_out": { + "median_posterior_r": 0.9995959902588478, + "median_posterior_mae": 0.006976557223550208, + "median_basin_agreement": 1.0, + "minimum_basin_agreement": 0.9722222222222222 + }, + "locked_fraction_stage_trend": { + "basin_state": "locked", + "n_patients": 32, + "stage_beta": 0.038613280898779544, + "hc3_se": 0.008585501285919653, + "hc3_p": 6.8757580323628966e-06, + "within_array_permutation_p": 0.0001, + "spearman_rho": 0.6246114522559348, + "permutation_fdr": 0.00030000000000000003 + }, + "axis_definition_sensitivity": [ + { + "axis_definition": "pca_primary", + "resolver_column": "resolver_axis", + "lock_column": "lock_axis", + "bic_gain_one_to_two": 141.01218590066708, + "n_patients": 32, + "stage_beta": 0.08210263761216538, + "hc3_se": 0.02607662330614558, + "hc3_p": 0.001641023444792728, + "within_array_permutation_p": 0.0006, + "spearman_rho": 0.5876135741248465, + "permutation_fdr": 0.0018 + }, + { + "axis_definition": "mechanistic_equal", + "resolver_column": "resolver_mechanistic_equal", + "lock_column": "lock_mechanistic_equal", + "bic_gain_one_to_two": 219.82349320980632, + "n_patients": 32, + "stage_beta": 0.07714697772692802, + "hc3_se": 0.02725331729606637, + "hc3_p": 0.004644086889319471, + "within_array_permutation_p": 0.0014, + "spearman_rho": 0.6059066441697332, + "permutation_fdr": 0.0021 + }, + { + "axis_definition": "compact_equal", + "resolver_column": "resolver_compact_equal", + "lock_column": "lock_compact_equal", + "bic_gain_one_to_two": 151.6566400194663, + "n_patients": 32, + "stage_beta": 0.06478084191423046, + "hc3_se": 0.024015755955938776, + "hc3_p": 0.0069876787848987265, + "within_array_permutation_p": 0.0044, + "spearman_rho": 0.5262392257995167, + "permutation_fdr": 0.0044 + } + ], + "matched_ECM_stage_memory": { + "test": "matched_ECM_resolver_stage_memory", + "n_blocks": 589, + "n_patients": 32, + "stage_beta_logit_locked": -0.025300022004231596, + "cluster_se": 0.06507265124256584, + "cluster_p": 0.6974266565339757, + "within_array_patient_permutation_p": 0.6881 + }, + "interpretation": "A robust two-basin resolver-lock landscape and a stage-invariant separatrix support thresholded basin switching as a therapeutic control principle." +} diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_biopsy_state_fractions.tsv b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_biopsy_state_fractions.tsv new file mode 100644 index 0000000..cbe963c --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_biopsy_state_fractions.tsv @@ -0,0 +1,100 @@ +biopsy_id patient_cluster array fibrosis_stage stage_numeric stage_group basin_state n_spots fraction +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late locked 237 0.6752136752136753 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late resolved 81 0.23076923076923078 +UQ_B01 UQ_P01 VLP115_A F3b 3.0 late transition 33 0.09401709401709402 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early locked 418 0.5895627644569816 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early resolved 211 0.29760225669957685 +UQ_B02 UQ_P02 VLP115_A F1 1.0 early transition 80 0.11283497884344147 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early locked 165 0.6346153846153846 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early resolved 65 0.25 +UQ_B03 UQ_P03 VLP115_A F1 1.0 early transition 30 0.11538461538461539 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early locked 237 0.5602836879432624 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early resolved 140 0.3309692671394799 +UQ_B04 UQ_P04 VLP115_A F1 1.0 early transition 46 0.10874704491725769 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late locked 331 0.6439688715953308 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late resolved 121 0.23540856031128404 +UQ_B05 UQ_P05 VLP116_D F3b 3.0 late transition 62 0.12062256809338522 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate locked 122 0.6192893401015228 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate resolved 42 0.2131979695431472 +UQ_B06 UQ_P06 VLP116_D F3a 3.0 intermediate transition 33 0.16751269035532995 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late locked 610 0.7279236276849642 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late resolved 136 0.162291169451074 +UQ_B07 UQ_P07 VLP116_D F4 4.0 late transition 92 0.10978520286396182 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early locked 377 0.6041666666666666 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early resolved 158 0.2532051282051282 +UQ_B08 UQ_P08 VLP116_D F0 0.0 early transition 89 0.14262820512820512 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early locked 147 0.6336206896551724 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early resolved 61 0.2629310344827586 +UQ_B09 UQ_P09 VLP119_A F1 1.0 early transition 24 0.10344827586206896 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late locked 339 0.7635135135135135 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late resolved 68 0.15315315315315314 +UQ_B10 UQ_P10 VLP119_A F3b 3.0 late transition 37 0.08333333333333333 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate locked 226 0.5885416666666666 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate resolved 115 0.2994791666666667 +UQ_B11 UQ_P11 VLP119_A F2 2.0 intermediate transition 43 0.11197916666666667 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early locked 384 0.6085578446909667 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early resolved 171 0.27099841521394613 +UQ_B12 UQ_P12 VLP119_A F1 1.0 early transition 76 0.12044374009508717 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late locked 144 0.7578947368421053 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late resolved 29 0.15263157894736842 +UQ_B13 UQ_P13 VLP119_D F4 4.0 late transition 17 0.08947368421052632 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early locked 221 0.5609137055837563 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early resolved 121 0.30710659898477155 +UQ_B14 UQ_P14 VLP119_D F1 1.0 early transition 52 0.1319796954314721 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early locked 89 0.5460122699386503 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early resolved 55 0.3374233128834356 +UQ_B15 UQ_P15 VLP119_D F1 1.0 early transition 19 0.1165644171779141 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early locked 362 0.7125984251968503 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early resolved 93 0.1830708661417323 +UQ_B16 UQ_P16 VLP119_D F1 1.0 early transition 53 0.10433070866141732 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early locked 199 0.6503267973856209 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early resolved 65 0.21241830065359477 +UQ_B17 UQ_P17 VLP120_A F0 0.0 early transition 42 0.13725490196078433 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early locked 229 0.5439429928741093 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early resolved 146 0.34679334916864607 +UQ_B18 UQ_P18 VLP120_A F0 0.0 early transition 46 0.10926365795724466 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate locked 346 0.6017391304347826 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate resolved 159 0.27652173913043476 +UQ_B19 UQ_P19 VLP120_A F3a 3.0 intermediate transition 70 0.12173913043478261 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late locked 437 0.7508591065292096 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late resolved 96 0.16494845360824742 +UQ_B20 UQ_P20 VLP120_A F4 4.0 late transition 49 0.08419243986254296 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late locked 61 0.7349397590361446 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late resolved 16 0.1927710843373494 +UQ_B21 UQ_SYNC VLP120_D F3b 3.0 late transition 6 0.07228915662650602 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late locked 236 0.696165191740413 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late resolved 64 0.1887905604719764 +UQ_B22 UQ_SYNC VLP120_D F3b 3.0 late transition 39 0.11504424778761062 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate locked 408 0.6580645161290323 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate resolved 140 0.22580645161290322 +UQ_B23 UQ_P23 VLP120_D F2 2.0 intermediate transition 72 0.11612903225806452 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early locked 375 0.6167763157894737 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early resolved 152 0.25 +UQ_B24 UQ_P24 VLP120_D F1 1.0 early transition 81 0.13322368421052633 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate locked 170 0.5089820359281437 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate resolved 124 0.3712574850299401 +UQ_B25 UQ_P25 VLP121_A F2 2.0 intermediate transition 40 0.11976047904191617 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late locked 346 0.7440860215053764 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late resolved 75 0.16129032258064516 +UQ_B26 UQ_P26 VLP121_A F4 4.0 late transition 44 0.09462365591397849 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late locked 359 0.6084745762711864 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late resolved 152 0.2576271186440678 +UQ_B27 UQ_P27 VLP121_A F4 4.0 late transition 79 0.13389830508474576 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late locked 74 0.6324786324786325 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late resolved 30 0.2564102564102564 +UQ_B28 UQ_P28 VLP121_A F4 4.0 late transition 13 0.1111111111111111 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late locked 245 0.6786703601108033 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late resolved 83 0.2299168975069252 +UQ_B29 UQ_P29 VLP121_D F4 4.0 late transition 33 0.09141274238227147 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early locked 237 0.5851851851851851 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early resolved 122 0.3012345679012346 +UQ_B30 UQ_P30 VLP121_D F0 0.0 early transition 46 0.11358024691358025 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early locked 98 0.5185185185185185 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early resolved 59 0.31216931216931215 +UQ_B31 UQ_P31 VLP121_D F0 0.0 early transition 32 0.1693121693121693 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late locked 195 0.6866197183098591 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late resolved 62 0.21830985915492956 +UQ_B32 UQ_P32 VLP121_D F3b 3.0 late transition 27 0.09507042253521127 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late locked 309 0.6959459459459459 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late resolved 89 0.20045045045045046 +UQ_B33 UQ_P33 VLP121_D F3b 3.0 late transition 46 0.1036036036036036 diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_dip_tests.tsv b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_dip_tests.tsv new file mode 100644 index 0000000..853404e --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_dip_tests.tsv @@ -0,0 +1,5 @@ +stage_group n_blocks dip dip_p +all 589 0.009067430356368818 0.9972 +early 251 0.01618522767011705 0.9676 +intermediate 90 0.027635164478399796 0.9328 +late 248 0.019364835459588916 0.8046 diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_gmm_model_selection.tsv b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_gmm_model_selection.tsv new file mode 100644 index 0000000..54e0775 --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_gmm_model_selection.tsv @@ -0,0 +1,6 @@ +n_components bic aic +1 1062.6542230781893 1040.7620921599314 +2 921.6420371775222 873.4793491573547 +3 934.5104804497006 860.0772353276236 +4 961.0973729926463 860.3935707686599 +5 984.6113183816393 857.6369590557433 diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_leave_one_patient_out.tsv b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_leave_one_patient_out.tsv new file mode 100644 index 0000000..89a8915 --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_leave_one_patient_out.tsv @@ -0,0 +1,33 @@ +patient_cluster n_blocks posterior_r posterior_mae basin_agreement +UQ_P01 18 0.9991879420492213 0.011755252443531561 1.0 +UQ_P02 18 0.9996287775167149 0.02576228524677186 1.0 +UQ_P03 18 0.9988535646939767 0.01372337940641629 1.0 +UQ_P04 18 0.9991918063698862 0.02113931260772125 1.0 +UQ_P05 18 0.9998229727177204 0.006956867871499384 1.0 +UQ_P06 18 0.9991605959760486 0.010953444645220405 1.0 +UQ_P07 18 0.9998345312019862 0.007573682506165179 1.0 +UQ_P08 18 0.9986054485925505 0.003370925660086402 1.0 +UQ_P09 18 0.9998404382694749 0.005455574771826183 1.0 +UQ_P10 18 0.9995632030009808 0.009527792281557148 1.0 +UQ_P11 18 0.9991198148624026 0.005336505087927003 1.0 +UQ_P12 18 0.9984989798370727 0.004711216048612845 1.0 +UQ_P13 18 0.9973588283064538 0.021241938812591604 1.0 +UQ_P14 18 0.9997871401086598 0.003948102711901393 1.0 +UQ_P15 18 0.9999548071627666 0.0034429605977579127 1.0 +UQ_P16 18 0.9992462212140517 0.011836212108824566 1.0 +UQ_P17 17 0.9996880752798438 0.006194993296747116 1.0 +UQ_P18 18 0.9998933636472704 0.006996246575601032 1.0 +UQ_P19 18 0.9998271887258858 0.003161005572473445 1.0 +UQ_P20 18 0.999914740855599 0.005893307655499913 1.0 +UQ_SYNC 36 0.99969877831403 0.007856693413276963 0.9722222222222222 +UQ_P23 18 0.9995408284454685 0.011656182581219903 1.0 +UQ_P24 18 0.9995177558488533 0.0029466797336978093 1.0 +UQ_P25 18 0.9985484028527726 0.006175181201634043 1.0 +UQ_P26 18 0.9997163102315869 0.005119476204944448 1.0 +UQ_P27 18 0.9999116015523938 0.0021939657531435623 1.0 +UQ_P28 14 0.9998842009976122 0.005957984200981663 1.0 +UQ_P29 18 0.9991511670672834 0.00787170230853576 1.0 +UQ_P30 18 0.9981626208911567 0.004243804948108835 1.0 +UQ_P31 18 0.9991883806179915 0.007365404218273429 1.0 +UQ_P32 18 0.9997093802526721 0.01150316469145693 1.0 +UQ_P33 18 0.9996928391301743 0.008125313540540496 1.0 diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_matched_ECM_blocks.parquet b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_matched_ECM_blocks.parquet new file mode 100644 index 0000000..5bdca6f Binary files /dev/null and b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_matched_ECM_blocks.parquet differ diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_matched_ECM_memory_test.tsv b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_matched_ECM_memory_test.tsv new file mode 100644 index 0000000..5d7c4c5 --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_matched_ECM_memory_test.tsv @@ -0,0 +1,2 @@ +test n_blocks n_patients stage_beta_logit_locked cluster_se cluster_p within_array_patient_permutation_p +matched_ECM_resolver_stage_memory 589 32 -0.025300022004231596 0.06507265124256584 0.6974266565339757 0.6881 diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_patient_bootstrap_multibasin.tsv b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_patient_bootstrap_multibasin.tsv new file mode 100644 index 0000000..9b34203 --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_patient_bootstrap_multibasin.tsv @@ -0,0 +1,301 @@ +iteration best_k bic_gain_1_to_3 multibasin_supported +0 2 92.09191454299753 True +1 2 193.7712533938368 True +2 2 154.9177532589298 True +3 2 92.39811935061857 True +4 2 172.78178069333444 True +5 2 91.10340691483714 True +6 2 208.7484679605086 True +7 2 77.94693380578167 True +8 2 132.94153476019972 True +9 2 92.19451604687765 True +10 2 113.49202987176716 True +11 4 117.40790623629982 True +12 2 189.7443615830557 True +13 2 59.752672941747164 True +14 2 91.25599346209628 True +15 2 17.410218097264988 True +16 2 112.12239473523937 True +17 2 108.42451994292708 True +18 2 104.67491576455097 True +19 3 86.91814402954901 True +20 2 98.50862887931203 True +21 2 159.71079761841776 True +22 2 72.93658929559876 True +23 2 95.6937246158102 True +24 2 190.9561766965562 True +25 2 133.5042948967557 True +26 2 219.23693724643715 True +27 3 197.87750565298188 True +28 2 115.66899235261963 True +29 2 88.91788569522464 True +30 2 160.58388213085902 True +31 3 226.1551864864765 True +32 2 143.09447716998136 True +33 3 94.86425925531603 True +34 2 37.75126825547159 True +35 3 120.68299930424905 True +36 2 116.81921495225674 True +37 3 151.93123535474342 True +38 2 163.76640362120293 True +39 2 91.26449716966442 True +40 2 157.55081171037546 True +41 2 72.34687735347211 True +42 3 62.406783681450065 True +43 2 160.41109877985275 True +44 2 87.87406820651108 True +45 2 61.953291634087805 True +46 3 83.09558637273324 True +47 2 111.41696479281222 True +48 2 58.7141672883256 True +49 2 127.86469564972754 True +50 3 197.94981878892418 True +51 2 73.0565622114957 True +52 2 210.93767119981044 True +53 2 73.55944290599405 True +54 2 86.87390950882991 True +55 2 144.29729006678474 True +56 2 118.52746055225987 True +57 2 119.90669307967744 True +58 2 106.8640962770155 True +59 2 231.30199501399227 True +60 2 95.68737737255265 True +61 2 145.00276611520326 True +62 2 82.32767212651584 True +63 3 100.82774194015713 True +64 2 149.17933441585205 True +65 2 69.20069341310307 True +66 3 116.05480652299843 True +67 2 187.2885436947589 True +68 2 174.8001424693765 True +69 2 134.12797204942603 True +70 3 184.8873806712379 True +71 2 86.79629118372964 True +72 2 170.13370795571177 True +73 2 90.1709562410258 True +74 3 158.83411022582277 True +75 2 127.13701139553473 True +76 3 164.20711799090952 True +77 2 79.27567514043676 True +78 2 106.87789048419017 True +79 2 77.70020427352824 True +80 2 59.20427164541911 True +81 2 101.76320309336836 True +82 4 150.64070274360733 True +83 2 74.53153943308996 True +84 2 108.82243893526265 True +85 4 81.7880700004464 True +86 2 218.361689631731 True +87 4 159.01596743377468 True +88 2 113.28136248357555 True +89 2 114.3591674863136 True +90 2 68.34011528302938 True +91 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0.07149404216315307 +UQ_B30 UQ_P30 early transition transition 15 0.013748854262144821 +UQ_B30 UQ_P30 early locked resolved 345 0.3162236480293309 +UQ_B30 UQ_P30 early locked transition 138 0.12648945921173235 +UQ_B30 UQ_P30 early locked locked 391 0.35838680109990834 +UQ_B31 UQ_P31 early resolved resolved 39 0.08297872340425531 +UQ_B31 UQ_P31 early resolved transition 50 0.10638297872340426 +UQ_B31 UQ_P31 early transition transition 11 0.023404255319148935 +UQ_B31 UQ_P31 early locked resolved 154 0.3276595744680851 +UQ_B31 UQ_P31 early locked transition 91 0.19361702127659575 +UQ_B31 UQ_P31 early locked locked 125 0.26595744680851063 +UQ_B32 UQ_P32 late resolved resolved 29 0.03871829105473965 +UQ_B32 UQ_P32 late resolved transition 33 0.044058744993324434 +UQ_B32 UQ_P32 late transition transition 13 0.017356475300400534 +UQ_B32 UQ_P32 late locked resolved 223 0.2977303070761015 +UQ_B32 UQ_P32 late locked transition 78 0.1041388518024032 +UQ_B32 UQ_P32 late locked locked 373 0.4979973297730307 +UQ_B33 UQ_P33 late resolved resolved 58 0.048576214405360134 +UQ_B33 UQ_P33 late resolved transition 49 0.04103852596314908 +UQ_B33 UQ_P33 late transition transition 17 0.01423785594639866 +UQ_B33 UQ_P33 late locked resolved 294 0.24623115577889448 +UQ_B33 UQ_P33 late locked transition 166 0.1390284757118928 +UQ_B33 UQ_P33 late locked locked 610 0.5108877721943048 diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spatial_blocks.parquet b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spatial_blocks.parquet new file mode 100644 index 0000000..86eb1c1 Binary files /dev/null and b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spatial_blocks.parquet differ diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spot_states.parquet b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spot_states.parquet new file mode 100644 index 0000000..a1486ce Binary files /dev/null and b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spot_states.parquet differ diff --git a/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_state_fraction_trends.tsv b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_state_fraction_trends.tsv new file mode 100644 index 0000000..c23398e --- /dev/null +++ b/data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_state_fraction_trends.tsv @@ -0,0 +1,4 @@ +basin_state n_patients stage_beta hc3_se hc3_p within_array_permutation_p spearman_rho permutation_fdr +resolved 32 -0.02926402829515349 0.007735061534817672 0.0001547651033401755 0.0003 -0.5768489751633514 0.00045 +transition 32 -0.00934925260362628 0.002993995695403677 0.0017922018420368422 0.0009 -0.4841774126589103 0.0009000000000000001 +locked 32 0.038613280898779544 0.008585501285919653 6.8757580323628966e-06 0.0001 0.6246114522559348 0.00030000000000000003 diff --git a/data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/LINCS_ordered_basin_switch_pairs.tsv b/data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/LINCS_ordered_basin_switch_pairs.tsv new file mode 100644 index 0000000..555aa9c --- /dev/null +++ b/data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/LINCS_ordered_basin_switch_pairs.tsv @@ -0,0 +1,300 @@ +early_compound late_compound forward_score reverse_score order_advantage early_mean_resolver early_resolver_floor early_retention late_retention late_q25_retention late_resolver_floor early_tier late_tier both_named both_hard_gate forward_percentile order_percentile basin_switch_index basin_switch_rank +ezetimibe aliskiren 0.991250659782617 0.4635385405493989 0.527712119233218 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9832775919732442 0.9832775919732442 0.9832775919732442 1 +ezetimibe prednisone 0.9586663077888448 0.41124356563188247 0.5474227421569623 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9732441471571907 0.9966555183946488 0.981438127090301 2 +r(-)-propylnorapomorphine aliskiren 0.9556010816660192 0.421358848153244 0.5342422335127752 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9698996655518395 0.9899665551839465 0.976923076923077 3 +panobinostat prednisone 0.9964218039826918 0.5280599711566335 0.46836183282605826 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.9866220735785953 0.939799331103679 0.9702341137123747 4 +panobinostat aliskiren 1.029006155976464 0.58035494607415 0.4486512099023141 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.9966555183946488 0.9163879598662207 0.968561872909699 5 +r(-)-propylnorapomorphine prednisone 0.9230167296722471 0.36906387323572754 0.5539528564365196 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9431438127090301 1.0 0.9630434782608696 6 +ezetimibe psb-069 1.0094935946935226 0.5710814891102176 0.438412105583305 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.9933110367892977 0.8996655518394648 0.9605351170568561 7 +r(-)-propylnorapomorphine psb-069 0.9738440165769249 0.5289017967140627 0.4449422198628622 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.979933110367893 0.9096989966555183 0.9553511705685618 8 +stk-249718 aliskiren 0.9182493440836432 0.39761467224046126 0.520634671843182 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9364548494983278 0.979933110367893 0.9516722408026757 9 +ezetimibe bromocriptine 0.9102166814171517 0.4344725208643396 0.47574416055281216 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9331103678929766 0.9498327759197325 0.9389632107023411 10 +stk-249718 psb-069 0.9364922789945489 0.5051576208012799 0.431334658193269 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.9565217391304348 0.8896321070234113 0.9331103678929766 11 +ezetimibe pd-0325901 0.9036995703834922 0.4199196235350673 0.48377994684842496 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9163879598662207 0.9632107023411371 0.9327759197324414 12 +stk-249718 prednisone 0.8856649920898712 0.34531969732294476 0.5403452947669264 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8929765886287625 0.9933110367892977 0.9280936454849498 13 +thiostrepton aliskiren 0.8916110471186658 0.3982615905207776 0.4933494565978882 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.8996655518394648 0.9698996655518395 0.9242474916387959 14 +panobinostat pd-0325901 0.9414550665773392 0.5367360290598184 0.4047190375175208 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.959866220735786 0.8528428093645485 0.9224080267558529 15 +panobinostat bromocriptine 0.9479721776109987 0.5512889263890906 0.3966832512219082 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.9665551839464883 0.8361204013377926 0.9209030100334448 16 +y-26763 prednisone 0.8770943327016003 0.3436154609339103 0.5334788717676899 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_3_computational_hit Tier_4_not_prioritized True False 0.8795986622073578 0.9866220735785953 0.9170568561872909 17 +y-26763 aliskiren 0.9096786846953725 0.47322606065473144 0.43645262404064106 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_3_computational_hit Tier_4_not_prioritized True False 0.9264214046822743 0.8929765886287625 0.9147157190635452 18 +panobinostat psb-069 1.0472490908873695 0.6878978946349686 0.35935119625240086 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True True 1.0 0.7290969899665551 0.9051839464882943 19 +r(-)-propylnorapomorphine bromocriptine 0.874567103300554 0.39229282846818464 0.48227427483236934 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8729096989966555 0.959866220735786 0.9033444816053512 20 +thiostrepton psb-069 0.9098539820295715 0.5058045390815962 0.4040494429479753 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True False 0.9297658862876255 0.842809364548495 0.8993311036789298 21 +r(-)-propylnorapomorphine pd-0325901 0.8680499922668945 0.3777399311389124 0.4903100611279821 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.862876254180602 0.9665551839464883 0.8991638795986622 22 +thiostrepton prednisone 0.8590266951248936 0.3459666156032611 0.5130600795216325 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.8528428093645485 0.9765886287625418 0.8961538461538461 23 +ezetimibe verteporfin 0.8923123237262998 0.5041988742064742 0.3881134495198255 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.9063545150501672 0.8093645484949833 0.8724080267558529 24 +ezetimibe wz-4002 0.9652742582820504 0.6285826451152504 0.33669161316679996 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.9765886287625418 0.6688963210702341 0.8688963210702341 25 +stk-249718 bromocriptine 0.837215365718178 0.36854865255540187 0.46866671316277614 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8193979933110368 0.9431438127090301 0.8627090301003344 26 +y-26763 psb-069 0.9279216196062781 0.5807690092155502 0.34715261039072787 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_3_computational_hit Tier_3_computational_hit True True 0.9464882943143813 0.6989966555183946 0.8598662207357859 27 +stk-249718 pd-0325901 0.8306982546845185 0.35399575522612964 0.4767024994583889 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8060200668896321 0.9565217391304348 0.8586956521739131 28 +r(-)-propylnorapomorphine wz-4002 0.9296246801654527 0.5864029527190955 0.34322172744635726 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.9498327759197325 0.6822742474916388 0.8561872909698997 29 +aminopentamide aliskiren 0.833238133998026 0.3769485101709882 0.45628962382703786 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8160535117056856 0.9264214046822743 0.8546822742474917 30 +ezetimibe nvp-tae684 0.9061188932826063 0.5477355869546059 0.3583833063280004 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.919732441471572 0.725752508361204 0.8518394648829433 31 +pre-084 prednisone 0.8450637823672935 0.4211918654304647 0.4238719169368288 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.8294314381270903 0.882943143812709 0.8481605351170568 32 +r(-)-propylnorapomorphine verteporfin 0.856662745609702 0.4620191818103194 0.3946435637993826 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.8494983277591973 0.8294314381270903 0.8424749163879599 33 +panobinostat verteporfin 0.9300678199201469 0.6210152797312254 0.3090525401889215 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True True 0.9531772575250836 0.6020066889632107 0.8302675585284282 34 +pre-084 aliskiren 0.8776481343610656 0.5214680867225286 0.35618004763853695 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.882943143812709 0.7224080267558528 0.8267558528428094 35 +r(-)-propylnorapomorphine nvp-tae684 0.8704693151660086 0.505555894558451 0.3649134206075576 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8695652173913043 0.7424749163879598 0.8250836120401337 36 +stk-249718 wz-4002 0.8922729425830767 0.5626587768063127 0.32961416577676395 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.903010033444816 0.6521739130434783 0.8152173913043478 37 +thiostrepton bromocriptine 0.8105770687532006 0.36919557083571813 0.44138149791748243 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.7625418060200669 0.903010033444816 0.811705685618729 38 +prochlorperazine aliskiren 0.8278346426991953 0.4319884201792616 0.3958462225199337 0.3393047527809228 0.148764285658087 0.0186749911970562 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.7959866220735786 0.8327759197324415 0.8088628762541805 39 +aminopentamide psb-069 0.8514810689089316 0.48449145873180693 0.36698961017712467 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.8361204013377926 0.745819397993311 0.804515050167224 40 +aminopentamide prednisone 0.8006537820042539 0.3246535352534718 0.47600024675078206 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.7224080267558528 0.9531772575250836 0.8031772575250836 41 +thiostrepton pd-0325901 0.8040599577195411 0.35464267350644596 0.4494172842130951 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.7391304347826086 0.919732441471572 0.8023411371237459 42 +panobinostat nvp-tae684 0.9438743894764533 0.664551992479357 0.27932239699709627 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.9632107023411371 0.5016722408026756 0.8016722408026756 43 +y-26763 pd-0325901 0.8221275952962478 0.42960714364039987 0.3925204516558479 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_3_computational_hit Tier_4_not_prioritized True False 0.7892976588628763 0.822742474916388 0.8010033444816054 44 +y-26763 bromocriptine 0.8286447063299074 0.44416004096967204 0.38448466536023534 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_3_computational_hit Tier_4_not_prioritized True False 0.7993311036789298 0.802675585284281 0.8005016722408027 45 +panobinostat wz-4002 1.0030297544758975 0.7453990506400014 0.25763070383589604 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True True 0.9899665551839465 0.43812709030100333 0.7968227424749165 46 +loperamide prednisone 0.8322542188947812 0.4556978701776454 0.37655634871713584 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8093645484949833 0.7692307692307693 0.7953177257525084 47 +panobinostat glycocholic-acid 0.8301217698654721 0.4582515775063445 0.37187019235912766 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.802675585284281 0.7591973244147158 0.7874581939799331 48 +stk-249718 verteporfin 0.819311008027326 0.43827500589753665 0.3810360021297894 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.782608695652174 0.7859531772575251 0.7837792642140469 49 +prochlorperazine prednisone 0.7952502907054231 0.3499372028523966 0.4453130878530265 0.3393047527809228 0.148764285658087 0.0186749911970562 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.7123745819397993 0.9130434782608695 0.7826086956521738 50 +stk-249718 nvp-tae684 0.8331175775836326 0.48181171864566824 0.35130585893796434 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8127090301003345 0.7123745819397993 0.7775919732441472 51 +ezetimibe glycocholic-acid 0.7923662736716252 0.34143517198159345 0.4509311016900317 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6989966555183946 0.9230769230769231 0.7774247491638796 52 +geldanamycin aliskiren 0.9008760851704413 0.6279409286226072 0.27293515654783407 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.9130434782608695 0.4916387959866221 0.7655518394648829 53 +ag-490 aliskiren 0.7893444688931581 0.3527509146517823 0.4365935542413758 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6889632107023411 0.8963210702341137 0.7615384615384615 54 +panobinostat pd-184352 0.8064069023304101 0.42205692930442706 0.38434997302598306 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.7424749163879598 0.7959866220735786 0.7612040133779264 55 +thiostrepton wz-4002 0.8656346456180992 0.5633056950866291 0.30232895053147013 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True False 0.8595317725752508 0.5652173913043478 0.7565217391304347 56 +pre-084 psb-069 0.8958910692719713 0.6290110352833473 0.2668800339886239 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_1_mechanistic_probe Tier_3_computational_hit True True 0.9096989966555183 0.46153846153846156 0.7528428093645485 57 +geldanamycin prednisone 0.8682917331766691 0.5714705826803331 0.29682115049633595 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.8662207357859532 0.5418060200668896 0.7526755852842809 58 +prochlorperazine psb-069 0.8460775776101009 0.5395313687400802 0.3065462088700207 0.3393047527809228 0.148764285658087 0.0186749911970562 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True True 0.8327759197324415 0.5886287625418061 0.7473244147157191 59 +ezetimibe pd-184352 0.768651406136563 0.30524052377967603 0.463410882356887 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6454849498327759 0.9364548494983278 0.7473244147157191 59 +r(-)-propylnorapomorphine glycocholic-acid 0.7567166955550275 0.25779289718244297 0.49892379837258455 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6187290969899666 0.9732441471571907 0.742809364548495 61 +ag-490 psb-069 0.8075874038040638 0.4602938632126011 0.3472935405914627 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.7591973244147158 0.7023411371237458 0.7392976588628762 62 +loperamide aliskiren 0.8648385708885533 0.5866812091054661 0.27815736178308725 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8561872909698997 0.4983277591973244 0.7309364548494983 63 +ag-490 prednisone 0.7567601168993859 0.3004559397342659 0.45630417716512006 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6220735785953178 0.9297658862876255 0.7297658862876255 64 +y-26763 wz-4002 0.883702283194806 0.6382701652205829 0.24543211797422315 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_3_computational_hit Tier_1_mechanistic_probe True True 0.8896321070234113 0.40468227424749165 0.7198996655518395 65 +thiostrepton verteporfin 0.7926727110623486 0.43892192417785303 0.35375078688449557 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True False 0.705685618729097 0.7190635451505016 0.7103678929765886 66 +ezetimibe tyrphostin-1 0.817842282310483 0.5113162649573668 0.30652601735311613 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.7759197324414716 0.5852842809364549 0.7091973244147158 67 +thiostrepton nvp-tae684 0.8064792806186551 0.4824586369259845 0.32402064369267064 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.745819397993311 0.6287625418060201 0.7048494983277591 68 +geldanamycin psb-069 0.9191190200813468 0.7354838771834258 0.18363514289792104 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True False 0.939799331103679 0.22742474916387959 0.6904682274247492 69 +r(-)-propylnorapomorphine pd-184352 0.7330018280199655 0.2630608313835211 0.4699409966364444 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5518394648829431 0.9464882943143813 0.6899665551839465 70 +aminopentamide bromocriptine 0.7522041556325608 0.34788249048592884 0.404321665146632 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6053511705685619 0.8461538461538461 0.6896321070234115 71 +arcyriaflavin-a prednisone 0.7864104255494321 0.4356065589698059 0.3508038665796262 0.25139682919585277 0.135857936926186 0.176811108055214 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6789297658862876 0.7090301003344481 0.6894648829431438 72 +y-26763 verteporfin 0.8107403486390554 0.5138863943118069 0.2968539543272485 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_3_computational_hit Tier_1_mechanistic_probe True True 0.7658862876254181 0.5451505016722408 0.688628762541806 73 +aminopentamide pd-0325901 0.7456870445989013 0.33332959315665667 0.41235745144224467 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5919732441471572 0.8662207357859532 0.6879598662207358 74 +y-26763 nvp-tae684 0.8245469181953617 0.5574231070599385 0.2671238111354233 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_3_computational_hit Tier_4_not_prioritized True False 0.7926421404682275 0.46488294314381273 0.6779264214046823 75 +arcyriaflavin-a aliskiren 0.8189947775432042 0.5461705752448843 0.27282420229831983 0.25139682919585277 0.135857936926186 0.176811108055214 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.7792642140468228 0.4882943143812709 0.6774247491638796 76 +panobinostat tyrphostin-1 0.85559777850433 0.628132670482118 0.2274651080222121 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True True 0.8461538461538461 0.3612040133779264 0.6764214046822743 77 +wz-4002 aliskiren 0.8878975514773398 0.6968770454109218 0.19102050606641807 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.8963210702341137 0.25418060200668896 0.671571906354515 78 +ezetimibe duloxetine 0.7540904474426208 0.3761590098969579 0.3779314375456629 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6120401337792643 0.7759197324414716 0.6693979933110368 79 +pre-084 bromocriptine 0.7966141559956004 0.4924020670374693 0.30421208895813107 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7157190635451505 0.5752508361204013 0.6665551839464883 80 +ezetimibe ambroxol 0.7397342591531693 0.3418128165741643 0.39792144257900497 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5719063545150501 0.8394648829431438 0.6655518394648829 81 +loperamide psb-069 0.8830815057994591 0.6942241576662849 0.18885734813317423 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.8862876254180602 0.24749163879598662 0.6627090301003344 82 +pre-084 pd-0325901 0.7900970449619409 0.4778491697081971 0.3122478752537438 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.6923076923076923 0.6053511705685619 0.6618729096989967 83 +wz-4002 prednisone 0.8553131994835677 0.6445820704934054 0.21073112899016222 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.842809364548495 0.3110367892976589 0.6566889632107024 84 +stk-249718 glycocholic-acid 0.7193649579726514 0.27551130367265575 0.4438536542999957 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5217391304347826 0.9063545150501672 0.6563545150501672 85 +ticlopidine aliskiren 0.7414480896910565 0.3614093916479587 0.38003869804309776 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5819397993311036 0.782608695652174 0.6521739130434783 86 +bibx-1382 aliskiren 0.7831141429820231 0.4674719324601547 0.31564221052186836 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6722408026755853 0.6120401337792643 0.6511705685618729 87 +ezetimibe tubocurarine 0.7220422201789916 0.3065483757028622 0.41549384447612936 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5317725752508361 0.8729096989966555 0.6511705685618729 87 +aminopentamide wz-4002 0.8072617324974596 0.5419926147368397 0.2652691177606199 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.7558528428093646 0.45484949832775917 0.6505016722408027 89 +r(-)-propylnorapomorphine tyrphostin-1 0.7821927041938853 0.46913657256121194 0.3130561316326734 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6688963210702341 0.6086956521739131 0.6478260869565218 90 +panobinostat duloxetine 0.7918459436364678 0.49297541542170886 0.2988705282147589 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.6956521739130435 0.5551839464882943 0.6464882943143813 91 +panobinostat ambroxol 0.7774897553470163 0.4586292220989153 0.31886053324810093 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.6588628762541806 0.6220735785953178 0.6459866220735786 92 +panobinostat tubocurarine 0.7597977163728387 0.42336478122761323 0.33643293514522543 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.6321070234113713 0.6655518394648829 0.6438127090301003 93 +ezetimibe atorvastatin 0.7381697335383957 0.3611505521712677 0.377019181367128 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.568561872909699 0.7725752508361204 0.6399665551839464 94 +ticlopidine prednisone 0.7088637376972843 0.2961581635939341 0.4127055741033502 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5016722408026756 0.8695652173913043 0.6304347826086956 95 +geldanamycin bromocriptine 0.819842106804976 0.5988749089375478 0.22096719786742824 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.7859531772575251 0.3411371237458194 0.6302675585284281 96 +geldanamycin pd-0325901 0.8133249957713166 0.5843220116082757 0.22900298416304088 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.7692307692307693 0.36789297658862874 0.6287625418060201 97 +prochlorperazine bromocriptine 0.7468006643337302 0.4029224004942022 0.34387826383952796 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.5953177257525084 0.6889632107023411 0.6280936454849498 98 +wz-4002 psb-069 0.9061404863882454 0.8044199939717405 0.10172049241650494 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_1_mechanistic_probe Tier_3_computational_hit True True 0.9230769230769231 0.07023411371237458 0.6245819397993312 99 +prochlorperazine pd-0325901 0.7402835533000706 0.38836950316492996 0.3519140501351406 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.5752508361204013 0.7157190635451505 0.6244147157190636 100 +stk-249718 pd-184352 0.6956500904375894 0.23931665547073838 0.456333434966851 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.45484949832775917 0.9331103678929766 0.6222408026755852 101 +bibx-1382 prednisone 0.750529790988251 0.41517695754263834 0.3353528334456127 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6020066889632107 0.6588628762541806 0.6219063545150502 102 +panobinostat atorvastatin 0.7759252297322429 0.47796695769601866 0.2979582720362242 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.6521739130434783 0.5518394648829431 0.6170568561872909 103 +r(-)-propylnorapomorphine duloxetine 0.7184408693260231 0.3339793175008029 0.38446155182522024 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5183946488294314 0.7993311036789298 0.6167224080267558 104 +pre-084 wz-4002 0.851671732860499 0.6865121912883801 0.16515954157211887 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.8394648829431438 0.1939799331103679 0.6135451505016724 105 +arcyriaflavin-a psb-069 0.8372377124541097 0.653713523805703 0.1835241886484067 0.25139682919585277 0.135857936926186 0.176811108055214 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.822742474916388 0.22408026755852842 0.6132107023411372 106 +r(-)-propylnorapomorphine ambroxol 0.7040846810365716 0.29963312417800936 0.40445155685856227 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.48494983277591974 0.8494983277591973 0.6125418060200669 107 +ag-490 bromocriptine 0.7083104905276929 0.32368489496672304 0.38462559556096987 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4983277591973244 0.8060200668896321 0.6060200668896321 108 +prednisolone-acetate aliskiren 0.7539784021986028 0.44535822486726656 0.30862017733133623 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6086956521739131 0.5986622073578596 0.6051839464882944 109 +thiostrepton glycocholic-acid 0.692726661007674 0.27615822195297207 0.4165684390547019 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.44816053511705684 0.8762541806020067 0.5979933110367892 110 +ticlopidine psb-069 0.7596910246019621 0.4689523402087774 0.29073868439318473 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.6287625418060201 0.5317725752508361 0.5948160535117057 111 +bibx-1382 psb-069 0.8013570778929286 0.5750148810209734 0.22634219687195523 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.725752508361204 0.3511705685618729 0.5946488294314382 112 +ag-490 pd-0325901 0.7017933794940333 0.3091319976374507 0.3926613818565826 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4682274247491639 0.8260869565217391 0.5934782608695652 113 +etomidate aliskiren 0.7889657141455996 0.5403857108368169 0.24858000330878272 0.2152146542710917 0.1923187635838985 0.189117331109527 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.68561872909699 0.4180602006688963 0.5919732441471571 114 +r(-)-propylnorapomorphine atorvastatin 0.7025201554217981 0.31897085977511275 0.3835492956466854 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4782608695652174 0.7926421404682275 0.5882943143812709 115 +geldanamycin wz-4002 0.8748996836698747 0.7929850331884587 0.081914650481416 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True False 0.8762541806020067 0.05016722408026756 0.5871237458193981 116 +y-26763 glycocholic-acid 0.7107942985843807 0.35112269208692604 0.35967160649745467 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_3_computational_hit Tier_4_not_prioritized True False 0.5050167224080268 0.7324414715719063 0.5846153846153845 117 +nu-7026 prednisone 0.6899139605913429 0.27947112679895414 0.4104428337923888 0.22968370221289142 0.121435706104551 0.0272444321049584 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.43478260869565216 0.862876254180602 0.5846153846153845 117 +r(-)-propylnorapomorphine tubocurarine 0.6863926420623938 0.2643686833067073 0.4220239587556865 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.42474916387959866 0.8795986622073578 0.5839464882943144 119 +nu-7026 aliskiren 0.722498312585115 0.3857473358031481 0.3367509767819669 0.22968370221289142 0.121435706104551 0.0272444321049584 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5351170568561873 0.6722408026755853 0.5831103678929765 120 +aminopentamide verteporfin 0.734299797941709 0.4176088438280637 0.3166909541136453 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5585284280936454 0.6187290969899666 0.5795986622073579 121 +etomidate prednisone 0.7563813621518275 0.47216731455502275 0.28421404759680474 0.2152146542710917 0.1923187635838985 0.189117331109527 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6153846153846154 0.5117056856187291 0.5790969899665552 122 +stk-249718 tyrphostin-1 0.7448409666115092 0.44539239664842917 0.29944856996308006 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5886287625418061 0.5585284280936454 0.5780936454849499 123 +prochlorperazine wz-4002 0.8018582411986288 0.597032524745113 0.20482571645351577 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True True 0.7290969899665551 0.28762541806020064 0.574581939799331 124 +aminopentamide nvp-tae684 0.7481063674980153 0.4611455565761952 0.2869608109218201 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5986622073578596 0.5284280936454849 0.5740802675585285 125 +prednisolone-acetate prednisone 0.7213940502048307 0.3930632499497501 0.3283308002550806 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5284280936454849 0.6488294314381271 0.5705685618729097 126 +thiostrepton pd-184352 0.669011793472612 0.23996357375105465 0.4290482197215573 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.3979933110367893 0.8862876254180602 0.568896321070234 127 +loperamide bromocriptine 0.7838045925230881 0.5576151894204067 0.22618940310268143 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6755852842809364 0.34782608695652173 0.5608695652173913 128 +loperamide pd-0325901 0.7772874814894286 0.5430622920911345 0.23422518939829406 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6555183946488294 0.3779264214046823 0.558361204013378 129 +ag-490 wz-4002 0.7633680673925916 0.5177950192176338 0.24557304817495773 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6387959866220736 0.4080267558528428 0.5580267558528429 130 +loperamide wz-4002 0.8388621693879869 0.7517253136713176 0.08713685571666929 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.8260869565217391 0.05351170568561873 0.555685618729097 131 +etomidate psb-069 0.8072086490565051 0.6479286593976354 0.1592799896588697 0.2152146542710917 0.1923187635838985 0.189117331109527 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.7525083612040134 0.1806020066889632 0.5523411371237459 132 +y-26763 pd-184352 0.6870794310493187 0.3149280438850086 0.37215138716431007 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_3_computational_hit Tier_4_not_prioritized True False 0.4280936454849498 0.7625418060200669 0.5451505016722409 133 +pre-084 verteporfin 0.7787097983047484 0.5621284203796042 0.2165813779251442 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.6622073578595318 0.3277591973244147 0.5451505016722408 134 +pre-084 nvp-tae684 0.792516367861055 0.6056651331277356 0.18685123473331933 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7023411371237458 0.2408026755852843 0.5408026755852843 135 +stk-249718 ambroxol 0.6667329434541955 0.27588894826522664 0.3908439951889689 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.391304347826087 0.8160535117056856 0.5399665551839465 136 +prednisolone-acetate psb-069 0.7722213371095085 0.5529011734280853 0.21932016368142315 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.6488294314381271 0.3311036789297659 0.5376254180602007 137 +wz-4002 bromocriptine 0.8068635731118745 0.6678110257258624 0.13905254738601214 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7491638795986622 0.13712374581939799 0.5349498327759197 138 +stk-249718 duloxetine 0.6810891317436472 0.3102351415880201 0.37085399015562703 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.41471571906354515 0.7525083612040134 0.532943143812709 139 +geldanamycin nvp-tae684 0.8157443186704305 0.7121379750278143 0.10360634364261623 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.7725752508361204 0.07692307692307693 0.5290969899665553 140 +emf-sumo1-10 aliskiren 0.6634220992407156 0.27386064726179327 0.38956145197892234 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3712374581939799 0.8127090301003345 0.525752508361204 141 +wz-4002 pd-0325901 0.8003464620782151 0.6532581283965901 0.147088333681625 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7190635451505016 0.16387959866220736 0.5247491638795986 142 +nu-7026 psb-069 0.7407412474960207 0.4932902843639667 0.24745096313205395 0.22968370221289142 0.121435706104551 0.0272444321049584 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.5785953177257525 0.41471571906354515 0.5212374581939799 143 +geldanamycin verteporfin 0.8019377491141241 0.6686012622796826 0.13333648683444144 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True False 0.7324414715719063 0.12374581939799331 0.5193979933110368 144 +stk-249718 tubocurarine 0.6490409044800178 0.24062450739392455 0.4084163970860933 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3277591973244147 0.8561872909698997 0.5127090301003344 145 +stk-249718 atorvastatin 0.6651684178394222 0.29522668386233 0.3699417339770922 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3779264214046823 0.7491638795986622 0.5078595317725753 146 +prochlorperazine nvp-tae684 0.7427028761991846 0.5161854665844685 0.22651740961471611 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.5852842809364549 0.35785953177257523 0.505685618729097 147 +prochlorperazine verteporfin 0.7288963066428782 0.472648753836337 0.2562475528065412 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True True 0.5451505016722408 0.431438127090301 0.5053511705685618 148 +thiostrepton tyrphostin-1 0.7182026696465318 0.4460393149287455 0.2721633547177863 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True False 0.5150501672240803 0.4816053511705686 0.5033444816053512 149 +arcyriaflavin-a bromocriptine 0.7379607991777389 0.5171045555598249 0.220856243617914 0.25139682919585277 0.135857936926186 0.176811108055214 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5652173913043478 0.3377926421404682 0.48561872909698994 150 +arcyriaflavin-a pd-0325901 0.7314436881440793 0.5025516582305528 0.22889202991352653 0.25139682919585277 0.135857936926186 0.176811108055214 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5484949832775919 0.36454849498327757 0.4841137123745819 151 +ag-490 nvp-tae684 0.7042127023931474 0.43694796105698935 0.267264741336158 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4882943143812709 0.4682274247491639 0.48127090301003345 152 +wz-4002 nvp-tae684 0.8027657849773292 0.7810740918161287 0.021691693161200454 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7357859531772575 0.006688963210702341 0.4806020066889632 153 +ag-490 verteporfin 0.6904061328368409 0.39341124830885776 0.29699488452798317 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.4414715719063545 0.5484949832775919 0.4789297658862876 154 +arcyriaflavin-a wz-4002 0.7930183760426377 0.7112146798107358 0.08180369623190187 0.25139682919585277 0.135857936926186 0.176811108055214 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.7090301003344481 0.046822742474916385 0.477257525083612 155 +emf-sumo1-10 prednisone 0.6308377472469434 0.22156567234427677 0.40927207490266665 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2709030100334448 0.8595317725752508 0.4769230769230769 156 +y-26763 tyrphostin-1 0.7362703072232386 0.5210037850626994 0.2152665221605392 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_3_computational_hit Tier_1_mechanistic_probe True True 0.5618729096989966 0.3177257525083612 0.47642140468227423 157 +emf-sumo1-10 psb-069 0.6816650341516213 0.38140359582261196 0.3002614383290093 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.4180602006688963 0.5618729096989966 0.4683946488294314 158 +bibx-1382 bromocriptine 0.702080164616558 0.43840591277509544 0.26367425184146254 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.47491638795986624 0.44816053511705684 0.46555183946488293 159 +ticlopidine bromocriptine 0.6604141113255912 0.33234337196289937 0.3280707393626919 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.36789297658862874 0.6454849498327759 0.4650501672240802 160 +loperamide verteporfin 0.7659002348322361 0.6273415427625415 0.13855869206969462 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6421404682274248 0.13377926421404682 0.4642140468227425 161 +thiostrepton duloxetine 0.6544508347786696 0.3108820598683365 0.3435687749103331 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.34448160535117056 0.68561872909699 0.46387959866220735 162 +y-26763 duloxetine 0.6725184723553764 0.36881423663229673 0.3037042357230797 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_3_computational_hit Tier_4_not_prioritized True False 0.4013377926421405 0.5719063545150501 0.4610367892976588 163 +bibx-1382 pd-0325901 0.6955630535828984 0.4238530154458232 0.27171003813707517 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.451505016722408 0.4782608695652174 0.4608695652173913 164 +loperamide nvp-tae684 0.7797068043885427 0.6708782555106731 0.10882854887786952 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6655518394648829 0.0802675585284281 0.4607023411371237 165 +thiostrepton ambroxol 0.6400946464892181 0.27653586654554296 0.36355877994367514 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.3010033444816054 0.7391304347826086 0.45434782608695645 166 +aminopentamide glycocholic-acid 0.6343537478870342 0.2548451416031828 0.37950860628385147 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.27759197324414714 0.7792642140468228 0.45317725752508364 167 +ticlopidine pd-0325901 0.6538970002919318 0.3177904746336271 0.3361065256583047 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3377926421404682 0.6622073578595318 0.45133779264214047 168 +wz-4002 verteporfin 0.7889592154210227 0.7375373790679973 0.05142183635302533 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.6822742474916388 0.020066889632107024 0.4505016722408027 169 +bibx-1382 wz-4002 0.7571377414814566 0.6325160370260062 0.1246217044554504 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6254180602006689 0.11036789297658862 0.44515050167224085 170 +pre-084 glycocholic-acid 0.6787637482500738 0.3993647181547232 0.2793990300953506 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.411371237458194 0.5050167224080268 0.44414715719063547 171 +y-26763 ambroxol 0.6581622840659249 0.35150033667949687 0.30666194738642805 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_3_computational_hit Tier_4_not_prioritized True False 0.3612040133779264 0.5919732441471572 0.4419732441471572 172 +thiostrepton tubocurarine 0.6224026075150404 0.24127142567424084 0.3811311818407995 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.2508361204013378 0.7892976588628763 0.43929765886287625 173 +aminopentamide pd-184352 0.6106388803519722 0.21865049340126538 0.3919883869507068 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.22742474916387959 0.8193979933110368 0.4346153846153846 174 +thiostrepton atorvastatin 0.6385301208744447 0.29587360214264624 0.3426565187317985 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.2976588628762542 0.6789297658862876 0.43110367892976587 175 +etomidate wz-4002 0.7629893126450331 0.7054298154026684 0.057559497242364754 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6354515050167224 0.033444816053511704 0.42474916387959866 176 +ticlopidine wz-4002 0.7154716881904899 0.5264534962138102 0.18901819197667968 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5117056856187291 0.2508361204013378 0.42040133779264216 177 +y-26763 tubocurarine 0.6404702450917472 0.3162358958081948 0.32423434928355244 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_3_computational_hit Tier_4_not_prioritized True False 0.30434782608695654 0.6321070234113713 0.4190635451505017 178 +pre-084 pd-184352 0.6550488807150118 0.36317006995280576 0.291878810762206 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.3511705685618729 0.5351170568561873 0.41555183946488294 179 +etomidate bromocriptine 0.7079317357801345 0.5113196911517575 0.196612044628377 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.49498327759197325 0.26755852842809363 0.4153846153846154 180 +prednisolone-acetate bromocriptine 0.6729444238331376 0.4162922051822072 0.25665221865093035 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.40468227424749165 0.43478260869565216 0.41521739130434787 181 +y-26763 atorvastatin 0.6565977584511513 0.3708380722766002 0.2857596861745511 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_3_computational_hit Tier_4_not_prioritized True False 0.35785953177257523 0.5183946488294314 0.4140468227424749 182 +prednisolone-acetate pd-0325901 0.666427312799478 0.40173930785293493 0.26468800494654304 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3879598662207358 0.451505016722408 0.4102006688963211 183 +etomidate pd-0325901 0.7014146247464749 0.4967667938224851 0.20464783092398975 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.46488294314381273 0.2842809364548495 0.4016722408026756 184 +geldanamycin glycocholic-acid 0.7019916990594495 0.5058375600548017 0.19615413900464773 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.47157190635451507 0.2608695652173913 0.3978260869565217 185 +ag-490 glycocholic-acid 0.5904600827821663 0.21947756487255313 0.37098251790961323 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.20066889632107024 0.7558528428093646 0.39498327759197327 186 +prochlorperazine glycocholic-acid 0.6289502565882035 0.3098850516114561 0.3190652049767474 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.26755852842809363 0.6254180602006689 0.39280936454849497 187 +arcyriaflavin-a nvp-tae684 0.7338630110431934 0.6303676216500913 0.1034953893931021 0.25139682919585277 0.135857936926186 0.176811108055214 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5551839464882943 0.07357859531772576 0.3866220735785953 188 +prednisolone-acetate wz-4002 0.7280020006980362 0.610402329433118 0.11759967126491822 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5418060200668896 0.0903010033444816 0.38377926421404684 189 +arcyriaflavin-a verteporfin 0.7200564414868871 0.5868309089019599 0.1332255325849272 0.25139682919585277 0.135857936926186 0.176811108055214 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5250836120401338 0.12040133779264214 0.3834448160535117 190 +nu-7026 bromocriptine 0.6414643342196498 0.3566813161180887 0.2847830181015611 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3110367892976589 0.5150501672240803 0.38244147157190633 191 +nu-7026 pd-0325901 0.6349472231859903 0.34212841878881645 0.29281880439717384 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2842809364548495 0.5384615384615384 0.37324414715719056 192 +geldanamycin pd-184352 0.6782768315243874 0.46964291185288437 0.20863391967150308 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.4080267558528428 0.30434782608695654 0.3717391304347826 193 +prochlorperazine pd-184352 0.6052353890531414 0.2736904034095387 0.33154498564360274 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.21739130434782608 0.6555183946488294 0.37073578595317724 194 +aminopentamide tyrphostin-1 0.6598297565258922 0.4247262345789562 0.23510352194693596 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.36454849498327757 0.38127090301003347 0.37040133779264217 195 +ag-490 pd-184352 0.5667452152471042 0.1944528978820595 0.3722923173650447 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.15384615384615385 0.7658862876254181 0.36806020066889633 196 +pre-084 tyrphostin-1 0.7042397568889316 0.5692458111304965 0.13499394575843504 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.4916387959866221 0.12709030100334448 0.3640468227424749 197 +emf-sumo1-10 bromocriptine 0.5823881208752504 0.24479462757673387 0.3375934932985165 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.19063545150501673 0.6755852842809364 0.3603678929765886 198 +geldanamycin tyrphostin-1 0.7274677076983074 0.6757186530305752 0.051749054667732164 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True False 0.5384615384615384 0.026755852842809364 0.3593645484949832 199 +bibx-1382 nvp-tae684 0.6979823764820123 0.5516689788653617 0.14631339761665063 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.46153846153846156 0.15384615384615385 0.3538461538461539 200 +emf-sumo1-10 pd-0325901 0.5758710098415908 0.2302417302474616 0.34562927959412915 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.16722408026755853 0.6956521739130435 0.3521739130434782 201 +nu-7026 wz-4002 0.6965219110845484 0.5507914403689995 0.1457304707155489 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.45819397993311034 0.1505016722408027 0.3505016722408027 202 +bibx-1382 verteporfin 0.684175806925706 0.5081322661172302 0.17604354080847584 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.4214046822742475 0.21739130434782608 0.35000000000000003 203 +loperamide glycocholic-acid 0.6659541847775616 0.4645778405376606 0.20137634423990103 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.38461538461538464 0.27759197324414714 0.3471571906354515 204 +aminopentamide ambroxol 0.5817217333685784 0.2552227861957536 0.32649894717282474 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.18394648829431437 0.6421404682274248 0.34431438127090297 205 +ticlopidine verteporfin 0.6425097536347393 0.40206972530503415 0.24044002832970512 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.3177257525083612 0.391304347826087 0.34347826086956523 206 +aminopentamide duloxetine 0.59607792165803 0.28956897951854715 0.3065089421394828 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.21070234113712374 0.5819397993311036 0.34063545150501673 207 +ticlopidine nvp-tae684 0.6563163231910458 0.44560643805316574 0.21070988513788008 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.35451505016722407 0.3076923076923077 0.33812709030100335 208 +wz-4002 glycocholic-acid 0.689013165366348 0.5420852666887057 0.14692789867764233 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.431438127090301 0.1605351170568562 0.3366220735785953 209 +aminopentamide tubocurarine 0.5640296943944006 0.21995834532445152 0.34407134906994913 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.14046822742474915 0.6923076923076923 0.3336120401337792 210 +prednisolone-acetate glycocholic-acid 0.555094016087611 0.20617386713875324 0.34892014894885776 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.13043478260869565 0.705685618729097 0.3317725752508361 211 +wz-4002 tyrphostin-1 0.7144891740052058 0.7446547698188899 -0.030165595813684054 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.5083612040133779 0.0033444816053511705 0.3316053511705686 212 +etomidate nvp-tae684 0.7038339476455888 0.6245827572420237 0.0792511904035651 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4816053511705686 0.043478260869565216 0.32826086956521744 213 +aminopentamide atorvastatin 0.5801572077538049 0.27456052179285695 0.3055966859609479 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.17725752508361203 0.5785953177257525 0.3177257525083612 214 +loperamide pd-184352 0.6422393172424995 0.42838319233574323 0.21385612490675626 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.31438127090301005 0.31438127090301005 0.31438127090301005 215 +etomidate verteporfin 0.6900273780892825 0.5810460444938923 0.1089813335953902 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.43812709030100333 0.08361204013377926 0.3140468227424749 216 +prednisolone-acetate nvp-tae684 0.6688466356985922 0.5295552712724736 0.13929136442611856 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.39464882943143814 0.14046822742474915 0.305685618729097 217 +pre-084 duloxetine 0.6404879220210695 0.43408855607008756 0.20639936595098196 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.3076923076923077 0.29431438127090304 0.3030100334448161 218 +prednisolone-acetate verteporfin 0.6550400661422856 0.48601855852434195 0.16902150761794366 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.34782608695652173 0.21070234113712374 0.29983277591973245 219 +loperamide tyrphostin-1 0.6914301934164194 0.6344589335134341 0.05697125990298535 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.44481605351170567 0.030100334448160536 0.29966555183946486 220 +prochlorperazine tyrphostin-1 0.6544262652270614 0.4797661445872295 0.17466012063983188 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True True 0.3411371237458194 0.2140468227424749 0.2966555183946488 221 +pre-084 ambroxol 0.6261317337316179 0.399742362747294 0.22638937098432388 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2608695652173913 0.35451505016722407 0.2936454849498328 222 +bibx-1382 glycocholic-acid 0.5842297568710314 0.31571589067341793 0.26851386619761347 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1939799331103679 0.47491638795986624 0.2923076923076923 223 +wz-4002 pd-184352 0.665298297831286 0.538579028641199 0.12671926919008702 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.38127090301003347 0.11371237458193979 0.2876254180602007 224 +emf-sumo1-10 wz-4002 0.637445697740149 0.43890475182764466 0.19854094591250437 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.29431438127090304 0.27424749163879597 0.28729096989966557 225 +pre-084 tubocurarine 0.6084396947574402 0.36447792187599193 0.24396177288144827 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.22073578595317725 0.39464882943143814 0.28160535117056856 226 +geldanamycin duloxetine 0.6637158728304451 0.5405613979701662 0.12315447486027886 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.3745819397993311 0.10702341137123746 0.2809364548494983 227 +ag-490 ambroxol 0.5378280682637104 0.23102519067654775 0.3068028775871627 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.10702341137123746 0.5953177257525084 0.27792642140468227 228 +prochlorperazine duloxetine 0.5906744303591992 0.34460888952682045 0.24606554083237875 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.2040133779264214 0.411371237458194 0.2765886287625418 229 +ag-490 tubocurarine 0.5201360292895327 0.19576074980524566 0.32437527948428707 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0802675585284281 0.6354515050167224 0.2745819397993311 230 +emf-sumo1-10 glycocholic-acid 0.4645377131297238 0.10148778752172533 0.3630499256079985 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.023411371237458192 0.7357859531772575 0.272742474916388 231 +prochlorperazine ambroxol 0.5763182420697477 0.31026269620402697 0.2660555458657207 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.1705685618729097 0.45819397993311034 0.27123745819397993 232 +ticlopidine glycocholic-acid 0.5425637035800647 0.23930602308015328 0.3032576804999114 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.11036789297658862 0.568561872909699 0.27073578595317727 233 +pre-084 atorvastatin 0.6245672081168445 0.41908009834439736 0.20548710977244716 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.25752508361204013 0.2909698996655518 0.2692307692307692 234 +ag-490 tyrphostin-1 0.6159360914210241 0.40052863905975034 0.2154074523612738 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.2408026755852843 0.3210702341137124 0.2688963210702341 235 +geldanamycin ambroxol 0.6493596845409936 0.5062152046473726 0.143144479893621 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.3311036789297659 0.14715719063545152 0.26672240802675584 236 +ag-490 duloxetine 0.552184256553162 0.2653713839993413 0.28681287255382065 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.12709030100334448 0.5250836120401338 0.2663879598662207 237 +prochlorperazine tubocurarine 0.55862620309557 0.2749982553327249 0.2836279477628451 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.13377926421404682 0.5083612040133779 0.26488294314381267 238 +ticlopidine pd-184352 0.5188488360450026 0.20311137487823586 0.3157374611667668 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.07357859531772576 0.6153846153846154 0.26321070234113714 239 +nu-7026 nvp-tae684 0.6373665460851043 0.46994438220835505 0.1674221638767493 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2909698996655518 0.2040133779264214 0.26053511705685617 240 +nu-7026 verteporfin 0.6235599765287978 0.42640766946022346 0.19715230706857434 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.25418060200668896 0.2709030100334448 0.2600334448160535 241 +arcyriaflavin-a glycocholic-acid 0.6201103914322124 0.42406720667707887 0.1960431847551335 0.25139682919585277 0.135857936926186 0.176811108055214 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.24749163879598662 0.25752508361204013 0.25100334448160533 242 +ag-490 atorvastatin 0.536263542648937 0.2503629262736511 0.28590061637528597 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.10033444816053512 0.5217391304347826 0.2478260869565217 243 +prochlorperazine atorvastatin 0.5747537164549742 0.3296004318011303 0.2451532846538439 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.16387959866220736 0.4013377926421405 0.24698996655518396 244 +geldanamycin atorvastatin 0.6477951589262201 0.5255529402444759 0.12224221868174423 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.32441471571906355 0.10033444816053512 0.2459866220735786 245 +arcyriaflavin-a pd-184352 0.5963955238971503 0.38787255847516144 0.2085229654219889 0.25139682919585277 0.135857936926186 0.176811108055214 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2140468227424749 0.3010033444816054 0.24448160535117058 246 +geldanamycin tubocurarine 0.6316676455668159 0.47095076377607054 0.16071688179074534 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.27424749163879597 0.18729096989966554 0.24381270903010033 247 +etomidate glycocholic-acid 0.5900813280346078 0.37400809554974485 0.21607323248486293 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.19732441471571907 0.32441471571906355 0.24180602006688962 248 +emf-sumo1-10 verteporfin 0.5644837631843984 0.31452098091886865 0.24996278226552976 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.14381270903010032 0.4214046822742475 0.24096989966555182 249 +bibx-1382 pd-184352 0.5605148893359693 0.3091739156904319 0.25134097364553737 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.13712374581939799 0.4280936454849498 0.2389632107023411 250 +emf-sumo1-10 pd-184352 0.4408228455946618 0.11556263049207037 0.3252602151025914 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.016722408026755852 0.6387959866220736 0.23444816053511705 251 +emf-sumo1-10 nvp-tae684 0.578290332740705 0.35805769366700024 0.22023263907370472 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.17391304347826086 0.33444816053511706 0.23010033444816053 252 +loperamide duloxetine 0.6276783585485572 0.480896645876032 0.14678171267252527 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.26421404682274247 0.15719063545150502 0.22675585284280936 253 +wz-4002 duloxetine 0.6507373391373438 0.6094975147584807 0.04123982437886309 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.33444816053511706 0.016722408026755852 0.22324414715719063 254 +arcyriaflavin-a tyrphostin-1 0.6455864000710703 0.5939482996528522 0.051638100418218036 0.25139682919585277 0.135857936926186 0.176811108055214 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.3210702341137124 0.023411371237458192 0.21688963210702342 255 +loperamide ambroxol 0.6133221702591057 0.4649554851302315 0.14836668512887424 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.23411371237458195 0.16722408026755853 0.21070234113712374 256 +nu-7026 glycocholic-acid 0.5236139264741232 0.26364396723534256 0.25996995923878063 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.08361204013377926 0.44481605351170567 0.2100334448160535 257 +loperamide tubocurarine 0.595630131284928 0.42969104425892946 0.16593908702599858 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.20735785953177258 0.20066889632107024 0.20501672240802676 258 +nu-7026 pd-184352 0.49989905893906117 0.2274493190334252 0.272449739905636 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.05351170568561873 0.48494983277591974 0.20451505016722407 259 +wz-4002 ambroxol 0.6363811508478922 0.5751513214356871 0.061229829412205006 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.28762541806020064 0.03678929765886288 0.19983277591973245 260 +prednisolone-acetate pd-184352 0.531379148552549 0.2870602080975437 0.2443189404550053 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0903010033444816 0.3979933110367893 0.1979933110367893 261 +loperamide atorvastatin 0.6117576446443322 0.4842932207273348 0.12746442391699742 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.23076923076923078 0.11705685618729098 0.19096989966555186 262 +wz-4002 atorvastatin 0.6348166252331188 0.5944890570327905 0.040327568200328234 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2809364548494983 0.013377926421404682 0.18729096989966554 263 +ticlopidine tubocurarine 0.4722396500874311 0.20441922680142205 0.267820423286009 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.033444816053511704 0.47157190635451507 0.18678929765886287 264 +ticlopidine ambroxol 0.4899316890616088 0.23968366767272414 0.25024802138888463 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.046822742474916385 0.42474916387959866 0.17909698996655515 265 +etomidate pd-184352 0.5663664604995458 0.382087694067094 0.18427876643245178 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1505016722408027 0.23076923076923078 0.17859531772575252 266 +emf-sumo1-10 tubocurarine 0.3942136596370902 0.11687048241525654 0.27734317722183366 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0033444816053511705 0.49498327759197325 0.17541806020066888 267 +wz-4002 tubocurarine 0.6186891118737144 0.539886880564385 0.0788022313093294 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.24414715719063546 0.04013377926421405 0.17274247491638794 268 +ticlopidine duloxetine 0.5042878773510603 0.2740298609955177 0.2302580163555426 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.06354515050167224 0.3745819397993311 0.17240802675585284 269 +bibx-1382 tyrphostin-1 0.6097057655098891 0.5152496568681226 0.09445610864176646 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.22408026755852842 0.06020066889632107 0.16672240802675584 270 +ticlopidine tyrphostin-1 0.5680397122189225 0.40918711605592667 0.1588525961629958 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.1605351170568562 0.17725752508361203 0.16638795986622074 271 +emf-sumo1-10 ambroxol 0.4119056986112679 0.15213492328655864 0.25977077532470927 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.010033444816053512 0.4414715719063545 0.16103678929765883 272 +ticlopidine atorvastatin 0.4883671634468354 0.2590214032698275 0.22934576017700792 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.043478260869565216 0.3712374581939799 0.15819397993311035 273 +arcyriaflavin-a duloxetine 0.5818345652032081 0.45879104459244324 0.12304352061076484 0.25139682919585277 0.135857936926186 0.176811108055214 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.18729096989966554 0.10367892976588629 0.15802675585284282 274 +etomidate tyrphostin-1 0.6155573366734656 0.5881634352447848 0.02739390142868081 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.23745819397993312 0.010033444816053512 0.15785953177257525 275 +arcyriaflavin-a ambroxol 0.5674783769137565 0.4244448512696497 0.14303352564410676 0.25139682919585277 0.135857936926186 0.176811108055214 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.15719063545150502 0.14381270903010032 0.15250836120401337 276 +emf-sumo1-10 duloxetine 0.4262618869007195 0.18648111660935218 0.2397807702913673 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.013377926421404682 0.3879598662207358 0.14448160535117058 277 +bibx-1382 duloxetine 0.545953930642027 0.38009240180771375 0.16586152883431327 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.11371237458193979 0.19732441471571907 0.14297658862876256 278 +bibx-1382 ambroxol 0.5315977423525755 0.3457462084849201 0.1858515338676554 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.09364548494983277 0.23411371237458195 0.14280936454849497 279 +arcyriaflavin-a tubocurarine 0.5497863379395789 0.3891804103983476 0.16060592754123126 0.25139682919585277 0.135857936926186 0.176811108055214 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.12040133779264214 0.18394648829431437 0.14264214046822743 280 +bibx-1382 tubocurarine 0.5139057033783977 0.31048176761361806 0.20342393576477963 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.06688963210702341 0.2809364548494983 0.14180602006688964 281 +emf-sumo1-10 atorvastatin 0.41034117299649453 0.17147265888366198 0.23886851411283255 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.006688963210702341 0.38461538461538464 0.13896321070234113 282 +prednisolone-acetate tyrphostin-1 0.5805700247264688 0.49313594927523446 0.08743407545123433 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.1806020066889632 0.056856187290969896 0.13729096989966555 283 +nu-7026 tubocurarine 0.45328987298148965 0.22875717095661136 0.2245327020248783 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.020066889632107024 0.34448160535117056 0.13361204013377925 284 +arcyriaflavin-a atorvastatin 0.565913851298983 0.4437825868667531 0.12213126443222988 0.25139682919585277 0.135857936926186 0.176811108055214 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.14715719063545152 0.09698996655518395 0.12959866220735788 285 +nu-7026 ambroxol 0.47098191195566735 0.26402161182791345 0.2069603001277539 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.030100334448160536 0.2976588628762542 0.12374581939799331 286 +bibx-1382 atorvastatin 0.5300332167378019 0.3650839440820235 0.1649492726557784 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.08695652173913043 0.19063545150501673 0.12324414715719065 287 +prednisolone-acetate tubocurarine 0.4847699625949774 0.28836806002072984 0.19640190257424756 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.03678929765886288 0.26421404682274247 0.11638795986622073 288 +prednisolone-acetate ambroxol 0.5024620015691551 0.323632500892032 0.1788295006771231 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.06020066889632107 0.22073578595317725 0.11638795986622072 289 +nu-7026 duloxetine 0.4853381002451189 0.298367805150707 0.18697029509441193 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.04013377926421405 0.24414715719063546 0.11153846153846153 290 +nu-7026 tyrphostin-1 0.5490899351129811 0.433525060211116 0.11556487490186512 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.11705685618729098 0.08695652173913043 0.10652173913043478 291 +prednisolone-acetate duloxetine 0.5168181898586066 0.35797869421482553 0.15883949564378108 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.07023411371237458 0.17391304347826086 0.10652173913043478 291 +emf-sumo1-10 tyrphostin-1 0.4900137217685816 0.32163837166976117 0.16837535009882043 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.05016722408026756 0.20735785953177258 0.10518394648829432 293 +etomidate duloxetine 0.5518055018056035 0.4530061801843758 0.09879932162122773 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.12374581939799331 0.06688963210702341 0.10384615384615385 294 +nu-7026 atorvastatin 0.46941738634089386 0.2833593474250168 0.18605803891587708 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.026755852842809364 0.23745819397993312 0.10050167224080267 295 +etomidate ambroxol 0.5374493135161519 0.41865998686158223 0.11878932665456965 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.10367892976588629 0.09364548494983277 0.10016722408026756 296 +prednisolone-acetate atorvastatin 0.5008974759543816 0.34297023648913527 0.15792723946524634 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.056856187290969896 0.1705685618729097 0.09665551839464882 297 +etomidate tubocurarine 0.5197572745419742 0.38339554599028003 0.13636172855169415 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.07692307692307693 0.13043478260869565 0.09565217391304348 298 +etomidate atorvastatin 0.5358847879013784 0.43799772245868557 0.09788706544269282 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.09698996655518395 0.06354515050167224 0.08528428093645486 299 diff --git a/data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/ezetimibe_verteporfin_weight_sensitivity.tsv b/data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/ezetimibe_verteporfin_weight_sensitivity.tsv new file mode 100644 index 0000000..aeb691b --- /dev/null +++ b/data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/ezetimibe_verteporfin_weight_sensitivity.tsv @@ -0,0 +1,28 @@ +early_retention_weight resolver_weight penalty_weight forward_score order_advantage basin_switch_index rank n_pairs +0.25 0.35 1.0 0.7246761919671876 0.4179434199507038 0.844314381270903 36 299 +0.25 0.35 1.5 0.7246761919671876 0.4179434199507038 0.84314381270903 37 299 +0.25 0.35 2.0 0.7246761919671876 0.4179434199507038 0.8419732441471572 37 299 +0.25 0.5 1.0 0.9043628719842267 0.47952845282409157 0.8745819397993311 30 299 +0.25 0.5 1.5 0.9043628719842267 0.47952845282409157 0.8745819397993311 29 299 +0.25 0.5 2.0 0.9043628719842267 0.47952845282409157 0.8745819397993311 28 299 +0.25 0.65 1.0 1.084049552001266 0.5411134856974796 0.8929765886287626 25 299 +0.25 0.65 1.5 1.084049552001266 0.5411134856974796 0.8929765886287626 25 299 +0.25 0.65 2.0 1.084049552001266 0.5411134856974796 0.8929765886287626 25 299 +0.5 0.35 1.0 0.7126256437092605 0.3265284166464375 0.8093645484949834 37 299 +0.5 0.35 1.5 0.7126256437092605 0.3265284166464375 0.8081939799331104 37 299 +0.5 0.35 2.0 0.7126256437092605 0.3265284166464375 0.8058528428093645 38 299 +0.5 0.5 1.0 0.8923123237262998 0.3881134495198255 0.8724080267558529 24 299 +0.5 0.5 1.5 0.8923123237262998 0.3881134495198255 0.8724080267558529 24 299 +0.5 0.5 2.0 0.8923123237262998 0.3881134495198255 0.8712374581939799 24 299 +0.5 0.65 1.0 1.071999003743339 0.4496984823932133 0.8874581939799331 23 299 +0.5 0.65 1.5 1.071999003743339 0.4496984823932133 0.8862876254180603 23 299 +0.5 0.65 2.0 1.071999003743339 0.4496984823932133 0.8851170568561874 23 299 +0.75 0.35 1.0 0.7005750954513333 0.23511341334217117 0.7570234113712374 46 299 +0.75 0.35 1.5 0.7005750954513333 0.23511341334217117 0.7546822742474917 46 299 +0.75 0.35 2.0 0.7005750954513333 0.23511341334217117 0.7523411371237458 46 299 +0.75 0.5 1.0 0.8802617754683726 0.2966984462155591 0.8397993311036789 27 299 +0.75 0.5 1.5 0.8802617754683726 0.2966984462155591 0.8362876254180602 28 299 +0.75 0.5 2.0 0.8802617754683726 0.2966984462155591 0.8351170568561873 28 299 +0.75 0.65 1.0 1.0599484554854117 0.35828347908894687 0.8854515050167224 20 299 +0.75 0.65 1.5 1.0599484554854117 0.35828347908894687 0.8842809364548496 20 299 +0.75 0.65 2.0 1.0599484554854117 0.35828347908894687 0.8819397993311038 20 299 diff --git a/data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/sequential_basin_switch_summary.json b/data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/sequential_basin_switch_summary.json new file mode 100644 index 0000000..ac1a79c --- /dev/null +++ b/data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/sequential_basin_switch_summary.json @@ -0,0 +1,35 @@ +{ + "n_eligible_compounds": 394, + "n_early_primers": 20, + "n_late_suppressors": 15, + "n_ordered_pairs": 299, + "lead_pair": "ezetimibe -> verteporfin", + "lead_pair_metrics": { + "early_compound": "ezetimibe", + "late_compound": "verteporfin", + "forward_score": 0.8923123237262998, + "reverse_score": 0.5041988742064742, + "order_advantage": 0.3881134495198255, + "early_mean_resolver": 0.5361593619787267, + "early_resolver_floor": 0.2945428660937718, + "early_retention": -0.0482021930317084, + "late_retention": 0.3174578201853567, + "late_q25_retention": 0.1837441553879115, + "late_resolver_floor": 0.0395371671766042, + "early_tier": "Tier_4_not_prioritized", + "late_tier": "Tier_1_mechanistic_probe", + "both_named": true, + "both_hard_gate": false, + "forward_percentile": 0.9063545150501672, + "order_percentile": 0.8093645484949833, + "basin_switch_index": 0.8724080267558529, + "basin_switch_rank": 24 + }, + "weight_sensitivity": { + "median_rank": 28.0, + "best_rank": 20, + "worst_rank": 46, + "n_schemes": 27 + }, + "claim": "A prime-then-switch hypothesis with a strong computed direction advantage; designed for direct equal-exposure order testing." +} diff --git a/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE295293_exact_phase_tests.tsv b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE295293_exact_phase_tests.tsv new file mode 100644 index 0000000..06dd9f7 --- /dev/null +++ b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE295293_exact_phase_tests.tsv @@ -0,0 +1,10 @@ +outcome contrast effect exact_two_sided_p exact_directional_p n_assignments +resolver_axis progression 1.8517825485074735 0.004164187983343248 0.002379535990481856 1680 +resolver_axis withdrawal -0.4113883868762583 0.5823914336704342 0.2914931588340274 1680 +resolver_axis residual 1.4403941616312153 0.042236763831052945 0.021415823914336704 1680 +lock_axis progression 1.4121560803037632 0.006543723973825104 0.003569303985722784 1680 +lock_axis withdrawal -0.6569694957746913 0.32540154669839383 0.16299821534800712 1680 +lock_axis residual 0.7551865845290717 0.2552052349791791 0.12790005948839978 1680 +control_imbalance progression -0.3108628568559357 0.3075550267697799 0.15407495538370017 1680 +control_imbalance withdrawal -0.17365206743339404 0.5728732897085068 0.2867340868530637 1680 +control_imbalance residual -0.4845149242893297 0.06841165972635337 0.034503271861986914 1680 diff --git a/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE295293_mouse_phase_scores.tsv b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE295293_mouse_phase_scores.tsv new file mode 100644 index 0000000..9575b58 --- /dev/null +++ b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE295293_mouse_phase_scores.tsv @@ -0,0 +1,10 @@ +sample condition HSC_retention feedback_core TGF_latch antiproteolytic_brake protease_potential Endo_resolver LAM_resolver clearance_inefficiency lock_axis resolver_axis control_imbalance +GSM8944960 control -1.345995655403353 -1.3322968151556474 -1.2211849363932057 -0.7052707825829547 -1.3739025148961808 -1.5255884504427841 -0.7417945976285544 0.5807965598257667 -0.9524769967434896 -1.451889528999471 0.3531379881677499 +GSM8944961 control -1.0609571590348146 -1.4891233204584826 -1.3588285532774598 -1.6952251794063882 -0.8696181316269348 -1.1261956697181543 -0.8442914138971437 -1.188277872356866 -1.5051809324642 -1.2579831153458279 -0.17479525277891297 +GSM8944962 control -0.5590708790863852 -0.04500866506358334 -0.21857352806572342 0.381408738125549 -1.157441577896882 0.38266147595554906 -1.3221427344377543 1.7047369160765582 0.2903152643748548 -0.5823040657933898 0.6170350457564285 +GSM8944963 fibrosis 0.6704804425358072 0.8241319630026431 0.8690568708454823 0.8733998409256309 1.2100196523494406 0.4320092372989994 0.855279095400027 -0.19723417850720382 0.6204682170639029 0.8160501037863274 -0.13829727837868552 +GSM8944964 fibrosis 0.5614163965850142 0.6974456407924112 1.214510150281397 0.5380455492162894 0.6841948820885797 0.4595743047243846 0.6449879391990025 -0.056469149858308754 0.6908473103386815 0.7019034767074173 -0.00781789021325969 +GSM8944965 fibrosis 0.7448230256989853 1.1108893195871863 0.9360408924883048 0.7572922883528874 1.0280983071446106 0.485977503011381 0.6868055982745728 -0.14863777917863508 0.7578100486758701 0.745217354889987 0.008904379169403655 +GSM8944966 regression 0.3410309510748916 0.12440285216613108 -0.1488337051894603 -0.08068151828388169 0.3175035142244395 0.5941969611222547 0.6404388114227156 -0.4378024179912378 -0.03704838129516054 0.786089348052929 -0.5820462702725311 +GSM8944967 regression 0.19298538935909457 -0.11540380692829486 -0.10574824735008433 -0.06949083464798456 0.11728505821763457 0.07495472490067735 -0.09124698734122662 -0.2111692486673683 -0.06694429909071264 -0.008800139396924402 -0.0411141296058712 +GSM8944968 regression 0.45528748827076027 0.22496283205763726 0.03356105666075737 0.0005218983008468403 0.043860810395294235 0.22240991314768915 0.17196428900836214 -0.04594282934270515 0.20220976914025351 0.2517165660989521 -0.03500659184432131 diff --git a/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE305331_cross_etiology_phase_trajectories.tsv b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE305331_cross_etiology_phase_trajectories.tsv new file mode 100644 index 0000000..2f7b6d1 --- /dev/null +++ b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE305331_cross_etiology_phase_trajectories.tsv @@ -0,0 +1,8 @@ +sample etiology timepoint week Endo4_WNT_resolver HSC_SFRP_brake HSC_pathogenic_retention LAM_resolver resolver_proxy lock_proxy +GSM9168817 CCl4 peak 0 0.0555967235494823 0.0383744187973515 0.0448371180383815 0.1608412398217633 0.30827984679755643 -1.2041259367288915 +GSM9168818 CCl4 2wk 2 0.0671932414639214 0.0286519660221869 0.101105386080708 0.146488879874782 0.2662158195244718 0.5981387055786985 +GSM9168819 CCl4 6wk 6 0.0438334122924769 0.0173179652145826 0.0659599467032657 0.0840776229720046 -1.0429583861320035 -0.527564731404328 +GSM9168820 FAT_MASH peak 0 0.0545920695341909 0.0356093929797824 0.0966510655269306 0.2363930747156123 1.4461370289505413 0.4554674502001219 +GSM9168821 FAT_MASH 2wk 2 0.0717045547887044 0.0328661150238461 0.0956331560490578 0.1755755286236793 0.7790411470646168 0.42286395404026234 +GSM9168822 FAT_MASH 6wk 6 0.0537378420714683 0.017340680622555 0.1276877989139002 0.0520331029516959 -1.380895520678218 1.4495696172329853 +GSM9168823 Untreated baseline -1 0.0774370694322981 0.0076386314153605 0.0451423606583156 0.0941818155767286 -0.3758199355269681 -1.1943490589188486 diff --git a/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/mouse_module_mapping.tsv b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/mouse_module_mapping.tsv new file mode 100644 index 0000000..33fd642 --- /dev/null +++ b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/mouse_module_mapping.tsv @@ -0,0 +1,8 @@ +module cell_type requested present genes +HSC_retention HSC_Mesenchymal 11 11 Itgb5;Gas7;Spon1;Svep1;Pdgfra;Lama2;Epha3;Dpysl3;Ltbp2;Efemp1;Serpine1 +feedback_core HSC_Mesenchymal 4 4 Serpine1;Spon1;Gas7;Ltbp2 +TGF_latch HSC_Mesenchymal 8 7 Tgfb1;Tgfbr1;Tgfbr2;Smad3;Smad7;Ccn2;Thbs1 +antiproteolytic_brake HSC_Mesenchymal 4 4 Serpine1;Timp1;Timp2;Thbs1 +protease_potential Myeloid 5 5 Plau;Plat;Mmp2;Mmp9;Mmp14 +Endo_resolver Endothelial 10 10 Wnt9b;Wnt7b;Vwf;Ace;Kdr;Esam;Emcn;Plvap;Klf2;Nr2f2 +LAM_resolver Myeloid 8 8 Trem2;Gpnmb;Lpl;Mmp14;Ctsb;Ctsd;Axl;Mertk diff --git a/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/mouse_phase_trajectory_summary.json b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/mouse_phase_trajectory_summary.json new file mode 100644 index 0000000..7e98924 --- /dev/null +++ b/data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/mouse_phase_trajectory_summary.json @@ -0,0 +1,103 @@ +{ + "n_replicated_mice": 9, + "geometry": { + "progression_vector": [ + 1.8517825485074735, + 1.4121560803037632 + ], + "withdrawal_vector": [ + -0.4113883868762583, + -0.6569694957746913 + ], + "return_cosine": 0.9359570143983825, + "return_angle_degrees": 20.616688658580056, + "residual_distance_ratio": 0.6983693102084559, + "control_centroid": [ + -1.0973922367128963, + -0.7224475549442783 + ], + "fibrosis_centroid": [ + 0.7543903117945772, + 0.6897085253594848 + ], + "regression_centroid": [ + 0.3430019249183189, + 0.032739029584793446 + ] + }, + "tests": [ + { + "outcome": "resolver_axis", + "contrast": "progression", + "effect": 1.8517825485074735, + "exact_two_sided_p": 0.004164187983343248, + "exact_directional_p": 0.002379535990481856, + "n_assignments": 1680 + }, + { + "outcome": "resolver_axis", + "contrast": "withdrawal", + "effect": -0.4113883868762583, + "exact_two_sided_p": 0.5823914336704342, + "exact_directional_p": 0.2914931588340274, + "n_assignments": 1680 + }, + { + "outcome": "resolver_axis", + "contrast": "residual", + "effect": 1.4403941616312153, + "exact_two_sided_p": 0.042236763831052945, + "exact_directional_p": 0.021415823914336704, + "n_assignments": 1680 + }, + { + "outcome": "lock_axis", + "contrast": "progression", + "effect": 1.4121560803037632, + "exact_two_sided_p": 0.006543723973825104, + "exact_directional_p": 0.003569303985722784, + "n_assignments": 1680 + }, + { + "outcome": "lock_axis", + "contrast": "withdrawal", + "effect": -0.6569694957746913, + "exact_two_sided_p": 0.32540154669839383, + "exact_directional_p": 0.16299821534800712, + "n_assignments": 1680 + }, + { + "outcome": "lock_axis", + "contrast": "residual", + "effect": 0.7551865845290717, + "exact_two_sided_p": 0.2552052349791791, + "exact_directional_p": 0.12790005948839978, + "n_assignments": 1680 + }, + { + "outcome": "control_imbalance", + "contrast": "progression", + "effect": -0.3108628568559357, + "exact_two_sided_p": 0.3075550267697799, + "exact_directional_p": 0.15407495538370017, + "n_assignments": 1680 + }, + { + "outcome": "control_imbalance", + "contrast": "withdrawal", + "effect": -0.17365206743339404, + "exact_two_sided_p": 0.5728732897085068, + "exact_directional_p": 0.2867340868530637, + "n_assignments": 1680 + }, + { + "outcome": "control_imbalance", + "contrast": "residual", + "effect": -0.4845149242893297, + "exact_two_sided_p": 0.06841165972635337, + "exact_directional_p": 0.034503271861986914, + "n_assignments": 1680 + } + ], + "claim": "Withdrawal follows a non-reciprocal trajectory with residual displacement in resolver-lock space." +} diff --git a/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_biopsy_profiles.tsv b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_biopsy_profiles.tsv new file mode 100644 index 0000000..b034f2d --- /dev/null +++ b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_biopsy_profiles.tsv @@ -0,0 +1,166 @@ +biopsy_id patient_cluster stage_numeric distance n_spots Endothelial resolver Macrophage resolver Protease activation Antiproteolytic brake HSC retention TGF-beta 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-0.2078966792534795 -0.25562937075416364 -0.1541910828671873 -0.0008405712841140263 0.05592588514469976 +UQ_B33 UQ_P33 3.0 1 226 0.10222867878359486 0.3243541651667144 0.21921808355633118 0.41352137641339887 0.2900458107505774 0.20958204011225046 0.18354495407386834 -0.08911609992319536 +UQ_B33 UQ_P33 3.0 2 71 0.39011480815337973 0.5811981177797332 0.5213583371651062 0.8117071544437525 0.9574688599885247 0.5931448831769223 0.6985445119347166 -0.2898832115036601 +UQ_B33 UQ_P33 3.0 3 29 0.4416140234858748 0.7640527942863912 0.20709231608542897 1.079796706254359 1.73831396767218 0.40011401881536784 0.9053723268182524 -0.601821852961404 +UQ_B33 UQ_P33 3.0 4 6 -0.020492383468852182 1.4185943385185291 0.08365560006090457 1.2268628324685873 1.5411281865930186 -0.029588961614862835 0.9412285848708836 -0.4188815007787206 diff --git a/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_boundary_effect_summary.tsv b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_boundary_effect_summary.tsv new file mode 100644 index 0000000..62185f5 --- /dev/null +++ b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_boundary_effect_summary.tsv @@ -0,0 +1,8 @@ +module n_biopsies mean_shift median_shift bootstrap_ci_low bootstrap_ci_high wilcoxon_statistic p_value fdr +Endothelial resolver 33 0.3638541949910541 0.36837810773494784 0.3033498712692662 0.42577882640584763 2.0 6.984919309616089e-10 1.6298145055770874e-09 +Macrophage resolver 33 0.2541995063331348 0.24264737006077125 0.19994054318606044 0.30671972607132375 10.0 1.0011717677116394e-08 1.4016404747962952e-08 +Protease activation 33 0.13374393322935604 0.1294291845076384 0.08467243286075163 0.18440296641172846 41.0 2.304092049598694e-06 2.630287781357765e-06 +Antiproteolytic brake 33 0.38298122934015044 0.34651617194685636 0.30902602993386286 0.45738940676531914 0.0 2.3283064365386963e-10 8.149072527885437e-10 +HSC retention 33 0.4082297145373421 0.36631523952731426 0.3224160989089668 0.49504407959756025 0.0 2.3283064365386963e-10 8.149072527885437e-10 +TGF-beta integrator 33 0.13882677711477873 0.11701559891038267 0.09150501977256048 0.1850203248857316 42.0 2.630287781357765e-06 2.630287781357765e-06 +Structural ECM 33 0.18598674371980287 0.15283400514493511 0.13771687150472187 0.23673067646242452 3.0 1.1641532182693481e-09 2.0372681319713593e-09 diff --git a/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_boundary_effects_by_biopsy.tsv b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_boundary_effects_by_biopsy.tsv new file mode 100644 index 0000000..6740c37 --- /dev/null +++ b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_boundary_effects_by_biopsy.tsv @@ -0,0 +1,232 @@ +biopsy_id patient_cluster stage_numeric module locked_minus_resolved fdr +UQ_B02 UQ_P02 1.0 Endothelial resolver 0.44373933371420027 1.6298145055770874e-09 +UQ_B02 UQ_P02 1.0 Macrophage resolver 0.43350034395844284 1.4016404747962952e-08 +UQ_B02 UQ_P02 1.0 Protease activation 0.1608283063094448 2.630287781357765e-06 +UQ_B02 UQ_P02 1.0 Antiproteolytic brake 0.30695017174275346 8.149072527885437e-10 +UQ_B02 UQ_P02 1.0 HSC retention 0.29226986415161277 8.149072527885437e-10 +UQ_B02 UQ_P02 1.0 TGF-beta integrator 0.05432455964032027 2.630287781357765e-06 +UQ_B02 UQ_P02 1.0 Structural ECM 0.09113218846057815 2.0372681319713593e-09 +UQ_B01 UQ_P01 3.0 Endothelial resolver 0.5915844433141189 1.6298145055770874e-09 +UQ_B01 UQ_P01 3.0 Macrophage resolver 0.19197276019522888 1.4016404747962952e-08 +UQ_B01 UQ_P01 3.0 Protease activation 0.10324276246365777 2.630287781357765e-06 +UQ_B01 UQ_P01 3.0 Antiproteolytic brake 0.3224000382339529 8.149072527885437e-10 +UQ_B01 UQ_P01 3.0 HSC retention 0.502253462887124 8.149072527885437e-10 +UQ_B01 UQ_P01 3.0 TGF-beta integrator 0.29222153198924894 2.630287781357765e-06 +UQ_B01 UQ_P01 3.0 Structural ECM 0.12952364915062367 2.0372681319713593e-09 +UQ_B04 UQ_P04 1.0 Endothelial resolver 0.3425491844758993 1.6298145055770874e-09 +UQ_B04 UQ_P04 1.0 Macrophage resolver 0.16845123592554193 1.4016404747962952e-08 +UQ_B04 UQ_P04 1.0 Protease activation 0.02655063512848162 2.630287781357765e-06 +UQ_B04 UQ_P04 1.0 Antiproteolytic brake 0.47264991327853045 8.149072527885437e-10 +UQ_B04 UQ_P04 1.0 HSC retention 0.3637444059831525 8.149072527885437e-10 +UQ_B04 UQ_P04 1.0 TGF-beta integrator 0.08495269759508511 2.630287781357765e-06 +UQ_B04 UQ_P04 1.0 Structural ECM 0.10646772440682657 2.0372681319713593e-09 +UQ_B03 UQ_P03 1.0 Endothelial resolver 0.36837810773494784 1.6298145055770874e-09 +UQ_B03 UQ_P03 1.0 Macrophage resolver 0.1211571744885502 1.4016404747962952e-08 +UQ_B03 UQ_P03 1.0 Protease activation 0.17940691428008654 2.630287781357765e-06 +UQ_B03 UQ_P03 1.0 Antiproteolytic brake 0.44202747212644256 8.149072527885437e-10 +UQ_B03 UQ_P03 1.0 HSC retention 0.25076008377590464 8.149072527885437e-10 +UQ_B03 UQ_P03 1.0 TGF-beta integrator 0.2588144761332283 2.630287781357765e-06 +UQ_B03 UQ_P03 1.0 Structural ECM 0.11727704994601545 2.0372681319713593e-09 +UQ_B07 UQ_P07 4.0 Endothelial resolver 0.41950551903758176 1.6298145055770874e-09 +UQ_B07 UQ_P07 4.0 Macrophage resolver 0.3872298122997891 1.4016404747962952e-08 +UQ_B07 UQ_P07 4.0 Protease activation 0.2636431531629237 2.630287781357765e-06 +UQ_B07 UQ_P07 4.0 Antiproteolytic brake 0.5349480127531481 8.149072527885437e-10 +UQ_B07 UQ_P07 4.0 HSC retention 0.6134471649120936 8.149072527885437e-10 +UQ_B07 UQ_P07 4.0 TGF-beta integrator 0.3279277316657728 2.630287781357765e-06 +UQ_B07 UQ_P07 4.0 Structural ECM 0.2917322765507002 2.0372681319713593e-09 +UQ_B06 UQ_P06 3.0 Endothelial resolver 0.008346734523176247 1.6298145055770874e-09 +UQ_B06 UQ_P06 3.0 Macrophage resolver 0.38980713360585556 1.4016404747962952e-08 +UQ_B06 UQ_P06 3.0 Protease activation 0.08265759793907976 2.630287781357765e-06 +UQ_B06 UQ_P06 3.0 Antiproteolytic brake 0.12358070525794652 8.149072527885437e-10 +UQ_B06 UQ_P06 3.0 HSC retention 0.34083509570447956 8.149072527885437e-10 +UQ_B06 UQ_P06 3.0 TGF-beta integrator 0.07742297020734251 2.630287781357765e-06 +UQ_B06 UQ_P06 3.0 Structural ECM 0.1921730477033651 2.0372681319713593e-09 +UQ_B05 UQ_P05 3.0 Endothelial resolver 0.5356496104712432 1.6298145055770874e-09 +UQ_B05 UQ_P05 3.0 Macrophage resolver 0.3693572002485115 1.4016404747962952e-08 +UQ_B05 UQ_P05 3.0 Protease activation 0.3876254950967592 2.630287781357765e-06 +UQ_B05 UQ_P05 3.0 Antiproteolytic brake 0.4107096534178959 8.149072527885437e-10 +UQ_B05 UQ_P05 3.0 HSC retention 0.6799107791286454 8.149072527885437e-10 +UQ_B05 UQ_P05 3.0 TGF-beta integrator 0.2017891493798472 2.630287781357765e-06 +UQ_B05 UQ_P05 3.0 Structural ECM 0.3450141573284583 2.0372681319713593e-09 +UQ_B08 UQ_P08 0.0 Endothelial resolver 0.29175789852887696 1.6298145055770874e-09 +UQ_B08 UQ_P08 0.0 Macrophage resolver -0.04994482577325257 1.4016404747962952e-08 +UQ_B08 UQ_P08 0.0 Protease activation 0.005746756301360345 2.630287781357765e-06 +UQ_B08 UQ_P08 0.0 Antiproteolytic brake 0.17664459171927982 8.149072527885437e-10 +UQ_B08 UQ_P08 0.0 HSC retention 0.10009118194060129 8.149072527885437e-10 +UQ_B08 UQ_P08 0.0 TGF-beta integrator -0.08405775895966902 2.630287781357765e-06 +UQ_B08 UQ_P08 0.0 Structural ECM 0.06054462414684969 2.0372681319713593e-09 +UQ_B10 UQ_P10 3.0 Endothelial resolver 0.46958677518247843 1.6298145055770874e-09 +UQ_B10 UQ_P10 3.0 Macrophage resolver 0.4460608169847051 1.4016404747962952e-08 +UQ_B10 UQ_P10 3.0 Protease activation -0.06301934555902972 2.630287781357765e-06 +UQ_B10 UQ_P10 3.0 Antiproteolytic brake 0.63266002741805 8.149072527885437e-10 +UQ_B10 UQ_P10 3.0 HSC retention 0.7322583910694731 8.149072527885437e-10 +UQ_B10 UQ_P10 3.0 TGF-beta integrator 0.11088702713435752 2.630287781357765e-06 +UQ_B10 UQ_P10 3.0 Structural ECM 0.223528738133538 2.0372681319713593e-09 +UQ_B09 UQ_P09 1.0 Endothelial resolver 0.4089088993730938 1.6298145055770874e-09 +UQ_B09 UQ_P09 1.0 Macrophage resolver 0.21807367518316506 1.4016404747962952e-08 +UQ_B09 UQ_P09 1.0 Protease activation 0.012687871499493894 2.630287781357765e-06 +UQ_B09 UQ_P09 1.0 Antiproteolytic brake 0.8283323620105394 8.149072527885437e-10 +UQ_B09 UQ_P09 1.0 HSC retention 0.42274802392913763 8.149072527885437e-10 +UQ_B09 UQ_P09 1.0 TGF-beta integrator 0.05159034021342688 2.630287781357765e-06 +UQ_B09 UQ_P09 1.0 Structural ECM 0.07195128821055463 2.0372681319713593e-09 +UQ_B12 UQ_P12 1.0 Endothelial resolver 0.3195279646096658 1.6298145055770874e-09 +UQ_B12 UQ_P12 1.0 Macrophage resolver 0.29762906572472947 1.4016404747962952e-08 +UQ_B12 UQ_P12 1.0 Protease activation 0.1735512616629537 2.630287781357765e-06 +UQ_B12 UQ_P12 1.0 Antiproteolytic brake 0.24276437192826142 8.149072527885437e-10 +UQ_B12 UQ_P12 1.0 HSC retention 0.1677515068769414 8.149072527885437e-10 +UQ_B12 UQ_P12 1.0 TGF-beta integrator -0.0005236845648694533 2.630287781357765e-06 +UQ_B12 UQ_P12 1.0 Structural ECM 0.05432966310146911 2.0372681319713593e-09 +UQ_B11 UQ_P11 2.0 Endothelial resolver 0.31042931531768414 1.6298145055770874e-09 +UQ_B11 UQ_P11 2.0 Macrophage resolver 0.2016186472158049 1.4016404747962952e-08 +UQ_B11 UQ_P11 2.0 Protease activation 0.30968388715529926 2.630287781357765e-06 +UQ_B11 UQ_P11 2.0 Antiproteolytic brake 0.18062538712248394 8.149072527885437e-10 +UQ_B11 UQ_P11 2.0 HSC retention 0.36631523952731426 8.149072527885437e-10 +UQ_B11 UQ_P11 2.0 TGF-beta integrator 0.12180007019415047 2.630287781357765e-06 +UQ_B11 UQ_P11 2.0 Structural ECM 0.15547669798946506 2.0372681319713593e-09 +UQ_B14 UQ_P14 1.0 Endothelial resolver 0.1633925925832927 1.6298145055770874e-09 +UQ_B14 UQ_P14 1.0 Macrophage resolver -0.0011110296357817462 1.4016404747962952e-08 +UQ_B14 UQ_P14 1.0 Protease activation 0.021544837854201193 2.630287781357765e-06 +UQ_B14 UQ_P14 1.0 Antiproteolytic brake 0.25286700811290824 8.149072527885437e-10 +UQ_B14 UQ_P14 1.0 HSC retention 0.17424203315372436 8.149072527885437e-10 +UQ_B14 UQ_P14 1.0 TGF-beta integrator -0.0067637767595120635 2.630287781357765e-06 +UQ_B14 UQ_P14 1.0 Structural ECM -0.03216077701019593 2.0372681319713593e-09 +UQ_B13 UQ_P13 4.0 Endothelial resolver 0.8402221351912051 1.6298145055770874e-09 +UQ_B13 UQ_P13 4.0 Macrophage resolver 0.20656328210407415 1.4016404747962952e-08 +UQ_B13 UQ_P13 4.0 Protease activation 0.6005643804465048 2.630287781357765e-06 +UQ_B13 UQ_P13 4.0 Antiproteolytic brake 0.5741064386492192 8.149072527885437e-10 +UQ_B13 UQ_P13 4.0 HSC retention 1.158380461618833 8.149072527885437e-10 +UQ_B13 UQ_P13 4.0 TGF-beta integrator 0.11701559891038267 2.630287781357765e-06 +UQ_B13 UQ_P13 4.0 Structural ECM 0.5825120569858232 2.0372681319713593e-09 +UQ_B16 UQ_P16 1.0 Endothelial resolver 0.5690347029680816 1.6298145055770874e-09 +UQ_B16 UQ_P16 1.0 Macrophage resolver 0.3167984923403359 1.4016404747962952e-08 +UQ_B16 UQ_P16 1.0 Protease activation 0.0008495532647787435 2.630287781357765e-06 +UQ_B16 UQ_P16 1.0 Antiproteolytic brake 0.3958367806125124 8.149072527885437e-10 +UQ_B16 UQ_P16 1.0 HSC retention 0.42338889609979163 8.149072527885437e-10 +UQ_B16 UQ_P16 1.0 TGF-beta integrator 0.02727896248111711 2.630287781357765e-06 +UQ_B16 UQ_P16 1.0 Structural ECM 0.046342576656958956 2.0372681319713593e-09 +UQ_B15 UQ_P15 1.0 Endothelial resolver 0.4662215331134446 1.6298145055770874e-09 +UQ_B15 UQ_P15 1.0 Macrophage resolver 0.26065628052563233 1.4016404747962952e-08 +UQ_B15 UQ_P15 1.0 Protease activation 0.14270230146626817 2.630287781357765e-06 +UQ_B15 UQ_P15 1.0 Antiproteolytic brake 0.0571645279324505 8.149072527885437e-10 +UQ_B15 UQ_P15 1.0 HSC retention 0.06748083149136191 8.149072527885437e-10 +UQ_B15 UQ_P15 1.0 TGF-beta integrator -0.08077014976534636 2.630287781357765e-06 +UQ_B15 UQ_P15 1.0 Structural ECM 0.03735312623735548 2.0372681319713593e-09 +UQ_B19 UQ_P19 3.0 Endothelial resolver 0.300730691946102 1.6298145055770874e-09 +UQ_B19 UQ_P19 3.0 Macrophage resolver 0.322635775666509 1.4016404747962952e-08 +UQ_B19 UQ_P19 3.0 Protease activation 0.062371391827797086 2.630287781357765e-06 +UQ_B19 UQ_P19 3.0 Antiproteolytic brake 0.3047650445161762 8.149072527885437e-10 +UQ_B19 UQ_P19 3.0 HSC retention 0.26394052148514835 8.149072527885437e-10 +UQ_B19 UQ_P19 3.0 TGF-beta integrator 0.04420069579881247 2.630287781357765e-06 +UQ_B19 UQ_P19 3.0 Structural ECM 0.2035228485965123 2.0372681319713593e-09 +UQ_B18 UQ_P18 0.0 Endothelial resolver 0.2547686177049442 1.6298145055770874e-09 +UQ_B18 UQ_P18 0.0 Macrophage resolver 0.24991550491370387 1.4016404747962952e-08 +UQ_B18 UQ_P18 0.0 Protease activation 0.12571341061841218 2.630287781357765e-06 +UQ_B18 UQ_P18 0.0 Antiproteolytic brake 0.26426284952253626 8.149072527885437e-10 +UQ_B18 UQ_P18 0.0 HSC retention 0.13896194940201914 8.149072527885437e-10 +UQ_B18 UQ_P18 0.0 TGF-beta integrator 0.21913012709139174 2.630287781357765e-06 +UQ_B18 UQ_P18 0.0 Structural ECM 0.07212266888487423 2.0372681319713593e-09 +UQ_B17 UQ_P17 0.0 Endothelial resolver 0.08847934188319752 1.6298145055770874e-09 +UQ_B17 UQ_P17 0.0 Macrophage resolver -0.025107360554537772 1.4016404747962952e-08 +UQ_B17 UQ_P17 0.0 Protease activation -0.07922358006967584 2.630287781357765e-06 +UQ_B17 UQ_P17 0.0 Antiproteolytic brake 0.46868796598647633 8.149072527885437e-10 +UQ_B17 UQ_P17 0.0 HSC retention 0.1612001570233233 8.149072527885437e-10 +UQ_B17 UQ_P17 0.0 TGF-beta integrator 0.06224776254871264 2.630287781357765e-06 +UQ_B17 UQ_P17 0.0 Structural ECM 0.07986852421206062 2.0372681319713593e-09 +UQ_B20 UQ_P20 4.0 Endothelial resolver 0.5517858444793835 1.6298145055770874e-09 +UQ_B20 UQ_P20 4.0 Macrophage resolver 0.4105986084412713 1.4016404747962952e-08 +UQ_B20 UQ_P20 4.0 Protease activation 0.13344428480734816 2.630287781357765e-06 +UQ_B20 UQ_P20 4.0 Antiproteolytic brake 0.3319428377781645 8.149072527885437e-10 +UQ_B20 UQ_P20 4.0 HSC retention 0.5754315460098418 8.149072527885437e-10 +UQ_B20 UQ_P20 4.0 TGF-beta integrator 0.44640101165733387 2.630287781357765e-06 +UQ_B20 UQ_P20 4.0 Structural ECM 0.4320909315429998 2.0372681319713593e-09 +UQ_B23 UQ_P23 2.0 Endothelial resolver 0.510390741178784 1.6298145055770874e-09 +UQ_B23 UQ_P23 2.0 Macrophage resolver 0.49173305976080206 1.4016404747962952e-08 +UQ_B23 UQ_P23 2.0 Protease activation 0.2599735949077833 2.630287781357765e-06 +UQ_B23 UQ_P23 2.0 Antiproteolytic brake 0.36595381008166433 8.149072527885437e-10 +UQ_B23 UQ_P23 2.0 HSC retention 0.40329030455370796 8.149072527885437e-10 +UQ_B23 UQ_P23 2.0 TGF-beta integrator 0.2424486028649554 2.630287781357765e-06 +UQ_B23 UQ_P23 2.0 Structural ECM 0.16081773288899087 2.0372681319713593e-09 +UQ_B22 UQ_SYNC 3.0 Endothelial resolver -0.02501241278442798 1.6298145055770874e-09 +UQ_B22 UQ_SYNC 3.0 Macrophage resolver 0.16333522858355978 1.4016404747962952e-08 +UQ_B22 UQ_SYNC 3.0 Protease activation 0.15541198972966735 2.630287781357765e-06 +UQ_B22 UQ_SYNC 3.0 Antiproteolytic brake 0.7191481212230142 8.149072527885437e-10 +UQ_B22 UQ_SYNC 3.0 HSC retention 0.5735412459734157 8.149072527885437e-10 +UQ_B22 UQ_SYNC 3.0 TGF-beta integrator 0.3174736402590807 2.630287781357765e-06 +UQ_B22 UQ_SYNC 3.0 Structural ECM 0.23161973685143172 2.0372681319713593e-09 +UQ_B24 UQ_P24 1.0 Endothelial resolver 0.2867003701340931 1.6298145055770874e-09 +UQ_B24 UQ_P24 1.0 Macrophage resolver 0.23124675907678113 1.4016404747962952e-08 +UQ_B24 UQ_P24 1.0 Protease activation 0.1457138766406391 2.630287781357765e-06 +UQ_B24 UQ_P24 1.0 Antiproteolytic brake 0.2331439734447946 8.149072527885437e-10 +UQ_B24 UQ_P24 1.0 HSC retention 0.24240577606268576 8.149072527885437e-10 +UQ_B24 UQ_P24 1.0 TGF-beta integrator 0.24911405494464742 2.630287781357765e-06 +UQ_B24 UQ_P24 1.0 Structural ECM 0.1131162653464593 2.0372681319713593e-09 +UQ_B21 UQ_SYNC 3.0 Endothelial resolver 0.343745394248504 1.6298145055770874e-09 +UQ_B21 UQ_SYNC 3.0 Macrophage resolver 0.2258534314474035 1.4016404747962952e-08 +UQ_B21 UQ_SYNC 3.0 Protease activation 0.1294291845076384 2.630287781357765e-06 +UQ_B21 UQ_SYNC 3.0 Antiproteolytic brake 0.7173186296265877 8.149072527885437e-10 +UQ_B21 UQ_SYNC 3.0 HSC retention 0.5545062889497057 8.149072527885437e-10 +UQ_B21 UQ_SYNC 3.0 TGF-beta integrator 0.09356736323384224 2.630287781357765e-06 +UQ_B21 UQ_SYNC 3.0 Structural ECM 0.004067213541460113 2.0372681319713593e-09 +UQ_B27 UQ_P27 4.0 Endothelial resolver 0.415766707078381 1.6298145055770874e-09 +UQ_B27 UQ_P27 4.0 Macrophage resolver 0.08288754445549582 1.4016404747962952e-08 +UQ_B27 UQ_P27 4.0 Protease activation 0.2188325236178008 2.630287781357765e-06 +UQ_B27 UQ_P27 4.0 Antiproteolytic brake 0.33720983694564677 8.149072527885437e-10 +UQ_B27 UQ_P27 4.0 HSC retention 0.5223360915252115 8.149072527885437e-10 +UQ_B27 UQ_P27 4.0 TGF-beta integrator 0.188331026089343 2.630287781357765e-06 +UQ_B27 UQ_P27 4.0 Structural ECM 0.4555333088353921 2.0372681319713593e-09 +UQ_B26 UQ_P26 4.0 Endothelial resolver 0.609484274037001 1.6298145055770874e-09 +UQ_B26 UQ_P26 4.0 Macrophage resolver 0.4146643407645537 1.4016404747962952e-08 +UQ_B26 UQ_P26 4.0 Protease activation 0.3106324696893319 2.630287781357765e-06 +UQ_B26 UQ_P26 4.0 Antiproteolytic brake 0.5813936076301237 8.149072527885437e-10 +UQ_B26 UQ_P26 4.0 HSC retention 0.8037724265693729 8.149072527885437e-10 +UQ_B26 UQ_P26 4.0 TGF-beta integrator 0.2476938541040052 2.630287781357765e-06 +UQ_B26 UQ_P26 4.0 Structural ECM 0.3617560280950167 2.0372681319713593e-09 +UQ_B25 UQ_P25 2.0 Endothelial resolver 0.21812601650937785 1.6298145055770874e-09 +UQ_B25 UQ_P25 2.0 Macrophage resolver 0.06536422473427492 1.4016404747962952e-08 +UQ_B25 UQ_P25 2.0 Protease activation 0.04827552384205566 2.630287781357765e-06 +UQ_B25 UQ_P25 2.0 Antiproteolytic brake 0.03245105239843199 8.149072527885437e-10 +UQ_B25 UQ_P25 2.0 HSC retention 0.07858802057644387 8.149072527885437e-10 +UQ_B25 UQ_P25 2.0 TGF-beta integrator -0.0424464009312249 2.630287781357765e-06 +UQ_B25 UQ_P25 2.0 Structural ECM 0.15283400514493511 2.0372681319713593e-09 +UQ_B28 UQ_P28 4.0 Endothelial resolver 0.412323756823623 1.6298145055770874e-09 +UQ_B28 UQ_P28 4.0 Macrophage resolver 0.24264737006077125 1.4016404747962952e-08 +UQ_B28 UQ_P28 4.0 Protease activation -0.1418013477498103 2.630287781357765e-06 +UQ_B28 UQ_P28 4.0 Antiproteolytic brake 0.36958996885689455 8.149072527885437e-10 +UQ_B28 UQ_P28 4.0 HSC retention 0.6307731655366128 8.149072527885437e-10 +UQ_B28 UQ_P28 4.0 TGF-beta integrator 0.12610427603682037 2.630287781357765e-06 +UQ_B28 UQ_P28 4.0 Structural ECM 0.39373117098896576 2.0372681319713593e-09 +UQ_B30 UQ_P30 0.0 Endothelial resolver 0.1790618089385829 1.6298145055770874e-09 +UQ_B30 UQ_P30 0.0 Macrophage resolver -0.0012612098558412166 1.4016404747962952e-08 +UQ_B30 UQ_P30 0.0 Protease activation -0.013548298897581468 2.630287781357765e-06 +UQ_B30 UQ_P30 0.0 Antiproteolytic brake 0.34651617194685636 8.149072527885437e-10 +UQ_B30 UQ_P30 0.0 HSC retention 0.15040349654229052 8.149072527885437e-10 +UQ_B30 UQ_P30 0.0 TGF-beta integrator 0.1019943363664672 2.630287781357765e-06 +UQ_B30 UQ_P30 0.0 Structural ECM 0.027974634870702564 2.0372681319713593e-09 +UQ_B29 UQ_P29 4.0 Endothelial resolver 0.3869506985350974 1.6298145055770874e-09 +UQ_B29 UQ_P29 4.0 Macrophage resolver 0.43244525596311845 1.4016404747962952e-08 +UQ_B29 UQ_P29 4.0 Protease activation 0.09816862411275681 2.630287781357765e-06 +UQ_B29 UQ_P29 4.0 Antiproteolytic brake 0.33207084622339733 8.149072527885437e-10 +UQ_B29 UQ_P29 4.0 HSC retention 0.257710002066389 8.149072527885437e-10 +UQ_B29 UQ_P29 4.0 TGF-beta integrator 0.21205202312154664 2.630287781357765e-06 +UQ_B29 UQ_P29 4.0 Structural ECM 0.18423012229729158 2.0372681319713593e-09 +UQ_B33 UQ_P33 3.0 Endothelial resolver 0.5248106356153446 1.6298145055770874e-09 +UQ_B33 UQ_P33 3.0 Macrophage resolver 0.5317493438642569 1.4016404747962952e-08 +UQ_B33 UQ_P33 3.0 Protease activation 0.24163090973377055 2.630287781357765e-06 +UQ_B33 UQ_P33 3.0 Antiproteolytic brake 0.7166072483946733 8.149072527885437e-10 +UQ_B33 UQ_P33 3.0 HSC retention 0.7052274929387286 8.149072527885437e-10 +UQ_B33 UQ_P33 3.0 TGF-beta integrator 0.4554665972474233 2.630287781357765e-06 +UQ_B33 UQ_P33 3.0 Structural ECM 0.30749989777589554 2.0372681319713593e-09 +UQ_B32 UQ_P32 3.0 Endothelial resolver 0.22917039098425593 1.6298145055770874e-09 +UQ_B32 UQ_P32 3.0 Macrophage resolver 0.4479828176994093 1.4016404747962952e-08 +UQ_B32 UQ_P32 3.0 Protease activation 0.08390769507943385 2.630287781357765e-06 +UQ_B32 UQ_P32 3.0 Antiproteolytic brake 0.5208630390288069 8.149072527885437e-10 +UQ_B32 UQ_P32 3.0 HSC retention 0.6883694100619859 8.149072527885437e-10 +UQ_B32 UQ_P32 3.0 TGF-beta integrator 0.1633361347905023 2.630287781357765e-06 +UQ_B32 UQ_P32 3.0 Structural ECM 0.37589727640291326 2.0372681319713593e-09 +UQ_B31 UQ_P31 0.0 Endothelial resolver 0.17107080725355028 1.6298145055770874e-09 +UQ_B31 UQ_P31 0.0 Macrophage resolver 0.14407294858058411 1.4016404747962952e-08 +UQ_B31 UQ_P31 0.0 Protease activation 0.2263511756991176 2.630287781357765e-06 +UQ_B31 UQ_P31 0.0 Antiproteolytic brake 0.042188102304344666 8.149072527885437e-10 +UQ_B31 UQ_P31 0.0 HSC retention 0.06524526220521526 8.149072527885437e-10 +UQ_B31 UQ_P31 0.0 TGF-beta integrator -0.09974120593084404 2.630287781357765e-06 +UQ_B31 UQ_P31 0.0 Structural ECM 0.10768208847920702 2.0372681319713593e-09 diff --git a/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_profile_summary.tsv b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_profile_summary.tsv new file mode 100644 index 0000000..13c8e5e --- /dev/null +++ b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_profile_summary.tsv @@ -0,0 +1,57 @@ +distance module mean ci_low ci_high n_biopsies +-3 Endothelial resolver 0.04275579732418452 0.04275579732418452 0.04275579732418452 1 +-3 Macrophage resolver -0.6854091767130309 -0.6854091767130309 -0.6854091767130309 1 +-3 Protease activation 0.4189962496740065 0.4189962496740065 0.4189962496740065 1 +-3 Antiproteolytic brake -0.4971238349334019 -0.4971238349334019 -0.4971238349334019 1 +-3 HSC retention 0.049134351647820915 0.049134351647820915 0.049134351647820915 1 +-3 TGF-beta integrator -0.32261258670630766 -0.32261258670630766 -0.32261258670630766 1 +-3 Structural ECM -0.8590838072028116 -0.8590838072028116 -0.8590838072028116 1 +-3 resolver_advantage 0.1823149800923496 0.1823149800923496 0.1823149800923496 1 +-2 Endothelial resolver -0.43869801771689443 -0.6215583749537411 -0.2344535778353997 21 +-2 Macrophage resolver -0.22726502147669048 -0.4006700250494669 -0.0635364405686883 21 +-2 Protease activation -0.11219394170395217 -0.26351354678714256 0.038159845498098435 21 +-2 Antiproteolytic brake -0.32675914344650625 -0.5982534315232559 0.03186796948641606 21 +-2 HSC retention -0.5044060988216658 -0.6367997223885342 -0.38361900110528074 21 +-2 TGF-beta integrator -0.07952420470589422 -0.3179707660688256 0.1903730615166691 21 +-2 Structural ECM -0.32290635305433774 -0.4530849846406374 -0.17962973931881912 21 +-2 resolver_advantage 0.04417748869217642 -0.11779289208452175 0.17767238678582267 21 +-1 Endothelial resolver -0.27382840263745695 -0.30732329166837713 -0.24148709144970326 33 +-1 Macrophage resolver -0.20499781783978427 -0.24563004189107315 -0.16570258583291678 33 +-1 Protease activation -0.11692132704439101 -0.15479681790437025 -0.07344476880406996 33 +-1 Antiproteolytic brake -0.2638758979445671 -0.30687238658813987 -0.2222241962950167 33 +-1 HSC retention -0.32519384752326796 -0.356424486670126 -0.2933000119867722 33 +-1 TGF-beta integrator -0.13112472675309456 -0.17580115869816665 -0.0887520014155491 33 +-1 Structural ECM -0.16978227683254285 -0.23225368938983054 -0.10250202805310238 33 +-1 resolver_advantage 0.04148230823309912 0.02602840225017277 0.057061603779564804 33 +1 Endothelial resolver 0.059576043646908314 0.006946154117856291 0.10935022907167334 33 +1 Macrophage resolver 0.015455412928302477 -0.058791292287967166 0.08850435934298082 33 +1 Protease activation -0.025434013837895814 -0.07617390305781678 0.027309220688485226 33 +1 Antiproteolytic brake 0.06510271241061936 -0.017949251499165108 0.14080904085854265 33 +1 HSC retention -0.001716004197700193 -0.08199115288998413 0.07855723805281181 33 +1 TGF-beta integrator -0.026391589483379264 -0.075756056886647 0.024309694290346524 33 +1 Structural ECM -0.052738551238850684 -0.1309258041292134 0.03165845048271079 33 +1 resolver_advantage 0.004200774669258355 -0.03764925393338231 0.05164424068918157 33 +2 Endothelial resolver 0.15504559618568292 0.04253667244984287 0.2680966882888467 33 +2 Macrophage resolver 0.1791326015585566 0.06892640940140837 0.2923159221004321 33 +2 Protease activation 0.1772560127855553 0.07510972127715322 0.27965463157099846 33 +2 Antiproteolytic brake 0.30194180627502554 0.15084332222597613 0.4674591900520668 33 +2 HSC retention 0.3404019223689536 0.15513654387201722 0.527184978987734 33 +2 TGF-beta integrator 0.11242983935600577 0.017353532749358795 0.21032624936645866 33 +2 Structural ECM 0.2657604335986066 0.12524445260727612 0.41375596443245427 33 +2 resolver_advantage -0.08111311915672999 -0.16153257433376883 -0.0020196424185584443 33 +3 Endothelial resolver 0.25231363499244686 0.015250305465507909 0.5113335573867148 28 +3 Macrophage resolver 0.4185245850494136 0.15627220589611354 0.6603569953264301 28 +3 Protease activation 0.43795871693347393 0.14699827956670078 0.7466447635289071 28 +3 Antiproteolytic brake 0.3295495516740449 0.02893821473471405 0.6245393379899646 28 +3 HSC retention 0.7395482086654707 0.3179738740815566 1.143627055506842 28 +3 TGF-beta integrator 0.3492183384286355 0.11917729563577098 0.576586476459939 28 +3 Structural ECM 0.49219271254487673 0.22309872909486775 0.7660337521271329 28 +3 resolver_advantage -0.10317305393093885 -0.3002114003429733 0.10874714834823232 28 +4 Endothelial resolver 0.23868158297246142 -0.05363843274861162 0.5054542618812492 16 +4 Macrophage resolver 0.48775354911758884 0.06550798313495707 0.9790920704932915 16 +4 Protease activation 0.4830733869763729 -0.15912187063058622 1.1858570056177864 16 +4 Antiproteolytic brake 0.7135307917321773 0.3022487576503807 1.1253717865172188 16 +4 HSC retention 1.1788093599299332 0.44292716660004483 1.9793539052370162 16 +4 TGF-beta integrator 0.5378309361838733 0.050440536452189946 1.0346923813742412 16 +4 Structural ECM 0.8109185215742769 0.45790896893433936 1.169769406015524 16 +4 resolver_advantage -0.4068875229265202 -0.7759143458820187 0.022854054590849143 16 diff --git a/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_spot_annotations.parquet b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_spot_annotations.parquet new file mode 100644 index 0000000..672a309 Binary files /dev/null and b/data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_spot_annotations.parquet differ diff --git a/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_stage_trends.tsv b/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_stage_trends.tsv new file mode 100644 index 0000000..94e5d07 --- /dev/null +++ b/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_stage_trends.tsv @@ -0,0 +1,5 @@ +metric stage_beta_array_adjusted hc3_p_value within_array_permutation_p spearman_rho spearman_p_value permutation_fdr +locked_fraction 0.03243871913389098 3.553461718547866e-05 9.999000099990002e-05 0.625235989768342 0.00010012679857715102 0.00019998000199980003 +largest_locked_domain_fraction 0.09603914800529065 0.00013954776364168145 0.00029997000299970003 0.6661168044839644 2.323376270178767e-05 0.00039996000399960006 +locked_domain_coherence 0.0997187593043891 0.003520790685010989 0.0008999100089991 0.6427563389321802 5.494690318457967e-05 0.0008999100089991 +interface_edge_fraction -0.028733200324141162 0.0003569398378699087 9.999000099990002e-05 -0.6173346558317091 0.00012971777629381808 0.00019998000199980003 diff --git a/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_threshold_sensitivity.tsv b/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_threshold_sensitivity.tsv new file mode 100644 index 0000000..9ac883e --- /dev/null +++ b/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_threshold_sensitivity.tsv @@ -0,0 +1,9 @@ +p_locked_threshold metric stage_beta_array_adjusted hc3_p_value hc3_fdr +0.4 largest_locked_domain_fraction 0.07366470518952815 0.002130593642553087 0.002130593642553087 +0.4 interface_edge_fraction -0.03248224585627828 0.00017338014850067538 0.0004623470626684677 +0.5 largest_locked_domain_fraction 0.09603914800529065 0.00013954776364168145 0.0004623470626684677 +0.5 interface_edge_fraction -0.028733200324141162 0.0003569398378699087 0.0004795001264972294 +0.6 largest_locked_domain_fraction 0.102248117132203 0.00035962509487292205 0.0004795001264972294 +0.6 interface_edge_fraction -0.027894116150220576 0.0006117912821531163 0.0006991900367464187 +0.67 largest_locked_domain_fraction 0.09348749097041878 0.000334006733761443 0.0004795001264972294 +0.67 interface_edge_fraction -0.028563074798712104 0.0001308180240038152 0.0004623470626684677 diff --git a/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_topology.tsv b/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_topology.tsv new file mode 100644 index 0000000..61bc15c --- /dev/null +++ b/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_topology.tsv @@ -0,0 +1,34 @@ +biopsy_id array patient_cluster stage_numeric stage_group n_spots locked_fraction largest_locked_domain_fraction locked_domain_coherence interface_edge_fraction n_graph_edges +UQ_B02 VLP115_A UQ_P02 1.0 early 709 0.6516220028208745 0.5909732016925247 0.9069264069264069 0.45194805194805193 1925 +UQ_B01 VLP115_A UQ_P01 3.0 late 351 0.7065527065527065 0.6923076923076923 0.9798387096774194 0.37852494577006507 922 +UQ_B04 VLP115_A UQ_P04 1.0 early 423 0.6193853427895981 0.524822695035461 0.8473282442748091 0.4395017793594306 1124 +UQ_B03 VLP115_A UQ_P03 1.0 early 260 0.6730769230769231 0.45384615384615384 0.6742857142857143 0.4270516717325228 658 +UQ_B07 VLP116_D UQ_P07 4.0 late 838 0.779236276849642 0.7565632458233891 0.9709035222052067 0.3270547945205479 2336 +UQ_B06 VLP116_D UQ_P06 3.0 intermediate 197 0.7055837563451777 0.6192893401015228 0.8776978417266187 0.4222222222222222 495 +UQ_B05 VLP116_D UQ_P05 3.0 late 514 0.6945525291828794 0.49416342412451364 0.711484593837535 0.39222873900293254 1364 +UQ_B08 VLP116_D UQ_P08 0.0 early 624 0.6698717948717948 0.6426282051282052 0.9593301435406698 0.41607981220657275 1704 +UQ_B10 VLP119_A UQ_P10 3.0 late 444 0.7927927927927928 0.7792792792792793 0.9829545454545454 0.3197573656845754 1154 +UQ_B09 VLP119_A UQ_P09 1.0 early 232 0.6853448275862069 0.47413793103448276 0.6918238993710691 0.4209558823529412 544 +UQ_B12 VLP119_A UQ_P12 1.0 early 631 0.6608557844690967 0.410459587955626 0.6211031175059952 0.42166569598136283 1717 +UQ_B11 VLP119_A UQ_P11 2.0 intermediate 384 0.640625 0.22135416666666666 0.34552845528455284 0.4349726775956284 915 +UQ_B14 VLP119_D UQ_P14 1.0 early 394 0.616751269035533 0.1751269035532995 0.2839506172839506 0.46310679611650485 1030 +UQ_B13 VLP119_D UQ_P13 4.0 late 190 0.7842105263157895 0.7526315789473684 0.959731543624161 0.2914046121593291 477 +UQ_B16 VLP119_D UQ_P16 1.0 early 508 0.7677165354330708 0.3937007874015748 0.5128205128205128 0.36106623586429726 1238 +UQ_B15 VLP119_D UQ_P15 1.0 early 163 0.5950920245398773 0.2883435582822086 0.4845360824742268 0.47680412371134023 388 +UQ_B19 VLP120_A UQ_P19 3.0 intermediate 575 0.6539130434782608 0.6278260869565218 0.9601063829787234 0.4381510416666667 1536 +UQ_B18 VLP120_A UQ_P18 0.0 early 421 0.5914489311163895 0.28978622327790976 0.4899598393574297 0.48080438756855576 1094 +UQ_B17 VLP120_A UQ_P17 0.0 early 306 0.7091503267973857 0.4084967320261438 0.576036866359447 0.4066666666666667 750 +UQ_B20 VLP120_A UQ_P20 4.0 late 582 0.7869415807560137 0.7835051546391752 0.9956331877729258 0.3146853146853147 1573 +UQ_B23 VLP120_D UQ_P23 2.0 intermediate 620 0.714516129032258 0.41451612903225804 0.5801354401805869 0.36808009422850413 1698 +UQ_B22 VLP120_D UQ_SYNC 3.0 late 339 0.7433628318584071 0.7345132743362832 0.9880952380952381 0.3010033444816054 897 +UQ_B24 VLP120_D UQ_P24 1.0 early 608 0.680921052631579 0.3404605263157895 0.5 0.4434416365824308 1662 +UQ_B21 VLP120_D UQ_SYNC 3.0 late 83 0.7469879518072289 0.6987951807228916 0.9354838709677419 0.37373737373737376 198 +UQ_B27 VLP121_A UQ_P27 4.0 late 590 0.676271186440678 0.6610169491525424 0.9774436090225563 0.41838649155722324 1599 +UQ_B26 VLP121_A UQ_P26 4.0 late 465 0.7913978494623656 0.7870967741935484 0.9945652173913043 0.3156225218080888 1261 +UQ_B25 VLP121_A UQ_P25 2.0 intermediate 334 0.5658682634730539 0.5 0.8835978835978836 0.4771689497716895 876 +UQ_B28 VLP121_A UQ_P28 4.0 late 117 0.6837606837606838 0.26495726495726496 0.3875 0.3886792452830189 265 +UQ_B30 VLP121_D UQ_P30 0.0 early 405 0.6370370370370371 0.24444444444444444 0.38372093023255816 0.4234647112740605 1091 +UQ_B29 VLP121_D UQ_P29 4.0 late 361 0.7091412742382271 0.7091412742382271 1.0 0.4224049331963001 973 +UQ_B33 VLP121_D UQ_P33 3.0 late 444 0.7477477477477478 0.7364864864864865 0.9849397590361446 0.35175879396984927 1194 +UQ_B32 VLP121_D UQ_P32 3.0 late 284 0.7464788732394366 0.7288732394366197 0.9764150943396226 0.3724966622162884 749 +UQ_B31 VLP121_D UQ_P31 0.0 early 189 0.6084656084656085 0.4708994708994709 0.7739130434782608 0.502127659574468 470 diff --git a/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_wall_summary.json b/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_wall_summary.json new file mode 100644 index 0000000..f592adf --- /dev/null +++ b/data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_wall_summary.json @@ -0,0 +1,27 @@ +{ + "n_spots": 13585, + "n_biopsies": 33, + "n_patients": 32, + "boundary_definition": "p_locked >= 0.5; signed shortest-path distance to nearest opposite-basin spot", + "largest_domain_stage_beta": 0.09603914800529065, + "largest_domain_permutation_fdr": 0.00039996000399960006, + "interface_stage_beta": -0.028733200324141162, + "interface_permutation_fdr": 0.00019998000199980003, + "threshold_sensitivity": { + "thresholds": [ + 0.4, + 0.5, + 0.6, + 0.67 + ], + "largest_domain_beta_range": [ + 0.07366470518952815, + 0.102248117132203 + ], + "interface_beta_range": [ + -0.03248224585627828, + -0.027894116150220576 + ] + }, + "interpretation": "Fibrosis progression consolidates initially fragmented locked islands into a dominant spatial domain while compressing the resolved-locked interface; across that interface the resolver advantage changes sign as HSC retention and antiproteolytic control overtake resolver activity." +} diff --git a/data/UQ_spatial_mapping_derived/UQ_Visium_component_summary.tsv b/data/UQ_spatial_mapping_derived/UQ_Visium_component_summary.tsv new file mode 100644 index 0000000..fb0a972 --- /dev/null +++ b/data/UQ_spatial_mapping_derived/UQ_Visium_component_summary.tsv @@ -0,0 +1,53 @@ +array component n_spots centroid_col centroid_row published_primary +VLP115_A C1 351 6.0398860398860394 30.558404558404558 True +VLP115_A C2 670 36.14179104477612 36.744776119402985 True +VLP115_A C3 24 38.958333333333336 75.95833333333333 True +VLP115_A C4 190 74.41052631578947 30.157894736842106 True +VLP115_A C5 70 81.6 51.8 True +VLP115_A C6 423 108.71158392434988 38.7919621749409 True +VLP116_D C1 514 15.120622568093385 33.7704280155642 True +VLP116_D C2 29 27.896551724137932 15.96551724137931 True +VLP116_D C3 168 40.017857142857146 59.81547619047619 True +VLP116_D C4 838 74.65513126491646 38.80310262529833 True +VLP116_D C5 624 109.59294871794872 41.00320512820513 True +VLP119_A C1 232 4.900862068965517 33.97844827586207 True +VLP119_A C2 444 31.85135135135135 42.72072072072072 True +VLP119_A C3 97 60.68041237113402 63.7319587628866 True +VLP119_A C4 203 64.11330049261083 32.389162561576356 True +VLP119_A C5 22 75.4090909090909 14.045454545454545 True +VLP119_A C6 56 76.35714285714286 60.642857142857146 True +VLP119_A C7 631 98.53724247226624 35.687797147385105 True +VLP119_D C1 184 8.152173913043478 41.29347826086956 True +VLP119_D C2 390 33.62307692307692 37.51538461538462 True +VLP119_D C3 163 62.533742331288344 46.8159509202454 True +VLP119_D C4 21 89.61904761904762 4.0 True +VLP119_D C5 289 94.73010380622837 46.95847750865052 True +VLP119_D C6 198 108.79797979797979 29.31313131313131 True +VLP120_A C1 107 9.719626168224298 11.233644859813085 True +VLP120_A C2 193 11.27461139896373 45.48186528497409 True +VLP120_A C3 421 35.91686460807601 34.86698337292162 True +VLP120_A C4 575 70.53217391304348 39.65217391304348 True +VLP120_A C5 582 102.9278350515464 36.71134020618557 True +VLP120_D C1 79 36.48101265822785 13.974683544303797 True +VLP120_D C2 339 43.70796460176991 47.73746312684366 True +VLP120_D C3 620 70.57741935483871 36.26451612903226 True +VLP120_D C4 608 104.57565789473684 40.25 True +VLP121_A C1 334 10.497005988023952 37.30538922155689 True +VLP121_A C2 465 40.21075268817204 33.19139784946236 True +VLP121_A C3 590 73.22033898305085 33.68135593220339 True +VLP121_A C4 88 94.79545454545455 40.84090909090909 True +VLP121_A C5 24 113.29166666666667 61.458333333333336 True +VLP121_D C1 361 10.285318559556787 39.686980609418285 True +VLP121_D C2 405 35.135802469135804 34.59753086419753 True +VLP121_D C3 189 56.75132275132275 35.80952380952381 True +VLP121_D C4 284 76.7394366197183 36.79577464788732 True +VLP121_D C5 444 101.37837837837837 39.527027027027025 True +VLP115_D C1 553 15.2875226039783 37.89873417721519 False +VLP115_D C2 516 46.32945736434109 39.48837209302326 False +VLP115_D C3 334 75.54191616766467 42.116766467065865 False +VLP115_D C4 469 103.65245202558636 43.507462686567166 False +VLP116_A C1 365 9.326027397260274 46.66301369863014 False +VLP116_A C2 35 26.02857142857143 73.45714285714286 False +VLP116_A C3 333 31.324324324324323 37.486486486486484 False +VLP116_A C4 641 60.66302652106084 44.00468018720749 False +VLP116_A C5 684 98.09502923976608 42.5921052631579 False diff --git a/data/UQ_spatial_mapping_derived/UQ_Visium_spot_component_map.parquet b/data/UQ_spatial_mapping_derived/UQ_Visium_spot_component_map.parquet new file mode 100644 index 0000000..426dd7b Binary files /dev/null and b/data/UQ_spatial_mapping_derived/UQ_Visium_spot_component_map.parquet differ diff --git a/data/clinical_aggregate/Table1_baseline_8142.tsv b/data/clinical_aggregate/Table1_baseline_8142.tsv new file mode 100644 index 0000000..343901b --- /dev/null +++ b/data/clinical_aggregate/Table1_baseline_8142.tsv @@ -0,0 +1,11 @@ +Variable All (n=8,142) LSM <9.5 (n=5,857) LSM >=9.5 (n=2,285) SMD +Age, years 44.0 [35.0, 56.0] 42.0 [35.0, 54.0] 48.0 [37.0, 61.0] 0.28664956397919855 +Male sex 5,016 (61.6%) 3,509 (59.9%) 1,507 (66.0%) 0.1253133984250813 +BMI, kg/m2 25.4 [23.0, 28.0] 24.8 [22.6, 27.2] 27.3 [24.5, 30.7] 0.6828632655864458 +CAP, dB/m 273.0 [237.7, 295.6] 266.4 [231.6, 287.7] 290.6 [263.3, 312.3] 0.6305815147602205 +LSM, kPa 7.6 [6.1, 9.9] 6.7 [5.7, 7.8] 11.9 [10.5, 14.8] 2.2819493176477317 +CAP >=248 dB/m 5,665 (69.6%) 3,804 (64.9%) 1,861 (81.4%) 0.37905841318681954 +CAP >=280 dB/m 3,413 (41.9%) 2,013 (34.4%) 1,400 (61.3%) 0.5591635398435819 +LSM 9.5-<12.5 kPa 1,322 (16.2%) 0 (0.0%) 1,322 (57.9%) 1.6569812033344042 +LSM >=12.5 kPa 963 (11.8%) 0 (0.0%) 963 (42.1%) 1.2070142956210523 +Gastro/hepatobiliary 5,856 (71.9%) 4,204 (71.8%) 1,652 (72.3%) 0.01159144050622258 diff --git a/data/clinical_aggregate/clinical_analysis_summary.json b/data/clinical_aggregate/clinical_analysis_summary.json new file mode 100644 index 0000000..a7496c9 --- /dev/null +++ b/data/clinical_aggregate/clinical_analysis_summary.json @@ -0,0 +1,24 @@ +{ + "cohort": { + "raw_scans": 9703, + "technical_qc_scans": 9644, + "adult_qc_scans": 9562, + "adult_index_patients": 8142, + "advanced_lsm_n": 2285, + "advanced_lsm_fraction": 0.2806435765168263, + "retention_phenotype_n": 885 + }, + "longitudinal": { + "n": 772, + "median_followup_days": 291.5, + "outcomes": { + "Persistent nonadvanced": 442, + "Persistent advanced": 154, + "Threshold regression": 143, + "Threshold progression": 33 + }, + "regression_resistant_n": 115 + }, + "ethics": "See the associated manuscript for the institutionally approved ethics and consent-waiver statement; source documents are not redistributed.", + "clinical_event_boundary": "readmission, decompensation, mortality, transplant, treatment exposure, and prescription outcomes not present in current source files" +} diff --git a/data/clinical_aggregate/clinical_validation_metrics.tsv b/data/clinical_aggregate/clinical_validation_metrics.tsv new file mode 100644 index 0000000..a80e0e1 --- /dev/null +++ b/data/clinical_aggregate/clinical_validation_metrics.tsv @@ -0,0 +1,4 @@ +validation n advanced_n advanced_fraction AUROC ci_low ci_high Brier +Internal 5-fold CV (2023-2024) 4525 1078 0.23823204419889502 0.725652378207395 0.7096105085382661 0.7430528451107486 0.1583535348344928 +Temporal holdout (2025-2026) 3617 1207 0.33370196295272325 0.741058211607944 0.7246518618632461 0.7586576774670423 0.18988343516996176 +Independent department subcohort 2286 633 0.2769028871391076 0.7431650434033005 0.7199912674036221 0.7641716552749981 0.16736339795971744 diff --git a/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_2_state_composition.tsv b/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_2_state_composition.tsv new file mode 100644 index 0000000..5e68e0a --- /dev/null +++ b/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_2_state_composition.tsv @@ -0,0 +1,25 @@ +disease cell_state_v1 n fraction +cirrhotic B_cell 1460 0.056820393072582215 +cirrhotic Cholangiocyte 2354 0.09161315431017708 +cirrhotic Cycling 378 0.014711033274956218 +cirrhotic Endothelial 4738 0.18439385094376337 +cirrhotic HSC_Myofibroblast 760 0.02957773885970033 +cirrhotic Hepatocyte 113 0.004397742751508076 +cirrhotic Lymphatic_endothelial 242 0.009418174742167737 +cirrhotic Macrophage_Kupffer 2192 0.08530842576376726 +cirrhotic Mast_cell 124 0.004825841603424791 +cirrhotic Monocyte_inflammatory 2198 0.08554193422844912 +cirrhotic Plasma_cell 498 0.01938120256859311 +cirrhotic T_NK 10638 0.4140105078809107 +healthy B_cell 1103 0.03149089247987209 +healthy Cholangiocyte 1118 0.031919145777422483 +healthy Cycling 507 0.014474961457203221 +healthy Endothelial 3074 0.0877633757779935 +healthy HSC_Myofibroblast 1605 0.04582310283789185 +healthy Hepatocyte 39 0.001113458573631017 +healthy Lymphatic_endothelial 52 0.0014846114315080227 +healthy Macrophage_Kupffer 3372 0.09627134128932793 +healthy Mast_cell 106 0.003026323302689431 +healthy Monocyte_inflammatory 2771 0.07911265916747559 +healthy Plasma_cell 410 0.011705590133044024 +healthy T_NK 20869 0.5958145377719408 diff --git a/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_6_metabolic_models.tsv b/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_6_metabolic_models.tsv new file mode 100644 index 0000000..c3cd95d --- /dev/null +++ b/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_6_metabolic_models.tsv @@ -0,0 +1,21 @@ +domain analyte endpoint transform n_available n_keys median_raw iqr_raw spearman_rho spearman_p analysis_status adjusted_n adjusted_n_keys beta_per_SD ci_low ci_high p_value model_status q_value_BH +metabolic FERR CAP_dB_per_m log1p 18 18 483.515 290.1375 0.2818792321950489 0.2571192297222308 model_candidate 18 18 insufficient_n +metabolic FERR log_LSM log1p 18 18 483.515 290.1375 0.3397006131581359 0.1678372103509573 model_candidate 18 18 insufficient_n +metabolic FPG CAP_dB_per_m identity 325 325 5.64 1.04 0.1180771768046959 0.033344203002993 model_candidate 325 325 2.408999731875122 0.6855674933930571 4.132431970357187 0.0061509899240171 fit_HC3 0.0221435637264617 +metabolic FPG log_LSM identity 325 325 5.64 1.04 0.1716034018024441 0.0019042886746766 model_candidate 325 325 0.0539455209972997 0.0209037157781694 0.08698732621643 0.001374636459796 fit_HC3 0.0061858640690823 +metabolic HDL CAP_dB_per_m identity 924 924 1.16 0.33 -0.2358631063772489 3.796667118597679e-13 model_candidate 924 924 -3.078939665757072 -4.464023115966667 -1.6938562155474783 1.3194326505494578e-05 fit_HC3 0.0001187489385494 +metabolic HDL log_LSM identity 924 924 1.16 0.33 -0.1281444157092553 9.37998054525605e-05 model_candidate 924 924 -0.0010109246990508 -0.0248213919238832 0.0227995425257816 0.9336809875249972 fit_HC3 0.9336809875249972 +metabolic HbA1c CAP_dB_per_m identity 229 229 5.9 0.8999999999999995 -0.0109762642924933 0.8687888911633967 model_candidate 229 229 1.5415674070464656 -1.4933030426635074 4.576437856756439 0.3194606188540635 fit_HC3 0.522753739943013 +metabolic HbA1c log_LSM identity 229 229 5.9 0.8999999999999995 0.1036989725725784 0.1176099616108575 model_candidate 229 229 0.0314556450089006 -0.0106917750765433 0.0736030650943445 0.1435306515983882 fit_HC3 0.2870613031967764 +metabolic INS CAP_dB_per_m log1p 123 123 120.54 97.45000000000002 0.4270485354245399 8.399082430637776e-07 model_candidate 123 123 0.2961056742954007 -3.092393561921119 3.68460491051192 0.8640095673157642 fit_HC3 0.9336809875249972 +metabolic INS log_LSM log1p 123 123 120.54 97.45000000000002 0.3411216158697811 0.0001128938641251 model_candidate 123 123 0.0497072926788269 -0.0156417036744905 0.1150562890321445 0.1360050916931476 fit_HC3 0.2870613031967764 +metabolic LDL CAP_dB_per_m identity 924 924 2.915 1.1525 0.0462673348777608 0.1599457580845292 model_candidate 924 924 0.6699954972862141 -0.5400570564981961 1.8800480510706243 0.2778264925465468 fit_HC3 0.5000876865837842 +metabolic LDL log_LSM identity 924 924 2.915 1.1525 -0.0077299084605821 0.8144770506714263 model_candidate 924 924 -0.0023921241364233 -0.0216458650789023 0.0168616168060555 0.807610391760442 fit_HC3 0.9336809875249972 +metabolic TC CAP_dB_per_m identity 926 926 5.005 1.3475 -0.0177080018459139 0.5904574575553295 model_candidate 926 926 0.3800149489347741 -0.7890815593883702 1.5491114572579183 0.5240684955113957 fit_HC3 0.725633301477317 +metabolic TC log_LSM identity 926 926 5.005 1.3475 0.0082099695808637 0.8029754632652933 model_candidate 926 926 0.0079597842351539 -0.0121814531114603 0.0281010215817681 0.4385910838287399 fit_HC3 0.6578866257431099 +metabolic TG CAP_dB_per_m log1p 926 926 1.7 1.27 0.2361774448131338 3.3266253341376424e-13 model_candidate 926 926 3.775449540102695 2.5833384234532364 4.967560656752154 5.39159333859818e-10 fit_HC3 9.704868009476725e-09 +metabolic TG log_LSM log1p 926 926 1.7 1.27 0.1471884737670016 6.877381289446055e-06 model_candidate 926 926 0.0052534475775693 -0.0158218802449558 0.0263287754000946 0.6251530399315623 fit_HC3 0.8037681941977229 +metabolic UA CAP_dB_per_m log1p 662 662 393.0 136.0 0.2755636348018163 5.320071861010089e-13 model_candidate 662 662 2.4849499154789383 1.1046278499750026 3.865271980982874 0.0004179838054818 fit_HC3 0.0025079028328913 +metabolic UA log_LSM log1p 662 662 393.0 136.0 0.1226263193248353 0.0015718986355294 model_candidate 662 662 0.0360568938655315 0.0078055103905868 0.0643082773404762 0.0123676136868854 fit_HC3 0.0371028410606564 +metabolic hsCRP CAP_dB_per_m log1p 202 202 1.13 2.7575 0.1856935534031413 0.0081479913822019 model_candidate 202 202 -0.1250016371777316 -2.9063290143513263 2.656325739995863 0.9298075509416204 fit_HC3 0.9336809875249972 +metabolic hsCRP log_LSM log1p 202 202 1.13 2.7575 0.1955960120757104 0.0052759037467434 model_candidate 202 202 0.0407139150781492 -0.0055182147516405 0.086946044907939 0.0843429333843945 fit_HC3 0.2168818287027288 diff --git a/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_7_LIS_models.tsv b/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_7_LIS_models.tsv new file mode 100644 index 0000000..318dd17 --- /dev/null +++ b/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_7_LIS_models.tsv @@ -0,0 +1,77 @@ +domain analyte endpoint transform n_available n_keys median_raw iqr_raw spearman_rho spearman_p analysis_status adjusted_n adjusted_n_keys beta_per_SD ci_low ci_high p_value model_status q_value_BH section marker_or_phenotype n_observed n_positive proportion interpretation +LIS AFP CAP_dB_per_m log1p 143.0 143.0 3.17 2.115 0.0380689304842099 0.6516966423907472 model_candidate 143.0 143.0 -0.2348829659749105 -3.681654414934511 3.21188848298469 0.8937479099383628 fit_HC3 0.9231485924862696 models +LIS AFP log_LSM log1p 143.0 143.0 3.17 2.115 0.0269132751939098 0.7496740840259845 model_candidate 143.0 143.0 0.052726550765538 -0.021004386942128 0.1264574884732042 0.1610312491391968 fit_HC3 0.3526561675005722 models +LIS ALB CAP_dB_per_m identity 353.0 353.0 46.1 3.299999999999997 0.1753337430412122 0.0009389745435919 model_candidate 353.0 353.0 3.798140215754064 0.6864246736081845 6.909855757899942 0.0167422570741099 fit_HC3 0.0540144488132959 models +LIS ALB log_LSM identity 353.0 353.0 46.1 3.299999999999997 -0.0620922316723399 0.2445892342193637 model_candidate 353.0 353.0 -0.0238051047778414 -0.0603070765547977 0.0126968669991149 0.2011757516369345 fit_HC3 0.3623050426662385 models +LIS ALP CAP_dB_per_m log1p 359.0 359.0 78.0 27.5 0.1280120395478859 0.0152235723489616 model_candidate 359.0 359.0 2.045887495492085 -0.0563135881639889 4.148088579148159 0.0564609643166541 fit_HC3 0.1442891310314494 models +LIS ALP log_LSM log1p 359.0 359.0 78.0 27.5 0.1189430889845782 0.0242089638843159 model_candidate 359.0 359.0 0.0361073510263411 0.0062928401259948 0.0659218619266875 0.0176134072217269 fit_HC3 0.0540144488132959 models +LIS ALT CAP_dB_per_m log1p 252.0 252.0 29.0 33.0 0.4616725977839143 1.0450313919516446e-14 model_candidate 252.0 252.0 7.31561294720178 4.866433308191077 9.764792586212485 4.788990939135611e-09 fit_HC3 7.343119440007937e-08 models +LIS ALT log_LSM log1p 252.0 252.0 29.0 33.0 0.3584986709175937 4.668228577716777e-09 model_candidate 252.0 252.0 0.1041223774557723 0.0589067820304916 0.1493379728810529 6.379626136770071e-06 fit_HC3 4.1923257470203325e-05 models +LIS AMA_M2 CAP_dB_per_m identity 27.0 27.0 2.0 0.0 -0.3275890282588977 0.0953064384242313 marker_registry_only models +LIS AMA_M2 log_LSM identity 27.0 27.0 2.0 0.0 -0.4580374121110324 0.0162793399565851 marker_registry_only models +LIS AST CAP_dB_per_m log1p 360.0 360.0 27.0 14.25 0.3931172126156131 9.405012716567873e-15 model_candidate 360.0 360.0 5.455837088709439 3.540741990451843 7.370932186967035 2.355058646370761e-08 fit_HC3 2.708317443326376e-07 models +LIS AST log_LSM log1p 360.0 360.0 27.0 14.25 0.4390604444438859 2.134916408553981e-18 model_candidate 360.0 360.0 0.1137283159045289 0.0824466060037524 0.1450100258053055 1.0356932003588813e-12 fit_HC3 4.764188721650853e-11 models +LIS BUN CAP_dB_per_m log1p 60.0 60.0 5.3 1.4750000000000003 0.0639397574907433 0.6274254267275822 model_candidate 60.0 60.0 4.712409995728271 -1.9973903565269888 11.42221034798353 0.1686616453263606 fit_HC3 0.3526561675005722 models +LIS BUN log_LSM log1p 60.0 60.0 5.3 1.4750000000000003 0.043368803731205 0.7421394585600869 model_candidate 60.0 60.0 0.0125984461770498 -0.0835135262415665 0.1087104185956661 0.7972452472578462 fit_HC3 0.8528670086944401 models +LIS C3 CAP_dB_per_m identity 11.0 11.0 1.05 0.15 0.2636363636363636 0.4334407376116145 model_candidate 11.0 11.0 insufficient_n models +LIS C3 log_LSM identity 11.0 11.0 1.05 0.15 -0.1181818181818181 0.7292847795197801 model_candidate 11.0 11.0 insufficient_n models +LIS C4 CAP_dB_per_m identity 11.0 11.0 0.26 0.08 -0.5636363636363637 0.0709517344763755 model_candidate 11.0 11.0 insufficient_n models +LIS C4 log_LSM identity 11.0 11.0 0.26 0.08 -0.4000000000000001 0.22286835013352 model_candidate 11.0 11.0 insufficient_n models +LIS CIV CAP_dB_per_m log1p 82.0 82.0 42.965 14.112499999999995 0.1723207191911276 0.1216030067549916 model_candidate 82.0 82.0 -2.175851684073121 -9.097133483851064 4.745430115704821 0.5377914099301815 fit_HC3 0.7276001428467161 models +LIS CIV log_LSM log1p 82.0 82.0 42.965 14.112499999999995 0.2598905105516919 0.0183761126824592 model_candidate 82.0 82.0 0.0506682254984322 -0.0158999721825305 0.1172364231793949 0.135745833307236 fit_HC3 0.312215416606643 models +LIS GGT CAP_dB_per_m log1p 359.0 359.0 32.0 34.5 0.4251519613702924 3.434604028119936e-17 model_candidate 359.0 359.0 5.84321226960578 3.5044557290291 8.18196881018246 9.73966330123297e-07 fit_HC3 8.09946555285308e-06 models +LIS GGT log_LSM log1p 359.0 359.0 32.0 34.5 0.3788566477571091 1.068540010429262e-13 model_candidate 359.0 359.0 0.1000324012629477 0.067885822561424 0.1321789799644714 1.0677727162340961e-09 fit_HC3 2.4558772473384207e-08 models +LIS GLU CAP_dB_per_m identity 60.0 60.0 5.495 0.7649999999999988 0.0049463680625693 0.9700794579835168 model_candidate 60.0 60.0 2.49558367382701 -1.368513908372429 6.359681256026449 0.2055773365767308 fit_HC3 0.3623050426662385 models +LIS GLU log_LSM identity 60.0 60.0 5.495 0.7649999999999988 0.3147612980040618 0.0143073202696777 model_candidate 60.0 60.0 0.0514908396504008 -0.1194238445104448 0.2224055238112465 0.5548748175482293 fit_HC3 0.72926404592053 models +LIS HA CAP_dB_per_m log1p 82.0 82.0 82.35 65.275 0.0451136821360922 0.6873490635027333 model_candidate 82.0 82.0 -1.105839176458213 -6.976460888029675 4.764782535113249 0.7119822839758942 fit_HC3 0.8397739759715677 models +LIS HA log_LSM log1p 82.0 82.0 82.35 65.275 0.2659476050652389 0.0157374262003172 model_candidate 82.0 82.0 0.1414715217411933 0.0846615919635549 0.1982814515188316 1.0564520286330106e-06 fit_HC3 8.09946555285308e-06 models +LIS HBsAg CAP_dB_per_m identity 156.0 156.0 82.925 958.5825 -0.3195453365624728 4.779627746087301e-05 marker_registry_only models +LIS HBsAg log_LSM identity 156.0 156.0 82.925 958.5825 -0.2606830449952498 0.001013462724895 marker_registry_only models +LIS IBIL CAP_dB_per_m log1p 354.0 354.0 8.8 5.1 -0.0968002516900338 0.0688933638093316 model_candidate 354.0 354.0 -0.368585474804431 -2.794289146451824 2.057118196842961 0.7658433217287924 fit_HC3 0.8496984640316505 models +LIS IBIL log_LSM log1p 354.0 354.0 8.8 5.1 -0.0797095953134781 0.1344439186825327 model_candidate 354.0 354.0 -0.0045311583802979 -0.0357161584040512 0.0266538416434553 0.7758116410723765 fit_HC3 0.8496984640316505 models +LIS INR CAP_dB_per_m log1p 10.0 10.0 1.045 0.1300000000000001 -0.0303952771840032 0.9335717251179998 model_candidate 10.0 10.0 insufficient_n models +LIS INR log_LSM log1p 10.0 10.0 1.045 0.1300000000000001 0.3282689935872349 0.3544183270183251 model_candidate 10.0 10.0 insufficient_n models +LIS IgG CAP_dB_per_m identity 14.0 14.0 13.83 4.452500000000001 -0.2923076923076923 0.310526320385882 model_candidate 14.0 14.0 insufficient_n models +LIS IgG log_LSM identity 14.0 14.0 13.83 4.452500000000001 -0.5868131868131868 0.0273843755310877 model_candidate 14.0 14.0 insufficient_n models +LIS IgM CAP_dB_per_m identity 14.0 14.0 1.09 1.2175 -0.3538461538461538 0.2145398708812465 model_candidate 14.0 14.0 insufficient_n models +LIS IgM log_LSM identity 14.0 14.0 1.09 1.2175 -0.0021978021978021 0.9940505286658996 model_candidate 14.0 14.0 insufficient_n models +LIS LN CAP_dB_per_m log1p 82.0 82.0 60.52 31.054999999999996 -0.0779490751585597 0.4863769852150775 model_candidate 82.0 82.0 -2.314478500212348 -8.004315385755561 3.3753583853308653 0.425298500201116 fit_HC3 0.6113665940391043 models +LIS LN log_LSM log1p 82.0 82.0 60.52 31.054999999999996 0.3403660189100305 0.0017551527491052 model_candidate 82.0 82.0 0.0804425023618761 0.0173602650211443 0.1435247397026078 0.0124422375183542 fit_HC3 0.0476952438203581 models +LIS LYM CAP_dB_per_m log1p 121.0 121.0 1.9 0.8799999999999999 0.1716348147327369 0.059784521332903 model_candidate 121.0 121.0 3.0829695549290634 -0.8416455687509554 7.007584678609082 0.1236472058714838 fit_HC3 0.2993563931625398 models +LIS LYM log_LSM log1p 121.0 121.0 1.9 0.8799999999999999 -0.1076134604836156 0.2400443009537387 model_candidate 121.0 121.0 -0.0379956180822967 -0.0971161810897377 0.0211249449251442 0.2078028177733065 fit_HC3 0.3623050426662385 models +LIS MONO CAP_dB_per_m log1p 121.0 121.0 0.42 0.21 0.2138651858157582 0.0185018574489087 model_candidate 121.0 121.0 6.895786082449838 3.5397910469189804 10.251781117980697 5.642863317081359e-05 fit_HC3 0.0003244646407321 models +LIS MONO log_LSM log1p 121.0 121.0 0.42 0.21 0.0736852703177422 0.4218491570654838 model_candidate 121.0 121.0 0.0383272000838038 -0.0219475567195138 0.0986019568871214 0.2126573076519226 fit_HC3 0.3623050426662385 models +LIS NEU CAP_dB_per_m log1p 121.0 121.0 3.3 1.5200000000000005 0.2535581945692538 0.0050129420447028 model_candidate 121.0 121.0 4.025047543403375 0.6170566817657268 7.433038405041023 0.0206217758249494 fit_HC3 0.0592876054967295 models +LIS NEU log_LSM log1p 121.0 121.0 3.3 1.5200000000000005 0.1498912727163492 0.1008028084637683 model_candidate 121.0 121.0 0.0298302003436881 -0.0228440319356508 0.0825044326230271 0.2670176750616134 fit_HC3 0.4386718947440792 models +LIS PIIINP CAP_dB_per_m log1p 82.0 82.0 7.915 4.722499999999999 0.1881812591742896 0.0904449535712347 model_candidate 82.0 82.0 -0.0489792549524719 -5.109412955889984 5.0114544459850405 0.9848648565984984 fit_HC3 0.9848648565984984 models +LIS PIIINP log_LSM log1p 82.0 82.0 7.915 4.722499999999999 0.1441562046132716 0.1963188951343121 model_candidate 82.0 82.0 -0.0098381602659129 -0.0669223621249289 0.047246041593103 0.7355218786410467 fit_HC3 0.8458501604372037 models +LIS PLT CAP_dB_per_m identity 121.0 121.0 183.0 68.0 0.1909158968176021 0.0359395570069767 model_candidate 121.0 121.0 5.164923073865241 2.1594845804293867 8.170361567301095 0.000756474240002 fit_HC3 0.0038664238933438 models +LIS PLT log_LSM identity 121.0 121.0 183.0 68.0 -0.171459154485529 0.0600503421881035 model_candidate 121.0 121.0 -0.0362045415547537 -0.1802802959905631 0.1078712128810556 0.6223546960303079 fit_HC3 0.7533767372998463 models +LIS PT CAP_dB_per_m log1p 10.0 10.0 12.05 1.3999999999999986 -0.085106776115209 0.815171544541529 model_candidate 10.0 10.0 insufficient_n models +LIS PT log_LSM log1p 10.0 10.0 12.05 1.3999999999999986 0.2735574946560291 0.4443991414688369 model_candidate 10.0 10.0 insufficient_n models +LIS TBIL CAP_dB_per_m log1p 44.0 44.0 17.4 6.675000000000001 0.0422832980972515 0.7852198374535636 model_candidate 44.0 44.0 -0.2903071897722213 -4.962932356640869 4.3823179770964265 0.9030801448235244 fit_HC3 0.9231485924862696 models +LIS TBIL log_LSM log1p 44.0 44.0 17.4 6.675000000000001 0.1417899929527836 0.3585652541295324 model_candidate 44.0 44.0 0.0419112560541703 -0.0729612859142826 0.1567837980226233 0.4745515696033739 fit_HC3 0.6614961273259152 models +LIS WBC CAP_dB_per_m log1p 121.0 121.0 5.89 2.119999999999999 0.2824200465299347 0.0016980161148473 model_candidate 121.0 121.0 5.239074248994485 1.7032559290207177 8.774892568968252 0.0036830156460168 fit_HC3 0.0169418719716775 models +LIS WBC log_LSM log1p 121.0 121.0 5.89 2.119999999999999 0.068450788202488 0.4556561966603612 model_candidate 121.0 121.0 0.0141133175154254 -0.0405603442879101 0.0687869793187609 0.6128987505470365 fit_HC3 0.7533767372998463 models +LIS anti_HCV CAP_dB_per_m identity 51.0 51.0 0.01 0.0049999999999999 -0.3111889152996814 0.0262327685608221 marker_registry_only models +LIS anti_HCV log_LSM identity 51.0 51.0 0.01 0.0049999999999999 0.0208700374555516 0.884424504180054 marker_registry_only models +LIS LIS_HDL CAP_dB_per_m identity 198.0 198.0 1.165 0.3499999999999998 -0.2984688460311409 1.946030591005601e-05 model_candidate 198.0 198.0 -1.8304438806054424 -5.175305048798509 1.5144172875876238 0.2834632403768088 fit_HC3 0.4496313468045933 models +LIS LIS_HDL log_LSM identity 198.0 198.0 1.165 0.3499999999999998 0.0073065412240825 0.9186276521292992 model_candidate 198.0 198.0 0.0497692955842293 0.0097167248597 0.0898218663087585 0.0148732866449657 fit_HC3 0.0526285527437248 models +LIS LIS_LDL CAP_dB_per_m identity 198.0 198.0 2.82 0.9925000000000002 0.0899123680726448 0.207769776807252 model_candidate 198.0 198.0 1.9259817170331808 -0.8658737046979523 4.717837138764314 0.1763448070395954 fit_HC3 0.3526896140791908 models +LIS LIS_LDL log_LSM identity 198.0 198.0 2.82 0.9925000000000002 0.0145704184825799 0.8385592938974098 model_candidate 198.0 198.0 0.0112890600220996 -0.0293113453488992 0.0518894653930984 0.5857716411693479 fit_HC3 0.7484859859386112 models +LIS LIS_TC CAP_dB_per_m identity 198.0 198.0 4.865 1.2300000000000004 0.0464156678427811 0.5161179016859487 model_candidate 198.0 198.0 1.3928813578991208 -1.4485575486524238 4.234320264450665 0.3366628633638632 fit_HC3 0.4995642488625066 models +LIS LIS_TC log_LSM identity 198.0 198.0 4.865 1.2300000000000004 0.1005613539786678 0.1586459391824493 model_candidate 198.0 198.0 0.043787576003911 0.0038524351404847 0.0837227168673372 0.0316315134621166 fit_HC3 0.0855911540739627 models +LIS LIS_TG CAP_dB_per_m log1p 198.0 198.0 1.625 1.1175000000000002 0.4453068689400313 4.913592892207979e-11 model_candidate 198.0 198.0 5.329039648419962 1.3487906434476642 9.30928865339226 0.0086868380581746 fit_HC3 0.0363267773341849 models +LIS LIS_TG log_LSM log1p 198.0 198.0 1.625 1.1175000000000002 0.2028453811304669 0.0041559974119741 model_candidate 198.0 198.0 0.0193341763694171 -0.0193583279935543 0.0580266807323886 0.3273970496380685 fit_HC3 0.4995642488625066 models + 0.5650678720417956 0.721963640647153 etiology HBsAg_marker_positive 139.0 90.0 0.6474820143884892 marker_or_partial_phenotype_not_definitive_etiology + 0.0125551099495949 0.1513499843762966 etiology anti_HCV_marker_positive 44.0 2.0 0.0454545454545454 marker_or_partial_phenotype_not_definitive_etiology + 0.0400324462361061 0.2897590321171364 etiology AMA_M2_marker_positive 26.0 3.0 0.1153846153846153 marker_or_partial_phenotype_not_definitive_etiology + 0.8091412294876675 0.8786208825708123 etiology metabolic_risk_observed 412.0 349.0 0.8470873786407767 marker_or_partial_phenotype_not_definitive_etiology + 0.7034710317835261 0.7871005446497953 etiology metabolic_steatotic_phenotype 412.0 308.0 0.7475728155339806 marker_or_partial_phenotype_not_definitive_etiology + 0.9907622033849433 1.0000000000000002 etiology diagnosis_text_available_90d 412.0 412.0 1.0 marker_or_partial_phenotype_not_definitive_etiology + 0.0 0.0092377966150568 etiology diagnosis_HBV_text 412.0 0.0 0.0 marker_or_partial_phenotype_not_definitive_etiology + 0.0 0.0092377966150568 etiology diagnosis_HCV_text 412.0 0.0 0.0 marker_or_partial_phenotype_not_definitive_etiology + 0.0004285862248333 0.0136187356493737 etiology diagnosis_PBC_text 412.0 1.0 0.0024271844660194 marker_or_partial_phenotype_not_definitive_etiology + 0.0066910434088057 0.0314039047611523 etiology diagnosis_AIH_text 412.0 6.0 0.0145631067961165 marker_or_partial_phenotype_not_definitive_etiology + 0.0004285862248333 0.0136187356493737 etiology diagnosis_ALD_text 412.0 1.0 0.0024271844660194 marker_or_partial_phenotype_not_definitive_etiology + 0.4207762592248268 0.5166999124062206 etiology diagnosis_steatotic_liver_text 412.0 193.0 0.4684466019417476 marker_or_partial_phenotype_not_definitive_etiology diff --git a/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_8_longitudinal_models.tsv b/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_8_longitudinal_models.tsv new file mode 100644 index 0000000..c197f75 --- /dev/null +++ b/data/clinical_aggregate/legacy_compatible/Supplementary_Figure_8_longitudinal_models.tsv @@ -0,0 +1,38 @@ +endpoint n_observations n_groups slope_per_year ci_low ci_high p_value model_status analysis_view source analyte transform q_value_BH section index count mean std min 25% 50% 75% max +CAP 2069.0 772.0 -2.343134965830022 -3.897534167179192 -0.7887357644808519 0.0031318418260067 random_intercept_REML elastography_span_ge90d 0.0118314024538031 models +log_LSM 2069.0 772.0 -0.0841866271883629 -0.10142853364863 -0.0669447207280957 1.070429491678442e-21 random_intercept_REML elastography_span_ge90d 1.8197301358533516e-20 models +CAP 2297.0 884.0 -2.861545837489854 -4.399299964642984 -1.3237917103367234 0.000265093492786 random_intercept_REML elastography_all_distinct_dates 0.0015021964591211 models +log_LSM 2297.0 884.0 -0.0913168969050136 -0.1086679569956309 -0.0739658368143963 6.022186851867398e-25 random_intercept_REML elastography_all_distinct_dates 2.0475435296349156e-23 models +analysis_value 282.0 112.0 0.3004975809084926 0.0127510682196004 0.5882440935973847 0.0406760619605681 random_intercept_REML raw_lab_repeated_events metabolic FPG identity 0.0921990737772876 models +analysis_value 1529.0 554.0 0.0482291037567526 0.0338164327989836 0.0626417747145217 5.4306116760015884e-11 random_intercept_REML raw_lab_repeated_events metabolic HDL identity 6.154693232801801e-10 models +analysis_value 179.0 79.0 -0.0130791387675081 -0.1788072268141886 0.1526489492791723 0.8770744528835435 random_intercept_REML raw_lab_repeated_events metabolic HbA1c identity 0.931891606188765 models +analysis_value 64.0 31.0 -0.1165261839908354 -0.5401764977104514 0.3071241297287804 0.5898223510379564 within_group_cluster_fallback_after_LinAlgError raw_lab_repeated_events metabolic INS log1p 0.8914470220671642 models +analysis_value 1529.0 554.0 -0.1432818988546462 -0.1980242543582263 -0.0885395433510661 2.8976811352970546e-07 random_intercept_REML raw_lab_repeated_events metabolic LDL identity 2.4630289650024965e-06 models +analysis_value 1536.0 556.0 0.0218602234112452 -0.0472968817502968 0.0910173285727874 0.5355639394462635 random_intercept_REML raw_lab_repeated_events metabolic TC identity 0.8914470220671642 models +analysis_value 1536.0 556.0 -0.0060445660675411 -0.030720294465351 0.0186311623302686 0.6311472233306672 random_intercept_REML raw_lab_repeated_events metabolic TG log1p 0.8914470220671642 models +analysis_value 1347.0 469.0 -0.0297918509572619 -0.053416364326615 -0.0061673375879088 0.0134500249215885 random_intercept_REML raw_lab_repeated_events metabolic UA log1p 0.0381084039445009 models +analysis_value 1459.0 407.0 0.2003273092122723 0.0096956859326897 0.3909589324918548 0.0394320686480452 random_intercept_REML raw_lab_repeated_events metabolic hsCRP log1p 0.0921990737772876 models +analysis_value 163.0 60.0 0.0034000326320088 -0.0359311705967866 0.0427312358608042 0.8654573133387906 random_intercept_REML raw_lab_repeated_events LIS AFP log1p 0.931891606188765 models +analysis_value 530.0 162.0 -0.0501991400616333 -0.2965377353145926 0.1961394551913259 0.6895958871973468 random_intercept_REML raw_lab_repeated_events LIS ALB identity 0.9017792371042228 models +analysis_value 556.0 171.0 -0.0013160652394055 -0.0173580944017135 0.0147259639229023 0.8722567099351934 random_intercept_REML raw_lab_repeated_events LIS ALP log1p 0.931891606188765 models +analysis_value 414.0 127.0 -0.0848100594661939 -0.1698330677446108 0.000212948812223 0.0505765724599307 random_intercept_REML raw_lab_repeated_events LIS ALT log1p 0.1074752164773527 models +analysis_value 565.0 171.0 -0.0849679729782482 -0.1253660842049729 -0.0445698617515235 3.7506659868442266e-05 random_intercept_REML raw_lab_repeated_events LIS AST log1p 0.0002550452871054 models +analysis_value 72.0 29.0 -0.1327981415826605 -0.2290566336877399 -0.0365396494775812 0.0068517546204186 random_intercept_REML raw_lab_repeated_events LIS CIV log1p 0.0232959657094232 models +analysis_value 557.0 171.0 -0.0342549688009701 -0.0755260385455068 0.0070161009435666 0.1037861252376001 random_intercept_REML raw_lab_repeated_events LIS GGT log1p 0.2075722504752002 models +analysis_value 72.0 29.0 -0.0184151883194944 -0.1440618784609381 0.1072315018219492 0.7739142370563818 random_intercept_REML raw_lab_repeated_events LIS HA log1p 0.9073477262040338 models +analysis_value 173.0 62.0 -65.02817478990372 -107.48147013844036 -22.574879441367067 0.0026804436869852 random_intercept_REML raw_lab_repeated_events LIS HBsAg identity 0.0113918856696872 models +analysis_value 198.0 69.0 0.0468161662038515 0.0085596842238428 0.0850726481838602 0.0164625790288334 random_intercept_REML raw_lab_repeated_events LIS HDL identity 0.0430559759215644 models +analysis_value 526.0 162.0 0.0183627253824332 -0.0179711671904836 0.0546966179553501 0.321908816633598 random_intercept_REML raw_lab_repeated_events LIS IBIL log1p 0.5760473560811754 models +analysis_value 198.0 69.0 -0.1637499953770621 -0.2900097654272318 -0.0374902253268925 0.0110240760492645 random_intercept_REML raw_lab_repeated_events LIS LDL identity 0.0340744168795448 models +analysis_value 72.0 29.0 -0.0144362946992339 -0.1067502311988913 0.0778776418004234 0.7592207130081703 random_intercept_REML raw_lab_repeated_events LIS LN log1p 0.9073477262040338 models +analysis_value 159.0 47.0 -0.0018810924588533 -0.0542582065724759 0.0504960216547691 0.9438825147468058 random_intercept_REML raw_lab_repeated_events LIS LYM log1p 0.9462384472281218 models +analysis_value 159.0 47.0 -0.0100202929105785 -0.0540382511813566 0.0339976653601996 0.6554757515199736 random_intercept_REML raw_lab_repeated_events LIS MONO log1p 0.8914470220671642 models +analysis_value 159.0 47.0 0.0293618692684682 -0.081576425626951 0.1403001641638876 0.6039415910487178 within_group_cluster_fallback_after_LinAlgError raw_lab_repeated_events LIS NEU log1p 0.8914470220671642 models +analysis_value 72.0 29.0 -0.254987526360838 -0.4038863093672611 -0.1060887433544149 0.0007895949069313 within_group_cluster_fallback_after_LinAlgError raw_lab_repeated_events LIS PIIINP log1p 0.0038351752622378 models +analysis_value 159.0 47.0 -4.210328619851438 -10.862864178047252 2.442206938344378 0.2148115128933437 random_intercept_REML raw_lab_repeated_events LIS PLT identity 0.4057550799096494 models +analysis_value 200.0 70.0 0.0465020114377711 -0.1182226683875817 0.2112266912631241 0.5800575759557305 random_intercept_REML raw_lab_repeated_events LIS TC identity 0.8914470220671642 models +analysis_value 200.0 70.0 -0.0021270774186774 -0.0639530027925537 0.0596988479551989 0.9462384472281218 random_intercept_REML raw_lab_repeated_events LIS TG log1p 0.9462384472281218 models +analysis_value 159.0 47.0 0.0151619439205619 -0.0791008214131198 0.1094247092542437 0.752567598453526 within_group_cluster_fallback_after_LinAlgError raw_lab_repeated_events LIS WBC log1p 0.9073477262040338 models + delta_summary followup_years 772.0 0.862018672312997 0.44072612834687946 0.24641163062896568 0.4866629704922072 0.7980998925371499 1.1718241989910811 1.935700253940875 + delta_summary delta_CAP 772.0 -5.473267866539865 24.085312355053958 -99.99288940429702 -18.112220764159964 -3.8813934326169885 8.138683319091733 98.23562622070298 + delta_summary delta_LSM 772.0 -1.1400012040385297 2.5513980573510864 -13.371168613433841 -2.322203755378735 -0.7386698722839697 0.31894588470458474 9.671856880188 diff --git a/data/clinical_aggregate/legacy_compatible/Supplementary_single_cell_donor_burden.tsv b/data/clinical_aggregate/legacy_compatible/Supplementary_single_cell_donor_burden.tsv new file mode 100644 index 0000000..e53a69f --- /dev/null +++ b/data/clinical_aggregate/legacy_compatible/Supplementary_single_cell_donor_burden.tsv @@ -0,0 +1,11 @@ +donor disease gene_set n_genes_present burden_score_logcpm_mean n_cells +cirrhotic1 cirrhotic full_signature_v2 180 4.903940925696883 5656 +cirrhotic2 cirrhotic full_signature_v2 180 4.927346103411869 6874 +cirrhotic3 cirrhotic full_signature_v2 180 5.338565051641839 5446 +cirrhotic4 cirrhotic full_signature_v2 180 2.8926784206175733 4806 +cirrhotic5 cirrhotic full_signature_v2 180 2.833375425488283 2913 +healthy1 healthy full_signature_v2 180 3.728698917749036 3056 +healthy2 healthy full_signature_v2 180 2.3875357812923244 11247 +healthy3 healthy full_signature_v2 180 3.731392876904573 7409 +healthy4 healthy full_signature_v2 180 2.6191234498613123 8214 +healthy5 healthy full_signature_v2 180 1.965680684180866 5100 diff --git a/data/clinical_aggregate/longitudinal_outcomes.tsv b/data/clinical_aggregate/longitudinal_outcomes.tsv new file mode 100644 index 0000000..8644e5b --- /dev/null +++ b/data/clinical_aggregate/longitudinal_outcomes.tsv @@ -0,0 +1,5 @@ +outcome n +Persistent nonadvanced 442 +Persistent advanced 154 +Threshold regression 143 +Threshold progression 33 diff --git a/data/clinical_aggregate/longitudinal_state_flow.tsv b/data/clinical_aggregate/longitudinal_state_flow.tsv new file mode 100644 index 0000000..a451f3e --- /dev/null +++ b/data/clinical_aggregate/longitudinal_state_flow.tsv @@ -0,0 +1,5 @@ +state0 HH HL LH LL +HH 73 52 8 32 +HL 18 92 2 53 +LH 6 10 67 49 +LL 5 27 8 270 diff --git a/data/clinical_aggregate/serum_imbalance_associations.tsv b/data/clinical_aggregate/serum_imbalance_associations.tsv new file mode 100644 index 0000000..af23b0e --- /dev/null +++ b/data/clinical_aggregate/serum_imbalance_associations.tsv @@ -0,0 +1,5 @@ +term OR ci_low ci_high p n +Composite SDS_v0 2.2787957373766763 1.0208236597206943 5.086980462528594 0.04440303121163641 46 +ECM retention axis 2.3935357872814276 1.0245064179406684 5.591974305551597 0.04381197554410353 46 +Cholestatic-support axis 0.5780357407133115 0.2893674904308482 1.154674690804061 0.12052171864335161 46 +Portal/synthetic deficit axis 3.0851511650437407 1.2853173993983182 7.40529748965227 0.011674798572045085 46 diff --git a/data/figure_reconstruction/LAM_priority_gene_fates.tsv b/data/figure_reconstruction/LAM_priority_gene_fates.tsv new file mode 100644 index 0000000..808972b --- /dev/null +++ b/data/figure_reconstruction/LAM_priority_gene_fates.tsv @@ -0,0 +1,12 @@ +gene progression_logFC progression_FDR regression_logFC regression_FDR residual_logFC residual_FDR fate +Axl 0.400045696412429 0.0794064413706963 -0.127130435918959 0.9553743239555 0.27291526049347 0.236034467661984 partial_or_other +Cd9 0.227060110794507 0.502370443704182 0.509432957080831 0.223348361388132 0.736493067875338 0.00559473051553818 partial_or_other +Gpnmb 2.31256604940577 0.000273635988336964 0.551754488609413 0.666887328081388 2.86432053801519 2.55830926588911e-05 persistent +Lpl 2.0714526298507 4.3490987637186e-06 0.183261989270152 0.958895050253119 2.25471461912085 1.18502929318362e-06 persistent +Mertk 0.22621794735624 0.58776419757837 -0.244424245372988 0.9071932506218 -0.0182062980167482 0.977727681977691 partial_or_other +Mmp12 1.13406641706919 0.402180272195103 0.0794818213385856 0.992853100429507 1.21354823840778 0.346541150965689 partial_or_other +Mmp13 -1.36835105939596 0.0463685886878495 0.215421973856233 0.981129219113887 -1.15292908553972 0.0815011160318366 persistent +Mmp14 0.681728733685143 0.0375904031680706 0.0811611637574592 0.981587098973717 0.762889897442602 0.0147834665937223 persistent +Plau 0.699590016224927 0.615247376381877 -0.581848429035754 0.922021924637192 0.117741587189173 0.953533517907656 partial_or_other +Spp1 3.21991327267328 0.0588029809010908 -0.0257362626578536 0.995306561130045 3.19417701001543 0.0498652007852925 persistent +Trem2 1.50071709782086 1.03768240390694e-05 -0.133641606334171 0.965574707396927 1.36707549148669 3.21407577976862e-05 persistent diff --git a/data/figure_reconstruction/UQ_CODEX_scar_enrichment.tsv b/data/figure_reconstruction/UQ_CODEX_scar_enrichment.tsv new file mode 100644 index 0000000..1d229d9 --- /dev/null +++ b/data/figure_reconstruction/UQ_CODEX_scar_enrichment.tsv @@ -0,0 +1,19 @@ +sample fibrosis_stage stage_numeric patch_size outcome scar_enrichment +17P29186 F1 1 128 Vimentin 1.1572780801221756 +17P29186 F1 1 128 CD31 1.544046638589566 +17P29186 F1 1 128 CD163 1.2868022426835906 +17P29186 F1 1 128 CD14 0.7464293668808817 +17P29186 F1 1 128 CD44 1.4382336439030132 +17P29186 F1 1 128 mesenchymal_endothelial_balance -0.38676855846738994 +16P15496 F2 2 128 Vimentin 1.2242686243492504 +16P15496 F2 2 128 CD31 1.489602898021606 +16P15496 F2 2 128 CD163 0.8050862214684441 +16P15496 F2 2 128 CD14 0.49398067094964204 +16P15496 F2 2 128 CD44 1.3716968310384776 +16P15496 F2 2 128 mesenchymal_endothelial_balance -0.26533427367235596 +16P33251 F4 4 128 Vimentin 1.772459994492968 +16P33251 F4 4 128 CD31 1.2982094581860935 +16P33251 F4 4 128 CD163 1.5924120942003444 +16P33251 F4 4 128 CD14 1.131574042089161 +16P33251 F4 4 128 CD44 1.6236128241605314 +16P33251 F4 4 128 mesenchymal_endothelial_balance 0.4742505363068742 diff --git a/data/figure_reconstruction/integrated_retention_candidates.tsv b/data/figure_reconstruction/integrated_retention_candidates.tsv new file mode 100644 index 0000000..984d2e7 --- /dev/null +++ b/data/figure_reconstruction/integrated_retention_candidates.tsv @@ -0,0 +1,10559 @@ +gene_upper metadata_logFC metadata_PValue metadata_FDR supplement_swap_logFC supplement_swap_PValue supplement_swap_FDR author_AvsQ_ATAC_logFC author_MASH_ATAC_logFC author_AvsQ_RNA_logFC author_MASH_RNA_logFC author_sum_sig mouse_progression_logFC mouse_progression_FDR mouse_regression_logFC mouse_regression_FDR mouse_residual_logFC mouse_residual_FDR mouse_fate human_positive_both human_nominal_both human_fdr_any_010 author_four_way mouse_positive_residual mouse_persistent cross_species_direction functional_support evidence_score classification +ITGB5 1.05424133461338 0.0001806092990656 0.108955765289858 1.17719677021911 1.21042719671754e-05 0.0425989678098127 0.466764723588261 0.837096884456037 0.465930153485812 0.389735853712782 4.0 1.58662751475966 0.0002098827230918 -0.386468516198412 0.123719261134278 1.20015899856125 0.0025612869102069 persistent True True True True True True True 8 pathogenic_retention_candidate +GAS7 1.07711309875626 0.0492159215827199 0.399082619839385 1.23399512036119 0.0239036884350526 0.348898908348731 1.36592457612505 0.74731807988063 0.489306469996915 0.229015811175576 4.0 0.984764604933978 0.0064637643524442 -0.0711443793075217 0.798072484786645 0.913620225626457 0.011142220546085 persistent True True False True True True True human HSC knockdown validation in source study 8 pathogenic_retention_candidate +PDGFRA 0.937365343909443 0.0006635789960707 0.142837651901635 0.784895380231324 0.0040732521849441 0.252666933151519 1.02950693751959 0.9567502435360881 0.165163604665687 0.189616921066512 4.0 0.718216279417522 0.0541010386427358 0.236973023816328 0.456045215945088 0.95518930323385 0.0162164148855272 persistent True True False True True True True 7 pathogenic_retention_candidate +LAMA2 1.1858195989361 0.0035524088075787 0.21424167471499 0.993327864523985 0.0182955529481693 0.32629129734252 1.38890093232762 1.19334058502503 0.273487146630184 0.3207278078773211 4.0 1.5859683847365 0.0007344470331519 0.0679050528743566 0.828789416295883 1.65387343761085 0.0017468801289819 persistent True True False True True True True 7 pathogenic_retention_candidate +EPHA3 1.04370000694517 0.0250314023927625 0.330087379345907 1.22095541993387 0.0077154178275486 0.287862310479138 0.197530112910686 0.642974495981332 0.412151025631747 0.44603765323195 4.0 1.21785810640433 0.0048685397476733 0.0419456944124641 0.904055886651525 1.2598038008168 0.0055480039049741 persistent True True False True True True True 7 pathogenic_retention_candidate +DPYSL3 1.07076725137751 0.0272254523919376 0.333442469818192 1.04383218196513 0.0320566095748477 0.375031405408838 0.667885088960418 1.10550617159853 0.329564500167796 0.22683329701974 4.0 1.92745179728639 0.004443943068618 0.0481095999190225 0.914735097421847 1.97556139720541 0.0054112349661332 persistent True True False True True True True 7 pathogenic_retention_candidate +SVEP1 0.648878023266899 0.0272471016939557 0.333442469818192 0.732344716572826 0.0110715611820149 0.302570357129259 0.88314075040156 0.350518962474868 0.0950394853519925 0.2644014464187889 4.0 3.26397038725032 2.19248200951623e-05 -0.552978377103475 0.0703518890503919 2.71099201014684 0.0002725960561753 persistent True True False True True True True 7 pathogenic_retention_candidate +ART4 1.28427041888014 0.0025923824966387 0.205792288718135 0.950796281185655 0.03372628641496 0.376543096535729 0.294088370281929 0.2814068240495231 2.0 0.519222675439387 0.0644356815345982 0.773325546274952 0.0074780519466736 1.29254822171434 0.0017468801289819 persistent True True False False True True True 6 residual_state_candidate +LTBP2 1.81875209039086 0.004707963094979 0.221799407601324 1.86765415759983 0.0037488632661329 0.243764662040058 1.60813015044577 1.61659605968109 0.413637227704104 0.263516508082122 4.0 4.05444497329326 0.0003313871346681 -2.70192582080412 0.0020014802892984 1.35251915248914 0.0856576432905506 reversed True True False True True False True human HSC knockdown validation in source study 6 residual_state_candidate +SETBP1 0.884862880063695 0.0054632365420085 0.229265285907992 0.890022160820566 0.0051460200076148 0.265121723850427 0.9514200157917521 0.821444104220495 0.5420152848259709 3.0 1.58340331927088 0.0002635483033429 -0.50475461378502 0.0498971006576027 1.07864870548586 0.0044383732723579 persistent True True False False True True True 6 residual_state_candidate +TMSB4X 0.904208307980917 0.0081802318983977 0.252534761354631 0.836376516254334 0.0157693132922904 0.320853404849916 0.467881220463073 0.0753219872908709 2.0 0.705841380843267 0.0505999727403423 0.316231987114745 0.30529642821598 1.02207336795801 0.0104988219400673 persistent True True False False True True True 6 residual_state_candidate +PTK7 1.4992577942657 0.0088416114076308 0.258484471839641 1.80825320417199 0.0015633153652434 0.207460921631778 2.17688032869393 0.139026463449753 2.0 1.69323628916019 0.0006376029261132 -0.823816259335002 0.0154742191171605 0.869420029825189 0.0248774099173533 persistent True True False False True True True 6 residual_state_candidate +OXCT1 1.00981583767964 0.0136035863056168 0.292253024645663 0.859588141963434 0.0353250998990113 0.37720666979567 0.0610120572875744 1.0 1.15630559724161 0.0231696895801545 -0.319996836185589 0.40081978681569 0.836308761056024 0.0757902938092001 persistent True True False False True True True 6 residual_state_candidate +ABCA9 0.809226190123158 0.0138522131372605 0.294366420705352 0.695297892530096 0.038083630768848 0.379484931484566 0.184062651901247 0.3524660683094171 2.0 0.795895424703419 0.0317578786979009 0.116391624019639 0.700725230312914 0.912287048723058 0.0175042935373766 persistent True True False False True True True 6 residual_state_candidate +GALNT17 1.14326042871125 0.0159224287316726 0.29965954108556 1.22558611128103 0.0095693432060207 0.298763048903795 1.45064213452204 0.476726310916713 0.3747501618189329 3.0 5.70938316122909 5.28614004143302e-05 -1.18199997944472 0.015208253927927 4.52738318178438 0.0017468801289819 persistent True True False False True True True 6 residual_state_candidate +TGFBR1 0.742127293051646 0.0188061678101942 0.309473467285879 0.96205656249271 0.0014280175557162 0.206339143280147 0.117322039513451 1.0 1.01873173421747 0.0069674076698626 -0.290182156322375 0.296212934090321 0.728549577895095 0.0322061798655977 persistent True True False False True True True 6 residual_state_candidate +PPIL3 0.584473852672128 0.0191961801870489 0.311453903000669 0.507718510541711 0.04404596427171 0.393650849907072 0.016416209448206 1.0 0.877832194277479 0.0443436778623711 -0.132431206760716 0.694684607133917 0.745400987516763 0.0710172350507653 persistent True True False False True True True 6 residual_state_candidate +LUM 1.46134780951416 0.0245233209543114 0.32844355033163 2.10679534599419 0.0011060845888678 0.187272944881803 1.60102150399466 0.0536311810047223 2.0 1.65641616022194 0.0002548708339715 0.337990089472899 0.192410040781385 1.99440624969484 0.0003572164450804 persistent True True False False True True True 6 residual_state_candidate +PTAR1 0.367163332841084 0.026947252016496 0.333062456906093 0.356923444394509 0.030990438738857 0.375031405408838 0.0693515250785565 1.0 0.616750344625846 0.0251846901267204 0.0953806179916002 0.683573798516154 0.712130962617446 0.0138105850453239 persistent True True False False True True True 6 residual_state_candidate +ITGA8 1.72067060866081 0.0310472615664898 0.34834961489798 1.73071172319285 0.0304363214032289 0.374622380904833 0.116969715555289 1.0 1.49839884100331 0.0012760559339526 0.175150373861951 0.578630557136629 1.67354921486526 0.0018096989769756 persistent True True False False True True True 6 residual_state_candidate +CSTB 0.831242020594999 0.0320172248991519 0.352489948368348 1.01026180128614 0.0099600017323266 0.301624803148371 0.9018927157672879 1.0 0.829395537955506 0.0235068228274964 0.449173707668715 0.124893869392201 1.27856924562422 0.0038741220603223 persistent True True False False True True True 6 residual_state_candidate +LAMC1 0.580852881247806 0.0395994341516643 0.374868680542814 0.561594739552981 0.0478710630514453 0.401952804329389 0.133463715672689 0.132317774415672 2.0 0.897386108969563 0.0035237674201773 -0.327476525606484 0.152547441026677 0.569909583363079 0.0307535960382193 persistent True True False False True True True 6 residual_state_candidate +DKK3 0.960538957510942 0.0472303441027437 0.396574544678809 1.00315396971376 0.0388154808181566 0.379484931484566 0.552201586917062 0.47567757349315 0.0900485796403429 3.0 2.19737342569238 2.38853787780033e-05 -0.254295738816464 0.252424284423649 1.94307768687592 0.0002114901806361 persistent True True False False True True True 6 residual_state_candidate +PAM 0.518745896127675 0.0481125957036379 0.396735650076082 0.618781516934922 0.0167091728141251 0.325489753822016 1.12096167188297 0.155113292637663 2.0 0.838106002493556 0.0061153237733485 -0.0016953847722206 0.996065620952593 0.836410617721335 0.0077022080482086 persistent True True False False True True True 6 residual_state_candidate +SPON1 0.694240646629108 0.142535285782637 0.541326455860821 0.775069606421355 0.100039009202255 0.478125555523304 1.01143263534954 0.603429621179546 0.599131931738261 0.206398156201118 4.0 1.86113162389584 0.0362965591040473 0.303065526036047 0.586659361352075 2.16419714993189 0.0173898729115963 persistent True False False True True True True human HSC knockdown validation in source study 6 pathogenic_retention_candidate +EFEMP1 2.1034962692748 0.0001346965837505 0.108955765289858 1.99211050168461 0.0003553783518244 0.148975599106358 0.799179056901556 1.36780890154083 0.571092403139232 0.494459934927228 4.0 -1.02487965061647 0.0043053178576497 1.51371241075675 0.000803568820654 0.488832760140281 0.0876205278347447 reversed True True False True True False False human HSC knockdown validation in source study 5 cross_species_direction_conflict +RUNX1 1.15446142047313 0.000558117411864 0.138619773467801 0.946037485318587 0.006267989526373 0.27151085227822 1.33898175306207 1.44939198016898 0.250954119161802 0.225047800571109 4.0 1.31012665347493 0.0755907994361215 -0.907129895422166 0.118384518436523 0.402996758052769 0.58995516058557 reversed True True False True False False True source-study promoter/motif and perturbation support 5 insufficient_or_context_specific +FBLN5 1.40221403227944 0.0010013103814439 0.154668779872222 0.815484667165639 0.0648384897662161 0.434644301556641 0.440093978290548 0.520732094560197 0.47019459741349 0.2928244774437651 4.0 1.07506892640103 0.0013019030725492 0.525045723416457 0.0295040063362732 1.60011464981749 0.0005038150626709 persistent True False False True True True True 5 pathogenic_retention_candidate +ROBO2 -1.83035233744328 0.0010326387451326 0.154668779872222 -1.23388119923804 0.0342020107575075 0.376543096535729 1.50466840322748 0.0012190377515281 -0.628670545706997 0.0503881637611101 0.875997857520486 0.0216691742586502 persistent False True False False True True False 5 insufficient_or_context_specific +MCTP2 1.63679009013553 0.0013713895743224 0.164558653805348 2.17433440120651 5.9323623900293e-06 0.0313169410569647 1.40672723961263 0.0820574225607917 2.0 -1.23733781421638 0.0098419429663311 0.3801178324659 0.323869592406386 -0.857219981750483 0.041688969772708 persistent True True True False False True False 5 cross_species_direction_conflict +SRPX2 1.11762437291639 0.0021720286685246 0.189522964316394 0.580226397506551 0.117035767250532 0.496449831511094 0.160138767467223 0.253673324420195 0.08777073328249801 0.243833766064821 4.0 0.807181766894152 0.0097274209644883 -0.0671808635643397 0.79115826583026 0.740000903329812 0.0162324091360538 persistent True False False True True True True 5 pathogenic_retention_candidate +NEDD9 1.33213326834831 0.0030657614061873 0.212953915711243 0.862678068463747 0.0675655576089913 0.43786261079484 0.642137943993306 1.90730745655695 0.188713678009788 0.220699350055201 4.0 1.22644582314344 0.0027982430654098 -0.129034056292598 0.660792018391631 1.09741176685085 0.0066779672868489 persistent True False False True True True True 5 pathogenic_retention_candidate +ZEB1 0.70144025280107 0.0052314539331837 0.229265285907992 0.649076114398428 0.0108918339927174 0.302570357129259 0.513874894374344 0.439273739434997 0.35289238658452 0.265769373555033 4.0 0.253493489211292 0.458702547620358 0.368423268550131 0.169761918982323 0.621916757761423 0.0484099410044799 partial_or_other True True False True True False True 5 residual_state_candidate +RUNX2 1.21487516740562 0.0055832855060917 0.229265285907992 1.14898721923625 0.0091476842088099 0.296261502689003 0.729708557378345 0.197768097748593 0.140291497572323 3.0 3.09850315311935 0.0001609604703641 -1.62845375677233 0.0022845998675501 1.47004939634702 0.0198614094779529 reversed True True False False True False True source-study promoter/motif and perturbation support 5 residual_state_candidate +DLG2 0.639914555035119 0.0066306346113367 0.237387459486941 0.373432835198943 0.123034295623878 0.504414033284339 0.213995002375213 0.276586005593356 0.140334567303949 0.197042362579239 4.0 6.88248810018849 0.0019733018539092 -0.983720181962637 0.0825215987650746 5.89876791822586 0.0104682629864625 persistent True False False True True True True 5 pathogenic_retention_candidate +GSTM4 -0.873967405356779 0.0239481275459539 0.327734533946059 -0.791160506937051 0.0445408711013949 0.393650849907072 1.04642704255954 0.0179374267520533 0.507775675652544 0.129252154018286 1.55420271821209 0.0036125669112409 persistent False True False False True True False 5 insufficient_or_context_specific +NAV2 0.828106116884007 0.027285514823656 0.333442469818192 0.93666072541098 0.0109054338005674 0.302570357129259 0.455495894913333 1.57599855121453 0.7875513116739049 0.457888407963969 4.0 -0.695124537423129 0.0336593010143066 0.176582266283444 0.532089254848732 -0.518542271139685 0.0839421173172013 persistent True True False True False True False 5 cross_species_direction_conflict +SEPHS1 -0.452860007832818 0.0308026887870241 0.34708088389904 -0.546943181631055 0.0076874846409966 0.287862310479138 0.667699243195779 0.0397565105670415 0.278886831140113 0.268361780725756 0.946586074335892 0.008588523543753 persistent False True False False True True False 5 insufficient_or_context_specific +LAMC3 1.02161166845155 0.0350830742880713 0.363322396620508 1.02082643058668 0.0353581987313919 0.37720666979567 1.35214795591774 0.992139718312222 0.9723140646747471 0.489590732304293 4.0 -4.43102163243502 0.005640031554683 1.13830231029424 0.458874874484659 -3.29271932214078 0.0154495435378635 persistent True True False True False True False 5 cross_species_direction_conflict +CYTH3 0.466042438182756 0.0466540364774817 0.395461683418996 0.436101655281014 0.0635729959084873 0.432999502601999 0.442697645699912 0.4031945787348571 0.240494824475431 0.169811687967084 4.0 0.830057679973519 0.0058322247062103 0.211811797463774 0.338491977894672 1.04186947743729 0.0031776412702567 persistent True False False True True True True 5 pathogenic_retention_candidate +PDLIM3 1.00830911624397 0.0472931338452077 0.396574544678809 0.871028949058474 0.0926753377714048 0.472460751419842 0.121064141267394 0.670671322856055 0.284641055748653 0.226592996357485 4.0 1.97202835270687 0.0102133756378536 -0.138831100941615 0.785358527720079 1.83319725176525 0.0164616777115953 persistent True False False True True True True 5 pathogenic_retention_candidate +NR2F2 0.549589867783604 0.0528833402455443 0.406035451125819 0.699319110012226 0.0120883106090114 0.309429533546452 0.590507033580195 0.5154400930374 0.260317384309623 0.219964456945196 4.0 0.910193042173834 0.0085161583510793 -0.365522863599844 0.179885021706627 0.54467017857399 0.0683769392665597 persistent True False False True True True True 5 pathogenic_retention_candidate +NAV1 0.82509730219245 0.054382876946587 0.408956135898907 1.2108989804031 0.0039995580968029 0.249865883941099 1.58725924219257 1.31742647901845 0.272786968444876 0.178930540194034 4.0 1.17427185568602 0.0034486747041884 -0.500216201983628 0.0941228501027846 0.674055653702395 0.0433472156726606 persistent True False False True True True True 5 pathogenic_retention_candidate +COL12A1 0.604925129541148 0.0942319345032927 0.477507276304264 0.69448783641867 0.0502615630656626 0.405592093535716 0.129106997266805 0.282715238872008 0.106049528145743 0.139997529801878 4.0 4.05284300918579 0.0003681894616197 -1.88193402341928 0.0054451042448924 2.17090898576651 0.0217122436871925 persistent True False False True True True True 5 pathogenic_retention_candidate +TIMP3 0.704091738181341 0.144674678190048 0.544360389283866 0.0562027322872193 0.906127639738332 0.970714826340858 1.34909961397057 0.603010460745543 0.432818718941839 0.245335977437598 4.0 2.49906054996461 7.41344537805846e-05 -0.361788463134987 0.24346997836906 2.13727208682962 0.0007445766349209 persistent True False False True True True True 5 pathogenic_retention_candidate +MYLK 0.371785503486205 0.171202951003017 0.571856753217971 0.0537096772518042 0.85104556489994 0.953756403164586 0.59356325273259 0.552298066722333 0.122633799056563 0.10972883232766 4.0 1.21962730175952 0.001192131556683 -0.450931240818812 0.0852962326150015 0.768696060940711 0.0152555001528633 persistent True False False True True True True 5 pathogenic_retention_candidate +PDGFRB 0.456422650998025 0.17406932099845 0.573676192501689 0.466713576272265 0.164517250279985 0.544850245278 0.392190443503428 0.374230727666551 0.4678333656976721 0.222751117126457 4.0 1.07574196439312 0.0059817787336725 -0.295309768717577 0.324736336718888 0.780432195675548 0.0273380755274344 persistent True False False True True True True 5 pathogenic_retention_candidate +THBS2 0.708517484327018 0.188753962641228 0.586844239050912 0.987165517092523 0.0655961611065471 0.435533238803682 0.615813282216181 0.704645919824432 0.31410185624556 0.226638196708485 4.0 1.82498382666913 7.41344537805846e-05 -0.141993511702522 0.536409041578168 1.68299031496661 0.0005038150626709 persistent True False False True True True True 5 pathogenic_retention_candidate +MRC2 0.369020915889766 0.287268401114079 0.676113727797714 0.641162744611511 0.0623108635544364 0.431813959784778 0.849381856627481 0.669344688068629 0.235662915510529 0.168288728776215 4.0 2.01369266651393 7.0959212983016e-05 -0.795989920397121 0.0088771675942206 1.21770274611681 0.0027580670198418 persistent True False False True True True True 5 pathogenic_retention_candidate +ANXA5 0.075440907666975 0.800834788875892 0.938703642857403 0.32216011428697 0.287968382389989 0.648258530618693 0.314244947523502 1.14115066624503 0.0752143377778929 0.0581083093224149 4.0 0.825419830316229 0.0090378914220066 0.299333926263976 0.223325777006629 1.1247537565802 0.0031776412702567 persistent True False False True True True True 5 pathogenic_retention_candidate +GSN 1.05167852432691 3.98710333597741e-06 0.0420958370212495 0.947220067598948 6.46674296234703e-05 0.0809299418584624 1.32331349422865 0.205590632776953 0.184050528006695 3.0 -0.444759095781763 0.290889911342201 1.38699278705236 0.0042175563951795 0.942233691270601 0.0276126768019347 partial_or_other True True True False True False False 4 cross_species_direction_conflict +VGLL3 2.21971259836439 4.26481335568832e-05 0.10272882660725 1.29476156531698 0.026773859916459 0.356222495883986 0.203601719485727 0.7296935855204979 0.23133318192241 0.1771166332241811 4.0 1.03441997568168 0.0784010784296727 -0.496720894906259 0.279900373071385 0.537699080775422 0.331239321204233 partial_or_other True True False True False False True 4 insufficient_or_context_specific +ITGBL1 1.67319914332402 0.0003783012263026 0.128042361093427 1.58539567361751 0.0008894978470969 0.177355916186346 1.65631742166102 0.5774564795919069 0.474882576274119 3.0 1.11453828906682 0.117376574436309 0.479102622281935 0.317615244938999 1.59364091134876 0.0251450495418474 partial_or_other True True False False True False True 4 residual_state_candidate +SH3PXD2B 1.53390398115562 0.0004094686390761 0.128042361093427 1.23814838750013 0.0054036124678795 0.265300960238175 0.889903306747606 1.07721559157955 0.375564139505375 0.232586269729929 4.0 1.54900518341867 0.0106674786005867 -1.33858280512976 0.0112064427470806 0.21042237828891 0.721836341391194 reversed True True False True False False True 4 insufficient_or_context_specific +SYT17 -1.08456090371615 0.0009009641230162 0.148000497085406 -0.960134964360824 0.0045266079415178 0.261521011602645 -1.71612892301361 0.0052239163244238 0.60116410129804 0.219346991262779 -1.11496482171557 0.0299477689143673 persistent False True False False False True False 4 insufficient_or_context_specific +WWTR1 0.74974850993441 0.0024795734857197 0.201379514324843 0.426262051746541 0.118145840922349 0.497758894037574 1.45147172873276 0.195561095462694 0.105300695931398 3.0 0.749166344304343 0.0203837029034936 0.242812467452159 0.324028385324035 0.991978811756502 0.0063047598527459 persistent True False False False True True True 4 residual_state_candidate +NTM 2.42569448936957 0.0027742426718974 0.209978919106319 2.44046748470364 0.0027208116565754 0.224500148429329 1.50878911104258 0.168980550743592 2.0 -2.06675414078905 0.0023431287935367 0.64188992542591 0.205650792623725 -1.42486421536314 0.0145149158475532 persistent True True False False False True False 4 cross_species_direction_conflict +RNF217 0.781323332251289 0.0028427559534562 0.21136491096191 0.756730682837984 0.0041167936046432 0.252704109754786 0.791314810467051 0.354201541258096 0.363223864545122 3.0 0.17799513660831 0.541887269608551 0.267797593747338 0.239615881413648 0.445792730355648 0.0828953045195789 partial_or_other True True False False True False True 4 residual_state_candidate +FHL2 0.645991324969771 0.002982883564377 0.212953915711243 0.187236705917846 0.418511800660455 0.740369645076621 0.6574506867081129 0.7396519769500309 0.15089919898807 3.0 4.29929841758354 2.19248200951623e-05 -1.75136755207213 0.001541021056078 2.54793086551142 0.0017468801289819 persistent True False False False True True True 4 residual_state_candidate +JAM3 0.66369864416929 0.0037741337883558 0.21424167471499 0.471584125341925 0.0514368809729484 0.410669094118466 0.152132378299521 0.10930823511105 2.0 0.712725315657575 0.0478201511228984 0.29452576203059 0.285544499423019 1.00725107768816 0.010395894143059 persistent True False False False True True True 4 residual_state_candidate +UACA 0.820971689130302 0.0044529496336075 0.219692720708544 0.838251940692249 0.003565998776868 0.243710520549117 1.06978711370883 0.466708733573687 0.366442426252797 0.308832057558849 4.0 0.334864036722895 0.558807889127923 -0.533752522468701 0.228818131853734 -0.198888485745805 0.715134491056259 partial_or_other True True False True False False True 4 insufficient_or_context_specific +FNBP1L 0.750920186146915 0.0046026775099845 0.220246576897599 0.609465528340355 0.0247252495880972 0.349622129845324 0.834537268041573 0.0635441446947181 2.0 -0.644020545099929 0.0432589061898257 -0.134537273485392 0.636463789050257 -0.77855781858532 0.019483528313868 persistent True True False False False True False 4 cross_species_direction_conflict +ITIH3 -1.79939965981032 0.0057819073393307 0.23211170223823 -1.73055531795383 0.0084676007022252 0.289323392278623 -1.93755731572067 0.0004096843908995 0.730816909705527 0.0466779229560313 -1.20674040601514 0.0077833392111614 persistent False True False False False True False 4 insufficient_or_context_specific +SLC22A7 -1.63175586726651 0.006423920892137 0.237387459486941 -1.45819884700907 0.0166457347957167 0.325489753822016 -1.31939547105509 0.0125987864903197 0.315515161259899 0.471034469362023 -1.00388030979519 0.0355956608625232 persistent False True False False False True False 4 insufficient_or_context_specific +F2R 1.00280412808264 0.0070260414038026 0.240995195720413 0.669583243770214 0.0816178676295363 0.461306984171651 0.577321587344544 0.0560992149376157 2.0 1.63714512268676 0.0004096843908995 -0.103066804326521 0.727184589987579 1.53407831836024 0.0018518971868282 persistent True False False False True True True 4 residual_state_candidate +CACNA1C 1.03501832012595 0.0071912874236986 0.240995195720413 1.03518006489917 0.0071971478219604 0.28566724324909 1.28039656420785 1.30444169927218 0.599733625102067 3.0 2.55337738477533 2.19248200951623e-05 -1.67931168355886 0.0002308508183535 0.874065701216468 0.013759890655975 reversed True True False False True False True 4 residual_state_candidate +NAP1L1 0.626795185751109 0.0083959813220729 0.256198759533081 0.598790813303487 0.0126298631384623 0.313114831651016 0.235197727296616 0.177834306463471 2.0 0.60240547551866 0.118161014292752 0.209359048679237 0.48948793499822 0.811764524197897 0.0340648668645802 partial_or_other True True False False True False True 4 residual_state_candidate +PLOD2 0.948693035703378 0.0090354265515336 0.258484471839641 0.986527958000516 0.0062531408302555 0.27151085227822 0.181221680033917 0.6283491441917011 0.135840468941692 0.187529208740098 4.0 0.410390481937695 0.23564151993972 -0.890767799253962 0.0119325691705398 -0.480377317316267 0.143123095290913 partial_or_other True True False True False False True 4 insufficient_or_context_specific +IGKC 1.85466027061482 0.0091949194372543 0.259558601898396 2.01309984237524 0.0048239768455414 0.261521011602645 0.0900785051745412 1.0 0.544361964777739 0.571262460888114 1.35493067015859 0.0319042904077129 1.89929263493633 0.0219738445869506 partial_or_other True True False False True False True 4 residual_state_candidate +CNOT6L 0.443266369753769 0.0093172518012226 0.259601690244713 0.371603506825 0.032486379712451 0.375031405408838 0.420993630817276 0.188107042079834 0.188679085933336 0.483601536393655 0.609672716750612 0.0500810439963955 partial_or_other True True False False True False True 4 residual_state_candidate +UFM1 0.837208601197227 0.0096862013678775 0.265628348161172 0.887334620433422 0.0059381010488896 0.266950960575468 0.0962960426291097 1.0 0.0562012016458887 0.935525302777025 0.969386790309371 0.0364067991120958 1.02558799195526 0.0425665157431516 partial_or_other True True False False True False True 4 residual_state_candidate +VCAN 2.13101217854929 0.0099339853093277 0.2687001007293 2.17395979931039 0.0088009574259398 0.291509786412688 0.075668382747379 0.6858108836882522 0.469278956833343 0.3010057910546799 4.0 1.88903141067969 0.0566473964313001 -2.57074315511544 0.0088623098591439 -0.681711744435755 0.579050544156534 reversed True True False True False False True 4 insufficient_or_context_specific +RDH10 -0.833715097692757 0.010027262709542 0.2687001007293 -0.659138263859039 0.0493164523355254 0.404304407233699 -0.815450535767343 0.0208014659952696 -0.232621045198059 0.435052618546722 -1.0480715809654 0.0075508193403489 persistent False True False False False True False 4 insufficient_or_context_specific +EPS8L2 -1.6011919910332 0.0101931520970519 0.269890529140342 -1.56298967733881 0.012647180658335 0.313114831651016 -1.04204094092221 0.0155945474226114 0.413357158756128 0.239615881413648 -0.628683782166079 0.092933097315602 persistent False True False False False True False 4 insufficient_or_context_specific +FAS 1.09143266613469 0.0107928255145995 0.274073458004984 1.24541244959353 0.0030787064555893 0.228908329282484 0.310965822254558 0.19666417908557 0.178050799349857 3.0 -0.861793468887519 0.0687870237798535 -0.0128377112141589 0.979413650198759 -0.874631180101678 0.0559228447713581 persistent True True False False False True False 4 cross_species_direction_conflict +SELENOO -0.797824546767423 0.011839613104343 0.280904798102592 -0.794561109514015 0.0122634976393796 0.309429533546452 0.735863955610542 1.0 -0.928422188481409 0.0122547480858338 0.376948864812927 0.208992875506898 -0.551473323668483 0.0857807024700414 persistent False True False False False True False 4 insufficient_or_context_specific +ESAM -1.27112605694107 0.0127981199253747 0.29096528436151 -1.04867202688285 0.0462074182032227 0.398576733161459 -0.836421953875073 0.0100368683022182 0.307453293810833 0.236555931024969 -0.52896866006424 0.0626464989756827 persistent False True False False False True False 4 insufficient_or_context_specific +TMTC1 1.24236802771924 0.0152274538306496 0.297043416491418 1.15577734083835 0.0254474972980647 0.351006805738558 0.147091755329835 1.0 -2.19719897394668 0.0037361683913005 0.654534701152009 0.25426654722336 -1.54266427279467 0.019553149402753 persistent True True False False False True False 4 cross_species_direction_conflict +PTPRF -1.03679943863114 0.016845669302088 0.299692671530782 -1.27434275040198 0.0020717655027729 0.223491901031981 0.8442604880010881 1.0 -1.24716282896349 0.0042082508140742 0.452856949923273 0.171404608640216 -0.794305879040222 0.0330879319326839 persistent False True False False False True False 4 insufficient_or_context_specific +SRGN 1.45652190134541 0.0185837889084098 0.308502583797156 0.500001922133296 0.396857497831385 0.727749332399898 0.4713698698049729 0.6199605949251961 2.0 1.23129081469413 0.0093021391222487 0.619475438125423 0.0602567712343112 1.85076625281955 0.0021149694464937 persistent True False False False True True True 4 residual_state_candidate +ASPG -1.11098290964152 0.0190646542733007 0.311453903000669 -1.0159643534266 0.0337907129095787 0.376543096535729 -1.57304172277842 0.0011149473015342 0.71291508086673 0.0422670872513147 -0.860126641911695 0.023798422127533 persistent False True False False False True False 4 insufficient_or_context_specific +AQP1 1.03288893217 0.0196898163957523 0.313776799941556 0.925197708340503 0.0383654649499949 0.379484931484566 1.03278354463889 1.0 0.13372676209087 0.758158147574253 0.563990895366665 0.0905458158391764 0.697717657457535 0.0532821127295314 partial_or_other True True False False True False True 4 residual_state_candidate +TGFBR2 0.604147504508873 0.0212232757145215 0.321024849561486 0.493196278950295 0.0655158207201041 0.435533238803682 0.5978608975875971 0.20271629531213 0.134711571814476 3.0 0.995075681737027 0.0024287688781706 -0.284459487940264 0.220997882653384 0.710616193796763 0.0154495435378635 persistent True False False False True True True 4 residual_state_candidate +BTF3 0.694844986989429 0.0229038088444617 0.326250774279766 0.647266115068665 0.033084351520001 0.376000627931293 0.0280739922835914 1.0 0.4943417390488 0.0517930747594903 0.297844556851972 0.159907267556915 0.792186295900772 0.006838687868164 partial_or_other True True False False True False True 4 residual_state_candidate +MYO18A -0.623629361678277 0.0240184298710864 0.327734533946059 -0.71492948384821 0.0084022965287368 0.288962367265157 1.33828182456502 1.0 -0.606832049422432 0.0511659313602428 -0.236091496575051 0.381944116760868 -0.842923545997483 0.0129827441554019 persistent False True False False False True False 4 insufficient_or_context_specific +FLT1 1.60664736971059 0.0240966804944437 0.327734533946059 1.42111001560456 0.0461576863739245 0.398473305589448 0.261243093783199 0.326855370011508 0.308304910875149 0.15781882858972 0.569548004658348 0.0308076297633749 partial_or_other True True False False True False True 4 residual_state_candidate +TFR2 -1.20884895850683 0.0243514433404819 0.32844355033163 -1.17429371732762 0.0293309701019252 0.370848532095628 -1.40803831005774 0.0032080996527815 0.497702950633958 0.160863771698075 -0.91033535942378 0.0264333048593353 persistent False True False False False True False 4 insufficient_or_context_specific +GNG5 0.60241635776837 0.026740456661285 0.33175762800217 0.78267439508916 0.0034873530291761 0.243710520549117 0.0306672663042189 1.0 0.654669419683446 0.355434995341816 1.10962569883258 0.0249093491332036 1.76429511851603 0.0114369535648604 partial_or_other True True False False True False True 4 residual_state_candidate +MARCH3 1.10548282380853 0.026890505441043 0.333062456906093 1.01986519032295 0.0436147376838102 0.392214551124798 0.6461594048074549 0.275769327413465 0.160628221154627 3.0 -1.3843888743371 0.0233176113449463 -0.876503470111664 0.135814573826323 -2.26089234444877 0.0041412353303569 persistent True True False False False True False 4 cross_species_direction_conflict +MMP2 0.818015459502591 0.028666765053754 0.340071579143297 0.500527038410714 0.17404005432055 0.555912113465366 0.160338391597491 0.266565049399043 0.0366803438459049 3.0 1.7056250044593 0.0008263071357643 -0.552207918674947 0.0968725845300603 1.15341708578436 0.0088333672976549 persistent True False False False True True True 4 residual_state_candidate +RFTN1 0.388794007570509 0.0288689275682775 0.341108533371332 0.382874881186415 0.0313547890076161 0.375031405408838 0.8534188362782891 0.101323406423333 2.0 1.83026048941532 0.0001249977938437 -1.0253469434596 0.0025409329108975 0.804913545955715 0.0180289443925405 reversed True True False False True False True 4 residual_state_candidate +UBALD2 1.08353300961365 0.0303150544527775 0.344899078569424 1.0530154780079 0.0356277402062554 0.37720666979567 0.46120840934028 1.0 0.258476181792216 0.332477579525526 0.156504623809608 0.493723038434422 0.414980805601824 0.0941045021402162 partial_or_other True True False False True False True 4 residual_state_candidate +SNAP23 0.622486213614271 0.0313191153713656 0.349912402212569 0.695207239161844 0.0155390422232381 0.320853404849916 0.435696118903167 0.0810469031775166 2.0 0.335359798489702 0.448153530662287 0.546203700467657 0.104925591497567 0.881563498957358 0.033059208931182 partial_or_other True True False False True False True 4 residual_state_candidate +PRODH2 -1.37008124707005 0.0314846010716036 0.3510183929398 -1.53837047442318 0.0137187501039875 0.314756631908661 -1.22499792251753 0.0043674893756076 0.392159211619044 0.22703069622788 -0.832838710898488 0.0273197270267665 persistent False True False False False True False 4 insufficient_or_context_specific +SESN1 0.496695945560659 0.0316349286419168 0.351677425598451 0.49782134069863 0.0312076446463279 0.375031405408838 0.143328226909336 0.361544388343781 0.0560474895278397 0.108994225178037 4.0 0.651011032152938 0.155847155576129 -0.210505165228225 0.588396614941279 0.440505866924713 0.301414319774988 partial_or_other True True False True False False True 4 insufficient_or_context_specific +CBR4 0.413446965046909 0.0344572823139093 0.362711851116903 0.409994541121738 0.0360870278385779 0.37720666979567 0.316843197342313 0.06910937592584 0.131372169458474 3.0 0.201635694081108 0.598499635448072 0.37681821371453 0.194015138625939 0.578453907795638 0.0803358449379731 partial_or_other True True False False True False True 4 residual_state_candidate +ZBTB7C 1.11537684347655 0.0346564517972112 0.363322396620508 1.19698057983534 0.0239633836401373 0.348898908348731 0.0610464656242292 1.0 -1.28017648541607 0.0577091094285948 -0.0717319386695479 0.918795894770577 -1.35190842408561 0.0405196423106954 persistent True True False False False True False 4 cross_species_direction_conflict +ZMYM2 0.356865834647401 0.0362004343021181 0.366655920683396 0.450187580279782 0.0062226379882832 0.27151085227822 0.0587217049028218 1.0 0.495283217138585 0.0501810415403375 0.242079629952864 0.239615881413648 0.737362847091449 0.0088796131339789 partial_or_other True True False False True False True 4 residual_state_candidate +SHROOM1 -1.16580324799546 0.03727194081254 0.368446063719788 -1.29227267873225 0.0193717895184449 0.330467462546779 -1.23320113328829 0.0190409359930084 0.431517034029037 0.32298057334693 -0.801684099259251 0.0836848617814314 persistent False True False False False True False 4 insufficient_or_context_specific +ZKSCAN1 -0.455528018081126 0.0386576415449134 0.371584398994206 -0.531249746098359 0.0146112290483976 0.317541556275699 -0.670426739551746 0.0185736459834273 0.243348395190006 0.298131220701374 -0.42707834436174 0.0904886018943585 persistent False True False False False True False 4 insufficient_or_context_specific +MYO1D 0.457924997180453 0.0402442501286738 0.377352391526232 0.601322906852677 0.0054845184244092 0.265300960238175 0.765207009091802 0.937895288774641 0.269232810077607 0.220232367605768 4.0 0.825072752778591 0.01205975094024 -0.509128117840661 0.062121481044956 0.31594463493793 0.259043767793979 reversed True True False True False False True 4 insufficient_or_context_specific +WASHC3 0.525687691405219 0.0427564516128972 0.383949763302995 0.703895310498055 0.0051659194528331 0.265121723850427 0.0658480399823159 1.0 0.34072154129999 0.388535442251067 0.387829461616732 0.211855999793237 0.728551002916721 0.0490556441432384 partial_or_other True True False False True False True 4 residual_state_candidate +MLXIPL -1.38422242790013 0.0432842854813946 0.384202635045819 -1.48316072261344 0.0296005070308765 0.371414855918995 -1.80087468812295 0.0021799056646577 0.688404573124537 0.104171258758759 -1.11247011499841 0.0232417945936453 persistent False True False False False True False 4 insufficient_or_context_specific +PTPRC 0.941970591642294 0.0433765429981641 0.384202635045819 0.833811243522011 0.0718083606692037 0.446899163045108 0.0189925141173445 1.0 1.15959861338181 0.0647045625747953 -0.0106447126844744 0.984286094029151 1.14895390069734 0.0571375550701203 persistent True False False False True True True 4 residual_state_candidate +PCYT2 -1.11734071150168 0.0464183776745692 0.394593584128907 -1.14182849408915 0.0405163755367839 0.385380083709338 -1.26213586298857 0.004038132209842 0.512630298097751 0.125236535876845 -0.749505564890824 0.0418804103457958 persistent False True False False False True False 4 insufficient_or_context_specific +TRABD -0.440489269448426 0.0478908704117098 0.396735650076082 -0.583330326953188 0.006961763216984 0.282692791660547 -0.634988755424418 0.0372904634322189 -0.13594674975888 0.615118924661051 -0.770935505183298 0.0165299656009363 persistent False True False False False True False 4 insufficient_or_context_specific +PLEKHG5 -1.08160630753392 0.0481247507410071 0.396735650076082 -1.25835860399049 0.019929923722588 0.332176266033792 -1.09258343079862 0.0182120699787629 -0.793700843755484 0.0587550605170909 -1.88628427455411 0.0025612869102069 persistent False True False False False True False 4 insufficient_or_context_specific +PKIG 0.441043386413129 0.0484612513310931 0.396735650076082 0.29043488560836 0.209486469463159 0.581735440450297 0.7782027706370379 1.21482652392119 2.0 0.780243391962475 0.0093021391222487 -0.345058828909203 0.149195833711412 0.435184563053272 0.0898530637373285 persistent True False False False True True True 4 residual_state_candidate +GCKR -1.1555540827924 0.0485136885774135 0.396735650076082 -1.26347205083044 0.0293794753708191 0.370848532095628 -1.58816450442564 0.0035653170141041 0.743806043633252 0.0754134349371303 -0.844358460792387 0.0547868242452441 persistent False True False False False True False 4 insufficient_or_context_specific +HSP90AA1 1.01778066717747 0.0485149601307917 0.396735650076082 0.895944295576482 0.0843893490402128 0.464779732481256 0.437001678875875 0.248675727706277 0.228270664182488 3.0 1.03220909342557 0.0340998812819154 0.616872021224822 0.108069940374835 1.6490811146504 0.0045073016630279 persistent True False False False True True True 4 residual_state_candidate +CCND1 0.727353263733583 0.0601535380948727 0.420176101721702 0.95727605898904 0.013119588946883 0.313114831651016 0.602874970479322 1.0 1.61667342354456 0.0028796151718048 -0.562348921292431 0.118332923659494 1.05432450225213 0.0260082230746447 persistent True False False False True True True 4 residual_state_candidate +MFGE8 0.792689880129345 0.0679307748641496 0.433623410529439 0.838126075820954 0.0541424462379806 0.419081294430039 0.0793399063970415 1.0 0.821054866705117 0.0034194055507855 0.0435879901488933 0.848484375847446 0.86464285685401 0.0039206351226402 persistent True False False False True True True 4 residual_state_candidate +PTRH2 0.51653391497411 0.0686491291357908 0.43446260179429 0.579778737079628 0.0423917681313006 0.3908928278867 0.466467212149958 0.0405066528756444 2.0 1.04098933898318 0.0198405473148579 0.370080834585063 0.215931842222623 1.41107017356824 0.0052530463762208 persistent True False False False True True True 4 residual_state_candidate +NPTN 0.365970361216501 0.075818675921491 0.447703344731042 0.221915874368579 0.304697357045615 0.661341495477036 0.649909581525769 0.010347857272983 0.228857202234257 0.244981058203032 0.878766783760026 0.0035440769053387 persistent True False False False True True True 4 residual_state_candidate +PLXDC2 0.501550424213406 0.0833465678983863 0.459276129369083 0.447020970233377 0.126371373857902 0.508384607335028 0.170526948069974 0.116079750961617 2.0 1.03972961638175 0.0141442122680699 0.0374901671432768 0.919100420181174 1.07721978352503 0.0132066790012974 persistent True False False False True True True 4 residual_state_candidate +ALDH1A1 0.684157358430816 0.0856538508173137 0.462811339267757 0.399589985951141 0.332411597313724 0.681608398609108 0.181137824600097 1.0 0.959705373521065 0.0516488315616013 0.790898087598507 0.0716773886764753 1.75060346111957 0.0042422366782305 persistent True False False False True True True 4 residual_state_candidate +HEXB 0.385927257073474 0.0862968776978609 0.464095198907497 0.0135946352588975 0.952917636972969 0.987149466215884 1.10717977955098 0.0233545280959134 0.765481547614702 0.0349929751368232 1.87266132716568 0.0025612869102069 persistent True False False False True True True 4 residual_state_candidate +ANO4 1.18763753975531 0.0872186772890927 0.466131832446229 1.39476129732094 0.044950880671712 0.393650849907072 0.0249740876940982 1.0 3.42104034256076 0.0003401373086661 -1.61348045607259 0.0042143350509754 1.80755988648817 0.0260063020234298 persistent True False False False True True True 4 residual_state_candidate +PKHD1 1.05430527157227 0.0903143023677907 0.472516553220582 0.576302526060304 0.356231102781621 0.699607139726257 2.05324016037748 0.0363784268790505 -0.434454424140934 0.454164479532606 1.61878573623655 0.0898530637373285 persistent True False False False True True True 4 residual_state_candidate +TVP23B 0.410883779963657 0.0943888696388519 0.477507276304264 0.326083538105556 0.179278460029407 0.562350982890208 0.0190396767317956 1.0 0.501327519313003 0.0974124050266379 0.145488449134653 0.567977633923453 0.646815968447656 0.0328482704143711 persistent True False False False True True True 4 residual_state_candidate +NDUFAF7 0.451499253464423 0.106029591119402 0.493371715750834 0.345524365991235 0.210901904518643 0.583211709771565 0.0349177587243874 1.0 0.777071839527184 0.0701128786372105 0.0629832849265641 0.863351958132978 0.840055124453748 0.0445967289965206 persistent True False False False True True True 4 residual_state_candidate +PRRX1 1.33010359662029 0.106112927287097 0.493457987643623 1.95578483429462 0.0203628059302598 0.332725011651872 0.0835304053067429 1.0 3.61601609634153 0.0001230961639608 -1.79913778621032 0.0018080311366038 1.81687831013121 0.0144283092262375 persistent True False False False True True True 4 residual_state_candidate +SPARCL1 1.00714258852234 0.107456480744465 0.495746611144434 0.548838176079464 0.384408879102709 0.719298323474503 1.80810915767928 0.0002667833430675 0.157548141873124 0.590816481299231 1.9656572995524 0.0007445766349209 persistent True False False False True True True 4 residual_state_candidate +TMEM43 0.550516316493573 0.112236660900822 0.503396204669022 0.502881422841568 0.147461848000895 0.532796338690088 0.3980389470884529 0.0157116064753508 2.0 0.603457054675108 0.0205616795162199 -0.054325806084499 0.808539868452997 0.549131248590609 0.0297186931445137 persistent True False False False True True True 4 residual_state_candidate +MEST 0.894232336184564 0.112998984309644 0.504881416452792 1.12497750456397 0.047727754320629 0.401952804329389 0.441825807100373 0.0518860257181926 2.0 1.40258940456697 0.0083765006660812 -0.604774047882897 0.132879794800002 0.797815356684078 0.0812033706732052 persistent True False False False True True True 4 residual_state_candidate +MGST3 0.583274950595208 0.115057894992738 0.507484271612428 0.649737996936622 0.0783376860831212 0.457322349441485 0.0489383244904101 1.0 1.16981327807481 0.0408613478319448 0.487138602819742 0.224915513833103 1.65695188089455 0.0082417906738905 persistent True False False False True True True 4 residual_state_candidate +ACTR3 0.378237006355875 0.122984178045477 0.516672854300199 0.258638381074076 0.311374212359896 0.66389779817142 0.663291303033709 0.0825452834283036 0.0706286993449479 0.830845716775819 0.733920002378657 0.0485398789486868 persistent True False False False True True True 4 residual_state_candidate +TMEM168 0.373000022761376 0.130806795482038 0.529201783508963 0.424775889042473 0.0843035879589472 0.464779732481256 1.08971351681835 0.0060109975611172 0.0219114886093382 0.943623059068111 1.11162500542768 0.0069831467285557 persistent True False False False True True True 4 residual_state_candidate +HCLS1 0.417849875681984 0.134864070754925 0.535616764110931 0.0766161684788587 0.784411393915987 0.92544591540563 0.858027054693127 0.0515628428779546 -0.131395716864782 0.711548564069952 0.726631337828345 0.0798648203312003 persistent True False False False True True True 4 residual_state_candidate +MORF4L2 0.428131545595415 0.151216290661663 0.550531585105462 0.167490367759644 0.587288640841679 0.835274227991216 0.22246144854062 0.10868715839386 2.0 1.19735780136654 0.0310809487508784 0.712965356306073 0.0826729601006068 1.91032315767261 0.0039206351226402 persistent True False False False True True True 4 residual_state_candidate +PCDH18 0.423792050701995 0.151441670692824 0.550809250413692 0.404327627673998 0.171100012634468 0.551932151969054 0.365105492774232 1.0 1.73700653783061 0.0155945474226114 -0.375724027994885 0.442614016010504 1.36128250983572 0.0426909216456725 persistent True False False False True True True 4 residual_state_candidate +RCN2 0.336965028785548 0.156768141542426 0.556917240378512 0.307059615664799 0.193514608672154 0.570885363891703 0.471924914744743 0.574730653150503 2.0 0.968650064849446 0.0080989648790917 -0.0339025793144623 0.913650461434356 0.934747485534984 0.0110804692308603 persistent True False False False True True True 4 residual_state_candidate +RIPOR2 0.688089609962925 0.158036687438622 0.558628412442854 0.3596193069626 0.456268551515565 0.767060408474954 1.32253801921379 1.0 2.56379551089544 0.0047412157566061 -1.09128571665942 0.0447984119066693 1.47250979423602 0.0767318221897868 persistent True False False False True True True 4 residual_state_candidate +CLMP 0.766220345348006 0.159841409039029 0.561378161509638 0.822716483509083 0.133054207202532 0.519212049578983 1.93927153296173 0.375435842152969 0.0706747682714745 3.0 1.54288084593568 0.0002660197556998 -0.124563601038371 0.607673908506329 1.41831724489731 0.0017468801289819 persistent True False False False True True True 4 residual_state_candidate +SERPINH1 0.568862436292543 0.164095980578632 0.566074631457055 0.625938430513798 0.125299979088467 0.507642816276301 0.084666468565691 0.34306936706424 2.0 0.850671147536361 0.0982306692466134 -0.047443030083785 0.929241313697731 0.803228117452576 0.0978219804338098 persistent True False False False True True True 4 residual_state_candidate +HEYL 0.748661447266921 0.165694385878463 0.567066880422954 0.92715493336501 0.0890728258428113 0.470236852611986 0.8748866207545241 0.484986821423448 0.0969463882631599 3.0 0.707017456000428 0.0170520205894316 0.167739704739081 0.481904030747853 0.874757160739509 0.0072055552967273 persistent True False False False True True True 4 residual_state_candidate +VSTM4 0.436031311297119 0.169485577943589 0.571337398444576 0.503144168525974 0.111408907073252 0.489698268476019 1.05637753412714 0.0060199649903166 -0.252116685735022 0.385592878066514 0.804260848392113 0.0232417945936453 persistent True False False False True True True 4 residual_state_candidate +GPX3 0.432747398138067 0.174607547049657 0.573943487468955 0.0647589480782987 0.828612105081857 0.942913029532993 0.551525678730212 0.56564141715609 2.0 1.53206590848108 0.0023960341872129 0.977713249185484 0.0127216863333545 2.50977915766657 0.0005038150626709 persistent True False False False True True True 4 residual_state_candidate +CDC42 0.226155964823649 0.175179539508168 0.574626867390613 0.0150932317417164 0.927180979930906 0.979087152943213 0.608291302497903 0.0176553405428958 0.365989744445489 0.082130358860424 0.974281046943391 0.0027864341625554 persistent True False False False True True True 4 residual_state_candidate +KBTBD2 0.319259419694536 0.183999572416736 0.583734220425451 0.0977918413421025 0.689039388017682 0.884999569552245 0.6015267032389 0.0379613254210517 0.0704638299961615 0.778847583482528 0.671990533235062 0.0225470605348611 persistent True False False False True True True 4 residual_state_candidate +PLD3 0.2039420412576 0.189677520649504 0.586844239050912 0.0017714156579732 0.990704376534821 0.997316629238619 0.891277922755763 0.0031015678959949 -0.0288883457643062 0.904387017949864 0.862389576991457 0.0053819116927464 persistent True False False False True True True 4 residual_state_candidate +ASAH1 0.291752688760336 0.19368777398903 0.592191366457868 0.298275291850538 0.183967426964202 0.565716727964854 0.719245849606698 0.0364184770994348 0.263491337387795 0.32298057334693 0.982737186994493 0.0092897696325408 persistent True False False False True True True 4 residual_state_candidate +HTATIP2 0.447314684037738 0.213756849614179 0.612280544751707 0.604075141427121 0.0917516248210423 0.472460751419842 0.659145309924118 0.0676370022670734 0.0029075108426055 0.994381436508324 0.662052820766723 0.0568889541870215 persistent True False False False True True True 4 residual_state_candidate +PMEPA1 0.60287299587247 0.218849201906693 0.618140683181076 0.402458401297614 0.402309612117109 0.731353225024006 0.8910727556064829 0.0662281830528145 2.0 1.660928346852 0.0002548708339715 -0.333519621680876 0.198237302404241 1.32740872517112 0.0024391189527126 persistent True False False False True True True 4 residual_state_candidate +PRCP 0.375457844640428 0.226175388778887 0.624057928195541 0.526931161227157 0.0919807126573794 0.472460751419842 1.78645997042532 0.0080446784768728 0.0781975517016798 0.85914914110189 1.864657522127 0.0075508193403489 persistent True False False False True True True 4 residual_state_candidate +NABP1 0.423607760528298 0.226380549460682 0.624057928195541 0.421805783089248 0.229953306267353 0.601101016977152 0.880383103268651 0.0176553405428958 -0.251027429924466 0.377146670941356 0.629355673344184 0.0634615916668622 persistent True False False False True True True 4 residual_state_candidate +LOXL1 0.589333532032673 0.227410286751351 0.624853546501544 0.881760726141772 0.07039086562845 0.443089546602487 0.0964190572316312 1.0 1.09742666376144 0.0025918763054372 -0.0711616793859004 0.794107618541022 1.02626498437554 0.0053819116927464 persistent True False False False True True True 4 residual_state_candidate +PEAK1 0.225983721433119 0.229158432174131 0.626726990116936 0.417844834813676 0.0175022738524114 0.326204572615871 0.915754964339133 0.0024376259986037 -0.0974169190497972 0.659889891251739 0.818338045289335 0.0061222386305539 persistent True False False False True True True 4 residual_state_candidate +EIF2S1 0.294235665920806 0.237084053703658 0.634812256343697 0.312429003974935 0.210281311552804 0.582800422305635 0.0748469961567415 1.0 0.679260740617397 0.0413752607846569 0.219478504051758 0.392822900768462 0.898739244669156 0.0120082657786705 persistent True False False False True True True 4 residual_state_candidate +GTF2A1 0.308884160878223 0.2492505808795 0.647217814295563 0.244843744880237 0.358788989986606 0.70231184451666 0.533224378377417 0.045304566615673 0.115835827403042 0.601564765601474 0.649060205780459 0.0191166557187326 persistent True False False False True True True 4 residual_state_candidate +LGALS1 0.593214771287772 0.252149128126363 0.650902321456757 0.965492538538633 0.0724666908087859 0.449108979935905 0.518570496272601 0.0221883209680206 2.0 2.01491762531158 0.0054214743032507 -0.918301521283445 0.0586317228300594 1.09661610402813 0.0836389661692738 persistent True False False False True True True 4 residual_state_candidate +FBXO30 0.417365062835748 0.257607479955029 0.655993524105164 0.257650263341085 0.485677471900273 0.782071323676502 0.662687768526565 0.0875277122149622 0.022654006089429 0.949547299972159 0.685341774615994 0.0658374804641784 persistent True False False False True True True 4 residual_state_candidate +RTN4 0.2993493848094 0.258267868034476 0.656237190870052 0.434760893562976 0.0885911127882031 0.469550687157554 0.796121786339445 0.11197919232349 0.150472812266799 3.0 1.03858782524011 0.0014111110305163 0.14590657112895 0.501930350413817 1.18449439636907 0.0017468801289819 persistent True False False False True True True 4 residual_state_candidate +PLAGL1 0.259634852901501 0.267863119517542 0.664653070708863 0.431498220222629 0.053321722030728 0.416631456505827 0.150078345082753 0.0950331828495519 2.0 2.55876253789946 0.0001249977938437 -0.784972191417085 0.0262279972961886 1.77379034648238 0.0028648874599636 persistent True False False False True True True 4 residual_state_candidate +ADM 0.735305158715382 0.270036231956151 0.667222685933312 0.20854488381531 0.743880221954854 0.909384383019378 0.322810268433702 1.0 0.854851051271536 0.0103636383311129 0.0712434405570902 0.79218088890748 0.926094491828626 0.0083812906367985 persistent True False False False True True True 4 residual_state_candidate +ZBTB1 0.21665107294634 0.273517022617813 0.669025090444419 0.107823512160787 0.592550402895579 0.838902274600198 0.968522385559115 0.0036044741243049 -0.305936909748666 0.184878529111337 0.662585475810449 0.0250444073747129 persistent True False False False True True True 4 residual_state_candidate +CD36 0.545515854723911 0.282761016226399 0.674013898193165 0.27494763851608 0.58729116684311 0.835274227991216 1.64132168414252 2.14878223609549 2.0 2.49937704348167 2.19248200951623e-05 -0.272416754118125 0.25731009064251 2.22696028936355 0.0002114901806361 persistent True False False False True True True 4 residual_state_candidate +TMEM41A 0.376601983330783 0.283493180303276 0.67419136040224 0.240053471911999 0.491483051888703 0.785509848901139 1.00160761915014 0.0396203662550047 -0.21213779856169 0.564649294202046 0.789469820588449 0.0840732234422446 persistent True False False False True True True 4 residual_state_candidate +FBLN2 0.541372891930344 0.28423921319397 0.674251304622347 0.614322564347614 0.228419254585407 0.60038155150582 1.54878361787638 0.8871796188110509 2.0 1.67550502493518 0.0620942327369062 0.119161915594749 0.857530462923421 1.79466694052993 0.0396757426500509 persistent True False False False True True True 4 residual_state_candidate +COL15A1 0.862314888179111 0.290589045491291 0.678578043038158 1.03089814046363 0.215616093560457 0.587852789707652 1.45449279488581 0.9620311961396221 0.0329739834802883 3.0 2.59678771103004 0.0031456957649088 -1.28699680270225 0.0351992165901319 1.30979090832779 0.072735988371483 persistent True False False False True True True 4 residual_state_candidate +M6PR 0.217256022004461 0.300075917995967 0.685016549665172 0.212435651065839 0.31071994180626 0.66386306487225 1.01143146040068 0.0043881176122974 0.623388751151364 0.0246034988925768 1.63482021155205 0.0009293818384144 persistent True False False False True True True 4 residual_state_candidate +METTL15 0.189824111718293 0.301960106298645 0.685827631031543 0.27174436309814 0.131575119134349 0.517896578143491 1.34087151428201 0.015918700961722 -0.219743830625115 0.550684402048604 1.12112768365689 0.034615825666654 persistent True False False False True True True 4 residual_state_candidate +ANGPT1 0.436441731542804 0.305420395071481 0.690203024649979 0.356159203505265 0.405562110631702 0.733444811508554 0.2942990189601939 1.0 1.07322039486887 0.0268710692101778 -0.156096381159405 0.661987233433678 0.91712401370947 0.0465130674991153 persistent True False False False True True True 4 residual_state_candidate +TSPAN3 0.229256914884426 0.326743220134757 0.703567204687985 0.515468729424371 0.0227000103850157 0.346028040476539 0.493442206080593 1.0 0.997943284241964 0.0045748577673978 -0.139800678407816 0.596840217197595 0.858142605834148 0.0115644446219085 persistent True False False False True True True 4 residual_state_candidate +SMAD7 0.345893667504432 0.329407990289397 0.705454272104554 0.147302020877229 0.669674718892525 0.876261069841573 1.18820321896039 1.82998938342942 2.0 0.712947422674526 0.0093504465545216 -0.322755485292605 0.136640748242516 0.390191937381921 0.0962488620957426 persistent True False False False True True True 4 residual_state_candidate +CRTAP 0.325627218807322 0.344572118835369 0.714886975735193 0.563318591990018 0.10546805515003 0.482830329046451 1.0173346063138 0.0024376259986037 -0.156746331376407 0.508807794493669 0.860588274937396 0.0075508193403489 persistent True False False False True True True 4 residual_state_candidate +MYL12B 0.275592676264715 0.351285277694851 0.718364996516247 0.330707295584631 0.259855187268485 0.622885940784012 0.684484206035546 0.0302390506782496 0.805076391914945 0.0071779305864204 1.48956059795049 0.0015545129943964 persistent True False False False True True True 4 residual_state_candidate +FUT11 0.33128544081691 0.398616992285478 0.750584925468433 0.0635095693096258 0.867957343408806 0.958502690861149 0.772451128585278 0.0160014832424707 -0.277000516636487 0.257202230570591 0.49545061194879 0.0848368802853267 persistent True False False False True True True 4 residual_state_candidate +ACTA2 0.419148816649502 0.400845347773117 0.752704176206301 0.630390204194591 0.19323045745552 0.570885363891703 3.6849654896545 0.0038119192011812 -1.29057450357603 0.0937508150822434 2.39439098607847 0.032998538588555 persistent True False False False True True True 4 residual_state_candidate +CTSS 0.319057128573604 0.407078919586277 0.755880976607793 0.0400962364467262 0.919123330716618 0.975973461300015 1.50289458000499 0.004991483259635 -0.361043715793814 0.340711704421801 1.14185086421118 0.0206347977718603 persistent True False False False True True True 4 residual_state_candidate +PRDX3 0.222641467778274 0.425239137525211 0.765579345650124 0.426554786084544 0.120188247327842 0.500999836515407 0.684715040039114 0.0543153387629161 0.439744224725439 0.13040214366124 1.12445926476455 0.0064842945992413 persistent True False False False True True True 4 residual_state_candidate +STOM 0.23110517880683 0.451758484294418 0.780875918372163 0.0023427273500115 0.993833952646152 0.998542598236847 0.595944267994792 0.0718089408952681 0.252326819231594 0.366792805680118 0.848271087226385 0.0168263090542282 persistent True False False False True True True 4 residual_state_candidate +SELENOF 0.157504870668754 0.475290150328449 0.793680078545987 0.381386790741713 0.0837813153201537 0.464779732481256 0.347382915967401 0.0432748836027214 2.0 0.773670400159792 0.0332187390660312 0.156876950154006 0.596533987372648 0.930547350313798 0.0150451173382639 persistent True False False False True True True 4 residual_state_candidate +SLFN5 0.194798532185947 0.495947839179886 0.807018019139957 0.120786628863121 0.671959737403083 0.877088599168621 0.647132647317546 1.0 0.602142908708285 0.0176729331684038 0.222538315235922 0.257573616420021 0.824681223944207 0.0048935938399001 persistent True False False False True True True 4 residual_state_candidate +A4GALT 0.460895658769645 0.496638163488762 0.80743851711031 0.495236533219141 0.468688039068179 0.77300007678605 0.9344198101027359 0.024803994940925 2.0 1.10463730157364 0.0200982979210279 -0.37254223813512 0.279180135466902 0.732095063438518 0.092552405275499 persistent True False False False True True True 4 residual_state_candidate +NAMPT 0.285857475230548 0.504262716520891 0.810255529903501 0.0865265308608557 0.841255359727382 0.949538671001769 0.659901665669745 0.30843759092842 2.0 0.646758751882536 0.0654810991356768 0.167829965064352 0.548292897833149 0.814588716946888 0.0233794462872011 persistent True False False False True True True 4 residual_state_candidate +TRABD2B 0.352354311675307 0.520398471057727 0.818344810459857 0.207111169801572 0.70566683958374 0.892908735897067 0.742498395100258 0.401365265254582 2.0 1.84489183551152 0.006271558785691 -0.512581742228353 0.199927926786297 1.33231009328317 0.033540914967055 persistent True False False False True True True 4 residual_state_candidate +BUB3 0.142497941655622 0.543036924677121 0.829120218175989 0.0359402339980166 0.876445351354745 0.960605213288009 0.566336309136293 0.0773537949679076 0.0573336007780781 0.844738323412647 0.623669909914371 0.0462474680166415 persistent True False False False True True True 4 residual_state_candidate +SGCE 0.156455613477933 0.547079166239862 0.831767866942634 0.282256732873739 0.281345948915513 0.64315368591277 0.770615343352934 0.0216422663432159 0.0760168470321697 0.784431045247175 0.846632190385104 0.0149200055406564 persistent True False False False True True True 4 residual_state_candidate +URB1 0.177800952387035 0.553007171618521 0.835192232963259 0.204171771948098 0.495741567352141 0.788021600136089 0.724649960716913 0.0583179395036739 -0.0649144912120801 0.842833617448804 0.659735469504833 0.0695717269518449 persistent True False False False True True True 4 residual_state_candidate +LEPROTL1 0.130721352142712 0.593598157347459 0.857464679884317 0.280072869907078 0.250316832847243 0.616672648883528 0.5069104659809199 1.0 0.572089001391572 0.038993930039121 0.190722863943352 0.388071498887114 0.762811865334924 0.011142220546085 persistent True False False False True True True 4 residual_state_candidate +GUCY1A1 0.203242897531816 0.595739581088542 0.858279787958938 0.247526458677757 0.51796052863343 0.800840369846825 0.224354824609405 0.368911155095723 2.0 0.582910455771108 0.046943280793973 -0.0890821129081457 0.738714937413563 0.493828342862962 0.0724014783751763 persistent True False False False True True True 4 residual_state_candidate +CSF1R 0.2583511525008 0.614995644583654 0.866674321344663 0.421171280611423 0.412284334468202 0.735291083225579 0.9137681477036079 1.44645984418507 2.0 1.32282563217171 0.0302107148388683 -0.244377734109261 0.59979582169649 1.07844789806245 0.0604551190265147 persistent True False False False True True True 4 residual_state_candidate +P2RX7 0.196667425853049 0.639283250518673 0.875769113659809 0.164387064108258 0.696861072854473 0.888803059281445 0.4489600941774829 1.0 1.31678264897679 0.0095646830232615 -0.405961292604253 0.226892856442664 0.910821356372538 0.0496296269876525 persistent True False False False True True True 4 residual_state_candidate +PRSS23 0.133748086587157 0.63949703749544 0.87583470253948 0.425218497852174 0.13236840393024 0.518682589655195 0.337800876969671 0.0800833957364441 2.0 1.01269888063299 0.0023798031834875 0.597650637691669 0.0204108302344176 1.61034951832466 0.0005487571278051 persistent True False False False True True True 4 residual_state_candidate +FAM102B 0.112163053650751 0.650009565644401 0.879577786594361 0.406123107554885 0.0882031427976057 0.468622105620855 0.871215013759012 0.027362521812616 -0.259154768423554 0.388361722281788 0.612060245335458 0.0916410962775416 persistent True False False False True True True 4 residual_state_candidate +ROBO1 0.115685072515406 0.688573209997469 0.897082422402921 0.229289657067116 0.426545833206534 0.747171397205924 0.251570164332495 1.0 0.823041244060672 0.0074656227860966 -0.118173522286936 0.61498104212941 0.704867721773737 0.0173311152728257 persistent True False False False True True True 4 residual_state_candidate +EFEMP2 0.11765218749918 0.690656981105291 0.897801418588806 0.0685398447841927 0.817174457414719 0.936371599889798 0.755871648362595 1.0 0.929588619131437 0.0198132504271731 -0.330400543076358 0.306126110119931 0.599188076055079 0.0932422102479162 persistent True False False False True True True 4 residual_state_candidate +NFE2L2 0.0536168668386341 0.701746936983812 0.901539236705661 0.0907185689013985 0.510416556437888 0.796519013040946 0.881645454651845 0.0037749271380241 -0.254622544022597 0.249969917100063 0.627022910629249 0.021590288273071 persistent True False False False True True True 4 residual_state_candidate +BOC 0.148588540379385 0.727034496862812 0.912184220781648 0.0871662260972843 0.838042971447559 0.9478289694297 0.721205963115744 1.0 1.26456982797469 0.0121320074228118 0.0114945993557202 0.976949155963682 1.27606442733041 0.0131086841178374 persistent True False False False True True True 4 residual_state_candidate +GPNMB 0.183588509587846 0.72956860157916 0.913067082875205 0.669905793386401 0.220647921082606 0.5925760086083 4.50505409929146 0.0003095936560242 -0.772203963132437 0.100360595369861 3.73285013615903 0.0035440769053387 persistent True False False False True True True 4 residual_state_candidate +TMEM47 0.0959472447322961 0.750492065554048 0.919855385136123 0.170352869120744 0.574594965632937 0.829273579444496 0.523882883654299 1.0 0.850426972378275 0.004203057801367 0.322055311024548 0.132162891803226 1.17248228340282 0.0017468801289819 persistent True False False False True True True 4 residual_state_candidate +ANO10 0.0580857169754327 0.759918776376413 0.923589552317505 0.198071916721667 0.290514384583417 0.649978993946115 0.802422040089404 0.0251928879770063 -0.204758302177371 0.468164393562029 0.597663737912033 0.0711018872483116 persistent True False False False True True True 4 residual_state_candidate +TDP1 0.0839878610052845 0.760793725462318 0.924419521777892 0.0730604089554369 0.791308859017148 0.927588847807277 0.750980419649099 0.0777462296451653 -0.0343924979844221 0.929350818843529 0.716587921664677 0.0778785394803809 persistent True False False False True True True 4 residual_state_candidate +GSTA4 0.0810017044344975 0.762807571764843 0.924546245286789 0.25130964047566 0.338988009961144 0.686946959803023 0.861443040618087 0.0898697172326816 0.47806187233184 0.265802767804518 1.33950491294993 0.0153776678202828 persistent True False False False True True True 4 residual_state_candidate +LGALS3BP 0.137438186573122 0.763450539000165 0.92469397731599 0.429903025266524 0.362920749634414 0.704618844178033 0.869550495580006 0.0116352756842547 -0.237539465301634 0.392399513855511 0.632011030278373 0.0425665157431516 persistent True False False False True True True 4 residual_state_candidate +PROCR 0.105076102104886 0.767882204463775 0.92677135653674 0.267579986554687 0.448920139344207 0.763359450989875 0.955785327033568 0.0770672050412372 0.0228854625468648 0.961004759139789 0.978670789580433 0.0600338030233721 persistent True False False False True True True 4 residual_state_candidate +INTS14 0.0645525935487092 0.779510226715151 0.931741081587067 0.0982341707230066 0.670473121608138 0.876638417082195 0.576972361583028 0.0511659313602428 -0.117262841563438 0.630956157948402 0.45970952001959 0.0946745219700594 persistent True False False False True True True 4 residual_state_candidate +BGN 0.0974813766606913 0.784603141391485 0.933597104428259 0.228693937699586 0.52567145769675 0.804676662787375 0.703472684651815 0.0669338624594166 0.443677345837855 0.188872444273846 1.14715003048967 0.0089862706914021 persistent True False False False True True True 4 residual_state_candidate +KPNB1 0.040284648452702 0.810082897151071 0.941564817022646 0.0613501011979448 0.713104488068125 0.895497343705388 0.430203237116476 0.418916930761989 2.0 0.774688900120697 0.0811557520208446 0.0281789788565772 0.943918697461471 0.802867878977274 0.0607086442084818 persistent True False False False True True True 4 residual_state_candidate +UNC5B 0.0851871376371356 0.831500050770962 0.947606925285218 0.445482159680324 0.27958644004044 0.642114507827558 0.312211657407451 0.3832068620471679 2.0 1.65176459877389 0.001438452230933 -0.766293081406211 0.0398043048897253 0.885471517367675 0.0324076541158302 persistent True False False False True True True 4 residual_state_candidate +NR1D1 0.0679811727057217 0.838904668682016 0.949063086873091 0.421817814135709 0.231898904346395 0.602013433019237 0.43044982879412 0.6502701547222449 2.0 0.78509011391223 0.0667885641616118 1.13277237464561 0.0091920347644963 1.91786248855784 0.0020674151027282 persistent True False False False True True True 4 residual_state_candidate +COL14A1 0.0543387070778743 0.896897807800046 0.966901529562418 0.239952515176149 0.561387182585648 0.823211926908232 0.575495090154609 1.27785464461615 0.136440605506127 3.0 0.564965921984175 0.0897017939046924 0.246652127275705 0.399544155251953 0.81161804925988 0.0207945319748735 persistent True False False False True True True 4 residual_state_candidate +CLEC11A 0.0166465902782698 0.964410609985535 0.990394632839926 0.0629952802492766 0.866215556432237 0.958391272020028 0.268873292258811 1.0 1.88890255283947 0.0002012128726554 -0.556451576814005 0.0486550083734789 1.33245097602546 0.0035440769053387 persistent True False False False True True True 4 residual_state_candidate +SPTLC2 0.0026582972131922 0.989833096278198 0.998150694622828 0.245219808480937 0.249190223974425 0.615185358140767 0.821904659886341 0.0194474699731699 -0.259209176575624 0.339328394740848 0.562695483310717 0.0791498522610979 persistent True False False False True True True 4 residual_state_candidate +NOX4 3.72334783637011 3.68104850746672e-05 0.10272882660725 4.22130253055488 2.87420473217806e-06 0.0303458535623359 0.49451489011736 0.116515309564505 2.0 -2.32319833634057 0.0017521462155667 2.26163300852715 0.0019014954372257 -0.0615653278134145 0.910083688098381 reversed True True True False False False False 3 cross_species_direction_conflict +KLF8 1.3779404470724 5.3583487365974e-05 0.10272882660725 1.42944783209204 2.45766001873928e-05 0.0648699361946232 0.0277331923943788 1.0 True True True False False False False 3 insufficient_or_context_specific +FBXL2 1.47290499312528 5.83797082443168e-05 0.10272882660725 1.43676854376763 0.0001066919675165 0.0938711494199632 0.162327788551418 1.0 True True True False False False False 3 insufficient_or_context_specific +DEFB1 3.68382110619091 8.42938620146075e-05 0.108955765289858 4.15149736791588 4.80652511901502e-05 0.072496131723658 True True True False False False False 3 insufficient_or_context_specific +SMOC2 1.71835011319586 0.0001519634504277 0.108955765289858 1.23266837896414 0.0095764435600909 0.298763048903795 0.552991065100155 0.55154477741853 0.31077190697296 3.0 0.19245357299408 0.584876029901657 0.275441405570139 0.326146528483505 0.467894978564219 0.12139975557953 partial_or_other True True False False False False True 3 insufficient_or_context_specific +NALCN 1.54169808858761 0.0001618654255431 0.108955765289858 1.34817412583108 0.0012185352936821 0.187272944881803 0.9732001905210731 1.43723385519284 0.450046334341433 0.442845499495388 4.0 True True False True False False False 3 insufficient_or_context_specific +MYO1E 1.6753341957841 0.0002057470289387 0.108955765289858 1.29408243483913 0.0080017621342252 0.287862310479138 0.332253998830514 2.20460509878654 0.673671950099909 0.6096156523255071 4.0 -0.572989430225154 0.175099670205399 0.75347177404287 0.0482294932783469 0.180482343817715 0.654720546855689 partial_or_other True True False True False False False 3 cross_species_direction_conflict +LINC00924 1.4653136344555 0.000208054590126 0.108955765289858 1.57894905404112 3.94549794529477e-05 0.0694276121773704 1.10546207178589 0.355541239473055 0.293003605878903 3.0 True True True False False False False 3 insufficient_or_context_specific +MAX 0.637133222495839 0.0002096279007917 0.108955765289858 0.533512429932118 0.0028107263782283 0.224500148429329 0.32845342609399 0.0661575925509265 0.0640967543545081 3.0 0.0266025282464709 0.928084729396159 0.0614186620407648 0.766965481751459 0.0880211902872357 0.692860349728178 partial_or_other True True False False False False True 3 insufficient_or_context_specific +SRGAP1 1.30706723454004 0.0002270341765842 0.108955765289858 1.11836095296388 0.0022471642125698 0.223491901031981 0.286042026860455 0.349816470428402 0.188742155487796 3.0 0.316293338598894 0.702993905795963 -1.27014458301376 0.0609704407064964 -0.953851244414864 0.224182575843922 partial_or_other True True False False False False True 3 insufficient_or_context_specific +FYN 0.651993802394511 0.0002912285769304 0.122991652609267 0.606944120091161 0.0008348585754023 0.177355916186346 0.8417223958230409 0.103328300807497 2.0 0.0671018957714355 0.908949182532723 -0.565476832889678 0.153219444725113 -0.498374937118243 0.242890421248834 partial_or_other True True False False False False True 3 insufficient_or_context_specific +EDIL3 2.70091952536343 0.0003099286233661 0.125854861749994 2.83975003313253 0.0001528655384295 0.11191244956391 0.452774513300681 1.13587021762985 0.373364962523918 0.261073085990445 4.0 True True False True False False False 3 insufficient_or_context_specific +AKR1B10 3.47000693743901 0.0005093139241623 0.138619773467801 3.44166817802477 0.0005624287948644 0.169660663319394 0.133690464484602 0.768408825074034 -0.103299920036033 0.76487523923077 0.0303905444485689 0.942235319114133 partial_or_other True True False False False False True 3 insufficient_or_context_specific +SLC6A6 2.09109264961386 0.0005535013884511 0.138619773467801 2.02167717493068 0.000878451692122 0.177355916186346 0.630762649517081 0.446316779944296 0.127935907495184 3.0 0.284541089318466 0.449455014610277 -0.337970973163349 0.27599909330465 -0.0534298838448821 0.891738589459061 partial_or_other True True False False False False True 3 insufficient_or_context_specific +SPP1 3.50499688836716 0.0005903527939985 0.138619773467801 2.94604936672011 0.0025193024972614 0.224500148429329 1.18495650363599 0.382327866974021 -1.11631667830408 0.303030596115823 0.0686398253319131 0.963970358036666 partial_or_other True True False False False False True 3 insufficient_or_context_specific +KALRN 2.02359070428823 0.0006867816547602 0.142837651901635 1.9698156109601 0.0010269725660331 0.186944419865129 0.48275636195765 1.35981478252982 0.93032555539344 3.0 0.0970293879249478 0.885130826731918 -0.824192081878157 0.088346677370223 -0.727162693953209 0.143345918951258 partial_or_other True True False False False False True 3 insufficient_or_context_specific +COL8A1 2.37621258523319 0.000794603440312 0.146549458248405 1.84908563705518 0.0091994125048655 0.296778539969839 0.3525882684256571 0.4344581991177779 0.309319797462709 3.0 1.93026218685107 0.0124390230859606 -0.81178845985768 0.118332925269519 1.11847372699339 0.11152866013593 partial_or_other True True False False False False True 3 insufficient_or_context_specific +NAA38 0.817704341841792 0.0010389845683283 0.154668779872222 0.75609513128703 0.0027150821053434 0.224500148429329 0.798215052896095 0.348063050032582 0.0497459480597879 3.0 -0.0087419876629552 0.989165574768777 1.09964183156978 0.0146965476533192 1.09089984390683 0.023257696200555 partial_or_other True True False False True False False 3 cross_species_direction_conflict +DOK5 1.70249978292275 0.0010454388326126 0.154668779872222 1.76114175405676 0.0006869824597365 0.172694304997579 0.9317710782716508 0.103805603380552 2.0 1.01727592006927 0.172593300098147 -0.773466093814263 0.169904376486525 0.243809826255009 0.767490593138392 partial_or_other True True False False False False True 3 insufficient_or_context_specific +ERG 1.58511001951162 0.0010953456676033 0.154668779872222 1.42954078301379 0.0038866451841301 0.246357651018449 0.42053180480464 0.4107163619074211 0.3833268151371571 0.324166230585177 4.0 -0.0988029295876472 0.922603819289352 0.612774757525267 0.306310744415245 0.51397182793762 0.459569101050868 partial_or_other True True False True False False False 3 cross_species_direction_conflict +TPBG -1.15863201974529 0.0013090692646694 0.164558653805348 -1.35692091000186 6.89874480702938e-05 0.0809299418584624 False True True False False False False 3 insufficient_or_context_specific +NPNT 2.19652784098979 0.0013562504399984 0.164558653805348 2.16712774229727 0.0016644543435656 0.20851373013042 0.475270150709401 0.985812794455 0.360695951569221 0.230192206369198 4.0 True True False True False False False 3 insufficient_or_context_specific +LPAR6 0.939280323158815 0.0014154599009195 0.165917455862169 0.715365263950429 0.0219408232066075 0.344844446816731 1.5149283759546 0.0309698959323526 2.0 0.276892966501293 0.52712314267036 0.207304625477214 0.541412917233681 0.484197591978507 0.195619592462982 partial_or_other True True False False False False True 3 insufficient_or_context_specific +CFAP69 0.925686208640258 0.0014221685175572 0.165917455862169 0.92409634916377 0.0015130568876951 0.207460921631778 0.393722999499666 0.0540535090453937 2.0 0.535583032814122 0.494607655857145 -1.79765707656269 0.0189780648895102 -1.26207404374857 0.120029026418899 partial_or_other True True False False False False True 3 insufficient_or_context_specific +CCNG2 1.1316785049829 0.0015241783714539 0.166011993302809 0.858922372251238 0.0194902852486244 0.330467462546779 0.491300191678552 0.05833334210591799 2.0 0.429619065523708 0.165942573661498 -0.713689722414688 0.0190874425109485 -0.28407065689098 0.329992453274922 partial_or_other True True False False False False True 3 insufficient_or_context_specific +TANK 0.908828228441235 0.0015306862599365 0.166011993302809 0.644669228323361 0.0366120015085383 0.377876708853838 0.8954012996553171 0.562083383595703 0.140765843187003 0.2559976013115089 4.0 -0.0490152585728208 0.909541120529428 -0.203121950383743 0.484087042604894 -0.252137208956564 0.41748284034273 partial_or_other True True False True False False False 3 cross_species_direction_conflict +DTNA 1.78244191323455 0.0016275652651906 0.173155493600382 1.85317405165897 0.0010226021026053 0.186944419865129 0.27326023714337 1.34957933439391 2.0 0.838376169958776 0.323630168411968 -0.935689530541774 0.155973798885351 -0.097313360582998 0.922845826959116 partial_or_other True True False False False False True 3 insufficient_or_context_specific +STXBP4 1.12466029619412 0.0017144088348108 0.174045466133974 0.989491647806281 0.0067764347527549 0.282692791660547 0.146259851013419 0.185881140748899 2.0 0.28954821959916 0.322611567357763 -0.183625003571352 0.448035375093149 0.105923216027808 0.715134491056259 partial_or_other True True False False False False True 3 insufficient_or_context_specific +RPS4X 1.00663741923808 0.0017780773931724 0.175448047823497 1.23199344188148 0.000103760538797 0.0938711494199632 0.521051099471976 0.0295269100852599 2.0 True True True False False False False 3 insufficient_or_context_specific +FAP 2.63919054167441 0.0019076447319026 0.179665930369822 3.58115842535328 3.12496224994454e-05 0.0659867028698289 1.35896825090011 0.187094391812482 2.0 -0.0553638493829708 0.956587192113681 -0.52679558692107 0.434091539512716 -0.582159436304041 0.448599088574639 partial_or_other True True True False False False False 3 cross_species_direction_conflict +TANC2 1.49955745998736 0.0021137405490991 0.188353911748976 1.58455144907463 0.0010564384257615 0.187272944881803 0.366586703838218 0.321442641123271 0.316028104976225 3.0 0.340988708633918 0.777628685353503 -0.0674081334428015 0.94005956267517 0.273580575191117 0.797349700931942 partial_or_other True True False False False False True 3 insufficient_or_context_specific +RIC1 0.52812332296148 0.0023560419301695 0.200605570151053 0.493714491029181 0.0050256852719059 0.265121723850427 0.0809401459806662 0.10758174032241 2.0 0.189031198792756 0.476536353860324 -0.356790975239831 0.108926755655765 -0.167759776447075 0.480868747884856 partial_or_other True True False False False False True 3 insufficient_or_context_specific +UBE3B 0.479308624641053 0.0025842252923142 0.205792288718135 0.336015191246688 0.0431232130216384 0.391483132487066 0.139235561722311 0.661386573767127 -0.489813328699529 0.0585135033049198 -0.350577766977218 0.188758850947986 partial_or_other True True False False False False True 3 insufficient_or_context_specific +HILPDA 2.22500060720887 0.0026426355823985 0.208098062369754 2.30960018957075 0.0019231713149063 0.223491901031981 0.26742917723244 0.0946382079890339 2.0 0.649812757603291 0.158372243800118 -0.304421743777816 0.41373661094645 0.345391013825475 0.426303153214734 partial_or_other True True False False False False True 3 insufficient_or_context_specific +ULK4 0.638401575372937 0.0028222086791259 0.211325384639803 0.725420665580419 0.0003809756749262 0.148975599106358 0.506616185921916 1.0 1.37368986566271 0.0381895867019911 -1.44828297289949 0.0134136082408191 -0.0745931072367808 0.927074750236329 reversed True True False False False False True 3 insufficient_or_context_specific +FASN -2.60690339585559 0.003104733785982 0.212953915711243 -2.63199981532689 0.0027662535828191 0.224500148429329 0.3305299613835639 1.0 0.436860791217754 0.267520124318704 0.217577262780362 0.529334266629754 0.654438053998117 0.0796964443580893 partial_or_other False True False False True False False 3 insufficient_or_context_specific +MPP6 0.726820095744466 0.003508580460638 0.21424167471499 0.639623464752268 0.0108817648598557 0.302570357129259 0.0550027541720999 0.122947119990626 2.0 0.240255486707111 0.554655679612985 -0.406275184731238 0.220878659684542 -0.166019698024127 0.655316934567585 partial_or_other True True False False False False True 3 insufficient_or_context_specific +MOB3B 1.03586490909229 0.0037218981979076 0.21424167471499 0.970992421183057 0.0070619871019395 0.283499847232994 0.43872041630057 0.743191902871814 0.270250628227877 0.187956348442939 4.0 -0.937709024180526 0.0227583114293402 0.430644888878722 0.208589517138224 -0.507064135301804 0.155902903061034 partial_or_other True True False True False False False 3 cross_species_direction_conflict +SLC39A10 0.674369625348508 0.0037472685078791 0.21424167471499 0.68741929370031 0.0030663575566528 0.228908329282484 2.17359971110739 0.052561473954491 2.0 0.296995419201293 0.599714475679788 0.282424836880567 0.483004732971773 0.57942025608186 0.217469018887659 partial_or_other True True False False False False True 3 insufficient_or_context_specific +GNAS 0.470443260643238 0.0040436675593417 0.21424167471499 0.446441382288647 0.0066880390974525 0.28094846198463 0.490229460075783 0.112618531781383 0.165650994855684 3.0 0.0355117978650536 0.937042962477951 0.40316402814504 0.189228298852976 0.438675826010093 0.172318973292997 partial_or_other True True False False False False True 3 insufficient_or_context_specific +SOX4 1.48671197657269 0.0041224144048247 0.21424167471499 1.34127224165864 0.0111009365504026 0.302570357129259 0.5055188135683389 0.0428396218480985 2.0 1.55669908941704 0.0023758671660028 -1.62754031889359 0.001897059711468 -0.07084122947655 0.87846803337313 reversed True True False False False False True 3 insufficient_or_context_specific +ASAP2 0.936475015396559 0.0042487554986193 0.214633304088148 0.801646325020379 0.0171730884434043 0.326204572615871 1.00259961175203 0.671351585477148 0.322234659541839 0.199229228940928 4.0 -0.221904286379893 0.507755048168404 -0.164954407183984 0.552527294409907 -0.386858693563877 0.187156648302077 partial_or_other True True False True False False False 3 cross_species_direction_conflict +GREB1L -1.15285451431392 0.0045596799741069 0.220246576897599 -0.414528712912668 0.341652727996733 0.68904861550898 1.96880047143677 0.0081741894099227 -0.554131731574981 0.228503450900886 1.41466873986179 0.0400325339094177 persistent False False False False True True False 3 insufficient_or_context_specific +STK17B 1.77616270132843 0.0045873469643067 0.220246576897599 1.47471126135977 0.0199568408829972 0.332176266033792 0.5817554062621441 0.0627488468311377 2.0 1.11831943133812 0.0745648639460987 -0.513420859548499 0.264516599933226 0.604898571789623 0.312983626018603 partial_or_other True True False False False False True 3 insufficient_or_context_specific +SLC25A16 -0.564728760971041 0.0046100493202842 0.220246576897599 -0.517186268653254 0.0104499158025548 0.302245517751671 0.438288070557881 1.0 -0.25219256630738 0.494754870527973 0.920609201582961 0.0088771675942206 0.668416635275582 0.0451284273131162 partial_or_other False True False False True False False 3 insufficient_or_context_specific +TMSB10 1.24108856581022 0.0046746926296256 0.221799407601324 1.46664700965564 0.0007820437179241 0.177355916186346 0.332654317850471 1.0 0.581332116348848 0.128871924761007 -0.348091254155916 0.296462026858219 0.233240862192932 0.521594863745992 partial_or_other True True False False False False True 3 insufficient_or_context_specific +TMEM123 0.619381587352472 0.004761664979373 0.221799407601324 0.555056394923182 0.0134562446350366 0.313114831651016 0.0872817441264258 0.839459113675983 0.404308405434024 0.165649341568736 0.49159014956045 0.12442619052867 partial_or_other True True False False False False True 3 insufficient_or_context_specific +TXNIP 1.03916717196127 0.0048922141237826 0.224573898777816 0.593911639245999 0.110557851673158 0.487854032604514 0.31687552449152 1.02385165092602 0.0389728746343317 0.0665581650638556 4.0 0.0716996055580634 0.922409786806701 1.18925401116208 0.0310568195353952 1.26095361672014 0.0302335587355037 partial_or_other True False False True True False True 3 residual_state_candidate +FDPS -1.02035590859438 0.005109873589608 0.227474198558781 -1.068762494452 0.0028982508913635 0.226664688229747 0.5655707471222379 1.0 -0.0202716036030545 0.969903069983214 1.08458585234052 0.0115451970965235 1.06431424873747 0.01796365661322 partial_or_other False True False False True False False 3 insufficient_or_context_specific +WDR78 0.631942464543105 0.0057303374738557 0.231589375580443 0.569998364419485 0.0135295557700652 0.313114831651016 0.0483021364620007 1.0 0.203248425051572 0.814653406210822 -0.751088532183135 0.211864650655882 -0.547840107131562 0.443529638632892 partial_or_other True True False False False False True 3 insufficient_or_context_specific +REV3L 0.455150542262301 0.0059103277954958 0.232609124179994 0.434284311719491 0.009259102235737 0.29713556658028 0.19254922289266 0.207505075214702 2.0 0.117276141874217 0.806498198498477 0.42400739319139 0.186551101599249 0.541283535065607 0.133467274422914 partial_or_other True True False False False False True 3 insufficient_or_context_specific +USP45 0.550833463081946 0.0065650903048067 0.237387459486941 0.47375027696847 0.0201960782177799 0.332725011651872 0.28727660283741 0.0573502461877475 2.0 0.281756069576038 0.317990669807999 -0.406391741178441 0.0924586291954733 -0.124635671602403 0.654166388964995 partial_or_other True True False False False False True 3 insufficient_or_context_specific +KDM3A 0.721726856040143 0.006849436412474 0.240253653298676 0.584124277240583 0.0321389997581409 0.375031405408838 0.109082905750158 1.0 0.18007669405494 0.468839098744151 -0.383842949998226 0.0716773886764753 -0.203766255943286 0.353484309849452 partial_or_other True True False False False False True 3 insufficient_or_context_specific +LAMP2 0.790989045934438 0.0073079080448087 0.240995195720413 0.913702380639353 0.0016040300008238 0.207460921631778 0.0390570648885657 1.0 -0.158885203726705 0.65674314972199 0.686291513888769 0.0278525669242175 0.527406310162064 0.0836293666307456 partial_or_other True True False False True False False 3 cross_species_direction_conflict +FZD6 1.41464526757233 0.007313948416169 0.240995195720413 1.38493838373307 0.0088357056696299 0.291509786412688 0.605049479828342 0.02715978673414 2.0 0.241157805332483 0.781810193990744 0.6982691869232 0.182337786833112 0.939426992255683 0.143012060467827 partial_or_other True True False False False False True 3 insufficient_or_context_specific +OSBPL8 0.695914083242568 0.0073270939407324 0.240995195720413 0.799351979077179 0.0015798089161457 0.207460921631778 0.636826003680537 0.8964731101739849 0.336479798467326 0.277525515733801 4.0 -0.342339517433953 0.227557768765451 0.069345147711673 0.795174898320345 -0.27299436972228 0.295237617665077 partial_or_other True True False True False False False 3 cross_species_direction_conflict +INTS12 0.732258561298434 0.007562619996851 0.245680436697702 0.715138227839028 0.009375402911534 0.297984207800093 0.0906787960288959 1.0 0.572184689391895 0.323507330193364 -0.229222176950233 0.620120034133893 0.342962512441663 0.536286158093099 partial_or_other True True False False False False True 3 insufficient_or_context_specific +NPAS2 0.85984148154708 0.0077616413416848 0.246996184097737 0.390602806224395 0.271969983001213 0.635912471173671 0.4159427353418089 0.561905170548053 0.214108803252712 0.0891403280025828 4.0 -0.946360666875474 0.0385908394070961 -0.0581830696959143 0.900171868249892 -1.00454373657139 0.0280523116727348 persistent True False False True False True False 3 cross_species_direction_conflict +IFITM2 0.627411681027816 0.0085084683028047 0.257399450833847 0.583520902846377 0.0134700261247894 0.313114831651016 -0.0364152532863245 0.933221450786296 1.2802575841823 0.0021058852436703 1.24384233089598 0.003720919926498 partial_or_other True True False False True False False 3 cross_species_direction_conflict +MEX3B 1.81120858301501 0.0088087705593383 0.258484471839641 1.64278337743952 0.0165745431332889 0.325489753822016 0.264740847422637 0.522597232145995 0.0356479856010744 3.0 0.834902531593565 0.0619409095287294 -0.903489339090088 0.0228832164823849 -0.0685868074965223 0.893263686360097 reversed True True False False False False True 3 insufficient_or_context_specific +DEPTOR 1.21853960453243 0.0089967113632406 0.258484471839641 1.07829512347845 0.0212747575955652 0.338791690337824 0.0701461607350984 0.8765872711123369 0.6278633279666811 0.292938759270685 4.0 -1.45224861488012 0.0058322247062103 1.50581462945841 0.0043195488060681 0.0535660145782902 0.911849057329971 reversed True True False True False False False 3 cross_species_direction_conflict +DEPP1 1.89438135111389 0.0093326153016241 0.259601690244713 1.72319810268406 0.0184109568346568 0.327267058068343 0.7579324856552009 1.09232462212892 0.4164972695533379 0.320943777289688 4.0 -2.83732132963585 0.0163990157203634 1.54736300836705 0.110268054345557 -1.28995832126879 0.175731906315342 reversed True True False True False False False 3 cross_species_direction_conflict +CSRP2 1.29065503330857 0.0099297752093465 0.2687001007293 1.38338662714899 0.0063143944589369 0.272111741622269 0.327861937567942 0.0644834863424726 2.0 0.904505078695437 0.0180843412313611 -0.613604878196026 0.0565201777239656 0.290900200499412 0.387115334382997 reversed True True False False False False True 3 insufficient_or_context_specific +LXN 1.35360075738968 0.0099360413703225 0.2687001007293 1.55092130655342 0.0027965041778561 0.224500148429329 0.238980125648019 0.206426465652433 2.0 0.114548065005241 0.921831517302813 0.201053697593097 0.781867685848205 0.315601762598337 0.718197076469477 partial_or_other True True False False False False True 3 insufficient_or_context_specific +EEF1A1 0.555620028857262 0.0101174054073943 0.26906691761025 0.45849796941932 0.0350118646403344 0.37720666979567 0.0161201117365043 1.0 -0.423533701544196 0.488522479960615 1.37799976332483 0.0189376862160248 0.954466061780629 0.0840732234422446 partial_or_other True True False False True False False 3 cross_species_direction_conflict +U2SURP 0.352538233156802 0.0107286579603722 0.274073458004984 0.273191023440857 0.0471699804454159 0.400982812836313 0.0692163050124869 0.108544515460865 2.0 0.0202450212645803 0.950911927418656 -0.416057362992559 0.0725045060515146 -0.395812341727978 0.101975987082887 partial_or_other True True False False False False True 3 insufficient_or_context_specific +PRR16 1.58311848277336 0.0107699681602173 0.274073458004984 1.82403354031204 0.0027641074772205 0.224500148429329 0.552004660596848 0.44671380268152 0.7082513404987758 0.544302139151704 4.0 -1.19948659785845 0.0160389064445087 0.76777227955531 0.0692144239550952 -0.431714318303137 0.299324753590232 reversed True True False True False False False 3 cross_species_direction_conflict +GEM 1.79738872882966 0.01090402725846 0.274106475701954 2.10589357297645 0.0023284816360596 0.223491901031981 0.583375466139724 1.93559524179687 0.520263799982214 0.565011204580444 4.0 -1.12437090534135 0.0200260836162985 0.985840592478177 0.0262246748551629 -0.138530312863178 0.761123905375912 reversed True True False True False False False 3 cross_species_direction_conflict +SLK 0.4304615362774 0.012173148956325 0.286245226460756 0.346543226147664 0.0467636533699529 0.399450754777127 0.251259616653179 0.0438597422674705 0.0680626467276056 3.0 0.0562345479469 0.879840540577828 -0.0614995893442261 0.825327546884421 -0.0052650413973261 0.987346287125091 partial_or_other True True False False False False True 3 insufficient_or_context_specific +VAMP7 0.617600714297905 0.0122959801817637 0.287634085018266 0.651788581650712 0.0078727228977436 0.287862310479138 0.030351504585779 1.0 -0.0419134675852354 0.930095922530229 0.996160404188092 0.0055158894556795 0.954246936602857 0.0125670450878044 partial_or_other True True False False True False False 3 cross_species_direction_conflict +DTWD1 0.590288476967912 0.0126096240693353 0.289418284617483 0.485693333062535 0.0419074614914216 0.3908928278867 0.610926215881422 1.05025235609663 0.0880663008251478 0.08113284639716001 4.0 -0.402416476064708 0.407124560143836 0.172595106982104 0.674608220210568 -0.229821369082605 0.608119365637099 partial_or_other True True False True False False False 3 cross_species_direction_conflict +SIPA1L2 1.17903927171441 0.0132237470336512 0.292253024645663 1.00606650618934 0.0370426868914987 0.379484931484566 0.0571531841364411 1.0 0.204441024633061 0.701769001297478 -0.582428762739115 0.147951421998344 -0.377987738106054 0.409795575950342 partial_or_other True True False False False False True 3 insufficient_or_context_specific +MITF 1.05436564167737 0.013513969653069 0.292253024645663 0.872221331807813 0.0449652325239562 0.393650849907072 2.65550350737257 0.248008073906559 0.231349909826161 3.0 0.0443549130506081 0.949213952797514 -0.361182970191345 0.419375599823061 -0.316828057140737 0.545436765316864 partial_or_other True True False False False False True 3 insufficient_or_context_specific +TMEM164 0.582432991699052 0.0135350152835093 0.292253024645663 0.527187090287447 0.0269592269059796 0.356222495883986 0.3667737120718689 0.100075698061834 0.102237096725026 3.0 0.58233084572181 0.0385854918613753 -0.486848421550109 0.0471682533736356 0.0954824241717007 0.732945190435209 reversed True True False False False False True 3 insufficient_or_context_specific +SULF2 1.20273783631788 0.0135894223846248 0.292253024645663 1.18564598564321 0.0151485267210119 0.320500116612027 0.7413724181308441 0.245395678369947 0.163181767964927 3.0 0.030737798055748 0.952376258663084 -0.113068733664936 0.750475104138033 -0.0823309356091876 0.843188603495081 partial_or_other True True False False False False True 3 insufficient_or_context_specific +MOB3A -0.875212904402467 0.0139407929175904 0.294366420705352 -1.22027721324014 8.06179360478485e-05 0.0851164168793185 0.37353844709539 0.315626341928965 2.0 0.927659647383434 0.0723788904168593 -0.252430455314424 0.518375431310415 0.67522919206901 0.163435298492889 partial_or_other False True True False False False False 3 insufficient_or_context_specific +TFDP1 -0.631849610257905 0.0144197976307797 0.296448024722276 -0.766783800640321 0.0018353458959558 0.222395268370307 0.959385389483793 0.001965696939265 -0.511997652951622 0.028360679669742 0.447387736532171 0.0656999624831582 reversed False True False False True False False 3 insufficient_or_context_specific +SORT1 1.04736444282594 0.014518300164565 0.297043416491418 0.975361492214049 0.0238602055412655 0.348898908348731 0.8652229247100219 0.146526838683869 0.126667377894519 3.0 1.04480404056906 0.0259946798413385 -0.398445551286806 0.259825333612605 0.646358489282256 0.128794237013735 partial_or_other True True False False False False True 3 insufficient_or_context_specific +RAD21 0.502167007514222 0.0147307352678157 0.297043416491418 0.470181930493437 0.0230956381620313 0.346051520554005 0.0769908035795639 1.0 0.224163445360481 0.570188014127236 0.21333960326614 0.482746145075091 0.437503048626621 0.189710077525785 partial_or_other True True False False False False True 3 insufficient_or_context_specific +DCLRE1C 0.583641404676475 0.0148886215026848 0.297043416491418 0.473810936053647 0.0499317948420073 0.40534943521819 0.0501748604818486 1.0 0.0198334437216997 0.97167108654619 -0.275054863491867 0.465787572977052 -0.255221419770167 0.557422362455443 partial_or_other True True False False False False True 3 insufficient_or_context_specific +ELP2 0.484532114539531 0.0150539210774189 0.297043416491418 0.435497348603246 0.0306153600845877 0.375031405408838 1.34982639628281 0.110262572143853 0.128005458377008 3.0 0.171395381308851 0.623281942230427 -0.43114581257239 0.113916446776431 -0.259750431263539 0.386565081530086 partial_or_other True True False False False False True 3 insufficient_or_context_specific +AKAP13 0.571408259171726 0.0150990745091623 0.297043416491418 0.485405855843672 0.0425546783065106 0.391369593693501 0.909230701068182 1.81671802400742 0.289367133642567 0.26363537587702 4.0 -0.0386543656513216 0.908173535814737 -0.127678068860929 0.583640071363598 -0.166332434512251 0.494463446475076 partial_or_other True True False True False False False 3 cross_species_direction_conflict +PARD3B 0.526903734958638 0.0151175060936619 0.297043416491418 0.476026703226461 0.0291901801779239 0.369532280957458 0.257170964890385 0.263854068284367 0.172375832965365 3.0 0.0264272151812234 0.947515172143523 -0.10950271175418 0.683917409876099 -0.0830754965729562 0.790801227508984 partial_or_other True True False False False False True 3 insufficient_or_context_specific +MTHFD2 1.44451515319981 0.0151191509762498 0.297043416491418 1.82609541160988 0.0023244604831043 0.223491901031981 0.315999154025586 0.0502444962227066 2.0 0.98884865504117 0.37857428312758 -0.698592724986832 0.386349867850376 0.290255930054339 0.812320116507902 partial_or_other True True False False False False True 3 insufficient_or_context_specific +PGD -0.91345585055025 0.0153247657719735 0.297043416491418 -0.612597153763808 0.118666397918367 0.498956522987703 0.33121727139549 1.0 1.26346917856022 0.0006690048699659 -0.384401184740754 0.0989224158856885 0.879067993819465 0.0072055552967273 persistent False False False False True True False 3 insufficient_or_context_specific +ABAT -0.912483125840435 0.0154019935757682 0.297043416491418 -0.99122179297759 0.0075785818155378 0.287862310479138 -0.763445566330217 0.060785961500358 1.64761123835376 0.001541021056078 0.884165672023541 0.0275068867800109 reversed False True False False True False False 3 insufficient_or_context_specific +PRELID2 0.926341307481273 0.0154407913224661 0.297043416491418 1.03709663348251 0.0061543989072688 0.27151085227822 0.108586624798222 0.273441626467653 0.149807730843217 3.0 0.764949529411988 0.304923685818963 -0.983985586961036 0.0973787424355556 -0.219036057549048 0.79581818670263 partial_or_other True True False False False False True 3 insufficient_or_context_specific +MAML2 0.642018178863103 0.0157095456019291 0.298311838966128 0.698134757385374 0.0075391523089855 0.287862310479138 0.159008810509836 0.22582364864921 2.0 0.239432023564709 0.684618554469955 0.137164884051464 0.7597613918515 0.376596907616173 0.434833800585178 partial_or_other True True False False False False True 3 insufficient_or_context_specific +AFF1 0.593079622874573 0.0157554590144583 0.298352700419085 0.528891756802985 0.0341982270758114 0.376543096535729 0.0960997591495372 1.34186951903193 0.279796564312545 0.257885739926601 4.0 -0.126437876494432 0.731372920904862 0.339310257741875 0.222510336581085 0.212872381247443 0.477096550569562 partial_or_other True True False True False False False 3 cross_species_direction_conflict +PRDM6 1.30505323828947 0.0162095573228302 0.299692671530782 1.47615898807428 0.006436544045396 0.275129684337212 0.198783812014708 0.469658401440745 0.107801905606698 3.0 0.940808843868631 0.0572592820937919 -0.77221379601384 0.0531957753796503 0.168595047854791 0.747504020879527 reversed True True False False False False True 3 insufficient_or_context_specific +ARSK 0.779639411347885 0.0164257922076536 0.299692671530782 0.79940197774176 0.0139581538751582 0.314756631908661 0.0297191448350727 1.0 0.559720997692209 0.250603432874197 0.108557041295364 0.786145531578765 0.668278038987572 0.136194608934765 partial_or_other True True False False False False True 3 insufficient_or_context_specific +KCTD18 0.981663101328749 0.0166161164685596 0.299692671530782 0.992515175432358 0.0157681701204295 0.320853404849916 0.433283051124663 0.0334928861403367 2.0 0.234199128228964 0.533088705499102 -0.936038827315881 0.0102860264387742 -0.701839699086917 0.0496938829356209 partial_or_other True True False False False False True 3 insufficient_or_context_specific +RANBP9 0.506821915643647 0.0167623896167603 0.299692671530782 0.582472191631209 0.0054959815707863 0.265300960238175 0.200941520150397 0.142808833345006 0.179139715536429 3.0 0.170443961181953 0.5445306236067 -0.369329792943699 0.109641829754189 -0.198885831761746 0.417328850343201 partial_or_other True True False False False False True 3 insufficient_or_context_specific +SLC35F5 0.505468301622764 0.0168518776054976 0.299692671530782 0.593548512218256 0.0041865680880942 0.254033252149992 0.065874406538657 0.103909717577442 2.0 0.311279606409224 0.319299600821284 -0.0876486562472165 0.752578366649604 0.223630950162007 0.43540349362075 partial_or_other True True False False False False True 3 insufficient_or_context_specific +SBNO1 -0.312979814461036 0.0169114686549422 0.299692671530782 -0.215175240684187 0.109528807479206 0.485461724087018 0.550131781510568 0.0493520010005205 -0.118731129592679 0.61498104212941 0.431400651917889 0.0959104164518342 persistent False False False False True True False 3 insufficient_or_context_specific +NAV3 0.926747684140363 0.0170696010573622 0.301372655457575 0.91276795462475 0.0190153218841388 0.330467462546779 0.4918439853670399 0.616974127921426 0.4179258757849971 3.0 1.49258793527938 0.00704193274823 -1.29077478720551 0.0061345825413023 0.20181314807387 0.713216351079149 reversed True True False False False False True 3 insufficient_or_context_specific +LMOD1 1.18389035764657 0.0182410997780404 0.308143250330481 0.747047418169677 0.157552147794683 0.54100292051313 0.442609797989042 0.7581928251533181 0.50020324269018 0.320457391217562 4.0 1.90685156700094 0.0009638872987954 -1.00666209530042 0.0111048708005583 0.900189471700515 0.0483722882746632 reversed True False False True True False True 3 residual_state_candidate +BDH1 -1.15481138077086 0.0184840408148148 0.308385251700923 -1.09470791657455 0.026408586331872 0.354273049744177 0.0443526407161424 0.949204716243156 0.976790131188203 0.0470467636611634 1.02114277190435 0.0489007947299594 partial_or_other False True False False True False False 3 insufficient_or_context_specific +HECW2 0.609065760567316 0.0186835595637502 0.309473467285879 0.627274798098504 0.0151181999712374 0.320500116612027 0.224676699186406 0.597847856752033 -0.402470114164773 0.220991920965177 -0.177793414978367 0.64859526869157 partial_or_other True True False False False False True 3 insufficient_or_context_specific +CSGALNACT2 0.488365737326776 0.0193707690053549 0.312583300557302 0.445971208560835 0.0346263001015983 0.37720666979567 1.21263617972554 0.114457042608503 0.107704137112251 3.0 0.229604541389166 0.625040275548432 0.187085360022186 0.598785192422713 0.416689901411352 0.285210305339473 partial_or_other True True False False False False True 3 insufficient_or_context_specific +KCNS3 1.08270674932233 0.0197780646570025 0.313776799941556 1.09924499110948 0.0181915210275274 0.32629129734252 1.22029115517911 0.9685356877346291 0.0998464001357029 3.0 1.12800513484138 0.227814282822524 -0.209008960776723 0.757422335555981 0.918996174064653 0.297064923830832 partial_or_other True True False False False False True 3 insufficient_or_context_specific +PGAM1 0.860343135740809 0.0208856898689892 0.31919574035472 0.901732031104158 0.0160547110623954 0.322306608081226 0.0262502922336617 1.0 0.0396688941633603 0.917825730068964 -0.255488245285969 0.322929027124992 -0.215819351122609 0.430680157497176 partial_or_other True True False False False False True 3 insufficient_or_context_specific +LGALS3 0.88653736962017 0.0210622774571787 0.319964784737976 0.791124058154612 0.0393207850595166 0.379484931484566 0.251253406596026 1.06230180995615 0.0394546532257444 3.0 0.543706834678749 0.475432627002284 -0.356684656006215 0.54363135591074 0.187022178672533 0.805886381300348 partial_or_other True True False False False False True 3 insufficient_or_context_specific +SNX2 0.492341059422328 0.0217039209336556 0.32491939960396 0.469907930085669 0.0299627994654899 0.372611586285798 0.0702353658987459 1.0 0.0196707632836588 0.956647651462224 0.158532931952908 0.51809378108216 0.178203695236567 0.499636520430242 partial_or_other True True False False False False True 3 insufficient_or_context_specific +POLK 0.382534144103413 0.022512213305243 0.325508705713526 0.459495121249829 0.0049034373603967 0.262794373863292 0.0749344406123568 0.104307347278729 2.0 0.603847990487064 0.145429855379514 -0.692067987918834 0.057557260400652 -0.08821999743177 0.844293963005993 partial_or_other True True False False False False True 3 insufficient_or_context_specific +AKT3 0.514310130516019 0.0225987764053812 0.325508705713526 0.497425958862308 0.0276167675337468 0.361656300887855 0.253457232219362 0.16814927334315 2.0 0.386799441734879 0.229141235706913 -0.473158151213658 0.0930553355954398 -0.0863587094787786 0.796915694271842 partial_or_other True True False False False False True 3 insufficient_or_context_specific +ARL3 0.589754927742233 0.0230091501643025 0.326250774279766 0.654790531142716 0.0110869708131996 0.302570357129259 0.141115901177397 0.661232702910979 0.219426764857491 0.367046419544836 0.360542666034888 0.173586821040604 partial_or_other True True False False False False True 3 insufficient_or_context_specific +ROR2 0.928410971069194 0.0230681394772198 0.326250774279766 0.968797739803754 0.0172621961317662 0.326204572615871 1.21354572384335 1.04990146053985 0.618895091686749 0.4810018139130079 4.0 True True False True False False False 3 insufficient_or_context_specific +BTBD2 -0.591990713057919 0.0239463738106121 0.327734533946059 -0.74154940642858 0.0023524921398475 0.223762270382979 0.308380836103935 0.270361512914888 0.346659902183598 0.129843046496044 0.655040738287533 0.0225896267849194 partial_or_other False True False False True False False 3 insufficient_or_context_specific +ZC2HC1A 0.680780393258466 0.0251331975892867 0.330087379345907 0.889040217361819 0.0022293044514448 0.223491901031981 0.111345308461893 0.0994376656671179 2.0 0.0653122653602936 0.910001897483017 -0.742591994138115 0.068871070498288 -0.677279728777821 0.114382032462266 partial_or_other True True False False False False True 3 insufficient_or_context_specific +ALDH3A2 -0.492512655284133 0.0254060747991632 0.330087379345907 -0.450772702156573 0.0428586785878367 0.391483132487066 0.576611209610844 0.286992276176639 0.49590082173227 0.275082590491085 1.07251203134311 0.0422357246427118 partial_or_other False True False False True False False 3 insufficient_or_context_specific +B2M 0.553680528464196 0.0255178390124972 0.330087379345907 0.522082440954973 0.0368875379924178 0.378850803622517 -0.124353338429283 0.714820944325319 1.40787816030176 0.0009226106283564 1.28352482187247 0.0024201480685987 partial_or_other True True False False True False False 3 cross_species_direction_conflict +CDC42EP3 1.05198059253241 0.0255539939988588 0.330087379345907 0.422762186910946 0.375163315892527 0.712918338587708 0.4877262440733521 0.396827798488208 0.043689554181378 0.1136596106446 4.0 0.3887631559245 0.415741600019983 0.696983039945539 0.0779409362225741 1.08574619587004 0.0225896267849194 partial_or_other True False False True True False True 3 residual_state_candidate +CYP7B1 0.803394302167381 0.0262429446684064 0.330935942403272 0.718462174110027 0.0491918605006942 0.404177169779245 0.5393026587079699 0.628216280723319 0.5472695023257179 0.349349122215259 4.0 -2.50256081484186 0.0001685754482938 2.91419887446231 0.000157183914281 0.411638059620444 0.271383588047378 reversed True True False True False False False 3 cross_species_direction_conflict +IGSF11 1.55932865399722 0.0263707421914595 0.330935942403272 1.61115631015002 0.0229092201752241 0.346028040476539 0.0586324615740868 1.0 0.646555300353112 0.387973493862955 0.166309788243281 0.776037429532659 0.812865088596393 0.220670709896878 partial_or_other True True False False False False True 3 insufficient_or_context_specific +ACSS2 -0.643585478825848 0.0270763631060717 0.333184430855367 -0.793151892628747 0.0036090402771873 0.243710520549117 0.4352031308112529 1.0 -0.175901127199179 0.573619496442142 1.50549833945993 0.0004751224120538 1.32959721226075 0.0017468801289819 partial_or_other False True False False True False False 3 insufficient_or_context_specific +PDCD5 0.758048351604412 0.0272867166326872 0.333442469818192 0.768816319093776 0.0255326034104198 0.351006805738558 0.204489300444325 0.582183418340244 0.26345454308217 0.339426330143911 0.467943843526495 0.136118347096935 partial_or_other True True False False False False True 3 insufficient_or_context_specific +MOXD1 1.63931798866283 0.0289362839560757 0.341108533371332 2.0987691513535 0.0052499217568671 0.265208966071784 0.323034784726005 1.23007263109167 0.3289030836501289 0.263427446554939 4.0 True True False True False False False 3 insufficient_or_context_specific +STEAP2 1.34203924672856 0.0291857623036571 0.342001418870157 1.4958838724659 0.0152089449874022 0.320500116612027 0.11677140885376 1.0 0.654562363137584 0.272355044708177 -0.225070369454556 0.639641145924403 0.429491993683028 0.442967053498642 partial_or_other True True False False False False True 3 insufficient_or_context_specific +WSB1 0.415837554426718 0.0292885303984312 0.342330691391477 0.41321635699845 0.0301937153976678 0.374450197630696 0.309217113717217 0.192187342984952 0.175555745018305 3.0 0.209615223150074 0.467993048120536 -0.669606395928582 0.0160287499754662 -0.459991172778508 0.0808853782484586 partial_or_other True True False False False False True 3 insufficient_or_context_specific +WDR41 0.598633102392724 0.0295980169783624 0.342436744765113 0.608463535862714 0.026969169383818 0.356222495883986 0.0648077681900032 1.0 0.180415337279657 0.591406277572281 -0.304230588919763 0.240844966547172 -0.123815251640106 0.690565147347938 partial_or_other True True False False False False True 3 insufficient_or_context_specific +HIC1 0.923048076308314 0.0296000977029964 0.342436744765113 1.15293652741464 0.0074221583470724 0.287862310479138 0.847478808083058 1.53528275478313 0.0265424956153736 3.0 0.789840760023528 0.0090352782412501 -0.620742972940779 0.0199738478640665 0.169097787082749 0.512805829615744 reversed True True False False False False True 3 insufficient_or_context_specific +PIAS2 0.44086876139335 0.0320790451713471 0.352695607872978 0.47628498406847 0.0192441760607652 0.330467462546779 0.0879828948146115 0.063589672221605 2.0 0.289428624319368 0.214082877414911 -0.572580179639438 0.0146965476533192 -0.28315155532007 0.193506662678034 partial_or_other True True False False False False True 3 insufficient_or_context_specific +POLH 0.479725479632147 0.0331000249743167 0.35660210579473 0.592479917017014 0.0088819916530537 0.291509786412688 0.0257292774638392 1.0 0.404547408591049 0.653396314246701 -0.540188859708951 0.399931774709963 -0.135641451117902 0.882695739947302 partial_or_other True True False False False False True 3 insufficient_or_context_specific +GALNT11 0.360292834254176 0.033324201844667 0.356792055793388 0.363125432079846 0.0316085194128951 0.375031405408838 0.0916669547938285 0.822505711803127 -0.311116089515819 0.277960288637706 -0.21944913472199 0.489020069427108 partial_or_other True True False False False False True 3 insufficient_or_context_specific +SEC22B 0.594744196300544 0.0334118869357068 0.356792055793388 0.726005541989493 0.0068785269952684 0.282692791660547 0.0570017919603447 1.0 0.0285657749892203 0.93061952943084 0.129106209716303 0.560115782996674 0.157671984705523 0.503055010189903 partial_or_other True True False False False False True 3 insufficient_or_context_specific +MLLT3 0.78476764934113 0.0335555889929644 0.356792055793388 0.82275974601759 0.0254218475213317 0.351006805738558 0.169260318953142 0.127528701856282 2.0 0.693178367541204 0.230964269362116 -0.310298087610025 0.500085839365991 0.382880279931179 0.49010159619798 partial_or_other True True False False False False True 3 insufficient_or_context_specific +MAP3K5 0.798975289781289 0.0339396280428884 0.359052698273362 0.824652006934381 0.0282237469854977 0.366526839696045 0.343898888481379 0.450407546303332 0.325875181135973 3.0 0.0415388680535473 0.930095922530229 0.232520617292724 0.443010312880798 0.274059485346272 0.406845565740702 partial_or_other True True False False False False True 3 insufficient_or_context_specific +P4HA1 0.576539359921419 0.0343174172620994 0.361961330123122 0.574104648765121 0.0352007927176302 0.37720666979567 0.343439830216376 1.33142916434538 0.131871221608922 3.0 0.0873234202178788 0.855224142933824 -0.0938461381841207 0.795293688669723 -0.0065227179662419 0.987814594556054 partial_or_other True True False False False False True 3 insufficient_or_context_specific +GLRX 0.772438736029271 0.0348669759339759 0.363322396620508 0.920705153220824 0.0115670404322454 0.303878173051996 0.3743955527378089 0.0455079405923092 2.0 -0.211144669077754 0.573573228483649 0.933136309478865 0.006803635808275 0.721991640401111 0.0312028350588248 partial_or_other True True False False True False False 3 cross_species_direction_conflict +C11ORF96 0.805576559882766 0.0358641551566639 0.365370955427964 0.845166010499464 0.0269566757459388 0.356222495883986 0.236678532354146 0.380019941742828 0.122753180272532 0.131748312086309 4.0 True True False True False False False 3 insufficient_or_context_specific +FBXL7 0.583262313025175 0.0358865013050576 0.365370955427964 0.668199769317436 0.0135403653373763 0.313114831651016 0.264338656161 0.204423314340148 2.0 0.210416592091415 0.809937727594474 -1.11374583963223 0.0873532582513399 -0.903329247540811 0.221730432895975 partial_or_other True True False False False False True 3 insufficient_or_context_specific +PKD2 0.500177536180927 0.0364150853372349 0.366820534891745 0.494216983089897 0.0388899015847829 0.379484931484566 0.481507958238978 0.572047865497321 0.209919671432442 0.165236206155256 4.0 -0.166930078354515 0.634311843602184 -0.268515123021424 0.337510803118271 -0.435445201375939 0.142143060877176 partial_or_other True True False True False False False 3 cross_species_direction_conflict +FADS1 -0.678834014025737 0.0367472734369244 0.368100296913708 -0.740822239708253 0.022226077634124 0.346028040476539 -0.42554797760933 0.301132840267642 1.09243487987895 0.0094583642610821 0.666886902269618 0.0803358449379731 partial_or_other False True False False True False False 3 insufficient_or_context_specific +FBXO11 0.329035509806216 0.037061359161591 0.368139714899329 0.32490891129556 0.0391156904011802 0.379484931484566 0.124043279646023 0.692852686185376 -0.0486102861656739 0.857823368160146 0.075432993480349 0.792871789850276 partial_or_other True True False False False False True 3 insufficient_or_context_specific +COX6B1 0.770070395201393 0.0376189186224094 0.368446063719788 1.01967456395019 0.0048952782728615 0.262794373863292 0.0149949263195864 1.0 0.0302666398660672 0.954740159227753 0.281250858599435 0.432360617148621 0.311517498465502 0.409824865936315 partial_or_other True True False False False False True 3 insufficient_or_context_specific +RNMT 0.426204569293374 0.0380711430145665 0.369783926354916 0.46833572507747 0.0214281760612888 0.340208545646748 0.113482594160641 0.131873280358151 2.0 0.175902898612779 0.565034087534571 -0.700099639662771 0.0140633070958152 -0.524196741049992 0.0612083840157598 partial_or_other True True False False False False True 3 insufficient_or_context_specific +NTRK2 -1.11098065063784 0.0383646335639152 0.371268378705607 -0.698164568293283 0.203429894160017 0.576835372560841 2.48208321228364 0.0112869169448235 -0.411607489912329 0.446065886285473 2.07047572237132 0.0297966330138298 persistent False False False False True True False 3 insufficient_or_context_specific +PDK1 1.08974005862404 0.0392192083364478 0.374084143383926 1.13028126637122 0.0329229788494404 0.375130164525249 0.2654096104298639 0.0678117612636193 2.0 -1.13239797346346 0.0482270359169932 2.00115986765627 0.0019705767786685 0.868761894192815 0.0699673784309596 reversed True True False False True False False 3 cross_species_direction_conflict +WDPCP 0.318989542395061 0.0401545026095389 0.377180817216648 0.357515620503773 0.0193304156695558 0.330467462546779 0.134036342312043 0.788755922871072 0.116996589983659 0.750468167229035 0.251032932295703 0.530928784133368 partial_or_other True True False False False False True 3 insufficient_or_context_specific +ABCD1 -0.790867442355834 0.0404836540595651 0.377731883491073 -0.779773777571983 0.0439678022716854 0.393650849907072 -0.0174606409007134 0.965819679450514 0.698108169921177 0.0189376862160248 0.680647529020464 0.0309732872687645 partial_or_other False True False False True False False 3 insufficient_or_context_specific +RAB31 0.821464677554639 0.0410664327514368 0.37999947150716 1.15313072931512 0.0031186504552445 0.230256723821483 0.998636639910498 0.244482291165718 0.190803977425003 3.0 0.944865073009191 0.0052362596317565 -1.01361107449802 0.0033471189363927 -0.068746001488831 0.824153930186941 reversed True True False False False False True 3 insufficient_or_context_specific +ABCC2 -1.25790767959238 0.0424582155255045 0.383730849135154 -1.50774222017353 0.013494091787412 0.313114831651016 0.250362174681539 0.598468161484001 0.515053274069641 0.163733290139426 0.76541544875118 0.0657491136101928 partial_or_other False True False False True False False 3 insufficient_or_context_specific +SELENBP1 -1.24820182480367 0.0433112788220045 0.384202635045819 -1.41226807218568 0.0210455504777508 0.336665033248625 -0.242780640560772 0.561447014082597 0.869769178731663 0.0215432160676674 0.626988538170891 0.0859928881823508 partial_or_other False True False False True False False 3 insufficient_or_context_specific +HNRNPF -0.378191950069819 0.0437184882536666 0.385082844493601 -0.429979385451746 0.0199304613564668 0.332176266033792 0.412457567433042 0.456699649785881 0.836736891687131 0.0587279866310067 1.24919445912017 0.0212309424842446 partial_or_other False True False False True False False 3 insufficient_or_context_specific +C1QTNF1 -0.847841553321916 0.0437677034847814 0.385082844493601 -1.04259907837641 0.0108736262440367 0.302570357129259 0.350863022396901 1.7467816126247 2.0 0.100773954001657 0.777586261152974 0.599848710430143 0.0367242725469514 0.700622664431799 0.0254704154406573 partial_or_other False True False False True False False 3 insufficient_or_context_specific +HSPB1 1.66243500889394 0.044631539537152 0.389376026269853 1.85903638670034 0.0250914969385149 0.351006805738558 0.399817483024917 1.35390524279873 0.211273871609251 0.287991550465896 4.0 -0.8031896282479 0.11349892391157 0.884678766118774 0.0545766224767442 0.0814891378708736 0.877788154471087 partial_or_other True True False True False False False 3 cross_species_direction_conflict +PARP8 0.509209982617576 0.0457903725054293 0.392939221707042 0.62142811726158 0.0125793106423898 0.313114831651016 0.132734882372394 0.106410851064096 2.0 0.104646654881312 0.83289069999139 -0.777704177637238 0.0393462191412386 -0.673057522755926 0.0898530637373285 partial_or_other True True False False False False True 3 insufficient_or_context_specific +STK38L 0.722592823528383 0.0458143760107377 0.392939221707042 0.8879669977397 0.0117308297451085 0.305645553145081 1.15595166176376 0.15010947782039 0.2077475222518 3.0 0.328335304053131 0.31738191177615 -0.223888119297338 0.407205620653328 0.104447184755793 0.752267014939348 partial_or_other True True False False False False True 3 insufficient_or_context_specific +LOXL3 1.09805454547318 0.0461089995103212 0.393661071168746 1.14251345761918 0.038885692738992 0.379484931484566 0.0599804804511206 1.0 1.10687331938704 0.0275359444143067 -0.651761804263411 0.113319981192221 0.455111515123633 0.310100188256524 reversed True True False False False False True 3 insufficient_or_context_specific +BICC1 0.880851125062694 0.046137394249117 0.393661071168746 0.990617479729656 0.0231680353549276 0.346051520554005 0.740491286971327 0.425634708377745 2.0 0.443032316342671 0.217914028425351 -0.481372156428475 0.128505314543313 -0.0383398400858043 0.922505202223034 partial_or_other True True False False False False True 3 insufficient_or_context_specific +GAB3 0.695742842342761 0.0467365888827941 0.395461683418996 0.695330155277296 0.0472127507029636 0.40102350918897 0.0277744867094041 1.0 0.621864960803893 0.292673545271475 -0.155233501020041 0.743309603870169 0.466631459783853 0.395544454729015 partial_or_other True True False False False False True 3 insufficient_or_context_specific +CD164 0.42263516246258 0.0470381879205086 0.396352105398826 0.584292898139452 0.0044852286353075 0.261521011602645 -0.667135787067672 0.0286734115323082 1.13773277361454 0.0020014802892984 0.470596986546871 0.0872179798562124 reversed True True False False True False False 3 cross_species_direction_conflict +ANPEP -0.883412658108404 0.0475366920251185 0.396574544678809 -1.02545650181284 0.0195653613014259 0.330467462546779 -0.0995587978549284 0.772311419223825 1.02668417025508 0.0025337729375146 0.927125372400149 0.006351445639828 partial_or_other False True False False True False False 3 insufficient_or_context_specific +PYGB -0.518456064859448 0.0542801750121493 0.408770140133979 -0.428302930695501 0.115554067088248 0.493786316225751 0.871030613686731 1.0 0.9004839170961 0.0054359758108851 -0.425179171214305 0.0770072031495656 0.475304745881795 0.0830265328654727 persistent False False False False True True False 3 insufficient_or_context_specific +OLFM2 -0.451617149813811 0.0802185615120336 0.454127384688499 -0.446884170845705 0.0837063856866684 0.464779732481256 0.472779785023479 1.0 2.59295794737712 0.0319575485426957 -0.265192299075446 0.694525645115653 2.32776564830167 0.0496938829356209 persistent False False False False True True False 3 insufficient_or_context_specific +HMGCS1 -0.78962409804243 0.0931740471764439 0.476139327220794 -1.05258018668756 0.0202447420196923 0.332725011651872 0.722046115855332 0.0943933077117905 0.354789110622701 0.330327995439636 1.07683522647803 0.0192337276192522 persistent False False False False True True False 3 insufficient_or_context_specific +UBE2V2 -0.255622912323457 0.107653350327026 0.495900555302245 -0.180530210708382 0.272951421918527 0.636920920009132 1.27322092530535 0.0168188889843432 -0.431810304586969 0.255498080786308 0.841410620718377 0.0829699478387288 persistent False False False False True True False 3 insufficient_or_context_specific +BARD1 0.561550372913328 0.123844658575634 0.517432491191746 -0.0024672180758847 0.995596890660316 0.998795540446485 2.7145619433978 0.0058322247062103 -1.13169403856835 0.0443047123181168 1.58286790482944 0.0974026162876568 persistent False False False False True True False 3 insufficient_or_context_specific +ARNTL 0.432682713163177 0.137864946444446 0.537488043399431 0.197287422178557 0.498130398692331 0.789518614144207 0.216787218104777 0.589152199812527 0.0835825171505035 0.0722702272342906 4.0 -0.986439218510799 0.0216412260068623 -0.0292287979602541 0.94472613140216 -1.01566801647105 0.019553149402753 persistent True False False True False True False 3 cross_species_direction_conflict +BAMBI 0.800250595327087 0.143711441601852 0.54262288458519 -0.319276365369092 0.53745859073409 0.812087893451657 0.816946113726138 0.0104097551408974 -0.0993840954030434 0.706634254884492 0.717562018323095 0.0203538436230975 persistent False False False False True True False 3 insufficient_or_context_specific +CTSK -0.530557573344957 0.167240043646042 0.568715760001446 -0.318878960333926 0.4324047082686 0.75112354555773 2.03682108234818 0.0003095936560242 -0.548740735495638 0.0674608462341101 1.48808034685254 0.00401870946594 persistent False False False False True True False 3 insufficient_or_context_specific +FAM111A -0.340731697543793 0.173879620599122 0.573676192501689 -0.0350890284450393 0.889126037838945 0.964276699808303 1.81638430224622 0.0212177934030192 -0.278282260335335 0.561683716886369 1.53810204191089 0.0428656328315468 persistent False False False False True True False 3 insufficient_or_context_specific +POSTN -1.1099022603312 0.179911193001277 0.580473135729219 -1.20384606137673 0.146308131586233 0.532796338690088 0.6458354747886129 0.306320357227428 2.0 1.44842502139622 0.0003351295058949 -0.330600212849919 0.174489125768909 1.1178248085463 0.0033507820838639 persistent False False False False True True False 3 insufficient_or_context_specific +PAMR1 -0.461888417523125 0.189802719514436 0.586844239050912 -0.0480438693054381 0.895133242019192 0.966934394233541 0.474049862759561 1.0 0.597279795543364 0.0219846675192262 0.509073122790828 0.0276053577740526 1.10635291833419 0.0020674151027282 persistent False False False False True True False 3 insufficient_or_context_specific +FBLIM1 0.362434707664688 0.194241366051393 0.592330635883219 0.43943015554368 0.111765735540075 0.490094278471416 0.7812438310118951 0.893122649130539 0.265026547627739 0.128843752025649 4.0 2.98272029986482 7.64342798396254e-05 -1.66993276916626 0.0018504020590579 1.31278753069856 0.0116867189697517 reversed True False False True True False True 3 residual_state_candidate +DSEL 0.53590628996259 0.235030573490638 0.633752316308997 -0.300586474164457 0.487219242090372 0.782147598778917 1.17595575533749 0.0596537817025346 0.504839835202241 0.220585527876635 1.68079559053973 0.0112411873981308 persistent False False False False True True False 3 insufficient_or_context_specific +SHISA5 -0.29380763735655 0.241359541392308 0.640269858798993 -0.194894816892345 0.441915217039231 0.758062305003835 0.565284353000814 0.0499540818811941 0.456654634573538 0.0605094278135818 1.02193898757435 0.003903950913563 persistent False False False False True True False 3 insufficient_or_context_specific +LUZP1 -0.168679760108448 0.243075589751245 0.641918978637729 -0.0154651838265802 0.915347513465685 0.974759629076879 0.715732209209893 0.0080989648790917 -0.16905923955119 0.411368029427231 0.546672969658703 0.0280528767319599 persistent False False False False True True False 3 insufficient_or_context_specific +VOPP1 -0.267532929796114 0.244255285655229 0.642250060235767 0.0102602023500654 0.965507269669568 0.990582362709799 0.943857743662712 0.0517441958657489 -0.129263456071378 0.724867048404529 0.814594287591334 0.0767117584130184 persistent False False False False True True False 3 insufficient_or_context_specific +ZGRF1 -0.312684531294783 0.244432175579601 0.642250060235767 -0.0427966096720336 0.870170714820242 0.958502690861149 2.26302624178027 0.0064437849976779 -0.390567528577079 0.385592878066514 1.87245871320319 0.0207003041200977 persistent False False False False True True False 3 insufficient_or_context_specific +COL6A6 -0.657392500739693 0.276294676336213 0.671472325038926 -0.469335405261816 0.439372162189165 0.756276009860174 0.570226970904261 0.371614067880465 2.0 3.35479688705413 0.0009861086199132 -0.761178058220217 0.106258932652199 2.59361882883391 0.0075508193403489 persistent False False False False True True False 3 insufficient_or_context_specific +AK1 -0.362093218911126 0.277427561128695 0.672049872705933 -0.400634454434495 0.227981975163713 0.600160304082166 2.32616104975723 0.0009247570682051 -1.02843238754478 0.0220239380860891 1.29772866221245 0.0247189928973452 persistent False False False False True True False 3 insufficient_or_context_specific +TNC -0.840009344378596 0.280023801198344 0.673526682356923 -0.81969202623128 0.292552612114746 0.651509781962399 3.0400845387017 7.41344537805846e-05 -1.15383769452189 0.0080477022420879 1.88624684417981 0.0029653352383686 persistent False False False False True True False 3 insufficient_or_context_specific +CSRP1 0.406014777515684 0.291947725169421 0.678578043038158 -0.401396611545402 0.320971547110027 0.672472248121257 0.870374511469362 0.0042776460983021 -0.0315239697173127 0.904538829071086 0.838850541752049 0.0067903396604959 persistent False False False False True True False 3 insufficient_or_context_specific +ITGB1 0.248009811985524 0.310177479398986 0.692944102305225 -0.043254864221285 0.866043642208053 0.958391272020028 0.534382957312811 1.0 0.750915699036292 0.0177421943157426 -0.246195366030359 0.345250052717169 0.504720333005933 0.0761648149636735 persistent False False False False True True False 3 insufficient_or_context_specific +MYADM -0.588325238384825 0.312589237271706 0.693635386110691 -1.4798572510737 0.0105694361352197 0.302245517751671 1.23370289336947 0.0023758671660028 0.126153895636752 0.670049273231752 1.35985678900623 0.002729355358263 persistent False False False False True True False 3 insufficient_or_context_specific +LATS1 -0.200457943476778 0.32025826841763 0.698830106468333 -0.143107744442853 0.479045242794473 0.779556053240451 0.879030727349529 0.0169953780466074 0.272482899500891 0.296556406587841 1.15151362685042 0.0054150130798585 persistent False False False False True True False 3 insufficient_or_context_specific +ALCAM -0.325456364876759 0.321326971431235 0.699468092160676 -0.0236921230010709 0.943311280293171 0.984366565940656 1.37524621856937 0.0006397302283421 -0.119805923419583 0.653058027809335 1.25544029514979 0.0025612869102069 persistent False False False False True True False 3 insufficient_or_context_specific +UGDH -0.295793172226798 0.326705487735317 0.703567204687985 -0.30612473892256 0.311549686983319 0.664110962077504 1.11649362055066 0.0037749271380241 -0.312431769946584 0.269502033942772 0.804061850604079 0.0204518785808285 persistent False False False False True True False 3 insufficient_or_context_specific +NR1D2 -0.257193787218978 0.336431432299954 0.709698913531051 -0.0593791587580947 0.826573754611473 0.94202997638039 0.636655808109551 0.0577091094285948 0.158219977581708 0.580937569533995 0.794875785691259 0.0217463859361835 persistent False False False False True True False 3 insufficient_or_context_specific +OTUD6B -0.245868502881542 0.367429479262829 0.729567043961616 -0.288058600219983 0.284161169249773 0.645043543745796 1.11976110890821 0.0665458328957903 0.824008128598169 0.0574511026544237 1.94376923750638 0.0053819116927464 persistent False False False False True True False 3 insufficient_or_context_specific +MATN2 -0.390600372346951 0.374651971863979 0.735203486361493 -0.501010426434442 0.257279002815089 0.621906676979798 0.955455007663278 1.0 1.10074432026246 0.0021799056646577 0.121684027767507 0.615753846512249 1.22242834802996 0.0025612869102069 persistent False False False False True True False 3 insufficient_or_context_specific +ASXL1 -0.127127846291117 0.378610377915615 0.737794088230539 -0.11263928614696 0.43480862268688 0.75243712029294 0.556462377768676 0.0596537817025346 0.052196959296375 0.846977529705576 0.608659337065051 0.0360694971590092 persistent False False False False True True False 3 insufficient_or_context_specific +HTRA1 -0.219395113783205 0.379297475274054 0.738922618800748 -0.123168224867017 0.632657324213693 0.860661774133252 0.5269090233218859 1.19025114443027 2.0 0.912791339183199 0.0165428644329816 0.896210822312392 0.0080112576849898 1.80900216149559 0.0011629508383151 persistent False False False False True True False 3 insufficient_or_context_specific +TBC1D1 -0.188363748121779 0.395568692413612 0.747791272068561 -0.167939307810596 0.447650558956252 0.761936901734662 0.356229834496295 1.0 0.982619135588578 0.0012499322672718 -0.284455354368012 0.15729543200175 0.698163781220566 0.0101653152510322 persistent False False False False True True False 3 insufficient_or_context_specific +P3H2 -0.353637789008928 0.416850631076947 0.761832951862629 -0.29508743502153 0.497338405106135 0.789146979692815 0.568997335008754 1.0 0.837153555035499 0.0086229685195665 0.18857091523162 0.410964931815711 1.02572447026712 0.0041412353303569 persistent False False False False True True False 3 insufficient_or_context_specific +SNRPD1 -0.309890585941795 0.425003000553645 0.765579345650124 -0.0962253475191742 0.812151941816499 0.934063202799411 0.548829484567299 0.0673006948216067 -0.0817245626820099 0.756174988536781 0.467104921885289 0.0973214087195158 persistent False False False False True True False 3 insufficient_or_context_specific +CSE1L -0.128044062369176 0.437147806867917 0.773488611515244 0.073076466698068 0.664111495478657 0.874384483010807 0.739162820574605 1.0 0.512271416156583 0.0566473964313001 0.0493815154636782 0.836543207084056 0.561652931620261 0.0338094136099771 persistent False False False False True True False 3 insufficient_or_context_specific +RIT1 -0.189627134764033 0.440399330968604 0.775222968743735 -0.0633875498132934 0.797299544527939 0.92925379048471 0.409760041181867 1.0 0.578256468484755 0.0353714299371428 -0.0853350051571324 0.718440490948663 0.492921463327622 0.0570571945417509 persistent False False False False True True False 3 insufficient_or_context_specific +COTL1 -0.287845498583254 0.461512886870092 0.786536199487743 -0.726252739815517 0.0609407761872097 0.429268745755419 0.331735472576996 1.0 1.1125043279115 0.0054327199072906 0.0050375122875968 0.988665629929683 1.1175418401991 0.0068388228821503 persistent False False False False True True False 3 insufficient_or_context_specific +ACAT2 -0.282618365472288 0.461730570602864 0.786536199487743 -0.651031028292349 0.0867117609202105 0.467809285536833 0.838911241040989 0.0426771445279066 0.364716719465013 0.238306783981868 1.203627960506 0.0085629559689659 persistent False False False False True True False 3 insufficient_or_context_specific +NID1 0.19250517297967 0.465914194322913 0.788952759414185 -0.203962271045255 0.43790403554527 0.754716096520888 0.9030832460057572 1.21812539015536 2.0 1.15904687098473 0.0018195703596251 -0.147599620281913 0.577372148145228 1.01144725070282 0.0053819116927464 persistent False False False False True True False 3 insufficient_or_context_specific +FBLN7 -0.272090857437049 0.479712508711691 0.796259928777002 -0.301653310291317 0.433844766795654 0.751660242498796 0.601672321801575 0.0962020820874513 0.19086228723662 0.508982574672744 0.792534609038195 0.0298248636211815 persistent False False False False True True False 3 insufficient_or_context_specific +FRMD6 -0.242438705216161 0.487637495723332 0.801870463516161 0.239609090188346 0.473125912844029 0.775902980398766 0.90393327555233 0.0301670750841989 0.138035319329754 0.662923252243797 1.04196859488208 0.0160659722651676 persistent False False False False True True False 3 insufficient_or_context_specific +REV1 -0.100314490775866 0.490677691603139 0.803961853503271 0.0099312824998795 0.944891623129875 0.985105732892783 0.4598405542077029 0.8844578345673779 2.0 0.620212415687933 0.0607211806197977 -0.0926471439703685 0.74272938512306 0.527565271717564 0.0892078129246425 persistent False False False False True True False 3 insufficient_or_context_specific +ENTPD5 -0.16309911924122 0.49298963830829 0.805600464519258 -0.238726740977462 0.306266933117544 0.661696690217148 0.48804353731955 1.0 0.825468485027398 0.0812488705646871 0.176272899053191 0.679611196462262 1.00174138408059 0.034612010305315 persistent False False False False True True False 3 insufficient_or_context_specific +LOXL2 -0.258585850022292 0.499296562215136 0.809019813362094 -0.157485779527398 0.685706997214477 0.883592781626934 1.70018627541132 0.0002594175241996 -0.790413174187826 0.0121573936932156 0.909773101223489 0.011334705867474 persistent False False False False True True False 3 insufficient_or_context_specific +PTGR1 -0.253763208603578 0.504067076830579 0.810255529903501 -0.313152247319784 0.411479943353835 0.735291083225579 2.04523501778522 0.0012920401448548 -0.906241539240323 0.019952931635508 1.13899347854489 0.0351523500715243 persistent False False False False True True False 3 insufficient_or_context_specific +UBAP2L 0.0998643374057168 0.511946438362424 0.815116748951848 0.146209648887046 0.337338078009817 0.685057785656405 0.28989235520067 0.315858617813484 0.0710927877233805 0.0715397902883008 4.0 0.416867209069047 0.0952101855731232 0.0347729410961997 0.888779737428077 0.451640150165247 0.061019286714691 partial_or_other True False False True True False True 3 residual_state_candidate +CMYA5 -0.203770327591641 0.538021941624283 0.826341236989805 -0.235434844763914 0.479924523473974 0.780162456875056 2.82695764594179 0.0016591196775018 -1.10064573857439 0.0248261145372004 1.7263119073674 0.0332378569949644 persistent False False False False True True False 3 insufficient_or_context_specific +FSTL3 -0.160821210427377 0.564620734532814 0.841986682937493 0.0638481609138542 0.82510489617521 0.941168700714981 0.609624500139438 0.314394362669461 2.0 3.19185325579914 0.0015484713424545 -1.51701975171016 0.010890979420327 1.67483350408899 0.0612430771660088 persistent False False False False True True False 3 insufficient_or_context_specific +CKB 0.278399725176861 0.566408908966595 0.842808157051877 -0.154019982343611 0.740318518138425 0.908274440555399 1.0229892040861 1.0 2.35735842116458 0.0012991141537219 -0.678223995326028 0.113490612296533 1.67913442583856 0.0112304993030495 persistent False False False False True True False 3 insufficient_or_context_specific +FLRT2 0.33118205835635 0.568445865852826 0.843747506689109 0.657305642040175 0.247216280869365 0.612557966068705 0.598768966856994 0.9903518180803871 0.365793225850115 0.0997004790048096 4.0 -1.95978648227972 0.0155945474226114 0.333155449183398 0.64878559638908 -1.62663103309632 0.0298131918658172 persistent True False False True False True False 3 cross_species_direction_conflict +GSTM3 0.352750417580459 0.583600591789061 0.851902140560306 -0.0384116007914007 0.952780498669318 0.987149466215884 4.20261042834322 0.0001979531072831 -0.326513059877788 0.550040558206469 3.87609736846544 0.0013398525608679 persistent False False False False True True False 3 insufficient_or_context_specific +FBLN1 0.231732594364287 0.597336250673005 0.85910313780215 0.446466963882726 0.312916402884027 0.665412161460132 1.11938265192584 1.18623009062351 0.3750167365650121 0.113851132990582 4.0 0.394546819903212 0.579312487844748 1.00660202044215 0.0624461886446697 1.40114884034536 0.0298248636211815 partial_or_other True False False True True False True 3 residual_state_candidate +TIMM50 -0.169992160854914 0.60912183510553 0.864960526893789 -0.269871968433914 0.413053849818434 0.735665071926961 0.364037794105437 1.0 0.568889199481668 0.0659183754578961 0.120268979617789 0.65257124852416 0.689158179099456 0.0279136606474788 persistent False False False False True True False 3 insufficient_or_context_specific +MYL9 0.184231030116281 0.61336230548723 0.865517763981887 -0.314622815374187 0.400872909770847 0.730608696937787 0.740175579055477 1.0 0.980612673375303 0.0275754772117547 -0.122383113421029 0.751355682708213 0.858229559954274 0.0418804103457958 persistent False False False False True True False 3 insufficient_or_context_specific +NOL11 -0.110580288666306 0.6205196189181 0.867761634779139 -0.250044731095161 0.259583267896593 0.622885940784012 0.313395734181654 1.0 0.791848861872499 0.0540770702690188 0.0311253597587565 0.931942990277106 0.822974221631255 0.0396757426500509 persistent False False False False True True False 3 insufficient_or_context_specific +GPRC5B 0.224519193147102 0.621181009410375 0.867761634779139 -0.589876976984238 0.140826144850844 0.526401063874107 1.43331816511731 0.0205616795162199 -0.282981521852699 0.507256198459734 1.15033664326461 0.0492199242141408 persistent False False False False True True False 3 insufficient_or_context_specific +SRPX -0.190143502044195 0.630997670447262 0.872570190515022 0.0026567154383923 0.994759876928448 0.998795540446485 0.4791369999120271 1.0 2.44331799956806 0.0031948261250898 -0.514119755350386 0.26192288460731 1.92919824421767 0.014632661942696 persistent False False False False True True False 3 insufficient_or_context_specific +MCC 0.10249018656251 0.631540902256835 0.872832276143984 -0.0786519336067949 0.712895088247986 0.895497343705388 1.11759934091959 0.442596118323727 0.18523886793913 0.126098256781616 4.0 -1.1862986851477 0.0009793488252669 0.378276588855609 0.124961182115022 -0.80802209629209 0.0095170977344524 persistent False False False True False True False 3 insufficient_or_context_specific +ADAMTS5 -0.276248888759554 0.638473804880841 0.875569091041943 -0.220235534148164 0.708722010885829 0.893775321420519 1.90908186100895 0.0001594366607477 -0.738262059086059 0.018536714289662 1.17081980192289 0.0045073016630279 persistent False False False False True True False 3 insufficient_or_context_specific +CAND1 0.113731499112333 0.661104637125111 0.884881181385259 -0.123498176882891 0.64193678443672 0.864816711762523 0.570495958614549 0.092307296143151 0.128504144193979 0.661208120838912 0.699000102808528 0.037420038932345 persistent False False False False True True False 3 insufficient_or_context_specific +CRAT -0.16939229420664 0.669463113950256 0.888521880212043 -0.122995815490865 0.759893421040467 0.915425158472589 0.023111862045514 1.0 0.746115500883645 0.0577091094285948 0.109335042254631 0.738778587855958 0.855450543138275 0.0294267198956205 persistent False False False False True True False 3 insufficient_or_context_specific +MEF2C -0.127195719395959 0.684332014390908 0.895313185618242 0.129640304705432 0.67330977815268 0.877630202189629 0.5930263427211441 1.0 0.920599420861681 0.0091229805120675 -0.340904451667345 0.18512077146683 0.579694969194336 0.0629660052504326 persistent False False False False True True False 3 insufficient_or_context_specific +CXCL14 -0.322938212390092 0.689219066562143 0.8974808713324 -0.0262175775986441 0.973994624026691 0.992450915625761 0.709001722738171 0.0663323696670329 0.153699251559585 0.647221005781932 0.862700974297756 0.0277837071492711 persistent False False False False True True False 3 insufficient_or_context_specific +DDX5 -0.0644563000878032 0.69246831798128 0.898427828802679 -0.0528129937370672 0.744553715506172 0.909500945159707 0.582838983727604 0.430970445779614 2.0 0.8354116416627 0.0177852215254438 0.925868758845231 0.0062043014223429 1.76128040050793 0.0009293818384144 persistent False False False False True True False 3 insufficient_or_context_specific +DEGS1 -0.129528272198344 0.694363855312452 0.898528445200253 -0.197961676998508 0.546691382587649 0.815603096463177 1.35322493099694 1.0 0.575925296350723 0.0906490900672602 0.517484059844012 0.0799696695885266 1.09340935619474 0.0065314512951213 persistent False False False False True True False 3 insufficient_or_context_specific +EDNRB 0.113233743875899 0.702567466784022 0.901539236705661 -0.17234805582712 0.552942948167682 0.819071644755648 1.00803329232824 1.0 0.986683539851987 0.0060199649903166 0.343032365420655 0.206246647674888 1.32971590527264 0.0025612869102069 persistent False False False False True True False 3 insufficient_or_context_specific +FAM180A -0.131005575721285 0.708337126651618 0.903772295206127 -0.310379989908748 0.368926260311649 0.709345639075664 1.17339642218388 0.0170451803274202 1.22753063115876 0.0051240014823383 2.40092705334264 0.0009293818384144 persistent False False False False True True False 3 insufficient_or_context_specific +PLAT -0.168883153964357 0.709280179079222 0.904527132590703 0.0312170858097639 0.945566484196538 0.985432868134933 0.90506865672171 1.0 3.64961211085453 2.19248200951623e-05 -1.20721869486298 0.0040155626029722 2.44239341599156 0.0009293818384144 persistent False False False False True True False 3 insufficient_or_context_specific +SDK2 -0.15343755154755 0.712259256227712 0.905155660478115 -0.303425528478081 0.461688760119408 0.769126302007068 0.311003594121159 1.0 0.891053864676447 0.0299525668371215 0.121163985966859 0.699986375642058 1.01221785064331 0.0168966976650542 persistent False False False False True True False 3 insufficient_or_context_specific +ENG 0.108680891503937 0.726227391359717 0.911848573130595 0.181175095986845 0.56658912306719 0.824128464432343 0.651453410162819 0.694447522921341 0.139129820348703 0.0825343572901409 4.0 0.262701591198798 0.415605940026351 0.862305581275221 0.0091920347644963 1.12500717247402 0.0041412353303569 partial_or_other True False False True True False True 3 residual_state_candidate +TUBA1C -0.0730005181761319 0.731727840821189 0.914014458927124 -0.215100030897874 0.298731217565795 0.656810536247326 0.825336347336945 0.0641495577533093 0.160091397538731 0.678958009015869 0.985427744875676 0.0285207557893931 persistent False False False False True True False 3 insufficient_or_context_specific +PIGC 0.113076345278377 0.737019862644076 0.915714901073583 -0.0421456069157535 0.898779485566374 0.967837995533705 0.608251609407851 0.0682430011675514 0.120714570854974 0.661393228396416 0.728966180262825 0.0298248636211815 persistent False False False False True True False 3 insufficient_or_context_specific +MINPP1 -0.0808451880898726 0.748408737027787 0.919189349632913 -0.062898554929709 0.802702203109227 0.930901786075046 0.595741178021097 0.5334267775371629 2.0 0.574851969769707 0.0310007319091614 0.330352633730679 0.122871034512377 0.905204603500387 0.0043816927489726 persistent False False False False True True False 3 insufficient_or_context_specific +ITM2C -0.111483717315842 0.753431797645896 0.920343414820209 -0.26171740051823 0.451587607599652 0.764202910889105 0.805738854231904 1.0 0.773368438291272 0.0098419429663311 0.44679920007477 0.066839602848813 1.22016763836604 0.0020737966920285 persistent False False False False True True False 3 insufficient_or_context_specific +SERPINE2 -0.136041463347646 0.762412137630949 0.924433579099978 0.123325317135786 0.784187385777494 0.925388445181489 0.597308222062723 0.38471146551242 2.0 1.77351119458727 0.0126643540989096 -0.522425278835484 0.296999983746767 1.25108591575178 0.054611121886113 persistent False False False False True True False 3 insufficient_or_context_specific +NTN4 0.169115376326881 0.77350120651728 0.929187136011997 -0.384742346777095 0.50446240191564 0.792758405693685 0.868058777419627 0.0302390506782496 0.227719373794629 0.433884592767693 1.09577815121426 0.0107207599930765 persistent False False False False True True False 3 insufficient_or_context_specific +TMEM64 -0.0976664937009695 0.779755861224489 0.931929180757092 -0.3194168134064 0.350301066211682 0.695333456864625 0.999985605220935 0.003091207359983 -0.388325376719038 0.10181145827063 0.611660228501898 0.0334859932338936 persistent False False False False True True False 3 insufficient_or_context_specific +ITIH5 -0.124157106138418 0.789285752423847 0.935813320117497 -0.234570518700825 0.613822525010804 0.850602207515956 1.23816156541106 0.0244356740939506 -0.2296226006177 0.571616151147389 1.00853896479336 0.0518777867306521 persistent False False False False True True False 3 insufficient_or_context_specific +IGFBP3 -0.171630446285894 0.794457381313874 0.935936945981962 0.166058539861236 0.803898829937521 0.931585378484075 0.6487829017212111 1.0 0.795270815388702 0.0404151110500116 0.992752744718058 0.0110267120469729 1.78802356010676 0.0017468801289819 persistent False False False False True True False 3 insufficient_or_context_specific +ACTG1 -0.074168462338027 0.795414010332224 0.93672710324948 0.206932159480621 0.455923281599564 0.767060408474954 0.453399656624044 1.0 1.20158949166599 0.0167012860705809 -0.354184631654 0.366803505956 0.847404860011989 0.062290902625138 persistent False False False False True True False 3 insufficient_or_context_specific +LCLAT1 -0.0682066340707404 0.797937051805539 0.937262024585861 0.323918013321178 0.210433700581931 0.582800422305635 0.140224693371314 0.360908359464429 2.0 1.1059986709992 0.0061539711097974 -0.518169023402739 0.0880706424303801 0.58782964759646 0.0865458485086114 persistent False False False False True True False 3 insufficient_or_context_specific +TBX20 0.108607196976245 0.800263823700854 0.938694084061061 -0.0320060926308862 0.939827076807319 0.983658266508924 0.947289373395685 0.0100368683022182 -0.174649158599893 0.553551421163826 0.772640214795792 0.0257986126069065 persistent False False False False True True False 3 insufficient_or_context_specific +SOCS5 -0.0775555493968904 0.807395196247683 0.941307252869151 0.124447112227134 0.693941558753942 0.887324085905792 0.320956973367183 0.0935574926282127 2.0 0.788588823209029 0.0589580930830448 -0.100530967392691 0.782580983089329 0.688057855816338 0.0803502835541545 persistent False False False False True True False 3 insufficient_or_context_specific +NXPE3 -0.0745378551759187 0.808157830394105 0.941508256818038 0.198092516085656 0.525264613670257 0.804676662787375 1.31169146881091 0.0416085275593095 0.185547658324511 0.676808901691855 1.49723912713542 0.0215252001116873 persistent False False False False True True False 3 insufficient_or_context_specific +CERCAM -0.0944434589137267 0.808644728633777 0.941508256818038 0.374426392504682 0.344144582054575 0.69073818751447 1.63422750396798 0.0021799056646577 -0.579681952195684 0.0799696695885266 1.0545455517723 0.0239227480431678 persistent False False False False True True False 3 insufficient_or_context_specific +OAZ2 -0.0638419646270244 0.828568287730576 0.947127722307772 0.0582548202184483 0.846967917537962 0.952541014278606 0.870049105523477 1.0 0.751743233221976 0.0266361505160167 0.476841241516198 0.081599874011745 1.22858447473817 0.0035440769053387 persistent False False False False True True False 3 insufficient_or_context_specific +CMC2 0.0522626713878883 0.834677877547457 0.948225126875272 -0.0070258858115952 0.977994865020282 0.993500350721674 0.341464803785874 1.0 0.91608069858454 0.0229064146333817 0.0931119188665343 0.767157356083017 1.00919261745107 0.01519228421204 persistent False False False False True True False 3 insufficient_or_context_specific +RBP1 -0.0846335072696327 0.835417519772553 0.948225126875272 0.0498321762535257 0.904203476022456 0.969786702544198 0.372450421880347 1.0 0.673991732365929 0.0389395870342123 -0.0687804843151593 0.821022441600952 0.60521124805077 0.0507782589652587 persistent False False False False True True False 3 insufficient_or_context_specific +EMP1 0.128672666610314 0.839037209023814 0.949063086873091 -0.0406328379612336 0.952474376320178 0.987065612994547 0.4894272498974361 1.0 2.75055890183748 1.4021996351485e-05 0.310351508770439 0.15258910497236 3.06091041060792 1.03859799815227e-05 persistent False False False False True True False 3 insufficient_or_context_specific +ADAM10 -0.0348879923171439 0.847214399650363 0.950376610463724 0.128864549427261 0.483618616249421 0.780666906162311 0.21867137919592 0.702318825757612 2.0 0.712069124746289 0.0366405655749477 -0.157245639059149 0.570672402438986 0.55482348568714 0.0804216787755617 persistent False False False False True True False 3 insufficient_or_context_specific +TUBA1A 0.0984264081991588 0.853552159972655 0.951655796828666 -0.836346003559182 0.0858596813925714 0.467503293000484 0.969189008383742 0.0056665927006969 0.0801402182818068 0.773698435551437 1.04932922666555 0.0053462866895584 persistent False False False False True True False 3 insufficient_or_context_specific +SFRP1 -0.104308368846087 0.857528122221204 0.953330727009737 0.127412279528317 0.820473409555849 0.937912327640825 2.28326114051067 0.0238003515500527 -0.215089293208554 0.746002714571707 2.06817184730212 0.0351536000012139 persistent False False False False True True False 3 insufficient_or_context_specific +CCDC3 -0.0537496785857432 0.862724091028064 0.954916504314124 -0.101342742011965 0.743213613990958 0.909273715761109 0.9184997669231171 1.0 1.31053139053249 0.0003095936560242 -0.407947182655299 0.0738306569115781 0.902584207877193 0.0045163244044198 persistent False False False False True True False 3 insufficient_or_context_specific +SNAI1 -0.112646149092102 0.866973032953595 0.956719163640979 -0.277997271406853 0.669978551031573 0.876409243055816 0.394661085035355 1.0 0.652331973646297 0.0403570561654693 0.0953426820238736 0.731058459540667 0.747674655670171 0.0217271401484915 persistent False False False False True True False 3 insufficient_or_context_specific +DPT -0.0885621103664635 0.876156146400285 0.958992930612751 0.273978664864891 0.636229077918173 0.862000078223965 0.8778717726019091 1.0 1.99249599205744 0.0001249977938437 0.326656160123471 0.225342660286079 2.31915215218092 0.0002114901806361 persistent False False False False True True False 3 insufficient_or_context_specific +VIRMA -0.0296201717602994 0.880040396893797 0.960383728795751 0.0867064019208993 0.665994086046244 0.87511808324756 0.57888090337508 0.0561649376038071 -0.0369512661423246 0.894948796670644 0.541929637232756 0.060593595564402 persistent False False False False True True False 3 insufficient_or_context_specific +DYNLL1 -0.0395924315823426 0.880142995988426 0.960383728795751 -0.077376818147862 0.767480962157707 0.91954879692023 0.511432539619935 0.3893536599201929 2.0 0.875605189049366 0.0464209051683119 0.0164568052808807 0.967568471469058 0.892061994330247 0.0371806110676655 persistent False False False False True True False 3 insufficient_or_context_specific +TPM4 -0.0459561006261603 0.907261639081881 0.970089952147654 -0.283531402574727 0.489168922570406 0.78394740201857 0.361604846339284 0.414520631798673 2.0 1.49088100713794 0.0025246825383285 -0.497588121374285 0.135407394708641 0.993292885763659 0.0214867994678872 persistent False False False False True True False 3 insufficient_or_context_specific +LAMB1 0.0278819076602811 0.910927114636001 0.971471563265343 -0.151048652188828 0.54399623250583 0.814999982025397 0.8408636696112328 0.658295476253309 2.0 0.935224637804955 0.0050813992631754 -0.17798615216213 0.483681332167866 0.757238485642825 0.0162522145230198 persistent False False False False True True False 3 insufficient_or_context_specific +CAP1 -0.0220644145140458 0.91757852465778 0.973181851556645 -0.0326637218434742 0.878442508823702 0.961432567887278 0.217796097765386 1.0 0.634130883823021 0.0168188889843432 0.206542455658839 0.326980857406926 0.84067333948186 0.0053819116927464 persistent False False False False True True False 3 insufficient_or_context_specific +EPHB3 -0.0432338364401035 0.91897983336982 0.973276063869853 -0.0446562459569227 0.916452890567194 0.975492450711608 1.07997395365404 1.0 0.787294943874738 0.038993930039121 -0.17107572933905 0.56623432023254 0.616219214535688 0.0838789840415141 persistent False False False False True True False 3 insufficient_or_context_specific +FDFT1 -0.0186668381586263 0.936340602279157 0.980839773674307 0.0162081978034999 0.943624855887278 0.984368266817299 0.393236225115777 1.0 0.842055662229588 0.0172937043771707 0.0082017418936459 0.980613792462185 0.850257404123234 0.0174071293166494 persistent False False False False True True False 3 insufficient_or_context_specific +FSTL1 -0.015861480624189 0.938697564649211 0.981555797520686 -0.229328406996344 0.275875348440246 0.6396696093258 0.462682508432433 1.0 1.78635171044007 0.0004080989484012 -0.806938890764295 0.0203068315157346 0.979412819675772 0.0142422430114352 persistent False False False False True True False 3 insufficient_or_context_specific +LTBP1 -0.0187384351118229 0.945947718270173 0.983875087133926 -0.294887852695515 0.253760393288359 0.618991529980024 1.51352430434713 1.0 0.842791978660669 0.012292899394134 0.595719238401787 0.0312163810364773 1.43851121706246 0.0017468801289819 persistent False False False False True True False 3 insufficient_or_context_specific +WDR66 -0.0229774034191205 0.951775137077024 0.9860827708185 -0.470011834300592 0.189540015525405 0.569886897607216 0.519065716395228 1.0 0.826953345760798 0.0118902233379293 -0.305217250077298 0.239397571433951 0.5217360956835 0.0726775605106815 persistent False False False False True True False 3 insufficient_or_context_specific +STEAP4 0.0205630000646489 0.95204100010156 0.9860827708185 -0.38955164586406 0.257527532082756 0.621906676979798 0.767209692743395 0.0432589061898257 0.042431210426347 0.910476463165681 0.809640903169742 0.031104344860037 persistent False False False False True True False 3 insufficient_or_context_specific +CBX3 -0.0168329128140733 0.954150055685047 0.98638169861184 0.115291423192411 0.691079563081997 0.885824849193387 0.0242745814386372 1.0 1.13061803139144 0.0204610267805179 0.56828476800133 0.0837810961755447 1.69890279939277 0.0035440769053387 persistent False False False False True True False 3 insufficient_or_context_specific +MYO10 -0.0108738123685264 0.971313064267124 0.993148421080372 -0.289383610698187 0.328814851923632 0.677655125241013 1.15562684002753 1.0 0.850540619950038 0.0099832366442231 -0.170860543239002 0.51782994180536 0.679680076711036 0.0276126768019347 persistent False False False False True True False 3 insufficient_or_context_specific +HES1 0.0126320650279216 0.975760970863589 0.995178161744376 -0.0821138759688391 0.847803542277565 0.952893503643581 0.170973753762322 1.0 0.503704964548323 0.0922155151146392 0.488370723684858 0.0653276421182545 0.992075688233181 0.0056996297641849 persistent False False False False True True False 3 insufficient_or_context_specific +COLGALT1 0.005499083831568 0.979821329590129 0.996040674920114 -0.0355989106165947 0.870280117685912 0.958502690861149 0.408990896904867 1.0 0.613328191247674 0.0190656622159569 0.104164529108414 0.634582061607417 0.717492720356088 0.0102768612373226 persistent False False False False True True False 3 insufficient_or_context_specific +ADGRL3 -1.88995388741006 4.4955268281386e-05 0.10272882660725 -1.0153459735402 0.0393161131349873 0.379484931484566 False True False False False False False 2 insufficient_or_context_specific +RASGRP2 -1.01836137166062 8.54799830492206e-05 0.108955765289858 -0.711504917171832 0.0130707079546735 0.313114831651016 0.464597364806876 1.0 -0.418413641532186 0.314672093652591 -0.305573434638158 0.400678101529428 -0.723987076170344 0.0677144109380963 partial_or_other False True False False False False False 2 insufficient_or_context_specific +GABRE 1.72070119799967 0.0001113543454386 0.108955765289858 1.57160492517506 0.0004840807545753 0.159716393962721 0.036182412090943 1.0 -0.164909674280156 0.858155116995461 0.047994540412572 0.946815497290544 -0.116915133867584 0.882553382780557 partial_or_other True True False False False False False 2 cross_species_direction_conflict +ZC3H4 -0.730455963729018 0.0001135662222813 0.108955765289858 -0.48608746244355 0.0188036404279162 0.330115789697373 0.22421468971657 0.307435809961115 -0.203632812577329 0.27527329613531 0.0205818771392403 0.929848883257229 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AL122019.1 -2.06734351313221 0.0001359240950466 0.108955765289858 -1.489201264196 0.0145093051976593 0.317541556275699 False True False False False False False 2 insufficient_or_context_specific +PDGFD 2.83405706211225 0.0001695452140602 0.108955765289858 2.5358542030547 0.0008903072132862 0.177355916186346 0.3781881678491621 0.2800749091988839 2.0 -0.32719449489056 0.437516317519058 -0.279915197505537 0.428631126686757 -0.607109692396097 0.113718054790355 partial_or_other True True False False False False False 2 cross_species_direction_conflict +AC007319.1 1.54618863537757 0.0002253560299023 0.108955765289858 1.1693049465894 0.0072648331352623 0.287273813640823 0.142994153682552 0.386312563010636 2.0 True True False False False False False 2 insufficient_or_context_specific +KCNQ3 3.50489656788389 0.0002468434213648 0.113311862729156 3.58450272472146 0.0001819095419806 0.112976526131278 0.5013391855323089 0.156439227683022 2.0 True True False False False False False 2 insufficient_or_context_specific +KCNMB2-AS1 1.99323071615749 0.0002703188497084 0.118917767300903 1.83521454922476 0.0008083673868022 0.177355916186346 0.0678494257098797 1.0 True True False False False False False 2 insufficient_or_context_specific +IL32 1.35177194636867 0.0003588733688137 0.128042361093427 1.14700682171486 0.0035410046043819 0.243710520549117 True True False False False False False 2 insufficient_or_context_specific +MGP 2.74337683775218 0.0003620559917536 0.128042361093427 2.50367175847139 0.0013275486232644 0.19529322644992 0.178672117077082 1.10455904294767 0.156637803213713 3.0 -1.28454513882829 0.0369779144586463 0.954248093643499 0.0761092121522769 -0.330297045184788 0.547025172819312 reversed True True False False False False False 2 cross_species_direction_conflict +AC245297.3 0.88029254489125 0.0003648720644635 0.128042361093427 0.816681434094008 0.0011869901787224 0.187272944881803 0.360511363388319 0.320876270688864 2.0 True True False False False False False 2 insufficient_or_context_specific +GSTT2B 1.29153592014248 0.0003773337571416 0.128042361093427 1.0717749391341 0.0044743883647894 0.261521011602645 0.102682165256858 1.0 True True False False False False False 2 insufficient_or_context_specific +RORB 2.43343651413781 0.0004123356958871 0.128042361093427 2.3852959801438 0.0005576596292851 0.169660663319394 0.141368387043778 1.0 True True False False False False False 2 insufficient_or_context_specific +CDH6 2.49983793099698 0.0004254591943329 0.128342804964786 2.45782404310463 0.0005803687866827 0.170209268049906 1.3263510505796 0.11174527254803 2.0 True True False False False False False 2 insufficient_or_context_specific +CDHR5 -2.04398369906446 0.0004880490342305 0.138619773467801 -1.9477308796016 0.0011758877194349 0.187272944881803 -0.71049504199329 0.0742128078934692 1.18265188855964 0.0057854606393944 0.472156846566348 0.184398210673637 reversed False True False False False False False 2 insufficient_or_context_specific +LEF1 5.75209205165562 0.000534185121296 0.138619773467801 6.18016002857574 0.0007145691772366 0.173313203041643 0.0781464905840511 1.0 True True False False False False False 2 insufficient_or_context_specific +MIS18BP1 1.01924152075894 0.0005394815441706 0.138619773467801 0.828207472696281 0.0069504253774082 0.282692791660547 0.29220638535332 0.0788181836345994 0.120063172020538 3.0 True True False False False False False 2 insufficient_or_context_specific +RPS27L 0.876498443009297 0.0005754114686179 0.138619773467801 0.767189277509123 0.0032712759682984 0.237767279776889 0.0642308780914313 1.0 True True False False False False False 2 insufficient_or_context_specific +GPRIN3 2.06837386854216 0.0005908211598836 0.138619773467801 1.70287797090715 0.0034906714105216 0.243710520549117 0.416791540888474 1.0 -0.726296627031781 0.126894114413948 0.773070967756345 0.0644671183128842 0.0467743407245632 0.925049234357272 partial_or_other True True False False False False False 2 cross_species_direction_conflict +PLIN3 -1.26032204434744 0.0006675796170987 0.142837651901635 -0.864943805629954 0.0364501730205782 0.377876708853838 -0.152528457387975 0.561447014082597 -0.0187419699687871 0.940025122441445 -0.171270427356762 0.449211811249219 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FAM163A -2.1299049244153 0.0006802926553095 0.142837651901635 -2.05483938310997 0.0012277112733055 0.187272944881803 False True False False False False False 2 insufficient_or_context_specific +SLC17A8 -2.47128510953386 0.0006890148425287 0.142837651901635 -1.82323747488602 0.0188539326754609 0.330115789697373 -1.21067155968873 0.0251042920058719 0.617318305107208 0.171409125642113 -0.593353254581527 0.193737031686591 reversed False True False False False False False 2 insufficient_or_context_specific +AC005165.1 2.53407760098392 0.0006899716089205 0.142837651901635 1.66810686174057 0.024655148875895 0.349408136686844 0.06021335009958 1.0 True True False False False False False 2 insufficient_or_context_specific +AP002989.1 3.13127917276803 0.0007400889670569 0.146046546524121 2.45068015824087 0.0079395285041883 0.287862310479138 0.283936140222005 0.233304899829221 2.0 True True False False False False False 2 insufficient_or_context_specific +POT1-AS1 2.93328535813954 0.000786185518122 0.146549458248405 3.07650717380229 0.0004582326630676 0.159716393962721 0.46500588737082 0.386587684817432 2.0 True True False False False False False 2 insufficient_or_context_specific +IGSF9 -2.20293062713626 0.0008050642714915 0.146549458248405 -1.75584998575936 0.0122406353475323 0.309429533546452 False True False False False False False 2 insufficient_or_context_specific +FAM78B 2.05413840269976 0.0008210514075819 0.14692645358051 2.00927032606241 0.0011117196762114 0.187272944881803 0.470651042804883 0.333711224419924 0.257057016870831 3.0 -0.584685171842877 0.485192456578649 -0.589208702940006 0.414047562523943 -1.17389387478288 0.135896271864819 partial_or_other True True False False False False False 2 cross_species_direction_conflict +GPC3 2.19128316677481 0.0008598489609659 0.14718914218163 2.33378882568691 0.0003734362349285 0.148975599106358 0.44732164670178 0.338766720208127 0.234943830372065 3.0 -1.11655595090883 0.0777123256625024 1.65262323440966 0.0093613596907365 0.536067283500826 0.32040271875423 reversed True True False False False False False 2 cross_species_direction_conflict +TMEM132C 2.42411553266937 0.0008643423768953 0.14718914218163 2.49022192290039 0.0006340906066346 0.170662739118283 0.185061694500563 1.0 True True False False False False False 2 insufficient_or_context_specific +HOXB-AS3 1.23088447483946 0.0008857142140363 0.148000497085406 1.0275434208713 0.0058413263994439 0.266412407248749 0.0342233997325161 1.0 True True False False False False False 2 insufficient_or_context_specific +PRR5 -0.88943357069916 0.0009251783299523 0.148000497085406 -0.719794869023351 0.0119162421763673 0.306601496403255 0.338694931969967 0.6014581154448261 2.0 -0.171197989456851 0.730417369909899 0.479522295231695 0.195726768877184 0.308324305774844 0.438421328916654 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FTH1 1.01625969599356 0.0009672467444537 0.152420763103627 0.961176016764867 0.0020096731608115 0.223491901031981 0.470691091260586 0.487225213110551 2.0 -0.137296675201236 0.778731824221179 0.603615833367839 0.107552743696813 0.466319158166603 0.22379678552763 partial_or_other True True False False False False False 2 cross_species_direction_conflict +LINC02268 0.942371404524534 0.0010734592107202 0.154668779872222 0.695412948708723 0.0171152952693119 0.326204572615871 0.419841999990531 0.086467881626737 2.0 True True False False False False False 2 insufficient_or_context_specific +ATP8A1 -1.38165873302663 0.0010943749147997 0.154668779872222 -1.14210373781565 0.010277716240175 0.302245517751671 0.215749419452351 0.615020499249643 -0.257209720879295 0.439529328416457 -0.0414603014269436 0.922845826959116 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TNFAIP8L3 1.72284200517546 0.0010987079456731 0.154668779872222 1.60179102247684 0.0027772714758077 0.224500148429329 0.89724755346469 1.00243667590439 0.0894088362931191 3.0 True True False False False False False 2 insufficient_or_context_specific +TOLLIP -1.04247920363411 0.0011229097894121 0.155995809955445 -0.910624004267048 0.0059417953907212 0.266950960575468 -0.134435033461508 0.655409812639629 0.38339996651245 0.101615133548941 0.248964933050941 0.311918322462647 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ABCA9-AS1 1.88269329327869 0.0012254124210814 0.164558653805348 1.94476060497384 0.0008614886639779 0.177355916186346 0.0563383669842103 1.0 True True False False False False False 2 insufficient_or_context_specific +ASMTL-AS1 -1.27545862090947 0.0012525278333339 0.164558653805348 -0.862065248443666 0.0387245363973537 0.379484931484566 False True False False False False False 2 insufficient_or_context_specific +MAK 1.53801865885918 0.0012571313664047 0.164558653805348 1.37886244279112 0.004234673290942 0.255483889175805 0.0584415939001511 1.0 True True False False False False False 2 insufficient_or_context_specific +DCDC2 2.918772146163 0.001284903140568 0.164558653805348 1.93184173587011 0.018033578245955 0.32629129734252 True True False False False False False 2 insufficient_or_context_specific +AL122035.1 1.25891282950103 0.0013338280500393 0.164558653805348 1.0064675258064 0.0112216047009535 0.302570357129259 0.0371891227503263 1.0 True True False False False False False 2 insufficient_or_context_specific +ELOVL6 -0.803233042240617 0.0013440572822873 0.164558653805348 -0.672214512741747 0.0081339576442935 0.287862310479138 0.621679941401149 0.220638627693788 -0.0744102356612982 0.879367015068648 0.547269705739851 0.243101851038888 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC087286.2 1.62349166228617 0.0013654172452521 0.164558653805348 1.34566348879156 0.0088905238894568 0.291509786412688 0.0671229596077139 1.0 True True False False False False False 2 insufficient_or_context_specific +LINC01088 2.62750809051594 0.0013715818843408 0.164558653805348 2.73258077632421 0.0009213664661906 0.180144206482238 0.218970281911424 1.0 True True False False False False False 2 insufficient_or_context_specific +ATF5 -1.41520181309932 0.0014300519495602 0.165917455862169 -1.49350324096231 0.0006231093284699 0.170662739118283 0.137843275114364 0.825890531343763 -0.415767175238163 0.356329813599554 -0.277923900123798 0.571099263176657 partial_or_other False True False False False False False 2 insufficient_or_context_specific +NWD2 -2.41602011589928 0.0015409334479707 0.166011993302809 -1.92557385779217 0.0148364047851481 0.319028027946219 False True False False False False False 2 insufficient_or_context_specific +DHX40 0.7689542531063 0.0016782416718989 0.174045466133974 0.57734416262441 0.0211696367985884 0.337626926464496 0.9523091780774631 0.0517336978858743 2.0 -0.433166062234664 0.185128860286101 0.203254974900496 0.477545063263485 -0.229911087334168 0.447637017828684 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CCDC39.1 2.37539512471476 0.0017029585121612 0.174045466133974 2.85095302544486 0.0006592179472267 0.170662739118283 True True False False False False False 2 insufficient_or_context_specific +CLIP2 -0.754145424421516 0.0017045677580794 0.174045466133974 -0.559326325845762 0.0261872566434732 0.354014155751332 0.314411592150691 1.0 0.175945704132878 0.597847856752033 -0.804366126562053 0.0114384602136389 -0.628420422429175 0.0406004142770348 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RPAP3 -0.745511495791371 0.0017623503238764 0.175448047823497 -0.617726833727849 0.0114031456255583 0.303576144732418 0.463645894571488 1.0 -0.0287411984778429 0.968993547007747 -0.303561697344886 0.528871735766269 -0.332302895822729 0.5572780050764 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC006059.1 1.32275290724448 0.0018366620319238 0.177903465440841 1.36883224922696 0.0012416277838346 0.187272944881803 0.0889727654741666 1.0 True True False False False False False 2 insufficient_or_context_specific +DENND2A -0.637395823542949 0.0018955477236261 0.179665930369822 -0.569508830402271 0.0062747346046491 0.27151085227822 0.492426772813704 1.43130563512817 2.0 -0.165539259334223 0.623404071853867 0.0984969520083733 0.72951318681034 -0.06704230732585 0.83425899614938 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PCDH11X -1.97129653180139 0.0019229257559945 0.179665930369822 -2.00539388318988 0.0016435102617846 0.20851373013042 0.012800047336533 0.9889960075238 0.477327437564119 0.363250610358758 0.490127484900652 0.421954105579227 partial_or_other False True False False False False False 2 insufficient_or_context_specific +OPLAH -2.00696526943294 0.0019748801917507 0.181311174473953 -2.07583316612107 0.0011338124111986 0.187272944881803 -0.398041116094973 0.36201245308233 0.613572309022348 0.1045607216691 0.215531192927375 0.595637129004598 partial_or_other False True False False False False False 2 insufficient_or_context_specific +NOTCH1 -1.01163672476076 0.0020076246683243 0.181402228472185 -0.846200023015568 0.0156214938657294 0.320853404849916 -0.395549061897442 0.181626715567711 0.0674139197476292 0.812414984824247 -0.328135142149813 0.229137443039796 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC010894.3 1.21257408610248 0.002010234962232 0.181402228472185 1.47729103398578 0.0001695964380585 0.11191244956391 0.040230256457768 1.0 True True False False False False False 2 insufficient_or_context_specific +LINC00607 1.68919390290835 0.0021229508901428 0.188353911748976 1.09412473183218 0.0443150642883953 0.393650849907072 0.7759891459411329 0.0321550569603752 2.0 True True False False False False False 2 insufficient_or_context_specific +C2ORF42 -0.659479028416954 0.0021577886665366 0.189522964316394 -0.734512605135767 0.0004686033508113 0.159716393962721 False True False False False False False 2 insufficient_or_context_specific +CDH4 -2.60927093565762 0.0022728843325943 0.195098477914886 -2.28991022069826 0.0082885150961979 0.287862310479138 False True False False False False False 2 insufficient_or_context_specific +SCN7A 2.48350111223709 0.0023885583822185 0.201379514324843 0.998354258542244 0.221601565373326 0.592957341103408 0.484070309152975 0.305155175594481 2.0 2.42373546564407 0.136469840319014 1.8285323129781 0.0170014454933291 4.25226777862217 0.0049974039783899 partial_or_other True False False False True False True 2 residual_state_candidate +PHF19 0.922408320951622 0.002452035747225 0.201379514324843 1.0601585565883 0.0003977216352695 0.149969465184837 0.442096400724116 0.0278869326105961 2.0 True True False False False False False 2 insufficient_or_context_specific +EIF4G1 -0.812840117854313 0.0024578604978549 0.201379514324843 -0.689675836287985 0.0135530856283874 0.313114831651016 0.100315558879533 1.0 0.0534010541850421 0.892629597980248 0.0881144189252419 0.759537105322109 0.141515473110284 0.640880182658275 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PGS1 -0.781131124808477 0.0024613927640237 0.201379514324843 -0.664852899989947 0.0116917080390457 0.305645553145081 1.50829766810927 1.0 0.31957522957108 0.289362681675201 -0.670812112740399 0.0210308404381505 -0.351236883169318 0.209384326395718 partial_or_other False True False False False False False 2 insufficient_or_context_specific +KIF6 -1.38242502586093 0.0025768646592741 0.205792288718135 -1.07421548657564 0.0227853979758782 0.346028040476539 1.10214184653955 1.0 False True False False False False False 2 insufficient_or_context_specific +ALOX12-AS1 0.853816393626159 0.0026608484959193 0.208098062369754 0.6363861071034 0.0283988232950747 0.366994830293022 0.0656529843866426 1.0 True True False False False False False 2 insufficient_or_context_specific +NDST1 -0.642022550154642 0.0027224311666489 0.209978919106319 -0.641540560504575 0.0027199318359242 0.224500148429329 0.929345147536502 1.0 0.0257177406162219 0.943239121657695 -0.0709618425076892 0.787892808463223 -0.0452441018914673 0.880723142804764 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RPS5 1.3229360479383 0.0027504461921223 0.209978919106319 1.36363643289061 0.0021448236123812 0.223491901031981 0.8592203889091701 0.644909773787938 0.00945594269725729 3.0 True True False False False False False 2 insufficient_or_context_specific +HSPA4L 1.15204309394415 0.0027843387644331 0.209978919106319 0.851930050858464 0.0290615933629793 0.369232614592462 0.291034924485405 1.0 -0.319231373518889 0.311457089989061 -0.236467672976573 0.386749292494731 -0.555699046495462 0.0654255849760873 partial_or_other True True False False False False False 2 cross_species_direction_conflict +AC007221.2 -1.84393569856201 0.0029987991728849 0.212953915711243 -1.38576459334181 0.0327504784211063 0.375031405408838 False True False False False False False 2 insufficient_or_context_specific +GLYCTK -1.91128708851884 0.0030088152922884 0.212953915711243 -1.81403585939021 0.00547555097059 0.265300960238175 -0.508861172520065 0.202945463603968 0.432667799926242 0.218459201873378 -0.0761933725938235 0.856202437093372 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CCDC82 0.609836388287407 0.0030404887465665 0.212953915711243 0.736661169086489 0.0001967618058987 0.115411730371065 0.0633525233691126 1.0 -0.0613108036313068 0.885130826731918 -0.372019508765776 0.204590862502895 -0.433330312397083 0.164751485528255 partial_or_other True True False False False False False 2 cross_species_direction_conflict +LINC02211 3.08138683019423 0.0030546458282581 0.212953915711243 2.73249700038922 0.0055996106377765 0.265300960238175 0.0520485713801089 1.0 True True False False False False False 2 insufficient_or_context_specific +DNM2 -0.590554848553834 0.0031014351610137 0.212953915711243 -0.619323095062641 0.0016112706548404 0.207460921631778 0.380668377689919 1.0 -0.247923648165972 0.394091937703044 -0.23275607937071 0.34881777895503 -0.480679727536683 0.0768010470857484 partial_or_other False True False False False False False 2 insufficient_or_context_specific +UBTF -0.79608712720908 0.0031541818901262 0.212953915711243 -0.587119580287839 0.0454975800268549 0.396012736952625 0.066576805897466 0.841493267088372 -0.324307649260813 0.167705559372267 -0.257730843363347 0.29875103833365 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AKAP1 -0.951965692100113 0.0031572697383267 0.212953915711243 -0.9061533174546 0.0054445987532647 0.265300960238175 0.47287061107482 1.0 -0.505848027607496 0.177080018356975 0.690766589641088 0.0441542443912198 0.184918562033592 0.601567421749537 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ERCC3 -0.534947592827453 0.0031647727072973 0.212953915711243 -0.436830506042972 0.0207232099006964 0.333389311130767 0.158673013786897 0.526349666571007 -0.311711767966901 0.12803586638623 -0.153038754180004 0.49024480906257 partial_or_other False True False False False False False 2 insufficient_or_context_specific +DDX42 -0.497475755004029 0.0032248981900584 0.212953915711243 -0.364266775591253 0.0393763821916719 0.379484931484566 0.0226843273854183 0.953538572668654 -0.279554266610821 0.276926228517841 -0.256869939225403 0.355942804915087 partial_or_other False True False False False False False 2 insufficient_or_context_specific +LINC01376 0.690217896621866 0.0032600412786551 0.212953915711243 0.672128224228794 0.0044785490011592 0.261521011602645 0.96815824609648 0.0733435270085569 2.0 True True False False False False False 2 insufficient_or_context_specific +ZNF398 -0.679160268931099 0.0032661597518546 0.212953915711243 -0.495177516268399 0.049125439016051 0.404177169779245 False True False False False False False 2 insufficient_or_context_specific +DAGLB -0.621915456526043 0.003274872220042 0.212953915711243 -0.594843944776898 0.0051533352959384 0.265121723850427 0.421448043468066 1.0 -0.55390327933687 0.103525571210266 0.577797523816756 0.0604351196850955 0.0238942444798857 0.947234378994418 partial_or_other False True False False False False False 2 insufficient_or_context_specific +BRD2 -0.640061973022121 0.003282742475273 0.212953915711243 -0.672038790577188 0.0017078725255453 0.209671140984979 0.564765314435796 1.0 0.0020403323834129 0.996617940730295 -0.260999447977043 0.355408290279068 -0.25895911559363 0.388409100116023 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FAM99A -1.72253651889191 0.0033081260470119 0.212953915711243 -1.49299358638067 0.0128720560722908 0.313114831651016 0.5900020314223521 1.0 False True False False False False False 2 insufficient_or_context_specific +AC105094.2 1.43028643978985 0.003310751277847 0.212953915711243 1.19595861350121 0.0133108976033998 0.313114831651016 0.0370846605454504 1.0 True True False False False False False 2 insufficient_or_context_specific +RRBP1 -0.914499710552836 0.0033184675036604 0.212953915711243 -0.818344177150809 0.0105864097362195 0.302245517751671 -0.262476377299628 0.48851729371843 0.15068860878971 0.648804791198865 -0.111787768509918 0.758520501576551 partial_or_other False True False False False False False 2 insufficient_or_context_specific +EGLN3 1.31243548193876 0.0033280352426932 0.212953915711243 1.02732170060632 0.0217347434435169 0.343012587857476 0.4522612286994939 0.8044794378447421 0.0938516797781893 3.0 -0.597084422790578 0.162134025041414 -0.198248567474643 0.608826866432889 -0.795332990265221 0.0577160147529464 partial_or_other True True False False False False False 2 cross_species_direction_conflict +SLC13A5 -1.94765177584746 0.003374116388919 0.21424167471499 -2.08449786006548 0.0014657544749015 0.206339143280147 False True False False False False False 2 insufficient_or_context_specific +HTR2B 2.07765885254163 0.003392446674168 0.21424167471499 2.38112153589689 0.0008396539972777 0.177355916186346 0.0518449463089271 1.0 True True False False False False False 2 insufficient_or_context_specific +PRELP 1.42384213148235 0.0035192942792347 0.21424167471499 0.879952366524123 0.0717922129939853 0.446899163045108 0.943481383144937 1.4723058219959 0.120826282483261 3.0 0.139029736398976 0.728481709598663 0.948614073532196 0.010323963864778 1.08764380993117 0.0078119300748938 partial_or_other True False False False True False True 2 residual_state_candidate +HEXDC -1.05973292005237 0.0035694599314627 0.21424167471499 -1.10886542262198 0.0021005325728856 0.223491901031981 0.0503223269737841 0.911240264788933 -0.724406937231652 0.0298413099751986 -0.674084610257868 0.0559117026839348 partial_or_other False True False False False False False 2 insufficient_or_context_specific +WDR46 -1.10948950024833 0.0035724185580639 0.21424167471499 -0.914010252807871 0.0214897118482734 0.340673239780887 -0.11236470148734 0.765205545586392 -0.23196512448012 0.406132870156738 -0.34432982596746 0.249216474222944 partial_or_other False True False False False False False 2 insufficient_or_context_specific +OAF -0.9174098403884 0.0035803970794779 0.21424167471499 -0.821782932570235 0.011260235035775 0.302570357129259 -0.969779398008457 0.0095641670674209 0.632335764891623 0.0468500666462594 -0.337443633116834 0.275756364681384 reversed False True False False False False False 2 insufficient_or_context_specific +CDC42EP4 -1.0026192957992 0.0036063701773753 0.21424167471499 -1.02021406129606 0.0028280469540728 0.224500148429329 0.281256471480132 1.0 -0.235147687205268 0.506924940457442 0.742416727897399 0.0225670741939282 0.507269040692131 0.103724522165949 partial_or_other False True False False False False False 2 insufficient_or_context_specific +STMN2 3.41259726333696 0.0036290183224424 0.21424167471499 3.20548880863489 0.0046131063505294 0.261521011602645 0.7116668294632509 0.7572579702804899 0.0500030961583266 3.0 True True False False False False False 2 insufficient_or_context_specific +PLPP4 1.65461010601298 0.0036330748979082 0.21424167471499 1.82667965506565 0.0012309447935518 0.187272944881803 0.329783960867872 0.967487403639645 0.171300271999776 3.0 True True False False False False False 2 insufficient_or_context_specific +TSHZ3 0.605394601319377 0.0036872857356134 0.21424167471499 0.443856574513159 0.0369419556678866 0.379040979535031 1.40857164761387 0.143416611109619 0.118149940311462 3.0 -0.0063545895093254 0.987789340542948 0.307197425250504 0.233741203762072 0.300842835741179 0.284820978997797 partial_or_other True True False False False False False 2 cross_species_direction_conflict +COL19A1 -1.53967562738124 0.0036915690510173 0.21424167471499 -1.4207102961162 0.0080530379074986 0.287862310479138 False True False False False False False 2 insufficient_or_context_specific +CCDC71L 1.2439834483501 0.0037537514356979 0.21424167471499 0.950982642096094 0.0259999473571606 0.353316498154592 0.5555561985123111 0.834789547182785 0.0696354908548192 3.0 -0.226835907266435 0.43489467448857 -0.615681271555682 0.0246079859153381 -0.842517178822117 0.0093579283120773 partial_or_other True True False False False False False 2 cross_species_direction_conflict +AL445250.1 1.23074138292112 0.0038068877090582 0.21424167471499 1.42726514789044 0.0005054672032769 0.161718870672667 0.37135133808192 0.36544907779802 2.0 True True False False False False False 2 insufficient_or_context_specific +PLCB4 1.76878976821892 0.0038358395385522 0.21424167471499 2.10550608784764 0.0004840159953317 0.159716393962721 0.264805564326409 0.373755036992867 0.2667121247090861 3.0 -0.222061775843987 0.58160692122352 -0.078696947752956 0.816441668016588 -0.300758723596943 0.382791083076601 partial_or_other True True False False False False False 2 cross_species_direction_conflict +AC098829.1 1.05568316951029 0.0038769192750339 0.21424167471499 1.29583756237397 0.0002989706439809 0.143478729961412 0.273755273584595 0.232871539767532 2.0 True True False False False False False 2 insufficient_or_context_specific +CBWD5 0.707886185148029 0.0039494057847905 0.21424167471499 0.687609561715996 0.0053453076406047 0.265300960238175 0.0418830059517512 1.0 True True False False False False False 2 insufficient_or_context_specific +SEL1L3 1.13019860233059 0.0039638319580347 0.21424167471499 1.01676043512808 0.0106775776304568 0.302391883062908 -1.13814414875927 0.0276684773765074 0.584971661749681 0.174140748094176 -0.553172487009584 0.206075766271165 reversed True True False False False False False 2 cross_species_direction_conflict +ODF2 -0.625514628756823 0.0039793214516015 0.21424167471499 -0.633813775945338 0.0033582702112956 0.239571735749052 0.166211383257963 0.628890288992641 -0.714865582052542 0.0206527802223845 -0.548654198794579 0.0710172350507653 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CFTR 2.55687576998957 0.0040237305616373 0.21424167471499 1.73700277440789 0.0393552573567406 0.379484931484566 True True False False False False False 2 insufficient_or_context_specific +PPM1G -0.747261693720141 0.0040356544682126 0.21424167471499 -0.611862932428283 0.0239356461139945 0.348898908348731 -0.0406458536949318 0.908928135185546 0.128194226422189 0.598329732058544 0.0875483727272568 0.751477221714239 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CAPN5 -1.18623334598897 0.0040585763327478 0.21424167471499 -1.169192303032 0.0048224045252735 0.261521011602645 -0.320373761361765 0.30823413991577 -0.419650615085315 0.127659683438118 -0.74002437644708 0.0247189928973452 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AMPH -1.43252315927275 0.0040625953600232 0.21424167471499 -1.02102073327802 0.0488604326972906 0.404047580308211 False True False False False False False 2 insufficient_or_context_specific +RPL18 1.21071624091382 0.0041173678404876 0.21424167471499 1.40977823117958 0.0006627365319046 0.170662739118283 0.0100080541072106 1.0 True True False False False False False 2 insufficient_or_context_specific +PARP1 -0.629974784575299 0.0041290651238917 0.21424167471499 -0.641287784459189 0.0033556089348578 0.239571735749052 0.415652221475556 1.0 -0.112949431151017 0.695339752224939 0.0413772052659175 0.869885889626989 -0.0715722258851 0.785362332771755 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CLPTM1L -1.14510319065146 0.0041575805479564 0.21424167471499 -1.13235632054541 0.0047241416666747 0.261521011602645 0.301550298867203 0.316513871853418 0.0651731959324424 0.816723102809629 0.366723494799646 0.180860734281678 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CLIP4 1.04963387887393 0.0041983731141061 0.21424167471499 0.778245393249437 0.0384463062260527 0.379484931484566 0.291831585531263 0.204245897239553 2.0 -0.522962154971975 0.123649386882651 -0.380724790485269 0.205789311661792 -0.903686945457244 0.0166736033483081 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CNKSR2 1.75313671899969 0.0042061645259134 0.21424167471499 1.86837107801622 0.0023103743794663 0.223491901031981 0.135358755889696 1.0 True True False False False False False 2 insufficient_or_context_specific +LINC01500 1.38494170805569 0.0043445496067918 0.216366767681645 1.09651982413896 0.0242294122024839 0.349408136686844 0.542155231384652 0.42223170797523 0.0247227933793546 3.0 True True False False False False False 2 insufficient_or_context_specific +AP003086.2 1.17844482213984 0.004445841553028 0.219692720708544 1.01889812602654 0.0149004342583547 0.319105040364522 0.0384200656599304 1.0 True True False False False False False 2 insufficient_or_context_specific +AP3D1 -0.742844861674951 0.0045214805803006 0.220246576897599 -0.702118901511092 0.0080664575130149 0.287862310479138 0.42728850576217 1.0 -0.0205258887296951 0.951047630284453 -0.512370564013937 0.0383411651842633 -0.532896452743632 0.0396757426500509 partial_or_other False True False False False False False 2 insufficient_or_context_specific +GFOD2 -1.02049959366258 0.0045390484999266 0.220246576897599 -0.911893153421879 0.0130206478826189 0.313114831651016 False True False False False False False 2 insufficient_or_context_specific +AC004076.1 0.828712832063224 0.004610200179425 0.220246576897599 1.00610020311746 0.0003564927741363 0.148975599106358 0.0297130692013619 1.0 True True False False False False False 2 insufficient_or_context_specific +ARHGEF10L -0.811776490665151 0.0047833011302395 0.221799407601324 -0.725227577980446 0.0135262944827871 0.313114831651016 0.427969042916184 0.4163180250189221 2.0 0.357816871581043 0.160798809911724 -0.659697612463488 0.011607751173525 -0.301880740882444 0.207496333256401 partial_or_other False True False False False False False 2 insufficient_or_context_specific +NCOA7 0.62100141845027 0.0047890968050942 0.221799407601324 0.566067664159013 0.0114725214764382 0.303576144732418 0.236342312493517 0.15006912596093 2.0 -0.0775258594926695 0.853475807498588 -0.469589801852081 0.114173315998268 -0.547115661344751 0.0896926984395467 partial_or_other True True False False False False False 2 cross_species_direction_conflict +UPF3B -0.497010058061256 0.0047897579970734 0.221799407601324 -0.406319351352446 0.029462722266017 0.371202173847981 -0.274971440843875 0.31911265086607 -0.395237370067488 0.104315604348998 -0.670208810911363 0.0211333578204833 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FLII -0.786080550699717 0.0048499146407664 0.22360436147254 -0.615500714420752 0.0346333794133852 0.37720666979567 -0.266454236455085 0.337773047283926 -0.18759597774278 0.435694026991303 -0.454050214197865 0.0824274833311042 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CCNJL -1.72908316934802 0.0049652443622378 0.225335037453351 -1.10905905723676 0.0898098078866896 0.470810303707879 -0.955595635928151 0.05092953593 -0.171261211964358 0.705586875829981 -1.12685684789251 0.0248774099173533 persistent False False False False False True False 2 insufficient_or_context_specific +OPA3 -0.773129131326632 0.0049689947640323 0.225335037453351 -0.779833057131563 0.0045352951110983 0.261521011602645 0.308211818669253 0.418699820073183 -0.0539613724515754 0.877872898258553 0.254250446217677 0.458698542662427 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC009690.1 0.597899573712241 0.0049803908170844 0.225335037453351 0.495000451641488 0.0232383527252121 0.346051520554005 0.100234281455222 0.09963903494570499 2.0 True True False False False False False 2 insufficient_or_context_specific +TRPC4 2.24308749998491 0.0049941654445997 0.225335037453351 2.18071917462656 0.0063960082525578 0.274508354189049 0.393848900398942 0.384353637647677 2.0 True True False False False False False 2 insufficient_or_context_specific +SYT10 -1.79855586436455 0.0050931032768767 0.227474198558781 -2.03429930321659 0.0013317969600676 0.19529322644992 False True False False False False False 2 insufficient_or_context_specific +ZNF540 0.901478429745445 0.0052075110832754 0.229265285907992 0.66586373194141 0.0458104677451579 0.396773518009333 0.0230877473966388 1.0 True True False False False False False 2 insufficient_or_context_specific +ALLC -0.945899389052459 0.0053668615166649 0.229265285907992 -0.922461209206435 0.0068864238687046 0.282692791660547 0.3462519993284099 0.632413336466447 2.0 False True False False False False False 2 insufficient_or_context_specific +PPP6R2 -0.522695095733294 0.0053911870984274 0.229265285907992 -0.580889998083522 0.0015139352258585 0.207460921631778 -0.276275557475997 0.35558893641133 -0.0362108708571504 0.904199032444404 -0.312486428333147 0.247369938682454 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TXLNA -0.598488719658943 0.0054161720627482 0.229265285907992 -0.585405263079274 0.006705721956822 0.28094846198463 0.41840273171083 1.0 -0.263382177900164 0.370232091268869 -0.478814548336226 0.0697697586762225 -0.74219672623639 0.0172648698473128 partial_or_other False True False False False False False 2 insufficient_or_context_specific +C3 -1.07318791397998 0.00547804082187 0.229265285907992 -1.07653641834912 0.0053187162892821 0.265300960238175 -1.47128937590391 0.0212560651457436 0.80311775047928 0.133899714737055 -0.668171625424625 0.22428246877682 reversed False True False False False False False 2 insufficient_or_context_specific +TMEM178B 1.64022761662547 0.0054829807611031 0.229265285907992 2.01277103939634 0.000722275140541 0.173313203041643 1.06835309984622 0.152561058758132 2.0 True True False False False False False 2 insufficient_or_context_specific +UFL1 0.486405308115717 0.0055021247642186 0.229265285907992 0.369662352623732 0.0374323267692754 0.379484931484566 0.0506355418814507 1.0 -0.076365593687197 0.777578240653188 -0.429995981972735 0.0451338338564942 -0.506361575659932 0.0312610155113001 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CCDC58 0.766591969894334 0.0055447031191468 0.229265285907992 0.599568615366598 0.0299155356907475 0.372462530451547 0.0110853164657539 1.0 -0.332076309219795 0.350855810852779 0.388066465394524 0.196130965826194 0.0559901561747286 0.880689391110528 partial_or_other True True False False False False False 2 cross_species_direction_conflict +RTKN -0.856708513705282 0.0055538871175079 0.229265285907992 -0.659214089997159 0.0429326390302135 0.391483132487066 0.319382920030133 0.378413320842395 -1.06667442148732 0.0060349363502649 -0.747291501457186 0.041688969772708 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RMDN2 -0.514944638848625 0.005558359015209 0.229265285907992 -0.438832429238193 0.0193528851193896 0.330467462546779 -0.288589073150948 0.359622010647502 0.422602425522143 0.114270430894695 0.134013352371195 0.654202486403616 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FAM227B 0.943988170908024 0.0055993469479234 0.229265285907992 0.81864171753679 0.0184329253645093 0.327267058068343 0.302048499682027 0.0721110890064239 2.0 True True False False False False False 2 insufficient_or_context_specific +CCDC102B 1.3094945928262 0.005602428846776 0.229265285907992 1.46580108237091 0.0014627979404767 0.206339143280147 1.90924920316958 0.402270429569155 0.3899277847610539 3.0 True True False False False False False 2 insufficient_or_context_specific +PRKD3 0.51030889750395 0.0057071294613864 0.231589375580443 0.426263258369319 0.0237054125589424 0.348898908348731 0.270133428098472 1.0 -0.251720994134025 0.497627947413535 0.62966368359499 0.0515085319770978 0.377942689460965 0.236963675631342 partial_or_other True True False False False False False 2 cross_species_direction_conflict +C8ORF59 0.834487779337782 0.0058219104058008 0.232609124179994 0.792869745122542 0.0086847515807456 0.291509786412688 0.035090490926751 1.0 True True False False False False False 2 insufficient_or_context_specific +MORN1 -0.805823256125243 0.0059062271950484 0.232609124179994 -0.715937492577549 0.0151445923298459 0.320500116612027 -0.351612638011165 0.496836189572497 0.0608091723548366 0.899903010515023 -0.290803465656329 0.530928784133368 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FAM153A 2.42788926826415 0.0059204479539914 0.232609124179994 1.68452162385956 0.0490631242583068 0.404177169779245 0.119381571586278 1.0 True True False False False False False 2 insufficient_or_context_specific +ZNF727 1.33791295506183 0.0059401043988571 0.232609124179994 1.30119795341262 0.007636371407371 0.287862310479138 0.0329352199692422 1.0 True True False False False False False 2 insufficient_or_context_specific +BAIAP2L2 0.962937827248947 0.0059424207637603 0.232609124179994 1.09281969105155 0.0016786954973561 0.20851373013042 0.0351785962871467 1.0 True True False False False False False 2 insufficient_or_context_specific +ACAP3 -0.990734496260326 0.0059558787410415 0.232609124179994 -0.838224005144893 0.0228741366232256 0.346028040476539 0.634932019643347 0.0820985936981809 -0.93665543339308 0.0119249432249266 -0.301723413749733 0.377916846535421 reversed False True False False False False False 2 insufficient_or_context_specific +USP10 -0.44059920971815 0.0059705505448738 0.232609124179994 -0.327683307872122 0.0429092531570849 0.391483132487066 0.0029627083370796 0.994391605827221 0.215268034851461 0.429364303827733 0.218230743188541 0.458615014031944 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SLC14A2 1.4188963135771 0.0061188789360118 0.23664147914437 1.29395482593397 0.0119353300835137 0.306601496403255 1.52607975035302 1.38747497598338 0.0451679503475701 3.0 True True False False False False False 2 insufficient_or_context_specific +RPS19 0.82382141362142 0.0061788803851976 0.236788351127249 1.0858540201072 0.0001591970082018 0.11191244956391 0.126962833202674 1.0 True True False False False False False 2 insufficient_or_context_specific +TRIM23 0.577354073461113 0.0061899587905967 0.236788351127249 0.461189877325906 0.0314102640414864 0.375031405408838 0.0411402863930078 1.0 -0.0496527591494681 0.932224167680262 -0.263344674447323 0.488408012368444 -0.312997433596791 0.457227563198328 partial_or_other True True False False False False False 2 cross_species_direction_conflict +MT1H -1.8834645854408 0.0062998572967051 0.237387459486941 -1.92015498883229 0.0051816270922837 0.265121723850427 False True False False False False False 2 insufficient_or_context_specific +NEBL 1.51033745337555 0.0063544705065595 0.237387459486941 1.48014354335583 0.0075951030195503 0.287862310479138 True True False False False False False 2 insufficient_or_context_specific +AXIN1 -0.823363541316491 0.0063752396449078 0.237387459486941 -0.783458612843316 0.0107140030928058 0.302455734368565 0.289946691078157 1.0 0.320368523487676 0.326527528213087 -0.0543269037691358 0.858292735927124 0.26604161971854 0.372690537159597 partial_or_other False True False False False False False 2 insufficient_or_context_specific +C12ORF76 0.658862419753839 0.0064531063596589 0.237387459486941 0.618353724645937 0.0114328740331659 0.303576144732418 0.770541225416834 0.0157170618889642 2.0 True True False False False False False 2 insufficient_or_context_specific +MARCH2 -0.831999705459654 0.0064731754403172 0.237387459486941 -0.741522085471011 0.0166781321108018 0.325489753822016 0.468993534052236 0.572126619419662 2.0 -0.0329358633665881 0.926507226037505 0.269753620341024 0.247839306380207 0.236817756974436 0.345365011755673 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC011604.2 -2.72256732555364 0.0064848545953712 0.237387459486941 -3.01014257672479 0.0024699573053183 0.224500148429329 False True False False False False False 2 insufficient_or_context_specific +DGCR8 -0.560684242280821 0.0064917416804538 0.237387459486941 -0.477635513453513 0.0224983698000492 0.346028040476539 0.501555671364892 0.125190920694517 -0.410680300975884 0.143360777460151 0.0908753703890082 0.788459032075034 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ADCY3 -0.865084500857214 0.006498324443923 0.237387459486941 -0.778335353564508 0.0176254036198476 0.326204572615871 0.894768906524331 0.0130436761962113 -0.465888316310695 0.0944001297673573 0.428880590213636 0.172318973292997 reversed False True False False False False False 2 insufficient_or_context_specific +TRIM11 -0.831937372881861 0.0065230874425365 0.237387459486941 -0.6881492164574 0.0283895720118802 0.366994830293022 -0.646117989473747 0.149029449922273 -0.428480952041373 0.283314717682934 -1.07459894151512 0.0240088670253366 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CFAP97 -0.736763836631377 0.0065448127929918 0.237387459486941 -0.700801959649059 0.0103503361731067 0.302245517751671 0.0919137823813148 0.868855565568195 0.186830837727648 0.605585516868598 0.278744620108962 0.498962874685992 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TAZ -0.525596338599426 0.0066132033192655 0.237387459486941 -0.429651696125708 0.0322167310689656 0.375031405408838 -0.304535796664047 0.207206240520833 -0.243078748895323 0.251882687108528 -0.54761454555937 0.0279752979233303 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZNF787 -0.953788921342058 0.0066328187676309 0.237387459486941 -0.967561672982875 0.0057242162771714 0.265907216454356 0.0895451130913796 1.0 False True False False False False False 2 insufficient_or_context_specific +ANGPTL6 -1.0789516134697 0.0066711806611755 0.237894076830444 -1.24612436621641 0.0009964320460221 0.186944419865129 0.354414529864641 1.0 -1.33909669508539 0.0069491880022759 1.29368439739152 0.0069363230319811 -0.0454122976938668 0.922845826959116 reversed False True False False False False False 2 insufficient_or_context_specific +AGPAT3 -0.517295813239786 0.0066920383423604 0.237894076830444 -0.435004752419931 0.0270446937259566 0.356222495883986 -0.22444617172448 0.518394088051918 -0.0336262647950643 0.920450783515341 -0.258072436519544 0.391855888403995 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SAE1 -0.627619427601152 0.0067256995328305 0.238288374723573 -0.61207358385774 0.0085857492060203 0.291509786412688 0.633872947738206 0.0303078413777563 -0.466926993813485 0.0627594321974505 0.166945953924721 0.539821382220508 reversed False True False False False False False 2 insufficient_or_context_specific +AC100849.1 -1.55002026653011 0.0068901280703021 0.240880702537252 -1.15179840948067 0.0493222273647475 0.404304407233699 False True False False False False False 2 insufficient_or_context_specific +GNE -0.568882841857916 0.0069428784167698 0.240995195720413 -0.559953560930711 0.007925602318032 0.287862310479138 -1.10398215513571 0.0022034593158533 1.13109293930297 0.0019705767786685 0.0271107841672526 0.92923636652208 reversed False True False False False False False 2 insufficient_or_context_specific +ZFPM1 -1.27660698248742 0.0070504922991985 0.240995195720413 -1.28985323180043 0.0062618831061178 0.27151085227822 0.2755153709691061 1.0 -0.342436411360969 0.474725275062832 0.679343184803671 0.0810238079677809 0.336906773442702 0.409548955957634 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZNF766 0.521874952305711 0.007090808729986 0.240995195720413 0.483966858956391 0.0126685471971323 0.313114831651016 0.530335522097099 1.0 True True False False False False False 2 insufficient_or_context_specific +RAI1 -0.678499102290013 0.0071695933198788 0.240995195720413 -0.556374650313809 0.0354686213587202 0.37720666979567 0.460236836584569 1.0 0.0617191276437482 0.858538506679468 -0.648592729819997 0.0185781377373433 -0.586873602176249 0.035665069179295 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RERG 1.03824349576853 0.0071758450564369 0.240995195720413 0.883794205042141 0.0264412922142841 0.354273049744177 0.430295898486267 0.247733810841872 2.0 -0.262312343462182 0.495330805341603 -0.0025146592843489 0.995670725631231 -0.264827002746531 0.432306077638545 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CERS4 -0.529236336840536 0.0071778007633155 0.240995195720413 -0.438458718786847 0.035480077297695 0.37720666979567 0.0848847856267105 0.865711176141888 -0.485884309489179 0.164350789764517 -0.400999523862468 0.28559778036183 partial_or_other False True False False False False False 2 insufficient_or_context_specific +F7 -1.47868087543224 0.0072079575358256 0.240995195720413 -1.23560186268482 0.0316092926910961 0.375031405408838 -1.35336338198313 0.0039207200368319 0.887231101050937 0.0230224665365736 -0.466132280932195 0.194062992971038 reversed False True False False False False False 2 insufficient_or_context_specific +C9ORF84 1.27393049716145 0.0072093094148467 0.240995195720413 1.41258920959964 0.0027749076010545 0.224500148429329 0.0544786322352955 1.0 True True False False False False False 2 insufficient_or_context_specific +SEC16A -0.591071234921023 0.0072998849939209 0.240995195720413 -0.547153363571941 0.0147989719022111 0.318872541517439 -0.20066317889787 0.488335954733525 0.358506469647527 0.135673511210536 0.157843290749657 0.544338946509633 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PHF6 0.699297911042837 0.0073115704591494 0.240995195720413 0.515874363653995 0.0444312571048553 0.393650849907072 -0.138882549348063 0.85393026428381 0.399485134373246 0.408606206471751 0.260602585025183 0.651280240515673 partial_or_other True True False False False False False 2 cross_species_direction_conflict +LINC00893 -0.898742010924232 0.0073240614440463 0.240995195720413 -0.842490604760615 0.0133951352857427 0.313114831651016 False True False False False False False 2 insufficient_or_context_specific +ICAM1 -1.18527683786633 0.0074768561217744 0.244939238945766 -1.12145995049463 0.0121467737465406 0.309429533546452 -0.264099747392064 0.520860017236944 0.116741536663178 0.744639701289962 -0.147358210728886 0.700313558874038 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC093535.1 1.1813875588352 0.0074934053968064 0.244939238945766 1.05798571998338 0.0179320636703751 0.32629129734252 0.0348190589199507 1.0 True True False False False False False 2 insufficient_or_context_specific +AC020637.1 1.97214144158933 0.0075504743127676 0.245680436697702 1.67705713968537 0.0237305350375188 0.348898908348731 0.235129662546124 0.186401350829722 2.0 True True False False False False False 2 insufficient_or_context_specific +TACC2 -0.71874288324342 0.0076126170802026 0.245792082974862 -0.696037862579701 0.0101979666644872 0.302245517751671 0.283962282234301 1.0 -0.296248512381843 0.408165715768595 0.171318282746382 0.577616232440873 -0.12493022963546 0.716715375441809 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FTL 1.14461483639885 0.0076740638930871 0.246580982582269 1.17955611178407 0.005742266087478 0.265907216454356 0.141320823370993 0.41072455664304 2.0 True True False False False False False 2 insufficient_or_context_specific +ANO1 -0.824021213732157 0.0076837604915293 0.246580982582269 -0.663490720782467 0.0394293398218004 0.379484931484566 0.390098457591141 0.303350793900669 -0.527558383026485 0.112833495674879 -0.137459925435344 0.71461344148071 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZNF471 0.751076779401041 0.0077253106237672 0.246996184097737 0.618383346090611 0.0297223637817305 0.371448754340933 0.0466879746680508 1.0 True True False False False False False 2 insufficient_or_context_specific +LSS -1.03304187916373 0.0077760814650179 0.246996184097737 -1.13743627838705 0.0022874586588263 0.223491901031981 0.211525061280242 0.688936764998849 -0.164849632515495 0.689565874743376 0.0466754287647465 0.927489221408977 partial_or_other False True False False False False False 2 insufficient_or_context_specific +DUOX1 1.1167172820706 0.0078262371471231 0.246996184097737 1.00818020933053 0.0168791784684507 0.326204572615871 0.0378023179740467 1.0 True True False False False False False 2 insufficient_or_context_specific +COQ8A -0.567518913591185 0.0078385511941018 0.246996184097737 -0.48453038760182 0.0252399684028038 0.351006805738558 0.150926107683149 0.455189863978223 2.0 -0.997981166878859 0.0282164548122118 0.602991843759433 0.12160887774568 -0.394989323119426 0.320960521871704 reversed False True False False False False False 2 insufficient_or_context_specific +ITGA2 1.81391397938496 0.007860458217166 0.246996184097737 2.57718919125037 0.0001565936351997 0.11191244956391 0.388677706612492 0.110430514098165 2.0 True True False False False False False 2 insufficient_or_context_specific +RANBP10 -0.728112271510729 0.007934832420007 0.248544824907844 -0.791005466985224 0.003016703985463 0.228908329282484 -0.566575710857123 0.0372414718421885 0.352458895888875 0.125392523177066 -0.214116814968248 0.373879874807838 reversed False True False False False False False 2 insufficient_or_context_specific +LINC01446 -2.83719150176907 0.0079568242866879 0.248544824907844 -3.27914093324228 0.001090869446411 0.187272944881803 False True False False False False False 2 insufficient_or_context_specific +SLC4A7 0.896874515550943 0.0081447282950868 0.252298684584913 0.721903136996349 0.0389251085597636 0.379484931484566 0.338129150028275 0.235496515657877 0.122960521771785 3.0 -0.157693414740498 0.759052885175739 -0.297025682069638 0.430013455989002 -0.454719096810136 0.272321963576788 partial_or_other True True False False False False False 2 cross_species_direction_conflict +SLC9A3R1 -0.949061906470634 0.0082933073158843 0.255279121402644 -0.711297540145654 0.0552738326616839 0.421331649096072 -1.15511056119949 0.0082018547692909 -0.0023733195864174 0.996065620952593 -1.15748388078591 0.0095170977344524 persistent False False False False False True False 2 insufficient_or_context_specific +CASP7 -0.507546127806055 0.0083441636287138 0.256097905790582 -0.483393179750891 0.0128103988101292 0.313114831651016 -0.733552329323143 0.0380202656692642 0.448756655955548 0.132229794026787 -0.284795673367595 0.359263061399639 reversed False True False False False False False 2 insufficient_or_context_specific +HS6ST1 -0.837409268037129 0.0083779930764536 0.256198759533081 -0.850223696538646 0.0071926557039374 0.28566724324909 0.0992475751260842 0.445634141704859 2.0 -0.212082014916302 0.546706645992336 0.388410396654433 0.177070162808091 0.17632838173813 0.57335662612511 partial_or_other False True False False False False False 2 insufficient_or_context_specific +DPP9 -0.679882206307667 0.0085018537111309 0.257399450833847 -0.771058994837856 0.0021384290186524 0.223491901031981 -0.433629799476781 0.08130989020184 0.0084372755448573 0.973646999937266 -0.425192523931923 0.0739590701854405 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SGCB 0.763635482896233 0.0085864034860077 0.257787006525209 0.72779073400128 0.0127508403308607 0.313114831651016 0.0294782341544853 1.0 -0.453087754201831 0.163798138742218 0.144942850252409 0.618463360844695 -0.308144903949422 0.302273283654791 partial_or_other True True False False False False False 2 cross_species_direction_conflict +PGPEP1 -0.639513390353474 0.0086008235339478 0.257787006525209 -0.65674459536021 0.0065553151193391 0.277955891686679 0.634467019993728 1.0 0.0446929180983921 0.893567523982346 -0.146914419419306 0.524232761528258 -0.102221501320914 0.696305383272471 partial_or_other False True False False False False False 2 insufficient_or_context_specific +LINC00513 1.02380634470718 0.008606760795087 0.257787006525209 0.934489858951868 0.0180482443361669 0.32629129734252 0.0927634592263186 1.0 True True False False False False False 2 insufficient_or_context_specific +SERPINF2 -1.30837921479519 0.0086189442416555 0.257787006525209 -1.31515019653734 0.0082408980456892 0.287862310479138 0.524503163390933 1.0 -1.20600575675416 0.0095657345050797 0.797010319358304 0.0445965212029279 -0.408995437395859 0.286319702684933 reversed False True False False False False False 2 insufficient_or_context_specific +SPDYE3 1.28323153922619 0.0086878582630873 0.25838424659627 1.3554199953923 0.0055941765046668 0.265300960238175 0.0210329573184913 1.0 True True False False False False False 2 insufficient_or_context_specific +CAPN12 -2.0550412761266 0.0088055304199939 0.258484471839641 -2.30028051117238 0.0023241515153975 0.223491901031981 0.355366609278415 1.0 False True False False False False False 2 insufficient_or_context_specific +NOP14 -0.859768453055896 0.0088331507929335 0.258484471839641 -0.767526987119247 0.023627577372592 0.348898908348731 -0.146731120141283 0.727896996957483 -0.220148248928286 0.489670914448412 -0.366879369069569 0.28669305445868 partial_or_other False True False False False False False 2 insufficient_or_context_specific +GSE1 -0.903952249910695 0.0088423892215937 0.258484471839641 -1.14646115193286 0.000330737990637 0.148975599106358 0.407930571386276 1.0 -0.396870125131186 0.125199643941761 0.279940698787318 0.205240723211765 -0.116929426343868 0.639697984928692 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SLC44A5 -1.61930846581104 0.0089033448441099 0.258484471839641 -1.61568977732807 0.0090605639192159 0.294972133399338 False True False False False False False 2 insufficient_or_context_specific +KHDC4 0.468496774179987 0.0089848420884058 0.258484471839641 0.474623374056373 0.0079313603520453 0.287862310479138 0.0819983412450883 0.099828519370145 2.0 -0.20473954579673 0.44312095765373 -0.440368132054602 0.0624461886446697 -0.645107677851332 0.0190626030269611 partial_or_other True True False False False False False 2 cross_species_direction_conflict +AC087741.1 -1.02421393230361 0.0090233621143827 0.258484471839641 -1.09152608159528 0.0047699774570292 0.261521011602645 False True False False False False False 2 insufficient_or_context_specific +RPL29 0.797793059737776 0.0090345808585885 0.258484471839641 0.786304507370259 0.0103070783064878 0.302245517751671 1.36575915789222 0.670974493207495 0.0146992409013025 3.0 True True False False False False False 2 insufficient_or_context_specific +NR1H3 -0.744774780877434 0.0090375536424402 0.258484471839641 -0.711119414500483 0.0133757569981982 0.313114831651016 0.436878858697301 1.0 -0.203457762481866 0.48819689511927 0.423818211827062 0.0852962326150015 0.220360449345196 0.38614815699848 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SRSF7 0.589586747175182 0.009163867281016 0.259558601898396 0.480202862311066 0.0432610757170184 0.391724217341578 0.566617673306542 0.111076163669562 0.128826048358332 3.0 -0.0170899214277139 0.95762493377024 -0.896345119106684 0.003200423424525 -0.913435040534398 0.0041720247456539 partial_or_other True True False False False False False 2 cross_species_direction_conflict +PHRF1 -0.679945690489003 0.009203850261052 0.259558601898396 -0.568930773436341 0.0361004408003533 0.37720666979567 -0.0270853893658666 0.94096962322409 -0.460235756795031 0.0721530524052892 -0.487321146160897 0.0749664493929411 partial_or_other False True False False False False False 2 insufficient_or_context_specific +DNM3 0.976109925787171 0.0092190259245973 0.259558601898396 0.990644813433647 0.0081931656584241 0.287862310479138 0.164068289062206 0.0865384581439711 2.0 True True False False False False False 2 insufficient_or_context_specific +AMIGO2 -1.01599331532118 0.0092636924951909 0.259601690244713 -1.00922375990602 0.0099136599063551 0.301624803148371 0.273778188395277 0.713982722330838 2.0 0.155274870338143 0.859978669248598 0.622887240892713 0.236555931024969 0.778162111230856 0.208684355204444 partial_or_other False True False False False False False 2 insufficient_or_context_specific +MRVI1 1.13718048730868 0.009469158710485 0.261715648338485 0.30942266649773 0.527137265841108 0.804819865166353 1.42940772220176 0.165670147338522 2.0 1.41877306393147 0.0006900180120358 -0.908778130702904 0.0057597151382826 0.509994933228563 0.0887810971320758 reversed True False False False True False True 2 residual_state_candidate +STAU1 -0.482878551229901 0.0095611842937952 0.263321028459492 -0.452317475233694 0.0160055046860989 0.322306608081226 0.606841938559202 1.0 -0.0065091506748307 0.982820732401142 0.173518590164993 0.399183405604824 0.167009439490163 0.448141635453421 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SPG7 -0.628161082053384 0.0097548004900819 0.266816537757216 -0.613804160759111 0.0119187750061402 0.306601496403255 0.382186509690849 0.118764265104191 -0.259306840195014 0.222583639106703 0.122879669495835 0.604474096547143 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SCN11A -1.4098698608194 0.0098921250212405 0.2687001007293 -1.17407043353312 0.0354385653046757 0.37720666979567 False True False False False False False 2 insufficient_or_context_specific +TCOF1 -0.925596748111209 0.0099637632771307 0.2687001007293 -0.768298315858524 0.0413060482504403 0.389383265560847 0.0360593220616945 0.93306395305472 -0.244085834444544 0.384971445107528 -0.208026512382849 0.504178444966875 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ACOT7 -0.98344609451313 0.0099776475293022 0.2687001007293 -1.01355379627744 0.0077196660837833 0.287862310479138 0.153819954014413 0.580749809049578 -0.239919194275822 0.274273996479588 -0.086099240261409 0.739564849239821 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ATP5F1C 0.530817286114369 0.0100185890053002 0.2687001007293 0.513670944848247 0.0133588281343214 0.313114831651016 1.51039654029675 0.0703504420791822 2.0 True True False False False False False 2 insufficient_or_context_specific +GRM8 -1.18087769986551 0.0100781882703873 0.26906691761025 -0.965360813601338 0.0393693731012205 0.379484931484566 False True False False False False False 2 insufficient_or_context_specific +EXOC7 -0.678238591782987 0.0101127528045087 0.26906691761025 -0.693649045863565 0.0082834581518012 0.287862310479138 -0.178103191737642 0.583119171304424 -0.0187291348340371 0.950559403060548 -0.196832326571679 0.481412627819409 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FP671120.1 -1.20980307114851 0.0102339949587374 0.269890529140342 -1.19205857188945 0.0117344516052351 0.305645553145081 False True False False False False False 2 insufficient_or_context_specific +LINC00106 -0.74735393531813 0.0102551540744957 0.269890529140342 -0.864817500222642 0.0024857693011853 0.224500148429329 False True False False False False False 2 insufficient_or_context_specific +AF117829.1 0.49343058926656 0.0102995489240084 0.269890529140342 0.578768704711334 0.0019276395494212 0.223491901031981 0.112690160351901 1.0 True True False False False False False 2 insufficient_or_context_specific +KNDC1 -1.30569766145318 0.010319140360947 0.269890529140342 -1.38102393656267 0.0056752734729593 0.265907216454356 False True False False False False False 2 insufficient_or_context_specific +DENND3 1.07451629100581 0.0103273132953872 0.269890529140342 0.977978363753845 0.0207544358866709 0.333389311130767 0.0435766027176156 1.0 -0.328318050497062 0.385997921208567 -0.674119317744187 0.0521143177243751 -1.00243736824125 0.0158012804720531 partial_or_other True True False False False False False 2 cross_species_direction_conflict +AL627171.2 -0.938921028008492 0.0103699596369012 0.269958933674839 -0.872278255598633 0.0188862890703015 0.330134834444111 False True False False False False False 2 insufficient_or_context_specific +SUPT20H 0.412553559253885 0.0105459754929587 0.273573487112182 0.460455202262774 0.0037265080911584 0.243764662040058 0.0634710738109004 1.0 True True False False False False False 2 insufficient_or_context_specific +CHRD -1.22007357691776 0.0107676022502366 0.274073458004984 -0.93825807772004 0.0572439285173121 0.424455207563489 0.47349715633595 1.0 -1.62681472103822 0.000829621270509 -0.106007932357687 0.778847583482528 -1.73282265339591 0.0017468801289819 persistent False False False False False True False 2 insufficient_or_context_specific +AFMID -1.05681960978457 0.0107785249248712 0.274073458004984 -1.07239046106963 0.0095775152975851 0.298763048903795 -0.794834926882122 0.0667885641616118 0.769207942821949 0.0521191490653261 -0.0256269840601729 0.954985300470877 reversed False True False False False False False 2 insufficient_or_context_specific +AC139491.7 2.44543030733755 0.010817921546852 0.274073458004984 1.86411203904351 0.0464909267045876 0.398741839274603 0.147439899127817 1.0 True True False False False False False 2 insufficient_or_context_specific +KCNIP2 -1.1561528624211 0.0108328392111623 0.274073458004984 -1.05261638812743 0.0226875778474616 0.346028040476539 False True False False False False False 2 insufficient_or_context_specific +SYNM -0.87074746843327 0.0108507961210535 0.274073458004984 -0.979146005400194 0.0030459170421999 0.228908329282484 -0.649643547792887 0.328784942023977 0.905707075738373 0.0900102488692148 0.256063527945486 0.669236271831733 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RARA -0.763377232309655 0.0108933934381818 0.274106475701954 -0.707476361623927 0.0203487467865138 0.332725011651872 0.434126772405473 0.5230176683210259 2.0 -0.467569773177726 0.0637784290788614 0.359951143498005 0.105113799844399 -0.107618629679721 0.659260069995645 partial_or_other False True False False False False False 2 insufficient_or_context_specific +HSD17B6 -1.31892334526541 0.0110019644485063 0.275911497974655 -1.57023861049464 0.0018747091196208 0.222395268370307 -0.150191963671236 0.873312189626408 1.24780998549337 0.0653276421182545 1.09761802182213 0.114681685105138 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ANKDD1A 0.819331305177064 0.0111723751105669 0.278513274565188 0.756902613533113 0.0196051866030676 0.330467462546779 0.6281073996692671 0.0401317717026893 2.0 True True False False False False False 2 insufficient_or_context_specific +AC091563.1 1.4951108062332 0.0112078499738986 0.278513274565188 1.32658753045418 0.0260017919176092 0.353316498154592 0.0455239645972192 1.0 True True False False False False False 2 insufficient_or_context_specific +FGFR3 -1.45554487777808 0.0112376070245094 0.278513274565188 -1.45240757895627 0.0115702808833967 0.303878173051996 -0.0141533867016348 0.966914103119093 -0.287623933381346 0.214222312921171 -0.301777320082981 0.22428246877682 partial_or_other False True False False False False False 2 insufficient_or_context_specific +DOPEY1 0.402714833465993 0.0113693722320106 0.280178926878211 0.361133826699315 0.0238574048833525 0.348898908348731 True True False False False False False 2 insufficient_or_context_specific +C16ORF70 -0.737981428486188 0.0113888758629459 0.280178926878211 -0.760731130295654 0.0086021689775655 0.291509786412688 0.48340089213138 1.0 False True False False False False False 2 insufficient_or_context_specific +RXRA -0.919176029122849 0.0113906361482608 0.280178926878211 -1.00478344933047 0.0044868889155876 0.261521011602645 0.816959884371967 2.35353353066849 2.0 -0.598614964623529 0.0555172149057016 0.881263347637291 0.0078712899751426 0.282648383013762 0.314535004750728 reversed False True False False False False False 2 insufficient_or_context_specific +CAMKK2 -0.453528485751931 0.0115264224826515 0.280851197393928 -0.50718543686044 0.0037296941126294 0.243764662040058 -0.108916702039107 0.690404920343846 -0.164223441177043 0.436933438497611 -0.27314014321615 0.226041628690408 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC027808.1 0.759521291946536 0.0115817405591516 0.280851197393928 0.768843697176979 0.0106831002445979 0.302391883062908 0.0444934961177969 1.0 True True False False False False False 2 insufficient_or_context_specific +FP236383.1 -1.37185218700481 0.0116773554117044 0.280851197393928 -1.44018239405279 0.0073789788553167 0.287862310479138 False True False False False False False 2 insufficient_or_context_specific +SLC35G2 0.801871150309368 0.0116891942977616 0.280851197393928 0.856702452315412 0.0070151081090228 0.282692791660547 0.564755163448895 0.8788805669190259 2.0 True True False False False False False 2 insufficient_or_context_specific +LEPR 0.95402164149033 0.0117478916605484 0.280851197393928 1.06704781388778 0.0043345912113942 0.260026215965344 True True False False False False False 2 insufficient_or_context_specific +TM2D3 0.742703965510922 0.0117914283258073 0.280851197393928 0.601905006799197 0.0418931546924862 0.3908928278867 0.0359859508070361 1.0 -0.270256431163114 0.454792599345931 0.126510095760153 0.687321422272142 -0.143746335402961 0.672367270763274 partial_or_other True True False False False False False 2 cross_species_direction_conflict +GCLC -0.687585867900642 0.0120798101450827 0.285321332241125 -0.576430052346602 0.0354893537012439 0.37720666979567 0.323638879323219 1.0 0.520792600879358 0.339736275985354 -0.354545961643257 0.452263446896508 0.166246639236101 0.760710459018827 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RPS6KA2 1.07344913072575 0.0122512406810711 0.28744133135722 0.930501421777975 0.0304793166506205 0.374622380904833 2.90965511233436 0.424383033776531 0.283361260740228 3.0 True True False False False False False 2 insufficient_or_context_specific +TMEM175 -0.836584713052302 0.0124014087902106 0.287770113018094 -0.845444957723549 0.0111698709935317 0.302570357129259 0.0537567040124514 0.914827918728458 0.0950990652842539 0.776068078667674 0.148855769296705 0.694212395639852 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PCNX2 1.47940362882947 0.0124093900244092 0.287770113018094 1.32792167001571 0.0250572096971203 0.351006805738558 0.224163886406653 0.14222636327541 2.0 True True False False False False False 2 insufficient_or_context_specific +PALLD 1.15144792700645 0.0124198197821319 0.287770113018094 0.0509025609125346 0.923649336815252 0.978025243014285 0.191729588957619 1.58434968374922 0.149790470109972 0.123175984909449 4.0 0.617604480200832 0.159351274500249 0.0303952775271019 0.944495819018988 0.647999757727934 0.11498304662238 partial_or_other True False False True False False True 2 insufficient_or_context_specific +PLOD1 -0.640658176684386 0.0124948300760117 0.288661754680313 -0.721089038432842 0.0038967349611745 0.246357651018449 0.254871205894482 0.389969516918662 -0.449058243076923 0.082451022271885 -0.194187037182441 0.475889131228915 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ARFGAP1 -0.805849596383211 0.0127146031868232 0.29096528436151 -0.73343811717228 0.0260573976517711 0.353364513330128 -0.203447394343779 0.574518471018978 -0.498360626790204 0.098929251676969 -0.701808021133983 0.0369500794020714 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TECPR1 -0.695051520829085 0.0128329409193709 0.29096528436151 -0.72611699007817 0.0087352358995693 0.291509786412688 -0.157289325867417 0.649290563012388 -0.146582710170318 0.598999684307684 -0.303872036037735 0.291205070824373 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FAM13A 0.921443991072437 0.0128594866173704 0.29096528436151 0.801513303274157 0.0334846684530637 0.376280667109215 0.4342630023734421 0.157543159295103 2.0 -0.496515722298779 0.149029449922273 0.420749656883441 0.153264899991127 -0.0757660654153376 0.82869638988022 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CYP2E1 -1.39622879555681 0.0128960252265942 0.29096528436151 -1.60556907824921 0.0036100678661001 0.243710520549117 -2.19667014979026 0.0090378914220066 2.87086038214253 0.0026222317247209 0.674190232352271 0.314470938578143 reversed False True False False False False False 2 insufficient_or_context_specific +NCS1 -1.33582053705752 0.0129271704504293 0.29096528436151 -1.33698454147032 0.012759393264889 0.313114831651016 0.210999192466857 0.637962343051058 0.11410472565514 0.736917661904505 0.325103918121997 0.382330014536178 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZNF529 0.688928176650441 0.0130390528149376 0.291447794709001 0.69102031210545 0.012968893740275 0.313114831651016 True True False False False False False 2 insufficient_or_context_specific +PLEKHA4 -0.750060789216312 0.013056905370085 0.291447794709001 -0.657753175136786 0.0295419693991123 0.371414855918995 0.6201692458393521 1.0 1.06851124520943 0.0513510304064572 -1.3780999052734 0.0105984858709472 -0.309588660063967 0.574210868033683 reversed False True False False False False False 2 insufficient_or_context_specific +CRK -0.579495469722946 0.0131188817417641 0.292213403859801 -0.632537963886117 0.0058253884494284 0.266412407248749 0.533391033741456 1.0 -0.191740620848526 0.517180233396694 -0.793311241639705 0.0082467231047042 -0.985051862488232 0.0046265177645903 partial_or_other False True False False False False False 2 insufficient_or_context_specific +EPDR1 0.722221991031392 0.013222407647879 0.292253024645663 0.626903400725858 0.0320023327228372 0.375031405408838 0.0688542672635504 0.311455966701819 0.0218425610539745 3.0 -0.384679484637878 0.743110500122104 0.456197183751941 0.56876891128323 0.0715176991140623 0.944782606937068 partial_or_other True True False False False False False 2 cross_species_direction_conflict +FGFR1OP2 0.589183366584358 0.0134961860808424 0.292253024645663 0.501966567111733 0.041593109654976 0.390826995201837 0.0907374335809447 0.101730909485746 2.0 -0.126082490892836 0.687967980648355 -0.2558233002613 0.295971405845547 -0.381905791154137 0.142400211824267 partial_or_other True True False False False False False 2 cross_species_direction_conflict +MVB12A -0.577439978502315 0.0135484059973201 0.292253024645663 -0.551543271927205 0.019219203143868 0.330467462546779 0.6184376085850961 1.0 -0.0009402622093399 0.997814636845362 0.360022277230061 0.154193513429958 0.359082015020721 0.187599784714189 partial_or_other False True False False False False False 2 insufficient_or_context_specific +NUTF2 -0.733101818106318 0.0136027577063481 0.292253024645663 -0.774673147467058 0.0081405686935644 0.287862310479138 -0.205391306259179 0.794014640316981 -1.2280137233054 0.0583263592689521 -1.43340502956458 0.0504747545196111 partial_or_other False True False False False False False 2 insufficient_or_context_specific +DDX46 -0.398349442338207 0.0136189134424764 0.292253024645663 -0.473334032132195 0.0020170107434546 0.223491901031981 0.0339267384731914 0.917945009132389 -0.544535719374795 0.02663765572838 -0.510608980901604 0.0424409426259765 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TPRN -0.986683032288591 0.0136777261035058 0.292919740772443 -0.904142798833233 0.0268464048772804 0.356222495883986 -0.963434603193571 0.237880289162034 0.0376901488159303 0.964307556569782 -0.92574445437764 0.216694400051608 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZNF586 -0.396759174792083 0.0137879389325368 0.294086988383279 -0.412045971518393 0.0098502252821441 0.301445445011239 False True False False False False False 2 insufficient_or_context_specific +MAMDC2 1.55270068324114 0.0139671381338065 0.294366420705352 0.914495610763708 0.15041861261094 0.533583468169136 0.333987103801017 0.460657477197945 0.274780089138344 3.0 0.552586360412473 0.191346521738403 0.751096745931686 0.0440208676074531 1.30368310634416 0.0075508193403489 partial_or_other True False False False True False True 2 residual_state_candidate +BRD9 -0.641447486102724 0.0140065248709529 0.294366420705352 -0.640651853554245 0.0141174439450454 0.315120450680315 0.243171760036625 0.456570575749014 -0.613313524423841 0.0369902402609031 -0.370141764387216 0.204780707112956 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TRPC3 -1.86591190944614 0.0140398806631756 0.294366420705352 -1.90905188708354 0.0115342908881102 0.303878173051996 False True False False False False False 2 insufficient_or_context_specific +CEP170B -1.1578767991914 0.014064078120908 0.294366420705352 -1.12176403203581 0.01814741914226 0.32629129734252 0.116566339624816 0.715407116185129 -0.372077580801493 0.132722911622444 -0.255511241176677 0.330077056748354 partial_or_other False True False False False False False 2 insufficient_or_context_specific +B3GALNT2 0.674138980468934 0.0140954359154611 0.294366420705352 0.668022689989487 0.0153203239141685 0.320853404849916 0.380731541897314 0.0744990014613494 2.0 -0.0506345350140852 0.873026380943741 -0.425636043350582 0.0639999214513155 -0.476270578364667 0.0556752012051446 partial_or_other True True False False False False False 2 cross_species_direction_conflict +EDARADD -0.938261944232266 0.0141077295772786 0.294366420705352 -0.93908297548986 0.014001949514469 0.314756631908661 False True False False False False False 2 insufficient_or_context_specific +MTERF1 0.536943890706329 0.0142293163225751 0.295153480812865 0.551361181446213 0.0114650572296843 0.303576144732418 0.0676311135327457 1.0 True True False False False False False 2 insufficient_or_context_specific +CUL9 -0.605142360551296 0.0143276557259104 0.295989240927797 -0.498903306659465 0.0488699337046396 0.404047580308211 0.356568379289606 0.677125177648188 0.0622647450504876 0.924451901685116 0.418833124340094 0.563870018052455 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CLK2 -0.768261987061089 0.0144321163768943 0.296448024722276 -0.747328065574985 0.0179322963467953 0.32629129734252 0.103638327735344 0.72761752306391 -0.188259830173894 0.406484535852064 -0.0846215024385506 0.748176184886603 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FAM160B1 0.388849435001958 0.0146973597723032 0.297043416491418 0.331724096664755 0.0404583389855681 0.385175061325183 0.257277642663452 0.0420065856270899 2.0 -0.448347699618944 0.159342691534864 0.198745836989926 0.482310194558869 -0.249601862629018 0.396809900615665 partial_or_other True True False False False False False 2 cross_species_direction_conflict +DIAPH2-AS1 1.20224008675926 0.0147923915022593 0.297043416491418 1.05327489607998 0.0337659178627462 0.376543096535729 0.0511788932601245 1.0 True True False False False False False 2 insufficient_or_context_specific +FAM19A5 1.19913309250107 0.0148234454982531 0.297043416491418 1.12324114316311 0.0229091342365007 0.346028040476539 0.0919107511923261 1.0 True True False False False False False 2 insufficient_or_context_specific +TEP1 -0.418194663168042 0.0148417608996409 0.297043416491418 -0.438263324368503 0.0099726873601857 0.301624803148371 0.136366411108065 0.65674314972199 -0.320628047135869 0.176822971789829 -0.184261636027805 0.479481988453045 partial_or_other False True False False False False False 2 insufficient_or_context_specific +HFM1 1.01847160156821 0.0148867592346196 0.297043416491418 0.900672027640239 0.0322135302903101 0.375031405408838 0.0519227657529141 1.0 True True False False False False False 2 insufficient_or_context_specific +FTX 0.48529868105953 0.0149067589196511 0.297043416491418 0.514746871438017 0.0089295928170374 0.291884337344524 0.201133270949464 0.227522547235215 2.0 True True False False False False False 2 insufficient_or_context_specific +MARCH6 0.407804201453422 0.0149801508605103 0.297043416491418 0.456899563273149 0.005628769807972 0.265306034073968 0.10128912921979 0.0868382111862868 2.0 -0.388632688205213 0.101766799536154 0.132464548493797 0.532521273061934 -0.256168139711416 0.239814743755085 partial_or_other True True False False False False False 2 cross_species_direction_conflict +BANP -0.712777517038639 0.0150202081179672 0.297043416491418 -0.717870200019472 0.0142863376285462 0.316089554819539 0.308554527855872 1.0 0.479164080588088 0.218250507709268 -0.914303875735269 0.0169307228026709 -0.435139795147182 0.243657850784534 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TAF8 -0.466755038682477 0.0151180275427549 0.297043416491418 -0.3985611710931 0.0421174395274359 0.3908928278867 0.8191098613520721 0.3862196110477971 2.0 -0.44474646443425 0.108510320725145 -0.32471010116678 0.185710708865736 -0.769456565601029 0.0131086841178374 partial_or_other False True False False False False False 2 insufficient_or_context_specific +KCND2 2.70837824157995 0.0151456127665399 0.297043416491418 3.13241717795081 0.0055309489115715 0.265300960238175 1.07505114361601 0.655833160311525 0.480978212956885 3.0 True True False False False False False 2 insufficient_or_context_specific +DDX56 -0.689532477363976 0.0151736377957656 0.297043416491418 -0.642918961195735 0.0246489996414217 0.349408136686844 -0.005387705573486 0.988138064151707 -0.336468196129569 0.151093694933679 -0.341855901703055 0.172343938336757 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ARFGAP2 -0.766646170112272 0.0151903220936928 0.297043416491418 -0.774021776685726 0.0140424221598048 0.314776843234011 0.06503719353797299 0.656718914034228 2.0 0.0325366264264003 0.939953142486704 -0.278299152625531 0.338962619539012 -0.24576252619913 0.424098343255221 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CPSF4 -0.710894107866392 0.0152403017308489 0.297043416491418 -0.664703837114561 0.0244385791900141 0.349408136686844 -0.397279312360791 0.102155541429174 -0.206156399026328 0.331603223030082 -0.603435711387119 0.0201349712657595 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TASP1 0.627278099794747 0.0152968352630611 0.297043416491418 0.700774444268431 0.0055233916469347 0.265300960238175 1.49372155817458 0.136803992856665 0.144747003517323 3.0 -0.444677684816784 0.268640494859393 -0.270949886575844 0.439538862002694 -0.715627571392628 0.0670324052500536 partial_or_other True True False False False False False 2 cross_species_direction_conflict +SLC2A4RG -1.18059169608165 0.01536087001622 0.297043416491418 -1.02250237913141 0.0390368173547203 0.379484931484566 0.242128882812658 1.0 False True False False False False False 2 insufficient_or_context_specific +SBNO2 -0.777671081526389 0.0153898628563908 0.297043416491418 -0.87602111905894 0.0052066466234412 0.265121723850427 0.622498203991516 0.548273910730279 2.0 -0.408445134551447 0.303412244260649 -0.781917308444166 0.0389870773095688 -1.19036244299561 0.0093945529505454 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZBTB7A -0.633354168431092 0.015580101760524 0.298027091192993 -0.631862056691533 0.0158602355234444 0.320853404849916 0.51605554273132 1.0 0.0467656019251181 0.8801648634959 -0.0148573276627963 0.952179584858255 0.0319082742623218 0.904988058389608 partial_or_other False True False False False False False 2 insufficient_or_context_specific +C19ORF66 -0.894918231652761 0.0156090740218539 0.298027091192993 -0.756323673934973 0.045643021531848 0.396366573573853 False True False False False False False 2 insufficient_or_context_specific +CDA -1.82036061052244 0.0156663227516681 0.298027091192993 -1.77363321427191 0.0192912792479737 0.330467462546779 -0.638521929435595 0.444978159545076 0.314556403674545 0.647392572739189 -0.32396552576105 0.672130434360972 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PHF8 -0.438240691340261 0.0157682143241001 0.298352700419085 -0.460640084914724 0.0103955190108715 0.302245517751671 0.0098905479938058 0.981791385427173 0.0901620530584305 0.772120929715521 0.100052601052236 0.77143252266152 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SHC2 -0.972877596480761 0.0159812256434385 0.299692671530782 -0.960500659095981 0.017607875234093 0.326204572615871 False True False False False False False 2 insufficient_or_context_specific +A1BG -0.704331295107027 0.0162229853234254 0.299692671530782 -0.605941880754774 0.0404107485388546 0.385111171075935 False True False False False False False 2 insufficient_or_context_specific +PIK3CA 0.650368259832859 0.0162636774978832 0.299692671530782 0.367316959973552 0.195951998221039 0.571700325195908 1.3428112457663 1.02905819824227 0.0685988866496729 0.0763714650920179 4.0 0.0934444194298993 0.743421317382967 0.227255872484126 0.28005423244375 0.320700291914025 0.158810549884311 partial_or_other True False False True False False True 2 insufficient_or_context_specific +QRICH1 -0.440639145119001 0.0163708990436437 0.299692671530782 -0.489690960428101 0.005934496859799 0.266950960575468 0.11128792541155 0.676859385397925 -0.242658852426145 0.23740734860177 -0.131370927014595 0.564947155804403 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AL354822.1 1.08262676650619 0.016440538156949 0.299692671530782 0.953717814580303 0.0367884907162839 0.378570063335794 0.0397711552705532 1.0 True True False False False False False 2 insufficient_or_context_specific +MGLL -0.639846901301866 0.0164451232551821 0.299692671530782 -0.688312765725574 0.0092198675042723 0.296778539969839 0.909024519623802 1.0 -1.02179063254847 0.003091207359983 0.811799046709951 0.0083726604961003 -0.20999158583852 0.425895928621757 reversed False True False False False False False 2 insufficient_or_context_specific +SURF6 -0.744035685672479 0.0164605900948156 0.299692671530782 -0.747020679766414 0.0158486464193719 0.320853404849916 0.9077568593944209 1.0 -0.14307171347697 0.683962937348882 -0.242730955580105 0.362568393658862 -0.385802669057075 0.185894100797154 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FAM213A -0.667049841438932 0.0165551555063461 0.299692671530782 -0.564450581278219 0.0474272266874629 0.401231297569097 False True False False False False False 2 insufficient_or_context_specific +AC012404.1 1.19381327907006 0.0166659450725028 0.299692671530782 1.19839070412557 0.0165802850332209 0.325489753822016 0.0509819517485377 1.0 True True False False False False False 2 insufficient_or_context_specific +CDK5RAP3 -0.700801706536285 0.0166760597550237 0.299692671530782 -0.588852877732653 0.0478134672715911 0.401952804329389 0.531150157389592 0.68660215561536 2.0 -0.228294222052601 0.377249360011217 -0.295382380342624 0.185568564063125 -0.523676602395225 0.0378001016925948 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SREBF1 -0.821414236433621 0.016695817302521 0.299692671530782 -0.891711587060416 0.0083266180628758 0.288237486910963 0.88397499507218 0.364016218217353 2.0 -0.4272501316266 0.290074575005487 0.283910975242487 0.414520184003729 -0.143339156384113 0.717216565922444 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RBM20 1.47917712793617 0.016696565547505 0.299692671530782 1.43478835697453 0.0205715489737961 0.333389311130767 0.04677339195723 1.0 True True False False False False False 2 insufficient_or_context_specific +GAK -0.732763443840975 0.0167269735346327 0.299692671530782 -0.801190320114284 0.0075575761699157 0.287862310479138 -0.10018156906736 0.741563261282446 0.0407416820408653 0.875961867724892 -0.0594398870264942 0.82694027862204 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC106895.2 1.06536940852046 0.0167370023731701 0.299692671530782 0.967541631670734 0.0293995284489525 0.370848532095628 0.0305361298229992 1.0 True True False False False False False 2 insufficient_or_context_specific +ILF3 -0.715116052070986 0.0167916132171875 0.299692671530782 -0.633505350796454 0.0380008241625635 0.379484931484566 0.257388290505096 0.54924512230233 2.0 0.323395334830613 0.191501364421012 -0.633677470058384 0.011607751173525 -0.310282135227771 0.185247534244091 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC068234.1 -1.25557488604277 0.0168517262149038 0.299692671530782 -1.26172369637919 0.0163902047230673 0.325244142514861 False True False False False False False 2 insufficient_or_context_specific +FBXL3 0.555073809690808 0.016890464697011 0.299692671530782 0.440407190779029 0.056260879031379 0.423380157386529 0.103516368954725 1.0 0.25076325659665 0.591181334472644 0.464270765143399 0.179709475217335 0.715034021740049 0.0755975306593175 partial_or_other True False False False True False True 2 residual_state_candidate +PRKAA2 1.31355806613617 0.0169176768547401 0.299692671530782 0.963160764200844 0.0824034497227451 0.462431570888118 0.0453806373021294 1.0 0.165064406458507 0.583798954286931 0.575294658484744 0.0248096853167256 0.740359064943251 0.0138105850453239 partial_or_other True False False False True False True 2 residual_state_candidate +F2 -1.21091577943197 0.0170016269331169 0.300675338626211 -1.23281145743457 0.0148694332391353 0.319088366135753 0.5271099322629039 1.0 -1.17399704894987 0.0342855119560069 1.12578732302325 0.0305815284846226 -0.0482097259266202 0.932661736100554 reversed False True False False False False False 2 insufficient_or_context_specific +MAP3K14 -0.535895458358047 0.0171036733519638 0.301435024243716 -0.555402204640623 0.0128837730901439 0.313114831651016 0.593809593676922 0.564732199097064 2.0 -0.223815583137855 0.514723341628365 -0.179730090074353 0.52507830435609 -0.403545673212208 0.179106368613445 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PHGDH -0.912295285209356 0.0171302343764188 0.301435024243716 -1.10729421734896 0.0025507200798886 0.224500148429329 False True False False False False False 2 insufficient_or_context_specific +PSAT1 -1.22773026217807 0.0171981136227446 0.301624059184282 -1.26875796092888 0.0133278543548795 0.313114831651016 False True False False False False False 2 insufficient_or_context_specific +HECW1 1.44263246199403 0.0174544557280826 0.304601890210076 1.97001802718977 0.0011662202716993 0.187272944881803 0.702997695805256 0.112514638173243 2.0 True True False False False False False 2 insufficient_or_context_specific +RNF217-AS1 0.857772051281415 0.0175586148369188 0.304839080101775 1.09556624416607 0.0018543954811736 0.222395268370307 0.0726814980357281 1.0 True True False False False False False 2 insufficient_or_context_specific +LDLR -1.20661131673113 0.0175835385283179 0.304839080101775 -1.47148659587378 0.003654429821581 0.243764662040058 -0.630258527515158 0.0204318510871367 0.397268144177581 0.0875308787169787 -0.232990383337577 0.322993539741369 reversed False True False False False False False 2 insufficient_or_context_specific +ZNF519 0.67234789553462 0.0176619803092506 0.304940639395205 0.612078356016775 0.0320646348974309 0.375031405408838 0.0544596551060568 1.0 True True False False False False False 2 insufficient_or_context_specific +RPS15 0.865418479621017 0.0176760438823513 0.304940639395205 1.30000789534394 0.0002825183043373 0.142039440818736 0.6807656829970239 0.0333821115492759 2.0 True True False False False False False 2 insufficient_or_context_specific +AC010636.2 0.976507827534608 0.0180017481107775 0.307150938068899 0.866860835121991 0.0357854381850793 0.37720666979567 0.0246127980351266 1.0 True True False False False False False 2 insufficient_or_context_specific +NAA40 -0.990821795211876 0.0180249858412667 0.307150938068899 -1.01923386357814 0.0146398876658696 0.317541556275699 0.237136896639961 0.488522479960615 -0.586041480624679 0.046599364197446 -0.348904583984719 0.255683205953856 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CHST9 1.32982766078828 0.0180505996850967 0.307150938068899 1.42232583044965 0.0119230512500651 0.306601496403255 0.891066023800063 1.0 True True False False False False False 2 insufficient_or_context_specific +AC011092.2 1.02092710662011 0.0180659909585893 0.307150938068899 1.22285939675179 0.0044751257025548 0.261521011602645 0.042368714294772 1.0 True True False False False False False 2 insufficient_or_context_specific +UPB1 -1.32350921154429 0.0181136103665082 0.307465431269443 -1.43325759076719 0.0098058163557946 0.301445445011239 -0.819622985290325 0.0318406645351073 1.19128152525578 0.0045435402727912 0.371658539965453 0.266470793772336 reversed False True False False False False False 2 insufficient_or_context_specific +RNPEP -0.502234288968895 0.0181665167520305 0.307868513431682 -0.60285692325991 0.0030612278693522 0.228908329282484 0.44383709471515 1.0 0.064836296757256 0.848726472302442 0.0890574168147534 0.718638223241742 0.153893713572009 0.553924096889616 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PCNX1 0.355303285967706 0.0182173862366688 0.308143250330481 0.378913147240917 0.0110395177475599 0.302570357129259 True True False False False False False 2 insufficient_or_context_specific +F3 1.14687517919845 0.0183304846355015 0.308385251700923 0.815870174771329 0.0911780054191709 0.472234212482528 0.567179753296615 0.265979773863447 0.246249188108839 3.0 0.170057810192414 0.798361240228936 1.21641283877266 0.0107235498676064 1.38647064896508 0.013759890655975 partial_or_other True False False False True False True 2 residual_state_candidate +ASGR1 -1.56116095807377 0.0184032952891097 0.308385251700923 -1.62075141440746 0.0140117083725204 0.314756631908661 -0.920512188836735 0.0324726924163947 0.895734161173093 0.0273407528137498 -0.0247780276636417 0.955364787335465 reversed False True False False False False False 2 insufficient_or_context_specific +WWP2 -0.395947112677795 0.0184270674435823 0.308385251700923 -0.545051924458088 0.0002526416773564 0.136333247756677 0.507433287124238 1.0 -0.0967963256599197 0.850650382961004 -0.0615809950642516 0.876837486235366 -0.158377320724171 0.700269329176676 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZNF131 0.342019755210585 0.018509330935372 0.308385251700923 0.30571651532859 0.0359936120335844 0.37720666979567 0.081029345439898 0.0806821859639579 2.0 True True False False False False False 2 insufficient_or_context_specific +PSKH1 -0.523479686530116 0.0185475122968447 0.308385251700923 -0.529804670704089 0.016974321294439 0.326204572615871 0.0587139573623169 0.885130826731918 0.351550605730258 0.190492863094354 0.410264563092575 0.162148425910995 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PLEKHG2 -0.569379259016629 0.0187073886272372 0.309473467285879 -0.497334865164304 0.0443181713340517 0.393650849907072 0.285585204576928 1.0 0.617364714685241 0.0369044210144091 -0.436045756625488 0.0903781539099139 0.181318958059754 0.50413283499357 reversed False True False False False False False 2 insufficient_or_context_specific +IRF2BPL 0.956109332401872 0.0188900275875693 0.309690856008628 0.446018065379455 0.272105104911607 0.636016315620266 0.210323053229161 1.0 0.264399526907109 0.361077875409092 0.277927743353138 0.24346997836906 0.542327270260247 0.0488732546338837 partial_or_other True False False False True False True 2 residual_state_candidate +PROM1 -1.45738623530902 0.0190649471219952 0.311453903000669 -1.33118972052256 0.0340721085571185 0.376543096535729 False True False False False False False 2 insufficient_or_context_specific +IGHA1 1.74918348717473 0.0191670323997423 0.311453903000669 1.75369782615407 0.0191233201665258 0.330467462546779 0.0536547430440875 1.0 True True False False False False False 2 insufficient_or_context_specific +AL591845.1 1.10634346608693 0.0191673951270736 0.311453903000669 0.987569164871653 0.0376958665862684 0.379484931484566 0.0284008494256691 1.0 True True False False False False False 2 insufficient_or_context_specific +DHCR24 -0.96497768870479 0.0194074255731202 0.312583300557302 -0.997656015955427 0.0151994651079693 0.320500116612027 0.562341534384624 0.0988932747383366 -0.497135142514479 0.104627239630973 0.0652063918701441 0.856202437093372 reversed False True False False False False False 2 insufficient_or_context_specific +ZNF250 0.647175678587742 0.0194327606575669 0.312583300557302 0.726937000997253 0.0082432350217197 0.287862310479138 0.0256110866088097 1.0 True True False False False False False 2 insufficient_or_context_specific +ANKAR 0.427158398705783 0.0194513381763731 0.312583300557302 0.378212314806392 0.0387992703613139 0.379484931484566 0.0876719626569534 1.0 True True False False False False False 2 insufficient_or_context_specific +PC -0.929834071244934 0.0194817453177676 0.312596150554697 -0.969727662644044 0.0139754849917135 0.314756631908661 0.372995251825142 1.0 False True False False False False False 2 insufficient_or_context_specific +RPL15 0.86368948959562 0.0195275480784849 0.312855618532084 0.972634135789136 0.0081979155087862 0.287862310479138 True True False False False False False 2 insufficient_or_context_specific +ACACA -0.42559556387053 0.0196148205424012 0.313776799941556 -0.391080119633214 0.033156895117555 0.376280667109215 0.259709622093067 1.0 -0.217110683657535 0.482690384261948 0.253333036429422 0.322278415348674 0.0362223527718868 0.90981542837227 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AGFG2 -1.01700494713937 0.0197226535735037 0.313776799941556 -1.33926612421135 0.0009943732960905 0.186944419865129 0.314805671723224 1.0 -0.656187827576817 0.0593987618921148 0.624190061447925 0.0463441110569953 -0.0319977661288925 0.92923636652208 reversed False True False False False False False 2 insufficient_or_context_specific +SEPT9 -0.99687431248961 0.0198579955255474 0.313776799941556 -0.863205193531788 0.0489392193973795 0.404177169779245 0.075549683255021 1.0 -0.122473505080659 0.721511676888663 0.281260956697842 0.286019666700871 0.158787451617182 0.583240555054372 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RPS6KB2 -0.874957858426619 0.0198689315437357 0.313776799941556 -0.841518678396763 0.0260722632964738 0.353364513330128 0.437708750537025 1.0 False True False False False False False 2 insufficient_or_context_specific +RILPL1 -0.497484198571597 0.0198816605348724 0.313776799941556 -0.487223525525805 0.0227404919766909 0.346028040476539 0.161285055536988 0.648693532914733 -0.398442443287149 0.149854966089578 -0.237157387750161 0.428232454788778 partial_or_other False True False False False False False 2 insufficient_or_context_specific +STARD4 -0.814968851289959 0.0199613522364376 0.314086373937866 -0.920350303928865 0.0078789351636025 0.287862310479138 0.0597751805787056 0.8890677464436 0.305765410635337 0.291909653632951 0.365540591214042 0.240893944246268 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RPS18 0.768478225562165 0.0201525467686701 0.314117964424248 1.18264239037448 0.0002582558207173 0.136333247756677 0.0213540500729625 1.0 True True False False False False False 2 insufficient_or_context_specific +FOXK2 -0.618176763366652 0.020175514999332 0.314117964424248 -0.6026211431364 0.0239913437640821 0.348898908348731 0.5436026652811741 1.0 -0.139426814745187 0.68125765850255 0.0318828628222539 0.916505500820119 -0.107543951922933 0.720853108766921 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RCN3 -0.840928838837158 0.0201801468417668 0.314117964424248 -0.750510567566134 0.0419082472843128 0.3908928278867 0.3615024865212371 0.40597089877105 2.0 0.712036497571415 0.0321074762952066 -0.485755918607462 0.0920639377691513 0.226280578963953 0.448672285177523 reversed False True False False False False False 2 insufficient_or_context_specific +CCNL2 -0.744261233668362 0.0203604108626421 0.31548815108364 -0.69554040111769 0.0325472581747344 0.375031405408838 0.117685388424645 0.72761752306391 -0.821824760689275 0.0093129832499171 -0.70413937226463 0.0233142909546514 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SLCO2B1 -1.18721525449358 0.0204454786061162 0.315573355881533 -1.2445709256792 0.0143162941961285 0.316089554819539 -1.55913074025804 0.0012861466199177 1.7165187648629 0.0011023600906998 0.157388024604861 0.666043360827916 reversed False True False False False False False 2 insufficient_or_context_specific +SLC25A47 -1.13964113911402 0.0204743084655096 0.315573355881533 -1.04957407345594 0.0351153132784764 0.37720666979567 -0.706501474111039 0.397310268783078 1.36851125849269 0.0684320560657617 0.662009784381647 0.373443769003255 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AC244021.1 -1.09752224026662 0.0205551539905435 0.315867329165892 -1.21135686388508 0.0093984411060268 0.297984207800093 False True False False False False False 2 insufficient_or_context_specific +UPP1 -1.3622302304303 0.020786198668725 0.318520588598547 -1.22992279959295 0.0394081389289466 0.379484931484566 0.276804300694627 1.0 False True False False False False False 2 insufficient_or_context_specific +AL136531.2 0.659924857477714 0.0209401714256235 0.31919574035472 0.746586447647909 0.0087852344919432 0.291509786412688 0.0602646471959804 1.0 True True False False False False False 2 insufficient_or_context_specific +PCNT -0.531249061544185 0.0209814210841235 0.31919574035472 -0.514593634851699 0.0263354900913108 0.354273049744177 0.498482645064701 1.0 -0.171731164807617 0.533138911232709 -0.213761158763019 0.341582776399734 -0.385492323570636 0.111940546986109 partial_or_other False True False False False False False 2 insufficient_or_context_specific +C5ORF17 1.712450298891 0.0211172117151287 0.320338392655645 1.82164367979913 0.0144548670059321 0.317541556275699 0.136682962013343 1.0 True True False False False False False 2 insufficient_or_context_specific +RCAN2 0.808649505129442 0.0211821424696678 0.320862353220591 0.868869296377651 0.0122077800100427 0.309429533546452 1.28695027968217 0.493238760031245 0.22708471777293 3.0 True True False False False False False 2 insufficient_or_context_specific +CDK10 -0.865143448570559 0.0212776569897312 0.321386984975081 -0.842535816354943 0.0257150329524518 0.351427309358494 0.0618089465633868 0.862121950436023 -0.418985559279454 0.0973787424355556 -0.357176612716068 0.181678224446525 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PTCHD1-AS 1.47655152199832 0.0214069135864589 0.322416824031145 1.57338314129453 0.0143143176169273 0.316089554819539 True True False False False False False 2 insufficient_or_context_specific +NPIPB4 -0.693170989259744 0.0214624121968341 0.322792233581446 -0.747720232339597 0.012246303220858 0.309429533546452 False True False False False False False 2 insufficient_or_context_specific +GPT -1.2670104756184 0.0215391449852961 0.323485480447733 -1.27825812373988 0.0201557067980514 0.332725011651872 -0.35239655503686 0.410942514895895 0.448896178671271 0.219306562265899 0.0964996236344115 0.821650651175632 partial_or_other False True False False False False False 2 insufficient_or_context_specific +INF2 -0.67597500924373 0.0216474714780587 0.324650573672363 -0.628570263860559 0.0353766434247741 0.37720666979567 0.273832498259907 1.0 -0.18507369105118 0.601341712328105 -0.489893232445453 0.0947903428520654 -0.674966923496633 0.0388585562189389 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZNF512B -1.06191604586582 0.0217269460239056 0.32491939960396 -1.02389130292529 0.028058376610698 0.364899801570861 False True False False False False False 2 insufficient_or_context_specific +ASGR2 -0.675592944185843 0.0220196535236345 0.325508705713526 -0.608498527149521 0.0434746860018578 0.392214551124798 -1.43017272847046 0.008433336846783 1.48773194942033 0.005892972358727 0.0575592209498776 0.911503240681756 reversed False True False False False False False 2 insufficient_or_context_specific +TMEM59 0.555214744500732 0.0220771202813247 0.325508705713526 0.560541718498565 0.0208092021249456 0.333389311130767 0.0766788152683856 1.0 -0.206390383951835 0.564734458670377 0.65879172591994 0.0363914833762319 0.452401341968105 0.14094529895172 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CLTB -0.721781146223774 0.0221894884329692 0.325508705713526 -0.859404433645455 0.0038095443489874 0.243764662040058 -0.570600026652547 0.159402358847057 0.549568645733271 0.128117765151398 -0.0210313809192755 0.962086618343326 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TNKS1BP1 -0.444382905147642 0.0222816228681304 0.325508705713526 -0.527665763175824 0.0047443865508436 0.261521011602645 0.3235788692359881 1.0 -0.0899413831010827 0.814087629826335 -0.61366964374694 0.0411675694420889 -0.703611026848023 0.0298248636211815 partial_or_other False True False False False False False 2 insufficient_or_context_specific +NR0B2 -1.86671338816819 0.0222970645629074 0.325508705713526 -1.97204808594897 0.0147551349588636 0.318578149070925 -1.52774011978819 0.031842265577242 1.29879128134197 0.0428254457157293 -0.228948838446219 0.726096419429722 reversed False True False False False False False 2 insufficient_or_context_specific +AC113383.1 1.6802492960802 0.0223172649900695 0.325508705713526 2.1955217738157 0.0037935176543956 0.243764662040058 0.084124359032392 1.0 True True False False False False False 2 insufficient_or_context_specific +NUP58 0.416836051359197 0.0224317830104581 0.325508705713526 0.378468624351348 0.0404151522591528 0.385111171075935 True True False False False False False 2 insufficient_or_context_specific +TICAM1 -0.759766436305347 0.0225503963478166 0.325508705713526 -0.706550599152486 0.035251699107147 0.37720666979567 0.551327107485991 1.0 -0.342725462284675 0.482628211514693 -0.0920193629011069 0.83436555332437 -0.434744825185781 0.310559571769645 partial_or_other False True False False False False False 2 insufficient_or_context_specific +MVD -1.01242533253692 0.0225669096447568 0.325508705713526 -1.22877367513171 0.0029436001914879 0.226850589939629 0.486176349764261 0.506924940457442 -0.649219411566013 0.247858451135441 -0.163043061801752 0.827987608084063 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PLXNB1 -1.10207461697932 0.0225943502233899 0.325508705713526 -1.05307900713878 0.030620472286366 0.375031405408838 -0.436476995010353 0.126760918126025 -0.210380215019465 0.40601973924532 -0.646857210029819 0.0279405435141411 partial_or_other False True False False False False False 2 insufficient_or_context_specific +AHNAK -0.645633785430927 0.02269049097253 0.325660651931415 -0.581269466559892 0.0446972608544669 0.393650849907072 -0.147200411817498 0.727190108818436 -0.26360082078601 0.419971809937888 -0.410801232603508 0.228395219163808 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CLUH -1.09068180945688 0.0229170358786482 0.326250774279766 -1.1212947446539 0.0189394623548611 0.330467462546779 0.4400709382790589 0.2700431376348431 2.0 -0.421469258712856 0.240531207146127 0.487388923246716 0.125519267975672 0.0659196645338596 0.861071568106089 partial_or_other False True False False False False False 2 insufficient_or_context_specific +MEG9 -1.0261780911919 0.0231570092020889 0.326250774279766 -1.32894708483708 0.0015715866577537 0.207460921631778 False True False False False False False 2 insufficient_or_context_specific +DHRS7B 0.47250621073171 0.0231756090840902 0.326250774279766 0.0967594068719798 0.634230503850719 0.861847932958146 1.26958928534132 1.0 0.57425365333809 0.242804303885342 0.294871274697386 0.451018656118192 0.869124928035476 0.0631522680709077 partial_or_other True False False False True False True 2 residual_state_candidate +ZNF697 1.04191299887155 0.0235840465968362 0.327734533946059 0.912395006246685 0.0485887869286528 0.403619521945488 0.4678549852003471 0.0295269100852599 2.0 True True False False False False False 2 insufficient_or_context_specific +LNCSRLR 1.31163568798568 0.0236052869065064 0.327734533946059 1.32918623121062 0.0222483603292122 0.346028040476539 0.69903039502045 0.0407372196405607 2.0 True True False False False False False 2 insufficient_or_context_specific +KIZ 0.573167336997904 0.0236251860144853 0.327734533946059 0.427889914626028 0.0959418431512536 0.47569521889622 0.0694263472642322 1.0 -0.908906963203753 0.0480695584010483 0.194341845411364 0.634781128238746 -0.714565117792389 0.0899967197591525 persistent True False False False False True False 2 cross_species_direction_conflict +IKZF2 0.797127464692644 0.0236457153453717 0.327734533946059 0.757886282587997 0.0318506766393415 0.375031405408838 0.0293265374807568 1.0 -0.259289961791085 0.683628821522331 -0.174611399356993 0.730710293266917 -0.433901361148078 0.412828726166227 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CREB3L3 -1.17145769529472 0.0236489708508955 0.327734533946059 -1.10327601903591 0.0340201451119356 0.376543096535729 -0.931408037579729 0.054780724759655 1.0278396561578 0.0267961304374739 0.0964316185780736 0.844293963005993 reversed False True False False False False False 2 insufficient_or_context_specific +AC107021.1 1.18345255639875 0.0237317705358778 0.327734533946059 1.23689451007165 0.0182792727060782 0.32629129734252 0.0448832613041107 1.0 True True False False False False False 2 insufficient_or_context_specific +MRPS35 0.553195591185549 0.0237916552642362 0.327734533946059 0.536570046800986 0.0290510837156862 0.369232614592462 True True False False False False False 2 insufficient_or_context_specific +CH25H 1.76765016782546 0.0238536146445042 0.327734533946059 1.74108326575414 0.0263014573522197 0.354273049744177 0.663499128689506 0.278515148841627 0.0379767916610473 3.0 True True False False False False False 2 insufficient_or_context_specific +TIMP1 1.32019508927664 0.0239417944820202 0.327734533946059 1.57392629479105 0.006826372004157 0.282692791660547 0.65778282231711 0.31755130439345 0.260783161225725 3.0 -1.58191015842262 0.303350793900669 -1.57564191992404 0.295497737809961 -3.15755207834666 0.0549533665136731 partial_or_other True True False False False False False 2 cross_species_direction_conflict +FGF7 1.53837939311516 0.0239859779162228 0.327734533946059 1.55594675634802 0.022624389646995 0.346028040476539 0.414196799749708 0.22797743051803 2.0 True True False False False False False 2 insufficient_or_context_specific +CPNE7 2.64104099538118 0.0239896673524678 0.327734533946059 2.61290823344811 0.0254784765749613 0.351006805738558 3.10166178601011 0.0833960440291809 2.0 True True False False False False False 2 insufficient_or_context_specific +SEC24B-AS1 1.14715720214649 0.0240274533751511 0.327734533946059 1.37838717356002 0.0068317929520515 0.282692791660547 0.0433718343565371 1.0 True True False False False False False 2 insufficient_or_context_specific +PHKA2 -0.573483251101089 0.0241282461147616 0.327734533946059 -0.713492258367337 0.0041704472134422 0.254033252149992 -0.136314571434227 0.682427626091247 -0.392982701919451 0.13150272465255 -0.529297273353678 0.0670324052500536 partial_or_other False True False False False False False 2 insufficient_or_context_specific +MBOAT7 -0.493424880793805 0.0241812087463516 0.327734533946059 -0.530773205552522 0.0145833298007109 0.317541556275699 -0.0499294547443134 0.899000427126128 -0.481295435369228 0.083758563752164 -0.531224890113542 0.0736066794318125 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RGS12 -0.422026634872326 0.0242127201172041 0.327740896150565 -0.420419413437038 0.0246443203361312 0.349408136686844 0.276701366807438 0.468845290715915 -0.883831864349187 0.0151611856084994 -0.607130497541749 0.0896932956801522 partial_or_other False True False False False False False 2 insufficient_or_context_specific +GNMT -2.03155863436233 0.0244691168917546 0.32844355033163 -2.09896717331851 0.0194664051609843 0.330467462546779 -1.26339177557266 0.04027293591094 2.09705975868833 0.0038069866811309 0.833667983115666 0.132074106284297 reversed False True False False False False False 2 insufficient_or_context_specific +CYFIP1 -0.365691996463757 0.0244710458889858 0.32844355033163 -0.428553180841025 0.0066456915364023 0.280660844965345 0.182295071757512 0.493616517736783 0.137234661462217 0.527648490775427 0.319529733219729 0.168467507999703 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PNPLA3 -1.71650397650452 0.0244839335860649 0.32844355033163 -1.6923189276321 0.0269317378456277 0.356222495883986 0.282868254145776 0.775277079535413 -0.69944681342738 0.309355906471855 -0.416578559281604 0.639697984928692 partial_or_other False True False False False False False 2 insufficient_or_context_specific +GXYLT2 1.07634777372249 0.0245434990012392 0.32844355033163 1.00256647045866 0.037776205580982 0.379484931484566 0.639456109201712 0.05298017001353799 2.0 -0.392203364958795 0.72307877200797 -1.72513861476006 0.0864342877559602 -2.11734197971885 0.0588306197779767 partial_or_other True True False False False False False 2 cross_species_direction_conflict +RASAL2 0.602030984445681 0.0246090652868228 0.328824846728657 0.6404108621218 0.0158349378122287 0.320853404849916 0.228797924997456 0.276875013226046 2.0 -0.246847076363565 0.649290563012388 0.0563245379393318 0.905484336164122 -0.190522538424233 0.694164662882171 partial_or_other True True False False False False False 2 cross_species_direction_conflict +LRRC45 -1.23225985763932 0.0248819245729673 0.330087379345907 -1.54742781967685 0.0025710052943131 0.224500148429329 -0.272929014594005 0.435232605327832 -0.791457147283588 0.019322906242395 -1.06438616187759 0.0077816149852203 partial_or_other False True False False False False False 2 insufficient_or_context_specific +C14ORF180 -1.68891956619331 0.0249001866036354 0.330087379345907 -1.76343098532832 0.017849396011993 0.32629129734252 False True False False False False False 2 insufficient_or_context_specific +PTPRU 0.845599672247647 0.025108544069742 0.330087379345907 0.755869472668113 0.0463077340319119 0.398741839274603 0.9411559499376311 0.0590708838183481 2.0 -0.179847019049379 0.834983959905929 0.531755834536938 0.307315771456057 0.351908815487559 0.577782193515744 partial_or_other True True False False False False False 2 cross_species_direction_conflict +FBXO17 -0.533470987054089 0.0252903679867975 0.330087379345907 -0.488211518255013 0.0429853116629674 0.391483132487066 0.347107257906888 1.0 0.442063167761699 0.391090359853093 -1.6266082775265 0.0050898248201365 -1.1845451097648 0.0396757426500509 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RAB40B -0.729663677498589 0.0253866522368046 0.330087379345907 -0.796384458111969 0.0143404903162113 0.316089554819539 0.325688502841503 1.0 -0.783271654820415 0.126091903712372 -0.117964044019559 0.810936831869903 -0.901235698839974 0.0703116758008396 partial_or_other False True False False False False False 2 insufficient_or_context_specific +BST2 0.908022738150271 0.0254323553856217 0.330087379345907 0.869019377208744 0.0322468147905324 0.375031405408838 -0.127745051197235 0.759521321408178 0.313145303788205 0.321188067554506 0.18540025259097 0.590034275997834 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CAD -0.635214551578569 0.0254514654956473 0.330087379345907 -0.608104152736932 0.0328625015122835 0.375130164525249 0.330837881937787 0.362784596756343 -0.50985605923389 0.0946434125532968 -0.179018177296102 0.612589927930674 partial_or_other False True False False False False False 2 insufficient_or_context_specific +POLR3H -0.836972486708503 0.0255480657034534 0.330087379345907 -0.917584709591499 0.0122798801435843 0.309429533546452 0.7813332311452981 0.522715024961017 2.0 0.271788071308789 0.454899803577486 0.157420536485676 0.590343299584368 0.429208607794466 0.178919164020884 partial_or_other False True False False False False False 2 insufficient_or_context_specific +LY6E-DT 0.856767028922606 0.0255591750003532 0.330087379345907 1.01075622879987 0.0083553271305395 0.288286090994236 0.0534659479889229 1.0 True True False False False False False 2 insufficient_or_context_specific +RPAP2 0.346928818237056 0.0256343137729781 0.330087379345907 0.349861880266656 0.02404352023464 0.349176735402103 -0.165192879908419 0.678260613080628 -0.127585208286605 0.687063923052911 -0.292778088195024 0.373868706996442 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CLEC2D 0.776312325747725 0.0256465563267646 0.330087379345907 0.571881479579015 0.106138359832666 0.483261130274234 0.0777756163465184 1.0 -0.896789760159921 0.0217624730850584 0.0814104786335748 0.819341012435221 -0.815379281526346 0.0303524188451113 persistent True False False False False True False 2 cross_species_direction_conflict +NPC1L1 -1.53648943754272 0.0257003962007016 0.330087379345907 -1.49322892466363 0.0311891757815507 0.375031405408838 False True False False False False False 2 insufficient_or_context_specific +SLC25A45 -1.00261573229215 0.0257683217115466 0.330087379345907 -1.14017402710873 0.0088433621594429 0.291509786412688 0.468372354391335 0.3862120913030329 2.0 0.202942716142477 0.508342971421694 -0.349480737615352 0.159907267556915 -0.146538021472874 0.602338874331942 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SYN3 0.794731928598034 0.0257699820177024 0.330087379345907 0.361727991448193 0.295468245165117 0.653036159190561 0.248631294401155 1.0 -2.85243242104665 0.003091207359983 1.36870438305145 0.0870638706644835 -1.4837280379952 0.0328482704143711 persistent True False False False False True False 2 cross_species_direction_conflict +PEMT -0.910120884497892 0.025786143224844 0.330087379345907 -0.836076880521377 0.0428287222171691 0.391483132487066 0.544665146750444 1.0 -0.510712647837486 0.303184869644774 0.956712528609969 0.0394152404890652 0.445999880772483 0.318814162767615 partial_or_other False True False False False False False 2 insufficient_or_context_specific +BX322234.1 1.35366154642011 0.0258911874269614 0.330087379345907 1.66631099405772 0.0062285688511642 0.27151085227822 0.0571040750221642 1.0 True True False False False False False 2 insufficient_or_context_specific +VEZT 0.451682056764981 0.025918018325228 0.330087379345907 0.455178822424084 0.0246394540408924 0.349408136686844 0.128746228551758 0.0916242433329184 2.0 -0.0349940550871174 0.932237494304634 -0.471403117392419 0.0909218964451135 -0.506397172479537 0.0935625662874974 partial_or_other True True False False False False False 2 cross_species_direction_conflict +ZC3H18 -0.579807082171644 0.0260086651049404 0.330444628372997 -0.699080642748251 0.0049674507286172 0.264880529256269 -0.059279831201579 0.866380752549383 -0.0529685058958862 0.844270650188955 -0.112248337097465 0.688030642577983 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZC3H13 -0.686022943518975 0.0261383697523813 0.330935942403272 -0.856062266361364 0.0037552234869539 0.243764662040058 0.0300348661559935 0.936374729622049 -0.148708166605692 0.556825176857364 -0.118673300449699 0.683169836203475 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SLC25A44 -0.853338953288183 0.0262620632771005 0.330935942403272 -0.782165833219061 0.0434979221113834 0.392214551124798 -0.281701080731857 0.41411445497107 0.247082216052649 0.391175780285911 -0.0346188646792078 0.923039687876531 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PGK1 0.886575195656033 0.026311677125647 0.330935942403272 0.766779292747559 0.0597938458236363 0.428473540531152 0.0586665814522906 1.0 0.799702697696857 0.352659429781713 0.662313855767677 0.289644045918174 1.46201655346453 0.0633957026815576 partial_or_other True False False False True False True 2 residual_state_candidate +AC025180.1 1.34435972144132 0.0263298614670942 0.330935942403272 2.08027342086294 0.0006480731337703 0.170662739118283 0.035183382422896 1.0 True True False False False False False 2 insufficient_or_context_specific +SLC40A1 0.643354578221844 0.0265699483158105 0.331425407194067 0.520771473834006 0.0814315020929301 0.461068439742811 0.537728694503267 0.488568731475812 0.0660988628195208 3.0 0.536303992779162 0.119162721746335 0.0692756471378886 0.83449781679817 0.605579639917051 0.0674775932298952 partial_or_other True False False False True False True 2 residual_state_candidate +HLA-A 0.730642938566406 0.0266525009701935 0.331425407194067 0.793818636934929 0.0152387818279255 0.320500116612027 True True False False False False False 2 insufficient_or_context_specific +IL17RC -0.635532023215006 0.0269286520266319 0.333062456906093 -0.645247304802632 0.0243472291770537 0.349408136686844 0.9866825568143549 1.0 -0.157363828146572 0.655892579572476 -0.349291094350411 0.206225090688163 -0.506654922496983 0.0948428153008631 partial_or_other False True False False False False False 2 insufficient_or_context_specific +LRCH4 -0.759286339269416 0.0270033588853586 0.333062456906093 -0.770892028812797 0.0243889687338965 0.349408136686844 -0.17080850544314 0.56162803455884 -0.374680278829715 0.124772176662998 -0.545488784272855 0.0433232706511173 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CYP4F2 -1.62332017419206 0.0270761930450924 0.333184430855367 -1.69178238658839 0.0201216611205646 0.332725011651872 False True False False False False False 2 insufficient_or_context_specific +RFX1 -0.729883356759956 0.0272868245806893 0.333442469818192 -0.842398063868239 0.0100818048822473 0.302245517751671 0.4535890493266571 1.0 -0.0804470958756788 0.775672964860777 -0.454722303404688 0.0431018401756332 -0.535169399280367 0.0303524188451113 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ANXA4 0.425788259266163 0.0273856986039006 0.333641420347605 0.462746593950421 0.0164193150180357 0.325244142514861 0.7343663568351879 1.0 -0.26307354098566 0.37989604183926 0.629129585510193 0.0226406830380431 0.366056044524532 0.16765676831985 partial_or_other True True False False False False False 2 cross_species_direction_conflict +SEMA3C 1.0019222604688 0.0274650857521087 0.333988882696468 1.03195875704138 0.0232363224066696 0.346051520554005 0.540242147625471 1.78106318553808 0.110449288830079 3.0 -2.30170898998946 0.0058062164817886 1.33012596858238 0.0527569222319042 -0.971583021407084 0.120865490121335 reversed True True False False False False False 2 cross_species_direction_conflict +AC090568.2 0.569497484003905 0.0277189617511991 0.335231154832944 0.578312620234855 0.0254255463274565 0.351006805738558 0.0522982516755256 1.0 True True False False False False False 2 insufficient_or_context_specific +KDM4B -0.718478338306258 0.0278393957791878 0.335848858237946 -0.899959608910008 0.0031639533960547 0.231979305246845 0.769894365514576 0.5396711006632701 2.0 -0.0082152821386784 0.985691712881774 -0.354390080675581 0.229195843335286 -0.362605362814259 0.257790338983274 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CUEDC1 -0.488380548323325 0.0278654669271113 0.335848858237946 -0.485394904160618 0.0288568471138885 0.368404585040429 0.718005260067429 1.0 -0.208209035856748 0.521096519452704 -0.247767264753115 0.354139099057035 -0.455976300609862 0.111553482731439 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ALS2CL -0.829933140087132 0.0280089448286708 0.33719320353604 -0.521399797034685 0.196910176647825 0.571879675616801 0.59545033222985 1.0 -0.912029079861941 0.0141845433167293 -0.391351298085744 0.209556459143735 -1.30338037794769 0.0037937910940437 persistent False False False False False True False 2 insufficient_or_context_specific +GMEB1 -0.512538898727533 0.0281963408499838 0.337541516609551 -0.672464565455326 0.0023072673613764 0.223491901031981 -0.223456802911421 0.532227623439228 -0.555201594613106 0.0700313405959671 -0.778658397524526 0.0268191252583034 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CEMIP 1.52166512636906 0.0281977285138874 0.337541516609551 1.72481662696783 0.0132376388917581 0.313114831651016 0.0481854036770496 1.0 True True False False False False False 2 insufficient_or_context_specific +DOT1L -0.734682364367105 0.0283483982347252 0.338757833934729 -0.757389290339559 0.0230470089598924 0.346051520554005 0.876785649180533 0.458557732258191 2.0 0.0734774121963709 0.856375858040323 -0.461963902049006 0.106258932652199 -0.388486489852635 0.198157856820249 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SLC51A -0.935995808923073 0.0283955941496718 0.338757833934729 -1.10059172630263 0.0075854844198936 0.287862310479138 False True False False False False False 2 insufficient_or_context_specific +ACADS -0.828924237679086 0.0285198853539459 0.339856602220047 -0.895560525274407 0.0162840838162313 0.325004455447581 -0.675735854547024 0.0641495577533093 1.00619100997133 0.008523606597852 0.330455155424308 0.312725565366547 reversed False True False False False False False 2 insufficient_or_context_specific +ACVR1B 0.523484329428726 0.0285891652570993 0.339914872505016 0.488482122734714 0.042070261529476 0.3908928278867 0.125219440659688 0.112785029082645 2.0 -0.381941881334408 0.597847856752033 -0.230054869391236 0.703049977644701 -0.611996750725644 0.323463038417611 partial_or_other True True False False False False False 2 cross_species_direction_conflict +LINC02055 -1.73904436027655 0.0288153386659255 0.341067652056998 -1.95764492844462 0.0128219752154004 0.313114831651016 1.26706435721133 1.0 False True False False False False False 2 insufficient_or_context_specific +TNK2 -0.66783515739276 0.028948024805902 0.341108533371332 -0.655882167140771 0.0325012992919017 0.375031405408838 1.27210973537993 1.0 -0.317841280150793 0.319547673789427 -0.316992857816578 0.250320124524464 -0.634834137967372 0.0428603393030914 partial_or_other False True False False False False False 2 insufficient_or_context_specific +MYOCD 1.36327971943296 0.0291205425762097 0.342001418870157 1.98002250319597 0.0021804713358093 0.223491901031981 1.44643482040778 0.0545475657746114 2.0 True True False False False False False 2 insufficient_or_context_specific +TTN-AS1 0.47907615187722 0.0291563137738708 0.342001418870157 0.466605116578146 0.0338438060139012 0.376543096535729 0.6099329983492691 0.0666944571984223 0.0754641673205128 3.0 True True False False False False False 2 insufficient_or_context_specific +CHMP1A -0.69976049842767 0.0292863086597951 0.342330691391477 -0.68687443849166 0.0327672118037847 0.375031405408838 -0.0626241683250676 0.841732265685156 0.0529234938305787 0.824647429008664 -0.0097006744944889 0.972579648489636 partial_or_other False True False False False False False 2 insufficient_or_context_specific +MCTP1 0.999618320343066 0.0295689456268599 0.342436744765113 1.38126357437013 0.00227445377703 0.223491901031981 0.0338723803612241 1.0 True True False False False False False 2 insufficient_or_context_specific +CECR2 -0.772926742111322 0.0295971864405683 0.342436744765113 -0.800897466822415 0.0236429498459991 0.348898908348731 -0.565513321231772 0.43818386322322 0.584982686637176 0.293630028905344 0.0194693654054042 0.979881713598889 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ASPSCR1 -0.719779820024019 0.0296016298604525 0.342436744765113 -0.948462903799379 0.0029220137534285 0.226842803005138 0.5224387016986339 1.0 -0.440079665883768 0.0765505507354345 0.0307126764695727 0.90401365135368 -0.409366989414196 0.082222617927494 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PCSK5 0.609971379781699 0.0296044671615434 0.342436744765113 0.395413139057865 0.177121495545161 0.559392387067247 -1.11952894780926 0.0010043557212465 0.33214298053368 0.154659407023425 -0.78738596727558 0.008457030093391 persistent True False False False False True False 2 cross_species_direction_conflict +DYNC2H1 0.502289660326931 0.0296493862933037 0.342436744765113 0.51863719530326 0.0241564827048523 0.349408136686844 0.150917771228487 0.134845975829678 2.0 True True False False False False False 2 insufficient_or_context_specific +PLCXD1 -1.03260635811189 0.0298096920708777 0.343028363112338 -1.17837732163731 0.0105654512182468 0.302245517751671 False True False False False False False 2 insufficient_or_context_specific +PPP1R12C -0.71285730658792 0.0299028641609213 0.343028363112338 -0.756392782709698 0.0206350223794936 0.333389311130767 0.476519996315271 0.36144699865447 2.0 0.0526915013410644 0.865727255314412 -1.0616185575926 0.0014550940008916 -1.00892705625154 0.0029903730695318 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TSTA3 -1.20291270031764 0.0299108043515209 0.343028363112338 -1.13054876236108 0.0446651361993945 0.393650849907072 0.0738762455059238 0.853280537748676 -0.114144688944602 0.691303649087595 -0.0402684434386777 0.90797285001652 partial_or_other False True False False False False False 2 insufficient_or_context_specific +REXO1 -0.673500474414473 0.0299231978051206 0.343028363112338 -0.783440296598326 0.0077420593036652 0.287862310479138 0.347974411769221 1.0 -0.486811080182454 0.215892660154575 -0.013784299606995 0.972450972033354 -0.500595379789449 0.170484818695051 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RPS14 0.573064769730492 0.0300109667425042 0.343661374042689 0.703274616514317 0.0077968418949288 0.287862310479138 True True False False False False False 2 insufficient_or_context_specific +SLC29A1 0.928530345300817 0.0302351484011639 0.344732933930333 0.960605900529423 0.0253006531921222 0.351006805738558 0.745996811021547 0.326787551369768 0.0520143939702699 3.0 -0.735395523604126 0.0109765440721534 0.719865401022062 0.0098922457446224 -0.0155301225820636 0.956201636867624 reversed True True False False False False False 2 cross_species_direction_conflict +ZNF292 0.514375739102215 0.0308881483078302 0.347302523784953 0.512493400619758 0.0314753692022022 0.375031405408838 0.0926519817048911 0.0927285724768039 2.0 True True False False False False False 2 insufficient_or_context_specific +OSBPL9 0.494877735423883 0.0312115047098377 0.349820665314721 0.476586518769068 0.0384713501433258 0.379484931484566 1.21730338081147 0.246504766343492 0.300249997710689 3.0 -0.274106744860434 0.249204168157042 0.528906433666202 0.0216498041479773 0.254799688805768 0.238689921016844 partial_or_other True True False False False False False 2 cross_species_direction_conflict +CBLC -1.52522809994654 0.0312960037024538 0.349912402212569 -1.50025158283575 0.0350060694591784 0.37720666979567 -0.334358086773596 0.345099021716063 0.121946167459143 0.697083567896669 -0.212411919314453 0.51700803469338 partial_or_other False True False False False False False 2 insufficient_or_context_specific +LAPTM4A 0.516595364912892 0.0314667169555149 0.3510183929398 0.412750248801227 0.0895360588723004 0.470746198832535 0.0328224127939234 1.0 0.190149191138018 0.626155500622573 1.33222934668394 0.0017718904708568 1.52237853782196 0.0021299557258438 partial_or_other True False False False True False True 2 residual_state_candidate +THAP6 0.597874537627047 0.0316196851383392 0.351677425598451 0.785532060742865 0.0040922566365703 0.252666933151519 0.0576673151963983 1.0 True True False False False False False 2 insufficient_or_context_specific +MFN2 -0.473084134414325 0.0318025767004667 0.351849953588893 -0.634528840661077 0.0023209380126115 0.223491901031981 -0.227495470243815 0.394852749485657 0.398867344270139 0.0807629273793783 0.171371874026324 0.475504826285827 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ALPL -1.3028581200017 0.0318153219929067 0.351849953588893 -1.20732514937392 0.0494397251984869 0.404880644205143 0.307442219246753 0.706392398219188 2.0 0.648281496102931 0.148618011717146 -0.109675657392161 0.785358527720079 0.53860583871077 0.194546743898624 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ALDH1L2 1.14959190974987 0.0319524143449297 0.352489948368348 1.59361042847045 0.0027421570356009 0.224500148429329 0.0482779886729524 1.0 True True False False False False False 2 insufficient_or_context_specific +IGSF23 -1.86673555557327 0.0321222908252376 0.352695607872978 -2.05585624015468 0.0161515097888658 0.322969015815994 False True False False False False False 2 insufficient_or_context_specific +LLGL2 -0.802010027473076 0.0323186327052939 0.353229942135086 -0.884003926700478 0.0166881839981847 0.325489753822016 -0.210160994671705 0.663818197145994 -0.340350352985227 0.365991737449 -0.550511347656932 0.174905235770204 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ADAM33 1.05009910823122 0.0324761549448387 0.353852676891235 1.14970521489884 0.0193879435516609 0.330467462546779 0.29582053874018 0.0993220251270549 2.0 -0.820077780530692 0.123754163442415 0.194638293982872 0.690664542079804 -0.625439486547819 0.198157856820249 partial_or_other True True False False False False False 2 cross_species_direction_conflict +SESN3 0.884274751544117 0.0330509176471954 0.35660210579473 0.754711084123564 0.0705048719731179 0.443089546602487 0.394218257595293 1.47704792065677 0.110553136083079 0.126080967647753 4.0 0.486689330824008 0.0528521624822698 -0.512380080060739 0.0270728474915667 -0.0256907492367304 0.924880483942295 partial_or_other True False False True False False True 2 insufficient_or_context_specific +BASP1 0.587219085468176 0.0334031283672071 0.356792055793388 0.695027921354039 0.0109878416970195 0.302570357129259 0.639821995236271 0.0432062860551526 2.0 -1.22676371196561 0.131583792260853 -0.455562309164321 0.548069692673409 -1.68232602112993 0.0412143987170608 partial_or_other True True False False False False False 2 cross_species_direction_conflict +RANGAP1 -0.677754826495707 0.0334472829030839 0.356792055793388 -0.683255587686671 0.0319281537215191 0.375031405408838 0.335398443389788 0.270185233851751 -0.0124286142718436 0.967064446935449 0.322969829117944 0.246629876351643 partial_or_other False True False False False False False 2 insufficient_or_context_specific +LAMA3 1.08842617949032 0.033496150331474 0.356792055793388 1.50379470337786 0.0028117999365707 0.224500148429329 1.09962740580461 1.71245272642097 0.0321754319785084 3.0 -0.46744587609073 0.503240344251377 0.052455219805877 0.934015491906489 -0.414990656284853 0.501188119697174 partial_or_other True True False False False False False 2 cross_species_direction_conflict +USP53 0.847972843887421 0.0335045724659499 0.356792055793388 0.243519404004089 0.565008804301486 0.823754286312897 0.6560418216264859 0.115480328795137 2.0 -0.902290922721536 0.0386311512033487 0.0429257528073231 0.922303925332275 -0.859365169914213 0.0405196423106954 persistent True False False False False True False 2 cross_species_direction_conflict +KCTD20 -0.690801799258172 0.0335490872498544 0.356792055793388 -0.856698664434877 0.0058541085889098 0.266412407248749 0.969092040844845 0.9259579910359241 2.0 0.0720644094544803 0.855224142933824 0.120085590833895 0.661208120838912 0.192150000288375 0.51729076550766 partial_or_other False True False False False False False 2 insufficient_or_context_specific +DNM3OS 0.694047535509087 0.0337515826296647 0.357997905551035 0.813186845188568 0.0103156919455856 0.302245517751671 1.51238557087665 0.0843782948278927 0.103867700287084 3.0 True True False False False False False 2 insufficient_or_context_specific +TBXA2R -0.840592325806665 0.0342776162022087 0.36190307186292 -0.888935796621755 0.0235769277223097 0.348898908348731 0.262981440368066 1.0 1.05578407449713 0.102513978234068 -0.0666131476135078 0.899903010515023 0.989170926883625 0.105055826582113 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RPL32 0.579075775653735 0.0347917466737735 0.363322396620508 0.748874705119246 0.0058111559098612 0.266412407248749 0.0388682020966069 1.0 True True False False False False False 2 insufficient_or_context_specific +SCARB1 -0.771600708712386 0.0348665566032627 0.363322396620508 -0.940300144855646 0.0078405057368996 0.287862310479138 0.8882253995601851 0.8249919322416629 2.0 -0.98262604064664 0.0103461786531277 0.603763835589489 0.0610121961528457 -0.378862205057152 0.232737350148126 reversed False True False False False False False 2 insufficient_or_context_specific +C1ORF54 0.815920770666068 0.0350362572746329 0.363322396620508 1.12732687255768 0.0027892773450032 0.224500148429329 0.0303553996707328 1.0 True True False False False False False 2 insufficient_or_context_specific +SPTBN2 -1.16011507868252 0.0351641634139209 0.363322396620508 -1.30146968472879 0.0169910453274415 0.326204572615871 -0.91071352999303 0.0154809105588594 0.708386478687835 0.0317985347883383 -0.202327051305195 0.53312064839256 reversed False True False False False False False 2 insufficient_or_context_specific +KCNT2 0.494446986410503 0.0352951065539489 0.363322396620508 0.526517852869861 0.0232330308159831 0.346051520554005 -0.185904642357801 0.733293239134051 -0.0065171977888029 0.989326860416828 -0.192421840146604 0.68445714126385 partial_or_other True True False False False False False 2 cross_species_direction_conflict +PYM1 -0.609634342325108 0.0353067606490473 0.363322396620508 -0.313966192453656 0.305037002080707 0.661381253594365 -0.878323013008886 0.0589767412598953 -0.684742796800794 0.102398273256228 -1.56306580980968 0.0056996297641849 persistent False False False False False True False 2 insufficient_or_context_specific +CARM1 -0.607976497809467 0.0354158063677326 0.363735489912958 -0.619304547372812 0.0317308455105816 0.375031405408838 0.25118117360058 0.5450270224775329 2.0 0.0689427964150892 0.826654578927004 -0.185059344916982 0.403338249577107 -0.116116548501893 0.644387650688514 partial_or_other False True False False False False False 2 insufficient_or_context_specific +MECOM 1.06865095264224 0.0355241963284927 0.364080686597539 1.01849419141772 0.0459970487094234 0.398062983831224 1.12818971888668 1.0 True True False False False False False 2 insufficient_or_context_specific +CPSF7 -0.312704400097238 0.0360784795087435 0.365949036346115 -0.300860450724102 0.0435088088839697 0.392214551124798 -0.250752124611455 0.397680847316268 -0.364613251266546 0.154160694223555 -0.615365375878001 0.0345419603450933 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PSMB5 0.534603598980839 0.0366299987709137 0.367878261820445 0.549128946993529 0.0324427489268349 0.375031405408838 0.265997150223245 0.0215587143055309 2.0 -0.0944956987070363 0.83289069999139 0.229005632528791 0.475681458786282 0.134509933821754 0.70983486516815 partial_or_other True True False False False False False 2 cross_species_direction_conflict +ERO1A 0.890013016225798 0.0366975035285056 0.367950847344693 0.855205728658511 0.0455568178832464 0.396201715989551 0.0208674707512821 1.0 True True False False False False False 2 insufficient_or_context_specific +MT-ATP6 -0.562253626450066 0.0368975610280476 0.368139714899329 -0.544813676378189 0.0436278701077256 0.392214551124798 -0.31310224066286 0.560834622024947 0.437395530177794 0.32198119991838 0.124293289514934 0.808357610526879 partial_or_other False True False False False False False 2 insufficient_or_context_specific +IFI44L 1.13358489940061 0.0373722524921267 0.368446063719788 1.19568829641284 0.0286546279590708 0.367950586134951 True True False False False False False 2 insufficient_or_context_specific +NUP188 -0.524925016161348 0.0374275532444613 0.368446063719788 -0.536316905264125 0.0329649662708789 0.375130164525249 -0.219951711212715 0.574965721644244 -0.389388746467892 0.217704274895162 -0.609340457680606 0.0820551708164605 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TSPAN5 0.984563886583181 0.0374296829880067 0.368446063719788 0.939658344924089 0.0473701607283975 0.401231297569097 0.0206435684532643 1.0 -0.928747945376182 0.221666972647525 0.92482992882925 0.132840569830826 -0.0039180165469318 0.996375285485947 partial_or_other True True False False False False False 2 cross_species_direction_conflict +PDCD11 -0.692853497756353 0.0374680684561203 0.368446063719788 -0.733095003307683 0.0255198685191895 0.351006805738558 -0.0343013324034807 0.911240264788933 -0.420146482218208 0.0556217604315032 -0.454447814621689 0.0525662646265311 partial_or_other False True False False False False False 2 insufficient_or_context_specific +WNT5B -0.98053877733671 0.0375295283666511 0.368446063719788 -1.40387173212974 0.0025377723359447 0.224500148429329 0.0429874376041409 0.952676030958 -0.42584608835048 0.366386543030918 -0.382858650746339 0.476727955479374 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZNF598 -0.767586220829798 0.0375433807146294 0.368446063719788 -0.760479443669106 0.0397313645754164 0.381348861079315 0.551696318141082 1.0 False True False False False False False 2 insufficient_or_context_specific +GRK5 -0.444252860517135 0.0376193272106394 0.368446063719788 -0.475108483197505 0.0231008571202652 0.346051520554005 0.124445951668731 0.6983733690462829 2.0 0.163572735320049 0.70754626250293 -0.757098465765224 0.0402647271604851 -0.593525730445175 0.105000749942876 partial_or_other False True False False False False False 2 insufficient_or_context_specific +HPN -1.30967100519061 0.0377182768215442 0.369072814348345 -1.36618824690424 0.0296339655986554 0.371414855918995 -0.710227557614326 0.0939689646649818 0.303102368152763 0.417766581338 -0.407125189461563 0.2942240725071 partial_or_other False True False False False False False 2 insufficient_or_context_specific +BX255925.3 -0.970536164308683 0.0378627661790201 0.369545139957322 -1.00174957996224 0.0311134785447811 0.375031405408838 False True False False False False False 2 insufficient_or_context_specific +FAM49B -0.546538333638056 0.0379346860666758 0.369545139957322 -0.552027377016611 0.0358973594983547 0.37720666979567 -0.331868915320755 0.36004710290144 -0.0881114776844232 0.791211665451979 -0.419980393005178 0.200097280541583 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ZNF414 -0.986803908401477 0.0379444931191089 0.369545139957322 -1.1028354390776 0.0188493070532201 0.330115789697373 1.11249629985432 1.0 False True False False False False False 2 insufficient_or_context_specific +ZBTB48 -0.717522885370781 0.0380371782277604 0.369783926354916 -0.77459416585368 0.0229152773694416 0.346028040476539 0.9526163162701009 1.0 -0.0711411174795235 0.8801648634959 -0.779530374893574 0.0307262134175377 -0.850671492373097 0.0310400593280158 partial_or_other False True False False False False False 2 insufficient_or_context_specific +YKT6 -0.56394040525675 0.0381482488217066 0.370192289576818 -0.545453636794482 0.045650857498182 0.396366573573853 0.309634051926234 1.0 0.470393640778768 0.142081740538008 -0.0557635693911775 0.856393127732316 0.41463007138759 0.163234880761322 partial_or_other False True False False False False False 2 insufficient_or_context_specific +DNAJB14 0.314533254522734 0.0384532174055487 0.371584398994206 0.318935573258672 0.0353744358399819 0.37720666979567 -0.01309199492254 0.969729400228664 0.181123416146515 0.426186842736189 0.168031421223975 0.506580730079599 partial_or_other True True False False False False False 2 cross_species_direction_conflict +RPL28 0.60881830608661 0.0386397969003311 0.371584398994206 0.626447497803844 0.0332646371123312 0.376280667109215 0.8020587869596172 0.424273867061622 2.0 True True False False False False False 2 insufficient_or_context_specific +PDZD2 0.702502221594244 0.0386787974022163 0.371584398994206 0.439059966775712 0.196756040883365 0.571879675616801 -1.35710033655649 0.0113180006640485 0.404490672903401 0.355523158408844 -0.952609663653089 0.04228228563039 persistent True False False False False True False 2 cross_species_direction_conflict +FAM206A 0.684733713124954 0.0386788458509787 0.371584398994206 0.725230821253726 0.0287325784185555 0.368153595804744 0.0146003621899966 1.0 True True False False False False False 2 insufficient_or_context_specific +RPS23 0.888035525443975 0.0388036114508231 0.371768175769319 0.887526474671673 0.0392720216209121 0.379484931484566 True True False False False False False 2 insufficient_or_context_specific +CACFD1 -0.953940160733473 0.0392075270539974 0.374084143383926 -1.08430633496248 0.017244731860656 0.326204572615871 -0.227969680307983 0.311968659832509 -0.40803553338509 0.0497029060802903 -0.636005213693073 0.0113234580901949 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PNPLA6 -0.649182860751572 0.0392401518664029 0.374084143383926 -0.653930306671463 0.037710917408146 0.379484931484566 0.393160174347753 0.567015502079143 2.0 -0.372362717265899 0.140018931204312 -0.666613779918248 0.011607751173525 -1.03897649718415 0.0028179621895243 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PDIA5 -0.559608034522486 0.0393067147168674 0.374211265987995 -0.370361777849374 0.173678416963521 0.55532911153872 -0.821883429083437 0.0102133756378536 0.0975739538439766 0.719624042410407 -0.72430947523946 0.019553149402753 persistent False False False False False True False 2 insufficient_or_context_specific +RPL35A 0.521011315341931 0.0395249457299654 0.374868680542814 0.587090443906267 0.0192274883843171 0.330467462546779 0.319029725547996 1.0 True True False False False False False 2 insufficient_or_context_specific +SERP1 0.491510548880457 0.0396590038365041 0.374868680542814 0.240031240881459 0.307696363984101 0.662243470533128 0.0368680133941234 1.0 0.248195224379527 0.565217264065263 0.674978922675028 0.0490945659282042 0.923174147054555 0.0232417945936453 partial_or_other True False False False True False True 2 residual_state_candidate +ZNF316 -0.682623899333478 0.0396598139956737 0.374868680542814 -0.866700689039406 0.0052033134214387 0.265121723850427 False True False False False False False 2 insufficient_or_context_specific +CADPS 1.77788365758966 0.0400052056435979 0.376490056204699 2.55612816658781 0.0039812392162079 0.249865883941099 0.0911964077078938 1.0 True True False False False False False 2 insufficient_or_context_specific +ATAD3A -0.70767211541842 0.0402148862494295 0.377352391526232 -0.692629668989529 0.0454391987933286 0.395939713713768 -0.348103542905526 0.182560032256214 -0.162312918798034 0.482746145075091 -0.51041646170356 0.0475946479214771 partial_or_other False True False False False False False 2 insufficient_or_context_specific +MYO16 -1.15255802525361 0.0403918723329025 0.377731883491073 -1.26682984805231 0.0228187470528114 0.346028040476539 False True False False False False False 2 insufficient_or_context_specific +SHMT1 -1.03972362551086 0.0405182995539519 0.377731883491073 -1.30133402044623 0.0078384016956174 0.287862310479138 -0.293588502304569 0.54197599541736 0.673620192951943 0.09004146456268 0.380031690647374 0.352538856816546 partial_or_other False True False False False False False 2 insufficient_or_context_specific +HMGN1 0.65375628160033 0.0406994197051059 0.377928296610825 0.732287841856402 0.0215860154971087 0.341686883985718 -0.0336512204053543 0.94349300890502 -0.587902002269477 0.0758372035063263 -0.621553222674831 0.082222617927494 partial_or_other True True False False False False False 2 cross_species_direction_conflict +PEX16 -0.818606526020668 0.040864398379942 0.378583287897352 -0.974762372882194 0.0122673887901669 0.309429533546452 -0.433106821044578 0.178247833356636 0.0787578724956961 0.795382950535483 -0.354348948548882 0.231574769772191 partial_or_other False True False False False False False 2 insufficient_or_context_specific +TMEM184B -0.387947774634383 0.0408775287178426 0.378583287897352 -0.449531561687189 0.014223127901441 0.316089554819539 0.9361672905748941 0.6161448478833891 2.0 0.660359900859962 0.02280319287148 -0.351393331654478 0.143360777460151 0.308966569205484 0.225970717950124 reversed False True False False False False False 2 insufficient_or_context_specific +RPLP1 0.800092221299056 0.0416605336045415 0.383572450100128 1.0128830816266 0.0097032173967863 0.300429821921613 0.303371977285293 0.777442470213394 0.0244234154677137 3.0 True True False False False False False 2 insufficient_or_context_specific +MAP1LC3B 0.636295268140237 0.0421339411619077 0.383730849135154 0.262028451262719 0.388879864373027 0.721961246360193 0.0622717741837499 0.860471158687774 0.876217296030679 0.0049476344620666 0.938489070214429 0.0056360310187644 partial_or_other True False False False True False True 2 residual_state_candidate +HSBP1L1 -0.552402268851001 0.042148925717051 0.383730849135154 -0.752719945777646 0.0034947182782662 0.243710520549117 False True False False False False False 2 insufficient_or_context_specific +PTH1R -0.814346799257025 0.042154876816134 0.383730849135154 -0.89579789949481 0.023599005756846 0.348898908348731 0.8185548130087021 0.9101834599032791 2.0 -0.358732097476591 0.382056581437292 0.451493203487212 0.201719290107292 0.0927611060106212 0.822378917549632 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PMM1 -0.838792520528955 0.0423558039070993 0.383730849135154 -0.835351398826522 0.0435873550034731 0.392214551124798 -0.109121369645645 0.815553359534416 -0.118083184974402 0.734622819714343 -0.227204554620048 0.540174084592687 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ACSS3 0.529145708852649 0.0424873425496301 0.383730849135154 0.372535191801884 0.159480256668985 0.543271287169906 0.758618441108984 0.232296375267035 1.15611291592435 0.018536714289662 1.91473135703334 0.0063057817677493 partial_or_other True False False False True False True 2 residual_state_candidate +KNG1 -0.824417277162693 0.0426214589765502 0.383949763302995 -0.880123325553872 0.0288346930097704 0.368404585040429 -0.517332804737104 0.318163365824631 1.09674506648182 0.0286031397647717 0.579412261744716 0.218497863534618 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CLIC6 1.35552693577238 0.0427718560624002 0.383949763302995 1.83112934692912 0.0069915060695045 0.282692791660547 0.0468836818897702 1.0 True True False False False False False 2 insufficient_or_context_specific +SUCLG1 0.305560211803626 0.0429175479973386 0.383949763302995 0.280650805006797 0.0644429854439575 0.433921581835015 0.0974698174083224 0.859070568791721 0.938140066736547 0.0226406830380431 1.03560988414487 0.0223341774081955 partial_or_other True False False False True False True 2 residual_state_candidate +ABI3BP 0.890206277144161 0.0429324023465733 0.383949763302995 0.958674954827789 0.0284554985698921 0.367277694255405 0.8230772038732951 0.3649706727894529 0.140691742305024 3.0 -1.29763120572526 0.005640031554683 1.54332698810473 0.0022054600468663 0.245695782379471 0.507310676018805 reversed True True False False False False False 2 cross_species_direction_conflict +AP1B1 -0.808897776720091 0.0434509021456015 0.384538662911367 -0.978685302058064 0.0108349903587366 0.302570357129259 0.8765411435926551 1.0 -0.162822542180326 0.557228218475799 0.229854577592961 0.297650276382847 0.0670320354126351 0.79853669997117 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SLC27A3 -0.881818320099991 0.04361621107146 0.385082844493601 -0.860415788032906 0.0499561648421133 0.40534943521819 False True False False False False False 2 insufficient_or_context_specific +MLLT1 -0.67027074642737 0.0436930870135573 0.385082844493601 -0.706808458355888 0.0311930630029964 0.375031405408838 0.924469907233435 0.495472897109515 2.0 0.354939064430701 0.209483916909758 -0.408119619059827 0.0981744073757345 -0.0531805546291262 0.860846059123541 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PTPRH -0.940070968510493 0.0440437608382368 0.386657243898202 -0.973671523716285 0.0358202857914955 0.37720666979567 False True False False False False False 2 insufficient_or_context_specific +CTBP1 -0.40655927265221 0.0440565130147317 0.386657243898202 -0.443906577255947 0.0276345634898416 0.361656300887855 0.532570948610319 1.0 -0.111356042716696 0.646455831565373 0.207209355562194 0.275102635365299 0.095853312845498 0.654588223119792 partial_or_other False True False False False False False 2 insufficient_or_context_specific +DDX11 -0.778859583114485 0.0442452388287209 0.387669747231417 -0.983316909281802 0.0090799340173124 0.294972133399338 -0.0749222166667082 0.875823233133227 -0.964029606354896 0.014285614721208 -1.0389518230216 0.0171952829966986 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FTO 0.413638242559259 0.0442820340179095 0.387669747231417 0.424338901573464 0.0381960430552829 0.379484931484566 0.139636769694125 0.124164224976033 2.0 -0.117084225280197 0.661209439550977 0.134391777078719 0.525483625390354 0.0173075517985215 0.946132144134679 partial_or_other True True False False False False False 2 cross_species_direction_conflict +ELAC2 -0.606836158718418 0.0447000786656694 0.389380444063995 -0.757074616874723 0.0093359907282239 0.297984207800093 0.107732858414476 1.63694444318827 2.0 -0.0527087255837049 0.918157951904821 0.263456324909079 0.423321292016099 0.210747599325374 0.575674716321094 partial_or_other False True False False False False False 2 insufficient_or_context_specific +IQCJ-SCHIP1 0.861278967435311 0.0448520135697352 0.389380444063995 0.986829771158364 0.0203297720462736 0.332725011651872 0.210131450908744 0.245435849638876 2.0 True True False False False False False 2 insufficient_or_context_specific +SNTG1 -1.25725727841261 0.0448579882935112 0.389380444063995 -1.52164767660822 0.0139109895914146 0.314756631908661 0.525710634291615 0.32464501664235 -0.982287527118842 0.042677106939985 -0.456576892827227 0.370100026705007 partial_or_other False True False False False False False 2 insufficient_or_context_specific +BABAM2 0.437846724996872 0.044896096834967 0.389380444063995 0.577181829271032 0.0047024740187341 0.261521011602645 -0.208059766870082 0.404350397279178 -0.081946003850155 0.713102437415139 -0.290005770720237 0.194262112640153 partial_or_other True True False False False False False 2 cross_species_direction_conflict +IFNGR1 0.510161051000653 0.0451411658268227 0.389380444063995 0.45736443033681 0.0749628540650649 0.452862231765951 1.02548484796118 1.0 0.204505033348117 0.457696546809139 0.216172552985998 0.33745451514702 0.420677586334115 0.0898530637373285 partial_or_other True False False False True False True 2 residual_state_candidate +KLHDC4 -0.454663867777651 0.0456881784244691 0.392494538491086 -0.610434450228741 0.0056035342046896 0.265300960238175 0.357605874316017 0.19517657308924 -0.909469656234771 0.0040237834364356 -0.551863781918754 0.0487567517059587 partial_or_other False True False False False False False 2 insufficient_or_context_specific +WBP2NL 0.693856701317208 0.0460538490222938 0.393661071168746 0.88595569493499 0.010224388788696 0.302245517751671 0.0354633160058184 1.0 True True False False False False False 2 insufficient_or_context_specific +SRP68 -0.445749286361889 0.0461595383696636 0.393661071168746 -0.48769969889567 0.0270262476175496 0.356222495883986 -0.415414567812949 0.111366789644123 0.15311222192073 0.507168535723428 -0.262302345892219 0.273219007933399 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CIC -0.748990657453397 0.0462991813283838 0.394215126181513 -0.895324310753624 0.0132783313126957 0.313114831651016 0.135891260768281 0.522176491551655 2.0 -0.0974390332846187 0.787299485057015 0.194940215229045 0.451641746207305 0.0975011819444266 0.750390797622722 partial_or_other False True False False False False False 2 insufficient_or_context_specific +COL6A1 -0.475561723337421 0.0466147172970906 0.395461683418996 -0.58314878515792 0.0105359350604431 0.302245517751671 0.6655572799611321 1.0 0.253269015937749 0.42104228941531 -0.0215048962735796 0.944684744864481 0.231764119664169 0.409548955957634 partial_or_other False True False False False False False 2 insufficient_or_context_specific +CHD4 -0.626933304190986 0.0467541809526896 0.395461683418996 -0.622844379868107 0.0484609305519827 0.403191887129892 0.139028070002079 0.6397821051278579 2.0 0.272783442447927 0.260974579751627 -0.626369923542455 0.011706710541436 -0.353586481094528 0.120257271517589 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PPIL2 -0.444865150413174 0.0469331884706159 0.396099603415478 -0.533454032825352 0.0144944199351274 0.317541556275699 0.0704069412099566 0.830525370676567 0.124248475537063 0.592920559221651 0.194655416747019 0.430056822052887 partial_or_other False True False False False False False 2 insufficient_or_context_specific +NDUFV1 -0.641492756656591 0.047383320584047 0.396574544678809 -0.790775515462155 0.0112624477999704 0.302570357129259 0.800634031869474 1.0 -0.110759400594813 0.829095915017891 0.597774870743368 0.108069940374835 0.487015470148556 0.203876214873397 partial_or_other False True False False False False False 2 insufficient_or_context_specific +PBX2 -0.442169627847705 0.04742007822847 0.396574544678809 -0.531731865582998 0.0155614552773413 0.320853404849916 -0.0062490442278528 0.987103209694911 -0.415842334183089 0.102234291175216 -0.422091378410942 0.116878374868812 partial_or_other False True False False False False False 2 insufficient_or_context_specific +FADS2 -0.53251040702705 0.0474925417970265 0.396574544678809 -0.623795785758959 0.0195157827545137 0.330467462546779 -0.0282496359568332 0.950633272242692 0.535590003688812 0.0912910605746787 0.507340367731978 0.122466799426199 partial_or_other False True False False False False False 2 insufficient_or_context_specific +HSD17B2 -1.01865397379041 0.04755064274163 0.396574544678809 -1.03724709724793 0.043463587102202 0.392214551124798 -1.49875213153233 0.00463028729414 2.14554608897532 0.0009226106283564 0.646793957442985 0.113718054790355 reversed False True False False False False False 2 insufficient_or_context_specific +TMEM255B -0.886535662471353 0.047552886300755 0.396574544678809 -1.01580157153875 0.0189817819713918 0.330467462546779 False True False False False False False 2 insufficient_or_context_specific +VAV2 -0.620349548753064 0.0480181068774041 0.396735650076082 -0.578261200288086 0.0686878688116919 0.438721427050117 -0.62749249553688 0.0563643178264037 -0.164233142002358 0.572953162219643 -0.791725637539238 0.0207391979580159 persistent False False False False False True False 2 insufficient_or_context_specific +PCSK9 -1.56759539635688 0.048266550494952 0.396735650076082 -1.82415528702815 0.0176535457937398 0.326204572615871 0.628162051111513 0.293410099944168 -0.966801633058299 0.0695507254345332 -0.338639581946786 0.561446972803569 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SULF1 1.07036930701459 0.048334135563068 0.396735650076082 1.32003901889 0.0132240109346578 0.313114831651016 0.0959838034633428 1.0 -0.902024790136343 0.0528991511989389 0.501174860925815 0.208629316418549 -0.400849929210528 0.332670203724069 reversed True True False False False False False 2 cross_species_direction_conflict +COL4A3BP 0.424404225964072 0.0483634321273754 0.396735650076082 0.469910365009047 0.0276774285960776 0.361656300887855 0.0857458686616108 0.0893596135141217 2.0 -0.204544672902353 0.38801874887668 -0.259940864633369 0.199364508619431 -0.464485537535722 0.0423588637368009 partial_or_other True True False False False False False 2 cross_species_direction_conflict +RXRB -0.720341901480518 0.0485184118107888 0.396735650076082 -0.844850191537083 0.0174244159227268 0.326204572615871 0.0148853681307421 0.963608899578971 -0.213701065275608 0.337323298274376 -0.198815697144866 0.403315594089091 partial_or_other False True False False False False False 2 insufficient_or_context_specific +MT-ND1 -0.478225462396952 0.0485492005965427 0.396735650076082 -0.573343169904023 0.0160573286465926 0.322306608081226 -0.593422279216315 0.320393267606486 0.426780285171783 0.413925686299827 -0.166641994044532 0.781363495926339 partial_or_other False True False False False False False 2 insufficient_or_context_specific +SEMA4B -0.44743199673743 0.0486106372292638 0.39693047785504 -0.54278349056126 0.0127649211406411 0.313114831651016 -0.218703969453567 0.546443183042633 0.239445267881691 0.413907229381968 0.0207412984281241 0.954635233675125 partial_or_other False True False False False False False 2 insufficient_or_context_specific +NEDD4L 0.874999816600404 0.0487241126247843 0.397242610882219 0.709447243675333 0.111793836983123 0.490094278471416 1.43618981908636 1.0 -0.843249044138087 0.0176184552661433 0.306660099738225 0.293485298780139 -0.536588944399862 0.0869800467584382 persistent True False False False False True False 2 cross_species_direction_conflict +ANAPC7 -0.388770403873655 0.0489565589838671 0.398215215525169 -0.390325360601928 0.0476509246444464 0.401835832584717 0.0984257548677886 0.785245140196288 0.174294512049223 0.505949136749098 0.272720266917011 0.3314864746361 partial_or_other False True False False False False False 2 insufficient_or_context_specific +ATP11B 0.331196727452366 0.0493362344713665 0.399082619839385 0.3983388383534 0.0155386441487138 0.320853404849916 -0.268086174157297 0.328192896573376 -0.0733835504011162 0.771742647336334 -0.341469724558413 0.17394769299212 partial_or_other True True False False False False False 2 cross_species_direction_conflict +SCP2 -0.797524682565837 0.0493871204139317 0.399082619839385 -0.825883019989849 0.0411569031361682 0.388324024407206 1.37310143639764 1.0 -1.40989295335124 0.0142901158508512 1.12618015991768 0.0293858043039421 -0.283712793433564 0.573565177142881 reversed False True False False False False False 2 insufficient_or_context_specific +THSD7B 1.54544030812627 0.0494774650876354 0.399082619839385 1.74713522674854 0.0270591439381471 0.356222495883986 1.13873354715339 0.27184979939777 0.151509820507006 3.0 True True False False False False False 2 insufficient_or_context_specific +TNFAIP3 0.981201593451034 0.0495483721669045 0.399082619839385 0.785540106277012 0.113890484498533 0.4924007041452 0.0571115316004627 1.0 -2.87692567548962 0.0130006589611637 0.177247439499504 0.884689701975116 -2.69967823599012 0.0174071293166494 persistent True False False False False True False 2 cross_species_direction_conflict +CAPN15 -0.628256369064551 0.0496389164982729 0.399082619839385 -0.747407529366313 0.0167838685562209 0.326051886437644 -0.322849164570794 0.196782141748784 -0.588437055587849 0.0192460843348778 -0.911286220158644 0.0042434523687486 partial_or_other False True False False False False False 2 insufficient_or_context_specific +RPL41 0.542519194915523 0.0498940695583038 0.399082619839385 0.64582798326598 0.0179973512014309 0.32629129734252 True True False False False False False 2 insufficient_or_context_specific +NFIL3 0.965152698818541 0.0502078454970867 0.399082619839385 0.421080701802914 0.409211654291659 0.734857324041122 0.5103881845588679 0.579588929147861 0.0255458326632082 3.0 -1.56297847463983 0.0017622408505972 0.19082993981364 0.602283219755158 -1.37214853482619 0.0050306988493698 persistent True False False False False True False 2 cross_species_direction_conflict +UQCRC2 0.387863393589847 0.0506361573761463 0.400194727078426 0.533466047539028 0.0032879354846965 0.237767279776889 0.0509199155990591 1.0 0.191977442265312 0.719214521019672 1.31633714086014 0.0070628553585345 1.50831458312546 0.0064313841695078 partial_or_other True False False False True False True 2 residual_state_candidate +TMEM50A 0.452451472673402 0.050935932689069 0.400440346479357 0.366447964334797 0.117007171649793 0.496449831511094 0.259026767927372 0.539006120426731 0.386266691206466 0.253131757655169 0.645293459133838 0.0836734839162125 partial_or_other True False False False True False True 2 residual_state_candidate +PFKFB1 -1.43569176150508 0.0511837920414324 0.401134171693403 -1.54811860037081 0.0341290978017249 0.376543096535729 -0.803328135615689 0.0698349278948489 0.0541634561494522 0.904879342928437 -0.749164679466237 0.0756530821443945 persistent False False False False False True False 2 insufficient_or_context_specific +LPAR1 0.698093782686294 0.0528435209201278 0.406035451125819 0.346993569254989 0.357810533356157 0.701288497271586 0.522088775964678 1.32589533524926 0.301346873307974 0.112426698455384 4.0 0.596354377313991 0.361674854084347 -0.194546269114241 0.718192135559082 0.401808108199749 0.511074791873394 partial_or_other True False False True False False True 2 insufficient_or_context_specific +ACOT13 0.566047050633477 0.0535471928069757 0.407607254258146 0.208627753296798 0.473903799591151 0.776334571929151 0.0293713193839411 1.0 0.427411317433095 0.255813094242579 0.72130991072127 0.0303215400480226 1.14872122815437 0.0074966190560345 partial_or_other True False False False True False True 2 residual_state_candidate +ATP8B1 0.646786717687649 0.054236464575229 0.408770140133979 0.888219816084681 0.0059906128720852 0.268003774167272 1.01527057185066 1.28304672934051 0.165889704920214 0.134093391814797 4.0 0.526441047934145 0.165629044615519 -0.414004481062277 0.202928745102028 0.112436566871868 0.774204122542806 partial_or_other True False False True False False True 2 insufficient_or_context_specific +CBLB 0.567191651011791 0.0554198394456732 0.412850293225423 0.59067236244186 0.0448287844560353 0.393650849907072 0.661172014361729 1.46408120015006 0.151157663403494 0.186286944634515 4.0 0.0223655953487837 0.966145399025796 -0.374897055300914 0.295845805291421 -0.352531459952131 0.358644201127861 partial_or_other True False False True False False True 2 insufficient_or_context_specific +SYVN1 -0.589218780888501 0.0555093296572891 0.413014448570584 -0.441388959059723 0.156075479223324 0.539558215777 -1.2989301834356 0.0124390230859606 0.487205368785001 0.245695682467001 -0.811724814650603 0.0744382636698862 persistent False False False False False True False 2 insufficient_or_context_specific +CD47 0.425220000052017 0.0589520062620976 0.41883004625994 0.451170835105928 0.0443881182849293 0.393650849907072 0.0382193875598489 0.917098540731119 0.470156744677823 0.0659468285415223 0.508376132237672 0.0609943574122193 partial_or_other True False False False True False True 2 residual_state_candidate +PTPN3 -0.719791245840173 0.0616319310571781 0.421963941037269 -0.646432231834314 0.093798898050279 0.473887234600338 -0.805754161115707 0.006477232236842 0.281143471879612 0.219394460184114 -0.524610689236095 0.0407054851113108 persistent False False False False False True False 2 insufficient_or_context_specific +NRP1 0.504022816019816 0.062444904893745 0.423438218283982 0.613690676453195 0.0207894643746897 0.333389311130767 0.3382544565278239 0.109991322625307 2.0 0.0657026610705282 0.81310596327621 0.579464723844493 0.011158316994355 0.645167384915021 0.0109886815635963 partial_or_other True False False False True False True 2 residual_state_candidate +PRPSAP2 -0.293598274435103 0.0642584364526551 0.427141335976443 -0.202430410530218 0.201354139726288 0.576216193866676 -0.687746159955576 0.0982306692466134 0.0318747623216977 0.94005956267517 -0.655871397633879 0.0948428153008631 persistent False False False False False True False 2 insufficient_or_context_specific +ATP11A -0.54320102887731 0.0669084977070933 0.432431468698827 -0.503850998301675 0.0918722190054746 0.472460751419842 0.338895424152811 1.0 -0.668704086794194 0.0240910308632568 -0.200967598812306 0.423118529826509 -0.8696716856065 0.008154497343468 persistent False False False False False True False 2 insufficient_or_context_specific +AUTS2 0.379798651422253 0.0675238536205644 0.432857830313248 0.231196608192172 0.27898336143816 0.642114507827558 -0.743314907182846 0.0674209734718208 -0.420577187725451 0.240979935177615 -1.1638920949083 0.0112199919427195 persistent True False False False False True False 2 cross_species_direction_conflict +HEPH 0.474177731246677 0.0685565869792821 0.43446260179429 0.240447321284386 0.357558861864256 0.701288497271586 0.678274549072587 0.23629065759795 0.604586238818213 0.140542137404908 1.2828607878908 0.0239223574339853 partial_or_other True False False False True False True 2 residual_state_candidate +MEF2A 0.330238132896616 0.0687169570646543 0.43446260179429 0.362644748575745 0.0430696095187262 0.391483132487066 0.5234590784012211 1.86999817217682 0.0846037240488354 0.192706416892101 4.0 0.0997844483260607 0.760055435002809 -0.123947564536421 0.620282248564212 -0.0241631162103606 0.936692237482646 partial_or_other True False False True False False True 2 insufficient_or_context_specific +COL5A3 -0.544176004396921 0.0690732579242742 0.43446260179429 -0.323419007146336 0.32066014157136 0.672472248121257 0.4898132367216729 1.0 -0.913794969436205 0.0116352756842547 0.0989764260498361 0.75260995787036 -0.814818543386369 0.0204981380874593 persistent False False False False False True False 2 insufficient_or_context_specific +CHST11 0.772576595647652 0.0694975206747905 0.43446260179429 0.920692970067595 0.0291591340424423 0.369532280957458 0.373121432029921 0.510701399645122 0.432701018781855 0.257194162604111 4.0 1.5880949600643 0.0862969221104843 -0.708741177964341 0.27203325717718 0.879353782099956 0.332962256268016 partial_or_other True False False True False False True 2 insufficient_or_context_specific +TNS1 0.431945297077812 0.0696481191095006 0.43446260179429 0.275821358563873 0.230435810299595 0.601518427890281 0.542796282427345 0.909505012053673 0.317322636873677 0.177681468117102 4.0 0.169441216682692 0.719214521019672 0.138244705228482 0.718192135559082 0.307685921911174 0.423104337579302 partial_or_other True False False True False False True 2 insufficient_or_context_specific +PRPS2 0.4267573189442 0.0711875467061732 0.437229853475147 0.315901832444193 0.196853193354828 0.571879675616801 0.808471871400615 0.255804497666675 0.333791553361891 0.504073306480859 1.14226342476251 0.0815825919207785 partial_or_other True False False False True False True 2 residual_state_candidate +PHF1 -0.468023686188521 0.0721405181695946 0.440272112487634 -0.421014000048699 0.107630128850183 0.483778821536355 0.288094499819843 1.0 -0.628348900282592 0.0350420623048047 -0.630453096815633 0.0269338924559715 -1.25880199709822 0.0024201480685987 persistent False False False False False True False 2 insufficient_or_context_specific +B3GAT3 -0.650506841773017 0.0726872426826908 0.440815469224225 -0.847309296639568 0.0152368531619053 0.320500116612027 0.327569565224546 1.0 -0.612018371605631 0.0172431284881209 -0.0742348861849569 0.743465048675792 -0.686253257790588 0.0112304993030495 persistent False False False False False True False 2 insufficient_or_context_specific +ABCC6 -1.08321905380497 0.0729027210489608 0.440815469224225 -1.01452036792521 0.0944730985057773 0.474522823037106 0.4469210194056121 1.0 -1.51170879275346 0.0025660399388253 0.60961642550046 0.101139942895551 -0.902092367253003 0.0297186931445137 persistent False False False False False True False 2 insufficient_or_context_specific +MEGF6 0.54408531641407 0.0729494305848015 0.440815469224225 0.514784879674964 0.0912256522165659 0.472234212482528 0.259930802929312 0.108538907281668 2.0 -1.4372484672177 0.0269280129150225 0.10840192429573 0.864849966799431 -1.32884654292197 0.0328447699088656 persistent True False False False False True False 2 cross_species_direction_conflict +MICALL1 -0.583337907514294 0.0729821405762404 0.440815469224225 -0.571993306889111 0.079588100200254 0.459160525051927 1.47916026742072 1.0 -0.641584128420385 0.0286735937445211 -0.10857650946483 0.676378977227839 -0.750160637885214 0.01519228421204 persistent False False False False False True False 2 insufficient_or_context_specific +FAM8A1 0.517620271986388 0.0736109997637638 0.442588232064817 0.48221512835688 0.0972967273585967 0.478125555523304 0.0113381947320599 1.0 0.0812040671229428 0.816470928889694 0.564134391291197 0.0331739034770925 0.64533845841414 0.0273470192422509 partial_or_other True False False False True False True 2 residual_state_candidate +WNT2B 0.583641161257549 0.0745994629640309 0.445739179385534 0.762834793726281 0.0161464402658173 0.322969015815994 1.08507099203707 0.137899911208203 1.3882726379708 0.0122565108424775 2.47334363000787 0.003720919926498 partial_or_other True False False False True False True 2 residual_state_candidate +COL4A1 0.891495083918503 0.0752125112177551 0.44687320958754 0.606621567240153 0.239196004557775 0.606713331305531 0.382405719399584 0.6219619125639929 0.405829365759996 0.344401211314074 4.0 1.29870853882477 0.0060801892573067 -1.28125379003536 0.0058359913855281 0.0174547487894107 0.969955408199307 reversed True False False True False False True 2 insufficient_or_context_specific +OS9 -0.291237263337122 0.0755039380427766 0.447232187228035 -0.318466006279422 0.0490796677766018 0.404177169779245 -0.704570183433022 0.0338582649823517 0.152662327412029 0.600985336426703 -0.551907856020993 0.0730215897304751 persistent False False False False False True False 2 insufficient_or_context_specific +ESR1 -0.693561189875067 0.0756202232275067 0.447281970216255 -0.23345313535477 0.558933981562572 0.821668752065948 1.03790855450457 1.2935988059121 2.0 -0.739473415539603 0.009318311249177 0.20581636320606 0.362568393658862 -0.533657052333543 0.036634198569422 persistent False False False False False True False 2 insufficient_or_context_specific +N4BP2L2 0.275164947854159 0.0761755370540361 0.449057130215809 0.223298470835669 0.156407931102176 0.539558215777 0.0723309693970668 0.109108203248883 2.0 0.235001490772796 0.35173162942836 0.320393672051828 0.135229626640712 0.555395162824624 0.0279405435141411 partial_or_other True False False False True False True 2 residual_state_candidate +LYPLAL1 0.398834183921594 0.0769596829162827 0.449901704605287 0.437634172485815 0.0502267305629564 0.405592093535716 0.0683194030360337 0.0313663545172201 2.0 0.373337864499786 0.473897760585375 0.660123491628606 0.0843666106969062 1.03346135612839 0.031164384562845 partial_or_other True False False False True False True 2 residual_state_candidate +EBF1 0.750707286674578 0.0776052725152087 0.451687681943918 0.79735704527779 0.0598546808708753 0.428473540531152 0.8500872890275369 1.13255409513548 0.343994635859731 0.125493218231284 4.0 0.169195739845865 0.899798253552411 -0.530863851495809 0.53846665770048 -0.361668111649944 0.747504020879527 partial_or_other True False False True False False True 2 insufficient_or_context_specific +H3F3B 0.554641927600826 0.0784141179581908 0.452608944744489 0.297711610971668 0.346298610530464 0.691418443642329 0.6075735230427359 1.0 0.0889218901828542 0.895560263778032 1.17868620747904 0.0182216376222349 1.26760809766189 0.0206382943196543 partial_or_other True False False False True False True 2 residual_state_candidate +UBE2D3 0.301852971892301 0.0786121095823295 0.452802320223805 0.242808714878741 0.161719497529416 0.543541307772207 0.132031190481311 0.0938443793470276 2.0 0.184754369680622 0.736323378290378 0.553193487040775 0.140755260131223 0.737947856721397 0.0916759135874971 partial_or_other True False False False True False True 2 residual_state_candidate +ELN 0.662548603240678 0.0790524730444327 0.452986618787476 0.862532009788249 0.0230812212290499 0.346051520554005 0.284661708043656 0.363977470246001 0.475740984522183 0.27790846346113 4.0 1.21980810000372 0.02538837282992 -1.26356433363261 0.0163366356976684 -0.0437562336288928 0.938029623806871 reversed True False False True False False True 2 insufficient_or_context_specific +TM9SF3 0.344216179768355 0.0798932615663698 0.453745592048269 0.348387352122277 0.0760364729386748 0.454582718735293 0.0963110919432756 0.781296035897642 0.455605614158129 0.0826656210790024 0.551916706101405 0.0529530336923563 partial_or_other True False False False True False True 2 residual_state_candidate +ARL5B 0.699087528103672 0.080527787049219 0.454902287675577 0.976571451531549 0.0137543826759938 0.314756631908661 0.256292832869019 0.497432374295653 0.294959417710975 0.305669831296726 0.551252250579993 0.096795567133677 partial_or_other True False False False True False True 2 residual_state_candidate +RPAIN 0.379550549931581 0.0826479517770522 0.458585841408647 0.157416760646458 0.483951491399305 0.780666906162311 -0.573434631747097 0.0181389663940921 -0.273715648065858 0.178195365415469 -0.847150279812954 0.0038741220603223 persistent True False False False False True False 2 cross_species_direction_conflict +CST3 0.638578763674248 0.0826870548965152 0.458585841408647 0.650849525064132 0.0772731929769247 0.455668688469891 0.625397927260668 0.0594550900613734 2.0 0.463665549667161 0.213057867168313 0.695169032575945 0.047270610468829 1.15883458224311 0.0077944610695242 partial_or_other True False False False True False True 2 residual_state_candidate +RARB 0.736116902721212 0.0827377256463888 0.458585841408647 0.388208184435612 0.36339689122368 0.704765682869143 0.6310759480352359 0.7618712763663341 0.0038396382153385 0.0941477301204401 4.0 0.810484140605621 0.0177779127445313 -0.990335869306311 0.005309342657281 -0.17985172870069 0.565242424926909 reversed True False False True False False True 2 insufficient_or_context_specific +BNC2 0.610724224893104 0.0832110221960602 0.459037065463974 0.595472237312142 0.0919637732719326 0.472460751419842 0.93203507822809 0.250588347590269 0.116995885352041 3.0 -1.07456298531478 0.0959807146774546 -0.0652079888539647 0.924022101894769 -1.13977097416874 0.0678132728164929 persistent True False False False False True False 2 cross_species_direction_conflict +HDGFL3 0.414664726045511 0.0844123945473779 0.460216624403445 0.516206511521922 0.0295975957590718 0.371414855918995 0.0508279176045518 1.0 -0.710433854199258 0.0609988504677506 0.0026643658218949 0.995526255238165 -0.707769488377363 0.0522638920638359 persistent True False False False False True False 2 cross_species_direction_conflict +PPP2R5A 0.308485400465949 0.0847897045550817 0.460262056911338 0.164504732929412 0.358958684616618 0.702481147763162 0.0708548064861117 0.877799403032967 1.06974692565997 0.005936567007941 1.14060173214608 0.0071915727806432 partial_or_other True False False False True False True 2 residual_state_candidate +PRKAR1A 0.282017389481552 0.0859907434663262 0.463815671176355 0.15153364051188 0.36272464844416 0.704473895481459 0.7230257969485792 0.4371625008693039 2.0 0.209278966992111 0.390486229760679 0.180965691899415 0.380345328313157 0.390244658891526 0.0833778130497341 partial_or_other True False False False True False True 2 residual_state_candidate +PRAG1 0.786266522600262 0.0860593767602273 0.463815671176355 1.04133424147285 0.0285751791994592 0.367474716185007 0.7952285789268091 1.0 3.14819556006002 0.0001059028211405 -2.18485379682168 0.0007393067998235 0.963341763238337 0.0784495441570327 reversed True False False False True False True 2 residual_state_candidate +PRDX1 0.494322109096811 0.0862656167039764 0.464095198907497 0.342170130684824 0.231484476575168 0.601518427890281 0.193188276416893 0.599679560794611 0.979135412515521 0.0070995430580289 1.17232368893241 0.0049974039783899 partial_or_other True False False False True False True 2 residual_state_candidate +CEP68 0.407084397399839 0.086628666668174 0.464748710712694 0.311302040170419 0.184214255611211 0.565716727964854 0.408588818228693 0.220638627693788 0.130932840160062 0.648804791198865 0.539521658388756 0.087109491740883 partial_or_other True False False False True False True 2 residual_state_candidate +COPA 0.305251988658602 0.0874038815989734 0.46650493983352 0.355055771170558 0.0444552507092448 0.393650849907072 0.0754857300110481 0.0644874972857902 2.0 0.226971532410639 0.474389756379283 0.284152673233158 0.278942829713858 0.511124205643797 0.0761110811469107 partial_or_other True False False False True False True 2 residual_state_candidate +GBP2 0.749572143449409 0.0878786877022657 0.467417221541824 0.454145207239387 0.320683657197708 0.672472248121257 1.47780326224229 0.0663740678065904 2.0 -1.85557138583067 0.0240983433879915 0.311959419177855 0.669657839993789 -1.54361196665281 0.0425665157431516 persistent True False False False False True False 2 cross_species_direction_conflict +NPC2 0.823477576593892 0.0880140269642117 0.467665876541594 1.08626900860228 0.0251781336646425 0.351006805738558 0.0384104068933706 1.0 0.316304075320122 0.268445622372792 0.309114796555289 0.206633324845706 0.625418871875411 0.0298946023773738 partial_or_other True False False False True False True 2 residual_state_candidate +QSER1 0.320885015680572 0.0881497942656209 0.467916303598002 0.16458709418231 0.385777276491002 0.720039941378048 0.0597664352196748 1.0 0.532140925337432 0.272248823160214 0.216332562753912 0.56101181686048 0.748473488091344 0.0948161726757493 partial_or_other True False False False True False True 2 residual_state_candidate +CGN -0.905267397764672 0.088246080015008 0.468192016481635 -1.16108405139325 0.0246120807414844 0.349408136686844 -0.858585753176825 0.0048246714597431 0.0809647918174488 0.744639701289962 -0.777620961359376 0.0094902323945825 persistent False False False False False True False 2 insufficient_or_context_specific +CCDC84 -0.410124931703576 0.0885524562995678 0.468615222083178 -0.239872018109913 0.34145210217125 0.689048585850067 0.424234696932037 1.0 -0.723917403477059 0.023272818646044 -0.124474057815538 0.657151096070358 -0.848391461292596 0.0124406245839615 persistent False False False False False True False 2 insufficient_or_context_specific +RNF11 0.493683405779103 0.0892935884474792 0.469970940592466 0.480990578708626 0.0984835588227521 0.478125555523304 0.986429457429688 0.0954033966608206 2.0 0.212269376331242 0.530531299102969 0.556451914007086 0.0519979268681754 0.768721290338328 0.0206212459289334 partial_or_other True False False False True False True 2 residual_state_candidate +ADAMTSL4 -0.816901010012449 0.0907472907629804 0.47312329130067 -0.998745317579413 0.0320066553610183 0.375031405408838 0.4217482609189749 1.0 -1.25210006364999 0.0097274209644883 0.255922661267255 0.514506030609491 -0.996177402382738 0.0267794004284863 persistent False False False False False True False 2 insufficient_or_context_specific +MSN 0.6229348492754 0.0908153716948485 0.47312329130067 0.708547452348594 0.0514467664387935 0.410669094118466 0.426800326431553 0.0868287968531056 0.170575633249223 3.0 0.362165795661747 0.272505927607051 0.169564390118632 0.560189271646654 0.531730185780379 0.0870656032544512 partial_or_other True False False False True False True 2 residual_state_candidate +PECAM1 0.745696238575638 0.0910767943890761 0.47312329130067 0.546336408029813 0.209158817532892 0.581590412302417 0.6432669754813629 1.0 0.588251259172059 0.123021345733282 0.222128812044035 0.487244053647066 0.810380071216094 0.0336886445150656 partial_or_other True False False False True False True 2 residual_state_candidate +SEMA4A -1.15738486188292 0.0937069377162935 0.476750142624258 -1.28464792684506 0.0599408429024921 0.428473540531152 -0.649933517875311 0.0390117104032097 0.132384723357635 0.635034635945701 -0.517548794517676 0.0767293776489396 persistent False False False False False True False 2 insufficient_or_context_specific +C7 0.740686145374581 0.095051886088279 0.479258078302265 0.580533862423252 0.189597695868662 0.569886897607216 0.655044788749447 0.350293172339096 2.0 0.58027933497725 0.425862479107702 1.86030576937025 0.0040890753464704 2.4405851043475 0.0035440769053387 partial_or_other True False False False True False True 2 residual_state_candidate +SLC12A7 -0.55777300417585 0.0956778690329678 0.479258078302265 -0.434001498634992 0.20684793285202 0.579899223327571 1.02402613024621 1.0 -1.2305153858678 0.001965696939265 0.61510354468092 0.0420192962565403 -0.615411841186881 0.0464630939114413 persistent False False False False False True False 2 insufficient_or_context_specific +CHIC1 0.372405705880856 0.0962402234115068 0.480151093364473 0.344470906313554 0.126315652255083 0.508384607335028 -0.717890736830954 0.0735675907680753 -0.194262933367651 0.592920559221651 -0.912153670198605 0.0281053191861669 persistent True False False False False True False 2 cross_species_direction_conflict +DOCK5 0.373057293395717 0.0965240079960629 0.480151093364473 0.153019784140356 0.49817891716506 0.789518614144207 1.23126486331027 1.0 -0.756655718915759 0.0248257479435756 0.163863446486578 0.565896080299188 -0.592792272429181 0.0556752012051446 persistent True False False False False True False 2 cross_species_direction_conflict +PCMTD1 0.339105258866165 0.099596763529137 0.484805269405546 0.221822603227029 0.288052152721566 0.648258530618693 0.380091858217337 0.1821383066007 0.258347288271508 0.283105821907691 0.638439146488844 0.0281804992424668 partial_or_other True False False False True False True 2 residual_state_candidate +FARS2 0.318349455671423 0.100653419928266 0.486389058212075 0.264780266056671 0.178457201505022 0.561427632148399 0.662401092207729 1.0 -0.557122419301898 0.0424178927269605 -0.229742925274381 0.330057463759696 -0.786865344576279 0.0100390592108919 persistent True False False False False True False 2 cross_species_direction_conflict +PEX2 0.462740898760271 0.101343826203683 0.488073489121063 0.570644819405704 0.0433374374644825 0.39207940424165 0.0397731224889272 1.0 0.029448734854312 0.937645642113398 0.489139164454319 0.0611056258646055 0.518587899308631 0.0629660052504326 partial_or_other True False False False True False True 2 residual_state_candidate +MERTK 1.03920808340094 0.10265126711982 0.488987220408302 -0.277200898609135 0.646594746450658 0.868101135939223 0.4922122474588039 0.3998920033032349 0.1782947963577 0.0369496704621274 4.0 0.297407392756663 0.448318253371762 0.626241207576332 0.0619234127648967 0.923648600332996 0.0199011974310678 partial_or_other False False False True True False False 2 insufficient_or_context_specific +FNDC4 -0.862585235227358 0.105210661800411 0.491938900073281 -0.754036605702133 0.163217453717655 0.544298760692042 0.507087617304123 1.0 -1.04970655044906 0.0022034593158533 0.306880601319757 0.212496910390368 -0.7428259491293 0.0143365398002038 persistent False False False False False True False 2 insufficient_or_context_specific +SERPINA10 -0.637456246392869 0.105887697821666 0.493229418042079 -0.409092331141663 0.311901663168183 0.664337047357073 -1.49130213501661 0.0030551538304764 0.501156365808851 0.1754078825185 -0.990145769207759 0.0226691201383993 persistent False False False False False True False 2 insufficient_or_context_specific +PCGF5 0.317662402324524 0.10968506608972 0.500271205737744 0.286876645294522 0.151020474859725 0.533690850143514 0.399544044201163 0.276880245780029 0.182408929115814 0.141546724810808 4.0 0.0385079297682107 0.945771141117588 -0.307750534202841 0.408833110465704 -0.26924260443463 0.512644440056408 partial_or_other True False False True False False True 2 insufficient_or_context_specific +ADCK1 -0.507005677023598 0.110050785146949 0.50036681364622 -0.497040883996577 0.117585782641591 0.497239639401058 -0.585158568015682 0.0281376271196803 -0.0418858970807134 0.869937572542554 -0.627044465096395 0.0206382943196543 persistent False False False False False True False 2 insufficient_or_context_specific +UQCRQ 0.575507736822768 0.113959072023393 0.505495336947715 0.801477619232724 0.030772041247277 0.375031405408838 0.0535238896759231 0.924735721302228 1.3071786547778 0.0057712376246471 1.36070254445372 0.007411374517225 partial_or_other True False False False True False True 2 residual_state_candidate +IMMP2L 0.333169893639216 0.11425924550227 0.506018923663156 0.389465357944246 0.0609893471576957 0.429268745755419 0.196626470224861 0.1759629857884 2.0 -1.26869111386779 0.0012569853727434 0.575139610738009 0.0463441110569953 -0.693551503129778 0.0264445429962024 persistent True False False False False True False 2 cross_species_direction_conflict +CCDC85C -0.619141236457722 0.115616761085069 0.507588519560785 -0.554930296216979 0.163112593489159 0.544298760692042 -0.644640508921123 0.0279759098485379 -0.262731669678342 0.291047191403322 -0.907372178599465 0.006838687868164 persistent False False False False False True False 2 insufficient_or_context_specific +GMEB2 -0.436408610761809 0.116653240326168 0.508475415992879 -0.582719312741631 0.0329722288955702 0.375130164525249 0.7094734770243101 1.0 -0.615930650369716 0.0948378938477413 -0.597425501357587 0.0804800741768752 -1.2133561517273 0.0067677687323908 persistent False False False False False True False 2 insufficient_or_context_specific +CDKN1C 0.899701770735144 0.116981131411887 0.508475415992879 0.353029588655039 0.491809579064626 0.785674918408885 0.80850585067109 0.286084384898412 0.427104136706423 0.429743568591913 1.23560998737751 0.0766962006359264 partial_or_other True False False False True False True 2 residual_state_candidate +PDE6D 0.274779547306556 0.117067944791353 0.508571516736233 0.320103138294979 0.0631888787005275 0.432999502601999 0.399891155994403 0.340641074387507 0.249038279569295 0.446933228394402 0.648929435563698 0.0922679441391236 partial_or_other True False False False True False True 2 residual_state_candidate +ITPK1 -0.372388125626492 0.117889178897404 0.509172485612679 -0.426611736561632 0.0657967790608216 0.435810786276132 -0.876653662426838 0.0150287546992305 0.0405861484871975 0.906356154719516 -0.836067513939641 0.0193743150797746 persistent False False False False False True False 2 insufficient_or_context_specific +CHKA -0.442552920342985 0.118372363750959 0.509904290690586 -0.366676170978204 0.204116689517381 0.577300832554113 0.839098708102425 1.0 -0.570761480080281 0.057146640804541 -0.617478794669001 0.0318907698878728 -1.18824027474928 0.0031776412702567 persistent False False False False False True False 2 insufficient_or_context_specific +DCN 0.539178272133714 0.118461517955737 0.509909616378058 0.641095491476352 0.0602225941631025 0.429268745755419 0.8396212717725849 0.103515631937634 2.0 0.05145385948274 0.914827918728458 1.03545342922757 0.0088771675942206 1.08690728871031 0.0098518444995876 partial_or_other True False False False True False True 2 residual_state_candidate +LY6E 0.638180873652598 0.121829374125625 0.514532640547624 0.819090115183766 0.0478603823778599 0.401952804329389 0.653074052864439 0.0207484665938763 2.0 0.294557520588999 0.377919479981629 0.81847917821928 0.0139706074944924 1.11303669880828 0.0053819116927464 partial_or_other True False False False True False True 2 residual_state_candidate +EMCN 1.03797935459864 0.122841592705045 0.516349776320899 0.906500060285348 0.176097863928716 0.558163088369673 0.579679538687796 0.427842744261142 0.507648252676904 0.297718223337449 1.0873277913647 0.0869800467584382 partial_or_other True False False False True False True 2 residual_state_candidate +ABCA3 -0.570958158414029 0.125431701683225 0.519948137562422 -0.367811882864 0.355723013756936 0.699259649831639 0.638111526845235 1.0 -0.5453926014037 0.0440096429631767 0.0652518095565189 0.7935978692796 -0.480140791847181 0.0604495210259736 persistent False False False False False True False 2 insufficient_or_context_specific +CCDC80 0.984596874201493 0.125855029618388 0.52068080043532 1.3220230015487 0.0387050442941086 0.379484931484566 0.0104627050305277 2.40467711339668 0.0797798994350586 3.0 2.35623748991734 0.0001545500117814 -1.36367355070829 0.0034695030437418 0.99256393920905 0.0187636103997346 reversed True False False False True False True 2 residual_state_candidate +PSMA3 0.357734040921749 0.126867982161157 0.522427308990342 0.502883235883669 0.0254965771450269 0.351006805738558 0.0896603141711729 1.0 0.829598798136179 0.100543576983252 1.27005820631893 0.0064548482388834 2.09965700445511 0.002288965675001 partial_or_other True False False False True False True 2 residual_state_candidate +TMCO1 0.40595770519366 0.126937704387045 0.522427308990342 0.418966197751708 0.115164350695981 0.49306780804873 0.063975709863414 1.0 0.0762753855838004 0.858677756469417 1.1974395693643 0.0026194840581572 1.2737149549481 0.0035440769053387 partial_or_other True False False False True False True 2 residual_state_candidate +YAE1D1 0.346614470228024 0.127399571464886 0.522820192778903 0.272615695864485 0.226899353652659 0.599150046792164 1.15838191005675 0.140018931204312 0.643140686923349 0.196130965826194 1.8015225969801 0.0207003041200977 partial_or_other True False False False True False True 2 residual_state_candidate +GCGR -0.822400610909604 0.132550175895474 0.532723546670884 -0.81820421078093 0.135284455748958 0.521860900181769 -1.54506193588091 0.0002976571723549 0.428243815190661 0.108926755655765 -1.11681812069025 0.003720919926498 persistent False False False False False True False 2 insufficient_or_context_specific +MSH3 -0.259495462152681 0.133034471611665 0.533451557643736 -0.212467788937307 0.221211203435537 0.592913326464062 -0.630220667876715 0.0597690506295113 -0.0174545449428133 0.958582780498268 -0.647675212819528 0.0457627550852397 persistent False False False False False True False 2 insufficient_or_context_specific +PPP5C -0.317869730161767 0.133155328783408 0.533733470499325 -0.233383452870501 0.277514308801377 0.64071639456045 1.15189321284968 1.0 -0.550317950897449 0.0260025188401845 0.142256791394106 0.495156065652892 -0.408061159503343 0.0711859241423238 persistent False False False False False True False 2 insufficient_or_context_specific +EIF1AX 0.310358731081987 0.133722268243981 0.534787768227256 0.120363798377999 0.544569107684434 0.815113627216777 0.0429063359711956 1.0 0.333578887745691 0.440740195967032 0.932267687918103 0.0106244022687197 1.26584657566379 0.0065314512951213 partial_or_other True False False False True False True 2 residual_state_candidate +GNPTAB 0.466230785506976 0.136565343633156 0.537028213712411 0.498321905164583 0.112526359077005 0.491743915204892 -1.36889957046796 0.0440837755606391 0.0556053253088106 0.936234674048899 -1.31329424515915 0.0438158720377525 persistent True False False False False True False 2 cross_species_direction_conflict +ABCG5 -0.867934185588913 0.137205949470465 0.537488043399431 -0.859145366209029 0.141806595852197 0.526995437876627 -1.4130878006844 0.008433336846783 0.445676690472176 0.293630028905344 -0.967411110212223 0.0396757426500509 persistent False False False False False True False 2 insufficient_or_context_specific +MED21 0.47939940479071 0.13748257794958 0.537488043399431 0.432670856500079 0.181505399043954 0.564332404732057 0.359136747106685 0.424102597954659 0.396812040314607 0.254503758685416 0.755948787421292 0.0654551050740384 partial_or_other True False False False True False True 2 residual_state_candidate +JAK1 0.22234530935967 0.138062789681174 0.537488043399431 0.182697754607906 0.221699003302124 0.592957341103408 0.946277578195577 1.0 0.153829107393216 0.625040275548432 0.542206314929847 0.0411675694420889 0.696035422323063 0.0206382943196543 partial_or_other True False False False True False True 2 residual_state_candidate +IL15RA 0.497224745072465 0.138188469890036 0.537580642998895 0.538776033339694 0.107853699898953 0.483943630910814 0.404066150672149 0.5350971386822471 0.0439261388157785 3.0 -1.12117353203256 0.0056665927006969 0.520732157136423 0.10233335287161 -0.600441374896139 0.0733831104658131 persistent True False False False False True False 2 cross_species_direction_conflict +PHLDB2 0.317768830977005 0.140075602613555 0.538942462388233 0.189761558129868 0.394823078037676 0.726080478554543 0.267649059337402 0.470283861248472 0.292995538569203 0.186830510460487 4.0 1.71458357804083 0.0009438114445698 -1.6885500345489 0.0013228279501821 0.0260335434919336 0.951038089726536 reversed True False False True False False True 2 insufficient_or_context_specific +SPIDR 0.266366492055062 0.140784553065613 0.538942462388233 0.24099731283549 0.183221041775848 0.565541146173142 0.230801571365035 0.8311407009060842 0.205022218664877 0.101917875464031 4.0 0.765587045689436 0.0577091094285948 -0.517964609784841 0.114823638688456 0.247622435904595 0.521048093321963 reversed True False False True False False True 2 insufficient_or_context_specific +PIGT 0.389390486805076 0.141871899475991 0.540123689645298 0.525489789230084 0.0439277404054594 0.393650849907072 0.154483816143719 0.657621361749534 0.381567012529799 0.152065264774377 0.536050828673518 0.0712156106788186 partial_or_other True False False False True False True 2 residual_state_candidate +EDEM3 0.40261298004214 0.142033508103296 0.540198047029754 0.620954693997456 0.0157410368336155 0.320853404849916 0.6796598225915961 0.375165540092682 0.0493977254979222 0.0762276138425749 4.0 0.0166554187424993 0.962850315611004 -0.094172306980002 0.712097051852911 -0.0775168882375027 0.787218373876903 partial_or_other True False False True False False True 2 insufficient_or_context_specific +ATG16L1 -0.323928577496955 0.143606533391757 0.54262288458519 -0.312933215948124 0.158866216640633 0.543060696740211 -0.616379081972111 0.0259946798413385 0.107844623090643 0.655536878818856 -0.508534458881468 0.0489026874035109 persistent False False False False False True False 2 insufficient_or_context_specific +CTIF 0.378537547252701 0.149527714307842 0.54848515087022 0.273145007099415 0.301655609317657 0.65922243713362 0.453053738673385 0.286484073758269 2.0 -0.726836966265459 0.010460058241346 0.201912605644072 0.377146670941356 -0.524924360621387 0.0403324950519967 persistent True False False False False True False 2 cross_species_direction_conflict +ECM2 0.500733462496626 0.150069937711576 0.548818289698239 0.228668649875575 0.51775668851058 0.800840369846825 0.105276843716194 1.0 0.283065677760969 0.648024117038554 1.22797522547017 0.0087443417473044 1.51104090323114 0.0090554333317058 partial_or_other True False False False True False True 2 residual_state_candidate +CSNK2A1 0.291728990332205 0.151073855549765 0.550531585105462 0.408610870558802 0.0422536575759274 0.3908928278867 0.0257418947731924 0.0544458802427062 2.0 0.414760291596255 0.148757698730074 1.11850054249931 0.0014644906802052 1.53326083409556 0.0009293818384144 partial_or_other True False False False True False True 2 residual_state_candidate +TJP3 -0.93066179915659 0.15308144496071 0.551229450649633 -0.969190326321588 0.136284247469798 0.523136620282319 -1.36755406381526 0.0021929436673822 0.150600682369815 0.658615950430401 -1.21695338144545 0.0055043335418112 persistent False False False False False True False 2 insufficient_or_context_specific +COL18A1 -0.678783567984581 0.157460627833919 0.55818180340625 -0.664339584040098 0.167622062692904 0.547623080618609 -1.40670536368698 0.004757234158408 0.685575845368215 0.0792248970102737 -0.721129518318764 0.0767117584130184 persistent False False False False False True False 2 insufficient_or_context_specific +SNX33 0.484331891117515 0.158411268872166 0.559366614298438 0.103063199481122 0.76244286259176 0.916603852905611 0.255183512395793 0.4459284975562871 2.0 0.19657608885581 0.486767112548838 0.466964312228407 0.0553091187388057 0.663540401084217 0.0194335546187869 partial_or_other True False False False True False True 2 residual_state_candidate +WIPF3 0.783393851073173 0.15974989359142 0.561378161509638 1.06529790998567 0.0569176992439192 0.424455207563489 1.02807041885807 0.728722715351277 2.0 -2.35590369491163 0.0203094780196622 -0.0732940850231487 0.948640568899408 -2.42919777993478 0.0190404544447304 persistent True False False False False True False 2 cross_species_direction_conflict +VAPA 0.264247043563343 0.161802643381545 0.563502444760982 0.367671746816966 0.0453309217511166 0.395615485084814 0.853075164488728 0.452485604306303 0.0808770131772216 0.108280939298656 4.0 0.0224082809988796 0.947463920055677 0.185935758904274 0.393864203377236 0.208344039903154 0.377975679872763 partial_or_other True False False True False False True 2 insufficient_or_context_specific +SUB1 0.246328940247209 0.162554506176863 0.56418490342384 0.260742918680921 0.136996517335652 0.523456610506354 0.7504154858229871 1.0 0.410842239935453 0.488335954733525 0.617202116333931 0.153946081173947 1.02804435626938 0.0515105137077789 partial_or_other True False False False True False True 2 residual_state_candidate +TMEM140 0.582928250123233 0.164331771033451 0.566088626929788 0.770322896238381 0.0657136246840562 0.435533238803682 0.542166931029482 0.0322664704330395 2.0 0.278339318121706 0.342720226913364 0.389185738279429 0.117457705498441 0.667525056401134 0.0247189928973452 partial_or_other True False False False True False True 2 residual_state_candidate +ADGRF5 0.824438522723201 0.164689069936853 0.566137811285775 0.351906381683035 0.543518081718211 0.814659839122782 1.03167374006506 1.0 0.0301019314443866 0.957440974715565 0.650667048166589 0.0854562626970375 0.680768979610975 0.0943939383726444 partial_or_other True False False False True False True 2 residual_state_candidate +PARP4 0.244294209721783 0.166613785233879 0.568117437794602 0.199915488492145 0.261775272899001 0.624330278962413 -0.59827362528216 0.0792059608205471 -0.253844079814967 0.399183405604824 -0.852117705097126 0.019698098475891 persistent True False False False False True False 2 cross_species_direction_conflict +CD55 0.621674209033864 0.166647064297204 0.568117437794602 0.465203203468505 0.300847832256279 0.658632920234719 0.417574179285475 1.0 -0.877854144041156 0.0634127172436913 0.0899769475137175 0.844216611863314 -0.787877196527439 0.0765101275112431 persistent True False False False False True False 2 cross_species_direction_conflict +NANS 0.431238489238501 0.168024131704032 0.569867903158102 0.292195060167818 0.36359182478404 0.704883253447919 0.140457802808352 0.689403464202542 0.573738240418357 0.0379005769458928 0.714196043226709 0.0247189928973452 partial_or_other True False False False True False True 2 residual_state_candidate +PHC2 0.324187752385058 0.170053949570533 0.571856753217971 0.25003614459001 0.290725674432667 0.650001487250975 0.720350977664843 0.644023014220927 0.15807801628591 0.123951682071314 4.0 0.279710142957688 0.307658764680924 -0.243837064393598 0.298181174204016 0.0358730785640895 0.903117914154853 partial_or_other True False False True False False True 2 insufficient_or_context_specific +FGD6 0.42421682922718 0.171011996950863 0.571856753217971 0.336556134878199 0.281294957396444 0.64315368591277 0.374831943063735 0.265861481698689 0.184568566702982 0.515791697626155 0.559400509766717 0.0784897222483681 partial_or_other True False False False True False True 2 residual_state_candidate +NCSTN 0.342234842567248 0.171642753694027 0.572046717378676 0.19355441806717 0.443805392427681 0.75955541145266 0.112410827048398 0.684618554469955 0.404479901445904 0.0654762968426826 0.516890728494302 0.0346755710417939 partial_or_other True False False False True False True 2 residual_state_candidate +RASGRF2 0.583336524236517 0.172035376964386 0.572046717378676 0.547170740861778 0.20214980158622 0.57668584531318 -2.53236255531344 0.0144271318522095 0.262324504788972 0.812730369448256 -2.27003805052447 0.0207788960191138 persistent True False False False False True False 2 cross_species_direction_conflict +AJAP1 0.759622409891243 0.172137420029916 0.572046717378676 0.284241705494618 0.56175308825237 0.823291102966203 0.9452200566320358 1.0 2.98963558242979 0.0005851996560389 -1.52408245249751 0.0054451042448924 1.46555312993229 0.0391192924005971 reversed True False False False True False True 2 residual_state_candidate +SNX9 0.201098064365974 0.172593771823674 0.572794508776989 0.231576768175324 0.112067512231814 0.49053940792296 1.21705411402233 1.01812695628572 2.0 0.293103296082178 0.214070347206186 0.0785766728363369 0.713786413799643 0.371679968918515 0.0951184141566577 partial_or_other True False False False True False True 2 residual_state_candidate +TRAM2 0.461509741861297 0.174242033141765 0.573676192501689 0.569000121713064 0.0894527960679439 0.470746198832535 0.89314276354368 0.6122705656451422 0.18495792005183 0.104190576943727 4.0 0.382991458224705 0.141130510461802 -0.420786764653922 0.068871070498288 -0.0377953064292167 0.894614076399561 partial_or_other True False False True False False True 2 insufficient_or_context_specific +EMC3 0.289599070380369 0.175759407754412 0.575222513041252 0.138758898189442 0.505138618315576 0.792832263802515 0.3724150843439989 1.0 0.00931630301386 0.981491186794154 0.973113897552557 0.0039566153281876 0.982430200566417 0.0065314512951213 partial_or_other True False False False True False True 2 residual_state_candidate +FGGY -0.369776412047877 0.179940783962981 0.580473135729219 -0.415217689099936 0.131808191950449 0.518105320406865 1.0990300190668 1.0 -1.07456218688714 0.0018856555800233 0.490347371439636 0.0574511026544237 -0.584214815447504 0.0345735970065537 persistent False False False False False True False 2 insufficient_or_context_specific +ACBD4 -0.484313574756709 0.180052129239415 0.580473135729219 -0.44679046413559 0.218156065058962 0.590436230426177 0.325020713721698 0.288235910977669 2.0 -0.552843617842444 0.021866722114149 -0.321477438912302 0.118275698589887 -0.874321056754746 0.0035532665101509 persistent False False False False False True False 2 insufficient_or_context_specific +GTF2B 0.272690456464853 0.180487178219934 0.580747619213834 0.171115979737124 0.400993160597406 0.730701724126236 0.0241829615169993 0.951364679917647 0.549101956349239 0.0419314611765061 0.573284917866239 0.0502180590957666 partial_or_other True False False False True False True 2 residual_state_candidate +COBLL1 -0.325610274589583 0.180745645414369 0.580747619213834 -0.208310374160308 0.384857007861999 0.719553796530367 -1.13169553407612 0.002224462000775 0.524146306742621 0.0596128801952108 -0.607549227333502 0.0394864888397239 persistent False False False False False True False 2 insufficient_or_context_specific +RAB12 0.302896729264753 0.180967954841212 0.580747619213834 0.260838012870423 0.249932637329804 0.61625146775527 0.0955075271822206 0.75658719898162 0.322119247441499 0.15661587564856 0.41762677462372 0.0923063271732888 partial_or_other True False False False True False True 2 residual_state_candidate +PTEN 0.338643462860133 0.187856183727978 0.586844239050912 0.270288960787641 0.291911058645919 0.651509781962399 1.4699627694391 0.115308374360134 2.0 0.368176281592143 0.172896799598784 0.397111280589234 0.0974846296733973 0.765287562181377 0.0112764981960695 partial_or_other True False False False True False True 2 residual_state_candidate +TMEM9B 0.498209238208973 0.188663515237926 0.586844239050912 0.205316157280963 0.596184247818693 0.841062705567846 0.157034575213006 0.64876414120596 0.390789996046667 0.136631611788658 0.547824571259674 0.0642543307437862 partial_or_other True False False False True False True 2 residual_state_candidate +SUMF1 0.226888062271777 0.188993474028744 0.586844239050912 0.295413777933049 0.0843462969919571 0.464779732481256 0.0798058046642334 1.0 0.247447834292771 0.574026657791651 0.518854505479403 0.123325516653487 0.766302339772174 0.0492376463060669 partial_or_other True False False False True False True 2 residual_state_candidate +KIFC2 -0.608045703747094 0.189599945610838 0.586844239050912 -0.43558790301336 0.360886772840483 0.703177809506737 -0.685674391512361 0.0806805283714422 -0.708929398323214 0.0576867476314101 -1.39460378983558 0.0051169715960861 persistent False False False False False True False 2 insufficient_or_context_specific +CNBP 0.190164384446415 0.189651122312054 0.586844239050912 0.0922843371118866 0.534052170371825 0.810537816246747 0.4223571786236041 0.0576923761523738 2.0 0.0041943551570377 0.992110993471489 0.506840890724935 0.0574511026544237 0.511035245881973 0.0689225641128056 partial_or_other True False False False True False True 2 residual_state_candidate +NEK7 0.275929910217266 0.190724057226619 0.586919294801005 0.321600384047415 0.125284810090121 0.507642816276301 0.171901415589988 0.509209338320921 0.360700633583656 0.0875308787169787 0.532602049173644 0.0304248343175407 partial_or_other True False False False True False True 2 residual_state_candidate +BRWD3 0.253976809037232 0.192989311216866 0.59120989205847 0.217498028056317 0.270720715132775 0.634747792665298 -0.577943448953008 0.0381895867019911 -0.171133615133442 0.477307079631389 -0.74907706408645 0.0131086841178374 persistent True False False False False True False 2 cross_species_direction_conflict +SAMD8 0.234873857335928 0.193032070803899 0.59120989205847 0.204590739144089 0.256319036498554 0.620976683651155 0.138714055824364 0.714873216503155 0.801102516410788 0.0108482318864971 0.939816572235152 0.010255670284984 partial_or_other True False False False True False True 2 residual_state_candidate +TMEM204 0.342848772259106 0.193433658037393 0.59196306132139 0.168305491408595 0.509359200221629 0.796241403011543 0.37008537456608 0.653008686465485 2.0 0.0040292321519301 0.992788933773383 0.948641715181553 0.005309342657281 0.952670947333483 0.0075508193403489 partial_or_other True False False False True False True 2 residual_state_candidate +TTC39C 0.382154968445556 0.193956975299423 0.592191366457868 0.458014402727239 0.1130574866918 0.4924007041452 0.153725930933391 1.0 -1.45037209974532 0.0054214743032507 0.51249402918856 0.199801682785657 -0.937878070556755 0.0369148994115098 persistent True False False False False True False 2 cross_species_direction_conflict +ARL8B 0.271775601381649 0.194494283726604 0.592331237446358 0.233515496492607 0.27008059002782 0.634515102250495 1.23766788475534 1.0 0.0582209380877457 0.888246105077982 0.640595585750392 0.0330160335361673 0.698816523838138 0.0319522317282264 partial_or_other True False False False True False True 2 residual_state_candidate +PRKCZ -0.714582780303018 0.200120902682321 0.599870077043346 -0.835338115673709 0.12639088563996 0.508384607335028 0.250198504459281 1.0 -0.935652033053229 0.0335587687300548 0.282860720045433 0.448107854059192 -0.652791313007797 0.0983673131606706 persistent False False False False False True False 2 insufficient_or_context_specific +ITFG1 0.209687425665578 0.202566826151072 0.602883734490867 0.271319337224488 0.0887731127838516 0.469932751718496 0.162492957334904 0.506378482475533 0.377531552436491 0.063925160738776 0.540024509771395 0.023257696200555 partial_or_other True False False False True False True 2 residual_state_candidate +PSMD5 0.273071093929203 0.204407452615086 0.604855708155356 0.0587377315364547 0.786701277796985 0.926121604088118 0.532812722866949 0.125504765715144 0.840043023524225 0.0087138668410365 1.37285574639117 0.0026543516104131 partial_or_other True False False False True False True 2 residual_state_candidate +MTPN 0.3108802709438 0.207397136678129 0.606869006043246 0.300404350691445 0.222501270497007 0.593397884800048 0.131519397724856 0.799430757596096 0.687631456403859 0.064164001723113 0.819150854128715 0.0480316515174267 partial_or_other True False False False True False True 2 residual_state_candidate +PLS3 0.462877930720154 0.208035803825027 0.606869006043246 0.454564742740527 0.217619753274558 0.589761880771731 0.67074890895275 1.0 0.0734166844690685 0.851938911871758 1.06723153268454 0.0028394589784958 1.14064821715361 0.003720919926498 partial_or_other True False False False True False True 2 residual_state_candidate +SNRPN 0.648293424752274 0.214184649905955 0.612503123972664 0.645653087487303 0.21673193293799 0.588543145051259 0.176356908868357 0.795394757194393 0.852517408528849 0.0574511026544237 1.02887431739721 0.0501419263728687 partial_or_other True False False False True False True 2 residual_state_candidate +SCAP -0.344185648279392 0.215348518664903 0.614002068610328 -0.351290700522411 0.20581314226785 0.578776160707106 -0.836845358342263 0.0184890263133513 -0.0857349350071813 0.788102350183903 -0.922580293349444 0.0131086841178374 persistent False False False False False True False 2 insufficient_or_context_specific +NOTCH3 0.706362404707642 0.215419411166859 0.614038375566873 1.02016618458217 0.0770008651433396 0.455668688469891 1.75662846961702 0.0818345959822526 2.0 2.03828895880972 4.06243374375236e-05 -1.07257847383041 0.001541021056078 0.965710484979315 0.0051993203109709 reversed True False False False True False True 2 residual_state_candidate +PHLDB3 -0.327781166468778 0.215676337197765 0.61460479571768 -0.51921777463975 0.0379749445660528 0.379484931484566 -0.69760868712279 0.0567511170678828 -0.363728083635584 0.255801502588899 -1.06133677075837 0.0104470369805435 persistent False False False False False True False 2 insufficient_or_context_specific +TXLNG 0.286179385455135 0.215880707403565 0.614785400947214 0.269608801013478 0.245275851386637 0.610669341516615 0.0356728762147355 1.0 -0.616655089193386 0.0531259141127786 -0.175789743967062 0.531071146044223 -0.792444833160448 0.0186497252475448 persistent True False False False False True False 2 cross_species_direction_conflict +CRYBG3 0.438106704786599 0.215947688714142 0.614785400947214 0.501181674718307 0.153832220395876 0.536703874670957 0.980119361294493 0.118029091868326 2.0 -0.980727106586135 0.0045462056853216 0.176631599277358 0.50716187040078 -0.804095507308777 0.013722375954537 persistent True False False False False True False 2 cross_species_direction_conflict +FUNDC2 0.370099844703034 0.216007264940419 0.614785400947214 0.0505410172483468 0.866754653312801 0.958391272020028 0.6161750440589661 1.0 0.473912490744418 0.0724417790358626 0.312277455997503 0.150636637915402 0.786189946741922 0.008588523543753 partial_or_other True False False False True False True 2 residual_state_candidate +ST3GAL1 -0.205535585941719 0.216334326454399 0.614985950109195 0.007248145958888 0.968656166252136 0.991283493582442 0.126483066551302 1.11391167202242 2.0 -0.505733215833927 0.0655298962149967 -0.0631489766257048 0.80868619772234 -0.568882192459631 0.0362865701023447 persistent False False False False False True False 2 insufficient_or_context_specific +MBTPS1 0.230623471974198 0.21775090506044 0.617508822072515 0.135466424888219 0.474287774396946 0.776722556550792 0.472863101394228 1.0 0.112294934891313 0.664875881263502 0.267029783509552 0.18389220425926 0.379324718400865 0.0840732234422446 partial_or_other True False False False True False True 2 residual_state_candidate +UAP1 -0.538338791908337 0.218416188950533 0.618140683181076 -0.668360215334249 0.121794071468342 0.503485437181972 0.0416113398180764 0.2597213711014439 0.0286389270817112 3.0 -0.648628000796914 0.0741609870435586 -0.0472937107676829 0.899641920992852 -0.695921711564597 0.0491328445399369 persistent False False False False False True False 2 insufficient_or_context_specific +DOCK4 0.291771504250125 0.221771317102683 0.61959819157717 0.480601361612823 0.03162825138183 0.375031405408838 0.192598360247666 1.0 -0.763733358019812 0.0215467002856288 -0.0257117887396736 0.93713869595612 -0.789445146759486 0.0192797801662944 persistent True False False False False True False 2 cross_species_direction_conflict +TOMM7 0.422277075130927 0.222109086817368 0.619842078687204 0.319003100585309 0.354441187436273 0.698014991474228 1.03918090320577 1.0 0.0685280179338112 0.901995164796902 1.00161107158616 0.0149749484183588 1.07013908951997 0.0181711729985829 partial_or_other True False False False True False True 2 residual_state_candidate +GCFC2 -0.2049547961121 0.222135858427155 0.619842078687204 -0.0843640582808869 0.621018521654005 0.85421549797896 -0.707647161403077 0.0933305604830216 -0.429147476122723 0.257202230570591 -1.1367946375258 0.0159880760021986 persistent False False False False False True False 2 insufficient_or_context_specific +CTSB 0.36401563417489 0.226774684490595 0.624488033085994 0.360555268320702 0.232177451024862 0.602195334480623 1.41444013324758 1.0 0.441903739503141 0.239088116413773 0.155202302995209 0.652241006707125 0.59710604249835 0.0923888670855275 partial_or_other True False False False True False True 2 residual_state_candidate +TRIM14 -0.330937439285953 0.227148121252029 0.624853546501544 -0.191381876712643 0.490628693507508 0.785169491036864 -0.825159746619835 0.0137468255638243 0.160042968778457 0.565809395582846 -0.665116777841378 0.0328385135242499 persistent False False False False False True False 2 insufficient_or_context_specific +NTHL1 -0.536184296228761 0.227355829179527 0.624853546501544 0.0891943067872132 0.849242678041098 0.953127856970211 0.551488547516407 1.0 -0.555139479299602 0.0930816267389048 -0.046660365330667 0.888095273152991 -0.601799844630269 0.0604551190265147 persistent False False False False False True False 2 insufficient_or_context_specific +RECK 0.290396054244902 0.230160796739412 0.626974093492763 0.505866925844323 0.0374148126662806 0.379484931484566 0.698920120171237 1.0 0.0485946321613026 0.899324836501662 0.424030646238076 0.102679345813344 0.472625278399379 0.092825504411424 partial_or_other True False False False True False True 2 residual_state_candidate +HNRNPDL -0.201002081978215 0.234588098053463 0.633274624694561 -0.0452100338684465 0.782201366305677 0.924647355053618 -0.61871603874852 0.086440656850712 -0.396750499867927 0.215710958319311 -1.01546653861645 0.0125670450878044 persistent False False False False False True False 2 insufficient_or_context_specific +MYOF 0.617442301946878 0.236501912889434 0.634711196312224 0.705373896195522 0.172637654470687 0.553858965567902 0.283027585004841 0.330388989860813 0.254221659620373 0.26123011262705 4.0 1.5118634601188 0.0146785291138665 -1.27579676889687 0.0206119067580515 0.23606669122193 0.682937653801204 reversed True False False True False False True 2 insufficient_or_context_specific +PMP22 0.331429863777016 0.237853663102106 0.635230791037838 0.40265208317429 0.148467139617666 0.533583468169136 0.605642697177789 0.3138880178672639 0.0933082587103657 3.0 0.195670579882725 0.491778292195759 0.619820347207841 0.0178897515223553 0.815490927090566 0.0082252751596887 partial_or_other True False False False True False True 2 residual_state_candidate +SSR1 0.281810306294012 0.238212608969117 0.63543424090347 0.603240555784636 0.0109689599324785 0.302570357129259 0.0404622695720676 1.0 0.217198878114479 0.501818609344671 0.288664090558675 0.275287034198583 0.505862968673154 0.0813383097924809 partial_or_other True False False False True False True 2 residual_state_candidate +EPB41L3 0.437863638921962 0.241104564411296 0.640162035467699 0.326126158555762 0.386920703280199 0.720477739899883 0.67068364652272 1.0 -2.0266699041474 0.031842265577242 0.610196577785741 0.479189211417546 -1.41647332636166 0.0833778130497341 persistent True False False False False True False 2 cross_species_direction_conflict +TXNRD1 0.376734408865771 0.242342969763387 0.641246912160877 0.354230465027318 0.27406155077571 0.637623822254105 1.85558943196843 1.1415794281911 0.202995902390653 0.0585636516343868 4.0 0.432055868649603 0.133260287707335 -0.145009235832788 0.567481884798988 0.287046632816815 0.279893024623986 partial_or_other True False False True False False True 2 insufficient_or_context_specific +GBE1 0.360042750293614 0.242887812196045 0.641744124415877 0.521911787030591 0.0798917080141576 0.459671200661295 0.326639345397394 1.0 0.240149348268836 0.634515478880891 0.53649306428649 0.164456081136554 0.776642412555326 0.0733831104658131 partial_or_other True False False False True False True 2 residual_state_candidate +TBL1XR1 0.249662857426714 0.243188523939692 0.642056623094591 0.286997574629371 0.177046718902756 0.559323536258318 0.419105472548852 0.140300758498381 0.152770201805153 0.534688835450744 0.571875674354005 0.041478906151431 partial_or_other True False False False True False True 2 residual_state_candidate +AP2B1 0.228765642371458 0.244069548024196 0.642250060235767 0.119772241083229 0.531189001298063 0.808309703246818 0.350359029950347 0.149433990865996 0.0377478852799225 0.873181154952904 0.388106915230269 0.0918584513043619 partial_or_other True False False False True False True 2 residual_state_candidate +YTHDF3 0.22148722172619 0.244137053933162 0.642250060235767 0.151514597328815 0.428234016850073 0.74799415349718 0.5485178832770871 0.0620215845897053 0.0465108421813012 3.0 0.386982452591684 0.242286508587663 0.488286429159893 0.0930553355954398 0.875268881751577 0.0150023143202489 partial_or_other True False False False True False True 2 residual_state_candidate +BTG2 0.585436181899346 0.244703615412923 0.642250060235767 0.0405632372525499 0.935817623960933 0.981850588669336 0.368704757120109 1.0 -1.00380308514399 0.0082299594666707 -0.152122979958664 0.62806197945583 -1.15592606510266 0.0055043335418112 persistent True False False False False True False 2 cross_species_direction_conflict +CCNY 0.204503827849047 0.244868026836628 0.642250060235767 0.359446692085003 0.0381593884846428 0.379484931484566 0.152619497789844 0.546443183042633 0.400753302156384 0.0569261650751734 0.553372799946227 0.0232417945936453 partial_or_other True False False False True False True 2 residual_state_candidate +CNN3 0.313236483191148 0.245363637462872 0.642250060235767 0.299953910041103 0.267468133660568 0.630904502946442 0.343102874330701 0.157267728543127 2.0 0.391759377458792 0.184286358588836 0.72693108670138 0.0138796090199444 1.11869046416017 0.0035440769053387 partial_or_other True False False False True False True 2 residual_state_candidate +CLDND1 0.323306324966732 0.2455669656482 0.642250060235767 0.658912836019099 0.0126404133123302 0.313114831651016 0.0354984538187267 1.0 0.2093590717394 0.556679770069392 0.380261334369325 0.173810700150191 0.589620406108725 0.0621281935777526 partial_or_other True False False False True False True 2 residual_state_candidate +HERPUD2 0.239429650277063 0.246445540093583 0.644211936694243 0.261956215551626 0.203726975270733 0.577025563405608 0.382619697002 1.0 0.273739957409184 0.436865678258403 0.415098038256306 0.133728849551785 0.688837995665489 0.037480318894471 partial_or_other True False False False True False True 2 residual_state_candidate +FRMD4B -0.382223078814381 0.250133204888674 0.648393414489227 -0.314205683233731 0.345005098348429 0.690926371085492 0.401787789211749 0.6848662847131569 2.0 -1.09940415116538 0.0159342287316698 0.104444924604896 0.797275685701496 -0.994959226560479 0.024035150684762 persistent False False False False False True False 2 insufficient_or_context_specific +MIGA2 -0.292159921648797 0.253857970797356 0.653385791496313 -0.440364992600866 0.0863300531978679 0.467677448123587 0.6800073971602572 0.5010364789804129 2.0 -0.651455779345146 0.0658389405774229 -0.0872743690383289 0.7935978692796 -0.738730148383475 0.035665069179295 persistent False False False False False True False 2 insufficient_or_context_specific +LIPA 0.293341229232911 0.253915694497951 0.653385791496313 0.278974517616773 0.28010192287221 0.642475798758375 0.0950053393627444 0.846511722732485 0.604851348882641 0.0858695767335955 0.699856688245385 0.0646806258191856 partial_or_other True False False False True False True 2 residual_state_candidate +XXYLT1 0.248095844847939 0.25504396772287 0.654871771711577 0.0783079076618479 0.724817371329421 0.902751186327241 0.9992735032001321 1.0 0.31983679052212 0.474809267094997 0.382942841252578 0.253378072684714 0.702779631774698 0.0779924678206557 partial_or_other True False False False True False True 2 residual_state_candidate +COP1 0.164278517156665 0.258784984010028 0.656475699466093 0.262554039334745 0.0592772927212941 0.428473540531152 0.28148455400368 0.519022082221429 0.545951167788281 0.110359424362854 0.827435721791961 0.0390584644465845 partial_or_other True False False False True False True 2 residual_state_candidate +MANBA 0.222084679891425 0.262335581640569 0.65930470625116 0.300120207568192 0.120570497211172 0.501569467909992 0.319283209233279 0.390158997399646 0.274744931728952 0.34071478079604 0.594028140962231 0.080586674882408 partial_or_other True False False False True False True 2 residual_state_candidate +PARVA 0.28147198341766 0.263040493228265 0.660604549834448 0.222184836021427 0.382141351588902 0.718152491804259 0.308347842758379 1.83666126129372 2.0 0.190545614170344 0.455043505586546 0.288636493761551 0.171548362140436 0.479182107931895 0.0447156061526592 partial_or_other True False False False True False True 2 residual_state_candidate +ARID4A 0.171033501302098 0.266198462282971 0.663681248836326 0.0039191899354999 0.979852513082921 0.993974138463632 0.0960971651303388 1.0 -0.55477377751967 0.0242049491371423 -0.118687533884069 0.574239428989965 -0.673461311403739 0.0109999242059563 persistent True False False False False True False 2 cross_species_direction_conflict +BHLHB9 0.38188570768039 0.269339671922133 0.666437369616563 0.57594420549114 0.0920418089770497 0.472460751419842 0.15281517168579 0.801209371511749 0.742402708329573 0.0651813483869062 0.895217880015363 0.0559228447713581 partial_or_other True False False False True False True 2 residual_state_candidate +EVL 0.215900540234005 0.270028117568953 0.667222685933312 0.244874610949436 0.207031973582857 0.5799531910554 0.314121371326469 0.506793328597637 0.376613613860401 0.391344317837425 4.0 0.978747674769773 0.0170520205894316 -1.60479958603379 0.0014550940008916 -0.626051911264017 0.103327386089656 reversed True False False True False False True 2 insufficient_or_context_specific +TOX4 0.230521705986424 0.270377788470323 0.667448704252917 0.0086446171960751 0.965813555724205 0.990675792866759 0.239229835759784 0.50870003179739 0.363596498604628 0.197390308259075 0.602826334364412 0.0633555329961591 partial_or_other True False False False True False True 2 residual_state_candidate +RFX2 -0.54296398843453 0.270576119150963 0.667448704252917 -0.705178864173978 0.156342974641766 0.539558215777 0.4362047781663629 1.0 -1.2205113361297 0.0198043160153482 0.233994274562125 0.607965799365606 -0.986517061567578 0.0405196423106954 persistent False False False False False True False 2 insufficient_or_context_specific +VASN 0.425137380470746 0.272231298846819 0.668772996929307 0.695227568310939 0.0815008513548487 0.461068439742811 0.192077949029642 0.309920034985983 0.0402262974818287 3.0 0.390424092542966 0.128871924761007 0.654496678389861 0.0114136742455974 1.04492077093283 0.002729355358263 partial_or_other True False False False True False True 2 residual_state_candidate +EVA1C 0.321965471563747 0.273797254451143 0.669309995509484 -0.143040150299625 0.603764559059795 0.845325437028836 -1.95193296241088 0.0035842021176591 0.658441539353955 0.214909156703013 -1.29349142305692 0.0206212459289334 persistent False False False False False True False 2 insufficient_or_context_specific +KARS 0.335836681930125 0.273926275235613 0.669309995509484 0.29702517551938 0.335685225994444 0.684461073909613 0.28608515691807 0.381230277697333 0.477460694371927 0.0836014439321775 0.763545851289996 0.0214871634718572 partial_or_other True False False False True False True 2 residual_state_candidate +GOLGA7 0.262112450784909 0.275163535807874 0.670315355235194 0.504714864377934 0.0398571603098512 0.381707279248877 0.0175040150626116 1.0 0.330394937122126 0.155847155576129 0.0648183410904317 0.764920781141384 0.395213278212557 0.0764046920176097 partial_or_other True False False False True False True 2 residual_state_candidate +PTPRG 0.224903191543447 0.277539831034225 0.672049872705933 0.139767226272995 0.501018298837669 0.790819493321426 0.0460509049378879 0.295498442058105 0.0334600907165394 3.0 0.335157781395226 0.389142034854447 0.306241505134899 0.307315771456057 0.641399286530125 0.0727497604795606 partial_or_other True False False False True False True 2 residual_state_candidate +NOS1AP -0.712571552794881 0.279569966157624 0.673526682356923 -0.858112681686122 0.189560317911546 0.569886897607216 -1.68546242156023 0.0203668210600581 -0.536498846891104 0.403459061288665 -2.22196126845133 0.0075508193403489 persistent False False False False False True False 2 insufficient_or_context_specific +FOSL2 0.451992097835933 0.281361215630711 0.673708845130066 -0.282297371178637 0.516055070923273 0.79960514217903 0.416047676925559 0.475181451760402 2.0 -0.720444035379581 0.0860001590682216 -0.352835213381007 0.34342356809709 -1.07327924876059 0.0183249855806438 persistent False False False False False True False 2 insufficient_or_context_specific +PDE4DIP 0.265785371415669 0.281687731712582 0.673708845130066 0.12258696316793 0.620039852250657 0.854061416837891 -0.784336752455881 0.0027982430654098 0.249045908580371 0.195728539996208 -0.535290843875509 0.0201349712657595 persistent True False False False False True False 2 cross_species_direction_conflict +REEP5 0.277929837431934 0.283341990846067 0.67419136040224 0.502901039725376 0.048085586444617 0.402009816708327 0.0506449400471599 1.0 0.344726274094301 0.237230979392939 0.178590855045969 0.480914245497935 0.52331712914027 0.062480275643065 partial_or_other True False False False True False True 2 residual_state_candidate +GRIPAP1 -0.261936092863436 0.284772997749435 0.674513014896952 -0.124996686350525 0.610111184382467 0.848354258489409 -0.517649827387963 0.0692587609365613 -0.372523519798443 0.141859116007898 -0.890173347186406 0.0075508193403489 persistent False False False False False True False 2 insufficient_or_context_specific +HOOK2 -0.291227425522053 0.285509563562355 0.674666511211132 -0.562178522285501 0.0339392957548903 0.376543096535729 0.974058517618476 1.0 -0.505716294460711 0.0575029176865506 -0.555122499524451 0.0298413545276575 -1.06083879398516 0.0029903730695318 persistent False False False False False True False 2 insufficient_or_context_specific +GLT1D1 -0.619582510460633 0.287183023201291 0.676113727797714 -0.616501299410961 0.290241050542601 0.649780536816961 -1.11075922416435 0.0108029393775789 0.22291950397662 0.534688835450744 -0.887839720187728 0.0280172459740103 persistent False False False False False True False 2 insufficient_or_context_specific +KLF2 0.568285936762241 0.290020327974807 0.678191500057146 -0.244393256439448 0.668192340405425 0.87571682348566 0.579902170208908 1.75231555140948 2.0 -0.997285483242555 0.0128876958170517 0.389194592416313 0.231136840280761 -0.608090890826242 0.0817798182254771 persistent False False False False False True False 2 insufficient_or_context_specific +COL6A3 0.345152151769785 0.290655120425019 0.678578043038158 0.0530186646009402 0.873164107142754 0.959263070839262 0.626281553961479 0.464508270586801 2.0 1.73474001032796 0.0002660197556998 -0.878293607850502 0.0101899517752211 0.856446402477462 0.0158669493429928 reversed True False False False True False True 2 residual_state_candidate +SS18 0.17872048567916 0.291466516942701 0.678578043038158 0.152682946632268 0.368589941275295 0.708847468121049 1.20667188160377 1.0 0.21715670571413 0.432313793181377 0.302545673598684 0.182678535460983 0.519702379312814 0.0453796807370346 partial_or_other True False False False True False True 2 residual_state_candidate +CEBPB 0.427870524163306 0.292115225847628 0.678578043038158 -0.0139814811058215 0.97249566835029 0.992040338141303 0.327150410315359 0.413596877413188 2.0 -1.02296969566978 0.0061784547494647 0.26055411879581 0.370512819993476 -0.762415576873971 0.0252806757194213 persistent False False False False False True False 2 insufficient_or_context_specific +UBQLN1 0.176825532407118 0.2925046428773 0.678578043038158 0.198913767223406 0.231374232485806 0.601518427890281 0.0870227697104421 0.805552327346006 0.66856995298178 0.0184612521228585 0.755592722692222 0.0161359674491822 partial_or_other True False False False True False True 2 residual_state_candidate +KDSR 0.221688983730716 0.293528983736306 0.679473582610813 0.309745356343006 0.134874496987782 0.521613530841394 0.0383238641843669 1.0 0.277365981285601 0.357118365608029 0.214938903645269 0.379351287249084 0.49230488493087 0.0784897222483681 partial_or_other True False False False True False True 2 residual_state_candidate +HPX -0.494076956854896 0.297971306844398 0.683099082571166 -0.509125072012019 0.283217660662274 0.644071250922027 -1.38513625096448 0.0194526316654516 0.08240517161052 0.884072832007863 -1.30273107935396 0.0247545211800604 persistent False False False False False True False 2 insufficient_or_context_specific +DIAPH1 -0.305504960834548 0.298917521313287 0.68384785162735 -0.327698627694346 0.263888806479253 0.626379950271573 0.168565360577462 1.0 -0.704426875233774 0.0137468255638243 0.276149769393335 0.231818483287446 -0.42827710584044 0.0859744602878805 persistent False False False False False True False 2 insufficient_or_context_specific +FUT10 0.193745129508667 0.300058210311603 0.685016549665172 0.241536101768992 0.195633526903171 0.571527055075728 0.570348138513078 0.4356137369053479 0.0654575539180646 0.0452025704109527 4.0 0.437696046277784 0.237101728078376 -0.354038069966318 0.245837261092544 0.0836579763114667 0.831102947732424 partial_or_other True False False True False False True 2 insufficient_or_context_specific +UBL3 0.173637575403775 0.301111946736337 0.685730686665997 0.286488316590723 0.0848756536755794 0.465302662671366 0.0681528864968703 0.843955517171545 0.787470627285192 0.0077419401945864 0.855623513782063 0.0077879494257007 partial_or_other True False False False True False True 2 residual_state_candidate +RAB1A 0.221359445603683 0.301806311649288 0.685730686665997 0.290901453318657 0.170475239057955 0.5509452403404 0.115696919130891 1.0 0.0197759173170264 0.953173095923033 0.59876305217169 0.0190874425109485 0.618538969488717 0.0223341774081955 partial_or_other True False False False True False True 2 residual_state_candidate +RAB2A 0.170032962786124 0.309621355468526 0.692554584050891 0.311821892892962 0.0614166395126275 0.430431237459066 0.0958234913996383 0.759902030524495 0.462501820004519 0.0584499360472033 0.558325311404157 0.0364664643591457 partial_or_other True False False False True False True 2 residual_state_candidate +PLEKHA7 -0.329311718093897 0.310959664621833 0.693321067905565 -0.425379283267568 0.183359531264966 0.565541146173142 -0.841537767850605 0.0773897446667143 -0.345414719917074 0.420582922190473 -1.18695248776768 0.0206382943196543 persistent False False False False False True False 2 insufficient_or_context_specific +HADHB 0.223712160690342 0.31100478489014 0.693321067905565 0.225399922080375 0.30719194002864 0.661701213710167 0.480564175227261 0.0570754134405581 2.0 0.241281210648187 0.640640260197348 1.05834161319486 0.0172326114954936 1.29962282384305 0.0114047008041178 partial_or_other True False False False True False True 2 residual_state_candidate +HIP1R -0.633094458193563 0.312138588461819 0.693580991012765 -0.884048707599164 0.142900320462635 0.528641059370883 -1.60102671724501 0.0002635483033429 0.40918468019552 0.137775269393402 -1.19184203704949 0.0029769970020452 persistent False False False False False True False 2 insufficient_or_context_specific +PIGK 0.283936496859094 0.312342059859434 0.693580991012765 0.669213060290946 0.0141158225372719 0.315120450680315 0.108070135918422 0.718757745163049 0.529559898983859 0.0294137484519085 0.63763003490228 0.0206212459289334 partial_or_other True False False False True False True 2 residual_state_candidate +EZR 0.415823527398125 0.312995454535972 0.694099140724804 0.258595854710568 0.526294128258254 0.804819865166353 -2.27444522166029 0.0125987864903197 0.365102754202701 0.632802046256331 -1.90934246745759 0.0256893155221966 persistent True False False False False True False 2 cross_species_direction_conflict +RABAC1 0.368087411621444 0.318050947090336 0.69725537777819 0.430913730627565 0.245297279538924 0.610669341516615 0.0636217597334339 0.898032157168735 0.874961677540613 0.0207984171306111 0.938583437274047 0.0212981603895768 partial_or_other True False False False True False True 2 residual_state_candidate +TAF4B 0.312703199442754 0.320132602913127 0.698784347635265 0.283621635403806 0.367910474903857 0.708317354196916 0.416783662699267 0.576857939959827 0.653349232754719 0.171531654489198 1.07013289545399 0.0816121440051918 partial_or_other True False False False True False True 2 residual_state_candidate +PSMD6 0.266248460839922 0.321763375972531 0.699787065268571 0.224714629403139 0.402076615367857 0.731161712892496 0.160500248093643 0.584876029901657 0.781353370457459 0.0061425723558874 0.941853618551102 0.0044943547162726 partial_or_other True False False False True False True 2 residual_state_candidate +EIF1 0.28738452822584 0.322055820244363 0.699787065268571 0.160486308873236 0.585901556279146 0.83502769041167 0.4998637366907229 0.0398371336865753 2.0 0.414509917250929 0.259653672584307 1.30724337137707 0.0018324723931366 1.72175328862799 0.0017408529894732 partial_or_other True False False False True False True 2 residual_state_candidate +DYNLT3 0.395132975774544 0.32311401599647 0.701076403799986 0.178142332016915 0.650734787143442 0.869901306439436 0.320708792171977 0.289629867960662 0.855056952750584 0.0052774696002589 1.17576574492256 0.0028314304004382 partial_or_other True False False False True False True 2 residual_state_candidate +SLC22A5 0.342268212729505 0.323352626183259 0.701169081972641 0.444156797644957 0.200460683109009 0.575559158741573 0.0187654480107602 1.0 0.0905654841609332 0.853475807498588 0.527004577052159 0.1012582955774 0.617570061213092 0.0878573955024189 partial_or_other True False False False True False True 2 residual_state_candidate +ELL2 0.492993352571425 0.331149185775886 0.706568009779684 -0.0350951312084191 0.946593320221378 0.985614622770938 -1.06656023783868 0.0017632299878147 0.489227071317261 0.0533438006872522 -0.577333166521422 0.032998538588555 persistent False False False False False True False 2 insufficient_or_context_specific +APOOL 0.203013552319316 0.332404929333819 0.707424157207511 0.0769835366895123 0.716684623334852 0.897798167383567 0.310952467653413 0.359385535310123 0.75781425471846 0.0119325691705398 1.06876672237187 0.0056360310187644 partial_or_other True False False False True False True 2 residual_state_candidate +SLC15A4 0.227073520135518 0.334184941805859 0.709266578146451 0.312022037272857 0.182155460097373 0.56456240235188 -0.816638613592073 0.0563905758286447 0.12344872949371 0.755283360182686 -0.693189884098363 0.0824772797392822 persistent True False False False False True False 2 cross_species_direction_conflict +RGL3 -0.288248855408832 0.335148048476565 0.709266578146451 -0.467509607418143 0.0951143570594925 0.475178240428531 0.831480651319594 1.0 -0.519570217845207 0.0721214540222476 0.0006870305946295 0.998228817746804 -0.518883187250577 0.0615767601338601 persistent False False False False False True False 2 insufficient_or_context_specific +ZBTB20 0.206783113338193 0.336083524528848 0.709390214309391 0.163583951005065 0.447958667794774 0.762215570439521 1.36728912896836 1.94833828570483 0.167438782510725 3.0 0.0508778019177218 0.876566872609043 0.683177120915292 0.010890979420327 0.734054922833014 0.0114036369214626 partial_or_other True False False False True False True 2 residual_state_candidate +CD14 0.436265773007415 0.336375912857495 0.709698913531051 0.403883558923144 0.375014460942506 0.712838905321506 0.0205976259214534 1.0 -2.43698348926713 0.043844343625675 -0.607931573170902 0.637595074213904 -3.04491506243803 0.0207654715041743 persistent True False False False False True False 2 cross_species_direction_conflict +TALDO1 0.250834610189202 0.343395663563837 0.714493326322785 0.356140414715962 0.171487236859565 0.552564378607829 0.0238418393031106 1.0 0.418754996213184 0.244079276398375 0.881504369962783 0.0113353783645509 1.30025936617597 0.0038740060991823 partial_or_other True False False False True False True 2 residual_state_candidate +BCL2 0.275327798349746 0.344409638012967 0.714886975735193 0.498179885197081 0.0766964398023495 0.455668688469891 0.617786392510405 0.5214546390831071 0.11815338847774 0.123043944543792 4.0 0.250025015196676 0.517501765079556 -0.775611722847217 0.0275141481921254 -0.525586707650541 0.124091726800373 partial_or_other True False False True False False True 2 insufficient_or_context_specific +HSPG2 0.313849582377125 0.345674914749818 0.714886975735193 0.34919959140073 0.294202022630524 0.652324662738756 0.962971395170698 2.91183962972634 0.257155766074757 0.110062275078593 4.0 0.822855789659478 0.0145779809135334 -0.835313038742721 0.0105365754882872 -0.0124572490832434 0.971821319506505 reversed True False False True False False True 2 insufficient_or_context_specific +RGS9 0.340158327255298 0.346176367646694 0.714886975735193 -0.0709498782076252 0.83868618755934 0.948056613303159 -0.782318768582818 0.0780720615753492 -0.438094951149031 0.270224543662738 -1.22041371973185 0.0142034531575653 persistent False False False False False True False 2 insufficient_or_context_specific +PRG4 -0.405764305767007 0.346280480514947 0.714886975735193 -0.352509384720631 0.415609755664766 0.737532312785253 0.872166172059302 1.0 -2.64756576420334 0.0021799056646577 0.498710155088661 0.454522418557894 -2.14885560911468 0.0069831467285557 persistent False False False False False True False 2 insufficient_or_context_specific +MAGOH 0.315170801420905 0.346282878454666 0.714886975735193 0.0600122612779847 0.847070042352801 0.952541014278606 0.393728038306184 0.229357499164508 0.773340627277238 0.0114633702662042 1.16706866558342 0.0038963175218386 partial_or_other True False False False True False True 2 residual_state_candidate +ADAMTS10 0.246857880727735 0.347180416397082 0.714946525515973 0.405565693196905 0.124566375302757 0.506809938515033 0.5242466071238491 2.08072898322107 0.0915109003480547 0.0616420398711478 4.0 0.0525262463424247 0.906228284504937 -0.290246979713659 0.342417446990403 -0.237720733371235 0.460704588523095 partial_or_other True False False True False False True 2 insufficient_or_context_specific +SELENOT 0.205592454940699 0.351269770129011 0.718364996516247 0.162773400818907 0.461141966989401 0.768909805349668 0.209517791831891 0.48851729371843 0.463275443929269 0.0688639416647823 0.67279323576116 0.023257696200555 partial_or_other True False False False True False True 2 residual_state_candidate +RIN3 -0.222977092311498 0.351897585834704 0.718399424497308 -0.140120909023182 0.560623624019235 0.822697818631225 0.18327652093627 0.6535111176815551 2.0 -0.637813269710622 0.0265736017235449 -0.326497392684574 0.183010982794665 -0.964310662395196 0.0048935938399001 persistent False False False False False True False 2 insufficient_or_context_specific +ME1 0.213512180579836 0.351919096751286 0.718399424497308 0.160827202133467 0.486712807134197 0.782147598778917 0.253634573644745 1.0 0.354973207301508 0.449755919378367 1.38358856263682 0.0038960801203268 1.73856176993832 0.0029769970020452 partial_or_other True False False False True False True 2 residual_state_candidate +TGFB3 0.466442846304133 0.352289333602674 0.718640946452047 0.251984758004304 0.624271099300113 0.855981073559818 1.17824162157783 0.0183104832848435 2.0 1.68219590667587 0.0005851996560389 -0.896997160785634 0.0095358814900854 0.78519874589024 0.034615825666654 reversed True False False False True False True 2 residual_state_candidate +JMJD1C 0.14431309839864 0.355071262596379 0.721486218339601 0.241312273843731 0.109289931305436 0.485176912870447 0.211949424634776 0.7460265738654509 0.0768834977594572 0.0558896965721452 4.0 0.106833761873093 0.684302725098173 -0.0573836432372091 0.790095963285207 0.0494501186358841 0.840032933995614 partial_or_other True False False True False False True 2 insufficient_or_context_specific +LYVE1 0.508512404371158 0.355633395672893 0.721537867317966 0.741560950293879 0.188148328716823 0.56929178900529 0.701902178830016 0.145429855379514 0.615000057884636 0.109177339109458 1.31690223671465 0.0122282451360528 partial_or_other True False False False True False True 2 residual_state_candidate +ATP1B1 -0.273005532121191 0.356135551303444 0.721537867317966 -0.427475440382248 0.159787766862687 0.543504910610905 -0.61454261443903 0.0656279907449452 -0.17180811442217 0.564424993994051 -0.786350728861199 0.0232050006147352 persistent False False False False False True False 2 insufficient_or_context_specific +RBBP7 0.182274513211486 0.360147221378731 0.723308800326545 0.167961800918919 0.399677624993908 0.729679668746226 0.239746453812558 0.352304564489166 0.173443023996523 0.42752013168128 0.413189477809081 0.0849072729056928 partial_or_other True False False False True False True 2 residual_state_candidate +ATP6AP2 0.256498670646086 0.365415896564004 0.728416718695005 0.392624252553631 0.161996939341133 0.543541307772207 0.495790389557247 0.137250689042609 0.251624402481108 0.367948065202621 0.747414792038355 0.0280469397924125 partial_or_other True False False False True False True 2 residual_state_candidate +SGF29 0.199027740661795 0.366101334495708 0.729053353040119 0.242889168012526 0.270503099659814 0.634531964851516 0.312038629536169 1.0 -0.614543280661742 0.0253823719144122 0.160451672250112 0.485019188685128 -0.45409160841163 0.0700337101742113 persistent True False False False False True False 2 cross_species_direction_conflict +BLMH 0.23509704942136 0.368204524568185 0.730221691806275 0.287492981084066 0.272945696886249 0.636920920009132 0.0218702277101579 0.953076893194323 0.569040707993302 0.0283794032566847 0.59091093570346 0.0350212285155975 partial_or_other True False False False True False True 2 residual_state_candidate +PSEN1 0.161475037629347 0.369855102630775 0.731671383469312 0.0030827700526257 0.986533409383738 0.995776265418118 0.105274197377256 0.74609209468542 0.345492960988809 0.147448378718022 0.450767158366065 0.0872179798562124 partial_or_other True False False False True False True 2 residual_state_candidate +S100A10 0.437711042608046 0.370571003196585 0.732497508332904 0.609464624703355 0.213948353616247 0.587023575228778 0.0646266332971001 0.888246105077982 0.979423716789387 0.010000202765721 1.04405035008649 0.0107550361347177 partial_or_other True False False False True False True 2 residual_state_candidate +AKAP11 0.181189040350256 0.377934638726236 0.737426230894193 0.135592274639382 0.510644181371355 0.796519013040946 0.226610883855984 0.403835880188581 0.224997920347476 0.31156468421091 0.45160880420346 0.0717443882205309 partial_or_other True False False False True False True 2 residual_state_candidate +ELF2 0.132100709743373 0.379543888389352 0.738922618800748 0.152309920521151 0.309489040662176 0.662858728430055 0.343893113454781 1.0 0.408285893730994 0.121476060047674 0.0105133947322371 0.967917741993375 0.418799288463231 0.0927460130845708 partial_or_other True False False False True False True 2 residual_state_candidate +CPEB3 0.158781422368986 0.384498152094769 0.741805621585671 -0.0551834308314309 0.759679023914239 0.915406319729464 0.343950632658842 1.0 -0.696591923019926 0.0200982979210279 -0.0571509296630699 0.836206283869046 -0.753742852682995 0.01519228421204 persistent False False False False False True False 2 insufficient_or_context_specific +CPD 0.183594635471246 0.38662521680772 0.743586634783422 0.44073182640048 0.0256313494276173 0.351427309358494 0.5579407376736999 1.0 0.409765315767489 0.112010269986413 0.075629612022087 0.739293727798686 0.485394927789576 0.0525586559606965 partial_or_other True False False False True False True 2 residual_state_candidate +TSPAN14 0.212808301328473 0.388979145687398 0.74509419503979 0.174996188360572 0.476591974047692 0.778118997654425 0.0930982952707813 0.798353298690907 0.54318898906308 0.041214331687922 0.636287284333861 0.0334007696885029 partial_or_other True False False False True False True 2 residual_state_candidate +IFITM3 0.247200837381255 0.389113518324276 0.74509419503979 0.394204858069 0.16803168181141 0.547724142193536 0.741486460856057 1.0 0.0244309811839787 0.961509654240006 1.8252077176771 0.0009443333152877 1.84963869886108 0.0017468801289819 partial_or_other True False False False True False True 2 residual_state_candidate +RORC -0.560857027064394 0.389298684191189 0.74509419503979 -0.925328911769133 0.142796833981057 0.528588319499865 -1.46827308920844 0.0002618664872424 0.552117441364252 0.0374207190895467 -0.916155647844184 0.0055480039049741 persistent False False False False False True False 2 insufficient_or_context_specific +KXD1 0.198928760185547 0.391500102725939 0.745767047882111 0.163979659680193 0.477387076273098 0.778537650801879 -0.670636142782045 0.0644676477365861 0.0404796313537056 0.911984489032477 -0.630156511428339 0.0676701997856136 persistent True False False False False True False 2 cross_species_direction_conflict +NDFIP2 0.181744208824969 0.391597318530091 0.745767047882111 0.173659616759157 0.413233690473327 0.735861242033629 0.256081178358716 0.499773360451384 0.370771645414245 0.19746976542421 0.626852823772962 0.064423393571924 partial_or_other True False False False True False True 2 residual_state_candidate +SMARCA5 0.115116722114684 0.392035290887657 0.745991721961924 0.123454494712905 0.35664210433555 0.700023673094392 0.326566804072574 0.67399163617265 0.938946769649417 0.0647828528384819 1.26551357372199 0.0436655426365506 partial_or_other True False False False True False True 2 residual_state_candidate +PSMD2 -0.209862786551261 0.396864139214398 0.748899299700736 -0.337009570099341 0.176584346283378 0.558531314577562 -0.590650106106736 0.0302653040912309 0.149582382306132 0.523973411535178 -0.441067723800604 0.0784570515851563 persistent False False False False False True False 2 insufficient_or_context_specific +FAM160A1 0.38705587624148 0.397382066394114 0.74947478688622 0.230922243135611 0.610908703692325 0.848390744855719 -1.9258545879818 0.0121357494829551 0.696616128961641 0.284635847796219 -1.22923845902016 0.0539916047406627 persistent True False False False False True False 2 cross_species_direction_conflict +LBH 0.306168710156284 0.398823776461253 0.750584925468433 0.301877807646273 0.405704685337427 0.733444811508554 0.384752270627392 0.396199869228664 2.0 2.24066815425301 0.0001916743621512 -1.20918955283112 0.0054451042448924 1.03147860142189 0.0155687946361287 reversed True False False False True False True 2 residual_state_candidate +SMAP1 0.149804349481983 0.400151515087974 0.752011337895841 0.317921196918211 0.0583522836625031 0.42715254026823 0.370562308951687 0.218250507709268 0.277311808688243 0.26192288460731 0.647874117639929 0.0318891712053751 partial_or_other True False False False True False True 2 residual_state_candidate +ITGA7 0.596113036353146 0.408346158394028 0.756106408334646 0.813686122111296 0.282698324005741 0.64385269936649 -1.31613362990953 0.075785805452977 -1.10934773626541 0.12732969543146 -2.42548136617495 0.0084245433417565 persistent True False False False False True False 2 cross_species_direction_conflict +TRIB1 -0.53367821444621 0.408568337105987 0.756223157073072 -0.691889539282258 0.279593799480895 0.642114507827558 0.481533034665896 0.5692521027690041 2.0 -1.03484192063479 0.0069937307540294 0.310610617050061 0.298181174204016 -0.72423130358473 0.0328447699088656 persistent False False False False False True False 2 insufficient_or_context_specific +SNX21 -0.214934008644558 0.409473789120758 0.756890873361557 -0.288057101823905 0.260673520265793 0.623372826039918 0.5392041333793621 1.0 -0.514509162195011 0.0509801141691565 -0.101992764231033 0.667577402578323 -0.616501926426044 0.0226846510779793 persistent False False False False False True False 2 insufficient_or_context_specific +CELF2 0.289633138569892 0.410807739406771 0.758184407090466 0.0191297186161652 0.956980654217961 0.987656798648419 0.577173531076405 0.33270217640567 2.0 -1.49834440918182 0.0026438134795348 0.273252137758029 0.459377407927345 -1.22509227142379 0.0088333672976549 persistent True False False False False True False 2 cross_species_direction_conflict +TM9SF2 0.18280219136592 0.41126334506656 0.758184407090466 0.216875565353115 0.327558627078963 0.676889991422347 0.0672365405162916 0.844911955127034 0.409095055640351 0.0933547551090149 0.476331596156643 0.0708795453051558 partial_or_other True False False False True False True 2 residual_state_candidate +GPM6A 0.279372058701075 0.411882604997965 0.758505853279408 0.161475065259905 0.63480274747161 0.861847932958146 -2.73673492660132 0.0009638872987954 1.16889339127538 0.0499875452219108 -1.56784153532594 0.0155963110768663 persistent True False False False False True False 2 cross_species_direction_conflict +PLEKHA3 0.243513767989755 0.414241787411676 0.76037856770047 0.324347649566844 0.275839492305844 0.6396696093258 0.305615336505083 1.0 0.14128757103277 0.674997859030404 0.413611095302183 0.107975629911441 0.554898666334953 0.0544638227499325 partial_or_other True False False False True False True 2 residual_state_candidate +PAPSS2 0.238368113319207 0.414894183917232 0.76076641167561 0.0272511618392017 0.926090989542947 0.978760367967803 0.986236344238859 1.0 0.012571765330065 0.981491186794154 0.775639743013629 0.0489796245256278 0.788211508343694 0.0548933696540216 partial_or_other True False False False True False True 2 residual_state_candidate +PSMG2 0.180197304796818 0.416999287753483 0.761972737989144 0.343875400960976 0.143674369542183 0.530389508260969 0.393108917290478 0.42623387606321 0.510132385726768 0.163179991882361 0.903241303017246 0.0461611909183963 partial_or_other True False False False True False True 2 residual_state_candidate +COPB2 0.187370623486595 0.419913741783321 0.763072166221739 0.335783013535289 0.145544845075189 0.532658823056677 0.0599579786509335 0.0473476767910393 2.0 0.0565223957462511 0.862771772497716 0.351175071023417 0.124322468920001 0.407697466769668 0.0973562140790547 partial_or_other True False False False True False True 2 residual_state_candidate +IARS2 0.146164300813823 0.422062786719247 0.764522343498789 0.0746785837848071 0.673970920515698 0.877796958653688 0.254743163775306 0.325810602767372 0.193022425215264 0.376298316727942 0.44776558899057 0.0676753223629825 partial_or_other True False False False True False True 2 residual_state_candidate +ARHGAP44 0.251172737751779 0.423093590948513 0.764580101763606 0.251455438614454 0.422878476634265 0.744144334629103 0.732261098768765 1.0 -1.45161204521351 0.0137468255638243 -0.120728950294346 0.827521785431756 -1.57234099550786 0.0108387751714437 persistent True False False False False True False 2 cross_species_direction_conflict +ROR1 0.30396382548588 0.425596702106289 0.766016021281657 0.657392870315116 0.0786828649535772 0.457452471464685 0.318133408536677 0.260488949134753 2.0 0.148853503814223 0.875823233133227 1.05201958910168 0.0624461886446697 1.2008730929159 0.0712425366635218 partial_or_other True False False False True False True 2 residual_state_candidate +TMED2 0.246525984752164 0.425730993469328 0.766017543959899 0.240439139898866 0.437195895926349 0.754357618759665 0.30692224955184 0.343534692169519 0.482578074390328 0.0855514290302648 0.789500323942168 0.0194604206862626 partial_or_other True False False False True False True 2 residual_state_candidate +DALRD3 -0.276493255192194 0.426027714333099 0.766269268812412 0.0387622820907021 0.915395124294114 0.974759629076879 -0.555811440770436 0.0509345654920208 -0.128099702874596 0.612521743034383 -0.683911143645032 0.0206212459289334 persistent False False False False False True False 2 insufficient_or_context_specific +FOS -0.573937416140278 0.431822773642147 0.770687147728228 -1.72945928754095 0.0181668284545808 0.32629129734252 0.153485253877965 1.0 -1.6981872014094 0.0130999239733517 -0.338375214970694 0.588396614941279 -2.0365624163801 0.0074966190560345 persistent False False False False False True False 2 insufficient_or_context_specific +PTGES3 0.19683340407853 0.433440056589227 0.771323127839045 0.253787192323197 0.310296874698963 0.663746883608458 0.347250574975833 0.110619620060006 2.0 0.113227274979189 0.656133703731 0.60899256830167 0.0092768518657045 0.722219843280859 0.0068352192594192 partial_or_other True False False False True False True 2 residual_state_candidate +TCEA1 0.126352258398815 0.435327998487908 0.771655590441062 0.245478112350013 0.146463988917772 0.532796338690088 0.0695378475280806 1.0 0.105479063450399 0.859333782100118 0.652338306689316 0.102607045389201 0.757817370139716 0.0867622753581332 partial_or_other True False False False True False True 2 residual_state_candidate +SNRPB2 0.253493142249548 0.435377709455474 0.771655590441062 0.256647477260654 0.430560676310099 0.749361154407231 0.112966232809817 0.831879744189702 0.915584226333844 0.0171024123096465 1.02855045914366 0.0192797801662944 partial_or_other True False False False True False True 2 residual_state_candidate +ARF4 0.166949349217926 0.4368879806488 0.773288063652981 0.0879054026375484 0.687915670066395 0.884546784138472 0.272529732683262 0.413363180793094 0.553865103419552 0.0573227765247507 0.826394836102814 0.0168825953739933 partial_or_other True False False False True False True 2 residual_state_candidate +YIF1B 0.265352068317795 0.437488847644256 0.773887290967011 0.380842664329169 0.269871529120665 0.634515102250495 0.0394143411269486 1.0 0.156129188929316 0.689827572258987 0.537345111852622 0.0728798168940377 0.693474300781939 0.0406828163957319 partial_or_other True False False False True False True 2 residual_state_candidate +TPT1 0.168782468710955 0.440910905037526 0.775222968743735 0.139063433386387 0.526121814387279 0.804819865166353 0.239176089005996 0.651786750749662 1.12844459735985 0.0172879552599406 1.36762068636585 0.0108951287071035 partial_or_other True False False False True False True 2 residual_state_candidate +ZBTB44 0.115058660886082 0.443289536242179 0.775994730998025 0.0377094722660346 0.79855228618328 0.92925379048471 0.249601949217119 0.421192047821615 0.961826336940925 0.0035603090539389 1.21142828615804 0.0025612869102069 partial_or_other True False False False True False True 2 residual_state_candidate +HMGB1 0.129823558561914 0.447730102217644 0.778609336495366 0.122314590346367 0.472790408869941 0.775593712997022 0.256202831614315 0.114194197121386 0.0802029963153651 3.0 0.0178578997647269 0.957440974715565 0.435169189458997 0.06007555084693 0.453027089223724 0.0668394916287327 partial_or_other True False False False True False True 2 residual_state_candidate +NDUFA4 0.207362214025199 0.451082742541455 0.780359101385005 0.0519078046182983 0.853184821971139 0.955140001099702 0.0571663753733128 0.932042397692626 1.74920851040022 0.0031379658270189 1.80637488577353 0.0041720247456539 partial_or_other True False False False True False True 2 residual_state_candidate +FOXN3 0.161681741639368 0.453907795019233 0.781963520146073 -0.0642047678082828 0.775449245910395 0.922188909475326 1.79938910394034 1.0 -0.552833077050945 0.0309403920483937 0.124409884137487 0.576066298803194 -0.428423192913458 0.0705424685398663 persistent False False False False False True False 2 insufficient_or_context_specific +ORM2 -0.390744747795809 0.45858271669943 0.785187011788209 -0.11638436902997 0.832365223902084 0.944822630093409 -2.50619134642958 0.0416638085092641 -0.856077922280987 0.438937154955535 -3.36226926871056 0.0149313846869081 persistent False False False False False True False 2 insufficient_or_context_specific +COBL -0.391370785808323 0.458781840852573 0.785187011788209 -0.535557302106338 0.304747011197203 0.661341495477036 -1.77569461160926 0.0007887292489288 0.576362147382645 0.110465677424102 -1.19933246422662 0.0076810983020722 persistent False False False False False True False 2 insufficient_or_context_specific +SDCBP 0.203067606468727 0.459707601100037 0.785651513174289 0.073640825042437 0.792727093736713 0.927620871373898 0.324915377221256 0.180044343118824 0.247781464284315 0.234018889314441 0.572696841505572 0.023257696200555 partial_or_other True False False False True False True 2 residual_state_candidate +ACP1 0.22179577612565 0.464496605675748 0.788053563778485 0.605080256311535 0.0352528743939995 0.37720666979567 0.0143211356895407 1.0 0.329244821606642 0.304034153533953 0.416989556458713 0.119654961400247 0.746234378065356 0.0229244181563757 partial_or_other True False False False True False True 2 residual_state_candidate +SRSF5 0.114086683491959 0.467661742544537 0.789891845674348 0.0869006498034927 0.584679830590989 0.83427397074951 0.193336581442899 0.520860017236944 0.319577476100554 0.19857302025827 0.512914057543453 0.0604551190265147 partial_or_other True False False False True False True 2 residual_state_candidate +EFNA1 -0.347613402503161 0.46941188052193 0.790690911702383 -0.126902106618362 0.79471349364371 0.928199704380062 -1.37253751340086 0.0012816834328547 0.479008785667081 0.111623034729861 -0.893528727733776 0.0134226145927561 persistent False False False False False True False 2 insufficient_or_context_specific +GCA 0.239177018875807 0.469964411859339 0.790864561748629 0.250136531581017 0.451540641212396 0.764202910889105 -0.815190575473565 0.0957698029306521 -0.30803075545617 0.48948076456853 -1.12322133092974 0.0287788157643438 persistent True False False False False True False 2 cross_species_direction_conflict +MYRF -0.338520331065045 0.472751432238143 0.792635953231448 -0.322437257663581 0.495817552372434 0.78802374197624 -2.01995935350243 0.0017898721875376 0.414739411229149 0.368723070036641 -1.60521994227328 0.0071394451417332 persistent False False False False False True False 2 insufficient_or_context_specific +BLCAP 0.138282633633511 0.475558335219077 0.793680078545987 0.0478168365053192 0.802610045749316 0.93089716170727 0.8539683381200509 0.39372835482112 2.0 0.349634925158594 0.23692077232544 0.137364908303273 0.588875363270651 0.486999833461867 0.0822827485117321 partial_or_other True False False False True False True 2 residual_state_candidate +DDB1 0.129369760402354 0.476698056550085 0.794095626547144 0.112030226900109 0.537407636853659 0.812087893451657 0.524021948460492 0.141983365845718 0.100944359441803 0.748207782550289 0.624966307902295 0.0681309513002546 partial_or_other True False False False True False True 2 residual_state_candidate +ALAS1 -0.376403127038602 0.476807066622965 0.794151918189819 -0.707700825918464 0.178671574549876 0.561600025036498 0.334837518898258 1.0 -1.65666015349619 0.0297396835435871 0.476707717498402 0.458052025449377 -1.17995243599778 0.0863376956858805 persistent False False False False False True False 2 insufficient_or_context_specific +BET1L 0.196334255163692 0.478022328969371 0.795319193975074 0.0440865593528578 0.867842284140463 0.958502690861149 -0.536617994848386 0.0511659313602428 -0.172374627354789 0.470526158925892 -0.708992622203174 0.01588969915473 persistent True False False False False True False 2 cross_species_direction_conflict +HP 0.228076405482119 0.481018015145215 0.796891291997989 0.344435099132959 0.293113342356563 0.651509781962399 -1.63168861730456 0.0119653473629702 0.366306576795971 0.483601536393655 -1.26538204050859 0.033540914967055 persistent True False False False False True False 2 cross_species_direction_conflict +SEMA4G -0.403260185192194 0.481683439126918 0.797249465986022 -0.229179615136822 0.695291842461721 0.887929652374397 -1.20642718186869 0.0042588028208228 0.450653309134595 0.160481025923017 -0.75577387273409 0.0355803255240976 persistent False False False False False True False 2 insufficient_or_context_specific +HADHA 0.128049000541901 0.489648378683169 0.80315053364708 0.151917565227903 0.410209204008612 0.735152897523944 0.185633407834032 0.664875881263502 0.630545245162096 0.0685688160034986 0.816178652996127 0.033540914967055 partial_or_other True False False False True False True 2 residual_state_candidate +ACADM 0.142020654901913 0.492356978082917 0.805065041753048 0.0162049091506181 0.939127415061634 0.983643567603279 0.0465945997073426 1.0 0.350389494755135 0.481841778303459 0.902274292004445 0.0387543140284531 1.25266378675958 0.0149313846869081 partial_or_other True False False False True False True 2 residual_state_candidate +ARHGDIB 0.251494691454462 0.493695520229918 0.806163702707703 0.350351151999602 0.335747670181652 0.684461073909613 0.20662443402764 0.526178746796031 0.762407279694778 0.0114862794644038 0.969031713722418 0.0066676253804751 partial_or_other True False False False True False True 2 residual_state_candidate +KCNAB1 0.261476631807952 0.495254346904802 0.80666217706352 -0.110844703627123 0.758898966051789 0.915406319729464 1.39892976024465 1.0 -1.81410639493529 0.0321880799190357 0.241020816068989 0.770505482908639 -1.5730855788663 0.0456267822505803 persistent False False False False False True False 2 insufficient_or_context_specific +ASB13 -0.266059359007458 0.496125015578739 0.807101373571699 -0.543321978744998 0.143194530655208 0.529397424559285 0.9278226314094301 0.0466829022856249 2.0 -0.564510213179661 0.0367162050426771 0.0126025554808952 0.962701740657235 -0.551907657698766 0.0355264612821072 persistent False False False False False True False 2 insufficient_or_context_specific +ARPC2 0.122293869787373 0.498007184234042 0.808519738417984 0.0037624427592803 0.983338393781082 0.99451887511202 0.289913782161098 1.0 0.25675460289226 0.450470894598921 0.718635918143409 0.0172326114954936 0.975390521035669 0.0080768709650729 partial_or_other True False False False True False True 2 residual_state_candidate +BICDL1 0.489841599731029 0.499241522980963 0.809019813362094 0.449422280530387 0.534675783826873 0.810930391494977 -1.44561077945991 0.0509801141691565 0.191881750553012 0.786241638006412 -1.2537290289069 0.0678132728164929 persistent True False False False False True False 2 cross_species_direction_conflict +TENM3 -0.357586694642462 0.499386296774773 0.809041049769533 -0.396642738939163 0.45328351341406 0.765092566410986 -1.63238110107128 0.003091207359983 -0.0787465807483687 0.876869319001302 -1.71112768181965 0.0038741220603223 persistent False False False False False True False 2 insufficient_or_context_specific +PCDH15 0.331198718690051 0.499831008386215 0.809187062594484 0.302986873514587 0.536350197494098 0.811868872421891 -3.26005840301302 0.00159526589406 0.0933479129826741 0.933477615189771 -3.16671049003035 0.0033507820838639 persistent True False False False False True False 2 cross_species_direction_conflict +SHTN1 -0.192070745339235 0.500670155771296 0.809582804330161 -0.0809896013034875 0.77636725946848 0.922657083010829 -1.22856463038756 0.0003313871346681 0.554351560806341 0.021009926690613 -0.674213069581215 0.0116771587631655 persistent False False False False False True False 2 insufficient_or_context_specific +PTGER3 -0.260643209994767 0.512601403328363 0.815507202676114 -0.016635323487111 0.966837462034162 0.990805143378026 -2.17146098797765 0.0143710819307338 0.580796491918596 0.457575487282213 -1.59066449605905 0.0400325339094177 persistent False False False False False True False 2 insufficient_or_context_specific +EIF4H 0.166029435714018 0.51293617055665 0.815507202676114 0.248925257694664 0.328340680518037 0.677287114006341 0.248628757035444 0.264339763240465 0.0290878477258541 3.0 0.0108061397955576 0.97100168852273 0.385459440809888 0.0674748285531909 0.396265580605446 0.0761110811469107 partial_or_other True False False False True False True 2 residual_state_candidate +PAXX -0.198231772262557 0.513276978904984 0.815653704873327 -0.241866712235145 0.422869331573987 0.744144334629103 0.27629166703613 1.0 -0.792156995928312 0.0152547183418752 -0.465738590971557 0.0960309145782632 -1.25789558689987 0.0028179621895243 persistent False False False False False True False 2 insufficient_or_context_specific +LRRC1 0.260457869523188 0.513401005592546 0.815653704873327 0.491451926923896 0.229263848864091 0.600637150448404 -1.69552551333185 0.0259946798413385 -0.53374620929321 0.453608423534429 -2.22927172262506 0.0098336697502663 persistent True False False False False True False 2 cross_species_direction_conflict +IMPAD1 0.130140523241501 0.516303442321701 0.817003138786741 0.178770131713336 0.37253461885694 0.711175244911062 0.0240298401340157 1.0 0.301181466262485 0.352626919681116 0.204458342078273 0.455197813416598 0.505639808340759 0.0920156064810186 partial_or_other True False False False True False True 2 residual_state_candidate +AHSA1 0.230248110628623 0.5202496855643 0.818344810459857 0.387379012943887 0.292123131322492 0.651509781962399 0.0437818461413596 1.0 0.0478751795700414 0.885130826731918 0.709558004329005 0.0091920347644963 0.757433183899046 0.0101193317680422 partial_or_other True False False False True False True 2 residual_state_candidate +SNU13 0.143982494021003 0.521341922246918 0.818852724647867 0.156604640154756 0.486446720046827 0.782147598778917 0.604957553106732 1.0 0.115015444768601 0.688936764998849 0.624408681276661 0.0139951898468372 0.739424126045261 0.0101460704405942 partial_or_other True False False False True False True 2 residual_state_candidate +GLG1 0.087910659932352 0.52418928670022 0.819874802684524 0.0937257792742866 0.495720264938093 0.788021600136089 0.341649870472169 0.134475264984611 0.31821326042016 0.110940430013661 0.659863130892328 0.010395894143059 partial_or_other True False False False True False True 2 residual_state_candidate +CDC42BPA 0.120171107785992 0.524570118006515 0.819874802684524 0.299759231268636 0.103736879999141 0.479932265033934 1.07409970119691 1.0 -0.590922796090716 0.0364754244804122 -0.0738575628319029 0.776500104941346 -0.664780358922619 0.0215252001116873 persistent True False False False False True False 2 cross_species_direction_conflict +TSPAN9 -0.159097155401771 0.526582724897714 0.820977615101899 -0.135396547146151 0.59110824391275 0.837707495198767 0.3575442653363811 0.423939798001645 0.197175731770537 0.0700451812329979 4.0 0.463335970049375 0.0993609883014627 0.21251657748833 0.378038302944677 0.675852547537705 0.0218442946435074 partial_or_other False False False True True False False 2 insufficient_or_context_specific +SHROOM3 -0.356156825514771 0.526998136792312 0.821042781619483 -0.469440800952966 0.401095155159335 0.73076145783818 -0.921250490654952 0.0540770702690188 -0.349189304431103 0.407892717682048 -1.27043979508606 0.0149313846869081 persistent False False False False False True False 2 insufficient_or_context_specific +MBP -0.198205523135362 0.527591766295712 0.821069135247294 0.0703999451867109 0.824653403537221 0.940911901302771 0.4398780694643579 0.430550252977841 2.0 -1.51665798724907 0.0577091094285948 0.296820205289515 0.693916172262372 -1.21983778195956 0.0932422102479162 persistent False False False False False True False 2 insufficient_or_context_specific +MYO5B -0.3122335689979 0.532952815271327 0.824240578175287 -0.130840749810529 0.798370526231571 0.92925379048471 -2.49675307625635 0.0012811158357901 0.326310485284904 0.559075740544916 -2.17044259097145 0.0040153734093319 persistent False False False False False True False 2 insufficient_or_context_specific +IDNK 0.201984557501675 0.535277978756429 0.825458245904738 0.0279391784526274 0.932283306177598 0.981045440677165 -0.681629785258908 0.0310071580014565 0.0373931879164111 0.904932550966194 -0.644236597342497 0.0350212285155975 persistent True False False False False True False 2 cross_species_direction_conflict +MPP7 -0.249808270701395 0.535341338574733 0.825458245904738 -0.578696214795524 0.135190244998876 0.521860900181769 -0.810780019880754 0.0453495678895803 -0.0194241567267736 0.962042942424955 -0.830204176607527 0.0358137161030606 persistent False False False False False True False 2 insufficient_or_context_specific +PLEKHM3 0.154959992887492 0.536791575928835 0.825746208074922 0.144442462015457 0.564830029622724 0.823754286312897 0.322188861078353 0.054412740092305 2.0 0.694538387103289 0.290141236598979 0.476651798973428 0.306126110119931 1.17119018607672 0.054965337972094 partial_or_other True False False False True False True 2 residual_state_candidate +IRAK2 -0.295612974316066 0.551768348252547 0.834605765305838 -0.398098330599688 0.421895620657359 0.743883427338076 1.09851194764943 1.0 -0.570553522218922 0.0757420617530261 -0.0817090193740686 0.787233804574194 -0.652262541592991 0.0400325339094177 persistent False False False False False True False 2 insufficient_or_context_specific +HIP1 0.125340840475006 0.552286118694576 0.834755148669839 0.110817999431731 0.597684197094218 0.842278397346603 0.8402793580387721 1.71419443894486 0.113281169002843 0.0955584117891379 4.0 0.442047841332754 0.159402358847057 -0.434688274942948 0.116136930147546 0.0073595663898058 0.984689765572988 partial_or_other True False False True False False True 2 insufficient_or_context_specific +BTBD1 0.125459009645388 0.556167367767861 0.837304301852713 0.109818588304667 0.606770414286889 0.846931578987574 0.224711378546949 1.0 0.363414457220583 0.320505518455542 0.6996279427638 0.0233502797567654 1.06304239998438 0.0081476871060245 partial_or_other True False False False True False True 2 residual_state_candidate +SEC23A 0.118072276132991 0.556493122606788 0.837418267735444 0.244581363185152 0.213639453359131 0.586328398379439 0.104776014176949 0.709033686275897 0.397721362001814 0.0729205621590317 0.502497376178763 0.0401561794314905 partial_or_other True False False False True False True 2 residual_state_candidate +TNKS2 0.0791166602653517 0.559527705267569 0.839653314432678 0.119575726451157 0.369722395513675 0.709345639075664 0.257166311931696 0.282664389188681 0.115169850611487 0.581169045226566 0.372336162543183 0.0955152398689109 partial_or_other True False False False True False True 2 residual_state_candidate +WHAMM 0.0956487299883272 0.560994825975225 0.840140057594203 0.0767068886534135 0.641288076829031 0.864715136035876 0.529892125223849 1.27495560502122 2.0 -0.67644611710918 0.0232651030967752 0.0369943154891893 0.899903010515023 -0.639451801619991 0.0279405435141411 persistent True False False False False True False 2 cross_species_direction_conflict +UBXN8 0.147461741778389 0.563648870952283 0.841250322238367 0.582322520554528 0.0251030064813536 0.351006805738558 0.161748046309964 1.0 0.083889575754293 0.811836815903341 0.555232838233511 0.0339503617718795 0.639122413987804 0.0283868440287437 partial_or_other True False False False True False True 2 residual_state_candidate +FBXL17 0.120479699908987 0.566429091878803 0.842808157051877 0.15453522526141 0.45983940673173 0.768558565184993 -0.643224781461901 0.020523877905521 0.229871923939889 0.317588196821995 -0.413352857522012 0.0946745219700594 persistent True False False False False True False 2 cross_species_direction_conflict +SORBS3 -0.129885561569686 0.566572545182486 0.842808157051877 0.319746077018911 0.158089145265961 0.541917271337019 0.38242173098817 1.0 -1.20110926124376 0.0236141444282749 -0.0096402713123302 0.986036910838357 -1.21074953255609 0.0225470605348611 persistent False False False False False True False 2 insufficient_or_context_specific +TFB1M 0.121502709443638 0.566664426333645 0.842808157051877 0.163986920488735 0.439635670614639 0.756465679652763 -1.10909211619218 0.0251846901267204 0.282809537037691 0.503230464004836 -0.826282579154493 0.0642543307437862 persistent True False False False False True False 2 cross_species_direction_conflict +HSBP1 0.194560225195722 0.569303252011018 0.844190298019252 0.36565528610031 0.287422369815732 0.647596455327388 0.0777474416811284 0.830039908197609 0.492384582138246 0.0646185894376236 0.570132023819374 0.047104113482389 partial_or_other True False False False True False True 2 residual_state_candidate +WWC1 0.297843567011883 0.570255271314677 0.844544137261939 0.249098748302373 0.635115716938453 0.861847932958146 0.422771180236555 1.0 -0.980789562474979 0.0141442122680699 0.131328364454686 0.703049977644701 -0.849461198020294 0.0260063020234298 persistent True False False False False True False 2 cross_species_direction_conflict +ACBD6 0.110689516841788 0.570368979587406 0.844594065425502 0.21482491104319 0.274413396757406 0.637881251203146 -0.542540708911953 0.0170953331847988 0.0733296329929823 0.710240416469499 -0.46921107591897 0.0301515177113284 persistent True False False False False True False 2 cross_species_direction_conflict +PTPRT 0.260885921958751 0.570791941224581 0.844709570188752 0.249673751334283 0.58751395064035 0.835274227991216 0.0731666437462242 1.0 -6.77562272667048 0.0006376029261132 2.46160826886279 0.232284281291996 -4.3140144578077 0.0031776412702567 persistent True False False False False True False 2 cross_species_direction_conflict +NCKAP5 -0.194370383042772 0.574512731203146 0.845630198807028 -0.409582118838641 0.21861520189299 0.590921480180796 -1.19739666359066 0.0362355323313933 -0.334054929745878 0.515303978941256 -1.53145159333654 0.0139330549530496 persistent False False False False False True False 2 insufficient_or_context_specific +LRBA 0.0888588979431335 0.574750219969628 0.845759537274729 0.120703349227305 0.442136952958013 0.758062305003835 -1.62512013745158 0.0236141444282749 0.202063278651553 0.758627616729666 -1.42305685880003 0.0355722518317312 persistent True False False False False True False 2 cross_species_direction_conflict +VEGFA 0.237901763275437 0.579018338052582 0.849417799592049 0.125352446943848 0.769578636559486 0.920286696658178 0.272708667887771 1.0 -1.24334799675225 0.0009861086199132 0.0395018803692282 0.8958005122286 -1.20384611638302 0.0025612869102069 persistent True False False False False True False 2 cross_species_direction_conflict +PCBP2 0.0668088518688675 0.579162383700097 0.849417799592049 0.150163217414691 0.202307170816009 0.57668584531318 0.26360928560347 0.317990669807999 0.324607659519737 0.145562418823447 0.588216945123207 0.027055110412112 partial_or_other True False False False True False True 2 residual_state_candidate +NRBP2 -0.209535934470791 0.583001632994795 0.851870747436964 -0.244818921395189 0.520490351577057 0.801118945922776 -1.23421237005827 0.0050813992631754 0.188414121456096 0.587929901907543 -1.04579824860217 0.0133006608799467 persistent False False False False False True False 2 insufficient_or_context_specific +TMA7 0.136079082593896 0.583012916629411 0.851870747436964 0.0095094448605938 0.965904206456755 0.990675792866759 0.55921591582964 1.0 0.723438594327217 0.130172890183871 0.944597252388732 0.0206546699505345 1.66803584671595 0.004051719474331 partial_or_other True False False False True False True 2 residual_state_candidate +SPCS1 0.225243346907542 0.585623325516136 0.852880447477481 0.292755215459254 0.484909769523383 0.781510814627977 0.0989824147239113 0.719214521019672 0.67653404240961 0.0077838195144687 0.775516457133521 0.0066221187267941 partial_or_other True False False False True False True 2 residual_state_candidate +TBCD -0.106655424997084 0.585658575886696 0.852880447477481 -0.211455291933428 0.270834770319247 0.634874224029886 0.548183160243108 0.437341867531547 2.0 -0.512793176084916 0.0812181535771459 -0.243146931854469 0.347391388261779 -0.755940107939385 0.0174960524870504 persistent False False False False False True False 2 insufficient_or_context_specific +SPON2 -0.108009627864119 0.586469408173252 0.853300805943653 -0.172289915180351 0.377237646536362 0.714534233402035 0.156136928617487 1.0 -1.29726970973315 0.0066321315509992 -0.837238509530537 0.0418966275830846 -2.13450821926369 0.0017468801289819 persistent False False False False False True False 2 insufficient_or_context_specific +DOCK9 0.108306336542306 0.589124957700636 0.854510413985893 0.209884794829612 0.304579554914159 0.661341495477036 -1.0646104165872 0.0023960341872129 0.388732932881632 0.12843360882828 -0.675877483705567 0.0225896267849194 persistent True False False False False True False 2 cross_species_direction_conflict +DR1 0.13941317725003 0.589980580421585 0.854873832527718 0.189748863500879 0.464852340810343 0.770230855975455 0.2484853151751 0.47982538411702 0.340277556361216 0.20788978364116 0.588762871536316 0.0633319567477082 partial_or_other True False False False True False True 2 residual_state_candidate +PCNX4 0.104361295310961 0.601854837760877 0.86149449255414 0.122486161311527 0.538221271706806 0.812087893451657 0.845671905789018 0.175144956637759 0.157431448775228 0.736127800226638 1.00310335456425 0.0866045669281482 partial_or_other True False False False True False True 2 residual_state_candidate +SLC25A28 0.084511273330469 0.611298833793665 0.864960526893789 0.193680313497651 0.258431367929413 0.622239083830955 -0.530458513744371 0.0384658058904439 -0.276753987774025 0.20936684765636 -0.807212501518396 0.0067160706724334 persistent True False False False False True False 2 cross_species_direction_conflict +COL1A1 0.219218499656961 0.615903849213194 0.867088202872832 0.471419488841859 0.282714634804229 0.64385269936649 0.193955014651018 0.087801450249764 2.0 3.68275268645275 0.0002667833430675 -2.67414294534979 0.0019115534652006 1.00860974110296 0.0995956133651801 reversed True False False False True False True 2 residual_state_candidate +RAB5A 0.0801817159908112 0.617296440541029 0.867435291585338 0.14522636829926 0.354412255558791 0.698014991474228 0.116534949814984 0.692046018169297 0.293642628764847 0.193728450586492 0.41017757857983 0.0955152398689109 partial_or_other True False False False True False True 2 residual_state_candidate +STXBP6 -0.267042799756016 0.619604057658891 0.867724358075884 -0.39485023805308 0.463394342172714 0.769320698854699 -1.55982879122721 0.0205519261009251 0.222085721824037 0.718563392414516 -1.33774306940318 0.0335760319360775 persistent False False False False False True False 2 insufficient_or_context_specific +EMID1 -0.219371328810408 0.628007934064462 0.871073909324171 -0.118745196273621 0.795364850718467 0.928511951999732 -1.35196617090841 0.0353779406380819 -0.411548930485319 0.497773954550746 -1.76351510139372 0.0137092967747645 persistent False False False False False True False 2 insufficient_or_context_specific +RAP1A 0.0915560341549866 0.629589682918235 0.871764966852554 0.0774942978462369 0.68273781109541 0.882074824865184 0.0468668418105185 0.876566872609043 0.711483860062946 0.0054451042448924 0.758350701873465 0.0067677687323908 partial_or_other True False False False True False True 2 residual_state_candidate +PSMA4 0.128387508724541 0.634570438223832 0.873620379028193 0.231361434485175 0.38964327485727 0.722218665388488 0.0191194100976396 1.0 0.163940953872464 0.592444258755827 0.636677650428768 0.0189588865261606 0.800618604301233 0.0107478914135918 partial_or_other True False False False True False True 2 residual_state_candidate +SERPINB9 0.119137616752619 0.636036058449932 0.874156301108355 0.191106511515243 0.440825751394116 0.757156057136665 0.16427322878049 0.802388876152692 0.80243578460662 0.0550646018591449 0.96670901338711 0.0515574264469394 partial_or_other True False False False True False True 2 residual_state_candidate +PTPN13 0.111763803580535 0.641585839045249 0.876825450322796 0.0733804363657805 0.758339563404118 0.91513877133623 -0.645585107894716 0.0648798346150123 -0.0196082663022992 0.955817955085536 -0.665193374197015 0.0494998483193496 persistent True False False False False True False 2 cross_species_direction_conflict +SYNE2 0.126979389983614 0.642101647262476 0.876825450322796 0.156567863730196 0.56453862424229 0.823754286312897 0.5543102113946179 0.691960566513617 2.0 -0.802583751012566 0.0061539711097974 -0.125818983681896 0.592920559221651 -0.928402734694462 0.0042012710851304 persistent True False False False False True False 2 cross_species_direction_conflict +NAA20 0.0947446271332634 0.642616612973695 0.876825450322796 0.0775123171096291 0.704166146916161 0.892245309578453 0.8927712334817021 1.0 0.471494319630229 0.192020764815904 0.604812967342982 0.0496801067517636 1.07630728697321 0.008457030093391 partial_or_other True False False False True False True 2 residual_state_candidate +EDNRA 0.229044407905694 0.642996321479382 0.876825450322796 0.478574402545955 0.331161644030246 0.680102049731831 0.196227799705107 0.519022082221429 0.290378799998077 0.238766169795227 0.486606599703184 0.0744382636698862 partial_or_other True False False False True False True 2 residual_state_candidate +CCT8 0.119149448916677 0.644935614211487 0.877637712179418 0.536194794541049 0.025729618311623 0.351427309358494 0.0433258072869889 1.0 0.38383819420764 0.296268719967983 0.210061301039822 0.490222053010812 0.593899495247462 0.0836848617814314 partial_or_other True False False False True False True 2 residual_state_candidate +PDE3B 0.26912568073223 0.646530521873817 0.878181261125682 0.0739106115731082 0.899904402241766 0.968057977213875 -0.944269464660895 0.0222897731671553 0.295066443449176 0.393705640621835 -0.649203021211718 0.0804216787755617 persistent True False False False False True False 2 cross_species_direction_conflict +ADGRD1 0.274864269379595 0.647383994544087 0.878480422510034 0.0040213279816756 0.993721006057084 0.998542598236847 1.9839970566491 0.0870158937664957 0.0395169735252829 3.0 -1.9185248598599 0.0079932815889539 -0.196126356246399 0.753618139547397 -2.1146512161063 0.0065314512951213 persistent True False False False False True False 2 cross_species_direction_conflict +LZTS3 -0.194630226217104 0.651154389757242 0.87981674520821 -0.22547498481873 0.600066085233326 0.843257280459236 -0.818198262649693 0.0190656622159569 -0.331284377787189 0.26192288460731 -1.14948264043688 0.0052530463762208 persistent False False False False False True False 2 insufficient_or_context_specific +SLC13A3 -0.118672560218306 0.652010966481354 0.880523379906644 0.122721137997447 0.628766627246898 0.858472266510466 -1.45640345059709 0.0077315589540995 0.405345625855042 0.353495563686421 -1.05105782474205 0.0298248636211815 persistent False False False False False True False 2 insufficient_or_context_specific +PIR 0.119800323227992 0.652391899588145 0.88066344985361 0.0385084502172389 0.885214800922785 0.963081098449005 0.274732447731448 0.408982814243201 0.44702816889228 0.0955982205359399 0.721760616623728 0.0267794004284863 partial_or_other True False False False True False True 2 residual_state_candidate +VPS35 0.0846519688319264 0.65244833346798 0.88066344985361 0.222881582415871 0.230969846254646 0.601518427890281 0.142106173010226 0.714168325030578 0.625981319673356 0.039110718478162 0.768087492683582 0.0262945195472359 partial_or_other True False False False True False True 2 residual_state_candidate +PLIN2 0.20301728604235 0.654384207864392 0.882486711793619 0.279458599612775 0.5386291386828 0.812290593659906 0.8797165364212641 0.6716603526161391 2.0 0.426951953401942 0.246115647497672 0.486550562720016 0.132686146105763 0.913502516121958 0.019553149402753 partial_or_other True False False False True False True 2 residual_state_candidate +PNO1 0.177182737821083 0.656906703155536 0.883503625629006 0.0102941534601559 0.977602032343004 0.993500350721674 0.0211610009469439 0.972359389930452 0.835713762072826 0.0368939149261647 0.85687476301977 0.0548933696540216 partial_or_other True False False False True False True 2 residual_state_candidate +RBBP8 0.178356340712045 0.657450434234269 0.883503625629006 0.0389266925465224 0.92105481098156 0.97652542797714 -0.780819116864131 0.0530084782743035 -0.499208501833803 0.165491659434131 -1.28002761869793 0.0072723956598641 persistent True False False False False True False 2 cross_species_direction_conflict +RAP1B 0.0701673385214342 0.657500600931171 0.883503625629006 0.119420328935816 0.446763057050372 0.761469121135878 0.219071498063709 0.405405936924702 0.261704771454517 0.232284281291996 0.480776269518226 0.0520900391262909 partial_or_other True False False False True False True 2 residual_state_candidate +PATJ 0.109366174696362 0.661580238932143 0.884956817768348 -0.0541788781017156 0.831599000140922 0.944291486716267 0.4450255605286379 1.0 -0.675429423722145 0.0212177934030192 0.104631056151609 0.682011213899072 -0.570798367570536 0.0386358061808482 persistent False False False False False True False 2 insufficient_or_context_specific +AFDN 0.0805584245724807 0.663177810383749 0.885576036356938 0.111877368792128 0.546113726184956 0.81552807024429 0.299908822072062 1.0 -0.544479512156717 0.0519992319569476 -0.143562273097664 0.56186391710334 -0.688041785254381 0.0192902393179619 persistent True False False False False True False 2 cross_species_direction_conflict +SUMO2 0.0912539215090003 0.664772779626135 0.886755654743239 0.0135873694335024 0.947520948529936 0.986094250821001 0.521046121433266 0.4268538342935639 2.0 0.742228852257424 0.121810942526137 0.701260707641111 0.0524014625971923 1.44348955989854 0.0071915727806432 partial_or_other True False False False True False True 2 residual_state_candidate +ATP6V1A 0.0725309183606817 0.667822463543446 0.887571698148502 0.115103280673442 0.491459693819788 0.785509848901139 0.22035154627036 0.496921024026562 0.285434886746705 0.269302067855495 0.505786433017065 0.0812147279507778 partial_or_other True False False False True False True 2 residual_state_candidate +RER1 0.0683030745054912 0.66941321443441 0.888521880212043 0.119874843041666 0.45691082654023 0.767429924691655 0.8264106219365409 1.0 0.117108627068703 0.749781613072836 0.387645382603814 0.158799261918947 0.504754009672517 0.0896929306427283 partial_or_other True False False False True False True 2 residual_state_candidate +ARPC5 0.10558961046694 0.670133680621676 0.889076577029863 0.148182389186325 0.548314319736064 0.816156774016399 0.0794725633487231 0.804735108155807 0.406413352855481 0.0786574399479916 0.485885916204204 0.0566597396721633 partial_or_other True False False False True False True 2 residual_state_candidate +DHRS7 0.140574992332407 0.671596363576986 0.889898896416393 0.459222617404455 0.200886646844669 0.575963156173919 0.339237139524565 0.252689346597304 0.514953633011239 0.0441364525005086 0.854190772535804 0.0095398965625757 partial_or_other True False False False True False True 2 residual_state_candidate +ARL1 0.161071558425709 0.673143748742868 0.890384828267001 0.391901470297061 0.308234162208178 0.662330926800867 0.131974185405464 0.761247059790319 0.720367337723259 0.0303985813323003 0.852341523128723 0.0239586030797974 partial_or_other True False False False True False True 2 residual_state_candidate +ARRDC3 0.202402601437917 0.67679791249482 0.892311733281756 0.0143934886772065 0.974965767070174 0.992692094136128 0.102525751226435 1.0 0.282587709009512 0.68494070101762 0.687430085984779 0.190995784564309 0.970017794994291 0.0940117183479661 partial_or_other True False False False True False True 2 residual_state_candidate +FGL1 0.11093337734759 0.677743935645091 0.892461217295681 0.250910536472554 0.337257595252372 0.685057785656405 0.911295275604944 1.0 -1.52841457668023 0.0095657345050797 -0.608194937089289 0.199539209155658 -2.13660951376952 0.0033388329410027 persistent True False False False False True False 2 cross_species_direction_conflict +WDR91 0.152528177078476 0.677985525778474 0.892461217295681 -0.183285473223691 0.610238114125812 0.848355438906531 -0.819209529039641 0.0204325629355506 -0.271054227118533 0.364397335153625 -1.09026375615817 0.0066779672868489 persistent False False False False False True False 2 insufficient_or_context_specific +CGGBP1 0.0733806772337617 0.67919520163297 0.892846820514997 0.197216713133123 0.265736162164906 0.62822323708046 0.0681723558152978 0.84336036558253 0.393026497740568 0.106162430097961 0.461198853555866 0.0798648203312003 partial_or_other True False False False True False True 2 residual_state_candidate +SLC44A1 0.0941199984650007 0.681974878580184 0.894320327061556 0.0799341806340651 0.728105747861014 0.90383360582551 0.893657976736442 1.0 0.265795792256971 0.296797026650189 0.36974944427758 0.0910857986325187 0.635545236534552 0.0178433403612881 partial_or_other True False False False True False True 2 residual_state_candidate +DNAJA2 0.0955688773166025 0.682565128587432 0.894442426166824 0.0029671110155664 0.988909161743971 0.99674490975588 0.175538764111835 0.542888424064452 0.273068342551519 0.2408592838126 0.448607106663354 0.0800449285046981 partial_or_other True False False False True False True 2 residual_state_candidate +PLXNA2 0.0897602990661843 0.68518554517227 0.895504193299869 -0.0010338976089871 0.996307922082903 0.998795540446485 1.04638141875223 0.166189190227683 2.0 -0.933219000175874 0.0277712967534047 -0.142249994743115 0.710240416469499 -1.07546899491899 0.0158491188301678 persistent False False False False False True False 2 insufficient_or_context_specific +KLF12 0.0749113138510521 0.685835092538619 0.895504193299869 0.311432010901225 0.0832504328574142 0.464737806591834 -1.27924749953913 0.0001552535126234 0.610705000521086 0.0091920347644963 -0.668542499018045 0.007942431890179 persistent True False False False False True False 2 cross_species_direction_conflict +SAA1 0.268991300142253 0.689927313980537 0.897610409140063 0.316664595412815 0.640102408138841 0.864640237429136 -5.89025081931059 0.0092001701561049 -0.856800690895311 0.586891756637834 -6.7470515102059 0.0070961828862888 persistent True False False False False True False 2 cross_species_direction_conflict +SLC25A25 -0.171495017125699 0.690876589287361 0.897801418588806 -0.132304438343184 0.759020060589069 0.915406319729464 0.378482965814957 1.0 -1.45602952080327 0.0025660399388253 0.595590148414178 0.0961510842298932 -0.860439372389096 0.0304248343175407 persistent False False False False False True False 2 insufficient_or_context_specific +SEC16B -0.196172886320133 0.704953921620324 0.902846701052284 -0.269412118963668 0.602871871178661 0.844964982862645 -0.550059273160425 0.0683464835535966 0.065609522798357 0.819046154723282 -0.484449750362068 0.0879042255519897 persistent False False False False False True False 2 insufficient_or_context_specific +RETREG3 0.079586723857179 0.71064033378095 0.904731779097946 0.0368680520266345 0.861671756417857 0.957822965712685 0.678270168130176 0.423413358532747 2.0 0.127500875079742 0.608683178790114 0.443292683779446 0.0358926155135415 0.570793558859188 0.018467387351814 partial_or_other True False False False True False True 2 residual_state_candidate +PACS1 0.125930165627303 0.712361714613217 0.905176914536809 0.226102288147433 0.51112107533173 0.796519013040946 0.8674825783162191 0.575904045658756 0.209192841988119 0.173324346422386 4.0 0.0153659724933457 0.976123528656896 -0.0248868287957249 0.947549942966529 -0.0095208563023791 0.984222118566733 partial_or_other True False False True False False True 2 insufficient_or_context_specific +GAB1 0.116807310596104 0.716476145859163 0.90727531439417 0.131337745998801 0.682710502758227 0.882074824865184 0.298248002168306 1.0 0.334702832710909 0.225535190100696 0.287709852476591 0.223784886603898 0.6224126851875 0.0276676116081117 partial_or_other True False False False True False True 2 residual_state_candidate +ERBIN 0.0666161860392954 0.723032013961937 0.911060031436941 0.270427697483939 0.15295345746715 0.536485533522497 0.296354712122463 0.192262956520762 0.530319483743053 0.0164100565453241 0.826674195865516 0.003903950913563 partial_or_other True False False False True False True 2 residual_state_candidate +PLK3 -0.158639332588293 0.729640744290406 0.913067082875205 -0.296944211754393 0.509879930703189 0.796465794993973 -2.31681596884964 0.0105890096229154 0.280469756372898 0.714273683685777 -2.03634621247674 0.019553149402753 persistent False False False False False True False 2 insufficient_or_context_specific +EPHB1 -0.121603445538673 0.738680283745911 0.916387651385983 0.162260385610154 0.652865636312349 0.870374832458737 -2.70889264386383 0.0037106656161797 1.12814407604887 0.143360777460151 -1.58074856781496 0.0279310423149252 persistent False False False False False True False 2 insufficient_or_context_specific +SERPINE1 0.333740363588404 0.73954843582452 0.916661712009929 -0.198121829658223 0.843923528394648 0.950868579539813 0.892094707572702 0.90534454753538 0.499674205071944 0.204289491139215 4.0 0.961701306422616 0.375872209667794 -1.48260095483624 0.107640497622777 -0.520899648413622 0.639697984928692 partial_or_other False False False True False False False human spheroid knockdown; HSC-specific mouse knockout/pharmacology 2 insufficient_or_context_specific +ARHGEF12 0.0501025626739893 0.742753091213853 0.917593417567984 -0.0612768989022614 0.691384629825038 0.885824849193387 -1.34668263492511 0.0302107148388683 0.137166164973885 0.810076073594949 -1.20951646995123 0.0405200692751443 persistent False False False False False True False 2 insufficient_or_context_specific +HIVEP2 0.0869116935416094 0.742790787794214 0.917593417567984 0.208429707625959 0.429072587390866 0.748336221434264 0.0656299965249532 2.76418843076839 0.0872574438064054 0.094171986204018 4.0 0.0649583301001355 0.90640223037438 0.355543973509509 0.311461533514656 0.420502303609645 0.279786045288159 partial_or_other True False False True False False True 2 insufficient_or_context_specific +ANGPTL2 0.119177949938097 0.748225033038104 0.919189349632913 0.607582235625747 0.110357991859238 0.487310613989892 0.7894831706079442 0.3775062163817679 2.0 0.242013841249453 0.454271077386481 0.928817157314732 0.0061345825413023 1.17083099856418 0.0036125669112409 partial_or_other True False False False True False True 2 residual_state_candidate +HSDL2 0.083211717297852 0.750468617008682 0.919855385136123 0.113222304997958 0.66428061375403 0.874498094764969 0.247073497070162 1.0 0.270507310961545 0.601947607941229 0.633940083933345 0.123868293097692 0.90444739489489 0.0499936448167263 partial_or_other True False False False True False True 2 residual_state_candidate +NPY1R 0.107547769362319 0.751083894477386 0.919855385136123 -0.0302867478838863 0.928764797303255 0.979458588812811 -3.14775262200372 0.0123199283374411 1.38623365801605 0.24440272578641 -1.76151896398766 0.060713838455481 persistent False False False False False True False 2 insufficient_or_context_specific +ADRA1B -0.135010410924357 0.75178788885072 0.919922577799954 -0.314102505621844 0.455344779944791 0.766628956571057 0.242844657914504 0.264045259645974 2.0 -0.706042555008298 0.0121357494829551 -0.0748367701948256 0.760575555362796 -0.780879325203124 0.0088333672976549 persistent False False False False False True False 2 insufficient_or_context_specific +PAQR3 0.102345918376652 0.752305250248027 0.919922577799954 0.10743906740152 0.740964790694206 0.908406208990048 -0.932185746673521 0.0596647669427486 0.0792838660781323 0.87262282113695 -0.852901880595389 0.0674746664648412 persistent True False False False False True False 2 cross_species_direction_conflict +SLC16A7 0.11834324229662 0.763044261069428 0.924611053857767 0.225482457447423 0.565190002846243 0.823754286312897 0.411189513933401 0.586880747018774 1.45707177393039 0.0117206812025629 1.86826128786379 0.0096186535801376 partial_or_other True False False False True False True 2 residual_state_candidate +KYAT1 -0.0770030815133687 0.764299203526601 0.925291937946778 -0.169222290240003 0.508626220518217 0.795448916639214 -1.1934874044743 0.0022738189136315 0.0424683149637131 0.897930508805421 -1.15101908951059 0.0041337545199723 persistent False False False False False True False 2 insufficient_or_context_specific +CACNA1D -0.128319866482738 0.777034432531915 0.931098226417468 -0.0439028052275817 0.923383021927102 0.978003851842718 0.76597772878625 1.0 -2.45835262307856 0.0032349170501253 0.622165417508647 0.378038302944677 -1.83618720556991 0.0117330402356381 persistent False False False False False True False 2 insufficient_or_context_specific +PKDCC 0.0835302785955852 0.783224381296988 0.933597104428259 0.203828653945215 0.506873942595747 0.793884451257365 0.4255710016676599 0.289982210219014 0.189716096053312 3.0 -0.518442360937552 0.0668566954029705 -0.0584457058927847 0.829448798472758 -0.576888066830337 0.0390584644465845 persistent True False False False False True False 2 cross_species_direction_conflict +ZFAND4 0.0676823437007948 0.787489733826716 0.934842185900527 -0.0338749967864658 0.892348921187493 0.965368150296491 -0.794486741141099 0.0281944008197415 0.230058427301474 0.451522787434133 -0.564428313839625 0.0849931931615046 persistent False False False False False True False 2 insufficient_or_context_specific +ZCCHC24 -0.0614440444044348 0.791935967508438 0.935936945981962 0.0539281794228848 0.819186830272026 0.937594977362923 0.751964053122897 0.3241576189939051 0.161949531434966 3.0 -0.735186111633409 0.0204522269653762 0.166816887027374 0.53542402004371 -0.568369224606035 0.0518605159057112 persistent False False False False False True False 2 insufficient_or_context_specific +PPIA 0.0654651672324702 0.796014989435154 0.937146103752939 0.229978141705374 0.366280593189949 0.707887999926555 0.454967281211906 0.242939381728188 0.600807245742389 0.0798366079297151 1.05577452695429 0.0136039913162424 partial_or_other True False False False True False True 2 residual_state_candidate +RAB3IP 0.101906853371795 0.796502973372403 0.937254065233556 -0.268247115362635 0.505096470429668 0.792832263802515 -0.540086716127364 0.0930187180352344 0.0389706371639822 0.90528533119947 -0.501116078963382 0.097437094799631 persistent False False False False False True False 2 insufficient_or_context_specific +NEDD4 0.0553183346131961 0.802484454576394 0.939291254044972 0.0406847106117051 0.854086490608831 0.95526155065304 0.274207480465917 0.277621657384023 0.25375785888125 0.245455170235624 0.527965339347167 0.0353316563669481 partial_or_other True False False False True False True 2 residual_state_candidate +IP6K2 0.0459697722380283 0.8077197315158 0.941501729036807 -0.156019494285456 0.417982907244134 0.7397022351129 0.5636979959033199 1.0 -0.712566281638005 0.0319831608342595 -0.563756904692195 0.0610256644262438 -1.2763231863302 0.0033388329410027 persistent False False False False False True False 2 insufficient_or_context_specific +AKAP6 0.0729208411002413 0.809969811328737 0.941564817022646 0.0222620393265757 0.941250427874679 0.984111856389759 0.78845578032107 1.0 3.30495173124071 2.38853787780033e-05 -2.00074383580326 0.0002767098815796 1.30420789543745 0.0137331819434486 reversed True False False False True False True 2 residual_state_candidate +CRYGS 0.063728593503063 0.810559066292748 0.941564817022646 0.187387296510063 0.479016856880734 0.779556053240451 2.08628983847836 0.169693443777642 1.29114992121368 0.073035685932538 3.37743975969204 0.0135257574085409 partial_or_other True False False False True False True 2 residual_state_candidate +NRIP1 0.0628558968792724 0.81192624313137 0.942530761405278 0.0373423277400774 0.887936572438399 0.964092382949879 0.9617233188234849 0.0506451091362446 2.0 0.365500832613904 0.327763013580976 0.429309633175385 0.157329812963542 0.794810465789289 0.031104344860037 partial_or_other True False False False True False True 2 residual_state_candidate +UQCC1 -0.03275963420395 0.822102939207177 0.946029511818221 -0.150227190989937 0.331134796977782 0.680102049731831 -0.700630859800694 0.0188256587310321 -0.0079751552456048 0.978321864408441 -0.708606015046299 0.0187211340471972 persistent False False False False False True False 2 insufficient_or_context_specific +INPP4A -0.0385852391191748 0.830290552497993 0.947390862776809 0.0962413243331648 0.582756958465588 0.833609818902975 -0.599038600308929 0.0231730146563341 -0.0573011584491549 0.811619804244142 -0.656339758758084 0.0161701382436796 persistent False False False False False True False 2 insufficient_or_context_specific +SPRY1 0.0731382478063726 0.83167038314491 0.947606925285218 0.07732898252866 0.822235638742781 0.938808681069134 0.719518024528718 1.0 0.18804531927553 0.59444055184476 0.530448932615522 0.0731128445739084 0.718494251891052 0.0298131918658172 partial_or_other True False False False True False True 2 residual_state_candidate +USP54 -0.0510479392037225 0.832177015487936 0.947699809030485 -0.0964037264786306 0.690024920861711 0.885210584988815 -0.595285326644928 0.0794196334667497 -0.10380468137749 0.743147095504934 -0.699090008022418 0.0390584644465845 persistent False False False False False True False 2 insufficient_or_context_specific +ST6GAL1 0.0645938234091443 0.834943183257478 0.948225126875272 0.009290869713133 0.976136162597424 0.992970766113577 0.6175820923697829 1.0 0.274709259021322 0.485551835343311 0.378930219798765 0.221318238808808 0.653639478820088 0.0658958178693273 partial_or_other True False False False True False True 2 residual_state_candidate +ASAP3 0.0524965015100336 0.8354099254214 0.948225126875272 0.13822089115651 0.588247410175167 0.835590841220889 0.0554922244459335 1.0 -1.00861249680227 0.0458710640396627 -0.6687675588826 0.141821091039445 -1.67738005568487 0.0061222386305539 persistent True False False False False True False 2 cross_species_direction_conflict +IL18R1 0.100942482416001 0.838630217921416 0.949063086873091 -0.0254322463743565 0.958823612695079 0.988310036398969 0.085511829727859 0.106485288340311 2.0 -3.42474165680079 0.0009297202687019 0.218991201129641 0.791939505073795 -3.20575045567115 0.002586236115289 persistent False False False False False True False 2 insufficient_or_context_specific +PDIA3 0.0555325535773661 0.844541069207529 0.950376610463724 0.12831692294319 0.649423875569969 0.869246612356457 0.0957486132775441 1.0 0.0893734115738752 0.860184763130935 0.882380138371961 0.0256409889087585 0.971753549945836 0.0225896267849194 partial_or_other True False False False True False True 2 residual_state_candidate +TDRP -0.0361397540712649 0.845283523528148 0.950376610463724 -0.133583843582697 0.477983683698814 0.778545319644225 -1.27620269929036 0.004038132209842 0.340856396334463 0.314094347868303 -0.935346302955897 0.018581432403435 persistent False False False False False True False 2 insufficient_or_context_specific +LPIN2 -0.0340901398072241 0.845455078584587 0.950376610463724 -0.14503741441055 0.433792930633941 0.751660242498796 -1.32483465079229 0.0231696895801545 0.412598565038987 0.397842671903549 -0.912236085753305 0.0819046985735267 persistent False False False False False True False 2 insufficient_or_context_specific +CCDC149 -0.0419340613817589 0.847596079547784 0.950376610463724 0.172536494271047 0.436950780090167 0.754304502320469 -1.27346461324819 0.0144271318522095 -0.528395600749713 0.24254509971149 -1.8018602139979 0.0041412353303569 persistent False False False False False True False 2 insufficient_or_context_specific +SNX29 -0.0233924681289092 0.853685662141585 0.951655796828666 0.0208196501647186 0.869752983785666 0.958502690861149 1.21047905470922 0.3116609358970661 0.012907077040704 3.0 -0.63463847995866 0.0647319282805759 -0.22234479428167 0.462516167664579 -0.856983274240331 0.0190626030269611 persistent False False False False False True False 2 insufficient_or_context_specific +RBM19 0.0368304354193006 0.853689268695146 0.951655796828666 -0.144926562456891 0.448800317917443 0.763278633468486 0.0242543893217553 1.0 -0.501026375059266 0.0782240189594798 -0.130836314380133 0.608209733626811 -0.631862689439399 0.0297616020955191 persistent False False False False False True False 2 insufficient_or_context_specific +SAMD12 -0.0690340643571371 0.859695959912045 0.954454647801799 -0.0601622397987498 0.877736183641407 0.961221722527329 -2.69014158217469 0.0293805258858397 -0.504381977066816 0.742934423784103 -3.19452355924151 0.0186445479755453 persistent False False False False False True False 2 insufficient_or_context_specific +UBA1 0.0347982696004421 0.861196099056922 0.954692262146729 0.0525538475375871 0.791510532420661 0.927588847807277 0.374617460032544 1.0 0.0331524210134378 0.931049044353546 0.498988900536039 0.0619234127648967 0.532141321549477 0.0600338030233721 partial_or_other True False False False True False True 2 residual_state_candidate +CADPS2 0.0429146915583212 0.863780134558881 0.955141241949026 0.203150331336786 0.415184922994729 0.737098102737237 -1.76895251265141 0.0151909678474645 0.293884365947918 0.665557838069379 -1.47506814670349 0.0279405435141411 persistent True False False False False True False 2 cross_species_direction_conflict +EPB41L4A 0.0444735013275124 0.870359761871081 0.957923448188657 0.0851812355372351 0.753523846006556 0.913602082065829 -2.40204461706387 0.0049927811393144 -0.0754720865587932 0.936077834746477 -2.47751670362266 0.0061077930728689 persistent True False False False False True False 2 cross_species_direction_conflict +ZMPSTE24 0.0338390132078409 0.870392907618828 0.957923448188657 0.102412053153648 0.622151770366181 0.854851430443277 0.227293254816538 0.421137587435773 0.471726378821636 0.0550081036897018 0.699019633638174 0.0168263090542282 partial_or_other True False False False True False True 2 residual_state_candidate +SP3 0.0272148848341256 0.872493996354125 0.957923448188657 0.092909639516229 0.582919050799993 0.833711641607468 0.3394017077853581 0.438418288587296 2.0 0.239417775135084 0.420901824876138 0.245986125326804 0.315838499466496 0.485403900461887 0.0761110811469107 partial_or_other True False False False True False True 2 residual_state_candidate +BHLHE40 0.0870098175874916 0.873068243981394 0.957923448188657 0.228795280385482 0.677600695245689 0.879886294337383 0.0388018213438916 0.94120823747237 1.00049070989022 0.0132242980310499 1.03929253123411 0.0166736033483081 partial_or_other True False False False True False True 2 residual_state_candidate +APBB3 0.0652233842254507 0.87588492549521 0.958929339185136 -0.160489611546337 0.697371144448522 0.888803059281445 -0.649753103361037 0.0933305604830216 -0.0482683734126106 0.903296706010674 -0.698021476773647 0.062290902625138 persistent False False False False False True False 2 insufficient_or_context_specific +CD2AP -0.0200832991579666 0.888427092754469 0.96289421911231 0.0916088409398236 0.522932210809518 0.80318857749882 -0.662536184039748 0.071655935407703 0.0394048696927766 0.916891833145961 -0.623131314346971 0.0752347470231496 persistent False False False False False True False 2 insufficient_or_context_specific +SLC37A1 0.0385961989600332 0.891582000764546 0.96428219259087 0.16031420267781 0.57129303864946 0.826941582404853 -1.25920811955921 0.0249448376855332 -0.438114469760227 0.401749684391482 -1.69732258931944 0.0086311159331162 persistent True False False False False True False 2 cross_species_direction_conflict +AP4E1 -0.0267099275938425 0.89364344292357 0.96522633968154 0.102511052966685 0.613515802361754 0.850400399282578 0.276044784338401 1.0 -0.957202428551564 0.0577091094285948 -0.329384321758916 0.460642176317562 -1.28658675031048 0.0175044721399198 persistent False False False False False True False 2 insufficient_or_context_specific +ABCA2 0.0310222289131942 0.897349389247351 0.966901529562418 0.0575446901604761 0.811924733660738 0.934063202799411 -0.794951867060897 0.022784208387205 0.0724853568517457 0.820117494103997 -0.722466510209151 0.0313324864278656 persistent True False False False False True False 2 cross_species_direction_conflict +TXNL4A 0.0275863985053137 0.899753648255972 0.966996040341054 0.0601827159183873 0.783868097226971 0.925218487481538 0.331749682681324 0.434800074868626 0.301544492326174 0.362568393658862 0.633294175007498 0.0955842678851716 partial_or_other True False False False True False True 2 residual_state_candidate +TET2 0.0225692951353479 0.908521384727626 0.970256333202762 0.105917737796207 0.58842753404786 0.835590841220889 0.0548153527109879 0.895309895664305 0.667403516100158 0.0259922179534556 0.722218868811145 0.0280469397924125 partial_or_other True False False False True False True 2 residual_state_candidate +CARNMT1 0.0250929184069886 0.913550606526474 0.97241584900996 0.206851582277869 0.357612797041344 0.701288497271586 0.490421013274681 0.430631364048113 0.752504030369626 0.0785031474596826 1.24292504364431 0.0296738774093425 partial_or_other True False False False True False True 2 residual_state_candidate +RSBN1L -0.0212098412472746 0.914190801980415 0.972594365911852 -0.106601280540715 0.589943711014396 0.836894386999166 -0.568408158565393 0.0810532129341855 0.0151139586453317 0.964094552935472 -0.553294199920061 0.0754706606893775 persistent False False False False False True False 2 insufficient_or_context_specific +THSD4 0.0324524973985976 0.917203942571057 0.973181851556645 -0.301858787769648 0.317529350099392 0.669290253214092 0.430375526078866 1.0 -1.83036340297495 0.0203718553552959 0.548875284047701 0.41980923447149 -1.28148811892725 0.0639167376164073 persistent False False False False False True False 2 insufficient_or_context_specific +SLC4A4 0.0536375836414741 0.917349632024634 0.973181851556645 0.266830702740737 0.608479234112875 0.847936692532885 0.482339562859071 1.0 -1.18373391458459 0.0015484713424545 0.390612121143557 0.139125904119514 -0.793121793441037 0.0140727813547258 persistent True False False False False True False 2 cross_species_direction_conflict +GRAMD1C -0.036226601029814 0.918467633096786 0.973181851556645 -0.0753766862276696 0.829526180557044 0.942951917993246 -0.625676709041063 0.0424178927269605 0.101705192854837 0.712918752767113 -0.523971516186226 0.0687540680558783 persistent False False False False False True False 2 insufficient_or_context_specific +MFSD14B 0.0211270291294611 0.919174880776932 0.973291952426317 0.0291348327396993 0.888900030788047 0.964276699808303 0.10117389873453 0.719114304158739 0.489735609552395 0.0309928578466738 0.590909508286925 0.0215252001116873 partial_or_other True False False False True False True 2 residual_state_candidate +UNC13B -0.0210178704433908 0.92222026997441 0.974045030323348 0.0869483979964469 0.686814453857927 0.884207658069991 -1.58679503408759 0.0097137057032788 0.193305019895345 0.724953532262847 -1.39349001419225 0.0177910157506892 persistent False False False False False True False 2 insufficient_or_context_specific +RPRD1A -0.0147472741343009 0.929231093299065 0.977594884193597 0.0681046275041544 0.689180255598237 0.884999569552245 -0.739299066612223 0.05160313481357 -0.0791326321318526 0.825715637439822 -0.818431698744076 0.0306836091403109 persistent False False False False False True False 2 insufficient_or_context_specific +HELB -0.0227149429069574 0.936963371261649 0.981043634740153 0.0982636353385499 0.732045041786197 0.904431845923655 -0.955451631711015 0.0154809105588594 0.279939569056758 0.383912031028419 -0.675512062654257 0.0547258120835453 persistent False False False False False True False 2 insufficient_or_context_specific +BTBD7 0.0111582620569604 0.941404691604282 0.982504875364752 0.221292420516624 0.168365447307391 0.547956075931201 0.14325823242128 0.640930762307536 0.367347392014333 0.115266286226658 0.510605624435612 0.0552706649122925 partial_or_other True False False False True False True 2 residual_state_candidate +SERTAD2 0.0144194607193394 0.955529567521093 0.986654931577523 0.107784559533781 0.675051855805323 0.878580824298291 0.6077083994453439 1.0 0.178065391980456 0.552221557080533 0.393992937354435 0.0975789966571976 0.572058329334891 0.0370642054096256 partial_or_other True False False False True False True 2 residual_state_candidate +ANKRD50 0.0120606056166639 0.962572290461331 0.989894006954299 0.235905905282164 0.334651660681409 0.684340932301823 0.485861939285959 0.16796265374126 0.0687218354419558 0.832172632780718 0.554583774727915 0.0953082834648295 partial_or_other True False False False True False True 2 residual_state_candidate +AXL -0.0160627431028798 0.963370160420744 0.990096578771752 -0.135468328873021 0.692426371239153 0.886675273201089 0.76200487630973 0.380979404596113 0.211251579528561 0.0387936767866656 4.0 1.08822937358993 0.0022191009751728 -0.627043546569805 0.0248766700000946 0.461185827020122 0.0928380017138481 reversed False False False True True False False 2 insufficient_or_context_specific +DAD1 0.0100875802880403 0.964402385600892 0.990394632839926 0.0767467999790148 0.732934161178518 0.904431845923655 0.0083031031451725 0.987150167161135 0.622809682004934 0.0729066936551299 0.631112785150107 0.0833778130497341 partial_or_other True False False False True False True 2 residual_state_candidate +SNRPC 0.0131236349816265 0.967940285694268 0.991896878225767 0.0994778975143466 0.763078949936652 0.916866798061945 0.266227882878534 1.0 0.251175990309776 0.520860017236944 0.800749370680416 0.0163653546155145 1.05192536099019 0.0093579283120773 partial_or_other True False False False True False True 2 residual_state_candidate +TDG 0.0067378092239846 0.968371731222293 0.991953889419324 0.0062139310885317 0.970780473841977 0.992040338141303 0.76741692141956 0.205525374563396 0.481819563953986 0.252812291924551 1.24923648537355 0.0333116739372013 partial_or_other True False False False True False True 2 residual_state_candidate +ATOX1 0.0074516903743386 0.973417975522028 0.993652420531912 0.104918446962649 0.64743415219178 0.86855377695836 0.4622145769242439 0.949444263666146 2.0 0.214704424364508 0.550842004739652 1.01339040516592 0.0056542642085908 1.22809482953043 0.0038808768496921 partial_or_other True False False False True False True 2 residual_state_candidate +ABTB2 -0.0148790432184347 0.977920810899117 0.995841813413664 0.0324927122637061 0.951648225587167 0.986917609553614 0.4034257835113979 0.870895026217622 2.0 -0.676029414842198 0.0816555664296221 -0.26798001466468 0.437585833980489 -0.944009429506878 0.0223936058915012 persistent False False False False False True False 2 insufficient_or_context_specific +FBXO9 0.0041052262868052 0.979117126429543 0.996003335662695 0.0377849662499528 0.808746798537769 0.932859303825974 0.0605794982635804 1.0 -0.536244983352059 0.0691764284523579 0.0028501140186332 0.993127812172355 -0.533394869333426 0.0604551190265147 persistent True False False False False True False 2 cross_species_direction_conflict +GNPDA1 0.0071930609354089 0.979746149264935 0.996040674920114 0.297610287588276 0.338621672252501 0.686739841652306 0.565613408171819 0.228611703084623 0.25542342675509 0.487169703306988 0.821036834926909 0.0656999624831582 partial_or_other True False False False True False True 2 residual_state_candidate +CHD3 0.0060840799694938 0.983274672965838 0.997088076507116 -0.0711454272779545 0.807207510093096 0.932788199072101 0.965673236579085 1.0 -0.631646792799142 0.0335587687300548 -0.307142520299053 0.228045929904864 -0.938789313098195 0.0065290143385393 persistent False False False False False True False 2 insufficient_or_context_specific +IGFBP1 0.0121008500064835 0.98518089895165 0.997388466578742 0.091920573760816 0.894147677432638 0.966191860460739 -3.02273250864916 0.0034706989879636 0.738601364090933 0.314963404454446 -2.28413114455823 0.0140727813547258 persistent True False False False False True False 2 cross_species_direction_conflict +SIRT7 0.0028056527005053 0.988164935953793 0.997622899917553 -0.0359242834152455 0.922866876650479 0.97777552504144 -0.763620715489285 0.0233545280959134 -0.256324369643607 0.367719409150488 -1.01994508513289 0.0071915727806432 persistent False False False False False True False 2 insufficient_or_context_specific +CLTC 0.001710262516705 0.99215474794786 0.998248729595712 0.0955930344994121 0.576815847651276 0.83036368131276 0.482774018167571 0.126115776710102 0.263628769774115 0.322735225741053 0.746402787941686 0.0230719640101201 partial_or_other True False False False True False True 2 residual_state_candidate +MTHFD1L 0.0025271103018828 0.995177694076579 0.998868638976966 0.257158789583661 0.538923457511198 0.812502336770417 0.6183519718702359 0.380931118981134 0.341366154677572 0.173131353514588 4.0 0.846519713233635 0.382472796949351 -0.785287614363314 0.285315532335222 0.0612320988703203 0.955040456247959 partial_or_other True False False True False False True 2 insufficient_or_context_specific +FGFR2 0.0008982980726003 0.998607318662636 0.999547722001849 0.0759503415437908 0.882755045547268 0.962778177759102 0.628998429572044 1.1909972766747 2.0 0.448959769814918 0.135569077663801 0.210168549701499 0.424292367597128 0.659128319516417 0.0307890302402329 partial_or_other True False False False True False True 2 residual_state_candidate +CANX 0.0002384448834171 0.99921792969078 0.999547722001849 0.216451199894501 0.321203544219754 0.672472248121257 0.133004674116481 1.0 0.235904948488082 0.444804183757297 0.624165127701564 0.0248766700000946 0.860070076189646 0.0097647150420757 partial_or_other True False False False True False True 2 residual_state_candidate +JDP2 -0.0002839879414955 0.99922930073138 0.999547722001849 -0.433463285882826 0.0951088785332341 0.475178240428531 0.246228758434493 0.509837328000701 2.0 -0.698032406441462 0.0385908394070961 0.0243353795835719 0.942395283913998 -0.67369702685789 0.0391192924005971 persistent False False False False False True False 2 insufficient_or_context_specific +APBB2 0.770365765699271 0.0024767854771507 0.201379514324843 0.500626720004755 0.0642888028098907 0.433713214100209 0.920809150715995 0.217057085573479 0.260214763037004 3.0 0.596593480101408 0.0399073676480606 -0.306744573881426 0.201863950398564 0.289848906219982 0.26921207916053 reversed True False False False False False True 1 insufficient_or_context_specific +YBX3 0.66432749736555 0.0027776873931046 0.209978919106319 0.470311527970598 0.0570734507804043 0.424455207563489 0.153335125381179 0.0886991069390942 2.0 0.591709407135211 0.0450170583303248 -0.521893204074963 0.0492055080849207 0.0698162030602483 0.816536064181449 reversed True False False False False False True 1 insufficient_or_context_specific +PLSCR4 0.671917954234436 0.0031377911132086 0.212953915711243 0.458234176192678 0.0594490810132344 0.428473540531152 0.558816662983974 0.585365037501947 0.145927768592309 3.0 0.0097355041279017 0.981835251826097 -0.118445509384885 0.702432699749086 -0.108710005256983 0.748842717312004 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IDS 0.737794711427086 0.003757800788719 0.21424167471499 0.453491812134195 0.0834706808738642 0.464779732481256 0.0395623326171423 1.0 -0.0230779551263618 0.963430545564608 0.780050895354157 0.0261001402017192 0.756972940227795 0.0432856996201377 partial_or_other True False False False True False False 1 cross_species_direction_conflict +GATA4 -0.729366595314122 0.0042164591462355 0.21424167471499 -0.352721446856481 0.220911078791653 0.5925760086083 0.298577351983903 1.0 0.424043066130062 0.0663323696670329 0.401222143105123 0.050881973646522 0.825265209235185 0.00401870946594 partial_or_other False False False False True False False 1 insufficient_or_context_specific +LMCD1 1.22343723879289 0.0042898827019865 0.215678959845589 0.491356166362751 0.288585489398329 0.648310091921223 0.625818883297125 0.5013890988231671 0.295403373520856 3.0 2.54861704851649 0.0076256387482014 -1.84975620237728 0.0108050520501676 0.698860846139211 0.448141635453421 reversed True False False False False False True 1 insufficient_or_context_specific +XIAP -0.461424997990504 0.0043171593781432 0.216021652675054 -0.32515777460805 0.0628825951162616 0.432999502601999 1.19602031393228 0.123021345733282 0.430346537985593 0.39561140610665 1.62636685191787 0.031164384562845 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PPFIBP1 0.811432776955597 0.0051253256572392 0.227474198558781 0.459894493968172 0.1267885068337 0.508384607335028 0.0751005767784445 0.106133604192245 2.0 0.535559750719929 0.0701128786372105 -0.59579780297308 0.0318907698878728 -0.0602380522531513 0.846352122428412 reversed True False False False False False True 1 insufficient_or_context_specific +RAPGEF5 1.01495294614806 0.0055032084837367 0.229265285907992 0.275974402713656 0.483727870195149 0.780666906162311 0.623460465291106 1.0 0.218404784233553 0.606365617580331 -0.174780941465409 0.617950902649055 0.0436238427681445 0.917935297903664 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FAM81A 1.42645333523437 0.0055298647131209 0.229265285907992 0.965400281229012 0.0671690899854515 0.436950863873319 0.0475581707506284 1.0 1.60780004979842 0.0223714810539564 -1.36638195209283 0.0171024123096465 0.241418097705592 0.75578304735078 reversed True False False False False False True 1 insufficient_or_context_specific +MDH1 0.677520784405821 0.0057469612049702 0.231589375580443 0.234144474532166 0.391615710337247 0.723478332413062 -0.579677142270196 0.219160304429967 1.59250881601211 0.0039566153281876 1.01283167374192 0.0325036856019341 partial_or_other True False False False True False False 1 cross_species_direction_conflict +NUAK1 0.97811911618441 0.0062721116363535 0.237387459486941 0.631238648427048 0.100123565213596 0.478125555523304 0.6063897919837321 2.09960679829391 0.0842513623950084 3.0 0.752371079056279 0.118388200332064 -1.05386695956755 0.0206487880574704 -0.301495880511272 0.536434278744994 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TSC22D1 0.871954680289769 0.0067495745376097 0.238334474809644 0.451575532106695 0.162012170445078 0.543541307772207 0.4259503129624461 0.170448686133215 0.155073726995978 3.0 -0.193436352088066 0.614987229899015 0.788962771741626 0.0216465274460034 0.59552641965356 0.0749495908906582 partial_or_other True False False False True False False 1 cross_species_direction_conflict +KCNQ1 0.92996610145989 0.0086568655915502 0.258189793546857 0.665514717012519 0.0622138670146211 0.431813959784778 0.520056170056759 0.0329330648728091 2.0 0.562934155280047 0.363186362938712 -0.430602641986122 0.36419680401427 0.132331513293925 0.841048909610906 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RUSC2 0.638168720157083 0.0090584632108985 0.258484471839641 0.419469095136026 0.105389745009118 0.482830329046451 0.197688911338331 0.75124346995672 0.0743137441945122 0.148883660005249 4.0 -0.255743855214724 0.464985416596068 -0.0614422903641728 0.850236270839346 -0.317186145578897 0.301761940458863 partial_or_other True False False True False False False 1 cross_species_direction_conflict +SERINC1 0.715856681094844 0.0093680852418294 0.259601690244713 0.499112409627241 0.0695739236234398 0.441118118691429 0.0810966939515495 1.0 -0.229412516793488 0.364257514533844 0.617702770414887 0.0138088049183473 0.388290253621399 0.0945496568857383 partial_or_other True False False False True False False 1 cross_species_direction_conflict +CCNC 0.566187972841644 0.0107068057062902 0.274073458004984 0.432150775172033 0.0574482333290865 0.424455207563489 0.0337220955544455 1.0 0.135816801698705 0.727211832266628 0.324183645538468 0.237320130655727 0.460000447237173 0.140357314862905 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RAD18 0.748221733994147 0.010836175312049 0.274073458004984 0.360654940124757 0.240373112197246 0.607434015935502 0.894204975452648 1.0 0.485653665126235 0.327857898736225 -0.415158972933259 0.299846454594085 0.0704946921929763 0.896869437755745 partial_or_other True False False False False False True 1 insufficient_or_context_specific +OCIAD1 0.402406613938819 0.0111721881579147 0.278513274565188 0.200454280166352 0.241529135593314 0.608725035015447 -0.252537049761425 0.344052453853886 0.799470879892327 0.0054451042448924 0.546933830130902 0.0351750185906873 partial_or_other True False False False True False False 1 cross_species_direction_conflict +CHIC2 0.719919474720697 0.0112148546016096 0.278513274565188 0.410710427294647 0.161417769487884 0.543541307772207 0.422212747785746 0.148370786937069 0.175782681928421 3.0 0.0799596933559564 0.840915112898908 -0.122936872205833 0.672605562477756 -0.0429771788498768 0.901500715374742 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EPM2AIP1 0.435711963168483 0.0115124193334894 0.280851197393928 0.181852736279132 0.325416046808293 0.674724889947951 0.348093497869134 1.0 0.298073448840653 0.340696064266725 -0.413135453940618 0.126243873965407 -0.115062005099965 0.709796057516431 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PDK4 1.68908148644683 0.012156620373279 0.286245226460756 0.943326967737735 0.160895464451153 0.543541307772207 1.21939158217408 0.222474578645971 0.274345306265515 3.0 0.264632724418339 0.686450352724831 0.0905973385331225 0.865903472186746 0.355230062951461 0.518867314710815 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DENND4C 0.561563786352122 0.0125493223525539 0.288661754680313 0.385202342711147 0.0881416160029951 0.468622105620855 0.467397084333782 0.454559517053768 0.0632533778701625 0.0762667263632349 4.0 -0.082234167924512 0.745713951986193 0.104049448903151 0.590924003128715 0.0218152809786394 0.927074750236329 partial_or_other True False False True False False False 1 cross_species_direction_conflict +DECR2 -1.35429726359149 0.0129317465669798 0.29096528436151 -1.04302852391898 0.0696062498332942 0.441118118691429 -0.373536364183417 0.185592657557296 1.05555540401987 0.0022054600468663 0.682019039836452 0.0206146056959444 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ISCU 0.686343903368885 0.0131810140635788 0.292253024645663 0.34279531110553 0.21679376440351 0.588559672042236 -0.472290647078384 0.145429855379514 0.973248316830963 0.0053570603459811 0.500957669752579 0.092933097315602 partial_or_other True False False False True False False 1 cross_species_direction_conflict +ERI2 0.690827506028161 0.0134410620460398 0.292253024645663 0.531553252377517 0.0641332836261925 0.433610060260339 0.0220614269152238 1.0 0.459584119741021 0.323630168411968 -0.962375166616114 0.0246079859153381 -0.502791046875093 0.272137553731606 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PLXNA4 1.10871874245941 0.0135313793556428 0.292253024645663 0.816146238806838 0.0712958263760259 0.445672785599811 0.385289618179865 0.599863334241021 0.267129305153213 3.0 0.169933873767156 0.664875881263502 -0.160278581461209 0.609326819114746 0.0096552923059469 0.981133691463894 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CLSTN2 0.934498627905333 0.0149835653652602 0.297043416491418 0.737176568252475 0.058516408620497 0.427554492882497 1.58095965842817 0.209025503662214 0.3516844796920011 3.0 0.659241965044822 0.44052413426319 -0.811090793605492 0.214202339991032 -0.15184882856067 0.872852290329566 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ERCC6 0.55808395090445 0.0162885887528319 0.299692671530782 0.267819473957651 0.255681523404905 0.620428757552053 0.0473116296014414 1.0 0.153084383730901 0.610573234533361 -0.245488289662904 0.293485298780139 -0.0924039059320035 0.739914349687052 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NPRL3 0.380325156400711 0.0167242165981482 0.299692671530782 0.284518053520899 0.0786171684254873 0.457322349441485 0.112338105473775 0.076452695744631 2.0 0.0389994932858037 0.918658847405116 -0.215113627273504 0.399183405604824 -0.176114133987701 0.534468606166106 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ETV5 0.953183312531917 0.0167698516961637 0.299692671530782 0.425133436659167 0.294520639137657 0.652324662738756 0.0341121029879729 1.0 0.319999556406442 0.281021927434226 0.115198930221507 0.651591968750741 0.435198486627949 0.112945634907123 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCNI 0.511698175549622 0.0169033176149965 0.299692671530782 0.35573191187658 0.106945527254356 0.483261130274234 0.3955087790450879 0.0825874817613584 0.0984069616538651 3.0 -0.0501301268280245 0.918029766464874 0.632360493800827 0.0642822572557801 0.582230366972802 0.0986351595234192 partial_or_other True False False False True False False 1 cross_species_direction_conflict +VDAC3 0.61429379706907 0.0178005346807479 0.306088021432144 0.519713216736712 0.0538733063043058 0.418231152912398 0.0154743215967794 1.0 0.189167211329352 0.610284310404512 0.104274879636168 0.72951318681034 0.29344209096552 0.346020114135014 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TBCK 0.446189526890019 0.0184890143264666 0.308385251700923 0.369421355216546 0.0534234943603945 0.41688488799486 0.0847995293661759 0.0755807244527371 2.0 0.342524442925856 0.268302181913368 -0.656898602951704 0.023761804765379 -0.314374160025849 0.280987785735446 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZC3H12B 0.437102173881508 0.0187479103209731 0.309473467285879 0.255846217485648 0.17750434795462 0.560266339523133 0.0804178214172217 1.0 0.524906580148492 0.603562155863719 0.173830637522946 0.80493776979174 0.698737217671438 0.407697038024731 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SP100 0.438927043878111 0.0188191581302951 0.309473467285879 0.339744031472081 0.0747906616924028 0.452862231765951 0.117606888422139 1.0 0.136684804164788 0.738059229929372 -0.447938694621018 0.155624471531877 -0.31125389045623 0.343744562407399 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SAP30 0.834052645338701 0.0192040624032426 0.311453903000669 0.606951759770226 0.0925785746218744 0.472460751419842 0.293038051860348 0.031533829955366 2.0 0.422522691194924 0.47982538411702 0.172485238579193 0.700188035316158 0.595007929774117 0.247597157603853 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DNAJC9 0.454068332666756 0.0198822389809529 0.313776799941556 0.37110632506 0.0574539884608655 0.424455207563489 0.4828921871499861 1.0 0.370642737740319 0.411613070834813 -0.0630105116453018 0.87933507358141 0.307632226095018 0.448743582703435 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACOX3 0.393436735049373 0.0200342959656558 0.314117964424248 0.295589425377193 0.0938079485048973 0.473887234600338 0.4362030731002789 0.466954539216651 2.0 0.0934742534978437 0.821674162719162 0.0568524032142265 0.861628794546181 0.15032665671207 0.651855554166488 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PIK3IP1 0.871165834288217 0.0209554466411719 0.31919574035472 0.591239589010709 0.109467676733371 0.485409378811817 1.58729201085203 0.0238722902908955 2.0 0.103451535325994 0.879379990100037 -0.434154965437706 0.337323298274376 -0.330703430111712 0.534436612684058 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CLASP1 0.406947260972934 0.021973828522612 0.325508705713526 0.25006426162148 0.168963367967847 0.548585831083667 0.132249686794262 0.604968023577395 -0.364443961588839 0.0817758607106054 -0.232194274794578 0.286319702684933 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM33 0.607861561242063 0.0224357074550561 0.325508705713526 0.42383218348903 0.122080103376026 0.5038394341269 -0.0279124824015845 0.941370940333227 0.639222195745647 0.0219988654517772 0.611309713344063 0.0354456469991529 partial_or_other True False False False True False False 1 cross_species_direction_conflict +UPRT 0.552166387538262 0.0231463057378898 0.326250774279766 0.367224546881576 0.138276414600119 0.523810858054217 0.495031815890829 0.263111985856991 -0.476804797254912 0.191013197871587 0.0182270186359173 0.971277478566388 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GTF2H5 0.834721372135474 0.0235113357371834 0.327734533946059 0.507236183304105 0.167574299378769 0.547623080618609 0.670226635429084 1.0 -0.0724236035673504 0.85968155287448 0.683022340458137 0.0258302488325242 0.610598736890786 0.0519231343801239 partial_or_other True False False False True False False 1 cross_species_direction_conflict +FMN1 1.15034239635181 0.0235948013849913 0.327734533946059 0.592606420720476 0.239776546495168 0.606713331305531 1.12231066359033 0.101780364029071 -1.07521390740331 0.0619696300205183 0.0470967561870198 0.95257298514085 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RETSAT -0.581479103869981 0.0237439590090509 0.327734533946059 -0.427273451026681 0.107001629939493 0.483261130274234 -0.631859532459888 0.325940113374392 1.66737254155702 0.0119249432249266 1.03551300909714 0.084253654963768 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PPP1R16B 1.00344146490425 0.0239677298304603 0.327734533946059 0.385988107917542 0.369555062454727 0.709345639075664 0.366870605208847 0.495663579429938 -0.337196742201723 0.414520184003729 0.0296738630071245 0.957836295515167 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CDKN1A 1.2262787991546 0.0245446070478932 0.32844355033163 0.480103888945268 0.382918868741446 0.718602455771806 0.279022917338952 1.0 0.939588256318421 0.0223114204013783 -0.899888965057689 0.0184309366351925 0.0396992912607317 0.927074750236329 reversed True False False False False False True 1 insufficient_or_context_specific +CEP120 0.612556520759172 0.0248515707438204 0.330087379345907 0.209753770764581 0.46283435232397 0.769320698854699 0.9185705774894799 1.0 0.19860118986403 0.498404177312046 -0.341783056961236 0.151567302317096 -0.143181867097205 0.595332156027235 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TLE4 0.44619780551667 0.0254996168896583 0.330087379345907 0.245186855345904 0.257399374243835 0.621906676979798 0.184691795937432 0.716242594042539 0.0286204113751574 0.946491353563852 0.213312207312589 0.62406863118711 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BLZF1 0.486923800788946 0.0263609328418678 0.330935942403272 0.191444597159152 0.405238743075551 0.733444811508554 0.0615208759029096 0.8761579807827 -0.456644524303075 0.0967784960153306 -0.395123648400165 0.183047030507167 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PNRC1 0.667228495808628 0.0266068384779266 0.331425407194067 0.548005877713215 0.0755596501373765 0.453930920096201 0.517665041036111 0.255569750817323 0.0822122548066895 0.0760608824684849 4.0 -0.753264278641518 0.0789497824640368 0.389418394283927 0.29868302916948 -0.363845884357591 0.352956736180375 reversed True False False True False False False 1 cross_species_direction_conflict +HDAC1 -0.452826739684865 0.0266822879442089 0.331425407194067 -0.341835508776593 0.103041873143295 0.479258192355465 0.340905674515111 0.222434667102831 0.226115696803916 0.333986223700702 0.567021371319027 0.0399399924262679 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CEP295 0.473219190229431 0.0269818746220818 0.333062456906093 0.242943601970244 0.287324486444082 0.647596455327388 0.293425931948448 0.52206945977619 -0.929424287116661 0.0248582586181397 -0.635998355168212 0.130500588194361 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GMPR 1.22508508620518 0.0272419418370649 0.333442469818192 0.354795427263786 0.522251739661592 0.802493649737605 0.255102909507618 0.0396528539885125 2.0 0.792257172301618 0.355672545587563 -0.200660497579298 0.75971659425036 0.59159667472232 0.459892908694598 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FAM129A 1.2714646551426 0.0275213419156968 0.333988882696468 0.0359232134680946 0.951698095533544 0.986917609553614 0.2419133593724311 0.120805500483118 2.0 0.0993903277965493 0.900788059830312 0.161040417074126 0.753618139547397 0.260430744870675 0.666043360827916 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GLCCI1 0.900840994562552 0.0276213226312936 0.33443339947385 0.098626020741558 0.814941839426383 0.935641141872961 0.12131960973573 1.0 0.308386831679847 0.419778143407304 -0.143602343609929 0.644782572979555 0.164784488069918 0.651357841503356 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RFTN2 0.949662010122121 0.0280748016178039 0.337217014198832 0.729363735111553 0.093645556719806 0.473775578029617 0.253885074614486 0.0798528125344544 2.0 0.713000981488895 0.075785805452977 -0.327112944074435 0.308624631277282 0.385888037414461 0.302205612265466 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SGK1 -0.991736538747791 0.0293489493882924 0.342393599603969 -0.85297374261369 0.0627780686818305 0.432999502601999 0.603518694360333 1.0 -0.424603553566599 0.326855370011508 1.09943551093217 0.0123704430192059 0.674831957365575 0.0927305143200296 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CACNB4 0.673744995630249 0.0294011016251162 0.342436744765113 0.571056685410701 0.0680203813588095 0.43786261079484 0.654607833758587 0.0249437018218381 2.0 1.81415133326805 0.0602956011349721 -1.30121547041928 0.0616497894244614 0.512935862848766 0.638465089413867 reversed True False False False False False True 1 insufficient_or_context_specific +SNX13 0.420418935464321 0.0297098542146443 0.342441747596305 0.369723870180841 0.0598323353854302 0.428473540531152 0.136756828291149 0.675926385250434 -0.480630358558405 0.0685766344139705 -0.343873530267256 0.204073422819747 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NEXN 0.854866398116473 0.030428300772892 0.345387673449279 0.217330925227333 0.612472586385596 0.850070404503632 0.117966909528521 1.0 1.42944983865918 0.0024376259986037 -1.1880626493572 0.0040703474791481 0.241387189301982 0.536396287887495 reversed True False False False False False True 1 insufficient_or_context_specific +AK6 0.628730798306409 0.0304853500823425 0.345387673449279 0.512203573464946 0.0830201648647881 0.464508161442731 0.0249512762348854 1.0 0.501724488944645 0.181626715567711 -0.470227509031243 0.136643678719353 0.0314969799134023 0.940014706726618 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RHOBTB3 0.598785503531799 0.0306883629006315 0.346514297436479 0.498726549840484 0.0756314733885016 0.453960827763388 0.111204603196955 1.0 0.572976780688886 0.184169650286794 -0.283334317581012 0.420595399064612 0.289642463107875 0.481158806127244 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HNRNPLL 0.454197976547063 0.0316436403029483 0.351677425598451 0.261368929772674 0.227051999538416 0.599153964290576 0.371409832820581 0.342578680355969 -0.372072592188062 0.259397665646443 -0.0006627593674813 0.999089144569744 partial_or_other True False False False False False True 1 insufficient_or_context_specific +YIPF5 0.801051549813133 0.0319920936128018 0.352489948368348 0.549623515551096 0.142580117293935 0.528011532230573 0.0343371910963479 1.0 0.0924952517335966 0.83289069999139 0.372738463694815 0.210004265652491 0.465233715428411 0.15407137918355 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SECISBP2L 0.361511617987842 0.0321659589227871 0.352695607872978 0.151901319545733 0.38195950459144 0.718125771636418 0.0682576922802024 1.0 0.0874609936521467 0.770644540823013 0.145273961829296 0.516655725454482 0.232734955481443 0.322267661503967 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NIT2 -0.661229465101387 0.0326716440002426 0.355262019067548 -0.34219274003571 0.300980228274603 0.658632920234719 -0.916348351063223 0.0471712316320222 1.78477536099517 0.0018200698421415 0.868427009931944 0.043236126308543 reversed False False False False True False False 1 insufficient_or_context_specific +BNIP3L 0.64548721815805 0.0326918170240092 0.355262019067548 0.551714313366854 0.0678019021630733 0.43786261079484 0.151337178740469 0.464403266351412 0.131369140175546 3.0 -0.570914038482098 0.243076272517788 1.86278242600418 0.0010862639430505 1.29186838752208 0.0085926215024744 partial_or_other True False False False True False False 1 cross_species_direction_conflict +SH3BGRL 0.709103046107237 0.0327722674804815 0.355262019067548 0.208188724035574 0.566154196932165 0.824113119711934 -0.0964522595603264 0.783657599834408 0.713464286661818 0.0152491184819162 0.617012027101491 0.035821133964753 partial_or_other True False False False True False False 1 cross_species_direction_conflict +EXOSC8 0.641378010208019 0.0328474083751735 0.355695320641109 0.223771891359902 0.461587784948209 0.769126302007068 0.196443278235374 0.559961874912392 -0.368537345090036 0.167786139537494 -0.172094066854661 0.571709963277122 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FRYL 0.385131492973315 0.0329033150974985 0.355893254125802 0.327222140510278 0.0718540110861786 0.446899163045108 0.280463743615258 0.305613434681187 -0.75986947664686 0.0080807149151296 -0.479405733031603 0.0707951770428376 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ITGAV 0.677434898572968 0.0329331037394307 0.355893254125802 0.591220531243394 0.0711804156838922 0.445392832914335 0.186602529059329 0.21603869351914 2.0 0.189330098699012 0.583165332079096 -0.0111560198839238 0.972450972033354 0.178174078815088 0.5572780050764 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RAI2 0.951355214706086 0.0334698855345068 0.356792055793388 0.807224420476026 0.0734641772179174 0.451738371034812 0.0904742963494231 1.0 -0.184283827917293 0.64876414120596 0.935376396309785 0.0084536844581115 0.751092568392492 0.0325697119413981 partial_or_other True False False False True False False 1 cross_species_direction_conflict +TCAF1 0.46077760133544 0.0343617413435255 0.362067130843256 0.257637795856547 0.246407343086394 0.611559754402286 0.106425149077246 0.105098626915914 2.0 0.461242667848515 0.125834635715537 -0.346069738904327 0.174591095652299 0.115172928944189 0.704885757533207 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATAD2 0.438991581896656 0.0348081441463253 0.363322396620508 0.0507661194299838 0.829353412848117 0.942947704141109 0.3260589937204461 0.0350158996667017 2.0 1.34042780937936 0.0666251688683871 -0.715887670479472 0.197369827353113 0.62454013889989 0.371904527132822 reversed True False False False False False True 1 insufficient_or_context_specific +SMC4 0.479049953769018 0.0351614904799805 0.363322396620508 0.331822581808681 0.156306064796992 0.539558215777 0.0499924381343597 1.0 0.790502016139376 0.0290741276135023 -0.545489343510088 0.0721530524052892 0.245012672629288 0.457478584434967 reversed True False False False False False True 1 insufficient_or_context_specific +SMU1 0.449737478344192 0.0354089497638146 0.363735489912958 0.253042854625514 0.249769623408533 0.615993385645244 0.148018609951812 0.598468161484001 0.180065853915951 0.414520184003729 0.328084463867763 0.16765676831985 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KDM1A 0.35301346441515 0.0355528687139669 0.364080686597539 0.324970139152561 0.0531040434551615 0.416631456505827 0.491845865573531 0.0427970014531638 2.0 0.141576660770813 0.700891843331861 -0.12747363911946 0.655314204671307 0.014103021651353 0.969702204130634 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ETNK1 0.375427532577936 0.0360362438693209 0.365949036346115 0.257565907631593 0.168718579540613 0.548101773166091 0.11974855459178 0.0899324152746984 2.0 0.0279305363829084 0.94006673503822 0.215783313505731 0.39078705830484 0.243713849888639 0.353789311339258 partial_or_other True False False False False False True 1 insufficient_or_context_specific +USP33 0.312465074257786 0.037125886528545 0.368139714899329 0.25668791359808 0.0889855969374257 0.470236852611986 0.0384359812342911 0.927411660875329 -0.746620870227054 0.0199850960145932 -0.708184888992763 0.0322700912634467 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ENSA 0.362656520492177 0.0374314043442932 0.368446063719788 0.137266145115721 0.474915478676098 0.777120670205378 0.386848726189518 0.647116598319245 2.0 -0.0479301995720146 0.8890677464436 0.50398272275663 0.0417793065073846 0.456052523184615 0.0769497813959028 partial_or_other True False False False True False False 1 cross_species_direction_conflict +NPHP1 0.722519899908249 0.0383205602431502 0.371182087199248 0.476457597430293 0.175300637411285 0.557192294943862 0.027446844062609 1.0 0.2505907075924 0.625942919662045 -0.446370616078177 0.25005374114053 -0.195779908485777 0.682044823034394 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HOXB3 0.515278240463413 0.0386114781443374 0.371584398994206 0.429182614210468 0.0863328877365846 0.467677448123587 0.469669633775884 0.01880437976085 2.0 1.09714853418106 0.0274094159494251 -1.20315211111051 0.0110008762761375 -0.106003576929449 0.840495777223964 reversed True False False False False False True 1 insufficient_or_context_specific +ADIPOR1 0.619370018423257 0.0387411965873754 0.371768175769319 0.412934679217213 0.158792846721537 0.543060696740211 0.147112821202909 0.76108394193102 0.166537175072919 0.661270568117103 0.313649996275828 0.413869113485365 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RGS7BP 1.14401198832024 0.0392579305616016 0.374084143383926 0.985230887009214 0.0792888225942782 0.459078388240937 0.3340819344773739 0.245148972459882 0.130269873141099 3.0 0.738804544007382 0.236632746680037 -0.323486827479657 0.502725831163938 0.415317716527724 0.489102669710199 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KDM5B 0.394819205066321 0.0414821651395369 0.38299091656975 0.358999797682893 0.0644094831925483 0.433921581835015 0.3746221072471421 0.0628487097254442 0.0668161964214283 3.0 0.246665799483621 0.399982142314586 -0.297905605789487 0.223427779778677 -0.0512398063058657 0.866463335669125 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CHST15 -0.483210542247066 0.0414985422007761 0.38299091656975 -0.424797690676847 0.0806754291648548 0.460700922547448 0.8251601382842859 0.8435594891580799 2.0 -0.0459991350056412 0.935124441427216 0.799817629069799 0.0468645146127524 0.753818494064158 0.0681155053322474 partial_or_other False False False False True False False 1 insufficient_or_context_specific +KLHL24 0.706587020304039 0.0418084312677053 0.383572450100128 0.273499191525555 0.450578867423987 0.763947905803589 0.0892454983026542 0.127848489085913 2.0 0.163896841237363 0.693226815838373 0.393972355588651 0.211560687208758 0.557869196826014 0.10610738150025 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SH3D19 0.586062154928982 0.042170949078759 0.383730849135154 0.36436788378415 0.219578243218589 0.592069212484543 0.514566446037704 0.499830340817134 0.26551556559025 0.219336378796367 4.0 -0.138602542032569 0.611241804832431 0.159304042060343 0.465787572977052 0.0207015000277738 0.939006637034126 partial_or_other True False False True False False False 1 cross_species_direction_conflict +WEE1 0.907714599231888 0.0423057363473295 0.383730849135154 0.229057309677682 0.626756085208497 0.857061216957504 0.8811337350518671 0.995877806795582 2.0 1.36227452623535 0.0667885641616118 -1.0453552415407 0.0726446515518451 0.316919284694648 0.692897547684162 reversed True False False False False False True 1 insufficient_or_context_specific +CCDC32 0.409867002239321 0.0428654998948419 0.383949763302995 0.293655304187035 0.153932975957256 0.536731955137619 0.0528120513960966 1.0 0.226200387440523 0.731556142006226 0.284435451315474 0.525706559833131 0.510635838755998 0.32567344768569 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PIEZO2 1.04341831445454 0.0430069461833469 0.383949763302995 0.91701474349741 0.0772970847745383 0.455668688469891 0.101198945682997 1.0 0.0841957671277787 0.850634666014012 -0.226195062890956 0.468164393562029 -0.141999295763178 0.691791576134424 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MLH3 0.387995670361795 0.0432399780921933 0.384202635045819 0.167183717434962 0.400168608351813 0.729997628255253 0.6884088035379329 1.0 0.493003128311775 0.224621605158029 -0.0845375522362971 0.81034042980142 0.408465576075478 0.278098076185403 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC16A3 0.943073827542274 0.0433631162181641 0.384202635045819 0.607433218246783 0.188399052666157 0.569295133958011 0.647460862591775 0.4308204971800879 0.0194451116547039 3.0 0.449695943556705 0.58323339009334 -1.45065893085048 0.0421625560289208 -1.00096298729378 0.209384326395718 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MPC1 -0.468120936818517 0.0437609360748153 0.385082844493601 -0.25373240707401 0.274859035277768 0.638427515212424 -0.355676534085959 0.275592398751362 1.41624056627136 0.0011435898187173 1.06056403218541 0.0058899884753839 partial_or_other False False False False True False False 1 insufficient_or_context_specific +UBE2H 0.553939671486772 0.0438097382271685 0.385131737054492 0.278105825323241 0.340442941561314 0.687922789857293 0.107069180302781 0.232068843162399 2.0 -0.0105214617002216 0.977456978032175 0.510546493149854 0.0524014625971923 0.500025031449633 0.0686230778426983 partial_or_other True False False False True False False 1 cross_species_direction_conflict +EXTL3 -0.469722872903842 0.0446613343258943 0.389376026269853 -0.436497113562097 0.0637367220976471 0.432999502601999 0.264695442708771 1.0 0.457929988096296 0.060725149951687 0.189656537296004 0.357309166074634 0.6475865253923 0.0142028962553017 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MTURN 0.566247157655605 0.0449760763043727 0.389380444063995 0.407240133298791 0.147140070126655 0.532796338690088 1.01568816964659 1.0 0.367058123481037 0.552544563701777 -0.43176842556375 0.349924004657725 -0.0647103020827124 0.920467789613865 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MTR 0.52542191399167 0.0450311087444252 0.389380444063995 0.476006454568864 0.071208856029494 0.445392832914335 0.4277248200884329 0.0903047665559877 0.0976161549674602 3.0 0.0434515703387798 0.914207919490254 -0.358560916658278 0.181612159512539 -0.315109346319498 0.272828644553694 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TYRO3 0.982835763813097 0.0455144534604988 0.391958890404524 0.454735365419385 0.353366411892947 0.697398977158885 0.4227467890013 1.0 1.56425952076888 0.085918258031457 -1.36565962013806 0.0576233234372189 0.198599900630816 0.856435874168073 reversed True False False False False False True 1 insufficient_or_context_specific +THOC3 0.525098261116072 0.0464141458244311 0.394593584128907 0.144586064852949 0.557316435953401 0.821101152222033 0.0851998638468275 0.835429293121354 -0.141855042313445 0.623825236931879 -0.056655178466618 0.874437990462605 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WASHC4 0.319966852845391 0.0473810527778967 0.396574544678809 0.273047282318332 0.0905949287679282 0.472234212482528 0.284793075664334 1.0 0.0557006322989207 0.880894926276994 -0.330578297725348 0.197685629993857 -0.274877665426428 0.314535004750728 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KRIT1 0.310372688963643 0.0473819611181633 0.396574544678809 0.149681616917399 0.364384160077795 0.705850610221272 0.220060690117879 0.54781422572657 -0.912401695814737 0.0103458073751722 -0.692341005696858 0.0451005059492276 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MED10 0.481960395190385 0.0477252168895532 0.396735650076082 0.36491132027127 0.138135903783881 0.523810858054217 0.148933078185225 0.612872257609593 0.0499010876932887 0.842961551024825 0.198834165878514 0.423492076100721 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EIF3L -0.358122934576441 0.0482775791430305 0.396735650076082 -0.321626586645548 0.0747675591814441 0.452862231765951 0.214267208031861 0.45584858329954 0.273584955001467 0.239615881413648 0.487852163033328 0.0639059475217298 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ADH4 -1.56659005350963 0.0483196825317435 0.396735650076082 -1.5060105118864 0.0582709240351573 0.42715254026823 -0.234427133352447 0.483509605781318 0.782119697511119 0.0142029568047563 0.547692564158672 0.0698930165493918 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SNTB2 0.309951212523337 0.0483383470119123 0.396735650076082 0.261642889241611 0.1005793577209 0.478125555523304 0.2965875208493161 1.0 0.423323200509418 0.180083542833906 -0.20658898154873 0.437413047808039 0.216734218960688 0.46605519304985 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LTA4H 0.500707540947138 0.0492942270421756 0.399082619839385 0.287506047057758 0.238835010807146 0.606415397271769 0.316753100299305 0.323630168411968 -0.127944609992879 0.651861647147555 0.188808490306427 0.531868571559532 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GNB1 -0.34627082991947 0.0499514692752064 0.399082619839385 -0.251112140349357 0.160231282168873 0.543541307772207 0.366420869885262 0.272691728666575 0.172637609254615 0.556825176857364 0.539058479139877 0.0866643651409392 partial_or_other False False False False True False False 1 insufficient_or_context_specific +LCP2 0.827108559798218 0.0500401941380006 0.399082619839385 0.55607368385084 0.182011408780641 0.56456240235188 0.318109648059616 0.558632911051379 0.11178869402018 3.0 0.301915773168882 0.689403464202542 0.326806930333904 0.533436030151442 0.628722703502786 0.298842350012623 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MNS1 0.80668872520192 0.050257413467561 0.399082619839385 0.572518582819317 0.158814436797025 0.543060696740211 0.0237130441744188 1.0 0.718074373820985 0.490052106994285 -1.15371975192568 0.15125932521723 -0.435645378104699 0.698114789587107 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CDH11 1.11596487581795 0.0502625378765388 0.399082619839385 1.21816153363811 0.0317963145593198 0.375031405408838 0.4812656461652771 0.7817773485165469 0.680175170935781 0.29165449645494 4.0 -2.14825168929201 0.053032061413272 0.622328912583358 0.550849540432219 -1.52592277670866 0.113127485709403 partial_or_other True False False True False False False 1 cross_species_direction_conflict +NHSL2 0.80479556446107 0.0503483661324173 0.399082619839385 1.05652686365451 0.0082455786049837 0.287862310479138 0.5308909325899 0.555207867663433 -0.243172460329182 0.717591148724208 0.287718472260717 0.737838635827409 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GPAM -1.22364039953111 0.0513544387300208 0.401629751193748 -1.28868648711867 0.0390101301763025 0.379484931484566 0.379014653672503 1.0 0.494725017885776 0.0723356024214024 -0.0297593128945183 0.914771816997185 0.464965704991258 0.0761648149636735 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RRM2B 0.469687378901058 0.0517017852730272 0.402875896332052 0.199777694046043 0.412266850728244 0.735291083225579 0.636097205020631 0.310442499266324 -0.0722531684585339 0.890844694725049 0.563844036562098 0.326508998919213 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FOXO3 0.82038254769242 0.0517808237376999 0.402875896332052 0.0768446944051162 0.859357868791171 0.956914759994669 0.429650924318511 0.616379079035499 0.311620630168677 0.180518070632458 4.0 -0.531033065091294 0.268640494859393 -0.111083925941443 0.808270511555801 -0.642116991032737 0.147988958903565 partial_or_other True False False True False False False 1 cross_species_direction_conflict +EFHC1 0.433242023523039 0.0519297592565744 0.403142939875671 0.518184609366931 0.0176319657600612 0.326204572615871 0.6931711841046129 0.0548138223783064 2.0 0.191319888203646 0.796041672509641 -1.21467889159985 0.0408427016445781 -1.02335900339621 0.115436149968674 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAP4K5 0.41946563055367 0.0520120118424999 0.403302655195124 0.506366215803985 0.0157656837688812 0.320853404849916 0.135255544071385 0.106782811043955 2.0 0.039596863919605 0.914364815078237 -0.0701150320771714 0.790095963285207 -0.0305181681575664 0.920642268373684 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SAMHD1 1.11434777770014 0.0526809995021064 0.406035451125819 0.236281532360898 0.680359564146708 0.881048329971919 1.25020722327821 1.15649467757574 0.3605700255096579 0.182920667581437 4.0 -0.0812906347950884 0.856473630588214 -0.0597958101026503 0.865903472186746 -0.141086444897739 0.692860349728178 partial_or_other True False False True False False False 1 cross_species_direction_conflict +RBM4 -0.494549024860788 0.0528623912759474 0.406035451125819 -0.595079882414488 0.0172468849164465 0.326204572615871 0.291957084118247 1.0 0.0182652443858694 0.957440974715565 0.411246901284946 0.0810809258185391 0.429512145670815 0.0872462691146195 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DDB2 0.522427597859509 0.053148633566926 0.40614004939973 0.296261680529146 0.286856801165159 0.647144039893536 0.267752161263212 1.0 0.0236228935584197 0.97379932226307 0.197506058484552 0.682011213899072 0.221128952042972 0.692022576561316 partial_or_other True False False False False False True 1 insufficient_or_context_specific +APAF1 0.513919264530311 0.0531621091371876 0.40614004939973 0.499854249089957 0.060786066624804 0.429268745755419 0.507884727522936 0.0697717250249316 -0.712747047396353 0.011607751173525 -0.204862319873417 0.436803758769308 reversed True False False False False False True 1 insufficient_or_context_specific +GAMT -0.671165498301361 0.0541438012380775 0.408770140133979 -0.515233720800576 0.156378835301444 0.539558215777 0.0132520945401364 1.0 0.0641425506487322 0.910703268238692 1.03273778452389 0.0174702259909831 1.09688033517262 0.0192797801662944 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PLTP 0.905728470656572 0.0542803452229192 0.408770140133979 0.475961571437401 0.302893307995385 0.660051093047527 0.530120590456369 1.66196045441292 0.0193708436327205 3.0 -0.233784227142377 0.493562823809985 0.765604390941021 0.0178272488462107 0.531820163798644 0.0825219230043037 partial_or_other True False False False True False False 1 cross_species_direction_conflict +PTPRE 1.12307205668389 0.055370894345513 0.412850293225423 0.9517242439027 0.102474037122828 0.479137456027696 0.429134211529158 1.02147842843917 0.10202562998887 3.0 0.213243270467958 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0.124046632838777 -0.337895135266995 0.0990100278799552 0.0215976175798203 0.932063471589085 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AADAT -0.875150964755736 0.0566593396158431 0.415402171315878 -0.621775446132686 0.192602220984483 0.570885363891703 -1.25608443160988 0.0458694535434945 2.61909107464836 0.0009226106283564 1.36300664303848 0.0178093616330651 reversed False False False False True False False 1 insufficient_or_context_specific +DHX32 0.45187931640611 0.0567146027930577 0.415402171315878 0.386437835279195 0.105793820913222 0.483261130274234 0.0479902983096535 0.0592741623370403 2.0 0.0842812246480819 0.830261829930927 0.100233827187593 0.717591148724208 0.184515051835675 0.543022106905322 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IGFBP7 0.536659927156864 0.0571468878121038 0.416395335762727 0.459380548726036 0.114685971693588 0.492613299848511 0.349535803534566 0.080188533178231 0.116486607754795 3.0 0.792789652237161 0.0634127172436913 -0.485459085911924 0.194346344064947 0.307330566325237 0.430056822052887 reversed True False False False False False True 1 insufficient_or_context_specific +RIPK2 0.567948397174811 0.057763040255816 0.418156600495944 0.260852843120888 0.403526226555316 0.732218158903657 0.468688266525229 0.0231091747477923 2.0 0.0544536891093471 0.917098540731119 -0.208015948094978 0.54638498756475 -0.153562258985631 0.704106811723987 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IFT88 0.337827492277936 0.0577724244133846 0.418156600495944 0.236100278532929 0.190381681083429 0.569920796826702 0.353095045542645 0.413820039889619 -0.34273802718125 0.315641397524554 0.0103570183613948 0.984054493989981 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WASF3 0.591356571964617 0.0577846637737812 0.418156600495944 0.406129141015439 0.193178573488487 0.570885363891703 0.629790711498898 1.11361503154381 0.0788837434405464 0.0562579782380415 4.0 True False False True False False False 1 insufficient_or_context_specific +SUPT7L 0.538570803208318 0.057915056200914 0.41821964730729 0.08070926316539 0.789106576004981 0.926945619655161 0.519445732541665 1.0 0.313614956399122 0.474725275062832 0.101987650596238 0.773698435551437 0.415602606995361 0.275292756158934 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TBC1D23 0.372155930506087 0.0580224420451403 0.41821964730729 0.460157739994235 0.0156564263878143 0.320853404849916 0.348782949611474 0.0948315593087698 0.103079921354279 3.0 0.423592110992463 0.259450872723145 -1.01440158347584 0.0093596695539867 -0.590809472483372 0.106360270774186 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SERF2 0.452132526771665 0.0580633835702626 0.41821964730729 0.678852131933859 0.0028736645547342 0.226419032603616 0.0567080805882031 0.890555344735907 0.0615608837393355 0.848386172268916 0.118268964327539 0.716195109799679 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IL3RA 0.844134715900315 0.0583692490600792 0.41831372574599 0.610496075019878 0.161531143532811 0.543541307772207 0.0222190221403172 1.0 0.257365045044154 0.397563370133043 -0.478913632634204 0.0712674139646295 -0.22154858759005 0.424094383679456 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BRAF 0.275406586289706 0.0586486660171123 0.41883004625994 0.21071675734342 0.155674336888418 0.539558215777 0.379593110949641 0.316481286369564 -0.248269469405623 0.425986649525044 0.131323641544018 0.729021047120079 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MEIS3 0.389539359709644 0.0588621987194988 0.41883004625994 0.26804229122084 0.192861478943999 0.570885363891703 0.325090899065275 1.0 0.778249685359477 0.0945287243828371 -0.815768857280876 0.0500689047561428 -0.0375191719213994 0.941990698118314 reversed True False False False False False True 1 insufficient_or_context_specific +WDR35 0.453979002837585 0.0590220759140185 0.41883004625994 0.294518245338189 0.221682285505843 0.592957341103408 0.55194046057016 1.0 0.39430786877806 0.302883191529254 -0.233654422963991 0.444264910107208 0.160653445814069 0.672215948940881 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PON1 -0.911153309151263 0.0590529041695799 0.41883004625994 -0.869391325137411 0.0733609181325117 0.451366301656794 -0.853613749037709 0.13934463810365 1.98823809738698 0.0038510740420548 1.13462434834927 0.0438338033283869 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RHOQ 0.578465344029069 0.0591095312207888 0.41883004625994 0.570523658045516 0.0632504176885357 0.432999502601999 0.619124936862428 0.145103269513006 2.0 0.863742082783025 0.0188222038975691 -0.80400913049515 0.016600216929097 0.0597329522878752 0.875201419455301 reversed True False False False False False True 1 insufficient_or_context_specific +ABCF1 -0.478030805354792 0.059115610286132 0.41883004625994 -0.576953160366971 0.0176647266500645 0.326204572615871 0.398367161895429 1.0 0.357894135098647 0.224125586597794 0.137822759862555 0.586730192245502 0.495716894961203 0.0776482521106911 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RCHY1 0.400131397713157 0.0596420194381211 0.420026502238599 0.38781656058092 0.0685662646928847 0.438244764077482 0.125337951197119 0.722302943381646 0.199601358326204 0.444111781246765 0.324939309523323 0.251615726365561 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SH3GLB1 0.340369775896132 0.0599485498375375 0.420176101721702 0.293497306005432 0.106734041552272 0.483261130274234 0.621169636917172 1.0 0.254150503621742 0.251926813812424 0.0159423922373237 0.942906902185557 0.270092895859066 0.185400166148387 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ABHD5 0.760124885266812 0.0599496578679362 0.420176101721702 0.657484359493314 0.108020309673425 0.484247542547601 0.0423287223417657 1.0 0.332212830715105 0.420901824876138 0.0400670536335397 0.9165180073619 0.372279884348645 0.309055292678467 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAPK8 0.281996436353069 0.0603649412011677 0.420176101721702 0.177279953179927 0.238984827861793 0.606514283612403 0.113664220029459 0.743465070404838 -0.476245658104099 0.0732394747955915 -0.36258143807464 0.200874162356626 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RAB11A 0.444518577120685 0.0607519000153981 0.421154668655662 0.335303386389037 0.160676557664634 0.543541307772207 0.488126621811552 0.495320734853744 0.0312118870722784 3.0 -0.0079790716664696 0.987274567026432 0.849967771861999 0.0136531712302267 0.84198870019553 0.0238621642159009 partial_or_other True False False False True False False 1 cross_species_direction_conflict +FBXO4 0.708190857371466 0.0609325520204401 0.421206787747816 0.609375134641062 0.109220957370266 0.485176912870447 0.0323962513485063 1.0 0.629404217940438 0.0967869555794027 -0.164044312860132 0.594322031158721 0.465359905080306 0.187592047914215 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ANP32E 0.769347881754093 0.061217765149932 0.4217172266138 0.852135382440343 0.0389863559494725 0.379484931484566 0.250916146830851 0.6779394469021811 0.032166791957964 3.0 0.115480833146023 0.688936764998849 -0.47801581948646 0.0445291697275369 -0.362534986340436 0.134588553467292 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CD2BP2 0.870690946822276 0.0613817317189737 0.4217172266138 0.64282937332209 0.179684638006676 0.562759923872656 0.382988822316128 1.0 0.0916720082184973 0.728713835837385 -0.371697609680749 0.0759412373145068 -0.280025601462252 0.192592617268648 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HDAC9 0.894225688246324 0.0614628459403883 0.4217172266138 0.782838881299315 0.101438932997519 0.478335084675213 1.09906564269412 0.00984749831318608 2.0 1.79541582892811 0.0577091094285948 -1.84085584624953 0.021009926690613 -0.0454400173214201 0.971821319506505 reversed True False False False False False True 1 insufficient_or_context_specific +CTDSP2 0.278624935967185 0.0617643078602549 0.421963941037269 0.264765871265646 0.0750195153777845 0.452862231765951 0.25731999333351 0.349926848373362 -0.107118933867571 0.666645446076101 0.150201059465938 0.561804779391771 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VIPAS39 0.509935476900795 0.0618285349992467 0.421963941037269 0.036902682217463 0.89832049550532 0.967837995533705 0.216629407493468 0.471535345527667 -0.697970839354308 0.0145382876729609 -0.48134143186084 0.0851444600275218 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CASP6 0.474318702381881 0.0619513586599919 0.421963941037269 0.3934445577551 0.12019630478249 0.500999836515407 0.25332676504881 1.0 -0.103526721741604 0.816970922499475 0.788336594699777 0.0212381129231714 0.684809872958172 0.0504747545196111 partial_or_other True False False False True False False 1 cross_species_direction_conflict +FAM98A 0.68631588999572 0.0619843710478974 0.421963941037269 0.296421140157271 0.422740026751562 0.744144334629103 0.0741395732043674 0.804826425997151 -0.0714300961316587 0.754197934452526 0.0027094770727087 0.992760846097494 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IPO9 0.341938309166408 0.0620347567250481 0.421963941037269 0.25298942031371 0.165841287217134 0.545468009482397 0.529601756327938 1.0 0.584469772671828 0.0295214121411202 -0.532909621834426 0.0283761772708502 0.0515601508374018 0.851187176049742 reversed True False False False False False True 1 insufficient_or_context_specific +KLF10 -1.12848501890794 0.0620394448722595 0.421963941037269 -1.169168483354 0.0535322023166129 0.417274996791505 0.151077600974327 1.0 0.443278626940135 0.490052106994285 0.710489740311691 0.145991392673332 1.15376836725183 0.0473736748509004 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ADH5 0.476311579769399 0.062067626485213 0.421963941037269 0.07931615070722 0.755288952695258 0.914278922558648 0.0476936668804192 1.0 -0.383476377348598 0.406343807178581 1.30512737339467 0.0071611528081619 0.921650996046074 0.0375893407233316 partial_or_other True False False False True False False 1 cross_species_direction_conflict +ADAMTS1 0.941162177624175 0.0624115418108231 0.423438218283982 0.0024429613148776 0.996375847635566 0.998795540446485 0.329580513876623 0.595696637918574 0.295702789280727 3.0 0.419296747525312 0.240059418609136 0.0216353387903697 0.952179584858255 0.440932086315681 0.180721495283218 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RORA 0.423471071418586 0.062557459720207 0.423458235676911 0.219808553435008 0.349492696825621 0.694288655897113 0.915751721205275 0.27259774678572 0.2754081338765539 3.0 0.230813762881621 0.520316567244718 0.127119940221015 0.674608220210568 0.357933703102636 0.247306415582077 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CDK19 0.381046277815559 0.062595632404312 0.423458235676911 0.22554700038833 0.281732736586879 0.64315368591277 0.0825380014368234 0.10693830990105 2.0 0.471543167296024 0.159351274500249 -0.815027070253142 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+TRPS1 0.465454733614304 0.0803997142453162 0.454575327117713 0.609065840022363 0.0202018675849206 0.332725011651872 2.0280439248761 0.12494668502458 0.132322533104253 3.0 0.678526516830652 0.0879662689103056 -0.0844095234971389 0.808298615552142 0.594116993333513 0.111553482731439 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SYTL4 0.636311016382571 0.0813456914638529 0.45678312590043 0.283337967147764 0.432102310231709 0.750968920399405 0.132418342497495 0.104025122409657 2.0 0.045572501738383 0.949213952797514 -1.58787951737567 0.0102391053289871 -1.54230701563729 0.0217800779198426 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CPSF6 0.284686157577887 0.0814231713340225 0.45678312590043 0.172743580959986 0.304787680800838 0.661341495477036 0.152114728063992 0.635755731378264 -0.256020444690275 0.314178977613949 -0.103905716626283 0.72182057674908 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PECR -0.806327586130806 0.0817272805663568 0.457428892751606 -0.759585117228736 0.102772531991008 0.479239170340314 -0.535466975607783 0.154054156460104 1.18220867438352 0.0049476344620666 0.646741698775735 0.0688723554229974 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GSTK1 -0.412766411866522 0.0821013865280767 0.458153508965874 -0.305158557376338 0.203937901841927 0.577025563405608 -0.393025896455553 0.209096358103193 1.48798858146874 0.0007754435398958 1.09496268501318 0.004051719474331 partial_or_other False False False False True False False 1 insufficient_or_context_specific +OXNAD1 0.37485887850301 0.0823864681267942 0.458585841408647 0.308327730182099 0.156146984398795 0.539558215777 0.302187204851243 1.0 0.107139294612584 0.843696053451533 0.39634420680292 0.258578864972825 0.503483501415505 0.201594233875257 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TPGS2 0.427357250158062 0.0824677090979821 0.458585841408647 0.30957128430679 0.208807440694861 0.581072472023285 0.337412585959792 0.591406277572281 0.261155732991415 0.551058983973569 0.598568318951207 0.249077815077982 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ARMC2 0.456590115425687 0.0828303845014482 0.458585841408647 0.356896959584886 0.174071362674417 0.555912113465366 0.499284950272477 0.363225756768359 0.0468600713936428 3.0 1.35851095937929 0.0908365637289931 -0.584276768461129 0.301230657556912 0.77423419091816 0.321464507860803 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCZ1 0.368095921861597 0.083345376699528 0.459276129369083 0.321213761612807 0.131655552451034 0.517896578143491 0.0416977364614901 0.905790421240866 -0.272870745982655 0.247660021314654 -0.231173009521165 0.364011360670613 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TBC1D12 0.300671339359732 0.0834191843328376 0.459372030894287 0.361049894469522 0.0374939624526954 0.379484931484566 0.0492394348187929 1.0 0.590061188723345 0.0789497824640368 -0.0802355698647261 0.780646178036658 0.509825618858618 0.10628174684105 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ID3 0.506828319142724 0.0835763089799235 0.459372030894287 0.124124518064739 0.667716559811864 0.875419277100913 0.661135788871405 0.3519996870816571 2.0 0.730318817659981 0.0274929723905575 -0.50059768714893 0.0826729601006068 0.229721130511051 0.435066613838366 reversed True False False False False False True 1 insufficient_or_context_specific +EPHB2 0.895498817887935 0.0841192662940964 0.460216624403445 1.04626761273544 0.044645097147233 0.393650849907072 0.0862498152944245 1.0 1.21085364257487 0.0286094852492482 -0.647987372870944 0.125519267975672 0.562866269703929 0.266237544146871 reversed True False False False False False True 1 insufficient_or_context_specific +TCTN1 0.459658957072697 0.0841492520478257 0.460216624403445 0.368490457983702 0.175963291087948 0.557953042949168 0.333557053939343 0.386040422240987 -0.511273978767264 0.110729239947426 -0.17771692482792 0.6351603677909 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ADCY1 0.57030424951326 0.0845185296014807 0.460216624403445 0.664962014062906 0.0447193674597732 0.393650849907072 0.606586567925125 1.0 1.94340079178969 0.0853233494305288 -2.57906049153543 0.0146965476533192 -0.635659699745736 0.681447514131604 reversed True False False False False False True 1 insufficient_or_context_specific +DICER1 0.25373800204448 0.0846935931441594 0.460216624403445 0.366795909717201 0.0103468260459788 0.302245517751671 0.7993019827143991 0.905346091307452 2.0 0.209031720284001 0.432313793181377 -0.41042234383389 0.0747618378929744 -0.20139062354989 0.398940133569479 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC38A6 0.426603152545684 0.085295972965092 0.461588190705957 0.497702444156287 0.0449322384101481 0.393650849907072 0.482253085957828 0.0882719772118809 -1.05535449204866 0.0024478115353263 -0.573101406090831 0.0437197422979425 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPATS2 0.280367199674467 0.0853466144157457 0.461623747439264 0.321710447670297 0.046656407054003 0.398865057227663 0.7716584476310829 0.0750665493469392 2.0 0.646364990314486 0.0446573805664781 -0.511071024783294 0.0619696300205183 0.135293965531192 0.669347140489099 reversed True False False False False False True 1 insufficient_or_context_specific +ECH1 0.72753010949279 0.085846703426941 0.463379087311679 0.927737462843698 0.0302879777208386 0.374450197630696 0.345151602936853 0.0288444428556145 2.0 -0.0038463540335898 0.993768636619091 0.861513192769274 0.0160437455061367 0.857666838735684 0.0217061917331625 partial_or_other True False False False True False False 1 cross_species_direction_conflict +ANTXR1 0.407971540023675 0.0864252579643402 0.46414282853471 0.459386985854448 0.0496922659607074 0.40534943521819 0.384497053898587 0.222191376773737 0.117668966301437 3.0 0.79681811001124 0.0165843725805584 -0.820991574297698 0.0105416193511565 -0.0241734642864578 0.942660682843177 reversed True False False False False False True 1 insufficient_or_context_specific +ODF2L 0.320745172040864 0.0865935864852173 0.464748710712694 0.48329448234508 0.0073948966412254 0.287862310479138 0.0605920957467287 1.0 0.308465439297824 0.369649684210199 -0.75525933630732 0.0197863226739372 -0.446793897009496 0.166734937348249 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CD40 0.562577618878392 0.0867492002213855 0.465158992350121 0.640668138358153 0.0500410827662557 0.40534943521819 0.44204401843077 1.0 0.965227886112026 0.108510320725145 -1.09566713075317 0.0394152404890652 -0.130439244641143 0.846494600271507 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MTRF1 0.392718521560913 0.0872396761615598 0.466131832446229 0.275622873485195 0.220199153116333 0.59217704709374 0.638061142167654 1.0 0.0259471935737502 0.965819679450514 0.296817487828102 0.421593429730507 0.322764681401852 0.452967912514766 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TANGO2 -0.493327225576224 0.0874792937310098 0.46650493983352 -0.529869811702521 0.0634943297011892 0.432999502601999 0.361351598710201 0.304402496389925 2.0 0.263804622358223 0.509565091024756 0.352826615505437 0.262612049677984 0.61663123786366 0.0829255268040131 partial_or_other False False False False True False False 1 insufficient_or_context_specific +HAMP -1.06293078768355 0.0876548071450382 0.466932115962318 -1.09988101590857 0.0764114104222275 0.455668688469891 -0.121927177201022 0.874976692694041 1.22793544816037 0.0368939149261647 1.10600827095935 0.0635280993925464 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NUP37 0.545278763412221 0.0883910546845702 0.46849033903599 0.643016243282267 0.0439943485767399 0.393650849907072 0.729199004695095 0.13590337854805 -0.90406959384973 0.0386936443094331 -0.174870589154635 0.735905920269629 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PDE7A 0.382795560936272 0.0887116550276941 0.468777604495693 0.257850288835708 0.257939888093818 0.621906676979798 0.174489809959349 0.675913744273884 -0.423244138659352 0.177070162808091 -0.248754328700004 0.484997022470032 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IQCB1 0.343411359794498 0.0890143628491023 0.469671985487667 0.411458376761963 0.0407088365088317 0.385820373303632 0.0598826914578555 1.0 0.353410722461969 0.48851729371843 -0.382934206581931 0.32808382982545 -0.0295234841199623 0.95598497872577 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CYB5R3 -0.381124392096788 0.0893529260340978 0.470048925295468 -0.489483150512705 0.0227777305196166 0.346028040476539 0.3702984012039791 1.0 -0.102992253705263 0.852146947349664 0.811737906312329 0.0498677127822032 0.708745652607066 0.0898530637373285 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PHF3 0.38940451614805 0.0896698265758378 0.470775766926124 0.3406420828169 0.140029628561172 0.525466309117542 0.00119034348505787 0.11883618079159 2.0 0.330151285538918 0.226334573177427 -0.203431168313917 0.380773860917228 0.126720117225001 0.636823625502751 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TOP2B 0.312847224286099 0.0901286305386331 0.472180378842888 0.410779290703876 0.0225814712397968 0.346028040476539 0.541267156026659 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0.833021985935722 0.123704131466909 2.0 0.255395026297145 0.395934579615013 -0.427977567252417 0.101370082051278 -0.172582540955272 0.537286248397879 partial_or_other True False False False False False True 1 insufficient_or_context_specific +YTHDC2 0.243053941784028 0.0917371752134338 0.47312329130067 0.229466867003556 0.113382356765011 0.4924007041452 0.325652633947166 0.473988617995776 -0.219196622631475 0.53592383719198 0.106456011315691 0.814615285484709 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IKZF1 1.04683863067514 0.0919278481208737 0.47312329130067 0.354211144701738 0.544711807404759 0.815113627216777 1.46952918798433 0.127252575967881 -0.946789393528217 0.180409000769591 0.522739794456117 0.608119365637099 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RDH16 -0.887217057178438 0.0920306605003958 0.47312329130067 -0.496935754636582 0.356074124776228 0.699495346273692 -0.412953550887754 0.471119257261521 1.40166359291314 0.0095543932840246 0.988710042025383 0.0514999557441282 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TPCN1 0.304501579691484 0.09266195318215 0.475145654053977 0.170114514262617 0.355220854620296 0.698568957090478 0.387757029649955 1.29617841218701 0.132876325214886 0.112726104702669 4.0 -0.286995705685684 0.361768021054596 0.132173666755785 0.635307229551734 -0.154822038929899 0.600799600845759 partial_or_other True False False True False False False 1 cross_species_direction_conflict +RP2 0.606778144984693 0.0933067122579866 0.476139327220794 0.495929142564905 0.176937307313191 0.559145193239352 0.142685306054436 0.699778136427172 -0.316053733527729 0.25037257366667 -0.173368427473293 0.589535480158036 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NHS 0.641307846113642 0.0936366037580025 0.476750142624258 0.745270128155278 0.0492411224711361 0.404267318079514 0.639804115058043 0.210016327037956 0.161617262037465 3.0 0.933765511071011 0.365223213466271 -0.842147442780575 0.260253278149629 0.0916180682904364 0.939798992054325 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BET1 0.619237070268427 0.0940324904949187 0.477507276304264 0.744027638150159 0.0430803208477935 0.391483132487066 0.0431799352945782 1.0 0.0136839386055611 0.967610304956895 0.350135740034395 0.127535800812897 0.363819678639957 0.136021128729103 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PAPOLG 0.324222549833376 0.0940910932406619 0.477507276304264 0.360221141031437 0.0623654359556249 0.431813959784778 0.0281689474452482 0.954530635502806 0.122882263048706 0.706417010676886 0.151051210493954 0.685035523624829 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC12A2 0.53967296947567 0.0945548874211757 0.477889182093238 0.691910479532395 0.0302287953349248 0.374450197630696 0.3398669647089411 1.0 0.446035434224786 0.333752535287331 -0.548387866725181 0.145991392673332 -0.102352432500394 0.835549729418328 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UBAC1 0.344030227174482 0.0951277424827232 0.479258078302265 0.202874358164165 0.336328043856193 0.684718759551425 0.643660616122615 0.18816189864139 -0.0970921707933277 0.808913661743001 0.546568445329287 0.229137443039796 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TEX2 0.530047093768827 0.0951576908580996 0.479258078302265 0.770757956224416 0.015277417890311 0.320673912695634 0.843234596698494 1.99316419178162 0.185246758133786 0.16263028345322 4.0 -0.633040562548943 0.052930380201887 0.382968799007219 0.177228112638595 -0.250071763541724 0.397314858868387 reversed True False False True False False False 1 cross_species_direction_conflict +PISD -0.394806128640369 0.0962705441610474 0.480151093364473 -0.389297075147277 0.101413042898011 0.478335084675213 0.531128043190364 0.191869477491155 0.179949028871753 0.603087584877972 0.711077072062117 0.0683769392665597 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NIPA2 -0.275132593253837 0.0965057213929684 0.480151093364473 -0.18565295020619 0.273460077805315 0.6371317291179 0.46099522148124 0.257764781801764 0.415230852374192 0.196254904474676 0.876226073855432 0.030135639991491 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ALG13 0.214334437543335 0.0973298969197659 0.480902509202512 0.241674113947609 0.0593866721962004 0.428473540531152 0.844884331800326 0.270784566618285 -0.206426470834516 0.72694246705075 0.63845786096581 0.374200674264365 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LRRC57 0.469052742737588 0.0973420524276092 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0.0982896930551157 0.481998411182495 0.0701392830954779 0.744182711620328 0.909384383019378 0.379182828031496 0.131203833225347 -0.591301291618022 0.0180023058783866 -0.212118463586526 0.364896454881563 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FAM126A 0.295420997524574 0.0994983891883238 0.484549812292584 0.296834058564416 0.0972910235626161 0.478125555523304 0.0918932651054573 1.0 0.67324203935482 0.154928620956831 -1.54231786628638 0.0042143350509754 -0.869075826931565 0.0889827093778124 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BCAS3 0.249055212835776 0.0999865453035019 0.486389058212075 0.221017009832198 0.147720173674786 0.532846198833773 0.336932306742799 0.112882863756028 0.114070131124679 3.0 0.0492892854271943 0.925767992223804 0.435237100119474 0.199801682785657 0.484526385546668 0.191218753368653 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DSTN 0.474507536858501 0.100308102168976 0.486389058212075 0.228651203540582 0.458834137579799 0.768201799558117 0.0917756094718016 1.0 -0.119746335313325 0.763974060480545 1.07739704962738 0.0043578022554296 0.957650714314054 0.0109886815635963 partial_or_other True False False False True False False 1 cross_species_direction_conflict +TMCC3 -0.731878687367736 0.100559079798202 0.486389058212075 -0.844019748481021 0.0556011435278546 0.421331649096072 0.296209583620988 1.0 0.443925594637034 0.125802729052737 0.167915180524715 0.487229895375958 0.611840775161749 0.0345981392012996 partial_or_other False False False False True False False 1 insufficient_or_context_specific +AIDA 0.374133222135505 0.100621163196638 0.486389058212075 0.50523844224306 0.0254564225009932 0.351006805738558 0.0392231803541145 1.0 0.323395104640797 0.560983902319736 -0.144587196969643 0.746678464448261 0.178807907671154 0.731590118676138 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HMGXB4 0.299935195889398 0.100991055924271 0.48727013909526 0.121738097457334 0.50535305700854 0.792858629327505 0.7450680394296509 1.0 0.39438792050826 0.191433240261074 0.0340251384604694 0.904879342928437 0.42841305896873 0.127696076463546 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TULP3 0.271545939061821 0.101428142083983 0.488073489121063 0.191571746916972 0.236823330222292 0.605329180588419 0.573134527669884 0.0487694103605387 -0.163916436352022 0.490365846585061 0.409218091317862 0.124977920570671 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAML1 -0.244364130726391 0.101841237104795 0.488194981201462 -0.329278504988305 0.0222916560382091 0.346028040476539 0.27783537069766 1.0 0.296992533967198 0.275012296484195 0.272897120208684 0.223972102244969 0.569889654175881 0.0342508406509268 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DPP7 -0.645309751862511 0.102185557388767 0.488311932876063 -0.488862718368339 0.231115432332738 0.601518427890281 0.286189647962958 0.357458084101065 0.224574892772117 0.373272720782481 0.510764540735076 0.077123916475219 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TOB2 -0.655453065761295 0.102278343111324 0.488311932876063 -0.916639076068542 0.0158200292347521 0.320853404849916 0.5783162606645671 0.256851622618015 2.0 0.241558337993796 0.496580273555236 0.510383526930355 0.0767702823716384 0.751941864924151 0.0271568768747579 partial_or_other False False False False True False False 1 insufficient_or_context_specific +FOXJ2 0.424509892737717 0.102678979697405 0.488987220408302 0.292163999787168 0.244944410659979 0.610669341516615 0.148207327959474 0.772593231311149 -0.0427329470729446 0.919228163577521 0.10547438088653 0.816536064181449 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WTAP 0.316011672832893 0.102786338101236 0.489277798770444 0.17426367563924 0.390918846155091 0.722443755943541 0.0405163192334541 0.0531589291675161 2.0 0.0498511294938927 0.885896209712577 -0.0498023499485677 0.849564180264112 4.87795453250058e-05 0.99993056693209 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAIP1 0.420406227059501 0.103179016467018 0.489675432165043 0.142617809199379 0.593401229696089 0.839379713709982 0.0177476260598177 0.971220331487005 0.262870733031502 0.408606206471751 0.28061835909132 0.434728409603005 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GPANK1 0.534488496248064 0.10339147457454 0.489949366498203 0.434257321419886 0.182432277819048 0.564667601143233 0.276765257736606 1.0 0.0433208230179697 0.924777329702809 -0.0417849740154832 0.90368326870113 0.0015358490024865 0.997105815330813 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SNRPA1 0.324040600190359 0.103897666379179 0.490464203492951 0.357358213487126 0.0713434780941496 0.445706770247356 0.0309407331981791 1.0 0.322430355179716 0.283680773601636 -0.436003714171477 0.0946449360296362 -0.113573358991761 0.705831888568513 partial_or_other True False False False False False True 1 insufficient_or_context_specific +L3MBTL2 -0.493888119129744 0.104053553915192 0.490464203492951 -0.569871091920111 0.0553298747114776 0.421331649096072 0.536224136071871 0.134662167627002 0.14287810562432 0.63121069395239 0.679102241696191 0.0509793879816853 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ARID2 0.258546925155945 0.10415944335905 0.490464203492951 0.311505436597193 0.0462815553362619 0.398741839274603 0.0851743898619908 1.0 0.383059333265301 0.128871924761007 -0.460613447519307 0.0474427273380442 -0.0775541142540055 0.765697159206029 partial_or_other True False False False False False True 1 insufficient_or_context_specific +XPNPEP1 0.36602595761427 0.104581605988149 0.491288094314487 0.36345794348705 0.107242461630447 0.483286684531078 0.430096254372757 0.03956850425146601 2.0 0.095460764312937 0.763833046449035 -0.284621432587323 0.225442413043454 -0.189160668274386 0.457839861594272 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HSD17B7 -0.720498757995529 0.105302321856944 0.491938900073281 -0.916149169189757 0.0334564209623051 0.376280667109215 0.011967540302328 1.0 0.206509580589826 0.701284020990754 0.917569773670534 0.023070613258961 1.12407935426036 0.019698098475891 partial_or_other False False False False True False False 1 insufficient_or_context_specific +UBR5 0.270755266094201 0.105557165604252 0.492472901849632 0.355908130602286 0.0297989292410277 0.371448754340933 1.33024718273356 1.0 0.0376958548882811 0.893114015241429 -0.264091078402528 0.173893584899424 -0.226395223514246 0.266167318010001 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EIF3M 0.461216442305642 0.105603206079519 0.492472901849632 0.286372321198502 0.306221373364419 0.661696690217148 0.0405784599661255 1.0 0.211635445079237 0.639010697485095 0.163985617368705 0.626382705106563 0.375621062447942 0.312567192566721 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SORCS2 0.745949474005319 0.105707310324965 0.492740742786306 0.486671435869438 0.292969802842963 0.651509781962399 1.0160829241793 0.745908270536225 0.0892386880157165 3.0 1.26349733358779 0.060725149951687 -0.57813896412311 0.231582749240545 0.685358369464679 0.28732002992825 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PDCL 0.567721749205496 0.105905577827372 0.493229418042079 0.472965900484869 0.168466132077352 0.547956075931201 0.0059892361450646 0.98971837936101 0.454334401909807 0.123828264840496 0.460323638054871 0.149711433519521 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KRR1 0.370055140507275 0.106643811959806 0.494520186619343 0.296605431449823 0.200261651957191 0.575556382365159 0.14304249390013 0.679022909639013 -0.137562626303511 0.605258176863272 0.0054798675966199 0.987346287125091 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAP2K5 0.331514152421977 0.107181718298463 0.495457347546047 0.380077871982589 0.0614377604518671 0.430431237459066 0.12574941769243 0.807772272153713 -0.455347764482156 0.205789311661792 -0.329598346789726 0.417390734044782 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BTG3 0.634025550110222 0.10745132412936 0.495746611144434 0.0413654610918044 0.913244326532043 0.97354943452396 0.271069474225079 0.673733895854192 0.506492689102152 0.243828926572549 0.777562163327231 0.130175783253176 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KCNE4 1.05167486980616 0.108130727248168 0.497015332296979 0.897316956946805 0.171722362043214 0.552641842639707 0.6771520285045519 0.381104710406786 0.0753653348467218 3.0 0.436844729128594 0.597929527179738 -0.275937013486285 0.651861647147555 0.160907715642308 0.843188603495081 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SMYD4 0.362375146424233 0.110466460631406 0.50036681364622 0.145236994716486 0.50308496349012 0.79229878349175 0.9753399241323 1.0 0.562649071527722 0.290074575005487 -0.646314055320711 0.135941388237593 -0.0836649837929897 0.887723156365506 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPP1CB 0.775209740089243 0.110925536334103 0.501563945445592 0.0213298686951241 0.963865580365099 0.989935386867005 0.242789061803236 0.0494444262271708 2.0 0.0669527952007075 0.828688869279738 -0.178480897947367 0.41778501640315 -0.111528102746659 0.651967957005312 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ETFA 0.34333404227444 0.111065189176493 0.501587325415229 0.229398980451141 0.300779247388783 0.658632920234719 0.528192638702195 0.3973765905648839 2.0 -0.165615432087809 0.766314190681721 1.02093278279413 0.0271243717739403 0.855317350706319 0.062290902625138 partial_or_other True False False False True False False 1 cross_species_direction_conflict +PLCE1 0.602697830333371 0.111078358477654 0.501587325415229 0.701043613745616 0.062321683388077 0.431813959784778 0.584809434557249 0.0446965446227696 2.0 0.487688382900751 0.193549260486952 -0.516919104568548 0.116788712572487 -0.029230721667797 0.942660682843177 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NDUFS1 -0.233036478183748 0.111229026972185 0.501737698716141 -0.035889113576549 0.814594440901167 0.935641141872961 0.0039957370644637 0.991871972474593 0.516281024305679 0.0388189523586232 0.520276761370143 0.0478518963621695 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TNFSF13B 0.395158218455746 0.111296617767873 0.501737698716141 0.488351500109871 0.0441944808796004 0.393650849907072 1.23465847317078 1.0 0.152144514257345 0.741228382096128 0.343177961570369 0.278090752200502 0.495322475827713 0.17159084121827 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MSRB3 0.425563188583547 0.111717582052962 0.502776739691036 0.285603305095428 0.304150133546762 0.661341495477036 0.3648223502028111 0.0796823847018647 0.0980434722373533 3.0 0.399363791185452 0.174836620623234 -0.454375862904184 0.0810656541066896 -0.0550120717187315 0.861515585833504 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ALKBH1 0.414651705562213 0.111872713975585 0.503046045210487 0.363782598505239 0.162391368463052 0.544121887728627 0.64986243130524 1.0 0.0982012193353737 0.781566229686838 -0.970018335740514 0.0048022230535926 -0.871817116405141 0.0116262027364317 partial_or_other True False False False False False True 1 insufficient_or_context_specific +S100A6 0.924073310378143 0.112400107158569 0.503657147489441 1.24761665403988 0.032727361398881 0.375031405408838 0.29585671331389 1.0 0.130769641229416 0.8890677464436 0.248142918938762 0.702269861046463 0.378912560168178 0.593204410119545 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PIGB 0.400706088309258 0.112648768956069 0.503960043490755 0.391547082350763 0.121788674808984 0.503485437181972 0.548883391791663 0.193010785431213 -0.0973071532897175 0.786936818217172 0.451576238501946 0.248405364806512 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LANCL1 0.300140939390171 0.113194597655612 0.50499717252955 0.235810759187556 0.215612465253419 0.587852789707652 0.0545551118362967 0.862121950436023 0.201528293642545 0.350298248598067 0.256083405478841 0.266604302486844 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CACUL1 0.298622061350191 0.113892492629184 0.505495336947715 0.389632907563663 0.038779706299766 0.379484931484566 0.575239978073055 0.291195909727862 0.223567007043296 0.622277403215581 0.798806985116351 0.11150728424137 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DMTF1 0.252140359927415 0.114235045600911 0.506018923663156 0.257272646228738 0.105954038550989 0.483261130274234 0.0807888166883788 0.0673392145651569 2.0 0.154790237832264 0.587662004240426 -0.301862939914865 0.184425537386271 -0.147072702082601 0.561804779391771 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EXOC4 0.319827411986866 0.114470537258523 0.506529728573128 0.392012909384413 0.047425008237627 0.401231297569097 0.0584450845227882 1.0 0.420285313079607 0.136469840319014 -0.237068670956146 0.336372124647226 0.183216642123461 0.49028981584618 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MTMR1 0.253178571081656 0.115201649866275 0.507484271612428 0.199006937590072 0.216615131416491 0.588377298043559 0.110737203723676 0.843136433162649 0.418496187457671 0.248717386077604 0.529233391181347 0.193864470914924 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZNHIT6 0.349646132460644 0.11529095745792 0.507588519560785 0.254356113317495 0.258420739353659 0.622239083830955 0.0827712663292504 1.0 0.0443060823457546 0.929619161467188 -0.539995443642209 0.104346657221878 -0.495689361296454 0.17070205011387 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZC3H6 0.430364454697424 0.115399824851475 0.507588519560785 0.199711830138005 0.479908577222545 0.780162456875056 0.123493727152765 0.812066470422655 -0.398277023977219 0.272602780298722 -0.274783296824454 0.50413283499357 partial_or_other True False False False False False True 1 insufficient_or_context_specific +L3MBTL3 0.512890269752151 0.115924582301966 0.508107354047744 0.686809282151804 0.0337643320235386 0.376543096535729 0.049278196046294 1.0 0.21458979784191 0.635086683540577 -0.384113731741367 0.260003460991761 -0.169523933899457 0.683169836203475 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CEPT1 0.323723337286932 0.115973913316624 0.508107354047744 0.216013658541007 0.293172273045249 0.651509781962399 0.151524013900321 0.664875881263502 0.0845016843374498 0.772918035140286 0.236025698237771 0.414439818851846 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PYGO1 0.467020726929752 0.115982072670493 0.508107354047744 0.770352930544169 0.0095193492647122 0.298763048903795 0.0454564899022074 1.0 2.20007209520326 0.0169051077070871 -0.900462907428126 0.105967960575702 1.29960918777514 0.145626776194681 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SDR39U1 -0.589649570117964 0.116249048226658 0.508433078366633 -0.698188928934013 0.0587675784606521 0.427941109491281 0.0440428991477737 1.0 0.0833440994418153 0.915993062050496 0.876280722887797 0.0630926785380164 0.959624822329612 0.0772497817650887 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DHX35 0.348912995586419 0.116556279656023 0.508475415992879 0.408010879375245 0.0655977273560754 0.435533238803682 0.714275036342359 2.1522917922586 0.0518477465074492 3.0 0.244338292020228 0.535743432094959 -0.92263198796448 0.0134538631575704 -0.678293695944251 0.0683769392665597 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMA16 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+KIFAP3 0.356461404861758 0.117518142505196 0.509172485612679 0.494062533193291 0.0312461264590688 0.375031405408838 0.0483908214276334 1.0 0.312057487927968 0.479435275639114 -0.356160796089866 0.309788950024164 -0.0441033081618984 0.923755646681849 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FUBP1 0.259150412796829 0.117546929048033 0.509172485612679 0.41776098201821 0.0048281109776986 0.261521011602645 0.0920576888628436 1.0 0.482591975541942 0.0876181862376438 -0.760899681358962 0.0102391053289871 -0.278307705817019 0.286079594039358 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FAM185A 0.398111626832799 0.117599663445506 0.509172485612679 0.547501960361384 0.0255277794019015 0.351006805738558 0.0817815671687035 1.0 0.373982142284937 0.389864280618717 -0.486537818776027 0.166222664916675 -0.11255567649109 0.802043756527463 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GALNT10 0.462787023634038 0.118640392010497 0.510107670287165 0.412627092192645 0.165798682293315 0.545468009482397 0.107123300787005 0.0711042233929608 2.0 0.194219803507417 0.534159113399912 0.0207587351181098 0.942395283913998 0.214978538625527 0.426372639705684 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NEMP1 0.494796683120621 0.11866115156519 0.510107670287165 0.258265429455475 0.42520191603504 0.746032896912571 0.538715360992271 0.439961253243198 -1.59454243656976 0.018173674864407 -1.05582707557749 0.156885480353538 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ASCC3 0.335521120939031 0.119364856995532 0.510957753488216 0.454656408793121 0.0279835129474621 0.364752999628771 0.0831091163629687 0.770025916959417 -0.188058609544988 0.373272720782481 -0.104949493182019 0.66147298310895 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FRS2 0.231881930079321 0.119535359375896 0.510957753488216 0.228351409402266 0.124763055634911 0.507064043928032 0.0821828937628186 0.0855554339924105 2.0 0.238307143355194 0.396346661020818 -0.260076026230559 0.268559874640953 -0.0217688828753643 0.941142242357347 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CEP83 0.477321330951125 0.119613344168863 0.511079598435798 0.488102145828302 0.111734406157925 0.490094278471416 0.718108111697719 0.214368782749322 0.0959515444832396 3.0 0.358234202574161 0.346855565090479 -0.824568663622939 0.0224545452524276 -0.466334461048778 0.192592617268648 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VPS36 0.220309818870339 0.119905797484005 0.511707926368683 0.199707271795119 0.157453764034023 0.540968708321254 0.543069523431855 0.0742128078934692 -0.163822325864443 0.525524511599149 0.379247197567413 0.177903306218242 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LTBP4 0.423866150478744 0.120681236093862 0.513401146844548 0.559713069135542 0.0384363660676661 0.379484931484566 0.597588700042917 0.433988171169433 0.130157229229954 0.108339266911802 4.0 -0.0044129357647505 0.992862411288349 0.0825824509637372 0.814662296315053 0.0781695151989867 0.838218981960542 partial_or_other True False False True False False False 1 cross_species_direction_conflict +SCAMP5 0.490760753099024 0.120701126224161 0.513401146844548 0.441207769887747 0.164243825546109 0.544850245278 0.123089526768261 0.759455697445548 -0.315163165805755 0.277636714907892 -0.192073639037494 0.567113450214708 partial_or_other True False False False False False True 1 insufficient_or_context_specific +STAM2 0.255998904459976 0.120874057319286 0.513401146844548 0.234557564262677 0.156594297805473 0.539558215777 0.201333627441778 0.660455575960264 0.0775670291538217 0.832315411798087 0.278900656595599 0.463658924878681 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TRAP1 -0.355877130602971 0.121031961971593 0.513401146844548 -0.376962503130979 0.0986869339102096 0.478125555523304 -0.0768751855760337 0.817126893380336 0.559306649536262 0.0310425740309211 0.482431463960228 0.0657105312071235 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TPK1 0.380671383859852 0.121980981179267 0.514532640547624 0.343985696242339 0.164147334564989 0.544850245278 0.188879061578922 0.622969514344774 -0.381328586923655 0.197256153982353 -0.192449525344733 0.573209548736223 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZMIZ1 -0.30879306852927 0.123204697191223 0.517202219794854 -0.366627437922019 0.0598159897786139 0.428473540531152 0.658235652947556 1.0 -0.351424252050177 0.138514244222139 0.907646479857341 0.0019115534652006 0.556222227807164 0.0225896267849194 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ITGB1BP1 0.449528303454637 0.123433095540213 0.517202219794854 0.543706996771174 0.0599354164252721 0.428473540531152 1.03774246427255 0.05305275319073901 2.0 0.169957480365417 0.570393547157362 -0.442664974509203 0.0719579217081249 -0.272707494143786 0.291374675713076 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ANGEL2 0.326061553932798 0.123541201261818 0.517202219794854 0.0140998000397196 0.947453118438759 0.986094250821001 0.325342270557903 0.537255715012207 -0.528497866594021 0.199420108680584 -0.203155596036117 0.687812477277199 partial_or_other True False False False False False True 1 insufficient_or_context_specific +XRCC4 0.415531854133985 0.123797087280928 0.517432491191746 0.378851109766397 0.163176464781927 0.544298760692042 0.0265754780393653 1.0 0.0981266536589317 0.77419391088713 -0.342395119959308 0.169587713356049 -0.244268466300376 0.37135754729829 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GOLT1B 0.550235760646951 0.124210490996295 0.518286724559294 0.603639004991688 0.0925447834587916 0.472460751419842 0.0337047739712995 1.0 0.734816618482982 0.0592354571252899 -0.186960184316076 0.561246175716411 0.547856434166906 0.12783012579458 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SH3YL1 0.329354541861751 0.124572333990268 0.518625671241816 0.556988425247384 0.0078828408759411 0.287862310479138 0.064426660817622 0.929619161467188 -0.444141728558167 0.336356692999722 -0.379715067740545 0.479481663529604 partial_or_other True False False False False False True 1 insufficient_or_context_specific +THBS3 0.48572678603839 0.124843860624671 0.519255417647061 0.159539438707241 0.620296788809281 0.854153589708151 0.350219711631161 0.611052213838264 -1.28969887709745 0.0336240795032459 -0.939479165466286 0.13867954443462 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPP2R2A 0.249625284120574 0.124940357823765 0.519292711671211 0.258929178551513 0.10903167544651 0.485176912870447 0.280114520527502 0.427842744261142 0.194914133647524 0.480180558395696 0.475028654175026 0.129869556975458 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAP1B 0.612118028489114 0.125118463879321 0.519465490223309 0.616653689262634 0.122558247336552 0.5038394341269 1.3104584853222 1.44998894960082 0.3839000311859571 0.294122383953892 4.0 -0.286903156924696 0.858126111808387 0.0876359693734546 0.94058725478829 -0.199267187551241 0.883664590772004 partial_or_other True False False True False False False 1 cross_species_direction_conflict +BMPR2 -0.39550520853468 0.125908361629944 0.520697407790421 -0.240449566294047 0.351922749023691 0.696141927344537 0.188100063118843 0.313654027692028 2.0 -0.0940687640937595 0.713363633773811 0.617776399283699 0.0085493405367599 0.523707635189939 0.0240155681819601 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RAB23 0.386391569785189 0.126259482737933 0.521332662787286 0.169174254933301 0.52059832240729 0.801118945922776 0.257590758722618 0.473988617995776 -0.715748494160664 0.0265330988034598 -0.458157735438046 0.163583259771627 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SCPEP1 0.438353819815677 0.126309212257587 0.521334113766851 0.233469209442947 0.409811990897668 0.735004110999004 0.359637671768872 1.0 0.501444833195446 0.255060661942655 0.0146697714140647 0.973317763671041 0.516114604609511 0.201713707725247 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SHROOM4 0.363267561462348 0.127386169792957 0.522820192778903 0.514365521951051 0.031061047332913 0.375031405408838 0.589804915911819 0.272834071870126 0.0269658326060303 0.953167269763767 0.616770748517849 0.210267113310644 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CALM1 0.289940847949998 0.128483959647268 0.525177563281399 0.206379990686496 0.276912001116458 0.640025592773108 0.7938958420409341 1.0 -0.0969415748750501 0.790249002791818 0.906767425207836 0.0060349363502649 0.809825850332786 0.0149200055406564 partial_or_other True False False False True False False 1 cross_species_direction_conflict +PREPL 0.39869016067539 0.128858326571474 0.525893394643071 0.480359712189467 0.0645764627416167 0.434266429061139 0.0488806743830317 1.0 0.197294737925953 0.589758153478615 -0.0261575987315299 0.935412028627536 0.171137139194423 0.596743098604647 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HDAC8 0.209575590578992 0.129553119839533 0.527302173965225 0.212400926589945 0.122364805284937 0.5038394341269 0.123646125651296 0.686655566435864 -0.165931333200292 0.481904030747853 -0.042285207548996 0.885881059091602 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ARID1B 0.296662429460054 0.129973745303192 0.528140364327409 0.39766101422149 0.0392187424347947 0.379484931484566 0.349488264857136 0.281827471656966 0.0512727291353112 0.0778034078164953 4.0 -0.034799486586443 0.932202662560267 0.390546901802297 0.14828625321815 0.355747415215853 0.211661774784192 partial_or_other True False False True False False False 1 cross_species_direction_conflict +CLPTM1 -0.289931764017499 0.13028373030006 0.528140364327409 -0.232542418229894 0.223230018110189 0.594234827022923 0.9061799972243969 0.339485884071451 2.0 0.0852892574728029 0.813377867232966 0.433242285062449 0.100330207933636 0.518531542535252 0.0689563322752153 partial_or_other False False False False True False False 1 insufficient_or_context_specific +THBD 1.0374870229604 0.131667690103701 0.531062284493215 0.242348465616331 0.692852268866692 0.886799724697293 0.718912453867131 0.0140827211824098 -0.4816722180744 0.0505205340297246 0.237240235792731 0.347378977593184 reversed True False False False False False True 1 insufficient_or_context_specific +UTP25 0.542979954323929 0.132204801958676 0.531719623772676 0.578422560676041 0.109256249326986 0.485176912870447 0.0314186933574637 1.0 0.0190045635134636 0.963652041662651 -0.339550322457068 0.224088352976701 -0.320545758943604 0.295785518509798 partial_or_other True False False False False False True 1 insufficient_or_context_specific +STARD5 -0.52112143157186 0.13225002197642 0.531719623772676 -0.310523502753397 0.378811659273008 0.716066842028319 0.0220336283459338 1.0 -0.471542150991344 0.102373850277688 0.936644962548989 0.0039566153281876 0.465102811557645 0.0833189204387499 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SAV1 0.440614711496814 0.132820954011728 0.53320290207446 0.261381849745452 0.376929733866959 0.714218257388254 0.269794100074087 0.31073900714346 -0.17382891409052 0.446027251136159 0.0959651859835678 0.715123135841064 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SUCO 0.336377481557382 0.132894521533554 0.533295461174939 0.470739850410902 0.0338357907780641 0.376543096535729 0.319978391935243 0.254843762675387 -0.266365621586916 0.25504325212582 0.053612770348327 0.857233256423977 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MARK3 0.244746707503459 0.133318249176764 0.534183709604657 0.12019681709009 0.466603533402301 0.771437536119871 0.433657624474091 0.547303702861186 2.0 0.214728699457464 0.466612457465412 -0.354496820541411 0.151935364644522 -0.139768121083947 0.60768857677038 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WDR61 0.386392879250507 0.134458626163668 0.535616764110931 0.214286189667583 0.419941453534819 0.741990190194073 0.391518329099634 1.0 0.155728660907939 0.602416154640461 0.264561387884209 0.242987058286369 0.420290048792149 0.100350370546065 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ARL2BP 0.548663070003269 0.134691258157319 0.535616764110931 0.436991882646326 0.236915232084244 0.605329180588419 0.298276336587792 1.0 0.424850583092339 0.239274963409279 -0.583105833806583 0.0633316933519861 -0.158255250714244 0.667334866367796 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SYDE1 -0.467703019311878 0.134799677906167 0.535616764110931 -0.34078752242206 0.291481150553695 0.650899755355335 0.552632266308974 1.0 0.224628989359031 0.529113251543877 0.358346904292232 0.199683185116545 0.582975893651263 0.0669083391296753 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RB1CC1 0.317448009499242 0.134977866382505 0.535616764110931 0.271604152102804 0.204246045011353 0.577301933200215 0.384714976409781 0.102900758095728 2.0 0.233732970683418 0.445583082983027 0.0750291686844531 0.78063187276686 0.308762139367871 0.252151421124247 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WRAP73 0.537246593972073 0.135360104763 0.535616764110931 0.41422460835896 0.252829811284886 0.618991529980024 0.238412738754941 0.559520649104807 -0.0783056667555358 0.814218572445008 0.160107071999405 0.669256457541427 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPP4R3B 0.23646553352845 0.135403231133376 0.535616764110931 0.307228976262302 0.0466207744626077 0.398865057227663 0.0513926351653216 0.0846547438422323 2.0 0.298284227451214 0.26845219967212 -0.15896100663146 0.490222053010812 0.139323220819754 0.590034275997834 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CWC27 0.313406377002444 0.135622785901462 0.535616764110931 0.328170306759769 0.117987112149013 0.497635840420285 0.5653179055476409 1.0 0.148980621060834 0.709516190581248 -0.181068993850717 0.548849005712963 -0.032088372789883 0.933602644063331 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PTPRM 0.32331904762862 0.135646082332894 0.535616764110931 0.47391915667094 0.0262839494062086 0.354273049744177 0.9040110452973 0.0962789348999438 2.0 0.85546711650293 0.0097846096425437 -0.38434852280126 0.125695443097513 0.471118593701669 0.100846261338861 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SETD5 0.226545699114546 0.13678726310556 0.537198696892096 0.193756156399028 0.206548198743796 0.579524500741323 0.607068376496183 1.0 0.0983567397215056 0.735736231267021 -0.279771744710684 0.208817388820099 -0.181415004989178 0.443463796575476 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GALK2 0.299112205302929 0.136818270121505 0.537198696892096 0.392951370986801 0.0480882979388765 0.402009816708327 0.409962093034284 0.107220363176986 -0.416976720407732 0.0645864155228596 -0.0070146273734478 0.981346740807273 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CRTC3 0.350027814936484 0.13688562351233 0.537263350573675 0.253006202130485 0.293888390068157 0.652324662738756 1.4718611918526 0.462004633761141 0.139380630589802 3.0 -0.0012471891506287 0.99699280592687 0.447142878742531 0.0605094278135818 0.445895689591902 0.0796635312003842 partial_or_other True False False False True False False 1 cross_species_direction_conflict +TSEN15 0.274841151114294 0.136964615744257 0.537352351696503 0.279733196646936 0.12938391458242 0.51412697409153 0.8117592011181909 1.0 0.330776050095108 0.535376406350753 0.036411044319756 0.937036079890938 0.367187094414864 0.425570285641061 partial_or_other True False False False False False True 1 insufficient_or_context_specific +POMP 0.376291296221436 0.137266588617295 0.537488043399431 0.458514982433171 0.0655518555231638 0.435533238803682 0.028381034328296 1.0 -0.552743154955023 0.0633191330872892 1.02649911576745 0.0030507204347802 0.473755960812429 0.0835563993808325 reversed True False False False True False False 1 cross_species_direction_conflict +SFPQ 0.178656206223517 0.137422941454314 0.537488043399431 0.0908283028005031 0.451560768078948 0.764202910889105 0.554412209376411 0.436250733312876 2.0 0.322704533164025 0.233658535785586 -0.254625309030064 0.280515289001006 0.0680792241339613 0.807263673090137 partial_or_other True False False False False False True 1 insufficient_or_context_specific +INPP5F 0.405011056666017 0.137879510953739 0.537488043399431 0.563792164156322 0.0381395898122213 0.379484931484566 0.165692638262823 1.0 0.147033377996369 0.771518108449609 0.442681404680616 0.198431053226562 0.589714782676984 0.133017174144526 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PTBP2 0.262346160975587 0.137965110863202 0.537488043399431 0.269678099935595 0.125861999511328 0.507996233320616 0.699540366468283 0.35223726085192 2.0 0.227377142237503 0.488220617755228 -0.659954016409776 0.0277895275422278 -0.432576874172273 0.138303939022004 partial_or_other True False False False False False True 1 insufficient_or_context_specific +THSD7A -0.656444925533252 0.13806285032196 0.537488043399431 -1.06331943840451 0.0131384650584538 0.313114831651016 0.842143914599513 0.216414362388195 0.410669971183064 0.407205620653328 1.25281388578258 0.0527904389355648 partial_or_other False False False False True False False 1 insufficient_or_context_specific +YPEL5 0.395409941085208 0.138496263100351 0.53781086837707 0.495541959212125 0.0628508817296641 0.432999502601999 0.0316437194918344 1.0 0.0450309209938219 0.915993062050496 0.378862723481942 0.174140748094176 0.423893644475764 0.158360781712976 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ANKRD40 0.373966793497461 0.138839189001953 0.538524672109706 0.162987589695407 0.518356384727083 0.800840369846825 0.315615530812234 0.400748814048635 2.0 0.15766587708325 0.682441736116258 0.0666467109128673 0.840088269286153 0.224312587996118 0.484519380563252 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PRKAB2 0.394458082317544 0.139287575538853 0.538692149078545 0.112329479249955 0.669039225793069 0.876002815388656 0.0231284578669463 1.0 0.548320930767811 0.0870273744456065 -1.05071713240028 0.0042175563951795 -0.502396201632469 0.101339519241949 reversed True False False False False False True 1 insufficient_or_context_specific +MGA 0.224501148600223 0.139391648996568 0.538692149078545 0.291449813193075 0.0500639954086494 0.40534943521819 0.6307920356527379 0.939256544298147 0.0941283910513629 3.0 0.0390397441864825 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0.0490037064866443 partial_or_other False False False False True False False 1 insufficient_or_context_specific +THOC1 0.239101887182819 0.140662677324971 0.538942462388233 0.0590609571113077 0.729655692778674 0.904204533048315 0.137381496091868 0.653980268706307 -0.334900827106894 0.15848025066263 -0.197519331015026 0.444651541138023 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DZIP3 0.340911540714721 0.140730936094941 0.538942462388233 0.348422922603952 0.13204489065806 0.518314929773221 0.0509931537047592 1.0 0.636408452259279 0.18355542375304 -0.454362570904103 0.238178461086442 0.182045881355176 0.71085094565801 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACVR1 -0.261527098243594 0.141032081121133 0.539284658628661 -0.0509177189586691 0.779963915783862 0.923604645900181 1.2035043526335 1.0 0.20244647971554 0.420901824876138 0.251544384844707 0.220997882653384 0.453990864560247 0.0530204589818224 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RARRES2 -0.485497353197478 0.141566810136201 0.53998172024417 -0.427732555275683 0.195566667865612 0.571527055075728 -0.558078765529389 0.173863667871272 1.35878892659057 0.0043671799920026 0.80071016106118 0.0468930610740237 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ARNTL2 0.674214459863625 0.142403496365486 0.541020552222669 0.871859354643238 0.0608807278237727 0.429268745755419 0.982003268787332 0.11452678129389 -1.62231660740348 0.0101899517752211 -0.640313338616144 0.329992453274922 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMOD1 0.506678304108278 0.14266060560457 0.541526244832017 0.205258801399967 0.548319850860849 0.816156774016399 0.393097206942986 0.8508346722576129 0.177754278032351 0.173887143538994 4.0 True False False True False False False 1 insufficient_or_context_specific +BSG 0.408975785856374 0.142875111347362 0.541649000882252 0.226640832499701 0.40965704064188 0.734946310126928 0.595418033534727 0.665024932729522 2.0 -0.0480456462079939 0.930095922530229 0.959039880568565 0.0190078314334657 0.910994234360571 0.0301135439163634 partial_or_other True False False False True False False 1 cross_species_direction_conflict +GHITM 0.52332483236807 0.14308866616865 0.541788979679847 0.274305971227105 0.433318140775234 0.751350456611089 1.95439618036352 1.0 -0.139174648400968 0.756771455527206 1.22976342708863 0.0043411408218517 1.09058877868767 0.0107550361347177 partial_or_other True False False False True False False 1 cross_species_direction_conflict +ARMC9 0.459875446034851 0.143118911188397 0.541788979679847 0.587487144720126 0.0555737863586243 0.421331649096072 0.6431288218247599 0.949282118261725 0.123513513089648 0.115247031042531 4.0 -0.497120347632713 0.182560032256214 -0.382122393523391 0.245824670346556 -0.879242741156104 0.0257908623027394 partial_or_other True False False True False False False 1 cross_species_direction_conflict +ATP10A 0.506455472663676 0.143644951118706 0.54262288458519 0.368327668782681 0.294640816467359 0.652324662738756 0.377771733561246 0.133353526046074 2.0 0.216897763497352 0.803482466161172 -1.0783150987617 0.0939503276003386 -0.86141733526435 0.251130851858594 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PRIMPOL 0.378329214290305 0.143878876935297 0.542863498953353 0.536938038073508 0.0327152165750799 0.375031405408838 0.0198074643829182 1.0 0.126248388164951 0.856911477299003 -0.647386848627268 0.175486243552968 -0.521138460462317 0.335698859720097 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BROX 0.408655108821474 0.144332296398398 0.543861162633013 0.197531713373725 0.476209703423795 0.777939354595146 0.0766692720392704 0.843911857110284 0.267643669593472 0.299240838946481 0.344312941632743 0.226910244066112 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ARMC10 0.350177590749348 0.144865684312631 0.544536151420452 0.425500831910375 0.0752719502276224 0.453382804479479 0.0274318170097624 1.0 0.0933439855602098 0.898124348847813 0.180297932906819 0.700279370815945 0.273641918467029 0.61424725694592 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HLTF 0.462428356922482 0.145003767503028 0.544536151420452 0.547375730481325 0.0838708870328607 0.464779732481256 0.306591130180776 0.367294583103341 -1.02472768508769 0.0053898032229831 -0.718136554906911 0.0396757426500509 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AGBL5 0.506817397730631 0.145094678527315 0.544536151420452 0.464761473808765 0.185817481289729 0.56775396895769 0.437913761623784 0.357320930173022 2.0 0.104782866727396 0.867994151464597 -0.407241222520269 0.328931021286695 -0.302458355792873 0.539719576913921 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KATNBL1 0.224699489433819 0.145651143977752 0.545156956185198 0.246111940577498 0.108572127572011 0.485105595812652 0.194703475006406 0.634465385582764 -0.195160302490718 0.529244508712609 -0.0004568274843124 0.999330727138224 partial_or_other True False False False False False True 1 insufficient_or_context_specific +L3HYPDH 0.410598726855356 0.145734518897196 0.545156956185198 0.440114573353139 0.118531837775794 0.498589300094356 0.04279646485743199 1.0 0.418209373629359 0.0972774047969517 -0.393385673251733 0.0788300473776612 0.0248237003776259 0.927986539692061 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EXOC5 0.214117068732366 0.145798884187947 0.545156956185198 0.269553116988621 0.0664173630740601 0.436362488696905 0.290058515840518 0.225535190100696 -0.404578007780054 0.0618995016647975 -0.114519491939536 0.626423506237674 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TENT2 0.237059371602339 0.146216272108397 0.546028060173363 0.335641346195766 0.0325087238718452 0.375031405408838 0.0783769086450622 0.836546151633562 0.172609256061108 0.506163023948819 0.25098616470617 0.37305938205724 partial_or_other True False False False False False True 1 insufficient_or_context_specific +STXBP5 0.319794637409941 0.146290145056645 0.546028060173363 0.388440798325522 0.0742363323182649 0.452862231765951 0.543412764838572 0.188107042079834 -0.0385880913617987 0.92300736979681 0.504824673476773 0.187358814716169 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ENTPD1 0.727716727218287 0.146590623323409 0.546092267228673 0.71832186770774 0.153068165572503 0.536485533522497 0.8984533792982901 0.0756692395416046 2.0 0.761943047241944 0.320349903765884 0.267691026283252 0.630357985642576 1.0296340735252 0.133908589850972 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VCAM1 1.15442950360246 0.14674379283077 0.546092267228673 1.1870741842139 0.136300873412149 0.523136620282319 0.0797962817046873 1.0 0.0428516121734752 0.949950680556985 0.132326173966424 0.786442255146625 0.175177786139899 0.739323634347189 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM245 0.269974968308445 0.146814128967495 0.546092267228673 0.0969790093922767 0.609007264944626 0.848013066172034 0.252700093615555 1.0 0.29923542052529 0.216304153579614 -0.359191293090334 0.0946184192410373 -0.0599558725650447 0.81192776574905 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TTLL5 0.26857124263899 0.147439488364547 0.546407533152709 0.105478208671789 0.581408873005238 0.83332444054994 0.337245199134711 1.0 0.102945128650823 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0.949528132681026 0.250063543560737 0.501915483923286 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WWOX 0.242742366465284 0.148821358639032 0.547689432491821 0.264392086183341 0.111123140406932 0.488819418659101 0.115609447188589 0.679020910630793 0.221089771853814 0.269320731853826 4.0 -0.397032918053915 0.31445781310552 -0.502291062080463 0.149430225134797 -0.899323980134377 0.0272463803640322 partial_or_other True False False True False False False 1 cross_species_direction_conflict +KIF7 0.434425247746482 0.150359407817271 0.549496236668308 0.387367855029453 0.202516891761579 0.57668584531318 0.486771990142688 0.188635466154894 -0.544962196383732 0.0854363604073321 -0.0581902062410437 0.88754738061924 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CUEDC2 -0.520096103633479 0.150803655218023 0.550357757273381 -0.398454959697745 0.279562733830771 0.642114507827558 0.783547633697323 1.0 0.310288906272092 0.311968659832509 0.19760548340345 0.434170859625625 0.507894389675543 0.0775337926389589 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PRR3 0.333497820607645 0.151155599038434 0.550531585105462 0.41626442991582 0.0676583252843266 0.43786261079484 0.412216521973508 0.315346628424899 2.0 0.16525556095803 0.774462607140807 -0.832404598962936 0.0608277706203789 -0.667149038004906 0.168477094648534 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KSR1 0.624867728789079 0.151550161113355 0.550809250413692 0.737046773476334 0.0921053588435515 0.472460751419842 0.549688026617159 1.19964589499422 0.339148015465764 0.216159906327038 4.0 -0.0503872184462002 0.917945009132389 -0.179755381196725 0.589485875096484 -0.230142599642925 0.520691916165381 partial_or_other True False False True False False False 1 cross_species_direction_conflict +TSN 0.456762424463154 0.151649315193205 0.550809250413692 0.146746677353195 0.650847626432408 0.869901306439436 0.231445124760339 0.522224134414054 0.185688243200765 0.527726797503334 0.417133367961103 0.181678224446525 partial_or_other True False False False False False True 1 insufficient_or_context_specific +COL1A2 0.57330229624641 0.151793289021061 0.550809250413692 0.911721013424425 0.0173348991812161 0.326204572615871 0.325215915306695 0.283896895319057 2.0 2.55948680050161 0.0018357596416774 -2.55736231948079 0.00210154604062 0.0021244810208269 0.997836888554868 reversed True False False False False False True 1 insufficient_or_context_specific +NCKAP1 0.286626663380311 0.152040035084559 0.550809250413692 0.451277663975332 0.017863241377667 0.32629129734252 0.0348680683089535 0.919633172864329 -0.0340052738233993 0.900217493371686 0.0008627944855541 0.997836888554868 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MBD4 0.304243213705017 0.152143560073412 0.550809250413692 0.219148780458175 0.310310155094842 0.663746883608458 0.951773134130273 0.158003090385823 -0.619306773179537 0.225442413043454 0.332466360950735 0.633798386476644 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UBAP1 0.260971783403474 0.152425128873132 0.550809250413692 0.0536811511830184 0.780115101703781 0.923680076683697 0.0696173984585514 1.0 0.0490325602514597 0.901577906130256 0.325009751888544 0.206267168923709 0.374042312140003 0.184818641807572 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GPATCH8 0.227392081014464 0.152695772656166 0.550809250413692 0.105844060343958 0.506455032753091 0.793608039538775 0.0695693971840902 0.838111718819019 0.0240696241725014 0.93030670335507 0.0936390213565916 0.734365035274665 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PTCH2 0.673674922575876 0.152846135061336 0.550955784901873 1.12348044241998 0.0163374676801578 0.325244142514861 0.053748595482875 1.0 0.177682453371383 0.865711176141888 -0.565587804696127 0.41331151607678 -0.387905351324744 0.656191165930492 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GMFB 0.469654263056787 0.153085400970859 0.551229450649633 0.426564123889154 0.19971714377947 0.575263953748573 0.433053092199567 0.174201984262681 -0.305182058024577 0.268337489966817 0.127871034174991 0.687406299245416 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NAE1 0.293329361318375 0.153675458757449 0.552167465823386 0.199377462099115 0.322251342546878 0.672877524535327 0.0822654362063913 0.827717425323655 -0.58263306614531 0.0429621316207372 -0.500367629938919 0.0898530637373285 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ANKRD16 0.427562607708606 0.153748860186256 0.552167465823386 0.436585015506019 0.145295712337937 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0.0662613274878893 0.436071024157137 0.456432774705288 0.127286744636273 0.07225514618998799 3.0 0.720328008572914 0.303412244260649 -0.0517557986284919 0.930852252028654 0.668572209944422 0.2958434547675 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC25A21 -0.378478664361607 0.155059909284871 0.554449863769332 -0.454429266120868 0.0881464357811962 0.468622105620855 -0.579032246711343 0.333330502553279 1.63194671705103 0.0039432448540661 1.05291447033968 0.037480318894471 partial_or_other False False False False True False False 1 insufficient_or_context_specific +HBP1 0.532838969665881 0.155338991448065 0.555097569014293 0.206787788762832 0.582451799171072 0.833494998054781 0.0111419180083616 0.4726334886282221 0.0631476654138602 0.0894477451420484 4.0 -0.131451384042554 0.654366038993584 0.429086041957528 0.0711610875267414 0.297634657914974 0.21822676580414 partial_or_other True False False True False False False 1 cross_species_direction_conflict +ELP5 0.534711683909229 0.155743040628801 0.555097569014293 0.136687593444927 0.706051287287904 0.892947759038953 0.4365305896759361 1.0 0.213322831262588 0.45526006351472 -0.100693866872907 0.679611196462262 0.112628964389681 0.677825268215581 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PGM3 0.261868133771074 0.157094138703063 0.557330824147538 0.278193284559254 0.13051311791081 0.515895731524648 0.0740869464485122 0.857218206831363 -0.445064634542818 0.122308345007819 -0.370977688094306 0.228599568100294 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SMNDC1 -0.32382981439821 0.157147782065502 0.557330824147538 -0.246928546824356 0.288670503059433 0.648310091921223 1.13031587673152 0.179396303140375 0.700617542920563 0.208629316418549 1.83093341965208 0.0262451999009054 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SETD7 0.322802275715956 0.157600987978523 0.55818180340625 0.366305960214179 0.107488981306481 0.48374623385926 0.0650064708015954 1.0 0.06889617198017 0.846388159848326 -0.261584075597799 0.286278502933351 -0.192687903617629 0.474295673545989 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SIKE1 0.528033142088795 0.158946774110516 0.560190281865661 0.439848192415759 0.241805936082257 0.608725035015447 0.0186070801916007 1.0 0.270105917456472 0.298120008161861 -0.467283572414492 0.0491833777559882 -0.197177654958019 0.410058643237479 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FUCA2 0.547431945006653 0.159190373386906 0.560617732561358 0.779286679795056 0.047931291972978 0.401952804329389 0.4150878462518909 0.0192984735835727 2.0 0.787501930892563 0.18778214022247 -1.13451210737433 0.0320352186128655 -0.347010176481765 0.592940298567946 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DONSON 0.409804214234936 0.161842627053397 0.563502444760982 0.365531483178638 0.213110964306264 0.585944156548318 0.0346120576941291 1.0 0.548596270828964 0.137197113942135 -1.23260110079812 0.0038510740420548 -0.684004829969161 0.0719165601208997 partial_or_other True False False False False False True 1 insufficient_or_context_specific +USP3 0.223528529431974 0.162037641816096 0.563502444760982 0.234999532467762 0.140269620784554 0.525724762599689 0.0826713582026943 1.0 0.265032634746963 0.415605940026351 -0.0248287656243787 0.936995361088253 0.240203869122584 0.409509530854742 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAST4 0.33648982091642 0.162306304811347 0.563879554523921 0.114194467748267 0.655614236087056 0.871565739688635 0.958360557611147 1.0 0.379689219152993 0.212769512048425 0.0820188614976572 0.763276683201078 0.46170808065065 0.106277848470273 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACSF2 -0.596928744453349 0.162368277437374 0.563909300389405 -0.600555549051773 0.159766078438761 0.543504910610905 -0.0952795991823459 0.769529305936767 0.673914162166755 0.014781317215436 0.578634562984409 0.0355694835727315 partial_or_other False False False False True False False 1 insufficient_or_context_specific +AP5M1 0.282948302511796 0.164558099045228 0.566137811285775 0.265432313729727 0.193695512547467 0.570885363891703 0.700425800997634 0.0217360296660551 -0.336473551486327 0.159982503792165 0.363952249511307 0.180724472259337 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TTC17 0.18130509752772 0.164589534559338 0.566137811285775 0.159821982309517 0.2209071362134 0.5925760086083 0.105078195903439 0.683680235761055 -0.472383161092062 0.0303985813323003 -0.367304965188623 0.0932422102479162 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DNAJB1 1.20957221082031 0.164696240908304 0.566137811285775 1.25760381984343 0.150590029855393 0.533583468169136 0.637854295507145 1.0 0.215385417113316 0.690301867608146 -0.102119751498273 0.818885387327953 0.113265665615043 0.820795203351876 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MTMR6 0.353758305867619 0.164779455775827 0.566137811285775 0.219818581203483 0.385369774062954 0.719875101655461 0.178459005518311 0.541096566273747 0.0366848101600066 0.891281641518237 0.215143815678318 0.392366273210751 partial_or_other True False False False False False True 1 insufficient_or_context_specific +YEATS2 0.362223020781236 0.165052436132469 0.566508265962038 0.547925963128902 0.032589162557177 0.375031405408838 0.103988457499037 0.0630005749939038 2.0 0.0864530271175935 0.864077958896805 -0.82015563460389 0.0335484455130118 -0.733702607486296 0.0688307560056457 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TBK1 0.308190832736929 0.165229341148311 0.566660148634735 0.327316636291894 0.13861704121468 0.523810858054217 0.226049925752097 0.389498649467937 -0.233522019939366 0.285169850142996 -0.0074720941872685 0.980088887108866 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RAB11FIP2 0.32240557344074 0.165464917501404 0.566972925771516 0.361054039941189 0.117458033007008 0.497239639401058 0.315269472126154 0.26283991607122 -0.441855948170377 0.0740400397204819 -0.126586476044224 0.649204140188311 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ARHGEF25 0.453051389454534 0.166416888063946 0.567989912537313 0.243705700755256 0.447739973865629 0.76196625468622 0.362884458289947 0.386966283877942 -1.14382516367119 0.0088844953388967 -0.780940705381244 0.0541462784712616 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AEBP2 0.288474407787098 0.166769034490054 0.568349730841184 0.357928965404646 0.0770015288737204 0.455668688469891 0.07002275118977 1.0 0.15006568404414 0.64876414120596 -0.88128354832605 0.0065981466046256 -0.73121786428191 0.0217800779198426 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EML4 0.330554959602485 0.166823447158188 0.568351711873556 0.536354714082609 0.0175168660509 0.326204572615871 0.9043270627490481 0.135839934110082 2.0 0.501430906172721 0.0664858469404258 -0.744479560085004 0.0090440260036451 -0.243048653912282 0.334674444347233 reversed True False False False False False True 1 insufficient_or_context_specific +GAB2 0.377940327828664 0.167081249820486 0.568715760001446 0.778990923461559 0.0025859074425383 0.224500148429329 1.36666160008874 0.198410869683043 0.19793562262418 3.0 0.224579846200954 0.559547408243361 -0.23733488466698 0.441674253571125 -0.0127550384660258 0.974700350418372 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TRIO 0.235825844921555 0.167090172897703 0.568715760001446 0.275439072516625 0.101526429344977 0.478533946885832 0.633702928530651 0.120368834319486 0.0814773764848123 3.0 0.0353001247882985 0.924286122028271 -0.716432544354859 0.0142287523645604 -0.681132419566561 0.0235691553749684 partial_or_other True False False False False False True 1 insufficient_or_context_specific +COL4A2 0.588279429382406 0.167193247978058 0.568715760001446 0.244021969126046 0.575972647884099 0.829928048970172 0.374862412417494 0.40872399011741 0.289841378698326 3.0 1.59692106855225 0.0012190377515281 -1.37251407370332 0.0029994447458525 0.224406994848928 0.533335368241833 reversed True False False False False False True 1 insufficient_or_context_specific +SLC25A27 0.357471199334769 0.167258522055237 0.568715760001446 0.228988289163973 0.377929431044316 0.715214004833462 0.0644734903397055 1.0 0.453558058790871 0.17862564462609 -0.699226728405886 0.0282926639150248 -0.245668669615015 0.445565700497412 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATF7IP 0.277895432312801 0.167307364137573 0.568715760001446 0.186820861950191 0.358134600361767 0.701648749419101 0.394061926214712 0.205814568733279 -0.303149962010411 0.259089644634366 0.0909119642043009 0.77698947081037 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SMURF2 0.254396777372162 0.168312489299823 0.570163793948294 0.309730949901736 0.0902500707423449 0.471946630459474 0.9893746912190609 1.0 0.166908928581605 0.48851729371843 -0.180847172337393 0.357931966993697 -0.013938243755788 0.954950787833519 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UNC50 0.386406478459397 0.168749976538959 0.570679773317849 0.678756706478651 0.0101170002067249 0.302245517751671 0.190092775388623 0.504229880857343 0.0198575909761551 0.940311244788927 0.209950366364778 0.397314858868387 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LIX1L 0.334669548229712 0.168926932820946 0.570765977431346 0.300996015566326 0.215489682011279 0.587852789707652 0.29378992683637 0.236526664187806 -0.25988748138589 0.22615595912348 0.0339024454504803 0.89931880437347 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BCL2L11 0.410029332973362 0.168937647231763 0.570765977431346 0.171269755815058 0.551536176509149 0.817853785334775 0.5400687646819949 1.0 0.359773615753032 0.278578283820612 -0.357149475640485 0.202360829813575 0.002624140112547 0.995116920374074 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FABP1 -0.712472648700324 0.169109172504531 0.570832862139676 0.0751008480870054 0.881726737362943 0.962618478946739 -0.724399131956345 0.327369814686324 2.27558423728262 0.0063950802174883 1.55118510532628 0.0360013361442554 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CEP152 0.31997645937887 0.169346272331019 0.571337398444576 0.297918830338767 0.205160591042977 0.578666837313374 0.7260102845792329 1.0 0.445252214400106 0.23546237458658 -0.709616217556122 0.0370347733755747 -0.264364003156015 0.469546742012676 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ADAMTS12 0.372950283214435 0.17006276964078 0.571856753217971 0.263203687526584 0.335218715396999 0.684461073909613 0.524518211303575 0.533059927399931 2.0 1.92096115569252 0.0001979531072831 -1.62314065729237 0.0008604455294357 0.297820498400159 0.361485140150103 reversed True False False False False False True 1 insufficient_or_context_specific +ATXN10 0.27893024289378 0.170309379367612 0.571856753217971 0.460263197473808 0.0170086925774762 0.326204572615871 0.116572892013482 0.0903360931845016 2.0 0.10263621537885 0.730448388495279 0.0888007733660377 0.706684431594126 0.191436988744888 0.426789832852421 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DACT1 0.602858859750232 0.170333232533925 0.571856753217971 0.797073310556363 0.0703769543808994 0.443089546602487 0.0372825415883336 1.0 0.0034616150431612 0.994258934601955 0.12129147552291 0.697357707802488 0.124753090566071 0.713216351079149 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TRMT1L 0.309837621169598 0.170636094882815 0.571856753217971 0.100045822249185 0.670413720500263 0.876638417082195 0.157416991967595 0.56724880758769 -0.362424695171773 0.103806564648478 -0.205007703204178 0.388810272428763 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EXOSC9 0.428519721386609 0.170661031501873 0.571856753217971 0.610416591471145 0.0627918525373592 0.432999502601999 0.0245970223073173 1.0 0.650661675332402 0.026076493442787 -0.500500090908286 0.0445291697275369 0.150161584424116 0.584361990067919 reversed True False False False False False True 1 insufficient_or_context_specific +GRK4 0.377772273124169 0.170996415509496 0.571856753217971 0.492986959191655 0.0704989000378795 0.443089546602487 0.0609230839996033 1.0 0.757787694226096 0.161863485694136 -1.2437634020934 0.0170295936873771 -0.485975707867309 0.382163494801586 partial_or_other True False False False False False True 1 insufficient_or_context_specific +OTUD7B 0.191942214971308 0.171209521609842 0.571856753217971 0.0892693608957963 0.535081742068591 0.810930391494977 0.141930872574484 0.28729424926804 2.0 0.263889556193101 0.289366410868311 -0.165107685737019 0.438040386745301 0.0987818704560823 0.687400428138426 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MED6 0.396832341277585 0.172372856956412 0.572299567215659 0.486406387741009 0.0936030187194863 0.473775578029617 0.0753915009378053 0.855224142933824 -0.1769183071139 0.527726797503334 -0.101526806176094 0.764871493844153 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MALAT1 0.317695914509565 0.17283172839985 0.573051190684154 0.527928960578103 0.0172956667324838 0.326204572615871 0.366658968581747 0.3609561454419939 0.0220144451900648 0.0680615221826413 4.0 True False False True False False False 1 insufficient_or_context_specific +SNX3 0.328271852901449 0.172884137989121 0.573051190684154 0.305761815049576 0.204703303095594 0.578030883681005 0.0390935748416953 1.0 0.0534684041454984 0.872319475012779 0.139243660137449 0.555631507400705 0.192712064282948 0.434024575676335 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UNC45A 0.28185585672623 0.17395783241384 0.573676192501689 0.0641768260099917 0.771706522967319 0.920641521976153 0.308536205644122 0.219678741923982 -0.396317610039124 0.0764625916626596 -0.0877814043950027 0.731550572972114 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PLXNC1 0.507694581075138 0.17422170581531 0.573676192501689 0.538519235427934 0.150774671701114 0.53368255534016 0.46274908877245 0.56913818535247 2.0 0.0134777881428943 0.976242672823949 0.0373829272461904 0.914771816997185 0.0508607153890848 0.893105727313485 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ELP3 0.293425037537925 0.174577685707217 0.573943487468955 0.393302982075112 0.0684787471987709 0.438244764077482 0.4417433220504939 1.0 0.133803958981831 0.657673469002243 -0.262770873690488 0.260003460991761 -0.128966914708657 0.626082439253009 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZCCHC4 0.385396258382221 0.175473344234085 0.574820840342372 0.205674269764552 0.450003439755458 0.763939182518913 0.264482977395425 0.635711947218112 -0.459046670445486 0.277636714907892 -0.194563693050061 0.707254917340578 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GLUL 0.765432194282921 0.177911327033397 0.579391668975509 0.367327011988936 0.520306333793944 0.801118945922776 0.0419760259998809 0.245636441874117 0.125235952650099 3.0 -2.35496273248446 0.0003947081041676 3.20777544020493 0.000157183914281 0.852812707720471 0.0473736748509004 reversed True False False False True False False 1 cross_species_direction_conflict +SINHCAF 0.4762279272602 0.178917567136827 0.580473135729219 0.542501054488036 0.124434357516371 0.506540133615104 0.0529622561332137 1.0 0.196129750037468 0.83289069999139 -0.338667042324875 0.582990000893757 -0.142537292287407 0.862960964824455 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AEBP1 0.489263141893849 0.179489109371283 0.580473135729219 0.410048436968288 0.259012217735177 0.622885940784012 0.585934519161693 0.333887188066351 0.189834319498749 3.0 0.763877394391954 0.181626715567711 -0.154808960660488 0.767419953720059 0.609068433731466 0.248405364806512 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TEX10 0.329783856815845 0.179892212827367 0.580473135729219 0.10878316826084 0.671892334164688 0.877088599168621 0.337469547592928 0.366260730701264 -0.755116892733822 0.0291646235742549 -0.417647345140894 0.228620711329176 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UBE2E1 0.341356065869192 0.180414053346627 0.580747619213834 0.367023949013346 0.147495749635453 0.532796338690088 1.2552917446124 1.0 -0.238617036612389 0.607049719231444 1.35498919647955 0.0025837992993737 1.11637215986716 0.0108145971228295 partial_or_other True False False False True False False 1 cross_species_direction_conflict +CIB1 -0.670969639044461 0.180612718451238 0.580747619213834 -0.951111477996762 0.0427076829339921 0.391483132487066 0.188393032467674 0.601342668485781 2.0 0.0399538787104026 0.952376258663084 0.777951267238519 0.0720371624320771 0.817905145948921 0.0845615886716269 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SNX18 0.440850880891015 0.180673752184782 0.580747619213834 0.594053780861495 0.0719292853715262 0.446986106505341 1.71421395060635 1.0 0.559219495425425 0.0522558824715784 -0.328694330607485 0.181659415070761 0.23052516481794 0.37816717013423 reversed True False False False False False True 1 insufficient_or_context_specific +GRASP 0.746804215987336 0.180840840592649 0.580747619213834 0.778272367856422 0.164960143443678 0.545094551255265 0.158020468501846 0.825890531343763 -0.254530010487996 0.598858059741503 -0.0965095419861505 0.88084995301994 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCDC14 0.28861150789868 0.181043938191932 0.58081491930429 0.25479456398121 0.237421354489655 0.605329180588419 0.416014927369594 0.189858046578749 0.153349114676526 3.0 0.655735954617808 0.510723236692184 -0.795753326906248 0.275640916240673 -0.140017372288441 0.899237920743746 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KDM7A 0.251221013968712 0.181219366917246 0.581028262182095 0.0412118613963026 0.820730323166298 0.938002895863799 0.6060320702635059 0.3524915541487489 0.0614540985463335 0.0655893469676696 4.0 -0.0077842600107829 0.98386465165772 0.0104056215065028 0.97194630976355 0.0026213614957198 0.994364845687856 partial_or_other True False False True False False False 1 cross_species_direction_conflict +ADIPOR2 -0.385826931618101 0.181260165843717 0.581028262182095 -0.341903487522679 0.237554481486477 0.605329180588419 -0.213835535269927 0.571260009125509 1.04095947831074 0.0058754781246022 0.827123943040816 0.0221091527409423 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CCDC112 0.610334608610581 0.181556704706454 0.581399966117907 1.128692497872 0.0147401486029961 0.318578149070925 0.284416896952055 0.746568837784485 -0.494056146618973 0.415252582378345 -0.209639249666918 0.799042925929362 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RIOK1 0.384575819432311 0.182890951948918 0.583020130035228 0.392499063686552 0.174909858554903 0.556905394035785 0.12185633006766 0.788755922871072 -0.575709295043897 0.0901124751054193 -0.453852964976237 0.213300161146357 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAPK1 -0.184793525423694 0.183100727122655 0.583160626534234 -0.0325905525031499 0.820356200335444 0.937879887725135 0.301185316005923 1.0 -0.0638867181028595 0.818458856881891 0.666863027084617 0.0062043014223429 0.602976308981758 0.0148644136493713 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ATG4C 0.31903835851672 0.18330482106093 0.583303332199564 0.434317422643359 0.0647065730664685 0.434440024660897 0.170609458233626 0.54197599541736 -0.337848509958212 0.13316453709146 -0.167239051724586 0.502344794099087 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EFCAB14 0.314674348515305 0.18337357855889 0.583303332199564 0.557917515451119 0.0182392679821851 0.32629129734252 0.531307200423746 0.0326610974828228 2.0 0.0768110262889841 0.865061336425383 0.0075452466155639 0.983989591500095 0.084356272904548 0.821650651175632 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CBR1 0.474276195277618 0.183421771443697 0.583303332199564 0.504359095515801 0.15737268818332 0.540866159452961 1.00013176284027 0.0183932811700373 -0.918603526781767 0.0158844015270711 0.0815282360584986 0.851524650863614 reversed True False False False False False True 1 insufficient_or_context_specific +ATPAF1 0.273221421296664 0.183875576553952 0.583734220425451 0.336906363082734 0.101324069295492 0.478335084675213 0.0842301723967373 0.911240264788933 -0.0146838229714712 0.979626148459674 0.0695463494252661 0.913019706917802 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VPS37A 0.297006457376324 0.184481459058815 0.584034556144819 0.251661467680603 0.263051713216204 0.625940948419355 0.0513896959216339 1.0 0.0073086134625707 0.982269854406272 -0.293750828595991 0.19169133034125 -0.28644221513342 0.229092124066159 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NME7 0.284920843489918 0.185066894708263 0.584660764311743 0.308037463077698 0.150088724480846 0.533583468169136 0.0494636792144202 1.0 0.448928168513464 0.351436438498098 -0.166822784961623 0.679963165202719 0.282105383551841 0.534760010577173 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TEF -0.537447354791801 0.185562364718214 0.585646422550017 -0.477268125956466 0.244987771476164 0.610669341516615 0.4843536955336271 1.0 0.614501188026439 0.14059859534604 0.164121013694909 0.659889891251739 0.778622201721348 0.0549703435601174 partial_or_other False False False False True False False 1 insufficient_or_context_specific +G2E3 0.250103075680547 0.186324337063699 0.586479847450418 0.417535017326859 0.0241227190124156 0.349408136686844 0.295665082349146 0.369649684210199 -0.805438955465536 0.0128230976444181 -0.509773873116391 0.105127864146187 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VRK2 0.251250706030884 0.186442458258392 0.58654930700003 0.314906350432949 0.0926038279215276 0.472460751419842 0.0567949479258728 0.928457635800105 -0.272292358489089 0.497927880185292 -0.215497410563216 0.655381873926735 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UGGT2 0.198320025917905 0.186545104137315 0.586583367495856 0.301122202313782 0.0403966487828147 0.385111171075935 0.238896652075191 0.507329454565458 -0.715020975625047 0.0262418134915809 -0.476124323549855 0.145242658861523 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MFSD2A -0.893889543910439 0.186871983156079 0.58665603364206 -1.02329942711369 0.12403210138615 0.506117936752985 0.293916595129968 0.684302725098173 1.40018221285989 0.0132242980310499 1.69409880798985 0.0117121665914059 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SSH2 0.195105143593961 0.186998875620275 0.58665603364206 0.109804951774021 0.461960789115187 0.769126302007068 0.330937461162413 0.09844581265118199 2.0 0.295876314209668 0.630611539717116 0.0989211222849321 0.849564180264112 0.3947974364946 0.446107647749676 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SNAPC3 0.2609388059222 0.18761931975302 0.586844239050912 0.146583522918473 0.454081173093637 0.765695541335292 0.491664897194258 1.0 0.180684466874892 0.550205993416449 -0.480528553784245 0.0622160875766622 -0.299844086909354 0.251030608411948 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KCTD10 0.32756586260878 0.188024078887931 0.586844239050912 0.0496124758242624 0.849801237350321 0.953127856970211 0.3863752288278329 1.0 0.36800826937395 0.396911871643237 -0.517901466117207 0.15631878301239 -0.149893196743256 0.727012773943272 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AKR1A1 -0.340726556771373 0.188242552411297 0.586844239050912 -0.223723486942058 0.388743604441316 0.721906173483826 0.520546821727164 0.0255374050145775 2.0 0.352258585587299 0.370324089526278 0.391420892955327 0.245325592619059 0.743679478542626 0.0482135438555345 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MCM6 0.549325891729314 0.188295684249758 0.586844239050912 0.214370246660539 0.605276239874541 0.846536831447265 1.2649174496887 0.05160313481357 -1.06543639976834 0.045442236892469 0.199481049920354 0.775859332274316 reversed True False False False False False True 1 insufficient_or_context_specific +EMC7 -0.352039032581161 0.188359458336225 0.586844239050912 -0.305119373162045 0.257694294949948 0.621906676979798 0.236100448850131 1.0 0.0789483852051256 0.837782262920856 0.402880503739482 0.141591866093186 0.481828888944608 0.0995956133651801 partial_or_other False False False False True False False 1 insufficient_or_context_specific +APPL2 0.271607137141613 0.188393708706415 0.586844239050912 0.10683167136119 0.61261458950266 0.850155735537472 1.23493732283682 1.0 0.493330208742135 0.0982306692466134 -0.332415038548952 0.198782071903694 0.160915170193183 0.575674716321094 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CORO6 0.97658601464837 0.188637982676339 0.586844239050912 0.0341989824012629 0.959789856634526 0.988617762369409 1.03247920174768 1.0 1.39949266991016 0.0296420112408737 -0.646002696724605 0.165089954985915 0.753489973185554 0.207496333256401 partial_or_other True False False False False False True 1 insufficient_or_context_specific +USP37 0.295683652741579 0.188835341868621 0.586844239050912 0.375517942052929 0.0891659574663 0.470236852611986 0.0708624752974701 1.0 0.156639420343639 0.715407116185129 -0.567074126614265 0.0894215416185963 -0.410434706270626 0.253368105007825 partial_or_other True False False False False False True 1 insufficient_or_context_specific +STIM2 -0.375581355565025 0.188960104608862 0.586844239050912 -0.125708654180777 0.662847311106933 0.874027964364555 0.192086748822005 0.553409182338267 0.428165013279335 0.0905319287069486 0.620251762101341 0.0360013361442554 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RHEB 0.246382598304418 0.1901829127828 0.586919294801005 -0.0298055768746721 0.885327853122598 0.963081098449005 0.19007964427356 0.504322021837349 0.486127318944862 0.0457773928225855 0.676206963218422 0.0178433403612881 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TTC8 0.310607441305027 0.190520873436356 0.586919294801005 0.309588129409862 0.192331865314441 0.570885363891703 0.348706772636929 0.0286542130257451 2.0 0.476741823589088 0.358356614683552 -0.0785044197800886 0.865041246271096 0.398237403809 0.399832539986537 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TTC26 0.556570816950922 0.190844199351185 0.587101706512182 0.510349682901138 0.232202509625635 0.602195334480623 0.466965520150097 0.624635740416431 0.463240482815595 0.439132600032334 0.930206002965692 0.22144388111188 partial_or_other True False False False False False True 1 insufficient_or_context_specific +COL5A2 0.336254836661589 0.191142751798305 0.587506600723872 0.414217613608856 0.100882318986346 0.478335084675213 0.888556156843614 0.8450670588735999 2.0 1.55582356500595 0.0081225200288422 -1.37400300027883 0.0102278142127308 0.181820564727127 0.734065169979634 reversed True False False False False False True 1 insufficient_or_context_specific +RTN4RL1 -0.644409183364243 0.191347547636506 0.587797669936441 -0.722966103696977 0.138069051873676 0.523810858054217 0.328568325427373 0.316080768358649 0.892252569362247 0.0054451042448924 1.22082089478962 0.003250015957826 partial_or_other False False False False True False False 1 insufficient_or_context_specific +AGPS 0.299858209726601 0.191348796322367 0.587797669936441 0.378369991056599 0.0983341410082636 0.478125555523304 0.554367293120073 1.0 0.426755275337787 0.301132840267642 -0.485228249490729 0.156508447172908 -0.0584729741529423 0.89706283302159 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NDC1 0.352022193843689 0.192025043736997 0.589360584818376 0.0855651733546238 0.75862749532761 0.915381610933589 0.608342607001688 1.0 0.583123941886864 0.188898504104919 -0.768002026026274 0.0498672413336228 -0.18487808413941 0.688867301849502 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EID1 0.405014770306837 0.193949368202077 0.592191366457868 0.595954824329223 0.0564154284625443 0.423637335496119 0.0225758474612066 1.0 0.961085584535224 0.0048881458792429 -0.607473256178191 0.02950120671519 0.353612328357033 0.197972262980711 reversed True False False False False False True 1 insufficient_or_context_specific +CNOT11 0.263419444909091 0.194532358706218 0.592331237446358 0.0676096331834634 0.745397961589974 0.909500945159707 0.101513170709201 0.752356269229539 0.286030428004208 0.21098725054197 0.387543598713409 0.127373017460255 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HINT1 0.401952873290494 0.195007670360277 0.592657162827807 0.182319404542173 0.556806801188702 0.820941061653668 -0.0787423763351762 0.894159349094376 0.967865332865483 0.0265330988034598 0.889122956530307 0.0475577653060964 partial_or_other True False False False True False False 1 cross_species_direction_conflict +PPP4R2 0.227605905680816 0.196530507422201 0.594947685821713 0.414116406539611 0.0171710151637052 0.326204572615871 0.100118397674177 1.0 0.306224956220895 0.325373713331149 0.161872574997218 0.541410952130925 0.468097531218113 0.103724522165949 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATG2B 0.179396126842004 0.196626955805633 0.594947685821713 0.11158955121298 0.420322413238412 0.74234928721498 0.04937005476125701 0.0698538627673195 2.0 0.206869334608787 0.507323694706715 -0.0149684579574664 0.959097388016661 0.191900876651321 0.486356389872667 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PUS7L 0.248961032832144 0.197040811639384 0.595510601566521 0.323586050666405 0.0933360889138033 0.473315286624368 0.623405078306224 0.458802094639677 -0.219255394555587 0.724867048404529 0.404149683750637 0.609786184118634 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LMBR1 0.239848965812792 0.197251446753388 0.595510601566521 0.345217256955841 0.0622948808370489 0.431813959784778 0.274204667254526 1.0 0.424713472587806 0.342049345403792 0.101679195031192 0.78496531005561 0.526392667618998 0.191822458982586 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCDC174 0.247987595065722 0.197299603829749 0.595510601566521 0.222425098045459 0.251452553681383 0.618324208299677 0.0134704497734304 0.969813975926943 -0.671289309706468 0.0164331170077147 -0.657818859933037 0.0256044158332625 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NDUFAB1 0.378143831005659 0.19748647911826 0.595561909891628 -0.123502905626373 0.677720752524817 0.879886294337383 0.176073911297523 0.589184956781256 0.70126511465409 0.014781317215436 0.877339025951614 0.009204740002413 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RFX7 0.281481081207005 0.197562988898486 0.595594596255438 0.382619347332248 0.0766192259317488 0.455668688469891 0.34796993300793 0.360570251267443 -0.250405790202519 0.416429267376065 0.0975641428054109 0.800849263449104 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RFC3 0.366279505869841 0.197779376252279 0.595594596255438 0.0757418721802641 0.785657749323736 0.925985099057825 0.623722908410492 0.205814568733279 -0.932360992572892 0.0349923604746569 -0.3086380841624 0.545405207903267 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCT7 0.434633876528026 0.199242191028939 0.597564011229562 0.399866174895599 0.238878730560077 0.606415397271769 0.0696734413527988 0.871503703809376 0.273627907845943 0.348115643905526 0.343301349198742 0.276076145829982 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RMND1 0.269059503632562 0.199282334110559 0.597564011229562 0.159554639115481 0.453944273503732 0.765695541335292 0.118957658898717 0.765439587244565 -0.293220530827063 0.306797988624398 -0.174262871928346 0.60162564707594 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ELK4 0.310923527090835 0.200165020024977 0.599870077043346 0.390517526342862 0.10296837601077 0.479239170340314 0.541223246981696 1.0 0.0235935269657746 0.946953524990736 0.344086334914122 0.140028664244673 0.367679861879897 0.139389244002259 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ECT2 0.631138962325685 0.200349424484485 0.600252333628601 1.37270281069318 0.0112165463561632 0.302570357129259 2.56812988416235 0.0239241524942734 -1.82239756388111 0.0274208226545536 0.745732320281237 0.553675763889084 reversed True False False False False False True 1 insufficient_or_context_specific +SATB2 0.253563337771931 0.200954729180183 0.600998553180442 0.346920008346086 0.0746089882124499 0.452862231765951 0.14793217139178 0.861279616670755 -0.203364885135395 0.717981479287586 -0.0554327137436146 0.941040864830435 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PSMD8 -0.373989609298309 0.201413536410531 0.601719656002047 -0.448737901720393 0.12284568945738 0.504082700851544 0.111082461049625 0.719613875028914 0.436262526284116 0.0697151824703974 0.547344987333742 0.0405196423106954 partial_or_other False False False False True False False 1 insufficient_or_context_specific +LY96 0.554585782693258 0.202499151824236 0.602883734490867 0.446915380333629 0.310463641936502 0.663859170276241 0.0948354331962418 0.839994882962153 0.0746555334547898 0.825084603119624 0.169490966651032 0.645165077353698 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PAWR 0.380852295352411 0.20255774390497 0.602883734490867 0.0147210979168657 0.963076467133923 0.989935386867005 0.265541492831066 1.0 0.280585407663173 0.282664389188681 -0.0716133274216102 0.765881071112545 0.208972080241563 0.382490927502614 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SMUG1 0.37144948795438 0.202617476438039 0.602883734490867 0.54558080000593 0.0685441554669961 0.438244764077482 0.811411795902182 1.0 0.359224934977157 0.448706517317112 -0.235227083885823 0.526073746179097 0.123997851091334 0.793257914784406 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CDKN1B 0.322726473565771 0.203370299976086 0.603563805533091 0.187265898897503 0.450611531007754 0.763947905803589 0.0180020746141101 0.956175172604972 0.244006889184859 0.264748353003285 0.262008963798969 0.257600723001945 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HPS5 0.409879929767798 0.204104545741064 0.604525707500404 0.230177849045676 0.461795059415562 0.769126302007068 0.0830096434053228 0.809362291417351 -0.503126341759997 0.0520827378061184 -0.420116698354674 0.120257271517589 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MFF 0.281364377504006 0.204193194503764 0.604563025117987 0.432541994339665 0.0457837675753851 0.396773518009333 0.031207199946273 1.0 0.0635648094154796 0.859070568791721 0.0154320031594614 0.95668527601144 0.078996812574941 0.787599022017731 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RASA2 0.217219484850021 0.204545708608605 0.604855708155356 0.316334224861955 0.0639994831116943 0.433423054966818 0.226567734041838 0.669560203579851 -0.774574655384633 0.0667801896375692 -0.548006921342795 0.231740987372572 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FXYD1 -0.618799564914182 0.204578493447886 0.604855708155356 -0.421616359064769 0.401664558965868 0.730970076414215 0.637150166927884 0.5986414847495579 0.0116392155347595 3.0 -0.857717667986861 0.0082018547692909 1.30864071554876 0.0011098963407379 0.450923047561899 0.0968759766082303 reversed False False False False True False False 1 insufficient_or_context_specific +ZDHHC5 -0.240302999420576 0.204683868888068 0.604997840907116 -0.268835224122901 0.155240293041587 0.539558215777 0.061325088365862 0.862435148401668 0.896341828709108 0.0041282960753207 0.95766691707497 0.0052016961317126 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MXRA7 0.249686907492189 0.206056662377488 0.606215719866877 0.0771197836580953 0.709812047915452 0.894500642532718 0.7863972579502121 0.301697674004134 2.0 0.799701121089627 0.0159483266356864 -1.0482647421447 0.0038510740420548 -0.24856362105507 0.388810272428763 reversed True False False False False False True 1 insufficient_or_context_specific +MOB1A 0.333784662865424 0.206533832432883 0.606560278950315 0.532838402000219 0.0495040935168604 0.404880644205143 0.0328777479903759 1.0 0.229431861855184 0.454899803577486 0.11844350976189 0.643204925926739 0.347875371617074 0.196081456563688 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PDE1A 0.446310667733276 0.207078214296733 0.606869006043246 0.42298285998323 0.232614066239014 0.602604162857471 1.12070728100956 1.49189670352648 0.0523245048327916 3.0 0.158676266482142 0.640683658589515 -0.191752261122384 0.472959061811564 -0.0330759946402425 0.921572450373562 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ECSIT -0.361687598054877 0.207294400481139 0.606869006043246 -0.479672000264254 0.0878921922310353 0.468622105620855 0.93154308316325 0.7715848304086791 2.0 -0.0508444295073415 0.909943775171077 0.629001422792385 0.0436718087936593 0.578156993285043 0.0767117584130184 partial_or_other False False False False True False False 1 insufficient_or_context_specific +KIF2A 0.227195144454479 0.207477159461929 0.606869006043246 0.149179909154459 0.407999463260473 0.734593849437939 0.101296377191698 0.813721649956029 -0.568731017212004 0.0703518890503919 -0.467434640020306 0.169545201600429 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZFYVE1 0.270082435813769 0.207544664009352 0.606869006043246 0.159394288773466 0.46051514897007 0.768745132096508 0.124318135088845 0.661386573767127 -0.21920723537366 0.322285455025229 -0.0948891002848154 0.709113721153133 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RYBP 0.282852863829481 0.207636470308875 0.606869006043246 0.344720899272101 0.121573929533214 0.503485437181972 0.495599593537715 1.0 0.044663109720534 0.935285427653295 0.147162503259339 0.683534607642019 0.191825612979873 0.636594114880455 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PLCL1 0.396049644648695 0.207726807796113 0.606869006043246 0.641349970303241 0.0356710834125987 0.37720666979567 0.0929383565335186 1.0 0.0316920157897981 0.96623304819174 0.18608356168899 0.714442610511536 0.217775577478788 0.707817693821871 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC30A6 0.235577677419006 0.207840363366251 0.606869006043246 0.181396356581152 0.334502327573151 0.684300634473422 0.157999212979727 0.774555303144519 -0.69650460352871 0.0900241407060629 -0.538505390548983 0.234577314010965 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ERH 0.398330691438992 0.208052736572254 0.606869006043246 0.32212353364959 0.305344716377579 0.661434040934444 0.0455203199083876 0.935331104162104 -0.242833517570797 0.503841513382927 -0.197313197662409 0.644387650688514 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM132E 0.818812799587169 0.208269781187111 0.606869006043246 1.37081336600056 0.038389955440899 0.379484931484566 0.9718616307023779 0.0384055279654656 2.0 0.0317732016921525 0.966509885585696 0.051906422674784 0.924970154135666 0.0836796243669364 0.895708945356197 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMUB2 -0.481167234209506 0.208843589025283 0.607597303094223 -0.541882204790007 0.151592197247286 0.534332907346501 0.462236195069277 1.0 0.486513821241272 0.116784284019005 0.290341766666264 0.249564270176896 0.776855587907535 0.0183249855806438 partial_or_other False False False False True False False 1 insufficient_or_context_specific +KLHDC1 0.236460041808417 0.209523315824955 0.608903707261183 0.0547958728401276 0.771507869145196 0.920641521976153 0.382973976113439 1.0 0.58888412143053 0.552892169078678 -0.485740551184678 0.48898425964585 0.103143570245852 0.92246793291645 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PRDX4 0.402714327988965 0.209919802608484 0.609679124369065 0.295161431416812 0.362006409617846 0.703533322359016 0.00759113917782241 1.0 -0.0241021317264763 0.965182421862033 0.692394658886343 0.0719398765235822 0.668292527159867 0.0973820646783561 partial_or_other True False False False True False False 1 cross_species_direction_conflict +BLOC1S2 0.364494434172767 0.209981389549458 0.609679124369065 0.458533597730517 0.109145301139096 0.485176912870447 0.519361222900934 0.0674209734718208 -0.593330753867069 0.0259922179534556 -0.0739695309661351 0.801598103376811 reversed True False False False False False True 1 insufficient_or_context_specific +KIDINS220 0.20332744756374 0.210474289259607 0.609746666798533 0.341253913023708 0.0317972938722167 0.375031405408838 0.162605081573084 0.48851729371843 -0.257841994959125 0.18452097824244 -0.0952369133860405 0.665605284879796 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PCID2 0.204614344322226 0.210680376407569 0.60991593477135 0.223309816165866 0.167114821818468 0.547439742091029 0.160437533376415 0.653396314246701 -0.414619189231239 0.132027908386916 -0.254181655854825 0.400847835825959 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RPIA 0.364852592033377 0.210910953794372 0.610409327811836 0.418152749746631 0.154875385960648 0.539282749619134 0.0144969169764184 1.0 0.0276067075111294 0.95762493377024 0.302642952551862 0.361309711323046 0.330249660062991 0.372523556216188 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATP13A3 0.322371004159097 0.211160551892952 0.610643646164135 0.300418703574896 0.245481959408894 0.610841038755386 0.160541051109247 0.0586074668242394 2.0 -0.0625316276552295 0.869015643979454 0.565381541594662 0.0443916191688037 0.502849913939432 0.0808991989123925 partial_or_other True False False False True False False 1 cross_species_direction_conflict +MAP7D3 0.268158480741902 0.211413589969421 0.610643646164135 0.199428492776131 0.359725153189121 0.702743831320045 0.354900128596688 0.68292682811003 -0.15658593569849 0.802852945356682 0.198314192898198 0.805710834123298 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CMPK1 -0.237037848066007 0.211539806032876 0.610643646164135 -0.0324964278692313 0.869852246316099 0.958502690861149 0.504815168291601 0.193010785431213 0.749140074255021 0.0276669234701342 1.25395524254662 0.0060040539419251 partial_or_other False False False False True False False 1 insufficient_or_context_specific +COX7A2 0.462741007071135 0.21173927399816 0.610643646164135 0.60874410008195 0.10240440661367 0.479137456027696 -0.294615387402264 0.585236547913621 1.44986654306209 0.0051091206920605 1.15525115565982 0.0206212459289334 partial_or_other True False False False True False False 1 cross_species_direction_conflict +PSMD11 0.211616329523299 0.212081403479692 0.610643646164135 0.104410014192394 0.543513007498889 0.814659839122782 0.319774931891721 1.0 0.108809353161256 0.784947378045873 0.386619038622679 0.18829643890221 0.495428391783935 0.115609848279306 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RLF 0.250681897703237 0.21225839758385 0.610643646164135 0.376976348611108 0.0562475644493232 0.423380157386529 0.690815642912475 0.0569783983289279 2.0 0.233824075426303 0.516781762755295 0.140571787451401 0.625244426542908 0.374395862877704 0.226405590433326 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FBXO36 0.332394674790027 0.21233733787511 0.610643646164135 0.106390441477662 0.699472450720573 0.889762666832267 0.0647724572908186 0.945779519921482 0.71990777029383 0.163941054263686 0.784680227584649 0.204637880572879 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GPR137C 0.588665975172712 0.212477771002419 0.610643646164135 0.0495309753666269 0.917081921724447 0.975930957742715 1.59121116577817 0.116539539891223 -0.529755930395449 0.425334001635488 1.06145523538272 0.284213165291042 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DHX57 0.343174360870269 0.212644273165648 0.610643646164135 0.240545388142524 0.375884837876552 0.7132826228158 0.0322365180238315 0.947625882725556 -0.623687757106982 0.0646185894376236 -0.591451239083151 0.101199352629115 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KLF9 0.66017365581031 0.213797613212303 0.612280544751707 -0.0445586684115504 0.933071047075875 0.981085441734921 0.176335386333912 0.578997240638552 0.267464635807571 0.161968246495651 4.0 -0.853797411269254 0.0577091094285948 0.710701551762521 0.0781598317302911 -0.143095859506733 0.74613703591999 reversed False False False True False False False 1 insufficient_or_context_specific +PRPF19 -0.350743787461529 0.213932840461171 0.612280544751707 -0.33846201658029 0.231550320461181 0.601518427890281 0.0724499155120945 0.814653406210822 0.599970673674293 0.0166157010912009 0.672420589186387 0.0150023143202489 partial_or_other False False False False True False False 1 insufficient_or_context_specific +API5 0.208106396547952 0.214271731549027 0.612586228457792 0.191318736550268 0.253632672420877 0.618991529980024 0.0310520406563677 1.0 0.0422286272398831 0.884489281729961 0.269397003335197 0.17048795637518 0.31162563057508 0.140844622508071 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PGM2L1 0.415696274959071 0.215759845552342 0.614676861668006 0.331289770552122 0.331406270063423 0.680349234702553 0.0294337610268938 0.967610304956895 0.40669460225705 0.35603275839058 0.436128363283944 0.391579376108947 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MED13L 0.257251815910844 0.216716338573711 0.615410592907224 0.294808421179782 0.153874088712729 0.536703874670957 0.337777438740549 0.384793333846943 2.0 0.371228584105404 0.259736012744498 -0.269602387307731 0.342551241210756 0.101626196797673 0.761480617830214 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CTPS2 0.221109913652679 0.21790466416618 0.617620790407123 0.329447890425444 0.0556295054783031 0.421331649096072 0.369728403722271 0.233991421396858 -0.281661449711828 0.284635847796219 0.0880669540104426 0.783370270625946 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BCAP29 0.300363365807555 0.218753589050921 0.618140683181076 0.546683914907395 0.0146469727132284 0.317541556275699 0.0957750937584614 0.860184763130935 -0.116206519605499 0.7597613918515 -0.020431425847038 0.967042508196636 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FBXO42 0.24704540641278 0.219818938623327 0.618805736983134 0.032595686286185 0.869718726463874 0.958502690861149 0.161789590732584 1.0 0.103532374279768 0.787647587732967 -0.0090568963963135 0.977708325884983 0.094475477883454 0.776560501809025 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NAA50 0.243989288908983 0.219846489080086 0.618805736983134 0.189565710621918 0.346976497831587 0.691856064986949 0.0942541526070501 0.0418885461767697 2.0 0.0775673330344323 0.830261829930927 0.306759183958914 0.219191496108599 0.384326516993346 0.155436477540401 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SEPT11 0.31766937073242 0.219888232404146 0.618805736983134 0.469910527078829 0.0651474324057082 0.435515719106489 0.45996752766158 0.140863747592866 -0.0918161402505563 0.752688866244041 0.368151387411023 0.201706956378446 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SCAMP1 0.334279743225336 0.220071550877739 0.618805736983134 0.469995931759613 0.0832581873513006 0.464737806591834 0.511190950658748 1.0 0.0988602035719043 0.78068603274094 0.196506598998968 0.439602111994184 0.295366802570873 0.284514590997784 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IFT74 0.231753668825798 0.220175435470034 0.618805736983134 0.167500531042952 0.384316084519042 0.719298323474503 0.502879126725192 0.303150116351028 -0.126820402806392 0.760473935669188 0.3760587239188 0.402954108447658 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SP1 -0.225332599347981 0.221243282559747 0.619136893428193 -0.290959486878776 0.0996399375836049 0.478125555523304 0.201645273333141 0.280107895260356 2.0 -0.155596948058786 0.612055771718481 0.618776783510661 0.0192121694799945 0.463179835451874 0.0772470420820813 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MAT2A 0.385802867938414 0.221693328512399 0.619544246276842 0.301209177262395 0.342190682302771 0.689130402583821 0.046634466387377 1.0 0.351939838517196 0.233658535785586 -0.418804878289938 0.112702940281189 -0.0668650397727413 0.82694027862204 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CEP128 0.228439317733503 0.222906284410541 0.620868658128427 0.299925554710229 0.109063038567948 0.485176912870447 0.733151436298202 0.19059854471875 -0.744426300735634 0.113114894396859 -0.0112748644374317 0.986427229247701 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EIF3E 0.247033353020271 0.223049837455509 0.620868658128427 0.427470098055563 0.0267422093937599 0.356222495883986 0.0571074950538729 0.0782778177919057 2.0 0.0948004211399062 0.880405189256599 0.0213374328463267 0.964958184684855 0.116137853986233 0.822378917549632 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PTP4A2 0.218496319185242 0.224075348439579 0.622248166445313 0.147031489126209 0.40952881022122 0.734946310126928 1.16155387084939 1.0 0.190503897658747 0.52474465838118 -0.126701480311523 0.609036984959103 0.0638024173472244 0.826646519991694 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ST13 0.27709909347236 0.224518557977151 0.622406722094687 0.428817449170767 0.0558624937328985 0.422187694224726 0.6837381265812551 0.48408004974043 0.0324800960524175 3.0 -0.406558961240047 0.235056249170356 0.941605970501284 0.0084536844581115 0.535047009261238 0.0923888670855275 partial_or_other True False False False True False False 1 cross_species_direction_conflict +SSR2 0.343526865570236 0.224681304911913 0.622406722094687 0.377818485736346 0.182929389138262 0.565223438841605 0.0275903884160001 1.0 0.0039557187653829 0.992862411288349 0.303355367074592 0.284212938333775 0.307311085839975 0.307139007381209 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RC3H2 0.205527689109895 0.224721957248053 0.622406722094687 0.096180448570001 0.557020414027762 0.821027716222967 0.156461407542237 0.497736066625031 2.0 0.433096508249293 0.0797928308315593 -0.184554299688957 0.375355474683143 0.248542208560337 0.27630589135616 partial_or_other True False False False False False True 1 insufficient_or_context_specific +STN1 0.48013594853643 0.224840451547536 0.622571593873299 0.0702799941959336 0.854773847629987 0.955390667104966 0.471914885628509 1.0 0.199982787923302 0.658278559854219 -0.638987640109763 0.0777150712267982 -0.439004852186461 0.253189393674857 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCDC6 0.263738125275594 0.22515305430688 0.623217585773721 0.256122327977169 0.239657921892842 0.606713331305531 0.668846100956606 1.0 0.0295014931925537 0.935331104162104 -0.583142033048007 0.0304953073040953 -0.553640539855453 0.0451960799512713 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NDUFB9 0.309975327298336 0.226602350257214 0.624339147707637 0.360902259060059 0.160263084828984 0.543541307772207 0.429245805782367 1.0 -0.545358947787989 0.250887104609458 1.27645017019485 0.0102391053289871 0.731091222406863 0.098633744377413 partial_or_other True False False False True False False 1 cross_species_direction_conflict +WDR36 -0.275481427980848 0.227678357946696 0.625020307644621 0.0710594822261266 0.743978588009076 0.909384383019378 0.522987113586772 0.147166379095051 0.192103091940336 0.508128470436538 0.715090205527107 0.0424768150940576 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TMEM161B 0.213556532446527 0.22876324495814 0.626535943428939 0.044172073968275 0.805465141401974 0.932569466270648 0.0866651011464833 0.856860196217495 -0.313292573468282 0.337318213560175 -0.226627472321799 0.541363225916492 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC35D1 0.229021514418755 0.228894476878849 0.626584632238916 0.207322513029714 0.279812956793726 0.642114507827558 0.0341541246805635 0.101783927680322 2.0 0.067061759873476 0.82230231866273 0.0196907139628223 0.937152788448495 0.0867524738362983 0.722339331922986 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RBM41 0.232213732730741 0.229450205694563 0.626787909889572 0.113651009668993 0.564173101856429 0.823754286312897 0.335573452445967 0.382327866974021 -0.630549494073186 0.0590843310313042 -0.294976041627219 0.409509530854742 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AGMO -0.603279058879223 0.229620858680044 0.626929667945154 -0.538740384512742 0.285488237212112 0.646550274691695 -0.442156860475492 0.157294062265359 0.969192718988396 0.0045440964990252 0.527035858512904 0.0705545064953378 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SEPT2 0.194462121292038 0.230140335799646 0.626974093492763 0.223163933465958 0.163973960388602 0.544850245278 0.129855915481792 0.64023679664879 -0.0493392922191184 0.839040118304251 0.0805166232626735 0.75143573650664 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MMP14 0.329643047732016 0.230460278258699 0.627434968079753 0.326566967938044 0.23536288960698 0.604613476513503 0.586158459710836 0.574077879987831 2.0 0.994715022099073 0.0012104068554188 -0.68542601748534 0.0069628006375834 0.309289004613733 0.163828807437533 reversed True False False False False False True 1 insufficient_or_context_specific +IFI44 0.355136781473481 0.232396530412719 0.629785053413111 0.256320146658888 0.393777738155273 0.725496396938757 0.955079204491664 0.196548048915075 -0.217376431979472 0.700043498049031 0.737702772512193 0.28948953379064 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PSTPIP2 0.377461741676842 0.234643903372336 0.633274624694561 0.036973831906752 0.906655646701053 0.971134251584632 0.0168369727117446 0.971220331487005 -0.249061681315059 0.429557229784602 -0.232224708603314 0.517547452823532 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPTBN1 0.220923382820748 0.235421157848446 0.633752316308997 0.236963138825891 0.20072574085943 0.575734603933236 1.11376214217847 0.0983272905844776 2.0 0.112323477472758 0.737462550539414 -0.0360392704648014 0.904387017949864 0.0762842070079568 0.798833221094232 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATP6V1D 0.306527174327667 0.235618732487863 0.633960901530801 0.325367756688846 0.208236678634482 0.58080491821533 0.157299558050947 0.552892169078678 0.0795784003389875 0.719587263908569 0.236877958389934 0.294325762660054 partial_or_other True False False False False False True 1 insufficient_or_context_specific +JMJD6 0.34864322022293 0.236063894241904 0.63418895557405 0.174809356392237 0.562358296422623 0.823511623725651 0.696333273746161 1.0 0.224892761866591 0.580906900835266 -0.734129378027471 0.0389870773095688 -0.50923661616088 0.149084972466462 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CAMK1 0.365335626784301 0.236576952609327 0.634711196312224 0.130242755216512 0.672266242807727 0.877133430257505 0.254490071050502 1.0 0.0218034916386856 0.965260864033236 -0.427503852571126 0.213327075600019 -0.40570036093244 0.264917354194965 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LNPEP 0.241216481206831 0.237079119742138 0.634812256343697 0.264474483532033 0.194378625540391 0.571343735852293 0.0145415150123617 0.962513237604274 0.0784477638369765 0.724327351091894 0.0929892788493382 0.697133192453199 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ABHD17B 0.28887331030901 0.237239305662006 0.634877181480413 0.244633839544925 0.315510715544959 0.667835231500337 0.0421767201481727 1.0 0.293803946782107 0.37997474632483 0.053360759158419 0.863118830554423 0.347164705940526 0.24713449356629 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TKT -0.324023392550001 0.237878278609619 0.635230791037838 -0.428713426239579 0.112162327641302 0.49055917781146 0.20853538230169 0.9296280592117 2.0 0.432341360973984 0.172129406616575 0.233038281881263 0.393864955388464 0.665379642855246 0.0355264612821072 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NUMBL 0.272221706923116 0.238303176649114 0.63551526624434 0.0066885995871092 0.976082062384537 0.992970766113577 0.38676795275382 0.291929911689052 2.0 0.487165226596245 0.163787701899064 -0.765905809792209 0.0222872528770708 -0.278740583195964 0.404684174809242 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AGO1 0.300725443727051 0.238754014243643 0.636396082399491 0.234030805921587 0.360063542534969 0.702743831320045 0.462087553158249 1.0 0.173331063468884 0.568560886856132 0.0473045518835686 0.859768163493412 0.220635615352452 0.395188806077642 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PTPRB 0.810437684616475 0.238954679091435 0.636609513461361 0.280862452911898 0.678405739780575 0.880157669422479 0.284354017303414 1.0 -0.116647675590396 0.773986314844316 0.682504684980964 0.0349915825809424 0.565857009390568 0.0827728197675424 partial_or_other True False False False True False False 1 cross_species_direction_conflict +CDK7 0.288467997101016 0.239836971546526 0.638315791678403 0.0804992973749615 0.744904500065145 0.909500945159707 0.436340434457773 0.0930816267389048 -0.271448303124647 0.215671093637249 0.164892131333126 0.503374028510362 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HSD17B12 0.207564738021922 0.240884628820795 0.639881966907748 0.226207139657115 0.199054203557421 0.575122356864606 -0.190361030117267 0.601131792385039 1.04344768783089 0.0043411408218517 0.853086657713625 0.0159316931008995 partial_or_other True False False False True False False 1 cross_species_direction_conflict +MYO9A 0.190691832188695 0.240910287787299 0.639881966907748 0.277760103247555 0.0811050277256313 0.461068439742811 0.362352882702745 0.0906505586533727 2.0 0.386536844722017 0.324749051742015 -0.703757032762119 0.0441635777133984 -0.317220188040102 0.394611576140553 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HEATR1 0.300623354128831 0.241221448846872 0.640162035467699 0.539576214975009 0.0268562166136621 0.356222495883986 0.053211182485388 1.0 0.326823389301194 0.320349903765884 -0.317665966500506 0.235055058198012 0.0091574228006883 0.980873751510795 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CEP290 0.241339133855081 0.241743566668373 0.640422275407584 0.281081145324707 0.172735813221234 0.553858965567902 0.0614248562662608 1.0 0.0797286288518126 0.908381786429681 -0.677799818335605 0.142274302304657 -0.598071189483792 0.25136353351742 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RPN2 -0.271896276474392 0.242451748063283 0.641246912160877 -0.106725049215659 0.645459305330483 0.867017728457919 0.520415277359204 0.4254511629262929 2.0 0.177855887251047 0.619931130061459 0.454033615122369 0.113916446776431 0.631889502373416 0.0475577653060964 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ADCY7 -0.34566485692757 0.242957416249907 0.64176742576095 -0.360082766218166 0.222964666543374 0.593969140017564 3.19929772180886 0.0002635483033429 -1.9377619563459 0.0019014954372257 1.26153576546296 0.0553499236865611 reversed False False False False True False False 1 insufficient_or_context_specific +RBPMS 0.305075732013175 0.243277944495643 0.642104721621574 0.0371713209628436 0.889131182963832 0.964276699808303 0.9230171059698249 0.678017389374427 2.0 0.0760561336244887 0.861350727931162 -0.225442614540065 0.467119941648719 -0.149386480915577 0.66451318228455 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TRIB2 0.400892941983611 0.243413345204224 0.642168440446325 0.0305313704184737 0.925431606245509 0.978485542437683 2.08768188898962 1.0 0.533272384299905 0.0966973179613063 -0.109641942528903 0.705300484876385 0.423630441771002 0.155047948809902 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CYB5A -0.42768006297855 0.244024081688813 0.642250060235767 -0.404148612151008 0.271336296980875 0.635344560550917 0.471859921262233 0.324815377445822 2.0 -0.442776025241204 0.435827243641088 1.44502424954768 0.0116261985659386 1.00224822430647 0.0586310372840311 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CHMP5 0.335436118278344 0.244137503652175 0.642250060235767 0.343319712383788 0.234232926002581 0.603031268650391 -0.143932741552853 0.590280657217666 0.93458646829284 0.0019014954372257 0.790653726739986 0.0061953616803492 partial_or_other True False False False True False False 1 cross_species_direction_conflict +N6AMT1 0.384951099602094 0.24443504598353 0.642250060235767 0.529356644237243 0.112111346023688 0.49053940792296 0.45747125129965 0.6416999731864019 2.0 0.508874165285795 0.358113220795809 -0.355467561585853 0.416829126349437 0.153406603699942 0.786667559479543 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATG10 0.30119278805476 0.244717346094927 0.642250060235767 0.312733170478483 0.22693701810209 0.599150046792164 0.7294547723412691 0.144851832142862 0.0754338921711254 3.0 0.245784837305046 0.594093355400225 -0.534104123213207 0.134350051606623 -0.288319285908161 0.48307355066571 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ROCK1 0.192618112823255 0.244783943602798 0.642250060235767 0.231857611801631 0.161228089430538 0.543541307772207 1.30315129503488 1.0 0.196498832901268 0.436865678258403 0.0427164917343934 0.857215046913947 0.239215324635662 0.283719455272511 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC25A20 -0.423625603987664 0.244916425722367 0.642250060235767 -0.311391357539803 0.398282189113424 0.728766459000216 -0.166267077908344 0.757533877261813 1.46023614969708 0.0040155626029722 1.29396907178874 0.0104682629864625 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ESF1 0.20032466991403 0.246260951618738 0.643888837838197 0.31596862036584 0.0603955791908224 0.429268745755419 0.0464156520624773 1.0 0.380744916301042 0.330981363315661 -0.336295986499163 0.295573160426409 0.0444489298018789 0.917335477477782 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCDC47 0.324098635811678 0.247087578567827 0.645192517153539 0.213398003161563 0.432224517205686 0.751057678185917 0.497826505031194 0.4023677355665179 2.0 0.0809083229895644 0.792773476679991 0.0679131766813142 0.778847583482528 0.148821499670879 0.547243484249174 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM260 0.200303704812817 0.247118275885805 0.645192517153539 0.254491539375169 0.140671420192128 0.526401063874107 0.0506263252846733 0.878398861090629 0.2883310936996 0.194078590410009 0.338957418984274 0.160057180788343 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MED23 0.182404815587167 0.247431758093832 0.645192517153539 0.175341701911738 0.263725281713979 0.626379950271573 0.124339507905399 0.731976065822699 -0.227869129948221 0.39655700629644 -0.103529622042822 0.749145409520029 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DIS3 0.204920891690187 0.2484034275282 0.646387089570654 0.210055240445083 0.235986613646182 0.604926482992162 0.617743937584353 0.170075120640627 -0.440518206199209 0.217082322438899 0.177225731385144 0.702838641479649 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPP1CA -0.430133387081666 0.248827315883066 0.646914257841274 -0.127443082649585 0.739076814860587 0.907662325380723 0.187340992369873 1.0 0.369896491314469 0.244079276398375 0.670882668554815 0.0216465274460034 1.04077915986928 0.0056959319644607 partial_or_other False False False False True False False 1 insufficient_or_context_specific +HIVEP3 0.238524687807627 0.249082324555014 0.647217814295563 0.156984570251541 0.456400216522036 0.767060408474954 0.7652087928231579 0.165092986967699 2.0 0.981548777503556 0.0188222038975691 -0.40113289397367 0.214976534815621 0.580415883529887 0.119462559643152 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KCTD3 0.214078644195409 0.249829165492576 0.648082636184426 0.0369164699872252 0.846348413426209 0.952130692483102 0.330833961940051 0.305457959657571 -0.513428599856466 0.06940398159636 -0.182594637916415 0.556946908468266 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCT4 0.340953182662135 0.249975268924936 0.648302355516943 0.456520846955737 0.12278197111414 0.504082700851544 0.337543611235645 0.0338189691320798 2.0 0.0245438007863129 0.963021145110354 0.208999873291912 0.555823079775176 0.233543674078224 0.552044056152266 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LDB1 0.288220673936589 0.251141602755974 0.649412941929359 0.279205912639057 0.266127979862507 0.628585953330726 0.398333364732684 1.0 0.159538484239072 0.631246129362698 -0.319655915606837 0.228348116405781 -0.160117431367765 0.581418494947724 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GID8 -0.259958472141163 0.252311548421404 0.651162387737273 -0.388137506044871 0.075583496640379 0.453930920096201 -0.142032756580956 0.684302725098173 0.624035028025535 0.0312593070258607 0.482002271444578 0.0952862081287919 partial_or_other False False False False True False False 1 insufficient_or_context_specific +KMT2A 0.163192369238885 0.254675598687413 0.654225053757106 0.111238797391967 0.431035247537485 0.749731489868331 0.100547394296083 0.758158147574253 -0.229147224890881 0.347277585648827 -0.128599830594798 0.638465089413867 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CSNK1G1 0.285075489792095 0.255542127730175 0.655016699338478 0.512529574932904 0.0374422837218018 0.379484931484566 0.365122397334391 0.0280612143650434 2.0 0.238879076825954 0.621250010750036 -0.471562532309844 0.203702917345677 -0.23268345548389 0.592751378551951 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VPS26B -0.261017858210583 0.25567739323054 0.655017758358997 -0.319059387683592 0.162073750565574 0.5435530180671 0.145537506176715 0.611960492564201 0.417608676359868 0.0705955773919538 0.563146182536583 0.0319522317282264 partial_or_other False False False False True False False 1 insufficient_or_context_specific +BRK1 -0.302011281327303 0.255990190230237 0.655017758358997 -0.196983349685633 0.48336350870481 0.780666906162311 0.0186893059072106 0.966145399025796 0.514661224890999 0.0918182810322519 0.53335053079821 0.098633744377413 partial_or_other False False False False True False False 1 insufficient_or_context_specific +EFCAB7 0.315809449562679 0.25619200900484 0.655092087932454 0.0872223493349559 0.754101076587533 0.913618862571469 0.202529993499256 0.846388159848326 -0.355395325142173 0.601788347105115 -0.152865331642917 0.870158170236349 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PSMB2 -0.24095168761371 0.257501133492641 0.655993524105164 -0.249331382000387 0.24000492251193 0.606794054569195 -0.338469838504804 0.288888195470562 1.02254041611132 0.0039527539399443 0.684070577606512 0.0296738774093425 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PDE5A 0.337938683079407 0.257729784316696 0.655993524105164 0.383699841607052 0.194760690439241 0.571343735852293 0.371794089171207 0.31738191177615 -0.0122795490355173 0.972450972033354 0.35951454013569 0.286319702684933 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PCCB -0.223650822314016 0.257753113854327 0.655993524105164 -0.151274330216727 0.450056991406293 0.763939182518913 -0.944241643774655 0.0179374267520533 1.71411999811462 0.0009443333152877 0.769878354339963 0.033540914967055 reversed False False False False True False False 1 insufficient_or_context_specific +CEP57L1 0.180835185918289 0.258362496343565 0.656237190870052 0.261228077773386 0.0899432158334477 0.471142565909827 0.0431568276069752 1.0 0.0373965526984572 0.962850315611004 -0.435669421589268 0.406257518049835 -0.398272868890811 0.518971288483966 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RBPJ 0.199574181364015 0.25876178263391 0.656475699466093 0.230745184495858 0.189641138099331 0.569886897607216 0.0776015249107453 0.826298295825603 0.285887981960143 0.239615881413648 0.363489506870888 0.16888455327763 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NTPCR 0.371076462774081 0.259949894729486 0.658481523165527 0.298311489561159 0.366710016876968 0.707940091092892 1.08046458748364 1.0 0.484958958590395 0.212025511090996 -0.429266559780823 0.178195365415469 0.0556923988095714 0.897249570586414 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NTN1 -0.7876967935069 0.260112080251955 0.658734311177776 -1.24779684332052 0.0615712391611522 0.430858123979337 -0.0367692136714386 0.926507226037505 0.783525540467682 0.0123528242806875 0.746756326796244 0.0206212459289334 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PIN4 0.250442647784716 0.260482292900079 0.659197518801303 0.362075664041793 0.102603794092494 0.479239170340314 0.520614596084343 0.222196232096344 -0.170334064628998 0.625843978753854 0.350280531455345 0.380272991785526 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TEX9 0.321010696235357 0.261141772566011 0.659207826690317 0.379281002237763 0.186606511785504 0.568949493235375 0.181956726943399 0.792447916806226 -0.0484209906839118 0.930620496481166 0.133535736259487 0.825805155106797 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CD63 0.324204170394396 0.261182083325182 0.659207826690317 0.599419276385711 0.0347615947996593 0.37720666979567 1.69465109276165 0.0007832524455666 -1.5165220173647 0.0017436951437914 0.178129075396951 0.630235234691682 reversed True False False False False False True 1 insufficient_or_context_specific +DDAH1 -0.484332128280419 0.261641960993742 0.659207826690317 -0.444819718653859 0.304800882457971 0.661341495477036 0.9992980296589901 1.0 -0.296945571385306 0.62571028655909 1.71993559805682 0.0041282960753207 1.42299002667152 0.0144283092262375 partial_or_other False False False False True False False 1 insufficient_or_context_specific +HADH -0.231508328307121 0.262022005216025 0.659207826690317 -0.130047227024202 0.529368117043489 0.806619797913863 0.418009577909812 0.457653667016666 2.0 -0.252917009699384 0.603562155863719 1.06414407682101 0.0173180247822924 0.811227067121626 0.0600208372052234 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RNF219 0.31099039449571 0.262060355027584 0.659207826690317 0.268455528799865 0.334226080107503 0.684000572547979 0.0282103912469555 0.966044037293488 -0.182339289250863 0.683578039004866 -0.154128898003908 0.773905942995984 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CD72 0.576994517859624 0.262109723095847 0.659207826690317 0.370012750050679 0.464741650961222 0.770230855975455 1.09911876184077 0.0826749741133801 -0.447619752059232 0.325970826626894 0.651499009781537 0.283661082583848 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TNKS 0.180538285015819 0.263769575499683 0.661334404684317 0.208033919484153 0.193398605962816 0.570885363891703 0.537826350290474 1.0 0.447981136203511 0.113128979502674 -0.143309359347031 0.560115782996674 0.304671776856481 0.243060443475451 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ARHGAP35 -0.208861261683012 0.264129590861692 0.661564835355403 -0.214940947879888 0.249328468164118 0.615192794315671 0.666472045455194 1.0 0.213491399540263 0.514114098331159 0.4667776288605 0.0840367873878504 0.680269028400763 0.0289582159980265 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GATB 0.240248692739664 0.264538510352959 0.661907208672026 -0.0391604259627008 0.853364699354833 0.955240086491554 -0.0299605166119854 0.941363125049339 0.658783957621765 0.0222016395606543 0.628823441009779 0.0390761786381651 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ID4 0.724935713250673 0.264688567960695 0.661907208672026 0.462783083215734 0.470276561060445 0.774115985605889 0.9357050666900342 1.29350865897253 0.120969336916504 3.0 0.523719934713913 0.447096610707884 0.147513134842002 0.786819216066734 0.671233069555915 0.265864145397571 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SWAP70 0.291343681577153 0.265697320935238 0.663489194520872 0.146739783063423 0.57831487026625 0.831066884479525 1.22811486987887 0.0018195703596251 -0.835432297350751 0.008687383133449 0.392682572528119 0.188758850947986 reversed True False False False False False True 1 insufficient_or_context_specific +XRN1 0.135751148868132 0.266154409815446 0.663681248836326 0.140761615723848 0.245177929396754 0.610669341516615 0.0352546357048737 0.93061952943084 -0.0960809715551231 0.732304673257783 -0.0608263358502494 0.851813705978236 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACSL5 -0.382285965078056 0.266547533777469 0.663885081769879 -0.322231656123963 0.354494827077554 0.698014991474228 0.301863293413674 0.366130266893512 0.730743034520859 0.0218199908363743 1.03260632793453 0.0071911577358735 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NENF 0.355790082018146 0.266942858998831 0.664538816849309 0.63011907522622 0.0576517001812387 0.424809475920108 0.7641254137028309 1.0 0.113620565068981 0.680138276447243 0.108157195107365 0.621319859958577 0.221777760176346 0.323463038417611 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PHF14 0.219165306748033 0.267325639271693 0.664538816849309 0.159044895160818 0.425413439324638 0.746056682180874 0.374675844012995 1.0 0.175627400792481 0.477631371002834 -0.42359752940276 0.0513399434248689 -0.247970128610279 0.254368527667434 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WDR19 0.324875134102503 0.267333206340867 0.664538816849309 0.243866477075681 0.405490018754561 0.733444811508554 0.292845930660115 0.112312612275199 0.144861403032026 3.0 0.209340305965205 0.718532327628564 0.0862183911690802 0.847154638536865 0.295558697134285 0.54272149375044 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KCNK6 0.307112644819894 0.267571440091464 0.664538816849309 0.0830184213134596 0.763505672339517 0.916866798061945 0.73415086493221 0.162528269234489 -0.331182831393113 0.416602533622417 0.402968033539097 0.421375030668737 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FMNL2 0.293912097254436 0.267714946386649 0.66459779072425 0.361818465916321 0.167678735862349 0.547623080618609 0.6100328651214001 1.0 0.670364634652433 0.060725149951687 -0.329679812696285 0.255594964821593 0.340684821956149 0.299967630431174 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PDCD6IP 0.176960568669424 0.267838673955247 0.664653070708863 0.350578370668821 0.0167997941108239 0.326051886437644 0.0464774634611826 1.0 0.0068792984379093 0.982685585789729 0.162644252817072 0.457169028547236 0.169523551254982 0.465721687600566 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TDRD3 0.152629835026589 0.268432911017567 0.665441341752401 0.166285529496275 0.224256287775502 0.596097151644952 0.539211376457642 0.054780724759655 -0.483357924268838 0.0519979268681754 0.0558534521888037 0.848856992637175 reversed True False False False False False True 1 insufficient_or_context_specific +SGK3 0.206452876533965 0.268966686582914 0.665982710352347 0.199219397207724 0.284987914346129 0.645964448189444 0.0355651968350885 0.945279748720084 -0.528442920572528 0.12732969543146 -0.492877723737439 0.18852932756456 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PCDH7 0.555203870381886 0.269150029869454 0.666195044623745 0.836760345233305 0.088298700802116 0.468706728541348 0.339728188273296 0.124481529590886 2.0 0.374055369813876 0.418699820073183 -0.675416073952043 0.0919432671476223 -0.301360704138167 0.474295673545989 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ITGA6 0.522240710767943 0.269874028523764 0.667222685933312 0.481869830595226 0.308366153215275 0.662330926800867 1.21250007350313 0.0324726924163947 -1.79481715174775 0.0036707134459979 -0.582317078244617 0.325931132695336 reversed True False False False False False True 1 insufficient_or_context_specific +NAF1 0.273970055731417 0.270304592861787 0.667448704252917 0.109265818924771 0.66244667755304 0.873717928995002 0.0533445509015257 1.0 0.0245327286505557 0.977035535470038 0.513367571699999 0.292660902721878 0.537900300350555 0.350170625890853 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NHLRC3 0.263843099114632 0.27053756060548 0.667448704252917 0.184151145657822 0.445844302651172 0.761071002003407 0.7682367228784291 1.0 0.0922065163434298 0.885148266645914 0.395392192142707 0.298793712970639 0.487598708486137 0.276011964523011 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VPS35L 0.176870468698947 0.271712935317387 0.668772996929307 0.115436748085456 0.475121874722526 0.777182934458493 -0.0769818898912614 0.829658625351641 0.61257536372662 0.0236134082646507 0.535593473835358 0.0538286229571822 partial_or_other True False False False True False False 1 cross_species_direction_conflict +SLC25A40 0.402966347387041 0.271954507855482 0.668772996929307 0.420539832351782 0.253311214057235 0.618991529980024 0.598102952285146 0.317934656023734 -0.434833452017959 0.353757529478003 0.163269500267187 0.794363363534158 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZMAT1 -0.312994128475824 0.272106140853688 0.668772996929307 -0.220121325510231 0.444155768794667 0.759994423711047 0.60218667851689 0.275318446615057 0.698836159981863 0.0823098419703391 1.30102283849875 0.0192797801662944 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RSF1 0.196856022609611 0.272712847108895 0.669025090444419 0.175670884514405 0.327488401770985 0.676889991422347 1.23516252147142 1.0 0.168793827720536 0.610199120926901 0.0215662098368092 0.941956726225613 0.190360037557346 0.50413283499357 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TXN2 -0.338427143562047 0.273486186423383 0.669025090444419 -0.545628046515001 0.0850257530560723 0.465854644922683 0.426752539872616 0.491307782102565 2.0 -0.142965589548054 0.787386202931747 0.976898909674607 0.0226156610485279 0.833933320126553 0.0526820030853168 partial_or_other False False False False True False False 1 insufficient_or_context_specific +BTBD3 0.317105897505453 0.273537813239034 0.669025090444419 0.20676301377946 0.484016986501588 0.780666906162311 0.546494071212648 0.33889225571971 0.152307935797454 0.730962658669003 0.698802007010102 0.173807826872228 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM45A 0.302856460638457 0.273862294111467 0.669309995509484 0.40508206429192 0.142442170913282 0.528011532230573 0.0823968790934084 1.0 1.84924404039601 0.0080989648790917 -1.1589742524025 0.0218847753945068 0.690269787993513 0.278827429544645 reversed True False False False False False True 1 insufficient_or_context_specific +FEM1C 0.50068853121847 0.274562415875379 0.669664741099049 0.186461420730385 0.680871586796229 0.881177030325396 1.31273017860629 0.8105303892980409 2.0 0.430680747874963 0.413197617724149 0.0397991940750015 0.930019262724888 0.470479941949964 0.312983626018603 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IFT43 0.223589339629608 0.275633558118689 0.670442829737156 0.186289900838334 0.370410505551226 0.709891834744934 0.469013533039313 0.4895036242546029 2.0 0.401770042597197 0.175435765495599 -0.12167618874728 0.638270567280925 0.280093853849917 0.309031511968932 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPG21 0.265868180251277 0.275818308119417 0.670524912992125 0.167131342559481 0.486733887280151 0.782147598778917 0.18825733817574 0.66619689609621 0.292471725554303 0.354139099057035 0.480729063730042 0.175922154109519 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GRB10 0.253582167437502 0.276335219955875 0.671472325038926 0.326542622161892 0.158001353784081 0.541917271337019 0.6309070527578791 0.272796697304553 0.194804664291752 0.146125285300727 4.0 -0.0136541534842361 0.971479824154664 -0.477930398508855 0.0822087435340994 -0.491584551993091 0.0923063271732888 partial_or_other True False False True False False False 1 cross_species_direction_conflict +DENND4B 0.240064719108949 0.277083711528656 0.672049872705933 0.122746326811797 0.584603838508701 0.83427397074951 0.300874683415567 0.43489467448857 -0.366903767705744 0.234114766222505 -0.0660290842901768 0.869796887473489 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CTNNA1 -0.18661658962584 0.277202933560789 0.672049872705933 0.0672402122798959 0.691797352605502 0.886192240816414 0.0368625246234595 0.908949182532723 0.512992226009518 0.0304201997580712 0.549854750632978 0.0297616020955191 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SOCS4 -0.312053226355067 0.277923607585146 0.672279015977333 -0.44153241962003 0.114587538649719 0.492613299848511 0.571656834863143 0.114321766050705 0.127197675701291 0.676373603042264 0.698854510564434 0.0478300706388156 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PRKCI 0.224715320486106 0.278195398826006 0.672279015977333 0.239517388425004 0.246216064477984 0.611463774743042 0.162186387893753 0.601341712328105 0.0686195767499739 0.789783847223173 0.230805964643727 0.378754856732267 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ANKRD6 0.239332059058706 0.278430970682164 0.672540422892309 0.293853744656444 0.18200336884017 0.56456240235188 0.662531346031256 0.177322562541983 0.0738766618501581 3.0 0.251467661291414 0.712202692446132 -0.384444309690452 0.437578288944504 -0.132976648399038 0.837298968869281 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ANKIB1 0.183974838397127 0.278542179490932 0.672655153491598 0.184486092640612 0.27601582780399 0.6396696093258 0.389353791885399 1.0 0.320290314597797 0.326693642543117 -0.542151949482625 0.0595970546275685 -0.221861634884828 0.472296043035292 partial_or_other True False False False False False True 1 insufficient_or_context_specific +STARD3NL 0.283741055776313 0.279380454276428 0.673526682356923 0.147035660689193 0.576496435622876 0.830148577101244 0.0380017023185021 0.930449622549871 -0.0672170350898863 0.825674648135477 -0.0292153327713841 0.934929016521663 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RTN4IP1 0.367459087229812 0.279540533567323 0.673526682356923 0.0481328574351747 0.888593847686681 0.964276699808303 0.142668565880693 0.80717508122089 0.307746171827178 0.430013455989002 0.450414737707871 0.303709030038468 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CREG1 0.388848544339615 0.279766920326142 0.673526682356923 0.18932897898284 0.594361079235094 0.839992833555557 0.0512452124204234 0.940003855422996 0.640732692145576 0.167482837602569 0.691977904566 0.153896366055526 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LRRC8A -0.318490949622731 0.280038940722223 0.673526682356923 -0.48778701087237 0.092431973460849 0.472460751419842 0.0123855860568047 0.972351764894682 0.643929883188813 0.019717062778194 0.656315469245618 0.0249512845966183 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PPP1R12B 0.324948092488309 0.280041947396323 0.673526682356923 0.161137962666035 0.606913241386027 0.846931578987574 0.724524814207038 1.0 0.326486707802065 0.217300983166367 -0.339953857607875 0.141811718885432 -0.0134671498058105 0.963592920213227 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GLI3 0.311837138618572 0.280242345861185 0.673526682356923 0.56822917323278 0.0418496689393779 0.3908928278867 0.125595264626554 0.0892143230551415 2.0 0.370370506392311 0.478205676705828 -0.277263697144818 0.492553941573279 0.0931068092474936 0.861494303035836 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FN1 0.451076843665119 0.280520673952177 0.673532480875277 0.599605102679212 0.141447324041287 0.526923646040233 0.0928651819837888 0.854941973442187 -0.32967651321892 0.359146864986927 -0.236811331235131 0.540803806681949 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NOTCH2 0.255179622003675 0.280564107869811 0.673532480875277 0.388505472777331 0.095213384958614 0.475183542244264 0.0969226899125083 1.0 0.0444854195558451 0.884723195141929 0.0336671005728335 0.888419621083564 0.0781525201286787 0.747504020879527 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WBP4 0.215423233368382 0.28103735660752 0.673708845130066 0.0300643050984106 0.88047003034676 0.96227446663699 0.0449863178381502 0.908949182532723 -0.289156525239898 0.267595445422429 -0.244170207401747 0.390564341587167 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PDZD8 0.216358383527483 0.281351398776585 0.673708845130066 0.371249593437402 0.0607453468758641 0.429268745755419 0.231127118539875 0.480079703505131 0.183514528934181 0.483017212759726 0.414641647474055 0.147906971867308 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EIF4A1 -0.34826213723294 0.282224004063265 0.674013898193165 -0.308639188187041 0.345833917737769 0.691144142244059 0.292176135503082 0.215085562429668 0.0854410716716732 0.688760734653807 0.377617207174755 0.0904733013623926 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GLMP -0.405510601548424 0.282373556245202 0.674013898193165 -0.503789764685995 0.168700662973291 0.548101773166091 0.175241702745562 0.524309908686795 0.225341379348083 0.31120844669905 0.400583082093645 0.098439774611894 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GPM6B 0.496806256847458 0.282428166475086 0.674013898193165 0.448346079623858 0.330652689157224 0.679453307147133 0.390593591792805 0.562693803592855 0.119283544673753 0.813510016237876 0.509877136466557 0.372504355525603 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CEBPZ 0.218532783307237 0.282999015977486 0.674013898193165 0.168721250745612 0.409408595473333 0.734875204183517 0.362684991909325 0.332497678015757 -0.328523580287979 0.276784614512335 0.0341614116213465 0.932661736100554 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PRMT1 0.344858619966753 0.283391347503719 0.67419136040224 0.368289211051965 0.252932502851041 0.618991529980024 0.489354168536645 1.0 0.47798387780289 0.228429442424619 -0.163315172694647 0.628612699525628 0.314668705108242 0.395180938783054 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RBM26 0.159070998151841 0.28368562509591 0.67419136040224 0.140946250538535 0.342476531763337 0.689130402583821 0.0193343666848974 0.953659087606941 -0.399552381169689 0.0831296929797172 -0.380218014484791 0.114273323339895 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EMSY 0.217779607864185 0.284439790754682 0.674251304622347 0.0942495845520808 0.642710399984341 0.865003712470557 0.288454706112235 1.0 0.235583468133087 0.494795720231793 -0.171702442512561 0.54330889500387 0.0638810256205254 0.853199381712967 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ADRA2B -0.810890403589363 0.284553126016789 0.67429276217953 -0.670160999723442 0.381568013355027 0.717794232231301 0.0362469266728431 0.938060845816054 0.601741909354252 0.0665139814003498 0.637988836027095 0.0657559753076447 partial_or_other False False False False True False False 1 insufficient_or_context_specific +LMBRD2 0.262242495917485 0.286216137137456 0.675503350359926 0.293141464989818 0.23289983077044 0.602604162857471 0.5209911357528061 0.0284008494256691 2.0 -0.316963038643129 0.385997921208567 0.86102681441321 0.0124761082490763 0.544063775770081 0.0938938896800352 partial_or_other True False False False True False False 1 cross_species_direction_conflict +STK4 0.18721067913532 0.28637554425185 0.675503350359926 0.265887068561656 0.126763206209508 0.508384607335028 0.269538539665269 1.0 0.118866591842422 0.801209371511749 -0.346047280136036 0.291909653632951 -0.227180688293613 0.553618280255157 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SNX5 0.246114052901102 0.287161217261451 0.676113727797714 0.322596621959461 0.160667089208247 0.543541307772207 0.511234711910066 0.303920649131266 -0.0105935584164736 0.982326201083543 0.500641153493593 0.268097842039495 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AFAP1L1 0.417043844649614 0.28752925165195 0.676260601234414 0.53005725495335 0.176343726080802 0.558271981997333 0.003690755060717 0.996458519322138 -0.101467203896491 0.839744243734411 -0.0977764488357739 0.870298642859208 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZMYM5 0.224568544611675 0.287774890295525 0.676380757851912 0.428734784445357 0.0390843581246604 0.379484931484566 0.0585396100136543 1.0 0.0647758916421471 0.887924350717655 -0.0144721491198098 0.968344054106736 0.0503037425223373 0.897824085492523 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NUBPL 0.205991944950899 0.288938621005916 0.677462571747825 0.218618442350601 0.259275072366017 0.622885940784012 1.33393914523517 1.0 0.103178318890941 0.844700998576017 0.160799650215928 0.648955963389318 0.263977969106869 0.50364023663479 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NEPRO 0.255892965627747 0.28909588196799 0.677530371102782 0.338473025271265 0.159847133738578 0.543531735269535 0.0300479265309339 1.0 0.205910786509908 0.68765144428934 -0.39929074214601 0.289302699882569 -0.193379955636101 0.675710821649895 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PRKCH 0.406651489387693 0.291731188132582 0.678578043038158 0.0948314247227483 0.807964567445043 0.932788199072101 0.0597876651071509 0.924735721302228 -0.518355320791055 0.208992875506898 -0.458567655683905 0.323463038417611 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HVCN1 0.488036183178225 0.292136115902989 0.678578043038158 0.589037911587574 0.209214590562366 0.581592324159415 1.47709978359988 0.0673123447213966 -1.00998763745375 0.094009695239409 0.467112146146133 0.581089492942014 reversed True False False False False False True 1 insufficient_or_context_specific +MAP3K2 0.158643221198195 0.292433107904707 0.678578043038158 0.178158536296463 0.236498072907626 0.605329180588419 0.15560534415706 1.0 0.103040539870273 0.707039888495187 -0.280263319464416 0.183360531971817 -0.177222779594142 0.436225850880336 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCDC66 0.146997937338868 0.292506928083133 0.678578043038158 0.108584462004707 0.437584933214759 0.754535640189682 0.413411847328892 0.359312459730457 -0.314192192836596 0.382790827313445 0.099219654492296 0.83294338016607 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CDC16 0.160987035239055 0.292529829474531 0.678578043038158 0.269893540851612 0.0778207362495738 0.457223891665554 0.667089314122426 0.0773897446667143 -0.370172932027411 0.226852686286954 0.296916382095014 0.401510282050849 reversed True False False False False False True 1 insufficient_or_context_specific +CD38 0.484241249970939 0.292709658863346 0.678578043038158 0.583764238282383 0.20791207794728 0.580700057930969 0.394330553512565 0.0381843473011585 2.0 0.418666486460932 0.189089207703909 0.0511769740286325 0.864694784658741 0.469843460489565 0.115176904105883 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HERC3 0.313979000914074 0.292929036901936 0.678578043038158 0.376202072129463 0.209748447374293 0.581956585220706 0.504065726136973 0.186228488985398 -0.831198664585132 0.0215783929762419 -0.327132938448159 0.37593819633094 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CTTNBP2NL 0.223214379193263 0.294274883221196 0.67978920301467 0.475678067217431 0.0226652926513105 0.346028040476539 0.156393319455868 0.29579465630448 2.0 0.395444678442649 0.283615339988183 -0.0047913552203523 0.989521599252756 0.390653323222297 0.245693323860061 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CYSTM1 0.250948829924102 0.295312397185966 0.680467649203794 0.0359843202089217 0.884926923118435 0.963081098449005 0.0513274501738812 0.956914598829082 0.119438066409885 0.861961216694921 0.170765516583767 0.822373066974808 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SBF2 0.203898131433457 0.296882319958772 0.681780442725444 0.231668662707516 0.233400650193178 0.602697571243329 0.7627743436821329 1.0 0.194604651395613 0.616540463397941 0.0230055630921993 0.948463413357399 0.217610214487813 0.515757145324085 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZDHHC21 0.1464532000918 0.298896900830809 0.68384785162735 0.0334939969284825 0.807782890202103 0.932788199072101 0.688124084795767 1.0 0.035361960695688 0.951459745142974 -0.353551335444357 0.35330175061415 -0.318189374748669 0.458209861561512 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KLHL28 0.312630875349859 0.299346016738861 0.684237983271032 0.367248171812458 0.225265025715908 0.597424803192304 0.938818128333559 0.0308179391024494 -0.301847959582943 0.355006609806306 0.636970168750616 0.111218950308778 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HIPK1 -0.230613605164843 0.301164327699812 0.685730686665997 -0.366234042737525 0.0977055111947804 0.478125555523304 0.07204064533005 0.835861990118011 0.46133347448624 0.0657719812495692 0.53337411981629 0.0501053549929725 partial_or_other False False False False True False False 1 insufficient_or_context_specific +VPS54 0.160228105696094 0.301693859606951 0.685730686665997 0.308675151107524 0.0389727820025641 0.379484931484566 0.517967713936717 1.0 0.0845790523137202 0.849197910818327 0.021065944867352 0.952558027623544 0.105644997181072 0.770818562403608 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PLA2G15 -0.423885875252837 0.302061802601194 0.685842690723312 -0.682145797616153 0.0865601447058766 0.467677448123587 0.274799859084794 1.0 0.488759846817093 0.125027258460571 0.0706540729432639 0.800573996950688 0.559413919760356 0.0673956146985598 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SRBD1 0.199202112962775 0.30231159550974 0.686262271638753 0.164523812522146 0.394908111413884 0.726080478554543 0.045757608140315 0.934161656657953 -0.200292849741724 0.581902097632955 -0.154535241601409 0.717485868292469 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NDUFS8 0.321434693019164 0.303427901609393 0.687761224815794 0.103782539102725 0.732115147040716 0.904431845923655 0.311356885508479 0.0178216701630811 2.0 -0.0229705320910787 0.962513237604274 0.714118675101553 0.0420192962565403 0.691148143010475 0.0582993712727717 partial_or_other True False False False True False False 1 cross_species_direction_conflict +CRACR2A 0.26470570120924 0.304205140049174 0.688684972588625 0.12393886226763 0.635009821263774 0.861847932958146 0.50575365317725 0.403880964912857 -0.4215020241424 0.358442439635704 0.0842516290348493 0.898053462711266 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PRKRA 0.224916169357449 0.304940685456355 0.689857243850053 0.449129509686108 0.0422021141045194 0.3908928278867 0.0460772366362023 1.0 0.495007495215828 0.145908829314412 -0.0102407792971714 0.974195173369082 0.484766715918656 0.126859312546668 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACOX1 -0.285355338502606 0.305848735616199 0.69036356027618 -0.370404953773207 0.179278144532162 0.562350982890208 -0.585339245240227 0.206530424500391 1.53437258635814 0.0044756482472826 0.949033341117911 0.0396757426500509 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MSMO1 -0.390209877282239 0.305862435070716 0.69036356027618 -0.698009848601159 0.0529514215730707 0.416277817549129 0.594090057669176 0.170952812656946 0.0916728248917981 0.816305038853356 0.685762882560974 0.094138017421303 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RAD51B 0.307252262774812 0.306425298802574 0.691142556025973 0.436255126839168 0.134855880100932 0.521613530841394 0.5514795346662061 0.305642371078823 0.120980569768532 3.0 2.52493365459823 0.0035177853838678 -2.197504790683 0.0025837992993737 0.327428863915221 0.733294501887334 reversed True False False False False False True 1 insufficient_or_context_specific +SLC30A7 0.226063981037277 0.306603445211273 0.691211779253462 0.377327492599785 0.0837964587184169 0.464779732481256 0.2837109666603 0.379442480050209 -0.240079603174985 0.364552485275278 0.0436313634853147 0.898603818783296 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TAF15 0.170907293333654 0.30686588521946 0.6912288995205 0.0124044929694791 0.942186978281578 0.984366565940656 0.0913482668844384 1.0 0.16142901036444 0.60729398970626 -0.881110674689775 0.0056071501816413 -0.719681664325336 0.0217271401484915 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TYW5 0.294432097645135 0.307306409585407 0.691504917391886 0.304368996426517 0.292661541535512 0.651509781962399 0.592520555653964 0.13749999428979 -0.612170744584106 0.0719114318057083 -0.0196501889301428 0.96614167626696 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IPO8 0.179607459267449 0.307971356153954 0.692116129900691 0.297808173359036 0.0754792225282577 0.453930920096201 0.0341931504006784 1.0 0.0992455886902886 0.775144300441186 0.343938942357009 0.17099468290883 0.443184531047298 0.106723602699241 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CASTOR2 -0.353931099813465 0.308966741319327 0.692554584050891 -0.361096494323514 0.298689552494286 0.656810536247326 0.259333594923543 0.612872257609593 0.491407002223046 0.168406099444238 0.750740597146589 0.081092163729848 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TNPO1 0.186019957461339 0.309067764281054 0.692554584050891 0.236523164351365 0.193656363967983 0.570885363891703 0.7940766372787471 1.0 0.160039728850661 0.5728361407637 0.0587211629182791 0.810342185379615 0.21876089176894 0.365031594858743 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SCFD1 0.222631391300667 0.309148459736575 0.692554584050891 0.414422415125431 0.0490079606722464 0.404177169779245 0.108877955818519 0.0897328858235695 2.0 0.0583931880765849 0.868066792119258 -0.118292282038102 0.639367902883543 -0.0598990939615171 0.838553456940443 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMPO 0.244444332325615 0.309264092818381 0.692554584050891 0.0443594258767574 0.854379126995327 0.95526155065304 0.0350813849957946 1.0 0.41680022481166 0.244503079253837 -0.416187441651681 0.168076113375614 0.0006127831599796 0.999089144569744 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPP1R13L 0.335721606899341 0.309374990850076 0.692554584050891 0.300220632923599 0.361842363204627 0.703533322359016 0.5170186443139461 0.0602245825867887 2.0 0.052057537629799 0.941370940333227 -0.770098474467216 0.11083868726255 -0.718040936837417 0.181422510585686 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCNG1 0.268349237454158 0.309514056109647 0.692554584050891 0.231453711915063 0.385316356204287 0.719875101655461 0.9694112902763 0.0038119192011812 -0.571756808474231 0.0308307222802141 0.397654481802069 0.138684072391377 reversed True False False False False False True 1 insufficient_or_context_specific +COL16A1 0.444230655182136 0.309574953297443 0.692554584050891 0.615032108638281 0.161087805507328 0.543541307772207 0.787688369188889 0.8569837001355121 0.11189908808496 3.0 0.386097884010166 0.329168493929556 -0.670970757206792 0.0619331207919431 -0.284872873196626 0.435505830284143 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FBXO32 0.494926215424625 0.311036269605006 0.693321067905565 0.283899553847881 0.560573257132527 0.822697818631225 0.276063738281228 0.648410825232897 0.156022373423183 0.718192135559082 0.432086111704411 0.383093936037293 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DENND6A 0.187132405286566 0.311454267878989 0.69344878959645 0.0965559264483411 0.604021667818083 0.84556626476045 0.192432745183242 0.640370349668519 0.245118402011282 0.422595227101654 0.437551147194524 0.19772772239564 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MFHAS1 0.250117050827085 0.31207104645383 0.693580991012765 0.41559579614184 0.0804932536846428 0.460444042266761 0.575351440289531 1.0 0.0383596068227315 0.937434964750653 -0.137609735593348 0.691303649087595 -0.0992501287706166 0.79847326307896 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NKD2 -0.452960544330836 0.312262659702667 0.693580991012765 -0.419208908917357 0.352524198000197 0.696603122306959 4.30439241294707 7.41344537805846e-05 -2.2316924141114 0.0008632955010727 2.07269999883566 0.016697514441953 reversed False False False False True False False 1 insufficient_or_context_specific +ARMCX4 0.175722778233044 0.31230809659157 0.693580991012765 0.0246447540508803 0.886799475459196 0.963622568156774 1.52939303203497 0.0018195703596251 -1.3201674204479 0.0030507204347802 0.209225611587068 0.596042453348345 reversed True False False False False False True 1 insufficient_or_context_specific +THOC2 0.114977437905025 0.314488058716239 0.69518456354526 0.0847752598404229 0.460932759437459 0.768806812434888 0.143990095415468 0.693030631291966 -0.393503674354782 0.167107147567351 -0.249513578939315 0.411580036046107 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EBF4 0.262320657409286 0.314663283519601 0.69518456354526 0.135214349168729 0.605665970595706 0.846820726734085 1.25252860356422 0.0254489527712211 -1.38036795854946 0.0099090039390119 -0.127839354985242 0.82869638988022 reversed True False False False False False True 1 insufficient_or_context_specific +MGAT4B -0.329699863109981 0.31476325766471 0.69518456354526 -0.175532554832002 0.606922175281302 0.846931578987574 0.398111892554478 0.071522633574583 0.0118604085824979 0.956271288848589 0.409972301136976 0.0549533665136731 partial_or_other False False False False True False False 1 insufficient_or_context_specific +EIF4G2 -0.197796370148546 0.314806076730613 0.69518456354526 -0.319893864634049 0.103386773656865 0.47952541118609 0.344348373007585 0.195091343261696 0.489563712722566 0.0466779229560313 0.83391208573015 0.0074466605023391 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RNF40 0.266912406961116 0.315031643134718 0.695255871282682 0.0522388263776435 0.842770052847734 0.950469545398617 0.0133993370229473 0.967418566772765 -0.436826570159346 0.0630609619552262 -0.423427233136398 0.0858080600377512 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TCEAL9 0.345622946117687 0.316663605093082 0.69698002878843 0.051670815736642 0.881536049676029 0.962618478946739 0.664903868365136 1.0 0.491157964292742 0.121579692546491 -0.400049609970405 0.150083290251539 0.0911083543223369 0.779807062401457 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAP3K3 0.205347806570662 0.31675777188646 0.69698002878843 0.0297398485502383 0.884337808064698 0.963081098449005 0.291002091707043 0.35897333386557 2.0 0.267731699379606 0.267419018107283 -0.123963943205211 0.558036321027118 0.143767756174396 0.529044448942367 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCDC25 0.205528099813598 0.317866387012208 0.69725537777819 0.0665895553697338 0.736802964827403 0.906049555039219 -0.433236786048663 0.140300758498381 0.89006451825573 0.0049775100403267 0.456827732207067 0.0904733013623926 partial_or_other True False False False True False False 1 cross_species_direction_conflict +WDR3 0.314738561819152 0.318026548711469 0.69725537777819 0.272148768523495 0.390687861647914 0.722269732670054 0.265570957679067 0.579090236593583 -0.196878184846915 0.598616155839273 0.0686927728321516 0.885914643457236 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WDYHV1 0.271910981467357 0.31824248864545 0.69738567769171 0.108678217257974 0.687374146733323 0.884451344908836 0.485394373446326 0.454828367038178 2.0 0.156679785508581 0.764540655715377 -0.434526222292452 0.244331783933167 -0.277846436783871 0.524894194864293 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CLASP2 0.198331613664551 0.318880166116565 0.697624698271589 0.394258897905047 0.0380498160994375 0.379484931484566 1.12363727856778 0.0868577680590229 0.118161621046474 3.0 0.0078164567138242 0.989165574768777 0.0048162117695084 0.991552677629496 0.0126326684833327 0.979881713598889 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PNRC2 0.258302113431373 0.319343163340951 0.697992602227829 0.168593221280921 0.520313371954667 0.801118945922776 0.317490800374953 1.0 0.223634694273203 0.458336604348565 -0.0856769673408401 0.747140719469195 0.137957726932363 0.622255824339323 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DIS3L -0.203769479299221 0.320357805958205 0.698830106468333 -0.272047666410562 0.176511751010499 0.558469004245985 0.299797103902484 0.43818386322322 0.332371675166253 0.262553310232916 0.632168779068737 0.0712156106788186 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SLX4IP 0.225377678113605 0.320796020984919 0.699310209095386 0.377087288709474 0.0869390209001928 0.468259042610703 0.644620852150319 0.22278745817767 -0.141843126269142 0.741168213810107 0.502777725881177 0.308657601760708 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DDX1 0.189683430295536 0.320906479547334 0.699310209095386 0.245207963158806 0.19753157390676 0.572478275406963 0.31699952150968 0.330669677459799 -0.128096907518715 0.655430297858002 0.188902613990965 0.538941807163739 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ERI1 0.212832384647023 0.321994043520531 0.699787065268571 0.397673517394472 0.0611305945821428 0.429419040318206 0.369029799179894 0.382191033435019 -0.462149338768362 0.173996397570965 -0.0931195395884678 0.833562791283526 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PREX1 0.481883554749433 0.322054659769464 0.699787065268571 0.328049179960163 0.495518718660273 0.787904613195055 0.723940440559708 0.111983612852235 -0.141239911045652 0.699628346598099 0.582700529514056 0.171513141985865 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DDOST 0.411908449244389 0.323824260059691 0.70145601563391 0.239483465374495 0.553041657798985 0.819071644755648 0.626735767129473 0.333946533881818 2.0 0.0052477750331405 0.990418560275096 0.359420770209259 0.205317715700899 0.364668545242399 0.220670709896878 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GK5 0.233573363368728 0.323968422817214 0.70145601563391 0.182418101572666 0.440045604651302 0.756769095948255 0.279804408818582 0.514073540290151 -0.556001612012093 0.106125942583582 -0.276197203193511 0.478387643131256 partial_or_other True False False False False False True 1 insufficient_or_context_specific +JAG1 0.325942253621387 0.32453913368 0.701877699823414 0.503358391209597 0.118823154178955 0.499416744355655 0.3642726582575589 0.0901403132857535 2.0 0.331002936057288 0.34475600395944 -0.371141951185849 0.212476410475562 -0.0401390151285614 0.915794372313801 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SENP6 0.159277754162116 0.324775267765648 0.701912732303227 0.251275291834916 0.109369298411789 0.485176912870447 0.271360014252571 0.25462534584094 -0.201441577970485 0.323371690278407 0.069918436282086 0.773264764578652 partial_or_other True False False False False False True 1 insufficient_or_context_specific +H2AFJ 0.235236262867971 0.325187706090413 0.702354528183064 0.198123731835717 0.408874174985464 0.734801770489731 0.273731311238874 1.0 0.273331221358061 0.396133867777243 -0.782038682686007 0.0132242980310499 -0.508707461327946 0.0954444695151388 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CUL1 0.145094542682352 0.325299644138585 0.702354528183064 0.0994800626823866 0.500800207773331 0.790819493321426 0.134318750449556 0.584615418994467 -0.272525472950869 0.170665765605602 -0.138206722501313 0.520401216670742 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HIBCH 0.179214176531365 0.326377594736543 0.703454275022371 0.197186586695335 0.278477514073313 0.641950971352435 0.0593530935120767 1.0 -0.495950419628407 0.131068440315188 1.21265052298044 0.0019014954372257 0.716700103352029 0.0262451999009054 partial_or_other True False False False True False False 1 cross_species_direction_conflict +GSTCD 0.216439980718976 0.326764769099619 0.703567204687985 0.111187268575027 0.614898309210092 0.851310824631544 0.208042428151452 0.730626228144607 -0.0322983005786985 0.948193148017817 0.175744127572754 0.740597325653249 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GTF2H2 0.393552760339241 0.326991923593114 0.703712920129988 0.551666798697651 0.169579151175119 0.549544713967741 0.279557874251904 0.456251692377991 -0.895209600652592 0.0136531712302267 -0.615651726400689 0.0828769757484442 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATP8B2 0.244142498405694 0.327126877271019 0.703852775673002 0.0576452776116477 0.817890818061473 0.936785773171298 0.601322805873136 1.0 0.558382990780139 0.139868835854374 -0.848242434308189 0.0203824500143985 -0.289859443528049 0.421375030668737 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM39A 0.217036581512777 0.328216088296025 0.704473563779108 0.378489531551067 0.0890317058839671 0.470236852611986 0.49815789440921 0.049577968398733 2.0 0.312080630009279 0.235582460237373 -0.654008058868764 0.0132242980310499 -0.341927428859485 0.169010941645089 partial_or_other True False False False False False True 1 insufficient_or_context_specific +XPR1 0.172638696845516 0.329397559676306 0.705454272104554 0.282722777860035 0.108700607390768 0.485176912870447 0.141361442265612 0.65865136019459 -0.0138493695979389 0.961004759139789 0.127512072667673 0.650746114922428 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MTREX 0.156901494076664 0.329837072426447 0.705800529120071 0.0289781843152394 0.854264454560997 0.95526155065304 0.0821337870252801 1.0 0.255663691957461 0.372867518414602 -0.0468837068703001 0.861948088871369 0.208779985087161 0.421375030668737 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GRK3 0.302378161978332 0.330848484320959 0.706568009779684 0.273299613348032 0.381601674284074 0.717794232231301 0.328906786279707 0.298601093714724 -0.986318209702917 0.0049487393989358 -0.65741142342321 0.0413214987200134 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KANSL1 0.249388161358417 0.331045822351203 0.706568009779684 0.422638379710066 0.103635157871422 0.479908794539589 0.0582007362919186 1.0 0.150213883691284 0.604968023577395 -0.291619295051665 0.212028537584875 -0.141405411360382 0.581128083822891 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPICE1 0.193426195215102 0.331299666609655 0.706568009779684 0.152197303245963 0.445225627395623 0.760927015161427 0.24203896467889 0.607821568864938 -0.382281549948753 0.27599909330465 -0.140242585269863 0.756327389249084 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HPS3 0.338139733627437 0.331653566914241 0.706679790006167 0.360595785754977 0.301074544984056 0.658632920234719 0.8539768054100001 1.0 0.101174099994834 0.852146947349664 -0.393127734808609 0.281061804546386 -0.291953634813775 0.482603395722676 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC38A9 0.180809711155636 0.332153454100673 0.707316693907806 0.247420871180933 0.180806913421895 0.563603217043398 0.380972752463765 0.222344496537222 -0.500357320725336 0.067780045754583 -0.119384568261571 0.709113721153133 partial_or_other True False False False False False True 1 insufficient_or_context_specific +COMMD2 0.367352917726316 0.332490056209102 0.707462719358263 0.694363899529194 0.0699888173361972 0.441950917126537 0.0155659388337737 1.0 0.123556663895248 0.797189358910681 -0.0764163296830764 0.836543207084056 0.047140334212172 0.91512457989464 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CAMK2D 0.26899344718874 0.333803558833428 0.70897163028834 0.361336896459601 0.187471922122501 0.56929178900529 0.432947147400204 0.361984834198274 0.0943345853035438 3.0 0.104861201462389 0.764723842807102 -0.669881628607342 0.0228500187717675 -0.565020427144953 0.0552956444108226 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NONO -0.194261440350179 0.334391937496719 0.709266578146451 -0.18955526413958 0.345662394740363 0.691144142244059 0.819604287008425 1.0 0.367205573538032 0.244172874087586 0.295140108908113 0.273065728075551 0.662345682446144 0.035042795965661 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TINAGL1 -0.328741050246118 0.335122164732631 0.709266578146451 0.0230907943912614 0.949700928987848 0.986917609553614 0.59409687896636 0.7340936149720709 2.0 0.263472278910993 0.270485391097982 0.254160867468442 0.211421354651901 0.517633146379435 0.0310091224997019 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MAMLD1 -0.338274285927068 0.335154727324114 0.709266578146451 -0.21813097237725 0.535348289292191 0.811049969629352 0.0760931606976529 1.0 -0.0408358957997883 0.954530635502806 1.16681798014435 0.0164838658272957 1.12598208434456 0.031164384562845 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DNM1 0.366332084544299 0.33515686921695 0.709266578146451 0.166121162347398 0.670563445197309 0.876647951262157 0.0380265979448025 1.0 1.57126668213575 0.0048881458792429 -1.09324602075219 0.0130050939274078 0.478020661383561 0.315035427413545 reversed True False False False False False True 1 insufficient_or_context_specific +TIMM17A -0.291579673575033 0.335213063804064 0.709266578146451 -0.370020752902787 0.221727181537815 0.592957341103408 0.344174557836382 1.0 0.261435756638431 0.544056365712869 0.364734466329107 0.267716262329914 0.626170222967538 0.0944887873462835 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SKIL 0.256941382227301 0.335249968432595 0.709266578146451 0.373917253773724 0.157285370793915 0.540743121915691 0.189876641636318 0.182753313952353 0.0925771047388125 3.0 0.0858505270422918 0.767432678623387 -0.451928765745617 0.0492887940202823 -0.366078238703325 0.117934511079421 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TOB1 0.443542709999567 0.335308166538726 0.709266578146451 0.66062402642111 0.149877125320719 0.533583468169136 0.463282320026245 1.0 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partial_or_other False False False False True False False 1 insufficient_or_context_specific +MRRF 0.142013355850791 0.363167676745406 0.726173502640625 0.0597942638876862 0.709959143063172 0.894500642532718 0.127871664034642 0.787647587732967 0.420327046829562 0.198844343739126 0.548198710864204 0.135275628399412 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AGBL3 0.204204383124348 0.363224310233485 0.726173502640625 0.380601125882441 0.0683998764285882 0.438244764077482 0.0226411772639403 0.977528461326785 -0.17195356043419 0.748189701345449 -0.14931238317025 0.82071832347107 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PLEKHA2 0.25378179946922 0.365079672614218 0.728194059214707 0.177414944426433 0.527060277159243 0.804819865166353 0.17203214273429 0.5389507333812971 2.0 0.107153211314956 0.784947378045873 0.212638517255972 0.456427383352826 0.319791728570928 0.294325762660054 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CRLF3 0.154938632327553 0.366363685586583 0.729053353040119 0.241693851918873 0.164915385413138 0.545094551255265 0.413073207960221 1.0 0.138128257590348 0.651469634901764 0.0882159650188909 0.715513090409937 0.226344222609239 0.371501323957656 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPRED2 -0.183782880674966 0.366440428051321 0.729053353040119 -0.270498717618562 0.187675656157808 0.56929178900529 0.8298501741967141 0.543375448635365 2.0 0.0306514681723399 0.941363125049339 0.513967134326068 0.0682258246749205 0.544618602498408 0.0735447227021349 partial_or_other False False False False True False False 1 insufficient_or_context_specific +LPP 0.226463166226263 0.36647401804973 0.729053353040119 0.0334434225742497 0.89239783419688 0.965368150296491 0.243354521793503 1.47023590305452 2.0 0.481684095873711 0.116187300331522 -0.265155727842137 0.321777829400336 0.216528368031574 0.448000726926336 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZC3H8 0.220692047459356 0.366736347603341 0.729053353040119 0.384205285351667 0.106684393674017 0.483261130274234 0.026585697680814 1.0 0.783207643001239 0.203216330643772 -0.916234153171302 0.0731128445739084 -0.133026510170063 0.850065038552151 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZFPM2 0.265007598723664 0.366857335879459 0.729156579859813 0.30499124430877 0.298296284165335 0.656537871214844 0.8256914318042192 1.0 0.280302696771379 0.45348189818789 -0.0748683478079611 0.821195824199984 0.205434348963418 0.548189743260977 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UBE2N 0.23574015187547 0.367168688041014 0.729567043961616 0.547206951686179 0.0258940066510446 0.353215661785179 0.0610916605954791 1.0 0.491626917542731 0.308572948678479 -0.193301941583112 0.624748038593797 0.298324975959619 0.511709192417516 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SEC24D 0.236736402679585 0.367478456126906 0.729567043961616 0.451426115885959 0.0727388099725703 0.449108979935905 0.320636109787547 0.0868170148193622 2.0 0.0533363665307987 0.900364871566824 0.114015319818923 0.704054989545199 0.167351686349721 0.59996718233085 partial_or_other True False False False False False True 1 insufficient_or_context_specific +URM1 0.192629683100711 0.368200932348995 0.730221691806275 0.201484133908181 0.345713751443249 0.691144142244059 0.241492426373188 0.388504738574039 -0.158712301406219 0.497342436400117 0.0827801249669684 0.766813623813635 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCDC18 0.211895407527042 0.369213624919357 0.731653877081275 0.271029199575506 0.252849580437077 0.618991529980024 0.0459440209379158 1.0 2.54754547540691 0.0103019369675089 -4.04789652852478 0.0011147174699868 -1.50035105311787 0.300466293054225 reversed True False False False False False True 1 insufficient_or_context_specific +RNASEH2B 0.201771550666773 0.36930939588825 0.731653877081275 0.166503989783722 0.458730677964696 0.768201799558117 0.30747985208203 0.548452752179335 -0.413970556938528 0.282693919369635 -0.106490704856498 0.836895377110856 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CC2D2A 0.212198291268067 0.369607030792289 0.731671383469312 0.207486600394759 0.380648982713572 0.716891180786638 1.06243263309513 0.483238076816687 2.0 0.385383468612088 0.219932855846463 -0.480040227455062 0.0799696695885266 -0.0946567588429742 0.772549972484626 partial_or_other True False False False False False True 1 insufficient_or_context_specific +THOC7 0.263056045391399 0.369786168609282 0.731671383469312 0.353404468476928 0.231247747397222 0.601518427890281 0.220973275087901 0.383134393962592 0.0269142560008343 0.913901333254574 0.247887531088736 0.275352368955848 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PGRMC1 -0.3086609015361 0.370215444856243 0.732109883272563 -0.293672019491356 0.39494981893718 0.726080478554543 -0.227379834171137 0.664025509525899 1.32233572611466 0.0088109125189793 1.09495589194353 0.0248774099173533 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NUDCD1 0.218243330765428 0.371047999226099 0.732516662081887 0.231536770141114 0.34246240031799 0.689130402583821 0.202522691559045 0.704550364501967 0.200805346879238 0.59396016460612 0.403328038438283 0.348075108285352 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TUBA1B 0.371804497445119 0.371206418793904 0.732516662081887 0.329601922933635 0.429870812136117 0.748569360800449 0.687053071731284 0.158992152863068 0.0240484432571681 0.959654857099631 0.711101514988452 0.119233745418908 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PIH1D1 0.227639891521577 0.371425918208664 0.732692758319164 0.350611906191851 0.162534378334998 0.544298760692042 0.634407046847986 0.0121715524712853 2.0 0.0661617971460874 0.8761579807827 0.150217921926193 0.608652883867055 0.21637971907228 0.493047370169179 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MLLT10 0.151021724676812 0.371587636929382 0.732764712495408 0.277737103807463 0.0951191957502324 0.475178240428531 0.0711698465650635 1.0 0.0592129222116146 0.862981521576469 -0.139354965025366 0.564856283878203 -0.080142042813751 0.776650749189909 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SH3PXD2A -0.344646278942884 0.371958467891822 0.733222088125813 -0.39039272646781 0.30821982761379 0.662330926800867 0.3920900977428711 0.68524682490603 0.219644683979082 0.114610643074346 4.0 0.144199653261986 0.590441549396092 -0.330004848827754 0.128902360129487 -0.185805195565769 0.417665273110085 partial_or_other False False False True False False False 1 insufficient_or_context_specific +TNRC6C 0.147369035037165 0.372455715034781 0.733791274367834 0.131535526107224 0.424362011249371 0.745581710374036 0.372721498276598 0.142257880564804 2.0 0.0359815870322305 0.908381786429681 -0.0103586168451802 0.966580777113563 0.0256229701870503 0.922437762688832 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SCCPDH 0.263896482909479 0.372742137463556 0.733807847723331 0.231419384156278 0.433170884896824 0.751350456611089 0.606591318191836 0.217302286149363 -0.38060261997916 0.329594387373366 0.225988698212676 0.647950903985246 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FBXW4 0.168046282627388 0.373196550361597 0.734291684442367 0.12243490167265 0.51676082467592 0.799994250282751 0.880734201799675 0.130172890183871 -0.0887032683099761 0.857730745639101 0.792030933489699 0.146406527335482 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EIF3K -0.226323114613506 0.373357840799229 0.734381193835654 -0.2000131138073 0.431599704719365 0.750342447295744 0.303136188784131 1.0 0.145511526164521 0.633475319510166 0.387280019323844 0.109014969261461 0.532791545488364 0.0480280561830428 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PANX1 0.274156419981556 0.373902122490306 0.734858266800567 0.320736458723475 0.297735734058558 0.655714201124375 0.892913093703374 0.060725149951687 -0.459159213539792 0.204348735592352 0.433753880163582 0.332646961763079 reversed True False False False False False True 1 insufficient_or_context_specific +SMPDL3A 0.360145005933227 0.373980249263872 0.734875018002598 -0.407382146384384 0.27614739741442 0.6396696093258 0.156974013936755 0.754286459522185 0.81868516672988 0.0274208226545536 0.975659180666634 0.023257696200555 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PCM1 0.130027966132398 0.374257722880405 0.735203486361493 0.193647307288287 0.183794512144688 0.565716727964854 0.0202230399002199 0.950285004327358 -0.242628738832783 0.267315845026764 -0.222405698932563 0.336907170095018 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SCAND1 0.291122622808944 0.374391376920934 0.735203486361493 0.392703539085791 0.231642724983497 0.601518427890281 0.0224588523973722 0.948375449422629 0.0136889382801954 0.958509739697101 0.0361477906775676 0.898633258206592 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZDHHC14 0.170456368795433 0.374843755169911 0.735203486361493 0.277262483138526 0.141653649173693 0.526983519371334 0.480507386401442 1.0 1.1621510807484 0.0169051077070871 -1.23132699450892 0.0081642758795006 -0.0691759137605194 0.893412772228668 reversed True False False False False False True 1 insufficient_or_context_specific +N4BP1 0.166053018043463 0.375117343490043 0.735412237011466 0.219868524785542 0.237370272546602 0.605329180588419 0.479125485001 1.0 0.377040203206196 0.190373025256741 -0.170187547914736 0.493670187648597 0.20685265529146 0.441064885541466 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BIRC2 0.187843399916007 0.376492011825398 0.736420409495083 0.0550278299020077 0.79854218027841 0.92925379048471 0.120487988772335 0.708091028975785 -0.044720218070245 0.870827370971172 0.0757677707020905 0.796176040364719 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TSFM 0.284241582970235 0.377480789282053 0.736881825751929 0.188199901033831 0.558281338101776 0.821510016401191 0.365504311640411 1.0 0.165480176734675 0.66619689609621 -0.300849833005488 0.298978659534816 -0.135369656270814 0.694471253679652 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UGCG 0.359500138091061 0.377714920288929 0.73713754684113 0.447430300938412 0.267102952747154 0.630183905051274 0.40450205244657 1.0 0.379024206468685 0.322611567357763 0.0066508558089967 0.98587989384826 0.385675062277682 0.267323485792788 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MARK1 0.160230220756565 0.378306878443456 0.737487048740799 0.34708383200655 0.0541411365014878 0.419081294430039 1.58314170357064 0.0481588286512885 0.0661997280863779 3.0 0.955448839425108 0.0166454353479858 -1.20734701861112 0.0043706171450889 -0.251898179186011 0.476780027326437 reversed True False False False False False True 1 insufficient_or_context_specific +NBDY 0.192197013489692 0.379845822126121 0.738946890008695 0.124231979824438 0.567660548112632 0.824849995454606 0.36235344009243 0.404350397279178 -1.03793629865206 0.0138796090199444 -0.67558285855963 0.110845041418459 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZBTB25 0.22766667823632 0.3801540329923 0.739057534854654 0.0750218069516694 0.768246259813497 0.919690570309936 0.427521909318086 0.415741600019983 -0.414431319837426 0.311614865348205 0.0130905894806596 0.983365274551655 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RPGR 0.198235997868961 0.380168731937453 0.739057534854654 0.198430430194914 0.379829693248458 0.716424065042321 0.219636239594289 0.728713835837385 -0.446907761435014 0.323491532283294 -0.227271521840725 0.691445961691042 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ABI1 0.146545696032808 0.380639644469108 0.73929237790744 0.265697787123398 0.103930244049735 0.480082620019266 0.306760813005848 0.433680913008626 -0.563995659607291 0.0955993518709198 -0.257234846601442 0.466566447534186 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IFT57 0.148773526010893 0.381473826783617 0.739959702954516 0.0288939391443027 0.869496697404195 0.958502690861149 0.0394527930531822 0.948978490920634 0.459637679510863 0.212720479508253 0.499090472564045 0.233677887854942 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SMCHD1 0.114355069107536 0.382673563799507 0.740234345710621 0.185010915572546 0.146666291039319 0.532796338690088 0.0310796994748782 0.939429039629591 0.0887977205018276 0.757686022854965 0.119877419976706 0.70063982580341 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SENP5 -0.126750921402157 0.383376828305288 0.740600133342206 -0.0213190688175065 0.885224121538331 0.963081098449005 0.352520879048179 0.270185233851751 0.173150100790906 0.5162846527107 0.525670979839085 0.081092163729848 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PROSER1 0.239492905353172 0.385069812964614 0.742433726311247 0.163570836251868 0.558149707993743 0.821430808056585 -0.045811866573428 0.938612474455784 1.06018254072717 0.0108050520501676 1.01437067415374 0.0234750098498919 partial_or_other True False False False True False False 1 cross_species_direction_conflict +TRMT10C 0.357468862542441 0.38539145893365 0.742918207672353 0.521045389308015 0.212677640656245 0.585220331857814 0.109816017414585 0.798645769177701 0.174411030646334 0.562558881045646 0.28422704806092 0.388495737965087 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NUP133 0.187358973617683 0.385569571792355 0.743125874221191 0.183729204779411 0.394467033762721 0.726080478554543 0.6814127388876711 1.0 0.36348240392376 0.260992763164454 -0.0858656134752284 0.761912762997075 0.277616790448531 0.351009863943006 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PGGT1B 0.197240051461521 0.385965652030818 0.743306969972875 0.36403632482482 0.111567512325387 0.489987435578799 0.109504281120625 0.753360560689306 -0.271991935911516 0.287021725671625 -0.162487654790892 0.574210868033683 partial_or_other True False False False False False True 1 insufficient_or_context_specific +POLA1 0.151315646388023 0.386142428794658 0.743306969972875 0.162433753569169 0.351141134655967 0.695703312194568 0.0243555033253125 0.95762493377024 -0.398647684619034 0.19735172752457 -0.374292181293722 0.268694967856295 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SMC6 0.19247924219393 0.38652724246165 0.743586634783422 0.156713955647298 0.48288461153006 0.780666906162311 0.0479023334527581 1.0 0.583376337854222 0.0405992062992353 -0.314416094783446 0.186054684205675 0.268960243070776 0.295630617414883 reversed True False False False False False True 1 insufficient_or_context_specific +CPEB4 0.296436209247451 0.386621725976816 0.743586634783422 0.256126892840223 0.457364379170224 0.76776776876263 0.258289136860865 1.0 0.0788442419603141 0.796635397443923 0.0479044444408302 0.846977529705576 0.126748686401144 0.608119365637099 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACTR1B 0.196209036504988 0.38684680526871 0.743591294181738 0.0647335452318479 0.782400816910307 0.924647355053618 0.213549165448066 0.439274743255759 -0.121606821851502 0.607673908506329 0.0919423435965637 0.730124900744758 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FBXL5 0.157801929806978 0.386867491848862 0.743591294181738 0.0388599888721917 0.833662251030135 0.945617323418153 0.531073170127566 0.104428503696097 -0.247486864452705 0.367719409150488 0.28358630567486 0.351009863943006 partial_or_other True False False False False False True 1 insufficient_or_context_specific +APTX 0.180648927537826 0.387996781805245 0.74467733544806 0.189248950599991 0.364486476202785 0.705850610221272 0.0422765286366976 1.0 0.0350641994368351 0.938047378605598 -0.172805242802643 0.564649294202046 -0.137741043365808 0.693949154361178 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RAC1 -0.121302411955188 0.390162452890053 0.745715998843805 -0.10472073240416 0.458722990665292 0.768201799558117 -0.0187505330399685 0.962480622160178 0.658875377613734 0.0214824717836886 0.640124844573765 0.0346143298655784 partial_or_other False False False False True False False 1 insufficient_or_context_specific +FBP1 -0.467459151117158 0.390262789490032 0.745767047882111 -0.513916300733289 0.34312555102152 0.689926781453268 1.49723442423972 1.0 -0.58316507409208 0.241342963972745 1.39841654454231 0.0088844953388967 0.815251470450229 0.0838644803426403 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SDCCAG8 0.185244965322056 0.391601867158404 0.745767047882111 0.199812099478849 0.353571398172822 0.697398977158885 0.364364373054671 1.0 0.106503328244448 0.718513095972525 -0.33787160593072 0.136640748242516 -0.231368277686271 0.338071931521872 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NDUFA10 -0.174818328540271 0.391711637814153 0.745841563939014 -0.24301448119469 0.226008224875697 0.598493814456385 -0.029011963801468 0.949950680556985 1.25285892331945 0.0029994447458525 1.22384695951799 0.0049979365531362 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NPR3 -0.629254838091479 0.392073126081333 0.745991721961924 -0.0438132106514228 0.951957656345331 0.986917609553614 0.420730529147023 1.0 1.67549924720975 4.06243374375236e-05 -0.932068415389489 0.0014550940008916 0.743430831820256 0.0066221187267941 reversed False False False False True False False 1 insufficient_or_context_specific +SNRPB -0.314789222044216 0.39231992413173 0.74624543069242 -0.0664531052701874 0.861629955614792 0.957822965712685 0.399077733276235 0.3474545876283 0.747077657198811 0.0322898907918484 1.14615539047505 0.0109886815635963 partial_or_other False False False False True False False 1 insufficient_or_context_specific +POLR3C 0.233906256911852 0.393866610813236 0.746444745461522 0.253470640966593 0.356613011354932 0.700023673094392 0.0246419921107148 0.954530635502806 -0.257820264684518 0.361080493687149 -0.233178272573803 0.456375665965167 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KIF20B 0.285519636466032 0.394134997331833 0.746535081414728 0.08357009548057 0.798492025959353 0.92925379048471 3.20548478699258 0.0103461786531277 -3.1025077200472 0.0043706171450889 0.102977066945378 0.954635233675125 reversed True False False False False False True 1 insufficient_or_context_specific +NPAT 0.181139685165095 0.395063716359149 0.747238036065908 0.145254047149399 0.492812564384391 0.786325382313799 0.773624098598138 0.0645718561907952 -0.145618111078099 0.662780700151629 0.628005987520039 0.109569125016934 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PARK7 0.307273563629801 0.395695480084728 0.747820527895888 0.273219484191561 0.450800647095155 0.763947905803589 0.489412234030627 1.0 -0.478768657138276 0.236644723150733 1.18980682392338 0.0067949101357449 0.711038166785103 0.0656431955908249 partial_or_other True False False False True False False 1 cross_species_direction_conflict +DCXR -0.443261806359597 0.395766449814175 0.747820527895888 -0.510690096229951 0.327706384949804 0.676889991422347 0.930037570200239 1.0 -0.106460500530872 0.781810193990744 0.643062016858309 0.0317575606778751 0.536601516327436 0.0794170333570016 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MGME1 0.253673585251633 0.396084554456063 0.747962927194976 0.155396808458313 0.599886808257726 0.843257280459236 0.556093756324031 0.148757698730074 -0.272235150106458 0.387817289489488 0.283858606217573 0.432511480747949 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CDC27 0.155044222193106 0.397280057748036 0.749416267590453 0.196471320995031 0.278596263566666 0.641950971352435 0.275769051207451 1.0 0.404523145904453 0.205545898991761 -0.443479154127035 0.10654360470129 -0.0389560082225818 0.912650452426817 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CNRIP1 0.266637263392406 0.400552853524788 0.75237833153661 0.245190455642967 0.439923733269019 0.756769095948255 0.308328788743355 1.0 0.0379543950449746 0.950633272242692 0.0639482002767235 0.888307854837482 0.101902595321698 0.837473239766848 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACAT1 -0.221425464109391 0.401059172652315 0.752913005843376 -0.102231884863407 0.699990019793446 0.890099316991353 -0.402601514850308 0.347421543931997 1.46739406806468 0.0033272830542876 1.06479255321437 0.0176069758330302 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PAFAH1B2 -0.158182712193779 0.401562442794307 0.753098036882029 -0.0661548736447172 0.729268281463758 0.904135100480784 0.307294120901778 0.297263695934094 0.298284378664052 0.222386208574646 0.60557849956583 0.0360013361442554 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MSANTD4 0.322566065225606 0.402530209007169 0.753277693664303 0.274730871470722 0.470895726711952 0.774772803899764 0.187050861944283 0.744763002612419 0.514666181524059 0.18609646126915 0.701717043468342 0.118541499722005 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CHORDC1 0.21885017439282 0.403022986869006 0.753433688873013 0.361132610543481 0.166636949896623 0.546847691536137 0.0642814520007674 0.888756317097729 -0.418208384254612 0.190002666945131 -0.353926932253845 0.294325762660054 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC35G1 0.346548237007776 0.403073187565706 0.753433688873013 0.539659463454721 0.191235047762397 0.570403483290424 0.0532399700463778 0.947515172143523 0.759324616176501 0.130441550778813 0.812564586222879 0.142116828006145 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CSNK1A1 0.170837746624451 0.403410107467975 0.753668102254328 0.111549284515579 0.589959588391039 0.836894386999166 0.7741153533759241 1.0 0.454585950934995 0.141624755576244 -0.146060300797875 0.593954844453591 0.308525650137119 0.279962149767959 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MPHOSPH6 0.216352565323406 0.403605346112073 0.753672664352895 0.0905031622186983 0.73196167001217 0.904431845923655 0.539525637431691 0.183112824857045 0.0322967706903128 0.93029383911543 0.571822408122004 0.130175783253176 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DNTTIP2 0.305281995719561 0.403751083275005 0.753777238893883 0.0023701826962532 0.993685558336849 0.998542598236847 0.447185478635632 1.0 -0.0650360637225238 0.878678760833793 0.743297855454415 0.0162777791773385 0.678261791731892 0.0367790881754691 partial_or_other True False False False True False False 1 cross_species_direction_conflict +AKIP1 0.325401983647064 0.403804135554442 0.753777238893883 0.286952996035945 0.462950739196653 0.769320698854699 0.485708110714188 1.0 -0.131823996742719 0.754826919991959 0.797676916006052 0.0156295578613704 0.665852919263333 0.0491286738643093 partial_or_other True False False False True False False 1 cross_species_direction_conflict +NECAP1 0.180336155585762 0.404105346130969 0.754206159528155 0.294450068699926 0.171046772979557 0.551929043129023 0.0388363649905118 1.0 0.0089020704863516 0.985061381031034 0.0541310422041462 0.876837486235366 0.0630331126904978 0.869796887473489 partial_or_other True False False False False False True 1 insufficient_or_context_specific +P3H3 0.353492129761156 0.405286015172297 0.754675440597727 0.318400992980371 0.453106784292602 0.765092566410986 1.18008195825772 1.0 0.614256742729185 0.0235704956299622 -0.437995818309738 0.0622729642642479 0.176260924419448 0.4676484286314 reversed True False False False False False True 1 insufficient_or_context_specific +PDHB -0.18911398753307 0.405768685602199 0.754740244483982 -0.280474164466549 0.220848500826846 0.5925760086083 0.3438638620498919 1.0 -0.0627977284026068 0.868335967459898 0.567355282318271 0.0422907843958007 0.504557553915664 0.0777334804376274 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TXNDC16 0.28338801239996 0.405805682529051 0.754740244483982 0.0131612424452612 0.969312161792374 0.991666453895725 0.64852753427999 0.214070347206186 -0.121162795493039 0.786241638006412 0.527364738786951 0.276154178224236 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HMGCS2 -0.412364202497795 0.406521530470289 0.755244469242532 -0.294906739512365 0.55110482983817 0.817673523528865 -0.823867997828202 0.21075460129208 2.04848519192136 0.0060357621243576 1.22461719409316 0.0556752012051446 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SSU72 -0.180525967334953 0.407571625609342 0.755998106673125 -0.0603140272699822 0.787826075617345 0.926576536501901 0.124986876471943 0.707637678347167 0.353888461979482 0.166059377693518 0.478875338451425 0.0861448368966294 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RHOA -0.18383315055764 0.409119089293936 0.756680359827036 -0.319338449990876 0.145403060668197 0.532658823056677 0.0899179391340372 0.808056657821046 0.430421784405756 0.108405098424406 0.520339723539793 0.0741923107426822 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CMTM8 -0.371841630228222 0.409411636960416 0.756890873361557 -0.524316655774314 0.237547114570495 0.605329180588419 -0.54990510828653 0.121476060047674 1.08425283966086 0.0043578022554296 0.534347731374335 0.0941757914500886 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ANKRD17 0.12545951971628 0.410887774857688 0.758184407090466 0.10663525001304 0.48486851144011 0.781510814627977 0.284343226227449 0.112787880431167 0.123973137891681 3.0 0.284543521759535 0.22882836552574 -0.325001885981994 0.120031242346243 -0.0404583642224585 0.87403090303973 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FAM98B 0.250417078627255 0.41143010728054 0.758184407090466 0.105361543719439 0.721836155818227 0.901057712595039 0.5400644131778621 1.0 0.0705442023437507 0.86139670882348 0.211249446245743 0.431392464697122 0.281793648589493 0.340763435337417 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EFR3A 0.141688072187352 0.414519400639398 0.76054451688797 0.327863418893452 0.0441704792067061 0.393650849907072 1.08111828326943 1.0 0.172705542772808 0.578979051065045 0.0512927263330828 0.850464203916145 0.223998269105891 0.397329417577023 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MBIP 0.170757797893003 0.414560872768542 0.76054451688797 0.153323928462475 0.46350151216279 0.769320698854699 0.0453639573377167 1.0 0.299792944731092 0.530148719992553 -0.562903912206274 0.140232206285551 -0.263110967475182 0.548851241821563 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CORO1C 0.251798834935886 0.414843843391624 0.76076641167561 0.132594358185129 0.679518818396316 0.880829918309184 0.712741290796242 1.0 0.0368448185520214 0.909706000743012 -0.0690607148990371 0.766965637918028 -0.0322158963470158 0.906222422502304 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FKBP5 0.517887126229357 0.415351640728052 0.760937467084292 -0.062107252340022 0.921123009776884 0.97652542797714 0.517790717484751 0.393740993572358 0.567196636419938 0.340435510175023 4.0 0.124693970730359 0.876566872609043 0.838963422593001 0.129678479405668 0.963657393323361 0.10610738150025 partial_or_other False False False True False False False 1 insufficient_or_context_specific +TBC1D31 0.230129783499576 0.415875304107179 0.761209985113432 0.314211685730376 0.275862745762621 0.6396696093258 0.0109595120747235 1.0 0.956367823515369 0.0557035737491774 -1.07739202283636 0.0172879552599406 -0.121024199320996 0.826546796531131 reversed True False False False False False True 1 insufficient_or_context_specific +MANBAL -0.225356935617742 0.416582766961253 0.761738977065622 -0.232201755707433 0.401643347496074 0.730970076414215 0.705223315360532 1.0 0.208413221995263 0.629519424520374 0.525042201740714 0.104012536189577 0.733455423735977 0.050220216880846 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CD81 0.173625764138497 0.41787679090577 0.762345191205836 0.118564623392189 0.570177888079568 0.826196804464902 -0.0091574636540775 0.982685585789729 0.860480386337242 0.0121406469736717 0.851322922683164 0.0173311152728257 partial_or_other True False False False True False False 1 cross_species_direction_conflict +GPC1 -0.41112960727162 0.418222551409238 0.762345191205836 -0.711703816306702 0.135180211832347 0.521860900181769 1.73330536034399 0.0001767200854633 -1.0403627836918 0.0024012576418239 0.692942576652187 0.0317959043782194 reversed False False False False True False False 1 insufficient_or_context_specific +SRSF3 -0.191454321261525 0.418945932723369 0.762626061671264 -0.325208092717765 0.16793358580645 0.547713437832748 0.495872000702109 0.506024304486553 2.0 0.681764873797402 0.145569964861712 0.857057532615423 0.0242464293547026 1.53882240641282 0.0051288570433929 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NDUFAF1 -0.24197600230379 0.419493660945288 0.762716834627854 -0.230106843444733 0.443644910069867 0.759526992138424 0.222647322602829 0.602051276048176 0.56456992006472 0.0862179313723665 0.787217242667549 0.0391567750557942 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TMEM184C 0.25457696549943 0.420512534189174 0.763558734538902 0.0595635035382356 0.850879776723366 0.953740727286909 0.511121245459564 0.265658484600629 -0.175528243196588 0.65152281673194 0.335593002262977 0.430056822052887 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TNFRSF1A 0.151761989046405 0.420746850212981 0.763558734538902 0.124077437649406 0.510876184150997 0.796519013040946 0.38642415289713 1.0 0.136983067094941 0.719214521019672 0.239689317930488 0.41650965027022 0.376672385025429 0.223233953707952 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PQLC3 0.215994803256148 0.42084456362993 0.763558734538902 0.13192757105301 0.616174522176563 0.851916120639411 0.708786275041204 0.360057043740138 -0.431800747704772 0.451201653045706 0.276985527336432 0.725831244745298 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KNTC1 0.254037282702995 0.42093932751692 0.763558734538902 0.0857993355815585 0.791935559743574 0.927620871373898 4.03005216899966 0.0274591558939591 -2.77259869250282 0.0197933803351951 1.25745347649683 0.625804260474455 reversed True False False False False False True 1 insufficient_or_context_specific +TRMT10B 0.167119754596761 0.42100309683376 0.763558734538902 0.236469736307472 0.24425962626042 0.610669341516615 0.025391624708538 0.972679813201744 -0.400204473587545 0.420122371101311 -0.374812848879007 0.520719261096908 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC7A6 0.291245560508576 0.421005661868449 0.763558734538902 0.479783869258981 0.180191625715325 0.56319218007768 0.0433472665273403 1.0 0.666688160881158 0.156407450372314 -0.624894675770719 0.108069940374835 0.0417934851104392 0.937212997086554 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MMS22L 0.232425941125162 0.421049341966801 0.763558734538902 0.417045386709223 0.148346350801163 0.533583468169136 2.4454760827076 0.0346942575438244 -1.61079644725955 0.0453492134764488 0.834679635448044 0.516803625969098 reversed True False False False False False True 1 insufficient_or_context_specific +FAT1 0.408182520697708 0.421151917918342 0.76361359254368 0.603172233233714 0.236435213150132 0.605329180588419 0.960027601563584 1.0 0.713995876099758 0.0178928475890707 -0.445615632000695 0.0712633121987459 0.268380244099063 0.310129378501062 reversed True False False False False False True 1 insufficient_or_context_specific +TSC22D3 0.487859762087687 0.421893928727611 0.764522343498789 -0.0208246138967973 0.97243248394138 0.992040338141303 1.57851730586086 0.6098810815179649 0.208585294517317 0.179650355090646 4.0 -0.80538940344915 0.134475264984611 1.02568811654811 0.0431072728320296 0.220298713098957 0.675009479493338 partial_or_other False False False True False False False 1 insufficient_or_context_specific +ANAPC4 0.194890795975303 0.422157389915829 0.764522343498789 0.259277883692383 0.285979035606118 0.64687121300967 0.29187924890192 0.485187924806945 -0.27791936256265 0.416429267376065 0.0139598863392696 0.975282086098756 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SACS 0.248813070706682 0.422425128672242 0.764522343498789 0.608534811280537 0.0422418104683837 0.3908928278867 0.6668621547328171 1.0 0.343435632061032 0.514723341628365 -0.39585969862363 0.324028385324035 -0.052424066562598 0.924340526549175 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SH3BP4 0.291003363988115 0.422969806361996 0.764580101763606 0.235165090969664 0.518509066279456 0.800840369846825 0.5773729930865971 0.6601760771910771 0.0503756114576207 3.0 0.0589795490112388 0.894007251621826 -0.158558483772891 0.595422540175761 -0.0995789347616525 0.781559305591766 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DNAJC19 0.285331663477417 0.423154004317381 0.764580101763606 0.23759760208278 0.504055126104029 0.792706939691703 0.0221520978853912 1.0 0.194410815130097 0.729677278137171 0.17378224456382 0.668813693806432 0.368193059693917 0.412893298914688 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SOBP 0.21538351160873 0.423278148778962 0.764580101763606 0.317130011384672 0.239957323275674 0.606794054569195 0.180970952950105 0.809246007187784 0.0032166060490429 0.996161503721905 0.184187558999148 0.769914276490153 partial_or_other True False False False False False True 1 insufficient_or_context_specific +USP34 0.103371673632256 0.423439983489322 0.764610799671671 0.131958559745106 0.297986339031074 0.655992445264821 0.278024653119187 0.272242332270522 -0.263058218793098 0.223303275223859 0.0149664343260889 0.956201636867624 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPHLN1 0.123237858420707 0.423816455628702 0.765093252766925 0.161375308785931 0.291206712569421 0.650562943569181 0.104969184503528 0.778430650110939 -0.222342090839079 0.412629210849808 -0.117372906335551 0.713208610533296 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCAR2 0.189448985802852 0.424168550003458 0.765141218338716 0.205809625286827 0.390059540951074 0.722218665388488 0.0535266874221602 0.876566872609043 -0.32425403178267 0.174687341626434 -0.27072734436051 0.287870192905997 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ITGA1 0.217539770828864 0.424372202954207 0.765377813254273 0.509470464549025 0.0446484705682958 0.393650849907072 0.3951414636337821 0.214279764687688 2.0 0.339084342037463 0.323413013697967 0.173211964738111 0.567626556042452 0.512296306775574 0.106610423346805 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UTP18 0.179565062751084 0.424480113114895 0.765417352030835 0.234026017579278 0.292470031609473 0.651509781962399 0.617959750204441 1.0 0.126838853962939 0.769529305936767 -0.4319470644484 0.170092711139713 -0.305108210485461 0.382954015332693 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TIAL1 0.126186823022969 0.424539118535004 0.765417352030835 0.0731912309366532 0.641204719454122 0.864713172563113 0.0822751789861882 1.0 0.109668020712081 0.692468360812531 -0.365655507949873 0.0985944114091429 -0.255987487237792 0.263065134746535 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UEVLD 0.149639268316199 0.425029139391884 0.765579345650124 -0.0956343767793541 0.610716915968224 0.848390744855719 0.64105037071308 0.375341317135559 0.73162332783252 0.116923051248825 1.3726736985456 0.0355264612821072 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ECI1 -0.221135063373665 0.425156555085874 0.765579345650124 -0.349960717639638 0.193169272021593 0.570885363891703 0.6428376387501179 1.0 -0.287838805725397 0.572198191260242 1.39712377696901 0.0059324002168397 1.10928497124362 0.0222580071520408 partial_or_other False False False False True False False 1 insufficient_or_context_specific +COL4A4 0.231075578605434 0.42524970823658 0.765579345650124 0.0865047040972411 0.770060869182601 0.920562318243211 0.63935192904046 0.227474759316552 -0.917043954073265 0.0524014625971923 -0.277692025032805 0.60694958363392 partial_or_other True False False False False False True 1 insufficient_or_context_specific +YAF2 0.160796747960254 0.426316028453495 0.766526673775886 0.0352701484881378 0.857573260399766 0.956914759994669 0.153049417141484 0.597929527179738 0.0185825287072976 0.943946900587091 0.171631945848782 0.492329281571559 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GNB2 -0.223414189110586 0.42667725633397 0.767045542716509 -0.17083336303944 0.545500254384731 0.815346883112321 0.459958741452216 1.0 0.218824277740021 0.596676340079732 0.782068710980586 0.02607955423446 1.00089298872061 0.014632661942696 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PLPP1 -0.199551021622671 0.427120938637438 0.76739657291566 -0.134931211423476 0.5923893091205 0.838902274600198 0.286051657557691 1.0 0.491420702000691 0.140955028175922 0.199952582120092 0.479547286452757 0.691373284120783 0.0372249485721229 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CYGB 0.369403756927634 0.427966169471435 0.76823564211222 0.469311871460691 0.31601479143096 0.668232358888059 1.31497722193125 1.0 0.464369963186922 0.116744787556018 -0.0923973432130695 0.738714937413563 0.371972619973852 0.174153270173415 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GPC6 0.207041995227786 0.427994132118212 0.76823564211222 0.301701943437377 0.24649608605246 0.611559754402286 0.61101258776521 1.0 0.515701114035311 0.0937220878759213 -0.21500780062959 0.413364402720864 0.300693313405721 0.28948953379064 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HAT1 0.165647674847592 0.428760852130602 0.768870863528439 0.109408506574543 0.598608221857917 0.842680747516785 0.392567751669718 1.0 0.429824943639198 0.295032901955634 -0.143266921892293 0.678607557209557 0.286558021746905 0.450564127698631 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DYNLRB1 -0.174379197091912 0.429611398822208 0.769650460204262 0.0951650658682317 0.657868422028586 0.871691185476023 0.281747013466695 1.0 -0.192260268250692 0.504297082247917 0.813640483945156 0.0058754781246022 0.621380215694464 0.0255287889718218 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DZIP1 0.200380205533218 0.430654382578695 0.770220483803714 0.189544748292326 0.456660543951999 0.767131586801147 0.347010760494576 0.487745410379325 -0.860357771827834 0.0491508668288 -0.513347011333258 0.252406490513998 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RNF170 0.153259593814258 0.431353405135309 0.770572890300395 0.288181514101781 0.140605829697911 0.526401063874107 1.47042045655085 0.1896312044072 -0.933853212396794 0.249277506750844 0.53656724415406 0.659737659345484 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UBE2Z -0.13554469242068 0.431444284265002 0.770572890300395 0.0473254768111372 0.777535754892605 0.922929913000972 0.0666199932341543 0.876433216394697 0.506617882676091 0.0836662758285584 0.573237875910245 0.074510084015891 partial_or_other False False False False True False False 1 insufficient_or_context_specific +KRT8 0.158265310499895 0.432094256955031 0.770871167517325 0.247243488122941 0.224702315358186 0.59668185250295 0.491761553114691 1.0 0.660493785613372 0.117376574436309 -0.263930013589349 0.477307079631389 0.396563772024023 0.3083917133921 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MSRA -0.245988728989933 0.432140485434247 0.770871167517325 -0.179182218479372 0.564244367097313 0.823754286312897 -0.706435662757222 0.0577502725349127 1.51826547161103 0.0014550940008916 0.81182980885381 0.0271568768747579 reversed False False False False True False False 1 insufficient_or_context_specific +SEPT7 0.172435335248783 0.432439538494846 0.770890456640595 0.267163142471807 0.218119480799044 0.590436230426177 0.263141755005648 0.382062314642024 -0.22453973910453 0.3827846322956 0.0386020159011174 0.903533812295188 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CDH5 -0.502505699710089 0.432477042769682 0.770890456640595 -0.730219831888942 0.237774877997043 0.605329180588419 0.331379425554134 1.49191963692853 2.0 0.412179654307631 0.299324810267935 0.911707499597165 0.0103561095005984 1.3238871539048 0.0045073016630279 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DPYSL2 0.17770369126143 0.432583626289704 0.770890456640595 0.258250760688984 0.255442832586928 0.620277236994661 0.5254542788195621 0.511825593205087 2.0 -0.35154023875098 0.194275784091598 0.868368463743814 0.0045408369058909 0.516828224992834 0.0491567070782916 partial_or_other True False False False True False False 1 cross_species_direction_conflict +ATP5MD 0.230829311572772 0.432718652631443 0.770890456640595 0.497353110019641 0.0846707748971504 0.465302662671366 0.271431959587229 1.0 -0.0958117706426447 0.874025036276111 1.48472537585303 0.0039346027644 1.38891360521038 0.008588523543753 partial_or_other True False False False True False False 1 cross_species_direction_conflict +UHRF1BP1L 0.158613545363777 0.43390907417392 0.771645024729839 0.187436704397051 0.353719598663177 0.697398977158885 0.105868629928177 0.0823513667415585 2.0 0.541452888899393 0.0362355323313933 -0.347947067079121 0.108086709135515 0.193505821820272 0.409414986318457 reversed True False False False False False True 1 insufficient_or_context_specific +COL3A1 0.254301688599546 0.434339346897991 0.771655590441062 0.474492929747933 0.13022096553049 0.515512442645691 0.341156854679393 1.0 2.27323348836492 0.000829621270509 -1.89734741340731 0.0025576249055652 0.375886074957617 0.413142729518758 reversed True False False False False False True 1 insufficient_or_context_specific +ADPGK 0.13252929460549 0.43528881950442 0.771655590441062 0.0240249821344896 0.889482075102773 0.964481025873994 0.6445909590627329 0.0398168344802703 2.0 0.575985460040096 0.0527517941113112 -0.271035300810262 0.269085160998496 0.304950159229834 0.259412282682102 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PARN 0.15038700454834 0.435302363298212 0.771655590441062 0.12833177763443 0.506471961584795 0.793608039538775 0.113430065436444 0.730417369909899 -0.341657305001428 0.164456081136554 -0.228227239564984 0.398940133569479 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RALGAPA1 0.11866502974642 0.4353029418834 0.771655590441062 0.179795496794583 0.234618026140462 0.603430771105967 0.0505528907991641 0.888962750799615 -0.53598054978561 0.0457087687169773 -0.485427658986446 0.0804216787755617 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ABCC5 0.192605386826852 0.435783038454476 0.771992484693205 0.262935721393596 0.289801551484534 0.649071866901508 0.119898843765404 0.718861660614878 -0.399946790328535 0.124890832710866 -0.280047946563132 0.301661661010507 partial_or_other True False False False False False True 1 insufficient_or_context_specific +USP39 0.124192750806317 0.436541138531638 0.772803712377101 0.247772469062032 0.113769932405479 0.4924007041452 0.085899546238442 0.837991630610843 -0.124596735933881 0.677024933201021 -0.0386971896954392 0.917335477477782 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACO2 -0.190287122025551 0.437026053656741 0.77340279492254 -0.202105655034674 0.408536888918181 0.734801770489731 0.600601147591259 1.0 0.132141255743065 0.713712099680691 0.42830365829054 0.110052124829686 0.560444914033605 0.0639048045783564 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PREP 0.142425004135752 0.439334371005203 0.774700483102539 0.0979886324348945 0.589979628948171 0.836894386999166 -0.0188004497433795 0.956587192113681 0.452698717242131 0.0539345749736114 0.433898267498752 0.0835563993808325 partial_or_other True False False False True False False 1 cross_species_direction_conflict +GLOD4 -0.314667480373068 0.440086166035314 0.775050832527247 -0.0964998636343973 0.81728760816174 0.936399627452159 0.0567389988307124 0.917945009132389 0.788690381363591 0.0377064913080361 0.845429380194304 0.0396757426500509 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TRPM7 0.11974096570576 0.440773446836801 0.775222968743735 0.225889494537953 0.138144560022465 0.523810858054217 0.0918187616469103 0.0936120953029193 2.0 0.103068892898739 0.764723842807102 -0.233145563018816 0.363215532344485 -0.130076670120077 0.654964322503747 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMF1 0.129310948304389 0.440918159434185 0.775222968743735 0.0556996519637719 0.735727383014309 0.905764683303975 0.608148150089583 0.0425256210477419 2.0 0.196793242330289 0.507426561426719 0.0333582930851203 0.905512997700444 0.23015153541541 0.372523556216188 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UXT 0.238152503232896 0.442021336649376 0.775994730998025 0.347896710248085 0.258674763570332 0.622683117595888 0.126861995833993 1.0 -0.264974587262445 0.471559024707406 0.918847639817282 0.0075334272675244 0.653873052554837 0.0456503873008285 partial_or_other True False False False True False False 1 cross_species_direction_conflict +HSPA9 0.14121291479277 0.442639383703663 0.775994730998025 0.214608879925349 0.244808607661107 0.610669341516615 0.0376449813371573 1.0 0.00546539339677 0.992110993471489 0.539615206509262 0.107909261437301 0.545080599906032 0.125326330763281 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MPG 0.170598471827344 0.4429744571068 0.775994730998025 0.062592938881949 0.778302426177011 0.922929913000972 0.394729677568473 1.0 0.220794681806688 0.524063313509634 -0.429939082219974 0.125557142151087 -0.209144400413286 0.501314906807036 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KRAS 0.203108900365355 0.443025730555449 0.775994730998025 0.0487625700903736 0.854497577762238 0.955270806528397 0.247471140137463 0.365934213334963 -0.0448039548818441 0.862009110310585 0.202667185255619 0.413955319965021 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZC4H2 0.138508848755706 0.443341562547839 0.775994730998025 0.0818978020246993 0.650361752041933 0.869901306439436 0.8525688609931329 0.0735510497169336 2.0 0.274226356818712 0.700539517707229 -0.0405698073888168 0.943639832574209 0.233656549429895 0.713216351079149 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WDR75 0.129790861626874 0.443897380753199 0.776208657316836 0.0598862854211475 0.718081095487144 0.898496799968868 0.534719897154929 1.26961118558086 2.0 0.485554644148176 0.36218556900652 -0.0302020944444193 0.947864342226416 0.455352549703757 0.3439397292775 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CEP192 0.116354773101199 0.443978412723657 0.776208657316836 0.152820799643636 0.312327791050904 0.664562035049465 1.1006267872069 0.0115027170548461 -0.872068846033072 0.018173674864407 0.228557941173831 0.567117869475732 reversed True False False False False False True 1 insufficient_or_context_specific +SLC25A26 0.107563395550823 0.44436860087007 0.776376582489855 0.206082369332983 0.136804338757291 0.523136620282319 0.0788782794157984 0.919627505193177 -0.0002583155985944 0.999444943414147 0.078619963817204 0.905029514494205 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SOCS6 -0.219910139023124 0.444796864904728 0.776482357748697 -0.386252153380192 0.170551160550243 0.550991514163622 0.605083326522054 0.188275661925967 0.284486890211123 0.436515638173781 0.889570216733177 0.046475522565274 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PLGRKT 0.21615553089797 0.446144739275543 0.777806498888901 0.309759481981103 0.276448577336412 0.6396696093258 0.286816255423228 0.373827309733654 -0.0882263243822358 0.760595410708779 0.198589931040992 0.503646453560892 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TCF12 0.142140494403218 0.446259876524295 0.777878780971356 0.263753574710168 0.14651643977178 0.532796338690088 0.0308159803102608 0.931923787712434 0.0075178446707085 0.978440647116865 0.0383338249809693 0.89706283302159 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SMYD3 0.137985625563032 0.446551176384925 0.778137465707591 0.247037826214321 0.156488894371713 0.539558215777 0.528261161373419 0.0876626231530577 2.0 0.0478218860718554 0.895179480351654 -0.441741984919502 0.0828705795152564 -0.393920098847647 0.143345918951258 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MICU1 -0.143002174097505 0.446729326969243 0.778213057594642 -0.108229976484252 0.563415120455243 0.823754286312897 0.386346063782728 0.0822810218058334 2.0 0.259656719015382 0.448579178351756 0.263713432652796 0.325782525294587 0.523370151668178 0.0884823792628189 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ZFP14 0.142073894854287 0.447515023868474 0.778609336495366 0.136978643804609 0.463478297020674 0.769320698854699 1.12430430616828 0.0502021717433179 -0.378282020101228 0.353689831397683 0.746022286067053 0.165482169768914 partial_or_other True False False False False False True 1 insufficient_or_context_specific +METTL14 0.170413653960287 0.44782418095648 0.778609336495366 0.0634180759518113 0.775868484394507 0.922368490099607 1.1369498995558 1.0 0.29434471230421 0.621154857208238 0.0553926425385049 0.908885884946928 0.349737354842715 0.489381313893369 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SOS1 0.172562983401301 0.448587709438548 0.778763723220289 0.394001405507202 0.0775789381695335 0.4568200943636 0.448399900658995 1.0 0.0581734388610426 0.907914183245916 0.21360808421968 0.508214114828063 0.271781523080723 0.445744294814978 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MARCKS 0.220359557705203 0.448588544308408 0.778763723220289 0.275662001256463 0.350402813597754 0.69533895860028 0.0416788642846572 0.923035697096433 -0.0734535191293417 0.81865884741136 -0.0317746548446845 0.92923636652208 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BAG2 0.197225319768332 0.448867948457887 0.778815401151015 0.150078515529244 0.565916874634864 0.824113119711934 1.11532603329853 0.17083230919365 -0.411193347889549 0.475183761848385 0.704132685408978 0.370447494137172 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACYP2 0.111858157115603 0.449083932772057 0.778815401151015 0.039100220871133 0.793086079773852 0.927620871373898 0.0318042459884158 0.950353449158935 -0.0292915058381904 0.939401800498909 0.0025127401502253 0.996125065534572 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DCAF7 -0.107375094920334 0.451513860739391 0.780593309593334 0.0460628904212531 0.757120876554015 0.914454644719928 0.421346194922497 0.0993609883014627 0.131951669455449 0.547750918852343 0.553297864377946 0.0318542681418706 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PHKB 0.150202799951544 0.452092185227733 0.781209376699575 0.327312968628727 0.0869725310247763 0.468259042610703 0.0592866011268975 0.861279616670755 -0.123466773338275 0.607050056396181 -0.0641801722113773 0.820743047628618 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MIB1 0.115841506773449 0.45227426084247 0.781242531286769 0.211738201893443 0.170320850141081 0.550786520889233 0.277922911886063 0.265658484600629 -0.0793277431281207 0.728105291051943 0.198595168757942 0.386147035419858 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPP1R35 0.257192915930141 0.452787094916779 0.781361739217937 0.399243783591249 0.254074284648053 0.619121653608424 0.0225856646366209 1.0 0.120783640922074 0.711062796630788 -0.636460608017378 0.0228832164823849 -0.515676967095304 0.0689565508410934 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMTC3 0.165535982503387 0.452821612798629 0.781361739217937 0.288346585907123 0.175316613355134 0.557192294943862 0.453703709378218 0.416984035146931 -0.102538028772932 0.828009718620205 0.351165680605286 0.490123065276328 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ETAA1 0.200462383078894 0.453062484849676 0.781361739217937 0.239988971058309 0.372234494006583 0.710935562178275 0.672842122595453 1.0 0.0108169847442661 0.981025241777734 -0.716224708900182 0.0305640136606549 -0.705407724155916 0.0455405446158007 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPID 0.212576714896951 0.45306843791364 0.781361739217937 0.332472131956808 0.242041381940417 0.608802057364402 0.196495622227919 0.505374658311079 -0.584638154707425 0.02663241546823 -0.388142532479506 0.142558045113353 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TNFRSF12A 0.636272842977805 0.453452959389003 0.781703791703294 0.75759813703353 0.390637870559551 0.722269732670054 0.638317077941597 0.5111267465850979 2.0 1.07667564504882 0.0625182612187812 -1.76441587619104 0.0054451042448924 -0.687740231142223 0.21948582251453 reversed True False False False False False True 1 insufficient_or_context_specific +GALM 0.193879906988907 0.453488892231736 0.781703791703294 0.260391233470234 0.308478961617131 0.662330926800867 0.563136142237311 1.0 -0.114113113933768 0.814413161254705 0.814892038746805 0.0300421110018106 0.700778924813036 0.0657745545672101 partial_or_other True False False False True False False 1 cross_species_direction_conflict +ABCD3 -0.171356598426165 0.454341590241187 0.782206057740843 -0.105277606602401 0.644182291690528 0.866251949351307 0.113832351495352 0.813377867232966 1.07659765396479 0.0088713719306115 1.19043000546015 0.0085974855976623 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PAK1 0.148352506715838 0.454511489427782 0.782316971858253 0.156701546298088 0.429179422831439 0.748336221434264 0.924064022715897 0.178623954021266 -1.10637482255983 0.0519381891771047 -0.182310799843935 0.822373066974808 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM62 0.142777345981709 0.455968093201761 0.783678185217199 0.0321245342456378 0.867486434715839 0.958502690861149 0.443971233031317 0.441498486717447 0.07687488111436 0.872308022356201 0.520846114145677 0.30415857798935 partial_or_other True False False False False False True 1 insufficient_or_context_specific +COQ6 0.228450597982324 0.457566572432369 0.785187011788209 0.350340696911187 0.256382014696107 0.620986765579604 0.174971842071946 0.750642898097929 0.163759589001383 0.673524280748907 0.338731431073329 0.43431764597613 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DOCK2 0.343409984512153 0.458144816317224 0.785187011788209 0.037296819309097 0.93441579011391 0.981355009651115 1.99419565681352 1.0 0.914653187267606 0.254153990860419 -0.730072007502019 0.232885186032326 0.184581179765587 0.836869857623196 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATR 0.111645405983503 0.458728459729723 0.785187011788209 0.0879851594653609 0.561937880431587 0.823333352983166 0.699545033966532 0.0402882350939026 -0.433206767557763 0.110052124829686 0.266338266408769 0.398521341732133 reversed True False False False False False True 1 insufficient_or_context_specific +ABCC4 0.26900907085189 0.459225847997912 0.785651513174289 0.33104403147399 0.36028609745678 0.702830823178547 0.724120955150359 1.0 2.03470456859822 0.0155870992520791 -1.5714461343029 0.0166323205445602 0.463258434295323 0.595356573835764 reversed True False False False False False True 1 insufficient_or_context_specific +LAP3 0.193212623020872 0.45989218952684 0.785651513174289 0.190661544344887 0.465819828291295 0.771107831153887 -0.5801398820716 0.166260633359807 1.30106177567381 0.0054451042448924 0.72092189360221 0.0704794987806679 partial_or_other True False False False True False False 1 cross_species_direction_conflict +DNAJC15 0.240879298463233 0.459928432374302 0.785651513174289 0.556242700228315 0.0834477602754948 0.464779732481256 1.15158890916498 1.0 -0.0225269570066673 0.965542061567004 1.01158621710699 0.0104635314306098 0.989059260100319 0.0190311874009995 partial_or_other True False False False True False False 1 cross_species_direction_conflict +CSDE1 0.12832418064481 0.459950179254366 0.785651513174289 0.315028571637473 0.0730071147320185 0.450493029376212 0.099949750803527 1.0 0.117489861902466 0.735069404564085 0.179611378779892 0.490540317976835 0.297101240682358 0.284207157375764 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SRSF10 0.143591360929895 0.460940449993091 0.786209890498392 0.0790197305400261 0.688780394539804 0.884999569552245 0.54310752213353 1.0 0.187310647261943 0.468845290715915 -0.468534162410053 0.0416133123394121 -0.28122351514811 0.218841881055783 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MSANTD2 0.12967003434333 0.461100386932274 0.786296936877861 0.12765099783547 0.467819884580787 0.772583012794147 0.0384804569623847 0.932558334579471 -0.308968012369667 0.29704158002669 -0.270487555407282 0.404150250616725 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GNPDA2 0.205569126092132 0.462147667829682 0.786826394654489 0.541677554873905 0.060512341040459 0.429268745755419 0.790656346821471 0.0843281643144431 -0.50613816696781 0.16034173505405 0.284518179853661 0.528176496009991 reversed True False False False False False True 1 insufficient_or_context_specific +HMGN3 0.158669534076976 0.462671865246734 0.787421980235195 0.110416088483888 0.611298525123201 0.848775621810988 0.233387647625891 0.668694067676721 -0.893054049469028 0.047611203644688 -0.659666401843137 0.160448005828863 partial_or_other True False False False False False True 1 insufficient_or_context_specific +REEP3 0.152901323683352 0.463618102111167 0.788053563778485 0.327593834007858 0.109996892042872 0.486530031918157 0.0725902773872086 1.0 -0.0407531867903177 0.921968664906311 0.611395169899958 0.0398229355357616 0.57064198310964 0.0630426471272653 partial_or_other True False False False True False False 1 cross_species_direction_conflict +XPO4 0.151566199541182 0.464043673322488 0.788053563778485 0.235253384908562 0.252359442783105 0.618991529980024 0.127597187830146 0.779797272686504 -0.426130060574143 0.198237302404241 -0.298532872743997 0.417390734044782 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TGM2 0.47950060389147 0.464116911438266 0.788053563778485 0.460710285770491 0.482481150589706 0.780666906162311 2.20805763688886 0.5534159971010649 2.0 0.424845594274704 0.29825051222752 -0.323486775733607 0.362589375743519 0.101358818541097 0.807263673090137 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ENO2 0.407132786725818 0.464421980536561 0.788053563778485 0.314111005874794 0.571215245386376 0.826941582404853 0.774102051830433 0.175144956637759 -1.37280115038116 0.0147109685259325 -0.598699098550727 0.3086420834545 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ALG8 0.145254027480145 0.464447496862318 0.788053563778485 0.0940110641550979 0.639451763695131 0.864573988534439 0.809570352787808 0.171608477362346 -0.741969725932075 0.123210586559871 0.0676006268557327 0.920642268373684 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RPP38 0.184674671948733 0.464561979632249 0.788053563778485 0.144703085628279 0.567525347818009 0.824849995454606 0.159839697335649 0.814087629826335 -0.399859852485404 0.381005190421436 -0.240020155149755 0.677393444057004 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MGAT5 0.163702667757084 0.465162110693417 0.788691434832358 0.361118070447967 0.0936960984017656 0.473775578029617 0.222231043358735 0.560834622024947 -0.306812060891959 0.304811223362488 -0.0845810175332242 0.820404494767318 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NAGLU 0.19215817273346 0.465904377814213 0.788952759414185 -0.0233308518761081 0.93051597235397 0.980379965683386 1.08195901121876 0.0618133328834948 2.0 0.309115578821974 0.254112817032468 0.307238214301731 0.178741779891084 0.616353793123706 0.0260185753324253 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MPHOSPH8 0.126398103903866 0.466791334615955 0.789276364857353 0.0189427939175973 0.913239235570295 0.97354943452396 0.229261590169909 0.386966283877942 -0.397679524155941 0.0820378231582922 -0.168417933986033 0.491876517329037 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ADARB1 0.27373801136016 0.467363616251621 0.789887155496176 0.228557894358851 0.542754158268958 0.814401918734668 0.4496933619376379 0.3360706674343499 0.165049150997591 3.0 0.912274124787226 0.0084478644205417 -0.425174869812521 0.102674209796743 0.487099254974705 0.101529746413405 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DDX6 0.139657684942803 0.467789227506774 0.789974194500403 0.101806513404244 0.595129711615395 0.840585885650213 0.169374986064138 0.568560886856132 0.246115081192481 0.298131220701374 0.415490067256618 0.1058003605136 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BTBD10 0.137242012290411 0.468293967278537 0.79015557103108 0.304931629413103 0.113403294429963 0.4924007041452 0.381974284651001 0.553184205047736 -0.311887617703493 0.509274625041226 0.0700866669475081 0.917113143865285 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPINDOC 0.214430203473668 0.468487811958141 0.79015557103108 0.460719731775865 0.118484877906372 0.498589300094356 0.227621742380993 0.48851729371843 -1.01905486444247 0.0043738300087343 -0.791433122061474 0.0195993416424463 partial_or_other True False False False False False True 1 insufficient_or_context_specific +E2F3 0.212593493704543 0.4691931428088 0.790514987957659 0.391140897266913 0.168231771414845 0.54784064895804 0.472192861375209 0.0402336533482168 2.0 1.06317944769433 0.035257182541928 -0.503477157616525 0.177208110316161 0.559702290077806 0.230901793356326 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SGCD 0.327953635182062 0.470232619358195 0.791189800029295 0.511810210651723 0.257484852354009 0.621906676979798 0.355849190588074 1.0 0.211471628407137 0.675500646426359 0.0923298033649724 0.81232083950811 0.30380143177211 0.46503773726748 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RIN2 0.197337885786026 0.470970987282318 0.791914985505651 0.178970817505842 0.514133380224376 0.798491683514042 0.199919950641737 0.713363633773811 -0.218443598407547 0.597702027744582 -0.0185236477658102 0.972888434305505 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CLK1 0.150814070708176 0.471038654004119 0.791914985505651 0.051466789756861 0.808039483681894 0.932788199072101 0.442317135060352 0.163604793872922 -0.550531949922504 0.0612415803548641 -0.108214814862152 0.734870543265013 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DUSP22 0.157233161820534 0.472420200436402 0.792635953231448 0.0724914508966877 0.745729580479067 0.909628867935198 0.204119074059129 0.602336793198419 0.151832509706929 0.618624338698498 0.355951583766058 0.279125202202979 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCDC68 0.219218970256491 0.472893906933594 0.792635953231448 0.0038449045136832 0.989876454667493 0.996896452948454 0.499412193946458 1.0 0.503812350839525 0.118195739087715 -0.0746336193767398 0.805345337108401 0.429178731462785 0.152209911895126 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RPA2 0.225073687111167 0.473416714459037 0.793189112864913 0.257769960466188 0.414123023735676 0.736663818217135 0.357460083727066 0.619519226369392 -0.305395154016453 0.562115379051027 0.0520649297106128 0.942660682843177 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NSMCE2 0.135605327289494 0.474344220733446 0.793658825868543 0.175977072376637 0.348994645829634 0.694288655897113 0.451054721089212 1.0 0.0007705042082787 0.998400650016256 -0.522196617344531 0.0715348125966835 -0.521426113136252 0.0888153597380823 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PAFAH2 0.225428667202384 0.474406218039058 0.793658825868543 0.372909851758617 0.235631232371556 0.604841401840801 1.01033986755885 0.397851924844379 2.0 0.185443748370734 0.700539517707229 0.403847567354105 0.26830566467878 0.589291315724839 0.136799518146203 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BAZ1A 0.155408977313961 0.474624592589449 0.793680078545987 0.243638648608177 0.259369269287396 0.622885940784012 0.100423817459074 0.0656559232119747 2.0 0.421584170341515 0.151095589621829 -0.869051617799416 0.0060679108081842 -0.447467447457901 0.116783794681243 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WWP1 0.185817611771535 0.474702417687233 0.793680078545987 0.247744267387193 0.339244312219451 0.686946959803023 0.0015456539076103 0.996779540451992 0.142278893527479 0.572329206676406 0.143824547435089 0.600107432608579 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BRWD1 0.117855906500471 0.475185698620661 0.793680078545987 0.2306338243806 0.152897177626555 0.536485533522497 0.0407590563957797 0.892134688850524 -0.917287213605514 0.0021320799545968 -0.876528157209735 0.0039206351226402 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMBIM6 0.129003223525052 0.47593691875331 0.793913135797364 0.196360897705724 0.26996229153109 0.634515102250495 -0.413755389996928 0.361077875409092 1.34410887141885 0.0062158554724713 0.930353481421924 0.0355956608625232 partial_or_other True False False False True False False 1 cross_species_direction_conflict +ZFP90 0.127789341712661 0.478165699997641 0.795336281166835 0.0263965377387852 0.880592291128967 0.96227446663699 0.0840674914807144 0.846388159848326 -0.670594483831871 0.0389870773095688 -0.586526992351156 0.0877211108542968 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM159 0.348795741791736 0.479210923849537 0.796181592963709 0.413973893668376 0.403387241883716 0.732213929838129 0.4180165613381621 1.0 0.214816657876153 0.648098330341855 0.213148382219873 0.534688835450744 0.427965040096026 0.266047102580667 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TTC3 0.177185094799097 0.479247481043685 0.796181592963709 0.4294802730049 0.0769978119741468 0.455668688469891 0.0969619978838724 1.0 0.428372643950374 0.291992895520755 -0.293375974024811 0.385949760895611 0.134996669925562 0.740401598038351 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BBS9 0.160792737616733 0.480349559905557 0.796619563902443 0.349640190931796 0.119781689951921 0.500502724013779 0.8073281222542571 1.0 0.116764558240538 0.835828531983507 0.253826629682517 0.497927880185292 0.370591187923055 0.372934522026173 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC30A9 0.118345751353402 0.480573006892841 0.796659000421368 0.172895381147802 0.30152541869719 0.65922243713362 0.506641959240923 0.0730416911378014 -0.0810263798894225 0.748079804403157 0.425615579351501 0.107362574567559 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SNX14 0.135451840201246 0.48168728391029 0.797249465986022 0.162177338373956 0.396069506221213 0.726915037383597 0.144345077585212 0.664875881263502 0.0395629779562871 0.893908278737451 0.183908055541499 0.512805829615744 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ST7 0.15437552242987 0.48226982079815 0.797588466163357 0.270479196389884 0.2093819477696 0.581735440450297 0.0664743052832801 1.0 0.156849985977093 0.668525154297822 -0.357666887694301 0.196385267215777 -0.200816901717208 0.525590353617876 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FEZ2 0.12630610939173 0.483718229766748 0.798732729101864 0.125751629830932 0.485117883978649 0.78154724869473 0.0305428462274868 0.933277309558909 0.0823888493822499 0.748079804403157 0.112931695609737 0.682937653801204 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PCDH9 -0.188906642741713 0.484799172544124 0.799517285804571 -0.0801342485957039 0.76780557875673 0.919665960741623 -0.0613392642220882 0.942097357761498 1.16500671512677 0.0270888886945267 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-0.133995110391485 0.727027171340953 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SMAD1 0.146128363682619 0.493716092224664 0.806163702707703 0.0354047230139029 0.8718765719334 0.958683313195135 0.0189925141173445 1.0 0.710792874787422 0.0087105618424141 -0.418409917649742 0.0537761425872147 0.29238295713768 0.198717123755841 reversed True False False False False False True 1 insufficient_or_context_specific +URB2 0.346624515244446 0.494643415626313 0.80636503439555 0.0628041837244466 0.896996808608326 0.967531580672392 0.31650199060245 1.0 0.543126163647637 0.18816189864139 0.0385834469407338 0.920273026313064 0.581709610588371 0.130212706439522 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC25A32 0.154586719350145 0.49467951579655 0.80636503439555 0.20886361361142 0.354019751111467 0.697860442911663 -0.0718078813199312 0.924286122028271 1.02379047840044 0.0310833233870947 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0.447134872115937 0.359500395681013 0.472471291610984 partial_or_other True False False False False False True 1 insufficient_or_context_specific +STARD13 0.135014743750322 0.501950692964812 0.809630582793574 0.361083238203639 0.0491684997512674 0.404177169779245 1.10148046697427 0.30716153833121 0.128123181453439 0.125542119714168 4.0 -0.758651070258146 0.0137703296139341 0.541401802351177 0.0410363873743822 -0.217249267906968 0.401510282050849 reversed True False False True False False False 1 cross_species_direction_conflict +RNF150 0.176077474113138 0.502283390407954 0.809758441888408 0.355154569510142 0.174656402209946 0.556770016465158 0.5611725791382199 1.0 0.150663904958623 0.701769001297478 -0.50858563383488 0.10222268907907 -0.357921728876258 0.271152843246744 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RNF168 0.116445796775957 0.502702790290698 0.809939884005675 0.135538698059639 0.436127033872862 0.753498482020892 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-0.0080547426722541 0.98285785938443 0.104033087628645 0.79051040585562 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FOXP4 0.215501248454005 0.505204494701968 0.810384238083163 0.132282283406176 0.679787041010169 0.880961283783645 0.0326927578115627 1.0 0.13349879188211 0.683991356146034 -0.368741942650603 0.148635614820605 -0.235243150768494 0.385415807774682 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ENOPH1 0.182236644792285 0.505596610279039 0.810643737483082 0.0599018889263676 0.829104964139382 0.942947704141109 0.357758855786164 1.0 0.677825658004938 0.195785363034515 -0.359255555819721 0.378472649344769 0.318570102185217 0.536434278744994 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PTPDC1 0.204944565061862 0.505752725365642 0.810770919284914 0.107540566116035 0.725990812892776 0.903365569206837 0.104959701950015 0.05593573245005799 2.0 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0.814586416220053 0.358148826633755 0.136026400659007 0.523136620282319 0.111338690938132 0.705934598994412 0.255092413202426 0.245239377584947 0.366431104140559 0.129767090891208 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HDX 0.13339550739932 0.510632500466052 0.814720462196405 0.219514697380179 0.279091867662457 0.642114507827558 0.0487983960746966 0.947445687626968 -0.43403856016048 0.351364743466324 -0.385240164085783 0.479851180438503 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCT5 -0.234055245619501 0.511152014645979 0.815083892607991 -0.395967350682943 0.255270610251583 0.620144294301935 0.602090536394479 0.149029449922273 0.272852598215251 0.411368029427231 0.874943134609731 0.0345981392012996 partial_or_other False False False False True False False 1 insufficient_or_context_specific +FRG1 0.20922762523736 0.511836656929246 0.815083892607991 0.222742744284096 0.486401325903751 0.782147598778917 0.0036253369617055 0.992788933773383 0.303721203006112 0.195157978375258 0.307346539967818 0.228209112476063 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DZIP1L 0.165085843036675 0.511839951505113 0.815083892607991 0.0971171810206967 0.6963345224041 0.888447116319334 1.04111411168738 1.23420665565317 2.0 0.663338065596033 0.0417759887687647 -0.891501860658808 0.0080477022420879 -0.228163795062775 0.447637017828684 reversed True False False False False False True 1 insufficient_or_context_specific +LRCH3 0.0875493615170195 0.512247930967792 0.815118862872336 0.111759180305148 0.39447517532267 0.726080478554543 0.00504954653880707 1.0 0.0358339669327982 0.918811990670033 -0.483411194373203 0.0548465744701385 -0.447577227440405 0.0861448368966294 partial_or_other True False False False False False True 1 insufficient_or_context_specific +USP14 -0.116371402906615 0.512702437597054 0.815507202676114 -0.0363230185169369 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-0.177070338154594 0.593918349878547 0.839773552750704 0.374453789921099 0.20750648585278 0.550949671877457 0.0344719779351838 0.925403461798556 0.0070801914867158 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GYS2 -0.359519668860522 0.553635413082497 0.835279035628036 -0.586171001034843 0.329865274072563 0.678363374300374 -0.876420609597687 0.175144956637759 1.90223629369743 0.0054451042448924 1.02581568409974 0.0765101275112431 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PRDM10 0.110979954391892 0.55448840923081 0.835759484759448 0.244960851572806 0.167641393058872 0.547623080618609 0.147202974033575 0.813377867232966 -0.401706518026934 0.352211890745878 -0.254503543993359 0.61812560749942 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCT2 0.134333040629862 0.554860006048045 0.83617070280549 0.184798240447715 0.411002659124866 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0.555604231402483 0.836575795086625 0.113054751849781 0.625166562681143 0.856338486330344 0.438772457120577 1.0 0.585070060401451 0.0520141951887493 -0.444360033221513 0.0781598317302911 0.140710027179938 0.63260218701014 reversed True False False False False False True 1 insufficient_or_context_specific +CDC23 0.161553448285896 0.557345826132807 0.838241770984355 0.320482023647489 0.230832543204729 0.601518427890281 0.194392115664499 0.500340248402894 -0.402548684874449 0.093970436715718 -0.208156569209951 0.413869113485365 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PSMC6 0.0980093502196385 0.55743323989489 0.838253830908738 0.0834411591223815 0.617766028811768 0.852820833184446 0.260884687152567 1.0 0.0791249397744676 0.791534828666197 0.105254861881948 0.645453996921879 0.184379801656415 0.429709601109914 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPATA1 0.183531236780784 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0.560758535845379 0.840140057594203 0.239833388291113 0.306287861897718 0.661696690217148 0.0849779680677636 0.0962202673137442 0.0707290190215684 3.0 0.0884443848534966 0.872307625511471 -0.238736699531435 0.53152838684588 -0.150292314677938 0.735065265355837 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FAM114A2 0.172365332359676 0.561154355574381 0.840140057594203 0.113084864438702 0.702150480156913 0.8914937149467 0.245360808004706 0.33919882164384 -0.161287919040727 0.457523308087439 0.0840728889639789 0.74085055657171 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC25A13 -0.105011773285584 0.561383936366589 0.840214477157487 0.0328534686554813 0.854095745247515 0.95526155065304 -0.413688233220771 0.33070857151639 1.07999671467869 0.0112795430480853 0.666308481457922 0.0878573955024189 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CDADC1 -0.119195356683318 0.561827469301761 0.840401255746219 -0.0153567827659495 0.939869728408981 0.983658266508924 0.350194295639941 0.407526896855745 2.0 0.107328123896661 0.791534828666197 0.42722400862491 0.145375041819795 0.534552132521571 0.0951078954215272 partial_or_other False False False False True False False 1 insufficient_or_context_specific +FAT4 0.161596732526201 0.562301425107214 0.840521671356468 0.0269976694663913 0.923916119703625 0.978133591110337 0.311666656409686 1.0 1.4198707364958 0.0074098334235388 -0.681828274295902 0.0599677845550294 0.7380424621999 0.114144949637606 partial_or_other True False False False False False True 1 insufficient_or_context_specific +THNSL2 -0.272203431055927 0.562707519734075 0.840796206248566 -0.230005755270619 0.626200774728454 0.856624485564009 0.257876492044317 0.529224101292069 0.864507479241363 0.0154742191171605 1.12238397128568 0.0088126304675118 partial_or_other False False False False True False False 1 insufficient_or_context_specific +UBAP2 0.0995026353855178 0.56378006602776 0.841316109027778 0.24310308064552 0.159216279695482 0.543060696740211 0.392697502296344 0.0630621482410179 2.0 0.190982847306949 0.46758735670476 -0.691738212052914 0.0087055705365661 -0.500755364745965 0.0455405446158007 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LIN9 -0.180983618684148 0.566393175029512 0.842808157051877 -0.147239643149416 0.64262790288662 0.865003712470557 1.40029901103342 0.128389486250663 0.285839116174417 0.619274191642221 1.68613812720783 0.0519231343801239 partial_or_other False False False False True False False 1 insufficient_or_context_specific +KANK3 0.237838452355654 0.567676758486215 0.843228524674911 0.532614728433551 0.221312733119358 0.592913326464062 0.605980204299223 0.196006784554988 -0.149253872337376 0.701877835664097 0.456726331961847 0.295385758955682 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IL17RA 0.123483096501357 0.567939326790872 0.843361942652324 0.0510812245745238 0.809113865449296 0.932943578867351 0.141847417390344 0.74046846137411 -0.497568929416187 0.123265875777624 -0.355721512025843 0.30994077618049 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CYB5B -0.100896622081666 0.568039871833398 0.843392626468432 -0.152381514771791 0.390276923907783 0.722218665388488 0.21234936826309 0.692468360812531 0.786963924826809 0.0661222512958681 0.9993132930899 0.0356655198864627 partial_or_other False False False False True False False 1 insufficient_or_context_specific +KMT2C 0.0678671171750707 0.568236990323234 0.843566668142957 0.135766536331738 0.255788009888552 0.620544533180912 0.0019841771552607 0.996458519322138 0.307261768261806 0.221306890614896 0.309245945417067 0.258795510025679 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAN1C1 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0.162190859315976 0.572586354069035 0.844973897107944 0.0846439314137242 0.769254369357762 0.920253395046917 0.0413052828856586 0.922202787126516 -0.320418683851687 0.253287543987763 -0.279113400966028 0.358596425160826 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DNAJA1 -0.23734012251475 0.573629002418042 0.845154201441486 -0.203668767977223 0.629816585173917 0.85897526668397 0.355575746839129 0.372298926510108 0.790214032517929 0.0277895275422278 1.14578977935706 0.0091603772838437 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TMEM138 0.184336327364523 0.574116463005059 0.845230912907886 0.522043036369126 0.0998958503365969 0.478125555523304 0.7247382964003349 0.7852422907957249 2.0 0.21508519306914 0.680305011594828 -0.167518903189823 0.66847374461414 0.047566289879316 0.92558944958906 partial_or_other True False False False False False True 1 insufficient_or_context_specific +C2CD5 0.0933631527318364 0.575255110732973 0.846095496665806 0.0359119895270937 0.830613853717792 0.943790632272401 0.363900552915315 0.336684213763898 -1.00158260718315 0.0098922457446224 -0.637682054267838 0.0849640416547141 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PARG 0.102199153509248 0.575389814932799 0.846095496665806 0.185296879420779 0.305310536687975 0.661434040934444 0.113513989955084 0.731556142006226 -0.159613365512913 0.525213989981817 -0.0460993755578285 0.882674458570547 partial_or_other True False False False False False True 1 insufficient_or_context_specific +OSBPL5 0.129188741220428 0.575720397786291 0.846463718121105 0.0567956113413246 0.803924746647529 0.931585378484075 1.50246117227704 0.0730401331055446 2.0 0.313201948402935 0.271924106769673 -0.428777716523106 0.0908549198042559 -0.115575768120171 0.682847153251179 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ANKRD49 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cross_species_direction_conflict +UHRF2 0.0986904884289558 0.588540827028642 0.854510413985893 0.25046934831256 0.174805961146244 0.556905394035785 0.44459767646542 0.0742128078934692 -0.495569437446698 0.0331739034770925 -0.0509717609812781 0.845929199915557 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HDAC7 0.0949653075329411 0.588775794520998 0.854510413985893 0.103065603256006 0.55634825556995 0.820941061653668 0.367280691689303 0.349167810255371 0.144962203968713 3.0 0.294014031350911 0.417779787269149 -0.229747659262073 0.454046727634476 0.0642663720888386 0.862561185603264 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TOR1AIP1 0.125325119599433 0.589271333348743 0.854589030478346 -0.0040819561912405 0.986001768211118 0.995662563940518 0.15761885892684 0.280558987348765 0.0619059493458314 3.0 -0.0246107774980053 0.936257534403958 0.429862079666663 0.0503945679342623 0.405251302168658 0.0744816850310167 partial_or_other False False False False True False False 1 insufficient_or_context_specific +POLR2C 0.216239219134983 0.589341042897598 0.854589030478346 0.237822830542393 0.55487711631387 0.819814244898102 0.0411251089964612 0.934587009041752 -0.155818918487579 0.642031500457308 -0.114693809491118 0.769914276490153 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CBX4 0.203603128507104 0.589910182131301 0.854873832527718 0.116729688104597 0.755127431294019 0.914188214608675 1.23101930308164 0.9862839737022681 2.0 0.201386972707213 0.470476894376014 -0.130895957748927 0.575357470223477 0.070491014958286 0.79595420814348 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLIRP 0.154302964830278 0.589926564036523 0.854873832527718 0.14532330859638 0.612806779040907 0.850256876199477 0.329170835500661 0.243310525266007 -0.0488969474415137 0.856264763721083 0.280273888059147 0.279893024623986 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATP9B 0.0717719190364018 0.590293675242622 0.855148274315532 0.089803377956181 0.497086132127752 0.789146979692815 0.0090319546470271 0.978775837181156 -0.177176396250002 0.439056857375708 -0.168144441602974 0.493271491051335 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TRPC1 0.126128405395245 0.591462287403102 0.856102909714223 0.216299995415414 0.350768277324864 0.695476332769186 0.0199392352336228 0.960760068523928 -0.113959508211396 0.687724667074086 -0.0940202729777736 0.771021530930602 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPFIA2 0.314570454428986 0.592047869302032 0.856590737007819 1.17262638455185 0.0416092923896064 0.390826995201837 0.174022034147559 1.25706945844174 0.0770199392206028 0.0869598626279694 4.0 True False False True False False False 1 insufficient_or_context_specific +KDM5A 0.0770529682658465 0.592592755708451 0.85683915270093 0.0504834926077237 0.723509854987083 0.902186966924958 0.456591847391296 0.137558698109426 -0.074480534033979 0.791816584469999 0.382111313357317 0.180262186689717 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UHMK1 0.0960278169435869 0.593274278927367 0.857231399605192 0.151102463239878 0.403859312725826 0.732402823054958 0.5932402626301829 0.0190177913563055 2.0 0.296836721575654 0.375341317135559 0.204212220473447 0.446570272342363 0.501048942049101 0.100553067827497 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SH3RF3 0.171604068427307 0.59370148116643 0.857496612606726 0.308642048486535 0.341022181853665 0.688566111304456 0.566519476480818 0.19307245295606 0.170742797345045 3.0 0.326099547874426 0.682055542384383 -1.20788719049383 0.0629626311295878 -0.881787642619406 0.219033758139263 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RAB5B -0.098398893056533 0.595313841294453 0.858279787958938 -0.227482972658691 0.208521312221903 0.580875829578236 0.07691617875808501 1.0 0.165841678730545 0.679981237688498 0.946015564767501 0.0071779305864204 1.11185724349805 0.0066221187267941 partial_or_other False False False False True False False 1 insufficient_or_context_specific +LSM14A 0.0723436755713338 0.595959049052292 0.858279787958938 0.199563470812126 0.147424153924643 0.532796338690088 0.0639366981052017 0.826191364961233 -0.150280091743054 0.469176017085839 -0.0863433936378526 0.715501667648531 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ASH1L 0.0607208706913403 0.596070649240728 0.858279787958938 0.0683218447925774 0.547488114582745 0.815976780599184 0.17871103737121 0.489876178138051 -0.14674732679323 0.493336016100963 0.0319637105779797 0.904675408713168 partial_or_other True False False False False False True 1 insufficient_or_context_specific +OGT 0.0823019320549815 0.596113438634485 0.858279787958938 0.0579748509402333 0.708132930368986 0.893638108503159 0.422916115830939 0.123835076080789 -0.306902489156119 0.203723808986663 0.11601362667482 0.669256457541427 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SCAF11 0.0776898593777518 0.596596282571549 0.858506685483223 0.12442778293214 0.397980101036214 0.728473715359454 0.127194476344035 0.654324876820307 -0.019301149853774 0.940311244788927 0.107893326490261 0.667994232406943 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ADAL 0.174288248929029 0.597483405252841 0.859160820957922 0.0855883531009243 0.794622482976008 0.928199704380062 0.358682261323882 0.3978069413381271 2.0 0.0817545307822752 0.890560154231589 -0.145875856727896 0.720560790058018 -0.064121325945621 0.900420168448344 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAPKAP1 0.0892744951010969 0.598719451734614 0.859592963924676 0.213648020011618 0.205208344265779 0.578666837313374 0.232765164029279 0.449507232032576 0.181541372992382 0.464690207144757 0.414306537021661 0.128787731894526 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TIMP2 -0.105971419710521 0.598735239316355 0.859592963924676 -0.315665864664283 0.101086966598765 0.478335084675213 0.305236853961047 1.0 0.301821005955743 0.396911871643237 0.364675647311497 0.22880916430258 0.66649665326724 0.0490172263501473 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RNPS1 0.120913153512635 0.599383143815136 0.860015004516037 -0.0871836883963252 0.699158671618381 0.889654761580003 0.412893101329992 0.28500759472483 0.263816382532216 0.41249890567654 0.676709483862208 0.0650246442901202 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CCDC88A 0.0799341015767332 0.599517942151736 0.860015004516037 0.0663796140619254 0.660733591247241 0.87254849986096 0.51195602963679 0.0828042167522728 -0.87328498275559 0.0061425723558874 -0.361328953118801 0.19487999323351 reversed True False False False False False True 1 insufficient_or_context_specific +PLA2R1 0.157824781244757 0.59970698255216 0.860041305122755 0.286615534765633 0.33700530032078 0.685057785656405 0.426100597353689 1.0 0.340583745599008 0.223741818847007 0.0043648621870641 0.988665629929683 0.344948607786072 0.183136245163124 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ABI2 0.117530916476767 0.600152874296384 0.860041305122755 0.272692164524527 0.207928552723824 0.580700057930969 0.483620831940129 0.151884868967946 -0.479926809828504 0.101995886036925 0.0036940221116253 0.992760846097494 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WIPI1 0.132640890299885 0.601475248579588 0.861067888068242 0.176506319843266 0.491631690203244 0.785628482694998 0.0624786951085835 0.863241109047501 -0.0805452084540449 0.763816400139804 -0.0180665133454614 0.954475238299143 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CMBL 0.288050766965453 0.602608614255777 0.861872358346315 0.0690567480153685 0.898945614348012 0.967837995533705 0.0111559915992251 1.0 -0.396455998664024 0.407652589866014 1.14460872780438 0.0143739255189054 0.748152729140358 0.0856094410366032 partial_or_other True False False False True False False 1 cross_species_direction_conflict +MAP3K7 0.0812431211212341 0.60274489952863 0.861950514590718 0.217818627488313 0.149283550180601 0.533583468169136 0.5339206290177639 1.0 0.0111813319801183 0.980581669633894 -0.29952461122508 0.315204228624337 -0.288343279244961 0.37576124382096 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TBCA -0.0985469432452169 0.603892555123365 0.862868157695827 -0.0059031727474317 0.974991635669131 0.992692094136128 0.056819941794704 1.0 0.265044992675826 0.599588837549125 0.846872650569777 0.0403123544539278 1.1119176432456 0.0206382943196543 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RBMX 0.0829499943329481 0.604275057721455 0.862924906369035 0.125730512817968 0.426661901283815 0.747171397205924 0.434231392112116 0.086085848856072 -0.647279427346138 0.0121406469736717 -0.213048035234022 0.365873908142147 partial_or_other True False False False False False True 1 insufficient_or_context_specific +USP31 0.104659164471998 0.605350288692518 0.863570915824295 0.0548077281759927 0.788590586224158 0.926576536501901 0.275965245158317 0.47545824969876 -0.424617459598754 0.17475050027987 -0.148652214440437 0.688694142949238 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM38B 0.187860412747506 0.605984694416387 0.863859545319488 0.392000008106265 0.275060860557589 0.638542780511658 0.498416975150594 1.0 0.541085324475509 0.153373329176618 -0.120711682506099 0.725525822333594 0.42037364196941 0.229407973616812 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ARCN1 -0.113645696871435 0.606669226927614 0.864255777547661 0.161444420893053 0.479966801507908 0.780162456875056 0.333027986496827 0.602749819079787 2.0 0.0729635366505139 0.805181696523357 0.668675841313889 0.0088713719306115 0.741639377964403 0.0082417906738905 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ZCWPW1 0.161381139588047 0.607543637009882 0.864946833812072 0.342440989274543 0.288268992914006 0.648310091921223 0.889076107442003 0.344115334793445 -0.511628842915856 0.453007131686825 0.377447264526147 0.697917409096274 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NEK3 0.109005210098048 0.6084535790521 0.864960526893789 0.187078571067446 0.37163157697124 0.710253546178141 0.759896693878922 1.0 0.48011535819399 0.238381682783643 -0.701424508466001 0.0519979268681754 -0.221309150272011 0.586924288999175 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WWC2 0.0904463142419713 0.608541789112106 0.864960526893789 0.138984547791966 0.427809244280757 0.74781622535037 0.0486976187645831 0.885130826731918 -0.24233686743181 0.296212934090321 -0.193639248667227 0.433245129511408 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AHCYL1 0.129409496654962 0.608654116862521 0.864960526893789 0.079937467779422 0.754624259983433 0.913683823039574 0.342230413417349 1.06853746460963 0.075619939256761 0.123940167327422 4.0 -0.0656513200986146 0.844334212258955 -0.164983334573034 0.488044683679731 -0.230634654671649 0.353372242108082 partial_or_other True False False True False False False 1 cross_species_direction_conflict +TMED10 0.11525778233213 0.609692459688378 0.864960526893789 -0.136250106962267 0.537997955560186 0.812087893451657 0.324496128863992 0.463574461221254 2.0 0.172983007354235 0.682055542384383 0.80782600074511 0.0218847753945068 0.980809008099345 0.0150662145655684 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GCLM 0.146191528319842 0.61056164608411 0.864960526893789 -0.0454271730197602 0.875289621133145 0.960395245514428 0.695840227034431 1.0 0.0595540076198074 0.929157180641933 1.03969017950995 0.0307262134175377 1.09924418712976 0.0316214048323997 partial_or_other False False False False True False False 1 insufficient_or_context_specific +YWHAB -0.0777835703978412 0.610584973069699 0.864960526893789 -0.12493950357249 0.405463885226833 0.733444811508554 -0.0768142508994194 0.798163481014814 0.727692814045472 0.0066957512029457 0.650878563146053 0.0159316931008995 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RBM8A -0.173723289970094 0.610713776248277 0.864960526893789 -0.348753957682502 0.304777988654288 0.661341495477036 0.267425797208177 1.0 0.279833885515313 0.809937727594474 1.35925802070746 0.0410208069441593 1.63909190622278 0.0452139943909023 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SDHB -0.0811315855272387 0.610882906251201 0.864960526893789 -0.177047661488138 0.253104906965551 0.618991529980024 0.456216226334742 0.559813761025735 2.0 -0.263346192757764 0.597847856752033 1.12096809485476 0.0153966619099055 0.857621902096998 0.0530617583926483 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TTC28 0.0840992019852858 0.611411667589354 0.864960526893789 0.160539755254679 0.320219817871768 0.672472248121257 0.686718856621216 0.0093504465545216 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-0.220359478857068 0.698435327991522 1.69774539114627 0.0019014954372257 1.47738591228921 0.0065314512951213 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SOS2 0.0694304435992914 0.650275325433296 0.879673995626776 0.117917721352535 0.442157272549552 0.758062305003835 0.0850694540236753 0.829010029691934 0.0028848532521163 0.993384042372739 0.0879543072757917 0.788192203741488 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ETFDH -0.106337157878425 0.650755810027162 0.87981674520821 -0.324096116189044 0.161986048463873 0.543541307772207 -0.239418442552843 0.591076204481562 1.1944615142323 0.0062515815800947 0.955043071679453 0.0230210067511911 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GADD45A 0.257910904956841 0.653094346137116 0.881197457701684 0.0080135530359309 0.986487797527437 0.995776265418118 0.482868366933373 0.6213462853641379 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0.704969521071702 0.902846701052284 0.183263047368278 0.466386799455329 0.771256747133237 1.00333800266565 0.0930187180352344 -0.770618697315735 0.1045607216691 0.23271930534992 0.711700178196534 reversed True False False False False False True 1 insufficient_or_context_specific +BTRC 0.0665298416474508 0.705552084923822 0.903264085440247 0.110649607160034 0.524393241560801 0.804371707750212 0.0414381458024344 0.936257534403958 0.0985491033399545 0.786241638006412 0.139987249142389 0.727281137768212 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ABCC1 0.109000598684549 0.705679528545326 0.903317708824146 0.0625111534842543 0.827443801088319 0.942259214105446 0.5756180267379489 0.134971688676296 0.0511424660945218 3.0 0.682482681290604 0.11347364555644 -0.877974604676107 0.0292594919419219 -0.195491923385503 0.655135512854487 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EIF5 -0.0872912092834461 0.706415716322911 0.903636202064089 -0.180780883598167 0.441689264780633 0.758060094004529 -0.172264453481453 0.678092495376544 0.937510903934431 0.0094183382681845 0.765246450452978 0.0326940504494436 partial_or_other False False False False True False False 1 insufficient_or_context_specific +LIMA1 -0.108508259685196 0.706967012318949 0.903636202064089 -0.0645924790035893 0.822151225076848 0.938808681069134 0.594743304311936 1.0 0.475184053488443 0.0770679558603589 0.272093170035577 0.214336888545547 0.74727722352402 0.0116262027364317 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TTF2 0.0888551563122693 0.707030683260916 0.903636202064089 0.143857281420242 0.543758334485989 0.814904257700933 0.339158400959824 1.0 0.701752267557694 0.161051587824929 -1.18669342967232 0.0143335975597541 -0.484941162114622 0.344465504006763 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KAT2A 0.0966611065001309 0.707868711345236 0.903636202064089 0.0556441548334195 0.829342186800053 0.942947704141109 0.181429499818508 0.588980765963977 -0.58261432743825 0.042677106939985 -0.401184827619742 0.166847277941532 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BMPR1A 0.0723379935304608 0.708028279011739 0.903636202064089 0.124934742097037 0.518817645895936 0.800840369846825 0.320327273809186 0.191433240261074 0.0098489805388693 0.968177026503849 0.330176254348055 0.147729986826835 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TAGLN 0.161186528585073 0.708906129148866 0.904159327319851 -0.306697246948014 0.498118792927684 0.789518614144207 0.0691743065195802 1.0 1.79931356081425 0.0030777937094915 -0.961087431138053 0.0395491089550872 0.838226129676199 0.0803025570016665 reversed False False False False True False False 1 insufficient_or_context_specific +PEBP1 -0.0805974341017253 0.710100527454199 0.904731779097946 -0.0538468127964283 0.802975520992594 0.931018747695173 0.261253414933453 1.0 0.34520855692964 0.266795725680517 0.830843551805759 0.0078815058145552 1.1760521087354 0.0033875529244771 partial_or_other False False False False True False False 1 insufficient_or_context_specific +YLPM1 -0.0495797625959264 0.710413047436489 0.904731779097946 0.0230731641353798 0.862950643907771 0.958148375052923 0.540714703109691 1.0 0.383661715903013 0.117477396756443 0.0575700308176832 0.79916012390984 0.441231746720696 0.062389911734377 partial_or_other False False False False True False False 1 insufficient_or_context_specific +INPP4B 0.115539504261351 0.710874868108086 0.9047892704605 0.481360590790124 0.114827096024413 0.492613299848511 0.196802981523629 0.987035949663492 2.0 1.10181336906316 0.0735675907680753 -0.820982381199959 0.0859206295733011 0.280830987863205 0.66613947490803 reversed True False False False False False True 1 insufficient_or_context_specific +SEPSECS 0.117004787946663 0.711009109722402 0.9047892704605 0.0842485585943503 0.788508207576127 0.926576536501901 0.0183829275370497 0.966784957440745 -0.118219220624007 0.702664448406005 -0.0998362930869577 0.779118573675531 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RCC2 0.0906154254169707 0.714561805711202 0.906881060788421 0.113382888509336 0.647766266055071 0.86855377695836 0.259438151395509 0.538021773301436 -0.241225382671346 0.47119056023496 0.0182127687241638 0.967219868254546 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PHIP 0.072700107981274 0.71466133696002 0.906898364858641 0.193679667223471 0.330736349753407 0.679492971530739 0.0228611930531624 0.947310016023416 -0.284401929426771 0.214496589529309 -0.261540736373608 0.280226035736282 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CCP110 0.0903809988525529 0.715374393641337 0.907182958944614 0.12683168845174 0.609209831855783 0.848013066172034 0.0849174969575928 0.856375858040323 -0.49505965240972 0.130998981317865 -0.410142155452128 0.242662008264799 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATP2A3 0.157185078766124 0.715718938133846 0.907182958944614 0.155816915717363 0.718176178956166 0.898496799968868 0.454995555688474 0.473610591730003 0.0465160510546208 0.930808360715791 0.501511606743095 0.366126989373605 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RIDA -0.186546687905343 0.716189158593731 0.907182958944614 -0.310533905996389 0.544261908268538 0.815113627216777 -0.275995090765945 0.730417369909899 1.9973967945634 0.0088449896681713 1.72140170379746 0.0214221652310329 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NQO2 -0.09320953201525 0.716260385088303 0.907182958944614 -0.294725703578842 0.260927229779247 0.623697009737218 0.0158346823634873 0.966509885585696 0.81414930813137 0.008171363972995 0.829983990494857 0.0112596688390148 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GMFG -0.134610483963397 0.716505168726898 0.90727531439417 -0.416398854798675 0.233572098723714 0.602697571243329 0.722092035991218 0.241217135743348 0.604577566738505 0.151443457086388 1.32666960272972 0.0267325859802453 partial_or_other False False False False True False False 1 insufficient_or_context_specific +LRRC59 0.161180735931651 0.716838605203485 0.907479855364316 0.197441557434088 0.657943332989948 0.871691185476023 0.533290368944928 1.0 0.0669597701582589 0.859070568791721 0.030292900870205 0.921435776301235 0.0972526710284639 0.749402095143199 partial_or_other True False False False False False True 1 insufficient_or_context_specific +YWHAZ 0.0700525704180943 0.718541719835491 0.908655345313584 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0.253885509959534 0.619058479019113 1.02912271925044 0.057434522893914 2.0 0.067106852871855 0.846511722732485 -0.386379016906949 0.113887326708534 -0.319272164035094 0.21948582251453 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TCF20 0.0605026067839422 0.724187366543958 0.911478534667553 0.0897512377742385 0.602255701058943 0.844662020693454 0.333613661951863 0.274318800816134 -0.0394513436556105 0.895012792017366 0.294162318296252 0.292324188968276 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLU7 0.141891097054578 0.724400112179905 0.911478534667553 0.0585770305619564 0.882818724438975 0.962778177759102 0.019612260559998 1.0 -0.313610854383681 0.300161201299016 0.833797642942914 0.0064193613286015 0.520186788559233 0.0619802353058784 partial_or_other True False False False True False False 1 cross_species_direction_conflict +PSMB1 0.0750275454048934 0.724928605909856 0.91170890067853 0.258602768524174 0.229012163617389 0.600424738880655 0.334847281776569 0.0315489883977627 2.0 -0.155680919744922 0.633022601199974 0.616466010810585 0.0277273730893098 0.460785091065663 0.0951843105713379 partial_or_other True False False False True False False 1 cross_species_direction_conflict +CALR -0.140501867308667 0.725415367267064 0.911848573130595 0.0146876362250348 0.970985576068388 0.992040338141303 -0.300778084090741 0.340696064266725 0.92580186657202 0.0062158554724713 0.625023782481278 0.0405196423106954 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PSMD3 -0.0636289734650506 0.726260038966604 0.911848573130595 0.0491808831937995 0.787018966293083 0.926252207338503 -0.25276695923519 0.345628464834789 0.767241875656062 0.0057344291286823 0.514474916420873 0.0423639783755044 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GLI2 0.146357669916869 0.726431870947599 0.911861573352128 0.25036854938647 0.554585245987241 0.819814244898102 0.375949275848559 0.9427121617237579 0.221208876489031 0.148466326168368 4.0 True False False True False False False 1 insufficient_or_context_specific +ANKRD13A 0.0768516759301263 0.726582158679284 0.911927691915054 0.0006890029555963 0.996933423773996 0.998795540446485 0.5856135618267571 1.0 0.186425213643939 0.629519424520374 0.0623014556884097 0.852907445584465 0.248726669332348 0.445227759587401 partial_or_other True False False False False False True 1 insufficient_or_context_specific +JKAMP 0.109556389983476 0.72738747632183 0.912410238209087 0.154064193221371 0.625810449529447 0.856624485564009 0.0279076463154131 1.0 0.372195360358876 0.380835052229266 0.213291301996203 0.518831757870437 0.585486662355079 0.124712626925293 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DDR2 0.0911624321268842 0.72845362402481 0.913012579850311 0.134839756876467 0.60521776794468 0.846536831447265 0.3881316196659171 0.293702540316774 0.00701266849272275 3.0 0.581563789892106 0.0280434536098172 -0.654625897123097 0.011607751173525 -0.0730621072309911 0.780868540823982 reversed True False False False False False True 1 insufficient_or_context_specific +TMEM173 0.0972518984579556 0.728647153979793 0.913012579850311 0.0031549168358763 0.99117592189706 0.997505994031947 0.218618941000681 0.713431673907784 -0.270871620901061 0.545098763459379 -0.0522526799003794 0.927773731575923 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ITGA3 0.11040629152319 0.729192922467342 0.913012579850311 0.78931217486806 0.0187192172543967 0.329395826286535 0.378382463262282 0.0836137435881752 2.0 0.210593969893889 0.689027850424262 -0.367041197397039 0.362568393658862 -0.15644722750315 0.742071227965442 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TST 0.0950874032102564 0.729251286785155 0.913012579850311 0.150611308333405 0.589847783975827 0.836894386999166 -0.387965274046985 0.311119237938315 1.21878573525937 0.0042175563951795 0.830820461212382 0.0286753664825822 partial_or_other True False False False True False False 1 cross_species_direction_conflict +IKBIP 0.0819605017105002 0.730014017372216 0.91341181798433 0.228536022327663 0.322629285004271 0.672877524535327 0.751866031444915 0.0419624766365148 -0.912521806457999 0.0124444585396283 -0.160655775013084 0.655316934567585 reversed True False False False False False True 1 insufficient_or_context_specific +SIPA1 0.120615221998314 0.730705877043518 0.913744462129578 0.282138202626065 0.425234511613928 0.746032896912571 0.304773215966406 0.0373841190209747 2.0 0.138755478412107 0.706776681862378 -0.715953636036382 0.025211568619385 -0.577198157624275 0.0692517694624322 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IST1 0.0473036450865477 0.731003815501308 0.913798044525551 0.0425331439972566 0.756799572899562 0.914454644719928 0.115227898397501 0.652738215613244 -0.121171972144668 0.552115693668887 -0.005944073747167 0.982640950096168 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MGST1 -0.124574946240551 0.732090911940472 0.914014458927124 -0.0924796259077975 0.799502693890914 0.92964200904188 -0.716449984724815 0.159581462336951 1.74334788929982 0.0040237834364356 1.026897904575 0.0422357246427118 partial_or_other False False False False True False False 1 insufficient_or_context_specific +LRRN3 -0.210868593359637 0.732835957586527 0.914245982671855 -0.264324088848852 0.667824410884668 0.87545196549793 -0.184531760772283 0.808547530367938 1.73798106963501 0.0043578022554296 1.55344930886272 0.0131790242682145 partial_or_other False False False False True False False 1 insufficient_or_context_specific +HS6ST2 0.145456799753199 0.733476092413112 0.914603433769168 0.0528182878045379 0.902255995902041 0.968879048487973 6.87764253449047 0.0072329941728038 -2.32386071264964 0.0183125549347568 4.55378182184083 0.114835647828579 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SLC31A1 -0.0940380936616589 0.733769648549639 0.914656428499066 -0.0127064723634198 0.963845463536025 0.989935386867005 0.0283596083359915 1.0 -0.330409578627926 0.258840084741288 1.41136361931557 0.0007735858136339 1.08095404068764 0.0035440769053387 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RRAS 0.117481776605334 0.734143830051476 0.914790491218717 0.709210203795394 0.043092258445963 0.391483132487066 0.257432658549028 0.390728503032821 2.0 0.156650314468612 0.672837642400679 0.256493830181336 0.360910202998425 0.413144144649948 0.173079894750668 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPIN1 0.0740068110083849 0.734852360491762 0.914897217910565 0.251023237787212 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0.672472248121257 0.6499213320657921 1.0 2.93771795678441 0.0006690048699659 -1.56278204690874 0.0058359913855281 1.37493590987567 0.0475577653060964 reversed False False False False True False False 1 insufficient_or_context_specific +CHMP4B 0.0870801152883472 0.737595565639045 0.915857224746211 0.060961682514952 0.814847740470851 0.935641141872961 0.170015572676187 0.576539001976649 0.2291151705722 0.328473243385196 0.399130743248387 0.124543710208237 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BACH2 0.1009105200005 0.738156833208607 0.916230877617737 0.359974530913202 0.209722437021629 0.581956585220706 0.0480119494200202 1.0 0.105521800811146 0.844719580670207 -0.0695339653971645 0.865619746561642 0.0359878354139817 0.939518072481993 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ECHS1 -0.0940077107845438 0.738717115073508 0.916387651385983 0.0130640000027318 0.963188342124546 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0.919189349632913 0.22893036793246 0.464225382447915 0.769916994641075 0.506651309152521 1.0 0.109916756442089 0.750909193612088 0.088288882563826 0.738051566894112 0.198205639005915 0.474295673545989 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ANKRD27 0.0678186669320815 0.748359357185392 0.919189349632913 0.0348803057496832 0.868797093650393 0.958502690861149 0.213677346800623 0.469106347075739 -0.555680904450821 0.0339201394098583 -0.342003557650198 0.195992681413935 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ENPP1 -0.131641740363531 0.748641233342023 0.919194573976634 -0.310337944822426 0.452237802395186 0.764445519962917 1.54423374089288 0.0022844997831215 -0.798779845261057 0.0272605127895891 0.745453895631826 0.0690271209061359 reversed False False False False True False False 1 insufficient_or_context_specific +GRN 0.0837448985564407 0.751245166742271 0.919855385136123 0.274240786601813 0.302273837118951 0.659654231563018 0.42769948363518 0.129020645213766 -0.362105930418776 0.149439965149069 0.0655935532164041 0.822541066245188 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TRIM62 0.104455794331842 0.751927300640432 0.919922577799954 0.168993531382421 0.610774833457165 0.848390744855719 0.122940119951257 0.7694847729820808 2.0 0.449672000916489 0.519233517309339 -0.385991275891222 0.459979009676616 0.0636807250252672 0.929518022950857 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DOCK7 0.0845369835684807 0.752034740229815 0.919922577799954 0.217804021935604 0.412571121500223 0.735302527699488 0.403295859025136 0.16126081290809 -0.756115524243324 0.0111657045125426 -0.352819665218188 0.191570091471437 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TM7SF3 0.0695934485277254 0.753499571671329 0.920343414820209 0.0185812383296192 0.933758107945067 0.981304144333413 0.33039984818092 1.0 0.0865507790555493 0.843047533896762 -0.0248826655891839 0.943918697461471 0.0616681134663654 0.869564213942219 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ACAA2 -0.0900688348422189 0.75367067708081 0.920374733045188 0.0726939571306899 0.807603014827941 0.932788199072101 0.765082572026854 0.670771625344329 2.0 -0.454257671234755 0.358356614683552 1.2262348161171 0.0141416015773089 0.771977144882341 0.0922679441391236 partial_or_other False False False False True False False 1 insufficient_or_context_specific +AP1G1 -0.0438941533539937 0.753744520983763 0.920374733045188 -0.0842538096006125 0.542965941095349 0.814401918734668 0.463615270970746 0.139705138049258 0.472206627833127 0.0824287969503385 0.935821898803873 0.0088796131339789 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PKP4 0.0556593047629874 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0.107914391263947 0.713364952533236 0.895565656224246 0.3853591358210979 1.0 0.237239751912726 0.371076058725012 -0.476615535879722 0.048554785239719 -0.239375783966996 0.317856923814966 partial_or_other True False False False False False True 1 insufficient_or_context_specific +YIPF4 -0.0492723392959662 0.759793115480066 0.923589552317505 -0.112055013909132 0.485957670136614 0.782071323676502 0.257578941281461 0.521096519452704 0.486687553649646 0.124440111983785 0.744266494931107 0.0423588637368009 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DENND5A 0.0547510084146356 0.76053837827178 0.924236210611586 0.0865785443458217 0.626067840156428 0.856624485564009 0.4160461885549 1.0 0.624194473736025 0.0268790885456617 -0.316518220076648 0.175679193108721 0.307676253659376 0.218601813344828 reversed True False False False False False True 1 insufficient_or_context_specific +ZFAND3 0.054050002217195 0.761267516725082 0.924419521777892 0.194324561564567 0.261317533064476 0.624064807531042 0.16585623360782 0.6781014981582699 2.0 0.0361945403234987 0.917825730068964 0.133281988115407 0.580937569533995 0.169476528438906 0.503374028510362 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CPQ -0.0649229313772226 0.761531303959987 0.924419521777892 0.0515695099346624 0.807444762310145 0.932788199072101 1.85924364901713 1.0 0.0419798115318222 0.917441036545089 1.02042772377905 0.0032807208258581 1.06240753531087 0.0045163244044198 partial_or_other False False False False True False False 1 insufficient_or_context_specific +UBA2 0.0718517595750692 0.761652341347403 0.924419521777892 0.207243382651044 0.371630299114212 0.710253546178141 0.0710584964404392 1.0 0.107532472879412 0.764177252940569 0.0035982054579524 0.991101253554587 0.111130678337365 0.716399730280017 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KLHL9 -0.0949366005764247 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0.0269520169448486 0.877958107826816 0.961265342988232 0.245618737131825 0.379859363805199 -0.174230298392406 0.458864315665612 0.0713884387394186 0.799174291716166 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SRC 0.0986881046852849 0.764513762830298 0.925339482742438 0.13815453231379 0.677957473426275 0.879886294337383 0.684152832691812 1.0 0.213445759104513 0.577904763167055 -0.399392013285997 0.197048057964161 -0.185946254181484 0.585605216551667 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ELOVL5 0.103605827200358 0.764633296919682 0.925378077588033 0.032705253997299 0.925474049501499 0.978485542437683 0.333518186859364 1.0 -0.469250031354886 0.308754276357312 1.61541492662268 0.0029994447458525 1.1461648952678 0.0175044721399198 partial_or_other True False False False True False False 1 cross_species_direction_conflict +FKBP10 0.0966174083839496 0.766678538422913 0.926472703292791 0.333405905768094 0.306691783308517 0.661696690217148 1.16786674324536 0.0197342922539509 -0.822538182771218 0.0531351360962659 0.345328560474141 0.436225850880336 reversed True False False False False False True 1 insufficient_or_context_specific +DCAF15 0.0979271561264455 0.766955474947026 0.926701293716033 0.221151031495147 0.512416690616113 0.797713863097157 0.0243322930479199 1.0 0.427377615649923 0.270052228690645 -1.11589246874616 0.0071551859668259 -0.68851485309624 0.0744816850310167 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DDX20 -0.129940211700939 0.767813099201184 0.92677135653674 -0.24328842810857 0.573460556373224 0.828262182515527 0.520732774145067 0.279291369053755 0.458096867465213 0.197390308259075 0.978829641610281 0.0349680765679778 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SH2D2A 0.179742024810598 0.768396405152952 0.92677135653674 -0.545646697156143 0.314445212214378 0.666840881022273 0.169606774870384 0.859070568791721 1.13801632417532 0.042362259966393 1.30762309904571 0.0504747545196111 partial_or_other False False False False True False False 1 insufficient_or_context_specific +AFTPH -0.0514560321621156 0.768834486220736 0.92677135653674 0.146290961386241 0.40060471283365 0.730498196562639 0.652878366150416 0.112139023827128 0.533855295590539 0.0930949857093381 1.18673366174095 0.0092587363325423 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PSMB7 -0.0545153021560898 0.769777572689233 0.927299639143443 0.0282029277142107 0.881428507327229 0.962618478946739 -0.126326953917317 0.831215706531321 1.16186398990445 0.0129269215398764 1.03553703598713 0.0297616020955191 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ELMO2 0.064399196975068 0.770712485892859 0.927842922013318 0.166193281207597 0.453345244882282 0.765092566410986 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0.460969734937169 -0.293593332740853 0.281374577544084 -0.0418950589713737 0.90702147873637 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMEM209 0.0882009484225459 0.772327627872834 0.92844249340499 0.0499109899663202 0.868529137943915 0.958502690861149 0.170022976921818 0.680500614587848 -0.0083215667606346 0.982060307283685 0.161701410161183 0.653693107104274 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KRT18 0.0988022361104645 0.772596875753008 0.928502648135399 0.195329436229724 0.570617458305702 0.826426712486539 0.231906645214319 0.46194714998407 -0.370151425211647 0.162988592868205 -0.138244779997328 0.638742355600932 partial_or_other True False False False False False True 1 insufficient_or_context_specific +APBA1 -0.105385524949255 0.774434422140632 0.929567829577171 -0.508884382694243 0.159623128686889 0.543470168550846 1.13436874751031 0.200820081464291 0.350793759853714 0.537365686104042 1.48516250736403 0.0703116758008396 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PARP9 -0.068103234347571 0.774910350677331 0.929955097054846 0.0104348136333649 0.964526898109504 0.990230145109296 0.175197483710332 0.559961874912392 0.601298467374383 0.019243312152855 0.776495951084715 0.0110795028796332 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NKTR 0.0373229475847367 0.77579269784092 0.930313035920296 0.114882457342021 0.375990388182883 0.713334504660356 0.0055063131939583 0.987388076265519 -0.500204078229939 0.0425463636841992 -0.494697765035981 0.0520900391262909 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CBLL1 0.0848176532372239 0.777459077041696 0.931098226417468 0.102029484642735 0.734576672644735 0.904977889122883 0.0358648507778875 0.948978490920634 0.278238555070013 0.417515819530194 0.3141034058479 0.419977012673289 partial_or_other True False False False False False True 1 insufficient_or_context_specific +COMMD1 0.0427831706445459 0.778368610785899 0.931536589512301 -0.0554321522717962 0.717832664703143 0.898496799968868 0.150157249969734 0.690038981640459 0.612543037323113 0.0429971209886649 0.762700287292847 0.0259116057841746 partial_or_other False False False False True False False 1 insufficient_or_context_specific +FBN1 0.0767060904804798 0.7787302189542 0.931544631229313 0.34472266129582 0.180702679874613 0.563538010872213 0.463182671941249 1.0 1.4350528464194 0.0004554780848032 -1.12018979887986 0.0021551896597206 0.314863047539544 0.254127672023206 reversed True False False False False False True 1 insufficient_or_context_specific +GSK3B 0.0469520935006024 0.780152574371264 0.932297779310901 0.0878638118826917 0.599352773536913 0.843166766555993 0.151316559397393 0.580906900835266 -0.0304600544425799 0.904879342928437 0.120856504954813 0.622224972509088 partial_or_other True False False False False False True 1 insufficient_or_context_specific +STT3B 0.064062190292268 0.780534977507689 0.932313609287116 0.292397285936102 0.192701061554823 0.570885363891703 0.0784159809428915 0.796260500993484 0.135931545582149 0.549423948341805 0.214347526525041 0.361049572366105 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AP4B1 0.100593881764648 0.780606470451573 0.932313609287116 0.347263170625751 0.344136185464008 0.69073818751447 0.0539635392993898 0.921639668496131 0.155173466150993 0.661393228396416 0.209137005450383 0.604273763631279 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NFKB1 0.0649025499042332 0.781617037552739 0.932510028396219 0.142449865847435 0.537481497460115 0.812087893451657 0.346287108998323 1.0 0.152293714725988 0.5708428850004 -0.0944650376561189 0.674608220210568 0.0578286770698686 0.822373066974808 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VPS45 0.0354539437768269 0.781655024749625 0.932510028396219 0.0757834015359369 0.546414621036949 0.81552807024429 0.781937954016034 0.0644356815345982 -0.486735595832895 0.157503364668176 0.295202358183139 0.457839861594272 reversed True False False False False False True 1 insufficient_or_context_specific +PCBP1 0.111754757755337 0.782780921546154 0.933325914137131 0.59666562597822 0.153100105370646 0.536485533522497 0.471163705332792 0.4016056571139529 2.0 -0.0899760607579146 0.815171844574446 0.85666530423827 0.0092846116215043 0.766689243480356 0.0208617282371127 partial_or_other True False False False True False False 1 cross_species_direction_conflict +PRPF39 0.0532381426907183 0.784150834170564 0.933597104428259 0.14728745245395 0.455540420054151 0.76683605786539 0.0825150519740221 0.834981566938799 -0.655925961026198 0.0335484455130118 -0.573410909052176 0.0656431955908249 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GINM1 0.0550450151486378 0.784514629436873 0.933597104428259 0.124639870389104 0.544436683843873 0.815113627216777 0.0252795129525303 0.935285427653295 0.214208721570506 0.294123166979309 0.239488234523036 0.271811642806647 partial_or_other True False False False False False True 1 insufficient_or_context_specific +OGFOD1 0.0852158509924837 0.785984279760269 0.934191379681293 0.110269635651858 0.726690046299906 0.903365569206837 0.7636732602463501 1.0 0.124281272785002 0.758245356647438 -0.343204407170121 0.240823712817243 -0.218923134385119 0.508843219675529 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CASC4 0.0420723828848533 0.787505815627892 0.934842185900527 0.0544072308915288 0.726816520906622 0.903365569206837 0.585423027468782 0.043022697069778 -0.718234659485732 0.0116113775091985 -0.13281163201695 0.636823625502751 reversed True False False False False False True 1 insufficient_or_context_specific +UQCC2 0.0928765030708344 0.787969965051713 0.935200252697671 0.10140571001685 0.769376332134613 0.920253395046917 0.178247788546426 0.690507296191996 0.355276660372838 0.287259450148033 0.533524448919264 0.146406527335482 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PIGQ 0.0844151585090328 0.788103170786618 0.935200252697671 0.103183697448075 0.74368925645411 0.909374800884141 0.7665580970354441 0.0250355727932386 2.0 0.0277415729415187 0.929619161467188 -0.133867248815781 0.522266989119494 -0.106125675874262 0.650797169258666 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HNRNPK 0.0556766508422606 0.789686401678967 0.935918080678688 -0.0725918885850358 0.727630928833006 0.903590607694528 0.129344446127508 0.0484254834447588 2.0 0.387033944658132 0.137989000503087 0.503204755164786 0.0345705918870089 0.890238699822918 0.0051589025303074 partial_or_other False False False False True False False 1 insufficient_or_context_specific +STRAP 0.0665253996392487 0.789957625885795 0.935918080678688 -0.0573511867432413 0.818140275341458 0.936969847820274 0.0848890403629707 0.841059384980579 0.652299512699354 0.0325262408585793 0.737188553062325 0.0298248636211815 partial_or_other False False False False True False False 1 insufficient_or_context_specific +MXD3 0.0895791622007246 0.790075474456738 0.935918080678688 0.11572713322567 0.732600487554694 0.904431845923655 3.64410846846234 0.0197806586967602 -3.20142373182067 0.0108050520501676 0.442684736641676 0.841222559462295 reversed True False False False False False True 1 insufficient_or_context_specific +DHX9 0.045356754779201 0.790285354722763 0.935918080678688 0.0997127322897406 0.560626967432706 0.822697818631225 0.129691037086488 0.623447029066316 0.0453049019287884 0.845885872948085 0.174995939015276 0.432227168072906 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RHOJ -0.0874934888250754 0.790673955782953 0.935918080678688 -0.275840838849936 0.4137307384715 0.736373758729281 -0.128352492977323 0.718083284330297 0.617493299684499 0.0337427903725098 0.489140806707176 0.0938938896800352 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CACNA2D1 0.0822867181243502 0.791155174475295 0.935918080678688 0.4182171943656 0.175814204252559 0.557945366367344 0.826820107584983 0.0169563212045969 -0.635953859953734 0.0375856405458734 0.190866247631248 0.537770895203341 reversed True False False False False False True 1 insufficient_or_context_specific +PRKAR1B 0.0681758627712141 0.791609005256507 0.935918080678688 0.139325722442491 0.583977230043444 0.834132995585234 0.946052675290999 1.08669986749996 2.0 2.05395559416414 0.0373474645813225 -0.684788167320027 0.246376203373713 1.36916742684411 0.159946698170558 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SAR1A 0.0527853394757033 0.792973658990762 0.935936945981962 0.12961648976324 0.524449244203654 0.804371707750212 0.31897077570255 0.475446632323443 2.0 0.0315817687286174 0.924777329702809 0.0351584935248836 0.893028423203212 0.066740262253501 0.800098332000689 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ANXA7 -0.046220546928614 0.793466360711819 0.935936945981962 -0.0804184406919139 0.648020313736923 0.86855377695836 0.327850503187187 0.188107042079834 0.474147383884211 0.0390445021264397 0.801997887071398 0.0065314512951213 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ROCK2 0.0522035568044478 0.793479339009862 0.935936945981962 0.214906936994359 0.263801320800585 0.626379950271573 0.246507450203288 0.393536073133442 -0.57008729744198 0.0340010371508872 -0.323579847238692 0.213499753016452 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KPNA3 0.0511641052561897 0.793687161108671 0.935936945981962 0.147805312095435 0.461650129950621 0.769126302007068 1.01153341162982 1.0 0.126950798139759 0.727576365037144 0.23160028784677 0.377245045553714 0.358551085986529 0.218130060701352 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MAPRE1 0.0863553085225871 0.796413824657681 0.937254065233556 -0.147905954548507 0.656351515019044 0.871684912617742 0.428313735939773 0.100543576983252 0.0059743836204857 0.98218314043307 0.434288119560259 0.0806422763737832 partial_or_other False False False False True False False 1 insufficient_or_context_specific +FCHSD2 0.046053756716183 0.796625490677112 0.937254065233556 0.271523006110859 0.125424865272115 0.507759097984276 0.521045426376772 0.303202969119867 2.0 0.0090133980509882 0.980581669633894 -0.360676629317338 0.150116572870237 -0.35166323126635 0.179434782170288 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IMPDH1 0.0912237104264001 0.797031912482197 0.937262024585861 0.259371663985553 0.467939446701012 0.772583012794147 0.423877837044521 0.353629376601583 -0.942773409884245 0.0264819574183372 -0.518895572839724 0.231990552597079 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZFP2 0.0879414277289878 0.797285852354762 0.937262024585861 0.0497867750697716 0.884238443529076 0.963081098449005 0.0244695808668697 0.975282310145455 -0.0419999629460475 0.942139818202399 -0.0175303820791778 0.980740684834508 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CEP170 0.0510574243793676 0.797621426130222 0.937262024585861 0.256963940279379 0.196377051112267 0.571879675616801 0.107413043066538 0.755691883091486 -0.674014937947586 0.0207776051175688 -0.566601894881049 0.0526484019359067 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATP5MPL 0.0679305741992676 0.797820239150444 0.937262024585861 -0.182956280944618 0.497883185453136 0.789518614144207 -0.0343561790615493 0.950633272242692 1.38660562102617 0.0037510074301774 1.35224944196462 0.0065676280893407 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ANXA2 -0.0818850945133439 0.798476792071148 0.937620014490837 0.148186533178867 0.629424880017603 0.858587581812126 0.3070062786747511 1.0 0.229720888925025 0.474725275062832 0.763632759681181 0.0132242980310499 0.993353648606205 0.0063057817677493 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CCSER2 0.0313931567990821 0.800189596263921 0.938694084061061 0.169650594444984 0.179254914537713 0.562350982890208 0.286925067322126 1.0 0.195509305148267 0.541632329569248 -0.274760641735436 0.279962686280791 -0.0792513365871697 0.797472073234776 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KIF3A 0.0613106324806499 0.801228908362347 0.938887326802403 0.168275256242155 0.481018647829985 0.780361844466653 0.5105107154686429 1.0 0.44027571860622 0.237230979392939 -0.0883249383400217 0.786241638006412 0.351950780266199 0.307404621490251 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CHPT1 0.0682421826428335 0.804119532176865 0.940272375595182 0.0756879428905931 0.783368487769338 0.924938995064714 -0.536406230901545 0.102373850277688 1.91729723806524 0.0002767098815796 1.3808910071637 0.0023880569904632 partial_or_other True False False False True False False 1 cross_species_direction_conflict +PDS5A 0.0299044495600903 0.804765872432289 0.940272375595182 0.0425906319327908 0.724179168079319 0.902378599287888 0.0890641412356241 0.0660444567414056 2.0 0.288184928626803 0.243908828450365 -0.29437287174042 0.171225281101178 -0.0061879431136163 0.983376299371958 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MDH2 0.0976171793052947 0.805683537248178 0.940766067934777 0.168862163733166 0.673691452496686 0.877738560778784 -0.0648964082135089 0.837171010753131 0.626441117585383 0.0126359129827135 0.561544709371874 0.0286182423681076 partial_or_other True False False False True False False 1 cross_species_direction_conflict +PRKACB -0.0501738797247724 0.806333399287552 0.940976663404657 -0.170088967172021 0.404439972049694 0.732758892415649 0.119953460857997 0.693132695851019 0.525020846510594 0.0348949590181904 0.644974307368592 0.0219026983748615 partial_or_other False False False False True False False 1 insufficient_or_context_specific +RIC8B 0.0357071888009193 0.806576646051991 0.940976663404657 0.0794172157869231 0.583489956596311 0.834132995585234 0.374300159631475 0.169206931648686 -0.0678460481230642 0.787585913143713 0.306454111508411 0.223233953707952 partial_or_other True False False False False False True 1 insufficient_or_context_specific +POLDIP2 -0.0451617888489489 0.807994821956612 0.941508256818038 0.128974631910831 0.501077420946355 0.790819493321426 0.376816363114124 0.258358019098324 0.221334681244054 0.42411723260072 0.598151044358178 0.0607086442084818 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ARL14EP 0.054704061593813 0.808111556073775 0.941508256818038 0.0652698926566438 0.772323836668265 0.921016314566412 0.542285406669097 0.076838535847698 -0.639535362046449 0.024450824935175 -0.0972499553773527 0.761258304249313 reversed True False False False False False True 1 insufficient_or_context_specific +SENP7 0.0459767485421183 0.808207213603234 0.941508256818038 0.0610871710758599 0.746937626059741 0.909830759894547 0.0784117749847864 0.820810819173171 -0.466871705468735 0.0688639416647823 -0.388459930483949 0.146727923803177 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GFPT2 0.140815123431518 0.808613967324171 0.941508256818038 0.0771118344435356 0.8943222862066 0.966256109063578 1.59128129244142 0.860283779051042 0.185159353301678 0.071500614155811 4.0 -1.32227149155069 0.126291368437372 -0.73180885844765 0.355408290279068 -2.05408034999834 0.0264333048593353 partial_or_other True False False True False False False 1 cross_species_direction_conflict +UGT3A1 -0.186531537739075 0.809125108494732 0.941564817022646 -0.0357973888554197 0.977901452266387 0.993500350721674 -2.76054980628807 0.0048246714597431 4.21098508664893 0.0002835376344263 1.45043528036087 0.0195092797813903 reversed False False False False True False False 1 insufficient_or_context_specific +GDI2 -0.0407514639454279 0.809686529989972 0.941564817022646 0.207938095752983 0.224547160891846 0.596419855269462 0.5667461243167901 1.0 0.350449201544809 0.248857619206216 0.861794032467328 0.0058754781246022 1.21224323401214 0.002729355358263 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CDV3 -0.0676970650115582 0.809700608491129 0.941564817022646 -0.382562381954215 0.164518145666439 0.544850245278 0.0509090726256298 1.0 0.455946811081497 0.196752049273969 0.380250468300564 0.196151448503904 0.83619727938206 0.022684873837649 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CDK17 0.0472493858250773 0.81046461217822 0.941564817022646 0.0923937226407012 0.634664869407384 0.861847932958146 0.5401830144303761 1.0 0.112887610655923 0.688936764998849 -0.120408802559707 0.588824226499304 -0.0075211919037845 0.979598973540916 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RFWD3 -0.0515728569234041 0.810774703481924 0.941608109048747 -0.0385155251579805 0.858245318137971 0.956914759994669 0.423717053015873 0.375341317135559 0.501029749518879 0.168572846240474 0.924746802534752 0.0398810979916504 partial_or_other False False False False True False False 1 insufficient_or_context_specific +EPHB4 0.12150203090534 0.811614884516413 0.942272921786265 0.0296527754848539 0.953779863909645 0.987292667741163 0.0387327257156488 0.908381786429681 -0.0902698154564398 0.707860106483928 -0.051537089740791 0.850528417945562 partial_or_other True False False False False False True 1 insufficient_or_context_specific +RNF130 -0.0494359892678218 0.812460332995554 0.942866457945998 0.10388949521367 0.624162276512248 0.85594302057622 0.4953690344097029 1.0 -0.297329640848466 0.36218556900652 0.931127884935672 0.0061328296656521 0.633798244087206 0.0405196423106954 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TAF1B 0.0381166664398198 0.81248333343367 0.942866457945998 0.145162709704395 0.385095058547113 0.719652702248211 0.213859161009745 0.797632677132467 2.0 0.0416043553450926 0.948978490920634 -0.442998101454049 0.298016090779329 -0.401393746108956 0.391579376108947 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MID2 0.0501668627754455 0.813057002069908 0.943324816247702 0.148364338261941 0.483108399584613 0.780666906162311 0.642067553440598 0.189192105186794 -0.208766051218801 0.590413112114554 0.433301502221798 0.345624235811534 partial_or_other True False False False False False True 1 insufficient_or_context_specific +KAT6A 0.0357116534367397 0.813711713049986 0.943408262176069 0.113131657649783 0.447605883077295 0.761936901734662 0.0444145575946806 0.886325851682783 -0.0433216755470517 0.856631457818978 0.0010928820476288 0.997062000180735 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HSD17B4 -0.049272457354921 0.815281154249061 0.944452318033968 0.0166393779783003 0.936903674791803 0.982599483307029 -0.428334054322177 0.310036261088563 1.07419835160943 0.0123229858068631 0.645864297287249 0.0979990966789529 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ARRDC4 0.07303883971103 0.815908177468998 0.944664919210897 0.0915298388212921 0.770746124958421 0.920631444062254 0.4616136368805 0.165351828178807 -0.583194158714701 0.0524291093300827 -0.121580521834201 0.720649186054194 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UTP20 0.0519049322429667 0.816924067577444 0.944697076175537 0.0709896676903229 0.751177407785374 0.912125482621964 0.0612920925934531 0.883206679897385 -0.337598051727814 0.229404024924746 -0.276305959134361 0.369287967300446 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CTNNB1 -0.0420170268770117 0.818556303561274 0.945667865279361 -0.120418345538362 0.507776621787918 0.794484134953152 0.6452111814775999 0.5687780198464369 2.0 0.441885862622918 0.0928743702061991 0.102633230909495 0.665122964155281 0.544519093532413 0.037211590377527 partial_or_other False False False False True False False 1 insufficient_or_context_specific +C1GALT1 -0.0535290610240827 0.819981345304553 0.946029511818221 0.184970646699007 0.427012174231644 0.747434316946782 -0.0726456736880186 0.84254452723701 0.60665316746449 0.0255419427774061 0.534007493776472 0.0563758928665735 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SF3A2 0.0535527230852405 0.821101687607256 0.946029511818221 0.0882522678396481 0.711482754071075 0.895438659850091 -0.0268804521907038 0.935285427653295 0.423796326730737 0.0584787189194984 0.396915874540033 0.0926225306092382 partial_or_other True False False False True False False 1 cross_species_direction_conflict +SH3KBP1 0.0808757077671357 0.821126072919833 0.946029511818221 0.220044688600873 0.532833281304049 0.809783322169604 0.595202592214333 0.596454233907932 -0.114196082724975 0.895095917127387 0.481006509489357 0.636254007888489 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PSMC1 0.0555116438433239 0.822485451325472 0.946029511818221 -0.0299508010434792 0.902549457162765 0.968997068204645 -0.0463609107862552 0.917098540731119 0.802542906119098 0.0143756322204327 0.756181995332843 0.0273197270267665 partial_or_other False False False False True False False 1 insufficient_or_context_specific +OTUD4 0.0392253290351523 0.822496167190955 0.946029511818221 0.169811559200956 0.333829317493106 0.683680439096284 0.0415683906055269 0.909581560625457 0.203744268534224 0.395120665334236 0.245312659139751 0.343682300629958 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DCUN1D1 0.0329391943647524 0.822647732735153 0.946029511818221 -0.0900645575002389 0.541822863063494 0.813940850536852 0.361473028113899 0.574881936817143 0.725840702383161 0.106229062745688 1.08731373049706 0.0491567070782916 partial_or_other False False False False True False False 1 insufficient_or_context_specific +VPS8 0.0543076465151519 0.823517936212756 0.946029511818221 0.22995870037148 0.328802091709856 0.677655125241013 0.0332389321892514 0.936791653945909 -0.323046994038888 0.247262947735665 -0.289808061849637 0.33794760017863 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MTDH 0.0359409698040137 0.82372128264301 0.946029511818221 0.177912195607233 0.280773319671609 0.642821222582925 0.0853106082386065 1.0 0.177982656701194 0.541887269608551 -0.489949353016451 0.0521051564810123 -0.311966696315257 0.216607971100785 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MFAP3 0.0466365861713055 0.825074450850072 0.94621160456417 0.0608098539604564 0.773283647746646 0.921557797185125 0.467548008608906 0.128964160476572 -0.538253869879989 0.0515085319770978 -0.0707058612710824 0.82869638988022 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ECE1 0.0612961785994885 0.825596391094372 0.94621160456417 0.0507574965072936 0.854856566787329 0.955390667104966 0.928751437605011 0.7730327846650841 0.252204183578321 0.13959346091614 4.0 -0.695357163157515 0.0267567296902146 1.13039765419707 0.0023925920108839 0.435040491039551 0.118303071863233 reversed True False False True False False False 1 cross_species_direction_conflict +ALG14 0.0418975219939665 0.82565253340766 0.94621160456417 0.248023248402852 0.192994689505415 0.570885363891703 0.237054175602638 0.412466340475052 -0.0416105614972997 0.877545768120053 0.195443614105339 0.452924825790435 partial_or_other True False False False False False True 1 insufficient_or_context_specific +XPOT 0.0568111950726925 0.828469599881143 0.947127722307772 0.120219414342843 0.651456027245852 0.87009142766119 0.117789557222257 0.681022328767084 -0.103098872250712 0.649577614515961 0.014690684971545 0.957517615370191 partial_or_other True False False False False False True 1 insufficient_or_context_specific +WNT9A 0.106104445245724 0.8287143302405 0.947127722307772 0.195984901128116 0.698958495165765 0.889654761580003 0.309032454053468 0.699845491063796 -0.406723941724689 0.47763022575848 -0.0976914876712206 0.903117914154853 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ATF1 0.0344208347060941 0.829648913106351 0.947343365800488 0.0980594774916953 0.544461683655268 0.815113627216777 0.0796988307555928 0.792773476679991 0.164743320864169 0.452991885508476 0.244442151619762 0.296060213868884 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PPP2R1A 0.0373088972175338 0.830223714526758 0.947390862776809 -0.0427781627355064 0.80136542945403 0.930578113085751 0.140800429656181 1.0 0.0994592372623096 0.692046018169297 0.278421165709295 0.149767592123337 0.377880402971605 0.0761110811469107 partial_or_other False False False False True False False 1 insufficient_or_context_specific +SULT1B1 0.146393920946853 0.830779789401833 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0.834766045173179 0.948225126875272 0.124678618483742 0.70973477692539 0.894500642532718 0.158586764219473 0.617897316221769 -0.0483762217356087 0.861628794546181 0.110210542483864 0.703077273761247 partial_or_other True False False False False False True 1 insufficient_or_context_specific +INPP5B 0.039029931440611 0.835295031494965 0.948225126875272 0.0070806364929145 0.969842890207975 0.991737938845345 0.413884480994574 0.000736111750628266 2.0 0.620206614404577 0.0190928208577532 -0.44092342154467 0.0524014625971923 0.179283192859907 0.442967053498642 reversed True False False False False False True 1 insufficient_or_context_specific +FKBP3 0.0405615290748815 0.835789149677294 0.948302745551785 0.0419549021740162 0.830162242204907 0.943471792594123 0.01904152328421 1.0 0.334750183690643 0.312317440543541 -0.16357231591832 0.556757856958522 0.171177867772323 0.589007919062884 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMX1 0.0668461486210023 0.83580739366235 0.948302745551785 0.220876700695024 0.504094941569435 0.792706939691703 0.896909652626558 1.0 0.0987223603222222 0.757332032685163 -0.435219826831149 0.0792824084136033 -0.336497466508926 0.185209190772525 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SDHA 0.0362552622310618 0.836218798528198 0.948415305066142 0.0038614932531265 0.982491651847376 0.99451887511202 -0.191936938065681 0.645610418406442 1.03636270132777 0.0093810190300747 0.844425763262089 0.0282533534007889 partial_or_other True False False False True False False 1 cross_species_direction_conflict +TOR1B 0.0525353216761063 0.836774515953362 0.948637961928014 0.382793342328248 0.115988480667975 0.494328725999491 0.904848340079994 1.0 0.205685780874616 0.482135385466112 -0.156474634373733 0.512304686644997 0.049211146500883 0.868593021178236 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HNRNPC -0.0269736426814794 0.839227938945641 0.949157307903488 -0.0224652776365898 0.865102338114091 0.958391272020028 0.447076598291443 0.283615339988183 0.880073828479618 0.0150465658744709 1.32715042677106 0.0055519882210824 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NUP205 0.0495560977503118 0.840336739742066 0.949795581870218 0.0200755379877102 0.935229552176538 0.981623780880792 0.210865657991468 0.675926385250434 -0.827598163225974 0.0452267509547941 -0.616732505234506 0.158191320437955 partial_or_other True False False False False False True 1 insufficient_or_context_specific +UBE2D1 0.0696862173388335 0.841086092553874 0.950376610463724 0.165943487637937 0.635232012471473 0.861847932958146 0.0279989853043107 0.954530635502806 0.277606593209028 0.362568393658862 0.305605578513339 0.371897608816055 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NCKAP5L 0.0427843855835547 0.843037006873537 0.950376610463724 0.155535874925871 0.482431709943908 0.780666906162311 0.584163784707343 1.0 0.545032311301254 0.192174733359028 -1.09670526623767 0.0097873514076932 -0.551672954936412 0.189271208550537 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ZBTB49 0.0526156134963855 0.843511533678774 0.950376610463724 0.0711085699996784 0.790282510848294 0.927375594093834 0.323712242736943 0.463381410167706 -0.712875330546549 0.0574511026544237 -0.389163087809606 0.335958121424369 partial_or_other True False False False False False True 1 insufficient_or_context_specific +COPG2 0.0449918720041085 0.844078070373915 0.950376610463724 0.244420006031601 0.28881130954095 0.648310091921223 0.303765361635824 1.0 0.190292287095049 0.640049776292374 -0.0398965690511965 0.910925182383875 0.150395718043852 0.680376397065629 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CLSTN1 0.0415278355372873 0.844181616086981 0.950376610463724 0.0528940449672522 0.802008011171232 0.930781165449847 0.320539892079747 1.0 0.0552876775885527 0.860471158687774 -0.0766984386076966 0.74272938512306 -0.0214107610191439 0.937535796537767 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CALU 0.052574645334074 0.844352661255243 0.950376610463724 0.212240881823283 0.411944661794371 0.735291083225579 0.943364122428332 0.0382757462821866 -0.294884168737214 0.39594717990367 0.648479953691118 0.122645155039457 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EIF2B1 -0.0395272247232869 0.844442365162651 0.950376610463724 0.0248223632954781 0.902044579366813 0.968849101623073 -0.0643572430571692 0.896038916493911 0.651095976770719 0.0508494566160915 0.58673873371355 0.0977189891346483 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DDIT3 0.0559924088574874 0.845298892672155 0.950376610463724 0.0750881727602018 0.794299996632452 0.928063228447907 0.227849368543745 1.0 0.0513981071914324 0.936257534403958 -1.50489945708994 0.0066457954532248 -1.4535013498985 0.011334705867474 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CDC42EP5 0.0469084447949813 0.845665283445042 0.950376610463724 0.114476936567565 0.636416992778538 0.862000078223965 0.65131465526294 1.0 0.455180748354364 0.325017572953707 -0.490883674263476 0.195157978375258 -0.0357029259091119 0.943350111093624 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NSMCE1 0.0584376472834344 0.846110997618304 0.950376610463724 0.004289138599135 0.988788549275492 0.996718493722613 0.9670964890851671 1.0 0.105272073029537 0.848129791979594 0.513668834610278 0.139062992282621 0.618940907639815 0.120387622541497 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MINDY3 0.0351809330186978 0.846435788163329 0.950376610463724 0.0103563989382737 0.954437634938906 0.987410276805219 0.332258760835929 0.300332674814797 -0.0109632172348987 0.972168488880337 0.321295543601031 0.271131543691581 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PLEKHH3 0.0441421711329376 0.84733216913727 0.950376610463724 0.233325717967252 0.292105261045764 0.651509781962399 0.283443912084987 0.416461098839755 2.0 0.244305287595598 0.448095743546838 -0.50020618967552 0.0700313405959671 -0.255900902079922 0.375799990754193 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PFDN1 0.0441941457778718 0.84739149256318 0.950376610463724 0.0873047063761401 0.70675161680356 0.892997076377691 0.8063771994743091 1.0 0.337181799697965 0.268441806510668 -0.367610613873389 0.157111018792547 -0.030428814175424 0.927177905708643 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ADSS 0.0436752297848446 0.847817834427327 0.950376610463724 0.192570365080723 0.384027265143652 0.719298323474503 0.621005081305259 1.0 0.034730841622153 0.938047378605598 0.0186842831192647 0.95668527601144 0.0534151247414177 0.88580044934936 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TUBB4B -0.0581661118643758 0.848003901009129 0.950376610463724 0.204849548548022 0.518950686608479 0.800840369846825 0.424098105950315 0.0825452834283036 0.392894816436502 0.0708517177578466 0.816992922386817 0.0055480039049741 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GXYLT1 0.0513588838552955 0.849099263095989 0.950813880764208 0.100837193024491 0.70934244105481 0.894344099911235 0.494941054218147 0.0678138984205387 -0.464182927486827 0.054066111517189 0.03075812673132 0.917649081729215 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PIGF 0.0573318490361644 0.849528516157346 0.950813880764208 0.0913167727375254 0.762505364659025 0.916603852905611 0.705168942950742 0.167384990199243 0.0476335921798462 0.915958863949638 0.752802535130588 0.114848826022164 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HGSNAT 0.0338849211156552 0.85027235393079 0.950894201796838 -0.0879232331829387 0.620966000454458 0.85421549797896 0.085192571593989 0.842120288450274 0.744371509836053 0.019322906242395 0.829564081430042 0.0199428747374646 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PSPH 0.0518716702584755 0.851661847348552 0.951655796828666 0.0517863204181123 0.852079373538112 0.954408447466092 0.502989343866712 0.148416223019748 -0.681187152897007 0.0320352186128655 -0.178197809030295 0.609786120629478 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VDAC2 -0.0544222932500771 0.851803677328041 0.951655796828666 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0.886441913181475 0.962419156428199 0.231041992466989 0.561921011721646 0.823333352983166 0.0285646870048032 1.0 0.363423906783123 0.160281342942522 -0.311175954100588 0.163706175875264 0.0522479526825357 0.848856992637175 partial_or_other True False False False False False True 1 insufficient_or_context_specific +APOH -0.0481382359854505 0.886694999877899 0.962447394747698 0.235568550612616 0.493231659983763 0.786363265568912 -1.02864096264292 0.05333521876775 2.01786452687046 0.0017823666446357 0.989223564227538 0.0406267983897601 reversed False False False False True False False 1 insufficient_or_context_specific +BRSK1 0.0553646782070606 0.892957814881047 0.964683168885101 0.0758429978211912 0.855657334349161 0.955779743552523 0.0017553417118522 0.997530093382209 -1.02712141382613 0.0348550363218402 -1.02536607211428 0.0496938829356209 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPTLC1 0.0195887474997405 0.895508271010134 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insufficient_or_context_specific +EPSTI1 0.0366720023805662 0.89875099719345 0.966996040341054 0.181615221312751 0.520218946103116 0.801118945922776 0.460934175665567 0.727576365037144 0.0369086622354263 0.970762951952572 0.497842837900993 0.661091246293209 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HSPA4 0.0228568556994947 0.899657020058872 0.966996040341054 0.111259069119317 0.543308459604581 0.814576926513088 -0.225277706485972 0.541096566273747 1.07754176153843 0.0038510740420548 0.852264055052463 0.016700178162883 partial_or_other True False False False True False False 1 cross_species_direction_conflict +VPS26C 0.0217631350113907 0.900666564157483 0.96736903198115 0.0955743541996145 0.582039632181645 0.833470017167205 0.0332176565789186 0.940023552473003 -0.0387714488065454 0.908140678186485 -0.0055537922276267 0.988314184511743 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CBWD1 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-0.0569088632859598 0.844121901761758 0.950868579539813 0.826430215356266 1.0 0.393754114225134 0.230179873717039 0.474741349158314 0.0973048487417624 0.868495463383448 0.0150023143202489 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CTSA 0.0320021969465468 0.909419479339721 0.970491890524477 0.1312706987659 0.643723028313965 0.866007611230739 0.171811250093697 0.580906900835266 0.110604882428207 0.673524280748907 0.282416132521903 0.283776487103477 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PBX3 0.0249359263160682 0.912759474640038 0.97233510303033 0.266783197746958 0.239714195573864 0.606713331305531 0.706075967834238 0.251040801315648 -0.330388409014592 0.47763022575848 0.375687558819646 0.532746610330039 partial_or_other True False False False False False True 1 insufficient_or_context_specific +AP2M1 -0.030436635569417 0.912841972081515 0.97233510303033 -0.203898586790604 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0.643605944428588 0.121810942526137 0.129296454870236 0.709152901316051 0.772902399298824 0.0547258120835453 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CAPRIN2 0.0213393889674357 0.918143155752811 0.973181851556645 0.144233824683434 0.507997670504416 0.794701349116258 0.452522061252821 0.421192047821615 -0.346590917263312 0.411362867629254 0.105931143989509 0.857766077637751 partial_or_other True False False False False False True 1 insufficient_or_context_specific +EEF1AKMT1 -0.0270486655610517 0.918180890120414 0.973181851556645 0.0466337346947465 0.858518829778229 0.956914759994669 0.8200482323178041 1.0 0.730156524159172 0.150770190663553 0.274513853180464 0.471557917358272 1.00467037733964 0.0416447792621969 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PSAP 0.0194374694788533 0.919695596740447 0.973564434679608 -0.0774347551584392 0.683196115053188 0.882238818827245 0.75817809761064 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0.254520519376023 0.614121189200058 0.715918536080514 0.0507824577073524 0.970439055456537 0.0297616020955191 partial_or_other False False False False True False False 1 insufficient_or_context_specific +EIF3F -0.0207092090475691 0.930469597016468 0.978086221156897 0.204455120926929 0.393577127809539 0.725409980519913 0.0363864548427867 0.925059466657728 0.942128703182927 0.0038496969547946 0.978515158025714 0.0054925530669251 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GFM1 -0.0199075685578165 0.931021138148471 0.978373760980548 -0.0141980609489905 0.950830847660157 0.986917609553614 -0.0181951120809687 0.953538572668654 0.730236056687789 0.0048793464745672 0.712040944606821 0.008588523543753 partial_or_other False False False False True False False 1 insufficient_or_context_specific +NUP153 0.0131826554950971 0.931685208280699 0.978526115491437 -0.118659839712851 0.459100390203334 0.768296389248185 0.149746133025367 0.64913110973143 0.448280787603564 0.0768959910387627 0.598026920628931 0.0391567750557942 partial_or_other False False False False True False False 1 insufficient_or_context_specific +HNRNPM 0.0117008430499561 0.932171290674358 0.978803032017888 0.0202971482239954 0.882145023842369 0.962655003796147 0.0634099435309398 0.845155842907057 -0.237881369168533 0.298825502027285 -0.174471425637593 0.476015795629519 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NARS -0.0188909275585786 0.933533893593279 0.979846555715671 -0.131321070405686 0.559638910681665 0.82190396702977 0.136929889670923 0.778970330370053 0.672514594061134 0.057769058633131 0.809444483732057 0.042453334762292 partial_or_other False False False False True False False 1 insufficient_or_context_specific +OSBPL3 0.0295189764174041 0.933975133858702 0.980112261532669 0.53300036831565 0.177369656439681 0.560008622215954 0.862388138684232 0.0695964118856682 -0.931673724696215 0.028889583963682 -0.0692855860119822 0.89776139185557 reversed True False False False False False True 1 insufficient_or_context_specific +GPR176 0.0294949312383685 0.934378844749066 0.980163557958309 0.333948731883026 0.339121321995062 0.686946959803023 0.444493964763002 0.6762434357713659 2.0 4.00078312599263 0.0047273898173657 -3.03570095132232 0.0041095926989496 0.965082174670302 0.572716730394229 reversed True False False False False False True 1 insufficient_or_context_specific +MPLKIP 0.0184223945755185 0.934636809060645 0.980309692427196 0.0229812622170979 0.918628824814315 0.975930957742715 0.684970786117063 0.210809862297726 -0.0966151985938082 0.832516716400626 0.588355587523255 0.248220564305684 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CKAP4 0.0196547048843151 0.935824511389126 0.98049371749989 0.147165561907733 0.568155777604878 0.825129552905055 1.0764271753552 0.021866722114149 -0.690896962917044 0.0774466242472505 0.385530212438154 0.352956736180375 reversed True False False False False False True 1 insufficient_or_context_specific +TTC37 0.0130117342000336 0.936825242699795 0.981043634740153 0.187707170145806 0.232997295521366 0.602604162857471 0.0001077492690655 0.999592852268872 -0.619874147336768 0.0216618004320573 -0.619766398067702 0.0298131918658172 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ABHD12 0.0139426462083538 0.937278427787534 0.981165178685723 0.046481400403192 0.794775861208014 0.928199704380062 0.0116087745792465 0.969651685100975 -0.011785401246625 0.961004759139789 -0.0001766266673784 0.999577757834577 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GAPVD1 0.0089466259829942 0.94289369061841 0.982743640089234 0.106501158389908 0.390357175629471 0.722218665388488 0.255567676737813 0.274973819582601 0.0682248673321157 0.74815318481008 0.323792544069928 0.134670205512877 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NCAPG2 0.0173670023389716 0.94431068185605 0.983216460436018 0.322759555062337 0.19622082434697 0.571818786490563 0.299332901699869 1.0 1.52779597748031 0.0239973673244964 -2.7902034972058 0.0015027907744402 -1.26240751972549 0.122104384902603 reversed True False False False False False True 1 insufficient_or_context_specific +OPHN1 0.0144826926721317 0.94447635364104 0.983216460436018 0.112993144896225 0.586294539534805 0.835145405883496 0.265818693228132 0.614987229899015 -0.477972044705983 0.230395673374995 -0.21215335147785 0.66613947490803 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TGFBI -0.0429802090999665 0.945451906634403 0.983695730520834 0.121709076147319 0.84500160894338 0.951223689862907 1.02756704382157 1.0 0.234735800936521 0.533071517259791 0.558928807081371 0.0814634999037449 0.793664608017891 0.0280469397924125 partial_or_other False False False False True False False 1 insufficient_or_context_specific +FAM114A1 0.0112852327412632 0.947494516791994 0.98480479506693 0.0204588850544517 0.904672722921099 0.969884267885983 0.00250775493375521 1.0 0.144302432423987 0.599972823760722 -0.176875717826899 0.421919334472003 -0.0325732854029117 0.905903214090264 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SCAF4 0.0104631517764459 0.948314301004359 0.984984740237977 0.0526361042347728 0.744399595235642 0.909500945159707 0.111564632283669 0.686444942171429 -0.215778269453294 0.309591690045193 -0.104213637169625 0.668814490042089 partial_or_other True False False False False False True 1 insufficient_or_context_specific +STAU2 0.0126969444134636 0.948413986480325 0.984984740237977 0.0937806592579573 0.629008081758396 0.858472266510466 0.0215337090253911 0.97167108654619 -0.636784824914969 0.132495416901808 -0.615251115889578 0.186382510196144 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GNB1L 0.0157724305573901 0.948892773165605 0.985120542282947 0.140030853744349 0.618947326117052 0.853557418006095 0.638137872507969 0.484313473218342 -0.536242397531864 0.411727089956563 0.101895474976104 0.918625755000584 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NDRG2 0.017544095320187 0.949766638485784 0.985323392859674 -0.229201135876813 0.390605573232244 0.722269732670054 -1.04615881398124 0.0112239444835417 1.78813292014241 0.0009495760536071 0.741974106161164 0.0439127079938329 reversed False False False False True False False 1 insufficient_or_context_specific +OCRL 0.0151388060860725 0.951115184579379 0.98602199054023 0.0274792640297184 0.911399545034003 0.972564826811098 0.0212687004569588 1.0 0.117505537834236 0.768408825074034 -0.266508072998011 0.362845359333796 -0.149002535163776 0.659788869519024 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DVL2 0.0172292873297486 0.95206607218345 0.9860827708185 0.0452933181027656 0.87566940490495 0.960395245514428 0.669847413263095 0.0310071580014565 -0.832818585486894 0.0071779305864204 -0.162971172223799 0.587056969566655 reversed True False False False False False True 1 insufficient_or_context_specific +LRRC40 0.0092835954048596 0.952407643132194 0.986104723795651 0.170722880169557 0.286435693189925 0.64687121300967 0.0382845626334049 1.0 0.429416424661473 0.451053509040966 -0.589654645833943 0.183665342211174 -0.160238221172469 0.784906699367165 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TULP4 0.011107285506441 0.953150298930498 0.986111489229098 0.212680167498307 0.255544848837843 0.620376747482078 0.101878975794279 0.72189463408318 -0.277653654686636 0.20365798096274 -0.175774678892357 0.456219163158182 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GPR161 0.0234827275933759 0.953695312702792 0.986111489229098 0.466235781163899 0.256893691778096 0.621805194967499 0.448790518898392 0.450274854573042 -0.72971615207668 0.11817633015534 -0.280925633178288 0.637302107524846 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PRPF38A 0.0169139771131224 0.953795276378817 0.986111489229098 0.141715430322611 0.624090270240291 0.85594302057622 0.300621639926199 0.403880964912857 -0.0307405156224237 0.928895638729733 0.269881124303775 0.403456815229594 partial_or_other True False False False False False True 1 insufficient_or_context_specific +CAPZB 0.0092728568659735 0.955077156523609 0.986654931577523 -0.157394899919714 0.345918482341732 0.691178899947117 1.05074765359095 0.266428171260415 0.00112698965308 3.0 0.359108594332118 0.148757698730074 0.716445063308228 0.0062515815800947 1.07555365764035 0.0022877518871609 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PMPCB -0.0095365699487754 0.955629222420132 0.986654931577523 -0.0446600663551396 0.794998927262022 0.928199704380062 -0.206201127697478 0.526280348137406 0.688603300232721 0.0201145712360978 0.482402172535243 0.0910877900846935 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TRMT2A 0.0152609072525155 0.956568888937304 0.987091193808538 0.23364142539235 0.409329032268028 0.734857324041122 0.589117808195146 0.0131633823610537 2.0 0.14372642561707 0.634097347706747 -0.292665462344779 0.214976534815621 -0.14893903672771 0.57335662612511 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TIMMDC1 0.0138499096787436 0.957076144647479 0.987091193808538 0.262729714663217 0.302255869568145 0.659654231563018 0.0904742927797305 0.782041533307582 -0.166081907072102 0.490696263434701 -0.0756076142923713 0.791300978675096 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ADHFE1 -0.0261960243393867 0.957875217645313 0.987525295176175 -0.543406948816402 0.260598556759179 0.623334744509154 -0.287336453549034 0.299220245282979 1.31811728270125 0.0007735858136339 1.03078082915221 0.0033507820838639 partial_or_other False False False False True False False 1 insufficient_or_context_specific +TRAPPC8 0.0071047115018553 0.961515399293015 0.989460119715152 0.192889864986763 0.171984554085072 0.552927199156574 0.086208784811306 0.775857602909843 -0.122039794705378 0.593954844453591 -0.0358310098940716 0.897710141575316 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GYPC 0.0127930141170208 0.961532565663711 0.989460119715152 -0.0361228356579997 0.890809788239773 0.964781821824492 1.00084478256233 1.0 0.210887969764514 0.599633835023936 0.621514052907812 0.0522821276476549 0.832402022672326 0.0260063020234298 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PLXNA3 0.0135988950303983 0.961707554886646 0.989543744712329 0.343360557056934 0.228864101182951 0.600424738880655 0.752473999108041 0.299067506948881 -2.00686489365223 0.0098658967683015 -1.25439089454419 0.128794237013735 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PEX11A 0.018166385941727 0.961814093807047 0.989556928709296 -0.471387139460912 0.207026748511867 0.5799531910554 0.262861302107487 0.0209491264948839 2.0 -0.162613461195149 0.798577393174677 0.979252081810484 0.043471065065575 0.816638620615334 0.0977189891346483 partial_or_other False False False False True False False 1 insufficient_or_context_specific +INPP5A 0.0113712503886582 0.96298675338223 0.989894006954299 -0.0026298508475209 0.99143137849326 0.997572905187443 0.150606655869414 1.0 0.360062086920939 0.171213019822042 0.126217726904665 0.580326354529091 0.486279813825604 0.0563881481431773 partial_or_other False False False False True False False 1 insufficient_or_context_specific +AGFG1 0.0073969047140954 0.963569677527841 0.990205241905679 0.131552575787745 0.408303264313978 0.734801770489731 0.198189874337271 0.560983902319736 -0.626409295110834 0.0361108463858249 -0.428219420773563 0.150583734965583 partial_or_other True False False False False False True 1 insufficient_or_context_specific +THBS1 0.0182982919738636 0.96719674622558 0.991631772518489 -0.125567896451447 0.783088142420497 0.924823872729453 0.361613575688687 0.355650339468812 2.0 2.9185257359161 0.0001249977938437 -1.46124686164259 0.0039566153281876 1.45727887427351 0.0094564256215683 reversed False False False False True False False 1 insufficient_or_context_specific +GIGYF2 0.0047715685850441 0.970047450311673 0.992789439595521 0.0482279043593967 0.701676672798656 0.89138518967732 0.189388798007052 0.697716083849624 0.176049085917046 0.630654097711886 0.365437883924098 0.356851354907375 partial_or_other True False False False False False True 1 insufficient_or_context_specific +ARL5A 0.0097318069418637 0.97156510340968 0.993148421080372 0.340906178003157 0.197101212164646 0.57217338411722 0.225657689207028 0.5494642790669 -0.146309148455705 0.64314367972605 0.0793485407513227 0.827558411858842 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DACT3 0.0172651696171781 0.971727018015427 0.993148421080372 0.615319275481939 0.202732196001318 0.57668584531318 1.14356991960116 0.0025660399388253 -1.39827547944207 0.0010849898901959 -0.254705559840912 0.39268444795298 reversed True False False False False False True 1 insufficient_or_context_specific +COPS4 0.0078747240403179 0.972265777636553 0.993148421080372 0.0104597562460978 0.962962863932216 0.989935386867005 0.118492415443989 0.699843828596918 -0.0964343498563322 0.693565740264836 0.0220580655876565 0.940961636105127 partial_or_other True False False False False False True 1 insufficient_or_context_specific +DDX52 0.0073185901579758 0.974166778145354 0.99389126306238 0.0015939613608833 0.99400290845513 0.998542598236847 1.08872335463282 1.0 0.0858530311539294 0.826191364961233 -0.285555405565548 0.289703483041687 -0.199702374411618 0.51169744156602 partial_or_other True False False False False False True 1 insufficient_or_context_specific +IL15 0.0082995080497359 0.974216772251617 0.99389126306238 0.025450071383926 0.920949934797849 0.97652542797714 0.288328506621313 1.0 0.178560448168782 0.832879822570068 -0.0899922906625346 0.884397125471825 0.0885681575062477 0.906294801571847 partial_or_other True False False False False False True 1 insufficient_or_context_specific +BRI3 -0.0042434887543114 0.978212606390874 0.9958986381827 -0.0194537209521977 0.898130933099395 0.967796120806635 0.375745767188171 1.0 0.115684575110541 0.757693502074669 0.735583161795769 0.0188063214302107 0.851267736906311 0.01475632710262 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PAK1IP1 0.0083322133660928 0.978674171505697 0.996003335662695 0.2006659295711 0.555601631909465 0.820425458699318 -0.134138003834767 0.657805466866601 0.685987605888973 0.0110008762761375 0.551849602054206 0.0374926649626895 partial_or_other True False False False True False False 1 cross_species_direction_conflict +SLC25A1 0.0078869329290302 0.979476643113099 0.996040674920114 0.0150367850760257 0.962328769520203 0.989873931526713 0.129883587756419 1.0 -0.0805702146089234 0.873571778315485 0.937517803511246 0.0189222756810245 0.856947588902323 0.0340277104791189 partial_or_other True False False False True False False 1 cross_species_direction_conflict +MCM9 0.0042421862632242 0.979829257205771 0.996040674920114 0.1378416566763 0.422693441533115 0.744144334629103 0.194122536465381 0.576525859950077 -0.100380919176436 0.726436419844969 0.0937416172889451 0.775463541278702 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SPPL3 -0.004653156212902 0.980474591252581 0.996040674920114 0.129032317538946 0.48996476022389 0.784627322682213 0.316217160658189 0.37499248380668 0.362000713309301 0.204728781877924 0.67821787396749 0.0445073299398308 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DHX33 0.0073047956570713 0.981331487231318 0.996527637028783 0.161363306754003 0.634882915139631 0.861847932958146 0.0595685014903874 0.888756317097729 -0.15167800751728 0.608702142739624 -0.0921095060268922 0.790663895665047 partial_or_other True False False False False False True 1 insufficient_or_context_specific +YIPF1 0.0058001312146177 0.981776908602151 0.996788210503078 0.0684542233754645 0.777221820916044 0.922929913000972 1.1376053051537 1.0 0.0091061605254983 0.980581669633894 0.331208416009159 0.17171932312838 0.340314576534658 0.191950545752524 partial_or_other True False False False False False True 1 insufficient_or_context_specific +LIMS1 -0.0051587142262302 0.982655620319431 0.997088076507116 0.195531073978297 0.389891459674509 0.722218665388488 0.627396207817324 0.774926425577182 2.0 0.198695518861834 0.59721825707665 0.415009488787232 0.161885806336959 0.613705007649066 0.0634667610572241 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GABPB1 0.0033340736052064 0.982918172768509 0.997088076507116 0.0194645756651322 0.900177828404829 0.968057977213875 0.417985541656325 0.358113220795809 -0.427015474616508 0.238178461086442 -0.0090299329601833 0.986272547472679 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SDHC 0.0040946372246818 0.983203357159089 0.997088076507116 0.0490186915178656 0.80158847077102 0.930734749191733 0.0383335430961876 1.0 -0.046728630418178 0.936257534403958 1.11712072142809 0.0139385888003013 1.07039209100991 0.0225470605348611 partial_or_other True False False False True False False 1 cross_species_direction_conflict +TXNRD3 0.0049546872131712 0.983594082062461 0.997088076507116 0.083001077113278 0.743225353079748 0.909273715761109 0.0606383632143772 0.932564035076781 0.53270488856001 0.198005791923178 0.593343251774387 0.218726361577926 partial_or_other True False False False False False True 1 insufficient_or_context_specific +GORASP2 0.0043360518615765 0.985002686755372 0.997388466578742 0.166464314968222 0.457693500393775 0.76776776876263 0.403564127122572 1.0 -0.179232274837835 0.540716518593329 0.604614996189059 0.0216498041479773 0.425382721351224 0.0954444695151388 partial_or_other True False False False True False False 1 cross_species_direction_conflict +FADS3 0.0060128738207558 0.98540384918221 0.997388466578742 0.0303367269031327 0.927900850344703 0.979087152943213 0.343150281741667 1.0 0.101800612364845 0.787062660677285 -0.252062897701729 0.364360617196476 -0.150262285336884 0.63055773505291 partial_or_other True False False False False False True 1 insufficient_or_context_specific +PFDN5 -0.0055824771242872 0.986236183951469 0.997455570495466 -0.508021235070537 0.0881128192710404 0.468622105620855 0.542420613471754 1.0 0.124782759108115 0.743854376911001 0.659048512252874 0.0297827090668634 0.783831271360988 0.0218106199675799 partial_or_other False False False False True False False 1 insufficient_or_context_specific +INTS8 0.0035987506253833 0.9868212010223 0.997482898926486 0.158016046114201 0.449775855656049 0.763939182518913 0.124705650617197 0.734095496232438 -0.552669879770545 0.0585135033049198 -0.427964229153348 0.157176244147384 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MMADHC 0.0037717942156845 0.987899021369552 0.997622899917553 -0.279038955135249 0.251721562490658 0.618547340340987 0.620287365621079 0.328569953455011 2.0 0.268780973661515 0.366160303334199 0.228451170142823 0.351575656249653 0.497232143804338 0.0727601763196182 partial_or_other False False False False True False False 1 insufficient_or_context_specific +ARHGEF2 0.0028769498329833 0.988056593529642 0.997622899917553 0.193656401502741 0.316486757101085 0.668962398693343 0.424181720521796 1.0 0.431598125757818 0.187624295778179 -0.755716877594623 0.0194264664718473 -0.324118751836805 0.28948953379064 partial_or_other True False False False False False True 1 insufficient_or_context_specific +VARS 0.0045852403926762 0.988173923786491 0.997622899917553 0.141056497019413 0.713784685453974 0.895839656627142 0.0152187739640783 1.0 0.381756268769661 0.163184855008553 -0.893321724287907 0.0043411408218517 -0.511565455518246 0.0597900830324279 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TMX3 0.0021781512216754 0.988844994868676 0.997918701569822 0.0539605905469844 0.72722870658087 0.903365569206837 0.485746254406991 1.0 0.0967246875177288 0.751798143959638 -0.285523732089031 0.208589517138224 -0.188799044571302 0.441982445862338 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NUDT19 -0.0043943476898529 0.989616635878206 0.998150694622828 -0.133785775322429 0.6921281341474 0.886508412025749 -0.0418953203844974 0.955120450578508 1.0466114595877 0.0311736354191018 1.00471613920321 0.0556752012051446 partial_or_other False False False False True False False 1 insufficient_or_context_specific +CPSF2 0.0024298591201189 0.98972826257514 0.998150694622828 0.137010011627062 0.475790257370249 0.777735491146475 0.224671263013317 0.522860005609365 0.0651440488749184 0.827240988011121 0.289815311888236 0.338264327470241 partial_or_other True False False False False False True 1 insufficient_or_context_specific +MYNN 0.0023359472831214 0.992490181290562 0.998432182743722 0.104948064935294 0.708588889174387 0.893714190885578 0.486693258926335 0.171260636207483 -0.310764628115556 0.287259450148033 0.175928630810779 0.614546215840734 partial_or_other True False False False False False True 1 insufficient_or_context_specific +SELENOP -0.0038155011922335 0.992983122605052 0.998658392880943 -0.219102448799394 0.598013770723746 0.842517933186724 1.00347547952482 1.0 -0.291766246256796 0.615951598187487 1.16129244508776 0.0266940646991683 0.869526198830967 0.0856808862526311 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PML 0.0017863115606399 0.993650915114046 0.998802939052278 0.0537962077365144 0.812098904008032 0.934063202799411 0.233957753918752 0.340202438205098 -0.101044525934877 0.639924073242462 0.132913227983875 0.565888059038065 partial_or_other True False False False False False True 1 insufficient_or_context_specific +FAM120A -0.0013390351028148 0.994090922044251 0.998810782438303 0.222428345461231 0.212414609009871 0.585096123643677 0.2576200168342531 1.0 0.123657185214371 0.684990529144695 0.46770717547982 0.0534293367249514 0.59136436069419 0.0300317934143284 partial_or_other False False False False True False False 1 insufficient_or_context_specific +DNASE1L3 -0.0055574863392415 0.994626243153131 0.998810782438303 -0.322198967165547 0.684189961251808 0.882766419515653 -0.269196984543926 0.541887269608551 1.08197452614523 0.0108441398036465 0.812777541601307 0.0431932782663734 partial_or_other False False False False True False False 1 insufficient_or_context_specific +GNL3 0.0014409548843585 0.996093209852128 0.998868638976966 0.0711690799308153 0.816984766887388 0.936371599889798 0.240523464612621 0.425677061548084 -0.299321417294596 0.23035007020331 -0.0587979526819752 0.848111486219426 partial_or_other True False False False False False True 1 insufficient_or_context_specific +HMCN1 0.0022132622417415 0.996121594853719 0.998868638976966 0.476262002892831 0.272589444257374 0.636584683138544 0.554409055842211 1.0 0.230499470810127 0.511407241181487 -1.04867862297367 0.0051268112190904 -0.818179152163544 0.0215252001116873 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NAA30 0.0011270610110346 0.996125014187202 0.998868638976966 0.0484253562093246 0.839525246031544 0.94849732986635 0.261293830457403 0.460530280699928 -0.0046323067373113 0.989377741631593 0.256661523720092 0.411634074357948 partial_or_other True False False False False False True 1 insufficient_or_context_specific +NDUFV2 -0.0006893378600087 0.997090239915257 0.999489555942382 0.0030448292696006 0.987727850446312 0.996505556140675 0.332691296470271 1.0 0.455618306789417 0.121810942526137 0.623762049921049 0.021692364869705 1.07938035671047 0.0037504253762014 partial_or_other False False False False True False False 1 insufficient_or_context_specific +PPP2CB 0.0005244752572438 0.998110891464649 0.999523967578481 0.0301849024121195 0.890426956590126 0.964713393362605 0.283095119657624 0.00250122159015265 2.0 0.235844616754197 0.343732521035371 -0.0988297549520306 0.656406356518325 0.137014861802166 0.559111353371776 partial_or_other True False False False False False True 1 insufficient_or_context_specific +TUBB6 0.0005492322052247 0.998521305222467 0.999547722001849 0.0233007488478824 0.939052953459525 0.983643567603279 0.275385769776077 0.0744418059426887 2.0 1.61279595004186 0.0072076097656167 -1.23262775913301 0.0134065240993739 0.380168190908848 0.468358701141154 reversed True False False False False False True 1 insufficient_or_context_specific +LINC01099 -2.75805650643674 0.000106520775216 0.108955765289858 -1.48421697214571 0.0680557439206604 0.43786261079484 False False False False False False False 0 insufficient_or_context_specific +MPPED1 -2.74223699671338 0.0003889006350628 0.128042361093427 -0.189833626255879 0.843062081648917 0.950560599962545 False False False False False False False 0 insufficient_or_context_specific +ZNF160 -1.11951812286192 0.0005622225248395 0.138619773467801 -0.585318506573306 0.11667645195833 0.495722325865612 False False False False False False False 0 insufficient_or_context_specific +AC004053.1 -3.57600817141809 0.0007077822930413 0.14370702788329 -1.09960044355396 0.33832406596045 0.686399978556962 False False False False False False False 0 insufficient_or_context_specific +SNCA -2.11110881243139 0.0007469704027564 0.146046546524121 -0.751513116503248 0.270568564667695 0.634531964851516 False False False False False False False 0 insufficient_or_context_specific +PZP -2.92517671950681 0.0007931787472601 0.146549458248405 -1.39090517240058 0.150100645347484 0.533583468169136 -1.06992103868278 0.0326237979384006 1.33332549783599 0.009776171573976 0.263404459153213 0.566595929976334 reversed False False False False False False False 0 insufficient_or_context_specific +RGS5 -1.33736323657161 0.0008597368557624 0.14718914218163 -0.560568161962398 0.206998335698711 0.5799531910554 -0.274805987379455 0.475472325092495 0.289479396240479 0.368004800585351 0.0146734088610241 0.971660897253608 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL139807.1 1.43013604749359 0.000919553774092 0.148000497085406 0.878392068297317 0.0517155553583531 0.41177438421832 0.0684796077703057 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF790 0.894645975070548 0.0012849755882733 0.164558653805348 0.557821642425358 0.0516006012858921 0.411222531681 0.0395798541422664 1.0 True False False False False False False 0 insufficient_or_context_specific +DOPEY2 -0.852609725779186 0.0014510765206897 0.166011993302809 -0.523341173897094 0.0815319925175059 0.461068439742811 False False False False False False False 0 insufficient_or_context_specific +ZNF804A -1.68160168880189 0.0014796655641105 0.166011993302809 -0.567668133758569 0.332244527105259 0.681398157959853 False False False False False False False 0 insufficient_or_context_specific +AC026316.5 1.640322303328 0.0015093077229434 0.166011993302809 0.900823904113008 0.0838185633470342 0.464779732481256 0.3056244196986599 0.210417378948359 2.0 True False False False False False False 0 insufficient_or_context_specific +GDNF-AS1 1.41914075299095 0.0015112997243746 0.166011993302809 0.865639558889169 0.0583950774296865 0.42715254026823 0.0506794412685386 1.0 True False False False False False False 0 insufficient_or_context_specific +LYPD6B -1.96668005395109 0.0016400406667965 0.173155493600382 -1.18028444626039 0.0864651911969168 0.467677448123587 False False False False False False False 0 insufficient_or_context_specific +MSR1 -2.04592186338496 0.0017747459764994 0.175448047823497 0.194823373911977 0.793777375608567 0.928063228447907 -0.0521142828814513 0.935285427653295 -0.362153646902476 0.391767837507871 -0.414267929783927 0.368061746006152 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAR2 -1.70970091867262 0.0018111408102411 0.177055784023389 0.0417582168737565 0.953303273113957 0.987149466215884 False False False False False False False 0 insufficient_or_context_specific +ACER2 1.11250291975178 0.0019005159563071 0.179665930369822 0.356696813358599 0.304021357713511 0.661341495477036 0.756207352013744 0.644458821794796 2.0 -0.551560107609907 0.161663076605953 0.0554003146396118 0.890844694725049 -0.496159792970295 0.17394769299212 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL442647.1 -1.16060765300806 0.0019741668530113 0.181311174473953 -0.719973149701064 0.0716118610619514 0.446327053773367 False False False False False False False 0 insufficient_or_context_specific +MADD -0.649593249256398 0.0022555447499294 0.195098477914886 -0.452218512570422 0.0526738450837568 0.415925242477334 -0.361053670279914 0.365517268684563 0.0330300195376204 0.931942990277106 -0.328023650742294 0.36167345898242 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FMO2 1.50724149036145 0.0032233328908956 0.212953915711243 0.470269797636098 0.374456803198003 0.712838905321506 0.0884132108866015 1.0 -0.587883504423465 0.450742324667811 1.0907420641779 0.0998943337090244 0.502858559754436 0.460839663030999 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF175 0.859935085242686 0.0032874834846466 0.212953915711243 0.557333548931098 0.0502849451045953 0.405592093535716 0.31603269406742 0.0203784392588272 2.0 True False False False False False False 0 insufficient_or_context_specific +GPC5 -1.41696947345033 0.0035080312205401 0.21424167471499 -0.507614082861531 0.313648226372419 0.666297379082494 False False False False False False False 0 insufficient_or_context_specific +THOP1 -0.979974748615698 0.003536864208309 0.21424167471499 -0.531120716044566 0.131573847151451 0.517896578143491 0.326457005816062 0.375932411601437 -0.221002675893126 0.455195761149401 0.105454329922936 0.777001512008736 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHTF2 0.669551459517391 0.0038173269253651 0.21424167471499 0.450845863658312 0.0621219904598942 0.431813959784778 0.0758967268851719 1.0 -0.0432338886688308 0.936661485901735 -0.103006814408259 0.781364789125753 -0.14624070307709 0.731664018703269 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ALS2 0.449558051470435 0.0038830101689013 0.21424167471499 0.217837277072381 0.196945870481406 0.571879675616801 0.210215818221469 0.0659383762428057 2.0 -0.156315605366238 0.726420342711344 0.659117257836016 0.0574511026544237 0.502801652469778 0.157176244147384 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC138123.1 1.77714497535495 0.0040112480862212 0.21424167471499 0.708098669246954 0.224446526774575 0.596340158056908 0.0519079923849553 1.0 True False False False False False False 0 insufficient_or_context_specific +FAM171A1 -0.807830362696496 0.0041517824449245 0.21424167471499 -0.437590415946543 0.150526111062068 0.533583468169136 0.427291889843932 1.0 0.299493559978342 0.46104734065596 -0.264878673947597 0.406138585886858 0.0346148860307452 0.934929016521663 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STEAP1B 1.19222902723901 0.0042207111518012 0.21424167471499 0.62622889879244 0.139184862603444 0.524072738828147 True False False False False False False 0 insufficient_or_context_specific +CADM2 -1.89099469823128 0.0047177466930468 0.221799407601324 -1.01130375084205 0.145802614002065 0.532658823056677 False False False False False False False 0 insufficient_or_context_specific +LRRC4B -1.07865146368733 0.0051277570806014 0.227474198558781 -0.524196037849405 0.221069890589685 0.592851385533627 False False False False False False False 0 insufficient_or_context_specific +SYPL1 0.697284047263231 0.0052850452966398 0.229265285907992 0.332427568015579 0.192854031011042 0.570885363891703 0.373514176846895 1.0 True False False False False False False 0 insufficient_or_context_specific +POLR2H -0.686255756210547 0.0053199648231472 0.229265285907992 -0.457431451296938 0.0684115610717497 0.438244764077482 0.130511651666365 0.764002699388411 -0.209821719674014 0.508807794493669 -0.0793100680076487 0.84054362299764 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARL17B 2.09106750797229 0.0055648722443278 0.229265285907992 1.22078148766821 0.0957682257777469 0.47569521889622 0.145751177810133 1.0 True False False False False False False 0 insufficient_or_context_specific +PXDN -0.810355836026556 0.0057379204574799 0.231589375580443 -0.590924937013215 0.0623556087112818 0.431813959784778 0.297211574733997 1.0 0.200086025151293 0.546281332495745 0.0294485267854742 0.92629312930771 0.229534551936768 0.422316311212208 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF347 -0.745173970097586 0.0060668257746186 0.235490979883912 -0.531576256544077 0.067618694775728 0.43786261079484 0.8295981003159291 1.0 False False False False False False False 0 insufficient_or_context_specific +LRRC7 1.27326085771973 0.0061780800326986 0.236788351127249 0.54741695215034 0.251250177395847 0.618056703854929 0.236230638908912 0.133380496583626 2.0 True False False False False False False 0 insufficient_or_context_specific +AC053527.1 0.852082020491924 0.0064384316256642 0.237387459486941 0.460187468400495 0.165190880969858 0.545367517598424 0.0460547054553642 1.0 True False False False False False False 0 insufficient_or_context_specific +KIRREL3 1.2192587612151 0.0064497887839916 0.237387459486941 0.667197865167465 0.129734343290374 0.514744530800362 0.0297883831772198 1.0 True False False False False False False 0 insufficient_or_context_specific +BTBD8 0.939226613546512 0.0066028965911054 0.237387459486941 0.595106359331869 0.0857832116957178 0.467503293000484 0.0785785138680428 1.0 -0.316882588967756 0.628807273711293 0.0245259079019173 0.967064446935449 -0.292356681065839 0.610436112254483 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CALCOCO2 0.66405869335362 0.0068353626119548 0.240253653298676 0.404469813437073 0.113860618108548 0.4924007041452 0.458243212686253 0.3905164039278859 0.110137764947599 3.0 True False False False False False False 0 insufficient_or_context_specific +UBE2B 0.654934902513338 0.0071357178899692 0.240995195720413 0.416287060969632 0.106942306898398 0.483261130274234 0.118758477901011 0.149857932912496 2.0 -0.203550967584472 0.47429094015097 0.504851229010422 0.0450696241691756 0.301300261425951 0.223400086632128 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HIF1A-AS2 2.352872259137 0.0071473232199609 0.240995195720413 1.02641989920038 0.225905152913973 0.598493814456385 0.109768749485616 1.0 True False False False False False False 0 insufficient_or_context_specific +CARMIL1 1.11939513239207 0.0072070419621406 0.240995195720413 0.803783949620683 0.0608312509658068 0.429268745755419 0.3803078128521 0.647116374552549 0.372559066112028 3.0 -0.451596554191004 0.269965700040567 0.0236713801228773 0.954185055573644 -0.427925174068126 0.252996885998472 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GAS1RR 1.54034900810767 0.0076042735036512 0.245792082974862 0.90324466320378 0.124005274334401 0.506117936752985 0.669852138528785 0.0727766618513376 2.0 True False False False False False False 0 insufficient_or_context_specific +VPS26A 0.547455672203456 0.0078284345229204 0.246996184097737 0.263273874520574 0.187758111634506 0.56929178900529 -0.0925086783126279 0.829010029691934 0.619183628204886 0.0463356084844699 0.526674949892259 0.101160881693041 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF33B -0.722057740658816 0.0080046962716225 0.249302605415312 -0.459433063860622 0.107456584302592 0.48374623385926 False False False False False False False 0 insufficient_or_context_specific +PIK3C2B -1.01264698732578 0.0081486883352391 0.252298684584913 -0.702815850591928 0.0730483108819923 0.450493029376212 -0.0691552119241085 0.914881531455775 -0.399042573156081 0.34071478079604 -0.468197785080189 0.319843724086639 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KDELR3 -0.953179936714833 0.0084376536307651 0.256728377618497 -0.531561170661566 0.164096445260305 0.544850245278 1.60871969446332 0.0254489527712211 -1.78036968409256 0.0093204679616982 -0.171649989629237 0.826338772451962 reversed False False False False False False False 0 insufficient_or_context_specific +SOGA1 -0.438645970557831 0.0089374333700489 0.258484471839641 -0.317349612619784 0.0770749361698448 0.455668688469891 0.45239807708914 1.0 0.013242679190193 0.97100168852273 -0.556134276954572 0.0407005480300188 -0.542891597764379 0.0530617583926483 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC5A6 -1.14194058378371 0.0090254683727393 0.258484471839641 -0.821628008324205 0.0708294947042379 0.443801226075734 0.239270103191094 0.661386573767127 -0.050575880100739 0.912465925978508 0.188694223090355 0.699307840213037 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC131025.2 1.13192618596901 0.0091889793843138 0.259558601898396 0.430772952520527 0.335566400738251 0.684461073909613 True False False False False False False 0 insufficient_or_context_specific +TXN 0.687075119419025 0.009346330381542 0.259601690244713 0.514424587084055 0.0555892252473028 0.421331649096072 0.350316379338027 1.0 True False False False False False False 0 insufficient_or_context_specific +FGFR4 -1.19561861107975 0.009346708490791 0.259601690244713 -0.731489754052502 0.140725912486129 0.526401063874107 -0.45306713939421 0.218973840370977 0.142723526766526 0.667891315813048 -0.310343612627684 0.359428826668445 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00630 0.485947825066572 0.0095771239750373 0.263321028459492 0.317876472469707 0.105412074959551 0.482830329046451 True False False False False False False 0 insufficient_or_context_specific +CTCF -0.404526413386584 0.0102186383410283 0.269890529140342 -0.253336785654878 0.120129088634824 0.500999836515407 0.047819074203825 0.869015643979454 0.0089216430864785 0.969912171137823 0.0567407172903036 0.812821134876742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF2B5 -0.641210544407947 0.010381069053986 0.269958933674839 -0.378187738221074 0.133050744863205 0.519212049578983 -0.0695182237366701 0.82842998794592 -0.176824581199776 0.439538862002694 -0.246342804936446 0.306606581691307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKRA2 0.698872317977846 0.0107671111592469 0.274073458004984 0.47628562784489 0.0903793908578119 0.47215517500088 0.251944866475403 0.0486776211804527 2.0 -0.0678894668494712 0.84254452723701 -0.267858603689022 0.254063272945495 -0.335748070538493 0.191413802693045 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRPL13 0.834736865822485 0.0114109621668527 0.280178926878211 0.419021361110364 0.195890369605611 0.571700325195908 0.7734564522729019 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF213 0.885002161333263 0.0115165536419997 0.280851197393928 0.631608792279545 0.0834993359575706 0.464779732481256 True False False False False False False 0 insufficient_or_context_specific +FBXL19 -0.63621108098613 0.0115911071080137 0.280851197393928 -0.428873284342619 0.0920520620197021 0.472460751419842 0.0231322154318567 1.0 0.147824221488776 0.621154857208238 -1.04767548596216 0.0021937564618565 -0.899851264473388 0.0066929447478196 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL136164.2 0.7215784907277 0.0116602807815319 0.280851197393928 0.503232488847226 0.087523903574435 0.468622105620855 0.0502119470260948 1.0 True False False False False False False 0 insufficient_or_context_specific +TMEM161A -0.700190102217423 0.011700688309675 0.280851197393928 -0.518795114459247 0.0742350695793098 0.452862231765951 -0.119553274718208 0.677036261404006 -0.600105393573652 0.0184996676408861 -0.71965866829186 0.012540209536432 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPRJ -0.696442062667401 0.0117733768873477 0.280851197393928 -0.456930815106007 0.0980862749588087 0.478125555523304 0.0740342296767675 0.377437366618675 2.0 0.136825612720838 0.649482575198712 -0.0509058972853451 0.84347527882395 0.0859197154354926 0.754912044658967 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFYC -0.347680397434731 0.0117897565426588 0.280851197393928 -0.206431186512695 0.15108940623972 0.533690850143514 -0.353346093853913 0.314379091945882 -0.0952494177946432 0.767157356083017 -0.448595511648557 0.163565371504678 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC058822.1 0.834554035835025 0.0118107531391271 0.280851197393928 0.582793554499086 0.0781926426389876 0.457322349441485 0.100718762170506 0.0962750854899376 2.0 True False False False False False False 0 insufficient_or_context_specific +DDX54 -0.763021636576907 0.0118747874855728 0.281107637382686 -0.56687004057568 0.076036154706619 0.454582718735293 0.0953697393462456 0.774462607140807 -0.0105838246771456 0.970527405508542 0.0847859146691 0.769141925766335 partial_or_other False False False False False False False 0 insufficient_or_context_specific +JMY 0.563442613130717 0.0123139426433279 0.287634085018266 0.311686984398666 0.17384397545064 0.555690188558237 0.0257427477268291 1.0 -0.104828088279658 0.722741994461569 -0.320115121347494 0.163552133970238 -0.424943209627152 0.0863376956858805 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GPC4 1.05837184118209 0.0124287906361291 0.287770113018094 0.600347615788486 0.152561833761807 0.535993857546643 0.445728613250865 0.05770355448008901 2.0 -0.362287281693811 0.191433240261074 0.507412342182887 0.0503267769833071 0.145125060489075 0.585105838318253 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MST1 -1.54733075492759 0.0125453856032056 0.288661754680313 -1.22383669691436 0.0565612917147651 0.424397390412969 1.0119504731896 1.0 -1.08649445960742 0.0084779404616682 0.88423544385862 0.0170123406083983 -0.202259015748795 0.56131520805434 reversed False False False False False False False 0 insufficient_or_context_specific +TRMT1 -0.749107101215741 0.0128999432112743 0.29096528436151 -0.590534463732638 0.0540763898354842 0.419081294430039 -0.0700967170758328 0.85471421234687 -0.0008980263055305 0.997861089730202 -0.0709947433813634 0.822541066245188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLIS2 -0.897256177081473 0.0129143031986008 0.29096528436151 -0.599028186155891 0.115463353016567 0.493786316225751 0.329457657030739 0.342368947167019 -0.242749654207715 0.404910884834243 0.0867080028230232 0.805998221009205 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AGAP3 -0.532205474700686 0.0129747992621148 0.29096528436151 -0.419125015106694 0.0610278828735446 0.429268745755419 0.0626066227824058 0.83809321424773 -0.200028906330406 0.353596939059503 -0.137422283548001 0.563883950757715 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC090115.1 0.960402733766409 0.0129801713330433 0.29096528436151 0.45336073849832 0.249631026134192 0.615795414468412 True False False False False False False 0 insufficient_or_context_specific +TEAD4 -0.798511375345233 0.013260569623696 0.292253024645663 -0.48771132974693 0.142433445968766 0.528011532230573 -0.477134642826419 0.571861546955933 0.501561331859211 0.41249890567654 0.0244266890327912 0.976724499605269 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NT5C3A 0.54668763573785 0.0132686380266098 0.292253024645663 0.369757858530877 0.102992392261998 0.479239170340314 0.251195708414743 0.0814406221811838 2.0 True False False False False False False 0 insufficient_or_context_specific +AC058791.1 1.4408271302933 0.0133146175626685 0.292253024645663 0.971900763623058 0.0931572071499849 0.472709733823144 0.0369005848365205 1.0 True False False False False False False 0 insufficient_or_context_specific +NR2F2-AS1 0.650667216036417 0.0133803555297769 0.292253024645663 0.515866051257343 0.0554414023910389 0.421331649096072 0.158478524559742 0.167786130486133 2.0 True False False False False False False 0 insufficient_or_context_specific +MTHFR -0.594312378064395 0.0136103768774912 0.292253024645663 -0.49393465552306 0.0508095205736726 0.408254884487698 1.08831167459562 1.0 0.537508748955545 0.108146042994137 -0.985772941197204 0.0066350390024188 -0.448264192241659 0.156173792856801 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SAMD9 0.995304422559512 0.0137618558609666 0.294086988383279 0.594658411813422 0.145048779231666 0.532658823056677 0.0218873187207084 1.0 True False False False False False False 0 insufficient_or_context_specific +KANK2 -0.604874449279772 0.0138977146833244 0.294366420705352 -0.363115127663346 0.17976383322843 0.562759923872656 0.6136391158239979 1.0 0.218432940712006 0.351962483169755 -0.174395179917765 0.385848950412737 0.0440377607942406 0.856435874168073 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYCBP2 0.344410382845424 0.0140124568398531 0.294366420705352 0.244761786571712 0.094088422134563 0.474102577239623 0.122495605758485 1.0 -0.0362073819252133 0.914881531455775 -0.389560368339313 0.0956349353141034 -0.425767750264526 0.0866519301190438 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF827 0.677203441697614 0.0140274788159188 0.294366420705352 0.313898376330234 0.253458777740933 0.618991529980024 0.260263924666796 0.188679045144793 0.0704802827852167 3.0 True False False False False False False 0 insufficient_or_context_specific +AP000311.1 0.845202893277231 0.01417497239937 0.294889624750959 0.487361294914054 0.15269560782017 0.536135759017411 0.0289873998057056 1.0 True False False False False False False 0 insufficient_or_context_specific +DAP3 -0.447260563052744 0.0141886654076044 0.294889624750959 -0.350556410255067 0.066354506428293 0.436220970653747 -0.0951392605974307 0.731556142006226 0.0739720883120939 0.741582379224582 -0.0211671722853368 0.9355391200702 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIF1C -0.711661034648992 0.0143215417718756 0.295989240927797 -0.572405281596803 0.0593218064108685 0.428473540531152 0.536706906741592 1.50704937839941 2.0 -0.317822378425197 0.264681847750542 0.107283644101474 0.680277303557503 -0.210538734323723 0.420940023510473 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL513550.1 0.847181561721772 0.0143537120055912 0.295989240927797 0.632000120797311 0.065269287714676 0.435533238803682 True False False False False False False 0 insufficient_or_context_specific +CPSF1 -0.76835541148984 0.0145328985521607 0.297043416491418 -0.534684527593239 0.098162114793299 0.478125555523304 0.101407072631614 0.715407116185129 -0.332134204819237 0.124631191749373 -0.230727132187622 0.310554350779638 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNTRL 0.405506801222381 0.0146820358685263 0.297043416491418 0.311058463427537 0.0670216479498649 0.436862290339161 -0.0043463522953205 0.992788933773383 -0.572127700560428 0.0682981413448484 -0.576474052855749 0.0834496118422025 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DUSP18 0.82794982909824 0.0147765798996477 0.297043416491418 0.633282104619133 0.0670837422401141 0.436934084251157 True False False False False False False 0 insufficient_or_context_specific +ARNT2 -0.945096537922278 0.0148209273295749 0.297043416491418 -0.594256477447395 0.138084665186722 0.523810858054217 0.398244296443141 1.33955692908244 2.0 False False False False False False False 0 insufficient_or_context_specific +PITPNM2 -0.714286349002036 0.0150940793310332 0.297043416491418 -0.519786149573148 0.0858177066686335 0.467503293000484 -0.127152693381262 0.639417458018041 0.268839144061561 0.20252115111264 0.1416864506803 0.542990362101498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTNND2 1.5905371235646 0.0154247629459579 0.297043416491418 1.22175056703687 0.0573834198126596 0.424455207563489 1.698061815302 1.0 True False False False False False False 0 insufficient_or_context_specific +DYNC1H1 -0.359192617093781 0.0154458075065153 0.297043416491418 -0.244809867488194 0.125131866138851 0.507546001803299 0.246022375427069 0.419191636639268 2.0 0.466127569108435 0.0863826925477337 -0.123662775303167 0.612521743034383 0.342464793805268 0.172707733363931 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPART 0.500747948375733 0.015488767253869 0.29732800848427 0.324226664257692 0.137312838763673 0.523810858054217 True False False False False False False 0 insufficient_or_context_specific +C1QTNF7 0.979637354463531 0.0156354627434758 0.298027091192993 0.51354709963911 0.192452774510716 0.570885363891703 0.7265045178211621 1.0 -0.224684702007751 0.745995021322483 0.349677162454256 0.484087042604894 0.124992460446505 0.839727641947104 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CAPS2 0.584948525625214 0.0156566788617433 0.298027091192993 0.29358463596532 0.222917520438951 0.593969140017564 0.0530722629989704 1.0 True False False False False False False 0 insufficient_or_context_specific +LINC02319 -2.47206494935434 0.015813791540417 0.298679805158717 -1.94857577492695 0.0595729784106631 0.428473540531152 False False False False False False False 0 insufficient_or_context_specific +SPATA7 0.434076784499082 0.015919618264125 0.29965954108556 0.238715149145287 0.203644298679356 0.577025563405608 True False False False False False False 0 insufficient_or_context_specific +PHC3 0.413193564974667 0.0162315653528185 0.299692671530782 0.226428890936267 0.213309388937517 0.586184416554478 -0.236175091698533 0.480263155830792 -0.193321284517843 0.491478961284284 -0.429496376216375 0.146694208066431 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM20C -0.87602985302791 0.016432180746997 0.299692671530782 -0.669676932239429 0.0809414687719053 0.461068439742811 0.4570995639878929 1.0 -0.32474179349621 0.353814130855971 0.136020501681091 0.660525809086034 -0.188721291815119 0.564414441658696 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EZH1 0.540312349676222 0.0165908780809342 0.299692671530782 0.22633566365904 0.313921574454231 0.666609811562304 0.0901862383647833 1.0 -0.118886488269846 0.706776681862378 0.124012360919102 0.617950902649055 0.0051258726492555 0.987188266635384 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SH2B1 -0.708319319987159 0.0167130866506991 0.299692671530782 -0.547362678673436 0.0782895318774153 0.457322349441485 0.3254825522669361 1.0 -0.34418495663848 0.119568514822068 -0.553132648753941 0.0145816171561453 -0.897317605392421 0.0029653352383686 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MDGA2 -1.87518121788359 0.0168751014012052 0.299692671530782 -0.430538163425044 0.60964439626753 0.848013066172034 False False False False False False False 0 insufficient_or_context_specific +SLC27A5 -0.94709528460322 0.0169143865134512 0.299692671530782 -0.733387169941685 0.0749894330856367 0.452862231765951 0.771665685276718 0.294558411269447 2.0 -1.10442956921186 0.0545417470452315 1.51540634447836 0.010856353893885 0.410976775266498 0.425895928621757 reversed False False False False False False False 0 insufficient_or_context_specific +AP001347.1 0.715726940731556 0.0171746430023221 0.301624059184282 0.210266532609525 0.520140821628031 0.801118945922776 0.382041282326228 0.0936390630548126 2.0 True False False False False False False 0 insufficient_or_context_specific +CHFR -0.453142409689577 0.0174008647334016 0.304601890210076 -0.355679756301379 0.0732881475630382 0.451181493860383 -0.0657060882340698 0.854029741628969 -0.923764323950752 0.0048240084550877 -0.989470412184821 0.005441102035835 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAF1 0.874630306412563 0.0174532084296699 0.304601890210076 0.611784285893692 0.0974364431133668 0.478125555523304 0.843324682162705 0.84553288719982 0.0690934471446767 3.0 True False False False False False False 0 insufficient_or_context_specific +TC2N 0.90445627367507 0.0175207964729264 0.304839080101775 0.46688940376086 0.19084113677877 0.570147346380944 0.542326083352762 0.122707154982864 0.0484167771348751 3.0 -0.445327794735479 0.438853076644795 0.122734862427787 0.80877700836619 -0.322592932307692 0.536588622562443 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DNMT3A -0.557955899599692 0.017570671722101 0.304839080101775 -0.443708839915227 0.0667072001744637 0.436862290339161 1.32838438215873 1.0 0.177077747217496 0.521218168225128 -0.55539940626593 0.0264819574183372 -0.378321659048433 0.121606411452588 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SF3A3 -0.64238092491044 0.0176541138408628 0.304940639395205 -0.448844413338922 0.114067756520529 0.4924007041452 0.6655252498460601 0.7310549866779749 2.0 0.130482486950906 0.702415242790261 0.177487798626566 0.491376046560334 0.307970285577472 0.267419981061261 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPECC1 1.37846557811007 0.0177494939485783 0.305708249770129 -0.67079170465093 0.212750181679156 0.585257013592634 0.3803147963279311 1.0 1.29711774029592 0.0788764174420211 -1.64323349549602 0.0169868203212137 -0.3461157552001 0.677984706224116 reversed False False False False False False False 0 insufficient_or_context_specific +USP42 -0.404309966279224 0.0179508937772925 0.307150938068899 -0.191230178391656 0.301878269791567 0.65922243713362 0.275517435827021 1.0 0.0458656063249995 0.919058541659912 -0.163344576202665 0.592366637875902 -0.117478969877665 0.739564849239821 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTSL 0.847853805371114 0.0179763276012349 0.307150938068899 0.317429288003848 0.40014237822129 0.729997628255253 0.693787451149754 0.7153742271686171 2.0 -0.220049676730768 0.569782955767888 0.486387052588419 0.127284477362188 0.266337375857651 0.420098571857211 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ACADVL -0.989907129031227 0.0180496068638428 0.307150938068899 -0.6736767291271 0.119504063409747 0.500287034686802 0.5516597162046469 1.0 -0.48225215201525 0.15242107689691 0.745849173094265 0.0236721815132985 0.263597021079015 0.395404895046057 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APBA2 1.62140081211456 0.0183484672127324 0.308385251700923 1.19605091232661 0.0555237810593147 0.421331649096072 0.025004710424462 1.0 True False False False False False False 0 insufficient_or_context_specific +BAHCC1 -0.519395783237255 0.0184235536049217 0.308385251700923 -0.389127476937043 0.0964453793688934 0.476718312442311 0.910552969232991 0.000469110614792254 2.0 0.0090236135396407 0.981117342485003 -0.245558549652003 0.33669999347599 -0.236534936112362 0.395188806077642 partial_or_other False False False False False False False 0 insufficient_or_context_specific +E2F4 -0.607530763450771 0.018539852588323 0.308385251700923 -0.458898947871518 0.0871637735803702 0.468303538747472 0.0297872094426161 0.947515172143523 -0.290041690581817 0.332500931370495 -0.260254481139201 0.414858197895213 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC117 0.733338730469335 0.0187674273028782 0.309473467285879 0.573734692509214 0.0693199702114874 0.441104921144217 0.0269265804444973 1.0 -0.0957169125450566 0.843634970961798 -0.192272159491548 0.578309052375559 -0.287989072036604 0.427455556149829 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GRAMD2B 0.578095052107567 0.0188474559068782 0.309473467285879 0.396828244999655 0.121463989460005 0.503485437181972 0.763613167013516 0.452150800383231 2.0 True False False False False False False 0 insufficient_or_context_specific +KLF7 0.600589917110278 0.0191473251727434 0.311453903000669 0.113452960398979 0.693031305763568 0.886912063788091 0.240904486493758 0.4361743168386971 2.0 -0.0472531738113965 0.901995164796902 -0.0635483396447103 0.822806589473739 -0.110801513456107 0.710756890757946 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC111006.1 -1.15474193041726 0.0194101453609669 0.312583300557302 -0.784417212551775 0.126565908964697 0.508384607335028 False False False False False False False 0 insufficient_or_context_specific +RHD 1.56812622766998 0.0194286039985007 0.312583300557302 0.736501184265025 0.266982014207787 0.630039362093388 0.0199975436147734 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF155 0.551683746534435 0.0196481118237192 0.313776799941556 0.318242711770052 0.177965794853506 0.560533900274534 0.536908595244728 1.0 True False False False False False False 0 insufficient_or_context_specific +RORA-AS1 1.23204094135862 0.0197613115678099 0.313776799941556 0.844634630797096 0.108977249558966 0.485176912870447 0.0590708838183481 1.0 True False False False False False False 0 insufficient_or_context_specific +CABLES1 -0.895826130663069 0.0199500686939813 0.314086373937866 -0.505299455489545 0.202193248000238 0.57668584531318 0.5358365121038939 1.0 -0.134248428525076 0.688522162517445 -0.0183484266380166 0.95087963376246 -0.152596855163093 0.594461671378564 partial_or_other False False False False False False False 0 insufficient_or_context_specific +P4HB -0.551292458183659 0.0200014599023318 0.314117964424248 -0.29343985550981 0.243263977886606 0.609898739043611 0.394568916535076 0.427042832284281 2.0 -0.167294571591977 0.685214634579747 -0.118151282273692 0.731329321294446 -0.285445853865669 0.400318700010228 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPAA1 -0.844838990173306 0.0200596536479425 0.314117964424248 -0.651800743500614 0.0837741268996883 0.464779732481256 0.0763307105885497 0.847712859825193 -0.0719808949744065 0.805627545063573 0.0043498156141431 0.990498624561998 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPCDC 0.46384122238173 0.020179090892726 0.314117964424248 0.287920873170131 0.146264021973533 0.532796338690088 0.638025765104577 1.0 -0.0405864980747997 0.933454155949399 -0.476962038007373 0.146641609710347 -0.517548536082173 0.140428906741823 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL683813.1 0.532588333108076 0.0202013731619686 0.314117964424248 0.273279385724684 0.235967396269544 0.604926482992162 True False False False False False False 0 insufficient_or_context_specific +RPS6KA4 -0.730093286338072 0.020335868275373 0.31548815108364 -0.48051327362008 0.145709115276854 0.532658823056677 False False False False False False False 0 insufficient_or_context_specific +SLC45A4 1.28841674675761 0.0203791361090209 0.31548815108364 0.759956303034296 0.153307619137174 0.536502535641712 0.0420137913791291 1.0 -0.0348655689125035 0.933277309558909 -0.635593106645039 0.0345705918870089 -0.670458675557542 0.0398810979916504 partial_or_other True False False False False False False 0 cross_species_direction_conflict +VWDE -1.96401329371884 0.0204648055925967 0.315573355881533 -1.24598157771113 0.150489104945144 0.533583468169136 False False False False False False False 0 insufficient_or_context_specific +ZNF207 0.36801956231387 0.0205293565873755 0.315867329165892 0.186700530911536 0.274191661527448 0.637623822254105 0.0695413243038615 0.0802144080912985 2.0 True False False False False False False 0 insufficient_or_context_specific +IRF1 -0.654128068846278 0.0205831334027405 0.315867329165892 -0.551701540896149 0.055769577039051 0.42208974507405 0.459113922011221 1.0 -0.319443420477469 0.336684213763898 0.0331382437178097 0.921372441478406 -0.28630517675966 0.341468253171891 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC083798.2 0.741203685503018 0.0209641632216471 0.31919574035472 0.515894120270235 0.113472721408473 0.4924007041452 0.0187245170083773 1.0 True False False False False False False 0 insufficient_or_context_specific +NACC2 -0.566357489123302 0.0213107792901812 0.321427439636762 -0.297053461372126 0.25508201980645 0.619971446850024 0.28824259789631 1.0 -0.24878067774046 0.393803181329419 0.0273433909000141 0.923931127044008 -0.221437286840446 0.398122355104413 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABLIM2 -0.664735447957391 0.021768402479834 0.325078915674805 -0.405083292768297 0.189018665726862 0.5696999922193 0.692507112873455 0.6416039523125451 2.0 -0.178761720452003 0.668779293427642 -0.383826937170023 0.241277879287718 -0.562588657622026 0.110182982656765 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL590617.2 0.696153200044099 0.0218383742090676 0.325508705713526 0.376136932140547 0.21905694280081 0.591661090327693 0.0448471151795429 1.0 True False False False False False False 0 insufficient_or_context_specific +ITIH1 -1.11390191290417 0.0219290867106295 0.325508705713526 -0.82971101611373 0.0940602788558338 0.474102577239623 -1.63138315828503 0.0024376259986037 1.39866670978324 0.0051091206920605 -0.232716448501783 0.574210868033683 reversed False False False False False False False 0 insufficient_or_context_specific +VPS41 0.486707773245319 0.0220174201995997 0.325508705713526 0.388477172215397 0.0736681990866809 0.45226529445681 -0.0196330067441766 0.956314755614745 -0.359675003265434 0.139075090195113 -0.379308010009611 0.144071026996893 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SMARCB1 -0.554304336781106 0.0221331368198731 0.325508705713526 -0.38825535136988 0.12406131102452 0.506117936752985 0.39575992588692 1.0 0.160908660274323 0.683628821522331 -0.012539859693203 0.971447894886009 0.14836880058112 0.667585339016593 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DIRC2 0.800249232912583 0.0221550192062416 0.325508705713526 0.381758314027832 0.286486789104133 0.64687121300967 True False False False False False False 0 insufficient_or_context_specific +BAP1 -0.927061219237779 0.0222531196498085 0.325508705713526 -0.588110807681741 0.157285672229881 0.540743121915691 0.6970430741806171 1.0 0.162669763843418 0.612872257609593 0.0829766370289775 0.753618139547397 0.245646400872396 0.363758498193259 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STXBP1 0.359958460862112 0.0222892169658025 0.325508705713526 0.286359912328645 0.073931131385593 0.452862231765951 0.601162702034718 0.108037324175466 2.0 -0.0896114440252329 0.813377867232966 -0.319719797594028 0.239615881413648 -0.409331241619261 0.161030265617474 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SGCZ -1.55682430929115 0.0223606216936669 0.325508705713526 -0.434796772614768 0.515355113497847 0.799341749421224 False False False False False False False 0 insufficient_or_context_specific +MXI1 0.856221845257327 0.0224134084322473 0.325508705713526 0.653394341568327 0.0820034174533124 0.462248842216803 0.0982813562012693 1.0 -0.710429311813519 0.0306972836068744 0.588271072045211 0.0437710814469658 -0.122158239768308 0.692055477154099 reversed True False False False False False False 0 cross_species_direction_conflict +MARCH8 0.501364894748279 0.0224524441048669 0.325508705713526 0.374130132159727 0.0905033418968527 0.472234212482528 0.267189143492375 0.0573605291568882 2.0 -0.580596035956183 0.116205206742344 0.806302879527191 0.0227706624871116 0.225706843571008 0.508173835372346 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NRBF2 0.603668410820208 0.022497655324735 0.325508705713526 0.391693726108615 0.153390091247617 0.536502535641712 0.849005470079567 0.0340203013544008 2.0 -0.396944449463841 0.183392119669531 0.385501850509301 0.135348598130431 -0.0114425989545398 0.972471820635877 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC30A1 -0.758516776642106 0.0225363160934805 0.325508705713526 -0.581279225406942 0.0869637595944134 0.468259042610703 -0.374329267157896 0.237880289162034 0.451319554834372 0.104338042308593 0.0769902876764757 0.81192776574905 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CFAP44 -0.454379655030693 0.0226795440875412 0.325660651931415 -0.284464772766996 0.166757347818316 0.546947523537056 False False False False False False False 0 insufficient_or_context_specific +AL359915.2 0.52054807686869 0.022701860183891 0.325660651931415 0.384374513852731 0.097095134449434 0.478125555523304 0.108828934964605 0.146872110048914 2.0 True False False False False False False 0 insufficient_or_context_specific +DDX23 -0.517760141874309 0.02284416685063 0.326250774279766 -0.422540935059116 0.0660685778336484 0.436071024157137 -0.221355840693906 0.366160303334199 -0.315478983631584 0.139349776540004 -0.536834824325489 0.0288044608570069 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF428 0.917803763848586 0.0228622502341664 0.326250774279766 0.686503834858548 0.0804025702634764 0.460352677246087 0.550279603880683 1.0 True False False False False False False 0 insufficient_or_context_specific +AC069272.1 1.50852132212609 0.0229298839074351 0.326250774279766 0.900099721144008 0.161608883482705 0.543541307772207 0.0404085106382229 1.0 True False False False False False False 0 insufficient_or_context_specific +GNB5 0.520543519533564 0.022995413921935 0.326250774279766 0.285887269156406 0.190372603992175 0.569920796826702 -0.0572421476012575 0.919666846541066 0.0505297605213315 0.90608511988179 -0.0067123870799259 0.989031708199911 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KAZN -0.969411246243515 0.0230363838965993 0.326250774279766 -0.701171463625315 0.115849467652938 0.494328725999491 0.329565012804213 0.351194101075573 2.0 -0.426617715363469 0.25733954313929 -0.892363621033728 0.0197863226739372 -1.3189813363972 0.0055519882210824 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMPRSS6 -1.30535601753498 0.0231028716561173 0.326250774279766 -1.13433787755558 0.0535556381019176 0.417274996791505 -1.12548675628376 0.0340998812819154 0.753691323708818 0.102592290508638 -0.37179543257494 0.429709601109914 reversed False False False False False False False 0 insufficient_or_context_specific +CRBN 0.460413767416302 0.0231099253832112 0.326250774279766 0.388552741380355 0.0609320252704536 0.429268745755419 -0.48277558052373 0.195969442554011 0.650891749472914 0.0519381891771047 0.168116168949184 0.636823625502751 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PDCD4 0.505678765093977 0.0232138263896772 0.326353633851148 0.43666918689272 0.0543829883064176 0.419106270466538 -0.487241614456381 0.138520907722727 0.289587943748987 0.314255751267831 -0.197653670707394 0.525422414583605 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLAC9 -0.817304438527593 0.0232880826457027 0.326962202890065 -0.381942047125319 0.295750816149833 0.653127785976999 2.10476311564424 1.0 False False False False False False False 0 insufficient_or_context_specific +KMT2D -0.471153461886373 0.0233691277511966 0.327664343688092 -0.40108097202912 0.0587829570663517 0.427941109491281 0.199624571843216 0.419065670801039 -0.396196594344006 0.0689051940669957 -0.196572022500789 0.373813820722143 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRNIP 0.487811755542068 0.0238034054797216 0.327734533946059 0.394041859995077 0.0680461794286756 0.43786261079484 0.0371085323739577 1.0 -0.431320850328003 0.410871293751218 0.549936213793267 0.172048544195984 0.118615363465264 0.811731950736763 partial_or_other True False False False False False False 0 cross_species_direction_conflict +OSMR-AS1 0.555969484512293 0.0240081846848288 0.327734533946059 0.359375458338432 0.153460287269237 0.536502535641712 0.7721173755636379 1.0 True False False False False False False 0 insufficient_or_context_specific +B4GALT6 -0.988930396942927 0.0241374997497914 0.327734533946059 -0.469132112448393 0.301858905801805 0.65922243713362 0.0025129427610241 0.997288763468832 -0.78736149333134 0.179257411770732 -0.784848550570316 0.241612832839887 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DLD 0.578047659225298 0.0241569827314927 0.327734533946059 0.480744644971548 0.0642622512853046 0.433713214100209 -0.12447284398156 0.674598127493501 0.490771575510538 0.04349774378675 0.366298731528978 0.131975396342171 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMLHE-AS1 0.628312072286079 0.0244380759631207 0.32844355033163 0.522104353514324 0.0647440495312287 0.434440024660897 0.0347023731082089 1.0 True False False False False False False 0 insufficient_or_context_specific +DCDC2C -1.04550469512701 0.0244433008941083 0.32844355033163 -0.892196894866818 0.0591625078661156 0.428420958882338 False False False False False False False 0 insufficient_or_context_specific +LRRC20 -0.970360321122102 0.0246353905817738 0.328824846728657 -0.743198673393318 0.09968256589827 0.478125555523304 0.345626381224335 1.0 -0.457870413011959 0.459992657549225 -0.981674268559134 0.0828705795152564 -1.43954468157109 0.0287890589339682 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SHLD2 -0.358185251288057 0.024802002954799 0.330087379345907 -0.232713088471492 0.161450739944208 0.543541307772207 -0.597136200507994 0.274973819582601 0.760818840286211 0.108559073268397 0.163682639778217 0.762158108262382 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC009093.2 -0.336540284384885 0.0249306575808944 0.330087379345907 -0.180165303843879 0.263768788576941 0.626379950271573 False False False False False False False 0 insufficient_or_context_specific +COPS8 0.639079377943306 0.0250030664602583 0.330087379345907 0.388390605677674 0.176195416937184 0.558204137142182 0.557482781088126 0.6989141551781589 2.0 -0.327689607372905 0.173478267448051 0.351182266236058 0.0959160852252431 0.0234926588631527 0.927489221408977 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPL7A 0.924585916340657 0.0252494264048023 0.330087379345907 0.804441263272764 0.0542850160139468 0.419106270466538 True False False False False False False 0 insufficient_or_context_specific +SNUPN -0.567747701804229 0.025266633541977 0.330087379345907 -0.391294872311522 0.132495448408795 0.518682589655195 0.466111646875926 1.0 0.0096442678821266 0.991984778461073 0.071144946075396 0.907794803807253 0.0807892139575226 0.911503240681756 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC105942.1 0.864673214689871 0.0253462794626244 0.330087379345907 0.451591385360532 0.253446151998789 0.618991529980024 0.0228390900595365 1.0 True False False False False False False 0 insufficient_or_context_specific +SMIM3 0.828987025279944 0.0253803380710858 0.330087379345907 0.606096114666032 0.101255031438877 0.478335084675213 0.5214070698151689 0.458937539132671 0.0607514309346299 3.0 True False False False False False False 0 insufficient_or_context_specific +LDLRAP1 -0.565143394508861 0.0254967742167075 0.330087379345907 -0.359328380334357 0.172074286089167 0.553047279308805 0.635717879721824 0.3477326642858 2.0 -0.046060197917315 0.90535355614614 0.213847108696326 0.414875100682846 0.167786910779011 0.557950118364697 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INO80 -0.363668201328094 0.0255017593545837 0.330087379345907 -0.0963122166157761 0.564781849232819 0.823754286312897 0.344560188408674 1.0 -0.10650557337251 0.714168325030578 -0.256791188883155 0.247262947735665 -0.363296762255666 0.13169745483195 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MED15 -0.362554306344773 0.0255320468211144 0.330087379345907 -0.268181492480269 0.108556971076573 0.485105595812652 0.505454187802378 1.0 -0.10310676069337 0.697097681019877 -0.210202043017804 0.30479132068358 -0.313308803711174 0.153749035214437 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C16ORF74 -1.01411255649256 0.0257676071696761 0.330087379345907 -0.7799478475253 0.0999979201213082 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +UMAD1 0.403661306057511 0.0258034337030698 0.330087379345907 0.238827910029401 0.20367780649396 0.577025563405608 -0.241644526065372 0.478468120409623 -0.304907398920619 0.277449529701259 -0.546551924985991 0.0804216787755617 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MID1 0.679650350357296 0.0258748723646874 0.330087379345907 0.553316749789296 0.0776380529651771 0.456913357417135 0.244052386800937 0.12972263720377 2.0 True False False False False False False 0 insufficient_or_context_specific +RPL34 0.537100551996027 0.0258879576030033 0.330087379345907 0.443729752538522 0.0726654310120276 0.449108979935905 0.389908329160323 1.0 True False False False False False False 0 insufficient_or_context_specific +AP002518.2 1.45670599833207 0.0259855435450054 0.330444628372997 0.925847931950427 0.154601656952136 0.538529955163527 0.148045993975001 0.135559626148255 2.0 True False False False False False False 0 insufficient_or_context_specific +ZYG11B -0.329413920662121 0.0260585672490922 0.330680712759514 -0.251715159627979 0.0939891268162471 0.474102577239623 0.0938270465941468 0.813377867232966 0.0741268268001186 0.805551564721287 0.167953873394265 0.593708026904035 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRPRA -0.706372709149262 0.026262527224306 0.330935942403272 -0.457127751796248 0.184770755845085 0.566601696256872 False False False False False False False 0 insufficient_or_context_specific +ZRANB2 0.303479758115614 0.0263865285283555 0.330935942403272 0.251072972767369 0.0688043170192527 0.438727346175897 0.0999203216577628 1.0 -0.237801848982062 0.335139138234414 -0.168559893126631 0.427585189768408 -0.406361742108693 0.080586674882408 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RAB27A -0.397457793972486 0.0263921257343773 0.330935942403272 -0.295568830619601 0.0878958699173754 0.468622105620855 -0.130476740641858 0.907849810643776 -0.320963449897447 0.667343290293859 -0.451440190539305 0.603300056050431 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC37A3 0.567404337819451 0.026493790739733 0.331425407194067 0.173350175658968 0.491266382846737 0.785509848901139 0.297579110558855 1.0 True False False False False False False 0 insufficient_or_context_specific +AL357153.2 0.721705883411055 0.0266023588527786 0.331425407194067 0.502471888337283 0.122232031046052 0.5038394341269 0.0705092223471386 1.0 True False False False False False False 0 insufficient_or_context_specific +TAF4 -0.500583998634135 0.0266471920280312 0.331425407194067 -0.409203386885561 0.0744114507912503 0.452862231765951 -0.205519126410459 0.439864453842224 -0.47385824746288 0.0474133721758967 -0.679377373873339 0.0156928242763213 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM10 -0.521720467647147 0.026658413808584 0.331425407194067 -0.417214198208699 0.0891387595785492 0.470236852611986 -0.145117561224919 0.629416114107111 -0.295865709893742 0.211391738693045 -0.440983271118662 0.0918584513043619 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FRAS1 -1.15459240618821 0.0273855775805339 0.333641420347605 -0.996565623549538 0.0560734768554644 0.423176389306643 False False False False False False False 0 insufficient_or_context_specific +ADH1B -0.665933566144256 0.0273979078841991 0.333641420347605 -0.562745288901599 0.067132423072603 0.436950863873319 0.74445453300334 1.0 False False False False False False False 0 insufficient_or_context_specific +S100A13 0.673001868150544 0.0274907135341981 0.333988882696468 0.487408110350631 0.107087694857735 0.483261130274234 0.546866769997831 0.315757623321373 0.0382683210075381 3.0 -0.715930040523858 0.0617548854468982 0.784787357783416 0.0288516555533807 0.0688573172595583 0.859888104613356 reversed True False False False False False False 0 cross_species_direction_conflict +AC093525.4 0.83819399231382 0.0275756784559876 0.334264079378091 0.72910835592657 0.0590392853506767 0.428240742414856 0.0349207538441029 1.0 True False False False False False False 0 insufficient_or_context_specific +PAPLN 0.993198025785114 0.027768064370543 0.335440759295416 0.711325479970845 0.121708662892707 0.503485437181972 0.9799136545688241 0.237875374431762 0.149213414517267 3.0 -1.71999172379873 0.0043053178576497 2.02641043155283 0.0018504020590579 0.306418707754102 0.495131319458432 reversed True False False False False False False 0 cross_species_direction_conflict +GSDMD -0.590802116708998 0.0280613641388198 0.337217014198832 -0.351352000434235 0.189595909202251 0.569886897607216 0.800151791407015 1.0 -0.499720589235815 0.10220307992849 -0.533409397202548 0.0610256644262438 -1.03312998643836 0.005656323828614 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TNFRSF1B -0.678259564375684 0.0281279713576125 0.337471729083719 -0.510832185752222 0.115566015096972 0.493786316225751 0.5322267417576579 1.0 -0.119871476378357 0.731556142006226 0.11390807839791 0.687061129559832 -0.0059633979804476 0.98630920744418 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COASY -0.839074422200586 0.0283745456587241 0.338757833934729 -0.648890362219007 0.100245721368708 0.478125555523304 -0.673208216583695 0.0521755905277978 0.774751367018786 0.0195095243655345 0.101543150435091 0.765218068922241 reversed False False False False False False False 0 insufficient_or_context_specific +AP001528.2 1.05421599885195 0.0285694610163606 0.339914872505016 0.603059185981277 0.190760183170392 0.570066802692612 0.0414222459233645 1.0 True False False False False False False 0 insufficient_or_context_specific +RAB2B 0.48944928480001 0.028629739764601 0.340014389690278 0.140404509226523 0.546289707592605 0.81552807024429 True False False False False False False 0 insufficient_or_context_specific +TBC1D15 0.502493916976882 0.0288036988843563 0.341067652056998 0.299133806635094 0.200187096938635 0.575556382365159 0.08349290124662201 0.0597366911242801 2.0 -0.285162389350098 0.401942090284408 -0.0865060094914938 0.780894242740577 -0.371668398841591 0.222018100166938 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RMND5B -0.391596926814977 0.0289285964121735 0.341108533371332 -0.350535881330585 0.0549158836189396 0.420068725637921 -0.0447150452486809 0.922409786806701 -0.0262390145102864 0.940311244788927 -0.0709540597589673 0.848856992637175 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NRP2 0.698727664477869 0.0290280452967647 0.341670125131819 0.120067783609478 0.681108244100441 0.881267259952508 0.630150973308824 0.8627678207171608 0.139689774642337 3.0 -0.214136167562727 0.560983902319736 -0.0384985466302771 0.910368168826668 -0.252634714193004 0.424991321226984 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC078881.1 -0.546119444941826 0.0291566055773843 0.342001418870157 -0.46707049368737 0.0669761041527277 0.436862290339161 False False False False False False False 0 insufficient_or_context_specific +PCNP 0.413347985373111 0.0293111332655707 0.342330691391477 0.248571905089636 0.203127441790728 0.576835372560841 0.042172513501111 1.0 -0.223702122088848 0.47536338372137 -0.0257731162379366 0.931942990277106 -0.249475238326784 0.364011360670613 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AHSG -0.896782377391975 0.0296555714684025 0.342436744765113 -0.616568546940071 0.139233191173797 0.524072738828147 -0.532406942614087 0.337730132501224 0.843579185259942 0.0905570145123985 0.311172242645855 0.550009646260454 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ORC3 0.422417941139543 0.0296769863099146 0.342436744765113 0.118452484222913 0.566099112308784 0.824113119711934 -0.0825344975542339 0.84699343016531 -0.213021890103459 0.474280205993542 -0.295556387657693 0.356079848379937 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL136366.1 -0.870871965285991 0.0299054025988994 0.343028363112338 -0.693366634162499 0.091715726899136 0.472460751419842 False False False False False False False 0 insufficient_or_context_specific +UQCRH -0.56281674620615 0.0301354265779909 0.344712712687355 -0.489351635332618 0.0641913737627306 0.433610060260339 -0.179156958040924 0.901995164796902 0.51956636917681 0.548380845582369 0.340409411135886 0.753784269682915 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AGPAT2 -0.473347848370629 0.0301980916489465 0.344732933930333 -0.255123136675512 0.286604304721441 0.646942193395173 -0.468817481816419 0.219905644481465 0.848282953495883 0.0233695746073517 0.379465471679464 0.278098076185403 partial_or_other False False False False False False False 0 insufficient_or_context_specific +JHY 0.669884818564403 0.0302222410404268 0.344732933930333 0.34705468500217 0.279883592065015 0.642114507827558 True False False False False False False 0 insufficient_or_context_specific +ENTPD4 -0.370030696091519 0.0302852328132767 0.344899078569424 -0.288039992086455 0.0931719033989356 0.472709733823144 0.4624301093013921 1.0 False False False False False False False 0 insufficient_or_context_specific +ZBTB20-AS5 1.01895719622836 0.0304055758757012 0.345387673449279 0.867894837470833 0.0634035946671602 0.432999502601999 0.7784472866659449 0.0389136118108764 2.0 True False False False False False False 0 insufficient_or_context_specific +NELFB -0.415300608088829 0.03048885315919 0.345387673449279 -0.327556581679188 0.0989826346662328 0.478125555523304 -0.0080145223912841 0.981117342485003 -0.458759960854474 0.0590622678464846 -0.466774483245758 0.0703872505661404 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCTN3 0.612531168958536 0.0306712724427552 0.346514297436479 0.282977111403343 0.336130078659188 0.684718759551425 -0.0020376283020249 0.996779540451992 -0.448742172745303 0.182807229960284 -0.450779801047328 0.224912246829819 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRPV2 -0.607480117421726 0.0307049268709873 0.346514297436479 -0.532183057239655 0.0637988168424644 0.432999502601999 0.823175409232604 1.0 0.882894590332396 0.0839378659070161 -0.986361111913558 0.0288330391722868 -0.103466521581162 0.859101658571639 reversed False False False False False False False 0 insufficient_or_context_specific +PHF20 -0.507927422534948 0.0307195853760697 0.346514297436479 -0.387713560553634 0.110659261159882 0.488028604563923 -0.0152572394191311 0.965819679450514 -0.42285632203899 0.0889977295051248 -0.438113561458121 0.0987014398836702 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDC42BPB -0.381134994910752 0.030885851426013 0.347302523784953 -0.33186389287648 0.0675653598468269 0.43786261079484 0.226204086017378 1.0 -0.192034741971551 0.468845290715915 -0.353752584623692 0.116788341039413 -0.545787326595243 0.0325592579743564 partial_or_other False False False False False False False 0 insufficient_or_context_specific +YWHAE -0.336065385473136 0.030958975939765 0.347728582948978 -0.29692675453714 0.0604630078217213 0.429268745755419 0.590986535251294 1.0 -0.0441849552723557 0.915500361643522 0.246193688928255 0.376416306268218 0.202008733655899 0.500450078801184 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL18 -0.493290648533713 0.031274065802506 0.349912402212569 -0.37181514392369 0.119843253830443 0.500502724013779 0.0808572067270207 0.865897191065506 -0.319780903610739 0.320622606726728 -0.238923696883719 0.517547452823532 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL2 -0.420938520113777 0.031747118617151 0.351849953588893 -0.377905584521639 0.0589464592221333 0.428240742414856 -0.466702628268419 0.334732239712681 0.68589106784953 0.0935082941601426 0.219188439581111 0.625804260474455 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC17A9 -1.36333888405307 0.0317542920401423 0.351849953588893 -1.14507124524283 0.076537660210478 0.455668688469891 0.525473555279809 1.0 -0.0499593040616059 0.921831517302813 -1.23112078862401 0.0059324002168397 -1.28108009268562 0.0085974855976623 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRSF2 -0.499054547046767 0.0318257914072166 0.351849953588893 -0.42995615920589 0.0644982915466862 0.434017184289301 0.3985824362953971 1.0 -0.0339181714015172 0.914375488676743 -0.0872891291861538 0.69600837463254 -0.121207300587671 0.602338874331942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC35E3 0.544138953588289 0.0319955940440506 0.352489948368348 0.263275572738782 0.308471072614617 0.662330926800867 0.0495512117270082 1.0 -0.431717881385861 0.110824479928825 -0.087289639182714 0.725525822333594 -0.519007520568575 0.0501970085989231 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KCNK17 -1.36611125572777 0.0322022915943453 0.352695607872978 -1.23651059284682 0.0562049583987928 0.423380157386529 False False False False False False False 0 insufficient_or_context_specific +AP000787.1 0.798884590829909 0.0322239002226928 0.352695607872978 0.627081957612858 0.0865987318698251 0.467677448123587 0.0271536368093105 1.0 True False False False False False False 0 insufficient_or_context_specific +GNAI2 -0.452824175062938 0.0322363384729517 0.352695607872978 -0.383041135204002 0.0784012112385322 0.457322349441485 0.0498419278269475 0.343250273949935 2.0 0.114942405500037 0.751194800228106 -0.583216200639545 0.046409360022858 -0.468273795139508 0.110013093328389 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ULK2 0.481040484571096 0.0324063634362668 0.353822528604038 0.393098291171511 0.083884327812394 0.464779732481256 0.0749351519496669 1.0 -0.170661439939086 0.580042823317237 0.400734937131559 0.106630624482327 0.230073497192473 0.376034916014796 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RNF14 0.634593558234245 0.0324690045567937 0.353852676891235 0.385165221746137 0.198474457710103 0.573943476119181 0.0414858685697194 1.0 -0.0793019343902102 0.843101546575771 -0.370370512437172 0.191190192383777 -0.449672446827382 0.136527757585198 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PPP4C -0.518215080379069 0.0327651415886934 0.355262019067548 -0.456402334659284 0.0615803096310683 0.430858123979337 0.167165601288379 0.570591253420651 0.179650820841029 0.436933438497611 0.346816422129407 0.166576239234014 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLKB1 -0.977314502690776 0.0327737456499139 0.355262019067548 -0.883151968051737 0.0563948311058688 0.423637335496119 -1.50697171836366 0.0054214743032507 1.48112080669075 0.0052482103036662 -0.0258509116729124 0.958216666061011 reversed False False False False False False False 0 insufficient_or_context_specific +PDIA4 -1.02155580480882 0.0330818341920093 0.35660210579473 -0.800624586059559 0.0999499040950658 0.478125555523304 -0.470028545835812 0.363141198119351 0.527616500605262 0.234985387067592 0.0575879547694497 0.916789352770126 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EEF1B2 0.564876335797243 0.033408542970285 0.356792055793388 0.465314818160921 0.0848809365699044 0.465302662671366 0.007675302015006291 1.0 -0.0477097244127927 0.917945009132389 0.124154295671989 0.706107411733477 0.0764445712591961 0.837464029696153 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC02388 1.12487894620535 0.0334323402790852 0.356792055793388 0.559279569774119 0.294360557300558 0.652324662738756 0.8718736144014009 0.442943632527225 2.0 True False False False False False False 0 insufficient_or_context_specific +LZIC -0.488200273923162 0.0335520265416503 0.356792055793388 -0.296522124461721 0.213480169328327 0.58619600202041 0.157937614169632 0.668122970341972 -0.370369476554472 0.188122903041479 -0.21243186238484 0.499807375946817 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZSCAN18 0.471019756038137 0.0335569720972565 0.356792055793388 0.314947253764705 0.175978749102172 0.557953042949168 True False False False False False False 0 insufficient_or_context_specific +FAM102A -0.747732908241787 0.0337237926656483 0.357997905551035 -0.585606072794955 0.0988944963856308 0.478125555523304 0.53789529832255 1.78470372100772 2.0 -0.446860587477806 0.202559296088674 0.305746866172924 0.306038125638246 -0.141113721304881 0.681285352656983 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATF7IP2 -0.537677291871639 0.0337721077788247 0.357997905551035 -0.350250218442343 0.167192414349103 0.547506873424212 False False False False False False False 0 insufficient_or_context_specific +KLHL8 0.547459737941937 0.0338904297713173 0.358891833024642 0.451596046365021 0.0813697905632429 0.461068439742811 0.0801572718671926 1.0 -0.374581467859592 0.479149150542878 -0.186131345720283 0.677585067137296 -0.560712813579875 0.232991998640449 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MTMR12 0.480250203450616 0.0341891043680349 0.361329893811525 0.257245248919669 0.253399868267651 0.618991529980024 0.9135501232789391 1.0 -0.0904696566669291 0.816891664028371 0.0385757171378044 0.904387017949864 -0.0518939395291246 0.88132640113159 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CEP126 0.550540720170588 0.0345107489355968 0.362912835918358 0.44278163188178 0.0956496576243324 0.47569521889622 0.0805999429895972 1.0 True False False False False False False 0 insufficient_or_context_specific +SPACA6 -0.527880797887637 0.0346558498033774 0.363322396620508 -0.484402953834018 0.0571587605162587 0.424455207563489 0.395330801158928 1.0 0.377011047129479 0.244345138176277 0.0483603373939008 0.880179498944025 0.425371384523379 0.155725439871279 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTRF1L 0.691868908077273 0.0348167330255449 0.363322396620508 0.376647407990594 0.241685254653532 0.608725035015447 -0.0345810360225685 0.936257534403958 -0.278414866635608 0.328212687680469 -0.312995902658176 0.312306781845668 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ANKRD37 1.68484336779438 0.034849816176495 0.363322396620508 0.747414451307443 0.330075042249752 0.678530431478365 True False False False False False False 0 insufficient_or_context_specific +NMI -0.675374928264927 0.0349859215728639 0.363322396620508 -0.516993517853071 0.126610006668498 0.508384607335028 -0.145664990615523 0.684020812566494 -0.300857764330336 0.275484825570154 -0.446522754945859 0.134670205512877 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLA2G2A 1.71756582918615 0.0350033131935875 0.363322396620508 0.459240223259022 0.547816311726663 0.816156774016399 True False False False False False False 0 insufficient_or_context_specific +SH3BP2 -0.568440506109659 0.035072641440888 0.363322396620508 -0.420152396933231 0.135902747642454 0.523136620282319 0.197443547422148 0.4417639673027861 2.0 0.113978391973384 0.812840616802995 -0.635369946950697 0.0721530524052892 -0.521391554977313 0.168879378608484 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC025159.1 0.732686163847587 0.0351640753553411 0.363322396620508 0.123834391511499 0.732815016429034 0.904431845923655 True False False False False False False 0 insufficient_or_context_specific +AC130324.2 0.765850073532546 0.0351766222051524 0.363322396620508 0.652181739536284 0.0758634269832178 0.45450267784572 0.0269858945807958 1.0 True False False False False False False 0 insufficient_or_context_specific +FOLH1 -1.1707857784624 0.0352219508464873 0.363322396620508 -1.06872430302579 0.0579826464039734 0.426512790230505 0.331001954982606 1.0 False False False False False False False 0 insufficient_or_context_specific +ZNF397 0.462447834521273 0.0352376624587108 0.363322396620508 0.349386910587718 0.112947513724867 0.49236162258759 True False False False False False False 0 insufficient_or_context_specific +BEAN1 0.723251486951938 0.035305295232641 0.363322396620508 0.529927923892217 0.113273928224608 0.4924007041452 0.02526023049510601 1.0 True False False False False False False 0 insufficient_or_context_specific +GORASP1 -0.686909148072247 0.0355238901551344 0.364080686597539 -0.614332125360355 0.0652159833214018 0.435515719106489 0.650939068981327 1.0 -0.426033046848885 0.248819760114183 0.23716416302095 0.453590443867895 -0.188868883827935 0.59049754983198 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL513327.1 1.52449891455302 0.0355939423657688 0.364148104164522 1.22726560251401 0.0875263061760465 0.468622105620855 0.04940377961462099 1.0 True False False False False False False 0 insufficient_or_context_specific +AC022126.1 0.907377495199773 0.0356826814860381 0.364702566437164 0.749691734942369 0.0901835576597099 0.471832508310811 True False False False False False False 0 insufficient_or_context_specific +NRDE2 -0.363510102165449 0.0357934209728083 0.365192244653577 -0.317506689240876 0.0706968871016188 0.443801226075734 0.00316748493135319 1.0 -0.0955868543905576 0.815171844574446 -0.361722641595937 0.211421354651901 -0.457309495986494 0.152505211614686 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC24A3 0.538063680917141 0.0357997701474192 0.365192244653577 0.414350077404235 0.109671488198585 0.485701162919741 0.356699878160225 0.195481575621985 2.0 -0.0260792746240687 0.950310011565912 -0.510667054695666 0.0785031474596826 -0.536746329319735 0.0873121709081415 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AKAP17A -0.547769952296405 0.0360695507097729 0.365949036346115 -0.474753187068807 0.0715916400706888 0.446327053773367 False False False False False False False 0 insufficient_or_context_specific +METAP2 -0.435836538852028 0.036081923360135 0.365949036346115 -0.358711412515761 0.0942235332372465 0.474102577239623 -0.0480519043398067 0.874637657952132 0.06469695292091 0.774791882855681 0.0166450485811033 0.949130547036895 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP2R1B -0.70878208423882 0.0362210764607674 0.366655920683396 -0.398058720338501 0.265684463995451 0.62822323708046 0.561109598986584 1.0 -0.294602711693099 0.366763919617623 -0.523483763339155 0.0725722252163001 -0.818086475032255 0.0192554552464092 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BEND4 -1.15820541641697 0.0363225575569652 0.366820534891745 -1.02232560180296 0.0727153634747747 0.449108979935905 -0.330826124276613 0.681365531915382 -0.418013932848507 0.50054401526696 -0.748840057125121 0.278615448938962 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CALCOCO1 0.666727171010315 0.0363947334584354 0.366820534891745 0.324818725915797 0.316865481763778 0.669290253214092 0.083210543022231 1.0 -0.270839305140682 0.370609917711354 -0.0015128887170466 0.996376000952948 -0.272352193857729 0.316336049302064 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GLMN 0.455539682189315 0.0364368463329501 0.366820534891745 0.380404829344212 0.09193693663314 0.472460751419842 0.314415102089015 1.0 -0.41126409948723 0.412448068065036 -0.302880958493082 0.472617898594952 -0.714145057980311 0.124027214028329 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CCDC136 -0.928872076938701 0.0364434132322898 0.366820534891745 -0.780018016831048 0.0847750590191472 0.465302662671366 0.223223142734309 0.837907232278894 -1.30540602881914 0.102792116647019 -1.08218288608483 0.252873437389011 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KATNAL2 0.894730753463107 0.0364457985509984 0.366820534891745 0.535407828297246 0.227197591417167 0.599238613585423 0.045787111207887 1.0 True False False False False False False 0 insufficient_or_context_specific +AC072022.1 1.04187465806425 0.036522286205228 0.367240283575997 0.756926395661915 0.116992319512222 0.496449831511094 0.0451673476474454 1.0 True False False False False False False 0 insufficient_or_context_specific +TMEM214 -0.490945803049295 0.0366554206701183 0.367878261820445 -0.392030508313768 0.108358846591448 0.485070295736365 0.7619249234514549 1.0 0.0178111610600555 0.957440974715565 -0.19054299152761 0.403459061288665 -0.172731830467555 0.479481988453045 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INPPL1 -0.617187653603035 0.0369745641644159 0.368139714899329 -0.441586532758828 0.155710034319759 0.539558215777 0.346535349806778 1.0 0.854668381818066 0.0117210420422023 -1.15809737030263 0.0025337729375146 -0.303428988484561 0.29470812644929 reversed False False False False False False False 0 insufficient_or_context_specific +ARHGEF1 -0.468469467389848 0.0369966635087918 0.368139714899329 -0.355069183939856 0.130347217746567 0.515626049070159 -0.182451620848106 0.570591253420651 -0.585446639342074 0.039110718478162 -0.767898260190181 0.0172795093274116 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FOXO1 0.881559647795864 0.0370300539703013 0.368139714899329 0.507970595317686 0.236057691790842 0.604926482992162 0.4056735632338561 0.274964958219735 2.0 -0.533032700951574 0.0782240189594798 0.494326450418702 0.0672879620550469 -0.0387062505328726 0.90460840202147 reversed True False False False False False False 0 cross_species_direction_conflict +TBC1D9B -0.330530503829221 0.0370513977411101 0.368139714899329 -0.305856157902577 0.053297150932587 0.416631456505827 -0.154337173428201 0.552892169078678 0.46735746762645 0.0394463580733521 0.313020294198249 0.159710132474105 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFIC -0.599431411792274 0.0371331704189532 0.368139714899329 -0.558175244735349 0.0558431845498036 0.422187694224726 0.7078692605002941 0.7338968195164691 0.133226372343208 3.0 -0.400884025988861 0.103657565873355 0.426656769991223 0.0605094278135818 0.0257727440023627 0.922845826959116 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IFRD1 0.556172821041878 0.0371475925386311 0.368139714899329 0.387008021826998 0.146270775639823 0.532796338690088 0.0756226989769803 1.0 -0.0695266948749208 0.826861264369012 -0.426807233143572 0.0704009511962482 -0.496333928018492 0.0512849433540915 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RASA3 -0.507132275673576 0.03714848014242 0.368139714899329 -0.319459401403814 0.215969672114711 0.587985507526332 0.675136441642533 0.423734985248185 2.0 0.536327526499707 0.0657749925946476 -0.221021694324683 0.372587810505131 0.315305832175023 0.236334419408948 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP5 -0.730643104455701 0.0371500512370355 0.368139714899329 -0.667521693350151 0.0613018540231598 0.430049817127257 0.0106936483904961 0.976319554137668 -0.353470813808799 0.150826116251216 -0.342777165418303 0.186081454558579 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNOT8 0.519952423906306 0.037169628346532 0.368139714899329 0.328464433440987 0.184856849080484 0.566634626507485 0.0517973034373286 1.0 -0.158631690030446 0.546199595250828 0.226600324693298 0.279403530922978 0.0679686346628527 0.785251167737803 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NTAN1 0.620833424032942 0.0373479747260867 0.368446063719788 0.530930450745153 0.0781193505483178 0.457322349441485 -0.0027982808327515 0.994302327353405 -0.298047369149669 0.220997882653384 -0.30084564998242 0.252690094700539 partial_or_other True False False False False False False 0 cross_species_direction_conflict +STARD8 -0.878304501271687 0.0375781132982291 0.368446063719788 -0.574921036392989 0.177698835504881 0.560377630006132 -0.0713623260827024 0.883206679897385 0.268228754801352 0.421804385210613 0.19686642871865 0.592132586553467 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC073343.2 0.578873009384436 0.0378742028175884 0.369545139957322 0.544253108041492 0.0514600503427477 0.410669094118466 0.0336263405321412 1.0 True False False False False False False 0 insufficient_or_context_specific +WDR26 0.306201524366097 0.0379635624109591 0.369545139957322 0.253832877755329 0.0843474220813225 0.464779732481256 0.543577345516092 1.0 -0.086766821046622 0.781810193990744 -0.218362425742905 0.353074152742153 -0.305129246789527 0.214191647110113 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRIM38 0.367410126305589 0.0379765558679385 0.369545139957322 0.326423639694995 0.0658594111619329 0.435846392502307 0.41811979671116 0.0460559415843864 2.0 True False False False False False False 0 insufficient_or_context_specific +PLSCR1 0.470825334575974 0.0382882472315036 0.371182087199248 0.303101888883833 0.212198778964407 0.584959453865852 -0.51908417503736 0.227737044526761 0.283104212123759 0.444243239923244 -0.235979962913601 0.562508519545956 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL158071.4 0.843086351983511 0.0385355249038452 0.371584398994206 0.515686455972398 0.181815120288302 0.564455779510072 True False False False False False False 0 insufficient_or_context_specific +RUFY1 -0.411234406224137 0.0386179471468591 0.371584398994206 -0.301980233200741 0.140759941381549 0.526401063874107 0.327301610089842 1.0 -0.442941508463357 0.149029449922273 0.0947642336477618 0.736917661904505 -0.348177274815595 0.217512244499808 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SORBS1 0.509731388971826 0.0387850557521097 0.371768175769319 0.139996313545263 0.57964735391259 0.831962583280196 0.8229172402927231 0.792120001935623 0.0468181061963759 3.0 -0.142068760203409 0.684136891346092 -0.085964006093617 0.770505482908639 -0.228032766297026 0.427280308808576 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TCAF2 0.620397862530729 0.0388424534226387 0.371802922244986 0.451978573510469 0.137922735632896 0.523810858054217 0.026641859383646 1.0 -0.162642816480099 0.855680227274421 0.477319983032423 0.385430635063345 0.314677166552325 0.636823625502751 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PBLD -0.782852137189575 0.0392340380448841 0.374084143383926 -0.683050966950635 0.0743243602889831 0.452862231765951 False False False False False False False 0 insufficient_or_context_specific +ZNF30 -0.712587339249723 0.0393973472620941 0.374736209363233 -0.572817610833804 0.100334290802978 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +LARGE1 -0.365021354598265 0.0394422497952097 0.374825628566898 -0.275632445079454 0.120449296446093 0.501524675000431 0.455307875837215 1.0 0.576461667725807 0.0728743120298899 -0.739463943661911 0.0171388557501631 -0.163002275936105 0.608119365637099 reversed False False False False False False False 0 insufficient_or_context_specific +HACL1 0.409887318096669 0.0394794722607858 0.374841967742245 0.246662036362242 0.214150683809264 0.587120986667932 0.0729333985946635 1.0 -0.642045254009778 0.325638300723061 1.17739322572313 0.0489796245256278 0.535347971713347 0.359562730812659 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CARF 0.390564040156595 0.0395945381369787 0.374868680542814 0.130066711947189 0.504951872414552 0.792832263802515 0.6917244871017391 1.0 True False False False False False False 0 insufficient_or_context_specific +ABCA6 0.770554730675479 0.0398262067868265 0.376104732786506 0.369219771722748 0.337192591581058 0.685057785656405 0.9405837026913391 0.222155744102198 0.366841979575649 3.0 -1.04690943121449 0.0130006589611637 1.15823773178681 0.0062631761700032 0.111328300572323 0.773722888053667 reversed True False False False False False False 0 cross_species_direction_conflict +CD302 0.68233875229785 0.0398951306943937 0.376418936435575 0.314415585834896 0.346524787399673 0.691739214476413 0.0369097839350522 1.0 -0.452024845689301 0.117172726940726 0.568383563926576 0.0380166643766925 0.116358718237275 0.682847153251179 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLIN4 -1.26200226295535 0.0399843844672913 0.376490056204699 -1.17035471961952 0.0592902558317317 0.428473540531152 -0.149604148157627 0.78150381255069 0.375336230023544 0.322278415348674 0.225732081865917 0.60228938172617 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM273 -1.33609489729097 0.0400096460562297 0.376490056204699 -1.26487647833873 0.052947383696462 0.416277817549129 0.715323354706074 0.0603510245775933 -0.873916785864685 0.0157511004459988 -0.158593431158612 0.682937653801204 reversed False False False False False False False 0 insufficient_or_context_specific +HKDC1 1.91530581347989 0.0400716926395419 0.376738139704616 1.793461307864 0.0518374947438196 0.411906134371584 True False False False False False False 0 insufficient_or_context_specific +SHLD1 -0.545440342894609 0.0403873732711005 0.377731883491073 -0.408526344799412 0.139438144658884 0.524470228467581 -0.718196058760928 0.0939914368072628 0.6325952646978 0.0828705795152564 -0.0856007940631279 0.841465089377446 reversed False False False False False False False 0 insufficient_or_context_specific +CAMTA2 -0.432083723790435 0.0404702534806174 0.377731883491073 -0.385217677487161 0.0726967041387624 0.449108979935905 0.0351312555588078 0.918634477287914 -0.311079238193692 0.181346342106623 -0.275947982634884 0.262949493231076 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADAMTS9-AS2 0.812025369485527 0.0405604662184782 0.377731883491073 0.583898231514847 0.141942309432211 0.527314181205237 0.208863541408579 0.153691249655626 0.302755213471829 3.0 True False False False False False False 0 insufficient_or_context_specific +PTPRQ 1.05494093082155 0.0405674188062816 0.377731883491073 -0.241675884048634 0.621313884392004 0.854367282027973 0.760998613933864 1.0 False False False False False False False 0 insufficient_or_context_specific +AC008050.1 0.666066524027743 0.0405856585835416 0.377731883491073 0.30665997330282 0.349132658697741 0.694288655897113 True False False False False False False 0 insufficient_or_context_specific +PTPN9 -0.326660678973823 0.0406296855467447 0.377731883491073 -0.247663582640285 0.133097381059497 0.519212049578983 0.280300493593941 1.0 0.0865812066931742 0.77654122523999 0.156263774211406 0.488421524436378 0.24284498090458 0.308657601760708 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE2O -0.370521309120298 0.0406424909685413 0.377731883491073 -0.255609102789403 0.167789107363022 0.547623080618609 0.255108077434785 0.468839098744151 -0.264526341673607 0.343074663072673 -0.0094182642388218 0.980873751510795 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC47 -0.661520395638527 0.0407426054757126 0.37799686169822 -0.575438930376274 0.085902291004067 0.467503293000484 -0.192368462521659 0.439961253243198 0.107805502616196 0.614908368107979 -0.084562959905463 0.722999050469451 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB21 0.559804234214911 0.0413458007183485 0.382249530634259 0.39406393066514 0.166004292469971 0.545664171823771 -0.100330833368937 0.704756194917616 -0.0026527303381826 0.991552677629496 -0.10298356370712 0.655135512854487 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PPARA -0.616164914567175 0.0415947079092811 0.383543166904969 -0.558630427111258 0.0679729110747863 0.43786261079484 1.00101684425076 1.0 -1.02543509165599 0.0306951934317138 1.34546538310927 0.0064918884583111 0.32003029145328 0.436822972756224 reversed False False False False False False False 0 insufficient_or_context_specific +BCL11B 1.52612965057018 0.0417375050123745 0.383572450100128 0.870163160240763 0.225045589335604 0.597066838417367 0.537151721163448 1.0 True False False False False False False 0 insufficient_or_context_specific +RAB40A 0.733172484988524 0.0418738528074237 0.383572450100128 0.234109458134199 0.50298105274672 0.79229878349175 True False False False False False False 0 insufficient_or_context_specific +PPIP5K1 0.654007551386619 0.0418822441298984 0.383572450100128 0.40635437657673 0.216503799648338 0.588226226630764 0.039575226599065 1.0 -0.651448927360821 0.16757691276886 -0.853960033308602 0.058476669634099 -1.50540896066942 0.0080694540300314 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MTCP1 1.8188637897943 0.0418984625601633 0.383572450100128 -0.316183644882628 0.696309163583358 0.888447116319334 -0.173460415724993 0.773537708168703 -0.891472005158541 0.0639146207073074 -1.06493242088353 0.0451184617036066 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLP2R -1.2586665279249 0.0419181835435293 0.383572450100128 -1.214424953347 0.0505484351149636 0.407397235071593 0.789209370009106 1.0 False False False False False False False 0 insufficient_or_context_specific +POLD2 -0.675349259819466 0.0419185965600651 0.383572450100128 -0.578544629206893 0.0880111955332505 0.468622105620855 0.270658751062526 0.609071693102667 2.0 -0.149118406255543 0.726514481255491 0.127354041919326 0.698243579301301 -0.0217643643362165 0.956411870324984 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PELI2 0.737095689655026 0.0419248538942553 0.383572450100128 -0.0743618956440634 0.856728592283025 0.956672710452055 0.395646321897906 1.0 -0.336260578152992 0.320349903765884 0.0127797596972184 0.970152811194507 -0.323480818455774 0.292318017000595 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHACTR3 -0.90083263135824 0.042181105815712 0.383730849135154 -0.648244990051691 0.157566203881216 0.54100292051313 0.7064724809633941 1.0 False False False False False False False 0 insufficient_or_context_specific +AL512625.3 1.1324129984607 0.0422276101853385 0.383730849135154 0.730506526660578 0.172642192196207 0.553858965567902 0.0252396066814392 1.0 True False False False False False False 0 insufficient_or_context_specific +LETM1 -0.656175509134663 0.0422913016646047 0.383730849135154 -0.542914901581527 0.100281310752607 0.478125555523304 -0.134678877284883 0.675500646426359 -0.462109155574788 0.0765528040091499 -0.596788032859671 0.037480318894471 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HPR -1.09313570765689 0.0423105693963952 0.383730849135154 -0.642271153766777 0.264021521206395 0.626554106742441 False False False False False False False 0 insufficient_or_context_specific +AGPAT4 -0.477033205878978 0.0423607793075444 0.383730849135154 -0.434454380997145 0.063516807538908 0.432999502601999 0.542550984288897 0.200513544106587 -0.281536782659258 0.422636363508653 0.261014201629639 0.521855979873346 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC021504.1 1.32372680016729 0.0423992752742005 0.383730849135154 1.2241779198801 0.0594192207789587 0.428473540531152 0.0564931017783205 1.0 True False False False False False False 0 insufficient_or_context_specific +NFATC2IP -0.438465297643202 0.0424826977894556 0.383730849135154 -0.315258571145218 0.159452334751048 0.543271287169906 0.344965990788265 0.488335954733525 -0.617347889125477 0.117032950560062 -0.272381898337212 0.566202946676252 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IFI16 0.597646125763332 0.042525784695419 0.383749773345499 0.569719822606067 0.0549281534933228 0.420068725637921 0.71087224584938 0.134177169010708 2.0 True False False False False False False 0 insufficient_or_context_specific +YPEL3 0.7603923199764 0.0427031921156587 0.383949763302995 0.587365534441271 0.107330727514533 0.483446169410598 0.0585440019923416 1.0 -0.0347580564847376 0.915993062050496 -0.110011346767893 0.633690597456881 -0.14476940325263 0.54959516694183 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ATP8B4 0.679389040285142 0.0427814686443215 0.383949763302995 0.4895054259779 0.159928049300266 0.543541307772207 0.831701916826181 0.437119846671971 2.0 True False False False False False False 0 insufficient_or_context_specific +P3H1 -0.409170249789807 0.0429402385443878 0.383949763302995 -0.262297313366762 0.216124531704687 0.587986868893775 0.220339507522976 0.46104734065596 -0.685108228197144 0.0163589495934024 -0.464768720674168 0.0902475606147924 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACER3 0.326380161507251 0.0429503063907429 0.383949763302995 0.282475960429514 0.0842770920626063 0.464779732481256 0.583386740464232 0.0690848837751172 2.0 -0.301690156539385 0.503388661270573 -0.215418389689363 0.562092981692175 -0.517108546228748 0.194546743898624 partial_or_other True False False False False False False 0 cross_species_direction_conflict +F12 -1.19631073157263 0.0429766128401823 0.383949763302995 -0.953058280833985 0.114071822358735 0.4924007041452 -1.20670988381147 0.0095657345050797 1.05115124606288 0.0145300686176159 -0.155558637748583 0.707464331712497 reversed False False False False False False False 0 insufficient_or_context_specific +GRK2 -0.696881732772318 0.0430207018362799 0.383949763302995 -0.654971986881666 0.0595852571983868 0.428473540531152 0.417415916227649 1.0 0.19880539370578 0.449823867490762 -0.460816918552111 0.0487575712308209 -0.262011524846331 0.262032229051348 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LMLN 0.62436030522063 0.0430846579936933 0.38411181986708 0.41743734541744 0.199610715653833 0.575263953748573 -0.881555499790885 0.129168189654652 0.257419928230086 0.617962435621337 -0.624135571560799 0.231897246435779 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FTCD -1.11289772238782 0.0431116221388985 0.38411181986708 -0.988933517607639 0.0742991631493269 0.452862231765951 -1.27048816390401 0.0074827175819708 0.799087223313203 0.044417900704021 -0.471400940590809 0.220160036890314 reversed False False False False False False False 0 insufficient_or_context_specific +TMEM9B-AS1 0.651970658048024 0.0432903760195828 0.384202635045819 0.423656292014659 0.194661639288621 0.571343735852293 0.0325325499864618 1.0 True False False False False False False 0 insufficient_or_context_specific +KDM8 -0.971926292361118 0.0433445150652788 0.384202635045819 -0.913877747834031 0.0604363941206939 0.429268745755419 0.708087524231935 0.9231442161533571 2.0 -0.633577364025002 0.269917210085298 -0.274117331985625 0.597454149922992 -0.907694696010627 0.100645832835997 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKFY1 -0.303069842332585 0.0436299451479526 0.385082844493601 -0.158251348929461 0.300055615333946 0.658405125798708 0.722788282388087 0.458406324255655 2.0 0.427748489890867 0.180964518180328 -0.0558847630983053 0.852272667605875 0.371863726792562 0.208799059757155 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABRAXAS2 -0.443291630115673 0.043632577275678 0.385082844493601 -0.221493365636771 0.317911589432456 0.669888249918929 -0.145133008123946 0.635906082439881 0.187169453071427 0.426111390509139 0.0420364449474806 0.88754738061924 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPM1K 0.670311493419377 0.0442801990003179 0.387669747231417 0.43590313437071 0.1891949779251 0.569886897607216 0.110512002408374 1.0 -0.412249641166285 0.174836620623234 0.272366279989277 0.299718864327055 -0.139883361177008 0.6351603677909 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NMT1 -0.36534570322846 0.0444651132374186 0.388950012892018 -0.322413657700167 0.0807198772966411 0.460700922547448 -0.364296846570586 0.102513978234068 0.557384429515224 0.0134065240993739 0.193087582944639 0.343362459988797 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PSD3 -0.55514323463028 0.0445271925875077 0.389170612035519 -0.312794800666505 0.265657909323278 0.62822323708046 0.300082701346527 0.594462105950531 2.0 0.297808368464534 0.213207196779859 -0.229427560906675 0.270123135747745 0.0683808075578592 0.780737509200391 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCNYL1 -0.421133298632902 0.044659217313549 0.389376026269853 -0.319645097819877 0.137036756150745 0.523456610506354 0.317087006354578 0.451047883236581 -0.788428648533728 0.036254923462592 -0.47134164217915 0.218949836641413 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPM1H -0.772920409248425 0.0447952288831252 0.389380444063995 -0.58356930008403 0.143868380429746 0.530734577420424 0.0184511679410012 0.984281153578659 -1.03876784959422 0.112565783172391 -1.02031668165322 0.157663651643468 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ILF2 -0.554906842213724 0.0448386129864759 0.389380444063995 -0.169099089828216 0.580854801205371 0.832868383733265 0.390643984294572 1.0 0.0362926193214596 0.925432867530037 -0.003954113614944 0.989521599252756 0.0323385057065155 0.920642268373684 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AAMDC 0.519786108442725 0.0450389591654402 0.389380444063995 0.334823373507679 0.202964187912906 0.576835372560841 0.0465615387669174 1.0 -0.293927274935272 0.291110380406677 0.535807759822733 0.0351412152816414 0.241880484887461 0.332646961763079 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TDP2 -0.394761864927924 0.045062128833827 0.389380444063995 -0.251689533331097 0.228478561538715 0.60038155150582 -0.346644504824652 0.303742798067613 -0.703986263636403 0.0305640136606549 -1.05063076846106 0.0081434923896468 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ENDOD1 0.727546121994564 0.0450747005702194 0.389380444063995 0.479008894220418 0.180925453965356 0.563603217043398 0.669514261917271 0.6411802528568691 2.0 -0.167951006286828 0.790594211673603 0.468949899445115 0.283105821907691 0.300998893158287 0.545436765316864 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KIAA0556 -0.314991009660219 0.0451412827746098 0.389380444063995 -0.127270963382172 0.416034502609107 0.737601948039338 False False False False False False False 0 insufficient_or_context_specific +SCN1B -0.926805770044767 0.0453126095446495 0.390539209446865 -0.439350617274817 0.368121032360641 0.708317354196916 0.992726574661543 0.0012816834328547 -0.666991070623278 0.0080477022420879 0.325735504038265 0.152128992307482 reversed False False False False False False False 0 insufficient_or_context_specific +STX3 0.527193101622557 0.0456136351438972 0.392492876812768 0.195546832148539 0.472531350439039 0.775593712997022 -0.313217732526424 0.703159281983927 -0.731282914125857 0.259657350781325 -1.04450064665228 0.149370172413192 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SP110 0.493530989802951 0.0456798560664832 0.392494538491086 0.414811356371176 0.0959137389464945 0.47569521889622 0.542648414052269 0.0905228544210543 0.0569410320465369 3.0 -0.288985872844806 0.753444349195425 -0.897332496214461 0.209434770531013 -1.18631836905927 0.135142113331727 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BOK -0.615990965012772 0.0458866752632074 0.393239868042974 -0.472564965371723 0.128042277034638 0.511104106212365 0.9476037994837071 1.0 -0.276921288043759 0.33087475188657 -0.163675679410336 0.514249519157011 -0.440596967454095 0.0973214087195158 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BDNF-AS 0.513558199707522 0.0459345699478785 0.393331053941364 0.443675774449612 0.0897529928253356 0.470746198832535 True False False False False False False 0 insufficient_or_context_specific +VIPR2 -1.0926341764604 0.0460261451258214 0.393661071168746 -0.689303190826441 0.222298884047657 0.593397884800048 False False False False False False False 0 insufficient_or_context_specific +DENND6A-AS1 0.788176873684422 0.0462769422938752 0.394215126181513 0.756939361388042 0.0567090592472949 0.424455207563489 0.0172716288950973 1.0 True False False False False False False 0 insufficient_or_context_specific +RPS3A 0.749574353757624 0.0466440135526194 0.395461683418996 0.459516433535608 0.230122497958755 0.601252301465197 True False False False False False False 0 insufficient_or_context_specific +AZI2 0.451844833389778 0.0467126377040004 0.395461683418996 0.327643576300505 0.151794077471742 0.534368029741253 0.0792442245432431 0.07255181228249 2.0 -0.121954654899208 0.68125765850255 -0.431302508955699 0.0716773886764753 -0.553257163854907 0.037480318894471 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SPHK2 -0.557617247483595 0.0467826901487332 0.395461683418996 -0.462809999670644 0.10636486181936 0.483261130274234 0.8170320782413979 0.617521476174294 2.0 -0.367125575180633 0.205791739918897 -0.0138913385266432 0.962937369670483 -0.381016913707276 0.157571229369509 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PER3 -0.754060390973469 0.0468441786129329 0.395664670236276 -0.337684246682093 0.405509468484101 0.733444811508554 1.44183955873045 0.0227809058996919 -0.927153226983557 0.0657913189709161 0.514686331746897 0.372901888528219 reversed False False False False False False False 0 insufficient_or_context_specific +MAN2A2 -0.697739148105289 0.0469997970763034 0.39634493413068 -0.502814675535517 0.156192855935955 0.539558215777 0.520124538845667 0.0508233154505026 -0.508021146051312 0.0387035899534693 0.0121033927943552 0.967167277207169 reversed False False False False False False False 0 insufficient_or_context_specific +EIF5B -0.389487351905263 0.047311322114665 0.396574544678809 -0.14266992068762 0.498905735342165 0.7899705952391 0.0449684859826814 0.905758363556087 0.0393653063636331 0.892251476317319 0.0843337923463145 0.779445547542838 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM39B -0.392069493075175 0.047370373824223 0.396574544678809 -0.29593234986907 0.1444791430524 0.532058176612221 0.489336855077692 1.0 -0.331842673742336 0.641516064201749 -0.0998176004441322 0.872919594955843 -0.431660274186469 0.477923505794725 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC23 -0.507347581678517 0.0475183104536168 0.396574544678809 -0.326046352833845 0.222217445017419 0.593397884800048 False False False False False False False 0 insufficient_or_context_specific +FARP1 -0.499010093593707 0.0477583931777527 0.396735650076082 -0.329421731654337 0.196889724701087 0.571879675616801 -0.262428260649078 0.337734825671819 -0.290261648714234 0.221054478542104 -0.552689909363311 0.0396757426500509 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TENT4B -0.326404090781875 0.0477691096834768 0.396735650076082 -0.173812802678657 0.292686929785723 0.651509781962399 0.3932139651648971 1.0 0.269110863679686 0.487696580024284 0.0149524096231836 0.966369504880937 0.28406327330287 0.401896487236387 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FGF14 -1.02718930866914 0.0477873585296751 0.396735650076082 -0.680875460591448 0.203157331227119 0.576835372560841 0.4418425083982921 0.230924939799062 2.0 False False False False False False False 0 insufficient_or_context_specific +ZNF587 -0.34358398236587 0.0478149156414936 0.396735650076082 -0.160051053084342 0.379562334875304 0.716424065042321 False False False False False False False 0 insufficient_or_context_specific +GPAT4 -0.545058279796517 0.047853281517277 0.396735650076082 -0.526946927405761 0.05721936089322 0.424455207563489 -0.470689241973418 0.278583503408597 0.1583064237912 0.692737677720338 -0.312382818182219 0.434162253086943 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPN12 0.402075372984566 0.0478858098412775 0.396735650076082 0.117234804001649 0.563395769823743 0.823754286312897 -0.122979321688751 0.64876414120596 -0.0789279288857186 0.724867048404529 -0.201907250574469 0.369851601721905 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DPYD-AS1 0.616227925604772 0.0482743845571923 0.396735650076082 0.366571231795379 0.233352937901825 0.602697571243329 True False False False False False False 0 insufficient_or_context_specific +CDC37L1 0.576887583073776 0.0483675426826849 0.396735650076082 0.51643664080957 0.0801833403885565 0.4602604817535 0.875252024952192 0.0924699907738156 2.0 -0.177440130636423 0.477976650306275 -0.114072707458153 0.594845287939125 -0.291512838094576 0.184314161126339 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TYK2 -0.420321057064597 0.0483676685257392 0.396735650076082 -0.394268152085908 0.0650573880635449 0.435400968200579 0.341830010595211 1.0 0.0589258591352164 0.884071215441952 -0.59322727953859 0.0439378087065328 -0.534301420403374 0.0854552494099238 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM30A 0.438906578959465 0.0484822599173758 0.396735650076082 0.424940167010431 0.0570564234020547 0.424455207563489 0.5345676965657971 1.0 -0.0511211101914743 0.917654029442355 0.493887258277102 0.13316453709146 0.442766148085627 0.201126124534387 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TOP1 0.312780215224922 0.0486620215163685 0.397042985448082 0.294599502779815 0.0641601987754413 0.433610060260339 0.448239500155835 0.8060920784325841 0.0959924029997035 3.0 -0.356315555467714 0.15820560140965 0.425530052177711 0.063925160738776 0.0692144967099969 0.787599022017731 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LRRC37B 0.429632172279854 0.0487658571799586 0.397276172921298 0.226425962006411 0.306756345319071 0.661696690217148 0.8640619467599321 1.0 True False False False False False False 0 insufficient_or_context_specific +ITM2B 0.437182266495387 0.0489069767070697 0.398118627658629 0.394984439216067 0.0747390326501956 0.452862231765951 0.302519385662716 1.0 -0.347693935214933 0.393845839332733 0.512239341276361 0.148635614820605 0.164545406061428 0.673960659682735 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ATP5F1A -0.410519447066565 0.0492371929223504 0.399082619839385 -0.337440163329398 0.111031897489251 0.488819418659101 False False False False False False False 0 insufficient_or_context_specific +YPEL2 0.575399505637641 0.0494441870590774 0.399082619839385 0.415046865935792 0.165015633998224 0.545094551255265 0.48944368407092 0.139172068692141 0.160626295680619 3.0 -0.199613859258541 0.604968023577395 -0.329561680167691 0.284618012646965 -0.529175539426232 0.114338131452238 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AFAP1L2 -1.33545432461461 0.0495012981700633 0.399082619839385 -1.15119451008082 0.0931393075819252 0.472709733823144 0.286698198882195 0.498936633070642 -0.318751587388996 0.35131430806239 -0.0320533885068016 0.941142242357347 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIPR1 -0.498829191251704 0.049517826678102 0.399082619839385 -0.417895081274729 0.105897899057415 0.483261130274234 0.426737460792897 0.16366287121192 -0.536661955121196 0.0512142907061638 -0.109924494328299 0.727281137768212 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF345 0.57879022192457 0.0496201359894085 0.399082619839385 0.390808165936593 0.188344025288452 0.56929178900529 0.3266870289574 1.0 True False False False False False False 0 insufficient_or_context_specific +GLB1 -0.343850922394021 0.049647631282857 0.399082619839385 -0.0797816541059958 0.64604202718501 0.867469378483955 0.253701063279044 0.500662008062218 0.10078675226904 0.746711467176359 0.354487815548084 0.2767083651191 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IRS2 1.03808669856244 0.0496577269408936 0.399082619839385 0.75379845952609 0.157135069640654 0.540577408037155 0.799169592409688 0.75057796159176 2.0 -0.729877663955439 0.0541646986342291 0.607205228066652 0.0698619777595799 -0.122672435888787 0.73802272891703 reversed True False False False False False False 0 cross_species_direction_conflict +ATP9A 0.60455426814288 0.0497568101531302 0.399082619839385 0.231879714842804 0.445507924290587 0.760927015161427 0.0432662811365253 1.0 -0.245852009702298 0.303350793900669 0.382945774632911 0.0723127075576608 0.137093764930613 0.540485445531245 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MDM1 -0.586025929028438 0.0498951337423813 0.399082619839385 -0.526669740660685 0.0810524691409084 0.461068439742811 1.00727915731002 0.0625182612187812 -1.19988690210966 0.0154742191171605 -0.192607744799641 0.746915894703652 reversed False False False False False False False 0 insufficient_or_context_specific +WSB2 -0.399328447567744 0.0499827500679232 0.399082619839385 -0.34907658798062 0.0919342982445491 0.472460751419842 0.629629678689145 0.502758334796927 2.0 0.250249830256177 0.371076058725012 -0.45082977861594 0.0656821443845817 -0.200579948359763 0.434833800585178 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC65 0.860868583408693 0.0500197208874768 0.399082619839385 0.826554776708448 0.0616263565155656 0.430894749729366 0.0275674588723335 1.0 True False False False False False False 0 insufficient_or_context_specific +CTBS 0.489976298700181 0.0500834247613806 0.399082619839385 0.34046099236008 0.182287670924186 0.56456240235188 0.023490311205123 1.0 -0.0261679085465135 0.95834264814358 -0.0886801048704799 0.804491446852078 -0.114848013416993 0.77698947081037 partial_or_other True False False False False False False 0 cross_species_direction_conflict +STAG2 0.287934875616249 0.0501032280365924 0.399082619839385 0.115597330327204 0.429582403139286 0.74852333689201 -0.174734721637701 0.564274375022974 0.354946412459734 0.141654435447897 0.180211690822033 0.489381313893369 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL109930.1 0.872981041283887 0.0501998683684635 0.399082619839385 1.00935889296661 0.0245269884207352 0.349408136686844 0.0262348645596525 1.0 True False False False False False False 0 insufficient_or_context_specific +CCDC59 0.665876563395792 0.0502179906998223 0.399082619839385 0.582417144781413 0.0881525899055523 0.468622105620855 0.0353411368723771 1.0 -0.14298630886675 0.570333397214886 -0.28189293902031 0.167806790823406 -0.42487924788706 0.0607086442084818 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CTDSPL 0.521539677189009 0.0502380713691499 0.399082619839385 0.332982829582683 0.216435569798712 0.588192212595831 -0.153218823284606 0.621686985008991 0.173034577752567 0.477456438708268 0.0198157544679611 0.947742359893248 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL669831.5 -0.44466532386917 0.0502577105208654 0.399082619839385 -0.345267623412447 0.14005135384133 0.525466309117542 False False False False False False False 0 insufficient_or_context_specific +TNIP2 -0.488223984334279 0.050259898378733 0.399082619839385 -0.25899894396192 0.292915348561403 0.651509781962399 0.274987920002032 1.0 -0.0555577184261162 0.910703268238692 -0.815257279860543 0.0290237123958372 -0.870814998286659 0.0286396896992657 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HEMK1 -0.48062134847478 0.0503310697965078 0.399082619839385 -0.361560611120112 0.156654029225484 0.539558215777 0.183980878826634 0.622690304209923 -0.896883052648919 0.0106330402300301 -0.712902173822284 0.0433232706511173 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AIG1 -0.50522283307296 0.0503413877884316 0.399082619839385 -0.321106425094004 0.227548954534242 0.599715891655649 0.290802532907219 1.0 -0.332807200865906 0.514073540290151 0.186968898275903 0.655036528161175 -0.145838302590003 0.761824381942425 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TUBGCP4 0.510060212829213 0.050460467047538 0.399671126097454 0.0485377281700313 0.862025358344656 0.957822965712685 -0.307293746478995 0.318003699851839 -0.230629263021888 0.383395069845939 -0.537923009500883 0.0677603951054493 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ADGRA3 -0.687301282026765 0.0506196943867885 0.400194727078426 -0.814291219889706 0.0179275408508023 0.32629129734252 -0.0558770970843289 0.86559101648086 0.308371595168959 0.174404667935464 0.25249449808463 0.294212716086033 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COL27A1 -0.60867307814046 0.0506402874954325 0.400194727078426 -0.833770895183442 0.0052230837811033 0.265121723850427 0.867110276117968 1.0 -0.136727863028986 0.671045748925689 0.014181444188094 0.961783031422977 -0.122546418840892 0.664776110487574 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RYK 0.394453719689065 0.0506843102232362 0.400243042136819 0.402920474745568 0.0454516890529538 0.395939713713768 0.0875388148284182 0.076816046311703 2.0 -0.214693483256904 0.516877879577924 0.40465235455769 0.141615006654009 0.189958871300787 0.516803625969098 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BICD1 0.731318898467571 0.0507750543433105 0.400440346479357 1.1145174098154 0.0021902466146079 0.223491901031981 0.854594037565278 0.352262569407299 0.275804122112874 3.0 -0.748134338808546 0.363435743235107 0.439492218588283 0.529590490002352 -0.308642120220264 0.693373898775928 partial_or_other True False False False False False False 0 cross_species_direction_conflict +VKORC1L1 -0.334107768928476 0.0507995853922013 0.400440346479357 -0.319591011676118 0.0632836025241242 0.432999502601999 0.0575386729375817 0.901302941958943 0.403821643850175 0.176102531944332 0.461360316787756 0.160030020462739 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRP1B -1.08337572844935 0.0508323024360817 0.400440346479357 -0.414853510227429 0.454282711775362 0.765695541335292 False False False False False False False 0 insufficient_or_context_specific +TATDN3 0.737784733547881 0.0509004929677965 0.400440346479357 0.589883035194744 0.114145570984249 0.4924007041452 0.0193321817082731 1.0 True False False False False False False 0 insufficient_or_context_specific +HDLBP -0.278337322077866 0.0509469832463959 0.400440346479357 -0.235525766873588 0.10294032848502 0.479239170340314 0.554503510041526 1.0 -0.0449790459285846 0.915993062050496 0.352492317030589 0.220997882653384 0.307513271102005 0.308324955318486 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF337 0.365362003947662 0.0509747893226232 0.400440346479357 0.055038963071584 0.782561864837517 0.924647355053618 True False False False False False False 0 insufficient_or_context_specific +ZNF83 0.35863667218418 0.0511424846695151 0.401134171693403 0.360152113472393 0.0498493513839025 0.40534943521819 0.7594176217913701 1.0 True False False False False False False 0 insufficient_or_context_specific +PNPO -0.815541629154883 0.0511808585094012 0.401134171693403 -0.496273124301085 0.262264052294606 0.625138701483784 -0.479631734178011 0.0855968139276513 0.523743920926851 0.0442960685443084 0.0441121867488405 0.882160573064927 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP1R21 0.540192885029825 0.051215084622344 0.401134171693403 0.371274020638559 0.188617377814338 0.569351952070621 0.0731674935435827 0.0939000936510256 0.0886335922471451 3.0 -0.423073225322633 0.212181780318667 -0.237355019978213 0.425803806110569 -0.660428245300846 0.0488444194118792 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AMFR -0.373297589808973 0.0513498346945314 0.401629751193748 -0.219233655476306 0.267575022094603 0.631015654070766 -0.31928233634472 0.351904279935357 0.372738824272425 0.207515158358419 0.0534564879277053 0.882160573064927 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP6V0D1 -0.501495701385666 0.0513960363280481 0.401657551111423 -0.545141934416936 0.0332524538272292 0.376280667109215 0.116726638207616 0.719214521019672 0.31006482374388 0.206753689213225 0.426791461951496 0.109989387135437 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTPBP4 -0.597742995326522 0.0515860813359659 0.40281800880409 -0.306601623547305 0.323768477381952 0.673698774970171 -0.178489265663067 0.659394739618876 -0.112295834355991 0.738981478898089 -0.290785100019058 0.38708650077344 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM3 -0.547692214142821 0.0516208340511398 0.40281800880409 -0.548748147532902 0.051107400080184 0.40964799201548 0.498151398633712 0.203851356480766 -1.30517068804758 0.0040561496636273 -0.807019289413866 0.0480084019251343 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC104596.1 0.63034387349666 0.0517214369667965 0.402875896332052 0.177459765596018 0.605373908357679 0.846561288005347 True False False False False False False 0 insufficient_or_context_specific +AC104041.1 1.03174201918106 0.0517808857096604 0.402875896332052 1.08872685642699 0.0407482335478031 0.385847398921709 0.114424006118631 1.0 True False False False False False False 0 insufficient_or_context_specific +SCARB2 0.377817252589801 0.051824363851305 0.402917255922002 0.331462551225196 0.0930257893713267 0.472709733823144 1.07383223761414 0.0637624147321993 0.0851247010010574 3.0 -0.361225834573268 0.187772140621415 0.580793757003623 0.0287847860091528 0.219567922430354 0.384883045253568 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KIRREL3-AS1 0.950469677833293 0.0519105804993161 0.403142939875671 0.411973486282763 0.386489418334949 0.720477739899883 True False False False False False False 0 insufficient_or_context_specific +AC022098.1 -0.450742197636302 0.0520267300981018 0.403302655195124 -0.579848175408288 0.0117533713370812 0.305645553145081 False False False False False False False 0 insufficient_or_context_specific +PYROXD1 0.479946762568923 0.0525086052826311 0.406035451125819 0.305429999368675 0.232723654941773 0.602604162857471 0.0320602515205109 1.0 -0.172433342705842 0.726514481255491 -0.601881943909802 0.116115116528055 -0.774315286615645 0.0709873582963911 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MTUS2 -0.680350920610866 0.0525138159334871 0.406035451125819 -0.611335981939847 0.087134295049209 0.468303538747472 0.9193813036443379 0.0123430785056804 2.0 2.24113852580683 0.0008783339103131 -1.47559300795539 0.0033471189363927 0.765545517851442 0.149853670307847 reversed False False False False False False False 0 insufficient_or_context_specific +BCOR -0.356038336543376 0.0525239144797304 0.406035451125819 -0.27957783061023 0.144965891837172 0.532658823056677 0.304049613270253 1.0 0.474095974724046 0.196997217755025 0.0615962137419201 0.853771780220125 0.535692188465966 0.118941592988843 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MANEA 0.614553849923845 0.052546326536916 0.406035451125819 0.338782867596054 0.288002938498395 0.648258530618693 0.0129278835997415 1.0 -0.0909352033647936 0.868900513081839 0.356768680384699 0.308077333104169 0.265833477019905 0.511308110634057 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ASPN 0.634004172074914 0.0528287552521705 0.406035451125819 0.598414957047364 0.0685371069204084 0.438244764077482 0.827504756946297 0.0834118638008461 2.0 True False False False False False False 0 insufficient_or_context_specific +STON1-GTF2A1L 1.00737445343758 0.0528422183513579 0.406035451125819 1.15616915704775 0.0263516062474761 0.354273049744177 0.12483889416853 1.0 True False False False False False False 0 insufficient_or_context_specific +F13B -1.17505942855576 0.052852720098512 0.406035451125819 -1.21666282767869 0.0450321300211426 0.393909882985272 -0.709452842036878 0.200608955311979 1.16125559105432 0.0274208226545536 0.451802749017445 0.364011360670613 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASCC2 -0.452997520526262 0.0528769070236404 0.406035451125819 -0.380947455208592 0.107814863772319 0.483943630910814 -0.129942668210131 0.636953254160139 -0.21349812252086 0.322285455025229 -0.343440790730991 0.141586121341452 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RASSF7 -1.35633368094367 0.0529018469179948 0.406035451125819 -1.42215053512287 0.0405635472295899 0.385481486633673 -0.560190748228904 0.228906539564551 0.138194107316786 0.748929995763686 -0.421996640912118 0.322278357577785 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SARAF 0.536673839487539 0.0529176719785117 0.406035451125819 0.21901341384376 0.418570412148357 0.740369645076621 -0.480279800353274 0.124392099311252 0.612721774470767 0.0389870773095688 0.132441974117493 0.666043360827916 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KLHL22 -0.31974248204003 0.0529927600999823 0.406051142758397 -0.34233776225036 0.0357399264224333 0.37720666979567 0.418614302635369 0.102155541429174 -0.422032869294787 0.064164001723113 -0.0034185666594183 0.990657973152916 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COQ8B -0.561892585445419 0.0529966352264701 0.406051142758397 -0.642741113466654 0.0228730345078022 0.346028040476539 0.503815613229235 1.0 0.126029377639689 0.735809641856386 -0.698289340584744 0.0261433812600676 -0.572259962945055 0.0744816850310167 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BNIP3 0.808606897575225 0.0530797993632638 0.40614004939973 0.8172128429052 0.0509376796445445 0.40897340052251 0.104222920414014 1.0 -1.20288890507169 0.0396203662550047 0.95607362971613 0.0619093351571781 -0.246815275355561 0.639678470514628 reversed True False False False False False False 0 cross_species_direction_conflict +LINC00486 -0.415116479643968 0.0531339853593683 0.40614004939973 -0.518616322085884 0.0110024997849758 0.302570357129259 False False False False False False False 0 insufficient_or_context_specific +FAM135A 0.305229257461739 0.0532439962632734 0.40647152028029 0.439302268160232 0.0038002511624231 0.243764662040058 -0.187987766193732 0.595763570980941 -0.765074687887152 0.0191307007918135 -0.953062454080884 0.0108387751714437 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WASF1 0.464010805896504 0.0532886702980493 0.40651862789509 0.594061287735911 0.0126286270980728 0.313114831651016 0.127398467877202 1.0 -0.432907264068869 0.368803594259381 -1.16998409070971 0.0200904263752187 -1.60289135477858 0.008154497343468 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SPOUT1 -0.893661728985692 0.053410856285661 0.407156549215891 -0.671087799995735 0.16306985226026 0.544298760692042 -0.0731670355902038 0.848726472302442 -0.476527056244569 0.0853227920294281 -0.549694091834772 0.0676701997856136 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEC22A 0.395364301035629 0.0535281083749512 0.407607254258146 0.341228832935017 0.0981474720066991 0.478125555523304 0.0616485878934257 1.0 -0.0088223393070501 0.980581669633894 0.0464182585632665 0.860572872025497 0.0375959192562164 0.899631576194502 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CLOCK 0.338831623243064 0.0535977610382346 0.407698242825418 0.271957484652488 0.132053512582772 0.518314929773221 0.26501113822612 1.0 -0.273239537350156 0.361567364079523 0.101254690115603 0.70253735652379 -0.171984847234552 0.536588622562443 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DCAF1 -0.531726195169884 0.0537561846993083 0.408608925885743 -0.479507472402885 0.0848612468599101 0.465302662671366 0.107102066930484 0.784776473523065 0.102037391459312 0.725822437496312 0.209139458389796 0.502494825490761 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYTOR -0.780555899131903 0.0538164308532768 0.408664790298725 -0.22969820465581 0.539583756233214 0.812783927483158 False False False False False False False 0 insufficient_or_context_specific +AGXT -1.07953579765793 0.0538409474621639 0.408664790298725 -0.900680927928523 0.114156311913568 0.4924007041452 -1.69057220150911 0.0030551538304764 1.81293103960432 0.0021551896597206 0.12235883809521 0.791591606646755 reversed False False False False False False False 0 insufficient_or_context_specific +GATAD2A -0.404206186866174 0.053904107160707 0.408770140133979 -0.290026550638898 0.172746502520847 0.553858965567902 0.4782361083889 1.0 -0.244176587141194 0.287240782454071 0.0207040899508427 0.929350818843529 -0.223472497190351 0.284835833550179 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STK25 -0.63320087040353 0.0540264338031552 0.408770140133979 -0.430857149350364 0.203182428290673 0.576835372560841 0.657320752191598 1.0 -0.0974580885417162 0.75873333857183 -0.50385059832573 0.0486937789410132 -0.601308686867446 0.0303524188451113 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RHPN2 -0.884400712055393 0.0540630704732035 0.408770140133979 -0.911732767419064 0.0469144458250258 0.399450754777127 -1.06033117958051 0.05198712853848 0.413422184050313 0.374760985990205 -0.646908995530193 0.177904366749501 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HDGFL2 -0.456778296383207 0.0541835484183184 0.408770140133979 -0.494812541265642 0.0343182381476993 0.37720666979567 -0.330684594028361 0.230116813065802 -0.382512727616288 0.120964807049878 -0.713197321644649 0.0172648698473128 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR33 -0.257915410600011 0.0542131301571191 0.408770140133979 -0.30549798257798 0.0182177313596357 0.32629129734252 -0.019377686206042 0.960760068523928 -0.412549300383859 0.130998981317865 -0.431926986589901 0.133211599195718 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCNK1 0.830335991900517 0.0542567170411002 0.408770140133979 0.575682463682164 0.18813683994534 0.56929178900529 0.105427948862864 0.0357628099838914 2.0 True False False False False False False 0 insufficient_or_context_specific +ACOX2 -0.851587704355983 0.0542807100272626 0.408770140133979 -0.913676255104117 0.0376037404668912 0.379484931484566 -0.933569538388152 0.0221206054104173 1.02870838835569 0.0107235498676064 0.095138849967537 0.808485507146992 reversed False False False False False False False 0 insufficient_or_context_specific +SNHG22 0.452664730838053 0.0543202620619805 0.408776426835631 0.107890272581335 0.62917848413513 0.85847330518205 True False False False False False False 0 insufficient_or_context_specific +TMEM267 0.468285570099985 0.0544906331748911 0.409273866469641 0.276866201701427 0.258240242455174 0.622136927842961 -0.37906877023557 0.364396958298434 0.546410263274253 0.107640497622777 0.167341493038683 0.667266329834856 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF592 -0.337339737826528 0.0545026573457393 0.409273866469641 -0.282895891213597 0.114746415210295 0.492613299848511 False False False False False False False 0 insufficient_or_context_specific +OSBPL7 -0.660215077556352 0.0546798076483299 0.410312302168491 -0.603459086748183 0.0826572610201549 0.463430311267398 0.384137727745868 0.532893532101164 -0.472636774830368 0.311836365887141 -0.0884990470844993 0.890860129187018 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TPD52L2 -0.444305862859336 0.0547421397724086 0.410488289571797 -0.487427370944523 0.03116500717003 0.375031405408838 -0.0284008514702637 0.941110137041743 0.400463417884502 0.12312561872869 0.372062566414239 0.172516762636239 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC36 0.610682165829396 0.0548561677053311 0.411051397184447 0.378571699671747 0.243254736725255 0.609898739043611 0.718916722487127 1.0 True False False False False False False 0 insufficient_or_context_specific +RIPOR3 -0.723344536710369 0.0550734820764575 0.412387109051942 -0.679028436416378 0.0747037719151306 0.452862231765951 -0.360332196520262 0.45867650525603 -0.746833828184072 0.080304860507502 -1.10716602470433 0.0238621642159009 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF480 0.526798504055595 0.055154289456304 0.412699495449793 0.366402178183763 0.191266297178912 0.570403483290424 True False False False False False False 0 insufficient_or_context_specific +AL356258.1 1.24428859804018 0.0552333056250855 0.412799138369557 0.922502663184803 0.149002617330456 0.533583468169136 0.022409072116963 1.0 True False False False False False False 0 insufficient_or_context_specific +CHD8 -0.366597394257248 0.0552862849578531 0.412799138369557 -0.354197346130863 0.0654566394708211 0.435533238803682 -0.133915845743153 0.621686985008991 0.164234552251585 0.443482406252529 0.0303187065084313 0.910406396753138 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP1B1-AS1 0.738295018852339 0.055296262601413 0.412799138369557 0.90562846562384 0.017331864129556 0.326204572615871 0.9475220539869201 0.9075152245875769 0.122626992923884 3.0 True False False False False False False 0 insufficient_or_context_specific +STK40 -0.493996670346782 0.0553239989385228 0.412799138369557 -0.414130139344378 0.11034794785337 0.487310613989892 0.237509507103407 0.3506445942526989 2.0 -0.157969004267678 0.505374658311079 -0.0852959018616823 0.677585067137296 -0.24326490612936 0.236334419408948 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ST3GAL2 -0.605623979090915 0.0554481640266764 0.412850293225423 -0.523923894238688 0.101682881637173 0.478843828869436 0.280716763010763 1.0 -0.0855751910609972 0.848916865927497 0.0369268883524736 0.916891833145961 -0.0486483027085236 0.900097135611324 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KDM6B -0.745745704818809 0.0556440118567033 0.41343383218895 -0.768590692793355 0.047912004657281 0.401952804329389 0.321272864650792 1.0 -0.0608988523496456 0.859070568791721 -0.518138727079917 0.0448964269779097 -0.579037579429563 0.0361876332955558 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALPK1 0.365898250017591 0.0556571835658259 0.41343383218895 0.407739347170822 0.0302874532194514 0.374450197630696 0.116699462968197 0.0927036343303801 2.0 -0.223156395496919 0.645702577553322 -0.0808040594106939 0.848838771797295 -0.303960454907613 0.457227563198328 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SRRT -0.583985495940885 0.0557492673086353 0.413633706426263 -0.733658352151201 0.0103392814937988 0.302245517751671 0.370416766005094 1.0 -0.0148345644860934 0.966171256828655 -0.485817358499005 0.0564881968967993 -0.500651922985098 0.0607086442084818 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CRELD1 0.666088895674868 0.0558943832485337 0.414419170181193 0.342032722535731 0.322231379905212 0.672877524535327 -0.440772524058817 0.0877731535226751 0.0052319264326207 0.985243492481549 -0.435540597626197 0.0772461452548582 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GRB14 -0.964453620518435 0.0559799583363619 0.414762386045831 -1.03902760298266 0.03838072079732 0.379484931484566 -0.468784909908461 0.286084384898412 0.50950150963533 0.171997877642175 0.0407165997268692 0.92923636652208 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAMK4 -1.39614015132358 0.0560713243724071 0.414864827864203 -0.986118771884031 0.18008595055352 0.563028565574197 False False False False False False False 0 insufficient_or_context_specific +GJB1 -0.779370389665539 0.0561014222787466 0.414864827864203 -0.40590899921044 0.35369030334915 0.697398977158885 0.255192125226028 1.0 -0.962934711418129 0.0674388078975907 0.899907294308748 0.0628258187193038 -0.0630274171093816 0.911441788670867 reversed False False False False False False False 0 insufficient_or_context_specific +PHF20L1 -0.325555722911604 0.0561509603161532 0.414864827864203 -0.250704265617613 0.156729562950666 0.539558215777 0.31258454921805 1.0 -0.189612598059632 0.411319061090943 -0.425709734598478 0.0430815038154972 -0.61532233265811 0.0132316467429353 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ENTPD1-AS1 0.363531662851064 0.0562646716278686 0.415221934055562 0.308534105167268 0.106749340203197 0.483261130274234 0.0872612750551862 0.0853843022119764 2.0 True False False False False False False 0 insufficient_or_context_specific +STAB1 -1.30333920334069 0.0563307224998219 0.415221934055562 -1.42782856942858 0.0339723883350349 0.376543096535729 0.8625193128957049 1.0 -0.103850670914129 0.806638059482639 -0.271510736238216 0.375591533282856 -0.375361407152345 0.247597157603853 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LSG1 -0.525906419757668 0.0563850000606334 0.415221934055562 -0.403390671201623 0.151395503675278 0.534235871592109 0.4820811479717479 0.8625378948882281 2.0 -0.113839503849066 0.783657599834408 -0.209615012769526 0.492849499987734 -0.323454516618592 0.320489109307081 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APOA2 0.863196244552959 0.0563954368413212 0.415221934055562 1.34605733140102 0.0022277032423277 0.223491901031981 -1.21994510611254 0.0842333672467997 1.88033615709038 0.011802185034569 0.660391050977838 0.30494807298204 reversed True False False False False False False 0 cross_species_direction_conflict +ADCY5 -0.668247023813986 0.0563959323201057 0.415221934055562 -0.639410255392476 0.0695461447364251 0.441118118691429 -0.184536360418853 0.625329340374314 -0.32956989789414 0.270123135747745 -0.514106258312993 0.114382032462266 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C9ORF153 0.745134187523037 0.0565533712943265 0.415402171315878 0.864109571205408 0.0297927840389666 0.371448754340933 0.0434402221049767 1.0 True False False False False False False 0 insufficient_or_context_specific +DCHS2 -1.4124098401214 0.0566897913006051 0.415402171315878 -1.00109224443764 0.188771178788583 0.569351952070621 False False False False False False False 0 insufficient_or_context_specific +AC126283.2 -0.897622418529629 0.0567243766638123 0.415402171315878 -0.858852511918872 0.070059056759963 0.442130018691984 False False False False False False False 0 insufficient_or_context_specific +JAK2 0.545809191164818 0.0567429088680217 0.415402171315878 0.261119434397523 0.375603399871758 0.713241132346407 0.8769658341100842 0.143530011046667 0.111889784711445 3.0 -0.349606560849705 0.443221884800799 -0.0339644231222551 0.939401800498909 -0.38357098397196 0.340894231797418 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FANCL -0.438373138884337 0.0567436999245637 0.415402171315878 -0.32888245437768 0.160725103778278 0.543541307772207 -0.239668334841474 0.624872581741088 -0.148769424329625 0.706737135288008 -0.388437759171099 0.349797314574873 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB11B -0.587750684908393 0.0567745153635927 0.415402171315878 -0.503428566945852 0.10625008501129 0.483261130274234 0.0702964602538141 1.0 0.0535879055128855 0.908962427906205 0.394850542955394 0.202856514947646 0.448438448468279 0.177904366749501 partial_or_other False False False False False False False 0 insufficient_or_context_specific +REXO4 -0.487611392545953 0.0568352916892373 0.415558870952193 -0.431900079967126 0.0960131191009515 0.47569521889622 -0.0626375644612705 0.855224142933824 -0.499089736360113 0.0503768674322141 -0.561727300821383 0.0405196423106954 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WFDC1 -0.902522388105604 0.0569686452325751 0.416219345329012 -1.10951123183086 0.016649116932374 0.325489753822016 0.322403303393216 1.0 -0.516363367165627 0.0636226328770745 0.890116534759421 0.0043411408218517 0.373753167593793 0.139517220109242 reversed False False False False False False False 0 insufficient_or_context_specific +TOGARAM2 1.26965297466122 0.0570103279722256 0.416219345329012 0.959798450562782 0.145502964532593 0.532658823056677 0.439428919862712 0.0507762051650616 2.0 True False False False False False False 0 insufficient_or_context_specific +MDFIC 0.526389572301032 0.0570438901961622 0.416219345329012 0.719620955933713 0.0061957171192416 0.27151085227822 0.702783114992113 0.0808039135483044 2.0 -0.115904462785263 0.677860015872792 -0.376975880840376 0.0900697290073849 -0.492880343625639 0.0454164544895705 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MT-ND2 -0.469093503992965 0.0571457441362562 0.416395335762727 -0.477257585113413 0.0524730401408063 0.414989032064894 -1.11119501060138 0.0369546052215028 0.985443454784142 0.0436718087936593 -0.125751555817239 0.811736477282577 reversed False False False False False False False 0 insufficient_or_context_specific +BBS4 0.346335382853038 0.0572255917234041 0.416681239597035 0.339139172850331 0.0623100204503685 0.431813959784778 0.0493103152809632 1.0 -1.26302514819143 0.0920718000202411 0.675180855982573 0.290603269257442 -0.587844292208854 0.36167345898242 reversed True False False False False False False 0 cross_species_direction_conflict +CEP44 0.405014553987218 0.0573759439147916 0.41748808811328 0.392283375073912 0.0662356230795038 0.436071024157137 0.8693709379803459 1.0 -0.420671512657145 0.164249070030291 -0.49225149256364 0.0765528040091499 -0.912923005220786 0.0097647150420757 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RARS2 0.336527283471245 0.0574684380585613 0.417554234069462 0.416106584032264 0.0163587277082514 0.325244142514861 0.052423185341406 1.0 -0.0852676311309294 0.863770414630568 -0.20275904856704 0.557420024874147 -0.28802667969797 0.441341578591295 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TAF12 -0.441840864796044 0.0574922677368329 0.417554234069462 -0.158437223688688 0.523798417778187 0.80370058056999 0.226825373509704 0.439255851898591 0.0356004942927691 0.895765884535353 0.262425867802473 0.310609426258051 partial_or_other False False False False False False False 0 insufficient_or_context_specific +THRAP3 -0.255301883269692 0.0575036802743889 0.417554234069462 -0.117396694021608 0.393075379840168 0.725225989961407 0.268137454629224 1.0 -0.124566205630304 0.619597770317579 -0.396193078825697 0.0598472749921972 -0.520759284456001 0.0276126768019347 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OLMALINC -0.748738042585478 0.0576051883420907 0.418003834031473 -0.93242577368052 0.0165293618326816 0.325489753822016 False False False False False False False 0 insufficient_or_context_specific +C1ORF52 0.336581352259699 0.0576717039930857 0.418156600495944 0.269468658875233 0.132280715777128 0.518682589655195 0.284074246154411 1.0 True False False False False False False 0 insufficient_or_context_specific +KMT2E 0.332431659860753 0.0578989107774789 0.41821964730729 0.305343250011771 0.082430026180284 0.462431570888118 0.102474003075306 0.0894113166798656 2.0 -0.272539346135191 0.309417847454037 -0.13275709352704 0.576094170015707 -0.405296439662231 0.104107005390769 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DDX3X 0.441475199333241 0.0579470673979958 0.41821964730729 0.320447364604643 0.179650537923451 0.562759923872656 0.0567233093182582 1.0 -0.0330135990535643 0.919058541659912 0.174162928182996 0.432037935551611 0.141149329129432 0.5572780050764 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF318 -0.371203381720332 0.0580891865211295 0.41821964730729 -0.33296854092123 0.0897182065267067 0.470746198832535 False False False False False False False 0 insufficient_or_context_specific +SMPD4 -0.388049548823505 0.0581127953872937 0.41821964730729 -0.450798168141022 0.0229049222991671 0.346028040476539 0.221415449671036 0.502702675908986 -0.402632679984665 0.134018799640903 -0.181217230313629 0.548281510528002 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM66D 1.10341422783271 0.0581184426218589 0.41821964730729 0.960222488257276 0.0997637929523445 0.478125555523304 0.0841268604632069 1.0 True False False False False False False 0 insufficient_or_context_specific +PHPT1 -0.7849894852816 0.0581498808720497 0.41821964730729 -0.70476734072601 0.0942655899643004 0.474102577239623 0.370179805654739 1.0 0.632887970549071 0.227935884683899 -0.51464289647757 0.214870617540116 0.118245074071501 0.836487084511111 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC38A1 0.842655004794638 0.0582694855417992 0.41831372574599 0.686445330464234 0.121304722276187 0.503433670515718 -1.07677837270237 0.33943765933819 0.368242494655134 0.715020693283466 -0.708535878047238 0.475368741299792 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AFM -1.20616949285194 0.0582756398311091 0.41831372574599 -1.34012719979815 0.0327859430945594 0.375031405408838 -0.434673723993478 0.271481559381788 -0.0536758967425652 0.894725634835289 -0.488349620736043 0.179042369312198 partial_or_other False False False False False False False 0 insufficient_or_context_specific +QPRT -0.793102872325544 0.0583180028264285 0.41831372574599 -0.622377595085083 0.143205061994821 0.529397424559285 -0.892606253783146 0.0390394328058263 0.495814280136016 0.182989245848929 -0.39679197364713 0.301908442315701 reversed False False False False False False False 0 insufficient_or_context_specific +E4F1 -0.690464876864901 0.0583569968090522 0.41831372574599 -0.681646839515257 0.0622364309729859 0.431813959784778 0.505098113570146 1.0 -0.690370231462519 0.07362329714939 0.120334107698611 0.73550808067677 -0.570036123763908 0.111553482731439 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTMR2 0.391075169071631 0.0584006849544979 0.41831372574599 0.428568495421635 0.0365597360414328 0.377876708853838 0.081576537344862 1.0 True False False False False False False 0 insufficient_or_context_specific +AL356356.1 -0.815764726355561 0.0584912854773209 0.418541503935693 -0.916071065822725 0.0307349012670068 0.375031405408838 False False False False False False False 0 insufficient_or_context_specific +AL160290.2 0.886622188501345 0.0585117692564011 0.418541503935693 0.597946284619384 0.203423605315452 0.576835372560841 0.0281752085493843 1.0 True False False False False False False 0 insufficient_or_context_specific +NPLOC4 -0.319261642289814 0.0586290654566598 0.41883004625994 -0.28611218017769 0.0925895562053372 0.472460751419842 1.11419113588632 1.0 -0.39640927066985 0.126760918126025 0.315837178254034 0.164852715955083 -0.080572092415816 0.758453016917556 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MICALL2 -0.440434954703709 0.0587635934868588 0.41883004625994 -0.377434536333089 0.109343422237728 0.485176912870447 0.152553470829873 0.7418713622749241 2.0 0.0140877316437118 0.976020105847084 -1.03895583814435 0.008171363972995 -1.02486810650064 0.0131356684860077 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CMTM7 -0.592826189526104 0.0587913422961497 0.41883004625994 -0.245684365917799 0.450210089763967 0.763947905803589 0.0898752282134986 0.798361240228936 -0.293159505406304 0.242032111735251 -0.203284277192806 0.462329437213271 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APCDD1 1.26439500112935 0.05880110383219 0.41883004625994 0.614838058393875 0.3446830864979 0.69073818751447 0.909501968835581 0.0242154837388584 2.0 True False False False False False False 0 insufficient_or_context_specific +LRRC37A2 0.549711927545481 0.0589751023145425 0.41883004625994 0.470972985596917 0.10097375718573 0.478335084675213 True False False False False False False 0 insufficient_or_context_specific +MIOS -0.442034826201884 0.0590175910773378 0.41883004625994 -0.282690671015277 0.241711484236304 0.608725035015447 0.161208848666649 0.692974096219145 -0.0843995663272231 0.796988966205911 0.0768092823394258 0.841183958032028 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIWIL4 0.746534285161917 0.0591167997144088 0.41883004625994 0.648356374337012 0.101317008546022 0.478335084675213 0.0545274795550045 1.0 True False False False False False False 0 insufficient_or_context_specific +NOL4 -1.22996421930922 0.0591471489840473 0.41883004625994 -0.938024349282133 0.156545091469806 0.539558215777 False False False False False False False 0 insufficient_or_context_specific +MAGI2 0.436424889123973 0.0591928459654782 0.41887269953319 0.469838874809307 0.0398445125976798 0.381707279248877 0.0653953917190708 0.13411408974617 2.0 True False False False False False False 0 insufficient_or_context_specific +AC018682.1 1.0953787611014 0.0592821291850324 0.419192905542751 1.3439091721974 0.0202854379394147 0.332725011651872 0.0428073859961339 1.0 True False False False False False False 0 insufficient_or_context_specific +IL11RA -0.749310330363909 0.0593179442445386 0.419192905542751 -0.661345472604049 0.0999835986318289 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +RPL10 0.488962230023395 0.0593961557070471 0.419192905542751 0.582729837927322 0.0236437000375196 0.348898908348731 0.3454029542967381 1.0 True False False False False False False 0 insufficient_or_context_specific +LCAT -0.543905058749058 0.0593969110335249 0.419192905542751 -0.302530582848736 0.32958047040187 0.678186271926176 0.602838325003125 0.5313788401545649 2.0 -0.637184575171745 0.147972068936111 0.768936940229242 0.0595388616411885 0.131752365057497 0.767577887513157 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GABPB1-AS1 0.642805079171178 0.0594798177762998 0.419497605933315 0.560058714784443 0.107546629770965 0.483778821536355 0.150596064157445 0.111795055061794 2.0 True False False False False False False 0 insufficient_or_context_specific +LPIN3 -0.626082819603374 0.0596175492763717 0.420026502238599 -0.716772444355376 0.0277223467721761 0.361795472460612 0.3425677290812331 0.4228558545024489 2.0 0.0982850513828489 0.86875336759886 -0.37796309796621 0.344131888664767 -0.279678046583361 0.545436765316864 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NIFK-AS1 0.502113669205498 0.0596741573553608 0.420026502238599 0.424315293052142 0.114537508251425 0.492613299848511 True False False False False False False 0 insufficient_or_context_specific +SETDB2 0.475025121266504 0.059745404950192 0.420176101721702 0.392541029949729 0.116489904732127 0.495128991208452 -0.898718832729976 0.160798809911724 0.302913378670803 0.600619539413559 -0.595805454059173 0.308746492536557 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DCTN5 -0.383450652102239 0.0598705448576568 0.420176101721702 -0.378667990196855 0.0631968369933042 0.432999502601999 0.546126246532133 0.156903290912026 -0.446895879354756 0.175368272180121 0.0992303671773775 0.804839246382492 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPN18 -0.559135025201916 0.0600063366783173 0.420176101721702 -0.501110244062554 0.0994536708348154 0.478125555523304 0.866765642329238 0.160718790982794 0.0205341819909466 0.968262958138958 0.887299824320184 0.123342313041514 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LAMTOR1 0.562578729686253 0.0600457259273808 0.420176101721702 0.624142660566644 0.0367150084553564 0.378182496850393 0.527904723517592 0.0221491342828752 2.0 True False False False False False False 0 insufficient_or_context_specific +MMP25-AS1 0.558323852578775 0.0600721157701843 0.420176101721702 0.189505371441428 0.527360619356037 0.804954954338736 True False False False False False False 0 insufficient_or_context_specific +ADORA2A-AS1 -0.983029745423743 0.0601106560628561 0.420176101721702 -1.11280974456328 0.0313121122945391 0.375031405408838 0.9095084374308349 1.0 False False False False False False False 0 insufficient_or_context_specific +DCC 1.02603472765683 0.0601748578530067 0.420176101721702 1.13655221167786 0.0387307674921139 0.379484931484566 0.0271893663018665 1.0 True False False False False False False 0 insufficient_or_context_specific +ITIH4 -0.989253156185955 0.0602643494485196 0.420176101721702 -0.979482942797743 0.0634304200208037 0.432999502601999 -1.67681009391228 0.0103019369675089 0.891498376501526 0.094073943655511 -0.785311717410753 0.147988958903565 reversed False False False False False False False 0 insufficient_or_context_specific +MAT1A -1.11013199660688 0.0602678198130426 0.420176101721702 -1.2126458856718 0.0396638314738072 0.381171420818022 -1.59144682036546 0.0154812465451782 1.52468182467753 0.0146965476533192 -0.0667649956879304 0.918249843470456 reversed False False False False False False False 0 insufficient_or_context_specific +ELAVL1 -0.302379025982154 0.0602814682539193 0.420176101721702 -0.282112916251871 0.0808697035388805 0.461068439742811 -0.144592437638874 0.533322688599393 0.279486309708175 0.141864410378023 0.134893872069302 0.507902925229488 partial_or_other False False False False False False False 0 insufficient_or_context_specific +THUMPD1 0.36163367357784 0.0603822544529693 0.420176101721702 0.314447236802418 0.106547993563589 0.483261130274234 -0.174508518824228 0.676859385397925 0.0358523484715041 0.923188176609816 -0.138656170352724 0.707978911791892 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TBC1D14 -0.549781769014454 0.0604264412991518 0.420176101721702 -0.66490180007446 0.0185592436825049 0.327267058068343 0.365980044485375 0.342844217215505 2.0 -0.427662124957737 0.153199985830132 -0.100824093398954 0.716170540593471 -0.528486218356691 0.0676701997856136 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRIMA1 -1.22317484723161 0.0604431635590465 0.420176101721702 -1.63745897693321 0.0047147538522426 0.261521011602645 False False False False False False False 0 insufficient_or_context_specific +DPY19L3 -0.359601459536259 0.0604440424207384 0.420176101721702 -0.18807385656939 0.349806785123296 0.694482895323762 0.0580105493688182 0.931695832894386 0.70044070178112 0.0812557516676652 0.758451251149938 0.100146930181884 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MCM3AP -0.365839975118179 0.0605240332502792 0.420176101721702 -0.366261806681621 0.0598745455816486 0.428473540531152 0.24661383843762 0.642597649597255 0.204679143943032 0.588824226499304 0.451292982380652 0.298905580034888 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IKBKG -0.839381035544357 0.060537689578586 0.420176101721702 -0.755511179068825 0.0961356191570705 0.475855540112682 -0.403776414462594 0.0962020820874513 0.0800648128391441 0.721828882346313 -0.32371160162345 0.150042198220689 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP002336.2 0.767328735698218 0.0605530610427573 0.420176101721702 0.664923282916488 0.105151710506663 0.482830329046451 True False False False False False False 0 insufficient_or_context_specific +NCL -0.418173067781151 0.0605709440064813 0.420176101721702 -0.555715749632077 0.0086329042730957 0.291509786412688 0.1729583303908 1.0 0.227711437135369 0.374201831331142 -0.0130009541119702 0.958582780498268 0.214710483023399 0.351756863086254 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC38A3 -0.881609615658033 0.0608871710887815 0.421206787747816 -0.593216374322973 0.229223878955766 0.600637150448404 -0.590835417230717 0.191346521738403 0.787820992231794 0.0611054937429738 0.196985575001077 0.656315935564366 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TENM1 -1.24226392498008 0.0608920176749247 0.421206787747816 -1.16968630332345 0.0795437554450894 0.459160525051927 False False False False False False False 0 insufficient_or_context_specific +NSMAF 0.40459940309641 0.0608931447346675 0.421206787747816 0.305542091650274 0.159469946897542 0.543271287169906 -0.271452021299182 0.465540783719518 -0.153685235431294 0.632788019765784 -0.425137256730476 0.194546743898624 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAP3K11 -0.60886689779884 0.0609718847319256 0.421206787747816 -0.799874517745027 0.0106023091491913 0.302245517751671 0.375397534841677 1.0 -0.0463901255368172 0.893521538426301 -0.277196260471222 0.241054177925544 -0.323586386008039 0.199285292614766 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF3A -0.417498913315917 0.060998785609624 0.421206787747816 -0.295748455083212 0.197418904990163 0.572466025511161 0.289531573257562 0.426696258222994 -0.591834278145511 0.0616497894244614 -0.302302704887949 0.359598793614031 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHACTR4 -0.274089077117873 0.0610976307155876 0.421613585029525 -0.314035958493529 0.0283523644472439 0.366994830293022 -0.148387533199905 0.699390873816789 0.129301349735018 0.676983969366384 -0.0190861834648866 0.958499884527045 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC12A9 -0.440499377725736 0.0612725205862574 0.4217172266138 -0.610518597016051 0.0053636467364668 0.265300960238175 0.0445928394588639 0.937235553585745 -0.474691241001708 0.205058699950501 -0.430098401542844 0.300466293054225 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPL -1.24842375781774 0.0613476440867842 0.4217172266138 -1.4019238107979 0.0317730079584789 0.375031405408838 -0.258243489620643 0.542888424064452 -0.311057796474713 0.370243743591659 -0.569301286095357 0.126102409810385 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FNTA 0.391625444910546 0.0613717244449439 0.4217172266138 0.345437559363625 0.098814229752387 0.478125555523304 -0.0005831848436035 0.998782035208483 0.182815012282797 0.484914273238182 0.182231827439194 0.527654480051495 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CDK16 -0.56075521131306 0.0613821741074336 0.4217172266138 -0.750650291818826 0.0095927896929708 0.298763048903795 0.286035627228713 1.0 -0.186618218805794 0.577921130285763 -0.518390507330739 0.0682930072377872 -0.705008726136533 0.0274442308543469 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCA8 0.441070042075084 0.0614622566196745 0.4217172266138 0.285166204545312 0.243135656951347 0.609898739043611 1.29906557191115 1.0 True False False False False False False 0 insufficient_or_context_specific +LHFPL6 0.619176050592422 0.0614721359877474 0.4217172266138 0.606268207437928 0.0678638307965278 0.43786261079484 0.474938849036934 0.345797575327784 0.214733466734262 3.0 True False False False False False False 0 insufficient_or_context_specific +PLIN5 -1.22601208108798 0.0615644215876355 0.421963941037269 -1.19811572750956 0.0684718568366463 0.438244764077482 -0.626417399170984 0.125525121727138 0.661896583757963 0.0710111660469304 0.0354791845869792 0.934797356101613 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NMT2 -0.46223982425862 0.06166427190064 0.421963941037269 -0.437596131946061 0.0792498542616556 0.459078388240937 -0.229709254327062 0.435827243641088 -0.434478243438041 0.0882809629413212 -0.664187497765103 0.0255287889718218 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF3J -0.485819580020317 0.0617208715533779 0.421963941037269 -0.440610393058252 0.0948097720710371 0.474786889361867 0.358301505155781 1.0 False False False False False False False 0 insufficient_or_context_specific +EME2 -0.903442513223743 0.0617626522340894 0.421963941037269 -0.842142476183918 0.0862204038675487 0.467677448123587 0.855499415610435 1.0 -0.365342134987642 0.386723732486177 -0.507460487249101 0.165491659434131 -0.872802622236744 0.0386673147865856 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RMDN3 -0.39256649412647 0.0619070455915296 0.421963941037269 -0.313366982188968 0.141124741595664 0.526686115859676 0.4974354352102021 1.0 -0.386568737972313 0.204005392712339 0.553484585718315 0.0463744401057773 0.166915847746002 0.56131520805434 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF2B4 -0.565978700327922 0.0619813590204028 0.421963941037269 -0.795448700524634 0.0047818340105558 0.261521011602645 0.103917577751409 1.0 -0.0549482638184565 0.893706359585748 0.10872034009675 0.709152901316051 0.0537720762782935 0.876442792669679 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CS -0.556706082329492 0.0622026711971337 0.422609911518235 -0.452124208286175 0.135144891991204 0.521860900181769 0.475416244637729 1.0 False False False False False False False 0 insufficient_or_context_specific +QARS -0.656367188195435 0.0622692057050269 0.422789886709758 -0.648505944737909 0.0662007796341652 0.436071024157137 0.439857576734334 1.0 -0.0333021596205891 0.923829014015082 -0.225287298325953 0.328607101199456 -0.258589457946542 0.298905580034888 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GRTP1 -0.667245796263851 0.0626029528004059 0.423458235676911 -0.890676010650768 0.0087789326845896 0.291509786412688 -1.09070932840819 0.0421197585484876 0.838981680466438 0.0723127075576608 -0.251727647941755 0.602395728708601 reversed False False False False False False False 0 insufficient_or_context_specific +CFHR3 -0.891756358471093 0.0626343474149045 0.423458235676911 -0.314133444654362 0.510454592133247 0.796519013040946 False False False False False False False 0 insufficient_or_context_specific +OSBP -0.329353728998785 0.0626885538087479 0.423458235676911 -0.185474759758087 0.308902934557898 0.66261625011424 -0.196463245004506 0.517827867504849 -0.033061891444044 0.909444232047331 -0.22952513644855 0.383001194996849 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NPAS3 0.563280032762636 0.0627101893299661 0.423458235676911 0.309265595681607 0.313123860182787 0.665719233952852 0.3503320547155711 0.265425827920169 0.0748303888616555 3.0 True False False False False False False 0 insufficient_or_context_specific +FAM208B 0.289577288180244 0.0627286115361517 0.423458235676911 0.329603046967073 0.0323083405674591 0.375031405408838 0.156045531648342 0.0889971803170766 2.0 True False False False False False False 0 insufficient_or_context_specific +TNRC18 -0.321969557426874 0.0628990797972284 0.4237357774587 -0.401592931701275 0.0172657260966786 0.326204572615871 0.302980027422032 0.539340185058975 2.0 -0.0108193044971426 0.973992272126759 -0.304329679113338 0.191868445706223 -0.315148983610481 0.196571525387654 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SERPINF1 0.792332357088977 0.0629167610975766 0.4237357774587 0.851650453350106 0.0457081969104139 0.396538326195686 1.32895663163106 0.7510741357147209 0.183285164188053 3.0 -1.27847150570803 0.0049927811393144 1.83582305662847 0.0009757960507563 0.557351550920446 0.121345919388659 reversed True False False False False False False 0 cross_species_direction_conflict +MAP4K2 -0.530013861672744 0.0629282439465741 0.4237357774587 -0.416119108165947 0.152015940917195 0.534638342506245 0.6965507940135001 0.336101855508835 2.0 -0.332502736073528 0.381403885138834 -0.707083757867714 0.044832639827498 -1.03958649394124 0.0131767983807574 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TOMM70 -0.377391323982947 0.0629302613236637 0.4237357774587 -0.145814649701622 0.463351834733933 0.769320698854699 0.280389301834288 1.0 False False False False False False False 0 insufficient_or_context_specific +PRKAA1 0.32455021623594 0.0629720879472867 0.423747166696911 0.0913726223470671 0.609611525321526 0.848013066172034 -0.0307247569376882 0.935525302777025 0.105850673205928 0.679697654567177 0.0751259162682399 0.800798170345124 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAP2K3 -0.857855000778725 0.063085807782044 0.42420050260431 -0.758342618281296 0.106068605662529 0.483261130274234 0.529435744177787 0.3603874794314461 2.0 0.14508552418852 0.610564993474888 -0.0520190436554312 0.835794353558118 0.0930664805330889 0.720853108766921 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WASHC2A -0.487679448049687 0.0631722784535806 0.42420050260431 -0.289704433164139 0.286484346929995 0.64687121300967 False False False False False False False 0 insufficient_or_context_specific +LAMTOR3 0.540077137363339 0.0631796568593767 0.42420050260431 0.560950064263895 0.0535920530071302 0.417274996791505 0.00817960141009747 1.0 -0.0018036078615534 0.996617940730295 -0.0232306637224142 0.937182186482171 -0.0250342715839677 0.937535796537767 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DOK6 0.641262395572404 0.0632186079009266 0.42420050260431 0.740539299441214 0.0291181195586526 0.369506137380113 0.288322340515462 0.4071381148119099 0.218118155606649 3.0 True False False False False False False 0 insufficient_or_context_specific +BAALC-AS1 0.765645767183542 0.063291120419843 0.42420050260431 1.05229403178467 0.0112686983372512 0.302570357129259 0.0537941511815455 1.0 True False False False False False False 0 insufficient_or_context_specific +SIMC1 0.566878515584199 0.0633354484177688 0.42420050260431 0.362872809789506 0.232178885670448 0.602195334480623 0.132927359052557 0.192265707525561 2.0 -0.682847337366868 0.135763868876701 -0.173126421662317 0.683298112767738 -0.855973759029185 0.0568889541870215 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NDRG1 0.836997477711005 0.0633608820427162 0.42420050260431 0.531528275377702 0.240201529068435 0.607145737109058 0.0920215012746466 0.029642247019816 2.0 -1.00698778770615 0.0049927811393144 0.854474576395368 0.0087586569796875 -0.152513211310779 0.600840010918442 reversed True False False False False False False 0 cross_species_direction_conflict +PDE10A -0.609558387343998 0.0636085408035049 0.425322424281434 -0.363148979292295 0.288149013467847 0.648258530618693 0.129988538413233 0.826366297528556 -0.0114944747350921 0.980396812482588 0.118494063678141 0.812201448650283 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIPE-AS1 0.672827293567395 0.0636531412575154 0.425322424281434 0.449156357349546 0.202092354906967 0.57668584531318 1.13814680198017 1.0 True False False False False False False 0 insufficient_or_context_specific +PLCXD3 0.87574720727428 0.0637149904896773 0.425322424281434 0.798586326299606 0.0911556625076559 0.472234212482528 0.5563395626305949 0.695922888345847 0.40219883652136 3.0 -0.385771426555309 0.763833046449035 1.68833860431643 0.0337170069446658 1.30256717776113 0.12461319926319 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM162A 0.561332449373714 0.0637379706741766 0.425322424281434 0.627497898283745 0.0384667255597748 0.379484931484566 0.0718682440973538 1.0 -0.259876496361665 0.357458084101065 0.573145619617461 0.0293707171644936 0.313269123255795 0.215247869862995 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC245060.5 -0.754800995014405 0.0637701645801771 0.425322424281434 -0.70349696997338 0.0872025721895748 0.468303538747472 False False False False False False False 0 insufficient_or_context_specific +BMP1 -0.597698218829555 0.0639598701329029 0.426318376807568 -0.636995695169624 0.0464511189325409 0.398741839274603 1.72287191716505 1.0 0.117093394960266 0.700886222232754 -0.550788260314168 0.03396584460549 -0.433694865353902 0.0922252254658191 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HMG20B -0.525603043606764 0.0640735590293075 0.426537601659161 -0.64816270599459 0.0206906936909729 0.333389311130767 0.402982985654395 1.0 0.231193803795651 0.488290613960207 -0.551159087776341 0.0577080394056011 -0.31996528398069 0.275509036351509 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTF2F1 -0.544149433436787 0.0643036953236784 0.427141335976443 -0.657604708919407 0.0195224156677988 0.330467462546779 0.280721427328372 0.305613434681187 -0.293736796254412 0.200708834463645 -0.013015368926041 0.965989551879165 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FENDRR -0.954415567921536 0.0643517421401668 0.427141335976443 -1.0651043037401 0.0372404696342193 0.379484931484566 False False False False False False False 0 insufficient_or_context_specific +C12ORF45 -0.554027203186578 0.0643735774537931 0.427141335976443 -0.540939210087103 0.0714415600306006 0.44579195673941 0.837132834582641 1.0 False False False False False False False 0 insufficient_or_context_specific +LINC02062 0.592545730146511 0.0643816140744834 0.427141335976443 0.320866476287075 0.320283098087607 0.672472248121257 0.0352386675171289 1.0 True False False False False False False 0 insufficient_or_context_specific +FURIN -0.615876499943831 0.0644069906113371 0.427141335976443 -0.584618178858565 0.0812179990698929 0.461068439742811 0.7085592700078329 1.0 -0.565671086853147 0.158992152863068 0.454380142698133 0.200570996484521 -0.111290944155014 0.785938290848698 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP1R2 0.44058455296578 0.0645012748493273 0.427196202818368 0.213372899036271 0.343729683282347 0.690520414025153 True False False False False False False 0 insufficient_or_context_specific +PDSS1 -0.458427282109863 0.0645628019226829 0.427196202818368 -0.206520793520555 0.399540358307849 0.729679668746226 0.360761711647686 0.388466324905447 -0.601142696012706 0.0871403221387596 -0.24038098436502 0.550722863983867 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DTWD2 -0.523122768118506 0.0646510992751462 0.427196202818368 -0.537525956018009 0.057193207553938 0.424455207563489 -0.203998848155533 0.797710546166591 0.006229123000744 0.992734420924669 -0.197769725154789 0.769970346766072 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP1G2 -0.885576527306995 0.0646838700947796 0.427196202818368 -0.606427890080346 0.22596523884926 0.598493814456385 -0.467514882811965 0.183901878864476 0.020158942123508 0.954211945194373 -0.447355940688457 0.170567896721963 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POT1 0.469027315986148 0.0646976383888413 0.427196202818368 0.445729744863448 0.0795911138859151 0.459160525051927 1.52412829025043 0.0389915568092543 2.0 True False False False False False False 0 insufficient_or_context_specific +AKR1D1 -1.82603756809536 0.0647077818445832 0.427196202818368 -2.14753017742905 0.0265415303234036 0.354715793866449 -0.30792790347441 0.421809662983609 0.836106814214094 0.0200583068883145 0.528178910739684 0.121137352315754 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR31 0.832855984460928 0.0647630581305042 0.427196202818368 1.09008516514365 0.015623893815761 0.320853404849916 0.863483529331035 0.0238392762898876 2.0 True False False False False False False 0 insufficient_or_context_specific +AC010615.4 0.916150416107245 0.06487603704735 0.427566291601698 0.828461579324043 0.0976183947930858 0.478125555523304 0.0592929159648988 1.0 True False False False False False False 0 insufficient_or_context_specific +TRPV1 -0.628362365330088 0.0649592563539777 0.427567820691514 -0.670561857557116 0.0469079176899747 0.399450754777127 False False False False False False False 0 insufficient_or_context_specific +AC099669.1 0.50725169064228 0.0649682529872059 0.427567820691514 0.449919406257901 0.101047620168202 0.478335084675213 0.043246418552127 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF850 0.536268674295633 0.0653022704295779 0.429039075019342 0.0687267143560139 0.816512526446123 0.936230700610385 0.328266408254953 1.0 True False False False False False False 0 insufficient_or_context_specific +HEATR5A -0.26842087943207 0.0654479247915029 0.429497600467991 -0.159238179391337 0.283125388854412 0.644071250922027 0.208064916749228 0.506441698050267 -0.690380046598482 0.0180336972888686 -0.482315129849254 0.0902475606147924 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTBP1-AS 0.77730510875353 0.0654545481880493 0.429497600467991 0.180004680978521 0.674411764699004 0.878130100384814 0.239639546149472 0.298423516678141 2.0 True False False False False False False 0 insufficient_or_context_specific +DKC1 -0.621680523535581 0.0655622939127926 0.429497600467991 -0.574788207190063 0.0920837511746827 0.472460751419842 0.31029607827594 0.453152301224199 0.0884862412396619 0.791939505073795 0.398782319515602 0.270369010156607 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF383 0.561147073568408 0.0656942451380029 0.430006100537529 0.823692271752247 0.006552505086608 0.277955891686679 0.402643316453291 0.0487348309726496 2.0 True False False False False False False 0 insufficient_or_context_specific +SIPA1L3 -0.326975584933232 0.065933009818105 0.431173731505513 -0.345135240104643 0.051888156726104 0.411906134371584 0.49369590977193 1.0 -0.351156279297054 0.388988153306413 0.103900013839 0.774791882855681 -0.247256265458054 0.506271020533751 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR72 -0.851465166269935 0.0659912541776592 0.431173731505513 -1.03313156973216 0.0245587167224631 0.349408136686844 False False False False False False False 0 insufficient_or_context_specific +MMP24OS 0.309560368336903 0.0660129206289702 0.431173731505513 0.246165815031311 0.134193258765822 0.520900171021663 True False False False False False False 0 insufficient_or_context_specific +PDE4B -0.522133457211372 0.0660359844520188 0.431173731505513 -0.398460206594908 0.164503236830277 0.544850245278 0.544505026669885 1.0 -1.05861945361084 0.0100368683022182 0.633235373028121 0.063332838620738 -0.425384080582718 0.207584036685784 reversed False False False False False False False 0 insufficient_or_context_specific +RNF123 -0.65052920261935 0.0661261945952633 0.431235896951262 -0.547828384604307 0.126247409172737 0.508384607335028 -0.447344228341396 0.098439978866149 -0.0246075137547117 0.93029383911543 -0.471951742096108 0.0698953625930011 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VARS2 -0.675395286947521 0.0662415829059881 0.43171520513668 -0.712691122246462 0.0521279962163945 0.413188726766286 0.149623034849897 0.668288779413754 -0.780924091311426 0.0135226587506486 -0.631301056461529 0.0462746691067434 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC090825.1 0.490571387209007 0.0663176988400578 0.431803382833016 0.340331484819188 0.205569324360233 0.578666837313374 True False False False False False False 0 insufficient_or_context_specific +PQLC2 -0.72502165750727 0.0663605896526428 0.431803382833016 -0.379740555747537 0.370150934457995 0.709652000364538 -0.126500095855764 0.756740533625439 -0.387223156239396 0.199373357705709 -0.51372325209516 0.122466799426199 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00894 0.503807644512919 0.0664476332632205 0.431803382833016 0.521045913486509 0.0573791580917306 0.424455207563489 0.289132323923651 0.164596304619399 0.174961029220602 3.0 True False False False False False False 0 insufficient_or_context_specific +PRKD2 -0.42641963130679 0.0664584285826004 0.431803382833016 -0.558603036710071 0.0139680533811213 0.314756631908661 0.0254686938258354 0.950285004327358 -0.151434002163094 0.587269767734075 -0.125965308337259 0.688527487255685 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBC 0.80459972011682 0.0666028757857356 0.432431468698827 0.816248689340878 0.063109465511723 0.432999502601999 0.48700836512583 1.0 -0.437184692051032 0.195969442554011 0.650665898082304 0.042607068973426 0.213481206031272 0.502723274376053 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MASP2 -0.775263069146109 0.0667128648120516 0.432431468698827 -0.87512476400496 0.0372083242294701 0.379484931484566 -0.996132263478934 0.0108059577780008 0.983371138911403 0.0092768518657045 -0.012761124567531 0.974248396582174 reversed False False False False False False False 0 insufficient_or_context_specific +LMCD1-AS1 0.509014242576339 0.0667343229283401 0.432431468698827 0.463044998214419 0.0959919666847179 0.47569521889622 0.610353312876447 0.840913290236073 0.102234935813226 3.0 True False False False False False False 0 insufficient_or_context_specific +TNXB -0.445853237751793 0.0668161071361084 0.432431468698827 -0.343307459011165 0.159245682620543 0.543060696740211 0.8894906242430509 1.0 -0.547086376568403 0.098439978866149 0.341329298464947 0.240823712817243 -0.205757078103455 0.508507845005585 reversed False False False False False False False 0 insufficient_or_context_specific +HLCS 0.258050504355326 0.0668562140344844 0.432431468698827 0.253698082376428 0.0707710421834403 0.443801226075734 -0.0528543431941261 0.90535355614614 -0.756092976079701 0.0241932629254424 -0.808947319273827 0.0284376587046979 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KLHL7 0.382593147692436 0.0669492733196333 0.432431468698827 0.419333820693753 0.0447980937819144 0.393650849907072 -0.358108224922013 0.39085953577373 0.16023072851343 0.655307989554567 -0.197877496408583 0.610519401148144 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC20A2 -0.291844079891114 0.0669857406306644 0.432431468698827 -0.271221494590539 0.0864907998974838 0.467677448123587 0.0559791328992811 1.0 0.520945814892488 0.268743912777657 0.0625082747436577 0.890844694725049 0.583454089636146 0.177043293713037 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDC25B -0.654065107001729 0.0670062881704632 0.432431468698827 -0.530750831190007 0.147375854952877 0.532796338690088 1.34416432812607 0.004038132209842 -0.701954523382812 0.0354818712239347 0.642209804743253 0.103325638117996 reversed False False False False False False False 0 insufficient_or_context_specific +RPS2 0.648689725197035 0.0670152064805836 0.432431468698827 0.7039274238478 0.0466024731338019 0.398865057227663 0.0187606191326962 1.0 True False False False False False False 0 insufficient_or_context_specific +USP8 -0.216624808824379 0.0671042515434103 0.432431468698827 -0.189470363850715 0.1141594574117 0.4924007041452 0.340210352522133 1.0 -0.180330643692294 0.481310286117884 -0.0910216560280359 0.683972751291304 -0.27135229972033 0.22539790175919 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYBC1 -0.65039970756593 0.0671115011154681 0.432431468698827 -0.762198840388392 0.02853640117881 0.3674235654218 0.7413874688882192 1.0 0.364530322517171 0.325477854623275 -0.582354343166166 0.0736734941147535 -0.217824020648995 0.539821382220508 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CD99 -0.468367566707154 0.0671534305697054 0.432431468698827 -0.781883044747612 0.0008226575237429 0.177355916186346 0.482345343718413 1.0 False False False False False False False 0 insufficient_or_context_specific +GLO1 0.579418507498999 0.0671706391992873 0.432431468698827 0.161397631433146 0.613458366798972 0.850400399282578 -0.949950541970102 0.0641495577533093 1.47802035077908 0.0074475470008089 0.528069808808981 0.251615726365561 reversed True False False False False False False 0 cross_species_direction_conflict +PPP1R14A 0.616894849097073 0.0673250249586567 0.432719087707076 0.682312199902 0.0423219395384483 0.3908928278867 1.33923862692476 1.36406935828646 0.04529602617524901 3.0 -0.129941277190015 0.743736853249866 -0.0688569702337798 0.837038370591978 -0.198798247423795 0.544931979203416 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TEAD2 -0.607586200859567 0.0673385240816586 0.432719087707076 -0.494360818020772 0.142143387955905 0.527875444966036 1.11775845001581 1.0 1.64842441647055 0.0005141837336183 -1.99980641265835 0.0002529195248089 -0.351381996187801 0.340892056403477 reversed False False False False False False False 0 insufficient_or_context_specific +IKZF4 -0.417380321667758 0.067379255558859 0.432719087707076 -0.509453662228631 0.0261570495228962 0.354014155751332 -1.20849726387422 0.0729089194565824 0.882665779182434 0.118295058377668 -0.325831484691786 0.578164783557162 reversed False False False False False False False 0 insufficient_or_context_specific +GFM2 0.36749760977989 0.0674286680359052 0.432773177582423 0.322776318117812 0.111126482230673 0.488819418659101 -0.0748764312877769 0.820391810200688 0.0532264571501224 0.836125838687597 -0.0216499741376544 0.940983872319279 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LENG8 -0.439041014062321 0.067481133586849 0.432846785182231 -0.39329980150489 0.104032677718766 0.480263154193818 -0.182434343772718 0.597847856752033 -0.217750622852523 0.439183670907803 -0.400184966625241 0.173118735898919 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HNRNPH1 -0.324739385229907 0.0677441036163203 0.43335223588253 -0.368563886226233 0.0356495883870032 0.37720666979567 0.3399262812414329 1.0 0.265503220484704 0.399203551674546 -0.117671391430897 0.672240404962407 0.147831829053807 0.618330297773438 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC22A3 -1.02235398234093 0.0678980613223453 0.433623410529439 -1.02957994889266 0.0660035681046022 0.436071024157137 False False False False False False False 0 insufficient_or_context_specific +TENT5A 0.498724001785238 0.0680768563364811 0.434293322779799 0.484505059819986 0.0771633182849943 0.455668688469891 0.283084511514841 0.598652997665252 0.110664371747033 3.0 -0.762389437928194 0.0509801141691565 0.8757247417923 0.0178272488462107 0.113335303864106 0.76290934759584 reversed True False False False False False False 0 cross_species_direction_conflict +DCDC1 -1.00092861338699 0.0681991376224577 0.43446260179429 -0.734089347956626 0.196134931522353 0.571726285757319 False False False False False False False 0 insufficient_or_context_specific +AZIN1 0.43489737398624 0.0684350385808412 0.43446260179429 0.669887277004846 0.0025513311729457 0.224500148429329 0.0701314516145469 1.0 -0.0029296922694415 0.995167110711914 -0.123886009269698 0.69375032129719 -0.126815701539139 0.713575680578491 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CPT1A -0.248100537654596 0.0684930351194491 0.43446260179429 -0.160173497857113 0.241672978232238 0.608725035015447 -0.287330294968526 0.548278111228744 0.706914713297723 0.0793610923394918 0.419584418329198 0.303345305036696 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A18 -1.00802504503688 0.0685252908231866 0.43446260179429 -1.20165763702429 0.0259438440931376 0.353316498154592 0.221894581450662 1.0 False False False False False False False 0 insufficient_or_context_specific +ZSCAN30 0.412997804973935 0.0688358174075368 0.43446260179429 0.287638151213784 0.213373460987945 0.58619600202041 True False False False False False False 0 insufficient_or_context_specific +ESRP2 -1.34972060022418 0.0689931963448141 0.43446260179429 -1.50367251070654 0.0390796677726696 0.379484931484566 0.351967985478976 1.0 -0.7890038877542 0.0472241856003908 0.521486549096629 0.123265875777624 -0.267517338657571 0.447494254014935 reversed False False False False False False False 0 insufficient_or_context_specific +NUP50-DT 0.553278480532458 0.0690912915643471 0.43446260179429 0.357339643465388 0.259561454208399 0.622885940784012 True False False False False False False 0 insufficient_or_context_specific +EPG5 0.385710637610095 0.0691938121322251 0.43446260179429 0.416545627325257 0.0479099563512519 0.401952804329389 -0.124296300162823 0.662459607246125 0.329034108905887 0.130066382578426 0.204737808743065 0.379372213818559 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MMP24 0.759769382841383 0.0692465936393089 0.43446260179429 0.779274231741184 0.0631268053919127 0.432999502601999 0.855776094419802 0.0238941258057691 2.0 True False False False False False False 0 insufficient_or_context_specific +AKAP8L -0.372362283007613 0.0692519254469803 0.43446260179429 -0.363924532711363 0.0759800250561638 0.454582718735293 0.5776306616410849 1.0 -0.527355985601925 0.175144956637759 -0.520362198671612 0.136860388806007 -1.04771818427354 0.0150406255881101 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCNX3 -0.628990964239836 0.0692564898229933 0.43446260179429 -0.663451650123093 0.0550437768046867 0.420515336833489 -0.198186853037698 0.473897760585375 -0.670832100498809 0.0134136082408191 -0.869018953536507 0.0063047598527459 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PGAP2 -0.546573090322497 0.0692858249922164 0.43446260179429 -0.544803926936934 0.0703396467862544 0.443089546602487 0.460348859966309 1.0 0.206336828370519 0.58067932575437 -0.262804540416777 0.362568393658862 -0.0564677120462581 0.880479397049426 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIF26B -0.841981202971956 0.0692968508405832 0.43446260179429 -0.584278625613163 0.20721389751458 0.580154953582323 0.9404022618202071 1.0 0.561988646866309 0.731556142006226 -3.49124282937383 0.0430071571242766 -2.92925418250752 0.135880271542889 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COMT -0.297295030787147 0.0693520990528527 0.43446260179429 -0.351928224439851 0.0269166501672066 0.356222495883986 -0.894357333551551 0.117355043454552 1.51773105525097 0.0115693129425266 0.623373721699419 0.231937134046773 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HECTD3 -0.755264761303761 0.069522748961677 0.43446260179429 -0.481674375361434 0.281522584297718 0.64315368591277 0.8242235886119279 1.0 -0.481825663034086 0.0599558198624611 -0.176381386783556 0.429975782046547 -0.658207049817643 0.0164616777115953 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NPIPB15 -1.15665392515021 0.069536439572471 0.43446260179429 -1.20518435181363 0.0573920468676967 0.424455207563489 False False False False False False False 0 insufficient_or_context_specific +AP1S3 -0.435740438364985 0.0695436646869624 0.43446260179429 -0.0524834145267816 0.835635348936905 0.94678550423503 False False False False False False False 0 insufficient_or_context_specific +PRRT3-AS1 0.73225637852256 0.069549861753859 0.43446260179429 0.688019631239566 0.0905250922456802 0.472234212482528 True False False False False False False 0 insufficient_or_context_specific +WDR13 -0.601770897995193 0.0695636018738254 0.43446260179429 -0.579458955160261 0.0822732016822202 0.462431570888118 0.3135654862790689 0.516146273675662 2.0 -0.027915393867156 0.941557927991871 -0.585577518590534 0.0373738919866842 -0.61349291245769 0.0390584644465845 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C3ORF58 0.717540827813848 0.0695987569409473 0.43446260179429 0.389471078225589 0.307894191708304 0.662243470533128 0.0386181263974139 1.0 True False False False False False False 0 insufficient_or_context_specific +RAB28 0.259602397530396 0.0696620278345882 0.43446260179429 0.326673589334543 0.0196878228776211 0.330467462546779 1.18161672386471 1.0 -0.158533256257431 0.668392557309104 -0.0267107619296889 0.936077834746477 -0.18524401818712 0.557715066099437 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC098850.3 0.844369234815172 0.0696823760585782 0.43446260179429 0.981400045128502 0.0323485280341576 0.375031405408838 0.152577348104654 0.192996492705749 2.0 True False False False False False False 0 insufficient_or_context_specific +GOLGA3 -0.385767528850727 0.0697880796724266 0.43446260179429 -0.326440801736285 0.129563343559811 0.514452719557911 0.105555873355278 0.686063516000436 -0.41962007623761 0.0503716058143642 -0.314064202882332 0.149084972466462 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP2D6 -0.825750118706493 0.0698740846396981 0.43446260179429 0.0228695144294378 0.955973002314778 0.987410276805219 False False False False False False False 0 insufficient_or_context_specific +PPP1R16A -0.587731129322984 0.0699020501591711 0.43446260179429 -0.527515445160197 0.10763368552651 0.483778821536355 0.580650509583416 1.0 -0.340841040471981 0.116744787556018 -0.379149424154649 0.0598570493122512 -0.719990464626631 0.0061222386305539 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIPC -0.784106453181347 0.0699095161637876 0.43446260179429 -0.64872591896746 0.137244054738039 0.523810858054217 -1.51150770096932 0.0048247305212234 1.91873202130121 0.001541021056078 0.407224320331888 0.318426315942166 reversed False False False False False False False 0 insufficient_or_context_specific +DDX58 0.395331480951108 0.0699551452027176 0.43446260179429 0.499021905595935 0.0198228898485875 0.332176266033792 -0.0604148368845199 0.870335910618566 -0.236415810850883 0.357140735926483 -0.296830647735403 0.279893024623986 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL138963.1 -0.523314839488208 0.0700715760738271 0.434596933193263 -0.681007071486456 0.0139063061737852 0.314756631908661 False False False False False False False 0 insufficient_or_context_specific +MIPOL1 0.385587188696275 0.0701002630449069 0.434596933193263 0.380401792004676 0.0741101757372125 0.452862231765951 0.150990146625826 1.0 -0.333044489056284 0.60263093881044 -0.433540012789358 0.397192853140087 -0.766584501845642 0.173759937273694 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPL8 0.591955953889564 0.0701599459143534 0.434711683664169 0.692026232149943 0.0362139198205485 0.377439847448521 0.606078540771538 1.0 True False False False False False False 0 insufficient_or_context_specific +TMEM120B -0.530186634085951 0.0702452595218445 0.434963088892314 -0.463362310844097 0.123328977822884 0.504888463689032 -0.0157188317097352 0.981117342485003 -0.407574078733319 0.340989670504088 -0.423292910443054 0.387633225509222 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ETS1 -0.620492729625791 0.0703225000087496 0.434963088892314 0.127310442864153 0.738898098238188 0.907558041400239 0.430203195815116 1.01916474716754 2.0 -0.134775652258894 0.784039873542692 0.168181264283837 0.661208120838912 0.0334056120249428 0.940983872319279 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAJC5 -0.414907428402612 0.0703241137279011 0.434963088892314 -0.47386022942336 0.035138298656508 0.37720666979567 0.0023472654611112 0.993804153998224 -0.0316322615143266 0.886848356776468 -0.0292849960532154 0.903117914154853 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1ORF159 -0.360784470268281 0.0704733647204705 0.435631021498084 -0.274332042079467 0.187142105444185 0.56929178900529 False False False False False False False 0 insufficient_or_context_specific +FLOT2 -0.59724239686225 0.0705963728941962 0.435915718192407 -0.464329974238934 0.162886347703642 0.544298760692042 -0.335034208046838 0.123959360319386 0.192152102378416 0.311896044417269 -0.142882105668422 0.483101639829387 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHTOP -0.334346340852372 0.0706019964111589 0.435915718192407 -0.391283845847465 0.0307234647392063 0.375031405408838 0.145781473404528 1.0 0.0731808891310327 0.782321508001668 -0.1214412216642 0.542443434525658 -0.0482603325331675 0.837706033154377 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCTD9 0.48199020221456 0.0706898742128803 0.436203209783513 0.354995511505559 0.188816091919726 0.569351952070621 -0.130272329487986 0.807811216484422 -0.648866239884347 0.101139942895551 -0.779138569372334 0.0756132877287279 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RAB11FIP3 -0.393549663166063 0.0707998195483442 0.436269469784648 -0.388811776577876 0.0742148370879687 0.452862231765951 0.437628790200901 0.0837263720715106 2.0 -0.0748702172526342 0.843911857110284 -0.621820123312637 0.0339503617718795 -0.696690340565271 0.0284055464146005 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC17A4 -0.956237168596287 0.0708342689528385 0.436269469784648 -0.995140828938161 0.0590566633032087 0.428240742414856 -1.03344787675954 0.203013246598892 1.42613841810492 0.045423387240765 0.392690541345381 0.582298358076469 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC38A10 -0.318504653431095 0.0708379110759218 0.436269469784648 -0.277764054597549 0.115042805714081 0.49294721701675 0.197174775521352 0.541887269608551 -0.335967256456505 0.203451303522686 -0.138792480935153 0.638072887271695 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NBR1 0.488551156325504 0.0708658970146496 0.436269469784648 0.238077580764561 0.370603059561511 0.709933692593666 0.733115469394653 0.439005017574289 0.0640105200946772 3.0 -0.498410443301225 0.0833932103253286 0.435239658180881 0.0916442376611025 -0.0631707851203446 0.831832018608125 partial_or_other True False False False False False False 0 cross_species_direction_conflict +POLG -0.447150434197048 0.0709967268968931 0.436820187982166 -0.109049187969874 0.677920788948823 0.879886294337383 0.135129235301228 1.0 0.0722350279462122 0.807918018642436 -0.18836166047044 0.373829335640983 -0.116126632524228 0.628496246472104 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC011287.1 -1.38669961639165 0.0711089764038719 0.437034671944914 -1.4383431955024 0.0607674390477462 0.429268745755419 False False False False False False False 0 insufficient_or_context_specific +ADD1 -0.374131764829334 0.0711143745407618 0.437034671944914 -0.354527907449894 0.0887194919389311 0.469932751718496 0.624270204667928 1.0 0.0513713779670936 0.88240320279816 -0.0733485124750666 0.774686451610552 -0.0219771345079729 0.940983872319279 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NORAD 0.525218114050917 0.0713640947203734 0.438059367475409 0.650535321349382 0.0222765394009773 0.346028040476539 0.648995400839986 0.0499702028076968 2.0 True False False False False False False 0 insufficient_or_context_specific +SIGLEC1 -1.2869692370682 0.071440528355852 0.438273735259201 -0.461948183463472 0.561025894349218 0.822885417488071 1.72315414943552 0.0672462335464933 -0.909221499203323 0.173929023263247 0.813932650232196 0.381383968763807 reversed False False False False False False False 0 insufficient_or_context_specific +GGT5 -0.616040159829923 0.0716221594740666 0.439132845370032 -0.444097119795259 0.209465680293555 0.581735440450297 0.649711290242989 1.0 -0.0336598084292267 0.957989552701686 0.0593928654902538 0.907794803807253 0.025733057061027 0.963041361867895 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GREM1 2.8981131794832 0.0716677465451338 0.439157323287012 2.89061379967607 0.0769621866639098 0.455668688469891 0.729105488573803 1.0 True False False False False False False 0 insufficient_or_context_specific +STX7 0.464782242215956 0.0717522954263312 0.439420379994898 0.446634350413184 0.0842276124969484 0.464779732481256 0.0588510553581497 1.0 -0.186606936960781 0.571157588860904 -0.0070732195185143 0.982326201083543 -0.193680156479295 0.498948051728217 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LSM12 -0.450989094827142 0.0718052392068063 0.439489690171282 -0.446055134209909 0.075274482478948 0.453382804479479 0.700959274281688 1.0 0.521200563150484 0.122267768146589 -0.0949637108250098 0.752144743110699 0.426236852325475 0.172621494633672 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKLE2 -0.303355849974523 0.0722401100928823 0.440364366259036 -0.265853101942122 0.120383177712749 0.501524675000431 0.0455400342567699 0.895696465239926 -0.0685414782639929 0.786241638006412 -0.023001444007223 0.938323454407847 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TROVE2 0.445679081505708 0.0723312058228897 0.440665245861552 0.541706296962687 0.025724682937234 0.351427309358494 0.0695844770806271 1.0 True False False False False False False 0 insufficient_or_context_specific +UBE2Q1 -0.62500337251045 0.0725798181510797 0.440815469224225 -0.370513717312533 0.309583630683774 0.662858728430055 0.338794223978175 0.560051145532585 2.0 0.371593969046309 0.212509447857799 -0.110454482827714 0.677585067137296 0.261139486218594 0.343401171080253 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SELENOW 0.361362195937662 0.0726273949575295 0.440815469224225 0.287692677335721 0.153684441446515 0.53657418412444 -0.208485568738 0.440285529345014 0.142260281852747 0.53972382027908 -0.066225286885253 0.80325409938213 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM150C -0.941872171268653 0.0726730500746034 0.440815469224225 -0.977281046798709 0.0620984787592558 0.431813959784778 False False False False False False False 0 insufficient_or_context_specific +ARHGAP26 0.672338423641867 0.0726978376602573 0.440815469224225 0.217012449068819 0.574310740817415 0.829149842957783 0.291970353716574 0.0722772774426916 2.0 -0.0511017908047551 0.911240264788933 -0.49268474744717 0.114173315998268 -0.543786538251925 0.11004020042208 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RILPL2 0.512638852878301 0.0727231158999117 0.440815469224225 0.358459656245987 0.208571724751951 0.580875829578236 -0.130802985400974 0.726514481255491 -0.282864965836837 0.317549453233184 -0.41366795123781 0.176380589260988 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CNN1 1.45573301553901 0.0729029924926672 0.440815469224225 0.822139362108805 0.305849811575724 0.661696690217148 1.20566046795814 0.0990692849213768 2.0 True False False False False False False 0 insufficient_or_context_specific +DPY19L4 -0.381891494217371 0.0729352613833521 0.440815469224225 -0.452179583289438 0.032378740703736 0.375031405408838 0.0411369318274778 0.926507226037505 -0.200916702206801 0.492849499987734 -0.159779770379323 0.635434805045057 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WFDC10B 1.42397950675335 0.0729520684760956 0.440815469224225 0.293881782135609 0.679188123361298 0.880617488204419 True False False False False False False 0 insufficient_or_context_specific +CREBRF 0.482155639998302 0.0731221195712756 0.441408426777317 0.165733999612206 0.551355824973025 0.817770107102835 0.31762106727792 1.0 -0.330881850124676 0.372401606191967 0.364547659447822 0.238178461086442 0.0336658093231466 0.930062422411116 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SARDH -0.528520973793111 0.0731809429101621 0.441511082997423 -0.478258060736578 0.110216709017107 0.487094187443539 0.878355156600722 0.336790609388882 2.0 -0.596274490266499 0.180814120271385 0.927903764927421 0.0314789452477098 0.331629274660923 0.419891485874905 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM72-AS1 0.614144257516696 0.0732991239375701 0.441762674067446 0.243483614078075 0.482366410486366 0.780666906162311 0.61242809000592 1.0 True False False False False False False 0 insufficient_or_context_specific +PMS1 0.394603175021118 0.0734464262863874 0.442354460200615 0.41916870255197 0.0545975983286472 0.419535257026097 -0.255901795216149 0.601682485981271 -0.0600335565249887 0.8916617443103 -0.315935351741137 0.452237645846634 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SKI -0.462133760298271 0.0734910420032555 0.442370821818912 -0.411331883375993 0.116780050107192 0.495962899851862 0.18281294946938 0.5282617341245099 2.0 -0.0064749217561259 0.986196725463102 -0.0246011214711621 0.93137271333844 -0.031076043227288 0.918258746367039 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FNDC1 1.60017648601029 0.0735702963054686 0.442588232064817 1.86406841336518 0.0549455304135223 0.420068725637921 -1.81808023172593 0.0604482916249434 1.27253401609431 0.126243873965407 -0.545546215631617 0.491648537303397 reversed True False False False False False False 0 cross_species_direction_conflict +FCHO2 0.37481250284977 0.0737066313207143 0.4429109923074 0.200997831350693 0.342354006047084 0.689130402583821 -0.0692271861884265 0.84254452723701 -0.175103223129959 0.477307079631389 -0.244330409318385 0.346020114135014 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HERPUD1 0.517680441487676 0.0737919151414431 0.443171240081545 0.46108064818047 0.11420644179297 0.4924007041452 0.073538786249847 1.0 -1.64407134664651 0.0058590655665405 1.21553830205676 0.0194264664718473 -0.428533044589752 0.365604397531261 reversed True False False False False False False 0 cross_species_direction_conflict +LIMK2 -0.462626670096982 0.0741948372631609 0.445337744073026 -0.268375251086987 0.295062284795704 0.652548722847306 0.505758332970968 0.192611453893234 -0.647761313279583 0.0615812784118935 -0.142002980308615 0.721836341391194 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF513 -0.69690864899914 0.0742801550453705 0.445383976957139 -0.591151170549621 0.13920192554244 0.524072738828147 0.4780243378984521 1.0 False False False False False False False 0 insufficient_or_context_specific +KRI1 -0.450451650976036 0.0742869088294679 0.445383976957139 -0.36729578655416 0.158983616193733 0.543060696740211 0.8376598947579259 1.0 -0.335468437260629 0.31738191177615 -0.542710927912366 0.0737264331957296 -0.878179365172995 0.0160952764241893 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PROC -1.16253109321248 0.074330789020386 0.445394137614776 -1.15204889489174 0.0774782133509831 0.456481571740893 0.4676423324128811 1.0 -1.48101698361472 0.0048991411542057 1.13375826829939 0.0145382876729609 -0.347258715315325 0.401510282050849 reversed False False False False False False False 0 insufficient_or_context_specific +LAT -0.527824641018662 0.0744100392684477 0.445616105840199 -0.278524886906119 0.379560656094846 0.716424065042321 False False False False False False False 0 insufficient_or_context_specific +MAP7D1 -0.483345352108524 0.0744858868180417 0.445739179385534 -0.311569998601048 0.264441266662289 0.627127334550864 0.5334410969138189 1.0 0.0369232513123084 0.919998302983937 -0.630228349619244 0.0246097042273639 -0.593305098306935 0.0379315479383679 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC073115.1 1.66979746686736 0.0745289477249624 0.445739179385534 0.946310182931481 0.248894265016855 0.614839880685063 True False False False False False False 0 insufficient_or_context_specific +TXNL4B 0.526457401828964 0.0745886285070601 0.445739179385534 -0.0805321860029024 0.792876137268116 0.927620871373898 -0.599332315919274 0.200608955311979 0.631516398498078 0.104012536189577 0.0321840825788033 0.946312202903686 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EFCAB6 0.460070138702253 0.0746710528961472 0.44591284483997 0.253438417780256 0.325416576164363 0.674724889947951 0.6482043209940171 1.0 True False False False False False False 0 insufficient_or_context_specific +BCAS2 0.65067820355292 0.0747630339494236 0.44591284483997 0.478203011862957 0.187354903542749 0.56929178900529 0.479458428781314 1.0 -0.0282719058559178 0.930819143190205 -0.0096158609695794 0.969574576769779 -0.0378877668254972 0.887567577618362 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DARS 0.378881942921729 0.0747811353833619 0.44591284483997 0.348228460989673 0.10292123359101 0.479239170340314 0.0950873262296146 1.0 -0.345910763137291 0.16037520975123 0.319125722067433 0.142337506413759 -0.026785041069858 0.92026295796161 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC01137 0.567976176201133 0.0748279392256395 0.44591284483997 0.523783237724102 0.103241866247181 0.47952541118609 0.6077532826060501 0.596652131284086 2.0 True False False False False False False 0 insufficient_or_context_specific +LRCH2 0.612223676237312 0.0748964769036089 0.44591284483997 0.412483641941598 0.239435086539 0.606713331305531 0.0459719198586769 1.0 True False False False False False False 0 insufficient_or_context_specific +TAOK2 -0.433556142340052 0.0749118278371254 0.44591284483997 -0.0329975761792415 0.891573454660391 0.965065212610968 0.113608612089383 0.712451439520194 -0.453922699071093 0.068871070498288 -0.340314086981709 0.177904366749501 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARID1A -0.259177623076512 0.0750706449229315 0.446504692181396 -0.177862164549132 0.23165125287004 0.601518427890281 0.315247996908214 1.0 0.166438179197236 0.504297082247917 0.133032832152066 0.512555893407162 0.299471011349302 0.166994010849468 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GGA3 -0.396735962573291 0.0751081959949004 0.446504692181396 -0.286471689921975 0.208135033723242 0.580731946630546 -0.0359166648257253 0.925007228165139 -0.35669008671647 0.161727491604316 -0.392606751542195 0.155017823097416 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FASTK -0.537641147385293 0.0752950532430718 0.446956345150849 -0.440591108672506 0.145648489634373 0.532658823056677 -0.110541497512862 0.669489701793598 -0.690009297426918 0.0065205800296926 -0.80055079493978 0.0052530463762208 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACVR2B 0.466901928267066 0.0753111704890472 0.446956345150849 0.404906270717123 0.119320820942944 0.499900248662619 -0.736377397632384 0.113589394754605 0.153167288297801 0.719051825447651 -0.583210109334583 0.171712210245408 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NMNAT1 -0.434960161623166 0.0754363825261124 0.447196702251934 -0.638623536606799 0.0048162418556379 0.261521011602645 -0.0211800565487275 0.956488298731866 -0.165973083572768 0.520179627167617 -0.187153140121496 0.512825763629788 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOL7 0.46412590152114 0.075527087500245 0.447232187228035 0.309351040269216 0.238876233037516 0.606415397271769 -0.400961632708674 0.443432375607839 0.988969155106695 0.0296841847653515 0.588007522398021 0.185853928434108 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NBPF15 0.363269577550448 0.0755836849036602 0.447281970216255 0.259321758572357 0.201130416348942 0.576108230008718 True False False False False False False 0 insufficient_or_context_specific +CHD7 -0.376817590476392 0.0758179825246507 0.447703344731042 -0.279407308794606 0.201114059005657 0.576108230008718 -0.437482751487261 0.0943550409468221 -0.0940332397489479 0.695406645460819 -0.531515991236209 0.0405196423106954 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CMIP -0.472968214166826 0.0759972438931397 0.448506931818764 -0.486387918451097 0.0668132081702811 0.436862290339161 -0.0329663458265189 0.928457635800105 -0.0612424004642172 0.817483029431813 -0.0942087462907361 0.737513676200414 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA0232 -0.393949356202369 0.0760641388332738 0.448650937319388 -0.333563926956288 0.137661506346595 0.523810858054217 False False False False False False False 0 insufficient_or_context_specific +PSME2 -0.94414876861951 0.0762229616843138 0.449085953941398 -0.536658663611206 0.342464513178469 0.689130402583821 False False False False False False False 0 insufficient_or_context_specific +CDO1 -0.835781847951235 0.076307172212003 0.44933135762093 -0.602991384670951 0.20439958615164 0.577482159643837 -2.14635905069068 0.0018824335441529 2.69886599213389 0.0009226106283564 0.552506941443213 0.258590560051675 reversed False False False False False False False 0 insufficient_or_context_specific +EIF2S2 -0.344060504440271 0.0765377570164214 0.449429609216431 -0.401659464962641 0.0357680829630419 0.37720666979567 0.5386291588193571 1.0 0.116121079706746 0.831324490282524 0.0931895034893654 0.81302075460589 0.209310583196111 0.625263825973805 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STRN4 -0.455764519266405 0.0765716253430169 0.449429609216431 -0.426423954319886 0.0998065931632082 0.478125555523304 1.58996330115538 1.0 0.134809366160754 0.637962343051058 -0.451352874090624 0.0592868602949863 -0.31654350792987 0.18869187142529 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UTRN 0.319971645353207 0.0765792637791588 0.449429609216431 0.309288460400245 0.0861956042304987 0.467677448123587 0.27407517000804 0.367896928839594 2.0 -0.0498698425931745 0.869189748977706 -0.186113642146088 0.379345629278086 -0.235983484739262 0.293338032684508 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SREK1 -0.354253468751688 0.0766351017604342 0.44950744688148 -0.29781454246498 0.142451059699682 0.528011532230573 0.401556869330044 0.0376795563216325 2.0 0.149246968656328 0.623560328393454 -0.647690476406217 0.0190902177267254 -0.498443507749889 0.0637592023533788 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EHD2 -0.488217304996134 0.0767766498634775 0.44983788527114 -0.0626408389355021 0.830628028240802 0.943790632272401 1.18123372443404 0.655425760649995 2.0 0.542041448779144 0.0686589550123795 -0.119331459662398 0.652865444711244 0.422709989116746 0.126073370134676 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASTN2 0.516694752359978 0.0769372665449345 0.449901704605287 0.362947939795996 0.219726634866926 0.592069212484543 1.31576339660511 0.063436389773099 2.0 -0.0968008167740975 0.79836475921007 0.263644920712529 0.339944367778569 0.166844103938432 0.582244804472554 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF276 -0.450267866322433 0.0769848024014965 0.449901704605287 -0.50184902531687 0.0449187506170296 0.393650849907072 0.274022658179282 1.0 False False False False False False False 0 insufficient_or_context_specific +MIR99AHG 0.509446162781752 0.076991588772366 0.449901704605287 0.469052268858131 0.106391360481986 0.483261130274234 0.6827243567434311 0.277870619305213 0.362985415666002 3.0 True False False False False False False 0 insufficient_or_context_specific +NAA16 0.268798848711231 0.0770006043021171 0.449901704605287 0.188692137226798 0.218030013892571 0.590436230426177 0.254364283352344 1.0 -0.027817216363069 0.942068767466077 -0.751512494066997 0.0135220884583565 -0.779329710430066 0.0171952829966986 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PTGS2 1.23274035438913 0.0771410831184336 0.450358356713327 0.922718094553497 0.178362903881798 0.561298223303732 True False False False False False False 0 insufficient_or_context_specific +AMZ1 0.5204597820037 0.0771640715376405 0.450358356713327 0.561758095714379 0.057489197463136 0.424455207563489 0.0293485424145258 1.0 True False False False False False False 0 insufficient_or_context_specific +HAS2 -1.3854117580415 0.0772321925302972 0.450506899853524 -1.36342296295919 0.0829896392556566 0.464508161442731 1.03096199057334 1.0 False False False False False False False 0 insufficient_or_context_specific +SLC6A13 -1.43503647259139 0.0775769836511415 0.451687681943918 -1.30943810230242 0.111993548503703 0.490430479096682 -0.320582156269218 0.54741955797745 0.377180489094579 0.383396975640311 0.0565983328253606 0.916468942306155 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MNAT1 0.276597000538948 0.0776057449371346 0.451687681943918 0.207068515286576 0.185552737410071 0.56775396895769 0.0898196731709648 1.0 -0.15011561163558 0.677860015872792 -0.132076175156501 0.646005891410354 -0.282191786792081 0.343401171080253 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BIRC3 0.717967819426569 0.0777860179238089 0.452332738609159 0.997194437040188 0.0152076367261473 0.320500116612027 0.277454986167908 1.0 -0.251679636390331 0.519022082221429 0.485861016059481 0.12309014354093 0.23418137966915 0.489239096297536 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LIX1-AS1 -0.864951049185638 0.0778022592644661 0.452332738609159 -1.20156928966566 0.010468789956722 0.302245517751671 False False False False False False False 0 insufficient_or_context_specific +PDHA1 0.459322426020546 0.0778888715881099 0.452587070020509 0.669443781975385 0.0071414108203221 0.285602331215763 0.0127823118774676 1.0 -0.368227760054156 0.259736012744498 0.795098450699246 0.013980003294206 0.426870690645091 0.150088242805064 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NADK2 -0.417376878547944 0.0779490255655996 0.452608944744489 -0.654863802431449 0.0051489015392929 0.265121723850427 0.284249094117464 1.0 -0.395420260457573 0.383064294041297 0.449309198826631 0.244528489266444 0.0538889383690573 0.910733265870861 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INTS2 -0.393895016864298 0.0781827896279788 0.452608944744489 -0.113575250089209 0.624142077342856 0.85594302057622 0.498851908119783 0.237794252655954 -0.38384866414111 0.25869808372257 0.115003243978674 0.795903287142716 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CEP57 0.353491606549564 0.0782232941075898 0.452608944744489 0.285934658598093 0.156637273987732 0.539558215777 0.33867404255496 1.0 -0.0838930174489539 0.862981521576469 -0.22998497650044 0.493283724787594 -0.313877993949394 0.388814244083847 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ERAP2 -0.499034753274555 0.0783554201592959 0.452608944744489 -0.332860048776692 0.243999100674977 0.610315684654444 0.618241771997753 1.0 False False False False False False False 0 insufficient_or_context_specific +TAF6L -0.47223819748337 0.0784027583388272 0.452608944744489 -0.510320135052602 0.0562050138272174 0.423380157386529 0.207049308353681 0.694161922382797 -0.755391536356176 0.0683482628446471 -0.548342228002495 0.230651510087892 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCARF2 -0.524480616626098 0.0784454569844925 0.452608944744489 -0.338337575911677 0.279615617374453 0.642114507827558 0.9868453051578879 1.0 0.150523867451138 0.694008504879575 -0.577360921826865 0.0657570597316969 -0.426837054375727 0.178919164020884 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EMC1 -0.49580029500766 0.0784591855056796 0.452608944744489 -0.531004625383817 0.0581894353196585 0.426938191872796 0.0518393461351113 0.861352113077705 -0.0372722296173494 0.874909210988476 0.0145671165177618 0.95468228973023 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ELOA-AS1 0.692260803759255 0.0785076496542197 0.452608944744489 0.282610141597534 0.474509898846836 0.776724885585255 0.0312436464933235 1.0 True False False False False False False 0 insufficient_or_context_specific +PIP4K2B -0.369715827120459 0.0785296628731245 0.452608944744489 -0.435715785218541 0.0355859413257759 0.37720666979567 0.432565805640923 1.0 0.360909311719375 0.249314436019167 -0.182447919541882 0.489891573066962 0.178461392177492 0.552563900497758 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TAP1 0.719916738568729 0.0785334819666752 0.452608944744489 0.683834303882373 0.0935744170111787 0.473775578029617 0.292564792363323 0.0266450289380114 2.0 -0.0801244759381907 0.833338945112215 -0.412637196014176 0.131130448489036 -0.492761671952367 0.0950999042448387 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IFITM10 -1.25440672116112 0.0785356683815026 0.452608944744489 -1.39032701672149 0.0484382809524307 0.403191887129892 0.331281308520858 1.0 0.84370675532956 0.0629657500260124 -1.92100173541949 0.0014550940008916 -1.07729498008993 0.0369148994115098 reversed False False False False False False False 0 insufficient_or_context_specific +SLC30A10 -0.887801305515703 0.0786607704806543 0.452835558743047 -0.942144255173646 0.0607800417232 0.429268745755419 -1.3684813783644 0.0357078300728157 1.20449346172736 0.0403242141622078 -0.163987916637038 0.7892915505659 reversed False False False False False False False 0 insufficient_or_context_specific +ING4 0.413742500286283 0.0787131395806707 0.452890096835271 0.116413968549532 0.624621989118297 0.856338486330344 0.125587378659371 1.0 -0.0332608131051969 0.917089002819725 -0.435128117583377 0.0553091187388057 -0.468388930688574 0.0511892720219013 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RSRP1 0.375801433154572 0.0787939747606803 0.452986618787476 0.12076453912573 0.588403811682034 0.835590841220889 0.6601315762777691 0.683160524221601 2.0 -0.415206267445992 0.224256993413374 -0.920829432385827 0.0108050520501676 -1.33603569983182 0.0034891803832615 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GRB2 -0.255643992898126 0.0788530421428345 0.452986618787476 -0.197309054958613 0.185075106545632 0.56688091891009 0.000254233449301089 1.0 -0.0671546861460129 0.862121950436023 0.481851767058726 0.072076198489853 0.414697080912713 0.143316512559321 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC025809.1 0.466024362890053 0.0789719167380369 0.452986618787476 0.197183946160695 0.473733098694709 0.776295833620787 True False False False False False False 0 insufficient_or_context_specific +BAZ1B -0.289501017398635 0.0790136206536911 0.452986618787476 -0.12615070948467 0.470135723512148 0.774115985605889 0.225789143189537 0.350440762710423 -0.453079781836849 0.0422907843958007 -0.227290638647312 0.300805853065892 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIQK 0.439788333170015 0.0790536411768812 0.452986618787476 0.353313221241452 0.159217542484113 0.543060696740211 -0.813084386574959 0.52712239622571 0.458426279624811 0.656421353176508 -0.354658106950147 0.760011023969434 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TBPL1 0.53974548492842 0.0791003586968376 0.452986618787476 0.119293139966761 0.703591282772574 0.891778723110784 0.282555179457052 1.0 -0.0107467224876872 0.978775837181156 -0.178365736284334 0.506301850791576 -0.189112458772021 0.526216971156108 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IDH3G -0.521863159583265 0.079178641493697 0.452986618787476 -0.411386377121649 0.181619837466475 0.564332404732057 -0.200450514285393 0.426284439187468 0.242316204368072 0.248768076930928 0.041865690082679 0.871358595319376 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IFT140 0.364007063872842 0.0792021627424855 0.452986618787476 -0.0312569019600595 0.884576445355583 0.963081098449005 0.28852842626321 1.0 0.0350971425484207 0.950029058814111 -0.594806957656828 0.1167268963665 -0.559709815108408 0.177135032157865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HSPA1B 2.10872847146571 0.0792671740209462 0.452986618787476 2.21819243819608 0.066095566097767 0.436071024157137 2.54807705005597 0.139657490693448 2.0 -0.163908889734559 0.865601843682601 -0.890394168604476 0.198839621369912 -1.05430305833903 0.155853346939818 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KMT2B -0.412305774632984 0.0792837369661638 0.452986618787476 -0.4138302613433 0.077904338857925 0.457322349441485 0.327936953947956 1.0 0.061570583676904 0.843696053451533 -0.761649422794756 0.0060349363502649 -0.700078839117852 0.0131086841178374 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC090517.4 0.482201360070563 0.0792876748929016 0.452986618787476 0.411486385068448 0.137437404976093 0.523810858054217 True False False False False False False 0 insufficient_or_context_specific +C17ORF67 -0.584106811315855 0.0793346795826383 0.45301003084559 -0.595526006571584 0.0736220800405966 0.45226529445681 False False False False False False False 0 insufficient_or_context_specific +ZNF44 -0.394952449413461 0.0795072575170109 0.453439853433547 -0.30823575982581 0.194872371062417 0.571343735852293 False False False False False False False 0 insufficient_or_context_specific +C1R -0.391865987042599 0.0795174675706934 0.453439853433547 -0.371330587073855 0.0966610277573278 0.477364833333916 0.347891877885746 0.527799699993202 2.0 False False False False False False False 0 insufficient_or_context_specific +MARVELD2 -0.836843809332191 0.0797301692103895 0.453745592048269 -0.528685853028896 0.293760096249337 0.652324662738756 -0.277676287769557 0.689295545559026 0.15597400383189 0.772742606939621 -0.121702283937667 0.848856992637175 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PARP10 -0.769470048479579 0.0798227402890276 0.453745592048269 -0.862357423822008 0.046880814976534 0.399450754777127 1.29325380867941 1.0 -0.0209771100395564 0.953855717994412 -0.88563570131017 0.0051091206920605 -0.906612811349727 0.0068819745073034 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIPOX -0.924802978137945 0.079850803645106 0.453745592048269 -0.95399289844274 0.069805613314971 0.441586378298061 -0.719568230086322 0.0578228211960106 1.01628698102961 0.0097551386355733 0.29671875094329 0.38413601610362 reversed False False False False False False False 0 insufficient_or_context_specific +DNAJC11 -0.319840908528261 0.0799976781847138 0.453989366303662 -0.396553867524874 0.0276662730226125 0.361656300887855 -0.25206839086152 0.437418490395925 -0.162114690628023 0.556860346437624 -0.414183081489544 0.154165803758607 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IDH3A -0.479643855236756 0.080050394271716 0.453989366303662 -0.204485605274011 0.46736345766621 0.77233109814366 0.5098145104203929 1.0 -0.096370415532469 0.791788714793757 0.341652515636557 0.192152850042874 0.245282100104088 0.382954015332693 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM254 -0.581158377079546 0.0804268527236113 0.454575327117713 -0.500448945947803 0.135949334766843 0.523136620282319 False False False False False False False 0 insufficient_or_context_specific +NAPRT -0.82129486975284 0.0806525414602123 0.455363386490333 -0.59805461670352 0.222688224550203 0.593722796666929 0.277155495172948 1.0 -0.771753097656493 0.0179374267520533 0.32118836744765 0.231950620293141 -0.450564730208843 0.114059672677102 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUBP2 -0.464516919336209 0.0807361702042913 0.455591921441426 -0.500504504429385 0.0580506610685012 0.426512790230505 0.372906211042909 0.31057796670795 0.174957874532883 0.571680174041535 0.547864085575792 0.10610738150025 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC025682.1 -0.282277595585306 0.0808207795490673 0.455753473138119 -0.327193612451828 0.0374054435903043 0.379484931484566 False False False False False False False 0 insufficient_or_context_specific +LPIN1 -0.395852666415243 0.0808511323345043 0.455753473138119 -0.412982983185411 0.0677735843837444 0.43786261079484 0.108386826761418 0.50597975373138 2.0 -1.90849782961895 0.0876289555088389 1.91587463855548 0.0623392835954343 0.0073768089365383 0.99567200213619 reversed False False False False False False False 0 insufficient_or_context_specific +SUGP2 -0.313796129265873 0.0810894908954966 0.45678312590043 -0.293488855564087 0.102241626098782 0.479137456027696 0.587388057409861 0.0365987969451001 -0.332095219461988 0.154864694350096 0.255292837947873 0.313216863869445 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF197 0.377705835535956 0.0812171867573044 0.45678312590043 0.255000374983787 0.227851658834619 0.600160304082166 0.0342536841538677 1.0 True False False False False False False 0 insufficient_or_context_specific +GAS2 -0.824264220252812 0.0812208186639752 0.45678312590043 -0.84091432560955 0.0752775200087637 0.453382804479479 -0.33822847955669 0.433677507513499 0.553704107372064 0.124375682086726 0.215475627815374 0.583431841673202 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL133523.1 -0.654610151592615 0.081256285624875 0.45678312590043 -0.483004780733844 0.208641338051225 0.58089116165231 False False False False False False False 0 insufficient_or_context_specific +SMG9 0.407176960378509 0.0812992314275599 0.45678312590043 0.520673885228255 0.0205486453290909 0.333389311130767 -0.258284093973643 0.603226373915281 -0.112511947415555 0.7884615540991 -0.370796041389198 0.3816386514685 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF583 0.538632967113137 0.0813864511348817 0.45678312590043 0.436988050775542 0.156736602366742 0.539558215777 0.547769816070335 0.604559910525104 2.0 True False False False False False False 0 insufficient_or_context_specific +LRRC17 0.58342803760566 0.0813901121136374 0.45678312590043 0.408999871536147 0.222057711633831 0.593397884800048 True False False False False False False 0 insufficient_or_context_specific +DDX59 -0.383866354432015 0.0815761338872122 0.457293088521646 -0.313889642248001 0.16107032220684 0.543541307772207 0.347022569849011 0.647748496092696 -0.275164278715994 0.612661579609855 0.0718582911330165 0.925408515234466 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP13 -0.557911887427136 0.0816006988799755 0.457293088521646 -0.578388975841873 0.0708703227091956 0.443801226075734 -0.190582288632388 0.817620155018848 -0.656697579675754 0.26837299336607 -0.847279868308142 0.20233502858456 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP10D 0.551745641459837 0.0816772700263115 0.457428892751606 0.559877234504753 0.0772415931229559 0.455668688469891 0.271759987136933 0.115626932771869 0.0816573093812022 3.0 True False False False False False False 0 insufficient_or_context_specific +TSSC4 -0.806542895639116 0.0817549081854784 0.457428892751606 -0.5779374846234 0.234041009354858 0.603018788225434 -0.284189725016129 0.323574977808632 -0.515847389460492 0.0517846739326563 -0.800037114476621 0.0126766940351296 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC02256 0.32702264504753 0.0818989776683982 0.457992270245205 0.162853677258144 0.412377291392024 0.735291083225579 0.11022421798469 0.074033233707639 2.0 True False False False False False False 0 insufficient_or_context_specific +RBMS3-AS2 0.902395483934581 0.0819966064321483 0.458153508965874 0.920219173577364 0.0765156555064434 0.455668688469891 0.0648698580011933 1.0 True False False False False False False 0 insufficient_or_context_specific +RING1 -0.423591789162695 0.0820324281591256 0.458153508965874 -0.370239202737102 0.129305842688644 0.51401019845885 -0.250270966230143 0.254771541846249 -0.384443874843961 0.0581972408242504 -0.634714841074104 0.0106848999908977 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MBD3 -0.568304039738256 0.0820957131644896 0.458153508965874 -0.521886097629854 0.111914762795502 0.490288823898305 0.759445535162565 1.0 -0.0784344433688624 0.835744129393262 -0.130180932067849 0.641822537524075 -0.208615375436712 0.46503773726748 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARID5B 0.629160323834639 0.0823404890006735 0.458585841408647 0.261342352929789 0.505587204935547 0.792927764365643 0.287308723696671 1.52594772121234 0.121928683636448 3.0 -0.584639799386063 0.192174733359028 0.361760516380324 0.358442439635704 -0.22287928300574 0.604803718536538 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WARS2-IT1 1.10158723691455 0.0824055276871956 0.458585841408647 0.437133736474166 0.483291540634052 0.780666906162311 0.7786060996711741 0.354924780339314 0.0194780737497356 3.0 True False False False False False False 0 insufficient_or_context_specific +AP2A2 -0.375710877168616 0.0824286205960844 0.458585841408647 -0.508711158933138 0.0142587075360189 0.316089554819539 0.7068104638806779 0.2926910904899411 2.0 -0.163268168432044 0.570470724300279 -0.145084623720678 0.540902885937713 -0.308352792152722 0.208694542832585 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM107B -0.471222236950224 0.0826499744906515 0.458585841408647 -0.582232909786673 0.0308489459406733 0.375031405408838 0.708119984241249 1.0 -1.24228265448586 0.0025660399388253 0.895619969723119 0.0107088437164944 -0.346662684762743 0.251949039866127 reversed False False False False False False False 0 insufficient_or_context_specific +TUBGCP3 -0.232714574373711 0.0826677030585191 0.458585841408647 -0.169707231023611 0.218315687975685 0.590550589518236 0.122139733208553 0.687089140579939 -0.213604773205882 0.359831464488724 -0.0914650399973291 0.736211293595013 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB17 -0.946958614853167 0.0827400988700091 0.458585841408647 -1.1121366998068 0.0388463827877064 0.379484931484566 0.862006454572659 1.0 -0.647373308558104 0.151884868967946 0.485661296369269 0.197877699633517 -0.161712012188835 0.70983486516815 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NSD1 -0.294309305882358 0.0827435863548896 0.458585841408647 -0.03738882629055 0.839507842113282 0.94849732986635 0.399578496007155 1.0 0.296379615011593 0.270026448052221 -0.395525026498811 0.0993388370109791 -0.0991454114872187 0.709907780430773 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXL4 0.347025464821146 0.0827660337873701 0.458585841408647 0.336076390163729 0.0927812601100397 0.472689102082201 -0.0482957039020881 0.917945009132389 0.290050755895298 0.328829657872091 0.24175505199321 0.465145531743413 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TDRD7 -0.321456990984478 0.0828124460834196 0.458585841408647 -0.183360309615759 0.342079070280553 0.689130402583821 -0.215922548664456 0.4838948928448 -0.251031859166445 0.322839005017478 -0.466954407830901 0.0937476557910336 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTSZ -0.531655133752473 0.0830353716334612 0.459037065463974 -0.40629529313967 0.203247857257121 0.576835372560841 -0.20362879983364 0.599670723393398 0.515913628183183 0.105249866899358 0.312284828349543 0.339441398391788 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCIRG1 -0.75192366662079 0.0830482175271868 0.459037065463974 -0.910379506077691 0.030477798145482 0.374622380904833 0.53562034745396 0.176454546814933 -1.05448676311085 0.0111657045125426 -0.518866415656886 0.162868871379868 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPS8 0.426570695461375 0.0830586271665617 0.459037065463974 0.344762347898339 0.160013825556034 0.543541307772207 0.7039396127239649 0.0936061996575215 2.0 -0.362361663776668 0.335562839037592 0.198816446417389 0.547408982264838 -0.163545217359279 0.651771076480977 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL157832.3 -0.473917607823945 0.0831098359405021 0.459037065463974 -0.373484020140622 0.179370628770362 0.562457706729278 False False False False False False False 0 insufficient_or_context_specific +ABHD3 0.300798726132431 0.0831687280337123 0.459037065463974 0.156869968306256 0.367330712287052 0.708317354196916 -0.709416737137167 0.0703443217228056 1.13347917303409 0.0063741880412067 0.424062435896921 0.223301394602426 reversed True False False False False False False 0 cross_species_direction_conflict +CEBPD 0.542736950984712 0.0832162287647326 0.459037065463974 0.0377856821412929 0.907202481360141 0.971275673886815 0.5818857487280821 1.0 -1.1008814050476 0.003091207359983 0.965705107650625 0.0054961617390721 -0.135176297396978 0.655316934567585 reversed True False False False False False False 0 cross_species_direction_conflict +CTC1 -0.566377116261419 0.0835210372561571 0.459372030894287 -0.784756798562023 0.0137167420002656 0.314756631908661 0.409365707755299 0.320349903765884 -0.492003963395919 0.14237544238686 -0.0826382556406208 0.851524650863614 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IER2 -0.652331854061822 0.083543660845837 0.459372030894287 -0.655389874352655 0.082299642605917 0.462431570888118 0.586864035545926 0.282767697719781 2.0 -1.23742300656857 0.0733914383402823 0.625725104073515 0.297954127258904 -0.611697902495055 0.321406463935889 reversed False False False False False False False 0 insufficient_or_context_specific +SH3TC1 -0.634549678971352 0.0835815184076459 0.459372030894287 -0.760445867307039 0.0315722293883003 0.375031405408838 0.147929567444145 1.0 0.174374960998769 0.694695086497373 -0.0646185956106762 0.861062288367012 0.109756365388093 0.787352908909493 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC58 0.448107338661081 0.083916349225209 0.460216624403445 0.226964795813024 0.36955482277521 0.709345639075664 0.453979716813622 0.0418461311497697 2.0 -0.0342911061737161 0.922324480025494 -0.42913867464636 0.0810809258185391 -0.463429780820076 0.0761110811469107 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC009948.1 0.414010177530517 0.0839766370475629 0.460216624403445 0.614202429834998 0.0129460517214317 0.313114831651016 True False False False False False False 0 insufficient_or_context_specific +TMEM185A 0.462065321214968 0.0840126833822673 0.460216624403445 0.297969293760788 0.259291415161068 0.622885940784012 -0.123788212771021 0.806638059482639 0.709482745826071 0.0429143066329857 0.585694533055049 0.115597349395428 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NDUFV3 -0.346031867268055 0.0840352126893168 0.460216624403445 -0.382285453782655 0.0532654292294436 0.416631456505827 -0.633252025984293 0.0725294217860142 0.358458563832242 0.244477329952329 -0.27479346215205 0.39513302829562 reversed False False False False False False False 0 insufficient_or_context_specific +STARD7 -0.399613848213231 0.0841703416189486 0.460216624403445 -0.525841527158091 0.0177036579000657 0.326204572615871 -0.16535948150458 0.61895429282793 0.25546992658037 0.3328349381822 0.0901104450757898 0.769417641581309 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DPH7 -0.424217635100113 0.0841748105813412 0.460216624403445 -0.235779787271981 0.371182144637289 0.710081732756023 0.517169197754949 1.0 -0.0853305212064262 0.877257768957367 0.332693621923551 0.348177805438361 0.247363100717125 0.547463821143268 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTC7B -0.297459165538663 0.0842368508638893 0.460216624403445 -0.103764365902486 0.559306614336973 0.821846488287693 -0.192279240878201 0.423793007895288 -0.17628613156149 0.384797495970405 -0.368565372439691 0.0931698863344416 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AR -0.861124754491733 0.0842935412387594 0.460216624403445 -0.844002811275671 0.091199826419492 0.472234212482528 -0.943162585501496 0.233658535785586 1.10605889397096 0.0810809258185391 0.162896308469464 0.822378917549632 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAD52 0.382218043416539 0.0843317919254052 0.460216624403445 0.159698657117586 0.477253951815973 0.778537650801879 -0.0900850486234757 0.883206679897385 -0.512399818511118 0.218093755564158 -0.602484867134594 0.190882837445384 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BCL2L1 -0.298911971577603 0.084408361151218 0.460216624403445 -0.399350709206936 0.0179150013094924 0.32629129734252 -0.559521602493528 0.147791978844453 0.210703577690509 0.543223787997289 -0.348818024803019 0.325978709915503 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRSF4 -0.252602835812092 0.08446451128713 0.460216624403445 -0.289952969788188 0.0451068060115489 0.394236471746634 0.439044091486716 1.0 -0.0924670485437267 0.751798143959638 -0.183548408412369 0.403679171002468 -0.276015456956096 0.232232193240595 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1ORF112 -0.384677582925149 0.0845924256675206 0.460216624403445 -0.164942148683977 0.464976601902851 0.770315857977452 False False False False False False False 0 insufficient_or_context_specific +SCMH1 0.312462487924974 0.0845962773189875 0.460216624403445 0.398925570961892 0.0239473169960395 0.348898908348731 0.417210614879346 0.38077154041074 0.0778485188253921 3.0 -0.119615674469372 0.762697108326793 -0.0567761847159361 0.860542530892141 -0.176391859185308 0.590034275997834 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SRP14 0.754383165753077 0.0846098987328366 0.460216624403445 0.783847328080381 0.0742815383618437 0.452862231765951 0.322063856427238 1.0 -0.0480231761721271 0.894007251621826 -0.0250288566297097 0.930852252028654 -0.0730520328018368 0.801697886046002 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HLA-F 0.658073296715893 0.0846339670526545 0.460216624403445 0.434867463616454 0.257900723063651 0.621906676979798 True False False False False False False 0 insufficient_or_context_specific +AC099687.1 1.05902301255363 0.0846513186378006 0.460216624403445 -0.33596152495036 0.586432012053396 0.835228542190714 False False False False False False False 0 insufficient_or_context_specific +GALNT15 1.24317648690937 0.0847116178383984 0.460216624403445 1.03848161875885 0.145494018243497 0.532658823056677 0.720165627795625 0.7033807616591391 0.050443544830475 3.0 -0.7312123359168 0.293843453845735 0.940057546475865 0.0893599721937684 0.208845210559065 0.740569802248928 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BAIAP2 -0.887247237657964 0.0847377455806306 0.460216624403445 -0.997572078390199 0.0479889024910165 0.402009816708327 -0.425590775318588 0.156511497156519 0.158099734684273 0.554374722086723 -0.267491040634316 0.332646961763079 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL391839.1 0.704974865671063 0.0848432876716334 0.460316254489776 0.721784253807255 0.0789166237762827 0.458237364234745 True False False False False False False 0 insufficient_or_context_specific +TRIP10 -0.406287842752368 0.0850207918993588 0.460913302706067 -0.478239809608534 0.0396767750974622 0.381171420818022 0.4202461403093979 1.0 -0.164537312466769 0.647352963989451 -0.512930271520593 0.081826169912488 -0.677467583987362 0.0374816418574883 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC104806.2 0.53806245880856 0.0850711148352096 0.460913302706067 0.257016928831828 0.395524982527753 0.726526152518217 True False False False False False False 0 insufficient_or_context_specific +PPM1B 0.368449082997816 0.0850842988230844 0.460913302706067 0.110280548405663 0.606862080084323 0.846931578987574 0.0708387246874587 0.0701006373892075 0.0848611061289503 3.0 -0.0072255208040712 0.987737852304143 -0.0063474566442334 0.986614719437986 -0.0135729774483047 0.972198914473462 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FXR1 0.295958755534543 0.0852963212793448 0.461588190705957 0.176420144371969 0.327095744079053 0.676489102054191 0.0751708191700017 1.0 -0.0173054070952026 0.95834264814358 -0.411767844320602 0.0822633539299025 -0.429073251415805 0.0860111326248824 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HACE1 0.389839254793645 0.0855485483966946 0.462479044532669 0.36964897941977 0.102747137180042 0.479239170340314 -0.0779426019410091 0.87728135326858 -0.40590558597725 0.237194712289171 -0.483848187918259 0.203044110873764 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EYA3 -0.346671132832236 0.0857385191504731 0.463031859432581 -0.129800404572321 0.504522054308134 0.792758405693685 0.30056407483288 0.342368947167019 -0.0982778621237296 0.720560790058018 0.202286212709151 0.490123065276328 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGDIA -0.606641984138724 0.0860549083928681 0.463815671176355 -0.407101848368668 0.27320935418098 0.637071187742661 0.896375930478245 0.5062243403927129 2.0 0.0439635931002213 0.895560263778032 0.24208177826094 0.289544412864251 0.286045371361161 0.236334419408948 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUDT22 -0.532978549806333 0.0861463952262075 0.464047775917499 -0.723562039555708 0.0131309001609067 0.313114831651016 -0.253719429071615 0.483025959043426 -0.120802828333808 0.695406645460819 -0.374522257405423 0.238428067354561 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPHA2 -0.547186346159551 0.0862406287178061 0.464095198907497 -0.316380605334039 0.327483782556105 0.676889991422347 0.31339646453008 1.0 0.266793044129842 0.46104734065596 -0.0407830587489854 0.907519148181617 0.226009985380856 0.485530043142729 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF444 -0.523288507335553 0.0863310258244293 0.464095198907497 -0.668848281092986 0.0250388476997276 0.351006805738558 0.4131502407372961 0.386178470974976 2.0 False False False False False False False 0 insufficient_or_context_specific +C6ORF203 -0.464222926209481 0.0864278083821974 0.46414282853471 -0.326848854154467 0.22319149905189 0.594234827022923 False False False False False False False 0 insufficient_or_context_specific +ADAMTS13 -0.615074655269125 0.0868416120343167 0.465327814291346 -0.730304780594679 0.0388823153743299 0.379484931484566 False False False False False False False 0 insufficient_or_context_specific +NT5C3B -0.450812740843667 0.0869015345498612 0.465327814291346 -0.276596056822952 0.31446023308179 0.666840881022273 -0.27061132077097 0.415382455534496 -0.33342249905617 0.230683887481437 -0.604033819827139 0.0559228447713581 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF205 -0.645003364936864 0.0869129048856349 0.465327814291346 -0.679092890700337 0.0693534920533625 0.441104921144217 False False False False False False False 0 insufficient_or_context_specific +ARHGEF40 -0.445129228389114 0.0870287101120165 0.465711668202063 -0.247213379685606 0.362624319700315 0.704431935123446 -0.161466153790472 0.591076204481562 -0.19647292015835 0.419860208981978 -0.357939073948822 0.162148425910995 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SUPT5H -0.407104700100176 0.087226547627931 0.466131832446229 -0.479015923210833 0.0416442858119025 0.390826995201837 0.7503051043223341 1.0 False False False False False False False 0 insufficient_or_context_specific +SDK1 0.576255549389973 0.0874565677733894 0.46650493983352 0.371694747126488 0.265736406213424 0.62822323708046 0.157550615620249 0.108589081943709 2.0 True False False False False False False 0 insufficient_or_context_specific +HDAC6 -0.492246152322389 0.0874862455834789 0.46650493983352 -0.433476151784342 0.136600291614139 0.523136620282319 0.334933508529141 0.422004520516216 -0.159712443114687 0.634251779652164 0.175221065414454 0.661583494154176 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AUH 0.320687951070094 0.0875881711151845 0.466812675736556 0.207121376479854 0.271978535959027 0.635912471173671 -0.202419548369435 0.415856830616875 0.115965610139995 0.588474661507159 -0.0864539382294403 0.717583743072501 partial_or_other True False False False False False False 0 cross_species_direction_conflict +STAM 0.410482229519906 0.087748689121434 0.467196500123096 0.422906202136072 0.0781806314262783 0.457322349441485 0.0532774299691105 1.0 -0.410320392092957 0.320505518455542 -0.119996236007714 0.752040433719446 -0.530316628100671 0.162428526863777 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GSTP1 0.789556884860318 0.0878144416647814 0.467310924947964 0.269090121642323 0.545021230349864 0.81520013063734 -1.08000151297193 0.144258976138882 1.43933994585993 0.0420192962565403 0.359338432888005 0.610519401148144 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MIPEP 0.534124561354529 0.0879320347518401 0.467465469743166 0.574094076376986 0.0653537695959608 0.435533238803682 -0.120359257334603 0.718932829581798 0.519043585046807 0.0497435923782537 0.398684327712204 0.14001483845773 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLEKHN1 -1.02831412264867 0.0880830389810759 0.46779714565503 -0.864844239914756 0.163128421769944 0.544298760692042 0.108611415244554 0.745995021322483 -0.562357597794754 0.039110718478162 -0.4537461825502 0.100502560869296 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAF3IP2-AS1 0.482436258533333 0.0883621042899502 0.46849033903599 0.426254557385386 0.136660688660287 0.523136620282319 0.148388219877366 0.0846701831216508 2.0 True False False False False False False 0 insufficient_or_context_specific +OBSCN -0.603356664149481 0.0884617658500303 0.468615222083178 -0.472034509532339 0.188236533648949 0.56929178900529 False False False False False False False 0 insufficient_or_context_specific +AL662796.1 -0.667176122034337 0.0885553603510996 0.468615222083178 -0.253405523055044 0.54251347277725 0.814310100310237 False False False False False False False 0 insufficient_or_context_specific +SGSM2 -0.397408035332548 0.0886249524703325 0.468615222083178 -0.130780196536826 0.578447610115353 0.831144511104776 -0.42833066505554 0.30700561749008 -0.439414293240039 0.228212430991369 -0.867744958295579 0.0396757426500509 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CERS6 0.572436721784671 0.0886365408694929 0.468615222083178 0.413532255980705 0.219546323062539 0.592069212484543 0.60586531865165 0.0975143711677173 2.0 -0.165300291217862 0.674273152012007 -0.253164353620482 0.397852828334116 -0.418464644838344 0.200097280541583 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM168A 0.415913451234118 0.0887748981124541 0.468877125698494 0.565564178157204 0.0176876185246081 0.326204572615871 0.294564337974101 0.123363688697977 0.116223145761511 3.0 -0.427464731719948 0.113513091730408 -0.008724019500046 0.974423910121543 -0.436188751219994 0.0886049560590421 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRUNE2 0.972124571945591 0.0889341777396162 0.469483524287434 1.37968444099441 0.0154601134855113 0.320853404849916 1.16256473735172 0.0519269189542692 2.0 True False False False False False False 0 insufficient_or_context_specific +AL117339.5 0.620023737936763 0.0890779285864673 0.469691572667049 0.263105717800485 0.459811519279112 0.768558565184993 True False False False False False False 0 insufficient_or_context_specific +HUNK -0.680297462407351 0.0891083785807644 0.469691572667049 -0.55579885020711 0.167698788185874 0.547623080618609 0.189488473249672 0.784039873542692 -0.823258751082048 0.106630624482327 -0.633770277832376 0.273219007933399 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SHANK2 -1.12757662862639 0.0891515354825502 0.469691572667049 -1.18895179623295 0.0720280602333848 0.447336623496516 -0.547046230708287 0.266795725680517 0.0352893718547206 0.942453793335698 -0.511756858853566 0.253728124196861 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STYX -0.387613010991267 0.089249300725157 0.469970940592466 -0.309522981171379 0.178624823613957 0.561600025036498 False False False False False False False 0 insufficient_or_context_specific +FBXL13 0.533921915703249 0.089508455036835 0.470445927545975 0.686505270987681 0.0274274119271501 0.36062094038213 0.0294186526748748 1.0 True False False False False False False 0 insufficient_or_context_specific +PDCD7 -0.35089944393078 0.0895175097972972 0.470445927545975 -0.318366867432644 0.125905850479001 0.507996233320616 -0.261006704843646 0.361077875409092 -0.69849029622107 0.0147774568251412 -0.959497001064716 0.0056360310187644 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HAUS8 -0.573566544122715 0.0896341972860631 0.470775766926124 -0.673317850047081 0.0436495640814205 0.392214551124798 0.833535214642598 0.0995701591106681 -0.998319006192817 0.0268000316303021 -0.164783791550218 0.769026048029419 reversed False False False False False False False 0 insufficient_or_context_specific +PFN1 -0.541701808913937 0.089714040827369 0.470775766926124 -0.311246391284868 0.346227797703959 0.691407809373633 0.311194699205701 1.0 0.333400055577137 0.330533284742075 -0.382740517873687 0.199119174711486 -0.0493404622965505 0.893102493173388 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL603840.1 1.21098564736855 0.0897761834104109 0.470867831319979 1.25468917995008 0.0802756372222426 0.460352677246087 True False False False False False False 0 insufficient_or_context_specific +MRPL41 0.544916772918939 0.0898445648744696 0.470992510399529 0.533672552148096 0.0978695863877284 0.478125555523304 True False False False False False False 0 insufficient_or_context_specific +POLE -0.398700503702595 0.0901606027417374 0.472180378842888 -0.260142095508871 0.274927994515503 0.638427515212424 2.36055353180311 0.0106148402583479 -2.46000875063811 0.0039346027644 -0.0994552188349985 0.934929016521663 reversed False False False False False False False 0 insufficient_or_context_specific +SAMM50 -0.391268418592747 0.0902972946733955 0.472516553220582 -0.560218980727523 0.0112912218894609 0.302570357129259 0.26480388296034 0.372867518414602 0.147402186720462 0.561246965825296 0.412206069680802 0.126102409810385 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GAPDH 0.509398901739726 0.0904150695997603 0.472809462523165 0.671587968438438 0.0253953340123314 0.351006805738558 0.241674334469752 1.0 True False False False False False False 0 insufficient_or_context_specific +ARFGEF2 -0.221490334755412 0.0904612510341591 0.472816776444877 -0.167234603717768 0.20981709084119 0.581956585220706 -0.0761175425171883 0.838199516473168 -0.439333342589477 0.10257906005202 -0.515450885106666 0.0773433060787048 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL365273.2 0.925228840228054 0.0905435205269361 0.473012612431168 1.26074131905613 0.0216856389132053 0.342749963541349 0.0486751256891421 1.0 True False False False False False False 0 insufficient_or_context_specific +PEX3 0.388589960425922 0.0906844102880012 0.47312329130067 0.434323302532202 0.0585979354912344 0.427854082238211 0.0331943550154756 1.0 -0.550584566563275 0.268302181913368 0.0922795585503635 0.845719498158638 -0.458305008012911 0.310559571769645 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SSBP1 0.440570786763765 0.0908939957504255 0.47312329130067 0.418274655675938 0.107241699288816 0.483286684531078 0.0252006274396143 1.0 -0.133695730542186 0.615157287070527 -0.138085708791206 0.519110801759597 -0.271781439333393 0.224912246829819 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SGPP1 -0.302205704878121 0.0909362216057612 0.47312329130067 -0.29584123463109 0.0981081640160206 0.478125555523304 -0.129766373530019 0.706122720126662 0.298010136633014 0.259825333612605 0.168243763102995 0.563000775166288 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP003555.3 -0.68109921188509 0.0909930003037494 0.47312329130067 -0.844827254998487 0.0328820518091052 0.375130164525249 False False False False False False False 0 insufficient_or_context_specific +DPYS -0.872966740053264 0.0910282903831375 0.47312329130067 -0.774144167695567 0.136666783685763 0.523136620282319 -1.41523899219339 0.0231079985556558 2.03965815449937 0.0035348053528574 0.624419162305988 0.231197625367436 reversed False False False False False False False 0 insufficient_or_context_specific +CBWD2 0.427232022381315 0.0912596411663417 0.47312329130067 0.545609319204648 0.028784899269779 0.368376929079184 True False False False False False False 0 insufficient_or_context_specific +HDAC4 -0.298418479233922 0.0913930035095795 0.47312329130067 -0.262513567237033 0.138535681649893 0.523810858054217 -0.0360266784763505 0.918157951904821 -0.398956362547292 0.098929251676969 -0.434983041023642 0.0934465566630974 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KNOP1 -0.405672842997423 0.0914355830715075 0.47312329130067 -0.130572428281144 0.587355207928958 0.835274227991216 0.350614928926649 1.0 0.218917361500447 0.577921130285763 -0.115676506201867 0.713552252401464 0.10324085529858 0.782118505849481 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDK18 -0.366454373038734 0.0914423443217519 0.47312329130067 -0.283210222566649 0.205407381131142 0.578666837313374 -0.106748096252248 0.82012363773682 -0.333673434431738 0.323907689725015 -0.440421530683987 0.218130060701352 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01474 0.683676225297617 0.0914425787769038 0.47312329130067 0.205739307910092 0.604971224923071 0.846449401489963 1.10702168543372 1.0 True False False False False False False 0 insufficient_or_context_specific +CHST1 -0.834833621302531 0.0915027681631722 0.47312329130067 -0.706187421672996 0.163643144047671 0.544850245278 1.07673094384452 0.108668572802626 -0.462959665818515 0.334960614090471 0.613771278026008 0.343362459988797 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPR39 -0.750274093726345 0.0915236597790219 0.47312329130067 -0.856344433063763 0.0501625045836679 0.405592093535716 0.380219725190377 0.464032707452759 2.0 1.64880202986073 0.0030100113083149 -0.975836288995176 0.0189155940866559 0.672965740865553 0.13264522111105 reversed False False False False False False False 0 insufficient_or_context_specific +SDF4 -0.470723666025484 0.0916459835740174 0.47312329130067 -0.388723004576734 0.17306815754655 0.554336007536445 0.500705774332287 1.0 -0.342179386388747 0.233710040860128 0.462763947220656 0.0769691119115789 0.120584560831909 0.669236271831733 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SART1 -0.305310593713934 0.0916824077046081 0.47312329130067 -0.483771594994968 0.0052042008113547 0.265121723850427 -0.366486263524526 0.16524889341361 -0.153889739552198 0.514163383397777 -0.520376003076725 0.0461611909183963 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM143 -0.41369789090794 0.0917513101913948 0.47312329130067 -0.369568053442158 0.137286900328172 0.523810858054217 0.7774154025448249 0.280582489250552 2.0 -0.257303479801402 0.517180233396694 -0.0473856868842062 0.899390109844151 -0.304689166685608 0.376570606856671 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDE9A -0.640168277304525 0.0918133182430588 0.47312329130067 -0.308099183390237 0.423981437409803 0.745302285457461 -1.83383614451391 0.0002588950166962 1.21683153357054 0.003145437360199 -0.617004610943375 0.0491584512209782 reversed False False False False False False False 0 insufficient_or_context_specific +C4ORF3 0.713526932645115 0.0918209318933845 0.47312329130067 0.823816065315811 0.0527096016702665 0.415925242477334 True False False False False False False 0 insufficient_or_context_specific +CDK5RAP2 -0.310004458448738 0.0918646265838697 0.47312329130067 -0.276343648423477 0.135853265856033 0.523136620282319 1.29399231850993 1.0 0.345969402201695 0.456251692377991 -0.175588948942972 0.638554742460503 0.170380453258723 0.703077273761247 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STAT6 0.230065670042522 0.0918725296853512 0.47312329130067 0.190698135323264 0.164369222068196 0.544850245278 0.505493039874416 0.589068089732006 0.0867618599123009 3.0 -0.0949607225017301 0.754402743944709 -0.107607372727835 0.652492829402231 -0.202568095229565 0.400734253037273 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRPS18C 0.697759841485896 0.0918887761851678 0.47312329130067 0.418383406758325 0.287198315615855 0.647499426921246 True False False False False False False 0 insufficient_or_context_specific +AL390728.6 -0.50535461876245 0.0918944441901908 0.47312329130067 -0.209555906259328 0.490147223323773 0.784761407373303 False False False False False False False 0 insufficient_or_context_specific +MN1 0.926870366860019 0.0919451854256883 0.47312329130067 0.961078297235275 0.0821611030367153 0.462431570888118 0.673206848493263 0.0551963748707658 2.0 -0.416312756513949 0.371076058725012 0.731567901011785 0.066901448774264 0.315255144497835 0.442967053498642 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AZGP1 -0.935477251758529 0.0920336821358479 0.47312329130067 -1.02455780957383 0.0625005123384967 0.432424907778406 -1.47020255701 0.0059210513872071 1.92928326860913 0.0017791022487874 0.459080711599128 0.279202534845817 reversed False False False False False False False 0 insufficient_or_context_specific +RABEPK -0.453486808861977 0.0920434969058133 0.47312329130067 -0.383085848277853 0.161456446034847 0.543541307772207 0.0972452396434611 1.0 0.222907729235091 0.660775688893002 -0.313029664408598 0.398710760099674 -0.0901219351735074 0.854536228766384 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYNJ2 -0.596036877004985 0.0923414967624838 0.474424098695038 -0.55052049415573 0.119695098151755 0.500502724013779 0.6756972292692961 1.0 0.482831882875943 0.105218771219594 -0.731876163596017 0.0144634721935699 -0.249044280720073 0.373596665418315 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DAG1 -0.454731516905794 0.0925641064451959 0.475145654053977 -0.141746076935933 0.622133660303529 0.854851430443277 1.00060198585178 1.0 0.223356734797616 0.560439397811325 0.261906840013047 0.399083671670811 0.485263574810663 0.141631600942261 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTRNR2L12 -0.868279183099029 0.0925825176487353 0.475145654053977 -0.895225219983698 0.0814214603156647 0.461068439742811 False False False False False False False 0 insufficient_or_context_specific +ADCK5 -0.627691065350564 0.0926178842421161 0.475145654053977 -0.467560155633581 0.229632400853973 0.601006169612357 0.943655559962277 0.309373868022212 2.0 -0.449366957379379 0.306557077244755 0.421304047375159 0.255181699377583 -0.0280629100042197 0.951105607161563 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STOX2 -0.539261010610681 0.092749131143086 0.475305143058798 -0.542984760216669 0.0903622841614825 0.47215517500088 1.78977507126098 1.0 -1.1339146602865 0.177622489787199 0.610792222922687 0.391419479997362 -0.523122437363817 0.477096550569562 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL139353.1 0.583050330503102 0.0927830933741412 0.475305143058798 0.330992250903261 0.339830456478294 0.687324315838944 True False False False False False False 0 insufficient_or_context_specific +NXF1 -0.519659293468694 0.0928793525939668 0.475567509547576 -0.476863745890075 0.12622122984676 0.508384607335028 0.471753036003647 0.442037159268005 2.0 -0.0232232271625668 0.948908860602002 -0.222634982309372 0.358442439635704 -0.245858209471939 0.333223392910515 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGAP10 0.729012564045375 0.09305942836392 0.476139327220794 -0.113956305443306 0.790248724349268 0.927375594093834 0.8340113697425291 1.0 0.309678476860592 0.399203551674546 -0.366918718436667 0.23386862216575 -0.0572402415760753 0.882160573064927 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GYG2 -0.718809520715362 0.0931216017751723 0.476139327220794 -0.710775360918043 0.0975460378755098 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +DHX30 -0.297594466200362 0.0931279773355396 0.476139327220794 -0.272714943005567 0.12507933026403 0.507527889672417 1.2590057247247 1.0 0.0580127881779929 0.870486660166867 -0.170565828010902 0.488140823567443 -0.112553039832909 0.692876775660894 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC034195.1 0.459473658969973 0.0932332879106986 0.476139327220794 0.621604117290998 0.023234735577699 0.346051520554005 True False False False False False False 0 insufficient_or_context_specific +AC092535.3 0.531392238853482 0.0933055986527343 0.476139327220794 0.51958684763225 0.102239240725693 0.479137456027696 0.0764755616844698 1.0 True False False False False False False 0 insufficient_or_context_specific +TRIM25 -0.405310271623931 0.0933529871775292 0.476145332666837 -0.395214125769616 0.102389919017776 0.479137456027696 -0.0954141498896636 0.740261315262556 -0.0186999403280619 0.941275391350961 -0.114114090217726 0.639653460919987 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MALRD1 0.515822191908159 0.0934826172009264 0.476576278323217 0.392205515361156 0.206037153307463 0.578776160707106 True False False False False False False 0 insufficient_or_context_specific +PVT1 0.689810425793308 0.0937128043532816 0.476750142624258 0.805702178715813 0.0490459724840684 0.404177169779245 0.319675766906216 0.414768318503824 0.317846770749837 3.0 True False False False False False False 0 insufficient_or_context_specific +ANTXR2 0.611132610917347 0.0937350868936846 0.476750142624258 0.4253383106354 0.254198348951849 0.619121653608424 0.125475387589703 1.0 -0.128124984466772 0.642598363767225 0.293669326183911 0.171844761012821 0.16554434171714 0.474989579145018 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SPPL2B -0.491215605789969 0.0937424982087478 0.476750142624258 -0.500407255928505 0.0877211882649411 0.468622105620855 0.130247361752322 0.666671539103799 -0.432938663663906 0.0736734941147535 -0.302691301911584 0.229611898048009 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC122 0.534888024193422 0.0938588983940781 0.477025002582352 0.283258776156313 0.384406991724822 0.719298323474503 -0.273870127439373 0.692046018169297 -0.283483519310913 0.595656234915717 -0.557353646750286 0.339889046972197 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PACRG -0.893740594115437 0.0938869061722038 0.477025002582352 -0.924554962736702 0.0827068426525483 0.463430311267398 False False False False False False False 0 insufficient_or_context_specific +CRMP1 0.689405191021086 0.0941335300792788 0.477507276304264 0.886535906436002 0.0350358570969434 0.37720666979567 True False False False False False False 0 insufficient_or_context_specific +FRMD4A -0.62043348766742 0.0942663169030679 0.477507276304264 -0.228286560849351 0.55046679167099 0.817186218568941 0.389725437635082 1.61090228323103 2.0 -0.364051947530164 0.364142502224753 0.425856889293167 0.211319512313292 0.0618049417630035 0.882553382780557 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC124947.1 0.597187375796875 0.0943078632962534 0.477507276304264 0.47486667895102 0.183924898393293 0.565716727964854 True False False False False False False 0 insufficient_or_context_specific +C16ORF45 -0.366768980236805 0.0943649332870746 0.477507276304264 -0.247123574775772 0.276036807303953 0.6396696093258 False False False False False False False 0 insufficient_or_context_specific +CSF1 -0.444649266375302 0.094366512358312 0.477507276304264 -0.401228202814125 0.137854577938302 0.523810858054217 0.3694653951091721 0.7086509237183879 2.0 0.0143006433403883 0.971220331487005 -0.377857771475879 0.171641458870372 -0.363557128135491 0.214154666453168 partial_or_other False False False False False False False 0 insufficient_or_context_specific +B4GALT4 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0.732309848268624 0.0949118380204351 0.479005346950169 1.01921077552542 0.0195289518730328 0.330467462546779 0.335264006779992 0.0255696222173155 2.0 True False False False False False False 0 insufficient_or_context_specific +PACS2 -0.291358709704055 0.0951104267692268 0.479258078302265 -0.312301054788017 0.0722954064115293 0.448733039913537 0.274734229913164 0.475432627002284 -0.645220132490024 0.0507824577073524 -0.37048590257686 0.287252836771288 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL117190.1 -0.782289409978566 0.0952536060887808 0.479258078302265 -0.785560901591707 0.0936904687294783 0.473775578029617 False False False False False False False 0 insufficient_or_context_specific +NDUFA5 0.441393112337331 0.0952942721445284 0.479258078302265 0.317175685845708 0.222506365035375 0.593397884800048 0.038429594528528 1.0 -0.0326552481817409 0.932558334579471 0.304083163853498 0.233417676516236 0.271427915671757 0.31448175068006 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PILRA -0.530549853099889 0.0953274374201211 0.479258078302265 -0.633457821940078 0.0426810334875235 0.391483132487066 0.85956823490546 0.465540783719518 -0.850801139848231 0.315274433519796 0.0087670950572284 0.995383082538173 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NDE1 -0.340467747765445 0.0954136419753286 0.479258078302265 -0.420500381426574 0.0315905844171084 0.375031405408838 0.2751921126367 1.0 0.429792029868108 0.148757698730074 -0.982703367663933 0.0040131829240319 -0.552911337795825 0.0627611720657026 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LMAN1 -0.352103465037525 0.0954244492773568 0.479258078302265 -0.0671680381219692 0.770501966709205 0.920631444062254 -0.39663808027387 0.213207196779859 0.115173955533053 0.698243579301301 -0.281464124740817 0.337867406261682 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIKFYVE 0.237571568168181 0.0955133160089956 0.479258078302265 0.189532235944776 0.195071552325538 0.571466550902615 -0.0243312337313941 0.956763050432602 -0.389764470035057 0.19402488000134 -0.414095703766451 0.205621141420143 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARFRP1 -0.601545055989432 0.0955457946877697 0.479258078302265 -0.633721567819948 0.078096990427736 0.457322349441485 -0.120904187297201 0.713799853236547 -0.310265922960021 0.222583639106703 -0.431170110257222 0.115519263343806 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIFC3 -0.492008352752901 0.0956274043675794 0.479258078302265 -0.4773106214086 0.105675242100879 0.483224012611202 -0.526583843436809 0.175144956637759 -0.631324116558376 0.078364821841147 -1.15790795999518 0.0099340070938692 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLEKHA6 -0.739933195133107 0.0956625887354203 0.479258078302265 -0.733028253717102 0.0992844237076744 0.478125555523304 1.05838444728868 1.1273250554899 2.0 0.0684114017400341 0.865841039320836 -0.241883840824705 0.398467316924564 -0.173472439084671 0.576121912698203 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM85B 0.398090198660228 0.0956994150533105 0.479258078302265 0.234018639868367 0.314784940755742 0.667014790741693 0.0967267556737166 0.136777112250908 2.0 True False False False False False False 0 insufficient_or_context_specific +AC015813.2 0.464479694443497 0.0957259185733917 0.479258078302265 0.57684621058472 0.0343745416029024 0.37720666979567 0.0135261256274219 1.0 True False False False False False False 0 insufficient_or_context_specific +CNNM4 -0.503947276060996 0.0957335941598293 0.479258078302265 -0.471090938774894 0.120722265715842 0.502003025375291 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0.665920588745846 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRFIP1 -0.420077792116429 0.096168053106582 0.480151093364473 -0.224609533590039 0.375895483363053 0.7132826228158 0.425282373746261 2.33048045502734 2.0 0.226964185504364 0.43489467448857 -0.455936200187286 0.072076198489853 -0.228972014682922 0.377622991129344 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC068533.4 -0.90059409969608 0.0962493207157563 0.480151093364473 -0.90260968311074 0.0957329616891672 0.47569521889622 False False False False False False False 0 insufficient_or_context_specific +DTNB -0.395955826995092 0.096387498888444 0.480151093364473 -0.30158827573445 0.208091804740908 0.580731946630546 -0.597939075977661 0.0502021717433179 0.211561408236566 0.414520184003729 -0.386377667741095 0.158832652591717 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SREBF2 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-0.372323448228052 0.205130934371804 0.0430523359458824 0.883708176953033 -0.32927111228217 0.224078614748809 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CENPV -0.765400038637587 0.0966993206037127 0.480151093364473 -1.07501036503857 0.0154440056260379 0.320853404849916 -0.178402127481527 0.660775688893002 0.30905420062235 0.299240838946481 0.130652073140823 0.714099039053588 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF630 0.573217486387837 0.096808469252922 0.480151093364473 0.63188996592941 0.0677166452589015 0.43786261079484 0.0475702555340554 1.0 True False False False False False False 0 insufficient_or_context_specific +SPOP -0.209374564018194 0.0968169441241791 0.480151093364473 -0.244650580690003 0.0480903957664915 0.402009816708327 0.350641758535484 1.0 -0.312969010453699 0.296302884083102 0.318757798165193 0.220285759389735 0.0057887877114939 0.986272547472679 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TPRKB 0.63833418052366 0.0968867082285284 0.480151093364473 0.17485537665355 0.647010643410927 0.868438643927354 -0.505480858597989 0.117172726940726 0.333876467190764 0.231779442114966 -0.171604391407224 0.575674716321094 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRKX 0.314450338882333 0.0969015918338135 0.480151093364473 0.210184607204688 0.263207541717554 0.626170623130675 -0.121666878817534 0.775302085709215 0.169691577662431 0.585106636376459 0.0480246988448971 0.901500715374742 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRE11 0.355647408889701 0.0969104557664396 0.480151093364473 0.0661371452037466 0.763886796609932 0.917095887442426 0.284763075500167 1.0 True False False False False False False 0 insufficient_or_context_specific +ANKRD11 -0.282731740476993 0.096944790680325 0.480151093364473 -0.323996023299583 0.0511550191948942 0.40964799201548 0.306232422346558 1.0 0.0118693774517475 0.968993547007747 -0.354026741751216 0.0973714437874117 -0.342157364299469 0.12452471071038 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COX15 0.584333771307776 0.0969513005323654 0.480151093364473 0.439949592432306 0.213476804466653 0.58619600202041 -0.0039262140096113 0.994351340251745 0.260073651674192 0.461848737129426 0.256147437664581 0.513601736488723 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CTNNA3 -0.690835874219578 0.097001458616983 0.480151093364473 -0.196483053404587 0.645189227677843 0.866765220234465 False False False False False False False 0 insufficient_or_context_specific +WDR6 -0.407186579188009 0.0970359028124862 0.480151093364473 -0.0911731655628194 0.731917757573701 0.904431845923655 0.328261888198917 0.325110457510834 2.0 0.341898449817417 0.301132840267642 -0.390561461349355 0.153011907518152 -0.0486630115319384 0.893102493173388 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF117 0.784719527991196 0.0970489139268597 0.480151093364473 1.01256867722825 0.0315399884007733 0.375031405408838 True False False False False False False 0 insufficient_or_context_specific +CMSS1 0.465107208299077 0.0971979177234769 0.480663051674225 0.56399131474289 0.0422407674503778 0.3908928278867 0.295378861764185 0.175284678907382 0.101394692428341 3.0 True False False False False False False 0 insufficient_or_context_specific +MYBBP1A -0.738784907739912 0.0973829858566935 0.480902509202512 -0.763488065305451 0.0860988705819698 0.467677448123587 -0.198360418314081 0.365219582006643 -0.406573879543565 0.0436718087936593 -0.604934297857646 0.0119205036902052 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM149B1 0.326084112969545 0.0975131765686284 0.481173538222432 0.127947305570381 0.52585462335548 0.804676662787375 0.56826737566037 1.0 True False False False False False False 0 insufficient_or_context_specific +AC003991.1 1.03665125918441 0.0975290179765111 0.481173538222432 0.220210026169322 0.722813574830959 0.901727431305591 True False False False False False False 0 insufficient_or_context_specific +NR1I3 -1.17542931123657 0.0977475371630558 0.481475707978739 -1.06411945117281 0.137395569679209 0.523810858054217 -1.48731547827613 0.0190409359930084 0.689631575393569 0.191190192383777 -0.797683902882557 0.141854943437561 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PGP -0.467300706564673 0.0978572871275314 0.481475707978739 -0.560745455547927 0.044222150097645 0.393650849907072 0.4766467438568079 1.0 -0.0994393905517629 0.789570833058506 0.0295367773175578 0.92629312930771 -0.0699026132342051 0.831187882684122 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZDBF2 0.409988989060406 0.0978590273753438 0.481475707978739 0.198550039345586 0.40770488514587 0.734313916303325 0.0395126043767177 1.0 True False False False False False False 0 insufficient_or_context_specific +NCAPH2 -0.901138233899531 0.0978638822999028 0.481475707978739 -0.799879310978461 0.147829526571928 0.53287270110837 0.217617309171574 0.448076653737742 -0.396605260435871 0.100217708194134 -0.178987951264297 0.492585102033106 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STK11 -0.418032925425504 0.0979251095450636 0.481552541488953 -0.469179728122548 0.0599238709213688 0.428473540531152 0.48159319907996 1.0 -0.144420027722621 0.642781738449557 -0.163993011109448 0.513956068330906 -0.308413038832068 0.233702098027981 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC011447.3 -0.445762212348024 0.0979907661139982 0.481651074781933 -0.415847165161916 0.123705463281372 0.505449799274277 False False False False False False False 0 insufficient_or_context_specific +LDB2 0.462824409236204 0.098071572203202 0.481823945705634 0.407912508438282 0.148206615490081 0.533506238950805 0.272593263375284 1.0 -1.09713650694322 0.0141442122680699 0.68987536032455 0.0667851648166951 -0.407261146618666 0.273858481503884 reversed True False False False False False False 0 cross_species_direction_conflict +ZNF500 -0.496566070788504 0.0981777846188948 0.481924608949589 -0.567711525116607 0.0513258430375343 0.41052897787143 0.264021954885909 1.0 False False False False False False False 0 insufficient_or_context_specific +AL590822.1 -0.790309841884014 0.0981938913443931 0.481924608949589 -0.702032852748329 0.149160219268098 0.533583468169136 False False False False False False False 0 insufficient_or_context_specific +SLC28A1 -1.00479855826656 0.0982289977703652 0.481924608949589 -0.88151859740558 0.150591368625356 0.533583468169136 0.334659101775932 0.577165307339192 2.0 False False False False False False False 0 insufficient_or_context_specific +USP6NL 0.394061184796412 0.0984085559653133 0.482357258069535 0.186929454437797 0.442214977885832 0.758062305003835 0.7537399667784259 0.0917591401428142 2.0 -0.136566834212091 0.738384439674932 -0.0121200389373076 0.973245500893908 -0.148686873149398 0.672128313056294 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SFXN5 -0.556303047681301 0.098642044631535 0.48327735833863 -0.670189548645982 0.0431888674467571 0.391724217341578 0.490607810754224 0.463983590507512 2.0 -1.03918342135081 0.0044084421107239 0.534094959117805 0.0630787677725422 -0.505088462233002 0.0847563536589539 reversed False False False False False False False 0 insufficient_or_context_specific +DCP2 0.372944618702044 0.0987345576751628 0.48350624301223 0.548986096683598 0.0127389178887596 0.313114831651016 0.0462270818164863 1.0 -0.133451134548295 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-0.454330187544275 0.535850100457866 -0.712845535106198 0.25037257366667 -1.16717572265047 0.092552405275499 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPINT2 0.604103956813966 0.0991916819504923 0.484365211599784 0.426748685323964 0.245150412653947 0.610669341516615 1.10743032116807 0.834312439932601 2.0 -0.149487624967766 0.644217953684941 0.0792963351758438 0.773698435551437 -0.0701912897919218 0.816536064181449 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CLDN14 -1.07559060594389 0.0991961698464128 0.484365211599784 -1.20032610911322 0.0623713097813777 0.431813959784778 0.7866336981103091 1.0 -0.635158898855754 0.353019164093726 0.068513890054863 0.919281653149987 -0.566645008800891 0.358596425160826 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DHODH -0.712086614100945 0.0992225625665114 0.484365211599784 -0.626358851938764 0.149729380926979 0.533583468169136 0.6076306015842979 1.0 0.196773652798962 0.546443183042633 -0.252144813631461 0.320622606726728 -0.055371160832499 0.86558148122306 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RCOR1 -0.287895993235323 0.0992310998948979 0.484365211599784 -0.139032023442542 0.434780494826434 0.75243712029294 0.349918185792975 0.136069358034473 -0.394127318483096 0.0622844818198569 -0.0442091326901213 0.859847049282305 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEC11A -0.368974057974131 0.0993491571473831 0.484549812292584 -0.256680700198093 0.264859284848587 0.627937081707572 -0.428454631270164 0.196752049273969 0.413445379568179 0.158795551729244 -0.0150092517019847 0.967567973182642 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HOXB-AS1 0.456540900275779 0.0994387934379297 0.484549812292584 0.422185867021708 0.131616516191033 0.517896578143491 0.532515894110713 0.29660584418415 2.0 True False False False False False False 0 insufficient_or_context_specific +MX2 0.66549974820987 0.0994715623223257 0.484549812292584 0.788769632123667 0.0499572860997471 0.40534943521819 0.741260960519609 0.0686983914508343 2.0 True False False False False False False 0 insufficient_or_context_specific +CSK -0.625102227415667 0.0994938821351182 0.484549812292584 -0.668962290248978 0.077127903146227 0.455668688469891 0.119407632059947 0.655332460123362 -0.130881267907739 0.537385612990621 -0.0114736358477921 0.965904321438031 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STK24 0.269592914627294 0.100020184903827 0.486389058212075 0.237257349822682 0.150014576919734 0.533583468169136 0.342559672893907 1.0 -0.116376331779537 0.706019276108263 0.0421984940003676 0.876797644043843 -0.0741778377791696 0.790801227508984 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GFRA1 -1.17600791839398 0.100080997683775 0.486389058212075 -1.08369881088656 0.130195355947827 0.515512442645691 -1.75119099299276 0.0018856555800233 1.20918218250499 0.0104333121129095 -0.542008810487775 0.180208177970548 reversed False False False False False False False 0 insufficient_or_context_specific +ARHGEF9 0.333178004053866 0.100143485532133 0.486389058212075 0.417158205203308 0.0352855619645267 0.37720666979567 0.0368270078933258 1.0 -0.462027700468925 0.657850240376196 -0.765757746379096 0.372276454994945 -1.22778544684802 0.194546743898624 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF678 0.494177366829932 0.100176980415981 0.486389058212075 0.363440649978625 0.231055814801719 0.601518427890281 0.733063718463981 1.0 True False False False False False False 0 insufficient_or_context_specific +ARMH3 -0.270200400451827 0.100228873691874 0.486389058212075 -0.165231782812725 0.325834782415557 0.675077178818285 -0.484278909090328 0.337480155379272 -0.142267648888168 0.756497375805644 -0.626546557978497 0.177904366749501 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTDP1 -0.451197703218674 0.100340879746413 0.486389058212075 -0.311411309487098 0.276213273763352 0.6396696093258 0.171457451169974 0.676910389914102 -0.414950373906303 0.18222920303154 -0.243492922736329 0.486984510686358 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MKL1 0.349560644997187 0.100350201051673 0.486389058212075 0.32743078363362 0.124955677492615 0.507221085339111 0.291625788392736 0.181712855321083 2.0 True False False False False False False 0 insufficient_or_context_specific +RHOC -0.564793401914874 0.100424413648911 0.486389058212075 -0.2772676984954 0.464102807382167 0.769834633203601 0.266991810980486 1.0 0.449543095559128 0.10471589033061 -0.305349588636448 0.200570237472373 0.14419350692268 0.590974300243057 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IBTK -0.312238002424971 0.100646158637331 0.486389058212075 -0.216939524681052 0.257756335658447 0.621906676979798 0.0178905707425171 0.964510570781438 0.0545123806911326 0.858857567871695 0.0724029514336496 0.824153930186941 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP2R2D -0.25204006798208 0.100652079887312 0.486389058212075 -0.302877660720106 0.0446494418584007 0.393650849907072 0.189820730834521 0.495465768719481 2.0 0.147980168122044 0.786774563585364 -0.0868914716598636 0.836543207084056 0.0610886964621808 0.903533812295188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBC1D20 0.325907629022191 0.100659224492649 0.486389058212075 0.159386946998444 0.428191830713687 0.74799415349718 -0.0002795238194278 0.99931014544354 0.338436575821245 0.157439247904815 0.338157052001817 0.190068439806477 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CXXC5 -0.535361991481948 0.10082447403831 0.48676184799889 -0.360059082394695 0.288114636909336 0.648258530618693 0.131949045269661 0.707183336473863 2.0 -0.276823236769943 0.515462044444265 0.115772061658063 0.756717508743207 -0.16105117511188 0.683169836203475 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CPPED1 -0.430598673005552 0.100828581319717 0.48676184799889 -0.459568077928484 0.0782372363587737 0.457322349441485 -0.206037715648278 0.654262114079441 -0.138801984862294 0.712528003505414 -0.344839700510572 0.368018867731255 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RIPOR1 -0.407988787604687 0.10102617299484 0.48727013909526 -0.318171258139119 0.217618923636144 0.589761880771731 0.418957428560674 0.151018737724519 -0.037673995131393 0.8958005122286 0.381283433429281 0.159087742195345 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYDE2 -0.66088177697914 0.101132142905501 0.487558522738025 -0.346360479861943 0.389718891143831 0.722218665388488 -0.32792161899818 0.451594467083153 0.307654764786667 0.373506207148748 -0.0202668542115128 0.964191832303003 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC018742.1 0.777900590763319 0.101305080617658 0.488073489121063 0.40256883395372 0.390777539591063 0.722309044643285 True False False False False False False 0 insufficient_or_context_specific +ZNF208 0.613437247806662 0.101405914579927 0.488073489121063 0.445814918483696 0.237890900630057 0.605329180588419 0.0537938122974959 1.0 True False False False False False False 0 insufficient_or_context_specific +AL592183.1 0.590213659949253 0.101470099320016 0.488073489121063 0.506769241573769 0.154925843371509 0.539282749619134 0.0506436249680531 1.0 True False False False False False False 0 insufficient_or_context_specific +SLC43A1 -0.493681534380171 0.101578162097822 0.488194981201462 -0.528808983972137 0.0770550446053334 0.455668688469891 0.307163030080619 1.0 0.602536947871094 0.181626715567711 -0.162198785136273 0.663038793380911 0.44033816273482 0.295260174361029 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC239809.3 0.525920493468708 0.101621509728937 0.488194981201462 0.542426239044855 0.0916967852595549 0.472460751419842 0.0417530225995616 1.0 True False False False False False False 0 insufficient_or_context_specific +ENO1 0.683001509218961 0.101650393701423 0.488194981201462 0.814143153365889 0.049534386341863 0.404880644205143 0.0543412117966485 1.0 True False False False False False False 0 insufficient_or_context_specific +AL391095.2 -0.798087265813004 0.101710624431523 0.488194981201462 -0.766283970229687 0.11795976190037 0.497635840420285 False False False False False False False 0 insufficient_or_context_specific +LRRC8B 0.700735562956294 0.101791113937047 0.488194981201462 0.522366314769251 0.229625530923424 0.601006169612357 0.147807551943651 0.303447955362303 2.0 True False False False False False False 0 insufficient_or_context_specific +AC097662.1 0.716550681130597 0.101909382046608 0.488194981201462 0.977675355204454 0.0243110035056923 0.349408136686844 0.0176598172652456 1.0 True False False False False False False 0 insufficient_or_context_specific +B3GLCT -0.398540097486222 0.101947928461262 0.488194981201462 -0.365877960333606 0.134443357267857 0.520900171021663 -0.385728915767188 0.571991546604707 0.259027318465624 0.626813595612162 -0.126701597301564 0.844250662838368 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF264 0.370211722698303 0.101958893153168 0.488194981201462 0.136553124851272 0.55081008249687 0.81739298747665 True False False False False False False 0 insufficient_or_context_specific +ATP2B2 -0.959411077817784 0.101997600594938 0.488194981201462 -1.05240380862533 0.0725716380317704 0.449108979935905 1.71281040661089 0.0629609329087514 -2.84188812304854 0.0054451042448924 -1.12907771643766 0.332646961763079 reversed False False False False False False False 0 insufficient_or_context_specific +RIOK3 0.328045994231656 0.102041160934813 0.488194981201462 0.125939272535701 0.52184083063522 0.802314792678957 0.0641846354435019 0.0946064284955723 2.0 -0.107283951303049 0.69747665351671 0.115627862085244 0.598962055218587 0.0083439107821956 0.975900275755031 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C16ORF95 -0.646475099127844 0.102050229542681 0.488194981201462 -0.377990076934102 0.343429806143565 0.690259260092091 False False False False False False False 0 insufficient_or_context_specific +PACRGL 0.28278116876182 0.102129765761138 0.488311932876063 0.290519552987165 0.0930628454706118 0.472709733823144 True False False False False False False 0 insufficient_or_context_specific +BCL3 -0.774698935332356 0.102320119998901 0.488311932876063 -0.5758512833503 0.230739967577287 0.601518427890281 0.377378968872931 1.0 -0.395097454046396 0.389498649467937 0.0650597106090067 0.884766756316662 -0.33003774343739 0.424185574979487 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DAZAP1 -0.357780234439551 0.102338903955691 0.488311932876063 -0.305075722990151 0.165916500435128 0.545545441169132 0.7179295316069592 1.0 0.080346782717307 0.868855565568195 -0.835930856933831 0.0274518894207396 -0.755584074216524 0.0485857999249041 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CSAD -0.352409972258262 0.102352179148961 0.488311932876063 -0.225815491178111 0.310843034491731 0.66386306487225 -1.10431252167178 0.0219060154685556 1.17536286220114 0.0128429519405663 0.0710503405293557 0.883659120843911 reversed False False False False False False False 0 insufficient_or_context_specific +EHBP1L1 -0.413575022067984 0.102621812817494 0.488987220408302 -0.445373247813238 0.0772497628056162 0.455668688469891 0.127317786524655 0.814413161254705 -1.29388268696998 0.008171363972995 -1.16656490044533 0.0183249855806438 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DIAPH2 0.454999238014847 0.102677842332172 0.488987220408302 0.460094171781423 0.0985345007585136 0.478125555523304 0.302060804826938 0.262721583658787 2.0 -0.339657703009759 0.246203106990261 -0.0041835215209069 0.989366444670661 -0.343841224530666 0.201594233875257 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ATL1 0.772298286149961 0.102875967965482 0.489345586515183 0.986930083450119 0.0371619413253 0.379484931484566 0.0345621916459008 1.0 -0.0031728983403906 0.996664352516797 -0.877073388015582 0.073035685932538 -0.880246286355973 0.100441257201587 partial_or_other True False False False False False False 0 cross_species_direction_conflict +F11 -0.893737446502528 0.102893275436987 0.489345586515183 -0.701330170624764 0.205431083779774 0.578666837313374 -0.889166502050249 0.0667885641616118 0.863385247705944 0.0501029797951973 -0.0257812543443058 0.959442154364209 reversed False False False False False False False 0 insufficient_or_context_specific +MAP6 -0.592725575982813 0.102963860220616 0.489460799734023 -0.575840786786033 0.114190867941414 0.4924007041452 False False False False False False False 0 insufficient_or_context_specific +NUDT2 0.689640864242146 0.103050306669412 0.489624770640425 0.380328619666577 0.363321192737623 0.704765682869143 0.0238327268781931 1.0 -0.112884574479527 0.845155842907057 0.771894417974652 0.0452528806176779 0.659009843495125 0.111010998081844 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CHN1 0.477914496648227 0.103091102967765 0.489624770640425 0.662317285492171 0.0227584432897514 0.346028040476539 True False False False False False False 0 insufficient_or_context_specific +C18ORF25 -0.292697372920433 0.103194528941771 0.489675432165043 -0.262123291398118 0.148129960999005 0.533506238950805 False False False False False False False 0 insufficient_or_context_specific +CCZ1B 0.395941202667586 0.103320942742257 0.489949366498203 0.0449130598364316 0.858469235062715 0.956914759994669 True False False False False False False 0 insufficient_or_context_specific +PAN3 0.271306202916483 0.103388782571047 0.489949366498203 0.23784294976554 0.153155486210093 0.536501533976828 -0.0539743601687716 0.885165796488022 -0.487383646042375 0.0699884985143911 -0.541358006211147 0.0609413484309298 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PABPC4 -0.551243868433977 0.103551273548676 0.490464203492951 -0.439652393217757 0.199795917197626 0.575263953748573 0.415887251762261 1.0 0.161280038988379 0.610370415266386 -0.392255327652978 0.12271122767577 -0.230975288664598 0.392670992040164 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP2R3C 0.293839484106898 0.103676762688283 0.490464203492951 0.184005090463076 0.32351547268048 0.673691919126913 -0.222113188860358 0.625040275548432 -0.613757154268007 0.0976512988814286 -0.835870343128365 0.0473736748509004 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF146 0.292566636180508 0.103748890208177 0.490464203492951 0.185858615086484 0.305478586303993 0.661588290091808 0.0735272790996124 1.0 True False False False False False False 0 insufficient_or_context_specific +C3ORF62 -0.448782209140453 0.103833324204991 0.490464203492951 -0.333614460974099 0.234170963413931 0.603018788225434 False False False False False False False 0 insufficient_or_context_specific +ATG3 0.456697677800593 0.103857900992478 0.490464203492951 0.554957174336497 0.0475878444902006 0.401835832584717 0.0217336852568618 1.0 -0.0394529350919114 0.912984811414039 0.352071948012077 0.144222495331125 0.312619012920165 0.218940449286614 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPSA 0.479278986194986 0.103943825383101 0.490464203492951 0.601740905622896 0.0423011559499789 0.3908928278867 0.355081331504527 1.0 True False False False False False False 0 insufficient_or_context_specific +LRRC6 -0.507415571411461 0.103960073673236 0.490464203492951 -0.284562432323424 0.371590835719683 0.710253546178141 False False False False False False False 0 insufficient_or_context_specific +RAE1 0.372763465319023 0.103967966208619 0.490464203492951 0.028225418662835 0.900574488747365 0.968057977213875 -0.0356725740441715 0.920161175417614 0.0065980966340252 0.981716426590568 -0.0290744774101462 0.922845826959116 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC027288.3 0.56395716588718 0.103975399707158 0.490464203492951 0.359869998305289 0.297168461957868 0.654889895570548 True False False False False False False 0 insufficient_or_context_specific +TTC38 -0.719092916862369 0.104171941460614 0.490464203492951 -0.845309827606095 0.0532509481040655 0.416631456505827 -0.163651955405458 0.730417369909899 0.670556959718651 0.0619458447238074 0.506905004313194 0.174898167856553 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CA5A -1.2262826297661 0.104171996289833 0.490464203492951 -1.23015899354859 0.103330030791466 0.47952541118609 False False False False False False False 0 insufficient_or_context_specific +JADE2 -0.38115155342306 0.104196932035868 0.490464203492951 -0.311039719265272 0.191148139060707 0.570403483290424 1.33664783391014 1.0 -0.921065089230807 0.0134992236524402 0.404820919897355 0.180495403142344 -0.516244169333452 0.105055145316442 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAF3IP2 0.374603200218484 0.104370899604658 0.490994708975628 0.292625610005472 0.218085057596744 0.590436230426177 0.205640122390691 0.513795013462938 0.0281693252631381 3.0 -0.615924727596019 0.0438496009947541 0.713518367448299 0.0160287499754662 0.0975936398522802 0.74035640136818 reversed True False False False False False False 0 cross_species_direction_conflict +METTL22 0.348233244162006 0.104419612236816 0.490994708975628 0.271045417157349 0.207479856563956 0.580525156990176 -0.249091949896212 0.634819778611299 -0.527104529197146 0.205240723211765 -0.776196479093359 0.0969327494239583 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC25A42 -0.676121262814885 0.104449149115293 0.490994708975628 -0.748763996507285 0.068350905388763 0.438244764077482 0.0366296947395344 1.0 -0.608388876510967 0.0855767475177688 0.338818349726124 0.270759094889009 -0.269570526784842 0.406024236672321 reversed False False False False False False False 0 insufficient_or_context_specific +SHROOM2 -0.710982468474341 0.104638498134355 0.491288094314487 -0.610917595329705 0.169020624868622 0.548585831083667 -0.381956152813105 0.269161575237314 0.427087968170639 0.148410477760691 0.0451318153575346 0.901731674491671 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PARVB -0.320734320247071 0.104689693105879 0.491288094314487 -0.27136235368772 0.177957198968032 0.560533900274534 -0.608119401594991 0.102513978234068 0.592176112067299 0.0654762968426826 -0.0159432895276921 0.96838315361203 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UPF3A -0.332679300334545 0.104697690112483 0.491288094314487 -0.498821390502383 0.0093589929774431 0.297984207800093 0.288237731449219 0.268302181913368 -0.376027254293287 0.0973714437874117 -0.087789522844068 0.737699879673548 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF3 -0.46076199065602 0.104767530233689 0.491361175610986 -0.543489606220525 0.0487739038257306 0.404047580308211 False False False False False False False 0 insufficient_or_context_specific +A1CF -0.948365020453142 0.104806342818331 0.491361175610986 -0.890844426434155 0.128679695764462 0.512298783498625 -1.02554858643717 0.0513705956497171 1.00495409023785 0.0393536309413555 -0.0205944961993181 0.971277478566388 reversed False False False False False False False 0 insufficient_or_context_specific +AC073569.2 0.560625663869826 0.104874987838583 0.491464767687422 0.268789422670216 0.449312416701328 0.763657516988509 True False False False False False False 0 insufficient_or_context_specific +SNX8 -0.591464323487275 0.104981512764415 0.491745701759847 -0.626836551433455 0.0830772151431423 0.464581163920178 0.599520866190031 1.0 0.267878679114975 0.270122622191373 -0.528192291320017 0.0234257198855671 -0.260313612205042 0.247437087811161 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLIPR1 0.821511993695441 0.105192799823401 0.491938900073281 0.513588242851136 0.319827155805993 0.672254650806227 True False False False False False False 0 insufficient_or_context_specific +AC010809.2 -0.791734678414983 0.105200210909128 0.491938900073281 -0.271053065701265 0.601738170574956 0.844272638528955 False False False False False False False 0 insufficient_or_context_specific +DCP1B 0.379452852550989 0.105218381180965 0.491938900073281 0.170669628195403 0.461539394029736 0.769126302007068 -0.422228991057069 0.37679897285318 -0.489856291993155 0.233185712458966 -0.912085283050224 0.0504747545196111 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAMDC4 -0.885640120462327 0.105260583743533 0.491938900073281 -0.831075920418564 0.133210684954036 0.51936425839908 False False False False False False False 0 insufficient_or_context_specific +CABIN1 -0.279579681407157 0.105562833336374 0.492472901849632 -0.142348603406175 0.412113120025253 0.735291083225579 0.117600298430899 0.7188507548735 0.17630812222488 0.477545063263485 0.293908420655779 0.26552257421949 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A6 0.579294822863936 0.105582501598265 0.492472901849632 0.42742433843941 0.237934845561843 0.605329180588419 True False False False False False False 0 insufficient_or_context_specific +CAMK2G -0.471964208681726 0.105997773885407 0.493371715750834 -0.254351035943476 0.388114571167424 0.721576369618013 0.9046500882471159 1.0 0.0426617455134662 0.931049044353546 -0.449498759771793 0.169519650175477 -0.406837014258327 0.249077815077982 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYBRD1 0.543461041941647 0.106141607306182 0.493457987643623 0.607081340080029 0.0704564572882377 0.443089546602487 1.37606932370925 0.10115619289266 0.132594274606428 3.0 -0.325862873499996 0.841745367226284 1.46415993306283 0.106162430097961 1.13829705956283 0.266470793772336 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DHX16 -0.39262028258374 0.106280242878908 0.493885037110699 -0.506019308839951 0.0342018267572393 0.376543096535729 -0.18657992260727 0.49492500911357 -0.0119043454015336 0.964162706928666 -0.198484268008804 0.406626709410067 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNPC3 0.282538016202562 0.106498915553438 0.494520186619343 0.256144638032625 0.144205845806265 0.531456702445067 0.0875292173297444 1.0 -0.213802022936345 0.558934510467113 0.318677239987532 0.267716262329914 0.104875217051187 0.758151431384777 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PA2G4 -0.66752956633103 0.106535875819093 0.494520186619343 -0.6601528315877 0.111493030927295 0.489864095102115 0.090100715007891 0.863533101705804 0.45818273840877 0.182960740132842 0.548283453416661 0.151403924767697 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SUDS3 0.260125263994385 0.106583310323018 0.494520186619343 0.282544863792919 0.080505749386668 0.460444042266761 1.61111497923808 1.0 -0.549225477479546 0.0794196334667497 0.454914225669328 0.102988915954324 -0.094311251810218 0.765550611673659 reversed True False False False False False False 0 cross_species_direction_conflict +SH3GL1 -0.417611460737873 0.106671804771608 0.494520186619343 -0.28679957785327 0.280815519706738 0.642821222582925 0.7188296285571121 0.342788735124595 2.0 -0.0407564047546552 0.901577906130256 -0.289540005463469 0.199313232410924 -0.330296410218124 0.166576239234014 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KYAT3 0.432390057136757 0.106697952748519 0.494520186619343 -0.0086004240402113 0.973992329133714 0.992450915625761 -0.118083924469747 0.856375858040323 0.24027704642024 0.608652883867055 0.122193121950493 0.82071832347107 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPRC1 -0.554761114700792 0.106866632534622 0.495084645151621 -0.426375004022252 0.228117375275012 0.600314867436086 0.4817603394239799 0.515970982336503 2.0 0.149157566207009 0.685678336076267 -0.92692605658109 0.0081642758795006 -0.777768490374081 0.0268452843137404 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WIPF1 0.393406451334966 0.106967094234188 0.495293688960813 0.601315520515499 0.0114612565133173 0.303576144732418 0.519742030410814 0.105457643503522 2.0 -0.177671276731258 0.617195227329208 0.219061930617198 0.435002331284472 0.0413906538859403 0.905903214090264 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC091948.1 0.583464676056988 0.107005579136164 0.495293688960813 0.360758086843195 0.318340952628841 0.670352618945772 0.0360860702610145 1.0 True False False False False False False 0 insufficient_or_context_specific +LINC01505 0.576679506732317 0.107092362362297 0.495410922437732 0.629237194141359 0.0793103788739789 0.459078388240937 0.4838470373407079 0.0607719426378437 2.0 True False False False False False False 0 insufficient_or_context_specific +DCAF6 0.268875159870475 0.107124752408159 0.495410922437732 0.310967410268901 0.0576578877622196 0.424809475920108 0.274567699656398 1.0 -0.187295765185043 0.574349806730863 -0.0112622036694661 0.971447894886009 -0.198557968854509 0.492405341885104 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KLF13 -0.663941555404498 0.107310133806094 0.495746611144434 -0.794176592631387 0.0487554548606723 0.404047580308211 0.297203564497195 1.41060568272143 2.0 -0.53613154721195 0.0943550409468221 0.675126183047439 0.0273407528137498 0.138994635835489 0.654005505924585 reversed False False False False False False False 0 insufficient_or_context_specific +RCSD1 -0.481136142313462 0.107347329838445 0.495746611144434 -0.335482181125317 0.283584187732796 0.644442930280426 -0.0212690223597432 0.957440974715565 0.263922529115859 0.330327995439636 0.242653506756115 0.396293703072063 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PGF -0.546658991378822 0.107479067333738 0.495746611144434 -0.423180767634145 0.227508180082636 0.599715891655649 False False False False False False False 0 insufficient_or_context_specific +HSPBP1 -0.596872018565293 0.107623690098959 0.495900555302245 -0.504941831481674 0.18107047851972 0.563603217043398 1.29381155001922 1.0 -0.188338974463259 0.673892943675193 0.408505577937257 0.223676882843322 0.220166603473998 0.557105446068158 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM38A -0.544621857000272 0.107628636898882 0.495900555302245 -0.495471640831416 0.14767372941715 0.532846198833773 0.35227388967015 0.433032626325651 -0.456521618046775 0.202952858361817 -0.104247728376625 0.820746829632542 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SH2B3 -0.441965129958906 0.107708460705342 0.495938041049716 -0.346688455149916 0.220014688378146 0.59217704709374 -0.114621561778895 0.715407116185129 0.0438173754278888 0.873950070019486 -0.070804186351006 0.803575426309461 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL4 0.50093976927697 0.107830672028175 0.496284322263938 0.500032470767205 0.108426396849576 0.485070295736365 True False False False False False False 0 insufficient_or_context_specific +KANSL2 -0.449834995113106 0.108059824900949 0.496920590389332 -0.303173404703487 0.282820202882368 0.643954216526212 0.238013721033447 0.339773283392283 -0.741315716307641 0.005936567007941 -0.503301995274194 0.0406996068448224 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFATC2 -1.4553692962722 0.108063049397036 0.496920590389332 -1.51274840843834 0.0954191051313186 0.475429406312629 1.26340016729951 0.9782629518723629 2.0 False False False False False False False 0 insufficient_or_context_specific +SLC2A2 -0.757268840264191 0.108447390268533 0.498160679812136 -0.686678399794507 0.148085014071211 0.533506238950805 -0.101515625045098 0.85968155287448 0.635857960049564 0.116217059553866 0.534342335004466 0.204183570911617 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRP5 -0.526286345155185 0.108544657390334 0.498160679812136 -0.818832521377828 0.0094870583237627 0.298763048903795 -0.201931182977908 0.525907880106439 0.1906814524922 0.470538240581751 -0.0112497304857072 0.973340448497963 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIER1 0.302938159646638 0.108563672164024 0.498160679812136 0.218110355526591 0.250290753084322 0.616672648883528 0.0694609863373061 1.0 -0.0980808969452807 0.724047025634471 -0.0993918560770352 0.655536878818856 -0.197472753022316 0.381035600302654 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MR1 0.426754975738425 0.108596446833539 0.498160679812136 0.119801139518081 0.643580863336885 0.865926692380634 True False False False False False False 0 insufficient_or_context_specific +NES -0.773930297204374 0.108615825433561 0.498160679812136 -0.584303375227252 0.23678297052538 0.605329180588419 0.5079733029154191 1.0 1.32045427216358 0.0082935207369948 -1.51404588737633 0.0033471189363927 -0.193591615212753 0.676180017484306 reversed False False False False False False False 0 insufficient_or_context_specific +CDC42EP1 -0.56918267511315 0.108761390540144 0.498611707044219 -0.494979527014885 0.171194588709854 0.552068560659328 0.175744345371676 0.259780531265819 2.0 -0.351495840533189 0.276545270916531 0.521332218007305 0.0749194721102918 0.169836377474116 0.580208140143787 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FGFR1 -0.459116729602785 0.108819006079323 0.498659316920788 -0.486442556634182 0.0866678568038857 0.467809285536833 0.576865906194787 1.0 -0.477167716823439 0.0619502093147305 -0.275562840658099 0.215576697141295 -0.752730557481537 0.0093579283120773 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMED4 -0.441317345811529 0.108922185308473 0.498915588931392 -0.201144343221651 0.46103383537874 0.768850929383785 0.332919538200327 0.546408487125454 2.0 -0.392877756784006 0.155847155576129 0.280114745405201 0.246272443378976 -0.112763011378806 0.679982814546517 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALAD -0.486724801981779 0.109099143137277 0.499509433323231 -0.280583761058478 0.361001413485033 0.703177809506737 0.428654189372064 1.0 -0.18983791745141 0.632794736022143 0.0289785267817271 0.937929784560058 -0.160859390669683 0.648693716009035 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KANK1 -0.430977658523486 0.10916910886522 0.499593271874792 -0.270358320199985 0.323076908767548 0.673321358619774 0.37753414587814 1.0 -0.211240118226873 0.520860017236944 0.077535040308146 0.787897364742952 -0.133705077918727 0.65913666943703 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC02499 -0.968707171564497 0.109212092393163 0.499593271874792 -0.985520546148899 0.10287171081695 0.479239170340314 False False False False False False False 0 insufficient_or_context_specific +ZNF706 0.345070071843991 0.109338882315569 0.499946459576145 0.521108909924496 0.0104607772110337 0.302245517751671 0.0463932741408578 1.0 True False False False False False False 0 insufficient_or_context_specific +NLN -0.494343931743992 0.109384004699839 0.499946459576145 -0.09026404445191 0.780213421363037 0.923692902304434 0.0838845041694148 0.859070568791721 0.0956676672499439 0.775469869289175 0.179552171419359 0.622468534454023 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP5F1E 0.48541869176558 0.109558873232688 0.500271205737744 0.672827450322322 0.0242970280043138 0.349408136686844 True False False False False False False 0 insufficient_or_context_specific +ENTPD6 -0.574594557232329 0.109615722252356 0.500271205737744 -0.502914982848335 0.166582000406386 0.546847691536137 0.158146777104173 0.815171844574446 -0.126644802327079 0.791911932576524 0.0315019747770947 0.958652543348352 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TERF1 0.343290712785908 0.109630524515359 0.500271205737744 0.277538869400334 0.193267745922981 0.570885363891703 -0.217936059192937 0.583620487806782 -0.378514717339694 0.23407049416852 -0.596450776532631 0.0898530637373285 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAP2K7 -0.39146528874469 0.109691972085895 0.500271205737744 -0.504393444905187 0.033437801751613 0.376280667109215 0.763381387182217 0.368717561622442 2.0 -0.291289366514494 0.303350793900669 -0.390229068640963 0.118448125464285 -0.681518435155457 0.0215938894057004 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STRADB 0.412189826291064 0.109862367879645 0.50036681364622 -0.0754274946623507 0.757512817079039 0.914454644719928 0.257654680748093 1.0 -0.164854409182304 0.658153866993328 0.286879890929589 0.30205042457518 0.122025481747284 0.70994130180562 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KATNA1 -0.342645176068769 0.109968532306265 0.50036681364622 -0.11888164960625 0.618896036071761 0.853557418006095 0.112962721920982 0.770168103325682 -0.318884738247539 0.250709580059907 -0.205922016326557 0.51678434334942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GGNBP2 -0.266697100371837 0.109995349611085 0.50036681364622 -0.136468565305202 0.439382178867428 0.756276009860174 0.339688011234499 1.0 -0.256893991172169 0.241389633926465 -0.0911411914123502 0.64929371433885 -0.348035182584519 0.092933097315602 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ENOX2 0.248679076723882 0.110088140797876 0.50036681364622 0.243918523753191 0.116215000087211 0.494557827860048 -0.133518697677944 0.81927836022074 0.340478882617499 0.381989561295581 0.206960184939555 0.654166388964995 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TM4SF4 -1.01383455335699 0.110094493379579 0.50036681364622 -1.04832627650866 0.0987603437329772 0.478125555523304 0.402787359629214 0.410716033843546 2.0 0.785277841116553 0.153500658649711 -0.425724416074343 0.377291093572135 0.35955342504221 0.486096272272659 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABHD6 -0.488657417642319 0.110142130772859 0.50036681364622 -0.387094268985246 0.214943267036139 0.587852789707652 -0.418493713333099 0.392184756924999 0.484823906433971 0.226634176013186 0.0663301931008723 0.895311082948626 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TECPR2 -0.264107127987843 0.11025872402362 0.50036681364622 -0.177319309880442 0.292888312808498 0.651509781962399 -0.0409019277675843 0.928457635800105 -0.0266485131231239 0.938168709893813 -0.0675504408907083 0.853429655348404 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFHX4 0.385736326850515 0.110272647076072 0.50036681364622 0.183888586718396 0.462073132565906 0.769126302007068 -1.09774130828531 0.0139904692070938 0.920158212186256 0.0207351865170919 -0.17758309609905 0.646581243220367 reversed True False False False False False False 0 cross_species_direction_conflict +STAT5A 0.487835619271177 0.110339897428297 0.50036681364622 0.158613294327805 0.618968536849101 0.853557418006095 0.473812789544446 1.0 -0.449064644464055 0.185091270678526 -0.071332608799687 0.824128162040477 -0.520397253263742 0.104107005390769 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC25A38 -0.530437548751171 0.110342850720017 0.50036681364622 -0.349755153847767 0.317164689678879 0.669290253214092 -0.50618478042278 0.181263698830266 -0.168314947772707 0.623775275497813 -0.674499728195486 0.0670324052500536 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MDS2 -0.882383797423228 0.110370248455688 0.50036681364622 -0.837960374111364 0.131371123165125 0.517896578143491 False False False False False False False 0 insufficient_or_context_specific +AC008629.1 0.753186117042377 0.110381120249465 0.50036681364622 0.648150002410762 0.165493974931493 0.545468009482397 True False False False False False False 0 insufficient_or_context_specific +MSH6 -0.269361167510506 0.110390813191169 0.50036681364622 -0.230198198783821 0.17683151428052 0.558978181968183 1.44754803889322 1.0 0.375621314824115 0.384166755508118 -0.168653375426025 0.631046471138302 0.20696793939809 0.615018824537977 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WWC3 -0.290576270271733 0.110493590179292 0.50036681364622 -0.34913203986604 0.0507849486220309 0.408254884487698 0.362023211733279 1.0 False False False False False False False 0 insufficient_or_context_specific +USF2 -0.377186945318222 0.110518602900453 0.50036681364622 -0.527182029691985 0.0190488276748401 0.330467462546779 0.67688324949596 1.0 -0.409749271327955 0.147085813244359 -0.28474520483756 0.253041195547586 -0.694494476165515 0.0206212459289334 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IL6R -1.1453288544109 0.1107490340578 0.501195157129124 -1.23942353819893 0.0827397363836944 0.463430311267398 False False False False False False False 0 insufficient_or_context_specific +PILRB -0.317591951364035 0.110906678422723 0.501563945445592 -0.273763339541413 0.166962444331297 0.547438895086435 False False False False False False False 0 insufficient_or_context_specific +ZNF782 0.322666758012845 0.111032523534155 0.501587325415229 0.246072368792713 0.228932222995744 0.600424738880655 1.09469182541838 0.0735904537488352 0.0520210161876156 3.0 True False False False False False False 0 insufficient_or_context_specific +DYNLT1 0.606953278371641 0.111120738221843 0.501587325415229 0.319773426290096 0.401571390389784 0.730970076414215 True False False False False False False 0 insufficient_or_context_specific +RNF213 -0.313245610164449 0.111260565042737 0.501737698716141 -0.270144148864862 0.173128099998276 0.554336007536445 0.419905320712101 0.236644723150733 -0.389624223279276 0.208817388820099 0.0302810974328246 0.937284010331148 partial_or_other False False False False False False False 0 insufficient_or_context_specific +JOSD1 0.415438069366476 0.111430315042318 0.502024697887383 0.366120876562065 0.160066475754836 0.543541307772207 -0.0752924546099255 0.878121975370437 0.111993190371935 0.753618139547397 0.0367007357620094 0.929848883257229 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRAPPC12 -0.237278230031024 0.111455379034668 0.502024697887383 -0.207351694882705 0.16581988481892 0.545468009482397 0.248915533758585 0.35503656628964 0.145232436280919 0.522353528565771 0.394147970039504 0.109928988695551 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADRM1 -0.687880578979984 0.111550192041277 0.502237495766228 -0.420987545277224 0.348247235024793 0.693734774979578 0.373210022435059 1.0 -0.557536795535803 0.0863826925477337 0.704727570640053 0.0216096866197318 0.147190775104249 0.632767137242387 reversed False False False False False False False 0 insufficient_or_context_specific +LMO7-AS1 1.09190207472202 0.111785385103931 0.502867531285602 1.29293801494751 0.0610101794307113 0.429268745755419 0.5335954240738731 0.819366208457585 0.0869571479223518 3.0 True False False False False False False 0 insufficient_or_context_specific +TENM2 -1.03093578647974 0.111925197141723 0.503067786897534 -1.22344242659906 0.0551018691319876 0.420654760878905 False False False False False False False 0 insufficient_or_context_specific +AC105402.3 -1.64360895309404 0.112044333506143 0.503322725052621 -1.69123074963205 0.101219927868601 0.478335084675213 False False False False False False False 0 insufficient_or_context_specific +TMEM37 -0.869498983884119 0.112116170632478 0.503322725052621 -0.896224006791704 0.100546983977458 0.478125555523304 -0.562010262119663 0.31738191177615 0.472068070493346 0.324736336718888 -0.0899421916263171 0.87846803337313 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CWC22 0.41926023728164 0.112165409682563 0.503322725052621 0.431862830326501 0.101675087181665 0.478843828869436 -0.401048213916355 0.12655605970275 -0.454919830975669 0.0616215833826196 -0.855968044892024 0.0068388228821503 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARVCF -0.723429289652462 0.112172605801176 0.503322725052621 -0.66572814274973 0.146979934604794 0.532796338690088 -0.666445937600717 0.121476060047674 0.38876883267941 0.305086987284974 -0.277677104921307 0.490123065276328 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIF21A -0.298034988817765 0.112437687256358 0.503657147489441 -0.1260344414729 0.498354586765531 0.789678482225796 -0.957094608864173 0.0167739154051855 1.22919187575589 0.0035867911549677 0.272097266891718 0.406364935851257 reversed False False False False False False False 0 insufficient_or_context_specific +TNIK 0.456118709597135 0.112437951944745 0.503657147489441 0.529671523419932 0.0595105375829954 0.428473540531152 0.4317554511977439 0.157316876340466 0.112570524897579 3.0 -0.0493593044986307 0.941363125049339 -0.39882143340547 0.365735717847491 -0.448180737904101 0.364972095284236 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KANSL3 0.209148571488734 0.112582225142091 0.503960043490755 0.267655239106006 0.0400775320066415 0.382930844277032 0.503775087874801 0.6547273911096899 2.0 -0.0174286619279853 0.95834264814358 -0.534738615905048 0.0336970967553493 -0.552167277833033 0.0376359792317375 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TIRAP -0.604345532805406 0.112648311733317 0.503960043490755 -0.724668204897609 0.0542818652831954 0.419106270466538 -0.460917867566652 0.192421543730535 -0.0115346992236065 0.974384024109416 -0.472452566790258 0.151417431212278 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ISYNA1 -0.475503852049808 0.112753029902142 0.504091784672136 -0.117418256847819 0.69367587969111 0.887197427964856 0.372821320337207 1.06435804569447 2.0 0.204949617777969 0.719214521019672 -1.30542274311148 0.013141788530269 -1.10047312533351 0.0335609359811547 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SASH1 -0.368699002724352 0.112773706705397 0.504091784672136 0.0208812955754768 0.927018917413831 0.979087152943213 1.65272553052151 1.0 0.0900173004644348 0.769371208284727 0.299464371660003 0.190002666945131 0.389481672124438 0.111553482731439 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC124312.1 0.289742723485195 0.113063490928396 0.504881416452792 0.180715931824155 0.319390127572306 0.671871083265273 True False False False False False False 0 insufficient_or_context_specific +SHMT2 -0.507318357222954 0.113093819843801 0.504881416452792 -0.425236410044818 0.188334368405883 0.56929178900529 0.4823411123754871 1.0 -0.472994891062309 0.244345138176277 0.433520291554291 0.223303040126558 -0.0394745995080184 0.927837341033715 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAF4 -0.787849753900494 0.113215410814306 0.50499717252955 -0.505873907555141 0.331580986950651 0.680373309040058 0.285288356817004 0.416984035146931 -0.235507212993148 0.415003520348001 0.0497811438238567 0.893102493173388 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IGF2BP2 0.510143262393733 0.113485898214725 0.505495336947715 0.536767872100612 0.0966666048179496 0.477364833333916 0.338850271799898 0.0696527539061183 0.109241062185005 3.0 -0.223681516269426 0.760551622069903 -0.804984452653759 0.154864694350096 -1.02866596892318 0.106670125107661 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC003002.2 0.539719634756614 0.113562288917037 0.505495336947715 0.621125354825229 0.0694432177523693 0.441118118691429 True False False False False False False 0 insufficient_or_context_specific +DUSP5 0.841102006398445 0.113604188375972 0.505495336947715 0.804392762972691 0.13304799515424 0.519212049578983 1.48437449285619 1.35091189605783 2.0 -0.531214783584214 0.30720458716372 -0.286092285743718 0.534688835450744 -0.817307069327932 0.0955152398689109 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EPS15 0.257433799659689 0.113685730472462 0.505495336947715 0.177302875324526 0.279531942184365 0.642114507827558 -0.346074595640973 0.145618043828569 0.122771985839233 0.562092981692175 -0.22330260980174 0.307797156598588 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPS11 0.413536901758757 0.11380410900106 0.505495336947715 0.416965147910702 0.111141777197987 0.488819418659101 True False False False False False False 0 insufficient_or_context_specific +SH3RF2 -1.33845552564108 0.113807002203885 0.505495336947715 -1.65285628759627 0.0447358822228731 0.393650849907072 -1.19047395325639 0.046574573711829 0.337025504570676 0.518806625741531 -0.853448448685713 0.10646397681699 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SSR4 -0.923453054478397 0.113844050645603 0.505495336947715 -0.699501850434069 0.244774803263412 0.610669341516615 0.008605088000145759 1.0 -0.339470262957941 0.317934656023734 0.493507030576349 0.098929251676969 0.154036767618408 0.635434805045057 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIF16B -0.327511476473825 0.113873303054691 0.505495336947715 -0.250468834381077 0.231158080255059 0.601518427890281 -0.311119009162916 0.394037389863102 0.284221739675664 0.34342356809709 -0.0268972694872527 0.942736837147951 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GREM2 -0.953592988438461 0.113893050420244 0.505495336947715 -1.04511743348017 0.0824093204763228 0.462431570888118 -2.86962573897281 0.003485319640606 2.3954852064395 0.0068255517655478 -0.474140532533316 0.424097135121227 reversed False False False False False False False 0 insufficient_or_context_specific +PRPF3 -0.261111857268266 0.113931262592179 0.505495336947715 -0.265846935632579 0.105687804467846 0.483224012611202 0.628669939583634 1.0 -0.137713052089226 0.675926385250434 -0.910865252944328 0.0056542642085908 -1.04857830503355 0.0047632475324113 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANOS1 1.13382084976105 0.113970758497436 0.505495336947715 0.0281813893882436 0.966527225480297 0.990805143378026 True False False False False False False 0 insufficient_or_context_specific +COPG1 -0.320005309301005 0.113997385610202 0.505495336947715 -0.142399506966627 0.493867194658523 0.786363265568912 -0.0612835330337703 0.8481150306154 0.146764476912848 0.516323565229439 0.0854809438790777 0.739564849239821 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP4F3 -1.08105917302167 0.114183412901925 0.506018923663156 -1.12762367644239 0.0988864547905293 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +SH2D3C 0.751742121986619 0.114392998487409 0.506398858712816 0.632617799976747 0.183351879250108 0.565541146173142 0.525539835294524 1.0 -0.318388944748024 0.325989844005511 0.210568533980883 0.447867652136222 -0.107820410767141 0.735118690426927 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GNPTG -0.420411250197531 0.114593292691461 0.506860487740448 -0.498486945172756 0.0605285037676427 0.429268745755419 -0.561015443739464 0.0345441401772278 0.607583565539183 0.0166606814192818 0.0465681217997182 0.862073966435473 reversed False False False False False False False 0 insufficient_or_context_specific +ACTL6A -0.376056192055715 0.11474467433772 0.507317534194993 -0.371134675259758 0.119684174582303 0.500502724013779 -0.0901502352610476 0.823671125827196 0.159184541766814 0.577658775874375 0.0690343065057662 0.841222559462295 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBFD1 -0.45410596570552 0.11479683364314 0.507335692592829 -0.484949027687023 0.0896038549485026 0.470746198832535 -0.282609336937128 0.29823132957759 0.190692590147214 0.414520184003729 -0.0919167467899137 0.732051959658599 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GDF11 -0.611906009435957 0.114996082853973 0.507484271612428 -0.553877906294974 0.156164897233196 0.539558215777 False False False False False False False 0 insufficient_or_context_specific +COL25A1 -1.15681728619056 0.115017772225938 0.507484271612428 -0.321999190906555 0.661364584158345 0.87272681909059 False False False False False False False 0 insufficient_or_context_specific +PLXNB2 -0.397106365716596 0.115080009966298 0.507484271612428 -0.367836935013472 0.147314699926078 0.532796338690088 0.0965611979009521 0.763870119856501 0.17861321145833 0.460468052287564 0.275174409359282 0.276273685316835 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NIPAL2 0.409155275152257 0.115089002717426 0.507484271612428 0.351240480070339 0.176502622304106 0.558469004245985 0.7453082295388679 0.09017905671391399 2.0 True False False False False False False 0 insufficient_or_context_specific +UBA5 0.352870102184624 0.115122732858075 0.507484271612428 0.447188558951835 0.0464413533709037 0.398741839274603 0.448522916487351 0.0519315182489266 2.0 -0.0527153609184837 0.873757657853394 -0.491305194787779 0.0471500981270426 -0.544020555706262 0.0403429395905604 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CCDC93 0.29846957690652 0.115214983808959 0.507484271612428 0.254050338222976 0.182601601819089 0.56470641827942 -0.192760010022665 0.594981934558781 -0.208707925440894 0.471966310167054 -0.401467935463559 0.194093119192605 partial_or_other True False False False False False False 0 cross_species_direction_conflict +YTHDF2 -0.325017682835741 0.115496172141634 0.507588519560785 -0.184522548340322 0.390281054292911 0.722218665388488 0.435781063852387 0.713799853236547 0.23371251624503 0.768647447722691 0.669493580097416 0.483702587898667 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TEPSIN -0.583894939634322 0.115538524175808 0.507588519560785 -0.542361788677039 0.146435555991285 0.532796338690088 0.6127380474182299 1.0 0.157920144437078 0.612088060974856 -0.647483924408392 0.019717062778194 -0.489563779971314 0.0796964443580893 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXW7 0.226688137061843 0.115547127370284 0.507588519560785 0.225534493529198 0.116183193070879 0.494557827860048 1.16584531850086 1.0 -0.219702720552111 0.499773360451384 0.0053148833624441 0.986951802046782 -0.214387837189667 0.452970231852519 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RUFY3 0.260938958985657 0.115620418942939 0.507588519560785 0.368187503876518 0.0196782297544084 0.330467462546779 0.113822140213902 0.0830007089542774 2.0 -0.302289040051224 0.337730132501224 -0.420560457307279 0.128732653862785 -0.722849497358503 0.0257986126069065 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NAA60 -0.520915780776358 0.115623260991067 0.507588519560785 -0.382898330224203 0.253136592847895 0.618991529980024 0.836190058727306 1.0 0.005406310488757 0.989065951515788 0.296960261475498 0.235333540565057 0.302366571964255 0.256964685804794 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCML4 0.888996070246995 0.115752263054674 0.507943638126037 0.423956980430881 0.447008527375422 0.761469121135878 True False False False False False False 0 insufficient_or_context_specific +PDHX 0.254462944277849 0.115943829538247 0.508107354047744 0.162347125409671 0.328357024765386 0.677287114006341 -0.130919421861202 0.67711571393548 -0.0660379989652458 0.800518868058649 -0.196957420826448 0.448908336133072 partial_or_other True False False False False False False 0 cross_species_direction_conflict +YJU2 -0.391943927363086 0.116127088129285 0.508433078366633 -0.390142777136155 0.11776378216747 0.497300322540835 -0.174864433317208 0.683680235761055 -0.490687139388885 0.141167070270616 -0.665551572706093 0.0765724351098435 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC087564.1 -0.95178299449787 0.11619064300324 0.508433078366633 -1.0217020361585 0.0897526479003072 0.470746198832535 False False False False False False False 0 insufficient_or_context_specific +IL1RAPL2 -1.11407077280738 0.116207116870952 0.508433078366633 -1.08141791513879 0.128230189083147 0.511467448560586 False False False False False False False 0 insufficient_or_context_specific +KCNIP4 0.779239756661638 0.116376982959635 0.508475415992879 0.621135026703619 0.206549601845956 0.579524500741323 True False False False False False False 0 insufficient_or_context_specific +CDON -0.586917364228951 0.116386820725811 0.508475415992879 -0.488250472730103 0.190160214081286 0.569886897607216 0.60399002465428 1.0 -0.770870369826621 0.0876181862376438 0.2792718586871 0.480180558395696 -0.491598511139521 0.230632712654361 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP4 -0.301841299030793 0.116513828492464 0.508475415992879 -0.100419253923864 0.627858574882432 0.857992157257607 0.26284796477217 1.0 -0.0182501065024384 0.949215265101553 -0.16238875421123 0.401361336040258 -0.180638860713668 0.376570606856671 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNIH3 0.499632622945359 0.116604838256453 0.508475415992879 0.423289913931932 0.187666934633619 0.56929178900529 True False False False False False False 0 insufficient_or_context_specific +CNNM2 -0.731581424116238 0.116664795003309 0.508475415992879 -0.193083191347186 0.668102561783984 0.875707864347027 -0.098356713012568 0.815171844574446 0.0383301931583171 0.911216690198559 -0.0600265198542509 0.871466359950182 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AASDHPPT 0.470130955240042 0.116719084808432 0.508475415992879 0.524037062466494 0.080089923223914 0.460059526331928 0.0297230993027259 1.0 -0.42833735866606 0.134196560308623 0.248122334296314 0.315586382506585 -0.180215024369745 0.501314906807036 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AKR1C2 0.809549466726567 0.116763810313223 0.508475415992879 0.7818052664016 0.132489205591638 0.518682589655195 True False False False False False False 0 insufficient_or_context_specific +GNAO1 -0.449937652429785 0.116842827719456 0.508475415992879 -0.537544178690363 0.0553935816165209 0.421331649096072 -0.809330680245954 0.130855823148545 0.637143160226458 0.159127265052075 -0.172187520019496 0.738399289449942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP2R3B -0.498598057243556 0.116852166738067 0.508475415992879 -0.40149624558919 0.212040422273631 0.584734997650585 0.5584921380932572 1.0 False False False False False False False 0 insufficient_or_context_specific +AL138752.2 0.333860795949263 0.116931262204278 0.508475415992879 0.263529717590144 0.224836274146324 0.596849502027745 0.0384466653668069 1.0 True False False False False False False 0 insufficient_or_context_specific +ELOVL2 -0.953635178743829 0.117279693674421 0.509144328048741 0.381919306746565 0.563380888127664 0.823754286312897 -0.689296655310163 0.0944377197348232 1.18262998035966 0.0075164545594183 0.493333325049492 0.187778767803111 reversed False False False False False False False 0 insufficient_or_context_specific +GALE -0.662961798170667 0.117382399861426 0.509172485612679 -0.599639164837336 0.161006337166625 0.543541307772207 0.3564701448275839 1.0 0.242631893089642 0.681271067162771 -0.935060574290661 0.0533941597770093 -0.692428681201019 0.172330687839309 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NHSL1 0.35140984979758 0.117400264749279 0.509172485612679 0.334499958514453 0.136601288119 0.523136620282319 0.102604051800638 0.0751057047947904 2.0 -0.95305188697725 0.0118902233379293 0.49748474589979 0.10456082029402 -0.45556714107746 0.147988958903565 reversed True False False False False False False 0 cross_species_direction_conflict +PAK4 -0.352304313048751 0.117672847519539 0.509172485612679 -0.46912402419224 0.0335010254861396 0.376280667109215 -0.302679868179242 0.443509464257184 0.0026649398444437 0.995400663291026 -0.300014928334799 0.390564341587167 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NSUN6 -0.376858725805551 0.117685052386159 0.509172485612679 -0.395043570198724 0.100228875596703 0.478125555523304 -0.533298663523334 0.195969442554011 -0.289278421984811 0.428801094481964 -0.822577085508146 0.0465924469552836 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCG8 -1.01965260974926 0.117791828453705 0.509172485612679 -1.14388824675289 0.0754832867142398 0.453930920096201 -2.41007006058569 0.0006690048699659 1.49933304281935 0.0080963878427477 -0.910737017766338 0.0537894975346923 reversed False False False False False False False 0 insufficient_or_context_specific +STEAP3 -0.733828835224331 0.117797963373369 0.509172485612679 -0.738120639382553 0.116021831434734 0.494328725999491 -0.587010520254015 0.207950586340766 0.247294127351511 0.540194763996341 -0.339716392902503 0.424552274160848 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPN1 -0.359433850264988 0.117909397294692 0.509172485612679 -0.43779321973579 0.0543640869695125 0.419106270466538 0.7423011628102091 0.450386214525087 2.0 0.0943860458915514 0.78150381255069 0.0129663271196811 0.964162706928666 0.107352373011232 0.709113721153133 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NADK -0.525748511368292 0.117915872381869 0.509172485612679 -0.572327670502313 0.0876710583195203 0.468622105620855 1.24740081450615 0.0166527949006225 2.0 -0.195214614284936 0.555207867663433 0.294430701469068 0.273859068736035 0.0992160871841318 0.747676390820937 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABHD17A -0.498733208326615 0.11792849701829 0.509172485612679 -0.534689773334144 0.0905306914759509 0.472234212482528 0.952837502649104 1.0 0.190072515070456 0.628313222217819 0.0793532579468187 0.811619804244142 0.269425773017275 0.413955319965021 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NECTIN2 -0.51825679749137 0.117961346827866 0.509172485612679 -0.798639598491469 0.0099989279316092 0.301624803148371 0.184313442472692 0.251230760079945 2.0 -0.256579678955521 0.350494329198229 -0.591196455674494 0.0255772150791541 -0.847776134630014 0.0076424376952449 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL6 0.369768763801081 0.11810206458215 0.50943586458486 0.562565019523047 0.01649142543151 0.325489753822016 0.6668333845518399 0.0448260410545343 2.0 True False False False False False False 0 insufficient_or_context_specific +MRPS27 0.366045256419059 0.118118866878551 0.50943586458486 0.481970757778999 0.0375178542591908 0.379484931484566 0.356033623682649 0.6871817756792231 0.0821206796020446 3.0 True False False False False False False 0 insufficient_or_context_specific +SAP30L-AS1 0.374054858179284 0.118245353860259 0.509579194593006 0.265961228331926 0.262781407022979 0.625720815369556 True False False False False False False 0 insufficient_or_context_specific +FANCA -0.789559506499333 0.118248629167727 0.509579194593006 -0.820333417378401 0.10433092274063 0.480701786460493 2.61442564547234 0.0203668210600581 -3.64972519922795 0.0033471189363927 -1.03529955375561 0.503374028510362 reversed False False False False False False False 0 insufficient_or_context_specific +HDHD3 -0.580441660077705 0.118470192174216 0.509909616378058 -0.767150235121699 0.0381006666571986 0.379484931484566 -0.593106877980137 0.0667885641616118 0.381610547687526 0.17016844579459 -0.211496330292611 0.475020563310762 reversed False False False False False False False 0 insufficient_or_context_specific +C21ORF58 -0.674522337633983 0.118520341183302 0.509917588513977 -0.588392956275655 0.178893132372645 0.561794673286848 False False False False False False False 0 insufficient_or_context_specific +AC078845.1 0.97142381194221 0.118803776870808 0.510229455706911 0.353134553980527 0.539472946356672 0.812783927483158 True False False False False False False 0 insufficient_or_context_specific +VMP1 0.483206343903077 0.118826635021112 0.510229455706911 0.506813088586177 0.0993498049163702 0.478125555523304 0.201713732625947 0.115597441490982 2.0 -0.233065575844628 0.660094015161262 -0.450042097824403 0.283105821907691 -0.683107673669031 0.12461319926319 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PTBP1 -0.461452636229129 0.118834460274985 0.510229455706911 -0.373826397549205 0.212061972533064 0.584734997650585 0.369328090671155 0.266581190596065 2.0 0.0425297854451062 0.930814872698551 -0.016428851519278 0.966099984818301 0.0261009339258283 0.948349040881144 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC015712.2 0.757036974243667 0.119059871956493 0.510957753488216 0.776851095792489 0.110837578718413 0.488469027874715 True False False False False False False 0 insufficient_or_context_specific +CDC37 -0.4934442665716 0.119152531504398 0.510957753488216 -0.42619697970554 0.184201405203498 0.565716727964854 0.465861663097722 1.0 0.0539588467917076 0.885471018366295 0.289759301781898 0.257538702794201 0.343718148573606 0.205765023937973 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MFSD1 0.379525387521089 0.119222429005723 0.510957753488216 0.302128157180492 0.218824902282635 0.591185598336761 -0.095135812743962 0.777601697847892 0.154606434694085 0.539487294984054 0.0594706219501233 0.842531613813403 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NOP56 -0.617195067509436 0.119260037573876 0.510957753488216 -0.758912915609211 0.046463480987671 0.398741839274603 0.274127769755165 0.385839800322049 -0.698723521617686 0.0204228386915211 -0.424595751862521 0.144253364253544 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF2B3 -0.260015386169138 0.11926758490047 0.510957753488216 -0.177175475788127 0.292667954494264 0.651509781962399 -0.231064652034605 0.579390512658833 -0.162064840812493 0.634541304329053 -0.393129492847099 0.270096218040465 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IFT81 0.288729374044395 0.119342902687376 0.510957753488216 -0.0281540461988228 0.87921077075671 0.961739257941291 1.11604666841851 0.85369399264378 2.0 0.454449222186611 0.205130934371804 -0.424226870473021 0.168252501936094 0.03022235171359 0.939103431814979 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CALCRL 0.618079454743266 0.119443990394616 0.510957753488216 0.750125506369609 0.0570474867387094 0.424455207563489 0.6326378223848571 1.0 -0.452829767569611 0.248083775024392 0.317550683676751 0.355408290279068 -0.13527908389286 0.729111396451669 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC17A2 -0.954106091494142 0.119475693838074 0.510957753488216 -0.723459506940873 0.244889666384302 0.610669341516615 -1.23990274838373 0.0190159467604389 1.36499693034818 0.0092768518657045 0.125094181964449 0.80052375194734 reversed False False False False False False False 0 insufficient_or_context_specific +UBTD1 -0.485309224100359 0.119536432195103 0.510957753488216 -0.0809723427082545 0.800881951853047 0.930221303373429 0.303611087414473 0.335546790750965 -0.222192122388746 0.396188268577813 0.0814189650257263 0.799661631189171 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF507 -0.28779150291853 0.119697243818298 0.511231189414882 -0.0025695527250096 0.988493660944667 0.996718493722613 0.9300989058181809 1.0 False False False False False False False 0 insufficient_or_context_specific +PPT1 -0.480437630951217 0.11975993294989 0.511292103552339 -0.365716281856857 0.244367470207364 0.610669341516615 0.0307460855658751 0.935285427653295 0.230888726766206 0.355523158408844 0.261634812332081 0.322958990591 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FEZ1 0.396993849333019 0.120070571486014 0.512184940026384 0.291238864347853 0.2610166085062 0.623754724597097 True False False False False False False 0 insufficient_or_context_specific +ONECUT1 -0.952324145477707 0.120114596657068 0.512184940026384 -1.12755405410324 0.0626197365840333 0.43268270867423 -1.46934425959951 0.175144956637759 0.288581327522384 0.783267499096172 -1.18076293207712 0.231897246435779 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CFAP36 0.379092373354777 0.120322954363534 0.512766609471001 0.31187568102398 0.206013681417355 0.578776160707106 0.0397529796316099 1.0 -0.0360718077866042 0.941986184105119 0.025807442496505 0.943946900587091 -0.0102643652900992 0.981691220990608 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EPS15L1 -0.209833743914078 0.120348139635266 0.512766609471001 -0.094813101467684 0.483236739566659 0.780666906162311 0.10337453079243 0.774467273972516 -1.0314117924417 0.0040155626029722 -0.928037261649267 0.010395894143059 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTC6 -0.775963463990923 0.120472558612755 0.513089662700069 -0.765975112004027 0.125916474957383 0.507996233320616 False False False False False False False 0 insufficient_or_context_specific +RABL6 -0.341129404057848 0.120602440187338 0.513401146844548 -0.518814785176484 0.0098344213732541 0.301445445011239 0.267614640993223 1.0 -0.0297072713401554 0.93061952943084 -0.210228948692318 0.355231462182272 -0.239936220032473 0.318426315942166 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LYN -0.387156417727507 0.120759511522744 0.513401146844548 -0.166266177675744 0.504578185855424 0.792758405693685 0.125945643657864 0.67284213551563 0.144918992695276 0.521363928093263 0.27086463635314 0.264943737889181 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYT7 -1.23340816988658 0.120821779060614 0.513401146844548 -1.1249044849256 0.161872866694707 0.543541307772207 False False False False False False False 0 insufficient_or_context_specific +MASTL 0.488663428436929 0.120975203607597 0.513401146844548 0.144195321888844 0.65327162800076 0.870639750062571 True False False False False False False 0 insufficient_or_context_specific +AC008758.1 -0.526091751675969 0.12099584370513 0.513401146844548 -0.700139574057023 0.029037314816696 0.369232614592462 False False False False False False False 0 insufficient_or_context_specific +EFNB2 0.977469177494697 0.121030626568489 0.513401146844548 0.0961933025550477 0.870607898711792 0.958683313195135 -0.536882450615897 0.512413411705759 -0.513691106588294 0.455975211582673 -1.05057355720419 0.154799513622228 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EGLN1 0.300965024730428 0.121088181398448 0.513433341046111 0.154718924081447 0.434206526660516 0.751847362038176 -0.252250555880115 0.340874190274872 0.34016973826697 0.135347194557071 0.0879191823868557 0.734770914728387 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RBP5 -0.691834383155827 0.12132115934301 0.514034103884307 -0.459883086695083 0.307913733363054 0.662243470533128 0.446681899443128 0.0110912832523446 2.0 False False False False False False False 0 insufficient_or_context_specific +DCAF10 0.292644787208472 0.121327238764889 0.514034103884307 0.205909851958118 0.274726909758669 0.638427515212424 -0.106007929869135 0.76367199399199 0.221731042858939 0.387735854741931 0.115723112989804 0.697133192453199 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF483 0.360751841572586 0.121422999003544 0.514233463088414 0.325578509918612 0.165056571354715 0.545094551255265 True False False False False False False 0 insufficient_or_context_specific +PEX14 -0.252739316166851 0.121669764455257 0.514532640547624 -0.107084733105548 0.503499596084042 0.792478940884811 -0.149988851490633 0.616511684944781 0.299623410756005 0.205984787161226 0.149634559265371 0.565121245216427 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLC4 -0.499548787003893 0.121708311020096 0.514532640547624 -0.607270944793836 0.0553696465642611 0.421331649096072 0.484445957518289 0.630764669318517 2.0 -0.41886994691892 0.108510320725145 -0.291341185691351 0.206633324845706 -0.710211132610271 0.0138105850453239 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM160B2 -0.341465172974037 0.121749574326383 0.514532640547624 -0.1912180625984 0.381984687773264 0.718125771636418 0.0902844910059942 0.84336036558253 -0.749285484455131 0.0319042904077129 -0.659000993449137 0.0713052066473725 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM20A -0.840842316549655 0.121781853937936 0.514532640547624 -0.912457158586474 0.0925656935353322 0.472460751419842 -0.48062730539273 0.166068813766625 0.608936484528158 0.0519979268681754 0.128309179135428 0.705527564044774 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RGS16 1.14667463921414 0.121875663424731 0.514532640547624 0.976276520002589 0.188800600870316 0.569351952070621 0.423340528522628 0.117492048683195 2.0 -1.55435587258443 0.483376911657878 3.33392155271891 0.05780700163088 1.77956568013447 0.271001223412665 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PSD4 -0.931459827392638 0.12192460980481 0.514532640547624 -0.937839023926676 0.119288906677558 0.499900248662619 1.34390734618532 0.112916119232733 -0.671043500153914 0.250554633787969 0.672863846031408 0.427455556149829 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF746 -0.38526911469544 0.12193883803608 0.514532640547624 -0.33506624362535 0.183621429160971 0.565541146173142 False False False False False False False 0 insufficient_or_context_specific +NAB1 0.352080762730669 0.121940753715127 0.514532640547624 0.526572492975522 0.017605616424867 0.326204572615871 0.0516387258401153 1.0 -0.0223865843004009 0.955742927437354 0.0048781916657169 0.988518306761756 -0.017508392634684 0.958216666061011 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRKCSH -0.392568066456238 0.122054842205709 0.514545647784519 -0.37501207313208 0.141566502328534 0.526923646040233 0.127671142288773 0.255171110171624 2.0 -0.260501890958895 0.289507124008915 0.276739451573464 0.195157978375258 0.0162375606145692 0.950390582138376 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PODN 0.424876881541985 0.122081535110837 0.514545647784519 0.170964990974825 0.526835812869319 0.804819865166353 0.9845732171516809 0.582465553273946 0.212236362457176 3.0 -1.61829570410032 0.0001979531072831 1.11357112586465 0.0021551896597206 -0.504724578235672 0.0646769073586702 reversed True False False False False False False 0 cross_species_direction_conflict +ZNF121 -0.406023715689057 0.12221943623633 0.514921311964554 -0.117237743029579 0.665603313947846 0.87511808324756 False False False False False False False 0 insufficient_or_context_specific +PSMC2 0.395626008595373 0.122363831140143 0.515324024402724 0.536088095294075 0.0361005218692925 0.37720666979567 0.500572617263308 0.0364793243592148 2.0 -0.193547820161393 0.505595986712893 0.607675813829882 0.0212882568194961 0.414127993668489 0.103736448352169 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZDHHC11B -0.757426476093127 0.122514224806206 0.515751668861213 -0.719229478379755 0.144215140415336 0.531456702445067 False False False False False False False 0 insufficient_or_context_specific +ZNF788P 0.546051101221895 0.122612646342762 0.515846881568203 0.573232298387428 0.10620033242883 0.483261130274234 True False False False False False False 0 insufficient_or_context_specific +CDH23 -0.742407422728055 0.122634558887686 0.515846881568203 -0.906659309367798 0.0571013233030413 0.424455207563489 0.348866411603999 1.0 False False False False False False False 0 insufficient_or_context_specific +AP000550.1 0.6609381189024 0.122851926322987 0.516349776320899 0.767650684291858 0.0747033358424268 0.452862231765951 0.0432247310018119 1.0 True False False False False False False 0 insufficient_or_context_specific +VAC14 -0.328028745633571 0.123026667523271 0.516672854300199 -0.364007360297951 0.0872557367167563 0.468350822702345 0.10074202072529 0.77561411900917 -0.719070180749674 0.0169307228026709 -0.618328160024384 0.041371657569802 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP001831.1 0.554245303854588 0.123395260732687 0.517202219794854 0.176528201525836 0.639644876729059 0.864573988534439 True False False False False False False 0 insufficient_or_context_specific +ZZEF1 -0.18391227131786 0.123491475385155 0.517202219794854 -0.0948720965823186 0.428265264054788 0.74799415349718 -0.176505477109671 0.593788663106486 -0.194172527131541 0.465368102283805 -0.370678004241211 0.188540718285251 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CASC2 0.521810230245942 0.123523387777758 0.517202219794854 0.561788007363891 0.097602011034989 0.478125555523304 True False False False False False False 0 insufficient_or_context_specific +LMBRD1 0.298984510217182 0.123534879197033 0.517202219794854 0.273464340251333 0.159986736563547 0.543541307772207 0.0736165577099832 1.0 -0.123994867452402 0.648819614351917 0.452599245776049 0.0454142531648201 0.328604378323647 0.146406527335482 partial_or_other True False False False False False False 0 cross_species_direction_conflict +UBE2Q2L 0.653214312192544 0.123544610562855 0.517202219794854 0.189639561858393 0.648016447127739 0.86855377695836 True False False False False False False 0 insufficient_or_context_specific +BTBD19 -0.565128778259534 0.123631226774403 0.517353318061617 -0.571119715079857 0.120503209498624 0.501524675000431 0.687834041276074 1.0 -0.149067694360566 0.838400398534546 -1.24236114007406 0.03496143266093 -1.39142883443462 0.0312332760254724 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAP2A 0.659534634270744 0.123678705700656 0.517353318061617 0.812862417434959 0.0579833998859498 0.426512790230505 0.04813414272609 1.0 -0.0381593543501304 0.925502799508407 -0.144706994441726 0.598691559075759 -0.182866348791856 0.54510140064968 partial_or_other True False False False False False False 0 cross_species_direction_conflict +UVRAG 0.236016581422748 0.123753632851394 0.517432491191746 0.261333470169304 0.0862123272105974 0.467677448123587 0.4734984231712751 1.0 -0.136489684757646 0.617987322967523 -0.225081358540797 0.301590711297135 -0.361571043298443 0.121603292560321 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SZT2 -0.251568670901711 0.123963502443552 0.517636806603747 -0.117650987364236 0.485973760747443 0.782071323676502 -0.0206724982942596 0.950789123793711 -0.358214113448914 0.115791387448757 -0.378886611743173 0.122892821589736 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR89 0.432422383420955 0.123991616205804 0.517636806603747 0.397159259920577 0.159737943238967 0.543504910610905 True False False False False False False 0 insufficient_or_context_specific +TEX41 0.639963200756097 0.124294280488857 0.518286724559294 0.79278075620374 0.0548562784371796 0.420068725637921 1.32428415592992 0.164420565697322 0.14414933917783 3.0 True False False False False False False 0 insufficient_or_context_specific +CLDN12 0.391694239620397 0.124294562093591 0.518286724559294 0.381782252840932 0.134423410607512 0.520900171021663 0.0315607344656346 1.0 -0.217438075105782 0.561355070181438 0.396382230966939 0.186561108871978 0.178944155861157 0.589094915401136 partial_or_other True False False False False False False 0 cross_species_direction_conflict +INTS13 0.396538087518388 0.124351991903699 0.518321488558726 -0.0213322593096733 0.938165120220821 0.983238767052951 0.133264725066501 0.754677169132923 -0.237020510204382 0.446266329746015 -0.10375578513788 0.78370087562633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COA1 0.233783417220885 0.124412730558249 0.518370011536696 0.19641677227229 0.198051797277086 0.573042169265956 True False False False False False False 0 insufficient_or_context_specific +COQ5 -0.427908274093205 0.124531582232051 0.518625671241816 -0.539598391180001 0.0466499375160813 0.398865057227663 -0.341317797803452 0.268640494859393 0.22744585219586 0.387763229835042 -0.113871945607592 0.707254917340578 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACTG2 -1.50451397677074 0.124650766049735 0.518747649961805 -1.56418122218625 0.112409478583618 0.491436552747761 False False False False False False False 0 insufficient_or_context_specific +LINC01301 0.45034948707471 0.124871140879512 0.519255417647061 0.228403457562395 0.449843361074256 0.763939182518913 True False False False False False False 0 insufficient_or_context_specific +AC006581.2 -0.628448990367876 0.124978478912346 0.519292711671211 -0.581702573427622 0.158770442891396 0.543060696740211 False False False False False False False 0 insufficient_or_context_specific +BCL6 0.52767383220872 0.125107876115861 0.519465490223309 -0.0526972896442254 0.881013047909141 0.962514047995106 0.157284041466905 0.136838191825293 2.0 -0.377553042524964 0.675515331505538 0.566995171380397 0.416179992973872 0.189442128855433 0.817704986063799 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BCL7A 0.467325508690585 0.125198096911592 0.519591787418469 0.171045363851923 0.592745876919632 0.838902274600198 0.391707719622603 0.3993620956113571 2.0 -0.0824452351976086 0.847150754208984 -0.454215110429756 0.134467029458025 -0.536660345627364 0.102260639737554 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ABCA10 0.492378199811274 0.125389113745147 0.519948137562422 0.335460947478352 0.311226985723219 0.66386306487225 0.117118891143905 0.134326468994076 2.0 True False False False False False False 0 insufficient_or_context_specific +CDC34 -0.380598004231167 0.125408581303663 0.519948137562422 -0.265876598887958 0.292917065082677 0.651509781962399 -0.168854360426472 0.634753771908475 0.17966114444315 0.530971450255766 0.0108067840166775 0.976408760603504 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NEK4 -0.290720346891495 0.125531553610263 0.51995871645677 -0.214543327474881 0.252651803363296 0.618991529980024 0.361720202605578 0.455080336983835 -0.01505325414373 0.972450972033354 0.346666948461848 0.419891485874905 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CR381653.1 0.561596824054569 0.125532749407871 0.51995871645677 0.364783450595433 0.323347044790095 0.673618409410778 True False False False False False False 0 insufficient_or_context_specific +BCL9 0.574474048563807 0.125649204635024 0.520236981386895 0.334008500958305 0.364412530918987 0.705850610221272 0.437237073934094 1.0 -0.161865946767488 0.673558453118714 -0.217146072448768 0.460044073614407 -0.379012019216256 0.232129112925826 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RNF24 0.579811330866054 0.125738921450048 0.5204043640414 0.721875805442227 0.0529505960619967 0.416277817549129 0.518107279432265 0.144988285734572 0.145644169585413 3.0 -0.583041034346391 0.438577085261165 -0.0029602513265239 0.996782557292892 -0.586001285672916 0.379756005764011 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ASB16-AS1 -0.409566299361084 0.126040085596771 0.5210380672399 -0.413252244485103 0.12204365065808 0.5038394341269 False False False False False False False 0 insufficient_or_context_specific +TTPAL -0.693238073520669 0.126230704822086 0.521332662787286 -0.843596297384634 0.056597037857687 0.424397390412969 -0.234212305681496 0.468839098744151 0.23448967185119 0.367488948356123 0.0002773661696939 0.999520876404913 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DLEU2 0.437196767484535 0.126231999548124 0.521332662787286 0.228459056380534 0.429071529816493 0.748336221434264 0.156980944010248 0.145350485712112 2.0 True False False False False False False 0 insufficient_or_context_specific +DPP6 -0.524288272995085 0.126606137926827 0.522180752701602 -0.640114019665657 0.0605936723522985 0.429268745755419 False False False False False False False 0 insufficient_or_context_specific +TFDP2 0.369188627296417 0.126613253165003 0.522180752701602 0.223073462967977 0.366620605825728 0.707896919588155 0.114744568782355 0.183538570071014 2.0 -0.0499154408164663 0.923269418503395 0.448567102439004 0.178294276757603 0.398651661622538 0.270863428326051 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SFSWAP -0.208169732159387 0.12672525336853 0.522427308990342 -0.207517754832788 0.126547850998315 0.508384607335028 0.0412444096422537 0.908403892865012 -0.622846283980494 0.0226156610485279 -0.581601874338241 0.0369867098470146 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPM1E -0.775328012774145 0.126856667179056 0.522427308990342 -0.591773375284244 0.260566779775444 0.623334744509154 False False False False False False False 0 insufficient_or_context_specific +ALDH1A2 -0.690236176096093 0.126886716720585 0.522427308990342 -0.670053459251035 0.139072756739168 0.524072738828147 -0.257266719821204 0.812410751771662 -1.53541791292514 0.0781598317302911 -1.79268463274635 0.0607086442084818 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OSBPL11 -0.406798540756735 0.12696992563641 0.522427308990342 -0.361442109745798 0.177844008069036 0.560500608117279 -0.156193910257182 0.685678336076267 -0.110320965215101 0.724666847465464 -0.266514875472283 0.403315594089091 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDX51 -0.558467136906374 0.127052358577147 0.522562836718939 -0.374103454330817 0.315015952910669 0.66732312015065 0.384095460341996 1.0 -0.303883739549433 0.526915243985124 0.000532584214623 0.998875117093705 -0.30335115533481 0.470258126377245 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PAPOLA 0.231637993384063 0.127167672657112 0.522687268546001 0.277276398790253 0.0618471890135958 0.431813959784778 -0.122401549810375 0.667781503126533 -0.268188590841387 0.231734487087436 -0.390590140651762 0.10343134893605 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRRAP -0.190914180055998 0.127181624634844 0.522687268546001 -0.190367782470633 0.126560966835076 0.508384607335028 0.471427356952746 0.0606656035367738 -0.544059175875348 0.0227294805695136 -0.0726318189226018 0.776776906434958 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC1A2 -0.625528800700466 0.127432719192121 0.522820192778903 -0.242608656286328 0.559607938278182 0.82190396702977 0.6977981462149351 1.26536362525305 2.0 -5.66573233393877 1.4021996351485e-05 4.97627012935567 7.35372894650181e-05 -0.689462204583101 0.0866643651409392 reversed False False False False False False False 0 insufficient_or_context_specific +SPIRE2 -0.679435296906357 0.127451454404912 0.522820192778903 -0.570536747124988 0.205692761926543 0.578776160707106 False False False False False False False 0 insufficient_or_context_specific +COX5B 0.509623606343844 0.127494289459962 0.522820192778903 0.609919163066302 0.0690016774668296 0.439661865235237 -0.171571218701151 0.704859637739998 0.379834182631257 0.280487442046294 0.208262963930106 0.589318664756369 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CUX2 -1.42146274428477 0.127511081303815 0.522820192778903 -1.50377500903488 0.106884328197832 0.483261130274234 False False False False False False False 0 insufficient_or_context_specific +SPOCK1 0.781944376357924 0.127746617979845 0.523444832753243 0.849289737955864 0.0995361191435121 0.478125555523304 True False False False False False False 0 insufficient_or_context_specific +KITLG -0.904552040736349 0.12781137052579 0.523444832753243 -0.5464613365025 0.363213016043817 0.704765682869143 False False False False False False False 0 insufficient_or_context_specific +IGHMBP2 -0.434579558698217 0.127812159389833 0.523444832753243 -0.371682019409776 0.196077467959527 0.57171662709657 1.62301230714195 1.0 -0.0740145027312531 0.888756317097729 -0.520182239181185 0.155387013884642 -0.594196741912438 0.139517220109242 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIM33 0.251765677677929 0.127908448259277 0.523636059217313 0.363017082102615 0.0224108021074206 0.346028040476539 -0.0367522704577196 0.943656914942439 -0.385764322127103 0.26416229599934 -0.422516592584822 0.26115363878731 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TF -0.726032510265129 0.128010010427448 0.523848717090309 -0.683072302200443 0.153865037076746 0.536703874670957 False False False False False False False 0 insufficient_or_context_specific +GATD1 -0.396877933114741 0.128073642376933 0.523906050451629 -0.571151381145031 0.0224895457534615 0.346028040476539 0.247407177605838 0.457696546809139 -0.311753575986934 0.245913175589008 -0.0643463983810953 0.848856992637175 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERMAP -0.46308905311144 0.128305509013666 0.524651264200728 -0.773645727994343 0.0088783489780965 0.291509786412688 False False False False False False False 0 insufficient_or_context_specific +LEMD3 0.291864229898717 0.128644340793113 0.525523400646232 0.279196260887822 0.146168278026358 0.532796338690088 -0.175216327831755 0.604968023577395 -0.0703409440049095 0.807603598431137 -0.245557271836664 0.394217441513004 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TSHR -0.642526828387969 0.128668118078283 0.525523400646232 -0.40145594294723 0.37729952180492 0.714534233402035 False False False False False False False 0 insufficient_or_context_specific +RPH3AL -0.725084008621306 0.128739713343087 0.525612487809867 -1.10992833640035 0.0139748865370052 0.314756631908661 1.01925280969902 1.0 -1.0701123340543 0.174836620623234 -0.38784375489126 0.616575323165966 -1.45795608894556 0.0662048066989493 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FILIP1 -0.412878273730703 0.12890841352325 0.525894524721204 -0.448301055813196 0.0997903144867256 0.478125555523304 0.509634628408147 1.0 False False False False False False False 0 insufficient_or_context_specific +NUB1 0.388509536899955 0.129092952842848 0.526443953694396 0.132270414788064 0.606528533123936 0.846931578987574 0.3992298811574679 1.0 -0.556483661978502 0.0170851660132789 0.224256017573712 0.239615881413648 -0.33222764440479 0.104275300791958 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM20B 0.228272987001571 0.12920707811333 0.526705919197117 0.23689351695781 0.114513370670451 0.492613299848511 0.347919891973974 1.0 -0.0743492168457821 0.853881890918567 0.0467252690952944 0.882820155902677 -0.0276239477504877 0.93677237373711 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ACAD9 -0.304336553742959 0.129271795614209 0.526766352024244 -0.0426654378409493 0.831867988562561 0.944495346084903 0.589641275934193 1.0 0.0293637080190746 0.951317427671677 0.190351980678458 0.551852971618274 0.219715688697533 0.533335368241833 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GRIK2 0.83296927658006 0.129518713702558 0.527302173965225 1.08836984284799 0.0474867468243898 0.401413188928669 True False False False False False False 0 insufficient_or_context_specific +AL035530.2 0.418630593299812 0.129521720183302 0.527302173965225 0.425732400251587 0.123560385522324 0.505248083014988 True False False False False False False 0 insufficient_or_context_specific +C11ORF74 0.570013018279174 0.129741485174677 0.527676589304428 0.520902421544492 0.169023461689257 0.548585831083667 True False False False False False False 0 insufficient_or_context_specific +ZNF565 0.503889179922747 0.12974506780018 0.527676589304428 0.551728349879355 0.0952634933130965 0.475183542244264 0.0384734300389465 1.0 True False False False False False False 0 insufficient_or_context_specific +MRPL4 0.608983804208807 0.129825550276957 0.52780060062538 0.355667927574164 0.370831140735369 0.709933692593666 True False False False False False False 0 insufficient_or_context_specific +SCAI -0.33002417344489 0.130020592995896 0.528140364327409 -0.152671541923785 0.481142444010063 0.78036214643277 0.328012605379034 1.85352332353708 2.0 -0.222264003591807 0.596454233907932 -0.691369356752226 0.0550081036897018 -0.913633360344034 0.0260063020234298 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IGFN1 -1.21199758268621 0.130121479523236 0.528140364327409 0.487671120053962 0.568321851555745 0.825129552905055 False False False False False False False 0 insufficient_or_context_specific +MIDN -0.593301585101987 0.130163580927727 0.528140364327409 -0.637052817650298 0.102074455201795 0.479137456027696 0.77573809491257 0.745764692537542 2.0 0.421561488617851 0.131669356927171 -0.345109144511988 0.162199618103818 0.0764523441058626 0.790365236073199 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL390957.1 0.372691208059213 0.130219742852756 0.528140364327409 0.103703581059955 0.68576189408294 0.883592781626934 True False False False False False False 0 insufficient_or_context_specific +AC068724.3 0.591369690346815 0.13025118197822 0.528140364327409 0.323075437362257 0.406933569735307 0.733976772200131 True False False False False False False 0 insufficient_or_context_specific +CCDC57 -0.351958854379526 0.130309305651913 0.528140364327409 -0.423954319525211 0.0654904353087481 0.435533238803682 0.5505802304229921 0.620737622485424 0.0805754704886523 3.0 -0.420517868810203 0.359426564889417 -0.39775416306749 0.313152376086006 -0.818272031877692 0.0644766181655733 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM25 -0.333588201743658 0.130369112603118 0.528180004168735 -0.417421231216229 0.0502860437997966 0.405592093535716 0.117465540946499 0.739984078355744 -0.39624465147197 0.145484121034829 -0.278779110525472 0.326591166575911 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLR2A -0.35956998265292 0.130470508997005 0.528388045259065 -0.491245380341886 0.0341956778895242 0.376543096535729 -0.0354603604194701 0.912230769189661 0.385479709848076 0.0775667868234661 0.350019349428606 0.126012114865698 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC084337.2 0.420520558466684 0.130771911407137 0.529201783508963 0.284569789368752 0.31102143720247 0.66386306487225 True False False False False False False 0 insufficient_or_context_specific +RBPMS2 -0.6706700223812 0.13082180857723 0.529201783508963 -0.508952276238879 0.264901663376163 0.627937081707572 -0.692598469334842 0.113150252614325 0.763843182128204 0.0553744195062967 0.0712447127933619 0.876653908549122 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZC3H3 -0.416981402483902 0.131010407026959 0.52976173013812 -0.283356662182911 0.311236000967336 0.66386306487225 0.678840542015348 0.380957488156187 2.0 0.204716016110089 0.5728361407637 0.189241335574759 0.491211346226698 0.393957351684848 0.198157856820249 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RUNDC1 -0.394373028103136 0.131087413093481 0.529870178959024 -0.537847396885191 0.0423208509084664 0.3908928278867 -0.298406810134344 0.449388150561601 0.165483851440872 0.619483895538999 -0.132922958693471 0.722902816427028 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC012358.3 0.508970308485341 0.131246100716715 0.530308584526245 0.518729805466234 0.12484610548151 0.50716327219255 0.0458344339111309 1.0 True False False False False False False 0 insufficient_or_context_specific +PPTC7 -0.374320022943339 0.131539098500037 0.531062284493215 -0.25673911095665 0.309534265587358 0.662858728430055 -0.353695642455139 0.337486907631087 0.297963869563758 0.331762042541444 -0.0557317728913815 0.885032422574932 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LGALS8 -0.281277706050286 0.131679772071045 0.531062284493215 -0.0427807619084949 0.819317306037277 0.937605909076693 -0.19699518233844 0.483421785618699 0.0126372799481479 0.963232153347549 -0.184357902390292 0.457609128358517 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COPZ2 -0.512328428181678 0.131757078075887 0.531062284493215 -0.262278769042376 0.459332096501134 0.768440544265406 0.260836055640772 0.371632881575903 -0.0246044523354462 0.930852252028654 0.236231603305326 0.370100026705007 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HNF4A-AS1 -1.54312001723319 0.13180360398679 0.531062284493215 -1.64887475509707 0.105461918026762 0.482830329046451 False False False False False False False 0 insufficient_or_context_specific +NACC1 -0.557123622435675 0.131866539696665 0.531062284493215 -0.389343160609029 0.309643800778276 0.662858728430055 0.368502071433721 1.0 0.644154786349501 0.053032061413272 -0.205972018308321 0.444496793110043 0.43818276804118 0.151751281577038 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEMA3A -0.683993551002308 0.131867721839084 0.531062284493215 -0.402499394246526 0.374866915436085 0.712838905321506 0.538208831704807 0.485448184647571 -0.0113262739021406 0.98660432066316 0.526882557802667 0.438233521381342 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FOXRED1 -0.340934272080325 0.13188096734065 0.531062284493215 -0.522148012854845 0.0224334272982653 0.346028040476539 0.331516452297526 0.300161201299016 -0.0808336981200102 0.77705437383924 0.250682754177515 0.392790197339708 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEPT4-AS1 -0.59932312901677 0.131885329602312 0.531062284493215 -0.608130729868436 0.126181083825536 0.508384607335028 False False False False False False False 0 insufficient_or_context_specific +CCAR1 -0.187875042977153 0.132006381694805 0.531281560887135 -0.186958821769801 0.132057886066486 0.518314929773221 0.115196407895404 0.644039537671578 -0.553020469864978 0.0151611856084994 -0.437824061969574 0.0487428442069742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBL2 0.331173073908968 0.132040425816238 0.531281560887135 0.154027770361182 0.492803096367925 0.786325382313799 0.0623097692169833 0.0853098632712553 2.0 -0.0931708297595726 0.80195152442622 0.472316678353024 0.0807629273793783 0.379145848593451 0.178994249633 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GCC2 0.27161305033287 0.132610509927704 0.532763228240752 0.172154359881126 0.342906943852222 0.689733570811918 0.275942822113373 1.0 -0.326172314030978 0.320349903765884 0.550394182079989 0.0579293152670708 0.224221868049011 0.448908336133072 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM68 -0.314506086658737 0.132677859368088 0.532831053331407 -0.216622963849735 0.304973198965574 0.661381253594365 0.34572774019403 0.23546237458658 -0.300365406953533 0.216173004713167 0.0453623332404968 0.886363082174233 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLASRP -0.252563190340834 0.132952421381964 0.53332510066519 -0.378439447030765 0.0229418098440592 0.346028040476539 0.377226505984982 1.0 -0.0871124407572761 0.859070568791721 -1.07683101263049 0.0102391053289871 -1.16394345338777 0.0105281160490977 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERGIC3 -0.456956578250586 0.133453837142292 0.534524132226222 -0.282294016511571 0.369162094766363 0.709345639075664 0.608519774372902 1.0 -0.068908496105849 0.848446754046341 -0.149385459223742 0.564070992057792 -0.218293955329591 0.415889736243133 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKRD52 -0.340944667840382 0.133511546403925 0.534552486512189 -0.434937040030592 0.0580310446673913 0.426512790230505 0.228662886448999 0.436748903286456 -0.51317388348466 0.0487575712308209 -0.284510997035661 0.279125202202979 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C5ORF15 0.283198341086808 0.133636483574136 0.534787768227256 0.0552785901867306 0.770826100161993 0.920631444062254 True False False False False False False 0 insufficient_or_context_specific +KLRD1 0.815035914377626 0.133690577509997 0.534787768227256 0.463195984902394 0.394898773935196 0.726080478554543 0.0357820890039082 1.0 True False False False False False False 0 insufficient_or_context_specific +MBD6 -0.739250235489197 0.134138583066668 0.535616764110931 -1.14816271130729 0.0151955055722768 0.320500116612027 0.4877346650401 0.3801919975126359 2.0 -0.0254592649699084 0.942765457377306 -0.670096510792659 0.0154742191171605 -0.695555775762568 0.0203378486623891 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC113414.1 -0.641281162965767 0.13421119893767 0.535616764110931 -0.896528298405861 0.0319092949298011 0.375031405408838 False False False False False False False 0 insufficient_or_context_specific +ITPA -0.420736437793784 0.134279872544021 0.535616764110931 -0.460756528762079 0.0977665089765814 0.478125555523304 0.246392927972861 0.364396958298434 -0.252473361753001 0.26635140154411 -0.00608043378014 0.984914814547429 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATXN3 0.359117896110269 0.134284425440576 0.535616764110931 0.187082702619727 0.435983859554164 0.753451320678163 -0.164002041865502 0.654052346887649 0.0439169195236606 0.893065127627134 -0.120085122341841 0.713674466352335 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM50A -0.459805639080438 0.134357704398234 0.535616764110931 -0.47412636732937 0.122103323246406 0.5038394341269 -0.0556811103781312 0.8801648634959 -0.0229220306929547 0.938168709893813 -0.078603141071086 0.793502768503351 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HYOU1 -0.574078429743425 0.134385645031098 0.535616764110931 -0.655888884407234 0.0855796685509648 0.467503293000484 -0.857646745965468 0.0301543872954763 0.683783340664122 0.0541904385029685 -0.173863405301345 0.63770109691292 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF484 0.511897985735966 0.134592841960295 0.535616764110931 0.327432462380473 0.339126129863729 0.686946959803023 True False False False False False False 0 insufficient_or_context_specific +ZFP1 -0.527409709775382 0.134726665299448 0.535616764110931 -0.613816236772012 0.0794757281194241 0.459160525051927 0.0072991401216875 0.98931579652119 0.201457753550648 0.559075740544916 0.208756893672335 0.595139012396859 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AMY2B 0.530045830655443 0.134934060690199 0.535616764110931 0.539841357007411 0.128681225027311 0.512298783498625 0.0245897578218036 1.0 True False False False False False False 0 insufficient_or_context_specific +SPTAN1 -0.333192063320521 0.135028553617524 0.535616764110931 -0.229895528916666 0.317475845934707 0.669290253214092 0.157837275797362 0.618787224556557 -0.327410368514528 0.198782071903694 -0.169573092717167 0.538941807163739 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARRDC1 -0.524791670094969 0.135038136670313 0.535616764110931 -0.370620438272089 0.308527644115991 0.662330926800867 0.0174234195971352 0.980581669633894 -1.25649962126086 0.0225787279297547 -1.23907620166373 0.0391192924005971 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC39A7 -0.626363098115625 0.135092246410062 0.535616764110931 -0.260745407915505 0.55230291226615 0.818875740444602 -0.0201371718771733 0.955901296169825 -0.315930277719323 0.200005584649011 -0.336067449596496 0.194093119192605 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF322 0.361582852700004 0.135123113388324 0.535616764110931 0.27906175523996 0.251080681854297 0.617783695879205 True False False False False False False 0 insufficient_or_context_specific +GSDME 0.51163122508064 0.135171944133799 0.535616764110931 0.203104788267062 0.554615721918272 0.819814244898102 0.8483716650763041 1.0 True False False False False False False 0 insufficient_or_context_specific +MAPK1IP1L 0.285104370845396 0.135180824923794 0.535616764110931 0.132045245012047 0.519487712360659 0.801047042355318 -0.0591262231076079 0.837892906728401 0.153159924994173 0.446978575173827 0.0940337018865647 0.683169836203475 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPS20 0.536148310021825 0.135232794965618 0.535616764110931 0.370582943836471 0.307155395117602 0.661701213710167 True False False False False False False 0 insufficient_or_context_specific +PALM2-AKAP2 0.476347752440822 0.135249344771354 0.535616764110931 0.633615899606878 0.0449607074711009 0.393650849907072 0.640191841961532 0.9292743067415121 2.0 True False False False False False False 0 insufficient_or_context_specific +RBM47 -0.740085910356095 0.135398817458447 0.535616764110931 -0.945913222369157 0.0532174751754923 0.416631456505827 0.4063789412294221 1.0 -0.541475031174416 0.0651740871366669 0.27870741043769 0.273165177608927 -0.262767620736727 0.324090186810208 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF562 -0.288670097412119 0.135448406589383 0.535616764110931 -0.16793774040698 0.401601403449162 0.730970076414215 False False False False False False False 0 insufficient_or_context_specific +TIMM23B -0.381183485455736 0.135456979659925 0.535616764110931 -0.293933444527933 0.256049230007034 0.620670263344767 False False False False False False False 0 insufficient_or_context_specific +AC007681.1 0.535317199884284 0.135470308638055 0.535616764110931 0.648256317621176 0.0688133222468078 0.438727346175897 True False False False False False False 0 insufficient_or_context_specific +PIGL -0.23266673478849 0.135681233036426 0.535616764110931 -0.265433811668259 0.0853711280863348 0.467261985658643 -0.163446871554539 0.819083985159194 -0.0052134710177101 0.993384042372739 -0.168660342572249 0.778602579261632 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAJC16 -0.213107792919595 0.135683953627135 0.535616764110931 -0.0825269766006533 0.572928941505397 0.827947408214342 0.649394108981764 0.472307871178835 2.0 0.0269378520932612 0.950029058814111 -0.385109449381777 0.180458365392657 -0.358171597288516 0.24796996006321 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CATSPER2 0.621475484589554 0.135683977496805 0.535616764110931 0.592401607448773 0.156203252058773 0.539558215777 0.0419330339312056 1.0 -0.270130817904355 0.614121189200058 -0.839565384649877 0.0663433936285876 -1.10969620255423 0.0340277104791189 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF251 0.261583538506642 0.135715891651303 0.535616764110931 0.469926461984409 0.0077346677832126 0.287862310479138 True False False False False False False 0 insufficient_or_context_specific +FGF13 -0.999733445386802 0.135787685042198 0.535616764110931 -1.43249026359177 0.0283127242568879 0.366994830293022 False False False False False False False 0 insufficient_or_context_specific +TCEA3 -0.628094014593237 0.135804607029527 0.535616764110931 -0.621117213796538 0.1408489302372 0.526401063874107 0.453246540449986 1.0 -0.900528854613683 0.0093548948439362 0.423496880982032 0.127750339925528 -0.477031973631651 0.102073049825762 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SORD -0.699028086123541 0.135806599500375 0.535616764110931 -0.784457572028474 0.0923925496789832 0.472460751419842 -0.0522165510042619 0.941986184105119 0.518628852314909 0.29003789478917 0.466412301310647 0.363502775590814 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01184 0.328467817084955 0.136038388869946 0.53614012301849 0.308331566527724 0.163168625274589 0.544298760692042 True False False False False False False 0 insufficient_or_context_specific +PFDN2 -0.496380980778567 0.136040859023161 0.53614012301849 -0.390557116841772 0.248283713522464 0.614136532744356 -0.105721489627848 0.732619581388593 0.438824015851174 0.0651813483869062 0.333102526223326 0.176858349190865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM66C 0.615924886997117 0.136161737370443 0.536416277297441 0.214622609281672 0.600863072057674 0.84360251650955 True False False False False False False 0 insufficient_or_context_specific +MUSK 0.759828951343302 0.136309889997445 0.53662997747927 0.303406719370236 0.55439546737183 0.819814244898102 0.695481409059636 1.0 True False False False False False False 0 insufficient_or_context_specific +OSGIN1 -0.869083184435134 0.13631763587795 0.53662997747927 -0.824458907585082 0.159208412828055 0.543060696740211 -0.669555399158826 0.128358165040228 -0.783659880162034 0.059333085226784 -1.45321527932086 0.006648094924408 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM110B -0.492182397041387 0.13639273145283 0.536725478449115 -0.0138309639349584 0.966586422221391 0.990805143378026 1.1121010632844 1.0 False False False False False False False 0 insufficient_or_context_specific +TXNRD2 -0.302206225130159 0.136571391723605 0.537028213712411 -0.463011354793726 0.020008741124966 0.332176266033792 0.4645719668610829 1.0 -0.302383218329272 0.20833541832002 -0.492624648010207 0.0336240795032459 -0.795007866339478 0.006351445639828 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC009554.1 0.455248045311822 0.136741958469627 0.537198696892096 0.506572733374065 0.0986316526485371 0.478125555523304 True False False False False False False 0 insufficient_or_context_specific +UBE2D2 -0.192420345241809 0.136752341785697 0.537198696892096 -0.0812718108384877 0.541578838586304 0.813832817790235 0.297266615768898 1.0 False False False False False False False 0 insufficient_or_context_specific +PRKAG2 -0.510317987160908 0.137010090051808 0.537352351696503 -0.665508239386314 0.0427800518891415 0.391483132487066 0.740493361189325 1.0 -0.397385004162445 0.192710521342495 -0.503789019304495 0.0729066936551299 -0.90117402346694 0.0104682629864625 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNA2 0.434491632104058 0.137273301573391 0.537488043399431 0.17909724751454 0.55650394503204 0.820941061653668 -0.555245912014605 0.350779143914235 -0.0398363043515766 0.944987483954994 -0.595082216366181 0.270132665736017 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PKN1 -0.298829042649095 0.137358261112277 0.537488043399431 -0.146070899960041 0.47785507104392 0.778545319644225 -0.301683940010386 0.200304406994427 -0.338061994580023 0.110052124829686 -0.639745934590409 0.0141698130704549 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTBP3 0.325347041646627 0.137362138226685 0.537488043399431 0.449642231446022 0.0368466347292106 0.378799191305751 -0.0531352860740052 0.869246189449544 -0.0243962710151663 0.926914036043855 -0.0775315570891715 0.769026048029419 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BDH2 0.547073456337841 0.137677362466484 0.537488043399431 0.650564391088706 0.0786075593207608 0.457322349441485 0.0406858866672361 1.0 -0.0663140764561103 0.953173095923033 1.19100474161279 0.0658843925485911 1.12469066515668 0.123366854142027 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC22A23 -0.749418765250745 0.137682439419013 0.537488043399431 -0.9543436772118 0.0590408577931213 0.428240742414856 -0.780970162087353 0.031842265577242 0.364339172579046 0.233185712458966 -0.416630989508307 0.193730781338835 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C2CD2 -0.370989649308258 0.137736647693242 0.537488043399431 -0.0167809362190186 0.950628465817353 0.986917609553614 0.5836492506112659 0.6776083638760939 2.0 -0.257095043351023 0.562633030035581 0.659034708619457 0.0725722252163001 0.401939665268434 0.282248959559426 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDX39A -0.514720521727168 0.137934373249848 0.537488043399431 -0.589494316562691 0.0871608071805482 0.468303538747472 0.427147364081916 1.0 False False False False False False False 0 insufficient_or_context_specific +MIIP -0.597116431549481 0.138016262240414 0.537488043399431 -0.552982916723912 0.176261467316587 0.558204137142182 0.692920853168921 0.634129474703781 2.0 -0.0577587687745429 0.884295687375294 -0.646568230018598 0.0307485111358307 -0.704326998793141 0.0309444487665193 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MGMT -0.288583462572695 0.138026588595485 0.537488043399431 -0.375875233762782 0.0510698839036779 0.40964799201548 1.41065425958894 1.0 0.213056977315222 0.500175020342632 0.209568532170825 0.403679171002468 0.422625509486047 0.126010540375426 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DCTN2 -0.35999414604173 0.138027407475004 0.537488043399431 -0.426647853289631 0.0758939402388713 0.45450267784572 -0.119312476522793 0.64023679664879 0.204987342119804 0.308310654471899 0.0856748655970108 0.709223603810013 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LONRF1 0.441304750431874 0.138057354625232 0.537488043399431 0.307986260773043 0.314123321374434 0.666635985340959 0.599053974947727 1.0 -0.199453970426417 0.749439872020868 -0.867173586406805 0.079933507600063 -1.06662755683322 0.0569652721246658 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM259 -0.573561873507757 0.138159327840392 0.537580642998895 -0.609021351121241 0.112896159775993 0.492341038791796 0.7161068980224801 0.449866373345497 2.0 -0.211988542742048 0.439864453842224 -0.338923084418782 0.149197160132819 -0.55091162716083 0.036634198569422 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EMC8 -0.324280356660236 0.138308350434586 0.53781086837707 -0.152855782452813 0.49345916098362 0.786363265568912 -0.0922434554688816 0.768408825074034 -0.438946368218545 0.06940398159636 -0.531189823687427 0.0468930610740237 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HSDL1 -0.466916661657518 0.13842216390845 0.53781086837707 -0.0900476774132888 0.782439789031135 0.924647355053618 0.297410051312847 1.0 0.0280673297615955 0.957989552701686 -0.236485919835297 0.496693546069234 -0.208418590073702 0.611988613677932 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE2J2 -0.347249158475345 0.138432010228565 0.53781086837707 -0.404593878714837 0.0796724836043881 0.459160525051927 -0.149094994779917 0.614987229899015 0.412558714781297 0.0809819276355828 0.26346372000138 0.283719455272511 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HLA-B 0.630070552083055 0.138502344299797 0.53781086837707 0.74619753531466 0.0781070374300756 0.457322349441485 True False False False False False False 0 insufficient_or_context_specific +SSBP4 -0.388578729973634 0.138756664043427 0.538524672109706 -0.382471475195307 0.145149323913217 0.532658823056677 0.377576940015438 0.25587569198414 2.0 -0.0915733875689302 0.852341521006602 -0.791841517231069 0.0362813230115863 -0.8834149048 0.0303524188451113 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDPK1 -0.222521647705024 0.138837918771043 0.538524672109706 -0.18197576674974 0.228828699074535 0.600424738880655 0.323583885290876 0.461594809492715 2.0 -0.0359522537757819 0.918157951904821 0.135270217949789 0.564815643453354 0.099317964174007 0.711700178196534 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BX248415.1 -0.502464559841057 0.138913397997481 0.538614636818732 -0.430964082243675 0.210477174678101 0.582800422305635 0.0260823209601893 1.0 False False False False False False False 0 insufficient_or_context_specific +PM20D2 0.349782569569343 0.138970763855745 0.53863925285938 0.225051543492946 0.352703471395253 0.696696585779436 -1.31776378662363 0.0532756248333769 0.928583721837261 0.103025106484495 -0.389180064786371 0.493271491051335 reversed True False False False False False False 0 cross_species_direction_conflict +ADRA1A -0.875187636612236 0.13907599211735 0.538692149078545 -1.12532875814501 0.0524041361463807 0.414754774687771 1.40514693475069 0.7235286201491741 2.0 -1.42477226832704 0.0218305298679364 0.801395296813474 0.12396608618659 -0.623376971513567 0.224433155874315 reversed False False False False False False False 0 insufficient_or_context_specific +HYDIN 0.504273631550795 0.139141785376511 0.538692149078545 0.58593749215766 0.0843740258816191 0.464779732481256 0.08604438227512401 1.0 True False False False False False False 0 insufficient_or_context_specific +PNPLA2 -0.645110461344871 0.139209972438878 0.538692149078545 -0.627680164879058 0.151610865260391 0.534332907346501 -0.456150635985163 0.241779052790946 0.805664010597905 0.0296596001318433 0.349513374612741 0.322394422201935 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMED5 0.330525987181745 0.139290840087903 0.538692149078545 0.264118836329294 0.231633079032884 0.601518427890281 0.170669707608579 0.0585270587820523 2.0 -0.0561647962580138 0.901995164796902 0.343378310534528 0.254605832964158 0.287213514276514 0.377187787723855 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM184A -0.940358620736061 0.139336869750994 0.538692149078545 -0.822903320397614 0.203365095476907 0.576835372560841 -1.24229093901313 0.0769494389115005 0.777617812703242 0.191543868522954 -0.464673126309886 0.438233521381342 reversed False False False False False False False 0 insufficient_or_context_specific +UCKL1 -0.494779674656976 0.139392588679919 0.538692149078545 -0.355439902466979 0.294726672018494 0.652324662738756 -0.22927191131686 0.482628211514693 -0.842841739372862 0.0103207893348562 -1.07211365068972 0.0055480039049741 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NGEF -1.00868897830572 0.139465841247032 0.538778028498414 -1.18867093812054 0.0779878560642863 0.457322349441485 -0.18103367749556 0.759455697445548 -0.005673468138512 0.991519250533642 -0.186707145634072 0.711700178196534 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IER3 0.578312764375575 0.139800174306123 0.538942462388233 -0.0188967337055736 0.965348049761753 0.990582362709799 0.735024195637024 0.505053025932994 2.0 -1.02837269825823 0.108510320725145 0.129272510755818 0.836543207084056 -0.899100187502416 0.129091381639453 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ULK3 -0.593125907034154 0.139897169263136 0.538942462388233 -0.344289615204377 0.406591296585846 0.733961461951707 -0.385235141093689 0.270052228690645 -0.513123007880432 0.102234291175216 -0.898358148974121 0.0179377928834325 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AMPD2 -0.492040832047218 0.139946142739317 0.538942462388233 -0.359401515464952 0.285822959932373 0.646864459864731 -0.153755690052015 0.569782955767888 -0.463929420632863 0.0473615227687534 -0.617685110684878 0.0206212459289334 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNTNAP1 -0.493595807844818 0.139951160055929 0.538942462388233 -0.635434582888426 0.0548611097118899 0.420068725637921 1.29347567034117 1.0 0.356130568285403 0.359771530678521 -1.2827164780333 0.0039566153281876 -0.926585909747902 0.0263980859776963 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM155A 0.81257991743261 0.140055561929508 0.538942462388233 1.19078635861057 0.0363405037124558 0.377876708853838 True False False False False False False 0 insufficient_or_context_specific +LSP1 -0.679771440756128 0.140067286843355 0.538942462388233 -0.372305199276314 0.45747678342046 0.76776776876263 1.56699746674125 0.0060569793552522 -0.777906887815344 0.0519126733971142 0.789090578925905 0.112089363219138 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DELE1 -0.271601438745505 0.140141738333405 0.538942462388233 -0.251155351327205 0.171845552799244 0.55281698551323 -0.142030429587185 0.607036030636607 -0.0474128363499022 0.847154638536865 -0.189443265937088 0.419066577415165 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FKBP8 0.411427739804024 0.140160766953309 0.538942462388233 0.340109878812195 0.220167985785703 0.59217704709374 0.2898818592021211 0.0406363524773882 2.0 -0.491593543220724 0.095246136777706 0.391113408747023 0.135734545207948 -0.100480134473701 0.732945190435209 partial_or_other True False False False False False False 0 cross_species_direction_conflict +POR -0.733350678443948 0.140227993319205 0.538942462388233 -0.827325398490434 0.0951436635978324 0.475178240428531 -0.277890188974461 0.653658956001809 0.314596268511614 0.525864157238554 0.0367060795371531 0.950674977155899 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS11 0.428451973096745 0.140239781703221 0.538942462388233 0.328903303299186 0.265465149383641 0.62822323708046 True False False False False False False 0 insufficient_or_context_specific +AGAP9 -0.412746581955892 0.140361031191983 0.538942462388233 -0.407875564874605 0.145554752458447 0.532658823056677 False False False False False False False 0 insufficient_or_context_specific +QSOX2 -0.407090590525669 0.140383043255861 0.538942462388233 -0.0100665752332953 0.971884701236579 0.992040338141303 0.6864165714982379 1.0 0.259621301579397 0.5445306236067 0.141805912830168 0.669823790885404 0.401427214409565 0.271001223412665 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF770 0.536496594850908 0.140457047562364 0.538942462388233 0.168752019379877 0.641726171013981 0.864815393882559 True False False False False False False 0 insufficient_or_context_specific +GEN1 -0.476661844773081 0.140485797783074 0.538942462388233 -0.319234940852224 0.330347794310919 0.678958927844011 False False False False False False False 0 insufficient_or_context_specific +PRR14L -0.186605873377347 0.140597971131783 0.538942462388233 -0.0500388798167784 0.699570082389129 0.889779656651539 0.8060601040354229 1.0 0.322503329539908 0.235582460237373 -0.110972618433404 0.639708278308381 0.211530711106505 0.401510282050849 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF503-AS1 -0.710437501466406 0.140614625626811 0.538942462388233 -0.840285441800092 0.0755623124921836 0.453930920096201 False False False False False False False 0 insufficient_or_context_specific +RHBDD1 0.226324844920662 0.140719879682861 0.538942462388233 0.232784918243941 0.128398093485894 0.511894671487619 -0.0599513476340078 0.890580602344895 0.199080486038488 0.498419188389783 0.139129138404481 0.682575738908159 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TIGD7 0.609531247569871 0.140774741379807 0.538942462388233 1.06593435315952 0.0110600004583898 0.302570357129259 0.0253482844105655 1.0 True False False False False False False 0 insufficient_or_context_specific +COLQ 0.309915013097968 0.140902207979216 0.539197358406872 0.0719670034746702 0.740222790270483 0.908274440555399 True False False False False False False 0 insufficient_or_context_specific +GALNS -0.433197910558289 0.140971971767107 0.539268868810549 -0.478337151494366 0.100471655265458 0.478125555523304 0.21925490658867 0.648517181654085 -0.2902204209079 0.419594932305031 -0.0709655143192295 0.88155061808767 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PXYLP1 0.591778363084079 0.141097231856696 0.539284658628661 0.413576160953681 0.303320406809255 0.66070906851498 -0.271258326474856 0.59444055184476 0.128621802494609 0.755963891346431 -0.142636523980247 0.762158108262382 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ROBO3 -0.58820949996555 0.141216798970474 0.539284658628661 -0.572780687217004 0.153525668934289 0.536502535641712 0.49510086465731 1.0 False False False False False False False 0 insufficient_or_context_specific +TPST2 -0.588760203721676 0.14122949534544 0.539284658628661 -0.623596876464686 0.11887178411759 0.499422322607844 -0.254061996074578 0.403880964912857 0.115954002537413 0.665557838069379 -0.138107993537166 0.630208470085392 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC22A9 -1.05084101604606 0.141231490917622 0.539284658628661 -1.15821272948393 0.10054026380801 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +INTS6-AS1 0.531156171716581 0.141461984111557 0.539969496836521 0.108761500816619 0.755875968484929 0.914440101763119 True False False False False False False 0 insufficient_or_context_specific +FAM204A 0.355767196105422 0.141657837242811 0.53998172024417 0.365615594353783 0.130471671009763 0.515895731524648 0.544605304255453 1.0 -0.539822250369772 0.204968813543712 -0.719915090700216 0.0709685766723886 -1.25973734106999 0.0108240366163341 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EIF3B -0.256697470678357 0.141668751994398 0.53998172024417 -0.240688502107547 0.16871411872494 0.548101773166091 0.3430749652534881 1.0 0.108177248669142 0.758245356647438 -0.15338109131738 0.565298619495715 -0.0452038426482381 0.889633271609508 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRP9 0.400051614570057 0.141669763693536 0.53998172024417 0.50818499396917 0.0584172525697062 0.42715254026823 0.7116892412835211 0.0362078183375138 2.0 -0.0499735317399266 0.902911268270029 0.0820897494988325 0.785539912687646 0.0321162177589059 0.926847030423093 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ESYT2 0.435414308416279 0.141792997695379 0.540123689645298 0.0771280950790694 0.804985325106278 0.93232065187276 0.316981131392965 0.103306580536719 0.127385006914123 3.0 -0.0056644578449701 0.989165574768777 -0.184455421833872 0.504868629952421 -0.190119879678842 0.523063538073943 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF329 -0.323573144287855 0.141930540069435 0.540123689645298 -0.474947215639028 0.0222502345639912 0.346028040476539 0.464209458845546 1.0 False False False False False False False 0 insufficient_or_context_specific +HSPA1A 1.67516063327818 0.141931864238792 0.540123689645298 1.83412386747142 0.109823537596321 0.486170612134991 2.51373705886707 0.188920059523208 2.0 -0.14988629262204 0.901995164796902 -0.642157115781422 0.439157273863523 -0.792043408403462 0.39124284522066 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IFNLR1 -0.913932988825825 0.141962799655778 0.540123689645298 -0.825117114638993 0.190537591943036 0.569976343069084 False False False False False False False 0 insufficient_or_context_specific +SCARF1 -0.414968620237243 0.142137014461527 0.540378202297006 -0.228081323878236 0.427633233583749 0.747680419889399 0.20321894429281 0.747672745172495 -0.585942703822301 0.202952134759072 -0.382723759529491 0.46880710573106 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADK -0.310732858337635 0.142183239816356 0.540378202297006 -0.168570192060343 0.426213809811886 0.746941741270346 -0.516425306804244 0.197634447035345 0.791524400086421 0.038909054860932 0.275099093282176 0.460175901379083 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HPCAL1 -0.742705607479802 0.142690472923155 0.541526244832017 -0.786124070071063 0.119042962477626 0.499743776476652 0.9917695217052099 1.0 0.267701211858733 0.759521321408178 -0.146063397167644 0.817759779332785 0.121637814691089 0.882160573064927 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BIN1 -0.516182602877411 0.142869569055946 0.541649000882252 -0.623532723005522 0.0748395602675047 0.452862231765951 0.652194076529423 1.0 0.0317662506102001 0.923418329475931 -0.373311240149275 0.09815875781029 -0.341544989539075 0.154189898845714 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FILIP1L 0.600409082204224 0.142876725464773 0.541649000882252 -0.0852662486756587 0.85408297061076 0.95526155065304 0.5865705480707161 1.0 1.02597897266106 0.0616863305614072 -1.09703028072463 0.0302254694531734 -0.0710513080635724 0.906222422502304 reversed False False False False False False False 0 insufficient_or_context_specific +TRIM37 -0.264586200022644 0.143106854761879 0.541788979679847 -0.086877611709537 0.631277981580915 0.859914319858038 0.5458948156508769 1.0 0.0711503380579595 0.867994151464597 -0.0631392521273781 0.840269700412269 0.0080110859305813 0.984689765572988 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NRG3 0.909948966355277 0.143113113389545 0.541788979679847 0.838775922576896 0.177820592557608 0.560500608117279 True False False False False False False 0 insufficient_or_context_specific +SUPT3H 0.432166736672608 0.14318535488272 0.541846228262278 0.549062953991572 0.0595030115352619 0.428473540531152 0.0908240628782445 1.0 True False False False False False False 0 insufficient_or_context_specific +STXBP2 -0.795306521922291 0.143406809929712 0.542489824162629 -0.924962365616512 0.0811359710671087 0.461068439742811 -0.235557224091776 0.404232599531047 -0.327469496706224 0.176166305009391 -0.563026720798001 0.0396048276574855 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TKFC -0.893040967308893 0.143597943799323 0.54262288458519 -0.922487593102391 0.130150927069931 0.515512442645691 -0.040156388099657 0.956488298731866 0.558217534113092 0.262553310232916 0.518061146013435 0.322267661503967 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BCAR1 -0.452317245236979 0.143749345973546 0.54262288458519 -0.364817414421994 0.246253454272344 0.611463774743042 0.221414132145825 0.344534065637416 2.0 0.385785273975384 0.151190014579676 -0.204284520018602 0.384937206364341 0.181500753956781 0.471227674791295 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALDH1L1 -1.27867349190156 0.143750351220381 0.54262288458519 -1.46917464283608 0.0923812848903144 0.472460751419842 0.462169181406617 0.536028429344118 2.0 -0.823241625526386 0.0714053681827519 1.01799177702054 0.023070613258961 0.194750151494158 0.660445253520877 reversed False False False False False False False 0 insufficient_or_context_specific +LINC02027 -0.949545121626971 0.143916928733703 0.542863498953353 -1.15980885009798 0.0698769608344563 0.441773025443227 False False False False False False False 0 insufficient_or_context_specific +HOTAIRM1 -0.428337303801164 0.144167053137665 0.543612766795525 -0.12888522565191 0.669074323100409 0.876002815388656 False False False False False False False 0 insufficient_or_context_specific +AL645608.1 -0.965174594428832 0.144335951666765 0.543861162633013 -1.08544016789339 0.0970710784341773 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +MAATS1 -0.524335574272406 0.144622270951298 0.544360389283866 -0.404838408173594 0.261704577859123 0.624330278962413 False False False False False False False 0 insufficient_or_context_specific +MRPL48 -0.35056290624108 0.144637529042558 0.544360389283866 -0.149282941360128 0.545008892917169 0.81520013063734 0.440678201683041 0.571915858226475 2.0 False False False False False False False 0 insufficient_or_context_specific +BCS1L -0.556331773602899 0.144638477427397 0.544360389283866 -0.508288459591649 0.186950746501789 0.56929178900529 -0.0775752209111345 0.883206679897385 -0.0480968043447626 0.90574370919721 -0.125672025255897 0.767577887513157 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM128 0.4129533503316 0.144785406366938 0.544536151420452 -0.0847115562818127 0.787723641436628 0.926576536501901 0.601076686685591 1.0 -0.0009287360111404 0.997620926087684 -0.0210582878504782 0.93926748787036 -0.0219870238616187 0.941142242357347 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC008569.1 0.939513954313506 0.144947982208066 0.544536151420452 0.205467919265371 0.745155681776406 0.909500945159707 True False False False False False False 0 insufficient_or_context_specific +PGAP1 0.442338652001027 0.144958318390779 0.544536151420452 0.5220354468769 0.0800743321985684 0.460059526331928 0.781061801354012 0.0771418282587095 2.0 -0.690617150021559 0.202708482537706 0.275059189314573 0.559075740544916 -0.415557960706986 0.398444622417425 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ACTR3C -0.631301305660064 0.145071406067123 0.544536151420452 -0.906554655980186 0.0336474535524566 0.376543096535729 0.208457162713202 0.386965161488701 2.0 False False False False False False False 0 insufficient_or_context_specific +TTC7A -0.340788604923052 0.145212546247717 0.544536151420452 -0.212390026748347 0.387549687315656 0.721183710367123 False False False False False False False 0 insufficient_or_context_specific +ZNF438 0.244810090574585 0.14521561091283 0.544536151420452 0.243882251505637 0.146217838290441 0.532796338690088 0.206577813179825 0.32542433900241 2.0 True False False False False False False 0 insufficient_or_context_specific +ZNF304 -0.443373097012196 0.145237147414282 0.544536151420452 -0.105962878569726 0.729084018489652 0.904012808833088 False False False False False False False 0 insufficient_or_context_specific +MAN2C1 -0.365433515471442 0.145374333194903 0.544857014508977 -0.50462372338397 0.0333787603400088 0.376280667109215 -0.371194041583899 0.218307662126877 -0.288359389318773 0.277636714907892 -0.659553430902672 0.0318010841651968 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CUL4B 0.39630216938936 0.145540505328816 0.545156956185198 0.394193265761555 0.147491294510932 0.532796338690088 0.0362604568227357 1.0 -0.0935921137885995 0.790661517061766 0.357253333693781 0.154863019710774 0.263661219905181 0.329693421365052 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WDR27 0.234244245990688 0.145586434227473 0.545156956185198 0.153320945260356 0.344670513138264 0.69073818751447 0.392086261143031 1.0 True False False False False False False 0 insufficient_or_context_specific +GANAB -0.327409092620817 0.145781817639293 0.545156956185198 -0.385751447459056 0.084876494793104 0.465302662671366 -0.107545503055802 0.769772313931098 0.267998221365785 0.328878733968837 0.160452718309983 0.594461671378564 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA1191 0.465323552935025 0.145866324041857 0.545156956185198 0.0599873893294448 0.847838754804679 0.952893503643581 0.0335248137081046 1.0 True False False False False False False 0 insufficient_or_context_specific +PRAM1 -0.779908865440968 0.14586743713044 0.545156956185198 -0.600868051343516 0.265941606207631 0.628408079081913 False False False False False False False 0 insufficient_or_context_specific +GOLGA2 -0.321453726513297 0.146246726773543 0.546028060173363 -0.291160215921153 0.190901040441388 0.570164974534704 0.8697068152081421 0.446363535700407 2.0 0.0012142982298135 0.996779540451992 -0.415900146963412 0.051751373041954 -0.414685848733599 0.0640439618877244 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHMP2B 0.413129140567753 0.146307386079792 0.546028060173363 0.207086271675031 0.478019733784849 0.778545319644225 -0.0026755340718771 0.996617940730295 0.480369747571646 0.166359108510039 0.477694213499768 0.212194271702886 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MPDU1 -0.503164422939987 0.146425250378627 0.546092267228673 -0.437419263340429 0.215817265060749 0.587852789707652 0.254752919991469 1.0 -0.390281325869716 0.19521659232482 0.252263523188537 0.33745451514702 -0.138017802681179 0.637951750497701 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALDH8A1 -0.6733189307261 0.146490139631943 0.546092267228673 -0.706864655537733 0.127049166755693 0.508871434979744 0.481213792529509 1.15499714246547 2.0 -0.787966635349454 0.0796349841669779 0.983378802653773 0.0246079859153381 0.195412167304319 0.6531446430029 reversed False False False False False False False 0 insufficient_or_context_specific +ALKBH8 -0.332498246052713 0.146660179623416 0.546092267228673 -0.231310922225831 0.315842997424129 0.668002877965535 0.183472914753381 0.730002914840034 -0.0689816330385861 0.872919594955843 0.114491281714795 0.812320116507902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP2A1 -0.260057652119456 0.146683950090858 0.546092267228673 -0.419092023737567 0.0133787257052131 0.313114831651016 0.357116765702322 0.316899254222641 2.0 0.10475162611169 0.693829216455639 -0.212437366559162 0.300399159688032 -0.107685740447473 0.644128242063037 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS36 -0.483119820849426 0.146742106293237 0.546092267228673 -0.522064730317755 0.116467952659222 0.495128991208452 0.79931958579088 1.0 False False False False False False False 0 insufficient_or_context_specific +PIEZO1 -0.407653095300885 0.146790413775478 0.546092267228673 -0.473637648704851 0.0862726182179388 0.467677448123587 0.424713095805776 1.0 0.339927087895972 0.244737871002347 -0.894596123904297 0.0056542642085908 -0.554669036008325 0.0545506949227302 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM151B -0.297466065654659 0.146841821051544 0.546092267228673 -0.242263830275004 0.241251052299501 0.608572375975566 0.398662262323867 1.0 0.503740704351145 0.435827243641088 -0.330143868544741 0.500457374277587 0.173596835806404 0.79051040585562 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACSL3 -0.278610457565537 0.146971823007129 0.546240754700957 -0.285151461340855 0.13658894410037 0.523136620282319 1.02892713117004 1.0 -0.0874158007120273 0.849675164326135 0.0564142641552747 0.873221488113125 -0.0310015365567526 0.938269467848326 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZC3H7A -0.183868468149904 0.1470134575425 0.546240754700957 -0.245917733239905 0.0482399336761234 0.402912073759924 -0.0569744963044982 0.88898884310209 -0.561736181018101 0.0616215833826196 -0.618710677322599 0.0515106650914961 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RTF1 -0.211465147496595 0.147036960111775 0.546240754700957 -0.187280627433444 0.204281115972343 0.577301933200215 0.3703469416410229 1.0 0.131925234084686 0.688936764998849 0.142406023004988 0.56633130919145 0.274331257089674 0.307330341007821 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TIGAR -0.509253810829113 0.147134618023147 0.546282761861035 0.182351385653932 0.610353089025763 0.848355438906531 -0.0616600288762292 0.901995164796902 0.2806574147093 0.367079897684083 0.21899738583307 0.54811289077523 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACSM5 -0.827174070775991 0.147151749832618 0.546282761861035 -0.81985447342317 0.151324700323469 0.534164555672079 -1.0295915077861 0.009634064843601 0.711147241240407 0.0375662052773244 -0.318444266545689 0.329541339952948 reversed False False False False False False False 0 insufficient_or_context_specific +BEX3 0.360172945636908 0.147252758955353 0.546373375364702 0.1601164624799 0.533033318729632 0.809783322169604 -0.332347376294531 0.374101531665796 0.492942454378025 0.110707249513635 0.160595078083494 0.64503662214377 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MCRS1 -0.575737484040978 0.147306024995053 0.546373375364702 -0.461084716257842 0.255601330890987 0.620376747482078 0.0242604865711369 1.0 0.217250105842795 0.622690304209923 -0.0207822952926271 0.956413063763894 0.196467810550168 0.613116312494816 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR4 -0.460404383703238 0.147331407431645 0.546373375364702 -0.318062737858683 0.317218652152914 0.669290253214092 0.387658662080366 1.0 0.0860713934608487 0.803023879149177 -0.947696656186758 0.004211371776206 -0.861625262725909 0.0103718633793401 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCNN1D -0.716478138508418 0.14744412407199 0.546407533152709 -0.443722999465682 0.385596412828228 0.719960311595735 False False False False False False False 0 insufficient_or_context_specific +SSX2IP 1.0744348296824 0.147512721478471 0.546469934515683 0.896974946123945 0.226128283227817 0.598661588344858 0.262995213207545 1.0 -0.18940786003127 0.683442582720751 -0.191435365531301 0.5914803324301 -0.380843225562571 0.322267661503967 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LONRF3 -0.769087248223386 0.147612824349088 0.546648965092133 -0.766948929652397 0.149262950747522 0.533583468169136 0.690098358531063 1.0 -0.165567184666195 0.743210363848798 -0.392894822820921 0.298712076068866 -0.558462007487116 0.175746193103393 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF682 -0.331139048388761 0.147788841267005 0.546911408125314 -0.149223814044615 0.531242757229557 0.808309703246818 False False False False False False False 0 insufficient_or_context_specific +FAM193A -0.226900193323604 0.147856645919727 0.546911408125314 -0.224022614891492 0.151848203152379 0.534368029741253 -0.0855106306268984 0.796217654277547 -0.248782616051504 0.304212865471568 -0.334293246678403 0.193594134066583 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MEIS1 0.449867232997154 0.147869289431331 0.546911408125314 0.282530690213775 0.363657802759122 0.704883253447919 0.202185557632276 1.0 -0.146707654504336 0.685678336076267 -0.039738345557262 0.904210548761399 -0.186446000061598 0.544931979203416 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C4BPA -0.615268247211889 0.147936545187171 0.546911408125314 -0.67860808336403 0.110168350997681 0.487084359226764 False False False False False False False 0 insufficient_or_context_specific +SEC61A2 -0.331095619162524 0.147980466894244 0.546911408125314 -0.306999249549775 0.181034698684699 0.563603217043398 0.3743647004808859 0.255335567472906 2.0 0.110686677646918 0.730708557619437 -0.440847271022378 0.0799696695885266 -0.33016059337546 0.208743386018199 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMC6 -0.696337360866945 0.148146534065601 0.546911408125314 -0.684790943124259 0.155834669397413 0.539558215777 -0.348753366887737 0.249314436019167 -0.454441937686436 0.0955321082711878 -0.803195304574173 0.0158491188301678 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PUF60 -0.780513933013672 0.148149898393483 0.546911408125314 -0.844113231294096 0.114137303344018 0.4924007041452 0.5650577787776371 1.0 -0.181037526486708 0.481635188988784 0.296298399850737 0.166512396272579 0.115260873364029 0.625684793517683 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB35 -0.463166433666162 0.148315633525841 0.547140621511472 -0.640569043518361 0.0391487139088238 0.379484931484566 0.248522416558647 1.0 -0.224515924052659 0.42564063301188 0.375770374673424 0.107640497622777 0.151254450620765 0.554073851158209 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CALCB -0.750716792043434 0.148486406597457 0.547280172215329 -0.881515628415505 0.0832812966538881 0.464737806591834 False False False False False False False 0 insufficient_or_context_specific +LINC00310 -0.598023850587246 0.148504063814458 0.547280172215329 -0.495254278720165 0.236045440490755 0.604926482992162 False False False False False False False 0 insufficient_or_context_specific +GIT1 -0.41804251805383 0.148508968876389 0.547280172215329 -0.111204623271174 0.723680905063373 0.902293693393847 0.155744899561881 0.629960627311125 -0.482897990543801 0.0678806956385509 -0.32715309098192 0.232540943069795 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SKP1 0.304049090455881 0.148603751035978 0.547353721974613 0.384499169955146 0.0674222322100195 0.43786261079484 0.40786693936396 0.0422765286366976 2.0 True False False False False False False 0 insufficient_or_context_specific +RBM12B 0.372174873127098 0.148632612322525 0.547353721974613 0.524187061842532 0.0366366997953403 0.377876708853838 0.484766250703281 0.0299371679564671 2.0 True False False False False False False 0 insufficient_or_context_specific +SERINC5 -0.302296395198955 0.148847710979924 0.547689432491821 -0.365891152410754 0.0814576109015448 0.461068439742811 0.47956753407327 1.0 -0.471146006818759 0.0348629057294948 0.403412045801213 0.044832639827498 -0.0677339610175464 0.756055771634903 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NSD2 -0.35222919678416 0.148892618721185 0.547689432491821 -0.12876074285094 0.609307537341601 0.848013066172034 0.516546536515828 0.126894114413948 -0.817470394886125 0.0156238242846543 -0.300923858370297 0.343744562407399 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RRP1 -0.658705342682643 0.148931271138854 0.547689432491821 -0.391910963728152 0.414744061424693 0.736925521999492 False False False False False False False 0 insufficient_or_context_specific +AC100793.2 -0.519648175018506 0.149033240644651 0.547740686939544 -0.492849497520586 0.172663213648731 0.553858965567902 False False False False False False False 0 insufficient_or_context_specific +MIR29B2CHG 0.349545816094238 0.149075722594523 0.547740686939544 -0.0168748415462357 0.943103716733069 0.984366565940656 0.481521846528471 0.6278008214742471 0.0576341924742154 3.0 False False False False False False False 0 insufficient_or_context_specific +BICD2 -0.328529996095048 0.149100846208018 0.547740686939544 -0.129413560382747 0.578241573930347 0.831066884479525 -0.015743949885799 0.964510570781438 -0.0922671188516835 0.717651886690865 -0.108011068737482 0.694164662882171 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF14 0.406727898301174 0.149249710927266 0.548096851467851 0.431680800126431 0.127131697079953 0.50900889562766 0.0265503235923631 1.0 True False False False False False False 0 insufficient_or_context_specific +LINC00882 -0.563151225436632 0.149488115318828 0.54848515087022 -0.130384182591511 0.73224576890372 0.904431845923655 0.624403048467986 1.0 False False False False False False False 0 insufficient_or_context_specific +PLD2 -0.394841852607305 0.149635153295739 0.54848515087022 -0.343231242593915 0.213260854662386 0.586184416554478 0.348251942266702 0.388449867068896 -0.747040972480758 0.0402823430447534 -0.398789030214056 0.284626592745876 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLYR1 -0.214011925115285 0.149677405179665 0.54848515087022 -0.17934281334874 0.230125075792845 0.601252301465197 -0.0895901715960642 0.72189463408318 -0.0562517862366683 0.787912172201962 -0.145841957832732 0.48225604220515 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAH6 0.830198978480839 0.149696959776358 0.54848515087022 0.56226464595483 0.329671565822318 0.678186271926176 True False False False False False False 0 insufficient_or_context_specific +A1BG-AS1 0.82446283394507 0.149704557478048 0.54848515087022 0.79868404106224 0.162947623534515 0.544298760692042 0.0362507062465469 1.0 True False False False False False False 0 insufficient_or_context_specific +AC074386.1 0.382351484862198 0.149748691938989 0.54848515087022 0.645353735768715 0.0098351701465901 0.301445445011239 0.0446541499843511 1.0 True False False False False False False 0 insufficient_or_context_specific +HSP90B1 -0.480579180548535 0.149810210765776 0.54848515087022 -0.287983800502531 0.390369114826839 0.722218665388488 0.0158498677849619 1.0 -0.500315989856416 0.194875180701346 0.150706408011763 0.674403513331964 -0.349609581844653 0.325978709915503 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC022217.3 1.06507535147527 0.149822994422212 0.54848515087022 0.0129706392888092 0.9831617634183 0.99451887511202 True False False False False False False 0 insufficient_or_context_specific +TRAF5 0.385346262884605 0.149927742949108 0.548678374369735 0.269118836558691 0.323877360318835 0.673780634605742 -0.332086942119736 0.459992657549225 -0.520356831956334 0.170682207017454 -0.85244377407607 0.0485708038157639 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SEMA4D -0.430312915944456 0.15006235656 0.548818289698239 -0.394359972156279 0.188849264647785 0.569351952070621 -0.0704786794714576 0.915993062050496 -0.232806585185793 0.596533987372648 -0.303285264657251 0.541591120424982 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IMMP1L 0.295822756460412 0.150345601116427 0.549496236668308 0.268181125074275 0.193168194357753 0.570885363891703 -0.0408632306668685 0.911205409548353 -0.0401077699711417 0.886486395166066 -0.0809710006380102 0.77967450345531 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TENT4A -0.237646906000544 0.15050457050402 0.549836420547214 -0.143217972348532 0.399616967510128 0.729679668746226 0.00274759892415649 1.0 0.190320962862615 0.522045968767996 -0.438866281530205 0.0789040932881835 -0.24854531866759 0.337912240642448 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPATCH2L 0.187156310564813 0.150560936431465 0.549852081232586 0.284122028290181 0.0256945718227356 0.351427309358494 -0.37560553430159 0.196752049273969 -0.0022180453175269 0.995055111246838 -0.377823579619117 0.162021367298197 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NELFCD 0.289758986564979 0.150791026993967 0.550357757273381 0.372519150504568 0.0606889224473551 0.429268745755419 0.0416966213262369 1.0 -0.560677099085666 0.0597335364523075 0.260680812739229 0.301309820869809 -0.299996286346437 0.26243986758422 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SDAD1 -0.302878387216802 0.151030344126037 0.550531585105462 -0.110168990562466 0.619255067693557 0.853648649263425 -0.107132897227042 0.779825758885875 -0.172844805218344 0.540099439766252 -0.279977702445387 0.355942804915087 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C2ORF72 -0.531985445214814 0.151058262893956 0.550531585105462 -0.629602316944599 0.0879736427346615 0.468622105620855 False False False False False False False 0 insufficient_or_context_specific +PGGHG -0.725803311552263 0.151135135136213 0.550531585105462 -0.812849823186239 0.105304198008039 0.482830329046451 -0.0896793630275632 0.805549655367754 -0.297504423033347 0.255422865493133 -0.38718378606091 0.167727358822497 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCNH 0.446946954248232 0.151204490051266 0.550531585105462 0.452846401488671 0.145626617014525 0.532658823056677 0.164180763894168 0.17783210368066 2.0 -0.202447277320611 0.548600138356448 -0.177019837896259 0.517761512683316 -0.37946711521687 0.194430369285587 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PURB -0.301938111235155 0.151407972325891 0.550809250413692 -0.157226361400571 0.46384179246448 0.769643508539993 0.618749773441543 1.0 -0.102602781731607 0.736015393349425 -0.325591538407435 0.166359108510039 -0.428194320139042 0.089461808039826 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RALBP1 0.353414779940697 0.151482894553225 0.550809250413692 0.11085645750046 0.642163272952055 0.864901114405893 -0.137185987371578 0.674738380986663 0.028015865829687 0.924453884611884 -0.109170121541891 0.705629335796316 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RBM5 -0.22457860719741 0.151777042388415 0.550809250413692 -0.196683402612935 0.210724679936667 0.582874291530346 0.258686444829277 0.373669799933845 -0.217165970295161 0.382282246527818 0.041520474534116 0.892828755240047 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHID1 -0.46178694371057 0.151823155088743 0.550809250413692 -0.456477914908454 0.156941395041221 0.540087108489313 0.457437075275755 1.0 -0.149063957470727 0.607863110977287 0.0988042926475928 0.680847816824711 -0.0502596648231338 0.857234275776447 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBRSL1 -0.398931293449724 0.151951505120395 0.550809250413692 -0.460997340439194 0.0909818750192865 0.472234212482528 -0.488868633328 0.0729089194565824 -0.0961075490763665 0.701790149189709 -0.584976182404367 0.0328447699088656 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKRD44 0.212415230177418 0.151961271394216 0.550809250413692 0.133258871028772 0.365042302817817 0.706387878106228 -0.154789209419511 0.770671448719166 0.547986488083764 0.14981553963058 0.393197278664253 0.336025599851686 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC139887.2 -0.327998377374903 0.152052575457486 0.550809250413692 -0.326725339109597 0.153454630172248 0.536502535641712 False False False False False False False 0 insufficient_or_context_specific +MARVELD1 0.499178561637123 0.15220570625846 0.550809250413692 0.687962439165051 0.0499832841611024 0.40534943521819 0.347577882904166 1.0 -0.0487403918139667 0.869015643979454 -0.245478317440859 0.235521320880196 -0.294218709254825 0.179449433518414 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ACSM2B -1.22851110046402 0.152268230992193 0.550809250413692 -1.39024204437214 0.104436566729461 0.480872774326057 False False False False False False False 0 insufficient_or_context_specific +PARM1 0.706233308429864 0.15227850363001 0.550809250413692 0.936369239653085 0.0572971055640245 0.424455207563489 0.0666886009613417 1.0 -2.10407105153495 0.0055830573429901 1.27862838427756 0.0429621316207372 -0.825442667257388 0.124027214028329 reversed True False False False False False False 0 cross_species_direction_conflict +MFSD8 0.301453714359173 0.152307714833227 0.550809250413692 0.143440615786249 0.510120095444305 0.796519013040946 -0.0606011173550305 0.883360367629338 0.120524779355749 0.670947694510945 0.059923662000718 0.861071568106089 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM117A -0.452395407446025 0.15238976663863 0.550809250413692 -0.57022077774726 0.0668898389610605 0.436862290339161 0.7251458260811031 1.0 -0.27001742826883 0.486110924452864 -0.0135652690532954 0.970274055481067 -0.283582697322125 0.403905390011141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITGB3BP 0.521461496986952 0.152395701720367 0.550809250413692 0.289688350393603 0.434936971991854 0.75243712029294 -0.0452730432730541 0.967105488022043 0.489620307110279 0.44159364784911 0.444347263837225 0.570260122417691 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FO393400.1 -0.498710738283629 0.152416897147841 0.550809250413692 -0.705194514428283 0.0332523973966023 0.376280667109215 False False False False False False False 0 insufficient_or_context_specific +ISM1 0.873852219684854 0.152481465701159 0.550809250413692 1.31291837916675 0.0420883017187359 0.3908928278867 0.0194199698090067 1.0 True False False False False False False 0 insufficient_or_context_specific +PLPPR2 -0.495833170643018 0.15253217186957 0.550809250413692 -0.577014652996596 0.0894449463086552 0.470746198832535 0.9437305593381301 1.0 0.432894629279347 0.185346015018113 -0.682928204895508 0.0273601818699855 -0.250033575616161 0.421375030668737 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HLF -0.648120208431245 0.152596374384929 0.550809250413692 -0.600197076435504 0.187185064224144 0.56929178900529 1.23366651645613 1.0 -0.471507238973995 0.314672093652591 0.795457796659671 0.0558771163161351 0.323950557685676 0.439454767522404 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RUSC1 -0.610526583245299 0.152613211011205 0.550809250413692 -0.560404478478258 0.19257909312681 0.570885363891703 -0.147391746843169 0.759200471099567 -0.368000946393496 0.298123821774826 -0.515392693236666 0.185853928434108 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PROSER3 -0.380843342434243 0.152727690693361 0.550809250413692 -0.397348895095807 0.133335736557654 0.519659913833781 0.493921937216001 1.0 0.0560136113821673 0.932558334579471 -1.05692724721421 0.0312492702924022 -1.00091363583204 0.0556752012051446 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GUSB -0.426219092556671 0.152753313621073 0.550809250413692 -0.522610532710576 0.0708465611913725 0.443801226075734 0.342714942768072 1.0 0.166972425921454 0.617704561534471 -0.224761290046311 0.389145166964693 -0.0577888641248575 0.858029951144203 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR45B -0.254081323420244 0.153094597255863 0.551229450649633 -0.309324350446493 0.079654190002227 0.459160525051927 0.310308205066012 1.0 -0.56215053143741 0.193783979845012 0.226302885038062 0.554413349253297 -0.335847646399348 0.398065229205286 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA1549 -0.59208390388007 0.153180485672982 0.551229450649633 -0.613462123297662 0.138432066451782 0.523810858054217 False False False False False False False 0 insufficient_or_context_specific +TOP1MT -0.582270866430226 0.153183103637623 0.551229450649633 -0.671331201478841 0.0982363625794883 0.478125555523304 -0.312486537071356 0.53076631407381 0.036486006134131 0.937182186482171 -0.276000530937225 0.533335368241833 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAST 0.231366130430813 0.153320025621706 0.551534184161488 0.310360018494192 0.0552984356522465 0.421331649096072 0.111022858792036 1.0 -0.374942669639707 0.175144956637759 0.464461093572044 0.0627653520186576 0.0895184239323372 0.745871257998719 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ADAM32 0.655043629467137 0.153637944567845 0.552167465823386 0.891214100049992 0.0499915753552063 0.40534943521819 0.862520167030015 0.0372949391241219 2.0 True False False False False False False 0 insufficient_or_context_specific +USP1 0.40890782820305 0.153781133938802 0.552167465823386 0.315110345656463 0.276407760664145 0.6396696093258 -0.0400776370334838 0.957440974715565 0.266245273054233 0.579664654921092 0.226167636020749 0.692860349728178 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SMAD3 -0.27044260764128 0.153797660454625 0.552167465823386 -0.0508572733304915 0.806751889440267 0.932788199072101 1.19875932676387 0.710373921960698 2.0 0.0739367985269042 0.843136433162649 0.0534892127195729 0.85242134317132 0.127426011246477 0.666224048173032 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DCAF8 -0.529256394855123 0.1542477929715 0.553338875074631 -0.325207599656052 0.391311570206446 0.723042974840681 -0.252930242593828 0.348346249395982 0.319414166907316 0.170682207017454 0.0664839243134874 0.806497726527629 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM124A -0.543294281144724 0.154252643470545 0.553338875074631 -0.45073455935108 0.243370277286487 0.609898739043611 0.677836160116927 1.0 -0.393113197329925 0.469429538722698 0.57493110453762 0.170278715961794 0.181817907207695 0.713208610533296 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLIN1 -0.956082334317217 0.154293393466538 0.553338875074631 -1.32517389859538 0.0389604686296973 0.379484931484566 False False False False False False False 0 insufficient_or_context_specific +DHTKD1 -0.568080057929194 0.154396730895462 0.553521454938639 -0.810390001455316 0.0352703876556868 0.37720666979567 0.4075067612032721 1.0 -0.8105302786191 0.0371541990968827 0.44315492237359 0.181346342106623 -0.36737535624551 0.284207157375764 reversed False False False False False False False 0 insufficient_or_context_specific +FTSJ3 -0.570632129433188 0.154489486183787 0.553665986126416 -0.421947468555541 0.310887202247648 0.66386306487225 0.298365627933263 0.430563612885458 -0.376739835755296 0.214976534815621 -0.0783742078220331 0.840937704539414 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C12ORF73 0.401376707008056 0.154550600901726 0.553697062884433 0.361868602662463 0.197712623535514 0.572531508307175 True False False False False False False 0 insufficient_or_context_specific +C15ORF41 0.360090331953968 0.154606268992053 0.553708611946438 0.313474521713262 0.220256270231867 0.59217704709374 0.564206045078298 1.0 True False False False False False False 0 insufficient_or_context_specific +AC012435.2 -0.411014215438072 0.154714356584095 0.553720059937247 -0.410043699983168 0.155950098488719 0.539558215777 False False False False False False False 0 insufficient_or_context_specific +DNMT1 -0.489015751330438 0.155075814331392 0.554449863769332 -0.498794197407801 0.146606029109124 0.532796338690088 0.7968468544234221 1.0 0.499470352028539 0.132105171025321 -0.675088375245239 0.0297827090668634 -0.1756180232167 0.591382357098414 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SAP30BP -0.321519724806474 0.155389318228258 0.555097569014293 -0.378568368620872 0.0900070615116614 0.471142565909827 1.31362298843759 1.0 -0.133489746049372 0.729927818767969 0.162012652714538 0.572684977016586 0.0285229066651658 0.937318731862961 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZDHHC17 0.322056731418647 0.155611869431691 0.555097569014293 0.352594188106937 0.117801487656245 0.497300322540835 0.118551706876398 0.0535012076806808 2.0 -0.284841909230306 0.429163567942419 -0.099474487857495 0.759301436136173 -0.384316397087801 0.229611898048009 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HGFAC -0.975772317075544 0.155623996462869 0.555097569014293 -0.765149427709937 0.2727669331 0.636858310409067 -2.07393724936614 7.0959212983016e-05 1.63240519470833 0.0005785430584826 -0.441532054657811 0.111010998081844 reversed False False False False False False False 0 insufficient_or_context_specific +AP3S1 0.47000399473232 0.155661134873468 0.555097569014293 0.755150604259601 0.0206554914194085 0.333389311130767 0.0745812224969396 0.135803095139018 2.0 True False False False False False False 0 insufficient_or_context_specific +TVP23A -0.915199544601676 0.155719592153014 0.555097569014293 -0.512370705555174 0.449796644892428 0.763939182518913 1.2476087410936 0.12886851016854 -1.10774933063616 0.0840730523831337 0.139859410457438 0.887575995081015 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC9 -0.572408458643286 0.155744889546911 0.555097569014293 -0.602167321019334 0.133112916819338 0.519212049578983 0.355599533979877 1.0 -0.332483446716485 0.21861745462388 -0.372832934900317 0.123466853468569 -0.705316381616802 0.0168263090542282 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASNS 0.469377578025192 0.155781852738734 0.555097569014293 0.650723294594966 0.0549310211844084 0.420068725637921 True False False False False False False 0 insufficient_or_context_specific +MB21D2 0.339633956993948 0.155782733187095 0.555097569014293 0.238376306114538 0.321188272442495 0.672472248121257 0.741291747700754 0.500883185782402 0.0840562899433689 3.0 -1.21126987711622 0.0372199297055223 1.37696176573649 0.0119325691705398 0.165691888620268 0.749175970916833 reversed True False False False False False False 0 cross_species_direction_conflict +PPA2 0.321351515077973 0.155861690134307 0.555191539958842 0.282688083621693 0.216999625224893 0.588712555412956 0.0572144196218334 1.0 -0.62831814687022 0.061479475912415 1.06795531940615 0.0036707134459979 0.439637172535932 0.135275628399412 reversed True False False False False False False 0 cross_species_direction_conflict +VIPR1 -0.877246260928999 0.156042812498436 0.555489866653481 -0.795041134741148 0.202631137015659 0.57668584531318 -1.45665089811901 0.0120352310710462 0.901654418186207 0.0650047922411513 -0.554996479932805 0.249587519536909 reversed False False False False False False False 0 insufficient_or_context_specific +LINC01818 -1.18150086185848 0.156050667218623 0.555489866653481 -1.07131336714075 0.201406207954874 0.576216193866676 False False False False False False False 0 insufficient_or_context_specific +R3HDM2 -0.189339588818072 0.156213282526721 0.555695764595907 -0.250900230566997 0.0544766234902358 0.419107768280135 0.401920839657508 1.0 -0.12988997857243 0.689319692062457 0.0867641923225161 0.748707805050103 -0.0431257862499142 0.890067727317474 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WBP2 0.351994023695695 0.156213774324745 0.555695764595907 0.0936908952597514 0.709443217021922 0.894364356455815 0.5979773544363399 0.386021878773706 2.0 -0.433487948144505 0.0975242624025484 0.471171292614043 0.0502135060867582 0.0376833444695378 0.893105727313485 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KLB -0.903812516092568 0.156409578110154 0.556076040614174 -0.895460442001012 0.16165806935882 0.543541307772207 -0.773329457494682 0.268743912777657 1.18554400631867 0.0473615227687534 0.41221454882399 0.495926037375165 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXW5 -0.43560918174699 0.156426012561479 0.556076040614174 -0.451759562362023 0.140228568823956 0.525724762599689 -0.0640863573212368 0.83289069999139 -0.344341100046775 0.116184725286477 -0.408427457368012 0.0835114949080359 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CPN1 -0.646666748606607 0.156731703484163 0.556917240378512 -0.677298688112225 0.138096626839936 0.523810858054217 -0.587772748750553 0.108819388266671 0.798451156600627 0.0253744316437154 0.210678407850075 0.543980115418851 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NAPEPLD 0.444544882434472 0.157003340988499 0.557330824147538 0.238468555257434 0.437750264855059 0.754574252463627 0.113074923654147 0.120162714641352 2.0 True False False False False False False 0 insufficient_or_context_specific +GOT2 -0.354086345407803 0.15711184585264 0.557330824147538 -0.328763696268155 0.189794294816473 0.569886897607216 -0.103828788457477 0.846663403416856 0.252729749246952 0.512399002581321 0.148900960789476 0.731195778928087 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DBH-AS1 -0.692057383697464 0.157148500046147 0.557330824147538 -0.685908767875313 0.161349363401547 0.543541307772207 0.18169808654469 1.0 False False False False False False False 0 insufficient_or_context_specific +ACLY -0.46893463100453 0.157502610569307 0.55818180340625 -0.395648826395616 0.239800599691038 0.606713331305531 0.236606120531102 0.524699804380088 -0.131701990805174 0.680696273329908 0.104904129725929 0.76790063398935 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARPC5L -0.472903157359684 0.157553482037355 0.55818180340625 -0.446989378771852 0.18334300210337 0.565541146173142 0.102305078662633 0.784039873542692 0.219564117930389 0.416179992973872 0.321869196593022 0.266470793772336 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C6ORF89 0.232928549162139 0.157652788194491 0.55818180340625 0.0216893184408372 0.886917272020341 0.963622568156774 0.469353961231384 1.0 True False False False False False False 0 insufficient_or_context_specific +SLC44A3 -0.38924556153752 0.157843665580175 0.558543139130469 -0.0460295192763135 0.877159813387092 0.960989240400635 0.251016053275441 1.0 0.64832051521081 0.303658701050419 0.0932820560425908 0.854803826069206 0.741602571253401 0.192998143472571 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOL9 -0.281282607863369 0.157860648528634 0.558543139130469 -0.320387252233505 0.101102490674658 0.478335084675213 0.478189539311483 0.140288315251886 -0.689309772731813 0.0234257198855671 -0.21112023342033 0.504928463998548 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MARK2 -0.236894133308402 0.158026308499263 0.558628412442854 -0.152222051495977 0.376675876237348 0.714121727655579 0.22221970824507 0.48851729371843 -0.561844416304596 0.0448205329172076 -0.339624708059526 0.231990552597079 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTP4A1 0.526493493040113 0.1580434805803 0.558628412442854 0.79450991234025 0.0243078504956935 0.349408136686844 0.546119757442358 1.0 True False False False False False False 0 insufficient_or_context_specific +ZFYVE26 0.348689729436976 0.158223031857964 0.559046052862096 -0.0554706913930532 0.814386733008026 0.935614268454704 0.8828287950722141 1.0 0.0146874476238375 0.971220331487005 -0.226379331275569 0.418126590674299 -0.211691883651732 0.489499409794285 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF135 0.425198887287599 0.158267536655125 0.559046052862096 0.0801834812286326 0.798410429422644 0.92925379048471 True False False False False False False 0 insufficient_or_context_specific +AL137145.2 0.634860983745332 0.158479611763098 0.559420842860178 0.82391103183534 0.0694135290431591 0.441118118691429 0.0327536882273912 1.0 True False False False False False False 0 insufficient_or_context_specific +KIAA1324L 0.613443477076084 0.158636601698065 0.55964247475747 0.81279929281466 0.0572522271887169 0.424455207563489 0.271402142198671 0.147288734542358 2.0 True False False False False False False 0 insufficient_or_context_specific +MBTPS2 0.374410068450183 0.158648411342026 0.55964247475747 0.184636626379738 0.502923988787001 0.79229878349175 0.0412968696816182 1.0 -0.0384368066499453 0.944522201230397 0.101931342692543 0.785719900084117 0.063494536042598 0.889065524481604 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DBH -1.07924647490972 0.158957303879687 0.560190281865661 -0.874361890028907 0.259894496396739 0.622885940784012 False False False False False False False 0 insufficient_or_context_specific +SERBP1 -0.218187926025742 0.158962879756537 0.560190281865661 -0.283289249830798 0.0619458857860547 0.431813959784778 0.136874033967457 0.742908609411722 0.17279464536928 0.58894060852306 0.309668679336737 0.350573258198718 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF273 0.332043610380533 0.159171700306445 0.560617732561358 -0.141153373711852 0.56252666039467 0.823624529253491 False False False False False False False 0 insufficient_or_context_specific +BRAP -0.26288073095887 0.159443090163788 0.561320488812696 -0.124992255348779 0.527063434777736 0.804819865166353 0.462415432447556 1.0 -0.59563137019033 0.151302546427237 0.316835135625778 0.381944116760868 -0.278796234564552 0.4676484286314 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EML3 -0.436944305439568 0.159501463115421 0.561338815857538 -0.496266027368252 0.106938720452528 0.483261130274234 0.325684168773607 1.0 -0.137184218836839 0.637583416884336 -0.289019015174496 0.208589517138224 -0.426203234011334 0.0902152795662237 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC41 -0.274169625536513 0.159565030203448 0.561375404494503 -0.447695458283147 0.0160446800873574 0.322306608081226 0.38478899565653 1.0 0.0610748773678048 0.873026380943741 0.0659410954621188 0.816948466455774 0.127015972829924 0.67258129263617 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRKG1 0.395278276098113 0.159692210279732 0.561378161509638 0.594508704178056 0.0303430252733026 0.374622380904833 0.411506465147193 0.148224057464056 0.132311996525171 3.0 -0.0380252993063559 0.936257534403958 0.163799277248976 0.598363604307341 0.12577397794262 0.731195778928087 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SIPA1L1 0.337423446614945 0.159855165126211 0.561378161509638 -0.0203844970724291 0.931119782613516 0.980624704721547 0.0995284905476163 1.0 0.336610826778705 0.313267332152462 -0.648810371124479 0.0359083847684528 -0.312199544345774 0.311734520450992 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC40 -0.447199483549051 0.159859326082834 0.561378161509638 -0.521430974050147 0.100847985474798 0.478335084675213 False False False False False False False 0 insufficient_or_context_specific +CSRNP3 -0.500321512044473 0.159884839141834 0.561378161509638 -0.331664216806582 0.352610450773775 0.696643177258517 1.13188837455154 1.0 False False False False False False False 0 insufficient_or_context_specific +TBX18 0.736202521656977 0.159997207780007 0.5615482314554 1.02666924053958 0.0483672707922712 0.403191887129892 True False False False False False False 0 insufficient_or_context_specific +AC119674.2 -0.592073550020143 0.160039650355114 0.5615482314554 -0.594833181222134 0.158048971809066 0.541917271337019 False False False False False False False 0 insufficient_or_context_specific +ALDH1A3 0.967624384897959 0.160186410306602 0.561876451832925 0.859660790445957 0.210244841200924 0.582800422305635 0.0715066611513868 1.0 -0.218784804499632 0.87858042675872 0.947661178428621 0.24192246749082 0.72887637392899 0.443529638632892 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EXOC3L2 -0.594575708493245 0.160256762925608 0.561936533699294 -0.369700163874904 0.397381354113442 0.728024800638387 0.467361180399705 0.259736012744498 0.0437226773638401 0.907255086556375 0.511083857763545 0.178994249633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC087477.2 0.4475043978227 0.160484050549754 0.562272694701784 0.406120724383818 0.202581306434685 0.57668584531318 0.162051383455901 0.0859977465201556 2.0 True False False False False False False 0 insufficient_or_context_specific +SIGLEC9 -0.714984547511193 0.160537262992706 0.562272694701784 -0.834116795981022 0.0992175375036069 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +BRINP2 -0.968349257282557 0.160557591454823 0.562272694701784 -0.90878727260324 0.190377677712185 0.569920796826702 0.7952941765234051 1.0 False False False False False False False 0 insufficient_or_context_specific +RAD9A 0.262082544979732 0.160565653961534 0.562272694701784 -0.0536180194530121 0.768296157428835 0.919690570309936 0.5691999798977609 0.0782082732281729 2.0 0.555549241477369 0.133086958437545 -1.11019497976745 0.0055040065855936 -0.554645738290077 0.134036993180511 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MT-ND3 -0.396412660531674 0.16066316029422 0.562427601586995 -0.306223199556578 0.283422430064494 0.644213997119682 -0.455026792731858 0.46104734065596 0.522920564417184 0.311406616063649 0.0678937716853255 0.915632744476247 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCP1 0.370258437067123 0.160780009945755 0.562650097781664 0.329803340151055 0.215620935353518 0.587852789707652 -0.0869733210091275 0.83289069999139 0.146427015037726 0.627442103374478 0.0594536940285989 0.867142307856678 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC007376.2 0.494304625851705 0.160881354384915 0.562729582907044 0.669786342017795 0.0537030445237428 0.417523375612427 0.0314708927493663 1.0 True False False False False False False 0 insufficient_or_context_specific +AC011476.3 1.02815722870181 0.160936196129369 0.562729582907044 0.518324891209994 0.458229320087237 0.768056066277353 True False False False False False False 0 insufficient_or_context_specific +AC005670.2 0.357907389060134 0.161006890653342 0.562729582907044 0.188055660326507 0.442955279929138 0.758961675672158 True False False False False False False 0 insufficient_or_context_specific +HNRNPUL1 -0.217992036721073 0.161066362090974 0.562729582907044 -0.312818009258062 0.0393403501145005 0.379484931484566 0.535147363213354 0.7022059243612321 2.0 0.0297149771311428 0.924878785943647 -0.163264537777527 0.445278872853063 -0.133549560646385 0.565888059038065 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RABGAP1L 0.218623215213159 0.161069217611772 0.562729582907044 0.253467205664063 0.0995918584616628 0.478125555523304 -0.362543564308092 0.191346521738403 0.0600184126967413 0.821587172464004 -0.30252515161135 0.235650343826831 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRR12 -0.41966091885459 0.161310428175809 0.563382941610158 -0.38844784407625 0.197385994981384 0.572466025511161 -0.247518794386017 0.327469324705013 0.0421070021850542 0.865490092598848 -0.205411792200963 0.37305938205724 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PITPNA -0.276289527995124 0.161366907295375 0.563382941610158 -0.152442600679341 0.441175561622793 0.757633633639143 0.501788092277342 1.0 -0.255924243528558 0.268624354862104 0.294442376076557 0.146810980276726 0.0385181325479989 0.875787911848911 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HTATSF1 -0.538041699492814 0.161425024957497 0.563382941610158 -0.524452591989755 0.174257467875229 0.556001917747557 -0.282325135993523 0.446002764295964 0.164519784289339 0.596936347408175 -0.117805351704184 0.739076452782188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COQ4 -0.356833116870551 0.161469670516418 0.563382941610158 -0.35781930943629 0.160292214035535 0.543541307772207 -0.0204176163709809 0.981117342485003 0.301592845711514 0.578981983897481 0.281175229340533 0.663819059851599 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP001043.1 -0.745936805172728 0.161661538794028 0.563502444760982 -0.69840086508704 0.190751239813495 0.570066802692612 False False False False False False False 0 insufficient_or_context_specific +DNHD1 -0.350123360555577 0.16182921507615 0.563502444760982 -0.404066734391282 0.106829847862829 0.483261130274234 0.372483841165107 0.566693700192947 -0.571683200772846 0.24575969610965 -0.199199359607739 0.754289850217163 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ODR4 0.230887867535325 0.161845638086253 0.563502444760982 0.121545722204796 0.47158174082476 0.774962086083438 -0.0413694921950613 0.917945009132389 -0.340871756142236 0.203955843125764 -0.382241248337297 0.184799412435821 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LMF2 -0.507439090066606 0.161890355399206 0.563502444760982 -0.537428415062218 0.136771105518806 0.523136620282319 0.387182054161807 0.25213261337738 -0.208983208391165 0.45866253403565 0.178198845770642 0.584856931164536 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FUT8 0.291914743313794 0.161932265083217 0.563502444760982 0.35052930769926 0.0941788297803324 0.474102577239623 -0.246248425930963 0.538493466925763 0.237317139338275 0.458534415792017 -0.0089312865926882 0.984209090115451 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF546 0.508275218073552 0.161990082993961 0.563502444760982 0.504268961268196 0.166101830736091 0.54581485493671 0.0268603313498868 1.0 True False False False False False False 0 insufficient_or_context_specific +CTGF 0.617602269220551 0.162035612591268 0.563502444760982 0.1361096615251 0.771191604066642 0.920641521976153 True False False False False False False 0 insufficient_or_context_specific +CLCN7 -0.534221661384648 0.162192969418033 0.563856888744021 -0.5415964380724 0.156470038902641 0.539558215777 1.05760399485511 1.0 -0.0406654912608147 0.923269418503395 0.128441474566752 0.658267297256356 0.0877759833059369 0.792100260068846 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPHX2 -0.621354689725374 0.162261432033885 0.563879554523921 -0.79180223737723 0.0724972679715932 0.449108979935905 -0.852215197814384 0.153710885039634 1.48792344705466 0.0147483277939367 0.63570824924028 0.240720343589213 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERI3 0.243838833979728 0.162432182263293 0.563945735066046 0.264607094884633 0.128014140318384 0.511104106212365 -0.023131417784288 0.947769372817625 -0.227742089938745 0.328938777055768 -0.250873507723033 0.310905241900575 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SYNE1 -0.304874499868783 0.162734750333477 0.564624874801464 -0.252511308964931 0.244213016805332 0.610669341516615 0.423520233706455 1.0 -0.077927761359186 0.84605934656501 -0.292346233939935 0.29668785816451 -0.370273995299121 0.21622901178035 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFASC 0.451744664050288 0.162822867519176 0.56465390755755 0.436491797894233 0.178129086565392 0.560729545604476 0.604723276894862 0.345439890034069 0.278441380091746 3.0 True False False False False False False 0 insufficient_or_context_specific +COL4A5 -0.357200038689318 0.162850080366806 0.56465390755755 -0.525115569375622 0.0366268565697088 0.377876708853838 1.61518948081162 0.0050813992631754 -0.837990600651271 0.0472051433427765 0.777198880160352 0.109569125016934 reversed False False False False False False False 0 insufficient_or_context_specific +KDM3B 0.235558056616623 0.163043415072685 0.564729799173832 0.0849096265226536 0.601652285041279 0.844264330869992 0.328024554554886 0.573138745250957 2.0 -0.419880254459078 0.100383894409887 -0.325925633758838 0.152762914008495 -0.745805888217916 0.0103761109185109 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAF2 -0.1839029920815 0.163054168795928 0.564729799173832 -0.217080607339626 0.0992933019160885 0.478125555523304 -0.290385832680308 0.280590486779761 0.180539228509631 0.436674079469168 -0.109846604170677 0.676180017484306 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTPA -0.665738708841743 0.163054912992992 0.564729799173832 -0.801811437774939 0.0909503536671641 0.472234212482528 -0.719400618748877 0.133579323162801 1.43448827333888 0.0063758975765378 0.715087654590006 0.107065915490912 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HYAL1 -0.502588924416107 0.163085921356414 0.564729799173832 -0.409471455167574 0.262982218160971 0.625916649987271 -0.991735812361416 0.0077315589540995 0.50498755686034 0.0912632109825349 -0.486748255501076 0.11309876698866 reversed False False False False False False False 0 insufficient_or_context_specific +MZF1 -0.31718289490909 0.163444326688005 0.565674480551987 -0.266759093344791 0.24541841964217 0.610826891697792 False False False False False False False 0 insufficient_or_context_specific +PI4KA -0.213669080056534 0.163465887494233 0.565674480551987 -0.240780935667194 0.114843366771769 0.492613299848511 0.417773756532915 0.267617210192384 2.0 -0.0865112920821779 0.795663869098636 -0.216790379467036 0.374682994036519 -0.303301671549214 0.240647604257735 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLDC -0.895494431669441 0.163539786262091 0.565744778294612 -0.967247782091378 0.13077765235224 0.516515197699258 -0.730123919505394 0.11347364555644 0.739435080840231 0.0760255557811435 0.0093111613348373 0.985741774065822 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBAP1L -0.25221609939955 0.1635989092711 0.565763931897893 -0.185427357610265 0.306400824675744 0.661696690217148 False False False False False False False 0 insufficient_or_context_specific +CAP2 -0.461279594228622 0.163745106489979 0.565900249915106 -0.209100955509708 0.528367321941751 0.805792602204392 0.775978466374006 1.0 False False False False False False False 0 insufficient_or_context_specific +POLR1B -0.440087478843806 0.163745525998357 0.565900249915106 -0.350087789728924 0.273487497287585 0.6371317291179 -0.238849963371769 0.552892169078678 -0.232119536158178 0.47181244859055 -0.470969499529947 0.179249752356567 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC47A1 -0.757435816139695 0.163874305422264 0.566074631457055 -0.929223677722589 0.0811013686038057 0.461068439742811 0.373027029607531 1.0 -0.673250221067848 0.118992787142097 1.11217552692038 0.0108412293210757 0.438925305852537 0.254362797065813 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDFY2 0.325693255286417 0.163945644310796 0.566074631457055 0.366450286716915 0.115863320901482 0.494328725999491 0.480387567049035 1.0 -0.321557235054079 0.196752049273969 -0.333860873337799 0.133202408819117 -0.655418108391878 0.0162522145230198 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ELOA -0.314714208192443 0.164041788707252 0.566074631457055 -0.390574581443418 0.0765211297515778 0.455668688469891 0.2850806409676631 1.0 -0.364945117286279 0.165204073345447 0.508297138092035 0.0387486096902615 0.143352020805757 0.566052857933979 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTSS1L -0.278300402897939 0.164105151096555 0.566074631457055 -0.380296754662438 0.060680724139867 0.429268745755419 False False False False False False False 0 insufficient_or_context_specific +MIR22HG -0.734640370607656 0.164117678243043 0.566074631457055 -0.95927269318327 0.0650750831426894 0.435400968200579 False False False False False False False 0 insufficient_or_context_specific +GUCY1A2 -0.584363017203824 0.164213188456567 0.566088626929788 0.443489502049713 0.264371324486385 0.627102323955796 0.332058462709136 0.2929636320021839 2.0 0.419965067911647 0.162764172242446 -0.24572339017379 0.3428830530156 0.174241677737857 0.547025172819312 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TSR1 -0.459000624662446 0.164266192343017 0.566088626929788 -0.411668240850325 0.215621374383372 0.587852789707652 0.301078526082719 0.316513871853418 -0.619716172050956 0.0279600477830352 -0.318637645968238 0.25119929228291 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF214 -0.207277220880926 0.164336203972324 0.566088626929788 -0.10678047382852 0.49385731622616 0.786363265568912 -0.0038861123159154 0.990317531063067 -0.254390279480669 0.214403582452915 -0.258276391796585 0.235288020367028 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRPF40A -0.177866229530588 0.164435951908241 0.566137811285775 -0.0488499645938598 0.703466181916773 0.891727211991511 -0.019162276199715 0.95762493377024 -0.0952261135489092 0.713102437415139 -0.114388389748624 0.684245175908717 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL5 0.337187628440557 0.164652206595301 0.566137811285775 0.496251836439586 0.0374493361233233 0.379484931484566 0.0498817191538282 1.0 True False False False False False False 0 insufficient_or_context_specific +MUTYH -0.372237294305351 0.164775004630745 0.566137811285775 -0.417623877646834 0.114163491459234 0.4924007041452 0.82648181197858 0.205545898991761 -0.759300652094303 0.133002350917479 0.0671811598842769 0.929848883257229 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLYBL -0.2800538822565 0.164902834592205 0.56637740000797 -0.322154342122175 0.105167896906701 0.482830329046451 -0.38295533029295 0.440337228511819 0.790058281022901 0.0547995028772914 0.407102950729951 0.3335913147832 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDK11A -0.466867248138972 0.165076897544876 0.566508265962038 -0.629803927904785 0.0543257908596072 0.419106270466538 0.853164277718182 1.0 False False False False False False False 0 insufficient_or_context_specific +SMC1A -0.29535705754555 0.165101907024549 0.566508265962038 -0.137693075072651 0.53391165392304 0.810501688298988 0.744808958298604 1.0 -0.0415361664532054 0.88617314023643 0.225074788426024 0.25728374882764 0.183538621972818 0.385655615665109 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XACT 0.974691094479121 0.165253513700166 0.566660148634735 1.20051521489869 0.0891042747662093 0.470236852611986 True False False False False False False 0 insufficient_or_context_specific +PPWD1 0.286876267059035 0.165465416064419 0.566972925771516 0.0430371914976976 0.828387314262444 0.942875513581596 -0.0398599401601776 0.940579315235297 -0.702352981360079 0.0625678580436086 -0.742212921520257 0.0719165601208997 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC027031.2 -0.647365820051149 0.165505830387177 0.566972925771516 -0.14524791911571 0.763151666741481 0.916866798061945 False False False False False False False 0 insufficient_or_context_specific +IPO9-AS1 0.503957375563887 0.165593550238909 0.567066880422954 0.757859403556261 0.0429675669639925 0.391483132487066 0.0393198223653488 1.0 True False False False False False False 0 insufficient_or_context_specific +Z94721.1 -0.508269587607453 0.165650493210967 0.567066880422954 -0.369212000551913 0.313552714546558 0.666228528915789 False False False False False False False 0 insufficient_or_context_specific +PDCD1LG2 0.649222782979593 0.165947621836306 0.567699503511581 -0.12077559649999 0.78647557030342 0.926121604088118 False False False False False False False 0 insufficient_or_context_specific +TMCO6 -0.65318408006477 0.166009396567734 0.567699503511581 -0.616746849608869 0.194975514328075 0.571343735852293 -0.320848160733401 0.416984035146931 -0.497683317157382 0.14353383948489 -0.818531477890783 0.0355264612821072 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DLST 0.303299428831162 0.166040544311779 0.567699503511581 0.275660958618557 0.211428470950935 0.583597855241824 -0.0181093927474569 0.956587192113681 0.231285798742146 0.305214491645199 0.213176405994689 0.37135754729829 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TERF2IP 0.305086455504917 0.166195051103689 0.567829655720814 0.230289029730571 0.292186497911173 0.651509781962399 0.0835595712160257 1.0 -0.0016148355236368 0.99699280592687 0.407928502263081 0.167843192587712 0.406313666739445 0.210829160135737 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AKR1C4 -0.795760695619942 0.16624538757719 0.567829655720814 -0.942190110257339 0.0970847686137883 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +TBC1D10A -0.423681514533986 0.166258654109934 0.567829655720814 -0.554076045758968 0.0630769336768746 0.432999502601999 -0.277197768065315 0.34025543941772 -0.262648002188941 0.294123166979309 -0.539845770254256 0.0538286229571822 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NCLN -0.463442991541189 0.166293738917291 0.567829655720814 -0.10827200406786 0.752094283691097 0.912923826995931 0.935722334562648 1.0 0.0933525855397517 0.748673067824995 -0.0552669469551161 0.815994697785536 0.0380856385846356 0.887898006656482 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DMGDH -0.791346940196836 0.166495146878264 0.567989912537313 -0.853960609006866 0.134198347062738 0.520900171021663 -1.16831901008915 0.0147719330496397 1.74003396281116 0.0019872992848927 0.571714952722013 0.155051376325398 reversed False False False False False False False 0 insufficient_or_context_specific +TRAF2 -0.414309466355126 0.166502062824681 0.567989912537313 -0.383299245278104 0.203839167880506 0.577025563405608 0.43482699696769 1.0 -0.239814078776954 0.448586650946601 -0.415924040385904 0.123980604873741 -0.655738119162858 0.032998538588555 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPR137B 0.484781545551001 0.167244995279604 0.568715760001446 0.675565655405589 0.0517861191992075 0.411906134371584 0.4135043739866521 0.0477924148191561 2.0 True False False False False False False 0 insufficient_or_context_specific +ZDHHC11 -0.422006858806428 0.167374639760149 0.56876132815824 -0.17134381370201 0.577810672299652 0.83075298180061 False False False False False False False 0 insufficient_or_context_specific +NUP210 -0.835378963816448 0.167651798036696 0.569216736360976 -0.764715539803011 0.209382683308508 0.581735440450297 -0.507768904868592 0.291669127754658 0.118000162364805 0.786241638006412 -0.389768742503787 0.371897608816055 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C2ORF68 -0.353734953481799 0.167681522048824 0.569216736360976 -0.201916597478958 0.440055468005002 0.756769095948255 0.564694980742975 1.0 False False False False False False False 0 insufficient_or_context_specific +STMP1 0.312996932836753 0.167692010497447 0.569216736360976 0.10214445330084 0.653928749515376 0.870640572179488 0.136918138014688 0.379330777005906 2.0 True False False False False False False 0 insufficient_or_context_specific +SOX6 0.358530867273587 0.16772431017418 0.569216736360976 0.352491961971004 0.174859556357104 0.556905394035785 0.289345601889214 1.0 -0.72720592797369 0.0683562842543733 0.381766937216284 0.264950314766711 -0.345438990757407 0.336907170095018 reversed True False False False False False False 0 cross_species_direction_conflict +LINC01081 -0.880764992683301 0.167872463447399 0.569536461785874 -0.827704876658428 0.196748545889679 0.571879675616801 False False False False False False False 0 insufficient_or_context_specific +DHX37 -0.451940235123336 0.168192425069931 0.570157213663304 -0.517677528183832 0.107029185824204 0.483261130274234 0.469158506798626 0.152082980876091 -0.513277807378772 0.0729066936551299 -0.044119300580146 0.903396239782495 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF235 0.267192101958812 0.168217438962037 0.570157213663304 0.0081805018194385 0.966925982346523 0.990805143378026 True False False False False False False 0 insufficient_or_context_specific +SPAG7 -0.393636823715085 0.168360808751237 0.570163793948294 -0.507665720327374 0.0685717323599166 0.438244764077482 0.341390752314691 0.350220498427523 2.0 -0.162806044520187 0.569746048556432 0.271203799510962 0.230002774478682 0.108397754990774 0.676207841115277 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPATCH1 -0.346124460612973 0.16838138942326 0.570163793948294 -0.176374113276814 0.489940028132791 0.784627322682213 0.38573018745663 1.0 0.510664408076228 0.293180885970971 -0.515861259665715 0.182337786833112 -0.005196851589487 0.99326446525708 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NVL -0.195418686526476 0.168531820001705 0.570490206982367 -0.0563919038149363 0.705948493967876 0.892947759038953 0.318187922821502 0.17083230919365 -0.288727766299742 0.154024132512887 0.0294601565217601 0.907868584890725 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAHD2A -0.362016860389967 0.168604415672096 0.570553019444227 -0.275135142524267 0.302831699323697 0.660051093047527 0.261619303817445 0.469419505022995 0.150654713816604 0.597953872318223 0.412274017634048 0.190986137495533 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANGEL1 -0.375164616533443 0.168733925168742 0.570679773317849 -0.420140837650624 0.121669020050188 0.503485437181972 0.316072754675121 1.0 0.0442424968037498 0.949213952797514 0.0022220107668575 0.996645110988921 0.0464645075706074 0.935957264826206 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EEF1D -0.372255427714966 0.168824580693009 0.570749254869288 -0.32630092641881 0.233024235783056 0.602604162857471 -0.379937152331481 0.203216330643772 0.0209891258389478 0.94472613140216 -0.358948026492533 0.193432137570132 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIGZ 0.477343358422003 0.169079107953714 0.570832862139676 0.573191570407792 0.100496381506506 0.478125555523304 0.563515365342134 0.0293361501424223 2.0 True False False False False False False 0 insufficient_or_context_specific +SNTB1 -0.582374476769657 0.169119643187432 0.570832862139676 -0.333222114636081 0.432391152977299 0.75112354555773 0.254570752556242 0.9773897606426459 2.0 -0.190333288015866 0.522829510969909 -0.502272896710241 0.0537761425872147 -0.692606184726107 0.0205210781351541 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COG1 -0.328557616349232 0.169422926699184 0.571337398444576 -0.264800205278695 0.27322014946948 0.637071187742661 0.5365793623780329 1.0 -0.0388895345374266 0.930311903253838 0.0533491035308919 0.870990262223296 0.0144595689934653 0.969585471564195 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TUBGCP6 -0.418721449996137 0.169467128691236 0.571337398444576 -0.645908902212432 0.0296554956942331 0.371414855918995 0.455087920637799 0.11053449046293 -0.575893445644443 0.0297827090668634 -0.120805525006644 0.675147961711509 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BORCS8-MEF2B -0.422875173516415 0.169541865279247 0.571344721869866 -0.408500190571305 0.186614140469227 0.568949493235375 False False False False False False False 0 insufficient_or_context_specific +PPARG 0.64576202336391 0.170052857981402 0.571856753217971 0.518243363039298 0.269273373543203 0.633720010321031 True False False False False False False 0 insufficient_or_context_specific +ARHGAP39 -0.555392485722017 0.170141033019988 0.571856753217971 -0.581184776622721 0.151732417117591 0.534368029741253 0.6693842631518921 0.260240368152701 2.0 -0.357840584992083 0.230383719721235 -0.333981899089757 0.201768385424984 -0.69182248408184 0.0265665665001751 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FPGS -0.443912773418379 0.170348006304466 0.571856753217971 -0.486304917382155 0.129077896532514 0.513297337698789 0.3686473584484261 0.250510429990611 0.0395009586784388 3.0 -0.517757344150493 0.149029449922273 0.0612724168587868 0.863845838853225 -0.456484927291706 0.168879378608484 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF846 0.305231605836563 0.170446545152788 0.571856753217971 0.128890179839226 0.567051929905894 0.824646594482979 True False False False False False False 0 insufficient_or_context_specific +GPSM1 -0.380633920936933 0.170467166597648 0.571856753217971 -0.361363129239229 0.195380741221988 0.571500015361699 0.47375050694619 1.0 0.279886057024468 0.519022082221429 -0.287072019616536 0.419728544197953 -0.0071859625920683 0.987382235828688 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DTX4 -0.585313446273892 0.170475532044355 0.571856753217971 -0.716950336963251 0.0912797009577494 0.472234212482528 0.5449545197017 1.0 0.0633609902742694 0.869015643979454 -0.27115603782345 0.308624631277282 -0.207795047549181 0.472621933640747 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF13 0.336952252961651 0.170514853617943 0.571856753217971 0.448972157994087 0.0669501073209785 0.436862290339161 0.0529388115112964 1.0 -0.253463779387306 0.380024802584681 0.596436421922641 0.0257020539378619 0.342972642535334 0.181535181368616 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZKSCAN5 -0.299620824432888 0.170518586533301 0.571856753217971 -0.373980242945908 0.0810363240287216 0.461068439742811 0.473218760532915 1.0 -0.486175869327437 0.33070857151639 -0.0008407718956778 0.998693746778008 -0.487016641223114 0.283776487103477 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MMAB -0.423376713749269 0.170599429698488 0.571856753217971 -0.723496761236764 0.0185518414045422 0.327267058068343 0.359575799859814 0.390322177355621 -0.273204422407474 0.420122371101311 0.0863713774523396 0.841757393942021 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AKT1 -0.357736237793124 0.17066913398823 0.571856753217971 -0.193226700476936 0.452634668054072 0.76491545430188 0.490434002026515 1.0 -0.0486202300218082 0.882039119544774 -0.107967963823303 0.648990842611329 -0.156588193845111 0.524136664461994 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WIZ -0.413684390803158 0.171019707335845 0.571856753217971 -0.234274782530822 0.449114046883197 0.76344326308047 1.04356102702043 0.796755803337568 2.0 0.237374324478437 0.382191033435019 -0.360416453544226 0.117032950560062 -0.123042129065788 0.637302107524846 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAPZA1 0.23024550910492 0.171105142256366 0.571856753217971 0.0313854820239366 0.852542434075776 0.954623291862556 -0.023951094246303 0.968116425705772 0.532865616300193 0.156446660890052 0.50891452205389 0.223318957203438 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BAZ2A -0.260127094755451 0.171116783005436 0.571856753217971 -0.344920134647569 0.0588530489658402 0.427941109491281 0.334125039859721 0.8087630274107329 2.0 -0.0607646025980204 0.843696053451533 -0.466689292965106 0.0451338338564942 -0.527453895563126 0.035042795965661 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KHNYN 0.370728140099171 0.171200899963582 0.571856753217971 0.450150155215321 0.0953247530283531 0.475183542244264 -0.212641903932454 0.488335954733525 -0.374103773894645 0.146641609710347 -0.586745677827099 0.0423588637368009 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PTGFR -0.889830087806709 0.171214828829913 0.571856753217971 -0.71407908536756 0.28159534744678 0.64315368591277 False False False False False False False 0 insufficient_or_context_specific +NSMF -0.538388685988394 0.171240238666037 0.571856753217971 -0.382558836485833 0.352027064793757 0.696141927344537 0.467572099962433 0.5508853952855849 2.0 -0.291245857610203 0.306557077244755 -0.356024088998768 0.155189893128554 -0.647269946608971 0.0264031224071693 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XBP1 -0.312822836616474 0.17132263311674 0.571856753217971 -0.265469873445903 0.245215120302171 0.610669341516615 0.365645112914997 0.6340289100613671 2.0 -0.530733972981429 0.0771318970122348 0.581411492948322 0.0407620513677333 0.0506775199668927 0.87407083210624 reversed False False False False False False False 0 insufficient_or_context_specific +PARP3 -0.811292179281408 0.17134262876332 0.571856753217971 -0.845122210802536 0.153594149223244 0.536502535641712 0.510083692309204 0.235582460237373 -1.23134152285522 0.0080807149151296 -0.721257830546016 0.0833189204387499 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB22A 0.28271026973946 0.171347537067463 0.571856753217971 0.377756302241004 0.0630172623503068 0.432999502601999 -0.14953237480834 0.596454233907932 -0.115626617668317 0.620971800241811 -0.265158992476657 0.266746233628446 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PATZ1 -0.410663394590575 0.171351291800856 0.571856753217971 -0.234496671867374 0.442045020919674 0.758062305003835 -0.110539119938645 0.740261315262556 -0.222171137719577 0.381989561295581 -0.332710257658222 0.213675291583889 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SSR3 0.448182517887889 0.171372870541927 0.571856753217971 0.453141382468907 0.167330159512417 0.547623080618609 0.915019898569934 0.0162145266341364 2.0 -0.0109431854952085 0.976990261293941 -0.029879903752841 0.921116025236588 -0.0408230892480495 0.897315960328096 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARRDC2 0.405176488818483 0.171508919755659 0.572046717378676 0.273584523684124 0.345519432794364 0.691144142244059 0.79014936339706 0.3908425720171571 2.0 -0.371645824936824 0.3168657007566 -0.305341813987839 0.336744700260272 -0.676987638924663 0.0609682035927442 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SUPT6H -0.313099914720446 0.171573621304824 0.572046717378676 -0.299934048799926 0.191085508858685 0.570393215303929 False False False False False False False 0 insufficient_or_context_specific +FRA10AC1 0.237485411513295 0.171763428820561 0.572046717378676 0.349717545412579 0.0345293015478226 0.37720666979567 -0.240255230989006 0.403880964912857 -0.0973259525256476 0.701697581591658 -0.337581183514653 0.191732222501831 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BCORL1 -0.373518786023728 0.171810776261627 0.572046717378676 -0.05161396313694 0.864084281748701 0.958391272020028 -0.103203983241273 0.763984226718305 -0.518411046237365 0.0556066277348169 -0.621615029478637 0.037480318894471 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FLG-AS1 0.473026397203409 0.171934502029982 0.572046717378676 0.231823685878197 0.51195220425872 0.797108298564159 0.0531301807879357 1.0 True False False False False False False 0 insufficient_or_context_specific +MYRIP -0.57099705202931 0.171940740522783 0.572046717378676 -0.666037617445412 0.111162665675365 0.488819418659101 1.39457596719414 1.0 False False False False False False False 0 insufficient_or_context_specific +HTR7 0.628527871672365 0.172082837682063 0.572046717378676 0.376661123698375 0.408667273243888 0.734801770489731 True False False False False False False 0 insufficient_or_context_specific +SF3A1 0.345431828564656 0.172097452222206 0.572046717378676 0.207767726560864 0.407285254947292 0.734118519162987 -0.102942807777883 0.752930021032206 -0.188220032212706 0.43900489388738 -0.291162839990588 0.26282628734446 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C5 -0.528933667020653 0.172115493075763 0.572046717378676 -0.58682734827724 0.127997746544183 0.511104106212365 1.30472618080363 1.0 False False False False False False False 0 insufficient_or_context_specific +WDR45 -0.432097666260531 0.172154758837515 0.572046717378676 -0.582775477397152 0.0563731192725933 0.423637335496119 -0.361165066293921 0.291407874813288 0.699988881679284 0.0275718322755925 0.338823815385363 0.267377095325108 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC123912.1 0.597196853799295 0.172204201671525 0.572046717378676 0.225883190884588 0.599332108694191 0.843166766555993 True False False False False False False 0 insufficient_or_context_specific +MNT -0.415198675349494 0.172242518900058 0.572046717378676 -0.54428965335243 0.0584209384492634 0.42715254026823 0.529210051334208 0.254398203430612 2.0 -0.136565206685318 0.74046846137411 -0.0190449167468769 0.956413063763894 -0.155610123432195 0.658934955745295 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HECA 0.44065461781172 0.1726304344505 0.572794508776989 -0.0823205805860474 0.79874620010083 0.92925379048471 0.321569711996896 1.0 -0.474317456838086 0.0787175219941588 0.0467389851329872 0.86158041866508 -0.427578471705099 0.092552405275499 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF658 0.441573704878607 0.172795684786463 0.573051190684154 -0.210748460871241 0.509534992034573 0.796280409399204 False False False False False False False 0 insufficient_or_context_specific +ZSCAN21 -0.453543898848112 0.173055752066125 0.573051190684154 -0.35901755834496 0.284582332642247 0.645322222516505 0.434952030605258 1.0 -0.376339252714953 0.280514283897767 0.0487506190051974 0.887337524258271 -0.327588633709756 0.302923419581259 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PGR 0.467267212810608 0.173074812612928 0.573051190684154 0.418315650552484 0.220448525208492 0.592539594997775 True False False False False False False 0 insufficient_or_context_specific +CLIP1 -0.203800119444864 0.173086300507707 0.573051190684154 -0.215571336449297 0.147306081163272 0.532796338690088 -0.189770260397975 0.477097489833652 0.0656531043198032 0.783828530214153 -0.124117156078172 0.612155075027987 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBX3 -0.273204711427102 0.173087729408199 0.573051190684154 -0.332974725867566 0.0918767155224852 0.472460751419842 0.20266730973261 2.15360932633452 2.0 -0.165204039856376 0.809003268319995 0.0025574902050982 0.996560338234433 -0.162646549651277 0.777674424581301 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIAH1 0.344582003543766 0.173275370566217 0.573492590105994 0.521895154485213 0.0400154285694597 0.38268378155467 0.0750363306762418 1.0 True False False False False False False 0 insufficient_or_context_specific +C10ORF88 -0.334951050389526 0.173335131252601 0.573494904367005 -0.0827841588216766 0.748171451663727 0.910255149419869 0.456991607333703 1.0 False False False False False False False 0 insufficient_or_context_specific +SERPINB1 0.463908783257269 0.173384706832684 0.573494904367005 0.21261816720802 0.540264974718394 0.812783927483158 0.4423296595703211 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF704 0.459366165362771 0.173657753896025 0.573676192501689 0.655039186674296 0.048386858122181 0.403191887129892 0.348299751447064 0.248018449984326 0.141192257896916 3.0 True False False False False False False 0 insufficient_or_context_specific +TMEM94 -0.490960276882829 0.17365988950491 0.573676192501689 -0.374194463220977 0.301119634966186 0.658632920234719 -0.146066377200256 0.616569134632343 -0.571771022132301 0.0270728474915667 -0.717837399332557 0.0150451173382639 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNTNAP3B 0.748919977155435 0.173737817163575 0.573676192501689 0.132766537742562 0.807325395721278 0.932788199072101 True False False False False False False 0 insufficient_or_context_specific +CYB5D2 -0.376255204502592 0.173982163983942 0.573676192501689 -0.640418640184314 0.0106206750412834 0.302245517751671 0.7343386587819709 0.4133149571748549 2.0 -0.052131892839377 0.916672060413173 0.35439542839987 0.26191310689374 0.302263535560493 0.384163052306163 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XPO6 -0.234353629759351 0.17409752156324 0.573676192501689 0.0129852985319232 0.937733295622147 0.982883762054862 -0.22085286268383 0.386966283877942 0.115539345403825 0.601502083685288 -0.105313517280005 0.66613947490803 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LPCAT4 -0.577287486807419 0.174111599323147 0.573676192501689 -0.443664130597404 0.302507986328224 0.659910120213739 -0.202695003754155 0.786774563585364 -0.664268852557359 0.231450018239794 -0.866963856311514 0.162654511815043 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PEX5 -0.315171704432022 0.174212382535849 0.573676192501689 -0.205211480942197 0.375504450288422 0.713241132346407 -0.417440656006351 0.218973840370977 0.238083296660983 0.427004566291826 -0.179357359345368 0.581479711140338 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPCS3 0.441471415359001 0.174263688966822 0.573676192501689 0.371523809759385 0.252773068446448 0.618991529980024 -0.245816356295253 0.520316567244718 0.159426190478862 0.620971800241811 -0.086390165816391 0.81546701095821 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CWC25 -0.304319525715441 0.174279362660715 0.573676192501689 -0.49162735368858 0.022152816504246 0.346028040476539 0.332425627050691 1.0 -0.12735246548011 0.751798143959638 -0.5109640549449 0.0977440852124554 -0.63831652042501 0.061019286714691 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASIC2 -0.847140874803052 0.174284420544098 0.573676192501689 -0.785807840996233 0.209841704862211 0.581956585220706 False False False False False False False 0 insufficient_or_context_specific +C11ORF80 0.572318810738626 0.1743100874859 0.573676192501689 0.763763769448622 0.0692350062073149 0.440882506355145 True False False False False False False 0 insufficient_or_context_specific +PCSK7 -0.224146114844948 0.174363222365781 0.573676192501689 -0.321570862187294 0.0499396014322691 0.40534943521819 0.66338288650333 1.0 -0.192581804262677 0.497432374295653 -0.432679508420608 0.0749789924556704 -0.625261312683286 0.0261123460869507 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GAREM1 -0.287943107361007 0.174594491706387 0.573943487468955 -0.308535212392385 0.145792193275564 0.532658823056677 0.6416678823917921 1.0 -0.813321068227896 0.019325187030511 0.57391286159015 0.0548465744701385 -0.239408206637746 0.420542301163057 reversed False False False False False False False 0 insufficient_or_context_specific +AC116366.3 0.307213723950715 0.174700024501901 0.573984996462129 0.298982892379536 0.186732542368396 0.569146126537392 True False False False False False False 0 insufficient_or_context_specific +BCL7B -0.501014471745467 0.174728904965835 0.573984996462129 -0.55815290398629 0.126831318026185 0.508384607335028 0.0004740421213274 0.99931014544354 0.40006981680138 0.288010436579182 0.400543858922707 0.342466797299711 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARMH4 0.25012581145251 0.174961834170507 0.574571398187312 0.0594862826340771 0.756608212169025 0.914454644719928 0.7373555379173741 1.0 True False False False False False False 0 insufficient_or_context_specific +MVK -0.586782734805748 0.175179848552594 0.574626867390613 -0.857950708822119 0.0364850406307845 0.377876708853838 0.163125369333521 0.731142055774875 -0.548643819570964 0.130966283670881 -0.385518450237443 0.320654852970786 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPL32 0.412423576359376 0.175191521355131 0.574626867390613 0.105928771885985 0.724626032253156 0.902725858233488 0.149602703645189 0.0216496600357377 2.0 True False False False False False False 0 insufficient_or_context_specific +AC006030.1 0.368445844258045 0.175196427934304 0.574626867390613 0.299744294413791 0.270555594432563 0.634531964851516 True False False False False False False 0 insufficient_or_context_specific +IREB2 0.244692646180749 0.175307964778688 0.574720378200521 0.271272269502958 0.132344976839498 0.518682589655195 0.2905458862600711 0.7455880998179192 2.0 -0.130793446688196 0.650505809379667 0.0271541110164814 0.918390281539341 -0.103639335671715 0.687650726231379 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CCDC138 -0.267966720193479 0.175333807367293 0.574720378200521 -0.25252324008528 0.202705096589083 0.57668584531318 0.109865995445206 0.914827918728458 -0.200385944674502 0.761283047528618 -0.0905199492292969 0.917649081729215 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BOD1 0.501569165967534 0.175388278670105 0.574720498509922 0.786422724468054 0.0297524090616324 0.371448754340933 0.0250278345812606 1.0 -0.26584127548432 0.573573228483649 0.485648010151038 0.174591095652299 0.219806734666718 0.589535480158036 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DAB1 0.413831572908402 0.175704365868947 0.575222513041252 0.440500432892525 0.149619042540742 0.533583468169136 0.321449452989246 0.404354823084341 0.149524852358385 3.0 True False False False False False False 0 insufficient_or_context_specific +FHL3 -0.476271871273265 0.175758407143681 0.575222513041252 -0.508104202561558 0.148632303216989 0.533583468169136 0.969821941866066 0.0575428442719298 -1.54249457179779 0.0051727148090469 -0.572672629931727 0.251615726365561 reversed False False False False False False False 0 insufficient_or_context_specific +TAF1C -0.39401225994588 0.175873309123326 0.575345185276449 -0.226493816427083 0.44191107948522 0.758062305003835 0.720966282811058 1.0 0.136104264921448 0.856860196217495 -1.04278215698702 0.0598570493122512 -0.906677892065568 0.140498848768317 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FLVCR2 -0.498754965340341 0.175905877824624 0.575345185276449 -0.562047123184969 0.122265262901662 0.5038394341269 False False False False False False False 0 insufficient_or_context_specific +KHK -0.629092391972032 0.176165155252676 0.576014775211444 -0.739543331699299 0.108510962285821 0.485105595812652 0.471851325717026 1.0 -0.683498780717515 0.115465426482919 0.764132486230055 0.0583257243490327 0.0806337055125398 0.859101658571639 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPHA1-AS1 0.772004269413782 0.176273691196104 0.576191217228628 0.647071506956964 0.253586422659204 0.618991529980024 True False False False False False False 0 insufficient_or_context_specific +CES3 -0.998874397564113 0.176410236686038 0.576459077354129 -1.18002266231426 0.0991038201746347 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +ABCB8 -0.433200856795959 0.17652124883081 0.576643361743716 -0.40538095847813 0.208271208596632 0.58080491821533 0.164995114178792 1.0 -0.200044683177558 0.784039873542692 0.30235558764059 0.551273165825599 0.102310904463032 0.874955363271544 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TPD52 -0.416028313727096 0.176823302623491 0.577451416362146 -0.0198987155740096 0.951917845004134 0.986917609553614 0.601938227218806 0.320349903765884 -0.864987739921945 0.0814634999037449 -0.263049512703139 0.682847153251179 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UPF2 -0.162837493769962 0.177078455108922 0.578105853135437 -0.156711863216024 0.192964106229052 0.570885363891703 0.0872389404264011 0.80413025909134 -0.438804711149236 0.0883164561458251 -0.351565770722835 0.198633796590307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIN 0.244476171620242 0.177171653059618 0.578231317775409 0.156936518902501 0.383263077823913 0.718967005626005 -0.288562666174539 0.457696546809139 -0.411473836590683 0.205240723211765 -0.700036502765223 0.0570413970686853 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF615 0.445077488894998 0.17737126943818 0.57870391308044 0.515959302360538 0.120139353148864 0.500999836515407 True False False False False False False 0 insufficient_or_context_specific +HOXA-AS2 -0.491523657112739 0.177474280092054 0.578861121165249 -0.0183918846997206 0.960458338264062 0.988836580730567 False False False False False False False 0 insufficient_or_context_specific +IWS1 -0.205416117567949 0.177753231964412 0.579391668975509 -0.0465015474653574 0.768565728780245 0.919804688785064 -0.129387234852138 0.776948216936043 -0.238913457121527 0.482152807138785 -0.368300691973665 0.307330341007821 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APOLD1 0.756879405902786 0.177826287952947 0.579391668975509 0.8694065772066 0.127368571768152 0.509570814978457 0.271026894153442 0.0331898734357704 2.0 -0.50030813768094 0.317115335171493 -0.329600018674323 0.450238927452536 -0.829908156355262 0.0824593825610639 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MARCO -1.19253101658925 0.177863339397277 0.579391668975509 -1.16102545074385 0.191571521226364 0.570552915001293 1.09216735689993 0.361818518891311 -1.12615919798815 0.252135761041561 -0.0339918410882152 0.980873751510795 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FERMT3 -0.362722912644889 0.177906023185767 0.579391668975509 -0.0848416627653079 0.763900345748604 0.917095887442426 0.758097183367242 0.182734046061379 -0.647139027499815 0.147955924599069 0.110958155867428 0.862466936802174 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LZTS1 -0.545843065170967 0.17806827114211 0.579723961368607 -0.26368431293786 0.528355424459092 0.805792602204392 0.562443651783673 1.0 False False False False False False False 0 insufficient_or_context_specific +NELFA 0.267416555584782 0.178176852791499 0.579898647278866 0.0076474463041763 0.966928722341264 0.990805143378026 0.25482389312774 1.0 -0.35852875177488 0.175144956637759 -0.211506570586446 0.362568393658862 -0.570035322361326 0.0335609359811547 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NINJ2 -0.430986127544054 0.178292460956108 0.580009366843818 -0.502473958312678 0.109937460467348 0.486470958765405 0.484700558340755 1.0 False False False False False False False 0 insufficient_or_context_specific +TTLL3 -0.374919542108308 0.178329244820328 0.580009366843818 -0.219295457504441 0.438856599243622 0.755987595825446 0.25344797708011 0.759052885175739 -1.9743604970351 0.0128507403413919 -1.72091251995499 0.0400305619911369 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM184A -0.564677082923394 0.178385903128143 0.580009366843818 -0.402006690349911 0.342694163844536 0.689436924899125 -1.24745747094276 0.108491850178158 -1.05182523563057 0.19342562364249 -2.29928270657334 0.01519228421204 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXL20 0.278338385227386 0.178430614084933 0.580009366843818 -0.0049578770863721 0.981739137084103 0.99451887511202 0.7483817396943679 1.0 -0.0707143690025226 0.885130826731918 0.160735574656983 0.637595074213904 0.0900212056544605 0.820809532234531 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FOXF1 -0.410409543512811 0.178535305448379 0.580034678264022 -0.248798879515241 0.421140602669392 0.742924391475929 -0.724834591312495 0.0254489527712211 0.921829150970449 0.0063649404045111 0.196994559657954 0.493276501795087 reversed False False False False False False False 0 insufficient_or_context_specific +C19ORF12 -0.291388289528836 0.178548276601446 0.580034678264022 -0.348991469692425 0.103920464931007 0.480082620019266 False False False False False False False 0 insufficient_or_context_specific +PIAS1 0.237469491003408 0.178921262849623 0.580473135729219 0.155434877719766 0.38040587597197 0.716671165026344 -0.246585167540328 0.376978380519378 0.140382233561166 0.558227669983935 -0.106202933979162 0.693655116531792 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HABP2 -0.596135305065627 0.178943062145899 0.580473135729219 -0.70733860335746 0.109183403068209 0.485176912870447 -0.887274306409073 0.0478201511228984 0.874798262140148 0.0353819366874266 -0.012476044268925 0.980088887108866 reversed False False False False False False False 0 insufficient_or_context_specific +AGXT2 -0.85659397199927 0.178974681377604 0.580473135729219 -0.638276868948774 0.322956783431595 0.673203893281496 -1.24554976131825 0.0042629406700174 1.54679113324721 0.0014901079403511 0.301241371928962 0.363758498193259 reversed False False False False False False False 0 insufficient_or_context_specific +ZFYVE19 -0.48503817975665 0.178975764532082 0.580473135729219 -0.518300024567007 0.149772143012792 0.533583468169136 0.0979357355960825 0.797189358910681 -0.368651614052261 0.176249037617341 -0.270715878456179 0.366290580919471 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAD54L2 -0.218520818564111 0.179106849520833 0.580473135729219 -0.27886239945992 0.0835912132141262 0.464779732481256 0.971391689656701 1.0 -0.411237510812152 0.205545898991761 0.0231070304778949 0.943918697461471 -0.388130480334258 0.195619592462982 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLMN -0.717461653458044 0.179153488781345 0.580473135729219 -0.835941109347758 0.115095987159789 0.492975023299411 -0.953709684119573 0.0121320074228118 0.919683305904313 0.0108012686273956 -0.0340263782152599 0.927177905708643 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF823 -0.324435393245124 0.179194759450873 0.580473135729219 -0.264409924368539 0.280226531633956 0.642477283866194 False False False False False False False 0 insufficient_or_context_specific +TBX2 -0.41535974195887 0.179228529483107 0.580473135729219 -0.33505045818053 0.286736634552635 0.647011196325437 0.474621732522702 0.359271381218174 -0.230479033825908 0.613627447867422 0.244142698696794 0.619316724447865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RASA1 0.313331434158202 0.179385806845539 0.580473135729219 0.336878369037651 0.147721237354277 0.532846198833773 -0.424177879550884 0.240707069478445 -0.368627081391085 0.245315963897729 -0.79280496094197 0.0318010841651968 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NARFL -0.466168520589036 0.179536305600337 0.580473135729219 -0.453116212096691 0.193288905121596 0.570885363891703 False False False False False False False 0 insufficient_or_context_specific +CAB39L 0.447795144812433 0.179598471475321 0.580473135729219 -0.116605809183477 0.73679600978033 0.906049555039219 0.943729663302329 1.0 -0.0637414350794731 0.929867855578651 0.289663180311138 0.527726797503334 0.225921745231665 0.672128313056294 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDX18 0.315383198422028 0.179608970563005 0.580473135729219 0.274332225805915 0.247172760910939 0.612557966068705 0.0521027162694127 1.0 -0.28756814874807 0.326855370011508 0.0203166161585247 0.94375778815752 -0.267251532589546 0.315446148899377 partial_or_other True False False False False False False 0 cross_species_direction_conflict +METTL8 0.299744354966199 0.179611865785412 0.580473135729219 0.452301646559792 0.0377816399861731 0.379484931484566 0.0501321144144547 1.0 -0.219165640359407 0.5491287074965 -0.051742533012455 0.874620752748553 -0.270908173371862 0.391579376108947 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC01572 0.512246111113324 0.179659351536405 0.580473135729219 0.801020691274167 0.0352681500386535 0.37720666979567 0.0300643581613368 1.0 True False False False False False False 0 insufficient_or_context_specific +ECHDC3 0.482523468848947 0.1798254125716 0.580473135729219 -0.159535244158816 0.618188689556891 0.853292742102452 0.706180173700397 0.42271825813707 2.0 -0.535736353100245 0.168011290456542 0.776215468232038 0.0280946579686775 0.240479115131794 0.492784987550178 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAD23A -0.314217176358346 0.179828954960004 0.580473135729219 -0.373870617284857 0.105905288669198 0.483261130274234 0.74653739618831 1.0 -0.345449351339461 0.353814130855971 0.689711136668328 0.0398515253130048 0.344261785328867 0.296547419537758 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LOXL4 -0.590704485319064 0.179870053942575 0.580473135729219 -0.373925520165585 0.418851357052997 0.740618427024877 0.67347680103935 1.0 -0.377869339502605 0.369649684210199 -0.364745459316937 0.311917074620382 -0.742614798819542 0.0655998642507666 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITFG2 -0.272917973639745 0.180053538505338 0.580473135729219 -0.311161134334312 0.123086379036278 0.504414033284339 0.948489507572307 1.0 -0.381111081814929 0.228611703084623 -0.164255410575398 0.558036321027118 -0.545366492390327 0.0744816850310167 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TPRA1 -0.359080107697172 0.180057730584693 0.580473135729219 -0.430414609362434 0.10054120041234 0.478125555523304 0.7251843367340981 1.0 0.151120979277255 0.571444856082538 -0.237955210548043 0.258578864972825 -0.0868342312707885 0.727308351985174 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C9ORF72 0.351893715472274 0.180174124794699 0.580671065196103 0.375644171913628 0.15350816516036 0.536502535641712 -0.263062422331455 0.664755840571748 0.0704086789672734 0.893028423203212 -0.192653743364182 0.721586721852524 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CYP4A11 -0.723628717916742 0.180434535689995 0.580747619213834 -0.628194762511346 0.249254128717105 0.615185358140767 False False False False False False False 0 insufficient_or_context_specific +STARD4-AS1 -0.610101718839109 0.180450586022929 0.580747619213834 -0.306444839373591 0.501097026929375 0.790819493321426 False False False False False False False 0 insufficient_or_context_specific +NUCB1 -0.27102620793688 0.180533957510425 0.580747619213834 -0.261966252988221 0.195905805529608 0.571700325195908 -0.413203755452543 0.151699190005505 0.439610367662796 0.092187406925971 0.026406612210253 0.931985800935355 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRSF6 -0.296362925450894 0.180608377324407 0.580747619213834 -0.297878643632782 0.178013844252748 0.560533900274534 0.188230141185413 0.6064411405849399 2.0 -0.151612165133419 0.688522162517445 -0.649475969279899 0.042362259966393 -0.801088134413318 0.023257696200555 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC001226.2 0.506200888739304 0.180753989612089 0.580747619213834 0.337759696891805 0.366218358740909 0.707887999926555 True False False False False False False 0 insufficient_or_context_specific +PARP12 -0.346184960016904 0.180874150019012 0.580747619213834 -0.156364009921166 0.550838331681793 0.81739298747665 -0.0029918428896694 0.993658320585987 -0.425774043133548 0.0820142590455269 -0.428765886023217 0.0963311720207508 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC22A10 -0.837499286771134 0.180942637145487 0.580747619213834 -0.557969410542429 0.379910078296948 0.716424065042321 False False False False False False False 0 insufficient_or_context_specific +INO80D -0.177404606456595 0.181353244024531 0.581028262182095 -0.14893798649279 0.267836783763823 0.631491907766513 1.11886071492187 0.6545700361979471 2.0 0.113480820219989 0.683628821522331 -0.0623482252875926 0.786576728329241 0.0511325949323965 0.843400219548336 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANO6 0.25880444436031 0.181356713471135 0.581028262182095 0.274460702923135 0.153613105251458 0.536502535641712 0.356640648491355 0.0924311970614817 2.0 -0.0140892003594803 0.97100168852273 -0.0857747403309358 0.760575555362796 -0.0998639406904161 0.744408501152452 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ABCA7 -0.793421960058343 0.181385598802063 0.581028262182095 -1.13767369837073 0.0416389886203528 0.390826995201837 0.389472188938682 1.0 -0.119510723408713 0.751864114640305 -0.68259659561723 0.029548873185884 -0.802107319025943 0.0220815981122657 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BAD -0.359912735636696 0.181651081696727 0.58140222025402 -0.50998910789977 0.0487404397831894 0.404047580308211 -0.204152072763888 0.43818386322322 -0.0120151692338491 0.962701740657235 -0.216167241997737 0.353530304421764 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CRYL1 -0.686477202290877 0.181674663535148 0.58140222025402 -0.765074619013967 0.134033833450239 0.520900171021663 0.168403154961753 0.674997859030404 0.169650444257929 0.585594458981046 0.338053599219682 0.301117269547638 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POFUT2 -0.386016769352863 0.181722610990554 0.58140222025402 -0.431831152860142 0.133122468100995 0.519212049578983 0.26844986376808 0.343246661825797 -0.588492211996744 0.0285429932755446 -0.320042348228664 0.216383579618286 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ST18 -1.36140729015218 0.181863394914722 0.581676377918703 -1.41893378114249 0.162118626055437 0.5435530180671 False False False False False False False 0 insufficient_or_context_specific +BBOF1 0.339749894909945 0.181994284324571 0.581724145078947 0.349475896827932 0.170112435841544 0.550428163535097 True False False False False False False 0 insufficient_or_context_specific +ELMSAN1 -0.281563340643605 0.18199657582082 0.581724145078947 -0.493547442229477 0.0119033420837073 0.306601496403255 -0.215139037071509 0.460969734937169 -0.129144785257259 0.603982512933377 -0.344283822328768 0.181898032853241 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PKNOX1 -0.248746058377308 0.182081714407987 0.581724145078947 -0.358628459444669 0.0485302195673742 0.403450439521525 0.45536842736436 1.0 -0.318186993188289 0.337730132501224 0.0623106337786518 0.839540975270021 -0.255876359409637 0.395180938783054 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC180 0.342705609518734 0.182098721300049 0.581724145078947 0.46014506921247 0.0646813201109047 0.434440024660897 True False False False False False False 0 insufficient_or_context_specific +AC019205.1 0.432806019651394 0.182334713429492 0.582301846457524 0.391410027901834 0.228289427059505 0.60038155150582 0.04378177547539799 1.0 True False False False False False False 0 insufficient_or_context_specific +TMEM161B-AS1 0.275107101414878 0.182500023154114 0.582653536274913 0.399808817473691 0.0448965717384945 0.393650849907072 True False False False False False False 0 insufficient_or_context_specific +AC026202.2 0.733037390074203 0.182556024661586 0.582656139170806 1.22364140143562 0.0309396724508555 0.375031405408838 0.0248425613587764 1.0 True False False False False False False 0 insufficient_or_context_specific +LRRC2 0.789792359313232 0.182620536630625 0.582685894755556 0.886886945369359 0.136724770146438 0.523136620282319 0.5747067355243171 0.0595329350274947 2.0 True False False False False False False 0 insufficient_or_context_specific +EFNA5 -0.680691166104248 0.182840320433791 0.583020130035228 -0.217889807090492 0.659856738639465 0.872407073022888 -0.393020080738204 0.319547673789427 -0.765938884056101 0.0403841792886706 -1.1589589647943 0.0099189581977522 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FGD5 -0.381883080478288 0.182867908134312 0.583020130035228 -0.344906137794444 0.233432782456137 0.602697571243329 0.249990081072386 0.692845101861749 -0.0103992490295496 0.985295483391274 0.239590832042836 0.666232549689468 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GABARAPL1 0.649734333142969 0.183060788183185 0.583160626534234 -0.0828336858659334 0.862294685461174 0.957822965712685 -0.932379060066312 0.0398247226698036 1.44129769428415 0.0045170638987491 0.50891863421784 0.205038910314473 reversed False False False False False False False 0 insufficient_or_context_specific +PPARGC1B -0.465915679346504 0.183086131358101 0.583160626534234 -0.210363072126275 0.556491271032453 0.820941061653668 -0.35724177174956 0.651898598887457 0.513905840849107 0.366191398016536 0.156664069099547 0.824163417848841 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM129 0.433555610468658 0.183180598894356 0.583239072112971 0.206918239547725 0.513777628716508 0.798491683514042 -0.0113905812223659 0.976054723818235 0.0830657815456676 0.753171851512759 0.0716752003233017 0.812320116507902 partial_or_other True False False False False False False 0 cross_species_direction_conflict +YAP1 0.393726507732793 0.18331272288432 0.583303332199564 0.455385812038443 0.117692739520897 0.497239639401058 0.548400256596269 0.127164559740025 2.0 -0.376644883938296 0.116314030329043 0.0739084532607789 0.741409614817426 -0.302736430677517 0.172126954872279 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KMT5C 0.334896820729015 0.183713335080103 0.583734220425451 0.164121399258352 0.525867368556646 0.804676662787375 0.50563622313943 1.0 -0.0621708679190694 0.896912008682393 -0.917891169856884 0.016664800210118 -0.980062037775954 0.0177863121489145 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DRAIC -0.914530982990844 0.18375917162631 0.583734220425451 -1.00367756608304 0.142554336758364 0.528011532230573 False False False False False False False 0 insufficient_or_context_specific +PIK3AP1 -0.441715830954745 0.18376146545086 0.583734220425451 -0.5719088751933 0.0767818388773449 0.455668688469891 -0.0388764849357964 0.931049044353546 0.121628999856425 0.694340953150831 0.0827525149206285 0.815144433132181 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZBTB18 -0.480973357754598 0.183781145978915 0.583734220425451 -0.466828998025022 0.198580746188991 0.573943476119181 0.132166088288941 0.747752563561526 -0.291689598547747 0.33967781930739 -0.159523510258806 0.64859526869157 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GHR -0.357378042247843 0.183889490271857 0.583734220425451 -0.150576983442436 0.584003703671723 0.834132995585234 0.303627306918606 1.0 -1.12025559694326 0.007763761678421 1.39649623077525 0.0025648917783568 0.276240633831993 0.419171147373967 reversed False False False False False False False 0 insufficient_or_context_specific +RNASEH2C 0.431948667716075 0.183998499692452 0.583734220425451 0.451796447911689 0.16571221055373 0.545468009482397 -0.626228480908799 0.0825452834283036 0.134453900805056 0.687167712311402 -0.491774580103743 0.141391011251308 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GPATCH4 -0.554840672987282 0.184067461181721 0.583774182984864 -0.449042774931473 0.288975474112009 0.648310091921223 0.350071140941748 0.275983572678032 -0.899820116797864 0.0077838195144687 -0.549748975856116 0.0830241202651341 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADNP2 -0.27854623921304 0.184278007193693 0.584033411631749 -0.340300378935853 0.0983281463680491 0.478125555523304 0.002592343932535 0.993804153998224 -0.57216710183355 0.0182894934366263 -0.569574757901015 0.0255893308020278 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NEK6 -0.446794321717952 0.184297421805983 0.584033411631749 -0.297835269683989 0.381288368374846 0.717583349964639 0.729063650456105 1.0 0.112923119739875 0.709111204729034 -0.125226512352193 0.600242154485363 -0.0123033926123184 0.967418880563716 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MPST -0.431833451133855 0.184315147523867 0.584033411631749 -0.413743657384876 0.205462635012841 0.578666837313374 0.456236600736569 1.0 -0.396890920905268 0.258558071623988 0.598876164479487 0.0611054937429738 0.201985243574219 0.541548967858627 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM234A -0.42621857143908 0.184416990683015 0.584034556144819 -0.458026857193298 0.151072586807751 0.533690850143514 -0.143400531920742 0.690038981640459 0.226227596490193 0.410964931815711 0.0828270645694511 0.799954026091569 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANGPTL1 0.720866425018507 0.184453128755247 0.584034556144819 0.0129700914364892 0.980303778168867 0.994014064108846 0.7197299849492129 0.6431824240603461 2.0 True False False False False False False 0 insufficient_or_context_specific +LRRC75A -0.540277692225676 0.184579359388971 0.584055448620685 -0.267176495336547 0.511433337890428 0.796770426655916 0.823628505321774 1.0 0.472762255380388 0.202559296088674 -0.672846629071514 0.0455763632066194 -0.200084373691127 0.58553721002668 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MOV10 -0.356060917156744 0.184598695969618 0.584055448620685 -0.293376500954638 0.278714429746227 0.642056684302669 -0.135609004138539 0.680798649240649 -0.733066867357856 0.0143542471969097 -0.868675871496394 0.010388211914392 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP6AP1L 0.480724692516874 0.184685760387321 0.584155859247854 0.259281741293342 0.477943417287613 0.778545319644225 0.9550899538379459 1.80337763402484 0.0429342760774994 3.0 True False False False False False False 0 insufficient_or_context_specific +RFXAP -0.322353991417535 0.184872442713713 0.584571204004606 -0.218084770572137 0.383623579927429 0.719285696479096 -0.375733253760099 0.239105460690219 0.32688664562351 0.223676882843322 -0.048846608136589 0.885032422574932 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF180 0.298675014245051 0.184961302872788 0.584660764311743 0.524917270063502 0.0124858609161464 0.313114831651016 0.2593802693105799 0.0823935859756397 0.119166505931188 3.0 True False False False False False False 0 insufficient_or_context_specific +RPS27A 0.518353168327505 0.185063034193898 0.584660764311743 0.424488037360559 0.278565115725942 0.641950971352435 True False False False False False False 0 insufficient_or_context_specific +CARHSP1 -0.293418780100402 0.185475234047916 0.585646422550017 -0.261931220793445 0.238609289493619 0.606415397271769 1.00689154213276 1.0 -0.32974312338306 0.33919882164384 0.273204069799049 0.357047123824387 -0.0565390535840116 0.876273996010451 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC2A13 -0.277968666855053 0.18557313793069 0.585646422550017 -0.127351665387791 0.554983636306747 0.81985689549834 1.21788441894051 0.0123707633488523 -1.01375974435476 0.0137845671453651 0.204124674585755 0.667944965893879 reversed False False False False False False False 0 insufficient_or_context_specific +APMAP -0.577335865526812 0.185600770018219 0.585646422550017 -0.580187043699189 0.183584886959252 0.565541146173142 -0.158177525569432 0.688936764998849 0.526056629800168 0.0846041788973571 0.367879104230736 0.247431023668825 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCRN2 -0.47258180659211 0.185662538992997 0.585666294200197 -0.510616042856013 0.152464562840463 0.53585913930413 0.509410402569609 1.0 -0.750269505192341 0.0527911261423032 0.20076383147286 0.555142785786831 -0.549505673719481 0.119745271518884 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOLC1 -0.52052517870822 0.185736612636507 0.585724957053834 -0.510055967315116 0.195922465826201 0.571700325195908 0.478307680991515 0.492115800151573 2.0 -0.215757200885313 0.689120134926459 0.154531658739933 0.715348172256737 -0.0612255421453804 0.905903214090264 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BRD7 -0.275927594105427 0.185948526153317 0.586207123253411 -0.139567132115687 0.518042653970838 0.800840369846825 0.557154774743957 1.0 0.312438321439691 0.303350793900669 -0.273480262488326 0.28364055918928 0.0389580589513647 0.905691209127458 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RALB -0.335572102445351 0.186006187036905 0.586207123253411 0.0544262112354852 0.830772234128104 0.943790632272401 0.121660794012128 0.753444349195425 0.306409322925364 0.270106905591063 0.428070116937491 0.160448005828863 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IRAK3 0.37471260183424 0.186063663218561 0.586207123253411 0.223301949234873 0.433923825685002 0.751660242498796 0.134554226395573 0.0785905257898545 2.0 -0.721848789061699 0.246069987207612 0.623644581897257 0.216543991742707 -0.0982042071644415 0.876324893409141 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL359644.1 0.564150219346689 0.186120680413933 0.586207123253411 0.152943768141037 0.718337894349045 0.898496799968868 True False False False False False False 0 insufficient_or_context_specific +ZNF516 0.224514364625321 0.186167122965399 0.586207123253411 0.217815402944579 0.200727323079962 0.575734603933236 0.106254021437378 1.0 True False False False False False False 0 insufficient_or_context_specific +FHOD3 -0.679285821167181 0.186364831236612 0.586479847450418 -0.110054868054613 0.823903507220278 0.940306261942676 0.4225543971053761 0.4276236288445999 2.0 False False False False False False False 0 insufficient_or_context_specific +FREM1 -0.670299983119722 0.186564401217189 0.586583367495856 -0.737700498552611 0.14625399536456 0.532796338690088 0.567396712029686 0.434458336600881 -0.0106334312028424 0.987370083409442 0.556763280826844 0.388655565891942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ILF3-DT 0.41906231869314 0.186768807005022 0.58665603364206 0.0280975430929626 0.931949432608308 0.981045440677165 True False False False False False False 0 insufficient_or_context_specific +ACSM2A -1.03400328533621 0.186821533430737 0.58665603364206 -1.29383644798932 0.0964179895860894 0.476718312442311 False False False False False False False 0 insufficient_or_context_specific +LINC00884 0.645661933623809 0.18682638757027 0.58665603364206 0.232477311762947 0.62374534423449 0.85592713080683 1.41140013621631 1.0 True False False False False False False 0 insufficient_or_context_specific +INTS11 -0.240232986775064 0.186870683516369 0.58665603364206 -0.165425159688918 0.37090303545621 0.709933692593666 0.302536858886836 0.336344736712615 -0.170136770547531 0.518110416407796 0.132400088339305 0.66613947490803 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NAT1 -0.668595042400584 0.186970223039889 0.58665603364206 -0.828284666118643 0.0975885981592725 0.478125555523304 1.0733616206302 1.0 False False False False False False False 0 insufficient_or_context_specific +SLC27A4 -0.374333265497063 0.187032033457016 0.58665603364206 -0.192548078124907 0.51622256786732 0.799726369818831 0.363609741406886 1.0 -0.0297099296926967 0.947172925971506 0.108152026507266 0.726864878977221 0.0784420968145691 0.823276202435986 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP2C9 -0.881238357079262 0.187149501188747 0.586719211174894 -0.88372087150769 0.186247259762781 0.568159077889465 False False False False False False False 0 insufficient_or_context_specific +AC007920.2 0.434842569605687 0.187163317222679 0.586719211174894 0.428953766793879 0.194113750647627 0.571343735852293 True False False False False False False 0 insufficient_or_context_specific +PIK3R4 -0.309017728260429 0.187356356294265 0.586844239050912 -0.0545999920560577 0.819166685483014 0.937594977362923 0.503791814876082 0.254779790379232 0.106746001408436 0.77636917457778 0.610537816284518 0.134967683874357 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAH1 -0.386622198220755 0.187362979341692 0.586844239050912 -0.193984061448633 0.506182432244992 0.793608039538775 False False False False False False False 0 insufficient_or_context_specific +STRIP1 -0.229364579253797 0.187468949865517 0.586844239050912 -0.248858780904653 0.151087830030617 0.533690850143514 0.0877098445255888 0.81588759810184 -0.166760593037905 0.533516151370854 -0.0790507485123166 0.805998221009205 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIK2 -0.414084059695021 0.187607844938015 0.586844239050912 -0.419342312455833 0.182098540375481 0.56456240235188 0.452469759378211 1.0 -0.436073436483312 0.18857971321716 -0.133976806855122 0.658554259640841 -0.570050243338434 0.0749371678856138 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DPP8 -0.188712083528077 0.187840814763417 0.586844239050912 -0.0397669405205322 0.789699253146001 0.927193323483662 0.0340266022746546 0.918157951904821 -0.287493659574233 0.200570996484521 -0.253467057299578 0.285357387052383 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IL4R -0.390853614769759 0.187848465408154 0.586844239050912 -0.451702554368535 0.124108670037268 0.506117936752985 0.981088678672486 0.462709900438492 2.0 False False False False False False False 0 insufficient_or_context_specific +ZNF66 0.476050462471206 0.187859608275354 0.586844239050912 0.332523470088097 0.363639618425666 0.704883253447919 True False False False False False False 0 insufficient_or_context_specific +PCK2 -0.667421175773832 0.188046956889571 0.586844239050912 -0.749580786812589 0.13408555178431 0.520900171021663 0.532055709034745 0.0642261665211111 -0.239327217494481 0.322285455025229 0.292728491540264 0.265995264444029 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INO80E -0.378830322440284 0.188261867053787 0.586844239050912 -0.285578801479791 0.32270669990378 0.672877524535327 -0.0165931388707211 0.961618911505644 -0.277085815433296 0.234160912852302 -0.293678954304017 0.240249133044611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARL6IP4 -0.312621223891113 0.18833221860228 0.586844239050912 -0.315679343472265 0.183560795080975 0.565541146173142 -0.486746959700265 0.0314744856927262 -0.172099948437402 0.372276454994945 -0.658846908137667 0.0088333672976549 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CANT1 -0.485782851294916 0.188500394000554 0.586844239050912 -0.704248402998091 0.053209544639201 0.416631456505827 -0.0870729465159783 0.745995021322483 -0.292115592555276 0.154114143623718 -0.379188539071254 0.0866519301190438 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GAS6-AS1 0.613908162179634 0.188552282783633 0.586844239050912 0.624094428406584 0.182516334327367 0.564667601143233 0.7321950118274579 0.493574721252152 2.0 True False False False False False False 0 insufficient_or_context_specific +NBPF3 -0.392117836998972 0.18867587438572 0.586844239050912 -0.145212601741007 0.639709414513264 0.864573988534439 False False False False False False False 0 insufficient_or_context_specific +PPIL4 0.228410592587672 0.188824289934364 0.586844239050912 0.0809426996962597 0.641896685169975 0.864816711762523 0.8583000980599399 1.0 -0.0599800610529759 0.861279616670755 -0.134079664904241 0.578178749983302 -0.194059725957217 0.449628792460127 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FOSB -1.79316485766321 0.18898312131691 0.586844239050912 -3.45739240370286 0.0080114370091566 0.287862310479138 0.3694757120337051 1.0 -1.20255094566513 0.493702686712473 0.706610530906825 0.624107570631695 -0.49594041475831 0.746224181954427 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTO1 -0.275562408403605 0.18909918630916 0.586844239050912 -0.308007325985514 0.137523031060537 0.523810858054217 -0.0475897273041984 0.885130826731918 -0.15762408347824 0.484876296668573 -0.205213810782438 0.394930161064653 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CASC3 -0.284574490698591 0.189110977716992 0.586844239050912 -0.325917156557483 0.127802794834422 0.510744010936834 0.376364311181125 1.0 0.0575331428674337 0.85911292565266 -0.384666698893489 0.0979350016209224 -0.327133556026055 0.175922154109519 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIM3 -0.618285904254915 0.189133709975826 0.586844239050912 -0.753987081459186 0.0999925121098523 0.478125555523304 0.36024253036674 0.567178216966047 2.0 -1.47526364034359 0.0181287931645124 1.02980743626422 0.0577080394056011 -0.445456204079371 0.401510282050849 reversed False False False False False False False 0 insufficient_or_context_specific +TSC2 -0.307034702223018 0.189137684278724 0.586844239050912 -0.379368795854338 0.104122216324081 0.480263154193818 0.15773891319558 0.502664356471799 -0.187250812198044 0.325782525294587 -0.029511899002464 0.902763997160685 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAPPC10 -0.194260243296225 0.189191967578496 0.586844239050912 -0.142470488584546 0.337443391017271 0.685139869684682 0.553540826886098 0.44601245652768 2.0 0.0842219959775434 0.784947378045873 -0.0953528198368781 0.687403973890167 -0.0111308238593348 0.969955408199307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C4BPB -0.505545892256597 0.189286132300868 0.586844239050912 -0.635037325484278 0.0983279591833482 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +GIPC1 -0.408815460092875 0.189305544816902 0.586844239050912 -0.454869587845498 0.141490680662764 0.526923646040233 0.245529043678291 0.376559109740027 -0.695917473818867 0.0120210130294365 -0.450388430140576 0.0851444600275218 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOC2L -0.491173550530499 0.189325691224311 0.586844239050912 -0.518424786393617 0.162737329853473 0.544298760692042 0.507531612845525 1.0 0.172514988000603 0.572219713285171 -0.408972792834306 0.101646106719041 -0.236457804833704 0.368230288407249 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEMA5A -0.590873199493338 0.189337926972822 0.586844239050912 -0.131905917745434 0.770663622498399 0.920631444062254 1.12545493925396 1.0 0.181938944562295 0.704756194917616 -0.050606832235962 0.901314737008944 0.131332112326333 0.762158108262382 partial_or_other False False False False False False False 0 insufficient_or_context_specific +METTL17 -0.257429246456755 0.189351588745736 0.586844239050912 -0.229906157956958 0.235680765975853 0.604841401840801 0.0285087928994539 0.947911024617876 -0.73966279612153 0.0222373892084506 -0.711154003222076 0.0375893407233316 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL19 0.590111017248348 0.189728783181196 0.586844239050912 0.824679017384265 0.0731911443631769 0.451110392403048 1.08727555726586 0.016331061503259 2.0 True False False False False False False 0 insufficient_or_context_specific +NAP1L4 0.21381197479246 0.189738942879379 0.586844239050912 0.126402716981593 0.446403660588311 0.761287328136227 -0.224716667617239 0.448698338515123 -0.0987194509997712 0.704772046950294 -0.32343611861701 0.217512244499808 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COQ9 0.401972856494267 0.189876811583793 0.586844239050912 0.268736342717215 0.387698161849915 0.721289373182626 -0.113613260842795 0.736681306000668 0.363270143857857 0.155536938828105 0.249656883015061 0.35417011873624 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EFCC1 -0.52439408175776 0.189891558671326 0.586844239050912 -0.444483314571109 0.271523348142802 0.635606269407883 -0.623613951470528 0.160798809911724 -0.52806766057519 0.187617724015555 -1.15168161204572 0.0184003413698379 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SSTR2 -0.62351437304977 0.189895161782346 0.586844239050912 -0.546872058113035 0.255145497974837 0.619983007507096 False False False False False False False 0 insufficient_or_context_specific +TCF25 -0.305749721799182 0.189943903795073 0.586844239050912 -0.407058415449203 0.0739356579190223 0.452862231765951 0.143444600801636 0.402236180614004 2.0 -0.350318593868769 0.16796265374126 -0.288240259876394 0.20104596181873 -0.638558853745163 0.0192516471099365 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF33A 0.243758381881091 0.189978713588184 0.586844239050912 0.170721876061052 0.360673544747535 0.703177809506737 True False False False False False False 0 insufficient_or_context_specific +PSMA5 -0.313891037248352 0.189982346000759 0.586844239050912 -0.278096869427003 0.245761707080968 0.611033451076589 -0.256341907135312 0.363833474200257 0.0280054769922324 0.920671792437529 -0.22833643014308 0.370705855060016 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC092567.1 0.779213238354508 0.190152288294577 0.586919294801005 0.723457295644901 0.223302158689084 0.594234827022923 True False False False False False False 0 insufficient_or_context_specific +IPMK 0.348435854968076 0.190284846267799 0.586919294801005 0.3840115389036 0.147150247210508 0.532796338690088 0.0410855204825025 1.0 -0.405658474175285 0.310036261088563 0.574609693442223 0.0930949857093381 0.168951219266938 0.65588073835858 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF451 0.184549881459057 0.190354511459541 0.586919294801005 0.168708701383286 0.231994144365157 0.602112629352834 True False False False False False False 0 insufficient_or_context_specific +RNF152 0.299386334047242 0.190411611901168 0.586919294801005 0.311564644999509 0.171933678104087 0.552927199156574 0.49870647118519 1.0 -0.236328325224551 0.588698604296747 0.0485924887281783 0.903045597410523 -0.187735836496373 0.63118415906699 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EXOSC2 -0.389763395713912 0.190436691567281 0.586919294801005 -0.312267434132265 0.295907441859525 0.653323038718708 0.317648505554037 1.0 0.290989281156125 0.54502998065711 0.10308079317315 0.790095963285207 0.394070074329275 0.336907170095018 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBR1 0.217814904562513 0.190623087829163 0.586919294801005 0.0767426214543956 0.651239508364471 0.870022362306983 0.434639109037723 1.0 -0.201271707803093 0.615157287070527 -0.0493693563384668 0.89415111255265 -0.25064106414156 0.4616446475486 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NGLY1 0.375967741412146 0.190663118033229 0.586919294801005 0.390537485482031 0.173955032062595 0.555876885144334 0.0320584658051374 1.0 -0.333923973181559 0.194647842171679 0.299501414619433 0.179709475217335 -0.0344225585621263 0.900733723443326 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PHACTR1 0.370658324147668 0.190705418808637 0.586919294801005 0.388509656845234 0.169950585296829 0.550151003380263 1.3840344387889 1.0 -1.17623363708412 0.0152547183418752 0.525124248529403 0.183800184473818 -0.65110938855472 0.110180527690285 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IGLON5 -0.517013579706418 0.190718192374454 0.586919294801005 -0.566627572665298 0.148873758327331 0.533583468169136 -0.0382936673234586 0.950633272242692 -0.0012574169201343 0.997861089730202 -0.0395510842435929 0.93973769397189 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CREB3L1 -0.496184918585141 0.190729314307847 0.586919294801005 -0.625370642717575 0.0854793227184624 0.467503293000484 0.422954325203707 1.0 0.753606080504652 0.103485766357486 -0.468968028622688 0.234247516388556 0.284638051881963 0.519265116299169 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBX1 -0.301711850657468 0.190977169689758 0.587339632270452 -0.210431618366885 0.367179649880864 0.708317354196916 0.322149792667953 1.0 0.108373181587331 0.818971893422967 0.433389488875339 0.173424661625072 0.54176267046267 0.127369691583538 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYNDIG1 0.862471099139588 0.191135748571373 0.587506600723872 1.26919992573345 0.0666056705822452 0.436862290339161 0.0341988783447305 1.0 True False False False False False False 0 insufficient_or_context_specific +AL357793.1 0.535414167525079 0.191528034215068 0.588177133578445 0.492656768264407 0.229246635670495 0.600637150448404 True False False False False False False 0 insufficient_or_context_specific +RPS6KA3 0.270650891459647 0.191698285494468 0.588528786929512 0.297874397939019 0.146844138778666 0.532796338690088 True False False False False False False 0 insufficient_or_context_specific +PUDP 0.296197379700982 0.19234247964901 0.590163295592632 0.101074257449218 0.666660689777658 0.875295548708768 0.305945673550364 1.0 True False False False False False False 0 insufficient_or_context_specific +ALG1 -0.379546825109298 0.192527372075329 0.590558975703464 -0.418836653943633 0.148753963946884 0.533583468169136 0.274684986258455 1.0 -0.248461837168673 0.2756010051493 -0.293605064749303 0.142441401966666 -0.542066901917976 0.0230717935736413 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZCCHC10 -0.261637790380486 0.192650139963692 0.590763920341755 -0.238018438647631 0.235022412061219 0.604032771797066 0.712368518809222 0.0299263908810226 -0.711909011702756 0.016596131498921 0.0004595071064653 0.999241869102282 reversed False False False False False False False 0 insufficient_or_context_specific +SLTM -0.167830615033867 0.192820267613346 0.591113933060892 -0.136019235532406 0.293744261017192 0.652324662738756 0.6028369935878671 0.517536940855531 2.0 0.0998140896475817 0.72189463408318 -0.381489923422418 0.0855848027772051 -0.281675833774837 0.21822676580414 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIR34AHG 0.493986699412483 0.192942569832339 0.59120989205847 0.44851120397179 0.236295331926167 0.605241658048634 0.0996431407712026 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF124 -0.34619882578726 0.193075554822656 0.59120989205847 -0.043160408993914 0.866949369516083 0.958391272020028 False False False False False False False 0 insufficient_or_context_specific +ENTR1 -0.325977602574151 0.193286775767287 0.591685061916792 -0.302077564408594 0.228594983461556 0.600424738880655 0.0931740715415733 0.782144176160903 -0.10358504221862 0.690714797345042 -0.010410970677047 0.974248396582174 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP2U1 -0.515495703459632 0.193637816669855 0.592191366457868 -0.0468963816265887 0.909373099311504 0.971583494396145 -0.830535925475682 0.0419040261906775 0.882738010957797 0.0211029090688056 0.0522020854821152 0.900097135611324 reversed False False False False False False False 0 insufficient_or_context_specific +SGTA -0.313772074025721 0.193709522398253 0.592191366457868 -0.412637354915406 0.0833798661288435 0.464779732481256 0.6010889743199879 1.0 -0.0593076137239642 0.894159349094376 -0.0362705079765388 0.91793260891593 -0.0955781217005029 0.79051040585562 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VPS9D1 -0.422889517273767 0.193749870783357 0.592191366457868 -0.440220727817426 0.174236298685479 0.556001917747557 -0.42901443451484 0.164367830295177 -0.628604680626523 0.0359083847684528 -1.05761911514136 0.0058350677538059 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMUB1 -0.396733338964171 0.193857226559927 0.592191366457868 -0.310976134549162 0.320047422788414 0.672316094269812 -0.967934938784422 0.0488924381808764 0.656362930625072 0.109236763387687 -0.31157200815935 0.462329437213271 reversed False False False False False False False 0 insufficient_or_context_specific +TENM4 0.800345558345793 0.193896438636589 0.592191366457868 1.31367832735545 0.0344083956201126 0.37720666979567 0.415748147548353 0.0499775031522166 2.0 True False False False False False False 0 insufficient_or_context_specific +SDF2 0.342587293348606 0.194055861773278 0.592321997283108 0.233791334594825 0.37657819753091 0.714064764642842 -0.0541343718729039 0.853280537748676 0.262047075914506 0.197369827353113 0.207912704041602 0.332638572583452 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLA2G5 0.580613513299772 0.194160428545289 0.592330635883219 0.158204837568598 0.724261815719413 0.902378599287888 0.108007935541538 1.0 True False False False False False False 0 insufficient_or_context_specific +EFTUD2 -0.19907170609933 0.194184696277366 0.592330635883219 -0.211285713293713 0.167976521282671 0.547713437832748 0.0058572751200436 0.988784489626864 -0.131454547851422 0.630564538561541 -0.125597272731378 0.67918454812909 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IVD -0.309752478194292 0.194283102108694 0.592330635883219 -0.434895587602128 0.0670313421433454 0.436862290339161 0.965912161723907 1.0 -0.472875548297809 0.159351274500249 0.871277594456521 0.0118027247927626 0.398402046158712 0.195178042438772 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OFD1 0.245575272898799 0.194615992962134 0.592331237446358 0.0819475817317486 0.657505927304823 0.871691185476023 0.521618082494075 1.0 -0.265381794385167 0.626893606329124 -0.298656135266174 0.482310194558869 -0.564037929651341 0.229629189031308 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPE 0.282575593827804 0.194647523307181 0.592331237446358 0.17431502708088 0.427660736475855 0.747680419889399 -0.0377620400503036 0.905272363143444 0.356439201757304 0.093970436715718 0.318677161707 0.157349144240928 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MFSD6 -0.364651832871482 0.194652417991773 0.592331237446358 -0.484351438884826 0.0818700058625186 0.461990123942529 1.12192613393475 0.236632746680037 -0.212875435593638 0.758692312672979 0.909050698341117 0.308432749114559 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP2K2 -0.244306119053473 0.194653186219347 0.592331237446358 -0.228558168329455 0.226837222015602 0.599150046792164 -0.344128314797507 0.267279242354493 -0.162339417327331 0.558738794977201 -0.506467732124839 0.08409627547008 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CSMD1 -0.570152303354738 0.194715937911035 0.592331237446358 -0.475530568202849 0.289023040451924 0.648310091921223 False False False False False False False 0 insufficient_or_context_specific +AC107375.1 0.457146193019905 0.194745153924932 0.592331237446358 0.342267775379354 0.333225580547731 0.683012168398942 True False False False False False False 0 insufficient_or_context_specific +CHD9 0.186291784411592 0.194815118923414 0.592331237446358 0.213693856257928 0.13165698197927 0.517896578143491 0.4463217192944571 0.324141782339178 0.06278063229953501 3.0 -0.15508993193905 0.572198191260242 0.137901870970513 0.53318955380701 -0.0171880609685367 0.949455220911707 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AIMP1 0.252024358853945 0.194844325407388 0.592331237446358 0.233234074236776 0.230655706038751 0.601518427890281 -0.175725121012614 0.576119080251152 -0.0604893599000622 0.825715637439822 -0.236214480912676 0.377916846535421 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRDX6 0.48457213157507 0.195135220380119 0.592808690110488 0.336083258996399 0.367260828290959 0.708317354196916 0.181791584863987 0.0341192310910986 2.0 -0.0978582836946302 0.838400398534546 0.688494253381543 0.0519381891771047 0.590635969686912 0.102340682986795 partial_or_other True False False False False False False 0 cross_species_direction_conflict +YES1 0.2547302877027 0.195169824476611 0.592808690110488 0.237663985109476 0.226864777316848 0.599150046792164 -0.0558405859841149 0.890321753802564 0.0171195782312748 0.956415639213408 -0.0387210077528401 0.91174258412384 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SWI5 -0.450685417813358 0.195354345126937 0.59319849751228 -0.427945786686961 0.220667661283408 0.5925760086083 -0.237218488540069 0.424256029998086 0.511949075149431 0.0497499236701852 0.274730586609362 0.291162128940918 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IAH1 0.391373854010065 0.195429938042895 0.593240189907127 0.0694926721459008 0.814890114062216 0.935641141872961 -0.28631420052349 0.587210577046406 0.995177765574607 0.0305815284846226 0.708863565051117 0.114144949637606 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SMARCA1 -0.234140908076839 0.195534142319074 0.593240189907127 -0.101947124028328 0.561086580838854 0.822885417488071 -0.581883024954106 0.510160124281336 -1.03268340110575 0.198237302404241 -1.61456642605986 0.0724350416311629 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNGA1 -0.869746296074589 0.195536641492404 0.593240189907127 -1.09603086363311 0.0979647457920617 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +ZNF487 -0.51141529105759 0.19571367377097 0.593496893605023 -0.443940174621072 0.263874478176504 0.626379950271573 False False False False False False False 0 insufficient_or_context_specific +CBX1 -0.319010009234915 0.19573367906163 0.593496893605023 -0.356736443296677 0.145441927962716 0.532658823056677 0.077166968107853 0.849675164326135 -0.160125590185509 0.572575263653418 -0.0829586220776562 0.805998221009205 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C8A -0.457152133995956 0.195839563856576 0.593647463450396 -0.323716370861438 0.359247823063908 0.702743593654591 -2.00173557557814 0.0004522034763726 1.36940375089798 0.0040703474791481 -0.63233182468016 0.0956092391477017 reversed False False False False False False False 0 insufficient_or_context_specific +MEIS2 0.369308317983505 0.196545061505613 0.594947685821713 0.322340565590527 0.259144619359144 0.622885940784012 0.0891127036099393 0.4585700727518859 2.0 -0.5922151606454 0.128871924761007 -0.374482766127254 0.27822592751333 -0.966697926772654 0.0206212459289334 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PGM1 -0.347344081653917 0.196576602619909 0.594947685821713 -0.339322426211284 0.207323070349295 0.580306727663801 -0.596979174137786 0.0417759887687647 0.867694643337465 0.0054451042448924 0.270715469199679 0.294325762660054 reversed False False False False False False False 0 insufficient_or_context_specific +IPCEF1 0.478211379329328 0.196638806327836 0.594947685821713 0.802927004976277 0.0325646958454286 0.375031405408838 True False False False False False False 0 insufficient_or_context_specific +PLEKHM2 -0.198209050036045 0.1966476662644 0.594947685821713 -0.11966081035372 0.450395406101766 0.763947905803589 0.749362668642273 0.3547534961234871 2.0 0.358909279266265 0.324358136147792 -0.673147506717584 0.0425463636841992 -0.31423822745132 0.353671246088597 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPB41 -0.511318576349532 0.196662949755425 0.594947685821713 -0.632905120645335 0.105725276485308 0.483224012611202 -0.667398068555781 0.0333595877111666 0.492619362241388 0.0729066936551299 -0.174778706314393 0.542350095476212 reversed False False False False False False False 0 insufficient_or_context_specific +ZBTB46 -0.326738100435169 0.197046712449938 0.595510601566521 -0.128889924903195 0.626088191965545 0.856624485564009 0.6945045881653461 1.0 0.249802643460971 0.475377726439179 0.0833861647548038 0.786241638006412 0.333188808215775 0.275756364681384 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC22A15 0.38090270398023 0.19705892385996 0.595510601566521 0.496675059691791 0.0958877440089338 0.47569521889622 -0.126389805836278 0.873366340866357 0.209433271304327 0.691637210289212 0.0830434654680496 0.901500715374742 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NDUFB6 0.42898327988175 0.197086655056549 0.595510601566521 0.61651822074428 0.0629945634296953 0.432999502601999 -0.143487054968331 0.777386064339247 0.0141592130374617 0.974423910121543 -0.129327841930869 0.768605722344055 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PARD6G -0.428504023194844 0.197207231113887 0.595510601566521 -0.381033177856477 0.252856552466199 0.618991529980024 0.0520766793782307 0.933528287704014 0.206955354028392 0.603087584877972 0.259032033406623 0.567063628863742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCC3 -0.7874353346244 0.197312113943158 0.595510601566521 -0.952885362178527 0.114188320497825 0.4924007041452 1.08289355309112 1.0 -0.702146102639155 0.15217662703872 0.891309761211021 0.05153969347349 0.189163658571866 0.694938629100527 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TFIP11 -0.384922808843652 0.19735665797322 0.595510601566521 -0.246099133029406 0.415819972084976 0.737592755878248 -0.429393343944995 0.116187300331522 -0.182703826425943 0.446941440187486 -0.612097170370938 0.0294227714377973 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DTX2 -0.234337802852707 0.197462139527682 0.595561909891628 -0.408040861395897 0.0243124261342213 0.349408136686844 -0.178497392863025 0.639010697485095 0.297664706188647 0.294537969602593 0.119167313325623 0.725831244745298 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NID2 -0.563005399790127 0.197737619017067 0.595594596255438 -0.208450456597515 0.631374863377487 0.859914319858038 0.510101382800767 1.0 0.741821108264059 0.0255784429689985 -0.774750603635954 0.0138161372566436 -0.0329294953718949 0.925857252371527 reversed False False False False False False False 0 insufficient_or_context_specific +RNF207 0.543124370747582 0.197744825946362 0.595594596255438 0.351683548667926 0.401907961239037 0.73106743062194 True False False False False False False 0 insufficient_or_context_specific +UBQLN4 -0.4134274956117 0.197777073956564 0.595594596255438 -0.152919113484853 0.640116316487095 0.864640237429136 -0.155319314370589 0.520316567244718 -0.387813401697106 0.0622844818198569 -0.543132716067695 0.0229661088276189 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBX19 0.45625169052044 0.197884298177367 0.595661468258728 0.606246828620691 0.0922417742218444 0.472460751419842 True False False False False False False 0 insufficient_or_context_specific +TPM3 -0.305950830850729 0.197914418512182 0.595661468258728 -0.123617996749779 0.597436899188605 0.842154710498437 False False False False False False False 0 insufficient_or_context_specific +P2RX4 -0.374895850690629 0.198127419001505 0.596132598979166 -0.398894576277211 0.169974670678767 0.550151003380263 0.573674275735787 1.0 -0.318700779208573 0.237447613707625 0.0927967506228824 0.707994043097852 -0.22590402858569 0.362911437298446 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP2B4 -0.314438184535968 0.198643476449484 0.59726165977045 -0.0551799151297373 0.810118704754001 0.93324967646402 0.171448487460114 0.633484561356001 -0.269358889310498 0.330327995439636 -0.0979104018503835 0.769922401664505 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NR1H4 -0.495780625519559 0.198648323665144 0.59726165977045 -0.304111128112699 0.435627599382134 0.753375297997801 0.490109696903446 1.0 -0.362083181927773 0.267941395966082 0.373793898800622 0.192473227595584 0.0117107168728494 0.974248396582174 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BAG3 0.6043435540937 0.19867237631311 0.59726165977045 -0.0072348807869076 0.988323001189169 0.996718493722613 0.426176938408704 0.529132692611615 2.0 -0.270380759499436 0.581710611643553 0.645532536161001 0.103104287044216 0.375151776661565 0.362371006077626 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPB41L5 -0.385662752660803 0.198765199156371 0.597370615625667 -0.484813997296025 0.106034619199857 0.483261130274234 -0.109076183749071 0.840915112898908 0.453544680513532 0.204771561044583 0.344468496764461 0.382954015332693 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GYS1 -0.343020841322978 0.198873283114284 0.597390072904243 -0.193594291005679 0.478777226228147 0.779360153332836 -0.158990942968798 0.768779913577909 -0.957085863563678 0.0339578753921658 -1.11607680653248 0.0273197270267665 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NR2F6 -0.478011399474983 0.198884836735974 0.597390072904243 -0.405887272453552 0.280281188554804 0.642477283866194 0.325624562248096 1.0 -0.104311246855652 0.746387175967068 -0.144716722314088 0.561321440936571 -0.24902796916974 0.332496888140221 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PXDC1 -0.339102957501623 0.199038426826712 0.597527699016169 -0.34394769732865 0.19233406908142 0.570885363891703 0.351248573513289 1.0 -0.151657367430469 0.718011596911552 0.167590505287093 0.606513121661291 0.0159331378566235 0.969185940661951 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEPT8 -0.390462348667734 0.199043845182787 0.597527699016169 0.133774793735784 0.666385746367832 0.87511808324756 0.121608370735651 0.733046253677285 -0.10356766448844 0.71985842848994 0.0180407062472108 0.957198436297806 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTX2 0.309061073234074 0.199162636845613 0.597564011229562 0.242149251669772 0.318787201696206 0.670901806094448 0.9803339916768291 0.0426457490267358 2.0 -0.15168969700084 0.624389872884549 0.444016854159967 0.0749194721102918 0.292327157159127 0.254325029172108 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC4A2 -0.40050767630269 0.199225791554096 0.597564011229562 -0.160059671162408 0.616884191838306 0.852431712246777 0.28598559888635 1.0 0.107974015651271 0.72180480022544 -0.90973368812143 0.0038510740420548 -0.801759672470159 0.0092897696325408 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIF3B -0.280792281369605 0.200498142590641 0.60052748637503 -0.0186074943146078 0.931798057453665 0.981045440677165 0.157447709231457 0.634042231155187 -0.318539045043388 0.211649484347822 -0.161091335811931 0.580411485682836 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DGLUCY -0.285249023154108 0.200647208637449 0.600803524899088 -0.233006386891832 0.29477561715539 0.652324662738756 0.412817070154537 0.286084384898412 -0.153906885706049 0.641854634613426 0.258910184448488 0.472836836392786 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFR 0.194293715587027 0.200763731506503 0.600981989579148 0.296038074077263 0.0406536562894135 0.385820373303632 0.8550474574185859 1.11263270182366 0.0596537348030702 3.0 -0.0325351980911452 0.914797038067208 0.0314308682824807 0.893908278737451 -0.0011043298086644 0.996903220681512 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CENPC 0.208975246364257 0.200959972381988 0.600998553180442 0.173719343020054 0.289031597146543 0.648310091921223 True False False False False False False 0 insufficient_or_context_specific +SNRNP200 -0.220845248337207 0.200960299376202 0.600998553180442 -0.290575235511532 0.0906221923389277 0.472234212482528 0.978565573779828 1.0 -0.0561858986934649 0.862969457241543 0.37574232464776 0.100124132024495 0.319556425954295 0.181678224446525 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM41B -0.278144975789675 0.201003814521506 0.600998553180442 -0.279105099105576 0.199205113000168 0.575122356864606 0.458587972717166 1.0 -0.154785978048451 0.745995021322483 0.139862898241713 0.70410833194653 -0.0149230798067384 0.974248396582174 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAM1 0.377439793598623 0.201053882348297 0.600998553180442 0.299036512780716 0.312248130266946 0.664562035049465 -0.343678977630447 0.306828401090083 0.593861326589608 0.0545475095162114 0.25018234895916 0.414355256395578 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ITGB1-DT -0.43820522916824 0.201227417857742 0.601347035873774 -0.268722966227155 0.42566463305707 0.746291463934997 False False False False False False False 0 insufficient_or_context_specific +FAM214A 0.334969025362258 0.201487074984085 0.601719656002047 0.0734199671930947 0.786122256831726 0.926121604088118 0.952626411758658 0.115732248128606 0.120147972560923 3.0 -1.06369035905516 0.0132192763296099 0.562821448379313 0.112254139070399 -0.500868910675844 0.168141982608943 reversed True False False False False False False 0 cross_species_direction_conflict +AP003063.1 0.485402384474456 0.201523082366285 0.601719656002047 0.303433392146853 0.414337006074235 0.736663818217135 True False False False False False False 0 insufficient_or_context_specific +FOXK1 -0.24987900712088 0.201580393653826 0.601720609611844 -0.281093482258743 0.148955824925842 0.533583468169136 0.274196951776909 1.0 -0.476014689807948 0.0825452834283036 0.0646074076966758 0.80304293369629 -0.411407282111273 0.108801845066307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SERPIND1 -0.594317844722864 0.202016900108088 0.602853146224191 -0.292001597939032 0.541093695149668 0.813507447752299 -0.917662298767765 0.0772941532712822 1.26724792068831 0.0153966619099055 0.349585621920546 0.459720084382167 reversed False False False False False False False 0 insufficient_or_context_specific +APLNR -1.01396690988474 0.202147804512747 0.602883734490867 -0.764643750649508 0.344780284921506 0.69073818751447 False False False False False False False 0 insufficient_or_context_specific +LNX2 -0.338037630866943 0.202181556154771 0.602883734490867 -0.207026384971748 0.440383898753497 0.756815882099629 -0.0241996593349756 0.949750205790923 0.190584835621577 0.448998957924272 0.166385176286602 0.553397724125437 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGEF3 0.477370949622693 0.202265171848391 0.602883734490867 0.735629251083173 0.0406914666543224 0.385820373303632 0.472940789527513 0.0536748508904133 2.0 -0.373623479014581 0.225949997926762 0.425949933682036 0.111887302056422 0.0523264546674549 0.87272829030532 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CCDC28A 0.510722082559284 0.202398212497247 0.602883734490867 -0.0082136659335734 0.983455928629723 0.99451887511202 0.250602685190092 1.0 -0.453500412361451 0.198871127019193 -0.242726268996171 0.435880216928654 -0.696226681357622 0.0473736748509004 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AIFM2 -0.453787349454263 0.202402683137817 0.602883734490867 -0.380935947454618 0.290724697985116 0.650001487250975 -0.470621731314376 0.0734411340762764 -0.144698590221586 0.534688835450744 -0.615320321535962 0.024300672580268 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INHBA 0.842940896084143 0.202504584376176 0.602883734490867 0.785822515790966 0.23328549217173 0.602697571243329 0.470281355484695 0.3409979408934131 0.0852366527509411 3.0 -0.446895222441512 0.149394353934129 -0.0836006109757572 0.773698435551437 -0.530495833417269 0.0755503708556374 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPL27A 0.436324510459342 0.202655273130146 0.602883734490867 0.79426775483532 0.0195917349028852 0.330467462546779 True False False False False False False 0 insufficient_or_context_specific +BRF1 -0.311208939346704 0.202787505946031 0.603089293295228 -0.466754414996505 0.0469519214508823 0.399450754777127 0.224282866898029 0.47133043795982 -0.531913371695304 0.05153969347349 -0.307630504797275 0.265128216727675 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIMS2 -0.445365733286036 0.202838613420284 0.603089293295228 -0.772639227374351 0.0182559499904449 0.32629129734252 -0.857304188248038 0.0188222038975691 0.746737336418363 0.0247030060160753 -0.110566851829675 0.745102741120791 reversed False False False False False False False 0 insufficient_or_context_specific +SLC41A2 -0.403518801429723 0.203069642588258 0.603563805533091 -0.289378909630322 0.362341382954629 0.704011836811736 -0.665000533780263 0.130899869637614 0.142909200628893 0.724867048404529 -0.52209133315137 0.196081456563688 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADGRV1 -0.612029493401334 0.203115194934674 0.603563805533091 -0.547364498772151 0.263452467507209 0.626379950271573 False False False False False False False 0 insufficient_or_context_specific +TBL1X -0.281985689520453 0.203245710892449 0.603563805533091 -0.289539007395804 0.191017689509844 0.570352026539856 0.526087014099377 1.0 0.0497031341434806 0.868855565568195 0.0250944133433976 0.916891833145961 0.0747975474868781 0.758343930299781 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZBED5 0.285669139338189 0.203309723272609 0.603563805533091 0.162174745870574 0.471016430058526 0.774850649510427 True False False False False False False 0 insufficient_or_context_specific +AC106791.1 0.503572076849265 0.203335468554711 0.603563805533091 0.425259398397956 0.285491322278148 0.646550274691695 True False False False False False False 0 insufficient_or_context_specific +UBE2G2 -0.238538194357318 0.203398372806094 0.603563805533091 -0.129090670798214 0.483269177734198 0.780666906162311 0.902159247952427 1.0 -0.318106910487121 0.291817695422367 0.226818622542192 0.384971445107528 -0.0912882879449285 0.763150425995697 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARL8A -0.345083975551543 0.203505326280885 0.603711501790837 -0.0954029723263852 0.738160559255116 0.90727580728935 0.22751345138043 0.4492365224944 -0.336150780619315 0.180547656347711 -0.108637329238884 0.706438412341802 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GOLIM4 -0.233202501311515 0.203625090301272 0.603808739061544 -0.0614710409555175 0.748719089082042 0.910671976140056 0.212837928335939 0.386966283877942 -0.199284841886677 0.339414185935664 0.0135530864492615 0.958216666061011 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACOT9 -0.293856402582097 0.203652483405774 0.603808739061544 -0.411493202280447 0.0718729663620566 0.446899163045108 False False False False False False False 0 insufficient_or_context_specific +EBP -0.52154322774568 0.204029632159047 0.604525707500404 -0.554729141040862 0.174338078485087 0.556091067264518 -0.48397769780402 0.175808797321143 0.947567260950377 0.0106244022687197 0.463589563146357 0.157896524677059 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PEX1 0.246082020055717 0.204113521200176 0.604525707500404 0.224151740802067 0.248157732824933 0.614136532744356 -0.277302575062684 0.353550870438419 -0.0807825303025327 0.764415058964956 -0.358085105365216 0.187778767803111 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HAND2-AS1 0.338495342625532 0.204123332756104 0.604525707500404 0.220014977073204 0.406429066358758 0.733961461951707 0.415245658667282 1.0 True False False False False False False 0 insufficient_or_context_specific +MVB12B -0.219730843113261 0.204254661287374 0.60457547347129 -0.248825514274135 0.146597381596414 0.532796338690088 -0.139722215896129 0.743976099655532 -0.268175767610795 0.406589813606466 -0.407897983506924 0.234037998927662 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TOMM40 -0.312071065674748 0.204565510030551 0.604855708155356 -0.157633827833941 0.520899061692525 0.801463897948394 0.172035686095063 0.366476875467888 2.0 -0.164686917303504 0.694035064010413 0.0789890714548132 0.822093972796588 -0.0856978458486905 0.824153930186941 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MED9 -0.342917327339667 0.204860190782465 0.60534953660265 -0.0655990835491101 0.816575242168685 0.936230700610385 0.341425707574732 1.0 -0.281659230472268 0.596454233907932 0.642445710422008 0.112391546544262 0.36078647994974 0.408379922039658 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLYAT -1.03465422414124 0.205108515490647 0.605913739941312 -1.20767498060583 0.136778049740283 0.523136620282319 -0.906253254805631 0.0810931983929462 1.67641367648251 0.0044289923760352 0.770160421676883 0.104599625986172 reversed False False False False False False False 0 insufficient_or_context_specific +LYRM2 0.408871809583255 0.205332281109175 0.606132280239339 0.361151653173222 0.26156241597639 0.624330278962413 0.0203255939454246 1.0 -0.388841722968863 0.300161201299016 0.138912829020763 0.6713392888627 -0.2499288939481 0.46605519304985 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPL13 0.400782389162113 0.205334757136988 0.606132280239339 0.49079088885867 0.119359112845294 0.499900248662619 0.68790429178978 1.0 True False False False False False False 0 insufficient_or_context_specific +SRRM2 -0.306946546963527 0.205354723093021 0.606132280239339 -0.425210531372089 0.0714039208442626 0.44579195673941 0.112938942919803 0.717666734516757 0.103723663679899 0.681760294294269 0.216662606599702 0.394133886986746 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAFG 0.37471315212112 0.205567501865243 0.606215719866877 0.150988851012884 0.620399781979819 0.854153589708151 -0.44604082725456 0.117172726940726 -0.409372990101702 0.110052124829686 -0.855413817356262 0.0091231161185644 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SEC24C -0.253783459638932 0.205669894344766 0.606215719866877 -0.421307980653049 0.0316517869453609 0.375031405408838 0.7385243331526959 0.3525801393816789 2.0 -0.0249148566588178 0.933277309558909 0.0022704098055817 0.992734420924669 -0.022644446853236 0.927177905708643 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTSC -0.474742334387322 0.205693370387907 0.606215719866877 0.042658575391996 0.90478084210788 0.969884267885983 0.713329125750493 0.5806923730767221 2.0 0.13811856771455 0.74310326338478 -0.188718117218106 0.560929363202034 -0.0505995495035558 0.897710141575316 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FLNB -0.422554031720219 0.205830040254639 0.606215719866877 -0.861834620361372 0.0081489011743079 0.287862310479138 0.5582671262039011 1.0 -0.187559715613458 0.444781551391726 -0.101891731416398 0.634582061607417 -0.289451447029856 0.183128207011902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL590999.1 0.592525879505453 0.205900626808742 0.606215719866877 0.594350180030169 0.205575593485687 0.578666837313374 0.0212333872470553 1.0 True False False False False False False 0 insufficient_or_context_specific +ANAPC10 0.208970757398023 0.206049568435775 0.606215719866877 0.0641859952937196 0.703050485101917 0.891640364000942 -0.393493610591211 0.616511684944781 0.150367160893731 0.811478278547012 -0.24312644969748 0.731194032782345 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TPI1 0.433203369588831 0.206080416304615 0.606215719866877 0.114968399587882 0.734187780374366 0.904977889122883 -0.351992877909718 0.3116848038668 0.121034062564565 0.702664448406005 -0.230958815345153 0.470386197493985 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GNAI1 0.371393656542212 0.206090536667908 0.606215719866877 0.277087757139647 0.348221372114622 0.693734774979578 0.276476990822878 0.4954288774891671 2.0 -0.511383075893646 0.197582990499566 0.14797165179914 0.679611196462262 -0.363411424094506 0.31812376267788 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KDM2A -0.162333940869863 0.206106193307025 0.606215719866877 -0.12042451587166 0.351539717538288 0.695960310851161 0.373638418107128 0.629598988233953 2.0 -0.0150377386825603 0.962850315611004 -0.466890517081991 0.0483478835564302 -0.481928255764551 0.0504985446124394 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIVA1 -0.405739937276621 0.206172828781546 0.606215719866877 -0.26106735687448 0.422687859536061 0.744144334629103 0.542697327165245 0.368514200778526 -0.400350955361562 0.380345328313157 0.142346371803683 0.822378917549632 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOC3L -0.410523089350003 0.206204407199017 0.606215719866877 -0.372863137686914 0.254709941403253 0.619879203544451 0.168278277226833 0.788283708800902 -0.155652809695337 0.738714937413563 0.0126254675314964 0.984616069026163 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATF2 0.240210320715674 0.206262322722924 0.606215719866877 0.222926876788647 0.242286300563595 0.608928228474458 -0.213576731812367 0.476044186670897 0.254345219335305 0.296462026858219 0.0407684875229386 0.893795711634063 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MINK1 -0.268578965229264 0.206275550675807 0.606215719866877 -0.261136304771299 0.219657695822267 0.592069212484543 -0.290957180466283 0.306170942181649 -0.246927089218629 0.316761417831332 -0.537884269684912 0.0504747545196111 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UROC1 -0.904780610354193 0.206291361863681 0.606215719866877 -0.673470960613578 0.360192764883667 0.702811903833258 -0.713748822478926 0.0982306692466134 0.911999245997664 0.0293858043039421 0.198250423518738 0.6351603677909 reversed False False False False False False False 0 insufficient_or_context_specific +GRHL1 -0.55722499632055 0.206301674699914 0.606215719866877 -0.660678274519871 0.130816597712428 0.516515197699258 0.625892470811239 1.0 False False False False False False False 0 insufficient_or_context_specific +OSER1 0.429364445283835 0.206491705138029 0.606560278950315 0.272767066369374 0.427448852860054 0.747680419889399 0.0186070801916007 1.0 -0.110920345721601 0.771518108449609 0.458398757980501 0.100184943926142 0.3474784122589 0.238689921016844 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KIAA0513 0.481032628960528 0.206630217254209 0.606560404213356 -0.0182518261083001 0.963178884831442 0.989935386867005 False False False False False False False 0 insufficient_or_context_specific +DFFB 0.286240206537243 0.20668191787545 0.606560404213356 0.110582693571748 0.630886469188803 0.859692738990112 -0.0956932112575286 0.798361240228936 -0.701849963351785 0.0220897494880379 -0.797543174609313 0.0206382943196543 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLA2G12A 0.424164890334208 0.206706226023835 0.606560404213356 0.182857281623668 0.581243724712073 0.833234384997972 -0.467996429918415 0.207672815509816 0.170147134999137 0.603474871661136 -0.297849294919278 0.382330014536178 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZSCAN25 0.248091121430184 0.206944087211138 0.606869006043246 0.240587215567505 0.219686576503268 0.592069212484543 -0.312897137035975 0.533649036430834 -0.270499810273883 0.505501453732661 -0.583396947309858 0.187839069207331 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLCG2 -0.423433444141115 0.206958865302938 0.606869006043246 -0.837479819820772 0.0055914560985824 0.265300960238175 0.290325477618423 0.72485469237235 -1.02687076477551 0.101995886036925 -0.736545287157084 0.323541505399288 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IL16 0.917159464598495 0.207074982068716 0.606869006043246 1.13916695793595 0.124697717267896 0.507064043928032 1.24391029258912 0.9703968516222929 0.0534804584053202 3.0 -1.30947711930476 0.0217360296660551 0.778946551472988 0.103025106484495 -0.530530567831776 0.262659986620826 reversed True False False False False False False 0 cross_species_direction_conflict +AC007262.2 -0.374735203515321 0.20738467126923 0.606869006043246 -0.379400054766871 0.20169053760749 0.576305465780752 False False False False False False False 0 insufficient_or_context_specific +LRIG3 0.318439291532168 0.207443662646662 0.606869006043246 0.429091714872234 0.0895400541561234 0.470746198832535 0.0693025079522228 1.0 -0.245017383896707 0.58826887757278 0.0410568687827163 0.919228163577521 -0.203960515113991 0.610511477494799 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DCAF16 0.274051811045182 0.207581418899643 0.606869006043246 0.0946552132024486 0.661294611721128 0.87272681909059 True False False False False False False 0 insufficient_or_context_specific +SYNPO2 0.502318870471429 0.207697045745544 0.606869006043246 0.523181415670675 0.188047350499072 0.56929178900529 0.753935816348117 0.0946965687812802 2.0 -0.0187858225873922 0.977528461326785 0.0371967854999005 0.940940065875699 0.0184109629125083 0.974649884355066 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BID -0.712163604118023 0.207831514468406 0.606869006043246 -0.880566248419253 0.114092049073396 0.4924007041452 -0.504639832457085 0.198871127019193 0.126703401793143 0.718038383732061 -0.377936430663941 0.292050589662553 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIP5K1A -0.215975804297249 0.207889969591472 0.606869006043246 -0.221945054452211 0.193855494058551 0.570967444223168 0.697809496169952 0.768644303855916 2.0 0.0772446366285806 0.848726472302442 -0.379271873778 0.176249037617341 -0.30202723714942 0.320960521871704 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COPZ1 -0.310923199806964 0.207965235619017 0.606869006043246 -0.540721975589492 0.0203895702347757 0.332725011651872 -0.0572520477217119 0.865711176141888 0.464414812063848 0.059530562901108 0.407162764342136 0.10628174684105 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NCOR2 -0.340590321461828 0.208127904201294 0.606869006043246 -0.421336904516431 0.114215696576207 0.4924007041452 0.301457876928302 0.385137812734967 0.182957484134115 3.0 -0.0274406622551565 0.935754187183527 -0.407709874495942 0.0853966460281747 -0.435150536751098 0.0817279022591044 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF141 0.473012453488843 0.20813546354026 0.606869006043246 0.429734086231225 0.25191831440294 0.618547340340987 -0.201523620395141 0.574413633154496 0.188266505935657 0.512354235960545 -0.0132571144594848 0.971660897253608 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RAB9A 0.378055547976136 0.208175035645966 0.606869006043246 0.395435346878163 0.188815865997733 0.569351952070621 0.417102577833419 1.0 True False False False False False False 0 insufficient_or_context_specific +PLPP5 -0.476872231987487 0.208200886623773 0.606869006043246 -0.0658970375136363 0.864477184505102 0.958391272020028 -0.090044143761246 0.829010029691934 -0.525383373525018 0.0868215912391125 -0.615427517286264 0.0634027218292734 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HYI -0.583345726911686 0.208305860759682 0.606869006043246 -0.645990988718661 0.161151552812363 0.543541307772207 0.650010724745401 1.0 False False False False False False False 0 insufficient_or_context_specific +MARC1 -0.349549551982765 0.208452376393872 0.607121231559995 -0.286577304369657 0.311852079728809 0.664337047357073 0.499093534945982 0.67451520358137 2.0 -1.18808355560484 0.0173898455738389 1.07113310152789 0.0209829450154013 -0.116950454076956 0.805465131680725 reversed False False False False False False False 0 insufficient_or_context_specific +C4ORF19 -0.498902906687543 0.208507443231345 0.607121231559995 -0.601914291434641 0.128482750468099 0.511894671487619 1.07691479951466 1.0 False False False False False False False 0 insufficient_or_context_specific +LINC02542 0.568644832246049 0.208684797656596 0.607470111292622 0.598755152987264 0.187852291234706 0.56929178900529 0.0122388635714383 0.575051188862566 2.0 True False False False False False False 0 insufficient_or_context_specific +DCAKD -0.310105933982634 0.208823498031566 0.607597303094223 -0.281665793124751 0.256034858731797 0.620670263344767 0.355589302325444 0.511803509181416 2.0 0.294561412842976 0.448706517317112 -0.202876803265375 0.516655725454482 0.0916846095776011 0.812973835386775 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC068580.4 -0.684900116885839 0.208903104191431 0.607603023155131 -0.972570582361746 0.0526257064183242 0.415884886500499 False False False False False False False 0 insufficient_or_context_specific +CC2D2B 0.38242397521352 0.209320425591776 0.608649147176527 0.640780112453283 0.0416835144547524 0.390847731450511 True False False False False False False 0 insufficient_or_context_specific +SULT2A1 -0.851495037347504 0.209460288073893 0.608888139175155 -1.03172234208068 0.125906961296108 0.507996233320616 False False False False False False False 0 insufficient_or_context_specific +MTF1 -0.371797652304545 0.20972015682295 0.609308039553303 -0.182428679132502 0.553696887236291 0.81967635101525 -0.0943774450570457 0.888426793702172 0.0978420526945255 0.846045514926817 0.0034646076374797 0.996046272772552 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HIST1H2AC 0.661355712102501 0.21012362943386 0.609679124369065 0.333693620051152 0.51555440582833 0.799350732708873 True False False False False False False 0 insufficient_or_context_specific +TMEM51 -0.31868622122483 0.210185799347729 0.609679124369065 -0.0653461067776518 0.805273255264005 0.932449553528993 -0.5728186088676 0.123021345733282 0.365921915934706 0.252852255963919 -0.206896692932894 0.555982851394206 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XPO7 0.211295035621658 0.210211650657841 0.609679124369065 0.355050832736779 0.0340029119312627 0.376543096535729 0.2785944249957 1.0 -0.143316756656751 0.647142562488837 0.146355310317469 0.554701821264794 0.003038553660718 0.992760846097494 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GAS2L1 -0.531846748201473 0.210238245519713 0.609679124369065 -0.634468440986216 0.12998831339891 0.515364856502325 -0.165735475298185 0.591450115454601 -0.555358258767635 0.0394299824619596 -0.72109373406582 0.0190626030269611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDCA7L -0.545132122567609 0.210252101896928 0.609679124369065 -0.685650997442271 0.10790883094372 0.483985317376294 False False False False False False False 0 insufficient_or_context_specific +EBNA1BP2 -0.825623323284517 0.210323693779279 0.609719263844489 -1.0476342309495 0.107778257838868 0.483943630910814 -0.109467015793263 0.702415242790261 0.105305151937398 0.646005891410354 -0.004161863855865 0.988314184511743 partial_or_other False False False False False False False 0 insufficient_or_context_specific +D2HGDH -0.312803587470529 0.210390879631327 0.609746611898862 -0.347914246529539 0.161116707455226 0.543541307772207 0.457785515377519 1.0 -0.227103805015509 0.578461099236858 -0.133761113503107 0.698271549630013 -0.360864918518616 0.299252950358875 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF740 0.468980014408882 0.210506402773314 0.609746666798533 0.358132831538378 0.337307986431145 0.685057785656405 0.366197221899546 1.0 True False False False False False False 0 insufficient_or_context_specific +TMCO3 -0.167719919096415 0.210657366345419 0.60991593477135 -0.058617016398492 0.684159046385285 0.882766419515653 0.679539646510271 0.0379936751874299 -0.257304159856569 0.310146900905995 0.422235486653702 0.158191320437955 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM193B -0.197439624156628 0.210966436558571 0.610409327811836 -0.255548172939765 0.0945462012874249 0.474551164587418 0.5617792449479979 0.0745397189163431 2.0 -0.29597889701692 0.327654096706271 -0.356420940940446 0.179885021706627 -0.652399837957366 0.0314004828266949 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPHA7 -0.861369286359751 0.211455161605108 0.610643646164135 -0.428312021523457 0.548761937107415 0.816365047001981 0.542566345894901 0.0494612528890035 -0.702913009508532 0.0110463352042473 -0.160346663613631 0.538941807163739 reversed False False False False False False False 0 insufficient_or_context_specific +NUP85 -0.197810632499661 0.211469498818861 0.610643646164135 -0.215553157872801 0.170630635827998 0.550991514163622 0.28250780458353 1.0 0.321537561207602 0.270361512914888 -0.531990575727535 0.0445965212029279 -0.210453014519933 0.443529638632892 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRRC2A -0.225959650911957 0.211667715132569 0.610643646164135 -0.282953057388744 0.113285359923823 0.4924007041452 0.228034661337456 0.412448068065036 -0.27289124049708 0.245503949114496 -0.0448565791596235 0.876583989226777 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZBTB17 -0.443475195849372 0.211711438128041 0.610643646164135 -0.473382148085939 0.179489575238162 0.562663579383762 0.595524659730486 0.441437570499208 2.0 -0.392254144305638 0.23984976158523 -0.529859956493155 0.0815945145561383 -0.922114100798793 0.0143600855461494 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NBAS 0.210192896564479 0.211721626053606 0.610643646164135 0.298381297778617 0.0688134575930371 0.438727346175897 0.9442063213342551 1.0 -0.265082306979476 0.349050879242194 -0.138111697610824 0.578739454646383 -0.4031940045903 0.12186816534382 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PIK3C3 0.225067888610582 0.211730229646683 0.610643646164135 0.205123552824297 0.254224414251366 0.619121653608424 -0.13129842458648 0.689319692062457 0.268691771992095 0.282136968703857 0.137393347405615 0.626588048733308 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ABLIM3 -0.56247984145081 0.211758839557057 0.610643646164135 -0.592495463334536 0.187630241508354 0.56929178900529 0.5668496256285239 1.0 -1.32333537750081 0.0116379362912768 0.79042659574688 0.0703518890503919 -0.532908781753934 0.211654570755817 reversed False False False False False False False 0 insufficient_or_context_specific +CORO2B -0.369468764457499 0.211903137430984 0.610643646164135 -0.386343498853862 0.191797358660292 0.570665777497258 1.05069731251122 0.5228346146356311 2.0 -0.130421305999842 0.763974060480545 -0.0875528056015724 0.799067850199327 -0.217974111601414 0.539821382220508 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE2I -0.195094369025199 0.211932768658601 0.610643646164135 -0.276189022719822 0.0743585204293496 0.452862231765951 0.644255067706004 0.00191569837250527 2.0 False False False False False False False 0 insufficient_or_context_specific +LUC7L2 0.459769527889054 0.211983107910072 0.610643646164135 0.420491715367417 0.252815914605579 0.618991529980024 0.101236687259068 0.0406523247322462 2.0 -0.417599399625207 0.194329151817234 -0.443186770093439 0.125519267975672 -0.860786169718645 0.0150451173382639 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HAO1 -0.799572837901405 0.212055275621379 0.610643646164135 -0.90419654558971 0.155431661750536 0.539558215777 -0.947254237871612 0.126380044440331 1.281268657142 0.0318907698878728 0.334014419270391 0.56730045646012 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLEC2B 0.613427891142596 0.212083717912233 0.610643646164135 0.731277284157127 0.137760684299826 0.523810858054217 0.0282930814511709 1.0 True False False False False False False 0 insufficient_or_context_specific +DDX31 -0.328333507866409 0.212094427928254 0.610643646164135 -0.254060738302538 0.336486663547923 0.684909618997295 0.321575558069732 0.348153051515085 -0.773954999202119 0.0180789990673848 -0.452379441132387 0.163817465843902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KEAP1 -0.402016833566704 0.212289891474222 0.610643646164135 -0.741919491023276 0.018538470861439 0.327267058068343 0.452273490049469 1.0 -0.344529430883597 0.154871551121583 0.209344855331289 0.321595639017921 -0.135184575552308 0.558367411215417 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMARCA4 -0.238665501586793 0.212315416481801 0.610643646164135 -0.273547780646741 0.147466424997973 0.532796338690088 -0.111060688380583 0.668294357839891 -0.242409235856658 0.230680094421152 -0.353469924237241 0.105055826582113 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NKAP -0.346354747351296 0.212517916941599 0.610643646164135 -0.287282401162497 0.308707187988925 0.662330926800867 0.269488735430894 1.0 0.0417571527133291 0.949750205790923 0.078352437733002 0.864694784658741 0.120109590446331 0.819420250660826 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFE2L1 -0.439635168262638 0.21261327774553 0.610643646164135 -0.559297711125991 0.10505231734879 0.482830329046451 0.221074325173088 0.330568013072306 2.0 -0.148003539871571 0.63835245579401 0.229145232081071 0.357402198448824 0.0811416922095008 0.780160419920717 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TERF2 -0.22030026647401 0.212661230698753 0.610643646164135 -0.119421807479054 0.51524304788729 0.799314452426005 0.126543676381923 0.719441319499475 -0.639526226551244 0.0310833233870947 -0.512982550169321 0.0872179798562124 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZEB1-AS1 0.395418147067595 0.212676510030548 0.610643646164135 0.401394445609432 0.206063609405002 0.578776160707106 True False False False False False False 0 insufficient_or_context_specific +UBR4 -0.206944590098812 0.212724695074037 0.610643646164135 -0.235607284310627 0.151775075265047 0.534368029741253 0.659785119063196 0.0944255161932565 2.0 -0.257258073948669 0.316290652250643 0.022079428811576 0.931942990277106 -0.235178645137093 0.312567192566721 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STK10 -0.353989439862272 0.212936065999484 0.611084257902299 -0.0901592577064164 0.756807852558386 0.914454644719928 0.604020006448069 1.0 -0.0716669642246974 0.922603819289352 -0.82173963709649 0.106104090122557 -0.893406601321188 0.115257480779504 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XYLT2 0.396962684781295 0.21306982951211 0.611301972823058 0.176542955357331 0.571793581072235 0.827343161164732 -0.288810221557632 0.281200815214397 -0.176542406248225 0.447527867855669 -0.465352627805857 0.0700984237016613 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARRB1 -0.465865419116722 0.213301089378947 0.611799212622365 -0.480088922486026 0.19925492277654 0.575122356864606 0.6431431304777641 0.281289499181349 2.0 -0.681505418685196 0.0274929723905575 0.25096971084283 0.335428912559622 -0.430535707842366 0.118941592988843 partial_or_other False False False False False False False 0 insufficient_or_context_specific +JPX 0.247413001437403 0.213404578310007 0.611929803855798 0.414221641450538 0.0334551200021055 0.376280667109215 0.105817085960328 1.0 True False False False False False False 0 insufficient_or_context_specific +OTUD7A 0.262747759959624 0.213639801261732 0.612280544751707 0.290748241831764 0.169199332962689 0.548819218869452 0.0686900597916639 1.0 True False False False False False False 0 insufficient_or_context_specific +TMEM53 -0.597259475774633 0.213738802748163 0.612280544751707 -0.995018634941889 0.0286818841058027 0.367950586134951 0.183663959978853 0.753315603238527 2.0 0.420775633992452 0.465060658282007 0.139064184644209 0.763276683201078 0.559839818636661 0.263911150014541 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TARSL2 0.237078721709131 0.213824643997283 0.612280544751707 0.353472066402967 0.0675414161577876 0.43786261079484 0.331396590416543 0.09606642333399999 0.0711160006224256 3.0 -0.540220273049937 0.478262020577928 0.609009416273662 0.28721580070223 0.0687891432237256 0.926670859088778 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAP3K4 0.257867050612985 0.213895026672906 0.612280544751707 0.307073919061345 0.134251229938628 0.520900171021663 0.7081098796245551 0.542032525510719 2.0 -0.442241069643157 0.194275784091598 -0.505266511603658 0.102234291175216 -0.947507581246815 0.0137183103444898 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARHGEF17 -0.285857652082435 0.214048566627464 0.61244573616606 -0.0043192663489872 0.985366735075431 0.995307821007743 0.357254796989983 1.0 0.347924862182224 0.358582194856629 -0.366238205102444 0.258057477710361 -0.0183133429202203 0.964336910007263 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM104 -0.32084714378156 0.214108733456992 0.612451912175269 -0.607799583245794 0.0138907475287329 0.314756631908661 0.0184810684093985 0.969651685100975 -0.223549136865771 0.494514819584632 -0.205068068456373 0.573721200175838 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMLHE 0.27757186196823 0.214401525003747 0.612791364642544 0.414107942935706 0.062792954691885 0.432999502601999 True False False False False False False 0 insufficient_or_context_specific +MCRIP1 -0.271084934235251 0.214534296418013 0.613004898939481 -0.274539992722752 0.207511076196337 0.580525156990176 1.00811233722112 1.0 0.0756054468099017 0.83030983837404 0.0828499085403506 0.753097505295345 0.158455355350252 0.563275581380712 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYFIP2 0.687024745842667 0.214630520074106 0.613113915298272 0.834349019429125 0.13440341488245 0.520900171021663 -0.924793229487738 0.0794094024550154 0.562239712686807 0.208589517138224 -0.36255351680093 0.438233521381342 reversed True False False False False False False 0 cross_species_direction_conflict +ZNF107 0.262400799381102 0.214776156706031 0.613363987693339 0.132561345603357 0.530720901253397 0.807748490043731 True False False False False False False 0 insufficient_or_context_specific +FZR1 -0.455291941540838 0.21486384579296 0.613448481309375 -0.408505505147916 0.270549645130095 0.634531964851516 0.742404625359519 1.0 0.149165428251508 0.727190108818436 -0.798700626299541 0.0273333709802598 -0.649535198048033 0.0776440326533431 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB3D -0.41582284664106 0.214925465820861 0.613458520718208 0.0082021471713699 0.983520150787126 0.99451887511202 0.263662774913197 0.559782776498489 -0.165192218753815 0.646617599137965 0.0984705561593823 0.822212581776642 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RHOT2 -0.35910690792007 0.214985676522132 0.613464533167749 -0.295429725461943 0.308424953953356 0.662330926800867 0.473841263622074 1.0 -0.495356197917155 0.0514822849404761 0.0063639342515347 0.980613792462185 -0.48899226366562 0.045570579991042 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC017002.5 0.788158950649783 0.215053344534748 0.613491816157219 1.28182692931723 0.0683712102860189 0.438244764077482 True False False False False False False 0 insufficient_or_context_specific +NRXN3 0.630795372556213 0.215305941830457 0.614002068610328 1.01092641934274 0.0516072982077406 0.411222531681 0.259771020881626 0.275417443277408 0.0765836177503371 3.0 True False False False False False False 0 insufficient_or_context_specific +GKAP1 -0.370885437701369 0.216030861670218 0.614785400947214 -0.384621145450847 0.198530922877872 0.573943476119181 -0.383274517730418 0.272242332270522 -0.089444645542394 0.785344660767513 -0.472719163272812 0.143932650001431 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IQSEC1 -0.28122708283535 0.216180051520266 0.614985950109195 -0.420072749949649 0.0587698745733512 0.427941109491281 2.04317299607642 1.0 0.0068823058128889 0.985527007557646 0.12160975433505 0.630654097711886 0.128492060147938 0.642996249604373 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM132D -0.969377312026139 0.216281822999652 0.614985950109195 -0.295707774551881 0.707984188551278 0.893638108503159 False False False False False False False 0 insufficient_or_context_specific +MET -0.610361546039683 0.216285299398863 0.614985950109195 -0.303698109537398 0.546346137465738 0.81552807024429 -1.05910326641779 0.009820152621725 0.714988695145444 0.0393462191412386 -0.344114571272347 0.299814818822732 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF22 0.368026168825437 0.216620052963422 0.615410592907224 0.283230954602638 0.342206803107901 0.689130402583821 0.419392560464339 0.431805047472983 0.0263236221397074 3.0 True False False False False False False 0 insufficient_or_context_specific +NME6 -0.33543542316458 0.216657406953145 0.615410592907224 -0.31780961034834 0.243798787798189 0.610315684654444 -0.42170555268222 0.516893350455639 0.0332169469821553 0.956415639213408 -0.388488605700065 0.498948051728217 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GABPB2 -0.263437144346663 0.216716857778846 0.615410592907224 -0.427829126849107 0.0280638983591153 0.364899801570861 0.247298476216772 0.0101083457051314 2.0 -0.357542484812592 0.21668835556984 -0.63627754525182 0.0258302488325242 -0.993820030064411 0.0056240409791027 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NIFK 0.4184290589195 0.21677600888503 0.615413041626284 0.364868068810545 0.280861365767667 0.642821222582925 -0.0915821405835343 0.849457504351744 0.447314434025986 0.163552133970238 0.355732293442452 0.308746492536557 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FMO3 -0.631641808233354 0.216883335624975 0.615552219765721 -0.636415132615591 0.213564530244932 0.586275171691626 False False False False False False False 0 insufficient_or_context_specific +PTPRS -0.369507959625327 0.217340816023894 0.616684852346216 -0.494387354921675 0.0861095648907631 0.467677448123587 0.662233285127452 0.269356593744248 2.0 0.594576950043463 0.0328452296486504 -0.766708022317409 0.0080112576849898 -0.172131072273946 0.501188119697174 reversed False False False False False False False 0 insufficient_or_context_specific +EVC 0.295620461736122 0.217670099367562 0.617453226524106 0.218434036630942 0.363331710075343 0.704765682869143 0.7080116198879641 1.0 -0.0883709429112665 0.806528014426297 -0.309935864331481 0.230498379965613 -0.398306807242748 0.153749035214437 partial_or_other True False False False False False False 0 cross_species_direction_conflict +APLF 0.289910037739093 0.217806672987123 0.617508822072515 0.416286827165268 0.0792912967440876 0.459078388240937 -0.26709666446036 0.700539517707229 -0.0854144327558946 0.885110611748431 -0.352511097216254 0.553397724125437 partial_or_other True False False False False False False 0 cross_species_direction_conflict +OCLN -0.355129513944503 0.218200323312349 0.618139552500591 -0.407562916703702 0.154558057500841 0.538529955163527 -0.855367852439709 0.112344529772296 0.998906730251469 0.0373738919866842 0.143538877811761 0.780737509200391 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPAT2 -0.952544273473032 0.218204784255513 0.618139552500591 -1.73547271866142 0.0139363379907351 0.314756631908661 -0.954680633651008 0.029005255238903 0.56514230098773 0.129992217729412 -0.389538332663278 0.309311746049473 reversed False False False False False False False 0 insufficient_or_context_specific +DIS3L2 -0.163940008155849 0.218437542159171 0.618140683181076 -0.0413442730148703 0.759270062051242 0.915406319729464 -0.173263989506649 0.684618554469955 -0.108456033838386 0.752530142134153 -0.281720023345036 0.425570285641061 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SORL1 -0.637246398319459 0.21844443977866 0.618140683181076 -0.606212182763211 0.242813603452553 0.609516411139337 0.895989795529255 0.773303079959641 2.0 0.515582741722184 0.542888424064452 0.0969365192556806 0.884042308558433 0.612519260977864 0.39798537732422 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTF3C1 -0.230087603954685 0.218503182157656 0.618140683181076 -0.409229788909103 0.0218556910160935 0.344406545892411 0.309479217851051 1.0 0.113131600796764 0.72139298419685 -0.0059740804300367 0.983472411971598 0.107157520366727 0.699667099534851 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHF21A 0.346729675061369 0.21857537219954 0.618140683181076 0.50577925774797 0.0644280260273758 0.433921581835015 0.503792980615574 0.0713497991453141 2.0 -0.394551584337552 0.286903705465802 -0.482469668463867 0.141821091039445 -0.877021252801419 0.023327515635463 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAN1 -0.29717314388023 0.218591603745386 0.618140683181076 -0.118072348887556 0.632204801177604 0.860473275161544 0.0137951524471679 0.972404639115102 -0.495711318169966 0.0792824084136033 -0.481916165722798 0.117565819260088 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SAFB -0.193519209849295 0.218723913069248 0.618140683181076 -0.184319572512203 0.242008524955759 0.608802057364402 -0.417287895543374 0.0631124148366772 -0.442895107815068 0.037191057257431 -0.860183003358442 0.0034959033898189 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBRG1 -0.219884606164666 0.218820156948246 0.618140683181076 -0.225733640506693 0.206348038997487 0.579266842790605 0.6616653560110201 1.0 -0.391916461188366 0.164088124622486 0.356646732300618 0.149669046840667 -0.0352697288877478 0.907954211724921 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTF2A2 0.300523928911335 0.218840457425565 0.618140683181076 0.109951110907494 0.647243962072181 0.86855377695836 -0.294214990601524 0.267024025859728 -0.03290353384003 0.902552393611689 -0.327118524441554 0.178994249633 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SNX6 -0.211836454450036 0.219169411031638 0.618794142509603 -0.13767310674647 0.429393743013138 0.748355750863769 0.227236094376793 0.525073663158882 -0.451974226710994 0.120699661148693 -0.224738132334201 0.480599431365285 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MLIP -0.541747580457833 0.219224889860052 0.618794142509603 -0.0005210932770669 0.999111004480311 0.999584382194933 False False False False False False False 0 insufficient_or_context_specific +LSM6 0.393287850628283 0.219256382565677 0.618794142509603 0.159126805182342 0.616999729587977 0.852431712246777 -0.392007897053175 0.14835660142537 0.143039605416551 0.544464025957991 -0.248968291636625 0.315264659216967 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HAGH -0.435497621824887 0.219426419925396 0.618805736983134 -0.418981116126668 0.238483796603084 0.606415397271769 -0.200960830351394 0.658767193482548 0.797763636624574 0.0385460466722301 0.59680280627318 0.115609848279306 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HCFC1 -0.3437395441282 0.219482779199202 0.618805736983134 -0.334621817295034 0.232311195050159 0.602195334480623 0.333099064250075 1.0 -0.0307201034547192 0.932558334579471 0.213220472043761 0.362440793377367 0.182500368589041 0.47810321819474 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIB2 -0.398668340375431 0.219693481900323 0.618805736983134 -0.550119966212483 0.0811866706039841 0.461068439742811 0.379778518921424 1.0 -0.266538621817135 0.422978176083302 -0.360651765038732 0.200613157370499 -0.627190386855867 0.0480316515174267 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DOCK6 -0.313991448570772 0.21982767995035 0.618805736983134 -0.193292677598818 0.451063280014175 0.76417299589051 -0.324365326949585 0.424256029998086 -0.579866688798599 0.101585047302208 -0.904232015748184 0.0261757082056618 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOMO1 0.480886666730471 0.219879314494188 0.618805736983134 0.607644889129762 0.128154031825331 0.511356866217627 -0.15062183007959 0.677860015872792 -0.0842832127686231 0.779845539688281 -0.234905042848214 0.433605421007462 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C2CD6 0.500991215389432 0.220021842658906 0.618805736983134 0.371025581353599 0.373636352147314 0.711968837980936 0.731970950581338 1.0 True False False False False False False 0 insufficient_or_context_specific +TGFB1 -0.405578045221366 0.220141032836523 0.618805736983134 -0.436292832810403 0.182709275953806 0.564873948907844 1.00223268978268 1.0 0.593209602926044 0.0668147870024948 -0.166078257543586 0.548695818819053 0.427131345382458 0.153164698983959 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DGKI 0.652408823908482 0.220171786985768 0.618805736983134 0.627220818591963 0.238548220610808 0.606415397271769 0.0266346818737475 1.0 True False False False False False False 0 insufficient_or_context_specific +NUCKS1 -0.154329717872408 0.22018002606795 0.618805736983134 -0.120094114270569 0.344742241575246 0.69073818751447 -0.124729677384859 0.68614406247997 0.473674480291442 0.056007816618294 0.348944802906582 0.165684750828936 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCSK6 -0.591184449501653 0.220197683471113 0.618805736983134 -0.763729746814259 0.110851656638361 0.488469027874715 0.496743254257317 1.0 -1.34601208027669 0.0018856555800233 1.13419389412759 0.0043411408218517 -0.211818186149102 0.507979726353779 reversed False False False False False False False 0 insufficient_or_context_specific +DNAJA3 -0.291203326513966 0.220198252874184 0.618805736983134 -0.484863178134729 0.032209885782298 0.375031405408838 0.334272953302492 1.0 -0.344902249273745 0.369649684210199 0.621853453572547 0.0683357758574533 0.276951204298801 0.421878149771101 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKFN1 0.547361504102858 0.220343083906483 0.618962174103942 0.274452795089824 0.52446437167574 0.804371707750212 True False False False False False False 0 insufficient_or_context_specific +VCP -0.17812317845437 0.220383002942863 0.618962174103942 -0.244759257724218 0.0800523687508169 0.460059526331928 -0.0795367931063802 0.836933962693437 0.286341294102927 0.296212934090321 0.206804500996547 0.47810321819474 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PNN -0.255996027654859 0.220429794907257 0.618962174103942 -0.223987613460348 0.284047612547663 0.645043543745796 -0.0200604080906649 0.949371758075901 -0.772087056280264 0.0051268112190904 -0.792147464370928 0.0066929447478196 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCB7 0.252390846280552 0.220549684703779 0.619001234331983 0.310553527486752 0.127565902759298 0.510166970201769 0.0371744289842545 1.0 -0.0479389950131659 0.902911268270029 0.276513994059669 0.275414737719696 0.228574999046503 0.415349605399949 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ELP6 -0.291236516563618 0.220584403424514 0.619001234331983 -0.371038178740452 0.117306435443452 0.496998934756005 0.359324508790497 1.0 -0.255660246352882 0.605810517343222 -0.478092116320945 0.225441660257634 -0.733752362673827 0.0992047712408819 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PER2 -0.53650830063656 0.2206195912854 0.619001234331983 -0.909483155410486 0.0360969964690636 0.37720666979567 0.8051029392515809 1.0 0.247365706664256 0.628482003762105 -0.237263865272587 0.561321440936571 0.0101018413916691 0.985382269856691 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KHDRBS3 -0.468591590095511 0.220740787985058 0.619136893428193 -0.0884057311012177 0.815968644291063 0.936230700610385 -0.275395350573583 0.375079835934748 -0.119479159033684 0.66454316692564 -0.394874509607267 0.160347311037742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IL1RAP -0.492587889283402 0.220804766302107 0.619136893428193 -0.914887192410312 0.0180319435944783 0.32629129734252 0.8116156120374909 1.0 -1.44535255605664 0.0055830573429901 1.71919473633389 0.0021396096451283 0.273842180277247 0.498773371965971 reversed False False False False False False False 0 insufficient_or_context_specific +LMO7 0.212823543803833 0.221119683785683 0.619136893428193 0.171424555724334 0.327653359875699 0.676889991422347 -0.645475044516991 0.16082658328128 0.132796348716231 0.754350383199834 -0.51267869580076 0.223301394602426 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLEKHG3 -0.303869618588884 0.221165510716207 0.619136893428193 -0.452368829549596 0.0496914691463839 0.40534943521819 0.4209524509112729 0.493932294586756 2.0 -0.0601065268355018 0.901577906130256 0.103122052135411 0.76487523923077 0.0430155252999089 0.917064991174959 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBXN7 0.224942088393514 0.221230175135245 0.619136893428193 0.264666259075165 0.147286972829809 0.532796338690088 0.3730038184781529 1.0 -0.152622949397241 0.594093355400225 0.0859547171462444 0.71985842848994 -0.0666682322509971 0.804464118541942 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NXN -0.389014230791907 0.221252810346684 0.619136893428193 -0.634372062354295 0.0334386537506222 0.376280667109215 0.311018612628289 1.0 0.803070677752475 0.0161197207148762 -0.395305101447347 0.12850673715884 0.407765576305128 0.163454775744959 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLGLB1 -0.479069774205478 0.221291098082799 0.619136893428193 -0.459569422109033 0.24089192022504 0.608162815336196 False False False False False False False 0 insufficient_or_context_specific +APBB1IP -0.503667310843355 0.22134932234509 0.619136893428193 -0.697554957872991 0.084587636774667 0.465302662671366 1.30523145044604 0.0619600068930613 -0.578557133961281 0.248585869215701 0.726674316484761 0.274792867370414 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COMMD4 -0.32673660661387 0.221372404510228 0.619136893428193 -0.44596362064263 0.0852373386803256 0.466771691798173 0.3074124471875579 1.0 -0.20713568210545 0.411628843880654 0.0363823008218508 0.880403710620426 -0.170753381283599 0.450564127698631 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM131L -0.304744547786607 0.221385598162505 0.619136893428193 -0.277411533215367 0.265481254780619 0.62822323708046 0.343122340185998 1.0 0.0061819658135118 0.992788933773383 0.0595120244769487 0.900217493371686 0.0656939902904605 0.901500715374742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC27 -0.267022553086028 0.221395763043506 0.619136893428193 -0.125864783448628 0.566355464967083 0.824113119711934 False False False False False False False 0 insufficient_or_context_specific +LEAP2 0.622253788469791 0.221430281263957 0.619136893428193 0.721353183758777 0.157814127986706 0.54150197051792 -0.841550560893645 0.175099670205399 1.07820826766668 0.0576233826078703 0.236657706773036 0.694003370802058 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAU2 -0.254324637324531 0.221536291000988 0.619269303783011 -0.41625115922441 0.0365682812933816 0.377876708853838 -0.144534150917242 0.642597649597255 -0.603184236809753 0.0277895275422278 -0.747718387726994 0.0156616586964539 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALG6 0.367186455962264 0.222072782934847 0.619842078687204 0.418869225399716 0.163935357327723 0.544850245278 0.0163446951353399 1.0 -0.571213127399346 0.375872209667794 0.790026682766696 0.109712092150086 0.21881355536735 0.705157829940129 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM167A 0.336233302722992 0.222105866305093 0.619842078687204 0.508065116832327 0.0588294592277901 0.427941109491281 0.0194938837155152 1.0 True False False False False False False 0 insufficient_or_context_specific +SEMA4C -0.40498906928432 0.222152152467549 0.619842078687204 -0.320323651688757 0.344464909682724 0.69073818751447 -0.307634574594513 0.415605940026351 -0.377195168279904 0.239615881413648 -0.684829742874418 0.0553273692927881 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GMDS-DT 0.201489669133467 0.222403129702996 0.620378399842598 0.298751051636507 0.0647668686130188 0.434440024660897 0.0654308324393105 0.0993536702208615 2.0 True False False False False False False 0 insufficient_or_context_specific +MARK4 -0.232040118876735 0.222544468204125 0.620608688668556 -0.29982573881737 0.101873509081299 0.479137456027696 0.0070049095506545 0.985586590209939 -0.269216460888203 0.283878281432221 -0.262211551337548 0.331555635731116 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COG6 0.287227609635442 0.222721400984874 0.620868658128427 0.496863441798439 0.0365432909785148 0.377876708853838 0.0481640998276383 1.0 -0.495072428005616 0.151692782958579 0.0526425701716891 0.877872898258553 -0.442429857833927 0.166123894556194 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF263 0.371729689220301 0.222828461016225 0.620868658128427 0.0919912426110995 0.76074114442098 0.915734238148068 0.5510386500015021 0.402609724885301 2.0 True False False False False False False 0 insufficient_or_context_specific +PCED1B -0.363695223828374 0.222847499721079 0.620868658128427 -0.0006164576936278 0.998395857674443 0.999257679999277 -0.0260866421298831 0.954691325868045 -0.0859611266064363 0.789783847223173 -0.112047768736319 0.754482659240912 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIR122HG -0.810351896092102 0.222940249755179 0.620868658128427 -0.964493558516481 0.147715758701743 0.532846198833773 False False False False False False False 0 insufficient_or_context_specific +PIAS4 -0.294599338035104 0.22302471292695 0.620868658128427 -0.262655129407346 0.279576985637073 0.642114507827558 0.143702626044888 0.713431673907784 -0.363888550365716 0.215644351533232 -0.220185924320828 0.505854438408791 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VTI1A 0.230191330538181 0.223173554640554 0.620868658128427 0.28978960172052 0.121284810880819 0.503433670515718 -0.255028584465756 0.441498486717447 -0.500956573095218 0.0836014439321775 -0.755985157560973 0.0234750098498919 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RBM6 -0.144391492831751 0.223202329108079 0.620868658128427 -0.161227875139628 0.168689497085413 0.548101773166091 -0.0979546038075334 0.699390873816789 0.157093747334618 0.423564320418637 0.0591391435270843 0.797519997761548 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UFL1-AS1 0.40913263594928 0.223253474312458 0.620868658128427 0.550939886069414 0.0967158930628834 0.47738494574938 True False False False False False False 0 insufficient_or_context_specific +FYB2 -0.742509232149426 0.22328455151673 0.620868658128427 -0.794846867924441 0.191305051556298 0.570403483290424 0.3774061154582679 1.0 -0.536613290014889 0.418941545140387 -1.06847970808458 0.0893657345670305 -1.60509299809947 0.0280172459740103 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WIPF2 -0.164773918507226 0.223728867635372 0.621940332936877 -0.0933309726802035 0.490925665370392 0.785332299239484 -0.698903038509722 0.0895610205678827 0.359316916803886 0.303859927587938 -0.339586121705837 0.360278802665464 reversed False False False False False False False 0 insufficient_or_context_specific +SF3B1 -0.211443770287887 0.22392264493644 0.622248166445313 -0.281965661540163 0.0928155360310214 0.472689102082201 0.0268012197183213 0.945779519921482 -0.0337947158243212 0.912828480726403 -0.0069934961059998 0.984689765572988 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FCN3 0.938995746539645 0.224026687570639 0.622248166445313 0.544110601278661 0.478601090219813 0.779193571401817 True False False False False False False 0 insufficient_or_context_specific +CAND2 -0.405979734999698 0.224029373286437 0.622248166445313 -0.32112757783926 0.34196570298268 0.689130402583821 1.14898360250859 0.253312804231991 -0.856913577191091 0.239891024691281 0.292070025317496 0.796285168098851 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL359915.1 -0.986662570291917 0.22418873703945 0.622332909033041 -0.894063852521514 0.274242259599914 0.637623822254105 False False False False False False False 0 insufficient_or_context_specific +SLIT2 0.432928656728638 0.224223753169321 0.622332909033041 0.488949095945547 0.167108211736526 0.547439742091029 0.323605432088009 0.3538503322875289 0.202647781231187 3.0 True False False False False False False 0 insufficient_or_context_specific +PLEC -0.367726052546908 0.224392597316823 0.622406722094687 -0.252782750956256 0.419337555465391 0.741229852771405 0.414444531046334 0.533444823581615 2.0 0.239336589408518 0.43278340701235 -0.846009397825605 0.0078385748951665 -0.606672808417087 0.0390584644465845 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KANSL1L 0.222429057278855 0.224520422491401 0.622406722094687 -0.0212744758872568 0.907731484365868 0.971364079260221 0.0734986604416224 0.829010029691934 -0.274180055136819 0.248421151336012 -0.200681394695197 0.438233521381342 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHKG2 -0.43717590600583 0.224555538821321 0.622406722094687 -0.185269350273357 0.617438369424733 0.85250682148546 -0.065992557319132 0.911205409548353 -0.459561602956708 0.245455170235624 -0.52555416027584 0.220368618448333 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TLE3 0.318438435475793 0.224611505774909 0.622406722094687 0.403758953105488 0.132721279123779 0.518983148534855 0.785252872775586 0.374864210321163 2.0 -0.180848891561096 0.559782776498489 0.311287365422406 0.210045019021179 0.130438473861309 0.639697984928692 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GLYATL1 -0.711089315440723 0.224625217943548 0.622406722094687 -0.763970496170744 0.191625368118449 0.570552915001293 False False False False False False False 0 insufficient_or_context_specific +MAEA -0.267926278341649 0.225191806187417 0.623217585773721 -0.366987753104419 0.0922709790672366 0.472460751419842 0.546805661656359 0.468679706475353 2.0 -0.116417875564076 0.64876414120596 0.135274278374147 0.501648190332319 0.0188564028100712 0.939802624314014 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HAUS5 -0.358075635003658 0.225449310564301 0.623586970271111 -0.44758154845785 0.125403802583782 0.507759097984276 0.0348323538048518 0.964510570781438 -0.726804506679229 0.172358489833166 -0.691972152874377 0.251615726365561 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DVL3 -0.330721874192528 0.225463783064135 0.623586970271111 -0.276978318491053 0.314034307761098 0.666635985340959 0.216749088909829 0.468845290715915 -0.14014136664003 0.571266719743327 0.0766077222697986 0.793426024315336 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LAPTM4B -0.348844078749608 0.22550246755968 0.623586970271111 -0.460857027523105 0.100512299632723 0.478125555523304 -0.197593659804588 0.485043156887165 0.424679441811796 0.0774466242472505 0.227085782007209 0.355449604460031 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGAP6 -0.389248494752334 0.225687072157393 0.623816550783789 0.149269987205299 0.635863026088676 0.8619131890415 0.331078610209533 1.0 -0.12497278739014 0.769231397253366 0.632570498112836 0.0524014625971923 0.507597710722696 0.12788469270795 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM214B -0.408674162490917 0.22570365826805 0.623816550783789 -0.389776088336804 0.250284600078342 0.616672648883528 0.273128650430328 0.392819804119807 2.0 -0.158448992727908 0.604101754500267 -0.457062822840036 0.0729523926579751 -0.615511815567944 0.0321406638843243 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01687 -0.867745313049519 0.225870066912135 0.624057928195541 -1.04137466435846 0.141780862132083 0.526995437876627 False False False False False False False 0 insufficient_or_context_specific +ADAMTSL2 -0.407927453601537 0.225956566360285 0.624057928195541 -0.461502314645724 0.162943184347283 0.544298760692042 0.334762954930758 1.0 0.391423656188937 0.509197645821205 -0.109717877541987 0.840709977042864 0.28170577864695 0.600045557868288 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MLYCD 0.51926079282434 0.226074797480379 0.624057928195541 0.169332959463041 0.697233781887818 0.888803059281445 -0.668736300907797 0.128600360629023 0.64432557677503 0.101370082051278 -0.0244107241327666 0.958499884527045 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARL16 -0.429023619354699 0.226164026018813 0.624057928195541 -0.371108654993602 0.300051104231514 0.658405125798708 0.585932771331978 1.0 -0.0178477863191345 0.971220331487005 -0.211908344497406 0.528061353170304 -0.229756130816541 0.547659460684113 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STAT1 0.268372709613558 0.226306740294582 0.624057928195541 0.250529788686826 0.260366312448565 0.623061542799626 0.701725136128771 1.0 -0.10286158173538 0.752556985603511 0.0758559679417811 0.772677215661194 -0.0270056137935986 0.928500936767574 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HSD17B14 -0.394168071874533 0.226344769940422 0.624057928195541 -0.425798619508054 0.190387445577551 0.569920796826702 False False False False False False False 0 insufficient_or_context_specific +IRF3 -0.283907213169659 0.226359111842693 0.624057928195541 -0.393658567029083 0.0908351950522758 0.472234212482528 0.0908959605344661 0.779202984999491 0.106559497958649 0.6713392888627 0.197455458493115 0.439980437675298 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LPXN 0.357127454961099 0.226382067151821 0.624057928195541 0.61547502054461 0.0347599080880334 0.37720666979567 True False False False False False False 0 insufficient_or_context_specific +HIST1H4C 0.516962248457296 0.226576159245852 0.624339147707637 0.304920522257925 0.480761605521172 0.780346070738476 True False False False False False False 0 insufficient_or_context_specific +MRPL22 0.314115744467785 0.226675534353872 0.624377848084576 0.328821895429054 0.205235808122052 0.578666837313374 True False False False False False False 0 insufficient_or_context_specific +ZNF532 0.412014074233415 0.226897582785674 0.62466354082168 0.377252524827595 0.271004406199357 0.634989906935822 True False False False False False False 0 insufficient_or_context_specific +AIMP2 -0.36068875132724 0.22698396557916 0.624738453749941 -0.288529103947454 0.336201779521778 0.684718759551425 0.314124434184146 1.0 0.509321906994417 0.205545898991761 0.0366115209354561 0.924022101894769 0.545933427929873 0.144803922849201 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADGRG6 -0.638704218037599 0.227074760120838 0.624825467124266 -0.891259164749193 0.0879919047446492 0.468622105620855 -0.446276140635764 0.550012571025168 -0.159681530415761 0.803868933463943 -0.605957671051525 0.351893343703584 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PON3 -0.420469923724448 0.227264496389356 0.624853546501544 -0.57507888540982 0.0949728035451083 0.475178240428531 -0.185775966434228 0.666861275834619 0.735749541747179 0.0383543314302739 0.549973575312951 0.120633298837255 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTF2H2C 0.331318444553537 0.227275727740126 0.624853546501544 0.369747864556528 0.175786431413597 0.557945366367344 True False False False False False False 0 insufficient_or_context_specific +RNH1 -0.385942946465882 0.227454619982998 0.624853546501544 -0.445366409695201 0.158957796602667 0.543060696740211 0.15414881735379 1.0 -0.252316537374835 0.412466340475052 0.139539655127231 0.602534614197996 -0.112776882247604 0.703164081299825 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APH1A -0.354482062139133 0.227524695902797 0.624853546501544 -0.284845291807991 0.341553904488888 0.689048585850067 0.339494276663005 1.0 0.387877314258399 0.158351679534532 -0.0116121935349123 0.967064446935449 0.376265120723486 0.141727446607445 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATXN1 0.233575896395724 0.227558428329081 0.624853546501544 0.322030495546924 0.0840367696774411 0.464779732481256 0.9419375650642459 1.0 -0.0378619839220913 0.936257534403958 -0.192732009975916 0.547750736161489 -0.230593993898008 0.503776106508689 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LMAN2 -0.271689274164755 0.227776346065317 0.625126764168863 -0.104597893016618 0.649750177269424 0.869573123540446 -0.217206987924267 0.488335954733525 0.465124928966272 0.0828705795152564 0.247917941042006 0.363758498193259 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC020687.1 -0.605549559057062 0.227864543659303 0.625206302483088 -0.703402682912519 0.161372284505662 0.543541307772207 False False False False False False False 0 insufficient_or_context_specific +PDXDC1 -0.19377703690717 0.228140130803517 0.625799818400502 -0.0685370704288736 0.666016309130043 0.87511808324756 -0.181336470997687 0.705726107349112 0.178290405065153 0.630173852305263 -0.0030460659325335 0.995456814944428 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCRIB -0.411770607562833 0.22821477640856 0.625841976447162 -0.546723159322216 0.103392801673789 0.47952541118609 0.474238922487864 1.0 0.0768843131269691 0.813377867232966 -0.894687250150131 0.0040703474791481 -0.817802937023162 0.0092587363325423 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC139720.1 0.437217296223484 0.228300563682859 0.625914658884349 0.883460332694831 0.0154041707770188 0.320853404849916 0.0399889244217239 1.0 True False False False False False False 0 insufficient_or_context_specific +CELF1 -0.146491549607029 0.228514297209639 0.626337993234519 -0.211975084210687 0.0758869521346643 0.45450267784572 0.213437612206043 1.2260616487589 2.0 0.107111436436267 0.699585298631449 0.173587693011358 0.410633050716748 0.280699129447626 0.215013919939341 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DUT -0.27506479364241 0.228681066659642 0.626535943428939 -0.0495319617017422 0.833056493901748 0.94503174627857 0.8886358682003019 1.0 0.570357653856282 0.0399475307784664 -0.624337958320012 0.0166606814192818 -0.0539803044637294 0.853344802016123 reversed False False False False False False False 0 insufficient_or_context_specific +AC025178.1 -0.424779201887096 0.228764544603008 0.626535943428939 -0.522818812116083 0.128874966801262 0.51287670542319 False False False False False False False 0 insufficient_or_context_specific +CSGALNACT1 0.48807243322945 0.228901015963771 0.626584632238916 -0.0846771113404772 0.833966445732339 0.945759155106555 1.25813398921994 0.164624138948734 2.0 False False False False False False False 0 insufficient_or_context_specific +GBA2 -0.245239445497094 0.22910111126751 0.626726990116936 -0.214041776470429 0.296977533371034 0.654889895570548 0.15926961243837 0.714820944325319 -0.483704818957646 0.13870519845678 -0.324435206519276 0.37546847433484 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EXOG 0.21035547672026 0.229164288298377 0.626726990116936 0.260132780906705 0.135255553044537 0.521860900181769 -0.0634181364236161 0.937478986894678 -0.157204654912908 0.778847583482528 -0.220622791336524 0.727615857289486 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL513314.2 -0.340026871754725 0.229214291159104 0.626726990116936 -0.454204671984669 0.104353901739671 0.480701786460493 False False False False False False False 0 insufficient_or_context_specific +GRAMD4 -0.400701413972387 0.229249823435462 0.626726990116936 -0.383724339873527 0.250678799675015 0.617370367849033 0.246974828500976 0.544056365712869 -0.519374359178578 0.117032950560062 -0.272399530677602 0.448013956133944 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SHPRH 0.188779199307625 0.229356194036407 0.626787909889572 0.160806535496873 0.30666183441936 0.661696690217148 -0.0205986163837001 0.951317427671677 -0.016511494620219 0.949547299972159 -0.0371101110039191 0.895385725123861 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FKBP2 -0.348242155220022 0.229437238395901 0.626787909889572 -0.0109748586073495 0.971486041177042 0.992040338141303 0.264788107759787 0.293784555986519 2.0 -0.716378828877337 0.0167739154051855 0.549749793280544 0.0388595696806424 -0.166629035596793 0.529113615624298 reversed False False False False False False False 0 insufficient_or_context_specific +CSRNP1 -0.58797561259622 0.229612974127608 0.626929667945154 -1.00401609913972 0.0307092034311519 0.375031405408838 0.2572208267637 0.578363363792614 2.0 -0.336570440069352 0.488930579330711 0.217891183482009 0.583153420831485 -0.118679256587342 0.799661631189171 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ST3GAL4 -0.311845516293123 0.229791539083313 0.626950070459745 -0.153886723438476 0.57240378867125 0.827730374888659 0.319948792768004 1.84341471831598 2.0 -0.0986261505142288 0.820810819173171 0.146877231362551 0.652937186610457 0.0482510808483224 0.900097135611324 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC008083.2 -0.696473820987917 0.229800271327023 0.626950070459745 -0.269673371827803 0.655260192840774 0.871339568994744 False False False False False False False 0 insufficient_or_context_specific +CENPT -0.441057255989876 0.22980647591203 0.626950070459745 -0.503933222112506 0.167599651947112 0.547623080618609 1.09583093077403 0.0641495577533093 -1.60819409514234 0.0076195310780943 -0.512363164368313 0.404527131971372 reversed False False False False False False False 0 insufficient_or_context_specific +AF241726.2 0.366293351032554 0.229964324930727 0.626974093492763 0.286532234404178 0.349169738023091 0.694288655897113 0.0342799415020666 1.0 True False False False False False False 0 insufficient_or_context_specific +APOA1 0.634012409412584 0.230075481651048 0.626974093492763 1.6215019415087 0.003624034071435 0.243710520549117 0.180276491480769 1.0 -2.0261781330694 0.0058798900530394 1.34650000645042 0.029488875875005 -0.679678126618983 0.239294070774583 reversed True False False False False False False 0 cross_species_direction_conflict +BNIP1 0.366725081752649 0.230107766262931 0.626974093492763 0.228590471793638 0.468793283923194 0.77300007678605 -0.408893557106819 0.220314181957399 -0.286611605350945 0.327305688411331 -0.695505162457765 0.0390573639841184 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EIF3J-DT 0.270675173384808 0.230171584237351 0.626974093492763 0.236637817529355 0.293173231114165 0.651509781962399 True False False False False False False 0 insufficient_or_context_specific +DIXDC1 0.430364825877443 0.230358690276281 0.627321911771207 0.18668929536593 0.606421303238591 0.846931578987574 0.409258951826228 0.0484305316171819 2.0 -0.779243558513166 0.159342691534864 0.378719208099186 0.420237573328528 -0.40052435041398 0.421380628945712 partial_or_other True False False False False False False 0 cross_species_direction_conflict +JADE3 0.273148082473497 0.230525807368649 0.627434968079753 0.224480023176819 0.326912988852157 0.676489102054191 0.0125563328690275 1.0 -0.709798636431907 0.320349903765884 0.247100498230047 0.689154905629435 -0.46269813820186 0.469546742012676 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C2ORF49 -0.235222037762714 0.230578487985361 0.627434968079753 -0.411200678898353 0.0252983443724695 0.351006805738558 False False False False False False False 0 insufficient_or_context_specific +FAM117B 0.362323749979456 0.230797399274814 0.627631740266304 0.300727823722677 0.321102564929597 0.672472248121257 -0.245238040819963 0.445370591747454 0.238088373726065 0.357140735926483 -0.0071496670938981 0.98462892688391 partial_or_other True False False False False False False 0 cross_species_direction_conflict +INMT-MINDY4 -0.35434849291151 0.230822019886471 0.627631740266304 -0.53487249268691 0.0545022699231507 0.419107768280135 False False False False False False False 0 insufficient_or_context_specific +ZNF169 0.292528046926571 0.230829138800347 0.627631740266304 0.25561160887296 0.297950378084624 0.655992445264821 True False False False False False False 0 insufficient_or_context_specific +FAM172A 0.193245909791352 0.231093722750541 0.628189373017562 0.234897053928064 0.137827692075292 0.523810858054217 0.4243377862522411 1.0 -0.263687254250044 0.522811530896292 -0.291529146212669 0.387078101090728 -0.555216400462712 0.12763402892501 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF45 0.537971375964898 0.231355131158316 0.628738088743758 0.379666248793625 0.38783772180428 0.721421893377307 True False False False False False False 0 insufficient_or_context_specific +SLC26A11 -0.347726949442955 0.231515805536076 0.629012834495598 -0.286337207475888 0.328558265316769 0.677523079143447 0.377615513001155 0.356460533039957 -0.790122420000642 0.0352045044015181 -0.412506906999487 0.280607001482396 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF555 0.540615848645352 0.231658673099162 0.629051285523724 0.512888266995557 0.25736835330453 0.621906676979798 0.3374012725916889 0.475720198151929 2.0 True False False False False False False 0 insufficient_or_context_specific +GCN1 -0.256823685573194 0.231729966849873 0.629051285523724 -0.178638873029755 0.405203620932075 0.733444811508554 0.295005416676091 1.0 -0.478134913965678 0.0794962642487819 -0.162820568885171 0.501498093809334 -0.640955482850849 0.0238621642159009 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CSNK1G2 -0.295345534585902 0.231749642079663 0.629051285523724 -0.437161017983872 0.0662903953184509 0.436071024157137 0.251505297588284 1.0 -0.0142856352328212 0.961509654240006 -0.0229244264688314 0.922793669732867 -0.0372100617016526 0.881567031086083 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IGFBP4 -0.359859161814537 0.231821533446935 0.629051285523724 -0.211934029979412 0.493722790320567 0.786363265568912 -0.714885455441668 0.132391367691087 0.337329851922428 0.423118529826509 -0.37755560351924 0.388982051404208 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNDP2 -0.319735892044605 0.23182786057708 0.629051285523724 -0.359647351191146 0.175817790670975 0.557945366367344 0.151984331039856 0.741363963772251 -0.315263716688183 0.355113076188798 -0.163279385648327 0.683169836203475 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CUL3 -0.158858141422862 0.23198368147791 0.62916240349039 -0.068736494044815 0.611638784417451 0.849024754914469 -0.0746394968640508 0.805647983937196 0.126575147853566 0.571266719743327 0.0519356509895149 0.843188603495081 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VPS13C 0.175895725683675 0.23198799363403 0.62916240349039 0.223789484685655 0.122456188848137 0.5038394341269 -0.0950265428027944 0.760341768020019 0.347872933406677 0.130587353028723 0.252846390603883 0.299605128383654 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SPNS2 -0.724582603002322 0.232129034516951 0.629293869977702 -0.684455283145534 0.261264833472477 0.624064807531042 -0.0564998578403275 0.919058541659912 -0.364074438085874 0.324154352000581 -0.420574295926201 0.296547419537758 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANGPTL4 -0.561540982290675 0.232155675654778 0.629293869977702 -0.479541953149898 0.30919761909858 0.662844357856409 1.25902154919558 0.618466561074816 2.0 -0.182606851149686 0.827859450888599 0.0687590333848306 0.92196790965069 -0.113847817764855 0.876324893409141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +H6PD -0.364249745392875 0.232495842287604 0.629892507793821 -0.53214971880251 0.0806683730469908 0.460700922547448 0.926855595929501 1.0 -0.142935004413278 0.725385890990066 0.284531428570682 0.365991737449 0.141596424157404 0.688032107326709 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NBPF26 0.582512642739809 0.232712314201658 0.630317243032609 0.627314536903915 0.199922453063574 0.575301515248082 0.0448401964339885 1.0 True False False False False False False 0 insufficient_or_context_specific +PRKCA -0.27403238180441 0.233034829672858 0.631028912974104 -0.138980831378668 0.53902034863294 0.812532387331037 0.581234101131457 1.0 0.483188707293603 0.496921024026562 0.2164277399873 0.679963165202719 0.699616447280903 0.249616224451841 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNAPC4 -0.339146373147282 0.233304484526056 0.631500587683571 -0.249206928123368 0.388467018887118 0.72189097377384 -0.13910640829392 0.599074224057728 -0.834668456739753 0.0037657511711964 -0.973774865033673 0.0033388329410027 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIP4K2C -0.404419819137203 0.233328641082934 0.631500587683571 -0.146519208563715 0.668557127405233 0.875941737812246 -0.001359128688626 0.99699280592687 -0.0826975977785814 0.76357958555958 -0.0840567264672074 0.785587231532416 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHI3L1 0.890898053369674 0.233458651294249 0.631690528027851 0.859822900997007 0.250787800825248 0.617494776378958 True False False False False False False 0 insufficient_or_context_specific +NFIX -0.242636821518864 0.233656374585632 0.632063541602639 -0.0760843769595944 0.721408745581428 0.90084370619145 0.427053886157196 0.267181808660539 0.0960942618209623 3.0 -0.344657078053329 0.175551123930146 0.3690279674528 0.105886370427742 0.0243708893994707 0.92923636652208 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCF7 -0.404500831862833 0.233772461961958 0.632215587447324 -0.434129210710781 0.201266742179398 0.576216193866676 0.074647322766313 0.940338218920355 0.207668841728839 0.732217314347167 0.282316164495152 0.704157063557181 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKZF1 -0.293363103025377 0.234200669478849 0.633211438759972 -0.285422675682646 0.248315462382814 0.614136532744356 -0.223202927436327 0.5826910238579 -0.808102911006083 0.0278575143529714 -1.03130583844241 0.0154950776241598 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPATA18 0.495781796207739 0.234321259967816 0.633274624694561 0.491095589750852 0.239981330659167 0.606794054569195 True False False False False False False 0 insufficient_or_context_specific +ABCB4 -0.603671196933287 0.234430918234563 0.633274624694561 -0.574213801020135 0.259854889930156 0.622885940784012 0.0297607981031872 0.960402980964484 0.562843391292056 0.157865125664336 0.592604189395243 0.164871112322342 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HNRNPAB -0.399238850311385 0.234445683641613 0.633274624694561 -0.341020155245167 0.313911852050123 0.666609811562304 0.5314095634056 0.309515330803795 2.0 -0.0026778160438053 0.994302327353405 -0.472478050178365 0.0624461886446697 -0.47515586622217 0.0767117584130184 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZCCHC7 0.238505118615571 0.234510445338522 0.633274624694561 0.289092659918388 0.144835299399165 0.532658823056677 0.284204291809758 0.146659946642072 0.0856314534381761 3.0 -0.190499089110815 0.560983902319736 0.16694107703487 0.530564148083358 -0.0235580120759454 0.942248013482911 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CHD6 0.210349500813782 0.234530316796704 0.633274624694561 0.142711498967007 0.420805596247658 0.742471251256147 -0.481534645973267 0.164600929818211 0.141560294468475 0.656367712205855 -0.339974351504793 0.286319702684933 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RNF185 -0.214339940356603 0.234820925096052 0.633590423502202 -0.301055826617502 0.0962317831963043 0.476108325673187 0.777856052659139 1.0 -0.319052250675499 0.386576293829795 0.178942618367468 0.565946266764359 -0.14010963230803 0.691791576134424 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OTUD5 0.259015507202493 0.235098408590415 0.633752316308997 0.183648053630726 0.403869031618296 0.732402823054958 -0.20858588376571 0.585296144312293 -0.352171952744524 0.250709580059907 -0.560757836510234 0.0948428153008631 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MKNK2 -0.379240108925434 0.235314678528597 0.633752316308997 -0.24465808280088 0.457332759441196 0.76776776876263 0.8741849397776641 1.0 -0.300445691952764 0.270026448052221 0.398367688747287 0.0994777193711543 0.0979219967945233 0.715577187377836 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RLIM 0.288832598106783 0.235368531010193 0.633752316308997 -0.0289309470628158 0.899798402435254 0.968057977213875 0.0680863034638483 0.825156336653396 -0.0395577472659791 0.874194969831856 0.0285285561978692 0.917335477477782 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MT-ND4L -0.384681086476212 0.235373706813048 0.633752316308997 -0.139210548296141 0.667476696819795 0.875419277100913 -0.815094683918258 0.106917161365729 0.854890094712133 0.0665139814003498 0.0397954107938752 0.941142242357347 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLE1 -0.254051748449292 0.235392263128768 0.633752316308997 -0.398100683603058 0.0476164687009657 0.401835832584717 -0.176535396640655 0.558969167050118 0.162532903860279 0.504204575221139 -0.0140024927803756 0.963606419914876 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LUC7L -0.204540424260574 0.235414760834704 0.633752316308997 -0.303833768065442 0.0678324653584365 0.43786261079484 -0.187520180293961 0.625329340374314 -0.334538903164637 0.275082590491085 -0.522059083458598 0.113224774154958 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL356599.1 0.345648867083155 0.23541497834162 0.633752316308997 0.380086933297702 0.192005137899609 0.570885363891703 True False False False False False False 0 insufficient_or_context_specific +ADH6 -0.755066763688697 0.235512854700703 0.633837552875357 -0.857014584464876 0.174734908992675 0.556852148851393 False False False False False False False 0 insufficient_or_context_specific +CTXND1 -0.747985991352452 0.235685754402299 0.633979667510694 -0.914090358039079 0.145796240031125 0.532658823056677 False False False False False False False 0 insufficient_or_context_specific +PLEKHJ1 0.478718664571957 0.235897959592844 0.63418895557405 0.583878135507654 0.150340838046182 0.533583468169136 0.316869820343891 1.0 -0.0460491723840046 0.869015643979454 -0.34902767846998 0.0842105533820004 -0.395076850853984 0.0676701997856136 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TP53I11 0.51957331295834 0.235947022796189 0.63418895557405 0.433440236500382 0.31808733725668 0.670065065194738 1.37377958734398 0.0206442432049626 2.0 True False False False False False False 0 insufficient_or_context_specific +PRDM5 -0.396058290409927 0.235979693286156 0.63418895557405 0.142282565605767 0.678480837182372 0.880157669422479 0.490636107790582 0.346171337552852 -0.7349723841342 0.101235791008107 -0.244336276343618 0.633737766435946 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF280D 0.246158202616585 0.236007937096842 0.63418895557405 0.24520474536047 0.237677277407074 0.605329180588419 0.209583048847416 0.0889319731789563 2.0 True False False False False False False 0 insufficient_or_context_specific +ADGRL4 0.697994760548831 0.236173623985468 0.634322340889996 -0.446479258448377 0.402320470822071 0.731353225024006 0.322935791282077 0.46104734065596 0.316108411843557 0.367238708486006 0.639044203125634 0.10147123552864 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC093152.1 0.321293340747815 0.236442243974738 0.634711196312224 0.278813427695906 0.306254026415685 0.661696690217148 True False False False False False False 0 insufficient_or_context_specific +AC107204.1 0.553057063293409 0.236468484511099 0.634711196312224 0.204418474416849 0.658831456800083 0.871710320505013 True False False False False False False 0 insufficient_or_context_specific +GLIS3 0.246344643053343 0.236619631396514 0.634711196312224 0.155275209434453 0.459510168036978 0.768508526235589 3.47408339060985 1.0 -0.277628927826895 0.411214661307159 0.640795885461848 0.032144837949862 0.363166957634953 0.217334618499353 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GOT1 0.618743429212882 0.236748366776685 0.634711196312224 0.495708701427264 0.346974851931105 0.691856064986949 0.493684601397157 1.0 -1.33111528956738 0.0294847817509291 1.00269931357664 0.0631027379832014 -0.328415975990741 0.549826368576849 reversed True False False False False False False 0 cross_species_direction_conflict +DYNC1LI2 -0.181795873198305 0.236790526454063 0.634711196312224 -0.15935469746265 0.298981700968128 0.657023958480272 0.26363619033062 0.292954115194003 -0.528849532509538 0.0273407528137498 -0.265213342178917 0.24887252230573 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL7L1 0.262608958058001 0.236844684087034 0.634711196312224 0.0581948584206589 0.78295463281656 0.924823872729453 0.381792687442786 1.0 True False False False False False False 0 insufficient_or_context_specific +HGF -0.414546095520716 0.236864119845458 0.634711196312224 -0.354614391205478 0.315433061726583 0.6678047454801 0.223991854159851 0.587662004240426 -0.0439353742536056 0.910600467562093 0.180056479906245 0.625804260474455 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZBTB21 0.404459138850817 0.236919570436302 0.634711196312224 0.12903239026315 0.709033707732429 0.894061613070463 -0.284451526542902 0.307415812157617 -0.212268894260373 0.377193552912849 -0.496720420803275 0.0634667610572241 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ATG4D -0.380750270171981 0.237137671814694 0.634812256343697 -0.211513875624183 0.522015404711677 0.802364047597304 -0.290395184573293 0.219932855846463 -0.16043381369129 0.440757362283394 -0.450828998264583 0.0520900391262909 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HMGB2 0.355128175249341 0.237282189630774 0.634877181480413 -0.0193680158538112 0.948489192462221 0.986642915209573 False False False False False False False 0 insufficient_or_context_specific +LINC00598 0.949907594695151 0.237634344962298 0.635230791037838 0.47783277015648 0.549491827535807 0.816427626670848 0.5716442570857421 0.5444102682880421 2.0 True False False False False False False 0 insufficient_or_context_specific +TTC31 -0.382900298717214 0.237636615136066 0.635230791037838 -0.467023570319458 0.149393333868303 0.533583468169136 False False False False False False False 0 insufficient_or_context_specific +EWSR1 -0.213790471162086 0.237727287571335 0.635230791037838 -0.200480158746336 0.269322000976555 0.633720010321031 0.6101183396936489 0.00592974367455723 2.0 0.232483723735794 0.571861546955933 -0.104011241029278 0.756829815125914 0.128472482706517 0.737568491771436 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLOD3 -0.255128323935289 0.237814350279014 0.635230791037838 -0.150963922941378 0.49337943450757 0.786363265568912 0.196429501916301 0.499904099090131 -0.299876183879167 0.208412098879618 -0.103446681962866 0.707280372614399 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM241 0.311540338645639 0.237828166137816 0.635230791037838 0.495961454965566 0.0527933562020049 0.416275022241051 0.350616123275468 1.0 -0.317407730031617 0.460133475659553 -0.305488572484947 0.396188268577813 -0.622896302516565 0.109569125016934 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ERBB3 -0.758687653084694 0.237895676052625 0.635230791037838 -1.20282375646583 0.0560497934451761 0.423176389306643 -1.20205381064585 0.0244215242789217 0.867632392229005 0.0618162405462568 -0.334421418416844 0.466432269754061 reversed False False False False False False False 0 insufficient_or_context_specific +BCO2 -0.599458773440215 0.237989681259292 0.635321126355399 -0.997261043632366 0.0382845257487497 0.379484931484566 -0.892740337099348 0.0636226328770745 0.55862384095626 0.168252501936094 -0.334116496143088 0.429099505361364 reversed False False False False False False False 0 insufficient_or_context_specific +AGAP6 -0.211199120867907 0.238058302982919 0.635343671105576 -0.162716110745056 0.372341835250205 0.711011954525532 False False False False False False False 0 insufficient_or_context_specific +BRIP1 -0.607373172964311 0.238155213533442 0.63543424090347 -0.577118317660856 0.26599315262522 0.628408079081913 1.05021635227637 1.0 0.649599960376296 0.311306748879438 -1.20978943858862 0.0349929751368232 -0.56018947821232 0.396276709846248 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00702 0.839607581675388 0.238366522597912 0.635523673128474 1.56265215290697 0.0361558202153077 0.37720666979567 0.8922647104622451 1.35148240427255 0.0412998815966573 3.0 True False False False False False False 0 insufficient_or_context_specific +IPO7 -0.271326458851657 0.238888954056029 0.636595047179091 -0.053347687260128 0.817075428111754 0.936371599889798 0.332200710118336 0.0790665330001785 2.0 0.134334984669525 0.801922716373263 0.345942768231277 0.323100105546641 0.480277752900802 0.23061635174664 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A33 -0.439804943367242 0.239446388459845 0.637758569464944 -0.596636599368933 0.107710265523328 0.483917014210766 -0.666937233854459 0.144193447691094 0.718613684135341 0.0760255557811435 0.0516764502808818 0.915623944186084 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCGF6 -0.277095707973839 0.23954659374527 0.637864548994342 -0.286306022852522 0.223660090302025 0.594811897584077 -0.200063946917066 0.691977818166691 -0.488514087169159 0.208412098879618 -0.688578034086225 0.11496566512186 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAMSAP1 -0.289055005243014 0.23964907958995 0.637976546220549 -0.135487705327436 0.587232519944289 0.835274227991216 0.362766705038062 1.0 -0.0578879880436148 0.919292223397175 -0.30583643329315 0.413741101053848 -0.363724421336765 0.382954015332693 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAMK1D -0.265657885336286 0.240068539946019 0.638634068317566 -0.341790097296031 0.124251766769162 0.506294648147501 0.609935062468244 1.0 -0.480062018853089 0.0928837610594443 0.121200226155649 0.641076384764568 -0.35886179269744 0.172516762636239 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COLEC10 -0.651710756808362 0.240129737869508 0.638634068317566 -0.491898805512951 0.375863303480328 0.7132826228158 0.523165323069608 1.0 -0.616771765834686 0.103604340334477 0.202810339315769 0.551852971618274 -0.413961426518917 0.233677887854942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP4F12 -0.776812680938843 0.240144234288695 0.638634068317566 -0.827714805220425 0.20905174077317 0.58144580587016 1.18385680006547 1.0 False False False False False False False 0 insufficient_or_context_specific +DNPEP 0.216887333899637 0.240198511582596 0.638634068317566 0.129018852505427 0.481527101860748 0.780620676622582 -0.0267485263668322 0.950633272242692 -0.10703322953079 0.725594259838567 -0.133781755897623 0.688030642577983 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SUOX -0.581789959713911 0.240410002933198 0.639035450898465 -0.727830771493924 0.137429521207805 0.523810858054217 -0.627338688895026 0.239105460690219 1.24185786198386 0.0180023058783866 0.614519173088835 0.200325451214065 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLCG1 -0.259643778837332 0.240793659529196 0.639881966907748 -0.381081444215272 0.0747500196181079 0.452862231765951 -0.0736554465814542 0.836933962693437 -0.448489799144171 0.0869891105609726 -0.522145245725626 0.063293104984058 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SUMF2 0.228484975548975 0.241213598420756 0.640162035467699 0.222066011715207 0.255914988978561 0.620670263344767 0.393505530938408 1.0 -0.297544906710969 0.325017572953707 -0.0352478471765272 0.906123521623629 -0.332792753887496 0.226041628690408 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AOX1 -0.589596772690146 0.241258262845802 0.640162035467699 -0.789563276938891 0.11311481834789 0.4924007041452 -0.262740775898811 0.47536338372137 0.303257548758618 0.320881844028219 0.0405167728598066 0.915396363897615 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTC39B 0.287527955525396 0.241447549520694 0.640342433519087 0.202478726501697 0.419017843696654 0.740788746441606 1.63138308577819 1.0 -0.445223746801858 0.123436358595176 -0.386479823023045 0.134722493720024 -0.831703569824903 0.011142220546085 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SHC1 -0.384433350497455 0.241619579446445 0.64036258261901 -0.417791430344204 0.202365976669276 0.57668584531318 0.450516336200635 1.0 0.318843814847924 0.221290077159688 -0.438006551194135 0.0657719812495692 -0.119162736346211 0.642996249604373 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INTU 0.321455179341826 0.241629472925945 0.64036258261901 0.324329591669357 0.237696196658505 0.605329180588419 0.322641784103899 0.0468001977652968 2.0 -0.440908168237336 0.249113499665528 -0.741880420013877 0.0441192484299629 -1.18278858825121 0.0095170977344524 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SBF1 -0.420739392461908 0.241637102590845 0.64036258261901 -0.360967966392131 0.321392033217515 0.672472248121257 -0.0165265434344186 0.969651685100975 -0.788894047501128 0.0189376862160248 -0.805420590935547 0.0260063020234298 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MCM7 -0.360400649942963 0.24178094239199 0.640422275407584 -0.395052572773513 0.195631218238926 0.571527055075728 0.163017884844333 1.0 0.69814815613838 0.0488924381808764 -0.887955384175526 0.0106525003964253 -0.189807228037147 0.583965182395397 reversed False False False False False False False 0 insufficient_or_context_specific +SLC39A14 -0.499227398167756 0.241935673936211 0.64055798533231 -0.563339664009631 0.187136611765458 0.56929178900529 0.683968742344574 1.23765162395425 2.0 -1.24645355236238 0.006336398642225 0.64057929008268 0.0804972454670506 -0.605874262279698 0.105055826582113 reversed False False False False False False False 0 insufficient_or_context_specific +ZMIZ2 -0.354231955005786 0.241953518233117 0.64055798533231 -0.381011905753522 0.205987672321778 0.578776160707106 0.0370530100136684 1.0 -0.0413401751633657 0.895179480351654 -0.266910958050242 0.213335275599931 -0.308251133213608 0.179456041844568 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DYRK3 0.442117077273717 0.242170961203073 0.640972927646538 0.198310483519316 0.602441282400806 0.844697883079378 0.299578236841925 1.0 True False False False False False False 0 insufficient_or_context_specific +AC019117.1 0.830859318808476 0.242456684348003 0.641246912160877 1.0240158937102 0.177696161123111 0.560377630006132 True False False False False False False 0 insufficient_or_context_specific +AGAP5 -0.260813323556345 0.242574932994606 0.641398983861019 -0.0974203093078767 0.655361575808606 0.871339568994744 False False False False False False False 0 insufficient_or_context_specific +WDR59 -0.169965881416786 0.242647912967631 0.641431313247934 -0.256839318664953 0.0660190340294707 0.436071024157137 0.102744376693142 0.775329154105402 -0.34124794990237 0.195157978375258 -0.238503573209227 0.406626709410067 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GREB1 -0.761211211482806 0.242716312072987 0.641451520116794 -0.389011615979739 0.572538873103652 0.827730374888659 0.015924451480081 1.0 False False False False False False False 0 insufficient_or_context_specific +HNF1A -0.798901912656363 0.243328375753734 0.642104721621574 -0.993378399451021 0.140792178905495 0.526401063874107 -0.620098288740662 0.192710521342495 -0.410997276558782 0.334819040413064 -1.03109556529944 0.0350375726175054 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FOXP1 0.243306259317284 0.243682346653987 0.642250060235767 0.160018942493308 0.451700589315091 0.764215212079295 0.808369013907341 0.52782999665525 2.0 -0.0151020271996792 0.963257176400296 -0.0208494777160017 0.936425726070351 -0.0359515049156809 0.89706283302159 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GTF3C2 0.179810756591778 0.243688756903957 0.642250060235767 0.137277762411303 0.373521254194408 0.711968837980936 -0.307925853101787 0.375426970782584 -0.520704567828054 0.0909973588817321 -0.828630420929841 0.0214221652310329 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ALG5 0.242183294071616 0.24382641042575 0.642250060235767 0.334074390521661 0.106658567392463 0.483261130274234 -0.071377523776154 0.834981566938799 0.0693212857649943 0.785358527720079 -0.0020562380111596 0.995383082538173 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EXD3 -0.230174835933209 0.243904583818972 0.642250060235767 -0.244471465380413 0.214074577145734 0.587064775455755 False False False False False False False 0 insufficient_or_context_specific +FAM157C -0.309582879122339 0.244083394965018 0.642250060235767 -0.540503204887633 0.03411306448617 0.376543096535729 False False False False False False False 0 insufficient_or_context_specific +CRLF1 1.08799147199775 0.244112275673265 0.642250060235767 1.06704451896958 0.253425144695524 0.618991529980024 0.0918460885527829 1.0 True False False False False False False 0 insufficient_or_context_specific +ZCCHC14 -0.296975840858812 0.244599550129671 0.642250060235767 -0.0232930442958317 0.928176104736561 0.979087152943213 0.312215162598736 0.258840084741288 -0.286844692314317 0.231818483287446 0.0253704702844194 0.931807716855015 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UVSSA -0.329888145053909 0.244752463865278 0.642250060235767 -0.259693465006091 0.361041812650858 0.703177809506737 0.389871170199907 1.0 0.0570973936472918 0.895126810967348 -0.372261540785991 0.206633324845706 -0.315164147138699 0.319843724086639 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EDA -0.392098235174283 0.244757289912711 0.642250060235767 -0.465295023734118 0.168159279983568 0.547801813658289 0.3300420756469289 1.0 -0.320071570888793 0.603562155863719 0.483786743591369 0.283977037318444 0.163715172702576 0.768255846359741 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF708 0.184787714723971 0.244830058592487 0.642250060235767 0.0645273695668278 0.689995673806304 0.885210584988815 True False False False False False False 0 insufficient_or_context_specific +SEC61B -0.303980886151617 0.245013136184395 0.642250060235767 -0.209868693383384 0.427560854160914 0.747680419889399 False False False False False False False 0 insufficient_or_context_specific +KIAA1586 0.336773298841771 0.245059821285956 0.642250060235767 0.107373388260231 0.71552209347512 0.897313488883515 True False False False False False False 0 insufficient_or_context_specific +ZNF714 0.365603155051136 0.245076147614261 0.642250060235767 0.248782714921588 0.433130152903066 0.751350456611089 True False False False False False False 0 insufficient_or_context_specific +ZNF341 -0.361270288331097 0.245129498785154 0.642250060235767 -0.158940594156895 0.625261734336107 0.856338486330344 0.5401620275495159 1.0 False False False False False False False 0 insufficient_or_context_specific +ALDH2 -0.345408814851797 0.245265782691916 0.642250060235767 -0.413631598627953 0.161983318649524 0.543541307772207 1.11485902291973 0.326294042322524 2.0 -0.697010187409643 0.174631956574193 1.41906639866301 0.00988721813255 0.72205621125337 0.131027427451444 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BRD1 -0.183435128853875 0.245365101919985 0.642250060235767 -0.199518181473881 0.205439127177251 0.578666837313374 0.4490705070630029 0.0033848992927934 2.0 -0.288476723260543 0.26778031421187 -0.313385754138434 0.171404608640216 -0.601862477398976 0.0254654852501922 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WRN 0.180652017050886 0.245408404491563 0.642250060235767 0.181396369557218 0.242353115340871 0.608939598231536 0.102115301736441 1.0 -0.371182388837411 0.22024511177881 -0.175655680451373 0.510534817220074 -0.546838069288784 0.0637592023533788 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BACH1 0.255280675369996 0.245415331225664 0.642250060235767 0.504048329975727 0.0096772319003664 0.300429821921613 0.103455752163627 1.0 -0.501085950743197 0.0674209734718208 0.0803005775297859 0.75237983630296 -0.420785373213412 0.10017777987315 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RRAGB 0.196793339205413 0.245529941129243 0.642250060235767 0.2176949353306 0.196017728472172 0.571700325195908 0.062679997418394 1.0 True False False False False False False 0 insufficient_or_context_specific +RPL30 0.356283748523925 0.24553666038718 0.642250060235767 0.482911287445685 0.121586013435878 0.503485437181972 True False False False False False False 0 insufficient_or_context_specific +ADGRG2 0.452770028556273 0.245573356049611 0.642250060235767 0.731366800128163 0.0570360776667633 0.424455207563489 0.0125790463743943 1.0 True False False False False False False 0 insufficient_or_context_specific +EIF2AK3 0.349640753010298 0.246899705049655 0.645192517153539 0.435160253569684 0.146331785897838 0.532796338690088 -0.367998455295605 0.208749546136599 -0.712342921726462 0.0170123406083983 -1.08034137702207 0.0040675846606289 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLFN12L 0.525557023650571 0.246982280604633 0.645192517153539 0.375423271263209 0.409069043050937 0.734857324041122 0.8773678827604949 1.0 True False False False False False False 0 insufficient_or_context_specific +SLC6A1 -0.486321805258357 0.247162631785788 0.645192517153539 -0.490885262595403 0.24328913983529 0.609898739043611 0.0252422971328644 1.0 False False False False False False False 0 insufficient_or_context_specific +ERRFI1 -0.760447608785736 0.247343678649718 0.645192517153539 -1.00959809248635 0.121671915788388 0.503485437181972 0.5919877808391999 0.310993051818004 2.0 -1.20509832186137 0.0188475282122586 0.989619081263166 0.0332682484011331 -0.215479240598204 0.644387650688514 reversed False False False False False False False 0 insufficient_or_context_specific +SKIV2L -0.383498078316986 0.24735581566633 0.645192517153539 -0.0720267637722913 0.836566306694973 0.947349959049485 0.0120029254898496 1.0 -0.410454844443808 0.0837767198695085 -0.634865103442206 0.0109043613003895 -1.04531994788601 0.002310693597717 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ING3 -0.237222244075783 0.247389240295602 0.645192517153539 -0.23392068831723 0.253708686646561 0.618991529980024 1.39932844513903 1.0 0.351993049322618 0.437516317519058 -0.0589618387498572 0.882622588192181 0.29303121057276 0.472621933640747 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE3D 0.269731764293785 0.247404811182376 0.645192517153539 0.269327261874149 0.248539082237912 0.614215233681543 True False False False False False False 0 insufficient_or_context_specific +C6 -0.503126942849039 0.247583111012124 0.645427774337285 -0.637234105187357 0.141337065553383 0.526923646040233 0.293724249563619 1.0 -1.24971275503443 0.0091946892558076 1.35844096269781 0.0052957799191449 0.10872820766338 0.802978348889929 reversed False False False False False False False 0 insufficient_or_context_specific +ZIC1 -0.936259261504744 0.247687080620484 0.645539421671455 -1.05202320007364 0.189591536601824 0.569886897607216 False False False False False False False 0 insufficient_or_context_specific +DCAF12 0.282237698779697 0.247872001282398 0.645830652836786 -0.0362802436587783 0.88294311266323 0.962778177759102 0.333013793582335 0.215523422767541 -0.250506513796155 0.276707199013225 0.0825072797861799 0.764955024086208 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RRNAD1 -0.323258334494892 0.247942509724313 0.645830652836786 -0.199944864233056 0.48387577968768 0.780666906162311 0.627970276931797 1.0 False False False False False False False 0 insufficient_or_context_specific +NEMF 0.144123265058476 0.247982332506188 0.645830652836786 0.0622283433541978 0.612929066561302 0.850256876199477 -0.0447594653813538 0.886337907728528 -0.429169500221142 0.0600757878989589 -0.473928965602496 0.0526568418028421 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SENP2 0.201423103662454 0.248359903997893 0.646387089570654 -0.0655766078864452 0.708369713205416 0.893638108503159 0.0520590357033475 1.0 -0.158121458504703 0.56724880758769 0.0921327561677904 0.689565874743376 -0.0659887023369122 0.800741159144445 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIMD1 -0.386996780466802 0.248417044509918 0.646387089570654 -0.466645420088626 0.161041892654729 0.543541307772207 0.693227559765807 1.0 0.212087869264756 0.407328235360787 -0.0645793835836779 0.78043078980711 0.147508485681078 0.532242534791447 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC010737.1 0.994758674505264 0.248467523135271 0.646387089570654 -0.0277979512756054 0.974533803132761 0.992488462764126 False False False False False False False 0 insufficient_or_context_specific +ARFGEF1 0.180175280309678 0.248502102345831 0.646387089570654 0.282965871965561 0.0603023022204385 0.429268745755419 -0.108262126320423 0.743210363848798 0.03476133864616 0.904538829071086 -0.0735007876742629 0.801846654427446 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL136295.1 0.406108848155538 0.24875094355071 0.646874990642463 0.52723721959491 0.138382104894114 0.523810858054217 True False False False False False False 0 insufficient_or_context_specific +TNFAIP1 -0.367320203537772 0.249081407784084 0.647217814295563 -0.213300910597406 0.504667935937192 0.792781441396351 -0.151523993356027 0.667345616128091 0.489916158236727 0.072917402172368 0.3383921648807 0.233702026616879 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UQCRC1 0.311400876906142 0.249198076237171 0.647217814295563 0.171865536118737 0.525276638239102 0.804676662787375 -0.158939351134102 0.688936764998849 0.700978371536538 0.0376063844170889 0.542039020402435 0.102370356417083 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL359710.1 0.293999170968945 0.249230135123533 0.647217814295563 -0.0584812479091757 0.816595846059772 0.936230700610385 False False False False False False False 0 insufficient_or_context_specific +AL139260.1 0.1860933542768 0.249531400248687 0.647787687195879 0.235426245458117 0.139632616111144 0.525014658440692 0.0775605474789419 1.0 True False False False False False False 0 insufficient_or_context_specific +MT-CYB -0.32065307412379 0.249691388371895 0.648043677096967 -0.216038671950329 0.440215908023415 0.756769095948255 False False False False False False False 0 insufficient_or_context_specific +BDP1 -0.136950958958365 0.249786763332958 0.648082636184426 -0.111710894474622 0.349140382253774 0.694288655897113 -0.0504154969522458 0.914881531455775 -0.207184674045171 0.508807794493669 -0.257600170997417 0.448716521868339 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LARP1B -0.180787911799939 0.250067681271703 0.648382755124421 -0.138276939935789 0.390035387632377 0.722218665388488 -0.489205114838289 0.103344360140156 0.368860098711194 0.163637185005837 -0.120345016127095 0.684448066895664 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TET3 -0.192397109518947 0.250240222044403 0.648511601459206 -0.0960111360423985 0.575827926223515 0.829928048970172 -0.188096749960896 0.5806539569772 -0.125769473827072 0.658688820308847 -0.313866223787968 0.278268778131434 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTC27 0.235154415786041 0.250603104107919 0.649251379273091 0.277831745845279 0.170651851801008 0.550991514163622 -0.003908141731371 0.993658320585987 -0.137986798575135 0.654856960683749 -0.141894940306506 0.687812477277199 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LITAF -0.357937853563434 0.250728322593567 0.649251379273091 -0.606519916227997 0.043966636645213 0.393650849907072 0.103445018429374 0.706776681862378 0.113427849212415 0.598580409001527 0.216872867641789 0.332670203724069 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C20ORF194 0.18834729332547 0.250814101818615 0.649251379273091 0.304387642537922 0.0597675727345348 0.428473540531152 True False False False False False False 0 insufficient_or_context_specific +ARHGAP18 0.420900589298514 0.250818391693156 0.649251379273091 0.630574883861379 0.0768965521341487 0.455668688469891 0.7154178490145101 1.0 -0.455648515128577 0.189794555669877 -0.428651818431 0.167107147567351 -0.884300333559578 0.0192797801662944 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PDE7B -0.321533713082104 0.25083314794989 0.649251379273091 -0.157284019502567 0.577742244502657 0.83075298180061 -0.549444888924106 0.297263695934094 0.566049475537245 0.196130965826194 0.0166045866131384 0.976910451551985 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM168B -0.141749316239453 0.25090798086598 0.649285897544858 -0.18634890429065 0.125722789036009 0.507996233320616 0.82273372685192 1.25875574170459 2.0 0.218093438524145 0.472779016849149 0.21306168040955 0.383912031028419 0.431155118933695 0.109383866510683 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TELO2 -0.419150861281161 0.251116896368809 0.649412941929359 -0.59070228598502 0.09974274336587 0.478125555523304 0.92014803030237 1.0 0.258787040100612 0.520316567244718 -0.971454807657493 0.0123395386190866 -0.712667767556881 0.0594430145391538 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC013394.1 0.226680217864707 0.251121668790324 0.649412941929359 0.104440407210045 0.597679993995891 0.842278397346603 0.0229133487956801 1.0 True False False False False False False 0 insufficient_or_context_specific +ADAMTSL1 -0.560303758393977 0.251672074024886 0.650427292942485 -0.541398984808473 0.268771613224773 0.632971449177233 0.466600934260579 1.0 0.244204186896693 0.583620487806782 -0.836090693124957 0.0337170069446658 -0.591886506228264 0.127541175466943 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAD1L1 -0.19498690103585 0.251728367676934 0.650427292942485 -0.199739233395732 0.239250491528731 0.606713331305531 1.27168718659909 1.0 -0.443649729158279 0.188107042079834 -0.115483951519865 0.707860106483928 -0.559133680678144 0.0837070033475816 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TNN -0.515907095718036 0.251752195274959 0.650427292942485 -0.508301810498685 0.259667491580168 0.622885940784012 1.04776494540221 1.0 False False False False False False False 0 insufficient_or_context_specific +MMP19 -0.837626571697472 0.251834760790238 0.650427292942485 -1.28260587958847 0.0745550264172477 0.452862231765951 0.210123933939778 1.0 0.102448247589445 0.840958580277727 0.41690233938941 0.229466096723946 0.519350586978855 0.168467507999703 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STT3A -0.321495466750829 0.25184189937004 0.650427292942485 -0.0952087251916075 0.737483063873625 0.906654190542353 False False False False False False False 0 insufficient_or_context_specific +AC104986.2 0.222497377667054 0.252070228469876 0.650857782388103 0.342976265814512 0.0842814164056956 0.464779732481256 True False False False False False False 0 insufficient_or_context_specific +SLC4A1AP -0.235573430213143 0.252563390717767 0.651520820478842 -0.120627724087251 0.573275553002065 0.828221577530898 0.0335036451175559 0.930095922530229 0.339106414860842 0.159583465631992 0.372610059978398 0.159044166203214 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL023755.1 -0.90023002619814 0.252573850939562 0.651520820478842 -1.11100931786284 0.15060416131313 0.533583468169136 False False False False False False False 0 insufficient_or_context_specific +RNF43 -0.826905057186386 0.25291632017434 0.65212460222666 -0.778754946587229 0.286225145054016 0.64687121300967 -0.443015152302309 0.309283509391854 0.0762619178324532 0.855068913981196 -0.366753234469856 0.353594734463862 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNW1 -0.172536845680474 0.252931449717576 0.65212460222666 -0.0977101231630618 0.526866004033339 0.804819865166353 -0.288648478059233 0.265128245341405 0.219872165058267 0.322084284060207 -0.0687763130009663 0.792871789850276 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00623 0.200498978966153 0.253134053501515 0.652487631071531 0.266128271796656 0.123466123827233 0.505248083014988 True False False False False False False 0 insufficient_or_context_specific +RPL14 0.420791780480622 0.253407837068821 0.653033913539812 0.625796485207168 0.0883609689004508 0.468801562638673 0.0305697325956617 1.0 True False False False False False False 0 insufficient_or_context_specific +CLSTN3 -0.31511632971731 0.253528070092091 0.653037002638483 -0.193656994084006 0.485568178880581 0.782071323676502 -0.722033720657164 0.159126567854185 0.57659674560258 0.188778959523872 -0.145436975054584 0.774907957211345 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GCC2-AS1 0.341552854435441 0.253598906083397 0.653037002638483 0.117357043100451 0.694990177858161 0.887804754727944 0.0270144572023798 1.0 True False False False False False False 0 insufficient_or_context_specific +YY1 -0.143829429617081 0.253599828854405 0.653037002638483 0.0215711737381441 0.876244724494422 0.960584757679587 0.295488485383026 1.0 -0.380212101043436 0.21440359893014 -0.4267241044041 0.121278311096508 -0.806936205447537 0.0159316931008995 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATXN2 -0.156365160529175 0.253656445143059 0.653037002638483 -0.0777483346518453 0.571425868457882 0.82702046870162 -0.0475676273502189 0.912572716221127 0.16583927639779 0.573840778766638 0.118271649047571 0.721656160041071 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CRTC1 -0.318442822941453 0.25407947183512 0.653647919989082 -0.28831655451913 0.305088428467372 0.661381253594365 1.29910626528629 0.1372032871129 2.0 0.0663247151349126 0.901577906130256 -0.825761839555273 0.0356907663133761 -0.759437124420361 0.0722401954339136 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC027682.4 -0.374148008737259 0.254175204308301 0.653718704617906 -0.833364428195945 0.0057291224938091 0.265907216454356 False False False False False False False 0 insufficient_or_context_specific +TUBGCP5 -0.260827648370148 0.25423082034108 0.653718704617906 -0.31209750541456 0.164855456143781 0.545094551255265 -0.213966520404113 0.555793991388722 -0.425494981323776 0.150826116251216 -0.639461501727889 0.0562269353681508 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MSL3 -0.457681915764916 0.25430579765601 0.653752279438069 -0.303731075686958 0.463399846052589 0.769320698854699 -0.0025848685164131 0.995740876664603 0.105998471644368 0.718150415195762 0.103413603127955 0.756138553093988 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF145 -0.262614054631438 0.254494556749346 0.654078269269618 -0.246191567121304 0.285606586282328 0.646672600894021 0.225366837784442 0.396358355690065 -0.0593393709074788 0.804609681254125 0.166027466876964 0.494584831467942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A39 -0.341922392173924 0.254638052142334 0.654225053757106 -0.250650456455831 0.407452657520846 0.734170441890517 0.6997760415919749 1.0 0.180597048218719 0.685678336076267 0.0550706058815937 0.892624137814316 0.235667654100313 0.532833517610397 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC73 -0.6896363835564 0.255081201008659 0.654871771711577 -0.510804291557736 0.41399316376867 0.736592487878263 False False False False False False False 0 insufficient_or_context_specific +C17ORF80 0.389418624296421 0.255171415654935 0.654871771711577 0.461225293520853 0.184065647458812 0.565716727964854 0.2972407021966469 1.0 True False False False False False False 0 insufficient_or_context_specific +DRG2 -0.326388843505572 0.255269139893307 0.654871771711577 -0.28995094269249 0.3148072269621 0.667014790741693 0.556920621417306 1.0 0.0309333241108495 0.930095922530229 0.151575995763903 0.505949136749098 0.182509319874752 0.460839663030999 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRCIN1 -0.890584718733422 0.255274519488417 0.654871771711577 -1.16532326635158 0.123117537769818 0.504414033284339 1.37671510418634 1.0 False False False False False False False 0 insufficient_or_context_specific +COG7 0.245772240375732 0.255299508653614 0.654871771711577 0.244555033885755 0.257616977978106 0.621906676979798 0.434201125112932 0.0498565271583712 2.0 -0.112796504180051 0.714119903865672 -0.0361359536596667 0.89415111255265 -0.148932457839717 0.567424013010779 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TLE2 -0.467758383140993 0.255479859983424 0.655016699338478 -0.744463798751903 0.0547191092938483 0.420068725637921 0.52777169131225 0.0528016015779188 2.0 -0.379659085291096 0.215786916956177 -0.387128167461873 0.156508447172908 -0.766787252752969 0.0201349712657595 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MLKL -0.358990477147433 0.255505637090529 0.655016699338478 -0.413985542140712 0.187784660776449 0.56929178900529 -0.256420210800889 0.629499404007157 -0.15200785094009 0.728598847765413 -0.408428061740979 0.364222735478041 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL162411.1 -0.808116157364688 0.255783296156947 0.655017758358997 -0.986328289460995 0.159113445152185 0.543060696740211 False False False False False False False 0 insufficient_or_context_specific +AC010618.3 -0.254691057001871 0.255886291879076 0.655017758358997 -0.023869497727112 0.918808019593273 0.975930957742715 False False False False False False False 0 insufficient_or_context_specific +ASMTL -0.29779768323893 0.255931253732863 0.655017758358997 -0.465275588023502 0.065444460348444 0.435533238803682 False False False False False False False 0 insufficient_or_context_specific +ADAMTS14 -0.667496263816138 0.25594228829934 0.655017758358997 -0.550466719682603 0.354757230558703 0.698200328680699 0.317586127205378 0.534128553453078 -0.445166546374729 0.285544499423019 -0.127580419169351 0.795393571267629 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HPS1 0.220277963493689 0.256015228145626 0.655017758358997 0.203754888345977 0.294061481663145 0.652324662738756 -0.0459742984267638 0.909811235096639 -1.21941944552784 0.0022762705637506 -1.26539374395461 0.0035440769053387 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KLF6 0.410424912669182 0.256038860461032 0.655017758358997 -0.0181242717907256 0.964057174442749 0.989935386867005 0.856229186141516 1.0 0.418976630461865 0.252396678334889 -0.234559756142045 0.454595900392715 0.184416874319819 0.601008939802172 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NIN -0.2686923789884 0.256141969906173 0.655092087932454 -0.0605937615213695 0.803566440225914 0.931474264201915 0.328116220901649 0.300161201299016 -0.422131354748372 0.11836793546369 -0.0940151338467229 0.770447383529409 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A48 -0.89223266389493 0.256324103182792 0.65527115772492 -0.831542372757868 0.29090491370104 0.650060056248883 -0.575483321060006 0.349050879242194 0.338919368008044 0.500085839365991 -0.236563953051963 0.683477893020012 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMBIM1 0.321224653446535 0.25645275322251 0.655441338301442 0.0478050199770596 0.86692872072387 0.958391272020028 0.448823550306078 0.5202502269636621 2.0 -0.136946578748781 0.617456268780439 0.443091022351006 0.0518335536710733 0.306144443602225 0.181327509351142 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BHMT -1.22514876739155 0.256596484923339 0.655649972851069 -1.43406162306828 0.184136086492736 0.565716727964854 0.455732987319803 1.0 -1.12643323393012 0.0301543036093047 0.99761386128116 0.0309686788073514 -0.128819372648961 0.788459032075034 reversed False False False False False False False 0 insufficient_or_context_specific +USP30 -0.214739856809008 0.25668751388239 0.655709448163363 -0.317860395713894 0.078467360408655 0.457322349441485 -0.0329817143344649 0.948229672317339 0.192932873048205 0.547750736161489 0.15995115871374 0.671205755845056 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PALMD -0.469964569777042 0.256743972220813 0.655709448163363 -0.501043670089852 0.226523047899251 0.598909102217928 0.486492067441284 1.0 -0.24136410513476 0.594093355400225 0.48403190176916 0.166620725395219 0.2426677966344 0.531645920314272 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPRN2 -0.264119642981008 0.25683236774724 0.655776575254016 -0.327923350893114 0.152782248789156 0.536261629892258 False False False False False False False 0 insufficient_or_context_specific +PYGL 0.299538687842333 0.257035419520924 0.655993524105164 0.364762414208514 0.164430901314836 0.544850245278 -0.602405802024293 0.288973346897997 0.866901833291334 0.089203118453314 0.26449603126704 0.625804260474455 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF654 0.199908209537555 0.257042189745668 0.655993524105164 0.264076411316644 0.1410016183404 0.526598898633868 True False False False False False False 0 insufficient_or_context_specific +COL13A1 -0.46505529385737 0.257105004892615 0.655993524105164 -0.489546139063775 0.229419455401897 0.600837332554409 0.276593079370492 0.511568858399858 -0.715743794244612 0.0484412757933499 -0.43915071487412 0.242934738373338 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIA3 -0.180149665531474 0.257168059487828 0.655993524105164 -0.0766618121672297 0.640668566850497 0.864640237429136 0.289785178385713 1.0 -0.560725789293261 0.0825452834283036 0.286318875690706 0.31319589434607 -0.274406913602554 0.355302173345378 reversed False False False False False False False 0 insufficient_or_context_specific +LRIG2 -0.18571320235479 0.257341235466605 0.655993524105164 0.0175559938328083 0.918346404908246 0.975930957742715 0.159944716947933 0.75873333857183 -0.369395882909311 0.325418755947503 -0.209451165961379 0.636973520357278 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF490 0.250870263387788 0.257435625881904 0.655993524105164 0.218068040081535 0.320756468060933 0.672472248121257 0.0240698178282585 1.0 True False False False False False False 0 insufficient_or_context_specific +TPCN2 -0.338192276907054 0.25749202461935 0.655993524105164 -0.661105403941287 0.0145516002306095 0.317541556275699 0.203269347240819 0.672015056722389 -0.801829589861253 0.0436206811863824 -0.598560242620435 0.146406527335482 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASB1 -0.392081892507524 0.257554633657657 0.655993524105164 -0.297345444525098 0.395251994418621 0.726274872614038 -0.256204051817718 0.556507409807848 -0.1372594359706 0.704784050604652 -0.393463487788318 0.2942240725071 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SAMD11 -0.458024311542037 0.257709497214781 0.655993524105164 -0.494086122233301 0.218761800487251 0.591166390976299 False False False False False False False 0 insufficient_or_context_specific +AL592295.4 0.262256722068219 0.257793629483819 0.655993524105164 0.574251755378188 0.0170264363387101 0.326204572615871 0.0462908172181459 1.0 True False False False False False False 0 insufficient_or_context_specific +ZDHHC15 0.502949177188381 0.257901744863452 0.655993524105164 0.896317766585197 0.0468881409376191 0.399450754777127 True False False False False False False 0 insufficient_or_context_specific +IMPA1 -0.346099209793747 0.257911452790352 0.655993524105164 -0.263612889415653 0.396087185593583 0.726915037383597 -0.381315816202564 0.175144956637759 0.0356181921706034 0.902561468941076 -0.345697624031961 0.184130254292276 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OGDHL -0.65519156910497 0.258065481784771 0.656199912221176 -0.573183967275925 0.328765527670737 0.677655125241013 False False False False False False False 0 insufficient_or_context_specific +POLD3 0.214738114808619 0.258116900497684 0.656199912221176 0.125568785023471 0.515959975821821 0.799575139399206 0.262826978649411 1.0 -0.282308787430969 0.520167506827543 -0.186341276734985 0.607965799365606 -0.468650064165954 0.22144388111188 partial_or_other True False False False False False False 0 cross_species_direction_conflict +VPS52 -0.306101610521474 0.258308599091161 0.656237190870052 -0.368305827897227 0.169513426358089 0.549500385473966 0.574398182974335 1.0 -0.182115046120121 0.488138552825059 -0.223955048801759 0.298978659534816 -0.40607009492188 0.0866519301190438 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TXNDC11 -0.190038150263668 0.258492460067043 0.656237190870052 -0.110708105284502 0.511416174212127 0.796770426655916 -0.245811510436177 0.560983902319736 -0.578659073115482 0.102355373093555 -0.824470583551659 0.036634198569422 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDKAL1 0.213138232193658 0.258536537440021 0.656237190870052 0.288515319198564 0.1193643234399 0.499900248662619 0.7586571214675629 1.0 -0.143974340684932 0.722817832970844 -0.148685142384757 0.646086169997711 -0.292659483069688 0.376017824864771 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GLIDR 0.449170366297146 0.258544610183381 0.656237190870052 0.639376961810023 0.109571442365918 0.485461724087018 0.0680868372488537 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF865 -0.42782140186205 0.258566652208696 0.656237190870052 -0.656176885216168 0.0667067897322013 0.436862290339161 False False False False False False False 0 insufficient_or_context_specific +ZNF440 0.342687942910217 0.259193880934733 0.657234328579116 0.338359597218842 0.266196802706943 0.628607882572111 True False False False False False False 0 insufficient_or_context_specific +USP18 -0.515177327200773 0.259208537999947 0.657234328579116 -0.289903155442175 0.534804648346375 0.810930391494977 0.515625468121469 0.18903492674382 -0.235379944583142 0.470526158925892 0.280245523538327 0.447701305132782 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DCAF17 0.27630112769863 0.259412190467118 0.657592774778351 0.26197900332281 0.287035028167685 0.647335588595963 0.267576171379516 0.0252373133758776 2.0 -0.10718389710599 0.797534389204034 -0.189613844782813 0.529021018882975 -0.296797741888803 0.362553189555535 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SAR1B -0.216973418464457 0.259523542777745 0.657717130256225 -0.0921875282486472 0.635266536672013 0.861847932958146 -0.157449139977631 0.770405194413138 0.7898807788013 0.0622729642642479 0.632431638823669 0.138985771366095 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM18 -0.489857632790508 0.259656688136847 0.657896643472243 -0.718553216816901 0.0878678751537872 0.468622105620855 -0.201880333782251 0.637962343051058 0.663228628436422 0.0446720919052227 0.461348294654171 0.180115325786947 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC027644.4 -0.276054447980573 0.260249657921774 0.658797145150104 -0.295913408100058 0.224460673244758 0.596340158056908 False False False False False False False 0 insufficient_or_context_specific +AP5Z1 -0.353887299575468 0.260261687101826 0.658797145150104 -0.373518030553538 0.232878325415022 0.602604162857471 0.348646684883979 1.0 0.0127654777534166 0.980628573338479 -0.540698534377132 0.12803586638623 -0.527933056623715 0.165684750828936 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP2C8 -0.846083838753584 0.260649537220924 0.659207826690317 -0.859322166430193 0.253601666337969 0.618991529980024 False False False False False False False 0 insufficient_or_context_specific +SPAG16 0.223426405663855 0.260728773092458 0.659207826690317 0.408630602149158 0.0398771669834733 0.381707279248877 True False False False False False False 0 insufficient_or_context_specific +NEGR1 0.720230828394809 0.260742868976953 0.659207826690317 1.25051280403422 0.0461311660823505 0.398473305589448 0.117180778247537 0.356380780895267 0.169377178075815 3.0 True False False False False False False 0 insufficient_or_context_specific +PANK2 -0.170899067422097 0.260805281151868 0.659207826690317 -0.19864872779025 0.185690599519989 0.56775396895769 0.539937771103731 1.0 0.0676516205726075 0.836933962693437 -0.502269923107839 0.0433091985701503 -0.434618302535231 0.0873068221070978 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C9ORF3 0.228622955231287 0.26090254708457 0.659207826690317 0.0772729790413153 0.716186326369182 0.897613394326427 0.176542247772873 0.347702697951378 2.0 True False False False False False False 0 insufficient_or_context_specific +ZFC3H1 -0.217523900152807 0.260920054720039 0.659207826690317 -0.104409029263539 0.595750159377038 0.840863973731786 0.376662385862331 0.204544353723281 -0.352775500452043 0.174815874516892 0.0238868854102872 0.941040864830435 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNHG25 -0.450053186241904 0.260955126245801 0.659207826690317 -0.153695996776073 0.70319166517533 0.891640364000942 0.318702072087963 0.296510024922624 2.0 False False False False False False False 0 insufficient_or_context_specific +MICU3 0.196246415512769 0.261206928451523 0.659207826690317 0.282794586004764 0.0988396137494163 0.478125555523304 -0.32628859133937 0.361077875409092 -0.713229772824576 0.0354818712239347 -1.03951836416395 0.0110244589753655 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SPG11 -0.128981552972031 0.261232104283155 0.659207826690317 -0.075075587484644 0.510075087091953 0.796519013040946 0.170258246102742 0.544056365712869 -0.468813458505459 0.0497664296548152 -0.298555212402716 0.223233953707952 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TNFRSF14 -0.388512324823482 0.261463773250997 0.659207826690317 -0.478679579972139 0.16379376254114 0.544850245278 0.517182047068921 1.0 0.242539246238993 0.692046018169297 -0.505922801250302 0.259579293321707 -0.263383555011309 0.635373595871688 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTPBP10 0.214308633567029 0.261470968038436 0.659207826690317 0.230438467699494 0.227160502201833 0.599238613585423 -0.178836422853195 0.619034057486679 -0.0749083636959996 0.804265007326295 -0.253744786549194 0.404332741656535 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LETMD1 -0.188231026868565 0.261567446331458 0.659207826690317 -0.214434559181609 0.200502612791391 0.575559158741573 -0.286677173072283 0.220638627693788 0.0085024318175876 0.971755906926751 -0.278174741254695 0.19838951426909 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SSBP2 0.318336896508051 0.261779693707933 0.659207826690317 0.537487400440133 0.0518662949845661 0.411906134371584 0.266030548791285 1.0 -0.326302587556305 0.427896022950611 -0.600782155832535 0.0947053629098445 -0.92708474338884 0.0271834340774746 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GOLGA8B -0.570234227416249 0.261792876884607 0.659207826690317 -0.573312079699019 0.259370489786204 0.622885940784012 False False False False False False False 0 insufficient_or_context_specific +TBC1D9 -0.301515884091449 0.261803317512273 0.659207826690317 -0.104951028823418 0.701265611834999 0.891163043182575 1.58684842141482 0.110159000711382 -0.767600144200007 0.247262947735665 0.819248277214815 0.417455886564643 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNEP1R1 -0.405641871876742 0.261805742945289 0.659207826690317 -0.378334536564596 0.297159048325378 0.654889895570548 -0.105977389609908 0.741663686047195 0.0524303077755394 0.843447849333249 -0.0535470818343685 0.854977905473316 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APIP 0.438025599621609 0.261932485080168 0.659207826690317 0.689737155043402 0.0794530689074031 0.459160525051927 0.0516637595824784 1.0 -0.725863987219815 0.0698349278948489 0.765516715698841 0.0338829670863256 0.0396527284790257 0.923571200108767 reversed True False False False False False False 0 cross_species_direction_conflict +UIMC1 0.154166116055157 0.261940344612168 0.659207826690317 0.205409048941238 0.131581892662111 0.517896578143491 0.862296987087395 1.0 -0.351412260277461 0.314518642577488 -0.226649790309294 0.451641746207305 -0.578062050586755 0.081092163729848 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KIAA1841 -0.330694102702554 0.261952135223031 0.659207826690317 -0.0472018766964291 0.873364489783515 0.959263070839262 False False False False False False False 0 insufficient_or_context_specific +ATP6V0A2 -0.241191404826377 0.26203870576827 0.659207826690317 -0.260583785113742 0.225073500369494 0.597066838417367 -0.197963836176969 0.468839098744151 -0.0891207421187922 0.709152901316051 -0.287084578295761 0.230129617520697 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TFG 0.210249752217474 0.262228114100789 0.659268438785942 0.381324004547126 0.0304015543473859 0.374622380904833 0.0524687859823639 1.0 -0.278436191892147 0.508847535439478 0.747265406767228 0.0408438626730751 0.46882921487508 0.193450268572168 partial_or_other True False False False False False False 0 cross_species_direction_conflict +U91319.1 -0.73228431767629 0.262258708363417 0.659268438785942 -0.902379378638055 0.163892609473726 0.544850245278 False False False False False False False 0 insufficient_or_context_specific +H2AFY 0.191310977197958 0.262589706238699 0.659786320435075 0.250429100866864 0.136659915045564 0.523136620282319 -0.118972761902013 0.671849522921178 -0.0100062599142112 0.969207883746069 -0.128979021816224 0.59159560995756 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RCC1 -0.337312089610523 0.262945063522446 0.66052200349036 -0.0216336164057482 0.943458438373579 0.984366565940656 1.08836491340281 0.0071625868735323 -1.36507772287841 0.0019014954372257 -0.276712809475597 0.438556234282304 reversed False False False False False False False 0 insufficient_or_context_specific +HNRNPA3 0.200951008440937 0.263212207022228 0.660791462627988 0.285024909681256 0.10935085418497 0.485176912870447 True False False False False False False 0 insufficient_or_context_specific +GALNT2 -0.376192922533977 0.263240092045209 0.660791462627988 -0.324525824753686 0.33583695771721 0.684510926559518 0.647846928581405 1.28912238002193 2.0 -0.226874060063861 0.356504877464455 0.14556828331345 0.493045756929981 -0.0813057767504103 0.735998367147286 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GUK1 -0.403920641231192 0.26345692753113 0.661160443873668 -0.27799528707267 0.450494072081948 0.763947905803589 0.0904398959750208 0.9943990400144741 2.0 0.0224024369911838 0.942068767466077 0.207025048614707 0.315440958583111 0.229427485605891 0.295128613816256 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF354A -0.360899932138426 0.263512326938851 0.661160443873668 -0.0307226204317533 0.927006829986913 0.979087152943213 False False False False False False False 0 insufficient_or_context_specific +RASSF8 0.343708937425991 0.263632520854364 0.661171621695169 0.62995174845828 0.0356831587572172 0.37720666979567 0.7181377826944 0.164201960981645 0.104287329592417 3.0 -0.108571258638731 0.740387399367258 -0.204649274355725 0.413523352120303 -0.313220532994456 0.231937134046773 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MOK -0.270263552665022 0.263642027593925 0.661171621695169 -0.2997754616475 0.21407453119801 0.587064775455755 0.562962940754933 1.0 -0.174573421969503 0.8890677464436 0.116391423332895 0.898541833049844 -0.0581819986366081 0.956201636867624 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASH2L -0.199834188831741 0.263915535370625 0.661543262688286 -0.28664229078431 0.0986789195338138 0.478125555523304 0.08946089494347 0.798577393174677 -0.301437931915482 0.229839622446148 -0.211977036972012 0.440315680202867 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASL -0.758021055847433 0.264039582959189 0.661564835355403 -0.843534169568201 0.211422585394024 0.583597855241824 -1.44087669164499 0.0194526316654516 1.419424274459 0.0162140879232571 -0.0214524171859875 0.973378738883964 reversed False False False False False False False 0 insufficient_or_context_specific +C9ORF78 -0.397048149620014 0.264129386623017 0.661564835355403 -0.371312778740778 0.298464031391933 0.656568335095699 False False False False False False False 0 insufficient_or_context_specific +HEATR6 0.305890550990439 0.264174781763438 0.661564835355403 0.316311054226932 0.24852940468021 0.614215233681543 -0.251148272530048 0.448586650946601 -0.210911470884397 0.444332987743193 -0.462059743414444 0.122104384902603 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GORAB -0.296388212691274 0.264298066605559 0.661716620161606 -0.242241772754089 0.365114951277288 0.706387878106228 0.335715605477587 1.0 0.0599512062111001 0.914827918728458 -0.588022581318888 0.114802234945592 -0.528071375107788 0.199493137950498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYO9B -0.283736331241547 0.264645097802182 0.661907208672026 -0.430086580340752 0.0909612034312488 0.472234212482528 0.475606936732055 1.0 0.322856067441152 0.585950251307183 -0.671635645014152 0.154160694223555 -0.348779577573 0.509920841128382 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF6 0.455505069546426 0.264740282966442 0.661907208672026 -0.0016480022050772 0.997176317835382 0.998795540446485 0.0448486128914998 0.885130826731918 0.133934125964014 0.529114526875291 0.178782738855514 0.427414876339933 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC090114.2 -0.488643829748078 0.264787098590435 0.661907208672026 -0.64837189036241 0.131880846915567 0.518197983526071 False False False False False False False 0 insufficient_or_context_specific +H2AFY2 -0.335265028550262 0.264809961281572 0.661907208672026 0.248757248766652 0.400735644201218 0.730608696937787 0.414554512207738 0.205814568733279 -0.33270660248043 0.23139295290625 0.0818479097273081 0.811697286526188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCTD21-AS1 -0.630206736052348 0.264813037453176 0.661907208672026 -0.955514313911115 0.0842830129959265 0.464779732481256 0.592626433956295 1.0 False False False False False False False 0 insufficient_or_context_specific +RABL3 0.27557488936984 0.265429525318185 0.663207022259726 0.111820331172721 0.650277687168998 0.869901306439436 -0.247368583756787 0.553409182338267 -0.493223648093826 0.148716249781009 -0.740592231850612 0.056599422470582 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM232 0.297760837493804 0.265458692562001 0.663207022259726 0.207467502148703 0.437456957927814 0.754535640189682 True False False False False False False 0 insufficient_or_context_specific +RARS 0.224615578346582 0.265691192104579 0.663489194520872 -0.0181608881476848 0.926854450944549 0.979087152943213 0.919560881604934 1.0 0.368188673860113 0.296682786383099 -0.189111269515367 0.520926623957089 0.179077404344746 0.595356573835764 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATG13 0.212786397439382 0.265777739955977 0.663533076012108 0.0120848188060631 0.948340155513074 0.986642915209573 0.5526263034277271 0.650506375888935 2.0 -0.432595420384699 0.191414915361149 0.0848209996450229 0.785076279150623 -0.347774420739677 0.252690094700539 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GALNT16 -0.559020566371333 0.265954922762165 0.663681248836326 -0.433930042306207 0.39213872655192 0.724317822766824 0.0915144042391387 0.490251287100844 2.0 False False False False False False False 0 insufficient_or_context_specific +SLC22A1 -0.87228223578144 0.266033435786094 0.663681248836326 -0.860949100219237 0.272974726561974 0.636920920009132 -0.844897236804795 0.0632156162518956 0.884086961146812 0.0388353369874604 0.0391897243420176 0.934929016521663 reversed False False False False False False False 0 insufficient_or_context_specific +TRMT44 -0.24152842472445 0.26607324894153 0.663681248836326 -0.253650603785437 0.242120851266447 0.608802057364402 0.16539810621987 0.552681517126567 2.0 0.441374979862396 0.258472942115605 -0.692989930949176 0.0467846279681387 -0.25161495108678 0.507979726353779 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SAFB2 -0.221130338539378 0.266214253534935 0.663681248836326 -0.309816274631933 0.112740909144312 0.492070491420275 0.779959601251763 1.0 -0.23213982618044 0.47133043795982 -0.564033113177442 0.0503267769833071 -0.796172939357882 0.0168931136017645 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POU6F2 -0.699166269648603 0.266370712696706 0.663878032595554 -0.751948343789102 0.23094893287659 0.601518427890281 False False False False False False False 0 insufficient_or_context_specific +TNPO2 -0.204966678653187 0.266451845372084 0.663878032595554 -0.30306307298108 0.0857722488605645 0.467503293000484 0.322288089212118 0.339773283392283 -0.444120920564505 0.12732969543146 -0.121832831352387 0.715134491056259 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MPP5 -0.195174124741551 0.266481824411817 0.663878032595554 -0.139939097436704 0.428536363625523 0.748096383458709 -0.253272026962993 0.576119080251152 0.0531712576663845 0.898538419616309 -0.200100769296609 0.620495207383064 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCB11 -0.631055370654594 0.266860630890371 0.664508146448241 -0.909180282188644 0.105995742771828 0.483261130274234 -1.08281564778554 0.0281287559357838 1.22965017150424 0.0121406469736717 0.1468345237187 0.756201618090506 reversed False False False False False False False 0 insufficient_or_context_specific +IGF1R 0.248660231924102 0.267043582790258 0.664538816849309 0.237677619802924 0.288366327430485 0.648310091921223 0.497955102419168 0.219827539498718 0.128765359133822 3.0 -0.149719286031732 0.637962343051058 0.242791409107161 0.326146528483505 0.0930721230754287 0.747383997212863 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNHIT1 -0.344607672198477 0.267067127118524 0.664538816849309 -0.577890332685913 0.0432400855630227 0.391724217341578 -0.301219990079862 0.303145269966327 0.222336163534311 0.373832502368169 -0.0788838265455508 0.788546771930558 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM220-AS1 -0.458605899078881 0.267180449643386 0.664538816849309 -0.543436114228896 0.18929869068599 0.569886897607216 0.363065445997629 1.0 False False False False False False False 0 insufficient_or_context_specific +OTUB1 0.415503138583513 0.267195533198083 0.664538816849309 0.376192927171944 0.315127540783406 0.667425591893922 -0.0568889693225554 0.867994151464597 0.415921127404569 0.0810809258185391 0.359032158082013 0.151492040921503 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PPIG -0.153184033130357 0.26745157034733 0.664538816849309 -0.17552338716949 0.200217060008446 0.575556382365159 0.30439868632723 0.328535644461382 0.0251994976127222 0.932446019242114 0.329598183939952 0.243942941237066 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRKAR2A -0.170847228454007 0.267476480653571 0.664538816849309 0.02329879306035 0.887714335594479 0.963978728802596 0.5685317698468261 1.0 -0.686712557391299 0.0195248070153028 0.905888171009867 0.0039566153281876 0.219175613618568 0.380013187859913 reversed False False False False False False False 0 insufficient_or_context_specific +TBXAS1 0.477729266742328 0.267522535177148 0.664538816849309 -0.031251951433735 0.943048601973815 0.984366565940656 0.471755187607221 0.850426421348747 2.0 0.485685161059821 0.488335954733525 -1.03908774314376 0.0712633121987459 -0.553402582083943 0.412974340412972 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTF2IRD2 -0.300450737264794 0.267628248649674 0.664538816849309 -0.468452205417686 0.0817078104227718 0.461568251708734 -0.315852845729296 0.564433089727978 -0.180431457035715 0.693163553930913 -0.496284302765011 0.294689633629552 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SGMS2 -0.706710540128095 0.268222389829127 0.665388155971787 -0.690543209634517 0.281784809431164 0.64315368591277 0.585781001402031 1.0 -0.548770854935584 0.287056464772636 0.97072779484968 0.0339503617718795 0.421956939914096 0.346020114135014 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFAND5 0.474710975222869 0.268305308641594 0.665437502616385 0.0153966701712115 0.971200679860652 0.992040338141303 0.527618550772147 0.0891415182692543 0.0535288816647746 3.0 -0.0058844031069059 0.987103209694911 0.177631886238652 0.45288130741675 0.171747483131747 0.500533801095079 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRC1 0.722577203630465 0.268425759768716 0.665441341752401 0.257197485416745 0.68764757210507 0.884451344908836 -0.0183211387378716 0.96359833642626 0.463400822682562 0.094009695239409 0.44507968394469 0.126010540375426 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IQCE -0.280049591044455 0.268698117848274 0.665908127492694 -0.162665203833703 0.535034955339194 0.810930391494977 -0.434637131589557 0.289366410868311 -0.361822793518267 0.309128761712678 -0.796459925107824 0.0487567517059587 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MORC4 0.28665736352959 0.268788144365399 0.665908127492694 0.434908929321569 0.0907191667579005 0.472234212482528 0.0332384060128589 1.0 True False False False False False False 0 insufficient_or_context_specific +MTG2 -0.273803596089168 0.268810422369186 0.665908127492694 -0.312774910947743 0.203802171693159 0.577025563405608 -0.268852016586008 0.299721284166001 -0.345646623863687 0.127659683438118 -0.614498640449696 0.023146255290413 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FKRP -0.32802423005055 0.268895731135911 0.665963201813969 -0.714797687735173 0.0084598252570499 0.289323392278623 0.156053102262439 0.485988946958867 -0.38647003910607 0.0486550083734789 -0.230416936843631 0.241237050540591 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBB 0.526210829042319 0.269178638034182 0.666195044623745 0.611723779226426 0.199366930048344 0.575122356864606 0.5639685686584829 1.0 True False False False False False False 0 insufficient_or_context_specific +CEP95 0.171180570204182 0.269487500384239 0.666646914024555 0.0566323228772699 0.713454991715967 0.895572203369062 -0.285510193834454 0.532227623439228 -0.348119415160285 0.348995653273012 -0.633629608994739 0.119613937516882 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ADAMTS17 -0.430997637194042 0.269876570103412 0.667222685933312 -0.659775808470205 0.080392601925294 0.460352677246087 0.7621554826389849 0.282613914443729 2.0 False False False False False False False 0 insufficient_or_context_specific +ARSA -0.491561204843966 0.270014229859489 0.667222685933312 -0.52085772584475 0.241085505422026 0.608360603787226 0.0481691484408365 0.909706000743012 0.32677944791623 0.23740734860177 0.374948596357066 0.211406928344212 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC38A2 0.305154015782378 0.270383516463714 0.667448704252917 0.111561163337415 0.702900658883074 0.891640364000942 0.264860802495336 0.260487816818979 2.0 -0.078776528470149 0.8140075709968 0.0899924108829207 0.724863774561987 0.0112158824127718 0.971277478566388 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MOGAT1 -0.922480592656515 0.270417672439954 0.667448704252917 -1.32108410388796 0.0996203822140489 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +TANGO6 -0.142998525603383 0.27055032639574 0.667448704252917 -0.106864893413145 0.41024143160921 0.735152897523944 -0.403269837337043 0.396071740154278 -0.159336506405827 0.708912326459481 -0.56260634374287 0.188758850947986 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IFT172 0.333790269019548 0.270688355928772 0.667448704252917 0.300881489357628 0.322736482690556 0.672877524535327 0.512389836710157 1.0 -0.0001056794174793 0.9996541557701 -0.538132550935135 0.0991658034213003 -0.538238230352614 0.119943256816968 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LDLRAD4 -0.253542855197207 0.270696661452074 0.667448704252917 -0.369386484590873 0.0982260810405605 0.478125555523304 -0.306698655206772 0.342070281107473 -0.135018784288729 0.633334934473725 -0.441717439495501 0.137284526578567 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CFH 0.225405749866501 0.271002199737512 0.667920191166134 0.197926821477214 0.336959223470491 0.685057785656405 0.8266324088287859 1.0 -0.580804484133952 0.0667885641616118 0.523738705585168 0.0697151824703974 -0.0570657785487845 0.863439262634971 reversed True False False False False False False 0 cross_species_direction_conflict +PVR -0.472980837742198 0.271014406038617 0.667920191166134 -0.636570791280862 0.131457341392169 0.517896578143491 0.137424682094523 0.811616405402168 -0.407512736641613 0.305974634747591 -0.27008805454709 0.559886416932334 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TUBGCP2 -0.208292312888239 0.271295298263921 0.668345347467533 -0.226622575277543 0.230665855750873 0.601518427890281 0.262850707558244 1.0 0.209337392155076 0.558989717020039 -0.724486569025745 0.022478701782624 -0.51514917687067 0.111911388162461 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HIRA -0.249798580664691 0.271313521428855 0.668345347467533 -0.236541748745709 0.297669384812326 0.655704853922082 -0.0553805838254866 0.893521538426301 -0.372465674940577 0.187328699144416 -0.427846258766064 0.160744370116826 partial_or_other False False False False False False False 0 insufficient_or_context_specific +A2M 0.377978590109979 0.271563852594326 0.668772996929307 0.291044032921434 0.406753346703065 0.733961461951707 True False False False False False False 0 insufficient_or_context_specific +SMO -0.426809495289503 0.271733634307489 0.668772996929307 -0.428402538584424 0.270899504973154 0.634885010767271 0.347065091450419 1.0 -0.0184843465287476 0.960462083902085 -0.263997586276308 0.293485298780139 -0.282481932805055 0.294212716086033 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LONP1 -0.292139302543379 0.271859102687957 0.668772996929307 -0.205662926522344 0.448267566747101 0.762495403530836 0.710167918705132 0.34203366682135 2.0 -0.0184528273047079 0.960760068523928 0.259309744670155 0.307315771456057 0.240856917365447 0.370595747946538 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APTR 0.254032893368956 0.271926807165116 0.668772996929307 0.278823558056054 0.230356827523266 0.601518427890281 0.0327827917634321 1.0 True False False False False False False 0 insufficient_or_context_specific +MRPL16 0.400585778248518 0.271998642751996 0.668772996929307 0.218472152322339 0.541008357142604 0.813507447752299 True False False False False False False 0 insufficient_or_context_specific +LINC01515 -0.550365658342316 0.272120950141351 0.668772996929307 -0.649374127971002 0.193705751749336 0.570885363891703 False False False False False False False 0 insufficient_or_context_specific +PAN2 -0.249973471928791 0.272203743875858 0.668772996929307 -0.156970560722024 0.493505085717281 0.786363265568912 -0.20105927698008 0.507323694706715 -0.709575497835194 0.0149966455263377 -0.910634774815274 0.0074677287896866 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FGD1 -0.290557726462105 0.272247238189256 0.668772996929307 -0.0503114626570589 0.858480885505151 0.956914759994669 0.550016961617019 0.164927451419479 -1.12622294993755 0.0073363816484618 -0.576205988320535 0.141391011251308 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KDM2B -0.252612369852361 0.272506359662359 0.669025090444419 -0.191939590903305 0.405950649705632 0.733444811508554 0.445168133071858 1.0 0.395905141787005 0.31674246922331 -0.836147730199302 0.0228832164823849 -0.440242588412297 0.246086727769006 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TSHZ1 0.29810365594999 0.272509102395294 0.669025090444419 0.0407847206341911 0.882987411937998 0.962778177759102 0.307408596786693 1.0 -0.220234229209018 0.614121189200058 0.419509370395901 0.209400097992276 0.199275141186883 0.596743098604647 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ABCB1 0.502096590987239 0.272599378902694 0.669025090444419 0.459707764933068 0.317337558539933 0.669290253214092 True False False False False False False 0 insufficient_or_context_specific +MBD1 -0.232220283117794 0.272725181409832 0.669025090444419 -0.22269811176432 0.293015186151728 0.651509781962399 0.0476783048940729 0.903525382640283 -0.409935379688026 0.133203320948199 -0.362257074793953 0.201779040227059 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MXD4 0.277731614949269 0.273054541420523 0.669025090444419 0.008964321416263 0.972799677435357 0.992221699150388 -0.140835497148679 0.629499404007157 0.547710785773868 0.0313454755612835 0.406875288625189 0.102073049825762 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF611 -0.229095091762084 0.273054563252634 0.669025090444419 0.0205821562450731 0.922121430132289 0.977317023541587 False False False False False False False 0 insufficient_or_context_specific +DYM 0.255024576785738 0.27314230641521 0.669025090444419 0.415436179090562 0.0695808339888744 0.441118118691429 0.330846820736262 1.0 -0.0608732577449899 0.893521538426301 0.371022697172162 0.220878659684542 0.310149439427172 0.340892056403477 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DAB2IP -0.280680218429858 0.273160273093736 0.669025090444419 -0.111517171612969 0.661173022053824 0.872692182378332 0.7988444284351199 1.0 0.196189697008011 0.418790181582913 -0.115495233080806 0.577759657724586 0.0806944639272047 0.731838353880848 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF266 -0.235992421831641 0.273320862983537 0.669025090444419 -0.253578947719206 0.237383131405279 0.605329180588419 False False False False False False False 0 insufficient_or_context_specific +ARHGAP42 -0.395393866429177 0.273342455447477 0.669025090444419 -0.10298132142594 0.776981942703705 0.922929913000972 -0.56243278410775 0.103041036609287 -0.07676970705736 0.817483029431813 -0.63920249116511 0.0564412064022385 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLBD2 -0.222204968797143 0.273385787511618 0.669025090444419 -0.0703238392038585 0.725155633580268 0.903065956515743 -0.402679335131083 0.290295933246025 0.60076403624089 0.077064328956213 0.198084701109807 0.580411485682836 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF75A -0.245950273229229 0.273423165621727 0.669025090444419 -0.430551214850116 0.0363010817396789 0.377876708853838 False False False False False False False 0 insufficient_or_context_specific +DEPDC7 -0.419775564634868 0.273448406357231 0.669025090444419 -0.558123698233133 0.144012075553149 0.53107911061479 -0.492892275820634 0.336972117421216 0.342166695863768 0.420174731089606 -0.150725579956866 0.765116677900228 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TADA3 -0.265724000966819 0.273481245384765 0.669025090444419 -0.315571233949983 0.191412061964459 0.570552915001293 -0.220812794269125 0.451802183309357 -0.254808511566238 0.293664566613361 -0.475621305835363 0.0794170333570016 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SOX5 0.251652292210443 0.273580583484008 0.669025090444419 0.368626702772745 0.100297615708665 0.478125555523304 0.4692359451181359 0.0435925845961769 0.399489126168444 3.0 -0.307212588948092 0.36218556900652 -0.067664366540214 0.831040170492243 -0.374876955488306 0.218622421471832 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GPBP1 0.155776518262616 0.273617194595473 0.669025090444419 0.104275852183397 0.460606336961783 0.768745132096508 -0.422845623916895 0.162528269234489 0.201795302221703 0.446134039141029 -0.221050321695192 0.429709601109914 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ENY2 0.259858609879 0.273990864651963 0.669309995509484 0.0740985313038779 0.759995247236477 0.915425158472589 -0.0964817830216434 0.821224349428667 -0.684948892623332 0.0383678869494149 -0.781430675644976 0.0337231711294006 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WDR48 0.232708578499663 0.274050682950133 0.669309995509484 0.233434695207578 0.272445133258796 0.636388432952736 -0.0866102037711334 0.786774563585364 -0.3317570790617 0.162779787695199 -0.418367282832833 0.104107005390769 partial_or_other True False False False False False False 0 cross_species_direction_conflict +INSIG1 -0.795728888237993 0.274209804224751 0.669543735662564 -0.985330436027435 0.174528265723531 0.556529577018737 -0.165669917642828 0.664077065473105 0.260550306915253 0.385701355411768 0.0948803892724248 0.785549174680743 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KMT5A -0.305503369166396 0.274300948394319 0.669596589703292 -0.0736086121977216 0.802026704349908 0.930781165449847 0.172464130992992 1.0 0.382369120596584 0.273538287992322 -0.127449107994332 0.67930771491384 0.254920012602253 0.429486678871231 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GCNT2 -0.650324489816416 0.274358292011408 0.669596589703292 -0.767789984181413 0.193603632992615 0.570885363891703 -0.549785692870692 0.35039354365475 0.268530611127589 0.597219529309378 -0.281255081743103 0.609202526308539 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FLOT1 -0.180676569121487 0.274532899139102 0.669664741099049 -0.120999438547462 0.460298383132789 0.768745132096508 0.8766141835960609 1.0 -0.346630034744896 0.351018789821951 -0.233962405055696 0.465787572977052 -0.580592439800592 0.0947803940217362 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CEACAM19 -0.415304663909005 0.274576497842184 0.669664741099049 -0.554071780988333 0.138787700921369 0.524067528467748 False False False False False False False 0 insufficient_or_context_specific +CBX7 0.259995208723362 0.274969213736902 0.670315355235194 0.218629021138224 0.355075631225145 0.698507269326454 0.951494866683947 0.643237235081506 2.0 -0.986026515123374 0.0155295141127712 0.416413309838413 0.209434770531013 -0.569613205284961 0.104170112294572 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PAQR5 -0.52524197097554 0.274972110451163 0.670315355235194 0.115143068985272 0.820316738992562 0.937879887725135 1.18428285772038 1.0 False False False False False False False 0 insufficient_or_context_specific +MYO1F -0.558389843710874 0.275069759250211 0.670315355235194 -0.781752591816029 0.114871561302049 0.492613299848511 1.46326132335725 0.122986494999844 -1.21874207018045 0.0879227110085213 0.244519253176799 0.82869638988022 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARMC1 0.361432513402742 0.275243825498775 0.670315355235194 -0.0490798744936213 0.886050624201394 0.963332560016303 -0.187151055284042 0.581803013365246 0.0320929003444776 0.919228163577521 -0.155058154939565 0.60757314233568 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IRAK1 -0.51482904138955 0.275332436752762 0.670315355235194 -0.224294497707127 0.643476003981222 0.865895953356327 0.438356950804669 1.0 0.0910669796288261 0.719931206645768 -0.1955201193609 0.314526392335604 -0.104453139732074 0.633737766435946 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC027237.3 0.734655080318773 0.275337317827949 0.670315355235194 -0.437686640010107 0.491766246410639 0.785674918408885 False False False False False False False 0 insufficient_or_context_specific +AL450384.2 0.248720212934024 0.275351174053328 0.670315355235194 0.451559438849322 0.0409261650272041 0.386838362002883 True False False False False False False 0 insufficient_or_context_specific +POLR2F -0.243584190434233 0.275639869740243 0.670442829737156 -0.258169591990158 0.246523803252143 0.611559754402286 0.0039727339177922 0.992788933773383 0.362520751044332 0.161923412832927 0.366493484962124 0.182831811661534 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RRAS2 0.18599661932875 0.275696390836729 0.670442829737156 0.150738306106008 0.383317415672361 0.718967005626005 0.352695910494762 0.358868578468676 2.0 -0.476850674049851 0.0876289555088389 0.621275730238001 0.0212247339241112 0.144425056188151 0.584439106486517 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SCD5 -0.311276948643005 0.275717021622524 0.670442829737156 -0.100290061793737 0.736351515908542 0.905895980536283 False False False False False False False 0 insufficient_or_context_specific +AC007216.4 0.236874170439827 0.275721042500353 0.670442829737156 -0.117298184019743 0.605923138945046 0.846820726734085 False False False False False False False 0 insufficient_or_context_specific +PPP1R3C -0.481882607601252 0.276564500138402 0.671759606564119 -0.301767391375638 0.500569943886518 0.790819493321426 -0.556914217609724 0.311895913931831 0.653643729684625 0.162779787695199 0.0967295120749005 0.863575969875012 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC75B -0.495678689578365 0.2765806980237 0.671759606564119 -0.343598606884351 0.457917734624475 0.767816418187074 False False False False False False False 0 insufficient_or_context_specific +RSPO2 -0.615523940685551 0.276674244831758 0.671832262404255 -0.486977193306178 0.393328987119412 0.725247545582736 0.28733314900413 1.0 False False False False False False False 0 insufficient_or_context_specific +LINC02210-CRHR1 0.570856209522946 0.276824192532322 0.672041808405669 -0.142409466482745 0.77785889862945 0.922929913000972 False False False False False False False 0 insufficient_or_context_specific +KPNA4 -0.193048695269415 0.277100384822146 0.672049872705933 -0.0459408967071659 0.799952396876282 0.929755328734014 0.180949597621451 0.520527589979208 -0.204249275105884 0.365896729565856 -0.0232996774844326 0.935154229512641 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FUK -0.387224088290074 0.277191202158568 0.672049872705933 -0.239591916840736 0.508906047799717 0.795764752589181 False False False False False False False 0 insufficient_or_context_specific +CCDC171 0.27834075914592 0.277318474310818 0.672049872705933 0.53420261462752 0.0327176098139043 0.375031405408838 0.111320073291006 0.0850681640464866 2.0 -0.201082673274855 0.664077065473105 -0.284331609613528 0.429245152204077 -0.485414282888383 0.20894864359327 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ATP6V1E1 0.236034460492972 0.277391935665717 0.672049872705933 -0.0721150924273468 0.740928012056578 0.908406208990048 -0.358661407064758 0.193063912577371 0.67315411307655 0.0148278682892874 0.314492706011793 0.212084316174488 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUP43 -0.249637035714707 0.277453466839562 0.672049872705933 -0.140444158281548 0.54932054218154 0.816365047001981 -0.346194816061401 0.66212669959598 -0.0164757408433461 0.981652498849907 -0.362670556904747 0.595332156027235 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UTP14C -0.444196544706974 0.277465555407764 0.672049872705933 -0.232049312701635 0.587809008711378 0.835274227991216 False False False False False False False 0 insufficient_or_context_specific +RPS24 0.238941071047089 0.277491252179502 0.672049872705933 0.210706745325218 0.339523567864679 0.687248817008297 0.322369690099292 0.0349198797062448 2.0 True False False False False False False 0 insufficient_or_context_specific +MT-CO2 -0.29509271693443 0.277591352043055 0.672049872705933 -0.156791863145784 0.564870165845329 0.823754286312897 -0.299344712090382 0.634937635038325 0.414304857131623 0.414520184003729 0.114960145041242 0.847595615916858 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BBS2 0.22502620030044 0.277782127765128 0.672279015977333 0.256296239047925 0.217096806867873 0.588776801158747 -0.0348149640218715 0.948056065676743 -0.395637710204664 0.254612537144987 -0.430452674226535 0.261068935427344 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNRF2 0.293332867794577 0.277877446190676 0.672279015977333 0.507004809074025 0.0600541061465713 0.428702672545977 -0.252220637554749 0.378455325125118 -0.116384827286899 0.649932247631125 -0.368605464841648 0.155327432511096 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NUGGC -0.746322542841248 0.278039172823224 0.672279015977333 -1.06340093718285 0.114650941029224 0.492613299848511 False False False False False False False 0 insufficient_or_context_specific +STXBP3 0.206191817820025 0.278151889996283 0.672279015977333 0.188418956621322 0.323637565240737 0.673691919126913 True False False False False False False 0 insufficient_or_context_specific +PHLPP1 -0.224411892655927 0.278178549329861 0.672279015977333 -0.298405093417652 0.150308647551429 0.533583468169136 0.620369010465183 0.951106844545861 2.0 -0.189690636450826 0.500662008062218 0.0667111459405477 0.787516986512375 -0.122979490510278 0.635040024419102 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADAM23 -0.575452874284066 0.278195108780275 0.672279015977333 -0.401144161075115 0.456217488452265 0.767060408474954 0.581503307370462 0.113424959313384 -0.158453630217475 0.622725296135771 0.423049677152987 0.213412510532617 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP6V1B2 0.386213268659888 0.27842310613704 0.672540422892309 -0.0505947812375302 0.887301818452147 0.963799650125285 0.256260740384064 1.0 0.197460622211848 0.5490974722448 0.256380809456892 0.321595639017921 0.45384143166874 0.111943072618747 partial_or_other False False False False False False False 0 insufficient_or_context_specific +QRSL1 0.306928175286944 0.278740606171719 0.672980407034304 0.347877544519272 0.219768823993837 0.592069212484543 -0.255394363001714 0.646455831565373 0.0227030319820937 0.962827865541957 -0.23269133101962 0.633876409141623 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC00159 0.382761852247632 0.279186362178864 0.673526682356923 0.552266895358037 0.117692920900099 0.497239639401058 True False False False False False False 0 insufficient_or_context_specific +GNA14-AS1 0.600549171314479 0.279242997125563 0.673526682356923 0.739471794617434 0.182105161968329 0.56456240235188 0.744709172986452 1.0 True False False False False False False 0 insufficient_or_context_specific +COX20 0.357124372528578 0.279285521338593 0.673526682356923 -0.0052048697749085 0.986800109028113 0.995855051722311 0.321514067838305 0.527156421398648 0.362410187526703 0.333554598190353 0.683924255365008 0.117298105405805 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ESD 0.325470986180667 0.279349321301414 0.673526682356923 0.411348370011378 0.171619028027449 0.552641842639707 0.0298964704349585 1.0 True False False False False False False 0 insufficient_or_context_specific +POU2F1 0.211520233376086 0.279593873698763 0.673526682356923 0.273403654932054 0.16114139871525 0.543541307772207 -0.468920010437504 0.175127035109465 0.116716250063778 0.710762239338489 -0.352203760373726 0.267091391222535 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL117336.3 0.268009299198465 0.27961952065072 0.673526682356923 0.217842826852462 0.380009873711684 0.716454329758565 True False False False False False False 0 insufficient_or_context_specific +CEP104 0.182332436636729 0.279626311361783 0.673526682356923 0.0414759910510316 0.809904109131663 0.933206109812517 -0.177524181027237 0.642701993569379 -0.0080274122754838 0.982165040595014 -0.185551593302721 0.57585981979015 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC00907 -0.847815838575284 0.27974166988938 0.673526682356923 -0.475760221759437 0.552577450339952 0.819071644755648 False False False False False False False 0 insufficient_or_context_specific +PARP16 -0.258891609176611 0.280184455122521 0.673526682356923 -0.398851829190275 0.0876580154898374 0.468622105620855 0.396334078254442 1.0 -0.245711499661449 0.534128553453078 -0.107571197972345 0.747464907490973 -0.353282697633795 0.301761940458863 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF423 -0.332940664036994 0.280247237286394 0.673526682356923 -0.213018652929846 0.488888105151561 0.783735289126964 0.294219356741442 1.0 False False False False False False False 0 insufficient_or_context_specific +AC022784.6 -0.920708393122782 0.280306315249098 0.673526682356923 -0.954583921123048 0.261782443813774 0.624330278962413 False False False False False False False 0 insufficient_or_context_specific +MAPK8IP3 -0.222860651887055 0.280329872105893 0.673526682356923 -0.25239668392981 0.216394505885964 0.588192212595831 -0.217723534057504 0.501726388375211 -0.813976857227913 0.0112464277878152 -1.03170039128542 0.0058031648159472 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IFT122 0.223016765256563 0.280333109847584 0.673526682356923 -0.0247846592026432 0.903541486274787 0.969539398249544 0.536821307318589 1.0 0.183107511584262 0.72780457089062 0.200527856286887 0.608702142739624 0.383635367871149 0.364222735478041 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC22A25 -0.918547637441703 0.280386229419202 0.673526682356923 -1.11537109146089 0.18815221199179 0.56929178900529 False False False False False False False 0 insufficient_or_context_specific +GIPC2 -0.396557366327581 0.280434106425557 0.673526682356923 -0.492769855037455 0.176651680632202 0.55857695241533 -0.0244859542481167 0.980581669633894 -0.63959372846127 0.326316041603655 -0.664079682709387 0.376867152352876 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERCC4 0.308229512230629 0.280818462064766 0.673643719986426 -0.0184816662431036 0.947810663472612 0.986298539813112 0.466483838557993 1.0 -0.232432442125896 0.602051276048176 0.122160188440535 0.73471583957959 -0.11027225368536 0.790656428951788 partial_or_other False False False False False False False 0 insufficient_or_context_specific +THUMPD3 -0.349564706158365 0.280818761843632 0.673643719986426 -0.112688223209919 0.731068838229068 0.904431845923655 0.163215587128956 0.703287712968309 -0.350999436651285 0.267000701906002 -0.187783849522329 0.618330297773438 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NF2 -0.198053001735284 0.280873837047194 0.673643719986426 -0.211246233631284 0.248318702243385 0.614136532744356 0.494056035004966 1.0 -0.200183535643524 0.397867237724931 -0.559285727437991 0.0164066152720498 -0.759469263081514 0.0062108910003268 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLAA -0.259323984004512 0.280920173779424 0.673643719986426 -0.222075175201366 0.356107926332742 0.699495346273692 -0.159195410896426 0.583602118421562 0.326755660155368 0.15631878301239 0.167560249258942 0.502344794099087 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL34-AS1 0.394507362309977 0.280929465722697 0.673643719986426 0.297622710289375 0.415117273165081 0.737098102737237 True False False False False False False 0 insufficient_or_context_specific +NNMT 0.411597674533604 0.28115213628527 0.673708845130066 -0.0047549838633575 0.990072179566759 0.996896452948454 0.558610154198921 1.08556340318806 2.0 -0.850724862631261 0.0171356654409513 0.818772855422596 0.0152769417367606 -0.031952007208665 0.928497034280132 reversed False False False False False False False 0 insufficient_or_context_specific +AL049650.1 0.461630940157008 0.281277746771334 0.673708845130066 0.533495970799879 0.215856816422241 0.587852789707652 True False False False False False False 0 insufficient_or_context_specific +ERBB2 -0.264882096960187 0.281479687797292 0.673708845130066 -0.347632422923907 0.151292373315432 0.534164555672079 -0.16921949977591 0.639531240719788 -0.482958571196903 0.0975789966571976 -0.652178070972813 0.0464966412330478 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC146 0.253157499129445 0.281584525527311 0.673708845130066 0.211930295334073 0.369372282698141 0.709345639075664 True False False False False False False 0 insufficient_or_context_specific +TRIM13 0.203688039936359 0.281594704449595 0.673708845130066 0.0790827408236975 0.676238600383499 0.879146834479876 True False False False False False False 0 insufficient_or_context_specific +MT-ND6 0.25732483702206 0.281642179365071 0.673708845130066 -0.126531334922647 0.593489019349442 0.839391435538032 -0.419953017987743 0.251783128316293 -0.678523452215149 0.0489796245256278 -1.09847647020289 0.0091184800597058 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAMSAP3 -0.727287880771804 0.281690898520283 0.673708845130066 -0.837999479126485 0.211207997695676 0.583586702354765 -0.274464813824941 0.499317892252322 -0.0319538888442954 0.932666004342199 -0.306418702669236 0.387815061874195 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC46A3 0.36612794599402 0.281722348100894 0.673708845130066 0.287965260020069 0.397550714504613 0.728185510817911 0.578090525954204 0.0124286112236202 2.0 -0.0607814791019611 0.923056752905704 -0.434118922520641 0.299796915250318 -0.494900401622602 0.277218137289545 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC092378.1 -0.321284453816006 0.281794250108054 0.673728191268305 -0.528134556936783 0.0785866443657036 0.457322349441485 False False False False False False False 0 insufficient_or_context_specific +PSMD6-AS2 0.298856959641178 0.281917737422894 0.673870833532017 0.0992668572084273 0.722411452500634 0.90145610631151 True False False False False False False 0 insufficient_or_context_specific +PWRN1 0.433285335106549 0.282011675645124 0.673942795713269 0.501543493101786 0.214652307829098 0.587852789707652 True False False False False False False 0 insufficient_or_context_specific +AC087482.1 -0.607813998101015 0.282223435280495 0.674013898193165 -0.465420286125673 0.413379079945634 0.735996007768297 False False False False False False False 0 insufficient_or_context_specific +HSD17B13 -0.390785595325946 0.282326469773121 0.674013898193165 -0.18927069323222 0.622491257133139 0.855079408706246 0.0764447730777644 0.919581755945232 0.527154475481597 0.304212865471568 0.603599248559362 0.263301726992422 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RARRES1 0.470651135165857 0.282508343597389 0.674013898193165 0.665889133470648 0.122563796209719 0.5038394341269 0.32654823725383 1.93473779385862 0.0664797814777047 3.0 -1.76236765219031 0.0151939671706083 2.54749236043864 0.0019872992848927 0.785124708248333 0.163282042719555 reversed True False False False False False False 0 cross_species_direction_conflict +KCNAB2 -0.486063429285132 0.282562909025031 0.674013898193165 -0.612928623534379 0.165701474677754 0.545468009482397 False False False False False False False 0 insufficient_or_context_specific +ZNF461 -0.304773679719235 0.282672006096048 0.674013898193165 -0.182644583006285 0.520478938512321 0.801118945922776 0.287732724672995 1.0 False False False False False False False 0 insufficient_or_context_specific +AL391987.2 -0.393593768768893 0.282746050648601 0.674013898193165 0.172264191914723 0.641771984378656 0.864815393882559 False False False False False False False 0 insufficient_or_context_specific +TBC1D10B -0.282459002275829 0.282788763603135 0.674013898193165 -0.287489377208729 0.274026328054379 0.637623822254105 0.495529658258678 0.0629657500260124 -0.613367921092588 0.0170295936873771 -0.11783826283391 0.654202486403616 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PKN2-AS1 0.327315180186445 0.282810822722753 0.674013898193165 0.524285161021688 0.0868129950580775 0.468116241993454 True False False False False False False 0 insufficient_or_context_specific +TRAK1 -0.170998817407738 0.282922561229758 0.674013898193165 -0.0710859276409517 0.644474362052624 0.866251949351307 1.54646489897137 1.07466349780455 2.0 -0.0038794333475999 0.992110993471489 -0.428194985385355 0.0853352416699177 -0.432074418732955 0.0954633816120068 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RMC1 -0.244554212506689 0.282977905700069 0.674013898193165 -0.289183730873372 0.201595559488864 0.576305465780752 1.02380716505655 1.0 0.129316636218952 0.669003589846265 -0.674512579720986 0.0135366183178155 -0.545195943502034 0.0451822601836641 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARIH2 -0.136370302665494 0.283079061264618 0.674052487332395 -0.168636300722437 0.181229312981701 0.563931354689301 0.0363457169578309 0.89847992406416 -0.225455978194465 0.244076406152203 -0.189110261236634 0.36034068656177 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HIC2 -0.2976773202127 0.283159889629763 0.674092923271936 -0.0707137588544642 0.800098426532443 0.929822695358232 0.277222180272857 0.591062660438741 -1.01328157645077 0.0254881298413721 -0.736059396177912 0.126073370134676 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IFT52 -0.249753235682579 0.283540867333768 0.67419136040224 -0.458545668865539 0.0349464130867017 0.37720666979567 2.44620769336598 1.0 0.134176696243696 0.6579015990307 0.198774570091377 0.388838893267724 0.332951266335073 0.182293177338629 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM163B -0.426043362774876 0.283675095352426 0.67419136040224 -0.361001740623184 0.369477458838179 0.709345639075664 0.499379008841984 0.342969187971533 2.0 False False False False False False False 0 insufficient_or_context_specific +POLR3B -0.260277720907091 0.283701075941529 0.67419136040224 0.0622921566286615 0.793195797192987 0.927620871373898 0.228672811846359 0.681579896863769 -0.0304268523758956 0.948193148017817 0.198245959470464 0.686635350809716 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYMPK -0.211390905346013 0.28371429094963 0.67419136040224 -0.268239558223056 0.168274978648506 0.54784064895804 0.281229712871282 0.254467033279307 2.0 -0.0561217834324486 0.847877126889398 -0.0456270097017705 0.840000107142249 -0.101748793134219 0.659788869519024 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAT -0.309851650430252 0.283824164731875 0.67419136040224 -0.363578547345408 0.208447917091731 0.580837452798758 -0.80837223908271 0.196752049273969 1.53243899851127 0.0171388557501631 0.724066759428556 0.209809616739864 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITGA4 -0.578130551915749 0.283904578412015 0.67419136040224 -0.276056921462297 0.609705170042803 0.848013066172034 0.415758242486406 0.628313222217819 -1.39281263627331 0.0539453727060128 -0.977054393786901 0.247369938682454 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC9A1 -0.285968641236555 0.283929386456973 0.67419136040224 -0.261623230598516 0.327809740933162 0.676904996043874 1.16388373899896 0.598209933218405 2.0 0.193971152040617 0.5164987793395 -0.123444863871503 0.618153875154994 0.0705262881691135 0.807453178264077 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VTA1 0.211484768679635 0.284002667305244 0.67419136040224 0.0349244991392254 0.862176575535419 0.957822965712685 0.287648372292324 1.0 -0.112643471378936 0.75755758820967 0.224496504736826 0.383395069845939 0.11185303335789 0.71610306801032 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CHDH -0.56540165835315 0.28403136683739 0.67419136040224 -0.63003075321798 0.231022758354264 0.601518427890281 -0.730758499069633 0.0944068446054614 1.0865142764468 0.013876209066282 0.355755777377166 0.3687554526822 reversed False False False False False False False 0 insufficient_or_context_specific +SP2-AS1 0.398715072477402 0.284274998297963 0.674251304622347 0.571196573935325 0.132698071573527 0.518983148534855 True False False False False False False 0 insufficient_or_context_specific +STX18-AS1 -0.196501592385328 0.284296412373882 0.674251304622347 -0.118323142663657 0.520235737536886 0.801118945922776 False False False False False False False 0 insufficient_or_context_specific +HK1 -0.251404340696719 0.284369943352714 0.674251304622347 0.061432625187977 0.796785185108956 0.928937498275217 0.8349202731964309 0.475145406449456 2.0 0.049180884661589 0.865711176141888 0.0102022057845348 0.964958184684855 0.0593830904461238 0.80329862352209 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAAF4 0.391519397612536 0.284427054043679 0.674251304622347 0.473723821155443 0.194924875399554 0.571343735852293 True False False False False False False 0 insufficient_or_context_specific +WDR60 0.179075435156832 0.28458501120212 0.67429276217953 -0.0959136435615927 0.546324418865238 0.81552807024429 -0.176203118826411 0.726514481255491 -0.208652839624744 0.581731121328947 -0.384855958451155 0.353194755449807 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMARCAD1 0.209854532470604 0.284869248374627 0.674513014896952 0.326496601501405 0.0911675098568321 0.472234212482528 -0.151513927861637 0.559520649104807 -0.300715061648055 0.155824442542143 -0.452228989509691 0.0549533665136731 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM8B 0.296667969889057 0.28494323983685 0.674513014896952 0.206349777162752 0.455146153088491 0.76641675985778 -0.332354807662611 0.676543281974651 -0.0522450829383935 0.939521030949247 -0.384599890601004 0.573721200175838 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF573 -0.194998446021339 0.285028128668083 0.674513014896952 -0.0293993242995258 0.872956330177627 0.959263070839262 False False False False False False False 0 insufficient_or_context_specific +PKD1 -0.193541396510266 0.285101548438887 0.674513014896952 -0.317812668967622 0.0633781577589287 0.432999502601999 0.162672944721946 0.739370149529914 -0.64112164706474 0.0909218964451135 -0.478448702342794 0.230997865610356 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC130 -0.242225323727628 0.285154343415253 0.674513014896952 -0.412953653378353 0.0632175043439271 0.432999502601999 0.441343649028523 1.0 0.240502550154865 0.573821296464724 -0.978586061408111 0.0139951898468372 -0.738083511253246 0.0657745545672101 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPS25 0.280715021865051 0.285174353886329 0.674513014896952 0.125992273494488 0.622644297392403 0.855079408706246 True False False False False False False 0 insufficient_or_context_specific +GLIPR2 0.309716396390445 0.285189060286038 0.674513014896952 -0.0962085863893273 0.762634270664709 0.916654443269353 0.691184515670628 0.263047164418451 2.0 -0.297922908029289 0.52206945977619 -0.052714828960382 0.904212286747937 -0.350637736989671 0.385415807774682 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GGCX -0.308338423727206 0.285271255389006 0.674556307815705 -0.441158778925883 0.113481872687923 0.4924007041452 -0.381873894956719 0.185091270678526 0.0051002123024076 0.987218315295993 -0.376773682654312 0.158856203853305 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EEPD1 -0.267008979721653 0.285354494031308 0.674576220002285 -0.281687907159207 0.260350394556069 0.623061542799626 0.58710525566401 1.0 0.176737061279408 0.688738071913646 0.136994716210581 0.688426611648138 0.313731777489989 0.383958468595042 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAF1 0.148801779574191 0.285407461143229 0.674576220002285 0.198678440071634 0.149817557968583 0.533583468169136 0.524824488000985 0.0909988556519471 0.121760416493427 3.0 -0.195494618772678 0.465060658282007 -0.0617660435629195 0.797498687789615 -0.257260662335598 0.273219007933399 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC011603.2 0.32639241408534 0.285716758211855 0.675005042112499 0.32990477906406 0.281401369406756 0.64315368591277 True False False False False False False 0 insufficient_or_context_specific +PPFIBP2 -0.325171885137451 0.28585371193492 0.675157107146631 -0.155046636408256 0.616223092756505 0.851916120639411 0.6759691365301309 1.0 -0.251429135087805 0.445384512827235 -0.458124852744315 0.106104090122557 -0.70955398783212 0.0295174356834403 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LAS1L -0.28199857582602 0.285909019326822 0.675157107146631 -0.451332418272243 0.0789710791436126 0.458237364234745 -0.0273570554806056 0.936257534403958 0.247833935657981 0.264500056193927 0.220476880177375 0.363758498193259 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLBP -0.296136845890792 0.286189515226141 0.675503350359926 -0.445678203480711 0.0946802740005036 0.474551164587418 0.357673237894673 1.0 0.0988940224098647 0.760199212498687 -0.559728365114998 0.0336620805336959 -0.460834342705133 0.0856094410366032 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTN -0.565902891190056 0.28630628163953 0.675503350359926 -0.476922627204206 0.371742858134155 0.710253546178141 0.570505528271455 0.6100872469635511 2.0 False False False False False False False 0 insufficient_or_context_specific +PLA2G16 0.414406187815915 0.286358669475853 0.675503350359926 0.439225768435722 0.259350300683268 0.622885940784012 0.0807642762106949 1.0 True False False False False False False 0 insufficient_or_context_specific +SMIM19 0.306251037964161 0.286519930868454 0.675692970763712 -0.111483786178169 0.703228765962857 0.891640364000942 0.15425358274349 0.680138276447243 0.279324043572521 0.298131220701374 0.433577626316011 0.153703630882635 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DLGAP4-AS1 0.253758084901844 0.286605194361909 0.675743108993533 -0.0873767395623452 0.717942207909501 0.898496799968868 False False False False False False False 0 insufficient_or_context_specific +SLC2A3 0.591415483683707 0.286758488822351 0.675953588967713 0.394785798559195 0.482711949077557 0.780666906162311 0.437242487691121 0.0804765727762992 2.0 -0.0599607817484875 0.949213952797514 -0.67193840221383 0.274066984064473 -0.731899183962318 0.308490847904493 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WASHC1 -0.244685638483527 0.287055741714789 0.676113727797714 -0.502912347334359 0.020679954543122 0.333389311130767 -0.119060511274685 0.635748446584602 -0.521466528915025 0.0204228386915211 -0.64052704018971 0.012540209536432 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP2S1 -0.255792568318739 0.287104258573702 0.676113727797714 -0.474290617798082 0.0423742050122018 0.3908928278867 0.527213146126526 1.0 0.421765612471673 0.168352366050657 -0.134250351245733 0.622138517342766 0.28751526122594 0.310100188256524 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBALD1 0.453625686140733 0.287142189557841 0.676113727797714 0.345596412559303 0.420047911140427 0.741990190194073 0.464161619427979 1.0 -0.15901761640735 0.5934438481956 0.120264355610383 0.620628033567446 -0.0387532607969677 0.895311082948626 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ADAMTS9-AS1 -0.542299687828505 0.287274690556975 0.676113727797714 -0.810917479620763 0.0981307249887743 0.478125555523304 0.236722244208498 1.0 False False False False False False False 0 insufficient_or_context_specific +C1ORF174 -0.509092022022083 0.287504582502331 0.676260601234414 -0.139078434626856 0.785245409691509 0.925705787798454 False False False False False False False 0 insufficient_or_context_specific +AC093334.1 0.394815689884959 0.287518953416815 0.676260601234414 0.025127016542954 0.946195577441739 0.985432868134933 True False False False False False False 0 insufficient_or_context_specific +ADD3 0.357199278298094 0.287870264455743 0.676380757851912 0.361393560947008 0.282407451107086 0.643569581003369 -0.103441789613055 0.755658401102719 0.312840816118036 0.202439237479238 0.209399026504981 0.424098343255221 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF525 -0.424477557927878 0.287879254336947 0.676380757851912 -0.451825489656894 0.254870100720443 0.619879203544451 False False False False False False False 0 insufficient_or_context_specific +MSI2 -0.190623166619438 0.28797454352158 0.676380757851912 -0.259548608647756 0.138270171880493 0.523810858054217 2.31569049797485 1.0 -0.421972291074793 0.216986480639805 -0.32277019574531 0.284791112532863 -0.744742486820103 0.0321406638843243 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01558 -0.689131438841825 0.288062093561454 0.676380757851912 -1.01643810988947 0.109204380507646 0.485176912870447 False False False False False False False 0 insufficient_or_context_specific +CPNE3 0.220311883137625 0.288151078769622 0.676380757851912 0.0400045173505551 0.843560200273101 0.9506514118099 -0.0738033129841856 0.885312885080925 0.265019694678747 0.438937154955535 0.191216381694561 0.62303817060341 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CC2D1B -0.246201409473399 0.28815253167176 0.676380757851912 -0.356590066102085 0.117411649124198 0.497239639401058 0.002872112408757 0.995590412151967 -0.899182845004707 0.0138796090199444 -0.89631073259595 0.0222580071520408 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIM1 -0.468708995517099 0.288154651307188 0.676380757851912 -0.452906842528298 0.306638160105232 0.661696690217148 0.7574456008727231 0.331658130572262 2.0 -0.347995232709765 0.352304564489166 0.0189236873937026 0.959522727463866 -0.329071545316062 0.330736417743932 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF627 -0.296243971508285 0.288156909340585 0.676380757851912 -0.451643001390185 0.106184048103021 0.483261130274234 0.524773315456389 0.310908489811167 2.0 False False False False False False False 0 insufficient_or_context_specific +SLC25A37 -0.173823379304818 0.288221969694664 0.676383097585299 -0.066524246620219 0.685428688728419 0.883393078075518 0.0747872911727717 0.793780843539333 -0.407447345057991 0.0628352859722564 -0.332660053885219 0.140447596252289 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00843 0.190565945745666 0.288422531832699 0.676703353575475 0.328832003592109 0.057639321121939 0.424809475920108 True False False False False False False 0 insufficient_or_context_specific +ZNF793 0.372013374862715 0.288556183649659 0.67686651565721 0.154404103392426 0.659241512472218 0.871995977033535 True False False False False False False 0 insufficient_or_context_specific +NUBP1 -0.249435549223728 0.288859032432045 0.677426402580525 -0.501070405119584 0.0276698305152606 0.361656300887855 -0.207779478049333 0.485187924806945 -0.407462168427365 0.105967960575702 -0.615241646476697 0.0325025005152503 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGAP21 0.203844293871111 0.28906676647079 0.677530371102782 0.340098896439031 0.0726935892574428 0.449108979935905 0.10102755690983 1.0 -0.0648204392971143 0.857278928161787 -0.55234062078228 0.0420192962565403 -0.617161060079395 0.0350979056414144 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CHST7 0.783751020240023 0.289188922621204 0.677598012657494 -0.402463385607946 0.558855629918334 0.821668752065948 0.2724542296247831 1.0 0.153864435200572 0.859070568791721 -0.119194336316455 0.842833617448804 0.0346700988841168 0.964191832303003 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GIT2 -0.158971244832424 0.289315121592247 0.677696742613083 -0.123440302937202 0.416097480822343 0.737601948039338 0.254922122328419 0.300332674814797 -0.501328360901464 0.0306372455285069 -0.246406238573045 0.276011964523011 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA0100 -0.218814044377766 0.289359435091852 0.677696742613083 -0.122489551668347 0.555564503547433 0.820425458699318 0.226851104222676 1.0 False False False False False False False 0 insufficient_or_context_specific +SCAMP3 -0.258854245880595 0.289566396600197 0.677909714990002 -0.213125210275836 0.382988874931342 0.718606102990066 0.252800579765441 1.0 -0.0499045343915173 0.905758363556087 -0.0922264655123186 0.76085473765111 -0.142130999903836 0.659510875806027 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERCC2 -0.399393030538609 0.289578785243882 0.677909714990002 -0.604543081796974 0.0919078980264132 0.472460751419842 0.489568191000705 1.23653627281654 2.0 -0.099816378529283 0.816683438586623 -0.689912137942935 0.0394356939773603 -0.789728516472218 0.033540914967055 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SETD1B -0.344020537394651 0.289697751242209 0.678025645793583 -0.56451265962907 0.0724195733463888 0.449108979935905 -0.231915442006137 0.377213373784817 0.0294705318734477 0.910443758390551 -0.202444910132689 0.392670992040164 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IVNS1ABP -0.286939521984306 0.289787349273955 0.678025645793583 -0.0467874323158315 0.859972997205058 0.956914759994669 -0.117869640997368 0.76808359147042 0.159150207618657 0.60300545906392 0.0412805666212891 0.911503240681756 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC88C -0.592778762197023 0.289820964147228 0.678025645793583 -0.379984386765061 0.503644461875823 0.792507633896657 -0.726242037960103 0.328001147353056 -0.467965843940177 0.484876296668573 -1.19420788190028 0.0968759766082303 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRMU -0.217022250107253 0.289976598062895 0.678191500057146 -0.181377678642106 0.377809080751504 0.715214004833462 -0.140078843816101 0.809003268319995 -0.271663252029837 0.508250230906171 -0.411742095845938 0.358803420157559 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NECAB3 -0.369563073711107 0.290165555436703 0.678380853476685 -0.664617338900342 0.0473048284317963 0.401231297569097 False False False False False False False 0 insufficient_or_context_specific +DDX27 -0.320530474679968 0.290267627705598 0.67846925244979 -0.288713061856237 0.343133692878491 0.689926781453268 -0.141708844527365 0.586604228967893 -0.231976367145482 0.264656586520684 -0.373685211672846 0.10017777987315 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TP53BP1 -0.195372945815281 0.290382268655397 0.678578043038158 -0.0228488769684274 0.900768498189105 0.968069401860807 False False False False False False False 0 insufficient_or_context_specific +PWAR6 0.277896104688368 0.290500566446609 0.678578043038158 0.240726919863396 0.36093118447821 0.703177809506737 True False False False False False False 0 insufficient_or_context_specific +AL117190.2 0.5805660546304 0.290642239729848 0.678578043038158 0.0937627017040662 0.858633887075302 0.956914759994669 True False False False False False False 0 insufficient_or_context_specific +CCDC85A 0.817825572801125 0.290735756153543 0.678578043038158 0.627040877623286 0.41450604934402 0.736663818217135 -1.52234769597723 0.103738815135727 0.159572927743206 0.874195794522036 -1.36277476823403 0.113127485709403 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COPE -0.364875283450966 0.290810183139108 0.678578043038158 0.0813800336254427 0.811342770946196 0.933742857603002 0.524145811433356 1.0 -0.199017075963758 0.463381410167706 0.309793814174842 0.173917578139571 0.110776738211084 0.662763506537615 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VASP -0.360403466611838 0.290922480522948 0.678578043038158 -0.727148985894142 0.0313808191034373 0.375031405408838 0.5909124221664871 1.0 0.351391003085552 0.355707331613491 -0.495869213251972 0.133485608619625 -0.144478210166421 0.697917409096274 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FSIP1 0.507358785633965 0.29098221567943 0.678578043038158 0.139215728813586 0.777160184412865 0.922929913000972 0.256609232280974 0.464716777484942 2.0 True False False False False False False 0 insufficient_or_context_specific +TOP3B 0.334649516639599 0.291006534714265 0.678578043038158 0.082329608289523 0.793903187317616 0.928063228447907 -0.186963651561438 0.553409182338267 -0.433855895996351 0.099916926550323 -0.620819547557789 0.0355956608625232 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C1QTNF6 -0.534399980805819 0.291023041091535 0.678578043038158 -0.505826977775599 0.319998911644685 0.672316094269812 1.26098086320668 0.0055830573429901 -1.08265545496012 0.0071686189819026 0.178325408246562 0.664668967986533 reversed False False False False False False False 0 insufficient_or_context_specific +GTPBP8 -0.297985731938945 0.291305124234496 0.678578043038158 -0.292583086173893 0.30081699238894 0.658632920234719 0.0702648872248353 0.848726472302442 -0.330170841792897 0.196151448503904 -0.259905954568062 0.345096409473757 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC011997.1 -0.416835482160037 0.291341733472965 0.678578043038158 -0.122868111527476 0.761479272243783 0.916100519182983 False False False False False False False 0 insufficient_or_context_specific +TPP1 -0.322385820247841 0.291380998319924 0.678578043038158 -0.330608299151997 0.279485296633109 0.642114507827558 0.1077670376802 0.731556142006226 0.246145395394474 0.301180809029653 0.353912433074674 0.163178788883901 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC009975.1 0.771716094897734 0.291499681883317 0.678578043038158 1.22564210029541 0.0986370877294262 0.478125555523304 0.179017235243894 1.0 True False False False False False False 0 insufficient_or_context_specific +RNF19A 0.268807983480988 0.291565601374204 0.678578043038158 -0.153967154656183 0.580363676172243 0.832538001769911 0.0903609039034711 0.743110500122104 -0.35947924361995 0.090895684373263 -0.269118339716478 0.224146101070646 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATF4 -0.21981405679206 0.291683292232067 0.678578043038158 -0.294922302474865 0.155358309533484 0.539558215777 0.497421595036125 0.317498722072589 2.0 -0.0783392397597759 0.858677756469417 0.0314115648314783 0.929102940637648 -0.0469276749282977 0.901259023930537 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC078923.1 -0.425546563686693 0.291897104165863 0.678578043038158 -0.455917969907327 0.258271088722835 0.622136927842961 False False False False False False False 0 insufficient_or_context_specific +RAPGEF4 0.350025057061085 0.292154977118237 0.678578043038158 0.330868176622833 0.320956529038239 0.672472248121257 -1.10073311549714 0.119425291315382 0.859365998373266 0.169904376486525 -0.241367117123878 0.7296531232897 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CATSPERB 0.453579382435172 0.292401875980892 0.678578043038158 -0.349828024440226 0.394741595117819 0.726080478554543 False False False False False False False 0 insufficient_or_context_specific +KBTBD3 0.445829468806575 0.292413664223246 0.678578043038158 0.275668462158357 0.506379350121871 0.793608039538775 True False False False False False False 0 insufficient_or_context_specific +ANKUB1 0.313944216690682 0.2924628859254 0.678578043038158 0.246710558483189 0.409318086482518 0.734857324041122 0.0397535258489992 1.0 True False False False False False False 0 insufficient_or_context_specific +EPN1 -0.293447640079639 0.292548951831979 0.678578043038158 -0.536165298885615 0.0413609704861098 0.389553190358918 0.915076954541424 1.0 -0.212131514268181 0.583492440470172 -0.0001003211647059 0.999728947121866 -0.212231835432887 0.531325937838118 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZCRB1 0.280784063519017 0.292579348506359 0.678578043038158 -0.11247898704801 0.669256577142426 0.876101666520689 0.0377250359140402 0.918658847405116 -0.249630796455879 0.308617298799051 -0.211905760541839 0.427455556149829 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCB10 0.215515809005248 0.292619981979627 0.678578043038158 0.276043628267836 0.174144274090459 0.555976790398267 -0.43665999614849 0.160798809911724 0.330670069045708 0.209598227135749 -0.105989927102782 0.731195778928087 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RAPGEFL1 -0.438937309906839 0.292654075644706 0.678578043038158 -0.404821272866138 0.334720698258222 0.684349560846303 False False False False False False False 0 insufficient_or_context_specific +AL596220.1 0.391294563806202 0.292781749108984 0.678578043038158 0.269948272502059 0.469982036688931 0.774115985605889 True False False False False False False 0 insufficient_or_context_specific +ENGASE -0.319366294616125 0.292802843446973 0.678578043038158 -0.491018265433276 0.100781720562266 0.478335084675213 0.848725068684546 0.12717527440867 -0.584712141356494 0.180310581395572 0.264012927328052 0.643190794046995 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP5ME 0.442282154173032 0.292913934501385 0.678578043038158 0.823333342439896 0.0520871715866733 0.413175325027871 0.400824840884934 1.0 True False False False False False False 0 insufficient_or_context_specific +ABR -0.168955479430651 0.292959337376345 0.678578043038158 -0.257885028718446 0.0983552145014421 0.478125555523304 0.5368307797694251 1.0 0.617222203252466 0.151884868967946 -0.38184079898352 0.280036312447677 0.235381404268946 0.575766719737267 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLCB3 -0.375416343252942 0.293013572476886 0.678578043038158 -0.203608253229337 0.576165349142631 0.829928048970172 0.23011818421474 0.416984035146931 -0.645842765923912 0.0175973677114717 -0.415724581709172 0.109877109311138 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NBPF11 0.20681020845721 0.293370016607483 0.679254525294256 0.144154503448552 0.466847226541692 0.77171958945157 True False False False False False False 0 insufficient_or_context_specific +DERL2 -0.303158379513167 0.293631222771023 0.679561256031666 0.0819334730467736 0.786353915890886 0.926121604088118 0.0139277481111629 1.0 -0.103312572858337 0.767545829781451 0.245097128920903 0.346043262447486 0.141784556062565 0.62406863118711 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF2AK1 0.197146510042268 0.293834385652103 0.679739583948951 0.0940600073069592 0.622074384599037 0.854851430443277 0.532031502210836 1.0 -0.384623423186126 0.289887087041712 0.499412446288876 0.109712092150086 0.11478902310275 0.747504020879527 partial_or_other True False False False False False False 0 cross_species_direction_conflict +OR6J1 0.741459696282439 0.293837039320233 0.679739583948951 0.21267926254656 0.743619453360061 0.909374800884141 True False False False False False False 0 insufficient_or_context_specific +ZNF335 -0.290722435783879 0.294165571480821 0.67978920301467 -0.419274279529653 0.126529990970811 0.508384607335028 0.5794470137983921 1.0 False False False False False False False 0 insufficient_or_context_specific +APH1B 0.311932421826224 0.294195472491884 0.67978920301467 0.0362525250773269 0.897783637322393 0.967796120806635 0.5112065714831511 1.0 True False False False False False False 0 insufficient_or_context_specific +GATA3 -0.490633926831169 0.294203441261343 0.67978920301467 -0.498819686875292 0.285875124997995 0.646864459864731 False False False False False False False 0 insufficient_or_context_specific +TRPM3 -0.348249351057206 0.294212913638336 0.67978920301467 -0.621939822326004 0.0544332583332623 0.419107768280135 False False False False False False False 0 insufficient_or_context_specific +CCS -0.279836182410206 0.294295032083686 0.67978920301467 -0.456637294925708 0.0749605241663469 0.452862231765951 0.0573514863180453 1.0 -0.837009971402008 0.0473983007582211 0.799451001979791 0.0404778094081923 -0.0375589694222172 0.931785027561273 reversed False False False False False False False 0 insufficient_or_context_specific +ESRRA -0.420697922717103 0.294319254358365 0.67978920301467 -0.517604183504778 0.195196607073681 0.571500015361699 0.372474413432797 1.0 -0.0948173531405407 0.813721649956029 -0.633628360971192 0.0437141795925583 -0.728445714111733 0.0319000867217699 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IFRD2 -0.508156879068946 0.294475852684902 0.67978920301467 -0.368023818878905 0.458428590180248 0.768146176023338 -0.451932252966914 0.222112009842322 -0.152495002324047 0.655036528161175 -0.604427255290961 0.0869800467584382 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C20ORF96 -0.419892108874835 0.29450075354796 0.67978920301467 -0.0417617920250005 0.922618031095202 0.977717672619005 0.28556778726043 1.0 False False False False False False False 0 insufficient_or_context_specific +GCH1 -0.417218467854342 0.294513584233621 0.67978920301467 -0.486218234305375 0.221698344586573 0.592957341103408 -0.987591710164601 0.0200119905822091 1.23407688728682 0.0055040065855936 0.246485177122222 0.505749509120609 reversed False False False False False False False 0 insufficient_or_context_specific +NRAS 0.353386251141254 0.294566736483436 0.67978920301467 -0.0429703373411255 0.904169804021594 0.969786702544198 0.321954018057437 0.340202438205098 -0.578543887851474 0.0550081036897018 -0.256589869794037 0.411644496434836 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL445426.1 0.351848393540571 0.294721944572219 0.679998752358717 -0.0304266210183803 0.924300474765689 0.978224179287905 False False False False False False False 0 insufficient_or_context_specific +TADA1 -0.399896850100221 0.294966500219108 0.680360093905034 -0.640826360388614 0.079566498002386 0.459160525051927 -0.23556535780336 0.579312487844748 0.283828960779472 0.388726195136093 0.0482636029761124 0.90880872725031 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01828 -0.837800817449679 0.295007436057704 0.680360093905034 -1.0746792402696 0.16378779181559 0.544850245278 False False False False False False False 0 insufficient_or_context_specific +FAXDC2 0.486170313853801 0.295133852277569 0.680467649203794 0.245931349216001 0.598496093493381 0.842680747516785 0.154390870715276 1.0 True False False False False False False 0 insufficient_or_context_specific +KANTR 0.182028431549957 0.295267275195883 0.680467649203794 0.0631774562301987 0.718239347219674 0.898496799968868 1.21292570746787 1.0 True False False False False False False 0 insufficient_or_context_specific +TXNDC12 -0.216888335239987 0.295268132734756 0.680467649203794 -0.281418847195688 0.162946844213 0.544298760692042 -0.124101772539113 0.680003820626813 0.355165708970002 0.123068007966237 0.231063936430889 0.342728802215553 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HHIPL1 -0.395576400673036 0.295439846967778 0.680467649203794 -0.189309107750694 0.617457820032138 0.85250682148546 0.4143506981772879 1.0 0.630400022366157 0.133887601967386 -0.0640314955161863 0.869602640484976 0.566368526849971 0.149084972466462 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABLIM1 -0.47061112110259 0.29544077514209 0.680467649203794 -0.65311427995815 0.143750021299047 0.53048330124968 0.230573969107311 0.783319090428104 2.0 -0.328900633135406 0.421374059314971 0.260543662324542 0.439538862002694 -0.0683569708108634 0.869967037789828 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GOLGA8A 0.383123384350094 0.29552456189628 0.680477733869798 0.312174492827283 0.396539037810983 0.727482043650453 0.113353632476312 1.0 True False False False False False False 0 insufficient_or_context_specific +PMS2 -0.23864704946715 0.295574056405275 0.680477733869798 -0.358320236271156 0.112680967203654 0.492069628801044 0.430389986398705 0.439274743255759 -0.354870252760239 0.393864955388464 0.0755197336384652 0.899150921009717 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BCR -0.233364037816568 0.295686423897241 0.680588023437338 -0.296263568400387 0.180355565542005 0.563389287311165 -0.297981675392078 0.325940113374392 0.263564291556898 0.311896044417269 -0.0344173838351795 0.915851876428785 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ENOSF1 -0.209022690447389 0.295913800016516 0.680962925146987 -0.403566868220716 0.0264939722893785 0.354528972663191 0.07646256080368599 1.0 False False False False False False False 0 insufficient_or_context_specific +TCF3 -0.269654707927725 0.296100659334374 0.681210777435147 -0.24584938421969 0.341834906841964 0.689130402583821 0.30870456302664 1.0 -0.236393681887034 0.41898617377148 -0.690688829047829 0.0160287499754662 -0.927082510934864 0.0068984836814744 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A12 0.325626200692335 0.296249746788036 0.681210777435147 0.268680614898535 0.390455023871708 0.722218665388488 -0.0716918179053568 0.831245542151547 -0.330921974280714 0.165220725046229 -0.40261379218607 0.119274412304978 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PEX13 0.234620834553275 0.29627803202587 0.681210777435147 0.170658980088017 0.444232986478514 0.759994423711047 0.0139105579188435 1.0 -0.0699844273076926 0.837892906728401 0.205006307774161 0.383384489490371 0.135021880466468 0.610519401148144 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC010997.3 0.490967216002418 0.296279587988463 0.681210777435147 0.20459862752833 0.652447530210161 0.870374832458737 True False False False False False False 0 insufficient_or_context_specific +MYO1C -0.234892799812538 0.296668241551346 0.681780442725444 -0.201764968450669 0.370499798815146 0.709933692593666 0.7686669913327271 1.0 0.0636397681440784 0.861736852686411 -0.0035796186850389 0.990997113713758 0.0600601494590395 0.844313095582903 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBCK1 -0.296683517974611 0.296716756899911 0.681780442725444 -0.308546024240224 0.277784416234551 0.641126042022682 0.33155509025537 1.0 -0.084950834885101 0.753444349195425 -0.34888271782403 0.0942712251808324 -0.433833552709131 0.0556752012051446 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAPN7 0.158578977720405 0.29680655066244 0.681780442725444 -0.008837976488135 0.953209915291436 0.987149466215884 0.630774611722291 0.0487660996930253 -0.211584899658878 0.411368029427231 0.419189712063414 0.152203443151801 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NAALADL2 0.226549816139284 0.296876051336123 0.681780442725444 0.391137137748423 0.0620545244750018 0.431813959784778 0.162208749955977 0.146018451012239 2.0 -0.392256992472394 0.534044309861936 -0.228745688464696 0.66454316692564 -0.62100268093709 0.261068935427344 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PAAF1 0.225864047747205 0.296914801633983 0.681780442725444 0.187997130274658 0.386270153455854 0.720477739899883 True False False False False False False 0 insufficient_or_context_specific +LINC00470 0.813176725515694 0.297213043635848 0.682022653192644 0.440525565848732 0.566241801624905 0.824113119711934 True False False False False False False 0 insufficient_or_context_specific +MCCC1 0.188508916753867 0.297218858233472 0.682022653192644 0.0347603990079617 0.848526620751296 0.953127856970211 0.05314030877871 0.0697625985748826 2.0 -0.522574700605802 0.154928620956831 0.790837397966197 0.0235909111603516 0.268262697360396 0.420486453492132 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GRIK1 0.529020712758754 0.297224823831989 0.682022653192644 0.391810655024419 0.43954878162991 0.756439451743861 True False False False False False False 0 insufficient_or_context_specific +NEU4 -0.876583487656188 0.29727867493773 0.682022653192644 -0.81570003120553 0.338192364344438 0.686264651691058 0.6906719398765239 1.0 False False False False False False False 0 insufficient_or_context_specific +EP400 -0.158326782266708 0.297453355954213 0.682275153631237 -0.218820499598611 0.142375197610953 0.528011532230573 -0.150381933904374 0.583503087281825 0.137237469498988 0.536084145510531 -0.0131444644053869 0.962037962938553 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SH3GLB2 -0.372809422284503 0.297975208998983 0.683099082571166 -0.457710714285889 0.195431371073574 0.571500015361699 0.17105790240515 0.36562009465151 2.0 -0.500811022915591 0.175099670205399 -0.176307426806728 0.598962055218587 -0.67711844972232 0.0600208372052234 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM106B 0.247429510330124 0.298006665497518 0.683099082571166 0.0350898003509314 0.883447743540488 0.96288234502947 -0.12645025878409 0.753360560689306 0.516141378006287 0.0946434125532968 0.389691119222197 0.218827484236105 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C8G -0.489400946218531 0.298118854316254 0.683194690820398 -0.427833074649621 0.365842435494602 0.707429383507695 -1.43602465733162 0.0064369020761184 1.66616211701243 0.0031379658270189 0.230137459680814 0.600107432608579 reversed False False False False False False False 0 insufficient_or_context_specific +RNF125 -0.672175705065302 0.298177792697518 0.683194690820398 -0.900550993991105 0.149916685576422 0.533583468169136 -1.73375906569098 0.0170520205894316 1.16498236988434 0.0619093351571781 -0.568776695806637 0.340135541384097 reversed False False False False False False False 0 insufficient_or_context_specific +U2AF2 0.215582344600211 0.298317793443017 0.683240215438019 0.0933341536745594 0.65362921984999 0.870639750062571 0.396247718752879 1.0 -0.0480792988625663 0.888246105077982 -0.483534582232392 0.0553091187388057 -0.531613881094958 0.0462112520750393 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MIEF1 0.339997724555069 0.298327087816752 0.683240215438019 0.230710802728372 0.482246279194172 0.780666906162311 0.482247098771185 0.013652067431403 2.0 -0.231458931165004 0.532838321757823 0.246180609027197 0.403679171002468 0.0147216778621926 0.969585471564195 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL031316.1 0.488788598860602 0.298572729829818 0.683654496105665 0.703287419730874 0.132706909272817 0.518983148534855 True False False False False False False 0 insufficient_or_context_specific +CLTCL1 0.253348222380219 0.298946561390509 0.68384785162735 0.202828125025397 0.403674582775995 0.732301760300508 0.417929431236828 1.0 True False False False False False False 0 insufficient_or_context_specific +XDH -0.709687634527386 0.298973508220876 0.68384785162735 -0.49636242007061 0.471790932197525 0.775037912267227 -0.649340107377474 0.107189088601133 0.570286701637565 0.113916446776431 -0.0790534057399093 0.850958362384589 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF248 0.189173897331285 0.298981027004342 0.68384785162735 0.29394617645965 0.107023349344893 0.483261130274234 0.0722328650130556 0.0591225382620026 2.0 True False False False False False False 0 insufficient_or_context_specific +ZNF667-AS1 0.313720516299368 0.299222293670399 0.684237983271032 0.38858880817805 0.200286118882021 0.575556382365159 0.8533578965418309 1.0 True False False False False False False 0 insufficient_or_context_specific +AKAP7 0.201101166794024 0.299297567070302 0.684237983271032 -0.0721492622240759 0.722998841809536 0.901761106410224 -0.203071266251318 0.488335954733525 -0.184199003832834 0.444111781246765 -0.387270270084152 0.136194608934765 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DARS2 -0.311713718997217 0.299456656280819 0.684342722297162 -0.0013646410379593 0.995491818710203 0.998795540446485 0.340200410458618 0.296836998207756 -0.217379387782242 0.414520184003729 0.122821022676376 0.70533188099601 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLT8D1 -0.275311500003768 0.299629047492727 0.684588505394549 -0.120339485249335 0.66026196386668 0.872407073022888 0.286579814787114 0.348376648842617 0.128767774940096 0.627442103374478 0.41534758972721 0.136244502957141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HIPK3 0.217109284926605 0.300035184090895 0.685016549665172 0.0725249126379065 0.735070008538838 0.905163185228954 0.560387155534745 1.0 -0.0176397640771604 0.955120450578508 0.346374528132768 0.1047863039189 0.328734764055607 0.142052474891757 partial_or_other True False False False False False False 0 cross_species_direction_conflict +VRK1 0.24859882728534 0.300062124004585 0.685016549665172 0.23710472735713 0.322180290780125 0.672877524535327 -0.0570638779412526 0.917089002819725 -0.326258304901925 0.35684902170341 -0.383322182843177 0.332646961763079 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PHF2 -0.173412829915433 0.300213363763061 0.685182164853091 -0.0720892912124298 0.676073781678231 0.879076687728825 0.709264572748604 1.0 -0.10005718537895 0.722474717926326 0.0225120164282355 0.929350818843529 -0.0775451689507142 0.757719280353454 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKRD54 -0.338191613692278 0.300450221244728 0.685574548498343 -0.259284898172149 0.432983985052587 0.751350456611089 0.563350285355398 0.381828938470635 2.0 -0.244727352697245 0.482629185563215 -0.36562399724817 0.204348735592352 -0.610351349945415 0.0608670023166825 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF133 0.206020890053612 0.300814565182356 0.685730686665997 0.218730254772253 0.271149423274465 0.635188731069848 True False False False False False False 0 insufficient_or_context_specific +LMTK2 0.136364464806724 0.300855159709079 0.685730686665997 0.168407963615104 0.19515162472563 0.571500015361699 0.762810149688379 1.0 -0.191802506890089 0.6987232884367 0.363392156156948 0.309931266350556 0.171589649266859 0.688030642577983 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRIM28 -0.289499310294663 0.300960816903458 0.685730686665997 -0.137452967295428 0.626945542782122 0.857199046968874 0.252815767251806 1.0 -0.0934961941709429 0.860104122968205 0.549329233737927 0.113947436229679 0.455833039566984 0.229310941714456 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MT-ND4 -0.237682079644188 0.300969928124687 0.685730686665997 -0.115163410744281 0.619027197354865 0.853557418006095 0.0499721786908305 1.0 -0.814597109845456 0.0627301623358899 1.07121198348238 0.0149966455263377 0.256614873636925 0.528660820207079 reversed False False False False False False False 0 insufficient_or_context_specific +KIAA1468 0.196419194749782 0.301003030809095 0.685730686665997 0.347750571692023 0.0601834320586352 0.429268745755419 True False False False False False False 0 insufficient_or_context_specific +EARS2 0.390419286554986 0.301023551345443 0.685730686665997 0.323689673441479 0.387969545229136 0.721539978602997 -0.0641584791380576 0.883206679897385 -0.483741934548696 0.111353765785177 -0.547900413686753 0.0975607026344402 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CHMP6 -0.319967783735534 0.301159901900792 0.685730686665997 -0.0324920878902249 0.918912622534177 0.975930957742715 0.0539779616197039 0.888246105077982 -0.469406591350369 0.0846418299169574 -0.415428629730665 0.147192067393116 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCBP3 0.335110660639828 0.301431495340696 0.685730686665997 0.448136988109336 0.164612895842698 0.544993086957416 0.149401369373006 0.425612241907736 0.122068496371178 3.0 -0.117374151541297 0.875755304740148 -0.747072759073296 0.155764121089429 -0.864446910614593 0.144790319988515 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RWDD1 0.314630095450245 0.301476197668216 0.685730686665997 0.210604319232495 0.486220512276242 0.782071323676502 -0.0030259320239347 0.995769508400761 0.203268930312222 0.550684402048604 0.200242998288288 0.605738557858624 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRTG 0.462245228847681 0.301538720366685 0.685730686665997 0.316694455637465 0.475667532065946 0.777735491146475 True False False False False False False 0 insufficient_or_context_specific +TIAM2 0.206901701973412 0.301555398810557 0.685730686665997 0.325720978548338 0.103475054365946 0.47958280245639 -0.589290674319979 0.613199845518292 0.496422638156446 0.564856283878203 -0.0928680361635336 0.931785027561273 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ETS2 0.275519421447946 0.301636760286885 0.685730686665997 -0.0381481584279404 0.885136675541515 0.963081098449005 1.57716359702366 1.0 0.0428561220797422 0.918029766464874 0.239186925253112 0.389289851679081 0.282043047332854 0.338138135987812 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF561 -0.273329983695126 0.301677398016235 0.685730686665997 -0.448432850574806 0.0788948304798695 0.458237364234745 False False False False False False False 0 insufficient_or_context_specific +CKAP5 -0.168426983964132 0.301707108355198 0.685730686665997 0.0103425057806385 0.950617532054686 0.986917609553614 0.547180496435054 0.12262778500787 -0.374257503458959 0.205240723211765 0.172922992976095 0.619316724447865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CFB -0.462581175135082 0.301717122631333 0.685730686665997 -0.390241464397437 0.384450431137794 0.719298323474503 -1.41457009271494 0.0056357354702492 0.985997955223877 0.0242235624773848 -0.428572137491058 0.290901368473032 reversed False False False False False False False 0 insufficient_or_context_specific +TMEM56-RWDD3 -0.466466383197026 0.30181762653314 0.685730686665997 -0.17129883025496 0.710854520114561 0.895074779173469 False False False False False False False 0 insufficient_or_context_specific +GPR157 -0.346694606009564 0.301990211845581 0.685827631031543 -0.520564009409281 0.108402143582754 0.485070295736365 0.510665253421524 0.263673391741742 -0.257289029041506 0.473231068164302 0.253376224380018 0.567815380494022 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RASSF2 -0.50308123729033 0.302706536160171 0.687011093890604 -0.646084837619755 0.179923466522318 0.562759923872656 -0.608314514003271 0.426048374862454 -0.728205430293841 0.279640266395101 -1.33651994429711 0.0743422716749945 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLG2 -0.241516258493354 0.302781541130142 0.687033636632717 0.0882231011452863 0.679719627983713 0.880961283783645 0.060990279584406 0.902588962655094 -0.767021284800039 0.0370071436187702 -0.706031005215633 0.0689563322752153 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SHARPIN 0.272187692232833 0.302873230397692 0.687094019453982 0.27977432364785 0.290000395142993 0.649379463821785 -0.0295659510738887 0.93439822035967 -0.20930507704651 0.375946299769004 -0.238871028120399 0.348262639042922 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AAED1 -0.376059369635128 0.303060667902245 0.687221852426223 -0.748234617542249 0.0254205514615649 0.351006805738558 False False False False False False False 0 insufficient_or_context_specific +ATP13A1 -0.342390556630776 0.303083965070839 0.687221852426223 -0.195205386161739 0.564008315462001 0.823754286312897 0.0760803531867102 0.798163481014814 -0.69630059793482 0.0087055705365661 -0.62022024474811 0.0201349712657595 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IQGAP2 -0.421952377723718 0.303124850042519 0.687221852426223 -0.599162997346278 0.1409489905524 0.526588620754509 -0.762006561816184 0.0376846241072105 1.08927517568066 0.0055442020339205 0.327268613864476 0.310100188256524 reversed False False False False False False False 0 insufficient_or_context_specific +ABCC9 -0.323410752328518 0.303685533334692 0.688197437421696 -0.415180008852877 0.181631004902021 0.564332404732057 -0.855529679057992 0.0171447546145492 0.916771572416953 0.009856579310474 0.0612418933589621 0.862329066522889 reversed False False False False False False False 0 insufficient_or_context_specific +ANKRD13C 0.174630444303394 0.303939365603979 0.688624854516482 0.19827068535258 0.241838780639412 0.608725035015447 -0.415628942541434 0.11053449046293 0.0011681221548865 0.996645110988921 -0.414460820386548 0.092360243179932 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RASD1 0.6516096197758 0.304011242237335 0.688639926097787 0.939088710660538 0.158690736126965 0.543060696740211 True False False False False False False 0 insufficient_or_context_specific +UBN1 -0.230027346464171 0.304182050823485 0.688684972588625 -0.352465340154273 0.104530963689893 0.480887980234376 0.160910026553917 0.542319186623861 -0.391640679747108 0.0781725678307495 -0.230730653193191 0.312109538426917 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CA2 -0.490814987815666 0.304289816573038 0.688684972588625 -0.427733620389322 0.373980208045477 0.712264906576428 False False False False False False False 0 insufficient_or_context_specific +SMAD4 0.215463259035992 0.304292043675501 0.688684972588625 0.214003764211411 0.30722326024609 0.661701213710167 -0.316531896616115 0.211917721893409 0.41358802558467 0.0678931609237665 0.0970561289685542 0.697307918331913 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DISC1 -0.273044302036478 0.3045386008137 0.689095273765762 -0.321110013509678 0.22656212864732 0.598909102217928 0.520867003188063 0.52341077466112 -1.45254831526667 0.0432307626495882 -0.931681312078605 0.249029672328158 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTRNR2L8 -0.642065144676819 0.305050623136888 0.689958114627092 -0.619860276493276 0.324403896991306 0.674622088720546 False False False False False False False 0 insufficient_or_context_specific +TFE3 -0.180378319109912 0.305125667361265 0.689980037695488 -0.223855664035283 0.199588588603721 0.575263953748573 0.294481807010559 1.0 -0.145806251189619 0.701769001297478 0.0924733996294381 0.764188416105607 -0.0533328515601809 0.882868463949616 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM48 -0.335628614801554 0.305313118255029 0.690203024649979 -0.236829185957703 0.478129177171164 0.778545319644225 0.212123144151227 0.512604506404501 -0.736699262327577 0.0148110747774802 -0.52457611817635 0.081092163729848 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CRY2 -0.305570201154657 0.305393476818487 0.690203024649979 -0.382091799245085 0.196829955003457 0.571879675616801 0.7914891115539009 0.697505670585628 0.0289313188185926 3.0 -0.0658695383903649 0.861352113077705 -0.068033248989523 0.809857260007246 -0.133902787379888 0.653082341747968 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNHG18 -0.328968547437779 0.30568451107263 0.69036356027618 -0.411470087575106 0.193947678984534 0.571026100033103 0.297784339069963 1.0 False False False False False False False 0 insufficient_or_context_specific +LRAT -0.559254620868956 0.305790565768704 0.69036356027618 -1.01440228790077 0.0540695927953247 0.419081294430039 0.945987388500719 0.0426771445279066 -0.691750552917034 0.0910857986325187 0.254236835583685 0.558367411215417 reversed False False False False False False False 0 insufficient_or_context_specific +SFT2D2 0.231638230509399 0.305822198497058 0.69036356027618 0.191058298871949 0.39964735336335 0.729679668746226 -0.553848707540448 0.0920718000202411 0.913713773068231 0.0080477022420879 0.359865065527783 0.224078614748809 reversed True False False False False False False 0 cross_species_direction_conflict +RIPK1 -0.180404009249091 0.305937313837843 0.69036356027618 -0.205197864607961 0.241358885267108 0.608572375975566 0.273096632557926 1.0 -0.142891833405544 0.542643112857601 -0.0273942676671217 0.902496677517233 -0.170286101072666 0.400661741132724 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCN8A -0.599089610087869 0.305949147426809 0.69036356027618 -0.57951810138289 0.323527291555436 0.673691919126913 False False False False False False False 0 insufficient_or_context_specific +JAK3 -0.419773438021827 0.306046253883438 0.690435117201141 -0.280616630429923 0.497624578576047 0.789469616920496 0.858568740390564 0.135024404161285 -1.28681656161386 0.0216514796295463 -0.428247821223294 0.4372680606658 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDZRN3 0.344356227811467 0.306565287293324 0.691211779253462 -0.0605965454761751 0.858921765867771 0.956914759994669 0.733759478941198 1.0 1.02577385831001 0.003094160645123 -0.646920355930702 0.0198969181107023 0.378853502379311 0.163938240055891 reversed False False False False False False False 0 insufficient_or_context_specific +PXK 0.20833181438219 0.306652393826787 0.691211779253462 0.148977427108856 0.466191151222891 0.771256747133237 1.29649143126854 1.0 -0.289475704095033 0.315897059875411 -0.0569485993650723 0.836374371846694 -0.346424303460105 0.187663745335783 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TG 0.347867683396817 0.30694497673661 0.6912288995205 0.072155904968352 0.837260348259504 0.9475608057588 0.908006686753544 1.0 True False False False False False False 0 insufficient_or_context_specific +SMG7 -0.18849528848269 0.3069636074009 0.6912288995205 0.0727635770693457 0.702184289969384 0.8914937149467 0.0027184217970511 0.993768636619091 -0.0516315773683135 0.827240988011121 -0.0489131555712624 0.853338855715498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MDGA1 0.524073850014425 0.307041634467877 0.6912288995205 0.111121970268731 0.829264378082551 0.942947704141109 0.6750060255464271 0.669909196949531 2.0 True False False False False False False 0 insufficient_or_context_specific +KIAA1147 0.246505355531841 0.307093975027286 0.6912288995205 0.347306641948885 0.147505559574837 0.532796338690088 True False False False False False False 0 insufficient_or_context_specific +NCK1 0.174486085686292 0.307108207306609 0.6912288995205 0.33035633171475 0.0464681950328523 0.398741839274603 -0.223639711118916 0.414917466479094 0.0814406564809953 0.737052843848367 -0.14219905463792 0.574442723444002 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC005237.1 0.335661158885744 0.307118276913304 0.6912288995205 0.590826811549238 0.0777806272935681 0.457223891665554 0.041078049391633 1.0 True False False False False False False 0 insufficient_or_context_specific +GATA6 0.347630014768207 0.307389083740921 0.691543564060653 -0.197184102657936 0.522109870947463 0.802392433400774 0.525881612279961 0.369826757158489 2.0 0.195224575786221 0.675926385250434 -0.0603058273304313 0.882992873403053 0.134918748455789 0.747478840305635 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SF3B4 -0.373418917926142 0.307816879197183 0.692116129900691 -0.124749012763804 0.747910203898527 0.910042172727976 0.341565280787569 1.0 0.0740597998942336 0.888468487049792 0.290811356585617 0.39298634491001 0.36487115647985 0.336025599851686 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KAT8 -0.229010275811837 0.30787404367294 0.692116129900691 -0.424730100725905 0.0488695467673221 0.404047580308211 0.206848900154418 1.0 0.0209740579730738 0.954530635502806 -0.267758511166469 0.269085160998496 -0.246784453193395 0.347888897701775 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HEXIM1 -0.390410239607413 0.307887784160455 0.692116129900691 -0.745029764933384 0.0427267699087019 0.391483132487066 0.365155832988973 0.3320820993661099 2.0 -0.373292723775775 0.181984582454551 0.719986459045342 0.0116873349950443 0.346693735269567 0.175922154109519 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPL33 0.265600035359363 0.307917881631192 0.692116129900691 0.357220245678149 0.172476083545348 0.553858965567902 True False False False False False False 0 insufficient_or_context_specific +KIAA1211 0.487099923156479 0.308139036964585 0.692345595290932 0.606026431870366 0.202658990365148 0.57668584531318 0.436710793054871 0.118468837749453 2.0 True False False False False False False 0 insufficient_or_context_specific +RSU1 0.277081319669922 0.308226097273506 0.692393858513548 -0.0431373113933125 0.880654024885666 0.96227446663699 0.650469591329109 1.0 0.13437885635965 0.684020812566494 0.0878464279059758 0.747179218785501 0.222225284265626 0.412359591001027 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIGLEC7 -0.547527435152832 0.308380154609909 0.692554584050891 -0.534706642033999 0.320724821069972 0.672472248121257 False False False False False False False 0 insufficient_or_context_specific +TGOLN2 -0.265059018002961 0.308478358825556 0.692554584050891 -0.37581650575357 0.13871472978515 0.523989308433494 False False False False False False False 0 insufficient_or_context_specific +LRRC29 0.360651568719386 0.308636143943791 0.692554584050891 0.0844138790814504 0.806756526924051 0.932788199072101 -1.09576515532212 0.07336470368257 0.516996852293499 0.325351398427047 -0.578768303028623 0.284010047383501 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC018467.1 -0.71959590839243 0.308663780388326 0.692554584050891 -0.866971444015984 0.215865245851162 0.587852789707652 False False False False False False False 0 insufficient_or_context_specific +PCF11 -0.150171606894425 0.308685607378178 0.692554584050891 -0.221938131718492 0.123643004800586 0.505390183772585 0.0213180353502258 0.95834264814358 -0.907728342536773 0.0087124079721892 -0.886410307186547 0.0137183103444898 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF675 -0.235544398420143 0.308763310495952 0.692554584050891 -0.183455768048505 0.431594841525101 0.750342447295744 False False False False False False False 0 insufficient_or_context_specific +DBI -0.305100567845197 0.308932265463674 0.692554584050891 -0.160095362139264 0.601371614661358 0.843982654206383 -0.58420244321651 0.102551265015928 0.978499112842533 0.0098077464507899 0.394296669626023 0.229210324044655 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RALGPS2 -0.257547851550749 0.309143583648795 0.692554584050891 -0.0297825635312891 0.904001200291865 0.969766782430554 0.403470954067135 1.0 -0.17319322722139 0.643226897816119 0.0332227055519496 0.920273026313064 -0.13997052166944 0.674940259467405 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LTBR -0.229607317988762 0.30927456322877 0.692554584050891 -0.0556536418079834 0.815736265185667 0.936230700610385 -0.0953868425301812 0.731556142006226 0.375375071046109 0.0853227920294281 0.279988228515928 0.209387006728913 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AGRN -0.284273017235773 0.309362830324538 0.692554584050891 -0.006612199463867 0.981916328907721 0.99451887511202 0.7904745904288148 0.826013324052756 2.0 0.266956724719973 0.323112906182978 -0.718577799777836 0.0101173495723083 -0.451621075057863 0.0787042290228642 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAPZA2 0.19630194339396 0.309541364707332 0.692554584050891 0.296209383195269 0.117581722832597 0.497239639401058 0.0732749441205575 1.0 -0.216247773366106 0.572485518177165 0.692333665239769 0.02901019042136 0.476085891873663 0.135275628399412 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EPHX1 -0.297454356806739 0.309657942521837 0.692554584050891 -0.139218103790783 0.634014566067455 0.861847932958146 0.4423914694083139 1.0 0.283471137326044 0.572198191260242 0.370576771249235 0.36559061399214 0.654047908575279 0.13030477652057 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB18 0.201385814613266 0.309675145984491 0.692554584050891 0.223599780396695 0.257897507203613 0.621906676979798 -0.356052374301697 0.210839299702864 0.409777865606502 0.106812032561854 0.0537254913048043 0.857258186158439 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MED28 0.204094663272507 0.309774288290742 0.692629592497598 0.32080578207665 0.12235950178489 0.5038394341269 -0.398901335283927 0.175099670205399 0.190072305431442 0.461522463567677 -0.208829029852485 0.443486496873771 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF395 0.389212488862255 0.309846120768075 0.69264351959969 0.28989753739795 0.447159362667403 0.761469121135878 0.259442002920588 1.0 True False False False False False False 0 insufficient_or_context_specific +C6ORF62 0.216375464871815 0.310060814024959 0.692846796036921 0.0661708910252327 0.755964315263784 0.914440101763119 True False False False False False False 0 insufficient_or_context_specific +TNFAIP8 -0.3137608531589 0.310068299988109 0.692846796036921 -0.614742337468567 0.0349245149171721 0.37720666979567 -0.613783211687525 0.0825452834283036 0.66771998771713 0.0390787895251511 0.0539367760296056 0.884017730364854 reversed False False False False False False False 0 insufficient_or_context_specific +AC004805.1 -0.299575591517934 0.310278946881972 0.693024142411649 -0.376048968523397 0.195409786343404 0.571500015361699 False False False False False False False 0 insufficient_or_context_specific +HNF4A -0.628181894117502 0.310442632321388 0.693240160019472 -0.739064979851177 0.230208234504001 0.601320766920643 -1.02394742538168 0.0574898507799 0.578535631748051 0.214496589529309 -0.445411793633628 0.357624107667394 reversed False False False False False False False 0 insufficient_or_context_specific +MREG -0.446881371366921 0.310506982073507 0.693240160019472 -0.606822394253969 0.167856981186471 0.547661930583053 -0.848655096339762 0.0955724765413923 0.775921362810919 0.0877219984008633 -0.0727337335288434 0.892828755240047 reversed False False False False False False False 0 insufficient_or_context_specific +LINC02015 0.635270330635751 0.310578230971912 0.693252634799459 0.38868876822179 0.529884339545159 0.807173403104572 0.28246121424602 1.27035264122186 2.0 True False False False False False False 0 insufficient_or_context_specific +ANKRD36 0.231440016250965 0.31069951927182 0.693321067905565 0.596723003321325 0.0070031729672938 0.282692791660547 0.119858631568116 0.111269865117966 2.0 True False False False False False False 0 insufficient_or_context_specific +HOMER2 -0.446929500227603 0.310775711645712 0.693321067905565 -0.556930285676223 0.202461861721089 0.57668584531318 -1.17531900397264 0.0589308290257713 0.496220769076123 0.35603275839058 -0.679098234896516 0.217637705424236 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AMDHD1 -0.640008075482778 0.310846394325311 0.693321067905565 -0.68195925154951 0.279267408661098 0.642114507827558 -1.39416779745197 0.0115325794310687 0.93962355085634 0.0470467636611634 -0.454544246595629 0.318852270527699 reversed False False False False False False False 0 insufficient_or_context_specific +RNF121 -0.21117359066861 0.311068563995895 0.693321067905565 0.0019643594121082 0.9926018851001 0.998236115892821 0.7528840433993571 0.293262565455904 2.0 -0.0190353921989391 0.963257176400296 -0.279548604137646 0.314801948763958 -0.298583996336585 0.321631686364294 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NT5DC3 -0.416629539827481 0.311151027696081 0.693358495233268 -0.179441798727012 0.664106140250241 0.874384483010807 -0.158316033302763 0.66186594305069 -0.32003073165444 0.250073122511645 -0.478346764957202 0.120165656424058 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MCOLN1 -0.385217276000859 0.311244998888306 0.69336913990631 -0.335562992165882 0.380399113346893 0.716671165026344 0.5448503661783071 1.0 -0.0089555749322743 0.978307561722072 -0.118124983592419 0.598616155839273 -0.127080558524693 0.602303973174657 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP4F11 -0.509161317707491 0.311287149380177 0.69336913990631 -0.695925006372906 0.161324831900194 0.543541307772207 False False False False False False False 0 insufficient_or_context_specific +AC083843.3 0.358724125987509 0.311443769494648 0.69344878959645 0.68290433805556 0.0522744792350064 0.41403897356579 True False False False False False False 0 insufficient_or_context_specific +ZSWIM6 -0.178267811002808 0.311709895702896 0.693580991012765 -0.151822010001416 0.389454364696658 0.722218665388488 0.704508962861245 1.0 0.210753748367001 0.619034057486679 0.127882204633015 0.702432699749086 0.338635953000016 0.338217335156642 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCT3 -0.192219047037048 0.311853356509275 0.693580991012765 -0.125951178096404 0.50016873828747 0.790819493321426 0.31533036538907 0.446538994114857 0.101613052624009 0.780273817796794 0.416943418013079 0.252500898993632 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLEC4G -0.827318878509409 0.312086743439792 0.693580991012765 -1.17701117682065 0.138491445917997 0.523810858054217 0.305281982051678 0.37376664566309 0.107971227667737 0.725525822333594 0.413253209719415 0.181510145398386 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RMDN1 0.146490543571858 0.312158543251275 0.693580991012765 0.0373176856044374 0.791455014221069 0.927588847807277 -0.064023466065198 0.843047533896762 -0.386513138824018 0.0952315236473516 -0.450536604889216 0.0737117685114303 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SEPHS2 -0.275490388431016 0.312274104664196 0.693580991012765 -0.227392769771241 0.412133045773983 0.735291083225579 -0.738415757839397 0.15820560140965 0.571797550069834 0.216543991742707 -0.166618207769562 0.751669464110695 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF891 0.225960072410096 0.312294537198342 0.693580991012765 0.137598749502749 0.539951097097061 0.812783927483158 True False False False False False False 0 insufficient_or_context_specific +URI1 0.173623852232282 0.312355105154459 0.693580991012765 0.2364077763016 0.16560841356611 0.545468009482397 0.70421043455951 1.0 -0.0918544298993261 0.787647587732967 0.0248912074097027 0.931351968334598 -0.0669632224896233 0.822691819724128 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC020915.3 0.281161837672762 0.312441298555571 0.693580991012765 0.0470493654382944 0.865241404188734 0.958391272020028 True False False False False False False 0 insufficient_or_context_specific +RCOR3 0.208134557082652 0.312479662172621 0.693580991012765 0.0268577470612859 0.891574738000321 0.965065212610968 -0.0488984366908643 0.910616206759683 -0.381800719136117 0.191579513057265 -0.430699155826981 0.172343938336757 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAP7 -0.372843816549925 0.312499031468812 0.693580991012765 -0.576306712808316 0.107106558518821 0.483261130274234 1.27264586969206 1.0 -0.752137284453909 0.126291368437372 0.0902562684780457 0.852471919208769 -0.661881015975864 0.146440268819089 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TSPAN4 -0.337078732936061 0.312661644407873 0.693650271413811 -0.409922279322176 0.216939099644553 0.588712555412956 0.21519991574959 1.0 0.361378451185453 0.268743912777657 -0.168124727447167 0.562115379051027 0.193253723738286 0.532746610330039 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIFR -0.458089084004411 0.31290936875648 0.694054015825823 -0.0626404775720323 0.891304930289439 0.964971026865863 -0.262114971469419 0.463381410167706 0.151354204799236 0.627543961393596 -0.110760766670183 0.7468338213257 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00862 -0.4214421492308 0.313154234017409 0.694305418470349 -0.500483393917137 0.228268879473851 0.60038155150582 1.04890021641512 1.0 False False False False False False False 0 insufficient_or_context_specific +SYT1 -0.698918164199817 0.313297250075654 0.694476667289261 -0.62089304569212 0.371145224760947 0.710081732756023 -1.94523101774905 0.0199171899096341 1.45513471776 0.0436718087936593 -0.490096299989044 0.430076234549366 reversed False False False False False False False 0 insufficient_or_context_specific +CCNL1 -0.2740907475804 0.313402389731818 0.694563902348559 -0.343676406251189 0.206755415814893 0.579793806155017 1.23644284338241 1.0 0.109312918082808 0.731556142006226 -0.353932218571128 0.15234692916305 -0.24461930048832 0.342704295804414 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BBS7 0.281205900003104 0.313579179943706 0.694630356489016 0.261064695524195 0.349356715846972 0.694288655897113 -0.130003954539619 0.840915112898908 -0.158519549595263 0.725525822333594 -0.288523504134882 0.569766877876537 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KIF5B 0.208511430190498 0.313604436422768 0.694630356489016 0.202265947993318 0.329143314844465 0.67793506011078 1.60570221883999 1.0 -0.019413975256404 0.95260960138231 -0.0758553596940081 0.746002714571707 -0.0952693349504121 0.704157063557181 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ADAMTS4 -0.807983387195136 0.313629750841366 0.694630356489016 -1.02492066094211 0.191825425680789 0.570665777497258 1.7269230445369 0.0139612537194478 -1.81581615137189 0.0060349363502649 -0.0888931068349845 0.911503240681756 reversed False False False False False False False 0 insufficient_or_context_specific +TIAM1 -0.302637932676246 0.313894983114205 0.695071986518409 -0.351044797190942 0.243945563390441 0.610315684654444 0.7511471696459849 1.0 -0.169451034013159 0.810391348201517 -0.27755641769476 0.586819437104433 -0.447007451707919 0.41562659654471 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DLAT -0.330421941227762 0.314063722239458 0.69518456354526 -0.446860470226701 0.165386778649412 0.545468009482397 -0.0967884872763877 0.775277079535413 0.214393457451171 0.380660815284112 0.117604970174783 0.678208049807557 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EYS 0.32285812109972 0.314230630170498 0.69518456354526 0.528021207557274 0.0912890725210115 0.472234212482528 0.0275086630330872 1.0 True False False False False False False 0 insufficient_or_context_specific +RND3 -0.239795433572039 0.314419904293548 0.69518456354526 -0.354217374422172 0.140241689227376 0.525724762599689 0.730759456616217 1.0 0.168388696329779 0.778604469489426 -0.198428724479443 0.671658317711473 -0.0300400281496633 0.956212493345361 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GRHPR -0.312669149191964 0.314469606460187 0.69518456354526 -0.324599875122499 0.296114684881623 0.653643914484669 -0.888212940265566 0.0077499526816097 1.08405060757823 0.0027593693237275 0.195837667312664 0.476015795629519 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF180 -0.283273732729286 0.314488123761702 0.69518456354526 -0.494621379377222 0.0637913113043933 0.432999502601999 False False False False False False False 0 insufficient_or_context_specific +PRRC2C -0.15571763409221 0.314550955960122 0.69518456354526 -0.202117730680556 0.181063556001131 0.563603217043398 0.0315064929380767 0.925502799508407 0.187076418076611 0.411609587958212 0.218582911014688 0.361586371787899 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LDHA 0.360021760783698 0.31466878678203 0.69518456354526 0.529393719207639 0.137700140452399 0.523810858054217 0.107015699048639 0.0170400251208574 2.0 -0.347374432373885 0.311813935604745 0.172031212039279 0.573943365505474 -0.175343220334606 0.590203395087349 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COLEC11 -0.276175863756494 0.314727583814455 0.69518456354526 -0.320428910225813 0.235869919618137 0.604926482992162 0.8644293260074369 1.0 -0.199689887521621 0.629416114107111 0.449511245529861 0.179392230670449 0.24982135800824 0.477609991195525 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DCTD -0.201006390782082 0.314857502871738 0.69518456354526 0.0925934183336657 0.628034480001978 0.858021226690073 False False False False False False False 0 insufficient_or_context_specific +NPIPA1 0.304888506917773 0.314882220367373 0.69518456354526 0.390743354030634 0.197868514608414 0.572749206617264 0.0519147283968981 1.0 True False False False False False False 0 insufficient_or_context_specific +ATXN7 -0.268523224835121 0.31493348810731 0.69518456354526 -0.122567636004883 0.65492282878621 0.871217143498979 1.29841323620075 1.0 -0.175873807507978 0.560983902319736 -0.472401118323573 0.0658843925485911 -0.648274925831551 0.0266127509879863 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FES -0.493085537633528 0.315202121462165 0.695486729027698 -0.528222793621543 0.280405798918194 0.642477283866194 0.5825246040250379 1.0 0.162220427023428 0.593000293897183 -0.9104287583848 0.0043475034150019 -0.748208331361372 0.0159316931008995 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITPR1 0.276006337769143 0.315475014633153 0.695928232015649 -0.0310990403609561 0.91377854183966 0.973857189638593 0.165188786795578 1.0 0.0096178307330952 0.979995535439195 -0.439556374307623 0.09442214223076 -0.429938543574527 0.115597349395428 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SON -0.162154236517722 0.315534044957275 0.695928232015649 -0.125824497694546 0.435917081626349 0.753451320678163 0.148771994418292 0.666929076268809 0.0624141404208117 0.836258170715015 0.211186134839104 0.462901842498847 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC1A3 0.756651174605527 0.315656790578829 0.696053549484393 0.521238858417065 0.485741976520305 0.782071323676502 True False False False False False False 0 insufficient_or_context_specific +TNFSF10 -0.48875113340646 0.315795739779861 0.696078007072372 -0.309766104550017 0.534430002348738 0.810822239516881 -1.08646360072705 0.0548730118937861 0.746198305199244 0.114755837452606 -0.340265295527808 0.48455125087627 reversed False False False False False False False 0 insufficient_or_context_specific +PTDSS1 -0.330204025577934 0.315862226879278 0.696078007072372 -0.118066995005119 0.727128528625101 0.903365569206837 0.292447541999795 1.0 -0.0248989535065355 0.950285004327358 0.300618169916369 0.253317124321996 0.275719216409834 0.328099077737327 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASTN1 -0.442175148523318 0.315865668865669 0.696078007072372 -0.953406728224564 0.0238372160383862 0.348898908348731 False False False False False False False 0 insufficient_or_context_specific +FAM76A -0.306938321469733 0.315978415847466 0.696181159123026 -0.554864575061816 0.0572887153961361 0.424455207563489 0.450510263478865 0.269188863500723 2.0 -0.149614321845959 0.695727847094886 0.078907204693978 0.80304293369629 -0.0707071171519808 0.842531613813403 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01482 -0.82267314056322 0.31657125283563 0.69698002878843 -0.913030684306075 0.265543058607936 0.62822323708046 False False False False False False False 0 insufficient_or_context_specific +EAPP 0.280805491750514 0.316712375832568 0.69698002878843 -0.0047730344925762 0.986462086013514 0.995776265418118 -0.411374604754758 0.0826621109573172 0.337803803635677 0.10654360470129 -0.0735708011190805 0.758118683472352 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HYKK 0.426993952973425 0.316740915655469 0.69698002878843 -0.0608129547684853 0.885971166832583 0.963332560016303 -0.608904257019568 0.142771785318865 0.930738316853896 0.0189588865261606 0.321834059834328 0.385415807774682 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TEK -0.5015041502804 0.316777954230641 0.69698002878843 -1.06407320734355 0.0253663429331106 0.351006805738558 0.124685370422169 0.777386064339247 -0.0114335562596355 0.974423910121543 0.113251814162533 0.767246368533858 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HINFP -0.217156155667484 0.316803102685705 0.69698002878843 -0.14130950541701 0.523575066550361 0.80370058056999 -0.175979599219352 0.656243729758364 -0.668248587672582 0.0452079057461777 -0.844228186891933 0.0261046383534997 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACTR1A -0.220164887401574 0.316912203917693 0.697074801867293 0.0723613929481844 0.764043893345669 0.917095887442426 0.224736777736056 1.0 0.210972169628193 0.49277238289556 0.159053031759524 0.533055124347752 0.370025201387717 0.168060970947063 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM218 -0.341120672649051 0.31707646602188 0.697122293063259 -0.297099691987721 0.382630805724772 0.718507811674046 0.441792758959536 0.455016029861853 -0.710681828293206 0.13316453709146 -0.268889069333669 0.644380117039548 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SVIP -0.403065842365505 0.317129983675197 0.697122293063259 -0.589011183243058 0.134354233397429 0.520900171021663 -0.718652002235663 0.327369814686324 0.99845536703159 0.0914100223101606 0.279803364795927 0.671408448395402 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SP2 -0.232488594504236 0.317131878535976 0.697122293063259 -0.371584883784573 0.0941235090930368 0.474102577239623 0.371518300223331 0.283267089054752 2.0 -0.0424655755459962 0.949213952797514 0.523847989462688 0.196385267215777 0.481382413916691 0.290298560814418 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CREB5 -0.432308564311321 0.317421327112037 0.69725537777819 0.158358859753545 0.71302185872949 0.895497343705388 False False False False False False False 0 insufficient_or_context_specific +GNAS-AS1 -0.263577531202367 0.317544293808672 0.69725537777819 -0.246755868174117 0.350582862518393 0.695446709826455 False False False False False False False 0 insufficient_or_context_specific +MOGAT2 -0.823534643232937 0.317604459927558 0.69725537777819 -0.920703037834391 0.259671637989059 0.622885940784012 False False False False False False False 0 insufficient_or_context_specific +MYO19 -0.228637944141417 0.317649884632593 0.69725537777819 0.0920797016371797 0.68407609194627 0.882766419515653 0.042568615556483 0.941986184105119 -1.02848428696925 0.0221653424445383 -0.985915671412772 0.0388977955560783 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIRT5 -0.345793309532383 0.317687514116138 0.69725537777819 -0.348480428628465 0.314250797577147 0.666772492126109 0.529081965144366 1.0 -0.421993763834077 0.203059248326729 0.119712805313066 0.689867120792113 -0.302280958521011 0.319795771820636 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL11 0.244248875221204 0.317805525706164 0.69725537777819 0.253890995676966 0.298948018409045 0.657023958480272 0.284774117440547 1.0 True False False False False False False 0 insufficient_or_context_specific +SYTL3 0.651826444451985 0.317823637707085 0.69725537777819 0.343433744125046 0.586829519145902 0.835274227991216 0.632988150149247 1.0 True False False False False False False 0 insufficient_or_context_specific +SLC9A8 -0.15380831431543 0.317823712617611 0.69725537777819 -0.134662568130172 0.378218096984833 0.715375612319217 0.9917734089156379 1.0 -0.316444164267482 0.183808522904091 -0.0595982911001794 0.790074451741229 -0.376042455367661 0.0954444695151388 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PARP2 -0.322183894962993 0.317936265237477 0.69725537777819 -0.410761366712443 0.193071022599494 0.570885363891703 0.38912496480164 0.326047081407242 -0.774217606901072 0.0349923604746569 -0.385092642099432 0.297325788507384 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPL19 0.272601088800453 0.318016330601478 0.69725537777819 0.339373813007547 0.215744192504831 0.587852789707652 0.268813577297269 1.0 True False False False False False False 0 insufficient_or_context_specific +XYLT1 0.527102872679551 0.318183602382254 0.69738567769171 -0.853889697337171 0.0842538210666169 0.464779732481256 0.850139085758702 0.803649457640569 0.215963452388304 3.0 1.0613425168775 0.150015127292629 -0.653410227688334 0.233417676516236 0.407932289189164 0.590034275997834 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1D 0.309974788928604 0.318477019848366 0.697472349633326 0.12040548157948 0.699088796643555 0.889654761580003 0.7339909103012789 1.0 -0.255653117590688 0.399031887407967 0.430250664274863 0.093970436715718 0.174597546684175 0.527332994705941 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ENTPD3-AS1 0.297828137872676 0.318542656000445 0.697472349633326 0.317027101111131 0.288301534128484 0.648310091921223 True False False False False False False 0 insufficient_or_context_specific +NAA25 -0.194509373160174 0.318549808118627 0.697472349633326 0.0453997720559273 0.809832403234719 0.933206109812517 0.9297916682855452 1.0 -0.137660043855909 0.758158147574253 0.0726583469431739 0.840136703082598 -0.0650016969127352 0.873803199758035 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RICTOR 0.173707261055621 0.318563912318889 0.697472349633326 0.243869306491041 0.152424295542995 0.53585913930413 -0.238675381805937 0.541589854378513 -0.179092983619215 0.58113785578188 -0.417768365425152 0.216768111508841 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AKAP12 -0.562839222104254 0.318677821449636 0.697472349633326 -0.858630152980563 0.1214619818797 0.503485437181972 0.4975199192401301 1.0 0.977555762628259 0.0631063745926361 -0.178497011461633 0.672240404962407 0.799058751166627 0.104106073041952 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC012409.2 0.342185487880302 0.318678406386737 0.697472349633326 0.163804394376959 0.633536595325776 0.861544344844802 True False False False False False False 0 insufficient_or_context_specific +LINC02362 -0.551637966330352 0.318770553838548 0.697529431591169 -0.767659348084058 0.15647463632347 0.539558215777 False False False False False False False 0 insufficient_or_context_specific +NCBP3 -0.195645682446922 0.319061758046311 0.697877365123875 -0.378668619330969 0.0449453098418042 0.393650849907072 0.7034083761137929 1.0 0.0921130743458809 0.738059229929372 -0.0243009319260332 0.919100420181174 0.0678121424198478 0.782180767762061 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC8B1 -0.21255739152299 0.319192942353471 0.697992602227829 -0.181221449494 0.399741163480599 0.729679668746226 0.608979668455407 1.0 -0.810450617345735 0.0478201511228984 0.426214533710922 0.223676882843322 -0.384236083634813 0.29188919953418 reversed False False False False False False False 0 insufficient_or_context_specific +MTERF3 0.329594524012824 0.319373005227719 0.697992602227829 0.418264819162761 0.211003725757926 0.583340491372659 0.0281567562463123 1.0 -0.344275561554105 0.316759520127399 0.0940731806263176 0.763816400139804 -0.250202380927788 0.42374836107536 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HLX-AS1 0.349144553321808 0.319441635846257 0.697992602227829 0.436125983067965 0.215343421384848 0.587852789707652 0.8864823071166401 0.9862358012049809 2.0 True False False False False False False 0 insufficient_or_context_specific +NLRX1 -0.25877366931126 0.319444994692638 0.697992602227829 -0.240457530922457 0.355450613770444 0.698854297986656 0.416368230084212 0.454800465437341 0.292754280651479 0.45866253403565 0.709122510735691 0.141391011251308 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EMC10 -0.27448342546026 0.319781617288037 0.698583553761037 -0.300666771033191 0.272397099125143 0.636388432952736 -0.037995273971069 0.912863180790051 -0.557320958880303 0.0310568195353952 -0.595316232851372 0.0297616020955191 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPS16 0.297738819908923 0.320113124999316 0.698784347635265 0.64137701802162 0.0234476179638738 0.348675986567013 True False False False False False False 0 insufficient_or_context_specific +IL1RAPL1 -0.503104590949753 0.320122398173236 0.698784347635265 0.145402374996326 0.761648774077946 0.916200040642014 False False False False False False False 0 insufficient_or_context_specific +AC006504.5 0.392702667652136 0.320138273300983 0.698784347635265 0.504610195666367 0.207843073429815 0.580700057930969 True False False False False False False 0 insufficient_or_context_specific +NDUFAF6 0.251898386506238 0.320353125131125 0.698830106468333 0.0805387088504025 0.760716780512581 0.915734238148068 -0.588036272146644 0.0685318682363885 0.213082227861354 0.444332987743193 -0.37495404428529 0.200938258967784 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HHIP-AS1 0.481824489797002 0.320480612348926 0.698953585040273 0.568658026710677 0.244967387399323 0.610669341516615 True False False False False False False 0 insufficient_or_context_specific +INVS 0.12713904232649 0.320614189874852 0.699100499111667 0.154608655503858 0.222881876007153 0.593969140017564 -0.200643895599301 0.565034087534571 -0.524962564494155 0.0738306569115781 -0.725606460093456 0.0303524188451113 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRDM15 -0.244596165327112 0.320910754143461 0.699310209095386 -0.0139813749470067 0.955393070723693 0.987410276805219 0.223324527421965 0.62749774598347 -0.534851647614746 0.132879794800002 -0.311527120192781 0.437717811219711 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DUSP11 0.239442599041513 0.321002671215333 0.699310209095386 0.295975292391755 0.219457111574359 0.592069212484543 0.6830550598231329 1.0 -0.341669966684241 0.158351679534532 0.266619727969159 0.210461195634219 -0.0750502387150822 0.760180017597096 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC37A4 -0.460353509479228 0.321041540394519 0.699310209095386 -0.312130101893153 0.507446776721796 0.794310314103592 0.409488440923242 1.0 -1.23304805490754 0.0237826878379918 1.18255125304757 0.0208643764921566 -0.0504968018599625 0.927177905708643 reversed False False False False False False False 0 insufficient_or_context_specific +AC010531.1 -0.401048120489451 0.321168825142575 0.699443163336491 -0.564098140203907 0.150283943480923 0.533583468169136 0.0213707065801398 1.0 False False False False False False False 0 insufficient_or_context_specific +NDRG3 -0.236002343136316 0.321301223981169 0.699468092160676 -0.152213044730918 0.521357750400304 0.801820120717612 -0.184566816254514 0.633475319510166 0.128637197769582 0.676969446155302 -0.0559296184849323 0.881663637320188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BMPER -0.455152627915775 0.32138004133253 0.699468092160676 -0.729182996980545 0.0993284689748535 0.478125555523304 0.600692166527598 1.0 0.9070121894939 0.156511497156519 -0.405314564434199 0.416343261725661 0.501697625059701 0.410350105518904 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNRNP70 -0.274318417503545 0.321445272131427 0.699468092160676 -0.314404096000362 0.253366963854158 0.618991529980024 1.19401987960868 0.9745544806091271 2.0 -0.173786628556069 0.634723797866651 -0.508873441725816 0.091235428620784 -0.682660070281885 0.0395419639524236 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HSF1 -0.214831481789661 0.321570934674536 0.699597347680559 -0.284650244831389 0.184753029023793 0.566601696256872 0.360617864311934 1.0 -0.255844416861112 0.298719294470336 -0.431610938478894 0.0564454586268416 -0.687455355340006 0.0119182685736954 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CISD1 0.272496964237061 0.321806401565796 0.699787065268571 0.473740322537902 0.0856847139884341 0.467503293000484 0.0317261771628744 1.0 -0.731813014094894 0.141308948124743 1.3880640914316 0.0085652364002083 0.656251077336709 0.147881724112397 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRPL55 -0.326679575936457 0.321949368023152 0.699787065268571 -0.431625280521986 0.184676682627374 0.566601696256872 0.285378294499601 1.0 False False False False False False False 0 insufficient_or_context_specific +DHX36 0.124888088489896 0.322205247278618 0.699967695631203 0.106244522441029 0.398343553219383 0.728766459000216 1.15142507345746 0.9658670593774459 0.0473110191251176 3.0 -0.37226180689104 0.145618043828569 0.0150343594418871 0.953581139558136 -0.357227447449153 0.13409927486184 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CTBP1-DT -0.282034229885085 0.322618934308111 0.700722219383879 -0.178246328170522 0.537058465099663 0.812087893451657 False False False False False False False 0 insufficient_or_context_specific +PCLO 0.709878615514291 0.322755971998301 0.7007346187993 0.931139786559756 0.22228200115161 0.593397884800048 True False False False False False False 0 insufficient_or_context_specific +TCP11L1 0.212834163551492 0.32276649995124 0.7007346187993 0.139595804949004 0.513176720119993 0.798308503171783 -0.0537505199276987 0.917945009132389 0.0458526988023286 0.904538829071086 -0.0078978211253701 0.986272547472679 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC02381 -0.336944464269509 0.322823753157776 0.7007346187993 -0.0202208711187865 0.953193877371715 0.987149466215884 0.7509879111119799 1.0 False False False False False False False 0 insufficient_or_context_specific +NCAPD3 -0.227068197728972 0.322893830140428 0.700742663642885 0.0154736933027371 0.944744467872496 0.985105732892783 0.68852585418929 0.111595734826675 -0.539166202826758 0.132060017151276 0.149359651362532 0.738399289449942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USO1 0.223455345328315 0.323365359002442 0.701169081972641 0.268295664710375 0.232785825560822 0.602604162857471 -0.174802135423099 0.509949372906553 -0.0592493565191424 0.801985333293392 -0.234051491942241 0.309031511968932 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PCBD2 -0.238865312257026 0.323371760251409 0.701169081972641 -0.172905576075586 0.477364270683757 0.778537650801879 -0.781492975122539 0.0134992236524402 1.1414102571395 0.0017101053550061 0.359917282016956 0.165680401713839 reversed False False False False False False False 0 insufficient_or_context_specific +DNAJC22 -0.344207104260394 0.32349219505954 0.701169081972641 -0.489065527745715 0.15342201970291 0.536502535641712 -0.122211309364438 0.80772018428236 0.49076812234835 0.168630844753096 0.368556812983912 0.328740284505899 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MCRIP2 -0.401338226913008 0.323552030283051 0.701169081972641 -0.343547189524062 0.401763530349658 0.730970076414215 0.510424120142992 1.0 0.0819556115791059 0.881220015404654 0.0368866222465361 0.932038782901976 0.118842233825642 0.789069118642163 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF140 0.152565515996635 0.323555196757976 0.701169081972641 0.004855354386919 0.976261542416929 0.992970766113577 True False False False False False False 0 insufficient_or_context_specific +FHL1 0.374044385807929 0.32380729755106 0.70145601563391 -0.405260665392944 0.303726981080075 0.661321811970186 1.61885832356955 1.0 0.112777990966287 0.755839978853224 -0.0841278290733127 0.775084435951439 0.0286501618929745 0.931785027561273 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBMS2 -0.170452559285711 0.323993890364735 0.70145601563391 -0.284155532944325 0.0959041243092452 0.47569521889622 0.477221945464574 1.0 0.004530317945291 0.991110564961989 -0.0355501859665419 0.904387017949864 -0.0310198680212509 0.922638935325517 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTC5 0.297688338566473 0.324073042600629 0.70145601563391 0.42706174191281 0.161291955109258 0.543541307772207 -0.0365962331143123 0.958832107692464 -0.628068714651532 0.195157978375258 -0.664664947765844 0.218839658885128 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ERCC8 -0.156101260763589 0.32408623264465 0.70145601563391 -0.0898937402544954 0.577763765250715 0.83075298180061 0.278726019748723 0.629324794015678 -0.0718245008654331 0.876912024662173 0.20690151888329 0.693949154361178 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC107072.1 0.496377364520236 0.324203267167542 0.701565504151448 0.517915799612521 0.304669278326465 0.661341495477036 True False False False False False False 0 insufficient_or_context_specific +STXBP5-AS1 -0.235890149909436 0.324460080678126 0.701877699823414 0.11001020759785 0.66877877898319 0.875941737812246 False False False False False False False 0 insufficient_or_context_specific +MIR4435-2HG -0.366183515235076 0.324546972015335 0.701877699823414 0.229861546900158 0.518744845752637 0.800840369846825 False False False False False False False 0 insufficient_or_context_specific +NCAM2 -0.490185274842623 0.324694957381697 0.701912732303227 -0.124873944685557 0.796653158784289 0.928937498275217 0.799661956413619 0.19820796309797 -0.114816684786439 0.815803260510834 0.68484527162718 0.236920006423524 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INTS1 -0.312192895411155 0.32480145886714 0.701912732303227 -0.365507333769886 0.247880819400373 0.613772441657865 0.35089778481166 1.0 -0.059815519148065 0.834089466860426 -0.229821184888164 0.252848433404802 -0.289636704036229 0.177904366749501 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GOLGA6L4 -0.362839701005771 0.324829097370105 0.701912732303227 -0.0057951104496331 0.990488075413462 0.997193963975906 False False False False False False False 0 insufficient_or_context_specific +ACTN4 -0.322973473698132 0.325199842488848 0.702354528183064 -0.510461468310634 0.118426429293741 0.498543158087445 0.6496060402375889 0.593952387318723 2.0 -0.133891430798842 0.730448388495279 0.246368884821113 0.413364402720864 0.112477454022272 0.741377534586068 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NIPAL3 0.344867929650119 0.32525199746634 0.702354528183064 0.246256264401962 0.480935014424632 0.780346070738476 -0.245758473499305 0.704756194917616 0.265498480164989 0.573904772092849 0.0197400066656847 0.975282086098756 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAGI1 0.213984531303577 0.32563527965744 0.702766199894736 0.262869836991597 0.226213721141381 0.598737645477739 0.417131111253326 0.470821344579596 0.281597484030277 3.0 -0.207490202216697 0.389668181517857 -0.2179008723538 0.286903647535095 -0.425391074570496 0.0619461920814249 partial_or_other True False False False False False False 0 cross_species_direction_conflict +STX5 -0.145005255209154 0.325671723041471 0.702766199894736 -0.0424065184415247 0.769562180817002 0.920286696658178 0.5615681340709611 1.0 False False False False False False False 0 insufficient_or_context_specific +MAOB -0.361296130289458 0.325689999629186 0.702766199894736 -0.366022786385288 0.319751882064129 0.672230261018136 -0.423658235128703 0.496000777998211 1.27718901302822 0.0202829901988581 0.853530777899521 0.106360270774186 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEC63 -0.148331259765027 0.326063290390886 0.70342791580445 -0.114273198491982 0.45285355578176 0.76491545430188 0.0525759129973288 0.852704750766105 0.268729141190871 0.173424661625072 0.3213050541882 0.126560867850228 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNBD1 -0.504626594871542 0.326152677688866 0.703454275022371 -0.534178866091786 0.298496685779442 0.656568335095699 False False False False False False False 0 insufficient_or_context_specific +MLPH -0.709383098069949 0.326218303042392 0.703454275022371 -0.743145641393224 0.301938894816414 0.65922243713362 -0.760648099670256 0.0974124050266379 0.157840851497299 0.708912326459481 -0.602807248172957 0.154076598664738 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GYPE -0.367249755039527 0.326326349688979 0.703454275022371 -0.39813791045291 0.287425363673436 0.647596455327388 False False False False False False False 0 insufficient_or_context_specific +SMG5 -0.223966251489104 0.326408646839799 0.703454275022371 -0.361217269736709 0.102261797279596 0.479137456027696 0.417750423493554 0.0924790364885474 -0.87003719308967 0.003145437360199 -0.452286769596116 0.0639059475217298 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYNE3 -0.26194516220863 0.326672499622881 0.703567204687985 -0.287747233772453 0.276455050895399 0.6396696093258 0.546930934050412 1.0 -0.526455366636943 0.34475600395944 0.0033139010279797 0.996065620952593 -0.523141465608964 0.299957725042372 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLL -0.293512497541529 0.326794238661667 0.703567204687985 -0.347414560711759 0.241322444951262 0.608572375975566 0.556651979470173 0.0284838273047226 2.0 0.227812178620767 0.756690979408215 -0.542214668527914 0.294245196569027 -0.314402489907147 0.625011527924497 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PNKD -0.218837107125295 0.32699522505756 0.703712920129988 -0.162011153868539 0.475738061731757 0.777735491146475 -0.500789029006385 0.142715724382876 0.328759771617992 0.27203325717718 -0.172029257388393 0.600045557868288 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TAOK1 -0.151455022878628 0.327209767494695 0.70388767832294 -0.142726921369059 0.354853472599037 0.698200328680699 -0.0693417622936249 0.810747289335757 0.166271228163524 0.420731293292911 0.0969294658698989 0.680506790512898 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NSUN3 0.214186266365397 0.327355364156662 0.704057432219603 0.045121221468278 0.835954688851036 0.946895140530977 -0.309109566321915 0.445704300556437 0.181606186227225 0.581902097632955 -0.12750338009469 0.7404978382261 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CIAPIN1 -0.267774613722082 0.327505544411826 0.704176414509987 -0.226515478665163 0.410477871147132 0.735152897523944 0.084729543201394 0.787132914197736 -0.222497329840752 0.327709206888863 -0.137767786639358 0.592463913116405 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDC7 -0.534261938032939 0.32756134562384 0.704176414509987 -0.354932282436632 0.514725230441662 0.798848899133572 0.496109587644515 0.837550905435143 2.0 0.436807826190849 0.407757678877119 -0.832178041068173 0.065037364451904 -0.395370214877323 0.428009115100869 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OCA2 -0.636163726764621 0.327610773638289 0.704176414509987 -1.04027564981227 0.091473770675333 0.472460751419842 False False False False False False False 0 insufficient_or_context_specific +SPAG1 -0.358341194483382 0.327849899227976 0.704401079318853 -0.27384877686128 0.457693723867398 0.76776776876263 False False False False False False False 0 insufficient_or_context_specific +C8ORF37-AS1 0.323350686510269 0.327890434548599 0.704401079318853 0.038779110425987 0.903605576697813 0.969539398249544 True False False False False False False 0 insufficient_or_context_specific +ZNF569 -0.240425745130216 0.327937035142482 0.704401079318853 -0.192497747595354 0.439003869067513 0.756012470366155 False False False False False False False 0 insufficient_or_context_specific +HEG1 0.241352995670117 0.328047239449451 0.704401079318853 0.331667794318243 0.181613540201932 0.564332404732057 -0.41621890727505 0.420251611082469 -0.400185113806094 0.362969827549662 -0.816404021081144 0.087109491740883 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DDX55 -0.223979631405987 0.328048883028112 0.704401079318853 -0.267253833528693 0.237829399449767 0.605329180588419 0.206983663376595 0.514583731261254 -0.768478603834584 0.011607751173525 -0.561494940457988 0.0595901789757225 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HMGN5 0.279833271827435 0.328214201757654 0.704473563779108 0.0636808728387519 0.82757811066488 0.942259214105446 -0.431489865430604 0.23500773375114 0.303765723774708 0.33183595595632 -0.127724141655897 0.722339331922986 partial_or_other True False False False False False False 0 cross_species_direction_conflict +APPL1 0.229004432486891 0.328350451127301 0.704618711992285 0.327607627553892 0.161406978918145 0.543541307772207 -0.0129764882453196 0.977260934134183 -0.401742225817515 0.192152850042874 -0.414718714062834 0.204181606804715 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC092902.3 0.397235448462037 0.328459967998407 0.704710494234338 0.686447381453251 0.0894021736859996 0.470746198832535 True False False False False False False 0 insufficient_or_context_specific +ORMDL1 0.19536924122831 0.328694146786841 0.70506964684589 0.14589056750731 0.46629793642543 0.771256747133237 -0.0930394834283337 0.869189748977706 0.718616461206197 0.0507937111338721 0.625576977777863 0.118868168104475 partial_or_other True False False False False False False 0 cross_species_direction_conflict +XAF1 -0.234234543519033 0.328809768238802 0.705174392253763 -0.251362083419572 0.294294875466474 0.652324662738756 1.50905710868618 1.0 0.203392361375386 0.682441736116258 -0.834215698200111 0.0451338338564942 -0.630823336824724 0.130816635151424 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MLX -0.34148153196713 0.328968096872862 0.705208718548861 -0.116762118241271 0.745146476882459 0.909500945159707 0.4049899912220371 1.0 -0.293501735559996 0.347936080103734 0.223929071958013 0.394303924847106 -0.0695726636019835 0.825574332282047 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBXN2A 0.15391892005533 0.328984298529235 0.705208718548861 0.200282041408775 0.199515969568235 0.575263953748573 -0.417904247166915 0.36218556900652 0.994653931321417 0.0172879552599406 0.576749684154503 0.146619929358671 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IP6K1 -0.167216638700403 0.329026155291882 0.705208718548861 -0.197017563484864 0.245848655064724 0.611033451076589 0.0860266090406991 1.0 -0.0870719420510553 0.759455697445548 -0.0780020703850973 0.731482935277939 -0.165074012436153 0.468358701141154 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADH1A -0.625757500453655 0.32912309623133 0.7052733204811 -0.239291267690794 0.716378034978729 0.897727094974894 0.566274136318485 0.2833265250157019 2.0 False False False False False False False 0 insufficient_or_context_specific +ZNF415 -0.429052722720007 0.329199975116003 0.705294914219716 -0.549970954397622 0.196502470349951 0.571879675616801 False False False False False False False 0 insufficient_or_context_specific +UROS 0.216956707148666 0.329622491064953 0.705770484823316 0.145042282819096 0.513767289589261 0.798491683514042 -0.0903442707073745 0.78479103405029 -0.561868131963079 0.0342785101277541 -0.652212402670454 0.027380568021304 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ADARB2 -0.60758365744146 0.329693160472016 0.705778667531133 -0.63140186569133 0.311386805886046 0.66389779817142 False False False False False False False 0 insufficient_or_context_specific +PLXND1 -0.253723621423796 0.329818848065105 0.705800529120071 -0.211660261682913 0.422160932901802 0.744017000089029 0.127175135566129 0.283059790871508 2.0 0.236885570214223 0.444978159545076 -0.158609259701235 0.547514202674971 0.0782763105129875 0.797580596753171 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AQP9 -0.673185317242209 0.329949895987996 0.705898885884753 -0.761467711635443 0.26862034198301 0.632915324850841 -0.810178407230212 0.0507255635149163 1.34522757268708 0.0041014806674381 0.53504916545687 0.149841324160335 reversed False False False False False False False 0 insufficient_or_context_specific +RPL37A 0.356494964857836 0.330091815492899 0.706059438406408 0.504880151179125 0.167545872015263 0.547623080618609 0.238076681773006 0.495683962662791 2.0 True False False False False False False 0 insufficient_or_context_specific +ADAMTS2 -0.214439684876406 0.330333116456029 0.706432457675259 -0.225479302272274 0.302803369303027 0.660051093047527 0.449162524501717 0.513992833573526 2.0 0.915090828472905 0.0073167868276031 -0.683562888886481 0.021692364869705 0.231527939586424 0.409553044197756 reversed False False False False False False False 0 insufficient_or_context_specific +AL645465.1 0.270866298289113 0.330519892266949 0.706568009779684 0.258086694962844 0.353402028057525 0.697398977158885 True False False False False False False 0 insufficient_or_context_specific +MFSD14C 0.146106057986497 0.330548637026152 0.706568009779684 0.0349158441378886 0.814834424075844 0.935641141872961 True False False False False False False 0 insufficient_or_context_specific +CCDC30 0.181629359000294 0.330725027873763 0.706568009779684 0.208790106075698 0.257260374633617 0.621906676979798 0.529350252973185 1.0 -0.447853210455564 0.45953068012708 -0.129286603974661 0.810342185379615 -0.577139814430224 0.282691472849988 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ST3GAL6 -0.452934833193502 0.330725669808416 0.706568009779684 -0.618734786922257 0.183457050692566 0.565541146173142 -0.313864289155198 0.770405194413138 0.468843753523394 0.517062493215772 0.154979464368197 0.868186934966835 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC35B4 -0.234598782135182 0.330827979060616 0.706568009779684 -0.249029386565119 0.300996062575004 0.658632920234719 0.780059397442796 1.0 -0.159589248571596 0.685693951862211 -0.0080398483156841 0.982326201083543 -0.16762909688728 0.62303817060341 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C21ORF62-AS1 0.262991353464735 0.330884016603802 0.706568009779684 0.117594128187376 0.660003967479168 0.872407073022888 True False False False False False False 0 insufficient_or_context_specific +AKAP8 -0.161967534677178 0.331086737511885 0.706568009779684 -0.272441307631232 0.0878711218131453 0.468622105620855 0.450393869034899 1.0 -0.24434273470646 0.373159582741915 -0.560641809545746 0.0307262134175377 -0.804984544252206 0.0091395773417082 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAPPC3 -0.228127019546874 0.331132588936805 0.706568009779684 -0.0612688635160271 0.798748518349943 0.92925379048471 0.547562125995453 1.0 0.202591964952554 0.587783169929522 0.210051127075012 0.470651438187045 0.412643092027566 0.191413802693045 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTL -0.29386795385643 0.331246136680925 0.706568009779684 -0.137241196652435 0.651892083940175 0.870123466781337 0.0915880810826854 0.85393026428381 -0.135204823415954 0.69375032129719 -0.0436167423332688 0.920638216930166 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IL7 0.50379210733864 0.331333416974732 0.706568009779684 0.976625350356813 0.0495459170593904 0.404880644205143 0.166774055729085 1.0 True False False False False False False 0 insufficient_or_context_specific +ALMS1 0.151270341915984 0.331478293444358 0.706679790006167 0.253449294853164 0.0980169470849453 0.478125555523304 0.0537827131497511 1.0 -0.0744857091633838 0.925059466657728 0.739833798925805 0.108069940374835 0.665348089762421 0.205450406753757 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COL24A1 -0.540108761011326 0.331585088655531 0.706679790006167 -0.461952800660553 0.407934862794002 0.734593849437939 -0.807827815728396 0.207432282713312 -0.0580380592797744 0.93068835591125 -0.86586587500817 0.147983846829189 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRGAP2 -0.208422666249021 0.331619123016678 0.706679790006167 0.0636323352176828 0.762344621519003 0.916603852905611 0.303083727450771 0.247335799425482 -0.408165534543258 0.0810809258185391 -0.105081807092488 0.687406299245416 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACYP1 0.284529458999846 0.331733473535319 0.706707428084322 0.114034194263252 0.697917401434577 0.889035426303613 -0.52031999467002 0.157385799907979 0.54342665376946 0.0855848027772051 0.02310665909944 0.952090132275007 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC005154.6 0.190877540716311 0.332082640302692 0.707308556852092 0.210044171014066 0.284524388096844 0.645322222516505 True False False False False False False 0 insufficient_or_context_specific +CACNB2 -0.331501178771844 0.332303707912656 0.707424157207511 -0.0224941082615606 0.946777365528141 0.985709044990249 0.0611217681645522 0.899256364282844 -0.721098090487961 0.0414837423384498 -0.659976322323409 0.0765411346673051 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC096887.1 -0.287395775237063 0.33234364550722 0.707424157207511 -0.155748601706157 0.603769570054409 0.845325437028836 False False False False False False False 0 insufficient_or_context_specific +LINC01428 -0.801737369643451 0.332978296029705 0.708119776699337 -0.52006802039074 0.542022087381917 0.813940850536852 False False False False False False False 0 insufficient_or_context_specific +ATL3 0.191004106755288 0.332999966631502 0.708119776699337 0.286099936001123 0.137582945656555 0.523810858054217 0.0302781525554409 1.0 -0.212221930194422 0.42260079855245 0.31632268734313 0.159767675359629 0.104100757148709 0.679055317676749 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KCTD21 -0.356281651306661 0.333007753498757 0.708119776699337 -0.33748813536211 0.361273027809909 0.703277731139138 1.05745388744681 0.859336833738672 2.0 -0.145621033634605 0.862435148401668 0.341875465793223 0.524786591895754 0.196254432158618 0.768255846359741 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CD163L1 0.355450047714411 0.333067134977165 0.708119776699337 0.0370370063430618 0.91899086776644 0.975930957742715 True False False False False False False 0 insufficient_or_context_specific +DUS1L -0.312794040369858 0.333171107854563 0.708198219595022 -0.290246610769035 0.370704919315322 0.709933692593666 -0.236043945075973 0.480575351919011 0.15187875696074 0.594290650622963 -0.0841651881152327 0.795678537542266 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF736 0.256699972591485 0.333296407836318 0.708321955301096 0.416570640904866 0.110573470356375 0.487854032604514 True False False False False False False 0 insufficient_or_context_specific +AC004889.1 -0.239939794083035 0.333583909653641 0.708790283381595 -0.437779421350226 0.0611241727686326 0.429419040318206 False False False False False False False 0 insufficient_or_context_specific +HPGD -0.458904241707518 0.333784542908014 0.70897163028834 -0.507728029833339 0.281866325446319 0.643169367638262 -1.60750029457798 0.0150596843885792 0.883297591344624 0.106630624482327 -0.724202703233353 0.188758850947986 reversed False False False False False False False 0 insufficient_or_context_specific +EHD4 -0.296877539418635 0.333945210331451 0.709129833201822 -0.570396724425381 0.0656457873901376 0.435533238803682 0.503034857582014 0.240241868911222 -0.178453643976418 0.605258176863272 0.324581213605595 0.418484096816969 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NARS2 0.250532252665014 0.334035827611545 0.709179623551717 0.173108982683732 0.50495969679892 0.792832263802515 -0.298274385546399 0.339736275985354 -0.132938799154935 0.62916535639451 -0.431213184701334 0.13409927486184 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CAPS -0.393193693956737 0.334333753203613 0.709266578146451 -0.593465547842429 0.13670057387909 0.523136620282319 False False False False False False False 0 insufficient_or_context_specific +DMXL2 0.224904780324335 0.334505490968156 0.709266578146451 0.473105740886566 0.0354393811704266 0.37720666979567 0.9058055884630669 0.0548894797872495 2.0 -0.618794250983018 0.0946616724159708 0.222727640714972 0.48899670814072 -0.396066610268045 0.239327096629281 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AP002026.1 -0.400751474844386 0.334562448349796 0.709266578146451 -0.249823130198504 0.549176794642229 0.816365047001981 0.0427825317611957 1.0 False False False False False False False 0 insufficient_or_context_specific +NDUFAF2 0.226842343491491 0.334596550316191 0.709266578146451 0.355259387761279 0.121483600564273 0.503485437181972 0.120166268451199 1.0 -0.176338994273936 0.53721383703171 0.0571772381104667 0.8189945010583 -0.119161756163469 0.647665578851794 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC073610.3 -0.333835642649798 0.334825633153571 0.709266578146451 0.0278575578359476 0.93673753170317 0.982574377153548 False False False False False False False 0 insufficient_or_context_specific +LINC02456 -0.662916365854412 0.334833481708192 0.709266578146451 -0.688061273561081 0.317266448616027 0.669290253214092 False False False False False False False 0 insufficient_or_context_specific +ZC3HC1 -0.211436823340687 0.334983728502759 0.709266578146451 -0.176463103339057 0.424204603948045 0.745464748416022 0.346902023631718 0.447360551794267 -0.432957311864465 0.224989900649603 -0.0860552882327477 0.856435874168073 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PON2 -0.183041771741754 0.335113231975041 0.709266578146451 -0.0583628164273926 0.759218790012223 0.915406319729464 -0.0283960902218564 0.962850315611004 0.53958210956268 0.182256737764881 0.511186019340823 0.235288020367028 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC49 0.262058585151154 0.335266958146682 0.709266578146451 0.0843287872988856 0.750620650530984 0.911659131290248 0.663266598923441 1.0 -0.411469796075772 0.520860017236944 -0.0266489442108477 0.964307556569782 -0.43811874028662 0.433471513431121 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HUWE1 -0.126180056074576 0.335468636378471 0.709266578146451 -0.0111069123550305 0.933633988513595 0.981304144333413 0.628653868555181 1.0 0.0209983090408463 0.948814985256369 0.010760696874275 0.966550931192472 0.0317590059151213 0.906222422502304 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIN3B -0.210833691796237 0.335591338707982 0.709266578146451 -0.284131174768149 0.184662919073886 0.566601696256872 -0.137476137206369 0.603562155863719 -0.239431252390995 0.260243642249069 -0.376907389597363 0.100441257201587 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NADSYN1 0.240214198095278 0.335615842942895 0.709266578146451 0.136932118763157 0.575666976587682 0.829928048970172 0.4750548631122121 1.0 -0.265077051261388 0.53757985276217 -0.123958552098592 0.735777866205971 -0.389035603359981 0.295260174361029 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC8A1 -0.334641305202671 0.335662858331546 0.709266578146451 -0.543941614276406 0.114071732883002 0.4924007041452 1.22446386076127 1.0 0.796182659853871 0.224256993413374 -1.48350007056983 0.021921334029822 -0.687317410715957 0.273743980120659 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRIF1 0.334005219582583 0.335808831453979 0.709266578146451 0.0639932733393054 0.848704836379757 0.953127856970211 -0.0839612122562808 0.888426793702172 -0.178012358345558 0.667009417475815 -0.261973570601839 0.568993324980417 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TAT -0.840344390024332 0.335841576394341 0.709266578146451 -0.994778848515346 0.253531401405255 0.618991529980024 -1.67634516530894 0.0054092946126062 1.12054365964421 0.0274208226545536 -0.555801505664733 0.240768356424804 reversed False False False False False False False 0 insufficient_or_context_specific +AL391117.1 -0.580821636930263 0.335915689424623 0.709266578146451 -0.764480366526294 0.202397452016781 0.57668584531318 False False False False False False False 0 insufficient_or_context_specific +TCF7L2 0.167349298235306 0.335957772050616 0.709266578146451 0.0896917578980821 0.608722282150467 0.848011761873084 -0.18908090507023 0.568506604854713 0.433755484828694 0.102669069808065 0.244674579758464 0.38128865084221 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRPM4 -0.298234943430496 0.336332954761311 0.709698913531051 -0.125592421822607 0.694582737159755 0.887499036540324 0.520843691332015 0.184169650286794 -1.30789511394707 0.0039566153281876 -0.787051422615055 0.0549703435601174 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF154 -0.378841246873016 0.336596256982888 0.709904770520441 0.194901235426684 0.620538878733183 0.854153589708151 False False False False False False False 0 insufficient_or_context_specific +SAT1 -0.406360451957748 0.336747323965705 0.710081535136791 -0.647151235248819 0.11491863540144 0.492615084274624 0.202469042235404 0.460052511109856 -0.141180105188284 0.543223787997289 0.0612889370471198 0.821178948278722 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTUS1 -0.216369301133549 0.336972930952678 0.710194818688764 -0.290776421583652 0.18595313739872 0.56775396895769 0.250435522545914 1.0 -0.460616971356708 0.0928837610594443 0.102225193591671 0.687607704785833 -0.358391777765038 0.157176244147384 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF638 0.130519305504154 0.337097165479015 0.710194818688764 0.131751048810555 0.329655185686956 0.678186271926176 0.0981743429227353 1.0 True False False False False False False 0 insufficient_or_context_specific +HERC5 0.490990092224339 0.337100177320259 0.710194818688764 0.168403881843001 0.740435509552976 0.908274440555399 True False False False False False False 0 insufficient_or_context_specific +MTBP -0.216981532363277 0.337117713811669 0.710194818688764 -0.0855366759708669 0.709974936960047 0.894500642532718 0.114712740153325 0.888756317097729 -0.324989485187009 0.547230267037784 -0.210276745033684 0.757360396466412 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP2B1 0.208701288632144 0.337137377464301 0.710194818688764 0.248235663596516 0.244921103203065 0.610669341516615 -0.0062396628042214 0.987029462321711 -0.0196916615993409 0.944326924427213 -0.0259313244035624 0.931785027561273 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ST7L 0.152895787886884 0.337410500577586 0.710628379233624 0.233801444728128 0.13933927887017 0.524285141237085 -0.097162012460096 0.819083985159194 -0.422925481830248 0.167107147567351 -0.520087494290344 0.116616930441397 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BMPR1B 0.294242571668542 0.337519407073471 0.710630836362177 0.169403038191618 0.581866279803626 0.833447860828475 0.727518293715544 1.0 True False False False False False False 0 insufficient_or_context_specific +FNBP1 -0.195593170901109 0.33755096033858 0.710630836362177 -0.152730820581449 0.458003552836685 0.767816418187074 0.144324144634441 0.731556142006226 -0.585792128940684 0.0807629273793783 -0.441467984306243 0.196081456563688 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNX25 0.191074221781036 0.337613589239693 0.710630836362177 0.184576685589684 0.35468992394611 0.698200328680699 -0.183824385953172 0.70232485713761 0.339349337330646 0.338491977894672 0.155524951377474 0.710025834253899 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CA13 -0.304402319191193 0.33772228508491 0.710717936202209 -0.06524995167017 0.839754898213246 0.948553783602808 False False False False False False False 0 insufficient_or_context_specific +ERCC1 -0.42807303331859 0.337924556309541 0.710750757272051 -0.681699294801689 0.135349694359411 0.521921867438516 0.7448322423063249 1.0 0.617721728464968 0.0659183754578961 -0.612278182020668 0.0407620513677333 0.0054435464443006 0.988437536981513 reversed False False False False False False False 0 insufficient_or_context_specific +LRGUK -0.332568592259517 0.337926779125835 0.710750757272051 -0.218115318925895 0.532164841486202 0.809129665381815 False False False False False False False 0 insufficient_or_context_specific +IKBKB -0.131311566389957 0.337979160243326 0.710750757272051 -0.196353750800887 0.154052657887153 0.53697192537886 0.359694561492144 1.0 -0.307154255961278 0.202066321336793 -0.52186695685735 0.02673045125685 -0.829021212818628 0.0053819116927464 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TGDS 0.263279385276441 0.338073744282869 0.710750757272051 0.143938257973101 0.602353965198478 0.844687629773613 -0.29619699443196 0.327207509215556 0.246835602204114 0.329862612981575 -0.0493613922278457 0.876324893409141 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CDYL2 -0.226347717621087 0.338074474618322 0.710750757272051 0.221398406026021 0.357438807046559 0.701288497271586 -0.455572656863552 0.205814568733279 -0.0697124822769456 0.840709977042864 -0.525285139140498 0.120832205923964 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACADSB -0.365905862286208 0.338184661309107 0.710756869291885 -0.503352718501589 0.18167890165602 0.564332404732057 -0.568863236773604 0.0260025188401845 0.915539666785228 0.0022783181439256 0.346676430011624 0.123610807808244 reversed False False False False False False False 0 insufficient_or_context_specific +PLAG1 -0.352839305021085 0.338212020394244 0.710756869291885 -0.331212095896953 0.371660775799045 0.710253546178141 False False False False False False False 0 insufficient_or_context_specific +RALGPS1 -0.266905439662711 0.338284614231117 0.710767951652166 0.109436195020487 0.70241989852403 0.891573566867428 0.7082886101457622 1.47519348682478 2.0 0.279425794976058 0.593222561167846 -0.141027751365589 0.730314840693736 0.138398043610469 0.780238176080744 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKRD20A3 -0.644229301038056 0.338512510006516 0.711105268732351 -0.48885885336985 0.473652303096918 0.776283920536675 False False False False False False False 0 insufficient_or_context_specific +TRAPPC11 0.171340612681277 0.338596211818424 0.711139606997996 0.148197200582575 0.406664610463343 0.733961461951707 -0.208312289174159 0.453807328242375 -0.287896169731635 0.215862804010478 -0.496208458905794 0.0563758928665735 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AK9 0.238924111232703 0.339002434831014 0.711659175579759 0.35369786357949 0.167239028868449 0.547506873424212 True False False False False False False 0 insufficient_or_context_specific +TRIT1 0.191078177908473 0.33917421708006 0.711659175579759 0.141526458935306 0.476892682656221 0.778277819446707 -0.229055850603256 0.599972823760722 -0.0238548512721791 0.95219240672187 -0.252910701875435 0.504024359134759 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MESD -0.219745503920498 0.339180618632066 0.711659175579759 -0.318022107993907 0.149426036686549 0.533583468169136 0.490117971033449 0.381922872825649 2.0 -0.55645388677364 0.0281625126624913 0.325102923570882 0.12843360882828 -0.231350963202757 0.297262589910834 reversed False False False False False False False 0 insufficient_or_context_specific +GCDH -0.41602769819765 0.339576664622721 0.712064728677573 -0.38767426674499 0.375237853000291 0.712931663123461 0.856496362359779 0.0258454757056667 2.0 -0.744520877271847 0.0965096303967632 1.12526380034679 0.0139951898468372 0.380742923074946 0.351430376517966 reversed False False False False False False False 0 insufficient_or_context_specific +AC016831.7 0.242012979174471 0.339579856883804 0.712064728677573 0.0079188827769246 0.975424312248477 0.99282077400168 0.0258817114691432 0.0550755219988819 2.0 True False False False False False False 0 insufficient_or_context_specific +PPME1 0.193050025658059 0.339633128285622 0.712064728677573 0.171429087881299 0.397269846670784 0.728024800638387 -0.11932360876957 0.709641136527112 0.214926059444504 0.375591533282856 0.095602450674934 0.735393396870212 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NOD1 0.294208141946638 0.339668443910243 0.712064728677573 0.399701617013888 0.194382497806438 0.571343735852293 0.546202050115112 0.364323413128179 0.106238341640039 3.0 -0.494438657664886 0.40719684227306 -0.475423438603469 0.353757529478003 -0.969862096268355 0.0815825919207785 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LRIG1 -0.297346672400533 0.33971112316243 0.712064728677573 -0.255002810648926 0.410200842551296 0.735152897523944 0.17220879338639 1.0 -0.464098783185351 0.130899869637614 0.295530177527443 0.258057477710361 -0.168568605657907 0.56235114565128 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RHBDD2 -0.372906098389844 0.339813207034935 0.712137324310212 -0.664020447061675 0.0680275947266429 0.43786261079484 0.90260980686134 0.7607379175992609 2.0 0.158626953474627 0.787386202931747 -0.227395010573734 0.602538512687415 -0.0687680570991074 0.898856991678616 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XPNPEP3 0.168392106575459 0.340023534851705 0.712273289486038 -0.0850899760640653 0.608370871429034 0.847936692532885 -0.475711164245411 0.203507690908736 0.152318419554106 0.651425780753177 -0.323392744691305 0.346020114135014 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF149 0.153323500352302 0.340117740026502 0.712273289486038 0.167574593389359 0.297158876646266 0.654889895570548 0.11633812127649 1.0 -0.109871687051623 0.758504046424184 0.12587759430551 0.651137206873242 0.0160059072538874 0.961966879758483 partial_or_other True False False False False False False 0 cross_species_direction_conflict +XRRA1 0.395149410714695 0.340150076770303 0.712273289486038 -0.237206105910989 0.557999598159085 0.821366572837071 0.776296002821464 1.0 False False False False False False False 0 insufficient_or_context_specific +EFHD1 0.479933861544195 0.340260013013708 0.712273289486038 0.0236349984313198 0.961113402170282 0.989172459774339 0.131093111729528 1.0 True False False False False False False 0 insufficient_or_context_specific +SHQ1 0.226121953676428 0.340376323837275 0.712273289486038 0.247174577905585 0.29642381090284 0.654189505750875 -0.633910741194364 0.172129406616575 -0.281469540035219 0.497927880185292 -0.915380281229583 0.0485463817063417 partial_or_other True False False False False False False 0 cross_species_direction_conflict +QTRT2 -0.262400807416975 0.340385716320328 0.712273289486038 -0.200722257842366 0.466421133779666 0.771256747133237 -0.257454137120489 0.380590591441404 -0.219572693727095 0.373832502368169 -0.477026830847584 0.0832614085386095 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM207A 0.360742789755048 0.340483914500718 0.712273289486038 -0.0138992299549715 0.971094996485161 0.992040338141303 -0.445254040521168 0.137197113942135 0.196089652479972 0.456312233998554 -0.249164388041196 0.366290580919471 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF737 0.321820132673122 0.340610067314986 0.712273289486038 -0.0417618802751389 0.900567305602252 0.968057977213875 False False False False False False False 0 insufficient_or_context_specific +SLC2A6 -0.345093785099088 0.340817505460614 0.712273289486038 -0.121566850600403 0.747704761336692 0.909897057421944 0.9882181130856501 0.27599549849108 2.0 False False False False False False False 0 insufficient_or_context_specific +AC005726.1 0.263390786009236 0.340944358139671 0.712273289486038 0.175473172546227 0.529117187381975 0.806487422314082 True False False False False False False 0 insufficient_or_context_specific +SEPT4 -0.307169634154199 0.3409609275308 0.712273289486038 -0.213145054411553 0.518976113893917 0.800840369846825 0.0669488008998443 0.894007251621826 -0.141759708513109 0.699986375642058 -0.0748109076132651 0.857233256423977 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL354696.2 0.386042144437738 0.340974479677688 0.712273289486038 0.200709865945495 0.621572120310067 0.854499797686678 True False False False False False False 0 insufficient_or_context_specific +SLC15A2 0.395015141671521 0.341005108601452 0.712273289486038 0.289835145652401 0.485074794201309 0.78154724869473 True False False False False False False 0 insufficient_or_context_specific +PLXDC1 0.403394628991812 0.341024955327896 0.712273289486038 0.45386496373923 0.286091851540102 0.64687121300967 0.5830017903683629 0.3752126377599529 2.0 -0.237315169289723 0.78897181771744 0.0391508324159443 0.955016050857929 -0.198164336873779 0.79586154970134 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MEG8 -0.266137499314618 0.341110958604128 0.712312005724365 -0.36748157120576 0.173157809514605 0.554336007536445 False False False False False False False 0 insufficient_or_context_specific +LINC00854 -0.513425310249099 0.34135384812248 0.712398992794396 -0.863329034560417 0.092641893117368 0.472460751419842 False False False False False False False 0 insufficient_or_context_specific +FAM96A -0.174750277903254 0.341416021463951 0.712398992794396 -0.331287143816537 0.0626029899496813 0.43268270867423 False False False False False False False 0 insufficient_or_context_specific +CYP3A5 -0.720601551373018 0.341420661086814 0.712398992794396 -0.989111331081545 0.187869030117282 0.56929178900529 False False False False False False False 0 insufficient_or_context_specific +TAB1 -0.208133598475508 0.341696520472002 0.712829848477256 -0.217651332444587 0.318661489175148 0.67087298159745 0.317578139434889 0.552348609348588 -0.214212003791617 0.601370426415146 0.103366135643272 0.844293963005993 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA1328 0.169786817894399 0.342054738290053 0.71329526503385 0.183940063084968 0.301079406686676 0.658632920234719 True False False False False False False 0 insufficient_or_context_specific +CGNL1 -0.205110547929472 0.3422108893534 0.713362068836113 -0.291934682958949 0.178891233634213 0.561794673286848 -0.196424902696771 0.500662008062218 -0.243158790246629 0.314178977613949 -0.439583692943399 0.0923888670855275 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM49A 0.243612707305579 0.342221905536552 0.713362068836113 0.228215589027295 0.372657547317705 0.711228919844601 0.387404719293266 1.0 -0.870007131855932 0.0576958887136675 0.585529386426537 0.141290333660845 -0.284477745429395 0.496137107385695 reversed True False False False False False False 0 cross_species_direction_conflict +SOX13 -0.197005774821492 0.342401970249951 0.713411344230341 -0.149408981712355 0.478064974430345 0.778545319644225 0.344284596662787 1.0 -0.396639923418019 0.25048105945282 0.0963494246281686 0.760575555362796 -0.300290498789851 0.341347737578318 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPRC5C -0.552494786427988 0.342462962165976 0.713411344230341 -0.675192877098084 0.242290915686796 0.608928228474458 0.532445317066944 0.7881631279423101 2.0 -0.524438289358622 0.0575428442719298 0.752028434276622 0.0086465489843832 0.227590144917999 0.35799006019017 reversed False False False False False False False 0 insufficient_or_context_specific +BBX 0.224868038311361 0.342583397920802 0.713411344230341 0.373059303146689 0.109310535355762 0.485176912870447 -0.312029318916921 0.301132840267642 0.0858639484996361 0.755180982454837 -0.226165370417285 0.411685008475087 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLG -0.584778783711783 0.342832975466605 0.713790288893002 -0.809276323825583 0.187283114709872 0.56929178900529 -1.22823104081116 0.0054359758108851 1.13853034597983 0.0069050590607853 -0.0897006948313376 0.820746829632542 reversed False False False False False False False 0 insufficient_or_context_specific +CREB1 -0.133579940828977 0.343140716940229 0.714290159592851 -0.130664702302145 0.352490553581005 0.696603122306959 0.0631589548887438 0.8481150306154 -0.205767221650793 0.368311499380993 -0.142608266762049 0.575766719737267 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATXN2L -0.218157064082352 0.343263613050131 0.714405130412632 0.037900422033424 0.868498229343674 0.958502690861149 0.349625529041842 1.0 -0.146375605179391 0.577904763167055 -0.203648582047909 0.339482838811027 -0.3500241872273 0.122104384902603 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXO31 -0.203021740411817 0.343583349601284 0.714507190287641 -0.244487480560498 0.243889858605358 0.610315684654444 0.182497880057954 0.3660840767222921 2.0 -1.11378921858473 0.0203094780196622 1.38924677672405 0.0050898248201365 0.275457558139325 0.495131319458432 reversed False False False False False False False 0 insufficient_or_context_specific +AP003108.2 -0.151466558051827 0.343823084169106 0.714724182448792 -0.140833976915769 0.376823963449244 0.714146007197471 False False False False False False False 0 insufficient_or_context_specific +NLRP1 0.409301845473404 0.344034802090103 0.714882786944953 0.306477656489081 0.480009354821741 0.780162456875056 0.186469345833649 0.0943630173187089 2.0 True False False False False False False 0 insufficient_or_context_specific +RRP15 -0.222649689855335 0.344272088748292 0.714886975735193 -0.0017506825381575 0.99419449981861 0.99854504652634 False False False False False False False 0 insufficient_or_context_specific +MKL2 0.1642873958249 0.344456269289841 0.714886975735193 0.364850788126282 0.0345202674331867 0.37720666979567 0.0889971803170766 1.0 True False False False False False False 0 insufficient_or_context_specific +CFHR5 -0.515304487535477 0.344457197884634 0.714886975735193 -0.800052327648363 0.13898362187059 0.524067528467748 False False False False False False False 0 insufficient_or_context_specific +STAT2 -0.253785212730095 0.344490372582487 0.714886975735193 -0.270767500621834 0.311970361886377 0.664337047357073 0.241742866959746 0.453098367577187 -0.585577284407314 0.0429128917643787 -0.343834417447568 0.229407973616812 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CIRBP -0.227500611375485 0.344587546166743 0.714886975735193 -0.24185673299808 0.314525543110324 0.666840881022273 0.365033085014901 0.0495686717043487 2.0 -0.53369542370314 0.219932855846463 -0.412863798291028 0.284133943547089 -0.946559221994167 0.0328447699088656 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM95B1 -0.571178279254205 0.344597115035361 0.714886975735193 -0.779246759317394 0.187374857446836 0.56929178900529 False False False False False False False 0 insufficient_or_context_specific +VPS13B 0.133485310028003 0.344676169799068 0.714886975735193 0.197573399809035 0.150741833790024 0.53368255534016 0.355523373624342 0.0965780144617627 2.0 -0.118605109859324 0.815171844574446 0.205606370780632 0.555631507400705 0.0870012609213077 0.840983930622384 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF283 0.259836695972664 0.344833394274837 0.714886975735193 -0.132768019886848 0.627861699969669 0.857992157257607 False False False False False False False 0 insufficient_or_context_specific +PRCD 0.38268811250999 0.345126807406056 0.714886975735193 0.489710678190757 0.231571033972884 0.601518427890281 1.52382571606769 0.7971177639431349 2.0 -0.327829956684184 0.639982538379121 -0.61406583265254 0.274273996479588 -0.941895789336724 0.132255085242081 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RRP36 -0.202703197240864 0.345197134712418 0.714886975735193 -0.243455706535505 0.252468434204348 0.618991529980024 0.8688187379423641 1.0 False False False False False False False 0 insufficient_or_context_specific +PKP2 -0.442693999400044 0.345272509254706 0.714886975735193 -0.662475501872946 0.144976301264057 0.532658823056677 -0.647104560006777 0.20409523221625 0.483074817548916 0.259060867588912 -0.16402974245786 0.741377534586068 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZBTB7B -0.421633148220923 0.345326861097893 0.714886975735193 -0.45676226488117 0.306533828934633 0.661696690217148 0.692430437790699 1.0 -0.0488754587770427 0.908928135185546 -0.167514269272202 0.567837002875239 -0.216389728049245 0.486096272272659 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCNT2 0.117958748347704 0.345327204747295 0.714886975735193 0.204203954778142 0.094672908151789 0.474551164587418 -0.133432616540181 0.677423150920228 -0.177706771052167 0.480934950461009 -0.311139387592348 0.236073793767468 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HNRNPH3 0.155618519179166 0.345559981712479 0.714886975735193 0.25493024814722 0.105231609528028 0.482830329046451 0.372085832765681 0.0588694513950067 2.0 -0.0253829279888575 0.943628346975369 -0.507834658770134 0.0487575712308209 -0.533217586758991 0.0511215287967508 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WDR81 -0.215065511929319 0.345602433776856 0.714886975735193 -0.231398413156294 0.309968063700492 0.663404108197172 0.531280436667252 0.744296827208624 2.0 0.0605438908965604 0.865727255314412 0.185533182858529 0.439132600032334 0.246077073755089 0.347617128195943 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SETD1A -0.227615116166595 0.345623275671847 0.714886975735193 -0.262388811908556 0.274798936307989 0.638427515212424 0.39143339850579 1.0 -0.351228699152032 0.147195882711345 -0.298991451514539 0.164011432010235 -0.650220150666572 0.0149202048528141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM179B 0.319573717588634 0.345883831236821 0.714886975735193 -0.0076067457284348 0.982979120833698 0.99451887511202 0.464491420972813 1.0 -0.181443540394786 0.692046018169297 0.217165357583859 0.527240076045847 0.0357218171890726 0.934701367288507 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GATC 0.430641829402881 0.345946318569383 0.714886975735193 0.315880684572273 0.486862091183818 0.782147598778917 0.583056385885537 1.0 -0.16415650157454 0.690038981640459 0.0080617330032031 0.982972032467422 -0.156094768571337 0.666117738757695 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DGAT1 -0.355686610310982 0.345975713143103 0.714886975735193 -0.182038082130294 0.636713505888144 0.862184533860645 0.440632669066039 1.0 -0.145945932871866 0.767493941585204 -0.130717736051995 0.725958881722397 -0.276663668923861 0.48849741629686 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MCL1 -0.310856711656957 0.346111885199359 0.714886975735193 -0.442806867367627 0.186191903979063 0.568159077889465 -0.087896689397272 0.814413161254705 -0.30972448008363 0.255067576440355 -0.397621169480902 0.165684750828936 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RFLNA 0.332043947433028 0.346167472488397 0.714886975735193 0.347419720192521 0.325837592655615 0.675077178818285 True False False False False False False 0 insufficient_or_context_specific +AC093151.3 -0.551231263253823 0.346255268495494 0.714886975735193 -0.57966070984301 0.321513813380353 0.672586257513328 False False False False False False False 0 insufficient_or_context_specific +APOA5 -0.487659343779198 0.346404869891678 0.714886975735193 -0.339385304040881 0.525140461794129 0.804676662787375 -1.5043937389145 0.003091207359983 1.43176022853278 0.0039566153281876 -0.0726335103817231 0.870298642859208 reversed False False False False False False False 0 insufficient_or_context_specific +TAF5L 0.246106013780476 0.346406683828495 0.714886975735193 0.137237077354187 0.600930140541538 0.84360251650955 0.335565369123607 1.0 -0.0076243222548223 0.986892057607086 0.288901928895019 0.295704388519505 0.281277606640196 0.362634098593055 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NUPR1 -0.226797117809321 0.346649211977072 0.714946525515973 0.0321298345697324 0.898849836712085 0.967837995533705 0.0303178262808097 1.0 -0.683050365276165 0.149087644180616 -0.18466237841181 0.674209864373547 -0.867712743687975 0.0604495210259736 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF558 0.20946904350283 0.346662409191311 0.714946525515973 0.0408555896461615 0.854227384261033 0.95526155065304 0.253421253423623 1.0 True False False False False False False 0 insufficient_or_context_specific +CLUAP1 0.187831571710863 0.34688781465891 0.714946525515973 0.127562794547474 0.515098131835989 0.799295425620867 -0.0822506590082057 0.805660088204716 -0.459384817918125 0.0661761778270251 -0.541635476926331 0.0494620076162028 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC01798 0.537458696673117 0.346953170349694 0.714946525515973 -0.14237529389087 0.798720536057974 0.92925379048471 0.591196360206126 1.0 False False False False False False False 0 insufficient_or_context_specific +SLC12A4 -0.30335347927939 0.346953895215394 0.714946525515973 -0.391641836158748 0.2222203371625 0.593397884800048 0.644785883797021 0.0405374476757864 -0.395528788658647 0.136643678719353 0.249257095138374 0.382178785396633 reversed False False False False False False False 0 insufficient_or_context_specific +KLHDC10 -0.158422334340483 0.34703703990131 0.714946525515973 -0.18598184848094 0.261783495450521 0.624330278962413 0.0725367434198566 1.0 0.0170726511823568 0.960850127566663 0.0810984635981893 0.747694400903901 0.0981711147805461 0.717627569281498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EDEM2 -0.218526976957324 0.347073432918515 0.714946525515973 -0.183903884065115 0.430680383116412 0.749361154407231 0.3907021029380811 1.0 -0.280779608117489 0.415856830616875 0.257438541930867 0.376787596895076 -0.0233410661866223 0.947820296272553 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC008591.1 -0.555733448600166 0.347295661756105 0.714947470919049 0.443327544623133 0.47231715038016 0.775593712997022 False False False False False False False 0 insufficient_or_context_specific +NUDCD3 -0.136802971152261 0.34735670248293 0.714947470919049 -0.0084795682867607 0.955669600994307 0.987410276805219 -0.164414301231356 0.52934335193034 -0.407809209796139 0.068871070498288 -0.572223511027495 0.0248774099173533 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL021368.2 0.372626237031798 0.347387208315674 0.714947470919049 0.395831736227289 0.319732007868647 0.672230261018136 True False False False False False False 0 insufficient_or_context_specific +DNAJC8 -0.222354702360782 0.347451740224061 0.714947470919049 -0.0644045741466505 0.797309753340627 0.92925379048471 -0.253930492350818 0.379748730165958 0.453537964036519 0.068803106182463 0.199607471685701 0.438701621477141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TATDN1 0.199164986791608 0.347662453503309 0.715241657070916 0.280123548946067 0.179934053751903 0.562759923872656 -0.360590768049049 0.307658764680924 -0.475572588940376 0.12732969543146 -0.836163356989425 0.0239449159381674 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CLIC4 0.246454037536916 0.347876806502904 0.715543215090134 0.152250303493975 0.568507678340408 0.825281707699499 0.315116842061774 1.0 -0.534853428567745 0.126894991227218 0.600414749417453 0.0616215833826196 0.0655613208497078 0.857883786313583 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RAB40C -0.24747817542602 0.348040733561814 0.715667621478906 -0.246883191795927 0.349247191653147 0.694288655897113 0.390700589981375 0.300101821482806 2.0 -0.49606384171779 0.14801957441232 0.207261965326137 0.480934950461009 -0.288801876391653 0.355894912340477 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ESR2 0.388003543558063 0.348072858144931 0.715667621478906 0.400976358898646 0.333487481049814 0.683290838901995 True False False False False False False 0 insufficient_or_context_specific +AC124854.1 0.406848558025227 0.348719591424851 0.716718210290748 0.269209583898223 0.537711586786632 0.812087893451657 True False False False False False False 0 insufficient_or_context_specific +AC008014.1 0.287204256598337 0.348980279113875 0.716874790974349 -0.164664398180331 0.594391594951086 0.839992833555557 False False False False False False False 0 insufficient_or_context_specific +SPEF2 0.233437349438126 0.349081656474233 0.716874790974349 -0.0245796055799799 0.919823084097425 0.976045355570903 0.310363774810306 1.0 False False False False False False False 0 insufficient_or_context_specific +RWDD4 0.298791120380622 0.349155636836365 0.716874790974349 -0.0388744596406618 0.899990775979123 0.968057977213875 False False False False False False False 0 insufficient_or_context_specific +GPCPD1 -0.369176031923756 0.349189896917825 0.716874790974349 -0.494538579891303 0.20346040229367 0.576835372560841 0.35822269100565 1.0 -1.65124888260228 0.0440171828477748 0.576044019395998 0.413988955215685 -1.07520486320628 0.140493350166708 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APOE 0.423692781390903 0.349203168211885 0.716874790974349 0.815293420408046 0.0807252042728527 0.460700922547448 -1.2035866840403 0.0901800745218741 1.32431954762126 0.0482338957458564 0.120732863580957 0.871967089234103 reversed True False False False False False False 0 cross_species_direction_conflict +TBC1D16 -0.250909386658409 0.349378723983723 0.71709404256344 -0.332559462015659 0.211073242661397 0.583379920423829 0.8503789148801221 0.505706385781228 0.0978540874180291 3.0 -0.153406841399378 0.698607036106686 -0.0555102013379603 0.872919594955843 -0.208917042737338 0.533992920999574 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADA -0.532500177417537 0.349456841929886 0.71709404256344 -0.173516760384748 0.765839718861201 0.919042481443119 -0.370310621943313 0.628807273711293 0.303384352683836 0.600197408285332 -0.066926269259477 0.927489221408977 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LEMD2 0.17381904474369 0.349594920438137 0.71709404256344 0.0634280983132401 0.733919141506334 0.90490695971317 0.6585471247709771 0.366780926532783 2.0 -0.117055450292543 0.630059356009784 -0.616224144823413 0.0088771675942206 -0.733279595115956 0.0061222386305539 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GRIP2 -0.625900843280183 0.34966488435933 0.71709404256344 -0.835815532521151 0.208444220034781 0.580837452798758 False False False False False False False 0 insufficient_or_context_specific +EDF1 0.211484614484681 0.349717486754987 0.71709404256344 0.381947386065906 0.0960958084096058 0.475855540112682 0.0353172359997174 1.0 -0.383777813148132 0.264365484844184 0.655922623482188 0.0418132405853145 0.272144810334057 0.385635170401749 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC01266 0.487377421427063 0.349829638109495 0.71710508088595 0.664234188007851 0.207751593289991 0.580700057930969 2.35976694947664 0.04480410636296001 0.0721988451308045 3.0 True False False False False False False 0 insufficient_or_context_specific +BLVRB -0.18830948943613 0.349858711085767 0.71710508088595 -0.132154081659686 0.517847385793365 0.800840369846825 -0.318673657241348 0.494831039821584 0.572590512622892 0.142339704992426 0.253916855381543 0.544338946509633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RSPO3 -0.538826000463206 0.350029607908436 0.717179760749628 -0.179955968258162 0.759771875923224 0.915406319729464 1.02829320779414 1.0 -0.430593472266544 0.273959847959256 0.033011485058356 0.93435451364595 -0.397581987208188 0.269129398628525 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTM1 0.185116342677962 0.350058762736283 0.717179760749628 0.107637520127739 0.585821737165026 0.83502769041167 -0.0360411353000538 0.936257534403958 -0.113048622011878 0.716575874665677 -0.149089757311932 0.665859310184658 partial_or_other True False False False False False False 0 cross_species_direction_conflict +STUB1 -0.280123254396979 0.350452409128834 0.717646325867628 -0.111884085397589 0.712183572046238 0.895497343705388 -0.230870335461332 0.361016579427362 -0.322298307827542 0.143520925879899 -0.553168643288874 0.029089243418065 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACO1 -0.1762564203616 0.350571414212632 0.717646325867628 0.0288470891152759 0.879612828427589 0.962079378694549 0.5945079864805699 1.0 -0.375282043948981 0.175382519309864 0.63352367802998 0.0206546699505345 0.258241634080999 0.310129378501062 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPL3 0.233028125220506 0.351255558398253 0.718364996516247 0.443333789815466 0.0696561530229382 0.441169564256857 0.0496968466359565 1.0 True False False False False False False 0 insufficient_or_context_specific +AC109779.1 0.587471048579221 0.351429210725342 0.718364996516247 0.61720093856562 0.329435080853304 0.678186271926176 True False False False False False False 0 insufficient_or_context_specific +PNPLA8 0.185694211850078 0.351516061107488 0.718364996516247 0.128989851269141 0.517833533947306 0.800840369846825 0.0547807694810783 1.0 -0.15163304756411 0.67399163617265 0.549427284313007 0.0582593285489462 0.397794236748897 0.174750557305252 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PUM3 0.210115583515887 0.351694461476613 0.718364996516247 0.365967061843488 0.0931233459011373 0.472709733823144 0.7229521799903241 0.5792276655466719 0.121329153522 3.0 -0.112926351528369 0.707255249318336 -0.090538285458582 0.708619412279665 -0.203464636986951 0.411580036046107 partial_or_other True False False False False False False 0 cross_species_direction_conflict +METTL2B -0.170201545170942 0.351698112047024 0.718364996516247 -0.115543489151031 0.534130698056636 0.810537816246747 False False False False False False False 0 insufficient_or_context_specific +SLC35E2A -0.234184131150384 0.351780232121321 0.718393750626093 -0.187630659646185 0.454146304570313 0.765695541335292 False False False False False False False 0 insufficient_or_context_specific +POLR3D -0.297272530248817 0.352070636678939 0.718569839949013 -0.402818608216858 0.19359922259197 0.570885363891703 -0.0618692450771108 0.895051221310091 -0.421154223026234 0.185710708865736 -0.483023468103345 0.165630276376653 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BRMS1L 0.182627347348439 0.3521634569384 0.718620366902905 0.0723037011231102 0.720642906670081 0.9002067923122 -0.157590057956362 0.732619581388593 -0.694091528011859 0.0629626311295878 -0.851681585968221 0.0391192924005971 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PPP1R13B -0.133757864410006 0.352381406908108 0.718640946452047 -0.114228678112779 0.42835376626735 0.748024985817181 -0.130643681565556 0.753524701781821 -0.302527295393858 0.32555898290503 -0.433170976959414 0.194093119192605 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZSWIM8 -0.183795298062267 0.352539579500792 0.718640946452047 -0.173243260536739 0.381083535493876 0.717325720760268 0.0423797381113648 0.909561233524486 -0.634005170559393 0.0250141074835875 -0.591625432448028 0.0399399924262679 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRP12 0.335882504700363 0.352544980909071 0.718640946452047 0.275357596024864 0.445992750165233 0.761078302286169 0.5437758719471429 1.0 -0.563586578631525 0.326346748507932 0.169700706090378 0.738778587855958 -0.393885872541147 0.448599088574639 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC10A1 -0.604353670989321 0.352581938115325 0.718640946452047 -0.659382489211984 0.30901964543057 0.66273195540442 -1.60153609381542 0.0123707633488523 2.39635540975677 0.001541021056078 0.794819315941346 0.11897894258647 reversed False False False False False False False 0 insufficient_or_context_specific +TNFRSF11B -0.403743077336109 0.352869956894604 0.719089172918979 -0.086825444862134 0.843283808084641 0.9506514118099 0.372005655071788 0.429163567942419 0.0757300480715364 0.864849966799431 0.447735703143324 0.282314926094076 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCND3 -0.252115173499175 0.353405100925331 0.720040728593138 -0.161036584201379 0.555788830355656 0.820532411837013 False False False False False False False 0 insufficient_or_context_specific +ATP6V0B -0.315809807333035 0.353563554838638 0.720224582671492 -0.21285909647664 0.5377067962041 0.812087893451657 0.352898421965408 0.160798809911724 -0.372527460757232 0.0985944114091429 -0.0196290387918244 0.942530864088853 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC022101.1 -0.699166876978115 0.353724213986613 0.720273915384891 -1.03658653395119 0.159093757378955 0.543060696740211 False False False False False False False 0 insufficient_or_context_specific +PPIH -0.247529123902368 0.353962353813962 0.720619847969111 0.038556285288168 0.881997774998224 0.962655003796147 False False False False False False False 0 insufficient_or_context_specific +ZRANB3 -0.156726839508059 0.354179998710973 0.720923930285415 -0.0529352442958933 0.757026540869921 0.914454644719928 0.689282420968656 0.328799881592561 -1.4026071623128 0.0308307222802141 -0.713324741344147 0.334370942414574 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIR646HG 0.35488190667452 0.354461995928557 0.721028182910501 0.65199307946391 0.102151295058033 0.479137456027696 True False False False False False False 0 insufficient_or_context_specific +AGO4 0.156745794110471 0.3545456037533 0.721028182910501 0.0005968464564715 0.997168800009865 0.998795540446485 -0.137718098057979 0.837782262920856 -0.544019148389442 0.242253826653559 -0.681737246447421 0.194546743898624 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAAH -0.294411156266321 0.354632364822833 0.721028182910501 -0.28994160110402 0.362779368226245 0.704473895481459 -0.991270006883439 0.0488924381808764 0.852668469762525 0.0601048928053617 -0.138601537120914 0.77967450345531 reversed False False False False False False False 0 insufficient_or_context_specific +KIF13B -0.15568579429412 0.354640969298563 0.721028182910501 -0.143699425060423 0.393623203106515 0.725409980519913 0.318957381395883 1.0 -0.307424037494777 0.254771541846249 0.287828792070497 0.218459201873378 -0.01959524542428 0.945443098692126 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PGBD1 -0.294415241104971 0.354959862540421 0.721398696573969 -0.209205440200729 0.518139402693136 0.800840369846825 False False False False False False False 0 insufficient_or_context_specific +PLEKHH2 -0.273620293447917 0.355180896291453 0.721537867317966 -0.447269805909013 0.136100754190083 0.523136620282319 -0.17686839536242 0.59986758070121 -0.0457336903732171 0.884042308558433 -0.222602085735637 0.438464520192136 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EAF2 0.370839112793276 0.355244274094082 0.721537867317966 0.24063049343155 0.539603388210374 0.812783927483158 True False False False False False False 0 insufficient_or_context_specific +LINC02284 0.501211490080991 0.355641598342804 0.721537867317966 0.741374842481655 0.175447451031076 0.557440321392147 True False False False False False False 0 insufficient_or_context_specific +COG4 -0.172312483158051 0.355707298293411 0.721537867317966 0.0436375034252766 0.826402602148579 0.941936594352229 -0.210486463736825 0.531879301622403 0.296351246382896 0.263195519310715 0.0858647826460704 0.787384351631065 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NRDC 0.139003851362605 0.355818817375733 0.721537867317966 0.251610466927902 0.0798012525691746 0.45963008362507 0.130380728376352 1.0 True False False False False False False 0 insufficient_or_context_specific +MALSU1 -0.179926500271625 0.355946603635513 0.721537867317966 -0.389835578640237 0.0371050884820272 0.379484931484566 False False False False False False False 0 insufficient_or_context_specific +LYRM1 0.351462510183201 0.356237260234264 0.721537867317966 0.400683270779405 0.295672078777694 0.653127785976999 0.749756221630972 1.0 True False False False False False False 0 insufficient_or_context_specific +BTN3A3 0.286526149859364 0.356403551095723 0.721537867317966 0.173225634743654 0.580909526218201 0.832868383733265 True False False False False False False 0 insufficient_or_context_specific +TMEM63A -0.1646904490879 0.356410047078861 0.721537867317966 -0.308408351591798 0.0768333863620544 0.455668688469891 0.335161752229691 0.491060251943551 -0.622463872857047 0.12305970962616 -0.287302120627356 0.516503111686054 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCF3 -0.407320481392482 0.356420340549226 0.721537867317966 -0.784980619933049 0.0529115825172361 0.416277817549129 -0.48704826617449 0.0392318587037892 -0.162333031409505 0.423313114166727 -0.649381297583996 0.0117660635025593 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GABPA 0.310143178656354 0.356439980825415 0.721537867317966 0.526251148458712 0.122718107310105 0.504082700851544 0.0393180852762674 1.0 -0.347605048601732 0.268445622372792 0.411400579680326 0.128732653862785 0.0637955310785937 0.843188603495081 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PTGES2 -0.381863715879202 0.356499868012492 0.721537867317966 -0.0810210730793579 0.851238617466529 0.953856209560787 0.5854206566917081 0.254640041962764 2.0 -0.369394503901468 0.360603358387762 0.0058059936972173 0.98880341142216 -0.363588510204251 0.31724860406802 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MED25 -0.246921186455594 0.356505721975853 0.721537867317966 -0.382474613709762 0.141587647643128 0.526923646040233 0.898630012405909 1.0 0.0934897443711312 0.720111361869049 -0.207731647206532 0.298123821774826 -0.114241902835401 0.608119365637099 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPLD1 -0.484728522565669 0.356571186179322 0.721537867317966 -0.357836089771025 0.500833711151759 0.790819493321426 -1.33935405772999 0.0155295141127712 1.49175074617092 0.0070628553585345 0.152396688440935 0.762158108262382 reversed False False False False False False False 0 insufficient_or_context_specific +FBXO7 -0.19980163812735 0.35659788391408 0.721537867317966 0.0172815148177309 0.939203523868977 0.983643567603279 0.500306679892575 1.15271422022286 2.0 -0.104999826965692 0.790249002791818 0.396910845870499 0.150826116251216 0.291911018904807 0.331913343452848 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAST3 -0.217332489043034 0.356653816196046 0.721537867317966 -0.174721505181565 0.463110372177831 0.769320698854699 0.0372143246880262 1.0 -0.29088736356646 0.461359526939275 0.087901678510573 0.804491446852078 -0.202985685055887 0.573482375993874 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF216 -0.116107896963647 0.356723353804098 0.721537867317966 -0.110664547528598 0.377805778086495 0.715214004833462 -0.175089646919862 0.502201655412224 0.160545653287275 0.452219991523842 -0.0145439936325868 0.956072753786351 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM182B -0.188225768566445 0.356916032750525 0.721537867317966 -0.307824113609174 0.125859528484521 0.507996233320616 False False False False False False False 0 insufficient_or_context_specific +WDR82 -0.180776334447893 0.357115740501694 0.721537867317966 -0.332452843618306 0.0699230437460263 0.441799817995539 0.22932642099429 0.545512510096433 2.0 0.059339214106476 0.885896209712577 -0.114492683627053 0.701968805060432 -0.0551534695205769 0.87581843078712 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BORCS5 0.185206806217557 0.357145322891168 0.721537867317966 0.171861332789172 0.393807525180528 0.725496396938757 0.9578471572431658 1.0 -0.519600909694707 0.136016524461816 0.472829569122906 0.11351819191776 -0.0467713405718009 0.898639948903107 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NOM1 -0.192108953323474 0.357198918469996 0.721537867317966 -0.140912422433612 0.49878768103045 0.7899705952391 -0.0052260814885916 0.990328472561252 -0.4831484910708 0.09004146456268 -0.488374572559392 0.110328112039623 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC106795.3 -0.581750206978347 0.357204520252529 0.721537867317966 -0.959939497262448 0.107249545544262 0.483286684531078 False False False False False False False 0 insufficient_or_context_specific +AL139021.1 0.410170197808455 0.357216704302956 0.721537867317966 0.65454933729255 0.142503155318529 0.528011532230573 0.0195569009947287 1.0 True False False False False False False 0 insufficient_or_context_specific +NMRAL1 -0.278004793601408 0.357243692153342 0.721537867317966 -0.541352335839168 0.0537609231446838 0.417665803209397 0.561876844238669 1.0 0.45830216636806 0.390507937606139 -0.532790631717753 0.208589517138224 -0.074488465349693 0.898111337473259 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TOM1L2 0.142314177251634 0.357354376627194 0.721537867317966 0.0993207239240385 0.521907368452271 0.802314792678957 0.309357455203516 1.0 -0.0062692418599624 0.986175817145497 0.0324851553539106 0.904387017949864 0.0262159134939482 0.927776471045221 partial_or_other True False False False False False False 0 cross_species_direction_conflict +YTHDC1 0.178561217317203 0.357390072208311 0.721537867317966 -0.0072372902827601 0.970171864337289 0.991969256602082 -0.042896721002314 0.889917187930316 -0.323233978350074 0.134179696407134 -0.366130699352388 0.114936558589373 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STRN3 -0.125012349447866 0.357411682460776 0.721537867317966 -0.114709287560105 0.395212861062073 0.726274872614038 0.0839954776274663 1.0 0.104567637193518 0.70232485713761 -0.0281376345332386 0.908885884946928 0.0764300026602794 0.756482372894164 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PINK1 0.28020812566032 0.357420254411154 0.721537867317966 0.13538589482885 0.652303241296617 0.870374832458737 -0.718138829777079 0.112143512745841 1.06650580618159 0.0182769117749003 0.34836697640451 0.399251098964532 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LRP2BP 0.385158074767484 0.357776821177722 0.721812434295044 -0.051194478190402 0.903300616430142 0.96950635453002 False False False False False False False 0 insufficient_or_context_specific +AKT2 -0.144542469582729 0.357791354816458 0.721812434295044 -0.25243517792891 0.103777738309573 0.479932265033934 0.541615673428085 0.449952901635284 2.0 -0.194996030357852 0.429844522747538 0.334124933195392 0.108101526914439 0.13912890283754 0.536131536516389 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRKCD -0.239190541671293 0.35785954307221 0.721812434295044 -0.383396718399235 0.136482690110413 0.523136620282319 0.310070136799793 0.351018789821951 -0.710280582186761 0.0246079859153381 -0.400210445386968 0.191732222501831 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACAD8 -0.235775864116771 0.357898095617973 0.721812434295044 -0.306955393382996 0.218545762297102 0.590885059752319 -0.489137154068546 0.164903329043927 0.402789949976433 0.189799867813803 -0.0863472040921134 0.81076171344791 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MT1G -0.567954909523624 0.358195569944335 0.722136495602882 -0.867606999931678 0.156660249082574 0.539558215777 False False False False False False False 0 insufficient_or_context_specific +AC099329.3 0.343047116876679 0.358640374504114 0.722459065655611 0.428580990568578 0.254263259144358 0.619121653608424 0.0115244456730146 1.0 True False False False False False False 0 insufficient_or_context_specific +GBP1 0.546409475102904 0.358672805432216 0.722459065655611 0.251819519035701 0.676320612227403 0.879146834479876 0.482935025705058 1.0 True False False False False False False 0 insufficient_or_context_specific +RPTOR -0.134333982720312 0.358888223980041 0.722459065655611 -0.131516443788702 0.367559545835854 0.708317354196916 -0.487699455295179 0.0758732483701552 -0.4908688109251 0.0555251282111667 -0.978568266220279 0.0044835029942636 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OSBP2 0.298568875447741 0.358974343791087 0.722459065655611 -0.0115487541479732 0.97385491688909 0.992450915625761 False False False False False False False 0 insufficient_or_context_specific +MINDY1 -0.276061458602154 0.359186171611175 0.722459065655611 -0.406385588303217 0.169854328800425 0.550151003380263 -0.329749930403814 0.160798809911724 0.238360358810909 0.242807847868865 -0.0913895715929048 0.69469544116432 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP39A1 -0.612695993015261 0.359297407316353 0.722459065655611 -1.15246671465491 0.0752598046263218 0.453382804479479 0.0805832908088703 0.911240264788933 0.6515121054705 0.149197160132819 0.73209539627937 0.146369950423067 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IPO11 0.152220972082517 0.359437715340097 0.722459065655611 0.217120829248188 0.189527343408766 0.569886897607216 0.417034196477906 1.0 -0.347695933386798 0.458054227425406 -0.0842654565383531 0.842963181236858 -0.431961389925151 0.296442483395134 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IQCH 0.277511368252174 0.359438372011069 0.722459065655611 0.345144115796867 0.258175888931028 0.622136927842961 True False False False False False False 0 insufficient_or_context_specific +PRDM16 -0.336862080361781 0.35947919191367 0.722459065655611 -0.423452922444764 0.246001953414533 0.611270563462142 False False False False False False False 0 insufficient_or_context_specific +ATG4B -0.172774356739963 0.359612831660855 0.722459065655611 -0.252155285693269 0.180682657501625 0.563538010872213 -0.276462394081845 0.326855370011508 0.0170401035943793 0.951896989210669 -0.259422290487466 0.311419746297775 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NEK10 0.41199451526756 0.359655697015144 0.722459065655611 0.691688584494723 0.145954909260919 0.532796338690088 True False False False False False False 0 insufficient_or_context_specific +EDRF1 -0.184914475371169 0.360237717158161 0.723352951265854 -0.160604615966448 0.428513714590633 0.748096383458709 0.401322564001067 1.0 0.401924122102154 0.186203983345178 -0.52032055353518 0.0536791848755973 -0.118396431433026 0.704157063557181 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS9 0.241587707576394 0.360370791745369 0.723453302922092 0.121234849583268 0.648245633507238 0.86855377695836 True False False False False False False 0 insufficient_or_context_specific +CDAN1 -0.206444214265629 0.360442698266602 0.723453302922092 -0.143610140211307 0.530143625813354 0.807335410549169 0.351799029105739 0.252285662017836 -0.889932607813762 0.006803635808275 -0.538133578708023 0.0752347470231496 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC005037.1 0.326157606295344 0.360497136433706 0.723453302922092 -0.180504095753838 0.579093667361122 0.831827949124047 False False False False False False False 0 insufficient_or_context_specific +COX7A2L 0.267554055337299 0.360680885779098 0.723453302922092 0.535944010676598 0.0798410279757888 0.45963008362507 0.48027129609022 1.0 -0.227004655553559 0.596645525518447 0.473522234868482 0.169976536273377 0.246517579314923 0.503388747149237 partial_or_other True False False False False False False 0 cross_species_direction_conflict +P4HA3 0.46748671118652 0.360709154288547 0.723453302922092 0.769776683615886 0.134337606524247 0.520900171021663 1.3781087147667 0.036538172587986 2.0 True False False False False False False 0 insufficient_or_context_specific +LINC01252 0.540284745572863 0.360712025984795 0.723453302922092 0.978419270897914 0.0944648858018445 0.474522823037106 0.0402483089715794 1.0 True False False False False False False 0 insufficient_or_context_specific +ARSB -0.197620435516924 0.360890885492254 0.723453302922092 -0.200646125626308 0.353516047509929 0.697398977158885 -0.180761516960717 0.654533866508828 0.473545022016471 0.127967431434032 0.292783505055754 0.375315122981696 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NTF3 -0.349270825700019 0.360929030160507 0.723453302922092 -0.382886552880766 0.31582504744592 0.668002877965535 0.17504494628672 0.71298330450532 0.21190212960588 0.547750736161489 0.3869470758926 0.312567192566721 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP49 -0.217967654830939 0.36094477552234 0.723453302922092 -0.116221721611688 0.628784096863603 0.858472266510466 -0.197997728529236 0.771944813856316 -0.268225360539269 0.598112459548743 -0.466223089068505 0.397745789572118 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP001011.1 0.354282986580963 0.361000266673139 0.723453302922092 0.465318583968145 0.233739587186837 0.602697571243329 True False False False False False False 0 insufficient_or_context_specific +ZFAND2B -0.267908416694352 0.361041433329845 0.723453302922092 -0.267543010334569 0.361877680823815 0.703533322359016 -0.330559685049515 0.238221656284649 -0.0616444759178707 0.816948466455774 -0.392204160967386 0.133467274422914 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CARD11 0.558623725969719 0.361833033844324 0.724764403591041 0.280553573854721 0.640380078709391 0.864640237429136 True False False False False False False 0 insufficient_or_context_specific +GPALPP1 0.179705750550515 0.362030534260614 0.725022454613726 0.249800701476201 0.201498541586826 0.57622470262018 -0.0424013822039934 0.918038755247294 0.163976791662652 0.545024089690209 0.121575409458658 0.698821663329647 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TPST1 0.214641606012734 0.362535910237216 0.72581667682749 0.354414793177001 0.11162710623035 0.490045317081098 1.23716836694387 0.224820077851645 0.173879953830271 3.0 -0.389208784408657 0.086085848856072 0.569634126966541 0.013346413238883 0.180425342557884 0.385147537419382 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WLS -0.221726255912911 0.362577706748112 0.72581667682749 -0.417794752154149 0.0768496858611893 0.455668688469891 0.418459614443721 0.173743749334662 -0.323867553258945 0.225442413043454 0.0945920611847758 0.763815569716572 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF219-AS1 -0.256867690543409 0.362821282466398 0.72581667682749 -0.184139972008333 0.510796296021096 0.796519013040946 False False False False False False False 0 insufficient_or_context_specific +LPCAT3 -0.190477833990828 0.362831369434374 0.72581667682749 -0.220691984042454 0.290707029121857 0.650001487250975 -0.214270514806886 0.453058208074121 0.420997983189468 0.0804252692150052 0.206727468382583 0.408399144887828 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FRMD8 -0.235161787623242 0.362839592753883 0.72581667682749 -0.0928454238233864 0.724807851930322 0.902751186327241 0.387604442168865 1.0 0.278837725961363 0.317934656023734 -0.384434792053851 0.111188850252914 -0.105597066092487 0.702966276390426 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DUS2 -0.206605597993466 0.362997132106903 0.725994264213807 -0.297881453064545 0.178615895241088 0.561600025036498 0.159479376734525 0.768408825074034 -0.146450469164636 0.710409058708838 0.0130289075698881 0.980873751510795 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COL6A2 -0.18168618427238 0.363374951738417 0.726225972075048 -0.0757364209448202 0.712591069211308 0.895497343705388 0.7924475305775741 0.7445351467133191 2.0 0.16410700400385 0.664025509525899 0.162446971243538 0.592920559221651 0.326553975247388 0.293014502556742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC024901.1 -0.387443311374463 0.363388123742421 0.726225972075048 -0.397681896012088 0.350621598447265 0.695446709826455 False False False False False False False 0 insufficient_or_context_specific +LINC02398 -0.422249273895742 0.363617637725899 0.726547127007956 -0.382547878897704 0.412085495073592 0.735291083225579 0.403510536943547 1.0 False False False False False False False 0 insufficient_or_context_specific +ZHX2 0.17952831305408 0.364140060410329 0.727453312736473 0.131032513914186 0.509492076442495 0.796280409399204 0.778748759332855 0.193762696277249 0.110492420660833 3.0 -0.764785703202927 0.0317762801738563 1.15822170642472 0.0032980079547928 0.393436003221793 0.196010290284305 reversed True False False False False False False 0 cross_species_direction_conflict +KCNQ5 0.550023958396625 0.364252338674336 0.727539953031335 -0.522653917042428 0.37011481151194 0.709652000364538 False False False False False False False 0 insufficient_or_context_specific +PHC1 -0.201745934402743 0.364381637685781 0.7276605505365 -0.0694349619855999 0.760710213778706 0.915734238148068 -0.14077045152414 0.735196936139036 -0.248323898032501 0.418840281370459 -0.389094349556641 0.251937510247415 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LHFPL2 -0.21748618561193 0.364457684209651 0.727674778722674 -0.103922804040342 0.657770714378854 0.871691185476023 1.25000424362197 1.0 0.417662033980645 0.159351274500249 -0.4241981029041 0.100149256514641 -0.0065360689234548 0.985382269856691 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DZANK1 0.359893626072972 0.364639740504125 0.727900620200898 0.333656594425387 0.402623710496044 0.731526610810055 True False False False False False False 0 insufficient_or_context_specific +GON4L -0.115277673939671 0.364718426514899 0.727920065622742 0.0092388545432749 0.942551017300443 0.984366565940656 0.0887312264916667 0.731556142006226 -0.806551829631708 0.0030860998178599 -0.717820603140041 0.0075508193403489 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC073389.2 0.507639345301296 0.364889079254897 0.728123019991156 0.183985225714609 0.742311723534551 0.909097225040922 True False False False False False False 0 insufficient_or_context_specific +SMIM4 -0.221511432237717 0.365029203533237 0.728194059214707 -0.0053071871644967 0.983512987344743 0.99451887511202 0.273208973549419 1.0 -0.234275404383199 0.320349903765884 0.444345464198731 0.0398482734633108 0.210070059815533 0.322268417765682 partial_or_other False False False False False False False 0 insufficient_or_context_specific +QTRT1 -0.372331314464194 0.365131592108606 0.728194059214707 -0.569775558727726 0.160340245116468 0.543541307772207 0.0238524135118604 1.0 0.268584640807093 0.560983902319736 -0.856623460885313 0.0332557467940062 -0.58803882007822 0.157700527672553 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL42 0.183093769110346 0.365329720728583 0.728416718695005 -0.211618933679492 0.31334055822182 0.665911757992347 0.214342445349019 0.610564993474888 -0.0514532558505203 0.888095273152991 0.162889189498499 0.668060032826326 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FGF10 -0.477768573405544 0.365490354497012 0.728416718695005 -0.681727701061721 0.194496020375828 0.571343735852293 False False False False False False False 0 insufficient_or_context_specific +MAP3K1 -0.231156099406143 0.365530157503197 0.728416718695005 0.0719580951223578 0.775691194775196 0.92226887775186 0.5420360176486161 1.0 0.358947949773228 0.258123784509918 -0.560483925587138 0.0519381891771047 -0.20153597581391 0.50413283499357 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TAX1BP1 0.140507674725977 0.365588197799283 0.728416718695005 0.162207390348948 0.294648073587139 0.652324662738756 0.502325017803365 1.0 -0.220366679288972 0.3928153660318 0.155441939926546 0.483681332167866 -0.0649247393624258 0.800418814149132 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC097103.2 0.273608714136686 0.36602802370226 0.729053353040119 0.185231113787372 0.539578255936304 0.812783927483158 True False False False False False False 0 insufficient_or_context_specific +WDR11 0.153982574443196 0.366305435157632 0.729053353040119 0.303062665760539 0.0572538568258411 0.424455207563489 1.04847848730805 0.5770303769788989 2.0 -0.0218212240084128 0.955350480783537 -0.129686555800382 0.628183769250037 -0.151507779808794 0.602303973174657 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NIPSNAP1 -0.278461258681514 0.366457043277731 0.729053353040119 -0.53363921368131 0.0781406242729655 0.457322349441485 -0.540224115321616 0.182560032256214 0.845721396387966 0.0295674514595076 0.30549728106635 0.410471884840084 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDTC1 0.245232840243997 0.366523274566295 0.729053353040119 0.222912704425293 0.412571715674537 0.735302527699488 0.638570919621445 1.0 -0.821771722816144 0.0634127172436913 1.09522761709668 0.0136041348674141 0.273455894280536 0.497722343196104 reversed True False False False False False False 0 cross_species_direction_conflict +FAM120B 0.122682790890513 0.366641262446139 0.729053353040119 0.0899503662899897 0.503210624664754 0.792352484007396 0.314180860545862 1.0 -0.140646771493266 0.570591253420651 -0.338702791724765 0.0979699611555868 -0.479349563218032 0.0371806110676655 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ISPD -0.223971287506494 0.36670658254226 0.729053353040119 -0.0870833806698756 0.722364737751229 0.90145610631151 False False False False False False False 0 insufficient_or_context_specific +GFOD1 -0.24395304613359 0.366736304832542 0.729053353040119 -0.345880423978599 0.185929063502854 0.56775396895769 0.7255912519924599 1.0 -0.150886821594534 0.810610902599311 -0.369975645766067 0.404027256023033 -0.520862467360601 0.287754768720418 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DHRS3 -0.494355594969826 0.36732440267679 0.729567043961616 -1.20461308548319 0.0185672445333337 0.327267058068343 1.23381161394657 0.7664246751073108 2.0 0.0969698116879051 0.81310596327621 -0.417497264655315 0.165884557501829 -0.32052745296741 0.303832947347931 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP002884.1 0.238524466239689 0.367411036052814 0.729567043961616 0.269126885359846 0.309167676380693 0.662844357856409 True False False False False False False 0 insufficient_or_context_specific +EIF4E3 0.219640595186814 0.367424612313588 0.729567043961616 0.360340847889818 0.136663545672022 0.523136620282319 -0.556959662198206 0.160995392014859 0.0352755388752078 0.931269636795672 -0.521684123322998 0.157540978462748 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ACTR6 0.199371322057697 0.367601678741616 0.729674473426204 0.190608597540123 0.38897430332449 0.722009615770037 -0.202721905809156 0.669126502527531 -0.17733751490585 0.635267791397158 -0.380059420715006 0.33470763875269 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HELLS -0.274390867797626 0.367688640916099 0.729709900524845 -0.212241727089536 0.487093367856318 0.782147598778917 0.976059671025762 0.04027293591094 -1.48958437075642 0.0039566153281876 -0.513524699730663 0.280740350050998 reversed False False False False False False False 0 insufficient_or_context_specific +KIAA1755 0.450399048916531 0.368110764158612 0.730221691806275 0.584787705412623 0.239367457141114 0.606713331305531 1.44063411613222 0.0615877069562325 2.0 True False False False False False False 0 insufficient_or_context_specific +CTNNAL1 -0.299497927909984 0.368223175523452 0.730221691806275 -0.190734723631223 0.568174365279681 0.825129552905055 1.01014929781243 0.0278970866656539 -0.743019000876552 0.0539874564621374 0.267130296935875 0.535524038825641 reversed False False False False False False False 0 insufficient_or_context_specific +IDUA -0.347307411424027 0.368525422969496 0.730683833936514 -0.0349647432701721 0.932418728809654 0.981045440677165 0.28464172438263 0.443221884800799 -0.624745713436737 0.0537761425872147 -0.340103989054107 0.30994077618049 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCBP4 -0.327993581411109 0.369292810306168 0.731653877081275 0.0076404621422734 0.983236602678356 0.99451887511202 -0.0109531257620469 0.97167108654619 -0.664071208077559 0.0102391053289871 -0.675024333839606 0.0144283092262375 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TNFRSF25 0.507210056734485 0.369308076462203 0.731653877081275 0.469062286859105 0.405446411907887 0.733444811508554 -0.928737430722278 0.405614638279569 -1.57016586895148 0.175842401437588 -2.49890329967376 0.0470181113580401 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TUT4 0.15838968126894 0.369370174898809 0.731653877081275 0.224779033067567 0.195461882503419 0.571500015361699 -0.303179711021946 0.415487654984116 -0.495168388004473 0.123828264840496 -0.798348099026419 0.0307017236510469 partial_or_other True False False False False False False 0 cross_species_direction_conflict +Z84488.2 0.600166491812241 0.369479372961189 0.731653877081275 -0.401681372688548 0.547256141920101 0.815746201664891 False False False False False False False 0 insufficient_or_context_specific +FAM3C 0.282274025820542 0.369499760617291 0.731653877081275 0.457760250534546 0.135859796874915 0.523136620282319 1.16609156868333 1.0 -0.0935332680258939 0.753444349195425 0.207729488541645 0.343153419048799 0.114196220515751 0.646380343075643 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPS3 0.307319695034514 0.369655807270477 0.731671383469312 0.782263595041517 0.0200514519798444 0.332344160130608 0.296183905875435 1.0 True False False False False False False 0 insufficient_or_context_specific +USP24 0.178490679713175 0.369775996217536 0.731671383469312 0.341218950180551 0.0757052511292084 0.454145478080785 0.6063959886778061 1.0 -0.0596106655703403 0.852324370460469 -0.0726953903064481 0.760575555362796 -0.132306055876788 0.59141742610527 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRIM41 -0.326517550768441 0.369980084556874 0.731781516064346 -0.657221096186893 0.0641244735959142 0.433610060260339 -0.119978966640067 0.694008504879575 -0.448091166664097 0.0712450364394019 -0.568070133304164 0.0376398871801547 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL138828.1 0.317781858781524 0.370349816527673 0.732238457471755 0.271541500463136 0.442075387046816 0.758062305003835 True False False False False False False 0 insufficient_or_context_specific +REST -0.148998703837954 0.370707899275281 0.732497508332904 -0.12758883989748 0.446919656388498 0.761469121135878 0.111727717652723 0.775857602909843 -0.138492702623897 0.630564538561541 -0.0267649849711742 0.941142242357347 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC112206.2 -0.467668425200586 0.370720414623205 0.732497508332904 -0.699215074599727 0.169327595744008 0.549066571211682 False False False False False False False 0 insufficient_or_context_specific +VAT1L -0.706259988726452 0.370769270455563 0.732497508332904 -0.53620020983325 0.499868710059788 0.790772226672346 False False False False False False False 0 insufficient_or_context_specific +CAPNS1 -0.22219810112376 0.370878250002581 0.732497508332904 0.0937743495483227 0.713225721085301 0.895497343705388 0.468406479550964 0.494648730066494 2.0 -0.0117213212804596 0.968992221495458 0.350395418172245 0.0897018140309031 0.338674096891786 0.118941592988843 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNKSR3 -0.280541404447068 0.370955182956138 0.732497508332904 -0.19246909268703 0.535342096456106 0.811049969629352 -0.248027746735275 0.306828401090083 -0.0013559120949706 0.996161503721905 -0.249383658830246 0.258794864025058 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC007193.2 0.637107463209393 0.370966487692369 0.732497508332904 -0.344769805721841 0.596674238342944 0.841416670018005 False False False False False False False 0 insufficient_or_context_specific +C15ORF40 0.266471372080582 0.37124635354667 0.732516662081887 0.318160767444372 0.285760670998455 0.646864459864731 1.20673466647496 1.0 True False False False False False False 0 insufficient_or_context_specific +GATM -0.394453113684769 0.371253708922161 0.732516662081887 -0.128233242021342 0.773232470384925 0.921557797185125 0.156538356798249 0.784039873542692 0.121338553565134 0.775084435951439 0.277876910363383 0.544931979203416 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CREBZF 0.183136782213502 0.371481751778981 0.732692758319164 -0.180737546453484 0.370286576792575 0.709783165899783 -0.267859870190156 0.469181009611565 -1.07080221729862 0.0063649404045111 -1.33866208748878 0.003720919926498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAGT1 -0.180251949017245 0.371660444727218 0.732771423983188 -0.150356045142102 0.45421689636625 0.765695541335292 0.351237729303041 1.0 -0.177865682393109 0.591062660438741 0.0988301822619714 0.725860394817604 -0.0790355001311372 0.799661631189171 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL31 0.19065715911854 0.37208610761733 0.733336778835873 0.0977269265353279 0.65110105773092 0.86994747754025 0.278839405613566 1.0 True False False False False False False 0 insufficient_or_context_specific +YY1AP1 -0.129478349778767 0.372262416111943 0.733547329098525 -0.0370369571617363 0.803468930125635 0.931474264201915 False False False False False False False 0 insufficient_or_context_specific +ZNF677 0.361210590742082 0.372644780202148 0.733807847723331 -0.0906521362189057 0.811539471610591 0.933867437740013 False False False False False False False 0 insufficient_or_context_specific +RPS6KB1 0.147402953617656 0.372646722403229 0.733807847723331 0.0459569958823336 0.775547819656445 0.922202261508362 True False False False False False False 0 insufficient_or_context_specific +BCL2L14 -0.33284643724627 0.372722674896004 0.733807847723331 -0.0009281698072818 0.999206909553846 0.999585612191539 False False False False False False False 0 insufficient_or_context_specific +AMBP -0.261466560823662 0.372919079428865 0.734019321515651 -0.0606536586528053 0.836894588753036 0.947349959049485 -0.938899392299197 0.0717475183167114 0.710529975008644 0.125236535876845 -0.228369417290553 0.651280240515673 reversed False False False False False False False 0 insufficient_or_context_specific +RPL12 0.308552014645602 0.373069198886678 0.734177931378481 0.372527525262046 0.28195602195506 0.64323473576915 True False False False False False False 0 insufficient_or_context_specific +RPLP0 0.345754873674028 0.373381156327883 0.734381193835654 0.328426283852029 0.398863058129875 0.728959004281672 True False False False False False False 0 insufficient_or_context_specific +AAK1 0.130894671385355 0.373755069917197 0.734852182498295 0.181356175449993 0.212477790001106 0.585117503085987 -0.0565181198907558 0.915993062050496 -0.0667031368379551 0.868655413869666 -0.123221256728711 0.76982788492856 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ULK1 -0.298036603274745 0.373782095451147 0.734852182498295 -0.424842994824417 0.196015764227773 0.571700325195908 0.451091033098506 1.0 -0.426435572252138 0.125525121727138 0.171229038685702 0.484914273238182 -0.255206533566436 0.317856923814966 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIR181A1HG 0.30409359289843 0.373829425288724 0.734852182498295 0.784748495914143 0.0169737341597758 0.326204572615871 0.0337576538007324 1.0 True False False False False False False 0 insufficient_or_context_specific +KLC2 -0.331689484054051 0.374388079145089 0.735203486361493 -0.0851334619668028 0.832433731981567 0.944822630093409 0.326780840011287 1.0 0.0551167403650403 0.868066792119258 -0.962992806227772 0.0028841652686276 -0.907876065862731 0.005908929337261 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HECTD4 -0.11024288731186 0.37446730925396 0.735203486361493 -0.189375553365058 0.122271970399638 0.5038394341269 0.0735681725243443 0.859070568791721 -0.33688999032809 0.239891024691281 -0.263321817803746 0.395243172525044 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RCAN1 -0.305914254895789 0.374525639164677 0.735203486361493 -0.223854477180053 0.512573097000318 0.797722104677086 0.266453665041785 0.259602243528205 2.0 0.215291919753876 0.659599435197179 0.167725818827297 0.651069929968768 0.383017738581173 0.337867406261682 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNTROB -0.23877668087556 0.374672479180815 0.735203486361493 -0.274841982978441 0.307179524165917 0.661701213710167 0.7279422159359041 1.0 0.318110703637755 0.422258282577018 -0.886323587625612 0.0175801092683269 -0.568212883987857 0.131865448008291 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DTX3L 0.191472409573812 0.374742285601792 0.735203486361493 0.328402664677164 0.124295863610373 0.506294648147501 -0.189222810645258 0.607863110977287 0.538911313026097 0.0642484689546208 0.349688502380839 0.24887252230573 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RNF8 -0.169627698945326 0.374834786373705 0.735203486361493 -0.0874739780538657 0.645646315690465 0.867158605910181 -0.191991683611469 0.509021724549429 -0.565487171988255 0.0317575606778751 -0.757478855599724 0.0136652688720714 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VPS37B 0.260931330456186 0.374929996652155 0.735236052127314 0.0005560491665852 0.998481866340006 0.999257679999277 -0.191764300621798 0.610926060202046 -0.137564556238807 0.657251046345658 -0.329328856860605 0.30119526351377 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HAO2 -0.627353411327678 0.375159150269346 0.735412237011466 -0.999772827961331 0.146545258515248 0.532796338690088 False False False False False False False 0 insufficient_or_context_specific +AC073332.1 -0.286958172102183 0.37538719010853 0.73572265698271 -0.060580009257764 0.851315311866954 0.953856209560787 False False False False False False False 0 insufficient_or_context_specific +GPR137 -0.260093248465397 0.37565631853515 0.735995281042774 -0.106111673192918 0.716020681382917 0.897512329816079 0.389317399094942 0.3954731611982341 2.0 -0.160834604300869 0.634723797866651 -0.308806892190217 0.246424200100137 -0.469641496491087 0.10628174684105 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC007923.4 0.37053674274667 0.37571238858539 0.735995281042774 0.193024244260085 0.636111748333819 0.862000078223965 0.0415470960070494 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF600 0.309885802036029 0.37576218231718 0.735995281042774 0.329225518877144 0.349282460646391 0.694288655897113 True False False False False False False 0 insufficient_or_context_specific +MBNL1 0.186500296332768 0.375870186280956 0.735995281042774 0.0618475660851481 0.775949699665156 0.922368490099607 0.8998997143787671 0.095407704807035 2.0 -0.315577038581432 0.298882532308466 0.574824249772539 0.0392481988416559 0.259247211191107 0.342941862653947 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MOGAT3 -0.619897054424436 0.375907321383223 0.735995281042774 -0.695698241469044 0.313259110925033 0.665872698438998 False False False False False False False 0 insufficient_or_context_specific +TADA2A -0.184499093845838 0.375944549219898 0.735995281042774 0.0252087678581436 0.902935923155589 0.969313419082533 0.882999029881562 1.0 0.409185732749319 0.344536507202279 -0.981561177413432 0.0183923811354552 -0.572375444664113 0.168879378608484 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPX2 0.380132669261417 0.376207190463624 0.736243887023604 0.515012853467272 0.229892802978432 0.601091682478031 True False False False False False False 0 insufficient_or_context_specific +KTN1-AS1 -0.288193699127764 0.37621100307751 0.736243887023604 -0.118238831356275 0.720055650525927 0.899728961651734 False False False False False False False 0 insufficient_or_context_specific +TBC1D2 0.267561003890699 0.376295059460962 0.73627191211802 0.135009188513689 0.657385844598764 0.871691185476023 True False False False False False False 0 insufficient_or_context_specific +USP36 -0.248665681632175 0.376510453727454 0.736420409495083 -0.436587218081278 0.100697228170892 0.478255211438721 0.515857641440942 1.32336205743801 0.0708773935841159 3.0 0.196141945735367 0.48851729371843 -0.834685838132434 0.005309342657281 -0.638543892397067 0.0248540910536483 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ECHDC2 -0.362177162189937 0.376673279032081 0.736602422674702 -0.629286310660144 0.112887296906735 0.492341038791796 -1.62795425930905 0.0017847253128329 0.878078201353728 0.0287282815273659 -0.749876057955319 0.0586310372840311 reversed False False False False False False False 0 insufficient_or_context_specific +EI24 -0.248142195183561 0.376825780125005 0.736764182696259 0.161465727172704 0.563869047489735 0.823754286312897 -0.318611844087016 0.475354617612388 0.934068881813909 0.0211461330069029 0.615457037726893 0.113439502699312 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRPF38B -0.231673737468057 0.377034362297068 0.736881825751929 -0.402857692990079 0.114291270752539 0.492525402696043 -0.0805792134720425 0.833338945112215 -0.570001507798105 0.0506494681566356 -0.650580721270148 0.0371806110676655 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZDHHC7 -0.180790664540181 0.37709688093545 0.736881825751929 -0.290864473834447 0.155573063357484 0.539558215777 0.5896228302208161 1.04258500056957 2.0 0.108958638319222 0.765776941301431 -0.0291649712106076 0.925137577988307 0.079793667108614 0.803881669345041 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIL1 0.146364135600824 0.377337035987315 0.736881825751929 0.115086948969735 0.488070252761195 0.78289968530123 0.426529088998508 1.0 -0.502291119984224 0.0640499030414877 0.744506705367248 0.0080711229420501 0.242215585383024 0.31812376267788 reversed True False False False False False False 0 cross_species_direction_conflict +ZNF568 0.264613162793105 0.377338752066589 0.736881825751929 0.14805416781457 0.615875959310529 0.851916120639411 True False False False False False False 0 insufficient_or_context_specific +RBM28 -0.160442869459701 0.377455134259618 0.736881825751929 -0.0787827481680732 0.666139807500741 0.87511808324756 -0.0758929915805998 0.831512232858911 -0.375794649344952 0.144222495331125 -0.451687640925552 0.0995956133651801 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CSNK1D -0.162292992733106 0.3774651386587 0.736881825751929 -0.152778526749569 0.405971914989201 0.733444811508554 0.675772582703392 1.0 -0.0829908670263048 0.760341768020019 -0.158569089165166 0.439602111994184 -0.24155995619147 0.262405238542454 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF38 -0.130591371197183 0.377474907721308 0.736881825751929 -0.054221680747836 0.715014770988288 0.896996904954176 0.382685356904569 1.0 -0.179593920949121 0.567891592769273 -0.219226202796306 0.385848950412737 -0.398820123745427 0.14295871256334 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BCAP31 0.344873778385608 0.377514093151372 0.736881825751929 0.46775770018793 0.243357996751291 0.609898739043611 -0.114081701234306 0.699859313030867 0.372671165172475 0.111868720558131 0.258589463938169 0.284213165291042 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RELN -0.603515627876771 0.378002534722426 0.737426230894193 -0.271455194912865 0.693313134033744 0.88707143170732 -0.184645920740397 0.661360901406379 0.757428446584886 0.0367148149027129 0.57278252584449 0.10610738150025 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMC2 -0.406449537530527 0.378110326166992 0.737487048740799 -0.0131414759044324 0.975015818923247 0.992692094136128 0.974516031107833 0.0764717290859699 -0.729614245296207 0.0882570977883022 0.244901785811626 0.672367270763274 reversed False False False False False False False 0 insufficient_or_context_specific +TMEM237 0.432220023759343 0.378222299766534 0.737487048740799 -0.0241323082290868 0.960395762117938 0.988836580730567 0.512708428709868 1.0 0.814279685699959 0.0973692986395411 -0.140916105255609 0.720045502903935 0.67336358044435 0.144040532343639 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MEF2C-AS1 0.287320536735816 0.378348526820229 0.737487048740799 0.56045017330545 0.0882383733637299 0.468622105620855 0.150254729580219 1.0 True False False False False False False 0 insufficient_or_context_specific +DBNL -0.199525074881701 0.378382964863507 0.737487048740799 -0.185783457207251 0.411939621435227 0.735291083225579 1.73004822603971 1.0 -0.41480475810081 0.124844707436408 -0.254395306871255 0.283977037318444 -0.669200064972065 0.0202916966133046 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CRY1 0.386298790158444 0.379481500331055 0.738922618800748 -0.0042828160210492 0.99275448277621 0.998236115892821 0.265797762023905 1.0 -0.496224424496327 0.442217568831759 -0.309973392206118 0.578838088696565 -0.806197816702444 0.167611734682107 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBC1D8B 0.280721276008434 0.379485748280483 0.738922618800748 0.541266089059875 0.0919509963211973 0.472460751419842 0.0407616419148731 1.0 -0.0767064554198604 0.885312885080925 -0.0257157295465382 0.949547299972159 -0.102422184966399 0.81398381656773 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CIAO1 -0.223087553590762 0.379533267093632 0.738922618800748 -0.379340652893912 0.125581321899443 0.507996233320616 -0.188225505947877 0.602700999714043 0.270601333500264 0.341460810388599 0.0823758275523875 0.807847238569808 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZER1 -0.178299644693903 0.379625640811824 0.738922618800748 -0.228793634241968 0.254104479746954 0.619121653608424 0.0340856230020116 0.939953142486704 0.250670919444349 0.393503512221487 0.284756542446361 0.37105858519043 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLCE 0.221722914134676 0.379720443074146 0.738922618800748 0.355399172882111 0.155145767224466 0.539558215777 0.630126321851057 1.0 -0.607099701039818 0.218250507709268 0.909635202513192 0.036039717420527 0.302535501473373 0.487856877889904 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HHAT -0.328154564771718 0.379749396629367 0.738922618800748 -0.248382730535835 0.50737333321075 0.794310314103592 1.45015049724187 1.0 0.181622167450474 0.692046018169297 -1.17824219217749 0.0079719473086368 -0.996620024727016 0.0276308926867008 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR73 -0.142361615827946 0.379929604207271 0.738946890008695 -0.176563303034022 0.27420995949493 0.637623822254105 0.8064325016497191 1.0 0.276418670247841 0.492560827937107 -0.0872127538105884 0.791631921384899 0.189205916437253 0.608830294342881 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DENND2C 0.187781411234591 0.379971838023983 0.738946890008695 0.142777942892773 0.504529628040315 0.792758405693685 True False False False False False False 0 insufficient_or_context_specific +NOL4L -0.282631762405085 0.380437341536986 0.73929237790744 0.020372860812137 0.952152558463648 0.986925850408325 1.45167143380385 1.0 0.334639564233522 0.621966290618527 0.207113525062789 0.665122964155281 0.541753089296311 0.331319980641342 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MED12 -0.230553672601237 0.380499117279461 0.73929237790744 -0.177443257865288 0.497346467406326 0.789146979692815 -0.189575456202518 0.674997859030404 0.0803179453342825 0.828789416295883 -0.109257510868235 0.789935213186119 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIER3 -0.223808918658212 0.380559966445888 0.73929237790744 -0.136427402229718 0.596539208081492 0.841416670018005 -0.353161927045501 0.272469437509931 -0.223190953770823 0.423403832322288 -0.576352880816323 0.0642531401365592 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC02241 0.223043030300483 0.380624868218995 0.73929237790744 0.258466772642728 0.307874710806584 0.662243470533128 True False False False False False False 0 insufficient_or_context_specific +CXADR 0.416700653606664 0.381068965108179 0.73975836788485 0.249898676328542 0.598606279104206 0.842680747516785 -0.232156705332523 0.554902077918115 -0.129148760235661 0.700725230312914 -0.361305465568184 0.283682080171443 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AGL -0.216984747644958 0.381113692868145 0.73975836788485 -0.395134593303074 0.105501948201379 0.482830329046451 0.0226594629460741 0.954530635502806 -0.114409223421922 0.668468039731461 -0.091749760475848 0.768569918419171 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DGKQ -0.349567705558258 0.381128141155677 0.73975836788485 -0.381909191504422 0.33534010415123 0.684461073909613 -0.0171206762298141 0.970149088285888 -1.0672019858885 0.0071779305864204 -1.08432266211832 0.0100642273268408 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP2R5B -0.256475067782853 0.381222559477062 0.73975836788485 -0.150482521574466 0.613469450139834 0.850400399282578 -0.0090933090558358 0.98458409742132 -0.826085962017629 0.0211841485110617 -0.835179271073465 0.0278083645993672 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERMARD -0.175999892091402 0.381267890389645 0.73975836788485 -0.0251908046423705 0.901549399642699 0.968514302139562 0.322791301274128 1.0 False False False False False False False 0 insufficient_or_context_specific +RANBP3 -0.14902869622115 0.381299965715984 0.73975836788485 -0.211034743107439 0.209719007432802 0.581956585220706 -0.252878018577156 0.276048329933028 -0.132739033117923 0.516839669027724 -0.385617051695079 0.080586674882408 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL359232.1 0.326255288905661 0.382077634596445 0.740037658777702 0.247257545166348 0.510809770275607 0.796519013040946 0.0307743411473255 1.0 True False False False False False False 0 insufficient_or_context_specific +PARD3 -0.212187587036461 0.382112299964107 0.740037658777702 -0.108829943586987 0.655021944032478 0.871217143498979 0.353073770852638 0.6536006829637541 2.0 -0.320116509026016 0.175160281917622 -0.26599747613575 0.203948052958726 -0.586113985161766 0.0201349712657595 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SHE 0.335416425234194 0.38211575590553 0.740037658777702 0.185132336180577 0.630005675952285 0.85897526668397 -0.0074593149726643 0.98931579652119 0.597652509098851 0.0861479264918645 0.590193194126186 0.121603292560321 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LNX1 0.406740707862916 0.382132486781589 0.740037658777702 0.184170244328388 0.684471849225883 0.882914329154169 1.07411599175279 1.0 True False False False False False False 0 insufficient_or_context_specific +NDUFS4 0.178968787114199 0.382136190113028 0.740037658777702 0.161710134144358 0.42891030756157 0.748336221434264 -0.361602683958375 0.145358713769358 0.515037260991228 0.0291646235742549 0.153434577032853 0.508173835372346 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DHRS1 -0.372489013791016 0.3821450996817 0.740037658777702 0.125576151667858 0.770157885683111 0.920562318243211 -0.311247584753131 0.559961874912392 1.04748063967228 0.0275141481921254 0.736233054919147 0.109178115476783 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HES4 0.287541969713277 0.382150512330439 0.740037658777702 0.433374580356828 0.193873677546889 0.570967444223168 True False False False False False False 0 insufficient_or_context_specific +UNC13D -0.326088771449534 0.382176642878881 0.740037658777702 -0.567153284731838 0.126816326325079 0.508384607335028 1.92315756822897 0.052930380201887 -0.674602673345382 0.281061804546386 1.24855489488358 0.198863217646761 partial_or_other False False False False False False False 0 insufficient_or_context_specific +YME1L1 0.153250621689554 0.382180245989317 0.740037658777702 0.0970573773981723 0.581533252831081 0.83332444054994 -0.267482577468207 0.306828401090083 -0.0927514263061264 0.698271549630013 -0.360234003774334 0.135275628399412 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GYG1 -0.176729437951394 0.382267361463286 0.740037658777702 -0.256274906483143 0.208937920584588 0.581282362459045 1.46080507937609 1.0 False False False False False False False 0 insufficient_or_context_specific +CHEK2 -0.31079225183454 0.38231564887453 0.740037658777702 -0.250601419794441 0.481166657821304 0.78036214643277 1.24627153890477 0.0205106629224027 -1.65759791273956 0.0033613148639595 -0.411326373834791 0.452237645846634 reversed False False False False False False False 0 insufficient_or_context_specific +TCEAL1 0.275443860156413 0.382355126788441 0.740037658777702 -0.125990381430002 0.690772012509096 0.88580609997548 -1.10941738898431 0.0955619379061749 1.66903109067409 0.0070113353905549 0.559613701689783 0.279067388409847 reversed False False False False False False False 0 insufficient_or_context_specific +PABPN1 0.216332549881968 0.382500814950685 0.740079981568482 0.161313987039613 0.517146474938181 0.80047390153897 -0.207123438162109 0.604968023577395 -0.831592592519576 0.0226406830380431 -1.03871603068168 0.0119683206534433 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRR5-ARHGAP8 -0.305935457740402 0.382517186912219 0.740079981568482 -0.229640339194207 0.518397490264825 0.800840369846825 False False False False False False False 0 insufficient_or_context_specific +APOC3 0.35911301334627 0.382778502145997 0.740234345710621 0.961555467953873 0.0244934609340766 0.349408136686844 -0.640371957151147 0.300802682685867 1.39292103835295 0.0228022489686079 0.752549081201799 0.183128207011902 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ERP29 0.238287884208864 0.382807305131653 0.740234345710621 0.142943103131038 0.596612196154942 0.841416670018005 0.561766196704533 1.0 -0.199440998184174 0.538636281279204 -0.156456965648194 0.564856283878203 -0.355897963832369 0.202743070826249 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MT1E -0.350926366671041 0.382928452812965 0.740333016809977 -0.604888952165263 0.129913817741057 0.515262993129256 0.5664704391870171 1.0 False False False False False False False 0 insufficient_or_context_specific +STX12 0.169885163379711 0.383206681099538 0.740600133342206 0.0778000812731163 0.701332991646525 0.891163043182575 0.7885665955532241 0.272310659555941 2.0 -0.0128021891988738 0.968993547007747 0.0082353404858805 0.974423910121543 -0.0045668487129933 0.987346287125091 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MFSD12 -0.301725745176854 0.383329176309159 0.740600133342206 -0.316069921540224 0.359292471921527 0.702743593654591 0.352264796883399 0.291195909727862 -1.04497989537911 0.0048793464745672 -0.692715098495708 0.0429524963054729 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SAMD5 -0.27178431933151 0.383359504849272 0.740600133342206 -0.142446523182282 0.647617799601249 0.86855377695836 0.4090660697741401 1.0 0.920914361128406 0.0212177934030192 -0.900536783878127 0.0170013848556383 0.0203775772502788 0.961032840885516 reversed False False False False False False False 0 insufficient_or_context_specific +TRNT1 -0.154013978380939 0.383423085103753 0.740600133342206 -0.122364790766746 0.489413557232864 0.78407610007841 -0.0905167631890317 0.787647587732967 -0.124941166668389 0.617042764317073 -0.21545792985742 0.416629745247091 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AMBRA1 -0.0958068867646209 0.383520189292797 0.740600133342206 -0.124990517309448 0.250993457725761 0.617713036519484 0.929291948839715 1.0 -0.0386987148125185 0.890593902490592 0.19268563525051 0.313747192413583 0.153986920437991 0.456342821466359 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FKBP15 0.128529397746772 0.383557636779237 0.740600133342206 0.0504731870028447 0.732747157976998 0.904431845923655 -0.200722477650047 0.53707720836309 0.0008277940507732 0.997861089730202 -0.199894683599274 0.48225604220515 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC104170.1 -0.581938948914083 0.383889510060602 0.74110540267322 -0.760472170832468 0.251857088915847 0.618547340340987 False False False False False False False 0 insufficient_or_context_specific +SDCBP2-AS1 -0.175050581713432 0.384095449358876 0.741367413954482 -0.248262933403688 0.215194120642289 0.587852789707652 False False False False False False False 0 insufficient_or_context_specific +ZNF217 0.262104275111242 0.384270320225399 0.741569373229713 -0.149039983984445 0.615407596305168 0.851680875840866 False False False False False False False 0 insufficient_or_context_specific +BCL7C -0.169308448578702 0.384602306832948 0.741805621585671 0.0078254109447191 0.969014887139769 0.99145839504038 0.137249977558079 0.660616604299113 -0.65243790098842 0.0189900399289173 -0.51518792343034 0.060593595564402 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANAPC16 0.170499178407794 0.384603520795602 0.741805621585671 -0.0740078767558974 0.708337716957532 0.893638108503159 -0.183766709625624 0.573619496442142 0.121429019484734 0.656421353176508 -0.0623376901408902 0.843188603495081 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITSN1 -0.133683898417146 0.384696185746937 0.741848827235828 -0.236736883704905 0.123197952018426 0.504547702641792 0.173945998711466 0.5393010431430679 2.0 0.287222048726438 0.285116326918176 -0.466525430880968 0.0577080394056011 -0.17930338215453 0.473638342271737 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDE8A 0.153939317267297 0.385850649662529 0.743306969972875 0.101663648731126 0.56507394935298 0.823754286312897 0.389796335119617 1.0 -0.451523489174579 0.233710040860128 0.192785804330797 0.562792398005951 -0.258737684843782 0.459968669739374 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ASPH 0.171975872046113 0.385885140830019 0.743306969972875 0.4312889297679 0.0211601869537629 0.337626926464496 0.0624054768122971 0.0718148743930272 2.0 -0.340803039434085 0.249042944530405 -0.107462714549254 0.695187134487566 -0.448265753983339 0.105713188408518 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HDGF -0.243531678285989 0.386148499732874 0.743306969972875 -0.421968748275345 0.126674047903893 0.508384607335028 0.443434707373361 1.0 -0.0724000065709319 0.860104122968205 -0.528582741602088 0.0787889934497568 -0.60098274817302 0.0607086442084818 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHF10 0.205216629097603 0.386181983516107 0.743306969972875 -0.0727236972263306 0.748945327602207 0.910671976140056 0.0957322814973896 0.768351486311559 -0.309246843233387 0.197369827353113 -0.213514561735997 0.409824865936315 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APOL1 -0.306481425151276 0.386197777279685 0.743306969972875 -0.262922395304237 0.45925202715827 0.768428352256263 0.286151290150974 1.0 False False False False False False False 0 insufficient_or_context_specific +MTMR4 -0.200000026412869 0.386226751020192 0.743306969972875 -0.488494947799031 0.0224920112294404 0.346028040476539 0.26111570562557 0.49713397377697 2.0 -0.095038553021412 0.764723842807102 -0.151688670783218 0.530901637763315 -0.24672722380463 0.325295889811717 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FIGN 0.307374324937526 0.386653781489012 0.743586634783422 0.227664966224456 0.522549227658656 0.802717117069707 0.124627598577394 1.0 -0.271359250682415 0.501014527023721 0.0103425252937831 0.978440647116865 -0.261016725388632 0.461202828869396 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IGFBP2 -0.4946042467764 0.386769099109621 0.743591294181738 -0.718232160135993 0.191570849494685 0.570552915001293 -2.52434957668197 0.0019884554811956 1.92583590931097 0.0067430453835695 -0.598513667371007 0.298429127599082 reversed False False False False False False False 0 insufficient_or_context_specific +ADGRB3 0.348134366649609 0.387135945331544 0.743971843977147 0.447589182088182 0.260019655970567 0.622885940784012 0.225696127806925 0.0804019341654096 2.0 True False False False False False False 0 insufficient_or_context_specific +LINC01725 0.26131245073182 0.387206884432721 0.743972754475098 0.0220658549310162 0.943441839812717 0.984366565940656 0.528032042637349 1.0 True False False False False False False 0 insufficient_or_context_specific +POFUT1 -0.192951009527723 0.387405054901834 0.744218080359091 -0.286583804520062 0.177605900557943 0.560377630006132 0.0188962046702447 1.0 0.0613091118086837 0.8890677464436 -0.496737084556025 0.109054637497247 -0.435427972747341 0.182256195684698 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EGR1 -0.458636410414454 0.387729572013951 0.74467733544806 -0.600399781733361 0.261448490133266 0.624236354325422 0.6627749556005971 1.0 -1.42669722731997 0.274938206628656 0.778659828067463 0.497927880185292 -0.648037399252506 0.594461671378564 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NKD1 0.319641264695146 0.387860109550562 0.74467733544806 0.028796433543797 0.936728220806278 0.982574377153548 0.356271712735674 0.308730649030502 2.0 -0.253516060261109 0.34475600395944 0.314332109403315 0.175457238058124 0.0608160491422065 0.823276202435986 partial_or_other True False False False False False False 0 cross_species_direction_conflict +JADE1 0.291266461221511 0.387875998575958 0.74467733544806 -0.0985109011555379 0.770116897169606 0.920562318243211 0.913988372924004 0.6202375937145029 0.0526907156132927 3.0 0.123222468997126 0.653980268706307 -0.338187007482566 0.121201157852252 -0.21496453848544 0.347086572430497 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MPP3 0.209436569594543 0.387959337309241 0.74467733544806 0.166554493834496 0.493943666332154 0.786363265568912 True False False False False False False 0 insufficient_or_context_specific +CYTH1 -0.205149006730834 0.388108405615407 0.74475618802026 -0.174045474192511 0.465986201475359 0.771256747133237 0.615838459635496 0.317494689006162 2.0 -0.1857005851868 0.533138911232709 -0.0061983741127561 0.982982101823982 -0.191898959299556 0.459408876272026 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CFLAR 0.183012037694825 0.3881913903328 0.744780065261439 -0.136200205440221 0.49791097011717 0.789518614144207 0.180544344855851 1.08690812440996 2.0 0.0274369145828809 0.948056065676743 -0.283443965494296 0.311896044417269 -0.256007050911415 0.388810272428763 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MEG3 -0.236376750123498 0.388429912033594 0.745002320850711 -0.47721110095113 0.0588124632709788 0.427941109491281 False False False False False False False 0 insufficient_or_context_specific +PPP2R3A 0.205723580057074 0.388478268945751 0.745002320850711 0.184333078860926 0.440786065988716 0.757156057136665 -0.274287206314845 0.564274375022974 0.339493087517277 0.361464174757941 0.0652058812024327 0.889200231367768 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM118B -0.212306050701031 0.388518922012125 0.745002320850711 0.119287925060335 0.615106217998472 0.851375386684303 0.135770026270844 0.769772313931098 -0.320757342630962 0.330649040628405 -0.184987316360118 0.638742355600932 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DYNC1I2 0.134384221060683 0.388693172415385 0.74509419503979 0.127888429785252 0.410795784408617 0.735240191860684 -0.257686602260589 0.352371028537476 0.228998590936972 0.329159952317744 -0.0286880113236168 0.922437762688832 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BLOC1S5-TXNDC5 0.306837099205623 0.388842625176736 0.74509419503979 0.273533349625198 0.446252248975383 0.761152058914717 True False False False False False False 0 insufficient_or_context_specific +KCNMB3 -0.209979909059719 0.389125983223291 0.74509419503979 -0.475501640449859 0.04215674487478 0.3908928278867 False False False False False False False 0 insufficient_or_context_specific +TRNAU1AP -0.152314084856643 0.389156013017973 0.74509419503979 0.0371206718740031 0.832981826812989 0.94503174627857 0.640970174319802 1.0 -0.0756802088922385 0.860499407994346 -0.0642306994046549 0.845283881796171 -0.139910908296893 0.683169836203475 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTTNBP2 0.385236914083877 0.38940161881405 0.74509419503979 -0.212430874561618 0.647894550082249 0.86855377695836 -0.887659808192896 0.138642121089436 -0.148696112097584 0.79849801867907 -1.03635592029048 0.0751678250571117 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SKA2 -0.253841104464778 0.389431431158988 0.74509419503979 -0.355335104556111 0.225954039465519 0.598493814456385 0.412056660157699 1.0 1.00721938615235 0.0919694373153687 -1.15829541866757 0.0318907698878728 -0.151076032515216 0.818111361987223 reversed False False False False False False False 0 insufficient_or_context_specific +XYLB -0.296144313515055 0.389444903183938 0.74509419503979 -0.247930870834665 0.472374273387036 0.775593712997022 0.5239467750337079 1.0 -0.79435344143989 0.0319353708538211 0.889571007773428 0.013876209066282 0.0952175663335382 0.791027022121956 reversed False False False False False False False 0 insufficient_or_context_specific +HSPH1 0.491476346163741 0.389476971194178 0.74509419503979 0.61441122522074 0.284202601777553 0.645043543745796 -0.0727220167316797 0.899324836501662 0.20070794602245 0.61747648368577 0.12798592929077 0.779807062401457 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DACT3-AS1 -0.460806016393716 0.389519358090705 0.74509419503979 0.200681931046367 0.720809110511243 0.900307889362085 0.6216811250983051 1.0 False False False False False False False 0 insufficient_or_context_specific +LINC00271 0.265464408723536 0.389551734243063 0.74509419503979 -0.133566162559253 0.65835058846238 0.871691185476023 False False False False False False False 0 insufficient_or_context_specific +SLC9A3R2 -0.242436624638106 0.389587292273512 0.74509419503979 -0.100557777409927 0.728659396428114 0.904012808833088 0.386671308123942 1.0 -0.269921382167681 0.385133212820665 0.451481640089481 0.0973025259289476 0.1815602579218 0.526350390611337 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTNNBIP1 -0.216454338451428 0.389625407351268 0.74509419503979 -0.291055562468092 0.239556999525288 0.606713331305531 0.27565256251006 0.282085655095727 2.0 0.0959322493746227 0.799430757596096 -0.312290622425686 0.24440272578641 -0.216358373051064 0.468358701141154 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GULP1 0.256275198517841 0.389739418116821 0.745177250358093 0.265005030134677 0.374185998762893 0.712471735786948 -0.0449277411015012 0.948978490920634 -0.24499059393585 0.598580409001527 -0.289918335037351 0.578548016607396 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPS6KA6 -0.412905753112164 0.389967191692567 0.745477749391657 -0.409317805262139 0.394541532221599 0.726080478554543 False False False False False False False 0 insufficient_or_context_specific +GPD2 0.179172536424317 0.390477366796266 0.745767047882111 0.270864549963767 0.189895041591164 0.569886897607216 -0.305321230719176 0.500954256970523 0.725358149880839 0.0475244209234306 0.420036919161663 0.2654898395993 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ADAMTS7 -0.459241937241402 0.390497803236022 0.745767047882111 -0.448737231594785 0.40240172074222 0.731374998725488 0.105118838310432 0.857861476753285 -1.22409730526917 0.0125798885888128 -1.11897846695874 0.0290078728286427 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CROCC -0.16196588457091 0.390570883485339 0.745767047882111 -0.287760086220473 0.115983618306549 0.494328725999491 -0.0117648410901596 0.983939963238723 -0.827608294940818 0.0496076527904639 -0.839373136030977 0.0662048066989493 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIP4 -0.137431144207153 0.390592576825869 0.745767047882111 -0.184835239208339 0.242786292410244 0.609516411139337 -0.470351167336078 0.0723788904168593 0.217708668507409 0.336238944439673 -0.25264249882867 0.28948953379064 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF28 -0.28975629818607 0.390723472129109 0.745767047882111 -0.133542871490901 0.696203202793615 0.888447116319334 False False False False False False False 0 insufficient_or_context_specific +GADD45G -0.553162771286578 0.390939294044974 0.745767047882111 -0.456421161509612 0.483611584368786 0.780666906162311 -1.99386653926908 0.0310071580014565 1.0942332646388 0.163281795671432 -0.899633274630278 0.254716471315757 reversed False False False False False False False 0 insufficient_or_context_specific +DCBLD1 0.222457855680277 0.390974136536253 0.745767047882111 0.429573124978165 0.0960123001133999 0.47569521889622 -0.283074251784486 0.538493466925763 0.689489514202865 0.0615875837383774 0.406415262418379 0.287754768720418 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GNAQ 0.192306171797783 0.391091619662233 0.745767047882111 0.301382182168779 0.173136516431985 0.554336007536445 -0.39952447093584 0.144758034685512 -0.209930133662772 0.384470154118706 -0.609454604598612 0.0298248636211815 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GRIP1 -0.582921830003552 0.391107580435027 0.745767047882111 -0.540687504982247 0.42977348628901 0.74852333689201 False False False False False False False 0 insufficient_or_context_specific +NTRK3 -0.647083739096878 0.391211706964669 0.745767047882111 -1.48546524543491 0.039032468382849 0.379484931484566 2.57828455416185 0.0053300212490504 -1.96247364574344 0.0084190829244678 0.615810908418415 0.466566447534186 reversed False False False False False False False 0 insufficient_or_context_specific +AC010735.2 -0.359264675345896 0.391237315980313 0.745767047882111 -0.769448184890927 0.0600314971946523 0.428702672545977 False False False False False False False 0 insufficient_or_context_specific +CCNDBP1 0.30275664535359 0.391436040391097 0.745767047882111 0.220948665306523 0.526549690531484 0.804819865166353 0.683458410625156 1.0 -0.236347954463478 0.400891405079156 0.0887313687733079 0.720045502903935 -0.14761658569017 0.571579189351074 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HIF1A 0.227612823584062 0.391468887551681 0.745767047882111 0.18807529139765 0.480442077684016 0.780346070738476 0.070395993277746 1.0 -0.178350415998508 0.760551622069903 -0.254599179493476 0.56101181686048 -0.432949595491984 0.356510521202702 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CDK9 -0.28322770170615 0.391517526365852 0.745767047882111 -0.399609500552208 0.219654108367486 0.592069212484543 0.0535558006429844 0.866857060038156 -0.362219632836838 0.111123872395074 -0.308663832193854 0.192133427834068 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC010809.1 -0.338704331516362 0.391517794981147 0.745767047882111 0.0147167506322133 0.974330228345738 0.992472605004756 False False False False False False False 0 insufficient_or_context_specific +AVL9 0.141390967199462 0.391543998158391 0.745767047882111 0.123067202466317 0.456373657632718 0.767060408474954 -0.226603786747921 0.52206945977619 -0.270765310237125 0.348766336620123 -0.497369096985046 0.113369157410473 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MYO6 -0.149973846096996 0.391961332823765 0.745991721961924 -0.0106402751681196 0.951080210989664 0.986917609553614 -0.394569065749163 0.113128979502674 0.308231659631581 0.158216582240089 -0.0863374061175824 0.728237411702902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL23 0.235538309123743 0.392015832290465 0.745991721961924 0.278759650903616 0.309552938525832 0.662858728430055 0.356538759445795 1.0 -0.247509402227965 0.583474222809846 -0.243487713474984 0.500956200302785 -0.490997115702949 0.204753649192168 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC087463.1 0.437862159646168 0.392397101865163 0.74624543069242 0.506593490536898 0.325430729646617 0.674724889947951 True False False False False False False 0 insufficient_or_context_specific +LHPP -0.261090642363847 0.392418510248562 0.74624543069242 -0.246674519264246 0.419446602058902 0.741298497579158 0.767934099981116 1.0 -1.86804594365674 0.0071564378163585 1.5817381639796 0.0113353783645509 -0.286307779677138 0.591296804217943 reversed False False False False False False False 0 insufficient_or_context_specific +MIRLET7BHG -0.240051396565675 0.392665897326509 0.746296652322175 -0.172167724803907 0.547048583849312 0.815603096463177 0.770344858130672 0.5458693717987371 0.140543678295797 3.0 False False False False False False False 0 insufficient_or_context_specific +NCEH1 0.292354208291611 0.392692249319591 0.746296652322175 0.312757512685423 0.361087724578878 0.703177809506737 -0.0769048255418775 0.917945009132389 0.77746034126131 0.0939992917402572 0.700555515719432 0.16765676831985 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RHBDL2 -0.232020310036218 0.392946181452098 0.746296652322175 -0.381532268507109 0.1428359988192 0.528588319499865 False False False False False False False 0 insufficient_or_context_specific +DNTTIP1 -0.267345658681016 0.393102867472239 0.746296652322175 0.123551131024432 0.708100525494551 0.893638108503159 1.21454353427083 1.0 0.184415865127697 0.517999474047107 -0.279255782543687 0.22251450486656 -0.0948399174159898 0.725831244745298 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC92 -0.174566736601205 0.393111261786483 0.746296652322175 0.134871336654721 0.530395510901343 0.807486056827164 -0.179268775007725 0.856375858040323 0.255131604328671 0.695608897198272 0.0758628293209463 0.927489221408977 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF4 -0.134070236632184 0.393224432253055 0.746296652322175 -0.200445139036025 0.191758160677382 0.570665777497258 -0.128586815672702 0.612055771718481 0.132458050635381 0.518512489916839 0.0038712349626796 0.988038906303874 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHKA1 -0.394322563531706 0.393242794333762 0.746296652322175 -0.580207558848637 0.199756029140791 0.575263953748573 0.178184925120891 0.580906900835266 -0.601595203428304 0.0317341659171827 -0.423410278307414 0.135275628399412 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHF12 -0.152211748241629 0.393257398169624 0.746296652322175 -0.0682856276371175 0.713105945909432 0.895497343705388 0.372206496224681 0.273770447792664 2.0 -0.279654456733692 0.269333114304813 -0.217815310304565 0.324736336718888 -0.497469767038257 0.0451444777314344 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HLA-DPB1 -0.362061812260548 0.393290211755163 0.746296652322175 -0.23281487325878 0.587026871084578 0.835274227991216 False False False False False False False 0 insufficient_or_context_specific +MZT2A -0.249598899524611 0.393416944616728 0.746296652322175 -0.0607679627799384 0.838940332253485 0.948242375327298 False False False False False False False 0 insufficient_or_context_specific +ZNF106 0.159376476968787 0.393425180639901 0.746296652322175 0.0747081682334909 0.687410155371024 0.884451344908836 0.480726736012331 0.0974175625021959 2.0 True False False False False False False 0 insufficient_or_context_specific +EIF2AK4 -0.139823903024745 0.393438410586881 0.746296652322175 0.0440498786674143 0.788616855181482 0.926576536501901 0.446665043800202 1.0 0.552331206714167 0.0973715788036731 -0.660871508844757 0.0322730862911399 -0.10854030213059 0.752620211258687 reversed False False False False False False False 0 insufficient_or_context_specific +PPP1R12A 0.168953305805196 0.393450613359213 0.746296652322175 0.0459704052052995 0.819575855235218 0.937645994477492 -0.0170160031259706 0.9601987190862 -0.181516903861529 0.435694026991303 -0.1985329069875 0.420542301163057 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CDK11B -0.182331908565829 0.393499757091568 0.746296652322175 -0.283056028079624 0.180361412304578 0.563389287311165 -0.218216183117522 0.4904443884683 -0.400481957760346 0.1334069625157 -0.618698140877869 0.0391192924005971 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMC5 0.158813985435494 0.393505726792721 0.746296652322175 0.0780080000608979 0.675188294955732 0.878580824298291 0.0951292026981025 1.0 -0.158280059943237 0.599714475679788 -0.189689409671676 0.435880216928654 -0.347969469614913 0.175731906315342 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF224 0.190060743767101 0.393749273706674 0.746444745461522 0.350484281487444 0.119268520285335 0.499900248662619 0.0290504591574018 1.0 True False False False False False False 0 insufficient_or_context_specific +C1RL 0.129492828925704 0.393756810358714 0.746444745461522 -0.054453189495861 0.727813895049352 0.903711525806311 -1.10005077622931 0.0117937483379435 1.03741448712312 0.0118274392668437 -0.0626362891061914 0.882160573064927 reversed False False False False False False False 0 insufficient_or_context_specific +INPP5D -0.347498190547309 0.393832162371343 0.746444745461522 -0.467722298006749 0.244687853914839 0.610669341516615 0.616571437525147 0.177235963854824 -0.633809898263717 0.0912632109825349 -0.0172384607385699 0.974700350418372 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARAP3 0.246254896820772 0.394011046392056 0.746535081414728 0.253288088792554 0.380994755112893 0.7172864879604 -0.286632730019268 0.382879533187396 -0.696674238039061 0.0266934064077403 -0.983306968058328 0.0085974855976623 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ABCA5 -0.222971706563994 0.39422961871201 0.746535081414728 -0.415992507642582 0.0992410205491628 0.478125555523304 0.769466708487666 1.0 0.669420384260885 0.339783213151304 -0.930307081865192 0.102234291175216 -0.260886697604308 0.729288723051541 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TPMT -0.365036729655017 0.394258146350427 0.746535081414728 -0.439460710618544 0.300797426250185 0.658632920234719 -0.747858650363078 0.0326237979384006 0.992804065500937 0.0059324002168397 0.244945415137859 0.418178582365966 reversed False False False False False False False 0 insufficient_or_context_specific +VHL 0.275112548379803 0.394267817197246 0.746535081414728 0.0943152918290748 0.768026025859891 0.919680025068473 -0.0964129867531128 0.844237898439064 0.113790845321665 0.746819243489507 0.0173778585685517 0.968445908101088 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SF1 0.156525472073814 0.394526139749226 0.746855496047427 0.0662936826557539 0.717794356493638 0.898496799968868 0.437774697804415 0.110306878617056 0.0775415020035941 3.0 -0.471988850899184 0.34341928484378 0.207450076795603 0.626089978157807 -0.264538774103581 0.567117869475732 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PITPNM3 -0.527288876612964 0.394578514581602 0.746855496047427 -0.856704526210555 0.149103243321019 0.533583468169136 False False False False False False False 0 insufficient_or_context_specific +PHYHD1 -0.289441735920607 0.394743520309957 0.747033892710616 -0.488814827847722 0.150000385328544 0.533583468169136 -0.448323039503917 0.127252575967881 0.0945134979457597 0.731048442199506 -0.353809541558157 0.192780626196007 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EVI5L -0.199634400318522 0.394895629779199 0.747187824230965 -0.278583364160794 0.238826518556275 0.606415397271769 0.3524898427211871 1.0 -0.0752551237654933 0.845155842907057 -0.629177706091937 0.0335484455130118 -0.70443282985743 0.0297616020955191 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDIT4 0.783667375677489 0.395029971787105 0.747238036065908 0.503919881979028 0.576186076809184 0.829928048970172 0.356333430022697 0.324242633556903 0.0366480729828944 3.0 -1.02243853673495 0.170205026279358 1.13684488193988 0.0870638706644835 0.114406345204927 0.882674458570547 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PKN2 0.115412001281292 0.395176219586872 0.747247448872954 0.133813658363243 0.321341877184749 0.672472248121257 -0.193721231836668 0.499189494664168 0.0457305527270443 0.863516697635107 -0.147990679109624 0.567188206552526 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CXXC1 -0.322336361404373 0.395210243844154 0.747247448872954 -0.180084764646351 0.640023239882082 0.864640237429136 -0.197983532665605 0.493950985254097 -0.282624994776457 0.238306783981868 -0.480608527442062 0.0689879400066484 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPA1 -0.239157712600715 0.395802510311379 0.747820527895888 -0.267131502802095 0.342157818097122 0.689130402583821 -0.473749625170493 0.166068813766625 0.666503056856291 0.0386019497383689 0.192753431685798 0.551999714551262 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL160272.2 0.382524015644299 0.395867487252332 0.747820527895888 0.311733040899623 0.490842357843305 0.785318020019641 True False False False False False False 0 insufficient_or_context_specific +KCTD6 -0.239243204100506 0.395944647695751 0.747832484860776 -0.12643480050159 0.656232468527311 0.871684912617742 0.253896337905519 1.0 -0.152868230656829 0.647594429760889 0.575491761202563 0.0337895114357347 0.422623530545735 0.123424164716953 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALPK2 0.495613903230559 0.396268937651634 0.74817729680364 0.304722177453657 0.592743933321235 0.838902274600198 True False False False False False False 0 insufficient_or_context_specific +GAS2L3 -0.285990307748367 0.396506969767946 0.748492863724293 0.433226636415722 0.20091611140259 0.575963156173919 0.510180745141818 1.0 3.13730364700051 0.002507928178991 -2.52593627667376 0.0025566583313803 0.611367370326746 0.572035909069644 reversed False False False False False False False 0 insufficient_or_context_specific +BORCS7-ASMT -0.286656190027669 0.396672831718463 0.748672105342068 -0.655603025937671 0.0536705928269837 0.417523375612427 False False False False False False False 0 insufficient_or_context_specific +MSC-AS1 0.283112405140097 0.397032743472467 0.74908357855295 0.511458735583794 0.114814828112225 0.492613299848511 1.26596350413696 0.131685176025008 0.109878775041888 3.0 True False False False False False False 0 insufficient_or_context_specific +IDH2 -0.168573950300119 0.397623555431794 0.749796302598479 -0.139816310874518 0.480162456971224 0.780171625223481 0.5744193579596559 0.0424702228308104 2.0 -0.118429255904765 0.684990529144695 0.338328273320384 0.139128552767391 0.219899017415619 0.356515718311367 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCHCR1 -0.360503172358073 0.397850068345961 0.750089468142261 -0.785525785220821 0.0424501361403098 0.39108947414432 0.3769635536339129 1.0 0.179666669801698 0.751194800228106 -1.65180296598389 0.0044747561098456 -1.4721362961822 0.0129827441554019 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATF6 0.156730276119817 0.398049365506511 0.7502793993673 0.125013850531072 0.500654294918762 0.790819493321426 0.862302764665891 1.0 -0.241936505133878 0.41730467354195 0.166268407259611 0.510530095524966 -0.0756680978742668 0.797207995660069 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GDA 0.519783078237798 0.398138510261619 0.7502793993673 0.471468570392591 0.4445459351599 0.759994423711047 -0.12300677059189 0.861352113077705 -0.38479170589902 0.428801094481964 -0.50779847649091 0.339137138492324 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IRAK1BP1 -0.210242957781369 0.398262847052384 0.7502793993673 0.0623313725643322 0.806275653482916 0.932788199072101 -0.240725474582255 0.708254843551781 0.344151490705721 0.450305439532251 0.103426016123466 0.859101658571639 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC008554.1 -0.469696810792393 0.398295584726383 0.7502793993673 -0.42266382766909 0.449829535496899 0.763939182518913 False False False False False False False 0 insufficient_or_context_specific +PAIP2B 0.386504654515817 0.39830612175163 0.7502793993673 0.59959338193628 0.196798192481319 0.571879675616801 0.35021670735578 0.0138581650442262 2.0 -0.457481565636629 0.13986660719519 0.389248771431327 0.142688750273669 -0.0682327942053024 0.828995152440669 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NMRK1 0.292197023777295 0.398587527032329 0.750584925468433 -0.0137386682959978 0.968255613617031 0.991065707083724 -0.18307243127741 0.705726107349112 -0.273779037096452 0.462492973557839 -0.456851468373862 0.254773112449076 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDK3 -0.273933795524189 0.398688229803865 0.750584925468433 -0.4982356867966 0.116067523371163 0.494328725999491 False False False False False False False 0 insufficient_or_context_specific +CEP162 0.17995010046086 0.398811840601983 0.750584925468433 0.337223806797795 0.103700433189166 0.479932265033934 -0.148951842420664 0.856375858040323 -0.347771451723231 0.540133416542516 -0.496723294143894 0.425570285641061 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DCUN1D2 -0.145872838877881 0.39892268318415 0.750637264134424 -0.0133531578406838 0.941328436984294 0.984111856389759 0.880547094302322 0.107707006719275 -0.417535591284202 0.32329539358183 0.463011503018121 0.372504355525603 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BHMT2 -0.507674605571034 0.398996169360129 0.750641759819002 -0.70930592709274 0.235870303724661 0.604926482992162 -0.577435927781408 0.141360339207799 0.936367440218291 0.0170496156421136 0.358931512436883 0.315557932272326 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF136 -0.201493458411431 0.399078568952424 0.750663019953624 -0.0941938275349631 0.701910728425977 0.891472626689863 0.7474435483577959 1.0 False False False False False False False 0 insufficient_or_context_specific +USP46 0.203566186009244 0.399305173603593 0.750955472551966 0.322800298093108 0.178759946271656 0.561710569266709 -0.02731008263704 0.953076893194323 -0.247453582318302 0.414520184003729 -0.274763664955342 0.410837234404534 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MKLN1 0.179296915791156 0.399496492105203 0.751102239513525 -0.0011098259129209 0.995872876104847 0.998795540446485 0.558948841980323 1.0 -0.0656436425862181 0.822911808441052 -0.0858569603058724 0.698243579301301 -0.15150060289209 0.503376869575852 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRP11 0.282873813465304 0.39952549508505 0.751102239513525 0.662128849726076 0.0662009892590666 0.436071024157137 0.036635040118312 1.0 True False False False False False False 0 insufficient_or_context_specific +VAMP4 0.283994625695763 0.399621837030352 0.751149609287246 0.13464917925381 0.689258581399276 0.884999569552245 -0.226702276022773 0.427896022950611 -0.0504364927738751 0.849670302511415 -0.277138768796648 0.27523900203241 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FERMT1 0.435834964895701 0.400371707838147 0.75229124245509 0.565988549687941 0.278232612449727 0.64163031117834 0.887719232504079 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF280C 0.309307072799847 0.400560579803683 0.75237833153661 0.221315523170379 0.545697001387674 0.815494542201141 True False False False False False False 0 insufficient_or_context_specific +TRIM8 0.173252204418801 0.40087664167532 0.752704176206301 0.0666694231261274 0.72901178679445 0.904012808833088 0.248776574400935 0.9125563539441759 2.0 -0.0861750452856703 0.777993416002732 0.0251592556183353 0.924920664222024 -0.061015789667335 0.820795203351876 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SNHG7 0.250655449279151 0.401159310705659 0.752967111543172 0.347115291807941 0.246522433029665 0.611559754402286 0.0143346165151649 1.0 True False False False False False False 0 insufficient_or_context_specific +ATF3 0.538470524394437 0.401352343993216 0.753098036882029 0.172538246738585 0.791114605003047 0.927588847807277 0.0352010318753275 0.312434595711372 2.0 -0.921255459262826 0.23586333119608 -0.729403644302596 0.322154288832473 -1.65065910356542 0.0432331602273753 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ATP5IF1 0.331855961930929 0.401395995616083 0.753098036882029 0.349858086030705 0.378462120212146 0.715708949525317 0.400955286726979 0.0206010644669032 2.0 True False False False False False False 0 insufficient_or_context_specific +AMN1 0.24038156313427 0.401548793636981 0.753098036882029 -0.0026996104843851 0.992395127629788 0.998236115892821 0.329828101823771 1.0 -0.139335241712937 0.685343728858611 -0.352295775077351 0.186254483670727 -0.491631016790289 0.0931909208104023 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OGDH -0.144267763179464 0.401638696145888 0.753098036882029 -0.31075725688154 0.063854918123822 0.432999502601999 0.265605676122786 1.0 -0.176974215719299 0.642781738449557 0.58564457667031 0.0631027379832014 0.408670360951011 0.196286811450474 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DSE 0.296098922982353 0.401657041644507 0.753098036882029 -0.333602250639081 0.376535249207846 0.714064764642842 0.701641845129326 1.0 0.280745609382323 0.376559109740027 -0.158712086958385 0.562792398005951 0.122033522423938 0.692055477154099 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPM2A -0.257820222692814 0.401969616735057 0.753131586691641 -0.169351078175933 0.584627209420462 0.83427397074951 1.13474621441796 1.0 -0.444188536777801 0.565501410926621 0.672518241112812 0.220692926188544 0.22832970433501 0.732755111122619 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRSF8 0.379305291708356 0.402022407626253 0.753131586691641 0.0136242625896275 0.972496448168449 0.992040338141303 True False False False False False False 0 insufficient_or_context_specific +DYRK2 0.304409135850337 0.402027884412668 0.753131586691641 0.656464575849216 0.0638351534114337 0.432999502601999 0.648385637477639 0.0255699939632015 2.0 -0.0337136582224965 0.949033587947504 0.127931662410511 0.727144738213204 0.0942180041880144 0.820974160188223 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DLGAP1-AS1 0.395487051110139 0.402076326865527 0.753131586691641 0.355205253504504 0.450149061778757 0.763947905803589 True False False False False False False 0 insufficient_or_context_specific +FCGRT -0.238388319341375 0.402088282610846 0.753131586691641 -0.362805621927302 0.200437980099844 0.575559158741573 -0.0613123186349738 0.897356985172915 0.367305396417246 0.259825333612605 0.305993077782272 0.372951020898835 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBA6 -0.164647476214758 0.402153343425267 0.753131586691641 -0.0596415614010448 0.762124320914271 0.916563228182353 -0.168373139056347 0.745995021322483 -0.200746961480583 0.604775116706659 -0.36912010053693 0.379631111318528 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MBOAT1 -0.218361177977785 0.402178427680928 0.753131586691641 -0.0670221812649695 0.799925065838542 0.929755328734014 0.5089440889849771 1.0 False False False False False False False 0 insufficient_or_context_specific +SNAPC1 0.174956064207792 0.40224559740047 0.753131586691641 -0.027860378549069 0.896699153391879 0.967531580672392 -0.296497233387252 0.587960988575737 -0.0331791106608594 0.947092967064115 -0.329676344048111 0.486005805191548 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PGM2 -0.252063594211396 0.402438975115055 0.753277693664303 -0.364489761427625 0.22599791743025 0.598493814456385 0.26320242993831 1.0 0.371265656083139 0.300161201299016 -0.384437813472652 0.199650902679566 -0.0131721573895128 0.974165225485231 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AHR -0.463741204343259 0.402584653060341 0.753277693664303 -0.679316956613674 0.221317618828838 0.592913326464062 0.601315987867561 1.0 -0.604459304627475 0.0865395341878574 0.330128488652002 0.277006458736062 -0.274330815975474 0.394050200447444 reversed False False False False False False False 0 insufficient_or_context_specific +PPP2R5D -0.221039639253371 0.402609019260055 0.753277693664303 -0.111241081614226 0.675284498200678 0.878580824298291 0.346758192304031 0.328001147353056 0.174927786994083 0.555142785786831 0.521685979298114 0.11004020042208 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC108866.1 0.202715231562491 0.402691234786831 0.753298025669624 0.518746627666283 0.0313074210363433 0.375031405408838 True False False False False False False 0 insufficient_or_context_specific +CALN1 0.384956922847842 0.402964217371923 0.753433688873013 -0.616631182950763 0.0776953407870781 0.456995770490234 -0.959416258156411 0.221568587229871 -0.0481905402128473 0.952898851001448 -1.00760679836926 0.168879378608484 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STX8 -0.108936504479963 0.403084684729668 0.753433688873013 -0.137562245641 0.286208906365786 0.64687121300967 -0.223468843004445 0.462671117993825 -0.307437044857926 0.226317057508911 -0.530905887862372 0.0604551190265147 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MGRN1 -0.173680686383807 0.403191609710952 0.753433688873013 -0.411223784312817 0.0461149474344625 0.398473305589448 -0.0546983975692951 0.844356614344803 0.0378612347379496 0.864694784658741 -0.0168371628313455 0.943926318397945 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF765 0.201033279582452 0.403191924808915 0.753433688873013 0.254941480967817 0.284373328666687 0.645264045575518 True False False False False False False 0 insufficient_or_context_specific +PCDH9-AS2 0.375887867533153 0.403460135815634 0.753668102254328 0.431946360877651 0.340964752421671 0.688566111304456 True False False False False False False 0 insufficient_or_context_specific +TRAK2 0.173057746747978 0.403586261366646 0.753672664352895 0.204214471722744 0.324633950299167 0.674724889947951 -0.261343021539704 0.271071451019008 -0.359352641412215 0.0910944335363509 -0.620695662951919 0.0162522145230198 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARFGAP3 -0.205242556004071 0.404283040512639 0.754351785658392 -0.0995253367278064 0.685885707528951 0.883592781626934 0.263885374983288 0.438755593880855 -0.520719524211656 0.0748078340314418 -0.256834149228368 0.403456815229594 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRPF4B -0.117945971816195 0.404326269657212 0.754351785658392 -0.194766097543415 0.164336364276729 0.544850245278 0.346350238272299 1.0 0.492158394389028 0.0454625622353389 -0.164819285241982 0.432037935551611 0.327339109147045 0.143345918951258 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FTCDNL1 -0.458135090910977 0.404494232354905 0.754464505647482 -0.375897444145898 0.499551780677171 0.79038928523746 False False False False False False False 0 insufficient_or_context_specific +PCMT1 -0.157207648722594 0.404529604704527 0.754464505647482 -0.167625817283491 0.372829592423736 0.711428671030148 0.0371716455548803 1.0 -0.158000849962687 0.66169007112966 0.403893279862274 0.145562418823447 0.245892429899588 0.406024236672321 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DPH5 -0.189105309395178 0.404662271132791 0.754471041147377 -0.266336553596488 0.234114166527903 0.603018788225434 -0.156613523450325 0.664941776393881 -0.378773526411941 0.18018828951138 -0.535387049862266 0.0866519301190438 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYNGR2 -0.302881594002486 0.404676028226709 0.754471041147377 -0.0185620082403794 0.963306249374827 0.989935386867005 0.4212364866973279 1.0 -0.217581902290854 0.451129084173494 0.0247291782525136 0.930368255744773 -0.19285272403834 0.453169308794175 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF20 0.212376123845074 0.404985954998341 0.754675440597727 0.0420556936848964 0.868484538173185 0.958502690861149 -0.085274236428818 0.771518108449609 -0.351054722495303 0.114287678575054 -0.436328958924122 0.0717070224109511 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ATRNL1 -0.433767181958862 0.404990463869691 0.754675440597727 -0.271628335625811 0.600179526784857 0.843257280459236 -0.159580888740174 0.713363633773811 0.541229544469066 0.11394879666649 0.381648655728892 0.278289735047507 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC02484 -0.617612619183605 0.405059981986603 0.754675440597727 -0.582527033134062 0.433923960790885 0.751660242498796 0.437692571662835 1.0 False False False False False False False 0 insufficient_or_context_specific +C8B -0.406120060417689 0.405158651045338 0.754675440597727 -0.38654979465696 0.429312780497301 0.74833817673609 0.395525149537938 1.0 -2.45470488265012 0.000107688463744 1.97426361486009 0.0007754435398958 -0.480441267790021 0.168946093056962 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF567 0.21105506117918 0.40518285257654 0.754675440597727 0.262546921262638 0.302534857942913 0.659910120213739 True False False False False False False 0 insufficient_or_context_specific +LINC01473 0.234619010478924 0.405272012630538 0.754675440597727 0.304010437393338 0.284215056403243 0.645043543745796 True False False False False False False 0 insufficient_or_context_specific +F5 -0.408662154766518 0.405475044871502 0.754740244483982 -0.523093008725157 0.286086518944644 0.64687121300967 -1.14829898235076 0.0440171828477748 1.82744009422076 0.0042143350509754 0.679141111869997 0.172707733363931 reversed False False False False False False False 0 insufficient_or_context_specific +FAM200A 0.340478736980238 0.405694071263084 0.754740244483982 0.176958101224964 0.657805636275497 0.871691185476023 True False False False False False False 0 insufficient_or_context_specific +ZNF692 -0.237588988436321 0.40570704399022 0.754740244483982 -0.166700330916739 0.565794989372495 0.824113119711934 False False False False False False False 0 insufficient_or_context_specific +FN3K -0.381976227959162 0.405828724596037 0.754740244483982 -0.56433232450419 0.211300051276018 0.583586702354765 -1.82800498506937 0.0039969080665129 1.31220197615309 0.0154593179240643 -0.515803008916274 0.252406490513998 reversed False False False False False False False 0 insufficient_or_context_specific +UBE4B 0.131924992575735 0.405854882724193 0.754740244483982 0.0910724594882621 0.564825699265286 0.823754286312897 0.571076968436087 1.0 -0.0300681811130577 0.935377233489753 -0.274668332609707 0.269340684881677 -0.304736513722764 0.247369938682454 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PDCD10 0.174024691403785 0.405892698255356 0.754740244483982 0.349462387555314 0.0819614965110115 0.462248842216803 -0.0727751204525215 0.804032337519496 0.226956980514534 0.273755105011265 0.154181860062013 0.497722343196104 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC27A1 -0.236847844832258 0.405991644350804 0.754791297949601 -0.186164209783586 0.516414498815789 0.799726369818831 0.188566088308623 0.603459417483497 -0.625642171664679 0.0424224389507014 -0.437076083356056 0.166576239234014 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OGG1 0.164291090080779 0.406137486548934 0.754929504046416 0.0218894437098873 0.905760365626332 0.970569160690431 -0.215177707648591 0.682672994103038 0.344065392610212 0.361474895467705 0.128887684961622 0.782350101655916 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DNAJC4 -0.366977138316595 0.406240134669821 0.754987386348173 -0.5437514719209 0.208344494436891 0.580837452798758 0.425649720001671 1.0 0.0039776062011035 0.992788933773383 -0.246569273136985 0.357213389521041 -0.242591666935881 0.406626709410067 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CARS -0.219805829819675 0.406379708359354 0.755113861467451 -0.317512562333032 0.234546475813899 0.603410241368636 0.8524688376026259 1.0 -0.0952203519930012 0.774491975155584 -0.454697555548372 0.0765528040091499 -0.549917907541373 0.0496938829356209 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01588 -0.232515697373369 0.40674254791494 0.75552213597571 -0.0588758564316257 0.834390967729076 0.946138957929715 0.392036448964682 1.0 False False False False False False False 0 insufficient_or_context_specific +THRB -0.224623296760979 0.407029397448897 0.755880976607793 -0.182162155999711 0.502364943277746 0.79199179798812 0.471467807511748 1.0 -0.530603586810405 0.202761147882816 0.840910459131599 0.028903330804303 0.310306872321194 0.406024236672321 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GNG12-AS1 0.18695855534844 0.407227203253338 0.755894499737533 0.271464588248191 0.223330535482758 0.594234827022923 True False False False False False False 0 insufficient_or_context_specific +MAFK -0.289450167461895 0.407229391410029 0.755894499737533 -0.429017127670232 0.216234007336924 0.588098570186306 0.5809289260785689 1.0 -0.0235139262059465 0.954939919877077 -0.0004310947921568 0.998750391458399 -0.0239450209981033 0.943937593684866 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLPPR1 0.438508986758004 0.407357163804889 0.755992576608983 0.40274068177386 0.44663511458649 0.761436063265649 True False False False False False False 0 insufficient_or_context_specific +COPS3 -0.184880283427443 0.40748906271499 0.755992576608983 0.0370213269394368 0.863859041597712 0.958391272020028 0.303064783867988 1.0 -0.380428366007545 0.192198193556947 0.415629912488061 0.101326328784016 0.0352015464805159 0.910933031368402 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MED4 0.154788640289248 0.407497040488892 0.755992576608983 0.0805562807203917 0.671674491705031 0.877088599168621 0.83595157964593 1.0 -0.0901309807365779 0.768408825074034 0.152866549176568 0.497927880185292 0.0627355684399903 0.816202501918416 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GGA1 -0.197052785472261 0.40769906185493 0.756101650283568 -0.320019969905852 0.175228028018609 0.557192294943862 0.2780921152044311 1.0 -0.192126759557214 0.418790181582913 -0.27045698733687 0.181346342106623 -0.462583746894084 0.0419004422649963 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NAT2 -0.561890546031395 0.407905062613982 0.756106408334646 -0.829568961058859 0.210596355559582 0.582866063554599 -0.193243503777809 0.684618554469955 0.671557665048639 0.0590515367500685 0.47831416127083 0.200874162356626 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RFX8 -0.496203168865947 0.407923061977894 0.756106408334646 -0.347591615431787 0.563829883530236 0.823754286312897 False False False False False False False 0 insufficient_or_context_specific +LYSMD4 -0.246362761339336 0.408000090666558 0.756106408334646 -0.284732923109936 0.336271120874701 0.684718759551425 0.115905526026459 0.5254620168952371 2.0 0.0717579718656412 0.868885408601504 -0.0184033925092038 0.95590024105768 0.0533545793564374 0.886085409178233 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP2K6 -0.52016166106028 0.408015103484843 0.756106408334646 -0.472819774327389 0.453206374626687 0.765092566410986 -0.561902567914462 0.315013741048436 0.323217381702885 0.497431104834286 -0.238685186211577 0.654546092976197 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAPN1 -0.164308022565766 0.408133727015415 0.756106408334646 -0.0831535542240496 0.680521796829039 0.881048329971919 -0.254817713849892 0.389142034854447 -0.0806102042626877 0.763276683201078 -0.33542791811258 0.207661882348092 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACBD5 -0.202760324620318 0.408141027747223 0.756106408334646 -0.0256771692277159 0.918913011433078 0.975930957742715 -0.454482922483147 0.1770195372694 0.413321018252123 0.166192643274619 -0.041161904231024 0.910751043980256 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC109927.1 0.207088381110113 0.408269660252713 0.756106408334646 0.0326303248567775 0.892212639821725 0.965368150296491 True False False False False False False 0 insufficient_or_context_specific +AC007038.1 0.31828277545897 0.408316184781373 0.756106408334646 0.411501222768291 0.286644779380812 0.646942193395173 True False False False False False False 0 insufficient_or_context_specific +TP53 -0.247670972665065 0.408493441609807 0.756223157073072 0.0427771601848255 0.889771972376788 0.964597236302919 False False False False False False False 0 insufficient_or_context_specific +ZCCHC2 0.187484698006083 0.408657018931249 0.756223157073072 0.33975447504753 0.13694333702884 0.523456610506354 -0.0130539543371902 0.97100168852273 -0.295104517571255 0.232101149942931 -0.308158471908445 0.240492949237043 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ID2 -0.329733218517821 0.408702478184601 0.756223157073072 -0.410378508078614 0.30349256736076 0.660947715799279 0.015746198112161 0.977600175210473 0.286658206767656 0.451522787434133 0.302404404879817 0.453134209035417 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGAP23 -0.21693615071673 0.40876733826634 0.756223157073072 -0.190657380916267 0.471277964837188 0.774918665745371 0.403681571887996 0.40361624431281 2.0 -0.168041393284524 0.525812530369744 -0.37466126688557 0.0923676798660251 -0.542702660170094 0.032067097150882 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL160313.1 -0.266335215793597 0.409157811541253 0.756680359827036 -0.168491872394216 0.603516954941092 0.84524401161854 False False False False False False False 0 insufficient_or_context_specific +RPL24 0.294782134554255 0.409486708528245 0.756890873361557 0.240882897027245 0.50147751395531 0.791065231187833 True False False False False False False 0 insufficient_or_context_specific +SEH1L -0.153898783301171 0.409747386332834 0.757204721639955 -0.0848777888670816 0.653763206904344 0.870639750062571 0.250986194172659 1.0 0.0093048973706048 0.981097781386872 0.275222184525484 0.291047191403322 0.284527081896089 0.303709030038468 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC02018 -0.318363894745942 0.40979994122473 0.757204721639955 -0.112572931354654 0.776361790787262 0.922657083010829 False False False False False False False 0 insufficient_or_context_specific +USP3-AS1 0.209336489974613 0.409993147910318 0.757429161091362 -0.0237216910893328 0.92558407605381 0.978485542437683 0.596184404423027 1.0 False False False False False False False 0 insufficient_or_context_specific +SNRNP48 0.178934202827883 0.410227424604242 0.75761388841555 0.0841214736339652 0.688617030051567 0.884999569552245 -0.233385299545821 0.340641074387507 -0.468916350061422 0.0402647271604851 -0.702301649607243 0.0104953308744077 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PQLC1 -0.338641305707666 0.410236654676236 0.75761388841555 -0.324066669673091 0.43157636883837 0.750342447295744 -0.475012321506122 0.11053449046293 -0.464429921655738 0.0870588631399258 -0.93944224316186 0.0074686959800301 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM126B -0.15196232629755 0.410562026015643 0.758082173954732 0.0102026594634424 0.95623663892402 0.987475198920169 -0.474127617435059 0.281021927434226 0.367881740488164 0.317724369811105 -0.106245876946895 0.809839256930939 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLC1 -0.112582993687642 0.410784121580237 0.758184407090466 -0.124692175611898 0.359669903258642 0.702743831320045 0.8368127676628331 0.4931691772506311 2.0 -0.0686194317857012 0.844911955127034 -0.820542223170133 0.0075827236780093 -0.889161654955834 0.0075508193403489 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ORC5 0.194943488099396 0.41112807611419 0.758184407090466 0.341199414794776 0.148994101849921 0.533583468169136 0.398390674604421 0.0677862542757783 2.0 -0.186019725876911 0.626325397467877 -0.443477679211178 0.143146109032622 -0.629497405088089 0.0678132728164929 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GMPPA -0.29845244527054 0.411131415073478 0.758184407090466 -0.290741002738669 0.424412396225417 0.745581710374036 0.0097943159199083 1.0 -0.185279381225158 0.60206710618139 -0.305953794694056 0.280487442046294 -0.491233175919214 0.111097292665769 partial_or_other False False False False False False False 0 insufficient_or_context_specific +QRICH2 -0.331926297071475 0.411293632982392 0.758184407090466 0.0184503266244886 0.963664477725693 0.989935386867005 False False False False False False False 0 insufficient_or_context_specific +EXT1 -0.19468985906538 0.411335405637625 0.758184407090466 -0.164714552845148 0.486152937465624 0.782071323676502 0.122588764628248 0.728751165734404 -0.6851874465666 0.0236745774988961 -0.562598681938352 0.0630124677724516 partial_or_other False False False False False False False 0 insufficient_or_context_specific +JPT2 -0.275670301583738 0.411345573125648 0.758184407090466 -0.164437167407665 0.632437262289598 0.860473275161544 0.381861489483292 0.472092831822768 0.0510722942412265 0.915528374022562 0.432933783724518 0.351257342825587 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CEP78 -0.153404312477517 0.411464338297069 0.758184407090466 -0.105905002610384 0.57391128085869 0.828799795281911 0.0598997657519687 0.920123076601307 -0.524906173299385 0.184174139162318 -0.465006407547416 0.293560681619979 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP9X 0.119974056888796 0.411502869086408 0.758184407090466 0.148441096928033 0.306761018408725 0.661696690217148 0.270838378768088 1.0 -0.0628964693842365 0.828688869279738 0.032770683185038 0.8916617443103 -0.0301257861991985 0.906401879025802 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CYREN 0.24469446047427 0.411550941185401 0.758184407090466 0.242253190033786 0.416721974697722 0.738213189405797 0.710063132426999 0.4165658476903429 2.0 -0.0923582361633149 0.849204406393966 -0.720001722820046 0.0479797487573282 -0.812359958983361 0.0422708680572219 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRIM66 0.204289857414481 0.411882155902599 0.758505853279408 0.235100764312911 0.343356985958465 0.690244298886038 True False False False False False False 0 insufficient_or_context_specific +BMS1P14 0.447703847192776 0.411940951193799 0.758505853279408 0.406977480952771 0.450858060339284 0.763947905803589 True False False False False False False 0 insufficient_or_context_specific +DNAJB11 0.319412153783177 0.412290993136467 0.759018013170849 -0.0602559983110722 0.88010650404556 0.96227446663699 -0.454213499171402 0.210341677901464 0.49409218520702 0.125916239073411 0.0398786860356174 0.918994607638244 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DERL1 0.206725057149374 0.412489908813718 0.759251823091917 0.183840452787935 0.463832300298005 0.769643508539993 -0.274267767503345 0.337773047283926 0.125036811758055 0.626366748458206 -0.14923095574529 0.580381753163891 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ECM1 -0.426896272729812 0.412733272749405 0.759567351174519 -0.290643619654778 0.579791832608839 0.8320568395656 -0.749083577885761 0.0996569567252262 1.1530346885404 0.0139951898468372 0.403951110654635 0.332670203724069 reversed False False False False False False False 0 insufficient_or_context_specific +ATP5S 0.208755246093381 0.412835149272506 0.759622430466907 0.203714312504956 0.425007625786824 0.745882731558725 True False False False False False False 0 insufficient_or_context_specific +TMEM26 -0.390992270359923 0.413205299562339 0.759991780373341 -0.168030252252719 0.727228558538924 0.903365569206837 False False False False False False False 0 insufficient_or_context_specific +CINP -0.211580693871159 0.413240372817994 0.759991780373341 -0.111506144671778 0.668886358241421 0.875973972998378 0.0534568442374572 0.888959557056515 0.283906050796144 0.267029885847635 0.337362895033602 0.223803203101823 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE2L3 -0.114105523287504 0.413251829051274 0.759991780373341 -0.189498243095968 0.171499856944734 0.552564378607829 0.16670216982653 0.661939924452226 -0.0072515229480572 0.983472411971598 0.159450646878473 0.632793641849744 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGAP15 -0.287291962186302 0.413481060013519 0.760280918081283 0.0398852467814509 0.908989630683581 0.971465990561519 False False False False False False False 0 insufficient_or_context_specific +COX11 0.17469031427345 0.413689155940057 0.76036627857059 0.134712957130044 0.528579367833246 0.805883171925403 0.190162846788425 0.8182928335137429 2.0 -0.0709557036886677 0.895179480351654 -0.12121831683884 0.746711467176359 -0.192174020527508 0.646380343075643 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CCNB1IP1 0.262247264059238 0.413736057435129 0.76036627857059 -0.190328326687037 0.557381318239753 0.821101152222033 0.255387117007348 1.0 False False False False False False False 0 insufficient_or_context_specific +SIGIRR -0.309329065881144 0.413798060669957 0.76036627857059 -0.319577695951958 0.398847821753738 0.728959004281672 0.799048170009197 1.0 -0.242337202162751 0.560983902319736 0.382766077195081 0.226317057508911 0.14042887503233 0.709260809471805 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAJC17 -0.150505401682745 0.413925506126994 0.76036627857059 -0.102208810443071 0.577219313477203 0.830623076419833 0.0152249013328175 0.987029462321711 0.555607052819095 0.271012402323305 0.570831954151913 0.338215880396967 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAH -0.268979142966057 0.413946186790511 0.76036627857059 -0.129549353010351 0.69711741242406 0.888803059281445 -1.00541312999946 0.0119829286059609 1.40213186285685 0.0022129628838547 0.396718732857392 0.232077074069422 reversed False False False False False False False 0 insufficient_or_context_specific +ACSL1 -0.42381713602672 0.414031856654138 0.76036627857059 -0.561746377178347 0.276680192116104 0.639769922987698 -1.15848009729386 0.126894114413948 1.48579938975556 0.0404587480940901 0.327319292461704 0.655006807287611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLNS1A 0.132790892692195 0.414093688740048 0.76036627857059 0.11646190504669 0.473537501081909 0.776216260894705 0.0415590694878377 1.0 -0.103908659680831 0.782041533307582 -0.0698092422635079 0.813044757473799 -0.173717901944339 0.572035909069644 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CMTM4 -0.163550764101035 0.414103627749658 0.76036627857059 0.0970870176391417 0.650901716316683 0.869901306439436 0.38705627784605 0.241779052790946 -0.0092355518304568 0.977646896686367 0.377820726015593 0.214263482750879 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BLNK -0.383575540791068 0.414254358913914 0.76037856770047 -0.7026969395662 0.130750744546901 0.516515197699258 False False False False False False False 0 insufficient_or_context_specific +ARL15 0.185974699602967 0.414555298654098 0.76054451688797 0.315938617039123 0.14986202619486 0.533583468169136 -0.360724634513228 0.284571271476372 -0.325116999890086 0.26635140154411 -0.685841634403315 0.0405196423106954 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RAB6A -0.151535904495559 0.414901772438978 0.76076641167561 -0.0554693953387313 0.771546049252645 0.920641521976153 0.473225302198749 1.0 0.163202285227331 0.542643112857601 0.136796952368803 0.524109453281569 0.299999237596133 0.191950545752524 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DEF8 -0.223170941980135 0.415032471382703 0.76076641167561 -0.36000062740981 0.17626942538663 0.558204137142182 -0.342573306521212 0.19870414087737 0.251626775295854 0.272101085766173 -0.0909465312253577 0.732755111122619 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TPTEP2-CSNK1E 0.186458494751248 0.415042103736647 0.76076641167561 0.26472991011616 0.251540318704036 0.61833822697956 0.280824523462178 0.0612499938151029 2.0 True False False False False False False 0 insufficient_or_context_specific +CPED1 0.214975447343073 0.415145065890119 0.760823052537385 0.11000587399766 0.68168383189114 0.881579850209047 -0.484450758841252 0.127403778637954 0.24146218088287 0.391175780285911 -0.242988577958382 0.408986464094667 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RBMS1 0.159272538927843 0.415285908935102 0.760937467084292 0.186684375504999 0.33601411530787 0.684718759551425 -0.234268162827265 0.37679897285318 0.0299633134457432 0.910368168826668 -0.204304849381522 0.392440463133313 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC007686.2 0.711927953891699 0.415535061976801 0.761063857512066 -0.32096839563613 0.697974488409798 0.889035426303613 False False False False False False False 0 insufficient_or_context_specific +URGCP 0.270867335750277 0.415564798120578 0.761063857512066 0.232173413371905 0.487229825418259 0.782147598778917 -0.0284435820683262 0.919318462326646 -0.281855357299608 0.140755260131223 -0.310298939367934 0.128373819502474 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC079447.1 0.22217331770939 0.415704734162999 0.761188099773317 0.138459011986384 0.6136209318597 0.850434470802666 True False False False False False False 0 insufficient_or_context_specific +AC022816.1 -0.317557592018418 0.415798515778216 0.761209985113432 -0.240733212965483 0.542036192472495 0.813940850536852 False False False False False False False 0 insufficient_or_context_specific +MLEC -0.196292774437177 0.415963796873521 0.761209985113432 -0.0588477827785621 0.809487357979358 0.93302493406858 0.3739963993765349 0.358710329555966 2.0 0.113766869848705 0.772589411333853 -0.0122930830579835 0.97185100123219 0.101473786790722 0.766813623813635 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIBF1 0.1296176305328 0.416107309945546 0.761209985113432 0.117614392384339 0.459651166038739 0.768558565184993 -0.456942754285126 0.394343383238475 -0.387202208550506 0.401688643793852 -0.844144962835632 0.0928916079300922 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ETV6 0.215699289558859 0.416133020402471 0.761209985113432 0.157343601516564 0.556626134062982 0.820941061653668 0.500476205046693 0.529264990533254 2.0 -0.135902249097844 0.772593231311149 -0.0547600810410091 0.891086127382232 -0.190662330138853 0.625684793517683 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ACADL -0.639442950611657 0.416149273922592 0.761209985113432 -0.667408203960334 0.395583098777972 0.726526152518217 -0.20192031922383 0.554902077918115 0.56206237600111 0.0553744195062967 0.36014205677728 0.216694400051608 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HAUS1 -0.221464755113031 0.416255932607397 0.761273191835943 -0.448495773799104 0.0749676849935554 0.452862231765951 0.192320436910237 0.688522162517445 -0.717911860942152 0.0612415803548641 -0.525591424031916 0.199857467098178 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GOPC 0.146140032590938 0.416684545411136 0.761793148130005 0.266727239879543 0.138556808740423 0.523810858054217 -0.0100509900571513 0.978775837181156 -0.047248390947264 0.867591304581815 -0.0572993810044154 0.850958362384589 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CUX1 -0.157306764084353 0.416771915925765 0.761820964048516 -0.325180843280906 0.0858563015373632 0.467503293000484 0.988299017403996 1.0 -0.593555932022504 0.148984616027284 -0.322551617717636 0.376559665033989 -0.91610754974014 0.0298248636211815 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CGRRF1 0.223312978660139 0.417206673739839 0.762219771819558 0.621295862404172 0.0200098603142159 0.332176266033792 0.0301943436012463 1.0 -0.0321333527543941 0.924777329702809 0.249487810651673 0.25713203116744 0.217354457897279 0.364238802853791 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PPP6R1 -0.150215921756189 0.417319680739786 0.762248033148742 -0.271671822311955 0.138959333453378 0.524067528467748 0.152510264506381 1.0 -0.191762538459879 0.512413411705759 0.091742156911272 0.718038383732061 -0.100020381548607 0.715123135841064 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRNP1 0.40363416315711 0.417366535293889 0.762248033148742 -0.148404498521928 0.752963860503277 0.91324439278502 1.06049861878916 0.469842961880277 2.0 0.201130149540881 0.885130826731918 -0.92682249385989 0.321777829400336 -0.725692344319009 0.530240155469403 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCL2 -0.419814797142907 0.417503430960998 0.762276311635797 -0.249412222795805 0.631305502193617 0.859914319858038 0.419378220715414 0.7701694561852959 2.0 -1.41915210635637 0.285019537511524 0.676089468086797 0.563089278050174 -0.743062638269578 0.534912239439034 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP25 0.106240169094636 0.417526416953004 0.762276311635797 0.186076231665282 0.149872444315603 0.533583468169136 -0.0297797129590035 0.938020081411186 0.101458873691475 0.707994043097852 0.0716791607324712 0.814615285484709 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ANKH 0.272871291232265 0.417669185480102 0.762345191205836 0.39248109333477 0.236139181622958 0.604988468715164 0.863491101341995 0.0244084328949543 2.0 True False False False False False False 0 insufficient_or_context_specific +HLX 0.319076876346387 0.417934486882916 0.762345191205836 -0.0077412703794991 0.983834266492655 0.99451887511202 -0.329276599623867 0.316086514183274 0.511836452953281 0.0810981054958252 0.182559853329414 0.553397724125437 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCNJ8 -0.352920146110273 0.418012645983146 0.762345191205836 -0.680856075627837 0.103417253388021 0.47952541118609 0.458240830116641 0.258610255080461 2.0 -0.698410300606604 0.0398247226698036 0.483189619010628 0.0973787424355556 -0.215220681595975 0.479481663529604 reversed False False False False False False False 0 insufficient_or_context_specific +PSMG4 0.249590040156252 0.418055036119044 0.762345191205836 0.226613268547421 0.462369182880777 0.769320698854699 -0.185518196323353 0.677175400417328 -0.0280382557248845 0.942891623180218 -0.213556452048238 0.574442723444002 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PAXIP1 -0.152976104219227 0.418161804178699 0.762345191205836 -0.0816344551467364 0.660638176930974 0.8725316327292 0.0131136817618175 0.975745341811225 -0.139071762995689 0.640378336306196 -0.125958081233871 0.705831888568513 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NEU3 0.198751091203218 0.418171778049503 0.762345191205836 0.194095101526778 0.429240780167258 0.748336221434264 -0.116323093092355 0.751798143959638 0.0651138458032038 0.828009718620205 -0.0512092472891516 0.880479397049426 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BTF3L4 -0.148565131614958 0.418210240959951 0.762345191205836 -0.108872385879418 0.556077303407547 0.820783471183682 False False False False False False False 0 insufficient_or_context_specific +RPL36 0.297173844713213 0.418286199342244 0.762345191205836 0.518041342136315 0.171738765457556 0.552641842639707 0.438112207096332 1.0 True False False False False False False 0 insufficient_or_context_specific +MRI1 -0.169851909534725 0.418491595261055 0.76249536082058 -0.115778044066287 0.577815410096017 0.83075298180061 -0.277133316814465 0.325940113374392 -0.3911659088891 0.114469864375181 -0.668299225703565 0.0232050006147352 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PROX1 -0.456271091083255 0.418513034282559 0.76249536082058 -0.772075978735003 0.164464740539538 0.544850245278 -0.84035392414428 0.0592354571252899 0.608608335668591 0.117545321797604 -0.231745588475689 0.57585981979015 reversed False False False False False False False 0 insufficient_or_context_specific +INTS7 -0.177628421654443 0.418680957994722 0.762576365143608 -0.0744891214073791 0.727140331653498 0.903365569206837 -0.175026137353944 0.682045197328076 -0.276298347747468 0.400678101529428 -0.451324485101412 0.201679328734008 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRSF9 -0.229421085704521 0.418725513319111 0.762576365143608 -0.560848127344778 0.0254439711109255 0.351006805738558 0.065138471011915 0.870140110092645 -0.538151021940002 0.0664655705109666 -0.473012550928087 0.115859936935867 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCC10 -0.160525916099543 0.418774177410744 0.762576365143608 -0.102654570263433 0.603127224210513 0.845016786554015 0.5009459450930229 1.0 0.0166776278620246 0.964510570781438 -0.604471348037584 0.0316870203784064 -0.58779372017556 0.0451500810696455 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RABGGTB -0.263890128201943 0.418944819820528 0.762626061671264 -0.183275925589609 0.574632080622838 0.829273579444496 -0.351168394564163 0.309994200020529 -0.0338844174672791 0.92329845476934 -0.385052812031442 0.221192001575577 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERO1B 0.217884277143202 0.419095820272344 0.762716834627854 0.0718358414851451 0.792404857692011 0.927620871373898 True False False False False False False 0 insufficient_or_context_specific +WDFY3 0.149932363438041 0.419146610279601 0.762716834627854 0.289645791829416 0.108059027300828 0.484247542547601 -0.0137653876659893 0.96472060374889 -0.0850606263238526 0.705950581889845 -0.0988260139898419 0.682847153251179 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF148 0.129375057151791 0.419336593895448 0.762716834627854 0.144093412663792 0.366304093469576 0.707887999926555 True False False False False False False 0 insufficient_or_context_specific +TSPAN15 -0.408979201197496 0.419426419860005 0.762716834627854 0.0376171613718163 0.944251189920388 0.984924329498069 0.61542372450603 1.0 -0.83849362395135 0.175144956637759 0.971524596223625 0.0610256644262438 0.133030972272276 0.820809532234531 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DGKZ -0.197986514201741 0.419470749473776 0.762716834627854 -0.196910454440646 0.422023246628836 0.743984210704166 0.335288602057585 1.0 -0.0356366208407571 0.914881531455775 -0.31557174118366 0.164011432010235 -0.351208362024417 0.142442849335637 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDLIM5 0.223284895907514 0.419501483110812 0.762716834627854 -0.0142815245497394 0.960305840072874 0.988836580730567 0.6815472923951811 0.739724130174678 0.0952386588781788 3.0 -0.077448537297436 0.859070568791721 -0.643153471875869 0.0501383785361615 -0.720602009173306 0.0392822041264364 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDX41 -0.368094150366272 0.419643535112308 0.762843740309186 -0.594910743811346 0.173131607114082 0.554336007536445 -0.224829231834653 0.415516431416752 -0.273807598280704 0.238178461086442 -0.498636830115357 0.0556752012051446 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PBRM1 -0.100772972935032 0.419767089384682 0.76293698222129 0.037346311316658 0.757347991031779 0.914454644719928 0.322307566848512 0.571009975497792 2.0 0.553253396225438 0.0459920444296579 -0.18718505139759 0.413907229381968 0.366068344827848 0.147753090778002 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZCCHC17 0.179604948591101 0.420498711114844 0.763558734538902 0.0192981933872588 0.930892974692631 0.980624704721547 -0.188685915702564 0.682045197328076 0.123198761507005 0.737986505696914 -0.0654871541955591 0.88142566120496 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SYS1-DBNDD2 -0.290837129574746 0.420567342224272 0.763558734538902 -0.269934611469022 0.456586885227195 0.767129906783692 False False False False False False False 0 insufficient_or_context_specific +FANCC -0.121767705430424 0.420725207877808 0.763558734538902 -0.11109486005311 0.46058627496067 0.768745132096508 -0.0365111611343794 0.937235553585745 -0.231104128440344 0.446294688117312 -0.267615289574723 0.427280308808576 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF302 0.153611712497219 0.420927062064867 0.763558734538902 0.0678409876548473 0.721938575896906 0.901079026400229 0.39330520925508 1.0 True False False False False False False 0 insufficient_or_context_specific +TMEM8A -0.230857659906942 0.421017026820794 0.763558734538902 -0.13617043913337 0.640526315185629 0.864640237429136 False False False False False False False 0 insufficient_or_context_specific +ACSL4 0.216369046439497 0.421401923183122 0.763906479704076 0.24218481405 0.365080791696644 0.706387878106228 -0.130500320487769 0.657850240376196 0.0840921540629237 0.729028822328023 -0.0464081664248452 0.869077705378564 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC099518.3 -0.332030574208098 0.42145815914721 0.763906479704076 0.093961240173801 0.823776482221281 0.94026292965322 False False False False False False False 0 insufficient_or_context_specific +LINC01135 0.269466146564082 0.422164681219975 0.764522343498789 0.364225806962692 0.277855369040318 0.641126042022682 True False False False False False False 0 insufficient_or_context_specific +KCNMA1 -0.509586189370403 0.422206893500245 0.764522343498789 -0.674203096176454 0.284077522232695 0.645043543745796 False False False False False False False 0 insufficient_or_context_specific +MDN1 -0.134968786503251 0.422280761529639 0.764522343498789 -0.121188941491938 0.470692516814179 0.774676753689306 0.334214484568442 0.394037389863102 -0.124046625007939 0.706771022586088 0.210167859560503 0.567297445467495 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARMC6 -0.26942580924051 0.422409714531421 0.764522343498789 0.0044322692532799 0.989706551536935 0.996896452948454 0.334505298623052 0.504688178407698 -0.109582745451272 0.790523637935982 0.22492255317178 0.625804260474455 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADCY9 -0.179787312719361 0.422449645005866 0.764522343498789 0.0538136333295591 0.812253801701003 0.934078601280818 0.8186774757292891 1.0 -0.629500302081426 0.0669338624594166 0.493769166444329 0.0957372566001458 -0.135731135637097 0.681075380055899 reversed False False False False False False False 0 insufficient_or_context_specific +VPS28 -0.252814110348887 0.422854818413165 0.764580101763606 -0.122035929088789 0.703758630976927 0.891883762556044 -0.150884077124353 0.606365617580331 0.325832224769168 0.160795670119439 0.174948147644815 0.483753184944942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFYVE9 0.112599262525598 0.422885329274841 0.764580101763606 0.0224282036593628 0.871876981748408 0.958683313195135 0.453435582261853 1.0 -0.0977577448687487 0.770025916959417 0.205906433650836 0.388961450570219 0.108148688782088 0.700735754549525 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SCUBE2 0.294515373599793 0.423084071037656 0.764580101763606 0.535193105765223 0.155625179214759 0.539558215777 True False False False False False False 0 insufficient_or_context_specific +CLP1 -0.299898264696407 0.423154421923915 0.764580101763606 -0.515721019134402 0.150243264412677 0.533583468169136 0.117218496923506 0.760199212498687 0.118827611138822 0.674209864373547 0.236046108062328 0.436822972756224 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCBE1 0.286308355007981 0.423165496144004 0.764580101763606 0.344041868553927 0.335168129279752 0.684461073909613 0.219736119539275 1.53757593711509 2.0 -0.291958676488611 0.478082881937021 -0.185527215791127 0.600819903828675 -0.477485892279738 0.186825044249977 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ATG14 0.229786879269478 0.423193762132469 0.764580101763606 0.0163415261594002 0.953911917472937 0.987292667741163 -0.412517318314312 0.195270061745378 -0.0452901529470191 0.886719996633009 -0.457807471261331 0.125149375302564 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SDC1 -0.321058176003935 0.423253492489252 0.764580101763606 -0.147457407801071 0.716478117885947 0.897727094974894 -0.396569505316154 0.221094369266366 -0.220550773401458 0.444504571381064 -0.617120278717612 0.0519220132385737 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAPN10 0.233014466505319 0.423437193654961 0.764610799671671 0.0341659111001834 0.904824436394021 0.969884267885983 -0.19304889496293 0.429439240705777 -0.370583986485579 0.0810809258185391 -0.563632881448509 0.0231231169083614 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KIAA0586 0.141200141346647 0.423860304839026 0.765093252766925 0.106235518198188 0.549254890272589 0.816365047001981 True False False False False False False 0 insufficient_or_context_specific +CDC42SE2 0.123368431842095 0.423924562292718 0.765093252766925 0.13452774481654 0.382847766259469 0.718596749540883 -0.0873676076815458 0.879594841158589 0.153605561307323 0.701697581591658 0.0662379536257767 0.892828755240047 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LPA -0.710458754462488 0.424030506421417 0.765099892996577 -0.792024324769518 0.37168099391207 0.710253546178141 False False False False False False False 0 insufficient_or_context_specific +SUN1 0.130437148096893 0.424073174258 0.765099892996577 -0.0315830758969584 0.849129929692599 0.953127856970211 0.387376206846937 1.0 -0.101675490800747 0.72340451607846 -0.18714531719526 0.392758950407652 -0.288820807996008 0.217041369480811 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HMCES 0.297696978543783 0.424829665972461 0.765579345650124 -0.175823120597101 0.640796413163405 0.864640237429136 0.237526149691015 1.0 0.0554337220277832 0.874976692694041 -0.889303776347671 0.0051240014823383 -0.833870054319888 0.0107550361347177 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BAG6 -0.272819028051436 0.424929874919583 0.765579345650124 -0.424741445434096 0.20628211572205 0.579235791966332 0.391471005181975 0.0273192811093464 2.0 -0.0661083844846793 0.80772018428236 -0.515303010975427 0.0204228386915211 -0.581411395460106 0.0169978098220552 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAU 0.270452478518622 0.425025201437193 0.765579345650124 0.545016789794739 0.11595993958016 0.494328725999491 -0.234127106296792 0.549523397858711 -0.0871525297739742 0.80270282924597 -0.321279636070766 0.338364017902789 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CUTC 0.178702461388402 0.425281574373743 0.765579345650124 0.284034061677086 0.212295433047594 0.585073135504176 0.0262348645596525 1.0 -0.786781054730585 0.120463063756945 0.482016497702361 0.257575353126958 -0.304764557028223 0.508954021577613 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HBS1L 0.15861070783617 0.425742654665342 0.766017543959899 0.114696240132094 0.563979899867092 0.823754286312897 0.254641558001089 1.0 True False False False False False False 0 insufficient_or_context_specific +QDPR -0.261745389642481 0.426026030550145 0.766269268812412 -0.107090266115009 0.750465233560117 0.911659131290248 -0.894932713101824 0.0682205850246591 1.38244814646624 0.0084536844581115 0.487515433364417 0.271888184925879 reversed False False False False False False False 0 insufficient_or_context_specific +NT5DC2 -0.374107141120034 0.426160790996623 0.766378066997505 0.0920985083082959 0.853481999571789 0.95526155065304 -1.14387735462529 0.0145779809135334 1.0656157433789 0.0144032326698679 -0.0782616112463883 0.859742070065194 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF346 -0.167980255514055 0.426845413061453 0.767217206520739 -0.0519477102185129 0.806987603991428 0.932788199072101 0.45947838965993 1.0 False False False False False False False 0 insufficient_or_context_specific +AC004943.2 0.255908205479465 0.427103876090197 0.76739657291566 0.222907339446331 0.487797527923448 0.782700045564705 True False False False False False False 0 insufficient_or_context_specific +CASD1 0.177513967972051 0.427163256206226 0.76739657291566 0.37723407437492 0.0784985659941544 0.457322349441485 -0.1398807309842 0.580581821580096 -0.0829215561853703 0.695608897198272 -0.222802287169571 0.29961781278568 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HERC2 -0.0895903619284802 0.427426923519969 0.767739615264347 -0.142407172951931 0.197896297190735 0.572749206617264 0.240995912359677 0.445583082983027 -0.228213474502239 0.377291093572135 0.0127824378574376 0.970079951115289 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AGTR1 0.351822965557103 0.427635928136191 0.767936159735195 -0.0737509088702959 0.865650276322596 0.958391272020028 0.585782458384509 1.0 False False False False False False False 0 insufficient_or_context_specific +ESCO1 0.113262031081685 0.427681816560234 0.767936159735195 0.0419317521962433 0.768894825600433 0.920094250106468 0.388037257438942 1.0 -0.176834358103428 0.690731395913783 0.288801668381056 0.377146670941356 0.111967310277627 0.778389943524509 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LILRB5 -0.681694887615602 0.428138171985121 0.768363559377682 -0.827549058233203 0.325475834865023 0.674724889947951 False False False False False False False 0 insufficient_or_context_specific +NCK2 0.178493399197957 0.428420897690114 0.768740285148237 0.300406558691143 0.183335759529467 0.565541146173142 -0.130614388220611 0.660397145252821 0.238484938965438 0.293485298780139 0.107870550744827 0.680376397065629 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DMXL1 0.0924121584835524 0.428513446334877 0.768775695225766 0.159332754725868 0.165392232764479 0.545468009482397 -0.210642197919212 0.409234820448561 0.0437965932305923 0.856631457818978 -0.166845604688619 0.468741515196619 partial_or_other True False False False False False False 0 cross_species_direction_conflict +POLR3E -0.198541222103275 0.428711459031843 0.768870863528439 0.0450226637932401 0.854190298744096 0.95526155065304 -0.482191010006037 0.135641781107942 -0.0045533108402518 0.989377741631593 -0.486744320846289 0.108659470327042 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DPYD 0.142496590285067 0.428784963483183 0.768870863528439 0.147653902479148 0.41034671760712 0.735152897523944 0.112692387384692 0.179817100942819 2.0 -1.43259223397051 0.0020148379178556 1.06841019270375 0.0080112576849898 -0.364182041266761 0.282066306090083 reversed True False False False False False False 0 cross_species_direction_conflict +PLB1 0.451358301167168 0.428875952045047 0.768903430411209 -0.141031203518238 0.80235353710302 0.930804158304986 0.73395099059645 0.690803254714875 2.0 False False False False False False False 0 insufficient_or_context_specific +ZNF778 -0.221080945478704 0.429040805619736 0.769068391465734 -0.179721044833642 0.523736194526854 0.80370058056999 1.05211823742381 1.0 False False False False False False False 0 insufficient_or_context_specific +CDC40 0.194693230679247 0.429311561080995 0.769423096569878 0.407416882175957 0.102404111386515 0.479137456027696 -0.0447320962677349 0.935213899875858 0.0385556468996446 0.924756353965714 -0.0061764493680903 0.989304566982475 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CYP8B1 -0.410620928569438 0.429413105981009 0.769474469271468 -0.416029808192176 0.423377813204096 0.744631509546701 1.094727607353 1.0 -2.69071162664126 0.011939000073687 2.04540928312782 0.0295797296675313 -0.645302343513439 0.445744294814978 reversed False False False False False False False 0 insufficient_or_context_specific +TRIR -0.18140442412132 0.429657114268225 0.769650460204262 -0.101314166991417 0.658844454691145 0.871710320505013 -0.486675287710452 0.0896373355947501 0.233093954604202 0.355523158408844 -0.25358133310625 0.334622238532162 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF165 -0.437504294644062 0.429764965571595 0.769664468411989 -0.46908036271774 0.396672341152751 0.727600169890679 0.134852645281498 0.834983959905929 -0.437317765672053 0.315838499466496 -0.302465120390555 0.560266780675777 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UPF1 -0.192225956795649 0.429883870507847 0.769664468411989 -0.35922767319065 0.118022366396325 0.497635840420285 -0.104818741492317 0.743210363848798 -0.20931553549618 0.388726195136093 -0.314134276988497 0.219640401185941 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DGUOK 0.161281330138596 0.429894442161058 0.769664468411989 -0.0700925591341464 0.712796164365712 0.895497343705388 -0.162997081628367 0.684526472747504 -0.0619406231361894 0.857718767122906 -0.224937704764557 0.503646453560892 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC092683.1 0.229473017997448 0.430055624567525 0.769664468411989 0.287583974722638 0.32208079153345 0.672877524535327 0.131845587689576 1.0 True False False False False False False 0 insufficient_or_context_specific +LRRTM4 0.660517748733544 0.43011497515533 0.769664468411989 0.810805404249384 0.335678898243968 0.684461073909613 True False False False False False False 0 insufficient_or_context_specific +ATP6V1H 0.146518937156106 0.430124208024511 0.769664468411989 0.190074588407024 0.300089076571907 0.658405125798708 -0.0534652035495986 0.885130826731918 0.212840270757463 0.396053714246671 0.159375067207865 0.565636870206166 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF641 -0.15916447002789 0.430175225241442 0.769664468411989 -0.0461674810783857 0.821039988943823 0.938255244427848 False False False False False False False 0 insufficient_or_context_specific +AC096564.1 -0.550343547211448 0.430274161945117 0.769711047410462 -0.586906587598036 0.399946801969736 0.729928839273374 False False False False False False False 0 insufficient_or_context_specific +STARD9 -0.170553339013953 0.430704843377262 0.770220483803714 -0.0740361623885803 0.734196935834019 0.904977889122883 0.728132321009726 0.01655869562227 -0.301518761311202 0.200570996484521 0.426613559698524 0.1122071458818 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FKBP9 -0.157504047322209 0.430864279840857 0.770375117114271 0.0237531841220805 0.912259575715524 0.972990867805283 0.371327191315915 0.196782791853917 -0.462076264167188 0.0782925066951203 -0.0907490728512725 0.757360396466412 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00662 0.161450670178102 0.430951832710656 0.770401193660532 0.373483902796564 0.063854164725011 0.432999502601999 True False False False False False False 0 insufficient_or_context_specific +UBE2F-SCLY 0.288587778897572 0.431373895540605 0.770572890300395 0.240238651324977 0.510913584829139 0.796519013040946 0.310841812121613 0.399433699255029 2.0 True False False False False False False 0 insufficient_or_context_specific +MPDZ 0.123491721694314 0.431384060483294 0.770572890300395 0.10620290303633 0.499000291103173 0.789990264427546 -0.197477922403008 0.412448068065036 -0.377825398317699 0.0736734941147535 -0.575303320720707 0.0206212459289334 partial_or_other True False False False False False False 0 cross_species_direction_conflict +P4HTM 0.251279769469092 0.43141562800826 0.770572890300395 0.200040803283023 0.531893476997364 0.808950061961706 0.338004584565361 0.381876937223829 2.0 -0.178806580506702 0.840035263543365 -0.24440237708427 0.701257766351356 -0.423208957590972 0.542350095476212 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SUGP1 -0.219696155638257 0.431485785892777 0.770572890300395 -0.53286053620012 0.0408030977452519 0.38602070429603 -0.103063647536943 0.796041672509641 0.0386703888778958 0.906356154719516 -0.064393258659047 0.854661951271879 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC006978.2 0.198848578388552 0.431685000759398 0.770687147728228 0.410313620286766 0.0928544419130975 0.472689102082201 True False False False False False False 0 insufficient_or_context_specific +NOVA1 -0.319424119595997 0.431785020969327 0.770687147728228 -0.141697457759326 0.727372774347771 0.903376279445214 False False False False False False False 0 insufficient_or_context_specific +HACD2 -0.190313429309933 0.431841747107426 0.770687147728228 -0.107554736813196 0.658860424098315 0.871710320505013 0.3123626537139519 1.0 -0.117859008149771 0.878678760833793 0.892012563869048 0.0693683807391542 0.774153555719277 0.148593982459288 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM87B -0.207768152043563 0.432163898516295 0.770871167517325 0.0254584871275006 0.923003565537471 0.97777552504144 0.46116798800547 0.834173567719381 2.0 0.0555297706837647 0.872628917234512 -0.316098236660224 0.190772188812458 -0.26056846597646 0.310100188256524 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GUCD1 -0.271928478550172 0.432422218104241 0.770890456640595 -0.387216783811276 0.256101541058842 0.620670263344767 1.69164473869965 1.0 -0.798108765854506 0.0595318206522888 0.657225555840453 0.0810809258185391 -0.140883210014053 0.732945190435209 reversed False False False False False False False 0 insufficient_or_context_specific +AL135999.1 -0.280545423624997 0.432650251524982 0.770890456640595 -0.199057364159479 0.580623689344543 0.832684720469939 False False False False False False False 0 insufficient_or_context_specific +UTP6 -0.157487138382849 0.43266878248524 0.770890456640595 0.0296085151094519 0.88066992368832 0.96227446663699 -0.0236604507773835 0.943628346975369 0.244366800840851 0.264058990701447 0.220706350063467 0.350354233455813 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC7A8 0.449638891573703 0.432758830887366 0.770890456640595 -0.150827656078998 0.79064494716026 0.92749893235615 0.446012257649115 0.0129889487056018 2.0 1.09926842998417 0.109996634454539 -0.460783507905463 0.356910779715427 0.638484922078706 0.332496888140221 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAI14 -0.301451909248002 0.433091833674108 0.771131799171808 0.172454312802996 0.642296635061342 0.864970391961435 0.500707583015049 1.28711847365296 2.0 0.324012684633228 0.219905644481465 -0.346541012834081 0.135978364317319 -0.0225283282008534 0.937535796537767 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VAV3 -0.390728286476686 0.433103397185027 0.771131799171808 -0.263381880368739 0.599919780505668 0.843257280459236 False False False False False False False 0 insufficient_or_context_specific +PNISR 0.119962428102828 0.433136987250497 0.771131799171808 0.0803264482220918 0.599326846647426 0.843166766555993 -0.184484812557835 0.65674314972199 -0.3512695895968 0.284635847796219 -0.535754402154636 0.124180783085589 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRPS31 0.145805791094343 0.433186465323735 0.771131799171808 -0.0246083318313184 0.895675249258547 0.96715797942752 False False False False False False False 0 insufficient_or_context_specific +MTRR 0.176366875666146 0.433409374723525 0.771323127839045 -0.0417905824868271 0.851855613737439 0.954259052502905 0.516077373447875 0.535984618595277 -0.664838317428711 0.288089877910922 -0.148760943980836 0.865336397643711 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RALGDS -0.208644090248955 0.433619489096273 0.771512397350598 -0.21804427223664 0.413035503808899 0.735665071926961 0.214698492661444 0.495660090957187 2.0 -0.294519250900309 0.509412539513543 -0.260913120580268 0.479639447195101 -0.555432371480577 0.157760104772429 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GSPT1 -0.172051855731109 0.43377286458383 0.771645024729839 0.0877758553556596 0.681569070059373 0.881539414637616 0.272548089460814 1.0 -0.09927707253299 0.709033686275897 0.148975145865915 0.465787572977052 0.0496980733329251 0.840274776798135 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUP54 0.151963096590742 0.43391328962124 0.771645024729839 0.38252345902958 0.0507695292628915 0.408254884487698 0.318638541579279 0.0619654091146417 2.0 -0.193086609769304 0.503388661270573 -0.462358795964634 0.0626044037482205 -0.655445405733938 0.0234602469106672 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC092155.1 -0.454483464050239 0.434079927124662 0.771655590441062 -0.600496447575073 0.295443381016601 0.653036159190561 False False False False False False False 0 insufficient_or_context_specific +ISG20 -0.352598084537047 0.434317839850724 0.771655590441062 -0.383709367981345 0.394457269794244 0.726080478554543 0.365243369634404 1.0 0.307325876791342 0.464985416596068 -0.227005212011961 0.493045756929981 0.0803206647793809 0.85058335649462 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DVL1 -0.332203934294339 0.434389042411823 0.771655590441062 -0.213835156409772 0.621270393246574 0.854367282027973 1.13057028809845 0.0203273104270013 2.0 -0.0684097069630573 0.81310596327621 -0.743284009186459 0.0054451042448924 -0.811693716149516 0.0055036204162686 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCAF1 -0.185220917118771 0.43453643044083 0.771655590441062 -0.188944186572924 0.424851172796512 0.745882731558725 0.260394335217871 1.0 0.140865021755833 0.690830450507199 -0.503410483595565 0.0789510692689486 -0.362545461839732 0.216568066867294 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GNPNAT1 0.249078512190151 0.434539986200764 0.771655590441062 -0.0609429680738241 0.84249581720751 0.950469545398617 0.0882443199833838 1.0 -0.033173977933917 0.919132790389755 0.121628830693417 0.587793266386785 0.0884548527595002 0.727281137768212 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYNRG -0.112658354237485 0.434654315134456 0.771655590441062 -0.0852345185054379 0.557217991738807 0.821101152222033 0.691148836349938 1.0 -0.270801816170343 0.371048661424072 0.147701954109474 0.566264296194568 -0.123099862060869 0.671408448395402 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPL2 -0.179381417028654 0.434685722278108 0.771655590441062 -0.315138193363678 0.166675115681312 0.546847691536137 False False False False False False False 0 insufficient_or_context_specific +IFT20 0.265848922278772 0.434704965541863 0.771655590441062 0.508326359595856 0.138950265380802 0.524067528467748 -0.196775757276593 0.476266397519509 0.455537938179279 0.0574511026544237 0.258762180902686 0.28063652643436 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COPS7B 0.197941866297241 0.434781372191397 0.771655590441062 0.383044234064373 0.119322985372658 0.499900248662619 0.0331479993663986 1.0 -0.270500141641326 0.38610586885257 -0.781399019415523 0.0132242980310499 -1.05189916105685 0.0055519882210824 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARL6IP5 0.187098689532705 0.434841135762666 0.771655590441062 0.371092804949167 0.139739369318791 0.525229000095333 0.268218219714523 1.0 -0.126802692374962 0.70588917762683 0.161660303473479 0.537385612990621 0.034857611098517 0.91442693016402 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CHP1 -0.220996878089386 0.434915756793505 0.771655590441062 -0.246615158560325 0.384147684540261 0.719298323474503 -0.789475473480855 0.0645329097052804 0.941257157672599 0.0228297941514214 0.151781684191744 0.715134491056259 reversed False False False False False False False 0 insufficient_or_context_specific +UBE3C -0.0977809640702849 0.435055764955028 0.771655590441062 -0.119432859156338 0.335145813580696 0.684461073909613 0.0285220610294041 0.933454155949399 0.155420333602288 0.490066411140103 0.183942394631692 0.447637017828684 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RINT1 -0.201835453074452 0.435374491971098 0.771655590441062 -0.239731101796582 0.349511669453794 0.694288655897113 -0.243629745623574 0.429914091319609 -0.815279602453713 0.0099090039390119 -1.05890934807729 0.0048935938399001 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC105052.1 0.22194981833203 0.435380976724513 0.771655590441062 -0.183548143302112 0.540259031406005 0.812783927483158 False False False False False False False 0 insufficient_or_context_specific +ATP7B -0.278412719507662 0.435492730022222 0.7717241093613 -0.246264511265442 0.492044319116928 0.785931001699929 -0.731007580314074 0.100342665080673 0.332500057553457 0.382930111628606 -0.398507522760617 0.319795771820636 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TANC1 -0.210193246151422 0.43579041568209 0.771992484693205 -0.0514302771724355 0.846004863294606 0.951935443160717 0.444231193584941 1.0 -0.111837208482977 0.758075819087172 0.186242998977664 0.492681535701222 0.0744057904946868 0.816536064181449 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC093157.1 0.239433832370069 0.435902452756554 0.772061415232964 0.276561776865465 0.368157490704652 0.708317354196916 0.0131943427112169 1.0 True False False False False False False 0 insufficient_or_context_specific +EIF4G3 -0.147951926075175 0.436030992528466 0.772159546983485 0.0037942554125787 0.983684420673734 0.99451887511202 0.3715892715846071 1.0 -0.370779918227444 0.203679787608732 0.302188503609732 0.238178461086442 -0.0685914146177116 0.82071832347107 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MXRA5 -0.333586238486094 0.436132908784265 0.772210506614836 -0.571767553632347 0.161389473059012 0.543541307772207 False False False False False False False 0 insufficient_or_context_specific +NUP35 0.218982275426856 0.437543465532829 0.773887290967011 -0.0791579859147513 0.787030319413371 0.926252207338503 0.0207833743842613 1.0 0.252317314396441 0.573573228483649 -0.0283045868034862 0.94109271294316 0.224012727592954 0.573209548736223 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DACH1 -0.388837945963146 0.437738968594502 0.773887290967011 -0.215636742847756 0.667380046344516 0.875419277100913 0.268720076528484 1.0 0.329587524705654 0.535610699413504 -0.770948921258852 0.0820438650438193 -0.441361396553199 0.348966138655821 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NPEPPS -0.100599997588131 0.437852173342759 0.773887290967011 0.0687572684812496 0.592126890534629 0.83882246935128 0.240522222394716 0.545893502687517 -0.484535678585971 0.134162752369018 -0.244013456191255 0.490123065276328 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ORAI1 -0.367526446748911 0.437926121597573 0.773887290967011 -0.854079045292482 0.0453395280311257 0.395615485084814 -0.261988239479773 0.615951598187487 -0.0328421276323349 0.944596460537392 -0.294830367112108 0.512450333905194 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARMC5 -0.340346447642062 0.437956294876994 0.773887290967011 -0.523410392664931 0.224878510993215 0.596849502027745 0.152732937745919 1.0 0.328723088210958 0.512100614330742 -0.856563847032452 0.0470467636611634 -0.527840758821494 0.24603480979597 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DHX15 0.147750647759082 0.437957003694349 0.773887290967011 0.259432889117848 0.164284538167544 0.544850245278 -0.0863124302474546 0.784989284404302 -0.209432360157443 0.372505596882872 -0.295744790404897 0.232210953484197 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KHSRP -0.190374963717273 0.437959515393814 0.773887290967011 -0.249425153390441 0.306844761820719 0.661696690217148 0.32373427068354 0.288110716480293 2.0 -0.197209838925359 0.462710862303314 -0.0333308166060585 0.899696015030382 -0.230540655531418 0.328115501878997 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDC73 0.138503662151017 0.438264974994431 0.774194092111134 0.174479843120638 0.326542966167763 0.675949642085426 0.6240811935639721 1.0 -0.0253708394154118 0.944094059459756 -0.236862284678439 0.326316041603655 -0.262233124093851 0.309311746049473 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAP3K6 -0.276709030238061 0.438297529047886 0.774194092111134 -0.47843375398021 0.170877441649696 0.551551216428459 -0.347469742569571 0.483509605781318 -0.0289285468438634 0.95112927425907 -0.376398289413434 0.387633225509222 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HDAC5 -0.184427895612016 0.438353123947752 0.774194092111134 -0.391949725876454 0.0906639084303069 0.472234212482528 0.0800802156951799 0.758590605568299 -0.178176429312327 0.359911898746699 -0.0980962136171474 0.655316934567585 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MT-ND5 -0.155909475866526 0.43869233857639 0.774663607742017 -0.290067114002969 0.14777813400083 0.532869377998896 -0.94174722357144 0.0566505257894019 0.789247376881107 0.0754414628971925 -0.152499846690333 0.754217099898421 reversed False False False False False False False 0 insufficient_or_context_specific +ALDH5A1 -0.245074041998331 0.438839350598496 0.774700483102539 0.0211387098910571 0.946098646024577 0.985432868134933 0.52058523286701 1.0 -0.138527175720046 0.770405194413138 0.752891616355979 0.0402647271604851 0.614364440635933 0.100359027519763 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GIGYF1 -0.185929624503321 0.439081549327378 0.774700483102539 -0.204301982274871 0.393219903480945 0.725247545582736 -0.187770935102332 0.559292204405682 -0.835716264388277 0.0089206987646578 -1.02348719949061 0.0054754544213621 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC26A6 -0.383349435378757 0.439150955509595 0.774700483102539 -0.413620188884081 0.400836769505388 0.730608696937787 0.0814768654731135 0.894007251621826 -0.79731420538881 0.0665419491653649 -0.715837339915696 0.131865448008291 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FGA 0.268654834827021 0.439204579399619 0.774700483102539 0.430623602382909 0.21487910360165 0.587852789707652 -1.58419945794894 0.0038115064548511 1.39661186671639 0.0063741880412067 -0.187587591232554 0.678208049807557 reversed True False False False False False False 0 cross_species_direction_conflict +AC078785.1 -0.26790625502593 0.439208680928099 0.774700483102539 -0.13795437112058 0.697254818661263 0.888803059281445 False False False False False False False 0 insufficient_or_context_specific +AC008438.1 -0.284021081016703 0.439278006165509 0.774700483102539 -0.0977955877863021 0.791615414525481 0.927588847807277 False False False False False False False 0 insufficient_or_context_specific +SPECC1L -0.336186357105097 0.439337368463135 0.774700483102539 -0.369047635079894 0.396092272217071 0.726915037383597 0.523287522745438 0.284869232183315 2.0 0.180026440397049 0.501269502126959 0.0259913183344669 0.919100420181174 0.206017758731516 0.376873885263803 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC12 -0.177439855676377 0.439373602274863 0.774700483102539 -0.187971674214426 0.411549491420972 0.735291083225579 0.977173324706852 0.5356436384469899 2.0 -0.0231871527355889 0.947684041212993 -0.322597089138172 0.168969951559108 -0.345784241873761 0.166830055698032 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP5PF 0.245581591775882 0.439472617299524 0.774714628788857 0.546177336777808 0.104093599549823 0.480263154193818 True False False False False False False 0 insufficient_or_context_specific +ZNF212 0.264582355239343 0.439536269019647 0.774714628788857 -0.0672985708960288 0.842231295728826 0.950435872200187 False False False False False False False 0 insufficient_or_context_specific +IL34 -0.355155771154992 0.439629191862094 0.774714628788857 0.12665414300834 0.782520393309061 0.924647355053618 0.111339152132445 0.492240680236478 2.0 -0.678552480038114 0.207672815509816 0.808329713896553 0.0953597502208484 0.12977723385844 0.813980172477613 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01982 -0.442293652363179 0.439675133141015 0.774714628788857 -0.316160502777873 0.584734550440081 0.83427397074951 False False False False False False False 0 insufficient_or_context_specific +EIF4ENIF1 -0.144929696373773 0.439750170942011 0.774717554614676 -0.174675640379852 0.345448779732879 0.691144142244059 0.176207568622545 0.671056281762475 -0.120637303569784 0.710073618045222 0.0555702650527613 0.889659988190431 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LHX2 -0.381028503665085 0.440036765841187 0.775050832527247 -0.461191076189385 0.34670048912225 0.691828343253207 0.459667011831189 1.0 -0.278380500789935 0.445370591747454 0.364526388580731 0.232816498500409 0.0861458877907959 0.810390171286346 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLEKHO1 0.203709236453671 0.440247638012474 0.775205897621031 -0.245574196661954 0.384153532163617 0.719298323474503 0.586433691055506 0.217181565983641 -0.680988060228178 0.0935082941601426 -0.0945543691726722 0.855817166348701 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLCD1 -0.232613385701577 0.440482966962754 0.775222968743735 -0.038927124557566 0.899073143171225 0.967837995533705 1.00200209048624 1.0 0.443825569609293 0.347766637176943 -0.36003275679543 0.348013797168114 0.0837928128138639 0.868106837595742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XRCC5 -0.110865586695812 0.440565954559606 0.775222968743735 -0.0619762419672984 0.667522621419401 0.875419277100913 0.0922296609059001 1.0 0.0462872353552164 0.918658847405116 0.170729930667157 0.562538198444062 0.217017166022374 0.507979726353779 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDX60L -0.177479366182379 0.440691636001399 0.775222968743735 -0.019244393378876 0.933541235477137 0.981304144333413 False False False False False False False 0 insufficient_or_context_specific +OSBPL10 0.171026147968379 0.440810131360702 0.775222968743735 0.199931133032287 0.366347796135508 0.707887999926555 -1.06183437232484 0.230131009004711 -1.02891959929376 0.250750124028506 -2.0907539716186 0.0350212285155975 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CAVIN1 -0.225236570456485 0.440881429030824 0.775222968743735 -0.116873167678986 0.697076000521381 0.888803059281445 1.45114442174419 1.0 -0.2758659714399 0.432427606147124 0.373595643772217 0.207060467961574 0.0977296723323176 0.776389417451801 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZRSR2 0.198528862310261 0.441233875635896 0.775648894266366 -0.200281866186358 0.437174373288364 0.754357618759665 -0.119996238389092 0.765446358163241 -0.789323788786623 0.02121162404756 -0.909320027175716 0.0170274726711647 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF595 0.121405798836654 0.441770236360476 0.775994730998025 0.0596181708958329 0.704477081281198 0.89229234871308 True False False False False False False 0 insufficient_or_context_specific +TTC21B 0.113210225571594 0.441787189212693 0.775994730998025 0.171107086815 0.236670872488367 0.605329180588419 -0.228879918993361 0.646455851798113 -0.203866032439263 0.602538512687415 -0.432745951432624 0.302492917389678 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF439 0.201207669684121 0.441837488097954 0.775994730998025 0.0568169812221053 0.825865159831465 0.941799403424202 True False False False False False False 0 insufficient_or_context_specific +MINDY2 0.205160620516037 0.441924067070701 0.775994730998025 -0.059289422438665 0.824148837887727 0.940484590404088 -0.214891255363192 0.449875487462527 0.346177919649576 0.135341054517724 0.131286664286385 0.613451542738169 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF577 0.227365038583292 0.442234374745363 0.775994730998025 0.137805858487124 0.640428325296286 0.864640237429136 True False False False False False False 0 insufficient_or_context_specific +TRIM4 0.133014099159634 0.442247750112833 0.775994730998025 0.105869563160511 0.541131161731805 0.813507447752299 0.256646123622109 1.0 True False False False False False False 0 insufficient_or_context_specific +EPB41L2 -0.179833171982539 0.442319286665128 0.775994730998025 0.0073279756020534 0.974519186996301 0.992488462764126 0.9676173175265551 0.103974946614854 2.0 0.289900084717171 0.362353530898824 -0.332040028334744 0.223645663668169 -0.0421399436175728 0.900371241016553 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APOO 0.194856312893892 0.442360863080352 0.775994730998025 0.0877665115728663 0.733402469791229 0.904481167627122 True False False False False False False 0 insufficient_or_context_specific +SNX19 0.189713558629698 0.442363384310072 0.775994730998025 0.203789011796787 0.408657631827626 0.734801770489731 0.418350225687695 0.285162053869031 2.0 -0.0860417331696175 0.789570833058506 0.13083440203712 0.584238734450044 0.044792668867502 0.87806910851411 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RRP7A -0.237749343596292 0.442382169052696 0.775994730998025 -0.336226160077424 0.269660290911782 0.634374632675266 0.16734652544342 0.768683455786331 2.0 False False False False False False False 0 insufficient_or_context_specific +CASP4 0.182080120735859 0.442433428226074 0.775994730998025 0.141224280591296 0.553965891262896 0.819759396393367 -0.434221267518182 0.506378482475533 -0.787993269277024 0.157454837192185 -1.22221453679521 0.0501748856705266 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DNAH2 0.267817489042412 0.442506266402458 0.775994730998025 0.34325395578901 0.327357439570242 0.676889991422347 True False False False False False False 0 insufficient_or_context_specific +SPATA20 -0.30883303062996 0.442646236942714 0.775994730998025 -0.263952714556378 0.514277651818099 0.798491683514042 False False False False False False False 0 insufficient_or_context_specific +RAB20 -0.357531183043724 0.442852287103369 0.775994730998025 -0.729403647616628 0.104297722640829 0.480701786460493 -0.461921548692835 0.233658535785586 0.393023863117014 0.231785235316527 -0.0688976855758209 0.86462666470178 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GGT7 -0.190527247259914 0.443055859376142 0.775994730998025 -0.282610301155866 0.245846516486118 0.611033451076589 0.260962392412881 0.579312487844748 -1.02839474601679 0.0175973677114717 -0.767432353603909 0.0799084864267494 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NCR3LG1 -0.341645989107997 0.443091875910403 0.775994730998025 -0.234712657549579 0.60623824271458 0.846931578987574 0.315157915130329 1.0 False False False False False False False 0 insufficient_or_context_specific +SAP130 -0.151713641511972 0.443115298992229 0.775994730998025 -0.0099582101370855 0.960312610303765 0.988836580730567 -0.0411212750585111 0.919893395448581 0.14946248287781 0.586226625579558 0.108341207819299 0.731838353880848 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OGFR -0.205345452464721 0.443172747838735 0.775994730998025 -0.256452350969926 0.340922912078869 0.688566111304456 0.0852698743957911 0.784039873542692 -0.15716954517039 0.497231608911154 -0.0718996707745988 0.790663895665047 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LYST -0.145922781931394 0.443189201642611 0.775994730998025 -0.0203404085139019 0.912980100297986 0.973464340430836 0.4306875898090129 1.0 -0.292263807143108 0.386717807038955 -0.345040061914851 0.231734487087436 -0.63730386905796 0.0491286738643093 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ETF1 -0.21796368582441 0.443302569966213 0.775994730998025 -0.329759373419025 0.246979396883659 0.612402177618055 -0.163793982017694 0.697149339533581 0.247452525138513 0.434170859625625 0.083658543120819 0.827325848895989 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC125 -0.233789900623395 0.443436734556089 0.776032660938702 -0.249850802086623 0.412426008227115 0.735291083225579 -0.507824506252379 0.221094369266366 -0.657541607630422 0.088346677370223 -1.1653661138828 0.01475632710262 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXO21 0.174727373417998 0.443698970502502 0.776208657316836 -0.0195113943566931 0.927779986226093 0.979087152943213 -0.560486882853682 0.162500496557046 1.08076744061183 0.0095358814900854 0.520280557758147 0.154799513622228 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP2R5C 0.11435309397429 0.443797795833105 0.776208657316836 -0.0629676067276273 0.665324522949659 0.875081569913425 0.070446270196017 0.810274055069768 -0.0015016179087858 0.996065620952593 0.0689446522872312 0.780238176080744 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPF2 -0.170308126566271 0.443909420521893 0.776208657316836 -0.173159902209864 0.435777059987467 0.753451320678163 0.847283875075519 0.111983612852235 -0.562718743263311 0.168016979337271 0.284565131812208 0.597365950741381 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BAG4 -0.174948503177946 0.443937685796944 0.776208657316836 -0.18948281374665 0.404481798162379 0.732758892415649 0.489863777998099 1.0 -0.642114815274859 0.0773897446667143 0.847840429418733 0.013876209066282 0.205725614143874 0.529027644279046 reversed False False False False False False False 0 insufficient_or_context_specific +AK2 -0.170463080909341 0.44416329445326 0.776297129532532 -0.124107772832837 0.577628017494228 0.83075298180061 0.0126897501006289 0.981117342485003 0.0213539945880014 0.960006881901985 0.0340437446886302 0.939802624314014 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IGBP1 0.173373749399413 0.444176071178824 0.776297129532532 0.0181739257724131 0.937404956361507 0.982785938767188 0.430094884232668 1.0 -0.274616153160149 0.451053509040966 0.527234676599067 0.0846569228845549 0.252618523438917 0.427115677892275 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARHGAP12 0.115175001579675 0.444302443348961 0.776376582489855 0.285529530086142 0.050780880534067 0.408254884487698 0.317011090401099 0.9322410745877141 2.0 -0.21546326680467 0.457148437429949 -0.22263736737358 0.355651980273421 -0.43810063417825 0.0955152398689109 partial_or_other True False False False False False False 0 cross_species_direction_conflict +XPA 0.148454241167352 0.444517923096942 0.776449663385629 0.168276534659125 0.38511439360697 0.719652702248211 0.377631296207971 1.0 -0.0051968649549486 0.989165574768777 -0.405688099965346 0.113319981192221 -0.410884964920295 0.13169745483195 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC8A1-AS1 -0.28028102182164 0.44456773486199 0.776449663385629 0.168893586857696 0.65829491229512 0.871691185476023 False False False False False False False 0 insufficient_or_context_specific +SLC37A3 0.128041805096537 0.444631053687205 0.776449663385629 -0.081056127460305 0.620009350175144 0.854061416837891 0.389530108448834 1.0 0.347561645778118 0.235506430308991 -0.0169138012143339 0.952179584858255 0.330647844563785 0.220322059381443 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PAH -0.523530525754703 0.444741190222357 0.776482357748697 -0.373746213585654 0.586104169444474 0.835099570984448 -1.12593577481163 0.0184675309339623 1.61292315425973 0.003145437360199 0.486987379448104 0.232861347532524 reversed False False False False False False False 0 insufficient_or_context_specific +AC123768.3 0.205299155035674 0.444877124897974 0.776494079132552 0.293555501379751 0.281674372560099 0.64315368591277 True False False False False False False 0 insufficient_or_context_specific +TEFM 0.16709017032617 0.445035907636659 0.776642828566586 0.303251674406577 0.155265361175228 0.539558215777 -0.309176776514002 0.377614882022643 -0.0799663671586646 0.801730092400078 -0.389143143672667 0.218726361577926 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RNF34 -0.216533156904548 0.445309924789114 0.776908527534919 -0.367746090406202 0.170480971793151 0.5509452403404 -0.110140178951643 0.857861476753285 -0.53616051132926 0.209434770531013 -0.646300690280902 0.166910928539745 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TNRC6A 0.113131640226317 0.445335329479194 0.776908527534919 0.146545937147189 0.31835082699319 0.670352618945772 0.8429530969012691 0.140640050935703 2.0 -0.116021431257587 0.758527709956531 -0.0894803811970346 0.768348758550098 -0.205501812454622 0.500533801095079 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LZTR1 -0.164273333757658 0.445466271028719 0.777008572529526 0.0245855943181237 0.908115678550193 0.971404958566788 0.0757092541183925 0.809362291417351 -0.104690895251054 0.65257124852416 -0.0289816411326618 0.918249843470456 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC002070.1 0.428736149450098 0.445567130429791 0.777056122080894 0.152415369157775 0.772041649205414 0.920833227780249 True False False False False False False 0 insufficient_or_context_specific +SIRT1 -0.192911323710547 0.446117172812656 0.777806498888901 -0.159478701367437 0.52936126462351 0.806619797913863 0.165257503043321 0.642781738449557 -0.395444169460353 0.151341855412342 -0.230186666417032 0.45002220408002 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM122C -0.1985313028494 0.446555683341759 0.778137465707591 -0.277847733270599 0.282087215069375 0.64323473576915 False False False False False False False 0 insufficient_or_context_specific +ZNF334 -0.285092319551147 0.446746480591128 0.778213057594642 0.061671256124381 0.871829537559384 0.958683313195135 False False False False False False False 0 insufficient_or_context_specific +ANKRD36B -0.17291999905134 0.446930322234243 0.778277177701326 0.0467481736315618 0.837511639855284 0.94774361131748 False False False False False False False 0 insufficient_or_context_specific +RPL13A 0.209987775485572 0.446930718734906 0.778277177701326 0.443747335026663 0.102334126928663 0.479137456027696 0.8624439103240329 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF808 -0.206255632121087 0.447299170203084 0.778609336495366 -0.526106704797938 0.0360373132135544 0.37720666979567 False False False False False False False 0 insufficient_or_context_specific +ATXN7L3 -0.217506493310535 0.447349307248307 0.778609336495366 -0.159134843892891 0.582404778772303 0.833494998054781 0.410379213716062 0.433191136182332 2.0 0.110512910420314 0.733587945861234 -0.355972139616319 0.152884121419165 -0.245459229196005 0.351430376517966 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXW8 0.171086532305573 0.447546497394546 0.778609336495366 0.18348487052874 0.415689522000459 0.737532312785253 -0.005001387873014 0.987388076265519 -0.223804603089734 0.278250664043793 -0.228805990962748 0.294687769269735 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MT-CO3 -0.171968224769528 0.447743166624869 0.778609336495366 -0.160631330873184 0.478104838018094 0.778545319644225 0.0473196366134851 1.0 -0.756001903195318 0.107152681960269 0.371251628856113 0.370084756298334 -0.384750274339205 0.372951020898835 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPARGC1A 0.417933029716501 0.447765544703298 0.778609336495366 0.33810581370489 0.540976674562151 0.813507447752299 0.830444607674213 0.5359925116792701 2.0 -0.575263368387766 0.426737081292997 -0.0544870320111411 0.937951091658225 -0.629750400398907 0.329244082461599 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AAR2 0.254650416842351 0.447869526929198 0.778609336495366 0.263039584305124 0.434239941147331 0.751847362038176 -0.0941707744580717 0.868900513081839 0.196587089962217 0.60261595367315 0.102416315504145 0.825574332282047 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SPTLC3 -0.23558466679651 0.447925589918893 0.778609336495366 -0.176186274886859 0.569763842284533 0.825998098341687 False False False False False False False 0 insufficient_or_context_specific +ZNF512 0.144513705507306 0.447932668106919 0.778609336495366 0.232868478610769 0.215665167629001 0.587852789707652 0.524600880451199 1.0 True False False False False False False 0 insufficient_or_context_specific +CKMT2-AS1 0.147751982500329 0.448019028862903 0.778631260367823 0.10907162421659 0.580121638515363 0.832343230477465 True False False False False False False 0 insufficient_or_context_specific +P4HA2 -0.166853502153469 0.448229764077889 0.778763723220289 0.156311477532576 0.500514004808796 0.790819493321426 0.28146050089649 0.44416359724533 -0.296478822152316 0.325181167526482 -0.0150183212558263 0.969955408199307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLA2G4C 0.295102284127912 0.448349324014031 0.778763723220289 0.333881339975274 0.389442669967088 0.722218665388488 0.122901002693986 1.0 True False False False False False False 0 insufficient_or_context_specific +APCS -0.280297720289678 0.448586686738083 0.778763723220289 -0.281568264418135 0.446838813972646 0.761469121135878 -1.76486476554997 0.0262046998616491 0.778891793594013 0.239891024691281 -0.985972971955959 0.149736646702647 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE2G1 -0.145890757893554 0.448620425603992 0.778763723220289 0.0541475636404059 0.778737455334641 0.922929913000972 -0.141200500117664 0.572275690773135 0.444750378551003 0.0375916467349194 0.303549878433339 0.152342318401543 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HLA-DRA 0.470024453814693 0.44864263749668 0.778763723220289 0.474475604213886 0.445507344887097 0.760927015161427 True False False False False False False 0 insufficient_or_context_specific +DNAJC10 -0.163260681544844 0.448685331345806 0.778763723220289 -0.0305580625098175 0.88683977008266 0.963622568156774 0.254120120757059 0.322611567357763 -0.355368650234332 0.113586287781897 -0.101248529477272 0.688030642577983 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VGLL4 0.144141375744793 0.44880281687716 0.778815401151015 0.315864578283161 0.0876062210680477 0.468622105620855 0.189720330717869 0.882842789689247 2.0 -0.367037863008215 0.168923844668647 0.148920917047409 0.529911393705376 -0.218116945960806 0.375460480088534 partial_or_other True False False False False False False 0 cross_species_direction_conflict +POLE2 -0.234276267539689 0.448990130996305 0.778815401151015 0.0067394661890604 0.98398610795014 0.99451887511202 0.822355686498751 0.268511291264226 -1.76851596100398 0.016664800210118 -0.946160274505229 0.240355283202405 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCML1 0.129485160977845 0.449015862506367 0.778815401151015 0.0578161667220082 0.733301645967051 0.904481167627122 True False False False False False False 0 insufficient_or_context_specific +TSPYL2 -0.247595231121751 0.449201377442348 0.778891138616572 -0.659036849133278 0.0238028670929343 0.348898908348731 -0.157468533465866 0.69012037780104 -0.742829140187538 0.0302254694531734 -0.900297673653404 0.0186172435005488 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EYA2 0.376148313064649 0.449630518225965 0.779382745151438 0.119483039457878 0.804464893519919 0.931820114732123 True False False False False False False 0 insufficient_or_context_specific +TMEM200A 0.612949048894084 0.449632534638891 0.779382745151438 0.981803134049297 0.227821459168282 0.600160304082166 0.0884861489134739 1.0 True False False False False False False 0 insufficient_or_context_specific +DHRS4-AS1 0.241876057971331 0.449883737865858 0.779690168152943 0.189303787270137 0.558648622423746 0.821592444010296 True False False False False False False 0 insufficient_or_context_specific +UST -0.187858068432698 0.450041353893686 0.779786184340346 -0.0229712628400211 0.925563853126981 0.978485542437683 0.238588866242034 0.649396864323625 -0.300735729490731 0.454436027589302 -0.0621468632486972 0.904988058389608 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ELMO1 -0.2985841985311 0.450251040678521 0.779786184340346 -0.405362760539683 0.300872593133606 0.658632920234719 0.418127272476807 0.625964781177344 2.0 0.323154504642946 0.598265111036185 -0.0317172520238632 0.952179584858255 0.291437252619083 0.591123721088833 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC02328 0.277533492102181 0.450312769275466 0.779786184340346 0.426696027734119 0.251476051377043 0.618324208299677 True False False False False False False 0 insufficient_or_context_specific +SCYL1 -0.16677801755884 0.450347961663798 0.779786184340346 -0.0642806548445911 0.771165653713905 0.920641521976153 0.283878123587508 1.0 0.262417478855728 0.283908827216658 -0.25695561570113 0.221306890614896 0.005461863154598 0.984914814547429 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OSGEP -0.197067493080332 0.450408671421944 0.779786184340346 -0.261968558503727 0.310989075471955 0.66386306487225 0.376503064941704 0.301231745724493 0.0694577993152939 0.828749847998863 0.445960864256998 0.178974178186747 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXW2 0.141499277675443 0.450422933357181 0.779786184340346 0.312054088005384 0.0907971116337918 0.472234212482528 -0.233822382225471 0.431480210698407 0.303076952629089 0.216866411624609 0.069254570403618 0.812897329536746 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ANGPTL8 -0.389863317576442 0.450510265822149 0.779786184340346 0.0171117589877343 0.972475306352203 0.992040338141303 1.35381498932872 0.0426721261531328 -0.895941093765879 0.106707306604357 0.45787389556284 0.455619430297874 reversed False False False False False False False 0 insufficient_or_context_specific +DNAJB12 -0.188316624224234 0.450529998529656 0.779786184340346 -0.278046652223406 0.261069532865559 0.623754724597097 0.7935532086501059 0.485806502228287 2.0 -0.213683417604224 0.44416359724533 0.573136493970127 0.0257817665321188 0.359453076365903 0.144991016328937 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WEE2-AS1 0.321208955656862 0.450608747139719 0.779794648795468 0.401764646397732 0.349585724775999 0.694305132088977 True False False False False False False 0 insufficient_or_context_specific +SELP -0.404315576227907 0.450918294269561 0.780202450163558 -0.243717666945039 0.654193253326417 0.870882911186523 False False False False False False False 0 insufficient_or_context_specific +NUDT4 0.187001950201706 0.451292473635748 0.780593309593334 -0.0722262084039356 0.774608936241801 0.921907331897703 0.04499358911650701 1.0 0.137432142262 0.726514481255491 -0.247089446575666 0.413907229381968 -0.109657304313667 0.753709228025145 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF330 -0.218911383734021 0.45145053735635 0.780593309593334 -0.352073605648534 0.220104407096606 0.59217704709374 False False False False False False False 0 insufficient_or_context_specific +SUSD6 0.160006886489456 0.451471710752075 0.780593309593334 0.243755983962152 0.245648891204084 0.611033451076589 -0.179303018680374 0.591573875748349 0.0603236581702601 0.840127847163831 -0.118979360510114 0.696305383272471 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLEKHB2 0.188448594952573 0.451825249605564 0.780875918372163 -0.0178136360017065 0.943019373923185 0.984366565940656 -0.891527883056017 0.0299525668371215 0.369642857496514 0.28369828219139 -0.521885025559503 0.149841324160335 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EXPH5 -0.49139620537313 0.452177459542895 0.78122886890098 -0.288426052133294 0.665717006420308 0.87511808324756 -1.02042327300906 0.0826749741133801 1.07427291083016 0.0398324242259432 0.0538496378210953 0.927489221408977 reversed False False False False False False False 0 insufficient_or_context_specific +PEPD -0.364620845635694 0.452333357999244 0.781242531286769 -0.4411797727967 0.361042869539682 0.703177809506737 0.0407590773275656 0.917945009132389 0.132836376602921 0.622278168283253 0.173595453930487 0.54931278288843 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LARS -0.141274467255052 0.452615164784008 0.781361739217937 0.004749957719493 0.980179351311941 0.994014064108846 0.0589016606438023 1.0 0.163404177070682 0.48854123559709 -0.320341912322679 0.104348830690824 -0.156937735251997 0.453788689222916 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RHOT1 -0.110889465423448 0.452781784923712 0.781361739217937 0.0358070514869262 0.81710785829012 0.936371599889798 0.819368316771619 1.0 0.233100938382893 0.377009430087264 -0.133866535796797 0.550717539478891 0.099234402586096 0.699277372315085 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SESN2 -0.248995858910791 0.452818963072729 0.781361739217937 -0.366073235966838 0.257873724785564 0.621906676979798 0.595755785523381 1.0 0.905511212199371 0.0780196205994132 -0.293759601053928 0.451140330448465 0.611751611145443 0.204608298321739 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AVEN -0.181029648518806 0.452894013145458 0.781361739217937 -0.0906861295703828 0.706648530931047 0.892997076377691 -0.949433380731724 0.0103461786531277 0.861423103913111 0.0115855588156646 -0.088010276818613 0.79223875760129 reversed False False False False False False False 0 insufficient_or_context_specific +TAMM41 0.14649741849099 0.453021100058387 0.781361739217937 0.0364633457269432 0.849914476127959 0.953127856970211 -0.101079199731275 0.894918337001702 -1.05249142104581 0.0631027379832014 -1.15357062077709 0.0695828327445302 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM45B 0.567483172549704 0.453364512438136 0.781703791703294 0.194224230489529 0.783598236164119 0.925090291650546 True False False False False False False 0 insufficient_or_context_specific +GNL2 -0.183816801266675 0.453662370400198 0.781875172491885 -0.28751335206691 0.236755488771598 0.605329180588419 0.260082911076222 1.0 0.083598259145677 0.843696053451533 -0.19141611412488 0.515599073162639 -0.107817854979203 0.75711399888088 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC018816.1 0.265006113215098 0.453741268999891 0.781883518541022 0.370279228023454 0.299014976368413 0.657023958480272 True False False False False False False 0 insufficient_or_context_specific +AIFM1 -0.196463648807285 0.453935822596636 0.781963520146073 -0.0220404990852672 0.932564309427639 0.981045440677165 0.372872467831829 1.0 -0.0714476390068401 0.864077958896805 0.360193928382294 0.208101365811055 0.288746289375454 0.344035585190447 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PID1 0.303377277417372 0.454174931063842 0.782149616364405 0.184740501018959 0.650604578921076 0.869901306439436 0.655272813548417 1.0 -0.536171876167706 0.140425844767417 0.540323360201456 0.09815875781029 0.0041514840337496 0.992314187468256 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GRINA -0.275802271186454 0.454192015337201 0.782149616364405 -0.341842200120153 0.3447121847841 0.69073818751447 0.465543856810182 1.0 -0.16756979942785 0.534206929618323 0.162029166951404 0.466593234166156 -0.0055406324764453 0.985328980599841 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL10A 0.232615848131041 0.454372963830706 0.782206057740843 0.115427999860866 0.711401243899005 0.895438659850091 True False False False False False False 0 insufficient_or_context_specific +EXOC3L4 -0.237216700636219 0.454864586653991 0.782797115874953 -0.0811763666596361 0.795794480767015 0.928705441354941 0.132641784654351 1.0 1.12815966588114 0.0245453240767794 -0.96340158998273 0.0265330988034598 0.164758075898408 0.743431515337965 reversed False False False False False False False 0 insufficient_or_context_specific +SFMBT2 0.217725101806388 0.455268813673854 0.783365080633727 0.0523180879072777 0.854043751813075 0.95526155065304 0.476668572027231 1.0 -0.882027188825799 0.273884669019804 -1.32661736267785 0.117457705498441 -2.20864455150365 0.0233142909546514 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HLA-DRB5 0.50123638273393 0.455404969347208 0.783471674493697 0.479904193986181 0.476528130287611 0.778118997654425 True False False False False False False 0 insufficient_or_context_specific +ZXDC -0.13734587061758 0.45559589792745 0.783672448732162 -0.280304457908833 0.102516718428354 0.479137456027696 0.3286450205692381 0.6255979841489999 2.0 0.0997071857828496 0.797189358910681 0.191281300260826 0.484876296668573 0.290988486043676 0.327323901632302 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC44A2 -0.24357915467827 0.455794359512889 0.783678185217199 -0.488489507838572 0.10878288088168 0.485176912870447 0.361407734386038 0.127466330598942 -0.40720566098172 0.0604351196850955 -0.0457979265956822 0.856160220125205 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGAP1 -0.136673737745243 0.455838921712712 0.783678185217199 -0.241378401833178 0.183752626985209 0.565716727964854 0.877834614173504 1.0 0.575732116966635 0.0627301623358899 -0.207657928381524 0.420122371101311 0.368074188585111 0.193822604013931 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AARS -0.165505820410322 0.455891398456279 0.783678185217199 -0.0447513041031552 0.842591836984967 0.950469545398617 -0.349858343460348 0.237880289162034 0.604088808839603 0.0321191149160154 0.254230465379255 0.348225573108413 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBAC2 0.12174979027356 0.456020044813635 0.783678185217199 0.194521880528195 0.215809548942608 0.587852789707652 -0.0155899240105252 0.967369473703438 0.418618171387943 0.102354593066032 0.403028247377417 0.141727446607445 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BCL2L13 -0.125541444280755 0.456044588934881 0.783678185217199 -0.253574927377323 0.111823936052059 0.490094278471416 0.535088566103424 1.0 -0.0035889010862286 0.992788933773383 0.0336016170301558 0.902660460420492 0.0300127159439271 0.919617016326102 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NDFIP1 0.138417231323412 0.456165586073599 0.783758544794965 0.216463317433752 0.248583225376135 0.614215233681543 -0.281126367120395 0.510926162121537 0.752141174884365 0.046409360022858 0.47101480776397 0.201833682859162 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PHYKPL -0.130743467592098 0.456718752914872 0.784581287548847 -0.105046891649727 0.549039560901381 0.816365047001981 0.0983479630848216 0.868988931722344 -0.743934674782574 0.0797360446209067 -0.645586711697752 0.165677366715146 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTA3 0.138064406232263 0.456891270243438 0.784735347133062 0.161908240113627 0.382641128989083 0.718507811674046 -0.144861342248398 0.654324876820307 -0.210449657036807 0.409038535160577 -0.355310999285205 0.187156648302077 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RFC2 -0.24906889302151 0.456984168414164 0.784735347133062 -0.373378691373703 0.257178076584606 0.621906676979798 -0.0218476895631906 0.95834264814358 -0.0200651097481379 0.951090818282522 -0.0419127993113285 0.907060387788551 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP3CB -0.102133266933149 0.457101343902053 0.784735347133062 -0.189910251170699 0.151625439516018 0.534332907346501 0.36327833591928 0.189244164338537 -0.197059916444038 0.411368029427231 0.166218419475242 0.530081663735485 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BSDC1 0.173259968727749 0.457105738290238 0.784735347133062 0.0159987186494869 0.946409575111642 0.985520494528919 0.33477738312463 1.0 -0.243399108257737 0.377317949762389 0.169235014156744 0.47344553173044 -0.0741640941009932 0.787124818037656 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SYK 0.491042068068664 0.457596798952445 0.785187011788209 -0.191177283173057 0.767655931039642 0.91965407011421 -0.887691104276724 0.266322330573583 -0.57050880564643 0.43574482263392 -1.45819990992315 0.0666817903362859 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NLGN1 0.346503517824976 0.457608595378232 0.785187011788209 0.602277593063343 0.194472174726418 0.571343735852293 True False False False False False False 0 insufficient_or_context_specific +CREBL2 0.197089496932049 0.457837480005442 0.785187011788209 0.3399045146375 0.206608426624261 0.579535538867947 -0.833388333146285 0.0333595877111666 0.453028560485483 0.174553130714569 -0.380359772660801 0.269859160789868 reversed True False False False False False False 0 cross_species_direction_conflict +FAM91A1 -0.13026456227935 0.457970126253108 0.785187011788209 0.103900298114751 0.553055669204681 0.819071644755648 -0.0668990525370957 0.834111176420739 0.139412053526062 0.539056666971104 0.0725130009889659 0.78370087562633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFP30 0.167625266364349 0.458011976458078 0.785187011788209 0.209717923572703 0.354836343495166 0.698200328680699 -0.140079065885266 0.865601843682601 -0.0717546433766184 0.909448529459456 -0.211833709261884 0.752513714186864 partial_or_other True False False False False False False 0 cross_species_direction_conflict +INSR 0.223342882114461 0.458055404757055 0.785187011788209 -0.0975597492114137 0.741928571842329 0.908944286552716 0.3031470645652151 1.0 -0.187314268066492 0.591367743257789 0.394660130997123 0.158574999066464 0.207345862930631 0.487856877889904 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCLT1 -0.122101686327209 0.458064002298469 0.785187011788209 -0.140494127600596 0.392657153422406 0.72489495118618 -0.0992842149712735 0.790312262842653 -0.228002595553813 0.397576614491866 -0.327286810525086 0.26552257421949 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RASSF4 -0.348949471989844 0.458369304804872 0.785187011788209 -0.36778464788104 0.433755127953672 0.751660242498796 1.15450639466342 0.0551677043117529 2.0 -1.32211601796044 0.161451638814472 1.05703457648884 0.182245036169504 -0.265081441471596 0.758765293217368 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NSUN5 -0.261123406511393 0.458448859847082 0.785187011788209 -0.0190123972687542 0.957216787948537 0.987656798648419 -0.0640289536946269 0.834111176420739 -0.604271463791828 0.015457686141729 -0.668300417486455 0.0153776678202828 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TSPAN17 -0.290405327994672 0.458502259640549 0.785187011788209 -0.185458379174314 0.637952447247002 0.863120280388885 0.0989087895819676 1.0 -0.119125964456781 0.786453212704029 -0.506674905700159 0.124807360126234 -0.625800870156939 0.0825180787296332 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PMM2 0.161711011664598 0.458599980191698 0.785187011788209 0.260928783278226 0.232439933791856 0.602381153896519 0.138966586259864 0.0333664088315665 2.0 -0.0451051940285778 0.870704261056816 0.194447426054847 0.307315771456057 0.149342232026269 0.469535893076807 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC16A4 0.199545327380024 0.458697725385466 0.785187011788209 0.187820997199669 0.486786393202345 0.782147598778917 True False False False False False False 0 insufficient_or_context_specific +AC104123.1 0.207815741330645 0.458749556667166 0.785187011788209 0.076005247761359 0.790807481442514 0.92749893235615 True False False False False False False 0 insufficient_or_context_specific +UXS1 -0.272826916918727 0.458777293613241 0.785187011788209 0.129868244663621 0.721715988718415 0.901057712595039 0.0765150323279788 0.886337907728528 0.161381976341196 0.653564710558664 0.237897008669175 0.553928895319759 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAPK9 -0.133498794732544 0.458913907670328 0.785285743465692 0.0746500774983972 0.680358467644592 0.881048329971919 -0.0732109245480435 0.83289069999139 0.096057360591924 0.710240416469499 0.0228464360438804 0.940431634814982 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NCOA2 0.144872778525581 0.459311606843167 0.785651513174289 0.02855432375555 0.885087101570172 0.963081098449005 -0.402699712251574 0.0891643027210483 0.209001707617166 0.309931266350556 -0.193698004634408 0.373406397510707 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DHRSX -0.132268849966407 0.459445952877245 0.785651513174289 -0.233594204040175 0.185793405585157 0.56775396895769 False False False False False False False 0 insufficient_or_context_specific +PIK3C2G -0.441495336052708 0.459596612412336 0.785651513174289 -0.69800349102642 0.237436701285825 0.605329180588419 0.42330456467371 1.0 -0.654104672455918 0.172866202816366 -0.0963308975689548 0.836543207084056 -0.750435570024873 0.0999722639556884 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NPAP1 0.398029876019974 0.459603309511279 0.785651513174289 0.503492242628873 0.3531156532726 0.697119496494411 True False False False False False False 0 insufficient_or_context_specific +ARG1 -0.54445616709527 0.459684994831818 0.785651513174289 -0.709070184346026 0.333980217420582 0.683762485073978 -0.635361796613557 0.173675376324629 0.596411049117437 0.152696742184117 -0.0389507474961203 0.938502922811403 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MANF -0.307382825015542 0.459930056670747 0.785651513174289 -0.339068891961265 0.414959310366615 0.737069380694939 0.0106144906153785 1.0 -0.484304471713524 0.328405226703497 0.918236789256729 0.0457088994865006 0.433932317543205 0.332446343440499 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR37 -0.116491990071477 0.460091525553408 0.785651513174289 -0.285510742719612 0.0681867731502207 0.438244764077482 -0.0281786691805119 0.961509654240006 -0.353155694273755 0.372505596882872 -0.381334363454267 0.371016168204809 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIK3R5 0.311092810929503 0.460095028031505 0.785651513174289 -0.20490478501219 0.600940947780671 0.84360251650955 False False False False False False False 0 insufficient_or_context_specific +RB1 -0.101277415661965 0.460195587153703 0.785696152841008 0.0337116824987853 0.81353300121327 0.93504043400933 0.344541223170134 0.268315381684124 -0.135291919344081 0.611526072358054 0.209249303826054 0.470920002622069 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OVCH1-AS1 0.551270213940241 0.460528135262134 0.786136790961619 -0.165939001859615 0.820006702799092 0.937784961888303 0.005157977169786471 1.0 False False False False False False False 0 insufficient_or_context_specific +ADAMTS9 -0.358514945199934 0.460648579393229 0.786209890498392 -0.455795130510508 0.351536208596804 0.695960310851161 0.450219918738714 1.0 0.54367110792235 0.268192648474292 -0.744914158124024 0.0899014843061525 -0.201243050201674 0.678208049807557 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NLK 0.135005174831127 0.460827736981731 0.786209890498392 0.300256058258734 0.100628202257896 0.478142465994088 0.266777639813951 0.455787878137711 2.0 -0.0679113528513305 0.885312885080925 -0.0563900926911721 0.877545768120053 -0.124301445542502 0.739564849239821 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MOCS1 0.202645347823787 0.460871690303865 0.786209890498392 -0.0096865056852219 0.97165238674233 0.992040338141303 1.10840144939239 1.0 -0.808174278661924 0.0080989648790917 0.451651269039153 0.0708071440122557 -0.356523009622771 0.156824084499146 reversed False False False False False False False 0 insufficient_or_context_specific +AC011477.4 0.222120411448055 0.460943286814269 0.786209890498392 -0.168646374401485 0.561750738232206 0.823291102966203 False False False False False False False 0 insufficient_or_context_specific +PDE4A -0.202590888426352 0.461143268909615 0.786296936877861 -0.0894298996753367 0.745648867606323 0.909628867935198 0.366193105601197 0.373489286461498 -0.563823643801837 0.108559073268397 -0.197630538200641 0.6158824562202 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CPM -0.41598370393015 0.461240430438777 0.78633561514171 -0.730254390959394 0.188666816548649 0.569351952070621 False False False False False False False 0 insufficient_or_context_specific +HLA-E 0.215610609853701 0.461379117543181 0.786445063451873 0.25359589825367 0.384706050622902 0.719398951908714 True False False False False False False 0 insufficient_or_context_specific +FMO4 0.237664480042136 0.461710769425954 0.786536199487743 0.0509694568324971 0.873403665464845 0.959263070839262 0.167264295185834 1.0 True False False False False False False 0 insufficient_or_context_specific +ABHD18 -0.12698241221838 0.461716385978816 0.786536199487743 -0.168368802517297 0.331475323291337 0.680349234702553 -0.34339818044565 0.450274854573042 0.225837975391385 0.537385612990621 -0.117560205054265 0.788756958774337 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEC24A -0.127999975613127 0.462089743721023 0.786826394654489 0.0768599592854554 0.658030063532612 0.871691185476023 -0.343131889532817 0.31546451949508 0.350657175234247 0.229275263938392 0.0075252857014297 0.984914814547429 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLR2E -0.265178606883676 0.462150597099658 0.786826394654489 -0.416684121676109 0.246214949823564 0.611463774743042 -0.255247777266427 0.367071254441278 0.124629097810265 0.615529226422344 -0.130618679456162 0.626082439253009 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TACC1 0.269395078737116 0.462199024403025 0.786826394654489 -0.129561000020051 0.715449661372623 0.897313488883515 0.229418825820179 0.0987593765405206 2.0 -0.0297026914913172 0.931049044353546 0.0301990018765721 0.910476463165681 0.0004963103852549 0.998984281818503 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MSH4 -0.345027289812067 0.462698045593782 0.787421980235195 -0.258214259902127 0.585815882473992 0.83502769041167 False False False False False False False 0 insufficient_or_context_specific +MACF1 -0.17711827900035 0.462836687009755 0.78748306516316 -0.344772159541954 0.134777347903942 0.521613530841394 0.791564076399646 0.9654248431410791 2.0 0.253951640204442 0.411025827148292 -0.318351556534237 0.226083959377715 -0.0643999163297952 0.836954914089241 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF486 0.264490276880719 0.46288311255944 0.78748306516316 0.286111618809998 0.428919479274577 0.748336221434264 True False False False False False False 0 insufficient_or_context_specific +PIP5K1C -0.21309500156047 0.463150629862109 0.787811237326268 -0.372345504579384 0.189875772946457 0.569886897607216 0.8293451109375441 1.0 0.217268143754268 0.430234691839864 -0.213271568626002 0.354550749302944 0.0039965751282657 0.989116554816934 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLS2 -0.487193614544284 0.463309229182715 0.787954065997279 -0.445559553359062 0.504349921936884 0.792758405693685 -0.635352155411983 0.182303538601032 1.18639752473339 0.0144032326698679 0.551045369321407 0.204608298321739 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLAIN2 0.138364881037366 0.463456811449289 0.788053563778485 0.246482935364739 0.194786388964694 0.571343735852293 -0.0996316698485968 0.781810193990744 0.146974099751521 0.580326354529091 0.0473424299029242 0.885032422574932 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GEMIN8 0.200326590120937 0.463696373722828 0.788053563778485 0.16028651042029 0.559211257073943 0.821846488287693 -0.67073424504967 0.33542535927571 1.14809072857424 0.0386019497383689 0.477356483524573 0.395188806077642 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PXN 0.133644396326238 0.464004530493094 0.788053563778485 0.106117028503131 0.560859202482153 0.822780527970901 0.8590201325222411 1.0 -0.0399775549886876 0.894159349094376 0.0412039174258315 0.857046459113568 0.0012263624371439 0.996706572185061 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C3ORF38 0.221764184103492 0.464019076033437 0.788053563778485 0.298370983339784 0.325732001000097 0.675077178818285 True False False False False False False 0 insufficient_or_context_specific +AC068631.1 -0.305361546568192 0.464137225870966 0.788053563778485 -0.297790838917022 0.476830370776935 0.778277819446707 False False False False False False False 0 insufficient_or_context_specific +LINC01320 0.522098711461996 0.464242926060054 0.788053563778485 0.356006954818918 0.609596029814693 0.848013066172034 True False False False False False False 0 insufficient_or_context_specific +ANGPTL3 0.345689578584037 0.464359573814013 0.788053563778485 0.442184194329062 0.35173608472799 0.696018164443657 0.985442218836238 1.0 -0.293433718031227 0.665942220238059 0.849772313635069 0.11836793546369 0.556338595603842 0.318814162767615 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CROT -0.188327871594051 0.464397576059663 0.788053563778485 -0.106658628883731 0.677851227952154 0.879886294337383 -0.95750340847823 0.0349677412085669 1.13525858711491 0.0123956087144163 0.17775517863668 0.678841505887135 reversed False False False False False False False 0 insufficient_or_context_specific +GNG2 -0.444315082542711 0.464434165824167 0.788053563778485 -0.0412084258675868 0.946232091035419 0.985432868134933 -0.679626417912697 0.248083775024392 0.692160069788329 0.143670338277104 0.0125336518756319 0.984896167445403 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCP11L2 0.259705815855015 0.464659526951705 0.788092415350377 0.0155328988763194 0.965066053865533 0.990502597656486 -0.284536042273206 0.459451649292564 0.695320788213896 0.0394463580733521 0.410784745940689 0.217298011044801 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CAMLG -0.192882068593779 0.465036662095931 0.788605377193839 -0.0768478873787561 0.773730236227962 0.921597905470986 False False False False False False False 0 insufficient_or_context_specific +PLRG1 -0.153043995038585 0.465308448665683 0.788812877490732 -0.0873580801382146 0.672203386717143 0.877133430257505 0.0449466164154739 0.913404250610453 0.331288956971078 0.208101365811055 0.376235573386552 0.193494492752306 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPRC5D-AS1 -0.265995343554453 0.465475317755731 0.788860103718504 0.158947216554523 0.674019695378428 0.877796958653688 False False False False False False False 0 insufficient_or_context_specific +ZNF616 -0.228671325291354 0.465485740307471 0.788860103718504 -0.0243855030907927 0.941049148084832 0.984111856389759 False False False False False False False 0 insufficient_or_context_specific +ZNF141 0.13564311401966 0.465835199193758 0.788952759414185 -0.060835878367375 0.752804892936409 0.913156486629435 False False False False False False False 0 insufficient_or_context_specific +SPSB3 -0.249700824945449 0.465905649313704 0.788952759414185 -0.378142398904722 0.257736252335921 0.621906676979798 0.439332479201979 1.0 0.274704012180453 0.35075887343145 -0.08239456024859 0.752634238910344 0.192309451931863 0.478523063725881 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNOT9 -0.173494152373185 0.466142692908696 0.788952759414185 -0.278736414462456 0.238858080840738 0.606415397271769 0.0459913757563977 0.915993062050496 0.0390271369444192 0.90401365135368 0.0850185127008169 0.803575174629423 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBA52 0.22871333829413 0.466149846213666 0.788952759414185 0.380740170632256 0.219178439300849 0.591837841979121 0.366391223907789 1.0 True False False False False False False 0 insufficient_or_context_specific +ISG20L2 -0.167273945197187 0.466214193595899 0.788952759414185 -0.154734794353014 0.500210365274395 0.790819493321426 -0.130637151633968 0.811157336781858 0.373100043691452 0.308624631277282 0.242462892057484 0.56558331736643 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FDX1 -0.202344108001171 0.466228278371815 0.788952759414185 -0.119137097409144 0.669780635165682 0.876275581918126 -0.566908583720969 0.202251003573422 0.758889310722773 0.0630284000043956 0.191980727001804 0.657841427737301 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCMTD2 0.188288029713285 0.466239120599332 0.788952759414185 0.043294362488853 0.867072687093703 0.958391272020028 -0.175500014154269 0.645702577553322 -0.0722609032665506 0.825674648135477 -0.247760917420819 0.438816575365308 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRPS16 -0.19271805982007 0.466311685545597 0.788952759414185 0.0252558544558175 0.927575340061564 0.979087152943213 False False False False False False False 0 insufficient_or_context_specific +FAM133B 0.113770695246566 0.466461465513284 0.788952759414185 -0.0745776126948242 0.64984792917529 0.869593718153702 0.3387930368953679 1.0 -0.322348045305183 0.434728267741181 -0.301661877730944 0.381989561295581 -0.624009923036128 0.0999940942766206 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DGKG -0.481173791139416 0.466473439188597 0.788952759414185 -0.632657834454739 0.335558389867069 0.684461073909613 False False False False False False False 0 insufficient_or_context_specific +MYO1B -0.157995206775986 0.466511846658719 0.788952759414185 -0.134726249901822 0.533455050936146 0.810158001695028 0.330152929278544 0.376195538966002 2.0 -0.550831807496212 0.0674388078975907 0.281844592425814 0.28369828219139 -0.268987215070398 0.327460978100806 reversed False False False False False False False 0 insufficient_or_context_specific +PES1 -0.267122784017831 0.466852708707536 0.789276364857353 -0.301959606161149 0.409828490381809 0.735004110999004 0.882281771373159 0.572704414489141 2.0 False False False False False False False 0 insufficient_or_context_specific +LZTS2 -0.195516212739978 0.46725514027601 0.789830254728484 -0.0112576407080673 0.967906986190438 0.991065707083724 0.474795569202084 0.0873881031794798 -0.693828621049627 0.0139573704372748 -0.219033051847543 0.396494290562899 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HMGCR -0.249607681456707 0.46746684458503 0.789891845674348 -0.395756688422737 0.237143381234239 0.605329180588419 0.340861266636734 0.36951333282411 -0.24040250238073 0.450742298666477 0.100458764256004 0.792871789850276 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRERF1 -0.25805799823331 0.467598561837229 0.789891845674348 -0.044975936745479 0.899295261281855 0.967837995533705 0.5571028748864039 1.0 False False False False False False False 0 insufficient_or_context_specific +TBC1D22A -0.10040969267156 0.46766564948952 0.789891845674348 -0.13700793154013 0.317168137350543 0.669290253214092 0.274916782635252 1.0 -0.200762534181759 0.519012541492431 -0.573617837864359 0.0391641327073227 -0.774380372046118 0.0159316931008995 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC020559.1 0.255028909252297 0.468164280055514 0.79015557103108 0.569311139552279 0.101053378689636 0.478335084675213 True False False False False False False 0 insufficient_or_context_specific +AL161457.2 0.270697687266644 0.468231855010934 0.79015557103108 0.297075983733743 0.427091280379519 0.747434316946782 True False False False False False False 0 insufficient_or_context_specific +GABBR1 -0.119780315661553 0.468266081593512 0.79015557103108 -0.227759248244763 0.14748199337155 0.532796338690088 0.0655219557870707 0.869246189449544 -0.951277345877247 0.0067921010527433 -0.885755390090176 0.0136347686097924 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CRNKL1 0.238453479399913 0.468478237761127 0.79015557103108 0.0769227585375372 0.816187162371569 0.936230700610385 -0.092251756672778 0.822483954809629 0.196043776938052 0.492553941573279 0.103792020265274 0.759886908670394 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IFT46 0.22228834042606 0.468538961930381 0.79015557103108 -0.0760055970622572 0.810768958252716 0.933438195229734 0.255159830929681 1.0 0.0732760591367184 0.869015643979454 -0.0766432478541185 0.816038869386692 -0.0033671887174001 0.993999298012455 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZSWIM5 -0.255371782258051 0.468683597417796 0.79015557103108 -0.166853592913318 0.635098204164715 0.861847932958146 False False False False False False False 0 insufficient_or_context_specific +NPC1 -0.144676265326057 0.468691785824178 0.79015557103108 -0.11655540303854 0.560646979072899 0.822697818631225 -0.273587799153806 0.390322177355621 -0.0555508209050167 0.857237588702973 -0.329138620058823 0.249077815077982 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HSPA14.1 0.201662264128094 0.468717641379831 0.79015557103108 -0.0501969408728712 0.862823440608413 0.958148375052923 False False False False False False False 0 insufficient_or_context_specific +KLHDC8B -0.295994865591699 0.468719865634368 0.79015557103108 -0.45829439057723 0.252176661558438 0.618991529980024 0.3917496521779371 1.0 0.631543088364032 0.0773897446667143 -0.944614491875972 0.0109594897696129 -0.31307140351194 0.343511849126757 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF644 0.118742947793765 0.468981407260122 0.790470258277836 0.0157059453361835 0.925026914178883 0.978485542437683 True False False False False False False 0 insufficient_or_context_specific +VLDLR-AS1 0.384414575509677 0.469136212663119 0.790514987957659 -0.615069257221564 0.24320758084078 0.609898739043611 False False False False False False False 0 insufficient_or_context_specific +HECTD2 -0.125054972782452 0.469232565782407 0.790514987957659 -0.0098268165943875 0.953172664225123 0.987149466215884 0.533962165296945 0.377310099426656 -0.572464347219772 0.224993678840906 -0.0385021819228271 0.954294637985888 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DLG1 0.132445137812935 0.469505640340718 0.790722691133722 0.222713131141756 0.215578677736505 0.587852789707652 0.309722589263047 1.0 -0.360710497117351 0.162528269234489 -0.148618533269787 0.518002838571767 -0.509329030387138 0.0459994710981761 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRAF6 0.174291635561435 0.469600240075211 0.79074709617074 0.569509116456458 0.0196270532597995 0.330467462546779 0.746557557031255 0.782813728722866 0.0280630888036341 3.0 -0.295538819205898 0.293843453845735 0.0750864842450243 0.768302137310591 -0.220452334960874 0.39061855563964 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EMC2 0.139081092796689 0.469718798787409 0.79074709617074 0.108565449656949 0.575950820506936 0.829928048970172 0.417947895464281 1.0 -0.316090286728725 0.252211611819311 0.467173002032871 0.057094402761589 0.151082715304146 0.55939381413386 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL354733.3 0.262551451968179 0.469765983009163 0.79074709617074 0.290032192288443 0.425460057152022 0.746056682180874 True False False False False False False 0 insufficient_or_context_specific +DAPK1 0.234272238447133 0.469819713419119 0.79074709617074 0.114537346356337 0.723981198442711 0.902378599287888 0.786072085088729 1.0 -0.387259304944622 0.0893287270780726 -0.267131825009068 0.185673805661246 -0.65439112995369 0.0108387751714437 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM120A -0.170542621288501 0.47061804701335 0.791712131989634 -0.246832192935582 0.294414019318441 0.652324662738756 0.408401986346966 1.0 -0.0128335261975678 0.975847144073887 -0.0057902344178054 0.986622064789267 -0.0186237606153732 0.958206167045128 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TAOK3 -0.0948793891682289 0.470767415225223 0.791837242304907 -0.0691725223876192 0.599883952561866 0.843257280459236 0.9284718305235309 1.0 -0.16781136606828 0.496595109419479 -0.289898679795368 0.159982503792165 -0.457710045863648 0.0464766508010504 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ILKAP -0.111879528771009 0.470949282085847 0.791914985505651 -0.182374005003256 0.233455155430969 0.602697571243329 -0.0333403591462513 0.918658847405116 -0.202951229934191 0.354118811240292 -0.236291589080442 0.312098475317367 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP3M1 -0.163344812180128 0.471158765252953 0.791986644937222 -0.0293673405252612 0.903783241254792 0.969631486756234 -0.190341447422825 0.682427626091247 0.191368248737783 0.59843725004979 0.0010268013149578 0.998370018945312 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPRY2 -0.212178190545683 0.471231303608224 0.791986644937222 -0.53832239578015 0.0533515560897782 0.416631456505827 1.01082698884995 1.0 -0.118690608114811 0.823856848480834 -0.0044663457320602 0.992480765724818 -0.123156953846871 0.782240803546941 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZDHHC2 0.212679667202768 0.471449259062935 0.792224388832007 0.634703124771669 0.0353004327063463 0.37720666979567 0.0357915078785397 1.0 True False False False False False False 0 insufficient_or_context_specific +LRRC28 -0.153912600149063 0.47152283192085 0.792224388832007 -0.208700561658781 0.328253458440904 0.677287114006341 -0.323911293778757 0.361567364079523 0.367331872342689 0.213392341444452 0.0434205785639319 0.907103647767016 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCM2 -0.129811978127174 0.471748242296417 0.792362015296892 -0.057382911755825 0.753756524757135 0.913602082065829 0.33026991279391 1.0 0.44969782961362 0.115478656376494 -0.0546930812219558 0.836543207084056 0.395004748391664 0.138303939022004 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INIP 0.223981493801561 0.471754842598623 0.792362015296892 -0.0613279370880534 0.844933995306909 0.951223689862907 0.380852038269783 0.361404241681459 2.0 False False False False False False False 0 insufficient_or_context_specific +GPD1L -0.248730854666407 0.472066531309933 0.792627748131039 -0.190879274911221 0.584963307292773 0.834487582542508 0.4401980122091529 1.0 -0.264770135572102 0.489584344007056 -0.0582566700607883 0.870827370971172 -0.32302680563289 0.334316328011206 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PGLS -0.167408823040838 0.472087279645094 0.792627748131039 -0.280875290279741 0.215564171434528 0.587852789707652 0.120466516729594 0.699499948805938 0.182942011088303 0.443956507827362 0.303408527817897 0.231937134046773 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RDX 0.116395029653092 0.472138275051724 0.792627748131039 0.105580879932976 0.513996516653999 0.798491683514042 -0.326857721039631 0.231452611570479 0.568235698790746 0.029548873185884 0.241377977751115 0.333219561189023 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PPP2R5E 0.103348113614662 0.472305702777609 0.792635953231448 0.213471759540986 0.135784868688444 0.523136620282319 0.764054562628619 1.0 -0.150683530644417 0.589184956781256 0.028200404128436 0.913901333254574 -0.122483126515981 0.622886710923478 partial_or_other True False False False False False False 0 cross_species_direction_conflict +F10 0.247632736541006 0.472341954203039 0.792635953231448 0.227822100969355 0.508978914021097 0.795764752589181 -0.968599823534752 0.0354416150686449 0.834607335510459 0.0468609020875948 -0.133992488024293 0.766579129305445 reversed True False False False False False False 0 cross_species_direction_conflict +EXT2 0.123756791345486 0.472507178489996 0.792635953231448 0.224468139219876 0.200725023688179 0.575734603933236 -0.0638399388939045 0.816545377930446 0.174313962395885 0.378768138613898 0.11047402350198 0.614123094275601 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TARS2 -0.170195540140119 0.472590385601175 0.792635953231448 -0.354517217414548 0.124270565852126 0.506294648147501 0.454456811322117 1.0 0.00125136739656 0.99699280592687 -0.334448840882088 0.139128552767391 -0.333197473485528 0.172061418666875 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMOC1 -0.501834146544027 0.472623616011107 0.792635953231448 -0.599854273242206 0.388781824439196 0.721906173483826 -0.853930055841664 0.0172937043771707 0.478666941223925 0.110052124829686 -0.375263114617738 0.2211616062855 reversed False False False False False False False 0 insufficient_or_context_specific +TRAFD1 0.23759995540722 0.472821730700264 0.792635953231448 0.141716277833784 0.667714816660983 0.875419277100913 -0.249639689042528 0.326527528213087 -0.252801797312522 0.251678675959451 -0.50244148635505 0.0430420948229289 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC00265 -0.16190040772805 0.472881848596862 0.792635953231448 -0.239613742003742 0.281094324526283 0.643133976474597 0.303674280732066 1.0 False False False False False False False 0 insufficient_or_context_specific +SERPINA1 0.266522379343449 0.473039940603943 0.792754871888322 0.39781590074554 0.28323762246931 0.644071250922027 True False False False False False False 0 insufficient_or_context_specific +PCYOX1 0.269100491022278 0.473449307565323 0.793189112864913 0.216341463149592 0.564487288677584 0.823754286312897 -0.0499279875642112 0.917809466489033 -0.0528962964648969 0.888419621083564 -0.102824284029108 0.786621465818044 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC090204.1 -0.32526221098203 0.473628008502535 0.793362607293315 -0.0456353348234999 0.920735791012074 0.976409047961579 False False False False False False False 0 insufficient_or_context_specific +ATN1 0.134696247427281 0.473845794900553 0.793601507385794 -0.0486515317672522 0.796325991613486 0.928812397200087 0.150384187686429 0.666886976849816 -0.0972056771627783 0.737588975080556 0.0531785105236505 0.87403090303973 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C12ORF4 0.133686607296859 0.473961194167397 0.793655167595361 0.254423237411342 0.175291065856182 0.557192294943862 0.0697144376698384 0.0360804105055488 2.0 True False False False False False False 0 insufficient_or_context_specific +ZNF326 0.160464632857268 0.474098147909508 0.793655167595361 -0.0183449145105833 0.935167377768598 0.981623780880792 0.292634808471329 0.313043476417535 0.0374461799216647 3.0 False False False False False False False 0 insufficient_or_context_specific +ZNF324 -0.194705803201923 0.474191348374036 0.793655167595361 -0.186833778927547 0.492759127638042 0.786325382313799 1.469530810557 1.0 False False False False False False False 0 insufficient_or_context_specific +PAPPA 0.311899135109832 0.474234426660974 0.793655167595361 0.320426089096464 0.462677855822306 0.769320698854699 0.767215684061475 0.178710689781291 2.0 True False False False False False False 0 insufficient_or_context_specific +KHDRBS1 -0.116868410243079 0.474253689369117 0.793655167595361 -0.0182205944599017 0.910998623761649 0.972235264295511 0.521528444954176 0.0209259479310231 -0.353141604904952 0.0657913189709161 0.168386840049224 0.398940133569479 reversed False False False False False False False 0 insufficient_or_context_specific +SLC38A4 -0.431424509585705 0.474668936746741 0.793680078545987 -0.482601882770008 0.424842414234788 0.745882731558725 0.46645274875967 1.0 -0.80320081341497 0.0959807146774546 1.17081742915409 0.0166323205445602 0.367616615739118 0.406225149360659 reversed False False False False False False False 0 insufficient_or_context_specific +OPA1 0.102734922727651 0.474768160929155 0.793680078545987 0.206683315219792 0.133674843865634 0.520597197172027 -0.124647397654755 0.706776681862378 0.42353941433594 0.100429239515985 0.298892016681185 0.26552257421949 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LCN12 -0.533464906369583 0.474869277036174 0.793680078545987 -0.561410869518959 0.451739641843804 0.764215212079295 False False False False False False False 0 insufficient_or_context_specific +EEFSEC -0.103392322636981 0.474925162999379 0.793680078545987 -0.0943154417263269 0.513637259257873 0.798491683514042 -0.57979646314409 0.0982306692466134 0.465533705875142 0.123892935764715 -0.114262757268947 0.740027199449383 reversed False False False False False False False 0 insufficient_or_context_specific +ITCH -0.0928132796721981 0.475006343474526 0.793680078545987 -0.0527827095976898 0.684901131527163 0.883169000123458 0.30839011741656 1.0 -0.123994903439629 0.762342010100613 0.379021256807924 0.206042416874614 0.255026353368295 0.428681667052741 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC239800.3 0.20068246780424 0.475343906606307 0.793680078545987 0.1636933140137 0.559480812571658 0.821900433996322 True False False False False False False 0 insufficient_or_context_specific +STK17A 0.231780925718563 0.475425850134319 0.793680078545987 0.222291762782535 0.494447115725189 0.787030400697505 0.809433584392179 0.706917660559695 2.0 True False False False False False False 0 insufficient_or_context_specific +UBE2R2 -0.0893263874527053 0.475453318282543 0.793680078545987 -0.0198057979052971 0.871250332596048 0.958683313195135 0.459216318031778 1.0 -0.137113899215553 0.629072786176249 0.0051018150936202 0.985412074926917 -0.132012084121933 0.594799852358159 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01847 0.330025395477336 0.475533126862369 0.793680078545987 -0.188858089046608 0.68219890778944 0.881775090169539 0.68857321264431 0.344219682078403 2.0 False False False False False False False 0 insufficient_or_context_specific +NGDN 0.222374857394146 0.475543597599489 0.793680078545987 0.211134332183394 0.499405477450354 0.790276233651205 0.286991753048115 1.0 -0.521414931796582 0.186228488985398 -0.060776054839294 0.877595243140742 -0.582190986635876 0.115942613421478 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC2A8 -0.311167465232709 0.475621695108965 0.793680078545987 -0.579938763119361 0.163999406613127 0.544850245278 0.131512281158438 1.0 0.0750499984483278 0.873026380943741 0.102663399790101 0.757706375572795 0.177713398238428 0.624860862242267 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCD4 0.128298381600146 0.475977265628013 0.793913135797364 -0.0382648247743553 0.84289130077356 0.950469545398617 -0.198940070433823 0.612401041125157 -0.0180879166769214 0.959097388016661 -0.217027987110744 0.524642663912922 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NPIPB13 -0.147438454798303 0.476061329828922 0.793913135797364 -0.137387013537814 0.507783571004345 0.794484134953152 False False False False False False False 0 insufficient_or_context_specific +ASXL3 -0.316539432730483 0.476105249206787 0.793913135797364 -0.584970577866598 0.179946723147763 0.562759923872656 1.46727348624954 0.0197806586967602 -0.86509610784198 0.058314242245298 0.602177378407561 0.309311746049473 reversed False False False False False False False 0 insufficient_or_context_specific +SSH1 0.20293131028039 0.476191187152392 0.793913135797364 0.214538890699553 0.450706031660969 0.763947905803589 0.9609252973356078 0.6441923698132089 0.125686531563853 3.0 -0.0856133339457581 0.798645769177701 -0.150925957762443 0.547408982264838 -0.236539291708201 0.362120390132418 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HNF1B 0.452764552650911 0.476212529740927 0.793913135797364 0.499870076320516 0.43655349391748 0.753988514441477 -0.304374531427741 0.696252562003339 0.593475141618754 0.274760047893108 0.289100610191013 0.655316934567585 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CASKIN2 -0.258552995984384 0.476295674603852 0.793918022912413 -0.224843512725409 0.538115339899856 0.812087893451657 0.152513831783925 0.628807273711293 -0.514157750431211 0.0507606994444176 -0.361643918647286 0.179034788798252 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATG16L2 -0.161797766596627 0.476395276343812 0.793918022912413 -0.239193123988802 0.290404782636041 0.649871491113039 0.410847208826793 0.666991223896615 2.0 -0.0918915540949379 0.813913635736174 -0.519219960463056 0.0758372035063263 -0.611111514557994 0.0551076256465999 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CSTF3 -0.143800984354895 0.476498693355828 0.793918022912413 0.13084029983031 0.510982534826829 0.796519013040946 0.454450154953636 0.278518963409668 -0.48048281307307 0.170584897469786 -0.0260326581194343 0.95468228973023 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARL10 -0.165818109389115 0.476516244667168 0.793918022912413 0.0795795475449001 0.745980597696493 0.909686203566594 -0.285629010173857 0.607049719231444 -1.19905938430611 0.0234068557329342 -1.48468839447997 0.0154438315851624 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF333 0.192762128826796 0.477239749114543 0.794747203651631 0.0452881865095159 0.867056136459734 0.958391272020028 True False False False False False False 0 insufficient_or_context_specific +ZDHHC16 -0.165330847668826 0.477436142661222 0.794948871505627 0.0485641729034184 0.83106852701615 0.943790632272401 0.517712172500331 0.0856678972356269 -0.88082162559556 0.0062734727993991 -0.363109453095229 0.203431524418898 reversed False False False False False False False 0 insufficient_or_context_specific +DLG5 -0.181786335467668 0.477676426230657 0.795223542753591 -0.241915162953088 0.345190307910245 0.691144142244059 0.577787739475311 0.0796349841669779 -0.545503277280444 0.0646185894376236 0.0322844621948668 0.928175067898893 reversed False False False False False False False 0 insufficient_or_context_specific +ABL2 -0.0989713953552134 0.477778672434319 0.795268362535321 -0.125650830954777 0.367452526447777 0.708317354196916 0.8021038650454109 1.0 0.512381492423412 0.16518128396071 -0.382420366218354 0.217765878690549 0.129961126205058 0.730124900744758 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TXK 0.42449785477268 0.477903231721497 0.795319193975074 -0.0343203987852046 0.956026823072063 0.987410276805219 False False False False False False False 0 insufficient_or_context_specific +EHMT2 -0.202834348554199 0.478035196530197 0.795319193975074 0.0497788481900038 0.862451073053547 0.957895900410199 0.0791224906682771 0.770271252112411 -0.790638652399611 0.0038069866811309 -0.711516161731334 0.0082417906738905 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRPF40B 0.171419081054405 0.478196127377066 0.795336281166835 0.152188402026124 0.530088620452305 0.807335410549169 0.8571905971519109 0.0453789546970046 2.0 -0.369483727940046 0.335139138234414 -0.779113216902958 0.0337099353769757 -1.148596944843 0.0091603772838437 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PREB 0.208134004629917 0.478507165912767 0.795650994921333 0.169319769764635 0.564926107138548 0.823754286312897 -0.38993442492909 0.142287864398762 -0.214185415267875 0.362589375743519 -0.604119840196965 0.0274062627658919 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ERBB4 0.413549945457612 0.478536069118248 0.795650994921333 0.764323691362111 0.200338104299295 0.575556382365159 True False False False False False False 0 insufficient_or_context_specific +R3HDM4 -0.298261067069335 0.478665265460314 0.795716900193189 -0.104585053900983 0.810418151013317 0.933438195229734 0.0954048728211744 0.757421621264086 0.0880441560004615 0.714805018800508 0.183449028821636 0.455366807437429 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TPR -0.136449555584894 0.478726439669174 0.795716900193189 -0.156104962054843 0.41449704751358 0.736663818217135 0.152934905020681 0.505884763721993 -0.0559351508233728 0.781734878353471 0.0969997541973082 0.647665578851794 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COPS2 0.167924115965558 0.479290174025699 0.796181592963709 0.200046132567354 0.398659780520596 0.728959004281672 -0.0506872469051207 0.908740055132902 0.456930160488282 0.117990542696991 0.406242913583161 0.191822458982586 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TXNRD3NB 0.241677408932358 0.479307653426533 0.796181592963709 0.388102957465454 0.271568467635818 0.635606269407883 True False False False False False False 0 insufficient_or_context_specific +ANKDD1B 0.245149351459286 0.479473930758239 0.796259928777002 0.586146388233082 0.101265901631205 0.478335084675213 True False False False False False False 0 insufficient_or_context_specific +PRMT9 0.141011143822296 0.479637750047829 0.796259928777002 -0.0635109724018364 0.759373520504231 0.915406319729464 0.292708573905298 0.3474545876283 -0.189763330319942 0.455588847139468 0.102945243585356 0.739914349687052 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HAUS6 0.12882862489447 0.47968526184573 0.796259928777002 -0.164666195822682 0.373209001952764 0.711656305116691 1.09560405927427 1.0 0.253116822806825 0.684020812566494 -0.376037888423785 0.403753487958263 -0.12292106561696 0.836646723307243 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCNE1 -0.642572164617481 0.479754895731294 0.796259928777002 -0.975515072565355 0.272234649897486 0.636178272159728 False False False False False False False 0 insufficient_or_context_specific +ACMSD -0.534299201958709 0.479807318325373 0.796259928777002 -0.699704687711375 0.352523452417626 0.696603122306959 -0.295785175047369 0.440619610306709 0.346698377050301 0.252812291924551 0.0509132020029314 0.895708945356197 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPATA5L1 0.203202540128395 0.480172608582642 0.796619563902443 -0.188723557434349 0.4935867619886 0.786363265568912 0.350751252368237 1.0 False False False False False False False 0 insufficient_or_context_specific +COA5 0.22049121202811 0.480271457085394 0.796619563902443 0.31206863046772 0.322668600990308 0.672877524535327 0.8171744804298009 0.0160176215787441 2.0 -0.212136255525512 0.5465958828745 0.20894292525329 0.466593234166156 -0.0031933302722218 0.993714358504368 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NIPSNAP2 0.14391637607702 0.480340465591927 0.796619563902443 0.0562525783041785 0.783293233211632 0.924938995064714 -0.344161341484141 0.42557524288983 0.108469781451657 0.779472762368971 -0.235691560032483 0.551979607096428 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SEM1 0.20303428401312 0.480401284653045 0.796619563902443 0.291246608116609 0.31124475952999 0.66386306487225 -0.0597836531520991 0.883287950806448 -0.566108398474711 0.0583263592689521 -0.62589205162681 0.0481964535889002 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MYO7A -0.323321944835211 0.480584988945154 0.796659000421368 -0.993575287493153 0.0205736349937672 0.333389311130767 0.370618716457462 0.283680773601636 -0.567397595376218 0.0695574388626545 -0.196778878918757 0.54959516694183 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRTO4 -0.25846605876836 0.480686966691669 0.796659000421368 -0.190838539436177 0.605960465095284 0.846820726734085 False False False False False False False 0 insufficient_or_context_specific +CUL7 -0.2399666235562 0.480726888774819 0.796659000421368 -0.352067255218405 0.294016673415511 0.652324662738756 0.876553009716077 0.0386023924114195 -1.04980113927688 0.0104715078501896 -0.173248129560808 0.687406299245416 reversed False False False False False False False 0 insufficient_or_context_specific +SBF2-AS1 0.239775235421264 0.480803955836246 0.796661670702932 0.48149917533786 0.169132624626774 0.548771435405495 True False False False False False False 0 insufficient_or_context_specific +UBTD2 -0.127397121235819 0.481119338811941 0.796934104044003 0.0886525768572322 0.610940976807921 0.848390744855719 -0.221892778638928 0.690404920343846 -0.480507323986674 0.259754807187465 -0.702400102625601 0.144918247267443 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASXL2 -0.12586334722503 0.481223455864432 0.796981528943792 0.111572036240436 0.515788419379925 0.799542807959285 0.552019520473519 0.570365525010976 2.0 -0.141416598130913 0.63835245579401 -0.282642321386916 0.235003003026468 -0.424058919517829 0.100569090799552 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NBPF12 -0.194992456110082 0.48156692863797 0.797249465986022 -0.268542250765948 0.333875387760981 0.683680439096284 False False False False False False False 0 insufficient_or_context_specific +METTL3 0.150521996697886 0.481679092357469 0.797249465986022 0.189505330035326 0.37321850364 0.711656305116691 -0.162990236045513 0.636051679018572 -0.199739118709432 0.461040480506244 -0.362729354754945 0.211136094499554 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ST5 -0.216572051944094 0.481922985799714 0.797306555827919 -0.366866803692509 0.234086214452249 0.603018788225434 0.559153025499156 1.0 -0.066120275771821 0.861071562331872 -0.182887206546077 0.495493510734479 -0.249007482317898 0.373813820722143 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF76 0.117359505140883 0.481944900265041 0.797306555827919 0.0746282899215021 0.657335369323987 0.871691185476023 0.314123228960666 1.0 True False False False False False False 0 insufficient_or_context_specific +ERAP1 -0.173841774053498 0.481948327267833 0.797306555827919 -0.173926724382633 0.481547875245584 0.780620676622582 -0.479748445092417 0.0755837218040978 0.710549768210759 0.0094583642610821 0.230801323118342 0.340033350930498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF462 0.191249900661671 0.482135340993706 0.797490980763207 0.113919030836495 0.674871863026829 0.878580824298291 2.98852980285023 1.0 True False False False False False False 0 insufficient_or_context_specific +C1ORF43 0.118415515073136 0.482651042440876 0.798049838774213 0.174188139533754 0.297200109372606 0.654889895570548 True False False False False False False 0 insufficient_or_context_specific +MBOAT2 -0.212274648779686 0.482761137504159 0.798049838774213 -0.0940989491243911 0.754471409503074 0.913618862571469 1.44501587263621 0.194647842171679 -0.692237535054515 0.359487082261972 0.752778337581693 0.512377477402176 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NR2C1 0.127157970915678 0.482775556000275 0.798049838774213 0.198077977305407 0.272000447037346 0.635912471173671 0.0447569699800175 1.0 -0.232835423918411 0.544977091899077 0.255061964924212 0.39638924329604 0.0222265410058013 0.95394833255486 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PPP1R9A -0.367555478698149 0.482922877797418 0.798126560581373 0.225014793301679 0.682553770152946 0.882056634672559 0.237477596956173 0.616569134632343 -0.0635977411004198 0.876078778899699 0.173879855855753 0.685617081722594 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFIB -0.179271507560606 0.483018379480257 0.798126560581373 -0.102431062638292 0.687328227088219 0.884451344908836 0.251307136373327 1.0 -0.262484865218811 0.344242605448043 0.0753401279429411 0.770761492256319 -0.18714473727587 0.460965884124289 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC112229.3 0.298370698324993 0.48304875185783 0.798126560581373 0.374343395318735 0.383941420447246 0.719298323474503 True False False False False False False 0 insufficient_or_context_specific +TNFSF14 -0.487929232182606 0.483212881464667 0.79821158050632 -0.348949997016597 0.61987517136824 0.854057426504748 False False False False False False False 0 insufficient_or_context_specific +CLPB -0.188126019442733 0.483251413392347 0.79821158050632 -0.194625924763353 0.467984820493359 0.772583012794147 0.258515877441404 1.0 -0.263665199712464 0.408060424334973 0.568586518930747 0.0408427016445781 0.304921319218283 0.272337985157702 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WARS -0.17240245345463 0.483650465017467 0.798732729101864 -0.0754433406353535 0.756995147651031 0.914454644719928 -0.27327994602798 0.286412943521853 0.417604333222834 0.0629598231908977 0.144324387194854 0.545429013479587 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRGAP3 0.299572873245703 0.483841475538651 0.798811305510099 0.0435183445095235 0.917320455718546 0.975930957742715 True False False False False False False 0 insufficient_or_context_specific +LRPAP1 -0.195018235761585 0.484268873771859 0.799338576064485 0.0208161976036121 0.939770344954674 0.983658266508924 0.348266850854523 1.0 -0.18219149112029 0.548600138356448 0.529957051119342 0.0442007116312022 0.347765559999052 0.181098480623044 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DEK 0.120596967200361 0.484368486728998 0.799338576064485 0.0669299601939232 0.698471360243319 0.889371148052465 -0.0022153413843243 0.994302327353405 0.0176428605837921 0.940025122441445 0.0154275191994678 0.950559787025098 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CRCP -0.157966128972074 0.484449771048362 0.799338576064485 -0.205628556605324 0.361919901737481 0.703533322359016 -0.271241660311416 0.494237256331264 0.173393080858203 0.597455102459263 -0.097848579453212 0.79800462110695 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ORAOV1 -0.200900916361286 0.484463681401462 0.799338576064485 -0.417771539002773 0.141326395540894 0.526923646040233 False False False False False False False 0 insufficient_or_context_specific +TTLL7 -0.202073804057071 0.484604998222303 0.799446808004856 0.0867709871939597 0.76636718067317 0.919276700304713 0.0941402890312358 1.0 0.187744778553642 0.830205324617202 -0.291790265246391 0.613858789365658 -0.104045486692749 0.895466334963513 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RP9 0.194721896748214 0.48472098012664 0.79951321796236 0.0608111230514477 0.821720076933318 0.938727610069463 0.3740317642760561 1.0 -0.274558511853337 0.313073086199875 0.172386451090648 0.463530534137655 -0.102172060762689 0.701386934013348 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PANK3 0.164359608341422 0.485180219616773 0.799932494758413 -0.006625940369998 0.977219705755347 0.993403201748984 -0.252790838582133 0.320349903765884 0.474989213993227 0.0389870773095688 0.222198375411094 0.329389366070926 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OARD1 0.186745332926274 0.485219990313355 0.799932494758413 0.183405598961256 0.493212130767758 0.786363265568912 0.0223036894322961 1.0 -0.437678806964011 0.0838710750888851 0.481770846687034 0.039110718478162 0.0440920397230225 0.868138033765485 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPS6 0.227795384887693 0.485278237253991 0.799932494758413 0.577357513355986 0.0668182564230855 0.436862290339161 True False False False False False False 0 insufficient_or_context_specific +ACVR2A 0.22627158085611 0.485498800874916 0.80017114262213 0.378057272711296 0.24139999153113 0.608572375975566 1.53277678955634 1.0 -0.666274450695224 0.092307296143151 0.63778385367213 0.0736734941147535 -0.0284905970230936 0.945470333114829 reversed True False False False False False False 0 cross_species_direction_conflict +ZC3H7B -0.141687074982447 0.486061229937886 0.800848075169195 -0.255532451526339 0.21066649919723 0.582866063554599 0.17213316309131 0.533322688599393 -0.143326960626156 0.526075373720194 0.0288062024651538 0.918284999159875 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CACHD1 0.299766769568172 0.486545512751438 0.801395869521011 0.329373334083054 0.444565785266095 0.759994423711047 0.464060740771869 1.0 -0.226554782725269 0.43278340701235 -0.280679215570825 0.248233468778482 -0.507233998296094 0.0604551190265147 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LAMA4 0.260388470100853 0.486668004564613 0.801466448904668 0.316464306229082 0.395605119419135 0.726526152518217 0.4045749348407729 0.268859511608694 2.0 -0.599751874816719 0.213530011101045 0.422134793398084 0.299718864327055 -0.177617081418635 0.705527564044774 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DIP2B -0.106765483930742 0.486799916321 0.801466448904668 -0.0785318946618682 0.607741039508127 0.847290359847723 0.0434060005175048 1.0 0.220505958734782 0.503388661270573 -0.310274396978159 0.234088290580622 -0.0897684382433771 0.780716193674029 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IMPG2 -0.340998683371989 0.486917931608223 0.801466448904668 0.0336246599956595 0.947332448021207 0.986094250821001 1.28397106945341 0.186378151687577 -0.895784771225815 0.198844343739126 0.388186298227593 0.720897925961752 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPAG9 -0.113187444352064 0.486933039012809 0.801466448904668 -0.165584503329466 0.30060746972155 0.658632920234719 1.11088160785866 0.00359298063186586 2.0 0.149058648713063 0.569955095817952 -0.410288374049756 0.0651813483869062 -0.261229725336692 0.242439782132289 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBKBP1 0.247830545505873 0.486967917192977 0.801466448904668 0.337289586057687 0.351146329862176 0.695703312194568 0.0278469323342682 1.0 -0.62982725449508 0.121161692262138 -0.439152404186059 0.223445666190522 -1.06897965868114 0.016331056018705 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COG5 0.136751770236494 0.487101220060303 0.801560891738883 0.337489364473851 0.0732749591674344 0.451181493860383 -0.0820267447446571 0.813721649956029 -0.0721038491872337 0.787912172201962 -0.154130593931891 0.57585981979015 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TTR -0.459591685965109 0.487377863639829 0.801867916676465 0.0092713154061936 0.98907556366416 0.996797349534273 -0.270424945008156 0.760122763333641 0.875693358154624 0.19735172752457 0.605268413146467 0.38964349287774 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MOCOS -0.388617083061056 0.487687341593758 0.801870463516161 -0.410325285386451 0.463366250958224 0.769320698854699 -0.880565901343265 0.0067105600844156 0.682706494490518 0.0167392620328519 -0.197859406852747 0.45002220408002 reversed False False False False False False False 0 insufficient_or_context_specific +IPPK -0.144252090150086 0.487833921314116 0.801870463516161 0.0304272482676748 0.886989056786717 0.963622568156774 0.508183450574083 0.3815597626094671 2.0 -0.348526725824894 0.3955403941374 -0.538964023991037 0.129230952096955 -0.887490749815931 0.0333007259026199 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIM55 -0.524543868144184 0.488068820024028 0.801870463516161 -0.627398210956445 0.403559146302366 0.732218158903657 False False False False False False False 0 insufficient_or_context_specific +SEC61A1 -0.1551827636328 0.488246604805766 0.801870463516161 -0.0615979475918511 0.786527875860687 0.926121604088118 0.278586934574174 0.511370640042748 2.0 -0.223336188197045 0.54197599541736 0.664851610558084 0.0363773896667891 0.441515422361039 0.157716168742079 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPINK1 -0.485667437393891 0.488258865712952 0.801870463516161 -0.495018752331147 0.481890702827825 0.780666906162311 False False False False False False False 0 insufficient_or_context_specific +TRAPPC4 0.204465444588875 0.488269773303114 0.801870463516161 0.354403891192055 0.235518671079919 0.604719389411913 0.534130542861798 1.0 -0.0191985199163665 0.963257176400296 -0.0049189521712 0.988665629929683 -0.0241174720875665 0.944785617279326 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC25A3 -0.159909407337405 0.488404664422923 0.801870463516161 -0.201856003277541 0.380464281111258 0.716671165026344 0.161296993201417 0.774247773369274 0.42238111282443 0.313152376086006 0.583678106025846 0.186666319221972 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP1AR 0.141875247753384 0.488413381991902 0.801870463516161 0.306271890321854 0.120512227739732 0.501524675000431 -0.217764326362113 0.372585722743146 -0.141584144384934 0.50054401526696 -0.359348470747046 0.109058041340083 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EXOSC10 -0.101199551502999 0.48842858030616 0.801870463516161 0.125809676714359 0.422361640293861 0.744083797467477 0.0417225957519464 0.928099978041629 0.281156209055045 0.344456963921471 0.322878804806992 0.315446148899377 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TUBE1 0.190772553837565 0.4888064412949 0.802241319320931 -0.148948246311545 0.581701186479736 0.83332444054994 0.363336730985127 0.756740533625439 -1.14737104230293 0.183626825111009 -0.784034311317804 0.46388706973071 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC036108.1 -0.248232482532118 0.489340655345752 0.802993260668394 -0.0358273397647017 0.920398420365832 0.976247390217245 False False False False False False False 0 insufficient_or_context_specific +GUF1 -0.133458801721094 0.489441881036778 0.803034557884428 -0.171594661283248 0.37130699020022 0.710191884517015 0.27987760513105 0.453098367577187 -0.416219428930158 0.173139292329903 -0.136341823799108 0.705629335796316 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RASSF1 -0.187095210655324 0.489664707812678 0.80315053364708 -0.271074523999318 0.31196283204092 0.664337047357073 0.609529984461264 1.0 0.340636539866994 0.267157791103042 -0.936340237650526 0.0054451042448924 -0.595703697783532 0.0518605159057112 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALDH18A1 -0.235346044840897 0.490248842925479 0.803858873055941 0.162560710604666 0.635325216849268 0.861847932958146 0.610659146778616 0.0933305604830216 -1.0375529963023 0.0066531087124478 -0.426893849523681 0.230043308631942 reversed False False False False False False False 0 insufficient_or_context_specific +VPS4A -0.217443046362407 0.490328332895559 0.80386436936511 -0.364292304079154 0.227945836336827 0.600160304082166 0.247939601510559 0.407578212261387 2.0 0.209227399326441 0.538431550837553 -0.156423801356825 0.567977633923453 0.0528035979696157 0.877506382329822 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RALA 0.174636911668006 0.490448676166739 0.803936830145696 0.157950120260292 0.532543242115622 0.809588416163677 0.584344252694577 1.0 -0.133736789189723 0.674273152012007 0.228404276745029 0.336540573888303 0.094667487555306 0.735876830609472 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MICA 0.223230003739816 0.490626692882187 0.803961853503271 0.0767809736961229 0.809570128907204 0.93302493406858 0.343638452127965 1.0 True False False False False False False 0 insufficient_or_context_specific +CIR1 0.128957917997789 0.490692383403588 0.803961853503271 -0.0396267515291792 0.827037139026542 0.942259214105446 -0.120316096815533 0.770405194413138 0.0851933214512808 0.790505349091612 -0.0351227753642525 0.927074750236329 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FECH 0.238263666149065 0.490851619139977 0.803988750653662 0.483120739731676 0.16158827135201 0.543541307772207 -0.627433099410114 0.0323990390241975 0.894049695209798 0.0050414149221111 0.266616595799684 0.301479648742887 reversed True False False False False False False 0 cross_species_direction_conflict +PCED1A -0.238592111893254 0.490899072411802 0.803988750653662 -0.254472811811379 0.462984862662479 0.769320698854699 0.398589439584914 0.32188935048107 -1.25251420670312 0.0052452603737904 -0.853924767118204 0.0391192924005971 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLR2D -0.264768948668119 0.490982053281887 0.803988750653662 -0.0373758247466782 0.92972584631316 0.979967786975403 0.0142743074176662 1.0 -0.035993396855147 0.947172925971506 -0.0781465280819924 0.834985123413266 -0.114139924937139 0.787599022017731 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRP19 -0.188947385053202 0.491013398770109 0.803988750653662 0.237680418084464 0.39311122755722 0.725225989961407 -0.0166616376197954 0.967664160496778 -0.109451773732314 0.709152901316051 -0.126113411352109 0.694312956614556 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LGMN -0.239102053489878 0.491092245049523 0.803993165333053 -0.235978393548432 0.497235795791027 0.789146979692815 0.568970853041994 0.0668812580296161 -0.137743333420717 0.609575524619445 0.431227519621276 0.13369550466671 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MARCH5 -0.131609585840678 0.491812593356866 0.804885147950109 -0.32150208751147 0.0931362006359913 0.472709733823144 0.412845065573549 0.291426170894083 -0.557689726531684 0.100149256514641 -0.144844660958134 0.712637516855692 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERLIN2 -0.228161739575697 0.491929191980415 0.804885147950109 -0.116204446348097 0.728266219774002 0.903847977944507 -0.0265401598853866 0.940023552473003 0.0056489043238541 0.983989591500095 -0.0208912555615324 0.942660682843177 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HELQ -0.153086678687331 0.491967920901975 0.804885147950109 -0.135291985247416 0.544618814660217 0.815113627216777 0.0609077809911212 0.893706359585748 -0.301517065985319 0.320372735248689 -0.240609284994198 0.480705412567541 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MFN1 0.0963177566109825 0.492051266021956 0.804885147950109 0.0931004683614409 0.505512340828262 0.792927764365643 -0.304815102156925 0.26375158794362 0.25083717892486 0.287539538073065 -0.0539779232320651 0.848856992637175 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HINT3 0.375639263861694 0.492094490435495 0.804885147950109 0.180439653150336 0.741293103258248 0.908482017899081 0.273187914424667 1.0 -0.438098701607441 0.127252575967881 0.637727661881308 0.0208454180722105 0.199628960273867 0.447349684612844 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRKACA -0.170351006603688 0.492225778300754 0.804975180808451 -0.250889826633669 0.304704394440726 0.661341495477036 0.325830736861558 1.0 0.0305068870442977 0.925059466657728 0.0970272182807445 0.670049273231752 0.127534105325042 0.595332156027235 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB10 -0.106126467341789 0.49255307465778 0.805139275383261 0.0689860776156825 0.653738359393532 0.870639750062571 -0.296148805342531 0.243613040855743 0.316851575724907 0.151371973761088 0.0207027703823759 0.939798992054325 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMIM13 0.194994830591076 0.493354306600842 0.806071613910815 0.41112425371652 0.147050928707417 0.532796338690088 -0.0628533124581116 0.897356985172915 0.386120820517793 0.211421354651901 0.323267508059682 0.347378977593184 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLMAP 0.118630060084885 0.493473553072756 0.806141694776754 0.149649630395373 0.384584110249439 0.719298323474503 -0.365525161980962 0.172127296730473 0.117320404140391 0.630911129925371 -0.248204757840571 0.313609576142196 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FHIT 0.115416568491801 0.493848527552574 0.806255258064028 0.150381455688927 0.366543754714363 0.707896919588155 0.266583246644355 1.0 -0.609542001883565 0.569268769155167 0.262357406619479 0.763276683201078 -0.347184595264085 0.717149944566396 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PUS1 -0.213414817527248 0.49426581025963 0.80636503439555 -0.131975670595835 0.672430193645032 0.877133430257505 0.44786676346327 0.182183491245202 -0.220901028127492 0.432087242159328 0.226965735335778 0.474614818802221 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIM52 0.145552821165422 0.494331288630101 0.80636503439555 -0.0875604676067169 0.668728391522143 0.875941737812246 False False False False False False False 0 insufficient_or_context_specific +SLC9A9 0.161383019230582 0.494351710781825 0.80636503439555 0.168679279095431 0.474436481819256 0.776724885585255 0.9668965811753629 1.0 -0.406729374860809 0.244079276398375 0.0886003742426471 0.78496531005561 -0.318129000618162 0.319022065274302 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CHCHD6 -0.189004708599495 0.494427654098202 0.80636503439555 -0.202448458489536 0.464073627517898 0.769834633203601 -0.0704248039778325 0.923269418503395 -0.0989845054232127 0.84813369095186 -0.169409309401045 0.769914276490153 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TEX22 0.218092629571182 0.494456362150416 0.80636503439555 0.28597552104654 0.372931950681604 0.711495398499526 True False False False False False False 0 insufficient_or_context_specific +GPR89B 0.189828317133609 0.494463091307105 0.80636503439555 0.183135172237516 0.509876532788877 0.796465794993973 0.0213434431885789 1.0 True False False False False False False 0 insufficient_or_context_specific +MAP4 -0.102625499571065 0.494501793124579 0.80636503439555 0.0802658954980473 0.610052882138445 0.848354258489409 0.405144818023438 0.321216964821541 2.0 0.05269665116239 0.895696465239926 0.16041453062134 0.563888731148189 0.21311118178373 0.469546742012676 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPCS2 0.187110833437978 0.494595740522562 0.80636503439555 0.283401899474683 0.297237391511088 0.654889895570548 True False False False False False False 0 insufficient_or_context_specific +METTL24 0.204017259905059 0.494895723477266 0.806494881831017 0.195376752301267 0.513829627562327 0.798491683514042 -0.268229864993642 0.828908674361171 -0.459052886425647 0.604925864039319 -0.727282751419289 0.463373871319516 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MYPOP -0.163317023245073 0.494943620865248 0.806494881831017 -0.36504402766615 0.122242977230783 0.5038394341269 -0.163037705574072 0.651785166596844 -0.295071012599288 0.290875026512471 -0.45810871817336 0.135142113331727 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAJB6 0.136072857694624 0.494988334368724 0.806494881831017 -0.067719290824198 0.738732896332496 0.907558041400239 0.521259445199972 1.0 -0.0492635416404861 0.892901495028562 0.0712274813180379 0.790095963285207 0.0219639396775518 0.942902737313631 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AQP4-AS1 -0.401203856629572 0.495175118126654 0.80666217706352 -0.557735366483916 0.334475043840713 0.684300634473422 False False False False False False False 0 insufficient_or_context_specific +CDC5L -0.123493694445265 0.495320221055389 0.80666217706352 -0.159610651866045 0.374009911163072 0.712264906576428 0.490965699432435 1.0 0.196843029840865 0.561151114197066 -0.213042734837912 0.420122371101311 -0.0161997049970467 0.963244255335912 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP15 -0.0926037680525569 0.495630649969707 0.806935558733936 0.0043494237210756 0.97521277357436 0.992701163073476 0.0722263792262043 1.0 -0.0077741979160148 0.983221385589207 -0.093122138746331 0.724140797136045 -0.100896336662346 0.72794300482408 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIMK1 -0.192865686510385 0.495715919228323 0.806935558733936 -0.0418081193438874 0.885730489600169 0.963282087886134 0.328719632076158 1.0 0.135038313922047 0.784039873542692 -0.294948345339712 0.409376764059604 -0.159910031417665 0.704019087595202 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GNAL -0.223312990933155 0.495739541566517 0.806935558733936 -0.135097143776736 0.68182385275668 0.881652937832826 0.8549100211340909 1.0 False False False False False False False 0 insufficient_or_context_specific +OSBPL6 -0.33005769942431 0.495793802756871 0.806935558733936 -0.262938036819422 0.588134775456305 0.835590841220889 False False False False False False False 0 insufficient_or_context_specific +ZNF93 0.382435677568163 0.495997340992535 0.807018019139957 -0.143011563801071 0.80842028573621 0.932859303825974 False False False False False False False 0 insufficient_or_context_specific +ZNF618 0.118328481611206 0.49645226837937 0.807390814844898 0.258606823380175 0.126923298247341 0.508560221212687 True False False False False False False 0 insufficient_or_context_specific +NBPF9 -0.220695071940128 0.496576261068482 0.80743851711031 -0.318957611127911 0.322516959996715 0.672877524535327 False False False False False False False 0 insufficient_or_context_specific +CBL -0.162605843050275 0.496790178647487 0.80750220010519 0.0629053331963169 0.79620935166456 0.928812397200087 0.266792985348862 0.460530280699928 0.0548298102644447 0.867591304581815 0.321622795613306 0.310129378501062 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTF1 0.126566101380855 0.496830298530338 0.80750220010519 0.101043913496628 0.587577470390918 0.835274227991216 -0.032591619132458 0.93266482312261 -0.39656035868759 0.125019365070392 -0.429151977820048 0.124430269353667 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EXD2 0.136681716576057 0.49698256867721 0.80762535941111 -0.100946879504067 0.594538441834217 0.840087910718103 0.309347596817597 1.0 -0.119687254748526 0.718861660614878 -0.100290235379829 0.705881187105021 -0.219977490128354 0.41880410378184 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF425 -0.321608700872588 0.497264801436688 0.807959645055178 -0.84413395779931 0.0666136374053993 0.436862290339161 False False False False False False False 0 insufficient_or_context_specific +KDM4C 0.0972917965628082 0.497588196628046 0.808333538495104 0.110903139275763 0.436529825697617 0.753988514441477 0.0878495836397329 0.0665482366212791 2.0 -0.204987769372844 0.488138552825059 -0.0752985617688806 0.771326341926412 -0.280286331141725 0.277592067862735 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SMAD6 -0.24242974324988 0.497648039422066 0.808333538495104 0.0993293365972271 0.79781040764803 0.92925379048471 0.514906069586305 0.882906723925498 2.0 0.53196229932653 0.207672815509816 -0.418676009074682 0.237497393592395 0.113286290251848 0.797349700931942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CSMD2 0.287161329756904 0.497892615960157 0.808519738417984 0.324517143308978 0.444553244682227 0.759994423711047 True False False False False False False 0 insufficient_or_context_specific +TTLL4 -0.247133990556652 0.498202050712521 0.808519738417984 0.273811238017442 0.437062009099468 0.754357618759665 0.203904600139513 0.473730582282561 -0.108909739010939 0.644290629201867 0.0949948611285734 0.727281137768212 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF1B 0.285629770324125 0.498341779727511 0.808519738417984 0.172523433675798 0.678752699253219 0.880269131398536 0.0254142790329123 1.0 -0.480882947749531 0.111643741533259 0.818523420650967 0.0080396336631288 0.337640472901436 0.210483182770729 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FH -0.197435662522556 0.498358747910676 0.808519738417984 0.035801445872534 0.906005287842289 0.970714826340858 False False False False False False False 0 insufficient_or_context_specific +GSTO1 0.190175581513571 0.498485138815987 0.808519738417984 0.182547666792187 0.51557716306281 0.799350732708873 -0.495839983179888 0.388908784812314 1.03209080375098 0.0459841804230629 0.536250820571089 0.28948953379064 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FBXO34 0.114880937159448 0.498496878483398 0.808519738417984 -0.227668526947264 0.196559336412627 0.571879675616801 -0.190342396571369 0.62696363173285 0.0276760635824344 0.937951091658225 -0.162666332988935 0.639541814565957 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB8A -0.163760386760024 0.498528461555321 0.808519738417984 -0.214608106240366 0.374699744873256 0.712838905321506 0.257563228912453 1.0 -0.262960196100958 0.340572934556339 0.360224624365406 0.130998981317865 0.0972644282644486 0.717627569281498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNM1L 0.122342394423251 0.498815631516201 0.8088612252416 0.161228975242828 0.368180113642042 0.708317354196916 -0.036031360000352 0.901995164796902 -0.400650909408452 0.0577080394056011 -0.436682269408804 0.0518777867306521 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SNX7 -0.172588659089717 0.499036249794757 0.809019813362094 0.304667212427439 0.273183301166604 0.637071187742661 0.414726292202709 0.253635576603694 -0.578435414604377 0.0698418093279623 -0.163709122401669 0.652803870796479 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF496 -0.123991963710633 0.499105420552052 0.809019813362094 0.0893546527104142 0.62104168994947 0.85421549797896 0.960290422412517 1.0 False False False False False False False 0 insufficient_or_context_specific +WISP1 0.333768235024702 0.499224429244689 0.809019813362094 0.429898931411568 0.384576605635313 0.719298323474503 0.0514803086709988 0.0553138621111874 2.0 True False False False False False False 0 insufficient_or_context_specific +ZNF571 0.244775470140512 0.499473294843912 0.809057847033143 0.264195808884463 0.468007724451979 0.772583012794147 True False False False False False False 0 insufficient_or_context_specific +NRG1 0.286523036679743 0.49956594892621 0.80908379947276 0.159472609499508 0.706694915071181 0.892997076377691 0.322081205682562 1.0 True False False False False False False 0 insufficient_or_context_specific +TOPORS 0.15829436880851 0.499715339124484 0.809187062594484 -0.0639410110483673 0.792814337834619 0.927620871373898 0.0837008944686031 0.813721649956029 -0.12628287387676 0.625244426542908 -0.0425819794081564 0.893412772228668 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RANBP17 0.242288377512824 0.50005821885973 0.809187062594484 0.423773907759959 0.227024517321396 0.599153964290576 0.0373384508048177 1.0 True False False False False False False 0 insufficient_or_context_specific +UNG -0.24470980941153 0.500082492799117 0.809187062594484 -0.147122632499479 0.688177991110213 0.884776330996302 -0.557886415675376 0.301132840267642 -0.804598146193577 0.107640497622777 -1.36248456186895 0.0223675591038225 partial_or_other False False False False False False False 0 insufficient_or_context_specific +METTL7A 0.29055151910258 0.500137594370789 0.809187062594484 -0.0348709621278428 0.934176944423355 0.981340479683686 0.298072217791512 0.696795353569348 0.0164229532323335 3.0 False False False False False False False 0 insufficient_or_context_specific +CRELD2 -0.297119143454019 0.500144025513505 0.809187062594484 -0.445323885850065 0.303969674470794 0.661341495477036 0.198061390409547 1.0 -1.29453587670749 0.029005255238903 0.510716058584146 0.305779102981132 -0.783819818123343 0.135275628399412 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPHN -0.190641464499526 0.500242845004186 0.809187062594484 -0.338280418674256 0.226480176052583 0.598909102217928 0.190215773271325 0.167923299591914 2.0 -0.410993219043009 0.149029449922273 0.460021239213636 0.0699884985143911 0.0490280201706269 0.870298642859208 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL357055.3 0.274234124547162 0.500603187659635 0.809582804330161 0.257582620931051 0.527172808027498 0.804819865166353 True False False False False False False 0 insufficient_or_context_specific +LCA5 -0.18869896641716 0.500788824813748 0.809582804330161 -0.0058507576264174 0.983525296327494 0.99451887511202 0.240757719504172 0.703423411961727 -0.307758252434622 0.50613225386717 -0.0670005329304507 0.915362925925265 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC092802.1 0.244885728762529 0.500864405740371 0.809582804330161 0.0127307506663145 0.972096465930408 0.992040338141303 True False False False False False False 0 insufficient_or_context_specific +ZBTB37 -0.175308069115588 0.500879055454498 0.809582804330161 0.0942813819684796 0.724042552050752 0.902378599287888 0.34697785792499 0.198592985494894 -0.279970995065607 0.220023018357499 0.0670068628593829 0.812201448650283 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TNFAIP2 -0.218858322459416 0.500947571575009 0.809582804330161 -0.107544591538199 0.739852094271014 0.908274440555399 -0.807369259813904 0.267118378459995 -1.22246539636765 0.0786270911010679 -2.02983465618155 0.0152555001528633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUP98 -0.107816812843924 0.501125864959921 0.809623088331575 -0.210190795707553 0.185598795015709 0.56775396895769 -0.073429211459314 0.829010029691934 -0.385792487076384 0.113632538432953 -0.459221698535698 0.08409627547008 partial_or_other False False False False False False False 0 insufficient_or_context_specific +YARS2 -0.160565448935998 0.501382724145852 0.809630582793574 0.184581335155908 0.474789075566365 0.777061395106136 0.361811260762407 0.256852070279905 -0.0670274142973284 0.81416268495829 0.294783846465079 0.314695333934021 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIG1 -0.283280543728822 0.501486166149368 0.809630582793574 -0.176742828938361 0.680146679487814 0.881048329971919 1.31424844727551 1.0 1.60470853952927 0.0088756776480007 -1.65624822433748 0.0039880084537205 -0.0515396848082092 0.940561151768772 reversed False False False False False False False 0 insufficient_or_context_specific +C5AR1 -0.223868298872049 0.501539201769612 0.809630582793574 -0.350415105847953 0.289563291050241 0.649046020716462 0.0197914830867833 1.0 False False False False False False False 0 insufficient_or_context_specific +CPEB2 0.138617227055989 0.501560617738731 0.809630582793574 0.397933700295116 0.0423800470443477 0.3908928278867 -0.797118085265585 0.0348864160558608 0.311883727082799 0.327802365867553 -0.485234358182786 0.149147174241594 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRAF7 -0.264971900926595 0.501562176538852 0.809630582793574 -0.339092155975225 0.387312441566826 0.720952884002564 0.202304580175442 1.0 0.225136380577943 0.396911871643237 -0.129958746505441 0.565809395582846 0.0951776340725016 0.712637516855692 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALS2CR12 0.194463216692752 0.501831043215194 0.809630582793574 0.380796616092638 0.204265242506456 0.577301933200215 True False False False False False False 0 insufficient_or_context_specific +LINC01006 -0.257016008818835 0.501842863223322 0.809630582793574 -0.33561432676291 0.375053998774481 0.712838905321506 False False False False False False False 0 insufficient_or_context_specific +NAB2 -0.362607966119104 0.50190504386874 0.809630582793574 0.0203569127052352 0.969851697156487 0.991737938845345 0.179196957743976 1.0 -0.0167568316686245 0.971220331487005 -0.869299247844785 0.0195002842283603 -0.886056079513409 0.0247189928973452 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC019257.8 -0.216026592076106 0.501974028695467 0.809630582793574 -0.159791867422913 0.627176162187207 0.857403330360291 False False False False False False False 0 insufficient_or_context_specific +REPS2 -0.221618467500987 0.502152295547064 0.809757292206281 -0.201449757614138 0.544352956970127 0.815113627216777 -0.330726965649306 0.505374658311079 0.343785313838652 0.375339775970537 0.0130583481893452 0.980570491852017 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF227 0.195128416899344 0.502205981186468 0.809757292206281 0.210961012235574 0.469212685272859 0.773450043889281 0.594780638971308 1.0 True False False False False False False 0 insufficient_or_context_specific +LAMB2 -0.203692759474701 0.502425900922725 0.809854400916103 -0.0398011177194471 0.897836749728349 0.967796120806635 0.7366198300603509 1.0 0.365906650569069 0.164367830295177 -0.597375882735583 0.0207984171306111 -0.231469232166513 0.34527793139878 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC096677.1 -0.284795336091812 0.502523783939492 0.809854400916103 -0.411739034239324 0.327929577369102 0.677020038690453 False False False False False False False 0 insufficient_or_context_specific +ZNF32 0.184536532241458 0.502573028490463 0.809854400916103 0.0453989298035067 0.866074829721407 0.958391272020028 0.361449274408376 1.0 True False False False False False False 0 insufficient_or_context_specific +FBXO44 0.241439240545621 0.50280461379816 0.809980334525629 0.328612065524615 0.369431801275432 0.709345639075664 -0.472206958563311 0.33919882164384 -0.896239018441636 0.0561402164288765 -1.36844597700495 0.0150451173382639 partial_or_other True False False False False False False 0 cross_species_direction_conflict +OXA1L -0.145434358082987 0.503233969959841 0.810219684557214 -0.216831361178612 0.310864582252061 0.66386306487225 -0.302025165181916 0.287739609987688 0.634961710588677 0.0197535595606055 0.33293654540676 0.193730781338835 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLU 0.254981946199825 0.503301237765384 0.810219684557214 0.310294472803003 0.41605362830024 0.737601948039338 0.7679543578225921 1.0 -0.833807022734634 0.0664611863411628 0.368289961075528 0.35456686088229 -0.465517061659106 0.259453367563996 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IRS1 -0.178296488031393 0.503336892499599 0.810219684557214 -0.333058014283838 0.210657240645659 0.582866063554599 0.621549507658448 1.0 -0.237628814429524 0.567755911976946 -0.0056907402731732 0.988937394284849 -0.243319554702697 0.501915483923286 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCNK15-AS1 0.315914558979056 0.503801408299269 0.810255529903501 0.867760902888622 0.0899884921550024 0.471142565909827 True False False False False False False 0 insufficient_or_context_specific +WASL 0.143697028348202 0.503855180333898 0.810255529903501 0.323751333722689 0.125691610591657 0.507996233320616 0.0835919589144415 1.0 -0.106237657346699 0.746002328976631 0.102749765813296 0.692887896743352 -0.0034878915334033 0.991496902871955 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MACROD2 -0.241749696462083 0.50389999364692 0.810255529903501 -0.179701087985514 0.618562100078873 0.853546133343446 0.9019416603471279 1.0 -0.549008642751765 0.191050117746697 -0.340293041048028 0.358834047540053 -0.889301683799793 0.0378906119744685 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCMF1 -0.107392912238418 0.504130284240378 0.810255529903501 -0.056059124374522 0.730042808842499 0.904213522802984 0.954015265442046 1.0 0.157598388751165 0.550622074043692 0.0133751773430412 0.956271496699276 0.170973566094207 0.45454968020336 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BRD4 -0.0987352144567434 0.504382115628357 0.810255529903501 -0.13596787185898 0.354457905992951 0.698014991474228 0.4226750811363421 1.0 -0.128346102987611 0.665565367447906 0.226503450250052 0.329594387373366 0.0981573472624414 0.709907780430773 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYO15B -0.143979587148253 0.504465980614391 0.810255529903501 -0.309885451364213 0.14112112480201 0.526686115859676 0.731909610279168 1.0 2.51684954293386 0.0062318125041279 -1.51351722288195 0.015208253927927 1.00333232005191 0.259778332685418 reversed False False False False False False False 0 insufficient_or_context_specific +GRM7 -0.327139878425628 0.504478375961508 0.810255529903501 0.0919850172905646 0.849601233650677 0.953127856970211 False False False False False False False 0 insufficient_or_context_specific +OXSR1 0.145042824089036 0.50450373360996 0.810255529903501 0.436796294670421 0.0411050281523999 0.388181473374811 0.0570827087202689 1.0 -0.0095202423639906 0.976901931488306 -0.0686882167764305 0.766965637918028 -0.0782084591404211 0.76162395891842 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HSPB11 -0.125433782208726 0.504522519996441 0.810255529903501 0.18303688572827 0.345812077382565 0.691144142244059 0.269692975467136 1.0 -0.311001334370765 0.642436051472277 0.470521671251562 0.333195402261728 0.159520336880797 0.790054144334233 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AARS2 0.223756210360998 0.504670329330846 0.810255529903501 -0.155351865081267 0.648361829011195 0.86855377695836 False False False False False False False 0 insufficient_or_context_specific +COL7A1 -0.417362622292955 0.504933921678073 0.810357628651906 -0.139237545644483 0.835889761066277 0.946895140530977 1.03717483929816 1.0 1.69639335856904 0.016064147920668 -1.87389020196371 0.005080044663964 -0.177496843394664 0.82869638988022 reversed False False False False False False False 0 insufficient_or_context_specific +NAIP -0.136954946944144 0.505015012262082 0.810357628651906 -0.21384788834092 0.28445717708933 0.645315615751859 False False False False False False False 0 insufficient_or_context_specific +TAF2 -0.0869912506883336 0.505040446130769 0.810357628651906 -0.112437936784911 0.379116959751305 0.716305809064831 0.405538939694451 1.0 0.0356729072319548 0.925059466657728 -0.24474332988874 0.328053204509839 -0.209070422656785 0.445295730777742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XPC -0.133258353450381 0.505461410800138 0.810643737483082 -0.297600464483684 0.117151930654081 0.496743005560555 -0.511975920320121 0.0637421436670442 0.766564117139381 0.0078158456251695 0.25458819681926 0.303069189232965 reversed False False False False False False False 0 insufficient_or_context_specific +ZSCAN29 -0.214047567569525 0.505595179815179 0.810643737483082 -0.329037225280816 0.3014144381283 0.65914118429134 0.238724432567317 0.516834074449481 -0.579747352458878 0.0622729642642479 -0.341022919891561 0.294951286541724 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LPCAT2 0.238012346011607 0.505931334692664 0.810934117456376 0.286363018446784 0.426619663466833 0.747171397205924 0.320469492165371 1.0 True False False False False False False 0 insufficient_or_context_specific +SFMBT1 -0.205392088588037 0.506135763842008 0.811109202142798 0.118823398142881 0.70963901605485 0.894500642532718 0.99962243685859 1.0 -0.0088344096183534 0.983539512738157 -0.078253295930537 0.798563262768891 -0.0870877055488904 0.798833221094232 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF430 -0.172262114050378 0.506194216037024 0.811109202142798 -0.233326667306694 0.365593820696789 0.707078138654827 False False False False False False False 0 insufficient_or_context_specific +TIMM21 -0.260542839750597 0.506338382490462 0.81121709291871 -0.158181897535833 0.690824723167086 0.88580609997548 -0.111974210734457 0.794017374586637 0.220445909065964 0.462952698040639 0.108471698331506 0.765133275132717 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC12A8 -0.308214968476376 0.506649441158232 0.811592292481962 -0.0061705440445151 0.99274413414222 0.998236115892821 False False False False False False False 0 insufficient_or_context_specific +KCTD13 -0.146208389199949 0.506781532045155 0.811680736549264 -0.170808679917334 0.439014250408685 0.756012470366155 1.10692945300835 1.0 0.432662072832463 0.402481427307569 -0.644498418690907 0.124121860259538 -0.211836345858444 0.683152973380346 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC068888.1 0.17429397972806 0.507218307933932 0.8122570749532 0.232138720665237 0.38679748921476 0.720477739899883 0.0411712468428328 1.0 True False False False False False False 0 insufficient_or_context_specific +CRP -0.376838638622838 0.507687444071486 0.812885052245489 -0.0357387391091889 0.950254688065527 0.986917609553614 -1.81605326711504 0.0012265530655824 1.5227931647309 0.0033468313127418 -0.293260102384133 0.457963780128296 reversed False False False False False False False 0 insufficient_or_context_specific +NSD3 0.0914443847183248 0.507922917214719 0.813138765724489 0.180026356558841 0.183560744927734 0.565541146173142 -0.111203076483519 0.6987232884367 0.0399352379824147 0.876837486235366 -0.0712678385011043 0.785075526772521 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZC3H12C -0.159335471891913 0.508507324039616 0.813827546947137 0.118282585172632 0.630255140608691 0.859165109689678 -0.337426164100522 0.442217568831759 0.25581734365101 0.467505524032438 -0.0816088204495118 0.851187176049742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC013652.1 0.242278025084201 0.508924472684874 0.814239302342493 0.28909130967234 0.433266693792543 0.751350456611089 True False False False False False False 0 insufficient_or_context_specific +NPL 0.276095473412606 0.509073085315666 0.814239302342493 -0.132416105890682 0.743449666271071 0.909330581150367 0.815638880275013 0.29734866333484 -0.413828710566848 0.467664495217247 0.401810169708165 0.605707145479832 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF2 -0.155239738546876 0.509179669484687 0.814286420845096 0.151209656437103 0.526744076444017 0.804819865166353 0.132057523267875 0.709633509313965 -0.151372776072772 0.575493748592571 -0.0193152528048975 0.954813048846082 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CIITA -0.364966399625824 0.509372965908127 0.814427787992266 -0.317856531079122 0.566617590766659 0.824128464432343 2.29559857894024 0.0426771445279066 -0.577024719222687 0.380917555535181 1.71857385971755 0.123513408654961 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF189 0.198427844047568 0.509440138360554 0.814427787992266 0.145380282198404 0.627931937784574 0.857992157257607 0.007209036419689491 1.0 True False False False False False False 0 insufficient_or_context_specific +GTF2H1 0.129704407109319 0.509499482827137 0.814427787992266 -0.0163621418794316 0.932221002344792 0.981045440677165 -0.31432193870477 0.337847548130968 -0.0409386447354875 0.900217493371686 -0.355260583440257 0.232041226350144 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STK32C -0.259631795186076 0.509653229602805 0.814453277622935 -0.52744904290307 0.145465503630763 0.532658823056677 0.390725133403479 1.0 0.543980409463016 0.380451518694565 -0.705615712823548 0.149726297872621 -0.161635303360532 0.807847238569808 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IRF2 0.196447963196309 0.509669710670082 0.814453277622935 0.169116917506696 0.572116258718138 0.827679290154302 0.452445442473152 1.0 -0.340499181048322 0.26845219967212 0.352493411064893 0.185710708865736 0.0119942300165713 0.971858040486316 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MIA2 -0.146148669479627 0.509919496395418 0.814571693601863 -0.135828590559339 0.540093752408642 0.812783927483158 -0.553454603650933 0.121398919615447 0.756093532023782 0.0282577609182254 0.202638928372849 0.548851241821563 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARAF -0.216161861839298 0.510052421519409 0.814571693601863 -0.297701222725558 0.361112908045608 0.703177809506737 0.334801986065216 0.330249851042281 2.0 -0.0513301123652807 0.873536099921662 -0.375647554898087 0.103025106484495 -0.426977667263367 0.0835563993808325 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WARS2 0.156787114298444 0.51017867123758 0.814586416220053 0.278450251873963 0.234395932233336 0.603303815826319 1.61605920058695 1.0 -0.212487210448604 0.702189004792812 -0.532789106372459 0.212039753034813 -0.745276316821064 0.122104384902603 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GPR89A 0.1675555352784 0.510264407620877 0.814586416220053 0.0954635467253043 0.705833269947859 0.892947759038953 True False False False False False False 0 insufficient_or_context_specific +SMAD9 -0.237716743657417 0.510432924196338 0.814586416220053 -0.0572897463572996 0.875463758988427 0.960395245514428 0.4300998268117089 1.0 -0.0507004961028715 0.945771141117588 0.654437593961376 0.139019427650116 0.603737097858505 0.225752101414604 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYBU 0.199088732278441 0.510447407625675 0.814586416220053 0.0163921261394075 0.955749021773658 0.987410276805219 0.792698280345428 0.7233078413069219 2.0 True False False False False False False 0 insufficient_or_context_specific +GATA6-AS1 0.155567129643837 0.510685737716974 0.814720462196405 0.324559377180918 0.167010862007332 0.547438895086435 0.51079981863811 0.3362090720313811 2.0 True False False False False False False 0 insufficient_or_context_specific +CCDC43 -0.203240222682666 0.51108034738862 0.815083892607991 -0.249489944871525 0.410669104372203 0.735240191860684 0.0243551597616718 0.95762493377024 -0.128554531168309 0.691887378013697 -0.104199371406638 0.778389943524509 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM126B 0.19496245005247 0.511366794877274 0.815083892607991 -0.0269377430693659 0.925514357064426 0.978485542437683 -0.0099933656583517 0.982442777647471 0.188653132423671 0.520401649587229 0.178659766765319 0.595356573835764 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FIS1 -0.168070396754454 0.511413431470818 0.815083892607991 -0.284022372796847 0.240845891554987 0.608162815336196 -0.128665696268083 0.697717684190826 0.440165377981867 0.0940870464662318 0.311499681713785 0.248405364806512 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALG2 -0.22085179666202 0.511444058719977 0.815083892607991 0.146213295479942 0.67175828644433 0.877088599168621 0.178342328024359 0.735809641856386 -0.157284015399449 0.698130202390368 0.0210583126249101 0.967567973182642 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE2J1 0.149775338611712 0.511484558057674 0.815083892607991 -0.104613796178208 0.640377330092652 0.864640237429136 -0.0195646992554281 0.954939919877077 0.156381884224122 0.487752217051725 0.136817184968694 0.59106747847098 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB30 -0.190808030725778 0.511552350146217 0.815083892607991 0.128830270273298 0.654685532885077 0.871208703831691 -0.122995423491474 0.844356614344803 -0.18579552807838 0.676210884661815 -0.308790951569854 0.522717672700246 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MGST2 -0.180202105144699 0.511625640402919 0.815083892607991 -0.195048716309862 0.478041526522851 0.778545319644225 0.327081422071553 0.73588038996484 2.0 False False False False False False False 0 insufficient_or_context_specific +RPS6KC1 0.120146457522936 0.511747980515224 0.815083892607991 0.329545739608501 0.0657043199699777 0.435533238803682 True False False False False False False 0 insufficient_or_context_specific +SPIN3 -0.130956104833046 0.511749900561737 0.815083892607991 -0.225706097868666 0.256706136635412 0.62162921802676 False False False False False False False 0 insufficient_or_context_specific +TESK1 -0.196953134208441 0.512031245595813 0.815116748951848 -0.0982146760920639 0.747336726931143 0.909830759894547 0.296397653192122 0.301052327787728 2.0 -0.266702042232831 0.376978380519378 -0.361887365957855 0.165268306807123 -0.628589408190686 0.034843570054577 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP4V2 -0.175820501402441 0.512092195093541 0.815116748951848 -0.522442634489965 0.0366495311485442 0.377876708853838 False False False False False False False 0 insufficient_or_context_specific +AC108062.1 0.147847151432332 0.512221117002848 0.815118862872336 0.285029388905637 0.215191141172063 0.587852789707652 0.0558771703223587 1.0 True False False False False False False 0 insufficient_or_context_specific +PPP1R18 -0.227335318729545 0.51286881143171 0.815507202676114 0.364567439710815 0.287064332809841 0.647335588595963 0.539424975060707 0.177837786790215 -0.759683360736846 0.0403841792886706 -0.220258385676138 0.57585981979015 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUDT6 0.207741937482643 0.512904558871961 0.815507202676114 -0.0258695694169355 0.9323253774504 0.981045440677165 0.415443063828178 1.0 0.054298596961591 0.911240264788933 -0.0375126699686408 0.918663486618687 0.0167859269929503 0.968382984814672 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PSMD4 -0.122613948700276 0.513557070291805 0.815653704873327 0.259859128203431 0.185594017433421 0.56775396895769 0.0459519046203748 1.0 -0.157718404451363 0.553941800194394 0.44029119737298 0.0515085319770978 0.282572792921617 0.211771133543528 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RACK1 0.155759040409701 0.513585473773338 0.815653704873327 0.119489439318805 0.616165267237345 0.851916120639411 -0.125296115720702 0.752825844669071 0.18101660814408 0.553427222587489 0.0557204924233777 0.879358541868143 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AGAP4 0.148245911133812 0.513588352907546 0.815653704873327 0.178235433005144 0.42969035667166 0.74852333689201 True False False False False False False 0 insufficient_or_context_specific +PALB2 -0.150061230256365 0.514212419237785 0.816293915248071 -0.369800251109508 0.103946663133552 0.480082620019266 1.50837327140747 0.0683464835535966 -1.79303665539651 0.0155807619073965 -0.284663383989043 0.785502173972538 reversed False False False False False False False 0 insufficient_or_context_specific +C6ORF106 -0.108251328458281 0.514223416396564 0.816293915248071 -0.0287047975709953 0.864053095712326 0.958391272020028 False False False False False False False 0 insufficient_or_context_specific +ZNF783 0.152652607341601 0.514601676658578 0.816597126414335 0.0954734206957346 0.68600208666376 0.883592781626934 True False False False False False False 0 insufficient_or_context_specific +CNOT3 0.171773937054037 0.514646455688671 0.816597126414335 0.0884049443235949 0.739359229110428 0.907903552099081 0.228398286724717 1.0 -0.127235749565191 0.693004648496795 -0.230979012984556 0.357686884024074 -0.358214762549747 0.179456041844568 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SHF 0.240942046605796 0.514801256305432 0.816720009627761 -0.132623189721977 0.704901891979467 0.892368606177364 0.300741477541392 0.7270284154203049 2.0 0.0109765883387196 0.978092598315436 -0.488698609848454 0.0738306569115781 -0.477722021509735 0.104924987969908 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIK3IP1-AS1 0.188050688574693 0.515032431535459 0.816776302671649 0.254924771211936 0.381983121025472 0.718125771636418 True False False False False False False 0 insufficient_or_context_specific +DICER1-AS1 -0.278061646429545 0.515141856404371 0.816776302671649 -0.590845395048657 0.148262677314719 0.533523294849626 False False False False False False False 0 insufficient_or_context_specific +EIF3I -0.203731353491607 0.515194733502491 0.816776302671649 -0.119291733455195 0.706345476722261 0.892997076377691 0.0364767251037387 0.95762493377024 0.663801671347617 0.133203320948199 0.700278396451355 0.149370172413192 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CP -0.248721939402858 0.515320657025716 0.816807611000978 -0.0176492770286083 0.963071429714399 0.989935386867005 0.389320103264094 0.3144267874783739 2.0 -0.363192228139625 0.244079276398375 0.605894843079657 0.0403841792886706 0.242702614940033 0.397961815207923 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01344 -0.58002445101833 0.515812609118741 0.817003138786741 -0.821530411574903 0.349705308601305 0.694412008315325 0.9467452421284209 0.882015991497768 2.0 False False False False False False False 0 insufficient_or_context_specific +SERP2 -0.232647474609178 0.515816688340337 0.817003138786741 -0.357170796642466 0.316994890941698 0.669290253214092 0.426207001944855 0.631660427069099 2.0 False False False False False False False 0 insufficient_or_context_specific +VPS37C 0.135771990430334 0.515927515364225 0.817003138786741 -0.0104345482572745 0.961159335558339 0.989172459774339 0.0404351178943871 1.0 -0.47139546909344 0.126250920758554 -0.63812214517399 0.0335484455130118 -1.10951761426743 0.0045467305605998 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TIPARP 0.329464346142602 0.515929997227568 0.817003138786741 -0.163783565989179 0.742631098170975 0.909193347184915 1.66522101397305 1.0 0.0238208677948337 0.962835650365801 0.136103041843891 0.699019007276118 0.159923909638725 0.682847153251179 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NME3 0.206410484823916 0.515937096867006 0.817003138786741 0.414066679248392 0.181593481614001 0.564332404732057 0.447473405803104 0.0464352227709103 2.0 True False False False False False False 0 insufficient_or_context_specific +POLN 0.175963663320665 0.516027481236159 0.817003138786741 -0.0040295562996438 0.988598814756175 0.996718493722613 False False False False False False False 0 insufficient_or_context_specific +MARS -0.12442016898897 0.516198655676456 0.817003138786741 -0.12503076830318 0.513710409453004 0.798491683514042 0.25334840318261 1.0 -0.264705799812425 0.438755593880855 0.192323180667123 0.504073306480859 -0.0723826191453019 0.831541595581064 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ENDOV -0.165881753976721 0.516302935381074 0.817003138786741 -0.393968689255754 0.130912978623318 0.516702515254203 -0.0842389421079745 0.843696053451533 -0.554906853111355 0.0729066936551299 -0.63914579521933 0.0612430771660088 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EXOSC6 -0.183698966397879 0.516400579234525 0.817003138786741 0.0243673276393824 0.933115102415992 0.981085441734921 False False False False False False False 0 insufficient_or_context_specific +SIN3A 0.106795264682803 0.516449985628217 0.817003138786741 0.110063027560907 0.503026469309494 0.79229878349175 0.3766605721021289 1.0 -0.265414419971429 0.351322511055469 0.298617258056089 0.212496910390368 0.0332028380846598 0.912491421579475 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RBMS3-AS3 0.176589975682994 0.516545214074662 0.81703136632214 0.15354028590416 0.573103619616293 0.828086494581747 0.6936564211159649 1.0 True False False False False False False 0 insufficient_or_context_specific +EVA1A -0.352748500770403 0.516868231995384 0.817419831247343 -0.70363772763676 0.180605601393783 0.563538010872213 -1.59036408688501 0.0004848013895938 0.927436404540024 0.0088109125189793 -0.662927682344983 0.0398222967945456 reversed False False False False False False False 0 insufficient_or_context_specific +RABEP1 -0.0885105581146845 0.517282511019209 0.817881138905828 -0.132715768537116 0.33143721242686 0.680349234702553 -0.262652257570079 0.274973819582601 -0.114320507281627 0.59670219735418 -0.376972764851706 0.0952862081287919 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGEF11 0.131255643933356 0.517366087603525 0.817881138905828 0.177345540880711 0.379689537856097 0.716424065042321 -0.311806757537288 0.48819689511927 0.0721478855482914 0.861628794546181 -0.239658871988996 0.554097025513333 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WAPL -0.0885844637670935 0.517403740286183 0.817881138905828 0.0906202649038219 0.519595688399646 0.801093936641861 0.110604892023932 0.741676260980949 0.213621233252127 0.393570679316803 0.32422612527606 0.224078614748809 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KPNA5 -0.128643513931838 0.517572744077945 0.817881138905828 0.0259931549402357 0.897995766568671 0.967796120806635 False False False False False False False 0 insufficient_or_context_specific +ACAD10 0.11435659415712 0.517683002180933 0.817881138905828 -0.0002623905706579 0.998899613988182 0.999467600880139 0.188735753196148 0.688936764998849 0.309060744546892 0.358236365300357 0.497796497743039 0.191486883233161 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARGLU1 -0.148454064372767 0.517826311809397 0.817881138905828 -0.367144568421035 0.0893718939198409 0.470746198832535 0.7083096370355358 1.0 -0.284561612195369 0.46104734065596 -1.03276252376246 0.0091920347644963 -1.31732413595783 0.0045163244044198 partial_or_other False False False False False False False 0 insufficient_or_context_specific +L2HGDH -0.174408108398508 0.517924904985381 0.817881138905828 -0.304050923829757 0.240616403538749 0.607903323417592 -0.0765303698138862 0.862981521576469 0.345542752094557 0.250628437332839 0.269012382280671 0.409509530854742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CES2 0.130244612390728 0.518004351084961 0.817881138905828 0.0164540013413002 0.93421605998302 0.981340479683686 0.339658913507473 1.0 True False False False False False False 0 insufficient_or_context_specific +CRYZ 0.164324735477243 0.518115316239044 0.817881138905828 -0.0191916117323211 0.940075056222616 0.983775641153571 -0.632234267551258 0.164367830295177 1.27891650335982 0.0067728415155337 0.646682235808557 0.112942912147643 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNNM3 -0.221012555240864 0.518217488951576 0.817881138905828 -0.168407032423006 0.625236284828904 0.856338486330344 0.263951615428714 1.0 -0.366774092428856 0.285812233050116 0.0435225399080047 0.900171868249892 -0.323251552520851 0.30129053146099 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL157392.5 0.131262430992342 0.518404215953007 0.817881138905828 -0.0812538684169967 0.670835792431023 0.87672504479995 False False False False False False False 0 insufficient_or_context_specific +TTC19 0.112584881192608 0.518479348766577 0.817881138905828 0.140604103039823 0.420813408554346 0.742471251256147 -0.0688378355663558 0.81990957202397 -0.677027727645019 0.009776171573976 -0.745865563211375 0.0095170977344524 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SMARCC2 0.139596678121938 0.518551020630514 0.817881138905828 -0.0017943090127522 0.993294365517326 0.998495849864984 0.3994257396872801 1.0 -0.0465682138643943 0.885570273582468 -0.116005426133686 0.618103334808114 -0.162573639998081 0.500531468104669 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TAB3 0.111506171628179 0.518627898943915 0.817881138905828 0.0022439803846502 0.989755789915914 0.996896452948454 -0.294107558363209 0.514313773971728 -0.158291994801551 0.674209864373547 -0.452399553164761 0.251241166471911 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NDUFB2 0.210212713020487 0.518671121860121 0.817881138905828 0.200893333897388 0.538530401067122 0.812290593659906 -0.427316593949919 0.486950434535032 1.05359210555976 0.0394463580733521 0.626275511609838 0.21948582251453 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BTD -0.212422085017537 0.518792806050213 0.817881138905828 -0.332688197666586 0.306585703256038 0.661696690217148 -0.501190753768743 0.191952816629053 0.614903025845043 0.0695507254345332 0.1137122720763 0.766433561582778 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC021752.1 0.181991886717862 0.518815410920929 0.817881138905828 0.35560525870733 0.212387303892456 0.585096123643677 True False False False False False False 0 insufficient_or_context_specific +AC005480.1 0.205202737228668 0.518864166356435 0.817881138905828 0.42143892925389 0.19013295335016 0.569886897607216 True False False False False False False 0 insufficient_or_context_specific +ADGRE2 0.375196559906866 0.518957778150162 0.817906586312795 0.0126729872478203 0.977790043640969 0.993500350721674 True False False False False False False 0 insufficient_or_context_specific +AP002884.3 0.141434991772417 0.519078341620809 0.817950761366036 0.486687558889424 0.0285012609146883 0.367419185271403 True False False False False False False 0 insufficient_or_context_specific +LMNA -0.282887395381874 0.519341455706717 0.817987166775364 -0.715720741257653 0.114732385953515 0.492613299848511 0.239681845755186 0.711914205706798 2.0 0.478253281499926 0.127449546753644 -0.494156771731205 0.0813035439706629 -0.0159034902312794 0.963592920213227 partial_or_other False False False False False False False 0 insufficient_or_context_specific +E2F5 0.254414707885336 0.519360855802377 0.817987166775364 0.482207558220101 0.228819637785344 0.600424738880655 -0.368259176698848 0.457696546809139 -0.0211251405743422 0.964162706928666 -0.389384317273191 0.374409165101061 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DLG4 -0.14992591932173 0.519397046374294 0.817987166775364 -0.30287013814019 0.183435146624048 0.565541146173142 0.683703956188048 0.137495008606554 -1.13325164994074 0.014781317215436 -0.449547693752695 0.301223495224207 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A30 0.208848095023355 0.519840901255846 0.81833062090439 -0.0376200376815913 0.908485480390165 0.971429112904874 -0.416344502568207 0.562154734828276 0.549169488588485 0.336974565227119 0.132824986020278 0.846494600271507 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VANGL1 -0.242226007950227 0.519959203789304 0.81833062090439 -0.195788058284371 0.604275883911531 0.845706111908648 1.03134251993215 1.0 0.323128050636623 0.324652062590133 -0.245199495574067 0.357402198448824 0.0779285550625555 0.818801381285969 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MMS19 -0.123393716633358 0.52004856584825 0.81833062090439 -0.154443099162849 0.416460494268266 0.7378737872939 0.271185940380319 1.0 -0.325896657332972 0.371422156197039 -0.331910590277465 0.283977037318444 -0.657807247610437 0.0604551190265147 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PFKP 0.261594288521999 0.520153452625625 0.81833062090439 -0.0411214407339278 0.920278768522717 0.976218550995966 0.398154748011349 1.0 0.349115664425141 0.291992895520755 -0.0966381929736342 0.74726909698651 0.252477471451507 0.406626709410067 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP6R3 0.116405609378213 0.52015692336516 0.81833062090439 0.190537823754398 0.284825860097728 0.645735759268157 0.338192528574663 0.251477111890121 2.0 -0.043261833432972 0.900364871566824 -0.12508245348269 0.604925864039319 -0.168344286915662 0.507979726353779 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF813 -0.192417398229538 0.52034122933712 0.818344810459857 0.0253309966084355 0.932222233122379 0.981045440677165 0.265306858065959 1.0 False False False False False False False 0 insufficient_or_context_specific +FMO5 -0.292590321687406 0.520669091984734 0.818556548210427 -0.6325261502122 0.163216004993134 0.544298760692042 0.236674713152299 0.695727847094886 0.365192395463359 0.444504571381064 0.601867108615658 0.225752101414604 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF70 -0.228276122259771 0.520688177475017 0.818556548210427 -0.313826364670356 0.369337755447882 0.709345639075664 False False False False False False False 0 insufficient_or_context_specific +ZNF260 0.196311795515994 0.52093811819127 0.818676247682855 0.381835102551064 0.220859587315522 0.5925760086083 0.260245326501283 1.0 True False False False False False False 0 insufficient_or_context_specific +LINC01146 -0.400272654104273 0.520976327526565 0.818676247682855 -0.420261126447177 0.500717602561102 0.790819493321426 False False False False False False False 0 insufficient_or_context_specific +SACM1L -0.118947512882165 0.52099694148334 0.818676247682855 0.120308660133745 0.509742922825093 0.796465794993973 0.322133434114028 1.0 -0.0152136571240036 0.960850127566663 0.27855769709869 0.182081283578643 0.263344039974686 0.235518715572105 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NR5A2 -0.333554374895588 0.521106355855493 0.818726325167008 -0.579103707587308 0.263609636051379 0.626379950271573 -0.635233977718428 0.0916405363048768 0.366307513545386 0.256613815226716 -0.268926464173042 0.434024575676335 reversed False False False False False False False 0 insufficient_or_context_specific +TSC1 0.127421283670931 0.521251626384931 0.818832714086015 -0.0339105920417499 0.864378372642994 0.958391272020028 0.469336070567807 1.0 -0.276326234139807 0.404863621737126 -0.224126735393377 0.423099042444661 -0.500452969533184 0.101269687162694 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LARP4B 0.0960278697329932 0.521531268968477 0.818997316179198 0.0726672791556243 0.626146572352711 0.856624485564009 -0.32964656762863 0.193010785431213 0.237471536329581 0.281591533323744 -0.0921750312990489 0.714871734867846 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AATF 0.122697854870869 0.521805506600123 0.818997316179198 0.196056465966815 0.308661348371814 0.662330926800867 0.5851249807422281 1.0 -0.18920773504357 0.617946177395842 -0.227707822741725 0.446009958153473 -0.416915557785295 0.194889912265034 partial_or_other True False False False False False False 0 cross_species_direction_conflict +POLM -0.17601404807038 0.521916768647998 0.818997316179198 -0.117814187331309 0.671697951498379 0.877088599168621 0.5669648913845671 0.433248015839606 0.0394707239962472 3.0 -0.0990148556165668 0.850850415323871 -0.43283539686367 0.233417676516236 -0.531850252480237 0.18260724997507 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BTG1 0.213399009039451 0.521919102430635 0.818997316179198 -0.117548047796441 0.729666851825312 0.904204533048315 -0.17420686668224 0.714168325030578 0.44436122282027 0.206342513763361 0.27015435613803 0.484997022470032 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARSJ -0.163554417261052 0.521942402733312 0.818997316179198 -0.128626457471479 0.61346948951496 0.850400399282578 False False False False False False False 0 insufficient_or_context_specific +SLC31A2 0.4346882856102 0.521965669022413 0.818997316179198 -0.244479828602511 0.703386159659019 0.891727211991511 -0.0937688194051366 0.885896209712577 0.328565801691373 0.443490355856049 0.234796982286236 0.63611047288112 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARAP1 -0.156053911505933 0.521976978648402 0.818997316179198 -0.181378644926995 0.45759510872147 0.76776776876263 0.3596141076795921 0.546734973362925 2.0 0.0297386160261658 0.932963913852509 -0.579843325403045 0.0273407528137498 -0.550104709376879 0.0409507325430519 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTTP -0.253616999700607 0.522137232321111 0.819127028060369 -0.327752448043872 0.40443812128874 0.732758892415649 False False False False False False False 0 insufficient_or_context_specific +SNIP1 0.18752504612918 0.522290844069617 0.819246283120936 -0.197265156358454 0.472727858984655 0.775593712997022 -0.231600307989352 0.546281332495745 -0.564237215805607 0.0820142590455269 -0.795837523794959 0.0325664229433652 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTF2I 0.0713301214741683 0.522369133561596 0.81924737257031 0.109224883157456 0.322691487753055 0.672877524535327 -0.0557713870711998 0.853490782058691 0.197808748665993 0.35012310749604 0.142037361594793 0.536551554718554 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PSME1 0.215982793511456 0.522486105329172 0.819309119273043 -0.0204256485720853 0.951023054399617 0.986917609553614 -0.21865002392512 0.386966283877942 0.0949016529722666 0.67436119281336 -0.123748370952853 0.600988911671378 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MPV17 -0.15672018971515 0.522644740585071 0.819436170344101 0.0004662874910943 0.996688554845756 0.998795540446485 0.0869403187027715 0.772894003001544 0.236606488210481 0.279411316174752 0.323546806913253 0.171513141985865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OPTN 0.120764892147559 0.52276979941765 0.819510548218493 0.126736781460717 0.501915770104935 0.791401837032243 -0.556552264607524 0.0446430522046363 0.158272243825193 0.510486874086292 -0.398280020782331 0.114775545812327 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SREK1IP1 0.117275848290052 0.52303705310112 0.819673213569207 0.170863855271195 0.34692114156148 0.691856064986949 -0.0111918533728039 0.976032050018046 -0.0454445961775729 0.870665364364913 -0.0566364495503768 0.851693343152573 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC25A29 0.185999953773107 0.523080632180572 0.819673213569207 -0.204724413929408 0.483395536807009 0.780666906162311 0.407563439741159 1.0 False False False False False False False 0 insufficient_or_context_specific +MOGS 0.155139972709509 0.523136749515068 0.819673213569207 0.238463587601237 0.320394711261138 0.672472248121257 -0.351993926840482 0.382879533187396 -0.1204802920065 0.742606262023619 -0.472474218846982 0.194093119192605 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NDUFS3 0.222056773359815 0.523230642052358 0.819673213569207 -0.0996929243374946 0.778802944298094 0.922929913000972 -0.0095653585081946 0.982553593752984 0.454773610171656 0.129993032768194 0.445208251663461 0.158348615321108 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC144NL-AS1 0.248977331789797 0.523289221308959 0.819673213569207 0.201442322165513 0.608361745635161 0.847936692532885 True False False False False False False 0 insufficient_or_context_specific +GOLGA8N -0.192740884724346 0.523339376081647 0.819673213569207 -0.0233239392886556 0.939685574237767 0.983658266508924 False False False False False False False 0 insufficient_or_context_specific +CPSF3 -0.127530918376252 0.523627188387912 0.819874802684524 -0.0686594447799001 0.732874037116386 0.904431845923655 0.130857345046198 0.738154569148248 0.123961590850394 0.677585067137296 0.254818935896592 0.417328850343201 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZC3H15 0.0978143169219319 0.523652226921392 0.819874802684524 0.0432151674511641 0.771580961580795 0.920641521976153 -0.0381894570925182 0.901995164796902 0.169315509473228 0.413982425917678 0.13112605238071 0.571086683557291 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC007344.1 -0.504708030292744 0.523804852686937 0.819874802684524 -0.442155578277395 0.577860380597052 0.83075298180061 False False False False False False False 0 insufficient_or_context_specific +TESK2 -0.183321940965033 0.523932595459959 0.819874802684524 -0.0424808264647969 0.882983301676883 0.962778177759102 -0.597715678997466 0.181375533959097 0.320413079435315 0.39561140610665 -0.277302599562151 0.501416914035667 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC005697.1 -0.356204456488404 0.524098985758939 0.819874802684524 -0.388532196172871 0.486915743806652 0.782147598778917 False False False False False False False 0 insufficient_or_context_specific +CHD2 -0.0743748699462153 0.524461022108043 0.819874802684524 0.018778416795139 0.87165892227587 0.958683313195135 0.862535194554658 1.0 -0.0834974900675828 0.850634666014012 -0.41189377501969 0.190002666945131 -0.495391265087272 0.136768796932199 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPN2 -0.094913045343467 0.524528184495589 0.819874802684524 0.0777377306307683 0.595041028627409 0.840573077367967 -0.330957639952879 0.253195178850292 -0.0827282074516606 0.760575555362796 -0.413685847404539 0.124582560893933 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPL39 0.183345716416861 0.524726512242864 0.819874802684524 0.243718543696479 0.401190965139673 0.730809905097423 True False False False False False False 0 insufficient_or_context_specific +RTCB -0.132891296797552 0.524728088702181 0.819874802684524 -0.0056025173699795 0.979482365331534 0.993885133413776 0.132951955385507 0.71225754736943 0.351674217688526 0.197393524418258 0.484626173074034 0.103135264552487 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC41A3 -0.144661408186863 0.524862903007698 0.819874802684524 -0.151570400459085 0.504896282671124 0.792832263802515 0.203305887557031 0.758504046424184 -0.26956373960653 0.56186391710334 -0.0662578520494989 0.917064991174959 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDK12 -0.0720633477565294 0.524872074254425 0.819874802684524 -0.0923196487816688 0.411243456341117 0.735291083225579 -0.273641520975446 0.308577854822149 -0.0319590917473286 0.906018364825772 -0.305600612722774 0.211830237885332 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TDRD10 0.178609661589801 0.524943518293936 0.819874802684524 0.111958056550585 0.683602961630063 0.882656239316401 True False False False False False False 0 insufficient_or_context_specific +SKAP2 0.155319758753148 0.525209043481001 0.820049230874409 0.327973536103944 0.184888832005899 0.566634626507485 -0.144826021069631 0.685678336076267 -0.332911095696958 0.232284281291996 -0.477737116766589 0.11150728424137 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LURAP1L 0.286387769984857 0.525241115029244 0.820049230874409 0.226889843043936 0.615667438508129 0.851916120639411 -0.548811867375478 0.156330656546355 0.560095609542627 0.0952803826733387 0.0112837421671497 0.979656673986802 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PSMD14 -0.152850697233324 0.525288212578483 0.820049230874409 0.0108727342841917 0.965359252237377 0.990582362709799 -0.107906409941736 0.781712361034744 0.431666350329085 0.124985105696181 0.323759940387349 0.28022872717716 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC141 0.345619678424812 0.525487460005862 0.820239000996731 -0.304422380470004 0.56237154831047 0.823511623725651 0.429826831865843 0.109996634454539 -0.862390817873859 0.0047780762668747 -0.432563986008016 0.0923888670855275 partial_or_other False False False False False False False 0 insufficient_or_context_specific +G6PC -0.382423372488149 0.525604290245133 0.820300088160844 -0.405312883046225 0.501192730942766 0.790852317036873 -1.1400184821998 0.181626715567711 1.07865936369616 0.156278217605992 -0.0613591185036336 0.945691608554421 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C12ORF65 -0.183982234778856 0.52582814016981 0.8204069017161 -0.0821332470441315 0.782332244517602 0.924647355053618 False False False False False False False 0 insufficient_or_context_specific +TMEM50B 0.153674865093566 0.526035717213017 0.820609500936027 0.191981492367302 0.427221281109847 0.747531038441791 -0.0350987895431391 0.930124083212292 0.109428685774252 0.679963165202719 0.0743298962311126 0.812201448650283 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ANKS3 -0.109980568964334 0.526536642757311 0.820977615101899 -0.0231811760501067 0.894167861880104 0.966191860460739 -0.272975048855104 0.272268488774844 -0.543296702183532 0.0248852963313238 -0.816271751038636 0.006351445639828 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INPP5E -0.201915716933095 0.526540115091336 0.820977615101899 -0.310755378094627 0.327071808662954 0.676489102054191 -0.162927927182749 0.801831613591966 -0.228888422556052 0.62806197945583 -0.3918163497388 0.440993659395929 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DRG1 0.143255006711641 0.527284919141191 0.821042781619483 -0.005400659558332 0.980682741069945 0.994147708134084 0.408851362420618 1.0 -0.133286237299852 0.593072635243226 0.0964974130930025 0.641989600047869 -0.0367888242068497 0.88142566120496 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCOLCE -0.197304293574421 0.527305323861575 0.821042781619483 -0.336561974631324 0.280363956495242 0.642477283866194 0.350882445305681 1.0 0.757563597326442 0.0242049491371423 -0.354343903514437 0.208101365811055 0.403219693812004 0.173807826872228 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MEGF9 -0.15146670346943 0.52730890521884 0.821042781619483 0.0809685649896272 0.736217501161121 0.905836659743516 0.120434524203738 0.2824612090064501 2.0 -0.191410871617529 0.540889102372572 0.544314891725106 0.0394463580733521 0.352904020107577 0.182519804808367 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ETFRF1 0.163669111821744 0.527370475628128 0.821042781619483 0.0512890863911872 0.840447454574859 0.948929978120132 -0.109375813185271 0.784969824287243 0.351589432459265 0.2170249768137 0.242213619273995 0.43631072628396 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COG3 -0.115962543915805 0.5274021732282 0.821042781619483 0.0063874022138311 0.973147784777202 0.99234826109866 0.107741780065257 0.75298944749445 -0.414696033809133 0.107640497622777 -0.306954253743876 0.263159641233053 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FO393415.1 0.470399785131798 0.527599159537683 0.821069135247294 0.14177317797122 0.843481604799606 0.9506514118099 True False False False False False False 0 insufficient_or_context_specific +BRCC3 0.170237226747048 0.527652404115636 0.821069135247294 0.242414184405177 0.37499904810626 0.712838905321506 -0.348755651142952 0.193783979845012 -0.268959551128522 0.251535134070802 -0.617715202271474 0.027055110412112 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NCKIPSD -0.131031915279081 0.527998036409474 0.821485892780906 -0.228034941024406 0.254926643473196 0.619879203544451 0.462828248088056 0.7527282087845101 2.0 False False False False False False False 0 insufficient_or_context_specific +WDR5 -0.138862048009027 0.528183943470943 0.821583938765544 -0.0426927271114972 0.849059364330485 0.953127856970211 0.157667174165341 0.694225155194258 0.0147156594653859 0.967064446935449 0.172382833630727 0.618677561881319 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCN9A -0.258908580530997 0.528216686525906 0.821583938765544 -0.0699647676180133 0.864876916880805 0.958391272020028 False False False False False False False 0 insufficient_or_context_specific +CYP3A4 -0.617979377315204 0.528375036443736 0.821595520705243 -0.636924199733403 0.516436293751164 0.799726369818831 False False False False False False False 0 insufficient_or_context_specific +TTC1 -0.0988060472926361 0.52837976753065 0.821595520705243 -0.11155619150252 0.472450758387333 0.775593712997022 -0.163776358264415 0.603562155863719 -0.108751461920719 0.67862079771191 -0.272527820185134 0.308657601760708 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTHFSD -0.167092148696044 0.528587958513425 0.821798213221137 -0.161375767833107 0.54303746049366 0.814401918734668 0.0310511061722335 0.949033587947504 -0.735471680552292 0.0383543314302739 -0.704420574380059 0.0552351157785077 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTTY15 -0.602176196330416 0.528703897413142 0.821857442415776 -0.928899768768651 0.32539917216196 0.674724889947951 False False False False False False False 0 insufficient_or_context_specific +PRPSAP1 -0.153628411004349 0.528942656883003 0.822043807775503 0.0282265343494116 0.910448061450782 0.972012437182896 0.196590404829622 0.503929789168441 0.0623957816769738 0.812142172346737 0.258986186506596 0.310100188256524 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLFN12 -0.196848677917419 0.529052568752329 0.822043807775503 -0.0450808986089425 0.887495182188834 0.963910516772936 False False False False False False False 0 insufficient_or_context_specific +FBXO46 0.152642175672984 0.529147583666408 0.822043807775503 -0.159636331126602 0.524594797705371 0.804454883685302 0.283634691106159 0.350494329198229 -0.10944193613039 0.6713392888627 0.17419275497577 0.542990362101498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC4C 0.240515701287332 0.529295110892095 0.822043807775503 0.389209502633563 0.306813981192251 0.661696690217148 -0.730467694606108 0.191058435226051 0.875961120982235 0.0651791394524768 0.145493426376127 0.786667559479543 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZADH2 -0.134244363868799 0.52933348865671 0.822043807775503 -0.128247244716128 0.548177303153152 0.816156774016399 -0.0959251026743981 0.805285257305434 0.367260125887466 0.190161805947833 0.271335023213068 0.35835043350933 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAF3IP1 -0.124505058859705 0.529368805556511 0.822043807775503 -0.233247913253918 0.229874389785448 0.601091682478031 0.500059170753605 1.0 -0.210963564512246 0.555354323988795 -0.68777743487006 0.03193937693606 -0.898740999382307 0.0154950776241598 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MSL1 -0.13941117658302 0.529750001080912 0.822287852445116 -0.110403666084103 0.619373888011399 0.853700980368714 0.225104488047975 0.316574471180361 2.0 0.0611786408760885 0.818971893422967 -0.303435925605243 0.120070198729504 -0.242257284729154 0.232021842440865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UGGT1 -0.133888934040216 0.52979191372075 0.822287852445116 0.0658495399527149 0.766383170684039 0.919276700304713 -0.445499536672599 0.068671760648842 0.030740346553256 0.902660460420492 -0.414759190119343 0.0751678250571117 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYO5A -0.12593930551254 0.529819709154915 0.822287852445116 0.0634727451167204 0.760716758585563 0.915734238148068 0.412272468483162 0.240531207146127 -0.710650156819058 0.0295068039663604 -0.298377688335897 0.374433774208528 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SSB 0.130852781580772 0.530118080606996 0.822481512865344 0.147270719681839 0.480082921227244 0.780162456875056 -0.0395413722110289 0.901995164796902 0.0403131369262153 0.872910916761494 0.0007717647151863 0.997913568297218 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAPRE3 -0.113236456983469 0.53033596374431 0.822578034808763 -0.130592021247124 0.470180740215761 0.774115985605889 0.438538779778948 1.0 -0.131117636014659 0.684526472747504 0.0286829409776164 0.92196790965069 -0.102434695037042 0.720632157487446 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EXOSC1 -0.197056592430125 0.530353565673389 0.822578034808763 -0.0796890219978335 0.799495820733382 0.92964200904188 0.012813412924115 0.978775837181156 -0.179933261023985 0.576094170015707 -0.16711984809987 0.647636072391102 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A53 0.115340391639925 0.530414023581934 0.822578034808763 0.241245733060252 0.186243482110296 0.568159077889465 True False False False False False False 0 insufficient_or_context_specific +NLGN4Y 0.570453593413872 0.53052624915923 0.822631243739632 -0.154851977800492 0.863425172987318 0.958391272020028 0.020126772717838 1.0 False False False False False False False 0 insufficient_or_context_specific +SLC35B3 0.154030693905076 0.530856137921919 0.82290105772715 0.203656018527318 0.409154549141139 0.734857324041122 -0.0799881414684074 0.869015643979454 -0.264130698430424 0.426186842736189 -0.344118839898831 0.343353501745064 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CCDC186 -0.10877049490213 0.531500674609027 0.823639486929491 -0.283653262223256 0.0832000663119163 0.464737806591834 0.8730343434045792 1.0 0.379640585949975 0.0819793109066443 -0.669717710231832 0.005440724149211 -0.290077124281857 0.156481494172438 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IDE 0.133653111381868 0.53152574502378 0.823639486929491 0.146741302027066 0.491470226338896 0.785509848901139 0.314041997256755 1.0 -0.379859606979524 0.196782141748784 0.718249283135282 0.0139573704372748 0.338389676155758 0.204637880572879 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF16 -0.176739176947394 0.531769688011804 0.823833362586739 0.183200393721103 0.524839904721717 0.804676662787375 False False False False False False False 0 insufficient_or_context_specific +SENP1 -0.107151712994916 0.532115074962193 0.824153425166419 -0.0227035273082214 0.89630694223555 0.967509323803592 1.16427265551035 1.0 -0.0608699821332293 0.886337907728528 -0.468258902882128 0.115820207207476 -0.529128885015357 0.101826910512985 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZBED4 -0.165309763977082 0.532132401909403 0.824153425166419 0.0457320771114896 0.863469190521943 0.958391272020028 0.599288686696636 1.0 0.552550083575915 0.500340248402894 -0.022006154337113 0.974071613972392 0.530543929238802 0.461507114670765 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUTM2B-AS1 0.183673475026985 0.532214380953842 0.82415949458942 0.34343207286663 0.230884609093351 0.601518427890281 True False False False False False False 0 insufficient_or_context_specific +C22ORF46 -0.18308360340271 0.532398195965621 0.82418767615406 -0.406961131030767 0.149236764453017 0.533583468169136 False False False False False False False 0 insufficient_or_context_specific +LIG4 -0.222006196487822 0.532447933724885 0.82418767615406 -0.26520531071865 0.454062618137662 0.765695541335292 0.587406592316347 0.496921024026562 0.0788869034500776 0.908298745225042 0.666293495766424 0.373230452478448 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BBIP1 0.149573759749676 0.532466768237057 0.82418767615406 -0.0304488716238215 0.90052591460122 0.968057977213875 0.266347174577481 0.469798583970594 0.242444912609391 0.391175780285911 0.508792087186872 0.115707496833731 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOSTRIN -0.30597400683177 0.53267087583955 0.824240578175287 -0.272603275474453 0.579089688655717 0.831827949124047 0.102391185128508 0.825912821786764 -0.309705075295262 0.329989428666063 -0.207313890166754 0.575110439488207 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALKBH3 -0.158962970118763 0.532714482127167 0.824240578175287 -0.056439004167119 0.826020027015183 0.94180555563999 0.297455873824977 1.0 0.108258882930087 0.766315434517561 -0.395007468547677 0.139858737429211 -0.286748585617591 0.326862261950769 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NRSN2-AS1 -0.19791337434293 0.532797915792343 0.824240578175287 -0.112010024497508 0.726336108798099 0.903365569206837 False False False False False False False 0 insufficient_or_context_specific +PITPNM1 -0.408819394755872 0.53290929890331 0.824240578175287 -0.632405507314739 0.317939952675105 0.669888249918929 0.480932318153405 0.16757691276886 -1.15328596936731 0.0039566153281876 -0.672353651213903 0.061019286714691 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFKB2 -0.251958799437726 0.53314325214423 0.824240578175287 -0.072257152568585 0.8604697091941 0.957306553179273 0.351468940237988 1.0 -0.0929677894858719 0.884295687375294 -0.430848557903245 0.326598881251162 -0.523816347389117 0.264210961910111 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPL37 0.178454219136045 0.533194004131348 0.824240578175287 -0.178685931937069 0.515261807464614 0.799314452426005 False False False False False False False 0 insufficient_or_context_specific +SLC6A16 0.143690167001282 0.533203556444138 0.824240578175287 0.177240354570233 0.440412651981447 0.756815882099629 0.0807432908941988 1.0 True False False False False False False 0 insufficient_or_context_specific +SDC4 -0.336978763765797 0.533452749978272 0.824505070161118 -0.83378766005089 0.118963391160448 0.499608386583932 0.4571810546632349 0.31504629567945 2.0 -1.71674755691123 0.0007771576516937 0.998178319357526 0.0114633702662042 -0.718569237553701 0.049771925085325 reversed False False False False False False False 0 insufficient_or_context_specific +SCARA5 -0.484070458099962 0.533628413442725 0.824535165978091 -0.469377648166399 0.54681264760876 0.815603096463177 0.568654543029958 1.0 -2.74428885478754 0.0071625868735323 1.63302944883906 0.0582561658232891 -1.11125940594848 0.135275628399412 reversed False False False False False False False 0 insufficient_or_context_specific +FOXP2 -0.28948366492954 0.533970816515296 0.82455233326452 -0.357922428679631 0.441711090956229 0.758060094004529 -1.64652640838458 0.0981208122347036 0.304264893189576 0.762718521261515 -1.342261515195 0.134296667264054 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIM44 -0.118933555492999 0.534030010879218 0.82455233326452 0.0520852280143776 0.788413272989897 0.926576536501901 0.0720770293046307 0.822325796457736 -0.420007384242627 0.0787833560335079 -0.347930354937996 0.155047948809902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGAP5 0.101318301650126 0.534168129679991 0.824644993882342 -0.015499040193766 0.924267046901497 0.978224179287905 -0.152573780028455 0.68614406247997 0.586770569620651 0.0495016767988875 0.434196789592196 0.155047948809902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAVS -0.139434970014575 0.534323853253841 0.824762409230604 -0.393416011897939 0.0541812811988069 0.419081294430039 -0.620364890290757 0.0335587687300548 0.972360044765173 0.0031563309045581 0.351995154474416 0.167723242600221 reversed False False False False False False False 0 insufficient_or_context_specific +PAIP1 -0.141126716094692 0.534400420680675 0.824762409230604 0.234041987557815 0.32073274682459 0.672472248121257 0.133859757968959 0.585401309489806 0.202962926465809 0.294967657956959 0.336822684434768 0.110213021965614 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA0319L -0.0848109821231156 0.535160782992426 0.825458245904738 -0.119821706350674 0.378922660201953 0.716066842028319 1.07361917412427 1.0 False False False False False False False 0 insufficient_or_context_specific +TBC1D2B -0.105925434345712 0.535175714085214 0.825458245904738 -0.0801433966174469 0.638430061073337 0.863438120767827 0.793447248191603 1.0 -0.524338611006677 0.0794962642487819 0.379994986620755 0.150083290251539 -0.144343624385921 0.615023876099949 reversed False False False False False False False 0 insufficient_or_context_specific +NAAA -0.194573052162045 0.535310302430022 0.825458245904738 -0.0929637667629401 0.767310904128891 0.91954879692023 -0.359635338077294 0.375993054962106 0.276392339554016 0.403908969447294 -0.0832429985232785 0.838355949684886 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZBED5-AS1 0.257819675307436 0.535444957236869 0.825458245904738 -0.0177673082112572 0.964001177937565 0.989935386867005 False False False False False False False 0 insufficient_or_context_specific +MDC1 0.175545272363091 0.535614422665049 0.825458245904738 -0.155186006088817 0.557830193004389 0.821366572837071 0.257934996089185 1.0 0.402102373177162 0.173478267448051 -0.805837578214485 0.0088109125189793 -0.403735205037324 0.155047948809902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL15 -0.221196163074255 0.535712906106829 0.825458245904738 -0.470039676392131 0.17032752327177 0.550786520889233 0.145488339687114 0.805465548476866 0.0549107759500195 0.904077859613793 0.200399115637133 0.677393444057004 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SELENOS 0.123268138804811 0.535770611084967 0.825458245904738 0.0214098918019986 0.911673557915694 0.972660612820725 0.252205779832276 1.0 -0.178423811144143 0.5934438481956 0.214421185422957 0.424655857380843 0.0359973742788141 0.914303488274021 partial_or_other True False False False False False False 0 cross_species_direction_conflict +UBE2E2 0.141818348271173 0.53579866854603 0.825458245904738 0.383043639715878 0.0865314772719475 0.467677448123587 0.112477635231391 1.0 -0.582958591463884 0.131714135973816 -0.213473668856658 0.538279368387565 -0.796432260320542 0.0396757426500509 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PAXIP1-AS2 -0.163545262382447 0.535874190082962 0.825458245904738 0.126694747853378 0.654446962167602 0.871001011794472 False False False False False False False 0 insufficient_or_context_specific +TPM2 0.279611051377577 0.535945849183271 0.825458245904738 -0.18402375498076 0.671164856525353 0.876782795742969 0.987827826280066 0.0150020259730402 -0.910311951740654 0.015981885398292 0.0775158745394126 0.844689339527927 reversed False False False False False False False 0 insufficient_or_context_specific +CRLS1 -0.15930416920134 0.53602629819179 0.825461735167578 -0.0328380141135376 0.898409010328943 0.967837995533705 0.0897945752803806 0.905635919257768 0.408228149245063 0.384470154118706 0.498022724525443 0.345685744571063 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDRGK1 -0.191298511510884 0.536308249897856 0.825559675567284 -0.326256415432974 0.288721439455985 0.648310091921223 -0.801775570509891 0.0538770279252597 0.420793983977881 0.240437364206748 -0.38098158653201 0.3086420834545 reversed False False False False False False False 0 insufficient_or_context_specific +AC127526.1 0.218117178040345 0.536338269241969 0.825559675567284 -0.13282860677694 0.698492517032575 0.889371148052465 False False False False False False False 0 insufficient_or_context_specific +RPRD2 0.116596668017799 0.536347480992277 0.825559675567284 0.17078000590442 0.357965121781419 0.701446873750598 0.357345041287664 0.382059241162629 2.0 -0.352281987836267 0.14002136468211 0.15723474725541 0.451201653045706 -0.195047240580857 0.375253562125504 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CBX6 -0.124394205256912 0.536609653628281 0.825742443128157 -0.0276616538971315 0.891256368741709 0.964971026865863 0.920593318560476 0.335075610383956 2.0 0.348894228260607 0.344536507202279 -0.846636875843872 0.0182216376222349 -0.497742647583264 0.15062366870391 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLCN3 0.138834009899016 0.536677840949556 0.825742443128157 0.153289189706776 0.494850052780933 0.787315680720477 -0.147051525170941 0.613199845518292 -0.0566305218563928 0.820092676833982 -0.203682047027334 0.408506477182248 partial_or_other True False False False False False False 0 cross_species_direction_conflict +VNN3 0.384491311115002 0.536836708867803 0.825746208074922 0.420571760102979 0.501041467011238 0.790819493321426 -0.84310588543721 0.0978607520875192 1.0451457586479 0.0276908286437771 0.202039873210685 0.67455317797531 reversed True False False False False False False 0 cross_species_direction_conflict +EPC2 -0.0945604335308304 0.536940759892045 0.825785949445041 -0.070635308688495 0.644827850291102 0.866610545235928 -0.230932672155943 0.547980313313899 0.358073471558728 0.232386808404619 0.127140799402785 0.717627569281498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EDC3 0.115466040912243 0.537699255023961 0.826207143049024 0.0651930033537729 0.726102668486363 0.903365569206837 -0.0274825651103291 0.955926757389955 -0.0555736016125405 0.882622588192181 -0.0830561667228696 0.836009073579586 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PTDSS2 0.132680152980711 0.537705131725284 0.826207143049024 0.0756393745643427 0.726604574537591 0.903365569206837 0.3888378141794671 1.0 -0.184309608805695 0.680138276447243 0.283801783228416 0.383912031028419 0.0994921744227207 0.803881669345041 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC17A5 -0.1320449381792 0.537762406424786 0.826207143049024 0.116637675182418 0.593997811322434 0.839773552750704 0.234574207578392 0.699843828596918 0.254164532081755 0.559075740544916 0.488738739660147 0.318533394161975 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNRNP40 0.140068347156936 0.538014362498017 0.826341236989805 0.211673625855738 0.349041490197191 0.694288655897113 0.565283981028774 0.318030941542331 2.0 -0.26528985536155 0.415382455534496 -0.0033372557263843 0.992056018337067 -0.268627111087934 0.353742845537219 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TPD52L1 -0.237692565769122 0.538092511155542 0.826341236989805 0.0663423397271848 0.861705336020819 0.957822965712685 2.04544808816227 1.0 -0.526359905624705 0.356460533039957 0.730220721009942 0.103708434757499 0.203860815385237 0.69469544116432 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPB41L1 -0.210213856792593 0.538268888022805 0.826341236989805 -0.0583576801781163 0.864193956781208 0.958391272020028 3.37862345564188 1.0 -0.883724762257609 0.0314799982455891 0.417649887132866 0.224133527279813 -0.466074875124743 0.194062992971038 partial_or_other False False False False False False False 0 insufficient_or_context_specific +R3HDM1 0.106285386117368 0.538431721946966 0.826341236989805 0.156732016769977 0.362025707639825 0.703533322359016 0.0971662713017504 1.0 -0.0863999502008695 0.768507845084923 -0.864542175504521 0.0037163186079269 -0.95094212570539 0.0037751301772955 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BECN1 -0.138723936980488 0.538432505356674 0.826341236989805 -0.345958099939515 0.104803224823004 0.481930508571983 -0.122259715913868 0.60497543431949 -0.418332123326884 0.0414546877133792 -0.540591839240751 0.0198502247645371 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLIC1 -0.258217683458119 0.538475820277502 0.826341236989805 -0.225439010056192 0.592937775189769 0.838948945383755 0.316403220274572 0.336684213763898 -0.0006434959910087 0.998530909888025 0.315759724283563 0.28948953379064 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA1522 0.391653887730681 0.538708638632691 0.826578376207521 -0.133186453370719 0.827287723932369 0.942259214105446 False False False False False False False 0 insufficient_or_context_specific +LINC01348 -0.396059384309249 0.538949459244891 0.826827723148439 -0.462022980064388 0.472213115798577 0.775593712997022 0.692522265566065 0.34784710115932 2.0 False False False False False False False 0 insufficient_or_context_specific +ADAP2 -0.198612350236899 0.539163512665676 0.827035938794742 -0.187167198217954 0.563360597296826 0.823754286312897 -0.509301658585918 0.244079276398375 0.244352838726476 0.532522982573476 -0.264948819859442 0.520691916165381 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNLS 0.12891180353786 0.539438640243718 0.827165762519652 0.0828444681530106 0.693758473695572 0.887197427964856 0.826759088405229 0.346773905785345 2.0 True False False False False False False 0 insufficient_or_context_specific +TRPM8 -0.429390239400541 0.539561527417393 0.827165762519652 -0.749991825893308 0.26000813182649 0.622885940784012 False False False False False False False 0 insufficient_or_context_specific +FBXO38 0.10744326842161 0.540491271907524 0.828201341009003 -0.0992078427510293 0.563124342178892 0.823754286312897 0.8878666502938449 1.64163591500426 2.0 0.206890091975182 0.480575351919011 -0.255544479087882 0.280154851440426 -0.0486543871126996 0.871078546860795 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTSO 0.212023845656947 0.540913714642721 0.828637115379839 -0.0315798585934673 0.928151496798828 0.979087152943213 1.27767781953279 1.0 -0.331654013530198 0.215523422767541 0.468434555051454 0.0570719481406466 0.136780541521256 0.593527601846861 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RELA -0.189971814291647 0.541324249036377 0.828776980334695 -0.194038134381611 0.533131641636761 0.809783322169604 0.758369600372798 0.734183832159652 2.0 -0.223963679349035 0.369649684210199 0.289222761237551 0.176246985700313 0.0652590818885166 0.792957248993736 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C16ORF58 -0.176004913721248 0.541427358912852 0.828776980334695 -0.236725817829326 0.411898048441443 0.735291083225579 False False False False False False False 0 insufficient_or_context_specific +LZTFL1 0.187387195267055 0.541434037015398 0.828776980334695 0.0994374694162306 0.744585428143655 0.909500945159707 0.3917581071052529 1.0 -0.580997357188591 0.371076058725012 0.819631696960956 0.103904045770326 0.238634339772364 0.681285352656983 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PJA2 0.130726094004066 0.541472534722494 0.828776980334695 0.166118610020027 0.437358264503391 0.754514470037059 -0.13340182466502 0.662380337518893 0.0290366488548582 0.91714860580113 -0.104365175810162 0.701487453439656 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PABPC1L -0.213574126358179 0.541476000222459 0.828776980334695 -0.0632772206074952 0.859446204798386 0.956914759994669 0.0119573401316139 1.0 False False False False False False False 0 insufficient_or_context_specific +AC107884.1 0.134929780489362 0.541655577939887 0.828876469810956 0.0893799185285025 0.682252387913901 0.881775090169539 True False False False False False False 0 insufficient_or_context_specific +TAF7 0.201661291947242 0.541731745168709 0.828876469810956 -0.19818889342958 0.519461203640496 0.801047042355318 -0.622608302828927 0.209483916909758 0.537169431795464 0.19535499274892 -0.0854388710334625 0.866995344852884 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM156A 0.136741021369958 0.542225852943874 0.8290045241503 -0.0182152533256295 0.934771778527486 0.981436002157239 0.298362650822627 1.0 False False False False False False False 0 insufficient_or_context_specific +CCDC159 -0.17728048780361 0.542284049705545 0.8290045241503 -0.177539202246139 0.541866255409597 0.813940850536852 0.35700469735252 1.0 0.0502159737444935 0.932202662560267 -0.814359933197665 0.0515085319770978 -0.764143959453171 0.0849640416547141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM129B -0.183254163420694 0.542407106062141 0.8290045241503 -0.036942400783694 0.905302579085383 0.970253064236706 0.42880583937975 0.162764172242446 -0.474088940994533 0.0817758607106054 -0.0452831016147825 0.893153271154684 partial_or_other False False False False False False False 0 insufficient_or_context_specific +H2AFV -0.150591387717867 0.542443231134686 0.8290045241503 -0.538322730519648 0.0214083260557641 0.340208545646748 0.180340781642262 0.591406277572281 -0.0280379655704464 0.929593400530699 0.152302816071815 0.609216073952331 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GART -0.130653599072513 0.542446425842296 0.8290045241503 -0.107302793428293 0.615918978227016 0.851916120639411 0.174757974388187 0.523162492230053 -0.009039980970646 0.97194630976355 0.165717993417541 0.491699800484276 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TUBB 0.196396945690453 0.542453773133848 0.8290045241503 0.276118435760991 0.39237212098998 0.724495427319379 True False False False False False False 0 insufficient_or_context_specific +SYNCRIP -0.133727888289816 0.542488374441601 0.8290045241503 -0.144004534590523 0.510841821424194 0.796519013040946 0.41336593387468 0.0729089194565824 -0.259206027789807 0.193728450586492 0.154159906084873 0.474094936453626 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HELZ2 -0.216893690352154 0.542724854636497 0.829120218175989 -0.205864040227106 0.564269457196453 0.823754286312897 -0.186441407697421 0.489738865860109 -0.350531332418746 0.12480038066906 -0.536972740116168 0.0360013361442554 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHF7 -0.203549740812508 0.542957787745857 0.829120218175989 -0.088014265453768 0.797827592336722 0.92925379048471 0.182002007412937 0.745995021322483 -0.210378296798698 0.600710240221337 -0.0283762893857611 0.957524478588241 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CPB2-AS1 -0.371610510177463 0.543011280476659 0.829120218175989 -0.233684856083778 0.70739927141981 0.893280888368658 False False False False False False False 0 insufficient_or_context_specific +SLC22A18 -0.343556794247205 0.54319190548826 0.829120218175989 -0.311227497036267 0.583403577298702 0.834132995585234 -0.445096018853082 0.274973819582601 0.343373572151525 0.322265950474667 -0.101722446701557 0.804464118541942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC39A5 -0.34662736379294 0.543193994117126 0.829120218175989 -0.0805028965864833 0.890484826606718 0.964713393362605 False False False False False False False 0 insufficient_or_context_specific +AL121761.1 0.182934565206423 0.543270853318952 0.829120218175989 0.0165324946366558 0.956714319407359 0.987656798648419 True False False False False False False 0 insufficient_or_context_specific +ZFY -0.571480689312856 0.543465133286103 0.82924280553005 -1.09573666518288 0.237152654230592 0.605329180588419 False False False False False False False 0 insufficient_or_context_specific +RASGEF1B -0.173332515400609 0.543508260491376 0.82924280553005 -0.200929852141312 0.480877911014118 0.780346070738476 0.295245722173416 0.263051600995984 2.0 -1.43763754071876 0.0037036563262354 0.852870874553761 0.033329393045582 -0.584766666164995 0.122104384902603 reversed False False False False False False False 0 insufficient_or_context_specific +MYL6 -0.170190480216231 0.543853657644609 0.829649894149947 -0.467505871695919 0.0953170725699969 0.475183542244264 0.131613835082067 0.6553039755011121 2.0 0.773428428140204 0.0080989648790917 -0.63144147019638 0.015199749014023 0.141986957943824 0.57498461610587 reversed False False False False False False False 0 insufficient_or_context_specific +JAZF1 -0.151533249807627 0.544076619875514 0.829709733273765 0.314014509679418 0.238659722537272 0.606415397271769 False False False False False False False 0 insufficient_or_context_specific +UBP1 -0.112968365290567 0.544098369543838 0.829709733273765 0.0065661122742716 0.971999712583496 0.992040338141303 0.143496229775674 0.640640260197348 -0.81112897084447 0.0073009137864842 -0.667632741068796 0.0230210067511911 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EFL1 -0.191243041773506 0.544128641142977 0.829709733273765 0.0762842404151207 0.807338916403021 0.932788199072101 -0.183065520105183 0.617434781370119 -0.235646561327938 0.416829126349437 -0.41871208143312 0.178433457144358 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEMA6A-AS1 -0.148483819397614 0.544255240015126 0.829782934885156 -0.0167824799704811 0.944654265728065 0.985105732892783 False False False False False False False 0 insufficient_or_context_specific +BTN3A1 0.210477775784003 0.544591387935624 0.830153279696144 0.248981481602053 0.475157780065313 0.777182934458493 True False False False False False False 0 insufficient_or_context_specific +CFAP70 0.231144542962851 0.54465540523349 0.830153279696144 0.507978407742131 0.201435288639442 0.576216193866676 True False False False False False False 0 insufficient_or_context_specific +AC087500.1 -0.146983462767928 0.544750969318121 0.830179089789365 -0.102794252433326 0.672063531660745 0.877088599168621 False False False False False False False 0 insufficient_or_context_specific +CNPY3 -0.290165471956778 0.544962244070647 0.830350632936341 -0.423768043413203 0.365045659137004 0.706387878106228 0.291813612221082 1.0 -0.350980061763213 0.151786134903482 -0.133657869621417 0.541859204287452 -0.48463793138463 0.0451184617036066 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANK3 0.155926018409341 0.545020826505858 0.830350632936341 0.195668395759314 0.44573776703066 0.761012183749952 0.611465006552683 1.12627245283219 2.0 -0.78654393823066 0.0790242923464276 0.688902702891703 0.0889308090723821 -0.0976412353389577 0.83294338016607 reversed True False False False False False False 0 cross_species_direction_conflict +ZNF432 0.116654107263819 0.545291719182527 0.830606709041719 0.0543201740871652 0.77823789262165 0.922929913000972 True False False False False False False 0 insufficient_or_context_specific +ING5 -0.120814103770774 0.545346249959954 0.830606709041719 -0.203212090850423 0.302729150921478 0.660051093047527 0.26540111873331 0.4219306654538029 2.0 -0.229911295624811 0.519012541492431 -0.481197689596931 0.105514090194222 -0.711108985221742 0.0370360923115696 partial_or_other False False False False False False False 0 insufficient_or_context_specific +L3MBTL1 0.173591082119262 0.545481658734382 0.830619832033387 0.105903196502919 0.71248443682461 0.895497343705388 True False False False False False False 0 insufficient_or_context_specific +SETD3 0.0902643949445981 0.545512210202643 0.830619832033387 0.21024054243815 0.150857856969173 0.533690850143514 -0.282638875474708 0.233710040860128 0.0316815998425984 0.896142875380252 -0.25095727563211 0.249872646848821 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GMDS 0.156057147897164 0.545607224238915 0.830644711393577 0.420604396575324 0.0856314876572938 0.467503293000484 0.06677711403914599 1.0 -0.258599132385927 0.5826910238579 -0.0742776558831796 0.85895636021494 -0.332876788269107 0.408506477182248 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL356272.1 0.292853908863663 0.545974244520816 0.830963827829145 0.252960024888401 0.602657729989489 0.844795507123598 True False False False False False False 0 insufficient_or_context_specific +AL449266.1 0.156041741109186 0.546227235627275 0.831229050699448 0.0835820133217853 0.74696253029278 0.909830759894547 True False False False False False False 0 insufficient_or_context_specific +ERICH1 -0.143955685144951 0.546602951827647 0.831561090114741 -0.316564729541008 0.180689226999409 0.563538010872213 -0.185563837101598 0.680798649240649 -0.330734896814116 0.332280183773539 -0.516298733915714 0.173570490528706 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL031428.1 0.13190356077335 0.547132774760049 0.831767866942634 0.331206099073107 0.149609316937302 0.533583468169136 True False False False False False False 0 insufficient_or_context_specific +MPC2 0.203356370071565 0.547241684827997 0.831813663750935 0.620698782781197 0.0649875774313589 0.435367285863126 0.0078730670570771 1.0 -0.144402860758625 0.841745367226284 0.909043691310452 0.0841941670469924 0.764640830551827 0.155571091070296 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ESYT1 -0.144143610700594 0.547838400613919 0.83233811757605 -0.26812670942672 0.255424834148688 0.620277236994661 0.18641104857022 1.0 0.577890335158538 0.034594375682796 -0.457393768896488 0.0583257243490327 0.12049656626205 0.644173744624994 reversed False False False False False False False 0 insufficient_or_context_specific +TOM1 0.137222203026818 0.547860307211851 0.83233811757605 -0.0736325364261513 0.754099144029475 0.913618862571469 0.7684267064568009 0.536300070402687 0.0409318814620519 3.0 0.14666752583709 0.67711571393548 -0.284901566433823 0.283105821907691 -0.138234040596733 0.656279380088085 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFKBIA -0.152940302023706 0.54790087388305 0.83233811757605 -0.379461516555912 0.103312940453885 0.47952541118609 -1.33313679390212 0.0037749271380241 0.957140655565894 0.0154875011331035 -0.375996138336222 0.288154357663003 reversed False False False False False False False 0 insufficient_or_context_specific +NDUFAF8 0.186242669186989 0.548153836886634 0.832479100010972 0.147153365315973 0.634978245138918 0.861847932958146 -0.47830765967605 0.103194032556337 -0.121545951399717 0.652313040659312 -0.599853611075767 0.0398222967945456 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BX890604.1 -0.208940147336032 0.548246883267118 0.832479100010972 0.150137475230983 0.670954571129342 0.87672504479995 False False False False False False False 0 insufficient_or_context_specific +NDUFB1 -0.124281976830932 0.54832782233169 0.832479100010972 -0.213113673168439 0.307005219042647 0.661701213710167 False False False False False False False 0 insufficient_or_context_specific +DNAJC21 0.142475546065863 0.548533403868626 0.832479100010972 -0.0903712804789932 0.689491690350285 0.885064226956633 -0.313897178733037 0.245032192157699 -0.381431860273811 0.113656356665708 -0.695329039006848 0.0175044721399198 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM174A 0.175669149096028 0.548604908539508 0.832479100010972 -0.121495523866685 0.67655503221718 0.879146834479876 -0.251669168003111 0.402481427307569 -0.305606480553513 0.229466096723946 -0.557275648556623 0.0518777867306521 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MUM1 -0.106782363765621 0.548675183713297 0.832479100010972 -0.111554476038276 0.530667687894334 0.807748490043731 False False False False False False False 0 insufficient_or_context_specific +ZNF234 0.155961374680278 0.548704494883155 0.832479100010972 0.0545275378542579 0.835159495332713 0.94640055293794 True False False False False False False 0 insufficient_or_context_specific +AC025283.3 0.198603375814494 0.548831483738078 0.832540666696874 0.223039840487089 0.501803745023167 0.791343381621299 True False False False False False False 0 insufficient_or_context_specific +COMMD10 -0.0788817975471039 0.548923547448595 0.832540666696874 0.105805302985646 0.424041563624074 0.745302285457461 -0.294496973935898 0.495967009765683 -0.383823353785983 0.280487442046294 -0.678320327721881 0.0869800467584382 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DHFR -0.139720677044535 0.549126441375687 0.832640667534756 -0.328339220206048 0.134073871339898 0.520900171021663 -0.172842247029005 0.721947920693826 0.670951238169804 0.0657719812495692 0.498108991140799 0.192592617268648 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPR153 -0.279307070031302 0.549784924492923 0.833399746273694 -0.316075085441203 0.497934110017831 0.789518614144207 0.474175480999246 1.0 1.35775948365843 0.0009201172757891 -1.06749017977041 0.0030935322270901 0.29026930388802 0.320301380726494 reversed False False False False False False False 0 insufficient_or_context_specific +RAB34 -0.176717827778811 0.550024911463189 0.833571221917419 -0.147168342445678 0.619712462011805 0.854056151144842 0.4915686718566 0.371626121743449 -0.37227688151078 0.411605711540251 0.11929179034582 0.833368204816258 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COPS7A -0.139516519710785 0.55005594838972 0.833571221917419 0.129119550635535 0.553330898071422 0.819364322838439 0.199602841354454 0.495330805341603 0.199487032818685 0.399049564634153 0.399089874173139 0.121055811904412 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF789 -0.161275709551903 0.550171588074038 0.833626812124812 -0.341984127302426 0.182244497755988 0.56456240235188 0.6285973359998679 0.513990147369756 2.0 False False False False False False False 0 insufficient_or_context_specific +SLC16A10 -0.335217945027478 0.550455178545728 0.833732944865146 -0.247318116406707 0.660886140792579 0.872640804713363 -1.83271574842934 0.0002438424789695 1.12506911821489 0.0040861810681756 -0.707646630214449 0.0328385135242499 reversed False False False False False False False 0 insufficient_or_context_specific +ZCCHC8 -0.0801082749498767 0.550478533685824 0.833732944865146 -0.169005384445038 0.204911748908148 0.578464771382949 0.169954077363777 0.633078737781183 -0.387182759396749 0.167786139537494 -0.217228682032972 0.477096550569562 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTTY10 0.555342169975954 0.550843158086295 0.834165528266653 -0.0661514457124711 0.942708644948446 0.984366565940656 False False False False False False False 0 insufficient_or_context_specific +CYP2B6 0.707394279747964 0.551095130335456 0.834233553001064 0.520327898364578 0.660400108842238 0.872407073022888 True False False False False False False 0 insufficient_or_context_specific +AC021739.2 0.243442014546032 0.55131951871947 0.83428858802353 0.174815269164738 0.667435650603212 0.875419277100913 0.0381550469572787 1.0 True False False False False False False 0 insufficient_or_context_specific +ORM1 -0.321026893050593 0.551501521654505 0.83444440608029 -0.300035667717221 0.579366212885727 0.831827949124047 -1.62075293525681 0.0036044741243049 1.52591508704598 0.0046641092992809 -0.0948378482108346 0.844250662838368 reversed False False False False False False False 0 insufficient_or_context_specific +QKI 0.0935491916572717 0.551828424411319 0.834605765305838 0.245200835749557 0.119807037051256 0.500502724013779 True False False False False False False 0 insufficient_or_context_specific +MIS12 -0.182694056619341 0.551845316120482 0.834605765305838 -0.228694927367482 0.449944003350976 0.763939182518913 0.418254003387256 1.0 0.302075785920881 0.550993086227461 -0.113017364892308 0.785348172566939 0.189058421028573 0.687588961748141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFU1 -0.149119802080655 0.552116496118828 0.834755148669839 -0.0914968761778333 0.716532130077044 0.897727094974894 0.0704150431062534 0.856860196217495 0.245158416485958 0.334996717035506 0.315573459592211 0.26552257421949 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SART3 0.133096023819481 0.552158073561084 0.834755148669839 0.0030284653238388 0.988697569975811 0.996718493722613 -0.38344373331906 0.148757698730074 -0.622454900926145 0.0195053385632711 -1.0058986342452 0.0037813450480798 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARHGEF26 0.246606813301091 0.552242188670405 0.834755148669839 -0.199483488295738 0.63631477431361 0.862000078223965 0.94972987338673 1.0 -0.879289288971468 0.0690148515828702 0.70272725697164 0.0979350016209224 -0.176562031999828 0.70533188099601 reversed False False False False False False False 0 insufficient_or_context_specific +RYR2 0.300511324552717 0.552647273264707 0.835034949552162 0.560151149630665 0.257607374989149 0.621906676979798 0.300578772749569 0.32407592695327 2.0 True False False False False False False 0 insufficient_or_context_specific +ESS2 -0.268729136483367 0.552785297851152 0.835070421335307 -0.807488741638946 0.0529974359254671 0.416329559896638 0.0688793815435349 0.912863180790051 -0.261959789328564 0.515542940056833 -0.193080407785029 0.694212395639852 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC9B2 -0.163768779467805 0.553160876836692 0.835192232963259 -0.0308226670426416 0.911653819400621 0.972660612820725 0.331123277394055 1.0 False False False False False False False 0 insufficient_or_context_specific +HAAO -0.243756403320156 0.553179196000303 0.835192232963259 -0.204684468507963 0.619847982643884 0.854057426504748 0.273021068936897 1.0 -1.09396162205092 0.0145779809135334 1.17976541921469 0.0083083886960038 0.085803797163769 0.841757393942021 reversed False False False False False False False 0 insufficient_or_context_specific +EGFR -0.129873293414179 0.553182353202507 0.835192232963259 -0.194944208844728 0.373333270142767 0.711746599163477 0.508579893220526 1.0 -1.76199230454968 0.0021630872412973 1.66711456495907 0.0030507204347802 -0.094877739590616 0.841222559462295 reversed False False False False False False False 0 insufficient_or_context_specific +CDK13 0.0856518581357506 0.553352423945941 0.835225837953313 0.207794286764095 0.139953543923963 0.525466309117542 -0.027507206433903 0.928595190847574 -0.0004200859472325 0.998693746778008 -0.0279272923811356 0.912693703295319 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HOOK3 0.0901470847095662 0.553395832843192 0.835225837953313 0.182933999032015 0.233760802636999 0.602697571243329 0.0776980733879878 1.0 -0.183347777764409 0.47133043795982 0.235902272176099 0.261225533143561 0.05255449441169 0.835079808114702 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CA5B -0.12408601512487 0.553441936192591 0.835225837953313 0.2230919616278 0.279509366234922 0.642114507827558 0.542107308485394 1.0 False False False False False False False 0 insufficient_or_context_specific +SCRN1 -0.197514174346248 0.553813169038761 0.835326442071061 0.116417271759455 0.729590121583242 0.904204533048315 False False False False False False False 0 insufficient_or_context_specific +GRAPL -0.350637102887207 0.553825070515006 0.835326442071061 -0.715295058852405 0.217759056606184 0.589966671708516 False False False False False False False 0 insufficient_or_context_specific +AOC3 0.284661211813062 0.554128147553188 0.83566418823976 -0.497241197336672 0.293027500753196 0.651509781962399 False False False False False False False 0 insufficient_or_context_specific +BPTF -0.0836131847088479 0.55422259550871 0.835670277946212 -0.101400086952633 0.470231890386572 0.774115985605889 0.4861775505195229 0.290891244695655 2.0 0.135598353999155 0.633404810621864 -0.310161976339975 0.171548362140436 -0.17456362234082 0.470258126377245 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYDGF -0.209506141704493 0.554290486499084 0.835670277946212 -0.0242021784810498 0.945770261152211 0.985432868134933 -0.270042728794266 0.445370591747454 0.4606414703515 0.125124584889359 0.190598741557235 0.554097025513333 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF674 -0.161489614264979 0.554507974118198 0.835759484759448 -0.399428854894994 0.113867085553822 0.4924007041452 False False False False False False False 0 insufficient_or_context_specific +CHCHD3 0.119737576948967 0.555111867552824 0.836430868791596 0.322527853798107 0.0897441820115331 0.470746198832535 0.3845879641730229 1.0 -0.548746791384754 0.0366405655749477 0.259616881666245 0.245503949114496 -0.28912990971851 0.217323010702791 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AQP7 -0.367599074320304 0.55541630004663 0.83653142594755 -0.487771056784976 0.428095123227425 0.74799415349718 False False False False False False False 0 insufficient_or_context_specific +SAMD3 0.475475841138715 0.555596286856551 0.836575795086625 0.812236715185701 0.315602442861432 0.667895488420725 1.02899322930996 1.0 True False False False False False False 0 insufficient_or_context_specific +FGD5-AS1 0.144550763191832 0.556310565154195 0.837400477173936 0.0695908850621585 0.779093150483343 0.922987599057803 True False False False False False False 0 insufficient_or_context_specific +AHDC1 -0.132744515771336 0.556475110520675 0.837418267735444 -0.0129633579942751 0.955121992270258 0.987410276805219 0.555072882984057 0.587494953301822 2.0 0.205568820306864 0.386319666550372 -0.145910900603137 0.473005402535105 0.0596579197037273 0.801155814915589 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFYVE21 -0.15787497724739 0.556560331947302 0.837418267735444 -0.275835175356067 0.298371174413802 0.656565831484144 -0.241023059901523 0.346191131128085 0.451580634628987 0.0515085319770978 0.210557574727464 0.36167345898242 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC012363.1 0.291693447196773 0.557007465626539 0.837971618991879 0.199361843329378 0.687654598595672 0.884451344908836 True False False False False False False 0 insufficient_or_context_specific +AC240274.1 -0.258158703594096 0.557258023880182 0.838229123255017 -0.720373553954525 0.0946978278129535 0.474551164587418 False False False False False False False 0 insufficient_or_context_specific +MED16 -0.184255914255889 0.557957415187672 0.838922584669815 -0.180833336838772 0.565990263319033 0.824113119711934 0.455201093891061 1.0 0.171320065220573 0.693510284056211 0.134466184910648 0.693163553930913 0.305786250131221 0.391579376108947 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZBTB43 -0.121504514419686 0.558158834196702 0.839045913251263 -0.0764676720481038 0.712948300577081 0.895497343705388 0.085501369340195 0.833103407081154 -0.178744412910194 0.528553607027549 -0.0932430435699995 0.78370087562633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SERPINA6 -0.222134688011851 0.558274238042729 0.839045913251263 0.271447267588768 0.476614468443945 0.778118997654425 -0.520096173827253 0.320505518455542 1.18371961254473 0.0178272488462107 0.663623438717477 0.153424042629718 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL589843.1 0.237777921446271 0.558357320184067 0.839045913251263 0.225755394733151 0.579268742741496 0.831827949124047 True False False False False False False 0 insufficient_or_context_specific +NIPA1 -0.15003012998203 0.558719450953545 0.839451714011859 -0.124543097546259 0.62887524495246 0.858472266510466 0.759547597799549 0.109165896250983 -0.35847855685358 0.334391971784095 0.401069040945969 0.37135754729829 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DENND1B -0.130057290513767 0.558786384360233 0.839451714011859 0.080862925581338 0.711012718390728 0.895167216881625 -0.368177908184637 0.149394353934129 -0.201391312367568 0.367186453595652 -0.569569220552205 0.0298248636211815 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR47 -0.16057863876698 0.559111990729488 0.839653314432678 0.140285378533344 0.623873238203626 0.85594302057622 0.0441157089828281 0.944536385092652 0.316943726025414 0.411105018964691 0.361059435008242 0.413975136282197 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF785 -0.132881065531634 0.559279243872925 0.839653314432678 -0.0406694959325586 0.85774804552936 0.956914759994669 0.711879975532093 1.0 False False False False False False False 0 insufficient_or_context_specific +ZSCAN32 -0.150228772862977 0.559307484623042 0.839653314432678 0.0669761816148183 0.790233504184117 0.927375594093834 0.4488774726935471 1.0 False False False False False False False 0 insufficient_or_context_specific +BTN2A1 0.146519925715435 0.55952610816001 0.839653314432678 0.255054674784615 0.305542873631811 0.66159180881966 True False False False False False False 0 insufficient_or_context_specific +ZNF385D 0.541514652746387 0.559549005316944 0.839653314432678 0.45231719915482 0.623247220396928 0.855452720082907 True False False False False False False 0 insufficient_or_context_specific +PIAS3 -0.175475126685812 0.559556802457693 0.839653314432678 -0.0319690000738367 0.917289036647518 0.975930957742715 0.0537068547808857 0.880894926276994 -0.735992774580132 0.0119325691705398 -0.682285919799246 0.0235198968227419 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATAD5 -0.117195625650343 0.559703079222501 0.839753461763701 -0.127983064801544 0.523712620555866 0.80370058056999 0.536425196272518 1.0 1.09456454327618 0.194875180701346 -0.452990364599257 0.45866253403565 0.641574178676919 0.435883614454644 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRPPRC 0.0805613640512354 0.55989252839996 0.839918345388858 0.174151153666791 0.199996721649199 0.575358416123227 0.360725401262658 1.0 -0.359994473415801 0.25733954313929 0.23465182635117 0.396089173650767 -0.125342647064631 0.688030642577983 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM192A -0.0900387500215647 0.560177552057474 0.840014411747303 -0.119904741892274 0.440586226526537 0.756990948684651 0.346134810094985 1.0 -0.282763661260639 0.325017572953707 0.0934449373840297 0.718150415195762 -0.18931872387661 0.47402072727143 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCRN3 0.141338173569175 0.56042891028457 0.840014411747303 0.137007078291867 0.572626771132919 0.827730374888659 -0.745364949627817 0.0162350617276294 0.613983722173732 0.0275141481921254 -0.131381227454084 0.637680830785163 reversed True False False False False False False 0 cross_species_direction_conflict +SUGT1 -0.114704292483938 0.560467155986409 0.840014411747303 -0.107889310650348 0.583922642816127 0.834132995585234 -0.133268550410904 0.656551066799039 0.370332446154404 0.111174498237208 0.2370638957435 0.33302849793973 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPUSD4 0.198765335594222 0.560476643109107 0.840014411747303 -0.0543517150635677 0.873059538502529 0.959263070839262 0.359060557854904 1.0 0.106308480224827 0.883360367629338 -0.883813026325748 0.0833876778808826 -0.777504546100921 0.171513141985865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZC3H14 -0.102596658399164 0.560499014924048 0.840014411747303 0.0218618621880743 0.902156344134305 0.968870580955141 -0.0882758816922816 0.817450599270905 -0.0750528274748792 0.799066291308423 -0.163328709167161 0.590974300243057 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRKCE -0.11672982561382 0.560513499787815 0.840014411747303 0.0339795823469904 0.860678300401165 0.957336862161347 0.6860442091131291 1.0 -0.350780451158425 0.220638627693788 -0.423736579482299 0.101370082051278 -0.774517030640724 0.0147577580470922 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACTR3B -0.15348439774716 0.560708541969845 0.840140057594203 -0.0551371749716199 0.839092039129629 0.948312325961317 0.0211488112055419 1.0 -0.684795809365964 0.260138341484267 0.776624142844293 0.113916446776431 0.0918283334783289 0.880479397049426 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NCOA1 0.101624372103003 0.560967282463963 0.840140057594203 0.123730261986562 0.47591507917091 0.7778191030784 -0.20960737636263 0.626249615505296 0.409285846540305 0.210088397436637 0.199678470177675 0.589535480158036 partial_or_other True False False False False False False 0 cross_species_direction_conflict +POLDIP3 0.125031818456599 0.561062602513851 0.840140057594203 0.108364689602949 0.612920419784058 0.850256876199477 -0.243436942786111 0.438577085261165 0.220192299527714 0.400199186450768 -0.0232446432583974 0.94255004705772 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC002066.1 -0.252135708574243 0.561137656405107 0.840140057594203 -0.596854704854469 0.165647895247327 0.545468009482397 False False False False False False False 0 insufficient_or_context_specific +THUMPD2 0.127555545153407 0.561370766402094 0.840214477157487 0.210789861328952 0.337906053534392 0.685815477357961 -0.0911989950525755 0.88300496427381 -0.137830452766378 0.750020192306215 -0.229029447818954 0.633944137613951 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NUDT9 0.12178823167474 0.561442805109497 0.840214477157487 -0.0183797419314945 0.929846305163818 0.979967786975403 0.0233074148929608 1.0 0.163399975908311 0.604968023577395 0.116541469074756 0.653888085647089 0.279941444983068 0.292666137145593 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SAA2-SAA4 -0.414509664948299 0.561684795861837 0.840362578916522 -0.66958121117314 0.340361132293078 0.687922789857293 False False False False False False False 0 insufficient_or_context_specific +SELENOI -0.134229195859615 0.561700958459358 0.840362578916522 -0.194422527880139 0.398950965656158 0.728993474454433 0.580849189193757 0.5305795405018641 2.0 -0.401551547889331 0.312600961588425 0.0864458802514212 0.815512936197724 -0.31510566763791 0.382540648301865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GRIA3 -0.294355998095773 0.561886007227937 0.840401255746219 -0.0812991983613991 0.871802309973431 0.958683313195135 2.03835102079448 0.0379613254210517 -0.789352896813791 0.196151448503904 1.24899812398069 0.196571525387654 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TP53INP2 0.342354888129862 0.56198554252014 0.840431070527995 -0.428736433174544 0.4607354168366 0.768757248799843 0.6689960517142289 1.0 False False False False False False False 0 insufficient_or_context_specific +CPNE1 -0.0989679071983696 0.562212813830273 0.840521671356468 -0.0518797234143664 0.756090616014861 0.914440101763119 0.278114809308095 0.43818386322322 -0.358628378333462 0.222386479179962 -0.0805135690253672 0.823276202435986 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WASF2 0.0825583986308262 0.562381337367504 0.840521671356468 0.0870526407103934 0.539940370676763 0.812783927483158 0.474398606944189 1.0 -0.0421459754212218 0.901577906130256 0.287879740761769 0.208860241474794 0.245733765340547 0.311212033601955 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BCO1 -0.422255255361023 0.562419965501084 0.840521671356468 -0.913058370386084 0.18987145289828 0.569886897607216 0.444079809266498 1.0 -0.232318408002249 0.609771106273004 -0.0250814829919074 0.952558027623544 -0.257399890994156 0.512377477402176 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAD17 -0.0998200678266244 0.562444175803509 0.840521671356468 -0.0536124312872227 0.758060717066354 0.914906841653699 0.195232839838827 0.601822017971327 -0.422094478399888 0.148332519763611 -0.226861638561061 0.491359817955116 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HERC4 0.0730709486432207 0.562980559207764 0.840988900786039 0.102828398004273 0.408410533157138 0.734801770489731 -0.0714784953099088 0.82012363773682 -0.455371754685893 0.0561118366761951 -0.526850249995802 0.0411712952532249 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ITPR3 -0.142451012945038 0.563065059379004 0.840988900786039 -0.0880879418033907 0.719860193320494 0.899654820203335 -0.406239789032757 0.461854771848736 -0.124367278637258 0.796988966205911 -0.530607067670015 0.278328132319744 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATG12 0.0991199347525926 0.563140782490302 0.840988900786039 -0.0460106108592998 0.791355035998195 0.927588847807277 -0.185221673609723 0.680138276447243 0.137608327978981 0.699014934247541 -0.0476133456307425 0.912183542250547 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC099489.1 0.222824900546321 0.563155098366859 0.840988900786039 0.0722661330746145 0.849525467428224 0.953127856970211 True False False False False False False 0 insufficient_or_context_specific +PALD1 0.270062746560587 0.563511380232233 0.841237948542153 0.585712791600773 0.221915496322738 0.593310663503536 -0.583385210658321 0.103372739355657 0.0020569414073322 0.996161503721905 -0.581328269250988 0.0870656032544512 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CYBA -0.165213933171325 0.563527354619026 0.841237948542153 0.0671484245052897 0.820131501670046 0.937826101443988 0.36496539166716 0.3955403941374 0.203812453405085 0.561826889868455 0.568777845072245 0.140341825182039 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EBAG9 -0.128583252983233 0.563560902636735 0.841237948542153 -0.133977716714017 0.547077712006813 0.815603096463177 -0.177723358036184 0.518497297421777 0.0475466941337201 0.848386172268916 -0.130176663902464 0.600107432608579 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPRA -0.0749934631519189 0.563908698776069 0.841316109027778 -0.0783772739247491 0.543846597072439 0.814920858911554 0.00583888527852694 1.0 0.154328063854782 0.604968023577395 0.224042866110928 0.337305945454733 0.37837092996571 0.135706541183585 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CERS5 -0.0973994191085139 0.563982369542784 0.841316109027778 -0.174263134347013 0.286490792956357 0.64687121300967 0.504543615493761 0.166284511091919 -0.497042175959395 0.110334776574889 0.0075014395343662 0.985940815654353 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFYVE28 0.167341606884396 0.564011689685415 0.841316109027778 0.209465406916797 0.471597973393265 0.774962086083438 0.0724922864111413 1.0 True False False False False False False 0 insufficient_or_context_specific +MAGOHB 0.180912954753216 0.564533568172727 0.84197561982874 0.135800175693048 0.663048646142597 0.874184266480212 -0.068133758610457 0.944027035712968 -0.209892330790277 0.743708668295424 -0.278026089400734 0.715333627113548 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CMAS -0.138797103765898 0.564868326429839 0.842174424166167 0.107184800735306 0.670739592802612 0.87672504479995 0.025610335904041 1.0 -0.207147962969507 0.459964512056431 0.043556570875697 0.870148171561153 -0.16359139209381 0.517547452823532 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNTA1 -0.20537074233573 0.564943106073874 0.842174424166167 -0.382172735591309 0.264260360927609 0.626979975432292 1.44779016535786 0.563966118126208 2.0 0.0989534178649641 0.77419391088713 -0.101707069756431 0.701163435434613 -0.0027536518914672 0.993999298012455 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AKR1C1 0.303939999989141 0.564985929756484 0.842174424166167 -0.0998533895873898 0.851640721853647 0.95411956083731 1.43050641773799 1.0 False False False False False False False 0 insufficient_or_context_specific +KIAA1671 -0.139923582339382 0.565177396479453 0.842329618277797 -0.315652068961843 0.190567957097354 0.569976343069084 False False False False False False False 0 insufficient_or_context_specific +PRKN 0.115270169013625 0.565303776186032 0.842329618277797 0.113610479931742 0.570308989480982 0.826196804464902 -0.550727191606468 0.122682797342233 -0.189423770938617 0.551910917671635 -0.740150962545085 0.0391192924005971 partial_or_other True False False False False False False 0 cross_species_direction_conflict +APLP2 -0.146374404020057 0.56532938767915 0.842329618277797 -0.121643105198002 0.632410138873678 0.860473275161544 0.0410897735664596 0.930460146649179 0.224109522248995 0.479911478055399 0.265199295815454 0.423934910311592 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADAMTS3 0.229051574965955 0.565497821542589 0.84246169039744 0.384501417409003 0.325195202551618 0.674724889947951 -0.467358211311438 0.239706374458934 0.590460439601762 0.0912632109825349 0.123102228290323 0.756138553093988 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAST2 -0.107518420397066 0.5656484676282 0.842567229291554 0.0567066341024257 0.756802541397311 0.914454644719928 0.519652920547738 0.301864574514243 2.0 0.429946514662706 0.150015127292629 -0.554254234440218 0.0452621311752497 -0.124307719777512 0.678122199165682 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MCUR1 0.146014532527948 0.565915931636314 0.842808157051877 0.216392011589635 0.405699486189282 0.733444811508554 0.566781960241832 1.0 -0.248826498619205 0.564274375022974 0.353349414127321 0.302176211659333 0.104522915508116 0.796970867635169 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TFRC -0.184199999518749 0.566088334506837 0.842808157051877 -0.205241880001719 0.519829644356293 0.801118945922776 0.288263758168599 1.0 -0.0167409364307688 0.979172400074159 0.712922705031724 0.072076198489853 0.696181768600956 0.113031790583674 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKRD46 0.150661319921787 0.566187725061891 0.842808157051877 -0.0404530897460666 0.873840105796797 0.959366781751097 -0.15362589773898 0.595911943878158 -0.107047135824404 0.658688820308847 -0.260673033563383 0.28732002992825 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CSPP1 -0.112267656251224 0.566461567234453 0.842808157051877 0.174996040957226 0.334805293526469 0.684389988199895 0.0050155543534284 0.989165574768777 -0.90941180365789 0.0046059388008239 -0.904396249304462 0.0071027146690786 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL3 0.145980301544147 0.566721827653699 0.842808157051877 0.0156649767520858 0.948154035346545 0.986558618822196 -0.524283582544536 0.194722467158509 -0.307554844044226 0.390459140474398 -0.831838426588762 0.0406130449674951 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CTDSP1 -0.142128997858935 0.566751791545204 0.842808157051877 -0.332274390139965 0.150411599674792 0.533583468169136 0.5745195836602521 1.0 -0.209468277164688 0.447995086999169 0.0946822065219274 0.699628346598099 -0.11478607064276 0.658464393982516 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TLN1 -0.100977153644391 0.56676812986061 0.842808157051877 -0.190901107201002 0.279401727518234 0.642114507827558 0.121252320265939 0.340105968530162 0.0185950867839969 3.0 0.183595151386978 0.542699694788604 -0.0547565941785342 0.842497573899345 0.128838557208443 0.638766995280281 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL021707.1 -0.135433311721638 0.567102889974846 0.843038035002287 -0.226972121944281 0.335464100331894 0.684461073909613 False False False False False False False 0 insufficient_or_context_specific +KCNQ1OT1 0.165155426438845 0.567176594370271 0.843038035002287 -0.138391095869252 0.626551585990124 0.856993346921069 0.615076493484648 1.04154507763876 2.0 False False False False False False False 0 insufficient_or_context_specific +CYR61 0.294945854798705 0.567213659604071 0.843038035002287 0.583070954858953 0.240837368529788 0.608162815336196 True False False False False False False 0 insufficient_or_context_specific +IMMT -0.0915469854209827 0.567245509941128 0.843038035002287 -0.125611949950597 0.423996311198425 0.745302285457461 -0.0484482242657782 0.871088217919342 -0.0830031156852854 0.705189547476624 -0.131451339951064 0.567063628863742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIF27 0.125897870829973 0.567321958580342 0.843038035002287 0.185824071296566 0.397973344175502 0.728473715359454 True False False False False False False 0 insufficient_or_context_specific +CD96 0.256676319738639 0.567611086188167 0.843228524674911 0.0667512423673107 0.878502693791382 0.961432567887278 True False False False False False False 0 insufficient_or_context_specific +ZDHHC9 -0.185877793798119 0.567753349254221 0.843228524674911 -0.284007765955988 0.382731923387355 0.718507811674046 -0.521733934499115 0.0894121768149872 0.723820606747145 0.016828643070805 0.20208667224803 0.474295673545989 reversed False False False False False False False 0 insufficient_or_context_specific +STX17 0.106245968564878 0.567769613744454 0.843228524674911 0.0077862515336347 0.966771390795641 0.990805143378026 -0.231311940039427 0.418699820073183 -0.125727611885027 0.6107129694888 -0.357039551924454 0.163796385556228 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CHAMP1 0.255136248082342 0.56852603188256 0.843747506689109 0.159933219566764 0.717091030743299 0.898001079656951 0.170549389975976 1.0 -0.496464412680858 0.268640494859393 0.299743965882278 0.427004566291826 -0.19672044679858 0.647127625350669 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LARP1 -0.0802010127681229 0.568598551817865 0.843747506689109 -0.0034651810678072 0.980407330695623 0.994014064108846 0.386700025558217 1.0 -0.268185891510434 0.42623387606321 0.129491346998175 0.663038793380911 -0.13869454451226 0.664285548011892 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDX49 -0.198240851888687 0.569143628284477 0.844190298019252 -0.189470646030164 0.587492269414486 0.835274227991216 -0.119405682948683 0.692468360812531 -0.163666192670345 0.486243763554977 -0.283071875619028 0.254976364494686 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TGFB2 -0.2497906829673 0.569221792168374 0.844190298019252 0.105591797218894 0.799249253188617 0.92964200904188 1.07939428606508 0.0109077892864693 -0.527095985115706 0.0968725845300603 0.55229830094937 0.135692348490859 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RECQL5 -0.179896242283793 0.569313036080943 0.844190298019252 -0.221447052666298 0.482255370064034 0.780666906162311 -0.0015882558423588 0.99714076360711 -0.429262387513598 0.19169133034125 -0.430850643355957 0.226041628690408 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1S 0.122625872411799 0.569619032845643 0.844190298019252 -0.0044661138312732 0.983250019921981 0.99451887511202 False False False False False False False 0 insufficient_or_context_specific +TOP3A 0.107691272387922 0.569637216027311 0.844190298019252 -0.0020939559052912 0.991151063260289 0.997505994031947 0.503486773249664 0.352371028537476 -0.633721832311385 0.143139514403731 -0.130235059061721 0.822782243214528 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DHX34 -0.169397359806177 0.569706152395963 0.844190298019252 -0.405964344120067 0.172654674470315 0.553858965567902 -0.166849667421423 0.674273152012007 -0.273583118460018 0.36548410427564 -0.44043278588144 0.183128207011902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ISCA1 0.16990935165618 0.569770270659676 0.844190298019252 0.0966014044881503 0.746676095970889 0.909830759894547 0.0296200293913228 1.0 True False False False False False False 0 insufficient_or_context_specific +BTAF1 -0.074220567272114 0.569847819389904 0.844190298019252 -0.0299677939867453 0.819033559745897 0.937594977362923 0.0910376445270615 1.0 0.0096506102663398 0.981117342485003 -0.341611099495686 0.214147429647772 -0.331960489229346 0.265783258239457 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IQCG 0.132909852938742 0.569856436255277 0.844190298019252 0.336445192877333 0.150261012258736 0.533583468169136 True False False False False False False 0 insufficient_or_context_specific +QSOX1 0.220394126446244 0.570066963795212 0.844383698618105 -0.512407110981818 0.172579738322574 0.553858965567902 0.412635184782264 1.0 -0.538769663695139 0.122682797342233 0.470726739561136 0.130577824994895 -0.068042924134003 0.852322321813942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL645608.7 0.252583679449848 0.570541444502217 0.844709570188752 -0.174857576812233 0.6753282184663 0.878580824298291 False False False False False False False 0 insufficient_or_context_specific +AHCY -0.180673071541447 0.570750526651507 0.844709570188752 -0.0016751395815183 0.995365295388578 0.998795540446485 -1.01600562668858 0.129789422100411 1.86391207456716 0.0075360290018291 0.847906447878584 0.147632966118737 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADAR -0.0938945044184634 0.570913856221546 0.844709570188752 -0.0092658303941512 0.955908189541554 0.987410276805219 0.397346922543648 1.0 0.0848324222434021 0.808539778669722 -0.517513220674976 0.052888688583401 -0.432680798431574 0.113127485709403 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCYL3 0.119127732082641 0.570916227168775 0.844709570188752 -0.0534406602925434 0.803636964634897 0.931474264201915 0.280665572790517 0.392813317099919 -0.168490148960118 0.53318955380701 0.112175423830399 0.728237411702902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC102A -0.224359425848272 0.571073124609853 0.844709570188752 -0.207045312814965 0.603228975209094 0.845016786554015 0.3555230333811571 1.0 -0.16464211859748 0.6634982043799 -0.411255461919945 0.167705559372267 -0.575897580517425 0.0794170333570016 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HAND2 0.177780796054491 0.571086724579759 0.844709570188752 -0.151219478461887 0.607621855696416 0.847236074015156 -0.384049984229184 0.349050879242194 0.255302249586887 0.476647911500677 -0.128747734642297 0.751477221714239 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCNT1 0.110124016645901 0.571123552296586 0.844709570188752 0.0469121997260752 0.809234447363819 0.932943578867351 0.477260497887045 1.0 -0.0781672747754976 0.819489039201702 0.0243794798702817 0.931109715554117 -0.0537877949052159 0.856332495702401 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LARP4 -0.120157666344307 0.571167041255683 0.844709570188752 -0.138317412930701 0.514081226328444 0.798491683514042 0.04767074710415 0.915993062050496 0.414907365056331 0.161577743401439 0.462578112160481 0.146682990889013 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP1R3B -0.286350809366133 0.571326617105834 0.844827230168542 -0.527186901965297 0.299515605583827 0.657713345206747 0.718477250388218 0.0355433294042857 2.0 -0.522786409537144 0.254924206806844 0.32916012045193 0.414520184003729 -0.193626289085213 0.66613947490803 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DCPS -0.20351773560854 0.571535287358995 0.844874967917694 -0.144583418668582 0.691423144004535 0.885824849193387 0.328220921058823 0.337073945094218 2.0 -0.0757443196297142 0.87729124626794 0.0379815163903214 0.920297254387964 -0.0377628032393928 0.928500936767574 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC36A1 -0.166082036260632 0.571692131720772 0.844874967917694 0.0497398927307775 0.866455201067599 0.958391272020028 0.428211692742446 0.117172726940726 -0.945612033986938 0.0033613148639595 -0.517400341244492 0.0566142223171188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITGA11 -0.284815046459491 0.571754967138876 0.844874967917694 0.0586120519761338 0.907525616362263 0.971277796001295 0.0898223591546563 1.0 1.40124709239251 0.0728300718498522 -0.40206422587943 0.470426286240017 0.999182866513083 0.179034788798252 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIM35 0.182517485559764 0.57210902877333 0.844916530219607 -0.0874959986074058 0.778854469886406 0.922929913000972 0.170785019061853 0.374118206959495 2.0 0.03210776691969 0.936257534403958 -0.4531416301579 0.10257547942829 -0.42103386323821 0.146423016846496 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDX21 -0.204411199097205 0.572144279744275 0.844916530219607 -0.314108276257663 0.386743464236276 0.720477739899883 0.0441480131081079 0.905790421240866 -0.0038857220288332 0.989887555928977 0.0402622910792747 0.89756912430398 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DPH6 0.0884871445672489 0.572168067364735 0.844916530219607 0.129918303075744 0.396091786388559 0.726915037383597 -0.79587665422785 0.0865057025048686 0.3153440671281 0.43499345746785 -0.48053258709975 0.253728124196861 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DMAP1 -0.199875787916301 0.572187269470562 0.844916530219607 -0.012811962091744 0.972123889770315 0.992040338141303 -0.351865869993324 0.47290396827114 -0.184211010925387 0.661360613557508 -0.536076880918711 0.217362876290633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NREP -0.23713605206032 0.572391941733747 0.844973897107944 -0.444448969778217 0.28111984290872 0.643133976474597 1.74242465216852 1.0 3.38524404509426 0.0004672822961977 -2.3612891326806 0.0018846412605175 1.02395491241366 0.167579407027827 reversed False False False False False False False 0 insufficient_or_context_specific +TIMM23 0.0953704102025576 0.572476003813308 0.844973897107944 0.0507283932294082 0.767301384586557 0.91954879692023 -0.475728557944588 0.174136439672617 0.127209198690741 0.693958730912595 -0.348519359253847 0.278783925076614 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WDR25 -0.104358597137071 0.572733174824886 0.844973897107944 -0.153172343985834 0.405872735579619 0.733444811508554 False False False False False False False 0 insufficient_or_context_specific +ERC1 -0.0836144565330321 0.572752869852717 0.844973897107944 -0.0499414710969994 0.734789680487631 0.905134692169922 -0.362001076470572 0.125525121727138 0.0909648381480186 0.676373603042264 -0.271036238322554 0.213114565725459 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITSN2 -0.0816102264925114 0.572841072779525 0.844973897107944 0.110093303579512 0.444465914740556 0.759994423711047 -0.208768002743141 0.548452752179335 -0.373496600659701 0.19169133034125 -0.582264603402843 0.0646769073586702 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF143 -0.108791971823759 0.572866371992675 0.844973897107944 -0.17535859638083 0.359517145062786 0.702743831320045 0.159259990845626 1.0 False False False False False False False 0 insufficient_or_context_specific +PPP1R10 -0.159368756104975 0.573177691727168 0.845059561362593 -0.465557674013126 0.0864181155492397 0.467677448123587 0.444385571803072 1.0 -0.121097111368631 0.675913744273884 -0.187960291933469 0.400838528143754 -0.309057403302099 0.194589274046656 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP21A2 -0.409429748161558 0.573300144339276 0.845059561362593 0.0377837195904405 0.954705662701222 0.987410276805219 False False False False False False False 0 insufficient_or_context_specific +CYHR1 -0.159434192188597 0.573306916537505 0.845059561362593 -0.0584980122319828 0.837663664041962 0.947814056902265 0.5670540402800339 0.0324602206898677 2.0 -0.11140901333203 0.660079599353143 -0.183111172336249 0.356131416037381 -0.294520185668279 0.161898651327278 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDHR3 -0.2199914538783 0.573345804481241 0.845059561362593 -0.268703910041628 0.48926189988928 0.78397740765382 False False False False False False False 0 insufficient_or_context_specific +SLC20A1 -0.247644046916077 0.573390554254248 0.845059561362593 -0.109574931606979 0.805773175314142 0.932788199072101 -0.114511286639389 0.798353298690907 -0.428422265136201 0.193728450586492 -0.542933551775589 0.124091726800373 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GC -0.184399115380186 0.573479564796087 0.845059561362593 -0.113928339270646 0.729950859791757 0.904213522802984 -0.45129073767048 0.527753710138954 0.776076275155982 0.193728450586492 0.324785537485502 0.615187851786999 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GADD45B -0.262258151247101 0.573484727899506 0.845059561362593 -0.477351388709086 0.302578603140245 0.659910120213739 0.703750376633056 0.375953598395324 2.0 0.966886956404108 0.180083542833906 -0.249296417418668 0.674501162967868 0.71759053898544 0.28732002992825 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01695 -0.302362862025768 0.573722957751218 0.845174687866243 -0.7733390692744 0.133736862712528 0.520646680132325 False False False False False False False 0 insufficient_or_context_specific +ZFAT -0.109651459023155 0.573894152664436 0.845230912907886 -0.0347627823772136 0.85907383774537 0.956914759994669 0.11306652868486 0.83030983837404 -0.786055488600703 0.046516211248105 -0.672988959915844 0.113472550685496 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STAMBP 0.107938669173192 0.574030714410623 0.845230912907886 -0.025479206277463 0.89417130787667 0.966191860460739 -0.409167319229048 0.219932855846463 0.0787083284022704 0.797766050252513 -0.330458990826777 0.280590193512036 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDZRN4 -0.22571582154929 0.574144892461767 0.845230912907886 0.101844063407372 0.79881676476977 0.92925379048471 False False False False False False False 0 insufficient_or_context_specific +POC1B-AS1 0.169516953116487 0.574161404373495 0.845230912907886 0.0026466824010476 0.992958542794242 0.998253313161456 True False False False False False False 0 insufficient_or_context_specific +RNF220 -0.159360233184576 0.574760814543113 0.845759537274729 0.0718927460486586 0.794201985781182 0.928063228447907 0.0122187170543934 0.969251940576763 -0.138587942220938 0.525213989981817 -0.126369225166545 0.595139012396859 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MNDA 0.362334161138643 0.574866377395345 0.845796991714054 0.393627068082111 0.545872216735453 0.81552807024429 True False False False False False False 0 insufficient_or_context_specific +NR2F1-AS1 0.130497091196466 0.575223919422079 0.846095496665806 0.159339601709858 0.492246817679081 0.786135516722998 0.2905525778638111 1.0 True False False False False False False 0 insufficient_or_context_specific +AC027097.2 0.120517260029985 0.575319597243206 0.846095496665806 0.104244903250555 0.627415797344348 0.857619884562613 0.0759635409217994 1.0 True False False False False False False 0 insufficient_or_context_specific +EHMT1 -0.0803851846103793 0.575876120147155 0.846574780912512 -0.152607085387542 0.282341070930726 0.643557216512652 -0.154147481764139 0.5445306236067 -0.362211600066098 0.0905458158391764 -0.516359081830237 0.0322061798655977 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ESRRG -0.316635373128065 0.57600964117122 0.846653179936759 0.06097904271261 0.914912541210362 0.974737296680021 False False False False False False False 0 insufficient_or_context_specific +RAD23B 0.091339235716528 0.576130208697141 0.846712519964423 0.214435339701318 0.179945089670372 0.562759923872656 -0.0881632581411384 0.792280419704326 0.268773185320725 0.268202481465296 0.180609927179587 0.49314447246664 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C2 0.176414076953708 0.576482927366747 0.847112978028965 -0.0458153155658917 0.883393636955852 0.96288234502947 0.461329573740394 1.0 -0.741282226058671 0.0180361807086872 0.710966164177552 0.0164331170077147 -0.0303160618811195 0.923755646681849 reversed False False False False False False False 0 insufficient_or_context_specific +FAM13A-AS1 -0.168893572727274 0.577073352216011 0.84766615117312 -0.103434950871259 0.733338579106328 0.904481167627122 False False False False False False False 0 insufficient_or_context_specific +SH3RF1 0.105616011329565 0.577100236278877 0.84766615117312 0.199865729275214 0.286462960786481 0.64687121300967 2.08547842042432 0.0778272736683043 2.0 -0.273272673380273 0.43341360137508 0.148393573638054 0.624970466764503 -0.124879099742219 0.707978911791892 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF460-AS1 0.209950905070287 0.577533429158474 0.848066473582082 -0.101918393047817 0.784169726516187 0.925388445181489 False False False False False False False 0 insufficient_or_context_specific +CUL4A -0.0766132909683344 0.577707829399651 0.848204597803019 -0.0234823691792291 0.866078701771727 0.958391272020028 0.0736362894858219 1.0 -0.249485613551667 0.325017572953707 0.271231844117076 0.214485221261849 0.0217462305654085 0.9355391200702 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF354C 0.193140038403171 0.577863947733809 0.848280284215346 0.0338086254676707 0.919653369741705 0.976045355570903 True False False False False False False 0 insufficient_or_context_specific +PEX26 -0.109227929619426 0.577920068607784 0.848280284215346 -0.112775406471248 0.564765769723144 0.823754286312897 -0.311519840662536 0.402897367721208 -0.136064470110507 0.677585067137296 -0.447584310773042 0.181810651719669 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF385B -0.31867943735445 0.578756089779904 0.849389323866586 -0.855373050362478 0.127186442635853 0.509035049791256 1.14925417618766 1.0 False False False False False False False 0 insufficient_or_context_specific +CNST -0.130823203673672 0.578880440130952 0.849417799592049 -0.277876730719371 0.248551172417303 0.614215233681543 0.0570993970006848 0.272574526360714 2.0 0.305124057260889 0.336589643352118 -0.391314440056046 0.142215759815676 -0.0861903827951575 0.790663895665047 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1RL-AS1 -0.111155133022319 0.579226810605361 0.849417799592049 -0.121288728457087 0.545113934675092 0.81520013063734 False False False False False False False 0 insufficient_or_context_specific +ATAD3B -0.209960722186007 0.579236327792596 0.849417799592049 -0.220181249469083 0.560781689313173 0.822780527970901 0.69717310568307 1.0 False False False False False False False 0 insufficient_or_context_specific +PRKDC -0.0857545658568935 0.579258207715737 0.849417799592049 0.0324890847975576 0.828688198620633 0.942913029532993 0.460216171448775 0.438169986271834 -0.459522562588551 0.311282527259354 0.0006936088602241 0.999330727138224 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM220 -0.137205670935006 0.579408815166881 0.849442230170567 -0.0513027082857311 0.834621780911356 0.946299050994641 -0.530454838130933 0.274973819582601 0.586927179426051 0.146833834022972 0.0564723412951185 0.911503240681756 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC004951.1 -0.182919827681775 0.579493387932673 0.849442230170567 -0.349910879597702 0.268919534310441 0.633055171293118 False False False False False False False 0 insufficient_or_context_specific +RIF1 -0.072943908862565 0.579516232612104 0.849442230170567 0.0463263984238015 0.730419285404 0.904431845923655 0.534879088749997 1.0 0.412022561738297 0.164927451419479 -0.182823452554527 0.465368102283805 0.22919910918377 0.408506477182248 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTPBP2 -0.142218781409772 0.579609795555831 0.849461441071413 -0.321478491547139 0.18995842994044 0.569886897607216 -0.289377200382196 0.435100095127123 -0.688862674742549 0.0425463636841992 -0.978239875124745 0.0138105850453239 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PYROXD2 -0.206854987101127 0.5796967353677 0.84947094129246 -0.228653446552347 0.539929965654485 0.812783927483158 -0.00743221042063 0.986892057607086 -0.438352007976523 0.136640748242516 -0.445784218397154 0.15062366870391 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLD1 0.154067566486749 0.580309647322738 0.850251076385438 -0.351843083316238 0.19922388303274 0.575122356864606 0.24743533545338 0.604145563844111 2.0 -0.415625139508021 0.278705847566216 0.398911919619197 0.211731092750138 -0.0167132198888237 0.968059276593632 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRMT61B -0.106079807756491 0.580554352682672 0.85049158535086 0.0596488045475897 0.743230930765142 0.909273715761109 False False False False False False False 0 insufficient_or_context_specific +NFKBIZ 0.15931796809222 0.580805410692167 0.850627850041685 -0.234701093352193 0.457767339663055 0.767769272781975 -0.61556191391647 0.149394353934129 -0.655869178824861 0.0936329808869639 -1.27143109274133 0.0100642273268408 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLR1D -0.089154421597259 0.580808502647329 0.850627850041685 -0.16389726250539 0.309453992352296 0.662858728430055 0.104494528809008 0.70855008875163 0.0403837689882975 0.869689358314265 0.144878297797305 0.539821382220508 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SS18L1 -0.218717721071603 0.581019785519724 0.850819264288106 -0.295624657102 0.451576386172354 0.764202910889105 0.126589602704947 0.752356269229539 -1.06637809889586 0.0055040065855936 -0.93978849619091 0.0179492054091285 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNAP47 0.193356063618509 0.581598933134187 0.851431161401934 -0.250565523760545 0.449466315874594 0.763796131177204 -0.234889733252893 0.381045978421688 0.334814216843601 0.139844288332455 0.0999244835907086 0.69799924833911 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ENOX1 0.249271207500962 0.581692756010935 0.851450453065777 -0.0356883155051103 0.939525502709161 0.983658266508924 0.880750427629506 1.0 False False False False False False False 0 insufficient_or_context_specific +TMEM219 -0.157109892620101 0.581868161691886 0.851589139332262 0.0267165122758491 0.923936948678101 0.978133591110337 -0.528341905125475 0.151950819487229 0.120298802355193 0.723983381989463 -0.408043102770281 0.228234846064919 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NAXD -0.166589692670638 0.582025999955529 0.851674560608748 -0.370023245017715 0.203964709474307 0.577025563405608 -0.223205635282359 0.410158624426083 0.527560698511861 0.0321429231510805 0.304355063229503 0.202781842185238 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUDT7 0.213503644009505 0.582087860328919 0.851674560608748 0.108594643197368 0.779758879149973 0.92346542300229 -1.7505233924339 0.0039969080665129 1.63439887854206 0.0052482103036662 -0.116124513891841 0.824153930186941 reversed True False False False False False False 0 cross_species_direction_conflict +SFXN3 -0.15084910241527 0.582450810104759 0.851870747436964 0.215119551650902 0.45499166754095 0.766401089007235 0.3800396780993521 1.0 -0.299853110532389 0.342720226913364 -0.318626243859923 0.239629536522155 -0.618479354392312 0.0451444777314344 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIFR-AS1 0.251322024606612 0.582508754936065 0.851870747436964 0.362471849447291 0.429765668033293 0.74852333689201 True False False False False False False 0 insufficient_or_context_specific +CLDN1 -0.165840663564129 0.582577244289592 0.851870747436964 -0.302872561331938 0.311821820165681 0.664337047357073 0.879720386548962 1.0 -0.64872988078352 0.148401695317451 -0.0116528391925193 0.980498143047398 -0.66038271997604 0.115609848279306 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NEK1 0.0905954315653257 0.582614812895411 0.851870747436964 0.208601518000698 0.18855198067919 0.569351952070621 -0.436378642568339 0.133339169609247 -0.0480975083177313 0.867591304581815 -0.48447615088607 0.0814232123159408 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZSCAN5A -0.0705715061557663 0.582767301744103 0.851870747436964 -0.0369397619189569 0.774863199778387 0.921907331897703 False False False False False False False 0 insufficient_or_context_specific +TRPV4 0.317334393395004 0.583019735423972 0.851870747436964 0.222006766512438 0.698575007652879 0.889371148052465 True False False False False False False 0 insufficient_or_context_specific +SLC13A4 -0.236863403646839 0.583115971293896 0.851880230375115 -0.550576841617263 0.162791182083553 0.544298760692042 False False False False False False False 0 insufficient_or_context_specific +LMAN2L 0.122327956873152 0.583203463775488 0.851890173013504 -0.0368557595145108 0.866875666141945 0.958391272020028 0.274210537609123 0.357118365608029 -0.175691654297194 0.475881834857098 0.0985188833119293 0.738535408848397 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IPP -0.157254329784455 0.583289358478429 0.851897779335351 -0.352799844231618 0.20293597389671 0.576835372560841 0.5086642030455529 1.0 -0.154984152250667 0.717344022405823 -0.0742309162028547 0.831040170492243 -0.229215068453521 0.523432126016667 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIG3 -0.163461048912849 0.583466652974016 0.851902140560306 -0.495910131288393 0.0871843954531286 0.468303538747472 0.224111487230658 0.471119257261521 -0.358920653241468 0.160411469873509 -0.13480916601081 0.644387650688514 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPI -0.150131600985775 0.583565648636545 0.851902140560306 -0.192595937704004 0.47977595523855 0.780162456875056 0.455249736867581 1.0 False False False False False False False 0 insufficient_or_context_specific +RGPD8 -0.219946736751817 0.583665608163744 0.851902140560306 -0.0894804519343734 0.827200634079775 0.942259214105446 False False False False False False False 0 insufficient_or_context_specific +PHLDB1 0.14381277831613 0.583695783748177 0.851902140560306 0.0621009682980666 0.812361345235435 0.934100531800885 0.368850152788284 0.226605338581325 0.086720735407216 3.0 -0.176268286954546 0.653396314246701 -0.245715534603211 0.429918832355209 -0.421983821557757 0.195289377778318 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KRBOX4 0.0940955981897942 0.583886440146967 0.852062617148815 0.024845157693724 0.885914248318352 0.963332560016303 True False False False False False False 0 insufficient_or_context_specific +SNED1 0.200798577453016 0.584016254030393 0.852134274468338 -0.0186525032489298 0.959800102375533 0.988617762369409 0.180642627714417 0.626977933297638 -0.0014213553044482 0.996782557292892 0.179221272409969 0.580771576468494 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FCF1 -0.153150029998116 0.584191880300577 0.852152475198783 0.0066530014857575 0.980959440599259 0.994237282696264 -0.135815472585865 0.701769001297478 0.173962263687772 0.519448273419556 0.0381467911019072 0.911323989093389 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KMT5B -0.0717965075870607 0.584257206098508 0.852152475198783 -0.0444018722588555 0.73655574075801 0.906041653375634 0.257608554969321 1.0 0.0378732031672969 0.901577906130256 -0.30227512286423 0.149439965149069 -0.264401919696933 0.229137443039796 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FST 0.339275833300598 0.584311871329772 0.852152475198783 0.462220179956805 0.460575729162841 0.768745132096508 1.1098421772398 1.0 -0.201495075710604 0.793326148916304 -0.0608359185514954 0.922724260143162 -0.262330994262099 0.683169836203475 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CMTR1 0.145971234658916 0.584351574203371 0.852152475198783 0.0651190869120107 0.807634661783762 0.932788199072101 -0.122108828705914 0.682055542384383 -0.190364569607373 0.412147343953121 -0.312473398313287 0.201833682859162 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GSR -0.155467530105984 0.584776141864679 0.852453282871778 -0.286763464671531 0.306543236072378 0.661696690217148 -0.0208875452272532 0.954530635502806 0.384558789132143 0.118991130474109 0.36367124390489 0.159566817186807 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BMP4 -0.331976700547012 0.584866028234257 0.852453282871778 -0.364906460409047 0.549065931636628 0.816365047001981 -0.340254138283095 0.328151730960753 0.468213354983531 0.118253968709253 0.127959216700436 0.70550760479556 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC35C1 -0.279454386574721 0.585047401993882 0.852453282871778 0.433954135489611 0.409598758315897 0.734946310126928 -0.298695262650643 0.444514357722159 0.485358354289389 0.125236535876845 0.186663091638746 0.596220682981818 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DIO3OS 0.208098940098147 0.585221515780411 0.852479134052094 -0.0754921462484233 0.838286137270755 0.9478289694297 0.3859797663781521 0.258150854627088 2.0 False False False False False False False 0 insufficient_or_context_specific +TAGLN2 -0.199353954031244 0.585852985540069 0.853045900059585 0.207147648664188 0.582256592618078 0.833494998054781 0.705112391224727 0.0857565300712182 -0.505100319077197 0.16216918815922 0.20001207214753 0.613631873014617 reversed False False False False False False False 0 insufficient_or_context_specific +CARD8 -0.0930548977151306 0.58604797599568 0.853212152587202 -0.204241537264893 0.226529763866646 0.598909102217928 False False False False False False False 0 insufficient_or_context_specific +AP002495.2 0.0986261003293927 0.586512971086673 0.853300805943653 0.0614527489977712 0.733135153940635 0.904481167627122 True False False False False False False 0 insufficient_or_context_specific +ZNF84 0.094287373914176 0.586678688288671 0.853424302969384 0.308898646464366 0.0708693494460594 0.443801226075734 True False False False False False False 0 insufficient_or_context_specific +ELMOD3 -0.0951338860678601 0.586923222905422 0.85352973669832 -0.023422998874062 0.892950196711686 0.965661185556767 -0.403207507768746 0.303350793900669 0.0759838213246421 0.836543207084056 -0.327223686444104 0.358679774644169 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM208A 0.0982895621205769 0.586966457468091 0.85352973669832 0.199381505691607 0.263854016699252 0.626379950271573 True False False False False False False 0 insufficient_or_context_specific +CLTA -0.0807331260816767 0.586993693707757 0.85352973669832 -0.144016572588884 0.326552990251325 0.675949642085426 -0.23113748804617 0.495068568403865 0.107609813904023 0.718192135559082 -0.123527674142147 0.697657101580954 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFRKB -0.129216915722407 0.587101268915327 0.853568603305979 0.0593698774319621 0.802057176604933 0.930781165449847 0.0305462657368995 0.947823803226719 -0.201286257289183 0.50613225386717 -0.170739991552283 0.62303817060341 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DTX1 0.255642492237176 0.587236208058595 0.853647237323785 0.460155833934653 0.329063708101498 0.677903342465487 0.039303756993992 1.0 True False False False False False False 0 insufficient_or_context_specific +AF165147.1 -0.273563442709357 0.58794427987514 0.854508314998042 -0.625073718187521 0.204597329008961 0.577886195740131 False False False False False False False 0 insufficient_or_context_specific +KLHDC2 -0.108873315115785 0.58799042512415 0.854508314998042 -0.231708646481146 0.228808245989522 0.600424738880655 0.0536204821336964 1.0 0.144184450350047 0.573619496442142 -0.190142336274313 0.355006609806306 -0.0459578859242652 0.854299243271885 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF720 0.0820522191756659 0.588127133104258 0.854510413985893 0.166889844829378 0.271670668954895 0.635704548498622 True False False False False False False 0 insufficient_or_context_specific +MIR193BHG -0.313946049800428 0.588165760949541 0.854510413985893 -0.317363237483244 0.584413803608774 0.83427397074951 0.0365569380101789 1.0 False False False False False False False 0 insufficient_or_context_specific +PTTG1IP -0.118065044680344 0.588450869420571 0.854510413985893 -0.053071397722954 0.810709866006559 0.933438195229734 0.291246146980097 1.0 -0.324108898256623 0.293179276637488 0.492801765842933 0.0765949471375164 0.168692867586311 0.562508519545956 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPT2 -0.386633392352942 0.588510588540269 0.854510413985893 -0.439354571340067 0.537523453975022 0.812087893451657 -0.0510692894127915 0.91811179760286 0.35050976452382 0.297954127258904 0.299440475111029 0.398444622417425 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AJ009632.2 0.647493469496288 0.588599686701016 0.854510413985893 0.57561673846375 0.629412467026682 0.858587581812126 True False False False False False False 0 insufficient_or_context_specific +PDCD2 0.128583341484702 0.5886172477156 0.854510413985893 0.348744410209355 0.124772910222109 0.507064043928032 -0.0410714939500985 0.935285427653295 0.130436926220395 0.701257766351356 0.0893654322702966 0.822691819724128 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KLF11 -0.155812927171725 0.588675406329131 0.854510413985893 -0.441523428047756 0.106824169898049 0.483261130274234 0.130500581040455 0.820525357512389 0.133757393644498 0.749692334394936 0.264257974684953 0.556376616169109 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF169 0.0971168781325537 0.588840803590701 0.854510413985893 0.087332836801402 0.626200278570169 0.856624485564009 0.435751797839368 1.0 -0.344718046560275 0.237435791621159 0.0383016649792651 0.898538419616309 -0.30641638158101 0.252754441769745 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CAMK2N1 -0.132459927311403 0.588923062393867 0.854510413985893 -0.196660357313753 0.421787996115527 0.743817882576872 0.3303087031534099 1.0 -0.465532296717269 0.16483844948833 0.292958238160018 0.322030768312832 -0.172574058557251 0.592389303184399 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLIC2 0.208752150241107 0.589006288418788 0.854510413985893 0.126006519687555 0.745105623848852 0.909500945159707 True False False False False False False 0 insufficient_or_context_specific +FRMD3 0.203281152950687 0.589070608497704 0.854510413985893 0.288643269809327 0.442852022965516 0.758907914051277 1.61422352533805 1.0 True False False False False False False 0 insufficient_or_context_specific +ZFP36 0.187922291777001 0.589879515788044 0.854873832527718 -0.101204023147376 0.777112708216822 0.922929913000972 0.393824217374475 1.0 -1.36994511777668 0.0179103257759243 0.82933314823482 0.090486390993179 -0.540611969541864 0.271919348465547 reversed False False False False False False False 0 insufficient_or_context_specific +IGF1 0.256451621777646 0.589991592437298 0.854873832527718 0.0336505527120057 0.943417632416502 0.984366565940656 -0.617321907196345 0.206602155412019 0.750240435194745 0.0912991429418926 0.132918527998401 0.790054144334233 partial_or_other True False False False False False False 0 cross_species_direction_conflict +UNC5C 0.161009042721734 0.59002326365121 0.854873832527718 0.311867746401284 0.294980934689103 0.652548722847306 0.7204184885141629 1.0 True False False False False False False 0 insufficient_or_context_specific +CCDC198 -0.326824595348121 0.590385312943926 0.855163689677867 -0.164936417315072 0.788547887174237 0.926576536501901 False False False False False False False 0 insufficient_or_context_specific +SIRT2 0.100131403016908 0.590690701397274 0.855486532309081 -0.0504537134281167 0.793083748211707 0.927620871373898 -0.0376778242349574 0.908381786429681 0.171977125267327 0.433752763161774 0.13429930103237 0.578596883959479 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMIM15-AS1 0.223206249308085 0.590770250716567 0.855486532309081 -0.108239889548894 0.79270182192114 0.927620871373898 False False False False False False False 0 insufficient_or_context_specific +ZNF449 0.188697170501683 0.591182611268183 0.855966265739095 0.492248747443955 0.153047872857425 0.536485533522497 True False False False False False False 0 insufficient_or_context_specific +TEC -0.197759773986636 0.591493434438145 0.856102909714223 -0.118760135234284 0.749312821996182 0.910804141680369 -0.961328485456688 0.0750138302723842 0.310444627005559 0.513669065240725 -0.650883858451129 0.181327509351142 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC068875.1 -0.25977779857205 0.59152024307305 0.856102909714223 -0.219060165320577 0.651043247340851 0.86994747754025 False False False False False False False 0 insufficient_or_context_specific +CRKL -0.121422362220776 0.5919004369612 0.856535747455641 0.21267978508698 0.35631838059794 0.699648402892514 0.661500679847173 0.6075732810134069 2.0 False False False False False False False 0 insufficient_or_context_specific +CLHC1 -0.207761594490119 0.592100700765587 0.856590737007819 -0.333305769564239 0.382322084133119 0.718248498981756 False False False False False False False 0 insufficient_or_context_specific +FRY 0.163222670188357 0.592283232673075 0.856737412051285 0.369077415338146 0.207860218191946 0.580700057930969 0.118592983299647 1.88428876563291 0.00763294282050275 3.0 -0.203265635575213 0.799388400156493 -0.282117013071942 0.626275958842421 -0.485382648647155 0.44536366430217 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COX10 0.119739635248147 0.592551387995939 0.85683915270093 0.225484830681928 0.312110893502725 0.664502281428064 -0.249871840818625 0.491900310997039 -0.0191418884790828 0.954649369537061 -0.269013729297708 0.398148926554917 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SIRT3 -0.155868090689017 0.592597034762473 0.85683915270093 -0.192540251395484 0.508297192369676 0.795052112153932 0.463975308739848 1.0 -0.689566660757001 0.0519992319569476 0.307224578124961 0.31319589434607 -0.382342082632039 0.229407973616812 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYTH2 -0.145985334373977 0.592840598787371 0.857052681282608 -0.222428690799055 0.416931557382635 0.738336696217018 0.3576108045708811 0.7470531148556641 2.0 -0.077082060018221 0.804826425997151 -0.276615980208552 0.220878659684542 -0.353698040226774 0.142523178368053 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKRD13D -0.113953070742027 0.592907064225059 0.857052681282608 -0.0910450600921169 0.668664282543905 0.875941737812246 0.174960082240999 0.831215706531321 -1.15763611003765 0.0608040167517772 -0.982676027796647 0.153749035214437 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HDHD5 0.148781511617062 0.59306403921787 0.857162234916121 0.176144811507887 0.528213367199245 0.805790598307994 -0.129628225429334 0.642969748219804 -0.26461270451565 0.228979343872745 -0.394240929944985 0.100356735176533 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MSL2 -0.0972083292124114 0.593240168890343 0.857231399605192 -0.138786135874467 0.438254080580211 0.75507287577772 0.426555668642874 1.0 0.201368313957024 0.455080336983835 -0.104963540189609 0.649998300148942 0.0964047737674152 0.707978911791892 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLR3A 0.14058347622488 0.593543503713203 0.857464679884317 -0.0840664736791324 0.750445550825186 0.911659131290248 -0.172399260925876 0.605341654253625 -0.502660346778833 0.0703518890503919 -0.675059607704708 0.0327661453831597 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANAPC5 -0.064148691426959 0.593799453462605 0.857520808324195 -0.0756586395451246 0.528208988150751 0.805790598307994 -0.0767170494522486 0.846388159848326 0.182193055425155 0.509274625041226 0.105476005972906 0.739914349687052 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF226 -0.139311578629915 0.594126807867933 0.857762344697794 -0.142469482914023 0.58597463139421 0.83502769041167 False False False False False False False 0 insufficient_or_context_specific +PDAP1 -0.123826370187263 0.594200204496004 0.857762344697794 -0.123386943371891 0.595343061061727 0.840662302887484 0.7255097789801229 1.0 -0.158587438501252 0.584723481841199 -0.0179941186940252 0.947549942966529 -0.176581557195277 0.479960474456969 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRP1 -0.090381072938764 0.594210436552346 0.857762344697794 -0.0929596272723753 0.582768902568939 0.833609818902975 -0.0219439677206362 0.959842389191232 0.110134102135737 0.729958610789791 0.088190134415101 0.800418814149132 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INAFM1 0.166846969616101 0.594519460102597 0.858091108648423 0.126858659723736 0.686793274409255 0.884207658069991 0.472038805071703 1.0 True False False False False False False 0 insufficient_or_context_specific +ADAMTS15 -0.273680629317297 0.594946954876834 0.858279787958938 -0.856298705155036 0.0651817930926692 0.435515719106489 0.4816165210768421 1.0 0.80993108041942 0.122986494999844 -0.307791307858977 0.480162332709965 0.502139772560443 0.3050066565493 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01485 0.499183004615192 0.594972478872025 0.858279787958938 0.562495865952827 0.554653450225279 0.819814244898102 0.441600044995655 1.0 True False False False False False False 0 insufficient_or_context_specific +ATP5MC2 -0.1102397217481 0.595041866934485 0.858279787958938 -0.0841696214950695 0.685924027711025 0.883592781626934 False False False False False False False 0 insufficient_or_context_specific +AC040934.1 0.148739765334985 0.59524685366496 0.858279787958938 0.427247621634068 0.136395744479768 0.523136620282319 0.0378889505791782 1.0 True False False False False False False 0 insufficient_or_context_specific +ISOC1 -0.181548901185032 0.595327385345899 0.858279787958938 0.13924521722226 0.694176211699162 0.887432585446834 -0.237048481001537 0.56634874805227 0.762411611403042 0.0297827090668634 0.525363130401504 0.13030477652057 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALDH7A1 0.155180332848 0.595342062594192 0.858279787958938 0.0094303197675008 0.97426648187205 0.992472605004756 0.138600591720181 1.0 -0.463635052474541 0.30750071605341 1.05263005975225 0.019084952047439 0.588995007277713 0.15517412676519 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC020928.1 0.151887030841891 0.59550620153199 0.858279787958938 -0.0977724614758902 0.732054907715324 0.904431845923655 False False False False False False False 0 insufficient_or_context_specific +UTP11 -0.235203190599959 0.595720461701105 0.858279787958938 -0.0377156231926629 0.934717451402586 0.981436002157239 0.599299063822228 1.0 0.0089059994091932 0.981097781386872 -0.140117718885267 0.58113785578188 -0.131211719476074 0.640460922496986 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCERG1 -0.0958956755336374 0.595751676463271 0.858279787958938 -0.0819066569130842 0.650860218580442 0.869901306439436 0.22820863182178 0.516395986649668 -0.554973277779623 0.0616215833826196 -0.326764645957843 0.292358463366911 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUDC -0.123981359645008 0.595904114430703 0.858279787958938 -0.0804938684809341 0.731787653003864 0.904431845923655 -0.400860961802991 0.179457988630067 0.105803460340065 0.702664448406005 -0.295057501462926 0.283682080171443 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABHD2 -0.185728869240383 0.59600558838319 0.858279787958938 -0.187421958029124 0.592905444515209 0.838948945383755 0.591189777584031 1.0 0.996984852392558 0.0028747876088535 -0.64101578397413 0.0178777263721637 0.355969068418427 0.170251582770632 reversed False False False False False False False 0 insufficient_or_context_specific +NPHP4 0.125378671407312 0.59606268828988 0.858279787958938 0.406781120634517 0.0747649350723815 0.452862231765951 0.437079715358658 1.0 -0.237604509549588 0.80772018428236 -0.249949173837734 0.723983381989463 -0.487553683387323 0.536747570298357 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM263 0.110623316505842 0.59608017963942 0.858279787958938 -0.132411536859653 0.543119809841849 0.814409736161091 0.265903329711191 0.370232091268869 -0.685701044276381 0.0175250560999937 -0.419797714565189 0.125149375302564 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB11FIP1 0.145762853852903 0.596306090385404 0.85843553233977 0.0654123587578104 0.812452032171063 0.934103076953292 -1.50982283329423 0.012292899394134 0.712858877332933 0.149717547510882 -0.7969639559613 0.105919699383799 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ALB 0.219544173711468 0.596408891033389 0.85843553233977 0.54685798058602 0.190476929444805 0.569976343069084 -0.297567632023272 0.771467532726606 0.657122185549433 0.398581584183184 0.359554553526161 0.677750418563714 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CLEC16A -0.074216747437326 0.596465529953074 0.85843553233977 -0.108216480387155 0.441630036911321 0.758060094004529 0.017867671969173 0.969251940576763 -0.0287234080951535 0.934370385494933 -0.0108557361259805 0.979513759000443 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRUB1 -0.164858314768666 0.596764821679031 0.85863218687479 -0.0082077824416574 0.978873244422905 0.993800106187985 -0.294351802310507 0.42557524288983 -0.383025619900999 0.218725266182396 -0.677377422211507 0.054364904122675 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KTN1 0.0762877076448479 0.596968012541291 0.858790465315911 0.162765048110248 0.247140537320747 0.612557966068705 -0.0037126672180463 0.992788933773383 -0.459946533413658 0.0814254189719889 -0.463659200631704 0.0931698863344416 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GOLT1A -0.292385808136403 0.597037508564007 0.858790465315911 -0.51669295831285 0.341895135177245 0.689130402583821 False False False False False False False 0 insufficient_or_context_specific +ZNF554 -0.242366827423611 0.59763748854479 0.859160820957922 -0.478767669013791 0.278274786407049 0.64163031117834 False False False False False False False 0 insufficient_or_context_specific +RALGAPA2 -0.128496440141442 0.597811016573338 0.859160820957922 -0.116140392657586 0.633550889692654 0.861544344844802 -0.158272370256267 0.607621642653022 -0.0794106787101279 0.763276683201078 -0.237683048966395 0.362604637096813 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYH11 0.295473083690451 0.597821732034812 0.859160820957922 -0.195690194784934 0.732668602949885 0.904431845923655 1.66251036845974 0.0701101448003759 2.0 1.63905177233576 0.0117937483379435 -0.941741360946294 0.0660983749716994 0.697310411389463 0.211742422288133 reversed False False False False False False False 0 insufficient_or_context_specific +GTF2E2 -0.0721480372342062 0.59784452121081 0.859160820957922 -0.0394647122272048 0.77515934146831 0.922042522642161 0.225732536479303 0.382411820664661 -0.34418599447126 0.114909589421275 -0.118453457991957 0.633798386476644 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBR3 0.079272864541554 0.597864609924025 0.859160820957922 0.14538842532679 0.325370224252946 0.674724889947951 -0.11260640891334 0.698435327991522 0.142013991950238 0.534688835450744 0.0294075830368989 0.917064991174959 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM122B -0.135099137989469 0.59830692360733 0.85951812633815 0.155488295905683 0.5142742233669 0.798491683514042 -0.158277727614721 0.773942764414124 0.0793484769153794 0.854557850386868 -0.0789292506993414 0.874767323208828 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM234 -0.155231539123881 0.598309082239521 0.85951812633815 -0.0486587618167366 0.869896903824198 0.958502690861149 -0.010945026910607 0.971220331487005 0.0165006881923425 0.946247207753935 0.0055556612817355 0.984758817752833 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DCHS1 -0.254803087599885 0.598397408143983 0.85951812633815 -0.450636792765759 0.348791814279984 0.694288655897113 0.279865634862443 1.0 0.542830289364406 0.137147203995205 -0.576758001984631 0.0654920779855076 -0.0339277126202248 0.933602644063331 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC068446.2 0.224852186002212 0.598438884894084 0.85951812633815 0.173271955196434 0.683892980421289 0.882766419515653 True False False False False False False 0 insufficient_or_context_specific +SLC17A1 0.41194098988611 0.598656437912657 0.859592963924676 -0.117062662589576 0.878582334323199 0.961432567887278 0.200262822691712 0.769502368037078 -0.442999430710395 0.353143752038602 -0.242736608018683 0.68628311999987 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERP44 0.0933655897456403 0.598879748100079 0.859683532350868 0.195647894495622 0.254753895706487 0.619879203544451 -0.131683563719822 0.701284020990754 0.538232495075808 0.0497965297487977 0.406548931355986 0.14527488436389 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC008892.1 0.22409404597682 0.599284569361339 0.860015004516037 0.136487224012677 0.745847424674655 0.909628867935198 True False False False False False False 0 insufficient_or_context_specific +RPS9 0.105157320395156 0.599404565803351 0.860015004516037 0.162953333571184 0.41087691459039 0.735260756651752 0.0270579484945906 1.0 True False False False False False False 0 insufficient_or_context_specific +AP000317.1 -0.188827004447767 0.59945500774988 0.860015004516037 -0.337493583237897 0.341568297115956 0.689048585850067 False False False False False False False 0 insufficient_or_context_specific +PSMD12 -0.112100497179393 0.599801227781613 0.860041305122755 -0.226609406336026 0.274134114989033 0.637623822254105 0.308009851494049 1.0 -0.163948999411207 0.56877374863889 0.433305322722089 0.0688023906896068 0.269356323310882 0.266604302486844 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RHBDF1 0.164350927806679 0.600052043072424 0.860041305122755 -0.0128013199283415 0.967699089109846 0.991065707083724 0.201778290485935 0.534060441346628 -0.505369513322704 0.066994051612373 -0.303591222836768 0.280607001482396 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHTF8 -0.137253018645358 0.60007983607072 0.860041305122755 -0.433972846798887 0.0736783771988742 0.45226529445681 False False False False False False False 0 insufficient_or_context_specific +LINC00665 -0.19914124675418 0.600136303246251 0.860041305122755 -0.305508409260725 0.417301141035829 0.738619521719411 False False False False False False False 0 insufficient_or_context_specific +ZNF528 -0.145052444904827 0.600169729462866 0.860041305122755 -0.045002661020898 0.869619095753326 0.958502690861149 False False False False False False False 0 insufficient_or_context_specific +GOLGA4 0.0806498618939726 0.600259169966571 0.860041305122755 0.142930239919819 0.351075201070295 0.695703312194568 -0.159760599077216 0.524167325961423 -0.311706072497382 0.135981280299817 -0.471466671574598 0.0425665157431516 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FYCO1 0.112730072837838 0.600269404948814 0.860041305122755 0.149788191925595 0.487230986661199 0.782147598778917 0.971971467388414 1.0 -0.111558091461794 0.664875881263502 0.0361148926012663 0.87416113669257 -0.0754431988605276 0.744758898214939 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RNF128 -0.244192462788123 0.600744049723663 0.860604569468444 -0.0410232519668649 0.932738168922372 0.981056942367245 -0.0968815593600626 0.893686961351973 0.920184226254687 0.0657913189709161 0.823302666894625 0.114681685105138 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLA2G4A 0.204664529209866 0.600888990713614 0.860695423138562 0.076879580689247 0.845366240299701 0.951431272261405 -0.560923495962899 0.43244138495147 -0.108016914676775 0.873221488113125 -0.668940410639675 0.293560681619979 partial_or_other True False False False False False False 0 cross_species_direction_conflict +OSMR -0.0863441212688577 0.601112048501683 0.860898129148232 0.0824759761009753 0.606307273835863 0.846931578987574 0.811383971505304 0.122682797342233 -0.553010510599831 0.221404588002435 0.258373460905473 0.613116312494816 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXL18 -0.140839293099416 0.601283321513087 0.860963793661404 -0.285813736286878 0.255007693174887 0.619933507838006 0.514255379232837 0.216666259562647 -0.857190018627802 0.0258302488325242 -0.342934639394965 0.403315594089091 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GOLPH3 -0.0752299074692036 0.601320990193142 0.860963793661404 -0.101658707525483 0.480849367883692 0.780346070738476 0.426756599355552 1.0 -0.31483420946339 0.202066321336793 0.0444116960652156 0.856631457818978 -0.270422513398174 0.233594682387401 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC36A4 0.114933055565483 0.602112135139028 0.86161256690962 0.0915106133669159 0.678111854388778 0.879978485574818 -0.0451524220217048 0.932202662560267 -0.0449572572395597 0.910476463165681 -0.0901096792612644 0.830709877018395 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NDEL1 -0.141562609401337 0.602136395009938 0.86161256690962 -0.245306662170851 0.367568926943399 0.708317354196916 -0.0411918325839881 0.915716967794204 -0.366593956883372 0.163689457890572 -0.40778578946736 0.143799657988888 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CEP135 0.129834671516951 0.602182149197394 0.86161256690962 0.282409310287564 0.243965055281316 0.610315684654444 0.272677586334123 1.0 -0.303768711621764 0.530443864631137 0.190749109223727 0.625843978753854 -0.113019602398037 0.805998221009205 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZBTB41 0.125559418479768 0.602379823876513 0.861690108458547 0.143889218878395 0.550431855058108 0.817186218568941 -0.086005271433414 0.848469497263159 0.0784171706225671 0.812843267062957 -0.0075881008108469 0.985491115834134 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NFX1 -0.0755791655487735 0.602399572886203 0.861690108458547 0.0129107723805517 0.928899303824841 0.979458588812811 0.102924347097548 0.0755058370708039 2.0 0.101649386390387 0.709601928609559 -0.547710948205097 0.0209940831153454 -0.446061561814711 0.0600318905030974 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPN1 -0.130332776374647 0.602935954225768 0.862092613285174 -0.2766520419834 0.270193943212806 0.634531964851516 0.254119426683515 0.60511776798767 2.0 -0.302465818048588 0.363446164228061 0.093637930716733 0.760575555362796 -0.208827887331855 0.49488130255551 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RFT1 -0.166590733097367 0.603007572372704 0.862092613285174 -0.0842043149879712 0.795009464549053 0.928199704380062 0.137202037646371 0.763586447676226 0.0877287025201465 0.801412006928305 0.224930740166518 0.544338946509633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RCC1L -0.0996562173887615 0.60314421930369 0.862171224940206 -0.152595403382057 0.410300597640275 0.735152897523944 1.65631518993985 1.38124998777326 2.0 -0.288059334592324 0.451396234143685 -0.054319096597785 0.880071008863012 -0.342378431190109 0.310667909097746 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RCBTB1 -0.124534455781975 0.603595409695399 0.862699382098825 0.168891599085372 0.466314415188776 0.771256747133237 -0.231889139573958 0.586880747018774 0.249892871524759 0.464777254356878 0.0180037319508013 0.967219239371663 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STK36 -0.161641032791072 0.603950491042023 0.862868157695827 -0.293261219703901 0.35176671012231 0.696018164443657 0.604377768991855 0.323460921427738 -0.633546507821132 0.186680018338252 -0.0291687388292771 0.967436375534897 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GLI4 -0.175675411802398 0.604010351012813 0.862868157695827 -0.111886068560102 0.744103195348695 0.909384383019378 0.5207643360336 1.0 False False False False False False False 0 insufficient_or_context_specific +C3ORF67 -0.194087366079614 0.604040400978392 0.862868157695827 -0.0389416949962207 0.918484253049139 0.975930957742715 False False False False False False False 0 insufficient_or_context_specific +ERLIN1 0.137897917731063 0.604246346576995 0.862924906369035 0.194912585184749 0.462995535733742 0.769320698854699 0.302251800902169 1.0 -0.475659922962357 0.188039388527391 0.0526526383947018 0.884770778437157 -0.423007284567655 0.203314538443706 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RBM33 0.0675640245323264 0.604325322759296 0.862924906369035 0.0501721175676427 0.699190997371181 0.889654761580003 0.290132447230101 1.0 -0.107925767985525 0.708091028975785 -0.0968254982255883 0.681430298291881 -0.204751266211113 0.386490524414218 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TTLL1 -0.194620119356083 0.604701618796804 0.863345461968446 -0.226343822735859 0.546374277187384 0.81552807024429 1.5395477997999 1.0 -0.260607169023345 0.637267773307338 0.538069158863323 0.170723484444329 0.277461989839978 0.542350095476212 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIK3 -0.117665271564977 0.605027706805573 0.863570915824295 -0.092747906573305 0.681922846586647 0.881672962804534 0.568327662243056 0.341683384678938 2.0 -0.0930425002603384 0.770888086920961 0.219467970103189 0.35012310749604 0.12642546984285 0.633239942743346 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VSIR -0.21853921405807 0.605034423266206 0.863570915824295 -0.452154243285871 0.278763765944633 0.642056684302669 -0.652236354533967 0.28816519371029 -0.256804994544201 0.645943661905057 -0.909041349078168 0.116263946908336 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BAAT -0.347599624266545 0.605185696818674 0.863570915824295 -0.491933443389443 0.463021977541346 0.769320698854699 -1.32416029988384 0.07906117028157 1.57952209825918 0.0209986397653746 0.255361798375336 0.698007266941827 reversed False False False False False False False 0 insufficient_or_context_specific +GTF3C3 -0.0987140497674239 0.605301021862889 0.863570915824295 -0.0446015668055878 0.817582097359306 0.936635393220438 -0.0003676052889325 0.99931014544354 0.153852725026341 0.631046471138302 0.153485119737409 0.677681698018855 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTTN -0.0896409205698291 0.605326512478955 0.863570915824295 -0.0117317895805512 0.945712269722198 0.985432868134933 0.4203838816355421 0.0744424193741318 2.0 0.192217605690774 0.492290195399941 -0.566355713969768 0.0274749935904836 -0.374138108278994 0.131333162185347 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRH1 -0.144141873852889 0.605530935829662 0.863711918466573 -0.0508414139161393 0.858114519441703 0.956914759994669 False False False False False False False 0 insufficient_or_context_specific +C1ORF123 -0.145986215256318 0.605723423775339 0.863734983918032 0.0171679687354173 0.950667307184559 0.986917609553614 False False False False False False False 0 insufficient_or_context_specific +ARHGAP28 0.283866185496053 0.605734424464477 0.863734983918032 0.246445607696766 0.655341122935693 0.871339568994744 0.3658481756914221 1.0 -0.545525916036187 0.0982306692466134 0.200408248332392 0.487229895375958 -0.345117667703795 0.252500898993632 partial_or_other True False False False False False False 0 cross_species_direction_conflict +VEGFD -0.217633273316659 0.605792532289546 0.863734983918032 0.0086970626647043 0.983398500364311 0.99451887511202 2.17038798711873 0.0009201172757891 -1.61100826157692 0.0026194840581572 0.559379725541806 0.2654898395993 reversed False False False False False False False 0 insufficient_or_context_specific +RELL1 0.143678550087764 0.60607041434748 0.863859545319488 0.0792985573159811 0.775106192635751 0.922042522642161 0.384192300442022 1.0 -0.082508899941102 0.811836815903341 -0.082431540892853 0.754350383199834 -0.164940440833955 0.545429013479587 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CASP2 -0.111717767809441 0.606138552226401 0.863859545319488 -0.238926662441353 0.26516470364154 0.628085922351979 -0.213670132839436 0.619984737763936 0.151758562254496 0.652172782088925 -0.0619115705849394 0.882160573064927 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RHBDD3 0.170604190547191 0.606279774625338 0.863859545319488 0.0335703389013022 0.918057420322612 0.975930957742715 -0.272093780590953 0.476813796883827 -0.427539055226197 0.182104458786439 -0.69963283581715 0.0525662646265311 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BDNF -0.336750860078374 0.606288997046543 0.863859545319488 -0.333106173885131 0.610843463891793 0.848390744855719 0.947636445520899 1.0 1.40449676639865 0.0755124187971415 -0.216713866638275 0.689154905629435 1.18778289976037 0.114761704055101 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RDH13 -0.154504378799157 0.606730803483923 0.864255777547661 -0.241727826913189 0.416264403261048 0.737650145960078 0.476158443092208 1.0 -0.224373799307759 0.532893532101164 -0.499257528045473 0.0964123159798481 -0.723631327353232 0.0358015759997464 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PITPNC1 -0.179007778373462 0.60691198583443 0.864397240852544 -0.281484571185889 0.413646510567694 0.736347978178 0.149405583012754 0.0351680742282677 2.0 -0.0403866342846076 0.8890677464436 -0.410464214847447 0.0528173138502621 -0.450850849132055 0.048396456422247 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1QTNF3-AMACR -0.101358676138518 0.607295610125246 0.864826955988987 0.0230406867589768 0.907898385580772 0.971381349307032 False False False False False False False 0 insufficient_or_context_specific +FBXW11 0.0672736867328929 0.607395744701997 0.864852902570963 0.219322963952698 0.0879982586882753 0.468622105620855 0.6407495980705611 1.0 -0.0473406586097681 0.895560263778032 0.0677588377794114 0.798545372308589 0.0204181791696433 0.946465279459344 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PFKL -0.172812352824742 0.607727768075551 0.864960526893789 -0.178657230845204 0.595538967305497 0.840747006103054 -0.192970634557609 0.529657804544518 0.0416702947800228 0.884025630837274 -0.151300339777586 0.582384507417856 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NKAPD1 0.149053330305219 0.607848135433019 0.864960526893789 0.345212313999644 0.226330408005778 0.598896352813286 -0.282140384448197 0.34475600395944 -0.36809820602809 0.155577495773613 -0.650238590476287 0.0311436864985105 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM200B 0.145067926477363 0.607882610279483 0.864960526893789 0.334967318538025 0.224180424812234 0.59604556161359 0.0346653927280932 1.0 True False False False False False False 0 insufficient_or_context_specific +EBPL -0.133934868832316 0.608010323221836 0.864960526893789 -0.377456061787309 0.132402834412578 0.518682589655195 -0.209891671420701 0.660094015161262 0.481374255606368 0.19735172752457 0.271482584185666 0.497028150347861 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NCAM1 -0.300321962179901 0.608140295413838 0.864960526893789 -0.27092587473176 0.644351454165761 0.866251949351307 1.89419778947114 0.0095142747517041 -1.25860273190974 0.0318854906794714 0.635595057561403 0.308752545689837 reversed False False False False False False False 0 insufficient_or_context_specific +CSRNP2 -0.133254724533357 0.60819565816287 0.864960526893789 -0.233758457999608 0.365170016925913 0.706387878106228 0.5665554225410611 1.0 0.803168743037672 0.133634053967728 -1.11466707017813 0.024450824935175 -0.311498327140462 0.573324965024611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GNS -0.0944310251468469 0.608222385163189 0.864960526893789 0.068872312440687 0.704212934714648 0.892245309578453 0.0425335429475291 0.901577906130256 0.335677497945584 0.155973798885351 0.378211040893113 0.128961433074132 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM19A1 0.159886704531755 0.608377417017935 0.864960526893789 0.104953604052833 0.738592354970653 0.907558041400239 True False False False False False False 0 insufficient_or_context_specific +AC003006.1 -0.124543020630571 0.608641370663485 0.864960526893789 -0.0909577237698369 0.710240378228928 0.894621559692319 False False False False False False False 0 insufficient_or_context_specific +APP -0.146642775044909 0.608750085235253 0.864960526893789 0.0815068909546241 0.773921828817791 0.921709545085324 0.8005858657467758 1.0 0.213603343153329 0.565670465397687 0.0224236752438935 0.949547299972159 0.236027018397223 0.461142974809555 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM3A -0.163741718030093 0.608940064793605 0.864960526893789 -0.289856514947098 0.358651038545644 0.70231184451666 0.286225097559884 1.0 0.0323328053133991 0.933540365474146 0.200323490501305 0.418019616659247 0.232656295814704 0.392953667792184 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TSG101 -0.0854549493063005 0.608943585057813 0.864960526893789 -0.0351811324184971 0.836774787487809 0.947349959049485 0.342002467388516 0.184268522308428 -0.516744193697704 0.0338000118174278 -0.174741726309188 0.474295673545989 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POP1 -0.184383045788234 0.609022669295541 0.864960526893789 -0.110993755661078 0.759775107007889 0.915406319729464 0.77994631653809 1.27696156867367 0.0119567298877919 3.0 0.075590932688879 0.899000427126128 -0.327680064233039 0.397054510194891 -0.25208913154416 0.581859167205675 partial_or_other False False False False False False False 0 insufficient_or_context_specific +Z84485.1 0.253315749126129 0.609064706218342 0.864960526893789 0.0401806933103322 0.935456871540144 0.981714106181567 True False False False False False False 0 insufficient_or_context_specific +BAZ2B 0.0720882133103393 0.609246823387233 0.864960526893789 0.0598255115193018 0.669686547883278 0.876261069841573 -0.0117542474578409 0.980581669633894 -0.670360502709326 0.0507824577073524 -0.682114750167167 0.0596104968577042 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC16A1-AS1 -0.130670823549529 0.609280366361245 0.864960526893789 -0.03420428160617 0.893286276111799 0.965828622958358 False False False False False False False 0 insufficient_or_context_specific +SSRP1 -0.124103662300017 0.609293823509476 0.864960526893789 0.0131427397987586 0.957628589483223 0.987656798648419 0.14205986992492 0.670597996258811 0.0603556924917965 0.822355995461389 0.202415562416717 0.464303626915761 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FOXJ3 0.0723365570890144 0.609586728279951 0.864960526893789 0.205246135883122 0.135126699987419 0.521860900181769 0.298889643125607 1.0 -0.034670088998745 0.919987746794769 -0.302754971319992 0.191190192383777 -0.337425060318737 0.177950741858584 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LENG8-AS1 0.137053705431813 0.609782703652755 0.864960526893789 -0.312725631188748 0.230558403015365 0.601518427890281 False False False False False False False 0 insufficient_or_context_specific +LANCL2 -0.13896953306222 0.609784339899492 0.864960526893789 -0.0852568197857831 0.752190879983405 0.912936120343119 0.371667776744812 1.0 0.0939006863583298 0.879379990100037 0.393799407139018 0.299958335899731 0.487700093497348 0.265979149348876 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NSFL1C 0.0994891384616417 0.609887538167661 0.864960526893789 0.0008311071945989 0.996757676482182 0.998795540446485 0.889457045154835 1.0 -0.36033218768544 0.183892054487953 -0.399958343329361 0.10245428481535 -0.760290531014801 0.012540209536432 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AAAS -0.140816681002788 0.610121139693234 0.864960526893789 -0.0059935639957342 0.98389787577616 0.99451887511202 0.393610698785965 0.928154623835879 2.0 0.811493916396761 0.011490521484707 -0.726441445637665 0.0119325691705398 0.0850524707590959 0.78370087562633 reversed False False False False False False False 0 insufficient_or_context_specific +SH3BP5-AS1 0.174616140369302 0.610127212529084 0.864960526893789 0.192487295309904 0.575592561815694 0.829928048970172 0.772809094870169 0.708321713885261 2.0 True False False False False False False 0 insufficient_or_context_specific +PAG1 0.183725991993892 0.610152665794228 0.864960526893789 -0.352504324966681 0.345588135433484 0.691144142244059 0.291419272062414 1.0 0.18564845838478 0.564274375022974 0.150392823635409 0.560692170362538 0.33604128202019 0.219649812596652 partial_or_other False False False False False False False 0 insufficient_or_context_specific +METAP1 0.122297268489801 0.61026029866178 0.864960526893789 0.173162444399794 0.465592627420441 0.770973488128139 -0.0780564603117952 0.862435148401668 -0.251363001471534 0.420731293292911 -0.329419461783329 0.326508998919213 partial_or_other True False False False False False False 0 cross_species_direction_conflict +F8 0.248346079437136 0.610627395320696 0.864960526893789 -0.0688969276120994 0.884183925944657 0.963081098449005 -0.112955904804658 0.815553359534416 0.579373250172416 0.0917276959525545 0.466417345367758 0.196915123897222 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SVIL -0.171145549080217 0.610828272724884 0.864960526893789 -0.116491192861839 0.727269364110306 0.903365569206837 0.35592862730835 0.259386958404755 2.0 -0.230579660416309 0.479518235398839 -0.546186139522282 0.058055025770816 -0.776765799938591 0.019553149402753 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDE2A -0.173901572344483 0.611039474735043 0.864960526893789 -0.514920422532067 0.102316326530187 0.479137456027696 1.28875897675964 1.0 -0.0340727549755546 0.936257534403958 0.280502483171349 0.318284874885417 0.246429728195794 0.417048387898766 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HORMAD2-AS1 -0.571396648816365 0.611047355536967 0.864960526893789 -1.37316577655887 0.185936029698483 0.56775396895769 False False False False False False False 0 insufficient_or_context_specific +MLXIP -0.0908237580787305 0.611074411656565 0.864960526893789 -0.0791036881056783 0.657219598814526 0.871691185476023 0.4658412283935701 0.4047043899499361 2.0 -0.492975090349664 0.26375158794362 0.261918653384199 0.495493510734479 -0.231056436965466 0.580208140143787 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NR4A3 0.491164405519805 0.611083985299567 0.864960526893789 -1.20179025268574 0.202444911027758 0.57668584531318 False False False False False False False 0 insufficient_or_context_specific +TMEM98 0.174685727066567 0.611110261179502 0.864960526893789 0.211151471856694 0.540422322794283 0.812904813230095 -1.16834273698818 0.0399475307784664 0.434784488150766 0.371425481360963 -0.733558248837411 0.146369950423067 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CREBBP -0.0759426496091709 0.611156336377652 0.864960526893789 -0.0497840275968543 0.738828799117776 0.907558041400239 0.106676260157302 0.701462933890149 0.136188043797097 0.528932237710709 0.2428643039544 0.284514590997784 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CARMN 0.215631934702911 0.611362953601912 0.864960526893789 0.0058131884681869 0.989390679796004 0.996896452948454 True False False False False False False 0 insufficient_or_context_specific +THAP12 -0.163020298047602 0.611417547628687 0.864960526893789 0.0072709978928753 0.983441822031701 0.99451887511202 0.168821397529355 1.0 0.349193170345816 0.322861778112018 0.169202513083467 0.564424993994051 0.518395683429283 0.110182982656765 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LDAH 0.0978894584791739 0.611474510528968 0.864960526893789 0.18930582053779 0.325150967520932 0.674724889947951 -0.487426638974383 0.0946616724159708 0.644572306713045 0.0195289238345715 0.157145667738663 0.562508519545956 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NAPA 0.119367404644754 0.611523853872957 0.864960526893789 -0.0632691865099341 0.787112597484471 0.926252207338503 0.314088194572161 0.0489388303552969 2.0 -0.278922290002186 0.214298541801216 0.353821195761756 0.0800324494252681 0.0748989057595692 0.738799988374757 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01290 0.249130473588163 0.611584417259923 0.864960526893789 -0.122675699645778 0.799499180904851 0.92964200904188 False False False False False False False 0 insufficient_or_context_specific +RPS4Y1 -0.509489518940797 0.611691082862127 0.864960526893789 -0.879654689260735 0.375556691391493 0.713241132346407 False False False False False False False 0 insufficient_or_context_specific +HCG17 0.0951514743170408 0.611731412608062 0.864960526893789 0.167906140622896 0.372562064747404 0.711175244911062 True False False False False False False 0 insufficient_or_context_specific +RAB4A 0.14028356553842 0.611895273747833 0.865076365858278 0.0713348316498881 0.797359458814571 0.92925379048471 -0.198550535944563 0.576327086579811 0.482559154288096 0.0884504795308971 0.284008618343533 0.338138135987812 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC025470.2 0.297799800715086 0.612185734516317 0.865232301380108 -0.0511392952619902 0.929188399496593 0.979665580375977 False False False False False False False 0 insufficient_or_context_specific +SEC31B -0.160867030994693 0.612298355242053 0.865232301380108 -0.0707136569327883 0.82502429920973 0.941168700714981 -0.832252535952612 0.0902795161189764 0.110293774397269 0.811666993082925 -0.721958761555343 0.112471157522687 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MPHOSPH9 -0.110189917760738 0.612806219024133 0.865517763981887 -0.246190556399233 0.241864133537583 0.608725035015447 0.389005083299575 0.547122657844943 -0.366021994697276 0.451110141435684 0.0229830886022986 0.973649631738477 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTI2 -0.1883047474757 0.612896998399098 0.865517763981887 -0.384684805657482 0.289242749504868 0.648508165061032 -0.254723949803451 0.44844746469326 0.189356493313525 0.492553941573279 -0.0653674564899258 0.844499257830434 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHSY3 -0.136503036007872 0.613103797015756 0.865517763981887 0.187044905882855 0.480868175811903 0.780346070738476 1.83700947384378 1.0 -0.148100334254059 0.828275929397972 -0.435036315654025 0.360109656849354 -0.583136649908084 0.269899919647458 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP2R1 0.16354458859002 0.613120087727884 0.865517763981887 0.169901481870699 0.600009276226804 0.843257280459236 -0.283869238356659 0.572999910138108 0.253420378909634 0.512284623401971 -0.0304488594470259 0.950559787025098 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MOSPD1 0.1786810563165 0.613159956735013 0.865517763981887 0.071374504712422 0.83988436183869 0.948598533621404 0.484899229215883 1.0 -0.0317143779886697 0.957440974715565 0.667462190566791 0.0758372035063263 0.635747812578121 0.124643592539909 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DGKA -0.206263030650583 0.613288759626062 0.865517763981887 -0.118643169060321 0.773698944068191 0.921597905470986 -0.330681052966754 0.380024802584681 -0.413619484996682 0.200709536829743 -0.744300537963436 0.0429561073522543 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC079193.2 -0.152474885543988 0.613354023940998 0.865517763981887 -0.0757290311735104 0.802157399548035 0.930781165449847 False False False False False False False 0 insufficient_or_context_specific +ST6GAL2 0.260790474324863 0.613408734341361 0.865517763981887 -0.30791704557614 0.556701619722569 0.820941061653668 False False False False False False False 0 insufficient_or_context_specific +MED27 -0.100093597964568 0.613437149827284 0.865517763981887 -0.0164779721491555 0.933809692945425 0.981304144333413 -0.45740423209225 0.123835076080789 -0.339628937161537 0.197369827353113 -0.797033169253787 0.0151546977337599 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMARCD1 -0.141890338841166 0.613786684901305 0.865895219025652 -0.380268790067847 0.164963208862749 0.545094551255265 0.131824509628757 0.769371208284727 -0.359049815276749 0.266760514227116 -0.227225305647991 0.542953914304661 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC104117.3 0.223985093758123 0.614576728045132 0.866553046086147 0.705196794243897 0.119887420821258 0.500502724013779 True False False False False False False 0 insufficient_or_context_specific +PPP1R1C -0.371711595183965 0.614600167643489 0.866553046086147 -0.320715661946341 0.668650593419147 0.875941737812246 False False False False False False False 0 insufficient_or_context_specific +KIAA0930 -0.147905795374649 0.614666819586973 0.866553046086147 -0.0834396519698874 0.778869627281555 0.922929913000972 0.525202507788491 1.0 False False False False False False False 0 insufficient_or_context_specific +RAPGEF2 -0.0968303968196588 0.614708956548676 0.866553046086147 0.0803045417877545 0.673577995397532 0.877738560778784 -0.233816249819504 0.418112008842998 -0.0143036877666577 0.959522727463866 -0.248119937586162 0.333678765436804 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POMT2 -0.141981113567163 0.614821004660311 0.866553046086147 -0.0139159789793976 0.961738447032148 0.989575531016998 -0.0354232125174898 0.938374068500702 0.19037924928129 0.524232761528258 0.1549560367638 0.6531446430029 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBC1D22B 0.0924716052830487 0.614827511671844 0.866553046086147 0.0645823374584212 0.723082925446956 0.901761106410224 -0.130111425626869 0.67711571393548 -0.43011551112731 0.0843666106969062 -0.560226936754179 0.0435720661617339 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SHANK3 -0.331951260429667 0.615204377058711 0.866724754945984 -0.534680453354949 0.41033518197603 0.735152897523944 0.121726455528061 0.764723842807102 -0.5722237579799 0.0699607968511128 -0.450497302451839 0.169010941645089 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP1R9B -0.147466807205927 0.615313609300798 0.866724754945984 -0.0495377206519011 0.86576703780437 0.958391272020028 0.427965709624584 1.0 0.418677972775224 0.178921506644886 -0.839595182463127 0.010255617334803 -0.420917209687903 0.150836743386005 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NDOR1 -0.196561389224369 0.615315529548393 0.866724754945984 -0.350722174160157 0.36137379793097 0.703277731139138 -0.187499594601182 0.538565227837334 -0.548833188829099 0.0415127576748528 -0.736332783430281 0.0178433403612881 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PMPCA -0.147393780207264 0.615996444325779 0.867088202872832 -0.312608430755811 0.283213259828934 0.644071250922027 -0.0072821830807444 0.982685585789729 -0.140897743022117 0.541763927308012 -0.148179926102862 0.559148364975836 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA0355 -0.0829852458902552 0.616014825227153 0.867088202872832 -0.239718863058452 0.141435982136475 0.526923646040233 0.6376954207905551 1.0 False False False False False False False 0 insufficient_or_context_specific +SLC26A5 -0.284668379353406 0.616071105244922 0.867088202872832 -0.984055840029258 0.0674582489882188 0.43786261079484 False False False False False False False 0 insufficient_or_context_specific +ARID3A -0.143208175636361 0.6161641114501 0.867088202872832 -0.0418585059847231 0.887047522250018 0.963622568156774 0.335427781580486 1.0 0.300224048163359 0.592444258755827 -0.994783300383627 0.0402647271604851 -0.694559252220268 0.163565371504678 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NKIRAS1 0.145232400324004 0.616469079522693 0.867088202872832 0.337285664304424 0.24672098230179 0.611905128292766 -0.406930638546671 0.137330353009854 -0.144072947753946 0.556601254886224 -0.551003586300617 0.0425572371467542 partial_or_other True False False False False False False 0 cross_species_direction_conflict +UTP14A 0.171770520205155 0.616480730329663 0.867088202872832 0.328361098262651 0.340395639039564 0.687922789857293 -0.12227633577044 0.718989599632534 -0.446877897794274 0.093970436715718 -0.569154233564714 0.0549533665136731 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLFN11 0.175389623985473 0.616521229301605 0.867088202872832 0.0949654748774173 0.786738460604881 0.926121604088118 0.607213742280665 0.053664536749179 2.0 True False False False False False False 0 insufficient_or_context_specific +CDH12 0.21793405120977 0.616648052276448 0.867107011294741 0.484268815495891 0.284125848257107 0.645043543745796 0.0164870593420313 1.0 True False False False False False False 0 insufficient_or_context_specific +TMOD3 0.0988058799031171 0.616698858478141 0.867107011294741 0.139572604903753 0.474972502825848 0.777120670205378 -0.0498866637069058 0.858341785703889 0.0539058898203183 0.797444438580025 0.0040192261134124 0.987327189296956 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TAF1A -0.19425736588155 0.616914237875818 0.867228290236618 -0.195848581860121 0.615042409379922 0.851375386684303 -0.0558473684686386 0.916492510478692 -0.715647975007212 0.0577080394056011 -0.771495343475851 0.0595901789757225 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STX6 0.121313940399907 0.616949392684906 0.867228290236618 0.280256895289446 0.242638745065634 0.609386138931985 0.328836554772445 1.0 -0.42762822516415 0.145429855379514 0.279108381031136 0.266469374743124 -0.148519844133014 0.595332156027235 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NAT10 -0.119760412373261 0.617396949072606 0.867435291585338 0.039353772553003 0.869767646872372 0.958502690861149 0.911878341706533 1.08478399351887 2.0 -0.146507347736134 0.661840388701911 -0.483613402424219 0.075737236332619 -0.630120750160353 0.0382849592925989 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AES -0.113968728900079 0.617452040110814 0.867435291585338 -0.293149200340352 0.179283330972574 0.562350982890208 False False False False False False False 0 insufficient_or_context_specific +PIGN -0.173873153222099 0.617560468919253 0.867435291585338 0.0835515099394175 0.808593627575441 0.932859303825974 0.512741111553351 0.111983612852235 -0.622292007557746 0.0358341438059579 -0.109550896004395 0.741088286917339 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTPAP -0.139992322451733 0.617589608528792 0.867435291585338 0.005413033023596 0.985134369984987 0.995307821007743 0.0922831629214419 0.814087629826335 -0.275670936608072 0.322285455025229 -0.18338777368663 0.5572780050764 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DAPK3 0.174098308134358 0.617955074285696 0.867490743698468 -0.0185931909386295 0.959246424158313 0.988456348454369 -0.373650321754627 0.204544353723281 -0.0813611356587956 0.770505482908639 -0.455011457413422 0.101891884760562 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF836 -0.14823722092069 0.618043833109889 0.867490743698468 -0.049323976568153 0.871510201174963 0.958683313195135 False False False False False False False 0 insufficient_or_context_specific +GSAP 0.112128082966874 0.618091374168086 0.867490743698468 -0.0482709054525995 0.827987194421378 0.94262333391211 0.633106205637147 1.0 -0.527347933712185 0.133260287707335 -0.239257916814398 0.441674253571125 -0.766605850526582 0.0321406638843243 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL37 0.135927854245871 0.618223077076614 0.867490743698468 0.519819315143363 0.0590970602101198 0.428240742414856 True False False False False False False 0 insufficient_or_context_specific +AC021231.1 0.171953373027092 0.618424532268391 0.867490743698468 0.153716470136402 0.656680417236417 0.871684912617742 True False False False False False False 0 insufficient_or_context_specific +AC007495.1 -0.158466570402178 0.618547926279004 0.867490743698468 -0.184545470946995 0.561568388038021 0.823291102966203 False False False False False False False 0 insufficient_or_context_specific +PPARD -0.161128457797811 0.618648693233804 0.867490743698468 -0.317173411193666 0.322474856390685 0.672877524535327 0.525448018348539 0.304654947968951 0.0840152685767916 3.0 -0.259083271403677 0.476266397519509 -0.0152421735950725 0.965522130739903 -0.274325444998749 0.391066531392025 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NASP -0.0872807633472154 0.618679295367518 0.867490743698468 -0.225906624383997 0.193622117494723 0.570885363891703 -0.125970032385325 0.757499856163241 0.0741672453175572 0.817759779332785 -0.0518027870677678 0.890125841146633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MUC20-OT1 -0.0730063073559631 0.618726302515057 0.867490743698468 -0.115444969110451 0.431691580732742 0.750378615307258 False False False False False False False 0 insufficient_or_context_specific +FGF2 -0.206032968907982 0.618792643692506 0.867490743698468 0.145233655302277 0.725900307068188 0.903365569206837 0.150792257506285 0.706999972180783 -0.555611819303334 0.0786270911010679 -0.404819561797049 0.228183888125089 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HECTD1 -0.0639105624238653 0.618861745498809 0.867490743698468 -0.0172662265391353 0.892616732259911 0.965500200717154 0.0782874335283712 1.0 -0.0339177371463222 0.930095922530229 0.0845739592842414 0.757422335555981 0.0506562221379192 0.871823884109414 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHCHD10 0.152612983005168 0.618913015812771 0.867490743698468 0.265132965655657 0.389802852558513 0.722218665388488 0.862029692777056 1.0 -0.924640207948804 0.0976254567464896 1.47342541767866 0.011706710541436 0.548785209729856 0.280810888564454 reversed True False False False False False False 0 cross_species_direction_conflict +FAR1 0.0942760727045852 0.618925109133462 0.867490743698468 0.187472048990044 0.337319541407932 0.685057785656405 -0.102621275402491 0.818487492545931 -0.760171479108719 0.032704839480498 -0.86279275451121 0.0256044158332625 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RAB3GAP2 -0.0687956751116848 0.619292966587655 0.867724358075884 0.0201469361274781 0.883841106107467 0.963081098449005 0.275843931404445 1.0 0.132862115046829 0.703159281983927 -0.551108603989703 0.0531351360962659 -0.418246488942874 0.151742713201679 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OSTF1 -0.15380184496903 0.61938876749238 0.867724358075884 -0.117929820621222 0.704770747715485 0.892309576013921 1.15220508063216 1.0 -0.278711186347711 0.259415593336299 0.60832222207999 0.0134538631575704 0.329611035732279 0.144268726784596 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM13B 0.0877153425317696 0.6196614653749 0.867724358075884 0.151484911700781 0.38996899857524 0.722218665388488 -0.048590616362854 0.883206679897385 -0.309986410741871 0.174687341626434 -0.358577027104725 0.142354331025292 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AP001605.1 -0.251497542035653 0.619841827527356 0.867724358075884 -0.111172569973251 0.828192544624194 0.942755459422344 False False False False False False False 0 insufficient_or_context_specific +ZBTB8OS -0.103343014746956 0.619887820334386 0.867724358075884 -0.172484946564681 0.403989866803142 0.732496138366405 0.399184784673505 1.0 -0.323471073569616 0.268445622372792 0.458704339657921 0.0711432371612225 0.135233266088305 0.625684793517683 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBLCP1 0.103141505740421 0.619910150724769 0.867724358075884 0.175062114220998 0.408429333924655 0.734801770489731 -0.0243207626734341 0.966784957440745 0.409390681977087 0.275368405729551 0.385069919303652 0.352956736180375 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SUPV3L1 -0.0945148242737408 0.619932263020117 0.867724358075884 -0.229844962076711 0.215038312569842 0.587852789707652 0.399729196962655 0.172129406616575 -0.311650812339655 0.198431053226562 0.0880783846230006 0.77126327436855 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF142 0.102518160743874 0.62013255724275 0.867761634779139 0.0598853193511824 0.774085862499675 0.921709545085324 True False False False False False False 0 insufficient_or_context_specific +AC074032.1 0.100182997775053 0.62020068311539 0.867761634779139 0.149660326388665 0.460579747917604 0.768745132096508 True False False False False False False 0 insufficient_or_context_specific +LASP1 -0.150891475601874 0.62036919739175 0.867761634779139 -0.502934236742409 0.0947034763956894 0.474551164587418 0.43619267083817 1.0 -0.236887358882098 0.45348189818789 -0.204845950512693 0.443347560963157 -0.441733309394791 0.118941592988843 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP4S1 -0.0975380159897828 0.620490342886228 0.867761634779139 -0.0079752085316421 0.967789567896566 0.991065707083724 0.0213207168015096 0.95762493377024 -0.0193710356436087 0.949862975950138 0.0019496811579008 0.996208913330024 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDK14 0.102164704721951 0.620605030258279 0.867761634779139 0.331097229575283 0.0909577216970862 0.472234212482528 0.124068923218084 0.164618305288791 2.0 -0.0281348351925459 0.940579315235297 -0.217499517967731 0.391404224752196 -0.245634353160277 0.361744201563241 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC243964.2 -0.270241358967202 0.620618973863233 0.867761634779139 -0.809575589285249 0.138212318101073 0.523810858054217 False False False False False False False 0 insufficient_or_context_specific +PAFAH1B1 -0.0551090970228973 0.620749931887129 0.867761634779139 -0.0299899945836722 0.784321603532238 0.925443394064972 0.851543954004634 1.0 -0.0409841934196695 0.893567523982346 0.0212021190564349 0.930852252028654 -0.0197820743632346 0.939802624314014 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CRHBP 0.37331514472729 0.621045245016402 0.867761634779139 -0.0379003100057295 0.959506151955607 0.988617762369409 False False False False False False False 0 insufficient_or_context_specific +CDH19 0.250965380575371 0.621179565613935 0.867761634779139 -0.229645404147192 0.667377376933439 0.875419277100913 0.170835153181167 1.0 False False False False False False False 0 insufficient_or_context_specific +CD81-AS1 0.152712544844176 0.621203010770872 0.867761634779139 0.161770628851059 0.601825204159245 0.844282554546015 0.7066769684511272 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF281 -0.188502720920168 0.621269417798911 0.867761634779139 -0.325196542409588 0.388125800630867 0.721576369618013 1.74905889581588 0.008396007686556541 2.0 False False False False False False False 0 insufficient_or_context_specific +CA3 -0.173607212162745 0.621277601697101 0.867761634779139 -0.0171439529638832 0.96061299038514 0.988899371342269 False False False False False False False 0 insufficient_or_context_specific +EIF2B2 -0.195225270428461 0.621320953561242 0.867761634779139 0.0278432726685582 0.94273773516837 0.984366565940656 0.464169688179945 0.297263695934094 0.206905278565393 0.556601254886224 0.671074966745338 0.101160881693041 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HGS 0.112515787274303 0.621335738323629 0.867761634779139 0.0696641119926671 0.759624935949158 0.915406319729464 -0.400473704110301 0.108668572802626 -0.10179685568101 0.656421353176508 -0.502270559791311 0.0419004422649963 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DUSP6 -0.201779720789594 0.621356124164642 0.867761634779139 -0.484817344196201 0.221643729856146 0.592957341103408 0.284501973541029 0.570333397214886 -0.353089094694489 0.385986481338582 -0.0685871211534601 0.891195063774748 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XIST 0.757657538026135 0.621469661806672 0.867805407929486 1.78471192758478 0.260001637563418 0.622885940784012 1.59245606969507 0.286099648948244 0.663137541715168 3.0 True False False False False False False 0 insufficient_or_context_specific +MKRN2 -0.150638312085032 0.622502098392396 0.868692072587301 -0.246180148169482 0.42040064625263 0.742363275319495 -0.41178987941804 0.4498909870042 0.0087001581232979 0.987380618750829 -0.403089721294742 0.402930973403266 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CD109 0.255561858459808 0.622574268675873 0.868692072587301 0.165051613847127 0.750378462935453 0.911659131290248 0.16438762836931 1.0 True False False False False False False 0 insufficient_or_context_specific +COL21A1 -0.265207683670093 0.622576461070172 0.868692072587301 -0.12945433702902 0.810781494275156 0.933438195229734 0.4057935727781251 0.8521492958913891 2.0 False False False False False False False 0 insufficient_or_context_specific +MBD2 0.0889082054245839 0.622723732449482 0.868692072587301 0.0729431885666442 0.686217982379445 0.88376304683608 -0.306017471398275 0.256752375389647 -0.193861303715687 0.414905092589624 -0.499878775113962 0.0556752012051446 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ETNK2 -0.441823161340901 0.622729520507642 0.868692072587301 -0.536276986597949 0.548370313033003 0.816156774016399 -0.969713369190233 0.0292911065356601 1.30226163719725 0.0058788602570602 0.332548268007014 0.392366273210751 reversed False False False False False False False 0 insufficient_or_context_specific +RNPEPL1 -0.161461809709734 0.622951014821618 0.868692072587301 0.0316413603566278 0.924767496887029 0.978480541854262 0.0136094088724326 1.0 -0.0271343477769399 0.933769708445007 0.098000771104772 0.667102969240791 0.0708664233278321 0.781225184787245 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPR107 -0.075977937520374 0.623139257816739 0.868692072587301 0.0317870707200902 0.835678548396121 0.94678550423503 1.24672714499158 1.0 0.0553046607259714 0.876433216394697 -0.132069703303563 0.597455102459263 -0.0767650425775916 0.791773459299581 partial_or_other False False False False False False False 0 insufficient_or_context_specific +G3BP2 0.0870531433089245 0.623360515840408 0.868692072587301 0.0651575904368719 0.714301380160936 0.896314947912902 -0.0079893375074615 0.980581669633894 -0.0011854810266308 0.996555209923278 -0.0091748185340923 0.973765834081683 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF69 0.113777912684548 0.623370825424107 0.868692072587301 -0.30788860467975 0.196496589291459 0.571879675616801 0.376065495083695 1.0 False False False False False False False 0 insufficient_or_context_specific +TCFL5 -0.133443410504032 0.623397663061365 0.868692072587301 -0.077092478552818 0.780669455819706 0.924025573379424 0.38582738425649 1.0 False False False False False False False 0 insufficient_or_context_specific +RNF10 -0.0791977174592956 0.623418907269125 0.868692072587301 -0.120472079857912 0.446170785169162 0.76113607203361 0.00471316608322098 1.0 0.0508714874063636 0.896279981245266 -0.0090911770078558 0.977298565070146 0.0417803103985077 0.89931880437347 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RGL2 -0.161434968268055 0.623421086758285 0.868692072587301 -0.268599736110607 0.407486151683883 0.734170441890517 -0.233823647464229 0.510718702477573 -0.704374981475772 0.0303215400480226 -0.938198628940001 0.0126248093633789 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CD151 -0.180313209679496 0.623580488394148 0.86879375117011 -0.448735214396311 0.203376745610804 0.576835372560841 -0.16205950781779 0.602051276048176 0.574063792013808 0.034065362138785 0.412004284196019 0.120165656424058 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SH2D4A 0.200667142051359 0.623658632327928 0.86879375117011 -0.0363917401136265 0.930281316888283 0.980230553264121 -0.382540212059663 0.47070775974577 -0.19202524677059 0.6713392888627 -0.574565458830253 0.22144388111188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CWF19L1 0.106253205425278 0.623974433045245 0.868949035723208 -0.12675897376336 0.525066988589443 0.804676662787375 0.200024593964257 0.703159281983927 -0.162025263578039 0.682704508639698 0.0379993303862184 0.940961636105127 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIM27 -0.103982503364802 0.624054646320081 0.868949035723208 0.174421518246215 0.404368851170161 0.732758892415649 -0.314708885947923 0.31057796670795 -0.378421824642427 0.162988592868205 -0.69313071059035 0.0286396896992657 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPS12 0.182980442112026 0.624099312169832 0.868949035723208 0.335023326112428 0.366600841194615 0.707896919588155 True False False False False False False 0 insufficient_or_context_specific +AL022068.1 0.182374770634017 0.624428721261408 0.86918098151846 0.61654105770877 0.102157279957132 0.479137456027696 True False False False False False False 0 insufficient_or_context_specific +EPOR -0.180198576481757 0.624439098017195 0.86918098151846 -0.520821963978787 0.129546573769925 0.514452719557911 -0.756919633837462 0.111983612852235 0.787554276121697 0.0628258187193038 0.0306346422842345 0.950559787025098 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TPRG1 -0.208694076631395 0.624512874199568 0.86918098151846 -0.317886796600004 0.453978802378601 0.765695541335292 False False False False False False False 0 insufficient_or_context_specific +CASP10 0.138841802923292 0.624610199733391 0.869201856963904 -0.0136664903054864 0.961530018977029 0.989457499060377 0.734300419044815 1.0 False False False False False False False 0 insufficient_or_context_specific +SAP25 -0.170679669683714 0.624740632280311 0.869267203012868 -0.0603027542118217 0.868630281820203 0.958502690861149 0.0337764393618462 0.940685645135291 -0.903058089101811 0.0128414079521595 -0.869281649739965 0.021590288273071 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DOK4 -0.169619042090062 0.624828112121906 0.869267203012868 -0.205336219971012 0.548684381730684 0.816365047001981 0.6063793837858371 1.0 0.0218980160239512 0.969651685100975 -0.129082704751688 0.743436689765675 -0.107184688727737 0.820795203351876 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIP6 -0.16325074611746 0.6249041552252 0.869267203012868 -0.309436493920695 0.347102187539316 0.691976000007571 0.275573431691431 0.366014408248237 -0.618316907980599 0.0273407528137498 -0.342743476289168 0.225744774506919 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TNFRSF10B 0.145059450808309 0.625582256725427 0.869837788959148 -0.0157721216707029 0.958387801017662 0.988150234682077 1.26068388159779 0.0873332495759678 -1.75553412650366 0.012521026758255 -0.494850244905872 0.563000775166288 reversed False False False False False False False 0 insufficient_or_context_specific +CASTOR3 -0.116674362111504 0.625652426981478 0.869837788959148 -0.0987889810546538 0.680468429895661 0.881048329971919 False False False False False False False 0 insufficient_or_context_specific +RSRC1 0.0692148807854531 0.625685278439841 0.869837788959148 0.143463988438435 0.30836498198559 0.662330926800867 -0.29678294367349 0.501174055440694 0.13050890936692 0.724863774561987 -0.16627403430657 0.685035523624829 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AP3B1 0.0689105532126003 0.625919140028088 0.869876830382592 0.205147446643181 0.138617876245831 0.523810858054217 0.282099497727455 1.0 -0.223467604233545 0.343534692169519 -0.28957799377195 0.159694953493331 -0.513045598005495 0.030135639991491 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AGBL4 -0.207232637389967 0.626099320154273 0.870012716792421 -0.247181500529529 0.558489277809542 0.821540505706147 False False False False False False False 0 insufficient_or_context_specific +ELP4 0.0731409834445998 0.626303756848274 0.870182269351767 0.128603059614114 0.386906201550427 0.720477739899883 -0.256487306627247 0.417766539026701 0.380600765990098 0.14086559936413 0.124113459362851 0.676180017484306 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ITIH2 -0.171684606579189 0.626464992934945 0.870243693079394 -0.0086756125592246 0.980303557575293 0.994014064108846 -0.571961457099138 0.255488092210607 0.857188933401358 0.0640120759471843 0.28522747630222 0.548851241821563 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRUNE1 0.0938378847255973 0.626512815978071 0.870243693079394 -0.0807462950186707 0.675665097112792 0.878855746620285 0.388131057763704 0.379515615712071 2.0 0.105079974445357 0.80772018428236 0.250435666986767 0.380582259307618 0.355515641432124 0.270837838433461 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCCA -0.0740837034379731 0.626799860731342 0.87052787813753 -0.141335316429766 0.354468155820456 0.698014991474228 -0.556689737643338 0.0314799982455891 0.459682861910207 0.0480642902030865 -0.0970068757331312 0.694154803915601 reversed False False False False False False False 0 insufficient_or_context_specific +SLC11A2 -0.103606328328186 0.626903824886631 0.870557751302519 -0.0066406224076956 0.975178567200876 0.992701163073476 0.250814714665942 0.335016136540797 2.0 -0.248974941518896 0.406176202037425 -0.248666817765654 0.326146528483505 -0.49764175928455 0.0754245379612838 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ELP1 0.084785804630172 0.627169798628542 0.870771681549062 0.262262821845924 0.124452084352868 0.506540133615104 0.0327335436527937 1.0 -0.0214115205745608 0.952376258663084 -0.468633778412286 0.061744947592522 -0.490045298986847 0.0688307560056457 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DNAAF2 0.129766299467196 0.627222829909132 0.870771681549062 -0.0757627414409037 0.771512787890113 0.920641521976153 1.09564417454633 0.216414362388195 -0.223475429654181 0.725594259838567 0.872168744892145 0.297092984956326 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UMPS 0.179427398162785 0.627352959299096 0.8708378312227 -0.19556657560479 0.587783093521816 0.835274227991216 0.58346107753461 0.151363323367227 -0.222128711426367 0.514249519157011 0.361332366108243 0.339365923833076 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC016727.1 -0.199485151420967 0.627763475421662 0.871073909324171 -0.76369335386611 0.0421154393750707 0.3908928278867 False False False False False False False 0 insufficient_or_context_specific +AUP1 -0.15260903655472 0.62780564266579 0.871073909324171 0.0563166572028085 0.858916119356678 0.956914759994669 -0.183796103398803 0.515153074473605 0.240279802520813 0.300047578556651 0.0564836991220104 0.838355949684886 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMCO4 -0.0934666124001007 0.627902190446883 0.871073909324171 -0.0215947881641243 0.910406161027377 0.972012437182896 -0.332092668901504 0.342049359871133 -0.149595955576883 0.627063926699736 -0.481688624478387 0.135142113331727 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM221A -0.175953720222597 0.628015314128148 0.871073909324171 -0.437604014691907 0.214997606293396 0.587852789707652 False False False False False False False 0 insufficient_or_context_specific +AK3 0.0945657458202201 0.628018052450804 0.871073909324171 -0.115691822557671 0.54151510412669 0.813832817790235 0.064637424430289 1.0 -0.647576567683717 0.0807520955159233 1.17557902470019 0.0049941280003883 0.528002457016474 0.122271930094351 reversed False False False False False False False 0 insufficient_or_context_specific +GLUD1 -0.126036375945602 0.628370504542992 0.871206838167602 -0.334128560720971 0.194720425077098 0.571343735852293 0.210314791066115 1.0 -0.213694237173751 0.690338205187223 0.441996913966614 0.29483870549823 0.228302676792862 0.622886710923478 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00240 0.240606726189378 0.628397953397016 0.871206838167602 -0.0770755645964085 0.878449138088136 0.961432567887278 0.0149717853549346 1.0 False False False False False False False 0 insufficient_or_context_specific +SPATA9 0.183259956330439 0.628416554216681 0.871206838167602 -0.0672024728633691 0.859014039536304 0.956914759994669 0.39737184647987 1.0 False False False False False False False 0 insufficient_or_context_specific +HMBOX1 -0.145091900260343 0.628477551158238 0.871206838167602 0.0769493735525583 0.795715944377852 0.928705441354941 0.186883929752979 0.542888424064452 0.169672853629678 0.490222053010812 0.356556783382657 0.176972577590427 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBKS 0.136457828646753 0.62864035588993 0.871206838167602 0.206869797808622 0.463147018138346 0.769320698854699 -0.292841162735549 0.42501327819279 0.296092859480886 0.306474205179963 0.0032516967453373 0.993999298012455 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SEPT10 -0.0762121765933794 0.628691504072643 0.871206838167602 -0.191066775974378 0.201763688834567 0.576358502899178 -0.119851541561906 0.720455810949913 0.198690690040851 0.432305383306481 0.0788391484789446 0.792957248993736 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WTIP -0.119859832502554 0.629005261102994 0.871419437447316 -0.0630705755092595 0.800448895616437 0.930088303753618 0.414458014260744 0.216440968955413 -0.756510436282081 0.0209075526994442 -0.342052422021337 0.2767083651191 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IL6ST -0.106601455488487 0.62900999552813 0.871419437447316 -0.237460192164796 0.276808076787322 0.639925481655474 0.403140367692063 1.0 0.663022036464801 0.0692404679085664 -0.29209939472388 0.359911898746699 0.370922641740921 0.266378084201605 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLF2 0.0874701506797621 0.62922545169668 0.871514626985652 -0.0477415666483419 0.794038627867708 0.928063228447907 0.343902180508465 0.228393348975655 -0.586668214043133 0.0316145957401416 -0.242766033534668 0.361388294939853 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIP4K2A 0.150429078176576 0.629938845096821 0.872134058029405 0.157286726676383 0.614353939511577 0.851115193985465 -0.0679619986140301 0.883206679897385 0.184625368134401 0.555142785786831 0.116663369520371 0.749175970916833 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TM6SF2 -0.3348351967362 0.630306131228054 0.872470541581923 -0.277691095148766 0.692859531069139 0.886799724697293 0.0902763217067898 0.886160063065692 0.278009677996967 0.490222053010812 0.368285999703757 0.417989039473479 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KDM6A 0.10193910875627 0.630347157718025 0.872470541581923 0.292224940102923 0.162361133933392 0.544121887728627 -0.148868262080463 0.630280145364912 -0.219341704235532 0.366873281626793 -0.368209966315995 0.160529390011164 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NMNAT3 0.10726049551222 0.630626230674548 0.872570190515022 0.0681280342210493 0.759287470162569 0.915406319729464 -0.312386863292217 0.567542032046759 -0.588399744113353 0.188779811122874 -0.90078660740557 0.0765563294026887 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CAMTA1 -0.0739546291750554 0.630690849795219 0.872570190515022 0.026154516682495 0.866252883743264 0.958391272020028 0.499004699954821 1.0 0.291351188925761 0.414772310926076 -0.93930407407978 0.0093613596907365 -0.647952885154019 0.0615733825294236 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C21ORF2 -0.202917867778463 0.630875099469418 0.872570190515022 -0.279517353239483 0.50443008699319 0.792758405693685 False False False False False False False 0 insufficient_or_context_specific +DENR 0.108141820150906 0.630953840266763 0.872570190515022 0.146786773552871 0.511718791763136 0.796979938550699 0.350209925332987 1.0 -0.197102298816844 0.499904899496559 0.226076349048195 0.340711704421801 0.0289740502313512 0.922505202223034 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZBTB26 -0.12287362755626 0.631562360627876 0.872832276143984 -0.170462696399498 0.498833590887599 0.7899705952391 0.678683296644468 1.0 0.190291943720915 0.784039873542692 0.334236309267958 0.460104259739413 0.524528252988873 0.32001027915736 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYCP2 -0.152739261684696 0.631571182953795 0.872832276143984 -0.0758108863566188 0.815391525516239 0.935953873276848 False False False False False False False 0 insufficient_or_context_specific +GK 0.196768189424297 0.631600548374696 0.872832276143984 0.462312573596524 0.243872234206174 0.610315684654444 -0.0282395517157911 0.942319881739737 0.150984933575559 0.569914140015829 0.122745381859768 0.681582139384856 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BCL9L -0.11168267689341 0.631824200178875 0.872928132468598 -0.199582893934652 0.380860176144512 0.717161002271046 0.504846117550928 0.345918001883753 2.0 -0.323759242079735 0.231965813066577 0.0926947575761863 0.71263598735696 -0.231064484503549 0.35417011873624 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARRDC3-AS1 0.198318180379871 0.631864331157167 0.872928132468598 0.626929319312525 0.139206216072742 0.524072738828147 True False False False False False False 0 insufficient_or_context_specific +ZDHHC6 -0.111296069974423 0.631973521613073 0.872928132468598 -0.123738028394071 0.594197948803571 0.839944027777226 -0.10032055469569 0.813377867232966 0.406465517180944 0.179506796946851 0.306144962485254 0.339137138492324 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SDC2 -0.131282874685754 0.632000629341728 0.872928132468598 -0.0309159921044339 0.910220311553078 0.972012437182896 0.568754317241611 1.0 -0.484000565444293 0.215880309674454 0.922860590600192 0.0178950704989978 0.438860025155899 0.219318094352611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RSAD1 0.128305053586544 0.632126529544905 0.872987821966659 -0.0251078920529672 0.929825442785056 0.979967786975403 0.349624574297863 1.0 0.950549469204553 0.0784010784296727 -1.04755724216681 0.0309928578466738 -0.0970077729622552 0.8741276256463 reversed False False False False False False False 0 insufficient_or_context_specific +TRIM73 -0.198314200983423 0.632627657229463 0.873337186849983 -0.27929545319575 0.499967210813211 0.790809559815114 False False False False False False False 0 insufficient_or_context_specific +LIN7A 0.103879145517093 0.633048216272587 0.873531105559329 -0.0255538992031956 0.907790241528755 0.971364079260221 -1.38732862708843 0.0092882287928067 0.940454371129511 0.0371548253205599 -0.446874255958918 0.285252262054737 reversed False False False False False False False 0 insufficient_or_context_specific +CPLANE1 -0.0675311166603697 0.633256838282613 0.873531105559329 -0.0080521969035197 0.95543019944346 0.987410276805219 0.648982222219092 0.130855823148545 -0.029037137788269 0.94109271294316 0.619945084430824 0.123610807808244 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAP1GAP -0.321327256273982 0.633402733166 0.873531105559329 -0.435204167646498 0.513143781603903 0.798308503171783 0.0356292221887366 0.971062977950832 -0.987609967929508 0.152375744421799 -0.951980745740772 0.232991998640449 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MDM4 -0.0775709283808868 0.633441752572829 0.873531105559329 0.0227730863698542 0.890335344888321 0.964713393362605 0.5933449864836129 0.35405892064466 2.0 0.0652536209191972 0.852146947349664 -0.62737162644738 0.0226417772382221 -0.562118005528183 0.0431328599366408 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDE1C 0.255549727810923 0.633549676183118 0.873531105559329 0.392756441792688 0.467270696805652 0.772298687675966 0.0485864853240529 1.0 True False False False False False False 0 insufficient_or_context_specific +PRLR -0.289110104729326 0.633577293134515 0.873531105559329 -0.812979833149653 0.159513259161461 0.543271287169906 0.315785384016396 1.0 -0.287813099885446 0.654055731660513 0.626903395736949 0.203645474047612 0.339090295851503 0.530081663735485 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARMH1 -0.235963701392751 0.633595905219048 0.873531105559329 -0.619056387478326 0.201683917416619 0.576305465780752 False False False False False False False 0 insufficient_or_context_specific +PPP4R1 -0.111806587586501 0.633655290309417 0.873531105559329 0.0530152946316035 0.823259643918378 0.939774604875147 0.506055595890734 1.0 0.311710099086829 0.324918694900994 -0.557275943515894 0.0491508668288 -0.245565844429065 0.406406083171812 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NSRP1 -0.0679630170809767 0.633906950059215 0.873531105559329 -0.0138144510980382 0.923443871852628 0.978003851842718 0.739237073013362 1.0 -0.17447367640389 0.533138911232709 -0.103782469770046 0.659239232256522 -0.278256146173936 0.249748506666387 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP2A2 -0.106490825853697 0.634055384219146 0.873531105559329 -0.0541780544138615 0.808807924533336 0.932859303825974 0.702338705900611 0.17584670035646 2.0 -0.41762331315173 0.243454500089532 0.163548383208019 0.615490764938628 -0.254074929943711 0.442967053498642 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RTF2 0.109265686872632 0.634078228637208 0.873531105559329 -0.11112804422068 0.637950198944497 0.863120280388885 -0.608889063880933 0.175144956637759 1.02254056265884 0.0191416417411355 0.413651498777907 0.306190223978868 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF780B -0.0772168105251411 0.634080957160375 0.873531105559329 -0.117772981838744 0.46817447583415 0.772583012794147 False False False False False False False 0 insufficient_or_context_specific +CPB2 -0.274758622055419 0.634111559786049 0.873531105559329 -0.441572895203132 0.443525195134427 0.759445184922036 -1.03638581657239 0.0032349170501253 1.03591772834943 0.0033153324742288 -0.0004680882229634 0.999089144569744 reversed False False False False False False False 0 insufficient_or_context_specific +SMC5-AS1 -0.154586441857294 0.63413822205562 0.873531105559329 -0.432083241525677 0.167793205701951 0.547623080618609 False False False False False False False 0 insufficient_or_context_specific +PIN1 0.152021607890473 0.634141575157169 0.873531105559329 0.179166273577473 0.576043345491348 0.829928048970172 -0.121266662442399 0.745230863995707 -0.284658322225555 0.304964104645327 -0.405924984667954 0.177904366749501 partial_or_other True False False False False False False 0 cross_species_direction_conflict +XKR6 0.117507020737429 0.634179418870227 0.873531105559329 0.26122826993011 0.292035916715156 0.651509781962399 -0.929255455173834 0.146574178443169 0.0931234520772164 0.886097501167603 -0.836132003096618 0.155047948809902 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ME3 -0.129393589947501 0.634257383521293 0.873531105559329 0.0476946104377714 0.862143100018664 0.957822965712685 1.05377896581167 1.0 -1.27714636814728 0.0823610216722899 0.437047641139578 0.504791351860363 -0.840098727007698 0.194539022192911 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDAH2 -0.20756133877704 0.634456387203808 0.873605800019279 0.0786533890777788 0.86179628544178 0.957822965712685 0.886395012826866 0.022784208387205 -0.930115750473068 0.011706710541436 -0.043720737646202 0.916468942306155 reversed False False False False False False False 0 insufficient_or_context_specific +SMURF1 0.0746285764460709 0.634477104996006 0.873605800019279 -0.0442473750175505 0.77868707018865 0.922929913000972 0.393853025626193 1.0 0.0343563395547445 0.941110137041743 -0.297596206928652 0.337471033205884 -0.263239867373908 0.432792874395078 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CD74 0.263255790943485 0.634816030190437 0.873844543253016 0.333231688609489 0.548337902426533 0.816156774016399 -0.981463493250563 0.178688355424681 0.355121416252637 0.590613521405204 -0.626342076997926 0.349634261473776 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLPP3 -0.170904405240105 0.6350085315394 0.873893381039643 -0.313747132710973 0.379341482868099 0.716345443770593 -0.32477521807765 0.314206308716963 0.743070721443205 0.018670071323126 0.418295503365554 0.153896366055526 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRMT3 0.105830773457035 0.635065254462223 0.873893381039643 0.0987044879678516 0.658194967682617 0.871691185476023 -0.0845446665648538 0.873366340866357 -0.677655434918049 0.0774466242472505 -0.762200101482903 0.0715756199704101 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IFIH1 0.151038667616764 0.635099821246181 0.873893381039643 0.345180129846915 0.28179853675246 0.64315368591277 -0.353543630695121 0.176046001729535 0.278116578317959 0.225055801993709 -0.0754270523771624 0.777636572475041 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZBTB5 -0.122607604929351 0.635412574931931 0.874102482235571 -0.108135028812934 0.676537356574096 0.879146834479876 0.0193115736608545 1.0 -0.3629770875056 0.298719294470336 -0.208700753134508 0.492553941573279 -0.571677840640107 0.0841386481081688 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COL5A1 -0.166808151491265 0.63570311226076 0.874102482235571 0.0016086367095214 0.996388238062465 0.998795540446485 0.9107924276344691 0.993851589184052 0.227527853521681 3.0 0.0739599354333451 0.867387110277452 -0.271240034741007 0.385848950412737 -0.197280099307662 0.559657510807534 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL033504.1 -0.139886330485112 0.635708329926447 0.874102482235571 -0.0251918583796937 0.931380860752854 0.980801828029986 False False False False False False False 0 insufficient_or_context_specific +ZNF609 -0.054956430174327 0.635764207664435 0.874102482235571 -0.0672982461552302 0.55682095326722 0.820941061653668 False False False False False False False 0 insufficient_or_context_specific +WT1 0.370241353315034 0.635831318769577 0.874102482235571 -0.0643959319710621 0.934315816842296 0.981347631737064 0.322099523684584 0.017350597460719 2.0 -0.527945556862559 0.398946724452772 -0.313022092395767 0.567772032951662 -0.840967649258325 0.139869983394125 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CIZ1 0.110029741455434 0.63596353796885 0.874156301108355 -0.173077122572919 0.460492529215963 0.768745132096508 0.514341711821459 1.0 -0.154378495587224 0.638254095534957 -0.629008100804942 0.0293858043039421 -0.783386596392165 0.0166103251086719 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FGB 0.154523185416944 0.636124251025827 0.874163717601286 0.377950410957028 0.243580404425347 0.610135684441949 -1.64146590570044 0.0025660399388253 1.22122759649566 0.0097635853300139 -0.420238309204778 0.299849251495244 reversed True False False False False False False 0 cross_species_direction_conflict +ST6GALNAC3 -0.24905648722702 0.63621818176984 0.874179016544244 0.113024728051883 0.828788885517362 0.942925975570292 0.405524406470882 1.0 0.318007138721746 0.699085055213677 -0.261338683418572 0.659103683389312 0.0566684553031739 0.943350111093624 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAL1 -0.102928699097403 0.636496313737362 0.87444737546377 0.177618994203975 0.412372301049571 0.735291083225579 0.265034808556793 1.0 -0.0753938066584999 0.8890677464436 -0.621791960608012 0.103025106484495 -0.697185767266512 0.0981713682525056 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP001636.3 -0.404871208947091 0.636892268872039 0.874830174411007 -0.840690506793489 0.306617845470274 0.661696690217148 False False False False False False False 0 insufficient_or_context_specific +VAMP3 -0.155904064897761 0.636940665911859 0.874830174411007 0.469772167806379 0.137544215991601 0.523810858054217 0.362857637071925 0.205814568733279 0.0124504948186186 0.964263052426797 0.375308131890544 0.158360781712976 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAD51C -0.10775723108848 0.63713876860942 0.874988438993009 -0.34967356594138 0.0992431803174793 0.478125555523304 False False False False False False False 0 insufficient_or_context_specific +USP16 -0.0809812421291857 0.63736482938698 0.875105227838859 0.0313506094239764 0.856593647695208 0.956623199954094 0.15012732832966 0.619448844262514 -0.218039515709053 0.357047123824387 -0.0679121873793928 0.812201448650283 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BTNL9 0.446987527131359 0.637426676038514 0.875105227838859 -0.0781251652791313 0.933145585436531 0.981085441734921 0.375396184633519 0.41730467354195 -0.136588155040882 0.714631825406034 0.238808029592636 0.58142880893334 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GOLM1 0.149563324791508 0.637472467068447 0.875105227838859 0.418475744458224 0.212992588032597 0.585771228040678 -0.392529041687702 0.530443864631137 -0.793053527375418 0.134467029458025 -1.18558256906312 0.046091511575911 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM219B 0.114161572381339 0.637612765599117 0.875184032656718 -0.249212451847197 0.329053330196792 0.677903342465487 0.8263654490141942 1.0 0.088172309637498 0.90640223037438 -0.46405353662154 0.341582776399734 -0.375881226984042 0.508226089606673 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP3K21 -0.290651015013569 0.63804984529872 0.875399085172193 -0.506789405428025 0.397348507975778 0.728024800638387 -0.735876266368598 0.33083582876674 0.561383475552225 0.357402198448824 -0.174492790816374 0.811006505330919 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP11C -0.0834098364049652 0.638101094855579 0.875399085172193 -0.0655696072411164 0.710237328007584 0.894621559692319 -0.913661005372509 0.0108059577780008 0.751049170682201 0.0205069211724562 -0.162611834690308 0.602807410313459 reversed False False False False False False False 0 insufficient_or_context_specific +RUNDC3B -0.322238701281459 0.638353440400963 0.875569091041943 -0.555061401254468 0.408833549206098 0.734801770489731 False False False False False False False 0 insufficient_or_context_specific +ZNF701 0.111383465064662 0.638415758711306 0.875569091041943 -0.0841611265124955 0.719545816848096 0.899654820203335 0.5287427490665549 1.0 False False False False False False False 0 insufficient_or_context_specific +SORBS2 -0.244317743846785 0.638728187289079 0.875645657708635 -0.406368493776375 0.434942578627374 0.75243712029294 0.203055418758938 0.747220160060829 2.0 -0.521531929094407 0.257083578986998 0.492766799144031 0.2082043134256 -0.0287651299503757 0.952580637156096 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C11ORF24 0.178178646567911 0.638842518307868 0.875645657708635 0.081301024268054 0.827062840022033 0.942259214105446 0.00364984006534475 1.0 True False False False False False False 0 insufficient_or_context_specific +CNTN1 -0.221876370623558 0.638961513362492 0.875645657708635 -0.216392918928219 0.647660164568009 0.86855377695836 0.317816083649539 1.0 False False False False False False False 0 insufficient_or_context_specific +TMEM51-AS1 -0.156971859757067 0.639210523641067 0.875769113659809 -0.418686623489486 0.185076579606278 0.56688091891009 False False False False False False False 0 insufficient_or_context_specific +TMCC1 0.0766737645785758 0.639389150346251 0.875800551291609 0.207407623995212 0.194887143621111 0.571343735852293 -0.174611578084044 0.538636281279204 -0.216485489318677 0.353774337200472 -0.391097067402721 0.115723737340941 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CAAP1 0.0722633325625723 0.639600187930562 0.875862358517623 -0.0321224463032924 0.834963362972251 0.946376318644998 0.677142029067241 1.0 -0.0748967650799514 0.829010029691934 -0.576257339201262 0.0320742930120582 -0.651154104281213 0.0279136606474788 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DANT2 -0.255103751305429 0.640109477304927 0.876292282169566 -0.104079633615593 0.84758464285327 0.952893503643581 False False False False False False False 0 insufficient_or_context_specific +AC008467.1 -0.159248012305794 0.640129091591588 0.876292282169566 0.247832702029149 0.480914768290424 0.780346070738476 False False False False False False False 0 insufficient_or_context_specific +APC -0.121394316216495 0.640297803139634 0.876292282169566 0.0889150938503636 0.734527977629799 0.904977889122883 0.433608042196105 1.0 0.0074488436720588 0.982553593752984 -0.152290531122471 0.514424870648078 -0.144841687450413 0.573324965024611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BRAT1 -0.155816360620159 0.640329130227145 0.876292282169566 -0.190085379808926 0.568795551683219 0.825363308778371 0.398773808195552 0.58581828116507 2.0 0.384953424433232 0.313054495114602 -0.396267247564074 0.209418698449 -0.0113138231308425 0.979881713598889 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LGR6 0.204533913766532 0.640504806025994 0.876312891019659 -0.193322035368084 0.622455415935894 0.855079408706246 0.388378302781015 1.0 False False False False False False False 0 insufficient_or_context_specific +CD44 -0.196397996542753 0.641002990352995 0.876732392547639 0.189761394697677 0.641504683693716 0.864815393882559 0.337714556654123 1.0 0.77589311276119 0.0692404679085664 -0.553423494619589 0.116115116528055 0.222469618141601 0.595356573835764 reversed False False False False False False False 0 insufficient_or_context_specific +ARMCX3 0.158595193101891 0.641537992073246 0.876825450322796 -0.0139240068833079 0.968165184261703 0.991065707083724 0.414108059667179 0.17261567806409 -0.104573944518983 0.69315329378422 0.309534115148196 0.27089579262501 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C22ORF34 0.264397623639462 0.641570168248537 0.876825450322796 -0.199581754111594 0.717068659487174 0.898001079656951 False False False False False False False 0 insufficient_or_context_specific +NOSIP -0.110351551710795 0.641642848465607 0.876825450322796 -0.150139772309538 0.523022343906148 0.803210168285253 0.407747596621687 1.0 -0.247741051296099 0.469009038090468 0.182224303594418 0.516655725454482 -0.0655167477016802 0.846227724613742 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF275 -0.176421231402939 0.641657860281522 0.876825450322796 -0.210927265733057 0.576881758138766 0.83036368131276 False False False False False False False 0 insufficient_or_context_specific +AC090518.1 0.127548930357443 0.641988631219739 0.876825450322796 -0.0626022672080403 0.81597520526219 0.936230700610385 False False False False False False False 0 insufficient_or_context_specific +GAA 0.161634182912449 0.64223208218065 0.876825450322796 0.118577154202205 0.731895040887298 0.904431845923655 0.586188410818188 1.0 -0.264947795340102 0.455356681556857 0.456600914836784 0.128761865609134 0.191653119496682 0.553007783403647 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KAT5 -0.108974337030103 0.642383089915606 0.876825450322796 -0.145476871582252 0.533080766958716 0.809783322169604 -0.125929446647139 0.695570341667619 -0.363803204844382 0.14891277864312 -0.489732651491521 0.0775680491080486 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MPRIP -0.110104380212373 0.642570108932332 0.876825450322796 -0.0252769937428284 0.915205059992934 0.974759629076879 0.613517728943072 0.113313772567943 2.0 0.0536690685040542 0.887455195909165 -0.469144453770772 0.0863916024007473 -0.415475385266717 0.137956546298075 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TIPIN -0.179337741007207 0.642652640644335 0.876825450322796 -0.262259506355501 0.496007369293803 0.78815141821466 0.437694515194449 0.317934656023734 -0.465766489315314 0.197877699633517 -0.028071974120865 0.953059229356595 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NAA15 -0.0800995761869866 0.642729615541593 0.876825450322796 0.0163477045848156 0.923043062899037 0.97777552504144 -0.0258597598168595 0.940685645135291 0.0267231749918878 0.92132853424592 0.0008634151750282 0.997836888554868 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC242426.2 -0.092543329094613 0.642773015787317 0.876825450322796 -0.0918076982647476 0.645065502204843 0.866709286367872 False False False False False False False 0 insufficient_or_context_specific +LIMCH1 -0.155930395243602 0.642783019541954 0.876825450322796 -0.283301074305136 0.395261926315615 0.726274872614038 -0.909150368047955 0.0636226328770745 0.291459135103582 0.490106334271544 -0.617691232944373 0.158624363002721 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM44 -0.166023969682293 0.642848542950117 0.876825450322796 -0.200745551216047 0.574084170958333 0.828936088208162 0.594352630329877 0.157559423611735 -0.879013201494075 0.0266934064077403 -0.284660571164198 0.487856877889904 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLPP -0.149148137138349 0.642867376245108 0.876825450322796 -0.289746271940046 0.346141132801093 0.691365508912966 -0.48490322091489 0.111435306598964 0.664175081181657 0.0228239405394811 0.179271860266767 0.528861368501011 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDIA6 -0.15673897104718 0.642889516310546 0.876825450322796 -0.0555182008714464 0.870332714152843 0.958502690861149 0.142808886623875 1.0 -0.450577302899284 0.213895021442475 0.333976350979243 0.295497737809961 -0.116600951920041 0.74927194226611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MED24 -0.0811042003232108 0.643075832179803 0.876825450322796 -0.190993559063214 0.285251175435629 0.646324118201271 -0.019635661276332 0.963608899578971 -0.287816332050942 0.32298057334693 -0.307451993327274 0.327991567446465 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNORC -0.197090794978874 0.643180641277931 0.876825450322796 -0.0277908595173359 0.951278500351282 0.986917609553614 0.0189348002268468 1.0 False False False False False False False 0 insufficient_or_context_specific +ARHGAP27 -0.24667751767373 0.643251101071972 0.876825450322796 -0.16072788633488 0.767194264719465 0.91954879692023 0.8271399887482691 1.0 1.51632656443178 0.0458694535434945 -1.4480899126808 0.0224617634025222 0.0682366517509861 0.941142242357347 reversed False False False False False False False 0 insufficient_or_context_specific +VXN -0.308946187692352 0.643364647384777 0.876825450322796 -0.692245847118707 0.283107349123899 0.644071250922027 0.038719648974471 1.0 False False False False False False False 0 insufficient_or_context_specific +SQSTM1 0.141301602306828 0.64348919559672 0.876825450322796 0.012116598017102 0.968984109222543 0.99145839504038 0.566984168420925 0.642640442171626 2.0 -0.52826787330272 0.150670160337765 0.985278310334719 0.0103561095005984 0.457010437031999 0.175695681230019 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SEC14L2 -0.256217389968897 0.643521028350562 0.876825450322796 -0.563335216302759 0.299483399501396 0.657713345206747 -0.618919577365014 0.196190190867017 0.71203458218152 0.100217708194134 0.0931150048165059 0.8531455864335 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MUT 0.114721224453402 0.643542376828125 0.876825450322796 0.0701368228718495 0.778817011844823 0.922929913000972 0.0386840132251356 1.0 True False False False False False False 0 insufficient_or_context_specific +NISCH -0.0966260682004131 0.64379071126191 0.87703825447833 -0.135646020465385 0.514400894693098 0.798565600083771 0.66591983400715 0.0106195325776663 2.0 -0.149306633772293 0.677860015872792 -0.336048343891449 0.233540589161769 -0.485354977663742 0.106277848470273 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TPM1 0.172187465829019 0.643931667876495 0.87703825447833 -0.370430741568031 0.304511351026033 0.661341495477036 0.205407618795657 0.312978202435792 0.145779337479086 3.0 1.42537352802388 0.004038132209842 -1.66438073436296 0.0020014802892984 -0.239007206339087 0.553397724125437 reversed False False False False False False False 0 insufficient_or_context_specific +FAAP20 -0.114574677718484 0.644045511182145 0.87703825447833 -0.0584462839265873 0.813985749925812 0.935357155824632 0.337656872128827 0.630636947805364 2.0 0.556107760344617 0.119477320176905 -0.345692876923688 0.245315963897729 0.210414883420929 0.542742702521988 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP002812.2 0.145883994166748 0.644101410208399 0.87703825447833 0.433465069484518 0.161409387784369 0.543541307772207 True False False False False False False 0 insufficient_or_context_specific +CFAP57 -0.379711771206653 0.644113906537694 0.87703825447833 -0.917190056217126 0.227359602800376 0.599516155436155 0.855149119781159 1.0 False False False False False False False 0 insufficient_or_context_specific +SKP2 -0.117189541828053 0.644528428114257 0.877489509223769 -0.0666580723735724 0.792397892591444 0.927620871373898 0.795952068398166 0.0771318970122348 -1.15085625963481 0.0099857138962666 -0.354904191236649 0.430346520651134 reversed False False False False False False False 0 insufficient_or_context_specific +PRPF18 -0.141522843094792 0.644744978373037 0.877637712179418 -0.483893675747327 0.074622309275554 0.452862231765951 0.0011080526988916 0.99714076360711 -0.0398561157448048 0.882263502119439 -0.0387480630459132 0.894652422072794 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIF3C -0.18974550663123 0.644859160574921 0.877637712179418 -0.272488610304027 0.503871324683995 0.792593954548845 0.342471806455476 0.417801644643761 -0.0602955989739247 0.875871155005697 0.282176207481552 0.458698542662427 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SFXN1 -0.0980484598642621 0.644969786777809 0.877637712179418 -0.0871380892913607 0.682019415356554 0.881689847843088 0.4026547058115821 1.0 -0.216641439810234 0.559578187358957 0.348003192273701 0.245848510199931 0.131361752463467 0.700198449876027 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SUSD1 -0.0966028375994606 0.645380890136506 0.878083948203767 -0.0432461762350357 0.837767954569955 0.9478289694297 0.369725413348318 1.0 0.259387368774147 0.731768744727329 -0.225581879476361 0.678709949119564 0.0338054892977855 0.963606419914876 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAPPC9 -0.0599738134636294 0.645579863771044 0.878181261125682 -0.0918840828366509 0.481694906862466 0.780666906162311 0.230211920556022 0.254889376890671 2.0 -0.159627324324364 0.561579206351713 0.0090741091537372 0.972168488880337 -0.150553215170627 0.535615332481901 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF122 0.149787510413926 0.645680836581901 0.878181261125682 -0.31591107367728 0.317415329855274 0.669290253214092 -0.352305577498851 0.490217157562913 0.361397946514827 0.366873281626793 0.0090923690159766 0.986526193303362 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP5MG 0.104647047355061 0.645963968339287 0.878181261125682 0.226272458517339 0.323582926769239 0.673691919126913 True False False False False False False 0 insufficient_or_context_specific +ARHGAP17 -0.086901024302841 0.646009688906815 0.878181261125682 -0.0450475121508708 0.81055310072314 0.933438195229734 -0.102567424153166 0.781810193990744 -0.262713988307752 0.337318213560175 -0.365281412460918 0.210620375888528 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TIMM29 -0.173053091898489 0.6460586720537 0.878181261125682 -0.120154658643275 0.752745426170492 0.913156486629435 False False False False False False False 0 insufficient_or_context_specific +ZNF665 -0.165327053120967 0.646133754522645 0.878181261125682 -0.445120051982178 0.192379268528209 0.570885363891703 0.6663710088246839 1.0 False False False False False False False 0 insufficient_or_context_specific +LINC00685 -0.154662085470642 0.6463916406354 0.878181261125682 -0.016139810889479 0.962291665033851 0.989873931526713 False False False False False False False 0 insufficient_or_context_specific +EEA1 0.0763898588580623 0.646410434319115 0.878181261125682 0.257281832895747 0.11419333588544 0.4924007041452 0.0409523123633821 1.30254629816486 2.0 -0.415700105217924 0.190373025256741 0.058799935714914 0.84955618013884 -0.35690016950301 0.222055603968994 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SCGB2B2 0.113534194674829 0.646496679088398 0.878181261125682 -0.0200713552635963 0.93550999780889 0.981714106181567 False False False False False False False 0 insufficient_or_context_specific +TCHP 0.0787518531916406 0.646533713082963 0.878181261125682 -0.0668037007556409 0.688733475144135 0.884999569552245 0.395859841338466 1.0 -0.105478237136345 0.837991630610843 -1.09597686019994 0.0125838512571596 -1.20145509733629 0.0134040129416659 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTIF3 0.101700849622357 0.646643714745566 0.878200087835419 0.105342153679472 0.634922074242318 0.861847932958146 -0.591285816926795 0.048557728071282 0.524785830235813 0.0498672413336228 -0.066499986690982 0.823352800050451 reversed True False False False False False False 0 cross_species_direction_conflict +PPP4R3A -0.0616605148919334 0.646901161325112 0.878200087835419 -0.0122594758236397 0.928166064999083 0.979087152943213 0.433784348700806 0.191346521738403 -0.166672003833237 0.56186391710334 0.26711234486757 0.386597426035181 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF844 0.209153269290297 0.646942445260369 0.878200087835419 -0.195112524387002 0.658653196591507 0.871710320505013 False False False False False False False 0 insufficient_or_context_specific +EVI5 -0.0651194218564327 0.646963466867199 0.878200087835419 -0.0146474773629254 0.917624188320467 0.975930957742715 0.480625310987445 0.3764452629669529 2.0 -0.474817272699861 0.137495008606554 0.295800660199086 0.281700093551272 -0.179016612500775 0.553933620392347 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPDYE5 0.168957934805598 0.64737415166372 0.878480422510034 0.33001245175499 0.379313357823759 0.716345443770593 True False False False False False False 0 insufficient_or_context_specific +CDS2 0.0983201078541856 0.647518018854374 0.878480422510034 -0.0737176312725936 0.735885544809771 0.905764683303975 -0.156748003484598 0.546443183042633 0.357667348581392 0.0979350016209224 0.200919345096794 0.367214665450035 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STAG1 0.0846401761054178 0.647561333351101 0.878480422510034 0.163188086251595 0.370803043982314 0.709933692593666 0.731370724904776 1.0 -0.636396686631022 0.106827059896946 0.229216883696536 0.503640842094015 -0.407179802934486 0.255558963829515 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAAP100 -0.152301218700605 0.647586013297556 0.878480422510034 -0.200504568938236 0.547980364055445 0.816156774016399 0.9203657284350569 1.0 0.598929878699196 0.0629609329087514 -0.973228428304968 0.0049941280003883 -0.374298549605772 0.225752101414604 reversed False False False False False False False 0 insufficient_or_context_specific +SLC35D2 0.148816916879824 0.6476840829111 0.878500584195195 -0.0185184688112835 0.955401819793344 0.987410276805219 0.7576927851494419 1.0 0.0573944563361469 0.918157951904821 -0.650001659755781 0.0893657345670305 -0.592607203419634 0.1562622246596 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PAXBP1 0.0737299556372968 0.647860393900966 0.878544751154398 -0.116715100229028 0.458898347207146 0.768201799558117 0.0784816953106823 1.0 -0.114605175941521 0.758158147574253 -0.780201869830437 0.0162003156555855 -0.894807045771958 0.0126766940351296 partial_or_other False False False False False False False 0 insufficient_or_context_specific +S1PR3 -0.176391590868508 0.647964390728948 0.878544751154398 -0.411243760116806 0.288939898978281 0.648310091921223 0.9404270800158492 1.0 0.102078333335741 0.848726472302442 0.489110023803671 0.183665342211174 0.591188357139411 0.136144148488194 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RCBTB2 -0.0978662452837933 0.647966279336929 0.878544751154398 -0.125860213008148 0.554864102977292 0.819814244898102 0.190655055529926 0.445065225783041 -0.219260068415331 0.287320042842124 -0.0286050128854048 0.912999483623368 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DLGAP4 -0.0841645667819929 0.648134473263243 0.878659960029959 -0.0266263737808859 0.884098719967602 0.963081098449005 0.5247442710101939 0.355486385315928 2.0 -0.158183516832201 0.652995653915581 -0.391465658292543 0.163126405624398 -0.549649175124744 0.0712425366635218 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GGACT -0.180059435442946 0.648286824146457 0.878753664056785 -0.0871123537624786 0.826381582782786 0.941936594352229 -0.919806245444393 0.0594342351897168 1.29472983266433 0.0086777696870135 0.374923587219941 0.374764925097589 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF623 0.110641905221226 0.648668018425643 0.878956640411558 -0.0621047596783495 0.792784915481388 0.927620871373898 0.392895859246802 1.0 False False False False False False False 0 insufficient_or_context_specific +KCNC4 -0.189544451536997 0.648686317682029 0.878956640411558 0.0760534662684942 0.856964905649132 0.956835392749951 -0.337328020892381 0.812398629280227 0.51758795338415 0.569281043290897 0.180259932491769 0.87897964413699 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGAP29 0.0802251229648997 0.648891183489378 0.879121405784787 0.02393254007452 0.89098497110948 0.964822494869117 0.41278948450174 1.0 -0.315629552408038 0.192020764815904 0.108941937235882 0.618744978573252 -0.206687615172156 0.354280553118945 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CHUK 0.143682653140918 0.649005303375249 0.879163201569911 0.0605439029137819 0.848773379479678 0.953127856970211 0.320964951196833 1.0 -0.251905087053214 0.407801213061688 0.0375850704782574 0.900241012403475 -0.214320016574957 0.432221388445355 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HIF3A 0.310823630577454 0.6495174886518 0.879577786594361 -0.504136388066656 0.446071102967139 0.761088995657248 1.12534815538958 0.771427749993995 0.14330310092882 3.0 -0.864340537656606 0.284804058768873 0.437637759135445 0.52507830435609 -0.42670277852116 0.563979991906007 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADAMTSL3 -0.191520988439752 0.649589473388816 0.879577786594361 -0.0378655219391243 0.928169927625361 0.979087152943213 0.54490351678866 1.00378696100064 2.0 -0.46974871673835 0.532987920690583 -0.138854156218571 0.833206179521415 -0.608602872956921 0.356192641384385 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATIC -0.110388199356784 0.649817281516888 0.879577786594361 -0.155211370787112 0.520530602979311 0.801118945922776 0.415644894763694 0.248083775024392 -0.201662644058191 0.508128470436538 0.213982250705503 0.533967476570559 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP22 0.068554762945033 0.649905393050059 0.879577786594361 -0.0207310391545589 0.892902984976711 0.965661185556767 0.38852807463763 1.0 -0.221122204447738 0.463604061792904 0.261447818986387 0.285169850142996 0.0403256145386498 0.895634376801625 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DEDD -0.111901438034473 0.650015323589585 0.879577786594361 -0.39912939542638 0.0982763624114307 0.478125555523304 -0.0905753916313217 0.75273414479534 -0.256657458954816 0.230552786272591 -0.347232850586138 0.133300925387202 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM182 -0.144258882161418 0.650061135517692 0.879577786594361 0.056598608379616 0.860668038041917 0.957336862161347 False False False False False False False 0 insufficient_or_context_specific +AP4M1 -0.129277215494847 0.650370518829459 0.879673995626776 0.129619459279618 0.645898159361181 0.867386513169085 0.147130590647554 0.719931206645768 0.112776667062326 0.72168414104192 0.25990725770988 0.436590805670123 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDH13 0.174524457533051 0.650382194531409 0.879673995626776 0.500194075111104 0.192915150575871 0.570885363891703 True False False False False False False 0 insufficient_or_context_specific +KIAA0040 -0.164518793496948 0.650663176919197 0.87981674520821 -0.269212153597465 0.462050083205994 0.769126302007068 0.5066389932813521 0.8558149054552099 2.0 False False False False False False False 0 insufficient_or_context_specific +VPS13D 0.0590864666825265 0.65075101829773 0.87981674520821 0.0402389171343684 0.756828659463799 0.914454644719928 0.511912555948044 1.0 -0.159451542528874 0.52616888334608 -0.136173966968397 0.515303978941256 -0.295625509497271 0.175692437851053 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BEND6 0.255157590506016 0.650954521888868 0.87981674520821 0.63754604966245 0.289667062854325 0.649046020716462 True False False False False False False 0 insufficient_or_context_specific +SLC16A1 0.154017491946052 0.650987236229105 0.87981674520821 0.147359279878523 0.666409299991512 0.87511808324756 -0.0347690140041574 0.933540365474146 0.520121003127699 0.0658843925485911 0.485351989123542 0.101975987082887 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NFYB 0.176037885527957 0.651052096743344 0.87981674520821 -0.173455028083903 0.657018062734691 0.871684912617742 -0.0627783509300973 0.866575342302366 0.0290326005633627 0.923571415795912 -0.0337457503667347 0.917335477477782 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADIRF 0.17066265803713 0.651154361091262 0.87981674520821 0.228412709584496 0.552641180131544 0.819071644755648 True False False False False False False 0 insufficient_or_context_specific +ZNF821 0.105482007558564 0.651562513926974 0.880255537049391 0.0674906613320112 0.773647122701079 0.921597905470986 True False False False False False False 0 insufficient_or_context_specific +SCAPER 0.0738966198945894 0.651824951961757 0.880497421035342 0.179162276205986 0.266934367077755 0.630039362093388 0.7588263621490992 1.0 -0.192164986930258 0.752230520298477 0.244181657201315 0.57134695713164 0.0520166702710573 0.925857252371527 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SRGAP2C 0.113456653868104 0.651950859079355 0.880523379906644 0.393901017105416 0.109302420283302 0.485176912870447 True False False False False False False 0 insufficient_or_context_specific +PEAR1 -0.131254329927014 0.652108091258626 0.880541914248443 -0.454994091641718 0.0846593282066313 0.465302662671366 0.7426210689008119 1.0 -0.220188723268563 0.635086683540577 0.0629932481376911 0.88309189297269 -0.157195475130872 0.707817693821871 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFATC1 -0.214829089736212 0.65243629231927 0.88066344985361 -0.484368963021159 0.305195931320609 0.661383136880745 -0.433884342265694 0.275754707672059 -0.0078180304380827 0.985246837553658 -0.441702372703777 0.225752101414604 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AF064858.1 -0.250823174844804 0.652967405662261 0.881197457701684 -0.0521806712274142 0.924729861371533 0.978480541854262 False False False False False False False 0 insufficient_or_context_specific +GNAI3 0.0761515364823906 0.653088422978225 0.881197457701684 0.151050998624077 0.37966396280042 0.716424065042321 0.629897086803853 1.0 -0.0173295699278109 0.960760068523928 0.367168940398916 0.125518275619988 0.349839370471105 0.16765676831985 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC111000.4 0.290018086127545 0.654005450324401 0.882288405279749 0.504783994288001 0.440208324191648 0.756769095948255 True False False False False False False 0 insufficient_or_context_specific +PWRN3 0.229336166026512 0.654213683331468 0.882369451790194 0.543875342483581 0.29472390496146 0.652324662738756 True False False False False False False 0 insufficient_or_context_specific +LINC01169 0.241932777154137 0.654522679268063 0.88256072129147 0.56058118687971 0.291542426887231 0.650899755355335 True False False False False False False 0 insufficient_or_context_specific +BCAR3 -0.186152890481826 0.654803012628236 0.882667820129841 0.0020304745425477 0.996166185058189 0.998795540446485 0.643384174955787 1.0 -1.27001211155993 0.0150020259730402 0.962067713971714 0.0350141101923505 -0.307944397588213 0.479237939970672 reversed False False False False False False False 0 insufficient_or_context_specific +RAB29 0.122732632584262 0.655050235476451 0.882667820129841 -0.103368970610117 0.712503265930202 0.895497343705388 0.216745734490173 0.54197599541736 0.103771377692851 0.722006202011721 0.320517112183024 0.291542876548245 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB7A 0.0691238835403587 0.655053007212046 0.882667820129841 0.114452705678284 0.454584396679115 0.765893042233195 True False False False False False False 0 insufficient_or_context_specific +KPNA1 -0.0836543461429153 0.655068910577145 0.882667820129841 -0.0101572340811096 0.957140608463908 0.987656798648419 0.289132869434872 1.0 0.0139512350452277 0.97167108654619 0.347685612022534 0.185673805661246 0.361636847067761 0.205038910314473 partial_or_other False False False False False False False 0 insufficient_or_context_specific +METTL6 0.102508183718446 0.655350787319781 0.882667820129841 -0.0284966524852133 0.899049830191842 0.967837995533705 -0.0396131809276751 0.935047012014342 -0.813388864857573 0.0246079859153381 -0.853002045785248 0.0298248636211815 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDIP1 0.141118876588311 0.655351559687376 0.882667820129841 0.199428389387821 0.528562468388298 0.805883171925403 0.599146204330813 0.348409621283615 2.0 -0.617312803777136 0.0953819271801975 0.336745446605331 0.296556406587841 -0.280567357171805 0.409414986318457 reversed True False False False False False False 0 cross_species_direction_conflict +SNX1 -0.05891972168271 0.655394864622913 0.882667820129841 -0.0645363040648231 0.623318599696705 0.855452720082907 0.0448953585467496 1.0 -0.171118676514577 0.577904763167055 0.0453653223129093 0.869689358314265 -0.125753354201668 0.650530113292247 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF639 0.134743099419496 0.655476839198493 0.882667820129841 0.131929682701488 0.66275848333831 0.874019993390692 True False False False False False False 0 insufficient_or_context_specific +AC092903.2 0.200318073673258 0.655586631751962 0.882667820129841 -0.296162384775575 0.479985557511128 0.780162456875056 False False False False False False False 0 insufficient_or_context_specific +PPAT 0.156765524624287 0.655605327283407 0.882667820129841 0.405251589553208 0.259594482502198 0.622885940784012 -0.416024166631292 0.37679897285318 0.428682692693747 0.270345675256536 0.0126585260624545 0.980873751510795 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PANK1 -0.200572869039302 0.656262876150146 0.88333842521697 -0.524900462184072 0.235225247080825 0.604406950274847 0.441988617634776 0.464458610110714 2.0 -0.436998082195344 0.420616529890072 1.01635342148584 0.0392652135571389 0.579355339290494 0.224078614748809 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VPS51 -0.100743603591882 0.656270752737442 0.88333842521697 -0.0708405712723632 0.754278245035624 0.913618862571469 0.116493849260713 0.70501201336217 -0.601633538865697 0.0237409335799989 -0.485139689604984 0.0677144109380963 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UNK 0.0689217706851168 0.656391594441693 0.883359351774116 0.0880704049234528 0.568582983690676 0.825281707699499 0.5805209401400561 0.411332423103294 2.0 -0.0950574226683234 0.800580020027083 -0.596988068961206 0.0430815038154972 -0.692045491629529 0.0324500370569302 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SH3BP5 0.26003877470453 0.656453634591752 0.883359351774116 -0.0914670738078198 0.86997397982871 0.958502690861149 0.54470379199438 0.210815446659802 0.0305111604473725 3.0 -0.235557309554665 0.466144910163573 0.0819123413879438 0.776997266845696 -0.153644968166721 0.603712335519905 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FGD4 -0.13182824964043 0.656762459477016 0.883503625629006 -0.337375974558999 0.247507150681396 0.61299096807276 0.447237806828954 0.311962157970947 2.0 -0.0575554352212387 0.870792851726127 -0.0015242636285475 0.996195719194125 -0.0590796988497862 0.842531613813403 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POMGNT1 -0.155100754015965 0.657074751850325 0.883503625629006 -0.0150478924712834 0.965874743267305 0.990675792866759 0.127347922348131 0.746937945336783 -0.0995019172163082 0.743708668295424 0.0278460051318232 0.940431634814982 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CXCL2 -0.232651057703231 0.657075207166308 0.883503625629006 -0.0110065260492309 0.983448031209101 0.99451887511202 0.650790235022401 1.28571473259484 2.0 False False False False False False False 0 insufficient_or_context_specific +MICAL1 -0.193130040255529 0.65741580801859 0.883503625629006 -0.468852009668929 0.254616432528928 0.61983866604575 0.677367506570922 0.0677272887640014 -1.09890627111095 0.0057854606393944 -0.421538764540032 0.233677887854942 reversed False False False False False False False 0 insufficient_or_context_specific +JUND -0.234579745237829 0.657609562700804 0.883503625629006 -1.13189642180561 0.036131122406971 0.37720666979567 -0.409210199399113 0.179575895036348 -0.426596333937798 0.120135669877274 -0.835806533336912 0.0136652688720714 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARMC8 -0.0806913556219277 0.657613794316837 0.883503625629006 0.0390869843291426 0.831059001384877 0.943790632272401 -0.10083478910861 0.802388876152692 -0.174588210199387 0.551254717779774 -0.275422999307997 0.37608712774108 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01004 -0.0882985023778547 0.657694532331972 0.883503625629006 -0.146544238646929 0.46202268074732 0.769126302007068 False False False False False False False 0 insufficient_or_context_specific +GTF2F2 0.0901758841891818 0.657695066152682 0.883503625629006 0.181076113332211 0.370064215625593 0.709652000364538 -0.304136264394296 0.293843453845735 -0.198236014746708 0.429036387881565 -0.502372279141004 0.0699673784309596 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAPT -0.171328372710927 0.657857239281801 0.883503625629006 -0.268275006763734 0.491228631194198 0.785509848901139 -1.09243245983744 0.0518014637285524 0.710831391140702 0.143729320925375 -0.381601068696739 0.446811822139139 reversed False False False False False False False 0 insufficient_or_context_specific +DDX24 0.0990368564919473 0.657914281105862 0.883503625629006 -0.0179680709648034 0.933998888023303 0.981307618643649 -0.150283261896528 0.586880747018774 0.16823228059809 0.450451383861286 0.0179490187015616 0.947534261417549 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TIMM9 0.143644437735417 0.657941463848972 0.883503625629006 0.268654659671142 0.411964662824917 0.735291083225579 0.0185062677328227 1.0 -0.428749924372313 0.323926591728324 0.669776221265725 0.070598156938088 0.241026296893412 0.542990362101498 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF493 0.152256387152215 0.658068148737039 0.883503625629006 0.290868059579368 0.396303316054011 0.727175949061217 True False False False False False False 0 insufficient_or_context_specific +SBDS 0.1228173338024 0.658111939475062 0.883503625629006 -0.0046816869271688 0.986137851025384 0.995662563940518 0.226205477492552 0.722790319111753 2.0 -0.470107581887434 0.0515628428779546 0.729700429022745 0.0052774696002589 0.259592847135312 0.227366155210295 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EBLN3P -0.123676426411753 0.658128080272488 0.883503625629006 -0.0824990224102297 0.768131505042637 0.919690570309936 False False False False False False False 0 insufficient_or_context_specific +OBSL1 -0.137456807833872 0.65815078760865 0.883503625629006 -0.350301344970024 0.245236656799582 0.610669341516615 0.817067933495261 0.0095657345050797 -1.1710601485214 0.001541021056078 -0.353992215026136 0.191413802693045 reversed False False False False False False False 0 insufficient_or_context_specific +CTNND1 0.134511892862223 0.658265158988503 0.883544819298324 -0.0705828810399868 0.819218949249192 0.937594977362923 0.22390661643567 0.36307743967883 0.0307920456391835 0.900295200031608 0.254698662074853 0.250405462885105 partial_or_other False False False False False False False 0 insufficient_or_context_specific +THSD4-AS1 0.12956633719049 0.658737395734686 0.884065610628249 0.021139606335726 0.941067461341372 0.984111856389759 1.89456475763412 1.0 True False False False False False False 0 insufficient_or_context_specific +HSCB -0.119384749440293 0.658891745942611 0.884065610628249 -0.184103013411927 0.497295890628912 0.789146979692815 0.222963999816433 0.688936764998849 -0.0721494269117096 0.872919594955843 0.150814572904723 0.766813623813635 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MICAL3 -0.0832706415453321 0.658926370356167 0.884065610628249 -0.149893535374589 0.423566409018703 0.744839131648811 0.8824573138367992 0.12570459341447 2.0 -0.123314501811799 0.675693192702888 -0.488191444448835 0.0468400053622487 -0.611505946260635 0.0254654852501922 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC009119.2 0.151351026341904 0.659047971863219 0.884065610628249 -0.0462393575414953 0.895669008844876 0.96715797942752 False False False False False False False 0 insufficient_or_context_specific +TXNDC15 0.15129417432417 0.659091482088628 0.884065610628249 0.0661814133686851 0.84518070907247 0.951323872749162 -0.613906188891441 0.226463034894478 0.857229614583929 0.0639885421583248 0.243323425692488 0.615187851786999 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TLE1 -0.156950503506746 0.659155567992572 0.884065610628249 -0.607128017056243 0.051176899172989 0.40964799201548 0.175422729821564 0.958990087183754 2.0 -0.276166678559163 0.386146052737778 -0.0753951922591484 0.79643906194232 -0.351561870818312 0.219341886877339 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPS1 -0.131783905870113 0.659275036162734 0.884074651470612 -0.283268857298621 0.336921919212257 0.685057785656405 0.0710168543060664 0.837892906728401 0.0762172740520798 0.770759297963488 0.147234128358146 0.584361990067919 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCTD2 0.134231774613784 0.659329778905058 0.884074651470612 0.144575288673217 0.635608772003896 0.861898723009269 0.7997127093000258 0.9511417425702231 2.0 -0.147260067721623 0.578080489617992 -0.0734779123560233 0.745833628967577 -0.220737980077646 0.326488650447368 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FUS -0.0629143653404388 0.659518086627529 0.884148827905619 -0.0407253553768016 0.773282157906728 0.921557797185125 0.434481515521548 0.0845859319918133 -0.131981428680251 0.554374722086723 0.302500086841296 0.193335455277716 partial_or_other False False False False False False False 0 insufficient_or_context_specific +JRKL 0.157923339752101 0.65963006323597 0.884148827905619 -0.0605739248083786 0.863865994388097 0.958391272020028 0.444142869690317 0.229122321344364 -0.222644795038511 0.456011114788405 0.221498074651805 0.535186281360996 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM45A -0.0924231902785186 0.659664383879896 0.884148827905619 -0.0988588397906778 0.637111162004574 0.862387134415935 0.160192690074143 0.5934438481956 -0.23590344492566 0.308624631277282 -0.0757107548515171 0.79051040585562 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP4K4 -0.0711498648288192 0.660004521139243 0.884148827905619 0.0879848805419722 0.590150639305311 0.836996260242226 0.919173230392485 0.0038119192011812 -0.72343804796865 0.0097873514076932 0.195735182423835 0.439665464839222 reversed False False False False False False False 0 insufficient_or_context_specific +PHLDA1 -0.138043893693975 0.660037039245778 0.884148827905619 -0.675026760189879 0.0185522167175988 0.327267058068343 -0.959134661357897 0.19521659232482 0.899230058105168 0.171548362140436 -0.0599046032527288 0.940014706726618 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM202-AS1 0.153761988937323 0.66011079635913 0.884148827905619 0.433480420755379 0.216137245517782 0.587986868893775 True False False False False False False 0 insufficient_or_context_specific +TAPT1 0.0844162147796795 0.660138777266527 0.884148827905619 0.0874148977689182 0.648434905422074 0.86855377695836 0.0802148388671733 1.0 -0.210078044182719 0.620462039775105 0.34953811093472 0.286903647535095 0.139460066752001 0.71470892340272 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ACIN1 -0.0762905329898396 0.660551022291466 0.884533775592147 -0.239998227306513 0.150046856246183 0.533583468169136 0.453438646555725 0.139388531697056 -0.316442926522941 0.237251315227482 0.136995720032784 0.649846431519055 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC087294.1 0.181555023305942 0.660593750761894 0.884533775592147 0.194990676224339 0.638460069031486 0.863438120767827 True False False False False False False 0 insufficient_or_context_specific +AP1M1 -0.0961787270086114 0.660783395034027 0.884675511636984 -0.187701671654096 0.39407238223061 0.725857678225886 0.0600578197699823 0.872875230330571 -0.270755777211004 0.294664459322549 -0.210697957441022 0.45288480501305 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRKAR2B -0.204804510870215 0.66090284827529 0.884723249916383 -0.801797374669731 0.0813276190385591 0.461068439742811 0.702813367003619 0.136016524461816 0.0048779337011767 0.991044763696252 0.707691300704795 0.109569125016934 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPN21 -0.0693210849939439 0.661191618762989 0.884885424122149 -0.272395558061199 0.0669841427984062 0.436862290339161 0.424313863006708 0.140698625800217 -0.64976896974871 0.0204679031337643 -0.225455106742002 0.406141782995995 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL645568.1 0.115579899571414 0.661327001143827 0.88495443321629 -0.0060212620459997 0.981519292167163 0.99451887511202 False False False False False False False 0 insufficient_or_context_specific +ATL2 -0.0847101067200257 0.66149123988103 0.88495573644355 -0.106596805072969 0.580149065455926 0.832343230477465 0.264200469714195 0.0269184497045571 2.0 -0.33758177953606 0.44844746469326 0.683295574498509 0.071783647878473 0.34571379496245 0.372523556216188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RFNG -0.140974878110065 0.66149561204892 0.88495573644355 -0.0726326069591277 0.822091782244885 0.938808681069134 -0.278094162136035 0.381230277697333 0.0955997765381673 0.734209695398824 -0.182494385597868 0.534520348185343 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAPKAPK5 -0.0827085571034934 0.661982539583797 0.885382778429912 -0.0118792297498033 0.950206207276328 0.986917609553614 False False False False False False False 0 insufficient_or_context_specific +CERK -0.0988704375309733 0.662402475316562 0.88554106891984 -0.286050639234371 0.180729276833995 0.563538010872213 -0.217106073600629 0.515012932115044 -0.0267113925057983 0.931942990277106 -0.243817466106427 0.400117618628453 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AREL1 -0.0777989019775502 0.662450520015646 0.88554106891984 -0.135137260024644 0.443801169209743 0.75955541145266 0.409426530305532 0.265861481698689 -0.216381181495579 0.488223108176914 0.193045348809954 0.584722649441226 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLCO4A1 0.406224581690857 0.66254582436615 0.88554106891984 -0.379834725143298 0.653900564414658 0.870640572179488 0.383377404221362 0.426493084671289 2.0 -2.11032881750951 0.0522704609155081 1.07119382677183 0.267958618632156 -1.03913499073768 0.238287605328604 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF557 -0.109794886211895 0.662638793786347 0.88554106891984 -0.265676742500495 0.262692320408306 0.625672953773913 0.476002000347757 1.0 False False False False False False False 0 insufficient_or_context_specific +PELP1 0.130657076987959 0.662665995025419 0.88554106891984 -0.0090007515747486 0.976090574883458 0.992970766113577 -0.484432490025357 0.193010785431213 -0.225877373891724 0.493045756929981 -0.710309863917081 0.0527904389355648 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA2026 0.0708992241592167 0.662688007722642 0.88554106891984 0.142894118978521 0.369610044974147 0.709345639075664 True False False False False False False 0 insufficient_or_context_specific +CPOX -0.142132730909088 0.662894228581089 0.885576036356938 0.0479306714961533 0.877927552865799 0.961265342988232 -0.311499672706285 0.449823867490762 0.780904370554445 0.033065590055291 0.46940469784816 0.188758850947986 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATAT1 -0.120930754859899 0.663043335784951 0.885576036356938 -0.303916881681488 0.265202409722023 0.628085922351979 -0.464928673862956 0.114678416922186 -0.495871596217995 0.0688023906896068 -0.960800270080951 0.0067903396604959 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC17A3 -0.34312435335487 0.663124269278241 0.885576036356938 -0.0541205866044361 0.954197408139909 0.987397455174082 -1.52332759877191 0.0080446784768728 1.37423774515016 0.009776171573976 -0.149089853621753 0.761748754635797 reversed False False False False False False False 0 insufficient_or_context_specific +FBXO33 0.0783907762907522 0.663149495436815 0.885576036356938 0.0763061068507046 0.670949952317607 0.87672504479995 -1.2012511404958 0.108668572802626 0.565835431221438 0.384967669341229 -0.63541570927436 0.340033350930498 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NR1H2 -0.138430716619631 0.66323548593607 0.885576036356938 -0.512458701913834 0.0938864295559976 0.474056873865243 -0.461537086844985 0.0551186380283413 -0.267577051590265 0.200499925578732 -0.72911413843525 0.0081045874302336 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF114 0.0902474695314181 0.663408676481323 0.885576036356938 0.114814254943395 0.577712615339229 0.83075298180061 -0.0341581042074103 0.930447584450039 -0.149240850416383 0.567837002875239 -0.183398954623793 0.516503111686054 partial_or_other True False False False False False False 0 cross_species_direction_conflict +POLR1C 0.133115768698889 0.663469070617861 0.885576036356938 0.190675185329598 0.533815720182147 0.810472587529927 -0.355941435020328 0.268511291264226 0.0042122210712473 0.990015111142855 -0.351729213949081 0.231574769772191 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ELL -0.144076442479503 0.66401209134287 0.886065301504382 -0.116106151183454 0.727231319050268 0.903365569206837 0.33169649238422 2.43788345760535 0.172565120045343 3.0 -0.423025336200637 0.167687234800157 -0.207823092942843 0.443010312880798 -0.63084842914348 0.0398128070646809 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MFAP1 0.14011073825403 0.664041230879316 0.886065301504382 -0.264138296842258 0.388292844558914 0.72175983324877 0.652562651840674 1.0 False False False False False False False 0 insufficient_or_context_specific +CCDC7 0.0910660720242368 0.664087396363343 0.886065301504382 0.375331738355015 0.0612154398025003 0.429729131273137 True False False False False False False 0 insufficient_or_context_specific +TTI1 -0.0938317749990292 0.664194146583899 0.886095754312965 -0.132315890995634 0.537480124576427 0.812087893451657 0.126140777258714 0.840035263543365 0.285724846706547 0.477307079631389 0.411865623965261 0.366290580919471 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TYMP -0.158367980841978 0.664884482024683 0.886792617637267 -0.215752697212076 0.554141889352146 0.819760413027877 0.6741787039964521 0.329532617854734 2.0 False False False False False False False 0 insufficient_or_context_specific +C11ORF49 -0.094979720621595 0.665122980312441 0.886875077111672 -0.0249425836069324 0.908332011160511 0.971429112904874 False False False False False False False 0 insufficient_or_context_specific +CRADD 0.106053594443055 0.665332349792063 0.886875077111672 -0.0886020211954928 0.721401975914938 0.90084370619145 0.0940667000500273 1.0 -0.0711460272485937 0.858126111808387 -0.344679358645316 0.209409090409061 -0.415825385893909 0.162909566177969 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM131 0.0554726861431496 0.665412624130978 0.886875077111672 0.105826608893974 0.405740454290516 0.733444811508554 -0.0803155783187844 0.816494785310693 0.203613968915924 0.40622972799695 0.12329839059714 0.659175193896285 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C4ORF33 -0.158231378820524 0.665473725226863 0.886875077111672 -0.141425601912796 0.699977832206973 0.890099316991353 False False False False False False False 0 insufficient_or_context_specific +MORF4L1 0.0828591988905818 0.665536085221463 0.886875077111672 0.0654794249518762 0.732774681666175 0.904431845923655 -0.0202845135119629 0.965039629475732 0.0326388012795774 0.93029383911543 0.0123542877676145 0.97581128444569 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DPM1 0.111405212851993 0.665538223022153 0.886875077111672 -0.0725501312382261 0.780593905124194 0.924025573379424 -0.0709194323795582 0.818428310744 0.338319943829381 0.122165534096414 0.267400511449823 0.248721773802069 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C2ORF74 0.123704247086512 0.665592362507297 0.886875077111672 -0.0422256291486564 0.886374990947618 0.963486786206626 0.304926032716431 1.0 False False False False False False False 0 insufficient_or_context_specific +POC5 0.120658311557499 0.66576035603457 0.886875077111672 0.335732841422206 0.233530497358422 0.602697571243329 -0.0146871043732741 0.973990024535509 -0.618328583014781 0.058055025770816 -0.633015687388055 0.0727601763196182 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KDM5D -0.42938466469874 0.665870310311065 0.886875077111672 -0.885505608817402 0.366903585392371 0.70818428785606 0.04295389394543 0.925059466657728 -0.637824080948212 0.0510766723217112 -0.594870187002782 0.0820836779793497 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAZ -0.161356151558171 0.666085015436773 0.886998383812683 0.32043769384456 0.380424942887116 0.716671165026344 0.22540751174399 0.5660238188950351 2.0 0.11026934499361 0.753360560689306 -0.762907847924683 0.0138088049183473 -0.652638502931073 0.0328385135242499 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAV1 -0.230565847725701 0.666166070538348 0.886998383812683 -0.494606683150151 0.357769946397853 0.701288497271586 0.276709862415185 1.0 -1.27318800460884 0.0181389663940921 1.13353288800389 0.0209075526994442 -0.139655116604949 0.777636572475041 reversed False False False False False False False 0 insufficient_or_context_specific +TLDC1 -0.0965982172718456 0.666214925519471 0.886998383812683 0.199307975029427 0.401955525171468 0.73106743062194 False False False False False False False 0 insufficient_or_context_specific +MORN4 -0.147352673040829 0.666890441407432 0.887281875274811 -0.0298553029229641 0.930281045694906 0.980230553264121 False False False False False False False 0 insufficient_or_context_specific +EPC1 0.0908467414667672 0.667021402746571 0.887281875274811 0.171415711407023 0.417096530207765 0.738399003760837 0.433881463016806 1.0 -0.0225604441712681 0.956175172604972 -0.352217865590405 0.204406642130604 -0.374778309761673 0.200097280541583 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CNTNAP2 0.171062127989767 0.66702146477373 0.887281875274811 0.0989492021179205 0.804085769475788 0.931585378484075 True False False False False False False 0 insufficient_or_context_specific +ONECUT2 -0.226303494077279 0.667079763495932 0.887281875274811 0.0954555449680662 0.857621954814259 0.956914759994669 -0.597577964398894 0.154976650324939 0.65640842138056 0.0810656541066896 0.058830456981666 0.895385725123861 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DYSF -0.244955496394325 0.667195461296393 0.887281875274811 -0.523238421103923 0.353667139721331 0.697398977158885 0.327194934893526 0.8198927964839609 2.0 0.787515201037322 0.0632900611312057 -1.09468280168637 0.0097992744997656 -0.307167600649047 0.455723562876612 reversed False False False False False False False 0 insufficient_or_context_specific +RRP1B -0.110812564460989 0.667304983716865 0.887281875274811 -0.11615910406347 0.652048070624856 0.870221657142868 False False False False False False False 0 insufficient_or_context_specific +KIAA1217 -0.132660134322278 0.667330275198788 0.887281875274811 0.379534616911946 0.133634738808525 0.520597197172027 0.617593816544606 1.0 False False False False False False False 0 insufficient_or_context_specific +FBXL12 -0.0948531074767652 0.667352279935336 0.887281875274811 -0.0674178388992691 0.761478097520265 0.916100519182983 0.372277115591489 0.488639769089791 2.0 -0.21580748465089 0.424102597954659 -0.0788431132876334 0.744369478176443 -0.294650597938523 0.219640401185941 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NSMCE4A -0.133551780748 0.667477945991266 0.887337214023645 0.0402127128425684 0.895791693946275 0.96715797942752 -0.438702760611348 0.159126567854185 0.259678938305937 0.336238944439673 -0.179023822305411 0.544931979203416 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF418 0.154081866542734 0.667710380468708 0.887534457634222 -0.143853433191105 0.678586422593168 0.880161603161999 False False False False False False False 0 insufficient_or_context_specific +DIP2C 0.078388425824272 0.668145158081671 0.887667031483048 -0.0330112934425935 0.857739068813805 0.956914759994669 -0.35047665010083 0.195378723747717 -0.0616531600016559 0.809325666838262 -0.412129810102485 0.10628174684105 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL356056.2 0.175862969178638 0.668205294244028 0.887667031483048 0.369094316418982 0.367795546709161 0.708317354196916 True False False False False False False 0 insufficient_or_context_specific +MARC2 -0.0813852600468364 0.668230495001636 0.887667031483048 0.0290098945133748 0.87747027177305 0.96120582328805 1.66458058108973 1.0 -0.163811445931371 0.741563261282446 0.64297264232168 0.09815875781029 0.479161196390309 0.225970717950124 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATG7 0.067832407123546 0.668369089085423 0.887739444277757 0.0738804810736282 0.639575962797409 0.864573988534439 0.8426573566551391 1.0 -0.490509600399395 0.0785511789806757 0.332003822298069 0.169450531790744 -0.158505778101326 0.546321402235466 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NLRC5 -0.190673180036287 0.668713782755932 0.887981691092379 -0.206784972738097 0.642539620544874 0.865003712470557 -0.322830329603722 0.313475120962477 -0.553353588152574 0.0597810843878797 -0.876183917756296 0.0134401817564192 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IQCH-AS1 -0.113834150778178 0.668803789312995 0.887981691092379 0.211266399037079 0.422182785331822 0.744017000089029 False False False False False False False 0 insufficient_or_context_specific +DGKD -0.0964483198317429 0.669310954326386 0.888521880212043 -0.0659693687715249 0.770816168203099 0.920631444062254 0.0692298602280476 1.0 0.283735113708801 0.282201559087706 -0.468335411203583 0.0507843512509165 -0.184600297494783 0.453134209035417 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL35 0.100772595536624 0.669911767015175 0.889005585237081 0.376646480034132 0.121293098352869 0.503433670515718 0.3477213328880919 0.33378917747704 2.0 True False False False False False False 0 insufficient_or_context_specific +FERMT2 -0.117726243784822 0.670117039625822 0.889076577029863 -0.295057255189032 0.292413127476545 0.651509781962399 0.578602956024107 1.0 -0.212760925119388 0.538058611485946 0.205519861654417 0.471989846822806 -0.0072410634649716 0.984914814547429 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UGT2B4 -0.199699652581902 0.670353758558985 0.889158069197929 -0.449682428997769 0.33919460976526 0.686946959803023 False False False False False False False 0 insufficient_or_context_specific +FAT3 0.234373299302742 0.67036353767906 0.889158069197929 -0.531210364631508 0.323935451909334 0.673780634605742 0.7890769552744499 1.0 False False False False False False False 0 insufficient_or_context_specific +MAF 0.123545560590879 0.670580009636168 0.889333468375664 0.132580588011061 0.648659455513986 0.86855377695836 0.7634315754845821 0.272684491247393 2.0 -0.0630144630107344 0.885896209712577 0.0090980807536615 0.980396812482588 -0.0539163822570729 0.885169880040828 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRKCB -0.236352729967594 0.6712578669771 0.889562013247675 -0.200747688827884 0.719659726574719 0.899654820203335 1.21655095215289 0.145618043828569 -0.1518505392005 0.804140581308795 1.06470041295239 0.17394769299212 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COX18 0.159755840456646 0.671853162360431 0.890127454912966 -0.159793098020091 0.655015049312567 0.871217143498979 0.443625171099194 0.7679905454234921 2.0 0.395008571171467 0.314294055946924 0.185805573579199 0.546829058413648 0.580814144750666 0.105724642017808 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TP53INP1 -0.155216920412488 0.671939957492483 0.890130749210243 -0.288664548070611 0.436828234294888 0.754216271085107 False False False False False False False 0 insufficient_or_context_specific +AL158152.2 0.091453943540366 0.672044733152968 0.890157858816841 0.103216099334815 0.632114305380218 0.860473275161544 0.0542663934110679 1.0 True False False False False False False 0 insufficient_or_context_specific +SEL1L -0.0852338563166396 0.672193071340711 0.890242655195086 0.0862587858918127 0.673896815206279 0.877796958653688 -0.292037393992946 0.471119257261521 0.328321061131846 0.33098220422769 0.0362836671388996 0.929848883257229 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA0895L -0.131289982519871 0.672366942648347 0.890249583707204 -0.134910739594041 0.664107636707819 0.874384483010807 0.393793515667253 1.0 False False False False False False False 0 insufficient_or_context_specific +DNAH11 -0.240391428686378 0.672482539763326 0.89029099120015 -0.63002138334968 0.249267187168612 0.615185358140767 0.386846859369677 1.0 False False False False False False False 0 insufficient_or_context_specific +RPS7 0.111570401311569 0.672792344068189 0.890384828267001 0.296868668456082 0.254817305449492 0.619879203544451 True False False False False False False 0 insufficient_or_context_specific +FBXO8 0.107717679327634 0.672915498937723 0.890384828267001 0.330252226416673 0.212681418198374 0.585220331857814 -0.637419900722784 0.0385908394070961 0.439822856715864 0.09815875781029 -0.19759704400692 0.475912505267572 reversed True False False False False False False 0 cross_species_direction_conflict +DSTYK 0.0947304383838351 0.673042454068544 0.890384828267001 -0.0138370800243798 0.95072179712192 0.986917609553614 0.396672239275036 1.0 -0.312889140359517 0.285812233050116 -0.0878932400042288 0.744197192949411 -0.400782380363746 0.139389244002259 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CC2D1A -0.103603115558845 0.67306183652677 0.890384828267001 -0.04596000856331 0.852248861643126 0.95449702781671 -0.218687769499229 0.502483688940042 -0.40441786895539 0.136905929242045 -0.62310563845462 0.0428096094304808 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TYSND1 -0.142129617849724 0.6733358270443 0.890499315598781 0.0930876880972994 0.785242669101369 0.925705787798454 0.270669354677949 1.0 -0.559084096713583 0.0438016738619931 0.232436166201093 0.324028385324035 -0.32664793051249 0.188758850947986 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM200C -0.209060433444396 0.673527801452733 0.890558112428046 -0.248716962265464 0.616718042155899 0.852377155266655 False False False False False False False 0 insufficient_or_context_specific +TUSC3 -0.144292260733548 0.673929388529335 0.890865967709117 0.0955562801982177 0.77868855899618 0.922929913000972 -0.163341329414108 0.650159083586419 -0.0903193769310708 0.763276683201078 -0.253660706345179 0.39913529227632 partial_or_other False False False False False False False 0 insufficient_or_context_specific +L3MBTL4 -0.13293351547218 0.67420996292369 0.891125286498288 0.142761224048077 0.64926864632325 0.869246612356457 1.4433531839449 1.0 False False False False False False False 0 insufficient_or_context_specific +TSPAN12 0.146867208958904 0.674540950075479 0.891314260497737 0.115045854231775 0.743219040659329 0.909273715761109 -0.301538336543364 0.436748903286456 0.650611303857807 0.0545234235655494 0.349072967314443 0.301761940458863 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SEC23B 0.106290615208679 0.674677486400377 0.891314260497737 0.244881608511823 0.344327663804651 0.69073818751447 0.0372555885935324 1.0 -0.438651304976128 0.220180427729438 0.41083133109806 0.186174159954838 -0.0278199738780673 0.94192263216745 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CGAS -0.127250613591014 0.67473134258559 0.891314260497737 0.214012626033807 0.48860686162057 0.783522364062876 1.11855788611069 0.105385249647223 -1.89946097102421 0.0081640552974316 -0.780903084913525 0.3086420834545 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC027117.2 0.149623487937785 0.674737985515115 0.891314260497737 -0.352389370164157 0.277934636705609 0.641126042022682 False False False False False False False 0 insufficient_or_context_specific +ANKRD24 -0.220039536151489 0.674891970991457 0.891314260497737 -0.327694730586691 0.525709398336502 0.804676662787375 0.106221908475507 0.862121950436023 -0.739541055593517 0.0863588075678184 -0.63331914711801 0.189818162461471 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TM4SF5 -0.220910941077626 0.674943882617864 0.891314260497737 0.062300878348008 0.908096598207498 0.971404958566788 False False False False False False False 0 insufficient_or_context_specific +SMARCC1 -0.0603433807602183 0.67507433851293 0.891366831387751 8.87380200570606e-05 0.999522177857216 0.999711553033013 0.253290808628599 1.0 0.0421510914188381 0.896862615694988 -0.0950898456639885 0.677585067137296 -0.0529387542451504 0.843188603495081 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRP54 0.0730445295697937 0.675152543152855 0.891366831387751 0.130956299119036 0.44597310260439 0.761078302286169 0.0925617786589832 0.0633066902065595 2.0 True False False False False False False 0 insufficient_or_context_specific +FLAD1 0.200484392739218 0.675412863163894 0.891483801729042 0.0867444223700227 0.853698735496267 0.95526155065304 -0.514872024790077 0.0440096429631767 0.239644337544872 0.267585508255353 -0.275227687245205 0.227495938175649 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NSUN2 0.0750946130527152 0.675494451016512 0.891483801729042 -0.0030981865338364 0.986711133808185 0.995855051722311 -0.216263588480084 0.466697815872244 0.229869165519034 0.342551241210756 0.01360557703895 0.965120741953813 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF830 0.163554925168681 0.675696078273511 0.891638444495904 -0.154848277374841 0.696121141511947 0.888447116319334 False False False False False False False 0 insufficient_or_context_specific +PCYT1A -0.0974590669745268 0.675958518734495 0.891800481038973 -0.036836821150736 0.875223787445706 0.960395245514428 -0.0511856860663912 0.860499407994346 0.0576549120510892 0.791631921384899 0.0064692259846979 0.980873751510795 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHST12 -0.104144551622598 0.676034279458644 0.891800481038973 -0.179136954460713 0.468103584978181 0.772583012794147 0.433241967997209 1.0 0.190997594027912 0.686005367038125 0.164797210650507 0.652937186610457 0.355794804678419 0.356097511074662 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KMT2E-AS1 0.130852917935836 0.67616122067926 0.891800481038973 0.0283023332768526 0.927948863532512 0.979087152943213 0.181989332387348 1.0 True False False False False False False 0 insufficient_or_context_specific +GTF2H3 0.0878186347660026 0.676227072829402 0.891800481038973 -0.113086028747986 0.594845505189181 0.840409319388114 -0.124042194994588 0.803929871007107 0.643049791800983 0.0603635977290344 0.519007596806395 0.157760104772429 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASNSD1 -0.139142611440503 0.67624120583425 0.891800481038973 -0.134191318889705 0.687615938317305 0.884451344908836 0.114796339793724 0.777993416002732 0.258394427059439 0.371403244387564 0.373190766853164 0.236914157471334 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARRDC1-AS1 0.172937662174269 0.676463089464185 0.891981678351801 0.446109736376055 0.295557344157383 0.653096366599759 True False False False False False False 0 insufficient_or_context_specific +TCIM -0.191169393236306 0.677110244065161 0.892461217295681 0.11457898818474 0.794948871139929 0.928199704380062 0.176133094525407 0.624524124378528 0.0461194018923465 0.888307854837482 0.222252496417753 0.466532569593338 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MX1 -0.173331379614435 0.677167581041343 0.892461217295681 -0.101731615110183 0.807983867057765 0.932788199072101 False False False False False False False 0 insufficient_or_context_specific +SNF8 0.087179079076163 0.677535891580625 0.892461217295681 0.123907205607157 0.554732424176458 0.819814244898102 -0.238504613378686 0.347005225305427 -0.132780508125282 0.552086968962076 -0.371285121503968 0.112258527412614 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HMGN4 -0.161050304165861 0.677552051779233 0.892461217295681 -0.212779454346883 0.579231431820162 0.831827949124047 0.385918842087264 1.0 False False False False False False False 0 insufficient_or_context_specific +SMIM14 -0.0964021786554208 0.677607428149237 0.892461217295681 -0.0763370326106026 0.741145205932968 0.908406208990048 0.635269309772599 1.0 -0.0001588763082332 0.999592852268872 0.340018219440228 0.231785235316527 0.339859343131995 0.26115363878731 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF75D -0.0912521115644994 0.677982051448161 0.892461217295681 -0.190850583731149 0.373133739229034 0.711656305116691 False False False False False False False 0 insufficient_or_context_specific +EIF4EBP2 0.109298979275877 0.678010174647533 0.892461217295681 -0.242192167406612 0.356032579157707 0.699495346273692 0.198102676411149 0.5519967783527729 2.0 -0.530971226884272 0.0971174568710989 0.737187942349989 0.0197347407745324 0.206216715465717 0.488574273351361 reversed False False False False False False False 0 insufficient_or_context_specific +EEF2 0.0852731389242855 0.678186595607265 0.892543642597766 0.127743787195129 0.533053597885357 0.809783322169604 0.58257904670908 1.0 -0.337983132777449 0.407328235360787 0.0379828155571872 0.92601282544327 -0.300000317220262 0.411580036046107 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NBPF1 0.131145710246925 0.678241868210066 0.892543642597766 0.182466566340543 0.562761019972242 0.823739199898368 True False False False False False False 0 insufficient_or_context_specific +AL353653.1 0.209926494323628 0.678485129298707 0.892641245499782 0.197995461524421 0.695340250599689 0.887929652374397 True False False False False False False 0 insufficient_or_context_specific +ZBTB40 -0.0892292377908897 0.678730619824908 0.892846820514997 -0.0562255409349892 0.79420363676933 0.928063228447907 0.238521897406029 1.63416077845776 2.0 -0.180780090070019 0.525073663158882 0.113312182471256 0.632945520070843 -0.0674679075987635 0.804464118541942 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP5PD -0.128013953877419 0.67887134147453 0.892846820514997 -0.0514459850872867 0.869225210018678 0.958502690861149 0.608173154319303 0.415100217632591 2.0 False False False False False False False 0 insufficient_or_context_specific +ZNF41 -0.0828874120116171 0.678961672258506 0.892846820514997 -0.0542981865050334 0.786653245974358 0.926121604088118 False False False False False False False 0 insufficient_or_context_specific +B3GNT2 0.127433149471058 0.679072629175978 0.892846820514997 0.0778188947517752 0.799791885994025 0.929755328734014 0.0713395033125499 1.02448222844923 2.0 -0.200035375673498 0.442792925682187 0.430969440465132 0.0531054777687024 0.230934064791634 0.308657601760708 partial_or_other True False False False False False False 0 cross_species_direction_conflict +JARID2 0.0773343623066554 0.679211266636724 0.892846820514997 -0.166979724877895 0.359958269028558 0.702743831320045 0.778269320038731 0.651369458831416 2.0 -0.140978366216582 0.616569134632343 -0.32643165802304 0.148788614114982 -0.467410024239622 0.0617486376410165 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DOCK10 -0.157442350508051 0.679233345555641 0.892846820514997 0.0679512533078518 0.857727197392246 0.956914759994669 0.7424016195645541 1.0 0.492274562685562 0.172593300098147 -0.349955215028862 0.25307591132336 0.1423193476567 0.694164662882171 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCGF3 -0.0746437016486075 0.679394273640058 0.892947185496295 -0.0831612264583294 0.644478979177356 0.866251949351307 0.0335949562056739 0.922837797081261 -0.238725451504875 0.298123821774826 -0.205130495299201 0.411017550770227 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITPKC 0.136270936234933 0.679626959911561 0.893058228615959 -0.103562802887444 0.75731067480542 0.914454644719928 -0.450045778244458 0.252551934410784 -0.0659224451042055 0.862701091892559 -0.515968223348663 0.157176244147384 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNAP29 -0.0914639508291298 0.679647932082708 0.893058228615959 0.0058374911474619 0.979638484683752 0.993948022418898 -0.0974492490659567 0.840035263543365 0.443204758273633 0.174524730711384 0.345755509207676 0.326494087185307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RTN1 -0.206158061312006 0.680276791188554 0.89355092826185 -0.113377528567808 0.821868038525201 0.938795061208381 -0.477311773412643 0.428401791823768 0.752299479289224 0.126779427095633 0.274987705876581 0.61396664458685 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS25 0.0923087832007076 0.680539427154365 0.893717555876668 0.152534227431982 0.490197147341062 0.784761407373303 True False False False False False False 0 insufficient_or_context_specific +MCF2L -0.243537014622553 0.680572944615307 0.893717555876668 -0.574431360374701 0.31579481380794 0.668002877965535 False False False False False False False 0 insufficient_or_context_specific +HDAC3 -0.0687351110892178 0.680663334689526 0.893725094845419 0.137856292943411 0.387573060487124 0.721183710367123 -0.145274626344656 0.654324972589684 -0.0821065120937832 0.760575555362796 -0.227381138438439 0.399815234394131 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CSNK1E -0.0959043944675226 0.68103188225863 0.893986648375807 0.151699047611662 0.520476849551647 0.801118945922776 0.367566992913555 1.0 0.215748653063011 0.54197599541736 -0.21845757076438 0.450305439532251 -0.0027089177013693 0.99487898639334 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USPL1 -0.0749631543548772 0.681167007724095 0.89405286767168 -0.078531023644451 0.666266995195558 0.87511808324756 0.178483887753456 0.580906900835266 -0.482060097415844 0.0703518890503919 -0.303576209662388 0.276133792844999 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NHLRC2 -0.0867199339942061 0.681362795212524 0.89408754559456 0.0526265424893871 0.808716329097143 0.932859303825974 0.230983284484152 0.405064184698135 -0.17858843210827 0.444111781246765 0.0523948523758827 0.853509951786062 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C19ORF25 -0.0922946350279936 0.681941733917271 0.894320327061556 -0.151009830280068 0.498160206598264 0.789518614144207 False False False False False False False 0 insufficient_or_context_specific +CCPG1 -0.0861793635581382 0.681950919450153 0.894320327061556 -0.116643315100618 0.577179710535454 0.830623076419833 -0.328997966091 0.3535030480205 0.837029947219977 0.0146965476533192 0.508031981128977 0.112193110805307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DUSP1 -0.148736473715899 0.681964664990729 0.894320327061556 -0.22378490653393 0.53659710493583 0.812039125226546 0.4038347596232849 0.436678173099833 2.0 -0.599812764266783 0.181626715567711 0.715457572364475 0.0799291755944823 0.115644808097692 0.80051812542952 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CISD2 -0.141602453222846 0.681996605529405 0.894320327061556 0.342241974865367 0.337798792683923 0.685729600683881 0.600527239011574 0.0308801406887665 -0.23673993247942 0.299495439010444 0.363787306532154 0.146374062493685 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BRD3 -0.0783215086704148 0.682048425222547 0.894320327061556 -0.18565399338992 0.314535668449604 0.666840881022273 0.5656106000631079 0.7941328889885899 2.0 0.119223673811995 0.649885878746164 -0.314696222722038 0.129995494858142 -0.195472548910042 0.373879874807838 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPS8 0.0981435051524276 0.682245044322116 0.89438034791501 -0.010418936841085 0.965078634409194 0.990502597656486 False False False False False False False 0 insufficient_or_context_specific +SYNGR1 -0.113214212123932 0.682533248753044 0.894442426166824 -0.101616694556637 0.713837756317877 0.895839656627142 False False False False False False False 0 insufficient_or_context_specific +FAAH2 0.186579275085791 0.682713068025783 0.894525263367612 0.252094238294181 0.580607541960475 0.832684720469939 True False False False False False False 0 insufficient_or_context_specific +RPL21 0.153737638142759 0.6829201647135 0.894600457925645 0.0305638273404911 0.935120987377045 0.981623780880792 True False False False False False False 0 insufficient_or_context_specific +TMEM268 0.145793773832321 0.682939921470041 0.894600457925645 -0.0518047478401341 0.883326390099662 0.96288234502947 0.450411436927438 1.0 -0.142895934208847 0.779825758885875 -0.644198498464833 0.0972691525163327 -0.78709443267368 0.0724762013996636 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NLGN2 -0.0974592141362603 0.683390098122484 0.895079103830441 -0.187313461651709 0.428912385083684 0.748336221434264 0.939128442342781 0.0189351149599825 -1.06473109501119 0.0081130337395933 -0.125602652668409 0.741854073547932 reversed False False False False False False False 0 insufficient_or_context_specific +MCU 0.116337944381483 0.683551193670957 0.895179050208133 -0.217501733276949 0.469542598904024 0.773833242954571 0.0172501215184061 0.97186315053216 0.126954177667431 0.710277434781454 0.144204299185837 0.709753376323547 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HEY2 -0.144401363250651 0.68369493010045 0.895211003252438 -0.302563784850339 0.392329893611792 0.724495427319379 -0.728465575709392 0.108071538563661 -0.168235549049229 0.689867120792113 -0.896701124758621 0.046475522565274 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAB39 0.0599112178399725 0.683862250781949 0.895211003252438 0.18277364638433 0.199345009281091 0.575122356864606 -0.441233624722775 0.0644356815345982 0.324838562712459 0.120386068187004 -0.116395062010316 0.608119365637099 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EIF2A 0.0816482371451182 0.683882082328889 0.895211003252438 0.240407661664381 0.216041225809941 0.587986868893775 -0.0911846137391908 0.795647347683738 0.204678113722337 0.409703382569248 0.113493499983146 0.695882706837052 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SRPK2 -0.0606198503312444 0.684214746079813 0.895313185618242 0.120066536526321 0.420492939299476 0.742402082462185 0.494953623809337 1.0 0.750819095311486 0.0108029393775789 -0.641485573507705 0.0155960482390681 0.10933352180378 0.686771061374468 reversed False False False False False False False 0 insufficient_or_context_specific +PPP1R26-AS1 -0.164991233812618 0.684259886336191 0.895313185618242 -0.519454332543201 0.185772276812076 0.56775396895769 False False False False False False False 0 insufficient_or_context_specific +MTMR9 -0.0964788402794197 0.684437682579394 0.895340484781717 0.344070497412832 0.140553765426385 0.526401063874107 -0.0296339695175484 0.932558334579471 0.229920528549153 0.31027575967809 0.200286559031605 0.414439818851846 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MARCH9 -0.111040899727395 0.685072193907407 0.895504193299869 -0.0930126288731005 0.734891189710297 0.905154127503653 -0.436331383515125 0.54197599541736 -0.58641817213052 0.322285455025229 -1.02274955564564 0.117934511079421 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LBR 0.0826436820067474 0.685279860880415 0.895504193299869 -0.0176775120197837 0.931053361102552 0.980624704721547 0.527245539188079 0.417580969894747 2.0 0.620181330281938 0.0289429448518818 -0.390653683972595 0.0973048487417624 0.229527646309344 0.368495617422455 reversed False False False False False False False 0 insufficient_or_context_specific +PPP1R7 -0.0839837889770725 0.685321400910369 0.895504193299869 0.185945726344178 0.389262985766956 0.722218665388488 1.02059514879574 1.0 0.0695613325911005 0.874025036276111 0.395148148543759 0.177827168539159 0.464709481134859 0.147566065017657 partial_or_other False False False False False False False 0 insufficient_or_context_specific +THEM4 0.088856075150468 0.68532777861871 0.895504193299869 0.0464791108611902 0.83086921740626 0.943790632272401 -0.327050493319696 0.553409182338267 0.0243253657566889 0.961891143188189 -0.302725127563007 0.535186281360996 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SPATA5 -0.0790586455684784 0.685350935703067 0.895504193299869 0.142426135290194 0.439162203302157 0.756143924080916 3.213865116780119e-05 1.0 -0.0045802050208484 0.989165574768777 -0.816093245371967 0.0048295125384273 -0.820673450392816 0.007411374517225 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GOSR1 -0.065548766772969 0.685389536785465 0.895504193299869 -0.151390969738499 0.341587450117376 0.689048585850067 -0.181072026826682 0.576518515629745 0.0382497952828681 0.899390109844151 -0.142822231543814 0.622224972509088 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TNS2 -0.0824159976387421 0.68541121447972 0.895504193299869 -0.205267865238581 0.296804403797068 0.654889895570548 0.5280611089442779 1.0 -0.211704272942442 0.543886745385232 0.338948886857982 0.236021134057678 0.12724461391554 0.693444863794893 partial_or_other False False False False False False False 0 insufficient_or_context_specific +YWHAQ -0.0680744691028795 0.685503876878011 0.895504193299869 0.0402356074366915 0.806462735680064 0.932788199072101 0.304512609424245 0.58160692122352 0.153087359202025 0.717973438004204 0.457599968626271 0.322958990591 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBXN6 0.0916906528982884 0.685583165854718 0.895504193299869 -0.106863952979256 0.640672418485562 0.864640237429136 -0.157828747286226 0.647352963989451 0.240991279170284 0.368127324670613 0.0831625318840577 0.792871789850276 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DSCAML1 0.140764635242449 0.685625950120042 0.895504193299869 -0.119722833660717 0.732298910502217 0.904431845923655 False False False False False False False 0 insufficient_or_context_specific +BCL2L2-PABPN1 -0.0839887901856432 0.685795954562761 0.895504193299869 0.085826245173248 0.685087527089517 0.883169000123458 False False False False False False False 0 insufficient_or_context_specific +TBL1Y 0.432427114636936 0.685825177574877 0.895504193299869 -0.359542868140513 0.725521291246604 0.903230533056069 False False False False False False False 0 insufficient_or_context_specific +PRR13 0.16429392318213 0.685939706672204 0.895530038709673 -0.116752629876772 0.770444829265135 0.920631444062254 -0.375283390949309 0.410027301825488 -0.104865250369873 0.800206198655932 -0.480148641319181 0.236710387195145 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FP700111.1 0.162600137047582 0.686249499369436 0.895645012903589 0.324400743666958 0.417106616634745 0.738399003760837 True False False False False False False 0 insufficient_or_context_specific +AL445472.1 -0.116461686637102 0.686294376155871 0.895645012903589 0.256072169809296 0.366534480123038 0.707896919588155 False False False False False False False 0 insufficient_or_context_specific +AC090630.1 0.113857208498882 0.686307671458182 0.895645012903589 0.366133783260545 0.193532879509464 0.570885363891703 True False False False False False False 0 insufficient_or_context_specific +AC104035.1 0.268988167012376 0.68638597973332 0.895645012903589 0.175622013487294 0.789756540830515 0.927193323483662 True False False False False False False 0 insufficient_or_context_specific +SPAAR -0.196599696587685 0.686556598508337 0.895645012903589 0.128283095892451 0.795950291220173 0.928784612588703 -0.303777204556079 0.648190823241092 0.899862782697718 0.0613489567065768 0.596085578141639 0.245040130549481 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SULT1A2 0.24797255227419 0.6866215887897 0.895645012903589 -0.0872850524369216 0.89016530131649 0.964713393362605 False False False False False False False 0 insufficient_or_context_specific +SEC14L1 0.0932995835227246 0.68691895688934 0.895922217027504 -0.0378975427686547 0.871038396588921 0.958683313195135 0.512684859659034 0.424290074107225 2.0 0.339937305801 0.307932377756419 -0.463186205295757 0.109524939983903 -0.123248899494757 0.70983486516815 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CATSPERE -0.107418205980834 0.687419078876704 0.896452110684994 0.469828714446898 0.0803380844133158 0.460352677246087 False False False False False False False 0 insufficient_or_context_specific +SLC1A7 -0.189731250573059 0.687495050219398 0.896452110684994 -0.25740839589642 0.58200281377641 0.833470017167205 1.63603313634596 0.5966260940743531 2.0 -1.00452237924496 0.259606060840288 -0.203527292791195 0.818750043709695 -1.20804967203616 0.152524682465516 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NRBP1 -0.0796901198213197 0.687609694258912 0.896490880709508 -0.199045786389247 0.295416553209839 0.653036159190561 -0.132805301891656 0.630990510411184 -0.220690409982067 0.312220000147468 -0.353495711873722 0.13264522111105 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MON2 0.0534466123311478 0.688031767187955 0.896930410911276 0.127987046254601 0.334144112959297 0.683965402214861 0.165150034881062 1.0 -0.0407696334516066 0.896467295186595 -0.341766872493858 0.118459267367523 -0.382536505945465 0.100553067827497 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NT5C -0.135237250368997 0.688133047971267 0.896951693886499 0.541909417205715 0.123876881563731 0.505954396731092 -0.331358184326531 0.297518775334364 0.589936681825816 0.0398883651237372 0.258578497499285 0.364011360670613 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE4A -0.0606842462063654 0.688463521030337 0.897082422402921 -0.0666167763811444 0.659145979138235 0.871978855750092 -0.0341956697949158 0.914827918728458 0.313744987474745 0.139207006469213 0.279549317679829 0.211830237885332 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBXO25 0.0799955457566339 0.688493564358949 0.897082422402921 -0.0450776698612666 0.81683718677362 0.936371599889798 0.279317289547888 1.0 0.105627309466329 0.836933962693437 -0.541219231603056 0.131381226562512 -0.435591922136727 0.266176955398821 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BCL10 0.188221606284518 0.688518095924985 0.897082422402921 -0.425893902706052 0.335100299827183 0.684461073909613 0.564253731179174 1.0 0.50653607063464 0.282589367960494 -0.158205197720507 0.677633129657597 0.348330872914133 0.425934629632173 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PSMD1 -0.0802851023144576 0.688853243367092 0.89722582574263 0.161151925679023 0.416805143146468 0.738236655148533 0.158143519266138 0.526946441920026 0.134759789855717 0.508982574672744 0.292903309121854 0.174898167856553 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APBB1 -0.134097352350048 0.68895516749772 0.897247891752921 -0.525278011901625 0.103263389752292 0.47952541118609 -0.668856048372315 0.213895021442475 -0.0776114010843258 0.886617519108884 -0.746467449456641 0.139291706914172 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPN2 0.0947190754973566 0.689628780625946 0.897610409140063 0.31478091138096 0.22115184902992 0.592913326464062 0.017735841258122 1.0 -0.0149596021949022 0.973683121458406 0.0503845745086964 0.883978117057987 0.0354249723137941 0.927489221408977 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DCBLD2 0.0745495026935385 0.689663335722207 0.897610409140063 0.138191373502001 0.458843414495355 0.768201799558117 0.382436398691517 1.0 -0.0810761271848226 0.859287605993411 0.0152640308122123 0.967568471469058 -0.0658120963726103 0.86558148122306 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SAMD1 -0.146302612711069 0.689865552964931 0.897610409140063 0.043002392955192 0.906172128093909 0.970714826340858 0.432807978111504 1.0 0.031009639097256 0.941370940333227 -0.136136730812424 0.636022245028813 -0.105127091715168 0.752267014939348 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AFF3 -0.136887876253644 0.689979913344468 0.897610409140063 -0.186478883665605 0.585895689078793 0.83502769041167 0.661757761137868 0.117083580617031 -0.137079669614316 0.690287431162989 0.524678091523552 0.183128207011902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NPEPL1 -0.128290623716589 0.689998681623485 0.897610409140063 0.262296912383069 0.409231620302522 0.734857324041122 -0.353492151824789 0.124912922699004 -0.215834036189828 0.286903647535095 -0.569326188014617 0.0201731410155041 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XPO5 -0.0811485809903713 0.690192842917923 0.897752375942766 0.0585143247173425 0.77130113857798 0.920641521976153 0.4570404648346861 1.0 -0.0044918303109911 0.993350829002914 -0.231678453481081 0.487420692985437 -0.236170283792072 0.526065349896183 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTF2 -0.0680713751415623 0.690283826335603 0.897760118064954 -0.0285410387684878 0.866766944524646 0.958391272020028 0.333943815255976 0.278153297623554 -0.521882382207142 0.0539566720986962 -0.187938566951166 0.530152309605016 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BTBD9 0.0788798070242811 0.690597180702096 0.897801418588806 0.200132088200876 0.307762275015687 0.662243470533128 0.297673296864315 1.0 -0.0445022690160339 0.92270626612151 -0.529011477246121 0.0933333850909758 -0.573513746262155 0.0932422102479162 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IMPA2 -0.109985333976217 0.690786657534172 0.897801418588806 -0.0203611205769879 0.940744988094109 0.984054846799435 0.0175177248004048 0.978513879659679 -0.322706668614797 0.430116272723707 -0.305188943814392 0.531796586632714 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FZD4 0.158498287670798 0.691142687215575 0.897992184546153 0.114163856893569 0.774643607194156 0.921907331897703 0.6030623883849201 1.0 -0.309995506601513 0.198871127019193 0.58597717580888 0.0148266528868059 0.275981669207367 0.210823513336526 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MT1M -0.218580792128634 0.691303828052056 0.898091031939659 -0.62112453247783 0.245112834643587 0.610669341516615 False False False False False False False 0 insufficient_or_context_specific +DYRK1A 0.0769534529826306 0.691394233292658 0.898097971838569 0.255181593084257 0.166367486841261 0.54636104500949 0.5828567702112061 1.0 -0.293634899424651 0.320743022442946 0.433811219092017 0.0889977295051248 0.140176319667366 0.614720999917199 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZC3HAV1 0.0802251463206748 0.691648759260781 0.898132119068903 0.154746384426887 0.443202945083649 0.759139632412907 0.267924048818103 1.0 -0.136024259396759 0.719214521019672 -0.0387824878102694 0.908885884946928 -0.174806747207029 0.585605216551667 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF219 -0.1535347585933 0.691689950885687 0.898132119068903 0.399194048980397 0.307348243231167 0.661701213710167 False False False False False False False 0 insufficient_or_context_specific +DUSP10 -0.144041353690019 0.691823981457943 0.898132119068903 -0.622212111016671 0.0818503839680408 0.461990123942529 0.452602832949066 0.217067306733729 -0.150008201462288 0.64929371433885 0.302594631486779 0.373406397510707 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALKBH5 0.112463745577139 0.691845853796874 0.898132119068903 0.10041534626953 0.722885108786751 0.901727431305591 0.42736930696099 0.266540930383494 2.0 -0.207498881610617 0.47982538411702 0.564990248081772 0.0320352186128655 0.357491366471155 0.162462787785814 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPL23A -0.15377578189252 0.692090425050345 0.89833915757088 0.0180730907823143 0.963157652984773 0.989935386867005 0.3511924870785491 1.0 False False False False False False False 0 insufficient_or_context_specific +ZNF24 0.0855483617452462 0.692329673393325 0.898427828802679 -0.0606105457913266 0.776512356260225 0.922725656431678 False False False False False False False 0 insufficient_or_context_specific +GDPD3 -0.169956342080458 0.692657344433108 0.898427828802679 -0.204824876526063 0.63383600610825 0.861821062780542 -0.167666308254037 0.81310596327621 -1.15578901438897 0.0436740191504614 -1.32345532264301 0.0390584644465845 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRP6 -0.0743645323207563 0.692694809728297 0.898427828802679 -0.0039906000804417 0.982971983775244 0.99451887511202 0.302250151657238 0.209483916909758 -0.183966565240134 0.384467549534515 0.118283586417105 0.61270833472551 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHB2 0.10128599896738 0.692848456125284 0.898427828802679 0.119597950130827 0.641684090890387 0.864815393882559 -0.243793920065604 0.595763570980941 0.564430308027474 0.126935750829864 0.320636387961869 0.406977123956987 partial_or_other True False False False False False False 0 cross_species_direction_conflict +VPS16 -0.110179809943364 0.692865037019999 0.898427828802679 -0.199885619150633 0.477061695601997 0.778367699299318 0.5876654943187499 1.0 -0.212430085783219 0.488522479960615 -0.149343150430996 0.562092981692175 -0.361773236214215 0.180112279737544 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM9 -0.137629073481488 0.692871654524891 0.898427828802679 -0.0435937172042208 0.901490827331583 0.968514302139562 0.0674716311002558 0.834983959905929 0.0001570073991883 0.999444943414147 0.0676286384994442 0.801598103376811 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEC23IP 0.0688197572995429 0.692924588931636 0.898427828802679 0.0777220269475435 0.654836946795922 0.871217143498979 0.338506238799249 0.324268194128397 2.0 -0.0387445187918613 0.914827918728458 -0.0811419280321774 0.750385572514452 -0.119886446824039 0.661437974853619 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CDR2 -0.065896054788206 0.693090904070077 0.898528445200253 -0.116828127425219 0.483553650852524 0.780666906162311 0.586065725478548 1.0 0.317879886837241 0.526280348137406 -0.464168765415627 0.230498379965613 -0.146288878578386 0.767164124367658 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LATS2 0.0695283751088795 0.693207240110609 0.898528445200253 -0.174511236355748 0.325437892533909 0.674724889947951 1.13619126345409 1.0 0.0253327917448488 0.944222686843845 0.109619627416304 0.667343290293859 0.134952419161152 0.616827189672714 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PWP1 0.105003252678097 0.693424885623073 0.898528445200253 0.304901310426082 0.273950315579773 0.637623822254105 -0.280977514511003 0.494420209461215 0.0635404340255332 0.864209712471647 -0.21743708048547 0.556951636963413 partial_or_other True False False False False False False 0 cross_species_direction_conflict +OLFML3 -0.214727374134042 0.6936895694193 0.898528445200253 -0.124869570211613 0.819643385338526 0.937645994477492 0.168790796250649 1.0 False False False False False False False 0 insufficient_or_context_specific +ARL17A 0.186095722424635 0.693778489760612 0.898528445200253 0.873153295198348 0.0763064643851786 0.455668688469891 0.065532964432784 1.0 True False False False False False False 0 insufficient_or_context_specific +AP000446.1 0.132250782982616 0.69378560359185 0.898528445200253 -0.251517900272655 0.450842467793927 0.763947905803589 False False False False False False False 0 insufficient_or_context_specific +NIT1 -0.110366855211522 0.693808761955624 0.898528445200253 -0.194259439477586 0.479372389965717 0.779968206697186 0.3765126161865421 1.0 -0.329249434114732 0.33302752695548 0.359741034276523 0.215132114811457 0.0304916001617912 0.931985800935355 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DHRS4L2 0.126533350437034 0.694076745681466 0.898528445200253 0.181534945146367 0.575888344250036 0.829928048970172 True False False False False False False 0 insufficient_or_context_specific +AL365275.1 0.176094685816714 0.694145202942938 0.898528445200253 0.468380890518392 0.29501068622892 0.652548722847306 True False False False False False False 0 insufficient_or_context_specific +ACP6 0.148035235519412 0.694197312765365 0.898528445200253 0.116879554160087 0.755632125080533 0.914440101763119 0.3364494942210349 1.0 -0.214578875679485 0.468839098744151 0.491171802240075 0.0533023742766094 0.27659292656059 0.279786045288159 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC00571 -0.133630994945111 0.694218905494395 0.898528445200253 0.204861512174439 0.550119508166277 0.817186218568941 False False False False False False False 0 insufficient_or_context_specific +CEBPZOS 0.0853570694282748 0.694233934701634 0.898528445200253 0.308275817144253 0.145508427927058 0.532658823056677 -0.2693346126054 0.61915330420746 0.44405313632983 0.283878281432221 0.17471852372443 0.717627569281498 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HDAC10 0.196609682236746 0.694258428006353 0.898528445200253 -0.20189800614323 0.683770590742456 0.88276472206638 0.30228627402099 1.0 -0.0808767414787251 0.813913635736174 -0.705645681391344 0.0145300686176159 -0.786522422870069 0.0137796810642469 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC007566.1 0.102480500687761 0.694329902372233 0.898528445200253 0.196289677692579 0.451456209500834 0.764202910889105 True False False False False False False 0 insufficient_or_context_specific +WIPI2 -0.0886523346078284 0.694334043099892 0.898528445200253 -0.197102928233679 0.378207931282805 0.715375612319217 -0.153708511794657 0.594410068765825 0.143891633791765 0.536409041578168 -0.0098168780028924 0.973742975257924 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GCNA -0.146222475797614 0.694613350935409 0.898635484338413 -0.011506047464548 0.975832446839036 0.992949014430083 False False False False False False False 0 insufficient_or_context_specific +C16ORF72 -0.0742835879856911 0.694616801258363 0.898635484338413 0.0377365526881562 0.844114394216425 0.950868579539813 0.7707768268914 1.0 False False False False False False False 0 insufficient_or_context_specific +AQR 0.0545693051093964 0.694831398673172 0.898744172332916 0.04495544510034 0.745789772914605 0.909628867935198 -0.0182234634806179 0.96557262501187 0.0285342490673668 0.93029383911543 0.0103107855867489 0.978510599027653 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RADIL 0.130011612632637 0.694871062583216 0.898744172332916 0.112915657272953 0.732089300054359 0.904431845923655 0.8291233179840091 1.0 True False False False False False False 0 insufficient_or_context_specific +SNHG9 -0.218382418669856 0.695105666403428 0.898832473206106 0.33213640183774 0.562173341231237 0.823449796992147 False False False False False False False 0 insufficient_or_context_specific +FBXO28 0.0708331371169462 0.695109598761873 0.898832473206106 -0.0795398129630691 0.658726886049596 0.871710320505013 -0.337722127986878 0.414569256421288 -0.154909848818822 0.670049273231752 -0.4926319768057 0.184591724323377 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FARSA -0.150082653771001 0.69544439360485 0.899078902778098 -0.375231060552418 0.322171027798863 0.672877524535327 0.289574969652258 1.0 -0.285835949522806 0.323627533839257 -0.0363421972847521 0.899903010515023 -0.322178146807558 0.22144388111188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TSNARE1 0.0905634667127711 0.695552000699203 0.899078902778098 0.0344246530815291 0.881467149045515 0.962618478946739 True False False False False False False 0 insufficient_or_context_specific +RPS29 -0.106993828177216 0.69555564291452 0.899078902778098 0.0906311137982421 0.742110882089071 0.909062152581089 1.39482541403954 1.0 False False False False False False False 0 insufficient_or_context_specific +PDXK 0.115618839514914 0.695875855807035 0.899354739017059 0.172527222577005 0.560213190193772 0.822518545691259 0.495660386947205 0.266481089303427 0.060365049937363 3.0 -0.318624196561323 0.336314896478139 0.455531786672986 0.105916919026318 0.136907590111664 0.665293704912991 partial_or_other True False False False False False False 0 cross_species_direction_conflict +APOL6 -0.0902155308570113 0.696007059110235 0.899354739017059 -0.0715371392705374 0.756056247236109 0.914440101763119 0.874789774682957 1.0 False False False False False False False 0 insufficient_or_context_specific +SRSF11 -0.0795605693319975 0.696107491280999 0.899354739017059 -0.169601329777627 0.397612186954467 0.728185510817911 0.0693455744771679 1.0 -0.1869256258062 0.58432243709334 -0.562146700755486 0.0558223668176447 -0.749072326561686 0.023257696200555 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NR1I2 -0.351919028184377 0.696109767687763 0.899354739017059 -0.635401320641123 0.471091279690663 0.774853050471104 -0.565240585142904 0.180410944822913 0.0258417401939506 0.952179584858255 -0.539398844948953 0.167723242600221 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VPS13A 0.0753341938335932 0.696340172105779 0.899357439294551 0.193557907267485 0.317350293968898 0.669290253214092 -0.201620143585196 0.445745076464153 -0.164900004867075 0.453590443867895 -0.366520148452271 0.123211512799421 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RNF115 0.0515356216971065 0.696365799940836 0.899357439294551 -0.0710030982244275 0.570646268039349 0.826426712486539 -0.0463797898496286 0.897741190240794 0.315284012826959 0.186181361436861 0.268904222977331 0.295614755790511 partial_or_other False False False False False False False 0 insufficient_or_context_specific +Z93930.2 -0.0994999565182152 0.696496128392143 0.899413664819501 -0.120529739335728 0.636133406645524 0.862000078223965 False False False False False False False 0 insufficient_or_context_specific +SLC35A5 -0.0847587649706302 0.696604586270081 0.899443710632202 -0.277412094314776 0.190708405674334 0.570066802692612 0.121268007190123 0.779058750287818 0.266306507724126 0.382863273634762 0.387574514914249 0.247431023668825 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MCFD2 0.125449664966924 0.696817699146304 0.899560095785663 0.11623120715237 0.718141666326966 0.898496799968868 0.6169913401686159 1.06680755717335 0.017425292427679 3.0 -0.30716839732627 0.403661175165371 0.828496120515323 0.0190078314334657 0.521327723189054 0.115436149968674 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ACOT12 -0.247438890084006 0.696865128190087 0.899560095785663 -0.379968956690681 0.547082887777251 0.815603096463177 -1.09218497324039 0.0297321086136799 0.940124468241733 0.0387035899534693 -0.152060504998652 0.747675530108488 reversed False False False False False False False 0 insufficient_or_context_specific +DTNBP1 -0.105105557488734 0.697358013106967 0.900039052803605 0.0248704755452739 0.926818342079268 0.979087152943213 0.45479243325397 0.704515646012187 2.0 -0.179273654929053 0.468203704418407 -0.215441691061037 0.295497737809961 -0.394715345990089 0.0794392339407848 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LPCAT1 -0.0962190869545358 0.697406657604309 0.900039052803605 -0.0273329953252846 0.91288136813987 0.973464340430836 0.593912512527277 0.0672462335464933 -0.436031208875711 0.109865425133823 0.157881303651566 0.619194764704666 reversed False False False False False False False 0 insufficient_or_context_specific +PIP5K1B -0.162699492462391 0.697561982638294 0.900077911257393 -0.0630030322058684 0.880323169799588 0.96227446663699 False False False False False False False 0 insufficient_or_context_specific +GPR180 0.080618865571338 0.697607269162649 0.900077911257393 0.102425706443306 0.622889811588782 0.855086546711008 -0.223289788160804 0.518591408009763 0.137185818867074 0.636739002791718 -0.0861039692937298 0.795142152891411 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRIM16 0.131633153766844 0.697867096175902 0.90022142213522 0.147166357014683 0.665292610763642 0.875081569913425 -0.629824474998085 0.415856830616875 -0.0557261013636443 0.940940065875699 -0.685550576361729 0.320654852970786 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SRR 0.0870772543418264 0.698093767990849 0.90022142213522 0.192360468814406 0.400465198303712 0.730369936723198 -0.0897613433362547 0.816326782498487 0.5146371196412 0.0672879620550469 0.424875776304945 0.145706272360995 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL603839.3 -0.11157655329714 0.69819101146978 0.90022142213522 -0.130401340047855 0.650545861471611 0.869901306439436 False False False False False False False 0 insufficient_or_context_specific +MTX3 -0.0917216630990047 0.698215426698246 0.90022142213522 0.185924530387594 0.460071982869992 0.768745132096508 0.007520614362118 0.987103209694911 -0.539706032053314 0.0810809258185391 -0.532185417691196 0.110845041418459 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBR2 0.0567242572935115 0.698267683770121 0.90022142213522 0.121962303651523 0.403282707189836 0.732213929838129 0.334729142022001 1.0 -0.409711893225281 0.107109858995624 0.0547498141470587 0.822511667978687 -0.354962079078222 0.133467274422914 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SRPRB -0.143031809284243 0.698315348293943 0.90022142213522 0.0193330314217038 0.957567906640054 0.987656798648419 -0.262255869984939 0.429116053506576 -0.208771786288484 0.454103994026797 -0.471027656273423 0.117376528985473 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP2A7 0.398693713264844 0.699076860949665 0.900824529747521 0.595778757463945 0.567410215391916 0.824849995454606 True False False False False False False 0 insufficient_or_context_specific +POGLUT1 0.0915624243794327 0.699172258014934 0.900824529747521 -0.0035415871932226 0.988088975115206 0.996679411413619 0.399100387999752 0.375278348615534 -0.377128256340648 0.299265004296928 0.0219721316591044 0.964336910007263 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AFG3L2 0.07961848790792 0.699295559893479 0.900824529747521 -0.0905111504619767 0.660397181602395 0.872407073022888 -0.132447268575604 0.612979727246638 -0.0398027491395799 0.867591304581815 -0.172250017715184 0.438020309617988 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC087386.1 -0.194267656317356 0.699325279647288 0.900824529747521 -0.225700544853114 0.653022105233628 0.870421334055882 False False False False False False False 0 insufficient_or_context_specific +NET1 -0.165394149756452 0.699380438562268 0.900824529747521 -0.21162827004461 0.619248487197735 0.853648649263425 0.383722837087145 0.33542535927571 -0.16591844345364 0.639367902883543 0.217804393633505 0.562317914898425 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DYNC1I1 -0.134925552737585 0.699601798092577 0.900889838304845 -0.0182877801328424 0.958239622519658 0.988093948096743 False False False False False False False 0 insufficient_or_context_specific +STRN 0.069416272890354 0.700360460522312 0.901539236705661 0.146446117514143 0.412046038621872 0.735291083225579 0.318732309485783 1.0 -0.0580417696019087 0.885471018366295 -0.0837713447928166 0.774791882855681 -0.141813114394725 0.651357841503356 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RC3H1 0.0500946623935544 0.700384296283065 0.901539236705661 -0.0206537707843073 0.87244916364966 0.959012833921199 0.432838871827382 1.0 -0.0308535813413587 0.911240264788933 0.0638291572007476 0.748359761018819 0.0329755758593889 0.885914643457236 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PKM 0.154510149317197 0.700515215487403 0.901539236705661 0.502520080974435 0.218264618539925 0.590550589518236 0.412071177880495 0.0394007687971603 2.0 -0.211042461258355 0.731556142006226 0.102849641350245 0.842695107521162 -0.10819281990811 0.847150174431023 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MPZL1 0.0821407186413564 0.700808209055233 0.901539236705661 0.185990998211011 0.380251360975357 0.716671165026344 -0.517472943636021 0.0988932747383366 0.29956889593354 0.271384794935438 -0.21790404770248 0.452237645846634 reversed True False False False False False False 0 cross_species_direction_conflict +RPS6KA5 -0.142138773736307 0.700831234108321 0.901539236705661 -0.300588273902847 0.412322878949212 0.735291083225579 False False False False False False False 0 insufficient_or_context_specific +AC112722.1 0.0943522521629501 0.700878302437256 0.901539236705661 0.0979096788676848 0.690766113344164 0.88580609997548 True False False False False False False 0 insufficient_or_context_specific +IFFO1 -0.111025311826258 0.701106844183024 0.901539236705661 0.153934529822411 0.588817608572585 0.8359199020182 0.384594863612115 1.0 -0.251838282978476 0.556892949729054 -0.637879768512389 0.080003819208415 -0.889718051490865 0.0301515177113284 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IRAK4 -0.068838585321015 0.701236305104682 0.901539236705661 -0.185622617697609 0.303908705364811 0.661341495477036 0.164487199544556 0.667979556006613 -0.106153565691374 0.725594259838567 0.0583336338531817 0.8741276256463 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OSBPL2 -0.0958543066616035 0.701286130622204 0.901539236705661 -0.0444434724388003 0.860026913959975 0.956914759994669 0.0320942791218559 0.949213952797514 -0.143109096691744 0.67750033111532 -0.111014817569888 0.780239983029481 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TXNDC9 -0.0941575174399802 0.701303840823519 0.901539236705661 -0.177368279217973 0.456241201818384 0.767060408474954 0.0548750995844555 0.846894988047948 0.268733012559968 0.173424661625072 0.323608112144424 0.126628974478663 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VPS39 0.0646718713741088 0.701396673724289 0.901539236705661 -0.0599181699428133 0.718550434765825 0.898549744197274 0.0664104892569713 0.895179480351654 -0.278518643696203 0.411444186573822 -0.212108154439231 0.582497480049863 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CEACAM1 -0.210009678728168 0.701449307490013 0.901539236705661 -0.354597494187485 0.511928438503957 0.797108298564159 -1.24615882422993 0.0121357494829551 1.69017864564106 0.0024339618187075 0.444019821411136 0.270775079115369 reversed False False False False False False False 0 insufficient_or_context_specific +CRTC3-AS1 0.152110901251877 0.701624040858266 0.901539236705661 0.647646183688527 0.125253563025723 0.507642816276301 0.412022668564839 0.0148398404292511 2.0 True False False False False False False 0 insufficient_or_context_specific +PIK3CD -0.141106097430797 0.701804898798805 0.901539236705661 -0.253713122744425 0.481387205135839 0.780599925022913 1.04520285735727 0.12655605970275 -1.18352441598661 0.0473274433055797 -0.138321558629335 0.858711457595346 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RELB -0.182548250422048 0.701881315766507 0.901539236705661 -0.0198387788536321 0.966968762773933 0.990805143378026 -0.712228612412302 0.162593505444905 -0.380179677138041 0.406329127296727 -1.09240828955034 0.0359623407133445 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GNA12 0.0749866393520783 0.70213008099794 0.901539236705661 0.157502735561955 0.424941550140009 0.745882731558725 1.15756711221788 1.1817613090273 2.0 -0.092266310122701 0.799286550120896 0.26393190931674 0.320339513549911 0.171665599194039 0.552752480757395 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DSP -0.129069164207615 0.702132505672295 0.901539236705661 -0.112078364540986 0.740259951405904 0.908274440555399 -0.384854057742984 0.470280936016029 0.181862619990841 0.694684607133917 -0.202991437752143 0.684454966428566 partial_or_other False False False False False False False 0 insufficient_or_context_specific +YPEL1 -0.173173589402764 0.702140983453313 0.901539236705661 -0.497867443001127 0.253799425391506 0.618991529980024 0.213727981102299 1.0 False False False False False False False 0 insufficient_or_context_specific +AC091551.1 0.134966133918161 0.702201388267133 0.901539236705661 0.0909915484460728 0.794365163429034 0.928063228447907 True False False False False False False 0 insufficient_or_context_specific +KIF13A -0.0892285782208682 0.702534446661638 0.901539236705661 0.119996503721333 0.590561445919067 0.837382184530421 0.735537642958246 1.0 -0.305672676085342 0.383151047751655 0.0408394063538497 0.904879342928437 -0.264833269731492 0.401209565852617 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C5ORF22 -0.0872311923075732 0.702582386779142 0.901539236705661 -0.104029976316481 0.648659422091785 0.86855377695836 False False False False False False False 0 insufficient_or_context_specific +MROH8 -0.113155428357219 0.70273757763307 0.901628793857085 -0.520863434852185 0.0789914759336272 0.458237364234745 False False False False False False False 0 insufficient_or_context_specific +ATG2A -0.132819161988251 0.703022753768784 0.901885083145908 -0.126935536442492 0.715934802808978 0.897511238192495 -0.288198125006348 0.321812793168779 -0.141027716901838 0.584889535573742 -0.429225841908186 0.11150728424137 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR1 -0.13007928277252 0.70332738864781 0.902166270118282 -0.195917669232655 0.56871817566857 0.825363308778371 0.209528901109662 1.0 0.360646095434752 0.175099670205399 -0.250773708419407 0.272504908851045 0.109872387015344 0.678208049807557 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WRNIP1 -0.0652338893601087 0.703633703035991 0.902288350204232 -0.073875303362459 0.665165347877934 0.875081569913425 -0.563606307996481 0.168608792821274 0.486691364733785 0.173522898353237 -0.0769149432626962 0.856838609757036 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GBF1 -0.0593387193437747 0.703674813479196 0.902288350204232 -0.0456936862783934 0.76927300541685 0.920253395046917 -0.473038811620347 0.0531973056968026 0.532622334425022 0.0220802570520064 0.0595835228046749 0.807499358841957 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMX4 -0.115286828144278 0.703678942563141 0.902288350204232 -0.267988855186966 0.363002636321835 0.704648250466249 -0.233932568521108 0.472624966029701 0.0193895373307979 0.950559403060548 -0.21454303119031 0.456342821466359 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM127 -0.125696032498851 0.703887084207843 0.902445638745162 -0.602430474311778 0.034839398004833 0.37720666979567 0.399372421968391 0.390107617488529 2.0 0.137791965030714 0.688936764998849 -0.105260367715547 0.702798397847325 0.0325315973151672 0.922454081084277 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EXOC6B 0.0793439649393913 0.704041679474383 0.902534246222746 0.214840094034886 0.291470111905487 0.650899755355335 0.253580814110632 1.0 -0.0583113758352063 0.911204635965993 -0.301997914435094 0.391187991711967 -0.3603092902703 0.33470763875269 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ABHD13 0.0903000095064879 0.704200986905806 0.902540802106569 0.216693210403468 0.359641317442217 0.702743831320045 -0.0215665240828264 0.971220331487005 -0.0214573473574107 0.964028491295299 -0.0430238714402371 0.933602644063331 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PUS7 -0.142161064298223 0.704217761673984 0.902540802106569 0.170595975164928 0.654327068568876 0.87095123423477 0.102039656058616 1.0 -0.426985919707445 0.351962483169755 -0.245708223029631 0.533436030151442 -0.672694142737076 0.118245127985827 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC009126.1 0.141111696513361 0.704502573044288 0.902667667589586 -0.314474275561718 0.403418112319416 0.732213929838129 False False False False False False False 0 insufficient_or_context_specific +HLA-C -0.144456758623479 0.704573238170655 0.902667667589586 -0.0356217781801639 0.928044659542697 0.979087152943213 False False False False False False False 0 insufficient_or_context_specific +ID1 -0.276202868214769 0.704894302156315 0.902846701052284 -0.814279571780218 0.236846533121158 0.605329180588419 -0.121321156609197 0.829010029691934 -0.125336054686541 0.770505482908639 -0.246657211295739 0.574360881866774 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADGRL1 -0.0967924106530088 0.705075355471614 0.902872723234603 -0.260114860577972 0.288529547028008 0.648310091921223 0.840111160942917 0.7972744485697909 2.0 0.277555056548905 0.313237442060416 -0.285895470704016 0.228034612710369 -0.0083404141551103 0.97898460014594 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SOAT1 -0.0641450820287255 0.705325737679712 0.903083814991803 -0.14832070157001 0.378915680830374 0.716066842028319 1.03663883013888 0.0875277122149622 -0.615234234547976 0.190161805947833 0.421404595590906 0.476696685177726 reversed False False False False False False False 0 insufficient_or_context_specific +RANBP3L 0.202568815302425 0.705806071286254 0.903370166158355 -0.756900359716551 0.17972824474144 0.562759923872656 0.539428951678214 1.0 False False False False False False False 0 insufficient_or_context_specific +CYP2A6 -0.334296803012194 0.706108836726506 0.903556693201319 0.183622897564057 0.840358204518557 0.948929978120132 False False False False False False False 0 insufficient_or_context_specific +PPP1CC 0.0884271237003327 0.706122966054564 0.903556693201319 0.334290101195785 0.133980425444796 0.520900171021663 0.431999167098871 1.0 True False False False False False False 0 insufficient_or_context_specific +MYH14 -0.219341587507091 0.706474181468646 0.903636202064089 -0.341083988572688 0.553506641559358 0.819509622995892 -0.703006602763898 0.109547386707045 0.0953098765292917 0.818004132344476 -0.607696726234606 0.134296667264054 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MROH1 -0.0861401538575375 0.706741815956419 0.903636202064089 -0.23604523285672 0.294538521049468 0.652324662738756 0.492263186779576 1.0 -0.17947389164466 0.580003247344219 -0.471088337952051 0.0814800799294036 -0.650562229596711 0.032830108802723 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AACS -0.101709585087591 0.706757575499958 0.903636202064089 -0.092344268613526 0.732484353785523 0.904431845923655 0.281295844779693 0.588698604296747 0.131914105066756 0.760595410708779 0.413209949846449 0.347515970519821 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF4E2 -0.0950272817029248 0.706932369644231 0.903636202064089 -0.228954070527591 0.357762413600877 0.701288497271586 -0.0863592528984942 0.791666364368641 0.0106873805792175 0.969912171137823 -0.0756718723192768 0.788407958430381 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRI 0.141317301183627 0.706967605493659 0.903636202064089 -0.0480425219355578 0.89877861502795 0.967837995533705 0.164659914275346 0.542043747850166 0.217884311587461 0.312913191660999 0.382544225862807 0.104569206472568 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF282 -0.0724558625303927 0.706986431430424 0.903636202064089 -0.277850384210022 0.155425896157535 0.539558215777 False False False False False False False 0 insufficient_or_context_specific +DLG3 -0.118906177917563 0.707199876254937 0.903636202064089 0.106730442380102 0.735987423571207 0.905764683303975 0.305188502311122 1.0 0.209841304393795 0.542930405994122 -0.1973025892658 0.465688765302306 0.0125387151279954 0.97254953638187 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TFAM 0.110592932447113 0.707495510524403 0.903636202064089 0.488159723352464 0.102470566225633 0.479137456027696 0.7729870533243031 1.0 -0.177022620185412 0.594630897541619 0.143077808715621 0.596324017777855 -0.0339448114697912 0.918249843470456 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CRTC2 -0.104212752922179 0.707602273542018 0.903636202064089 -0.116306983082192 0.675370521879611 0.878580824298291 0.0570875002261273 0.8886078557394 0.116806867460206 0.687321422272142 0.173894367686334 0.573400419363835 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATXN7L3B 0.110157432680302 0.707602869015251 0.903636202064089 -0.0002390263814026 0.999821029388173 0.999821029388173 -0.0273903189244164 0.947911024617876 0.487392743150042 0.0871660637156024 0.460002424225625 0.120165656424058 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYNC 0.139297513113462 0.707656609403199 0.903636202064089 0.0226339429231919 0.949282505558066 0.986917609553614 -0.188001870608424 0.899133462416421 -1.17812972055896 0.270368040403437 -1.36613159116738 0.258819904967629 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DLL1 -0.0978972943539514 0.707659027062758 0.903636202064089 -0.199818325514311 0.425940640673553 0.746651383734247 0.833587001163284 0.117936463347279 -0.619933372091107 0.135899113233107 0.213653629072177 0.703406292418632 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNTN5 0.177085327605728 0.707771954608128 0.903636202064089 0.319682386154073 0.493953511768614 0.786363265568912 0.541742932291498 1.0 True False False False False False False 0 insufficient_or_context_specific +EIF4B 0.0531726394054716 0.707826767760338 0.903636202064089 0.0584654054613413 0.679336741757853 0.880702028423307 0.270019801896647 1.0 -0.595331476817022 0.149029449922273 0.170666765801305 0.653084033206917 -0.424664711015718 0.263012090199481 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LSM14B 0.138155522815382 0.70786394307013 0.903636202064089 0.355959917921514 0.344368086536317 0.69073818751447 0.260276538159153 1.0 -0.153581896701281 0.5708428850004 0.208424188728022 0.334819040413064 0.0548422920267414 0.83294338016607 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZBTB4 0.0857019432083615 0.707958477531324 0.903636202064089 -0.108348469764358 0.62901510264491 0.858472266510466 0.233318623557863 0.277819747842789 2.0 -0.0320025808295463 0.928594534815115 -0.746450002339753 0.0096962369440699 -0.7784525831693 0.0114509654890827 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NR6A1 0.145675619527639 0.708068033687839 0.903636202064089 0.191015112278079 0.624729137515272 0.856338486330344 0.337991967980033 0.549689629041299 2.0 -0.732255812239605 0.18778214022247 -0.0668085949297953 0.906740648596025 -0.799064407169401 0.125447436005194 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZCCHC9 0.0731286009836529 0.708399467798012 0.903772295206127 -0.0031196779828564 0.987620133169211 0.996492103019929 0.0114137839314674 1.0 -0.216461004855697 0.573019196655599 0.192272460417125 0.525477202534026 -0.0241885444385719 0.949010089628798 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF100 -0.0980043461648849 0.708431475196619 0.903772295206127 -0.143868458416614 0.583921370883814 0.834132995585234 False False False False False False False 0 insufficient_or_context_specific +CENPJ 0.0777686265905888 0.708598418109121 0.903876053932113 -0.110736811907203 0.56805168489293 0.825129552905055 0.0238619405399203 0.969251940576763 -0.480428168676653 0.239468191495686 -0.456566228136732 0.318426315942166 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL26 -0.216051694989318 0.70940147879529 0.904572561971096 -0.513571723017143 0.352185817476713 0.696325442119688 0.4401288447210421 1.05385186057765 2.0 0.0147921491758844 0.973990024535509 -0.482054317515527 0.128732653862785 -0.467262168339642 0.168756375569454 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DGKE -0.149071890982159 0.709686905816859 0.904731779097946 -0.53614636361838 0.144388181284123 0.531908729238579 0.348123651806878 1.0 0.188185081785201 0.751864114640305 -0.0500321365220903 0.91714860580113 0.138152945263111 0.792871789850276 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MFSD10 -0.125437232329934 0.709731455158112 0.904731779097946 0.0805869936311656 0.814889943366629 0.935641141872961 0.431375747280434 0.203005481726065 -0.704043768511364 0.0270728474915667 -0.27266802123093 0.400219735588757 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LAMA5 -0.180951647355619 0.709985954847145 0.904731779097946 0.0450245631559538 0.925330713052081 0.978485542437683 -0.505498327728513 0.575400223101064 -0.824207362260749 0.272670665890858 -1.32970568998926 0.104106073041952 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PARD6G-AS1 -0.0909146555819654 0.710099734218961 0.904731779097946 -0.0432968628994925 0.859956704010367 0.956914759994669 0.366612591640669 1.0 False False False False False False False 0 insufficient_or_context_specific +SUPT16H 0.0861314470686495 0.710231466810425 0.904731779097946 -0.0306370646682868 0.895418201391541 0.967143260387918 0.139451812224201 0.50728522368695 2.0 False False False False False False False 0 insufficient_or_context_specific +GTPBP6 -0.136436372973597 0.710271563157793 0.904731779097946 -0.417188480540911 0.231335857632824 0.601518427890281 -0.28356359230246 0.258840084741288 -0.853099725756749 0.0039257809339864 -1.13666331805921 0.0021149694464937 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM219A 0.0795490089711776 0.710463600993707 0.904731779097946 0.0370339227165495 0.862884784177754 0.958148375052923 0.6113250858485101 1.0 -0.174133616014561 0.669602959462566 -0.333520554272479 0.292580474083506 -0.50765417028704 0.138303939022004 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF254 -0.0534066444485608 0.710524496797672 0.904731779097946 0.070523533128752 0.622722634357106 0.855079408706246 0.00523024688423013 1.0 False False False False False False False 0 insufficient_or_context_specific +LRMDA -0.10108474277313 0.710529001366136 0.904731779097946 -0.094394015103715 0.728838665179277 0.904012808833088 0.670869443522109 2.07950605776457 2.0 0.0070560098919941 0.992788933773383 -1.10023766977302 0.0345914410427534 -1.09318165988103 0.0451960799512713 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NR3C2 -0.073188940311373 0.710599491735109 0.904731779097946 -0.0608013457724408 0.75737968162054 0.914454644719928 0.61328953900417 1.0 -0.599055971077276 0.0657749925946476 0.917316262562228 0.0064918884583111 0.318260291484951 0.266746233628446 reversed False False False False False False False 0 insufficient_or_context_specific +N4BP2L1 0.114844657660955 0.710935314715136 0.9047892704605 0.0672165701657856 0.828905085239331 0.942947704141109 -1.07656852797151 0.0172431284881209 0.931498341900883 0.022478701782624 -0.145070186070623 0.722288427116584 reversed True False False False False False False 0 cross_species_direction_conflict +TBCCD1 0.107963385678541 0.7110374926175 0.9047892704605 0.476214689821672 0.0863415841787663 0.467677448123587 0.296556884551505 1.0 -0.182836722498741 0.63639150788863 0.193929974623664 0.516409498708186 0.0110932521249228 0.977946588754094 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IFT27 -0.130201737471172 0.711213299129271 0.9047892704605 0.0095211242629068 0.979210314896156 0.993800106187985 -0.0593617433475794 0.901577906130256 0.38074647786375 0.214496589529309 0.321384734516171 0.341347737578318 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BOD1L1 0.0493982980126726 0.711227764628805 0.9047892704605 -0.0417931613765569 0.751391337165336 0.912280328632891 False False False False False False False 0 insufficient_or_context_specific +LRCH1 -0.0877167132413516 0.711285370792021 0.9047892704605 0.0919135994929368 0.695312633877676 0.887929652374397 0.0639623905940421 0.852458702217809 -0.188304247400831 0.426186842736189 -0.124341856806789 0.646907208275291 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DYRK1B -0.136415946574727 0.711478174685976 0.904817234498133 -0.407483952624491 0.244544154718745 0.610669341516615 0.4937652296760189 1.0 0.199454349769277 0.497627947413535 -0.25785194333462 0.281175211232498 -0.058397593565343 0.841757393942021 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NSUN4 -0.0771779968598819 0.711494607063565 0.904817234498133 0.0494686681695309 0.813778888631169 0.93522123720125 0.0052557174369464 0.98828196103135 -0.32575629811818 0.161577743401439 -0.320500580681234 0.19743316146939 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HTT -0.0501738513663855 0.711564453309149 0.904817234498133 0.0273647281833724 0.83810969300111 0.9478289694297 0.230797086836158 0.396951752844392 -0.438369681524118 0.0659457432085125 -0.20757259468796 0.401896487236387 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BRCA1 -0.11143946134181 0.711819248130182 0.904952802033672 -0.181243768002353 0.54522426334954 0.815249649121151 0.396209321639181 1.0 1.97810454622521 0.0737706039612339 -2.17971448889082 0.0206701121772256 -0.201609942665604 0.898053462711266 reversed False False False False False False False 0 insufficient_or_context_specific +RAB14 -0.0703140448896343 0.711911793724699 0.904952802033672 0.133436434834149 0.486000186934219 0.782071323676502 0.240985094954209 1.0 -0.13443943977266 0.610965413555145 0.499609781598212 0.0305815284846226 0.365170341825551 0.105890125598245 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRPC4AP -0.0479960576959408 0.71192820360785 0.904952802033672 0.0670026545176645 0.5995912797075 0.843257280459236 -0.0568652316501273 0.844299139847568 0.330425638318779 0.106897487196593 0.273560406668651 0.200097280541583 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SULT1A1 0.104309131191371 0.712043385094021 0.904990256388909 0.0381112597708887 0.894016158571529 0.966191860460739 -0.588303283982437 0.102513978234068 1.11361231526828 0.0054451042448924 0.525309031285842 0.115056400959859 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC00467 -0.156917570171441 0.713197452304672 0.906073893993656 -0.188715851035246 0.656508393912497 0.871684912617742 False False False False False False False 0 insufficient_or_context_specific +ZDHHC3 -0.0674944512254941 0.713239262453237 0.906073893993656 0.0612089947391085 0.741580571183234 0.908728838272119 0.144114390576199 0.596454233907932 -0.179782677455114 0.403753487958263 -0.0356682868789149 0.895311082948626 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA0753 0.0687256075096824 0.713510996597941 0.906236432091577 0.235077237973418 0.21762760821052 0.589761880771731 0.6240841726420129 1.0 True False False False False False False 0 insufficient_or_context_specific +RTRAF 0.15693832217152 0.713538876679038 0.906236432091577 -0.140042756246469 0.740378923836432 0.908274440555399 0.35809273681628 1.0 -0.0270108496485375 0.93944039540832 0.0523601531507056 0.840000107142249 0.0253493035021681 0.931376207714533 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDC123 -0.0590533915095448 0.713890093108368 0.906573442751762 0.016625257068322 0.91845974031114 0.975930957742715 -0.0453486268448667 0.876566872609043 0.240664977512399 0.225441660257634 0.195316350667532 0.360134383299682 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR86 0.222710187071613 0.714297408953934 0.906881060788421 0.231036053031668 0.70472140901033 0.892309576013921 -0.131537896547054 0.807925685613921 -0.158058573927339 0.692887896743352 -0.289596470474393 0.49488130255551 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TOX3 -0.165991494518338 0.714497919469179 0.906881060788421 0.094893685345011 0.834748629533837 0.946341246710861 False False False False False False False 0 insufficient_or_context_specific +SUGCT 0.121588777244416 0.71451086587158 0.906881060788421 0.195769703727511 0.557327290318928 0.821101152222033 0.208670960257345 1.93502854529654 2.0 -1.4871688812446 0.0012406660861213 0.778995451872327 0.0261433812600676 -0.708173429372269 0.0397746564415796 reversed True False False False False False False 0 cross_species_direction_conflict +RFC1 0.0443618318310784 0.714541126886742 0.906881060788421 -0.0133340787424971 0.910748863470316 0.972165251291031 0.4321055982887009 1.0 0.36351243724278 0.156855134094165 -0.315354007941968 0.149669223789833 0.0481584293008122 0.86100050886697 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VEGFC 0.158967126833766 0.714942939787106 0.907057155685817 -0.136144374588632 0.753564114182366 0.913602082065829 1.01691979345668 0.005004315202238 -0.680945438282126 0.0246079859153381 0.335974355174552 0.248405364806512 reversed False False False False False False False 0 insufficient_or_context_specific +HMGN2 -0.110306985504036 0.714997667030235 0.907057155685817 -0.0107678263265133 0.972401807536453 0.992040338141303 0.5719305681707479 0.627962400650651 0.0293953869649285 3.0 False False False False False False False 0 insufficient_or_context_specific +PTS -0.0917899174345479 0.715044204089132 0.907057155685817 -0.143762445254409 0.564683314759394 0.823754286312897 0.335551916986924 1.0 -0.417102333651046 0.197474687095588 0.410555851216694 0.138185361957168 -0.0065464824343512 0.985741774065822 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SHOC2 0.0563124841385374 0.715352371295134 0.907182958944614 0.168193936909606 0.268097553551176 0.631965610715185 -0.119046514547301 0.685678336076267 0.401629354900365 0.0774466242472505 0.282582840353064 0.232991998640449 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MALT1 0.0848449655889133 0.715517745689455 0.907182958944614 0.135084691896466 0.562608853706873 0.823630654109424 -0.357447514507251 0.327594166098238 0.0460821599275848 0.897880268172767 -0.311365354579666 0.347617128195943 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RANBP2 -0.0677644847499553 0.71569745276395 0.907182958944614 -0.105111964621013 0.567483767022976 0.824849995454606 0.464208551780604 0.0574426845124493 2.0 0.0387008854515241 0.909561233524486 0.222506003218825 0.327709206888863 0.261206888670349 0.279893024623986 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARL13B 0.0519473155222755 0.715812323374176 0.907182958944614 0.0845477106292077 0.546645989567013 0.815603096463177 -0.426899932314927 0.183168081871039 -0.121362074580386 0.67930771491384 -0.548262006895313 0.0761991979471607 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TSEN2 -0.090426894817478 0.715840025182557 0.907182958944614 0.108370423689554 0.662407898735844 0.873717928995002 -0.173926650018706 0.692407629405813 -0.0273649046557819 0.942891623180218 -0.201291554674487 0.594461671378564 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BLVRA -0.0861219427893524 0.715842029020404 0.907182958944614 -0.010278908523475 0.964726728613745 0.990333962149141 0.201633571951226 0.604968023577395 0.163922437654589 0.585106636376459 0.365556009605815 0.262803420187281 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VIM -0.0965849761262251 0.716019338487136 0.907182958944614 -0.229278557667902 0.386679312553913 0.720477739899883 0.327896070063376 0.580906900835266 0.252418279988998 0.610724851932548 0.580314350052373 0.249077815077982 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TUT7 0.0753270498943685 0.716090783674613 0.907182958944614 -0.114729468856782 0.567979125471727 0.825129552905055 0.333040988470194 0.375581740844401 2.0 -0.140037345581358 0.610965413555145 0.118502715827224 0.602538512687415 -0.0215346297541343 0.936863880172112 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ELK3 -0.0652603447407579 0.716154839233111 0.907182958944614 0.0182020179310232 0.918857736396684 0.975930957742715 1.12761987819426 1.0 0.365716438939956 0.244345138176277 -0.305718277639656 0.253250728756377 0.0599981613002996 0.85698528212106 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATF6B 0.0646377603674112 0.716595024818793 0.907280282052622 -0.0133579998537878 0.940745736726682 0.984054846799435 0.0529090553504566 0.885896209712577 -0.0258134194712515 0.929613426272579 0.027095635879205 0.931376207714533 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF85 0.129421534766096 0.71695380214338 0.907516873639828 0.0446045494961417 0.89986771753835 0.968057977213875 True False False False False False False 0 insufficient_or_context_specific +GTF2IRD1 0.164066980879732 0.717462820923092 0.908052321182691 0.157118310490113 0.729082660143934 0.904012808833088 0.0560539889355295 1.0 -0.180454586950107 0.598018938557952 -0.376698781325155 0.17048795637518 -0.557153368275262 0.0692793109371916 partial_or_other True False False False False False False 0 cross_species_direction_conflict +BZW1 -0.106234648280031 0.717598214954641 0.908081522877158 -0.151771446047988 0.607016428965414 0.846951163871658 0.0145519509146507 0.969651685100975 0.200694726572912 0.439931451605123 0.215246677487562 0.435520380180173 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TNIP1 0.0706078295152874 0.7178292907402 0.908081522877158 -0.0092395368347995 0.96240347671166 0.989873931526713 0.485052029990329 1.0 -0.460965939226394 0.219932855846463 0.10043268746727 0.776997266845696 -0.360533251759124 0.296466335045517 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NKAIN2 0.174059375276195 0.717902400421664 0.908081522877158 0.425423237675637 0.396891518844347 0.727749332399898 0.0149086891003066 1.0 -0.0290849265390501 0.97379932226307 -0.617273478590481 0.30743625316513 -0.646358405129531 0.335698859720097 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PTPN23 -0.0961424693992834 0.717912723416242 0.908081522877158 0.187757347086935 0.482065841159275 0.780666906162311 0.315660716189602 1.0 0.208333190229317 0.52712239622571 -0.223984868861304 0.394511143612722 -0.0156516786319872 0.963592920213227 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBC1D17 0.0974950582609546 0.717915937815461 0.908081522877158 -0.0429867665203626 0.873134125473398 0.959263070839262 0.0533908920536494 1.0 -0.349548337648423 0.336314896478139 -0.0511840610008443 0.887337524258271 -0.400732398649267 0.224424509661635 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBBP5 0.0773859122274726 0.718419090048655 0.908609098315009 0.0836600131442007 0.696534572944339 0.888594975972248 0.548469132131684 1.0 -0.292725657224363 0.320349903765884 -0.383227788580212 0.136800909165625 -0.675953445804575 0.0261944399137104 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PDZD4 0.191325268636804 0.718938134869664 0.90900499744062 -0.123810064951275 0.810908028918954 0.933446028055639 0.688585116606007 0.217903955746435 -0.37207660169452 0.380236766509273 0.316508514911488 0.568431556700212 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC138150.1 -0.116652317222401 0.718990408564749 0.90900499744062 -0.401400539377139 0.203409057806184 0.576835372560841 False False False False False False False 0 insufficient_or_context_specific +RHBDF2 -0.135932930825752 0.719444643418088 0.909470371792166 -0.315747408821144 0.393446485765719 0.725337523435388 -0.14494361107736 0.699540904072445 -0.36762639963715 0.205240723211765 -0.51257001071451 0.10610738150025 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS23 -0.141126573333662 0.720104470097126 0.910195498058836 -0.18723108552913 0.635406735190965 0.861847932958146 0.649718210937182 0.5654872325886551 2.0 False False False False False False False 0 insufficient_or_context_specific +FAM228B 0.067954762741352 0.720291389468997 0.910322778311428 0.237568754094322 0.218366120617465 0.590550589518236 -0.206706166442234 0.76673004729392 -0.695308662646748 0.184945095017045 -0.902014829088982 0.128787731894526 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NINL -0.0624513781440291 0.720499087980245 0.910367325382411 -0.0270752011538424 0.876906215550816 0.960989240400635 -0.257844803803897 0.472481196016052 -0.80183289280214 0.0194370578684519 -1.05967769660604 0.0085974855976623 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ELMOD2 0.0873557186235046 0.720674254175973 0.910390845176441 0.142032734062362 0.562970917672461 0.823754286312897 0.406402075425718 1.0 -0.0373185706586596 0.932688595470735 -0.361624964152903 0.212132493360466 -0.398943534811563 0.208252007610153 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MARF1 0.0744768262886323 0.720758208249444 0.910390845176441 -0.267033980589243 0.183915860342611 0.565716727964854 -0.369482584625707 0.0962020820874513 -0.120890683895877 0.541763927308012 -0.490373268521584 0.0301314889515878 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMARCD3 -0.0925477034965334 0.720858416374105 0.910390845176441 0.0175069325470397 0.946151603655018 0.985432868134933 0.594106630247811 0.30888494966013 2.0 0.0275985481324347 0.956307099182698 -0.582115423854368 0.0933223197518544 -0.554516875721934 0.133467274422914 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IRF7 -0.186450944467935 0.720862612774678 0.910390845176441 -0.0690949027886192 0.896082417675244 0.967365865625278 0.61703552658889 0.039677624549012 -0.948171025036735 0.0043411408218517 -0.331135498447846 0.225343259290421 reversed False False False False False False False 0 insufficient_or_context_specific +DCAF13 -0.093525762650169 0.721280023442687 0.9107299510633 -0.177752266092879 0.499078968134854 0.789996363653342 0.027552214190238 0.936257534403958 0.0788039159165882 0.743310939135718 0.106356130106826 0.686019137769345 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CREM -0.0687165787811897 0.72132817175808 0.9107299510633 -0.0913236995961788 0.633409226517804 0.861544344844802 -0.561662644902623 0.0284039074692407 0.376728303772695 0.08727857019526 -0.184934341129928 0.413103700225897 reversed False False False False False False False 0 insufficient_or_context_specific +MTMR8 -0.126762900722709 0.72166130826562 0.9107299510633 -0.0105917874380068 0.975677657123464 0.992949014430083 False False False False False False False 0 insufficient_or_context_specific +ODF3B -0.144017000740272 0.721727980860601 0.9107299510633 -0.032941819978016 0.93678667175863 0.982574377153548 -1.96018778866686 0.0074275271450401 1.34052605779055 0.0312163810364773 -0.619661730876303 0.247369938682454 reversed False False False False False False False 0 insufficient_or_context_specific +DNAJC3 -0.0964982466970942 0.721732651352702 0.9107299510633 0.0373116062783869 0.89228247153405 0.965368150296491 -0.594957513087719 0.088711766350242 0.331719982762279 0.279411316174752 -0.263237530325439 0.413651579464874 reversed False False False False False False False 0 insufficient_or_context_specific +UBA6-AS1 -0.16373404153398 0.7217529335107 0.9107299510633 0.0267332064395283 0.953949670470048 0.987292667741163 False False False False False False False 0 insufficient_or_context_specific +PTMS -0.0814632942925503 0.721885718523861 0.9107299510633 -0.240651239279696 0.30022266826792 0.65844431482607 -0.305618623046266 0.537028830712017 -0.592194212596265 0.152619127191763 -0.897812835642531 0.0484956798450036 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANO3 0.186115408297566 0.721907459788668 0.9107299510633 -0.0430617117355053 0.933989811776035 0.981307618643649 False False False False False False False 0 insufficient_or_context_specific +GIN1 0.114099897676886 0.722018743110723 0.910761516100719 0.0179663055374672 0.955500487668779 0.987410276805219 -0.164013923337206 0.701769001297478 -0.0390443762978711 0.918111645717473 -0.203058299635077 0.579050544156534 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PHTF1 -0.0866305899271685 0.722208481677264 0.910892025988359 0.245675686026351 0.292802512391813 0.651509781962399 0.548964056741049 1.0 0.498731022743579 0.175719157968763 -0.621558126916535 0.0583316617888273 -0.122827104172956 0.747504020879527 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMIM2-AS1 -0.255380821904759 0.722446333627479 0.910977373712666 -0.281792671145337 0.694914104905639 0.887804754727944 False False False False False False False 0 insufficient_or_context_specific +PER1 -0.154929028452003 0.722509549794563 0.910977373712666 -0.457439477919073 0.276039300515969 0.6396696093258 0.965334522739147 0.478990696182409 0.100733232854709 3.0 -0.819315899052644 0.0400910875759061 0.426127735966543 0.213357689454571 -0.393188163086101 0.26921207916053 reversed False False False False False False False 0 insufficient_or_context_specific +SAMD4B 0.0504316423808098 0.722570204333905 0.910977373712666 -0.0883837853684959 0.537873142323972 0.812087893451657 -0.404450491164372 0.211588815674402 0.228512217238088 0.415899574998601 -0.175938273926283 0.568647573028081 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP005433.1 0.163454968450379 0.722621282898615 0.910977373712666 0.283565987197827 0.540215956079592 0.812783927483158 True False False False False False False 0 insufficient_or_context_specific +SNX24 -0.0656803982183029 0.722775410147554 0.911056751189065 0.122240347006073 0.506602629628378 0.793694993859091 -0.0592572441644905 0.916420446213497 -0.495906311388648 0.179389307609338 -0.555163555553138 0.18340894664916 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIR181A2HG -0.141909184156334 0.722889408256268 0.911056751189065 0.210053074247459 0.607352754500096 0.846972709287018 False False False False False False False 0 insufficient_or_context_specific +VCPKMT -0.0824947129292147 0.722943120047546 0.911056751189065 -0.13067171788999 0.572700358833269 0.827730374888659 0.697640079332522 0.25222582575647 -0.995146271841485 0.0565201777239656 -0.297506192508963 0.645748718997003 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDK4 -0.142581850198906 0.723402364244654 0.911303868877493 0.149016915734473 0.719774018371587 0.899654820203335 0.624358116445613 0.0326214333258712 -0.558731479566355 0.0313494588286616 0.0656266368792579 0.826338772451962 reversed False False False False False False False 0 insufficient_or_context_specific +ATAD1 0.0698802892459868 0.723404305764069 0.911303868877493 0.228830003057748 0.25187821208921 0.618547340340987 -0.0095221514975855 0.980936796694507 0.288148885571445 0.249564270176896 0.278626734073859 0.312567192566721 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LIN54 0.0902480439343623 0.723484469495278 0.911303868877493 -0.215473328653661 0.3904050828702 0.722218665388488 0.429331537601545 0.390158997399646 -0.192936405154167 0.630654097711886 0.236395132447378 0.621075470673116 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C2ORF92 -0.0839725173312284 0.723663053638022 0.911420078767772 0.0177021308410418 0.94198412110045 0.984366565940656 False False False False False False False 0 insufficient_or_context_specific +ZNF331 0.152738191081745 0.723888738605552 0.911443702500461 -0.440756370091261 0.260839717866127 0.623629017488807 0.221891409296967 0.5192453859013061 2.0 False False False False False False False 0 insufficient_or_context_specific +COG2 0.0782416236763218 0.72394079268506 0.911443702500461 0.365445654826909 0.0837672784680746 0.464779732481256 -0.141823441863285 0.743854376911001 -0.577800034470139 0.0880809187851517 -0.719623476333424 0.0537894975346923 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DPY19L1 -0.0741881457450329 0.72413316853876 0.911478534667553 0.1393627390532 0.518143052840211 0.800840369846825 -0.0484215147041379 0.918074166062344 0.2118094448019 0.499131474566398 0.163387930097762 0.644362352290082 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTCH1 -0.104951700287076 0.724267611072978 0.911478534667553 -0.0072103953260451 0.980937294982068 0.994237282696264 0.367306102249924 0.185874645503048 -0.165803068118331 0.499596925306736 0.201503034131593 0.435701950155282 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STIP1 -0.137777837483874 0.724370884204632 0.911478534667553 0.103586043732347 0.794349370297974 0.928063228447907 0.202651659234202 0.3995688662234779 2.0 0.0835924867545248 0.829010029691934 0.316029067260455 0.243373540862969 0.399621554014979 0.168391566121752 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1ORF198 -0.155676011701512 0.724500481936055 0.911496197364259 -0.0616453154169975 0.888610314385408 0.964276699808303 0.262821215857149 0.993619996228019 2.0 False False False False False False False 0 insufficient_or_context_specific +NFYA -0.112105852189868 0.724859745850156 0.91170890067853 -0.0437263941138086 0.890653127343669 0.964759999845538 0.239145887762581 1.0 -0.103352732493328 0.714980859653776 -0.406786562284125 0.0725966087119818 -0.510139294777453 0.0406828163957319 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STAT5B 0.0533672753146172 0.724863497527671 0.91170890067853 -0.0659490524590111 0.669352131142772 0.876101666520689 0.0843060129748243 1.0 -0.610496323032954 0.0530084782743035 0.464991130211726 0.0918745560398917 -0.145505192821228 0.624912250628054 reversed False False False False False False False 0 insufficient_or_context_specific +SPDYA -0.239678493375341 0.72525758915016 0.911848573130595 -0.657839324246049 0.329714920799116 0.678186271926176 0.57745069255449 0.55232432036509 2.0 False False False False False False False 0 insufficient_or_context_specific +WNK3 0.194932161855242 0.725670961962815 0.911848573130595 -0.228825141097209 0.678500025708425 0.880157669422479 0.3719969820232721 0.121940268605199 0.0916422330036015 3.0 False False False False False False False 0 insufficient_or_context_specific +R3HCC1L 0.0501196179679506 0.725767823231834 0.911848573130595 0.11055275771506 0.430656590807032 0.749361154407231 -0.218093433587145 0.54197599541736 0.0134131374890445 0.968056863216156 -0.2046802960981 0.516830859076533 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TBC1D4 0.0648575968777276 0.725875512831416 0.911848573130595 0.289056419402212 0.101437789748859 0.478335084675213 True False False False False False False 0 insufficient_or_context_specific +TTC33 0.0596637099816599 0.72592011235484 0.911848573130595 0.0122846446601304 0.942873668692371 0.984366565940656 -0.360920556930046 0.264678890021271 0.121852782501283 0.676510765054907 -0.239067774428763 0.420266581673045 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PTPRK 0.0895180342615789 0.725931418766862 0.911848573130595 0.113301422965199 0.656484580969244 0.871684912617742 0.262871320982605 1.0 -0.46724513761226 0.0907284595791442 0.444274819812271 0.0764193640046672 -0.0229703177999898 0.938502922811403 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRPL47 0.0967099624491693 0.72597296642792 0.911848573130595 0.294525853856275 0.301951099259158 0.65922243713362 True False False False False False False 0 insufficient_or_context_specific +KDM5C -0.0772388922912899 0.725995718591885 0.911848573130595 -0.0346110000364839 0.875421803936994 0.960395245514428 -0.195041678320532 0.402481427307569 -0.268983805323087 0.177228112638595 -0.464025483643619 0.0394592397807986 partial_or_other False False False False False False False 0 insufficient_or_context_specific +JRK -0.0998679048859588 0.72610829114803 0.911848573130595 -0.406871159322125 0.158792502166405 0.543060696740211 1.00043176701933 1.0 0.54517433604652 0.376045631782125 -0.0215203153458909 0.967256258171707 0.523654020700629 0.343765343360838 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GTF3C5 -0.0853519299712307 0.726208738469087 0.911848573130595 -0.186801809093423 0.437520298390965 0.754535640189682 1.22395665963516 1.0 -0.0024785367192913 0.996458519322138 -0.163283735297671 0.614577795847454 -0.165762272016962 0.651287933622503 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM117 0.0624285386252159 0.726320916953969 0.911848573130595 0.186919154653367 0.279634656342215 0.642114507827558 True False False False False False False 0 insufficient_or_context_specific +SKAP1 -0.151586252806589 0.726335148705087 0.911848573130595 -0.26673746330276 0.53166650087206 0.808721353725286 False False False False False False False 0 insufficient_or_context_specific +AKNA -0.0811103033585872 0.726657290403613 0.911927691915054 -0.271857405119709 0.228483905469822 0.60038155150582 0.345117115283165 1.0 0.434284395738437 0.26778031421187 -0.316569601294949 0.322285455025229 0.117714794443488 0.769914276490153 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AMOTL1 -0.061041529264192 0.726972875987974 0.912184220781648 0.0999938669525498 0.563664661287842 0.823754286312897 0.4898441242531911 1.0 0.652448498424923 0.0382600499827002 -0.456010950326242 0.0914003282017052 0.196437548098681 0.498630574182122 reversed False False False False False False False 0 insufficient_or_context_specific +SMARCA2 -0.0687144616155399 0.727240973487933 0.912334861939829 0.0664051275585667 0.727948996203418 0.903772989406831 -0.294599614332055 0.319299600821284 0.582551748833972 0.0340010371508872 0.287952134501918 0.279067388409847 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GSTA1 -0.259295725162626 0.72811702239869 0.913012579850311 -0.0301759490482794 0.969607805440505 0.991737938845345 False False False False False False False 0 insufficient_or_context_specific +CCL21 0.212167479385835 0.728155061928094 0.913012579850311 0.578195618865575 0.348117988256788 0.693734774979578 0.590555257185239 1.0 True False False False False False False 0 insufficient_or_context_specific +AC106729.1 0.196827548157926 0.72817807801304 0.913012579850311 -0.0158492414035562 0.981482439069841 0.99451887511202 False False False False False False False 0 insufficient_or_context_specific +EMP2 -0.0977768125577832 0.728317727704292 0.913012579850311 -0.223778499654129 0.425355787217217 0.746056682180874 0.346784498104004 1.0 0.429140139675961 0.343742121069858 0.106036936371931 0.787756677304417 0.535177076047892 0.192133427834068 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STON2 -0.167312800963523 0.728351516858523 0.913012579850311 -0.334365282255689 0.483867379351977 0.780666906162311 -0.165669725150716 0.832062370167634 0.0601716134546587 0.919228163577521 -0.105498111696057 0.876230639759628 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RUVBL1 0.0818258100047339 0.728594531799842 0.913012579850311 0.230593288801454 0.339656410786544 0.687254194151846 0.258840463412773 1.0 -0.375531219212613 0.26778031421187 -0.388225914554428 0.192211059565639 -0.76375713376704 0.0284376587046979 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TECR -0.114207897900464 0.728745751741825 0.913012579850311 -0.0057046392453734 0.987240344851935 0.996204105987454 -0.226277850502383 0.427842744261142 0.64316940449771 0.0182984738337256 0.416891553995327 0.104275300791958 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTGIR -0.112730213187967 0.728876226704016 0.913012579850311 0.274803406995499 0.412240573579868 0.735291083225579 0.556119751934533 1.0 1.87978352776441 0.0183932811700373 -0.676040945409759 0.188278444546047 1.20374258235465 0.106313701827322 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF267 0.121036704821254 0.728960653633235 0.913012579850311 0.489691335632777 0.164895487406627 0.545094551255265 0.0168863920583499 1.0 True False False False False False False 0 insufficient_or_context_specific +TRIM2 -0.0877452171180312 0.728984743040291 0.913012579850311 -0.0404542791344584 0.87334825129958 0.959263070839262 0.0291033852202077 0.947911024617876 0.323042232181686 0.260003460991761 0.352145617401894 0.253965091977913 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAH14 0.160555651759248 0.729129844090497 0.913012579850311 0.0120993468716962 0.978823980097367 0.993800106187985 True False False False False False False 0 insufficient_or_context_specific +GNA14 -0.171181017654188 0.7292212053547 0.913012579850311 -0.0134451016636233 0.978162165727581 0.993500350721674 -0.369127916880557 0.509438836817559 0.560998908171591 0.190321681464416 0.191870991291034 0.704019087595202 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS5 0.0593586669757927 0.729370454972365 0.913016722438216 -0.0641162761138898 0.701664212208497 0.89138518967732 False False False False False False False 0 insufficient_or_context_specific +RAD1 0.164685126219458 0.729427548187759 0.913016722438216 -0.199713338530509 0.677050832447494 0.879574589514044 0.35758424785661 1.0 0.256885201679924 0.690038981640459 -0.422179857753276 0.367897920048687 -0.165294656073351 0.785800517185713 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABHD15-AS1 0.116780866232636 0.730138624956657 0.91341181798433 0.47886340061957 0.157623587520009 0.541024004238054 True False False False False False False 0 insufficient_or_context_specific +SYNGAP1 0.0765663108207924 0.730175766602363 0.91341181798433 -0.0746397263510494 0.735985464472773 0.905764683303975 0.236227857469575 0.730417369909899 -0.756517853259062 0.154087822776525 -0.520289995789488 0.353671246088597 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCNH7 -0.27069707436336 0.730689189662308 0.913744462129578 -0.693851976998921 0.339886366072658 0.687324315838944 False False False False False False False 0 insufficient_or_context_specific +LBP -0.170920981695369 0.730730074753845 0.913744462129578 -0.382949519859481 0.446634814682722 0.761436063265649 -1.74186233268152 0.0003042757338565 0.931373696268793 0.0091920347644963 -0.810488636412729 0.0206212459289334 reversed False False False False False False False 0 insufficient_or_context_specific +AL050403.2 -0.0939157319373608 0.730855833317127 0.913744462129578 0.0905355582823392 0.742605959368519 0.909193347184915 False False False False False False False 0 insufficient_or_context_specific +GTF2IRD2B 0.074042664069304 0.730874406391768 0.913744462129578 -0.255998209657115 0.21436706032011 0.587561636256419 False False False False False False False 0 insufficient_or_context_specific +AC007388.1 0.0889969341253684 0.731256299058436 0.914005446366635 -0.0790327875537265 0.762376670737815 0.916603852905611 False False False False False False False 0 insufficient_or_context_specific +SMS 0.0876884054442914 0.731505076594788 0.914014458927124 0.113336880008433 0.65627118416839 0.871684912617742 -0.356117987480939 0.457148437429949 0.0879680690212424 0.835678587445242 -0.268149918459697 0.535804547819139 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NCBP2 -0.100035165659203 0.73165527479814 0.914014458927124 -0.197514006803957 0.494593210941117 0.787126014461539 0.456304880584355 1.0 0.165660517796886 0.593788663106486 0.092776115810852 0.718142679060976 0.258436633607738 0.323069715819368 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UGT2B10 -0.260533396056014 0.731664217291082 0.914014458927124 -0.0263930983429006 0.973356171142275 0.992355823557447 False False False False False False False 0 insufficient_or_context_specific +DUSP16 -0.0983963250183232 0.731850656075863 0.914014458927124 -0.153318287810161 0.593944734459778 0.839773552750704 -0.173957063644317 0.682427626091247 -0.276159330398644 0.396136268726948 -0.450116394042962 0.201587177268485 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF431 0.0717610186915051 0.731873320417469 0.914014458927124 -0.0128892441986293 0.95080521529181 0.986917609553614 False False False False False False False 0 insufficient_or_context_specific +BNIP2 0.065889232941433 0.732049187803193 0.914014458927124 -0.101814395084172 0.600215804380674 0.843257280459236 0.0300049033660868 0.92307968807918 -0.497409508271411 0.0308307222802141 -0.467404604905324 0.0486820039952168 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EOGT -0.11284485409998 0.732071137577902 0.914014458927124 -0.0009004350797254 0.998572946542393 0.999257679999277 -0.0190836308444509 0.97182531653633 -0.0695112698192701 0.864849966799431 -0.088594900663721 0.844664668666479 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRIM26 -0.0697057163845284 0.732129217574038 0.914014458927124 -0.0724564771758134 0.721769333156768 0.901057712595039 0.0197224454438552 1.0 -0.191462188302405 0.538636281279204 -0.545053871422692 0.0463700371730369 -0.736516059725097 0.0192554552464092 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HS1BP3 -0.0959193145308061 0.732375445752372 0.914114320518068 -0.0752164599614847 0.789061059266709 0.926945619655161 0.250067604160694 1.0 0.219711433266972 0.48947242872329 -0.248654024818647 0.336238944439673 -0.0289425915516752 0.92923636652208 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BRINP1 0.191821721192369 0.732382367613405 0.914114320518068 -0.0965549613893313 0.858879728966629 0.956914759994669 0.765857329911804 0.703137339315104 2.0 False False False False False False False 0 insufficient_or_context_specific +CBX5 -0.0655314535842188 0.732688266574811 0.914245982671855 0.145352775765523 0.458389185255016 0.768146176023338 0.202211522802081 1.0 0.221455878945007 0.402553048791229 -0.0450819460338062 0.855080820727044 0.1763739329112 0.460383476953904 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HACD3 -0.0771774749339254 0.732704238698362 0.914245982671855 0.101697199908321 0.64082305909102 0.864640237429136 -0.130606803551408 0.761766960195343 0.530513484175775 0.103871836610197 0.399906680624367 0.235061424921574 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUFIP1 0.115972946572293 0.732888107403168 0.914245982671855 0.0307036815108309 0.927410385551 0.979087152943213 0.7613666461991669 0.943488550195643 2.0 -0.419745991319219 0.275986820266038 -0.227628580135862 0.499411753052289 -0.64737457145508 0.0800449285046981 partial_or_other True False False False False False False 0 cross_species_direction_conflict +UNC93B1 -0.16705530020192 0.732955298230965 0.914245982671855 -0.507662348722258 0.265071414262246 0.628057448783841 0.364585692279604 0.139403813032401 -0.547579167750432 0.0219221055639799 -0.182993475470828 0.429469654635187 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ECI2 0.0616575790201037 0.733009376781588 0.914245982671855 -0.0461498450327079 0.793191579630763 0.927620871373898 0.0171921369419608 1.0 -0.404237922944897 0.361820986612172 0.563314677681282 0.142070362261614 0.159076754736385 0.71085094565801 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TAF11 0.073454272080508 0.733094003532859 0.914245982671855 -0.0843377732927154 0.693501815318266 0.887084100573086 0.744696398088177 1.0 -0.141155617294734 0.681898840040898 -0.232026603189962 0.381944116760868 -0.373182220484697 0.18976418484692 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDK8 -0.0702325717744588 0.733638497341491 0.914603433769168 0.108896216510458 0.596169481817747 0.841062705567846 -0.0462625483076445 0.868885408601504 0.191168922398203 0.322285455025229 0.144906374090559 0.487856877889904 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TUBD1 0.0824990914818072 0.733640507727892 0.914603433769168 -0.19881200788992 0.415383764115653 0.737327132066756 0.983100211286044 0.0177327627108038 -0.840730510387463 0.0166606814192818 0.14236970089858 0.732487073064233 reversed False False False False False False False 0 insufficient_or_context_specific +MZF1-AS1 -0.0988567933308477 0.734029418520429 0.914790491218717 -0.0315375924369131 0.913809734585105 0.973857189638593 0.595429313426846 1.0 False False False False False False False 0 insufficient_or_context_specific +ZNF182 -0.11862191885714 0.734093379721703 0.914790491218717 -0.597827020020958 0.0621221005591559 0.431813959784778 False False False False False False False 0 insufficient_or_context_specific +NEXMIF 0.157120302809255 0.73444693792508 0.914790491218717 0.0609018904592064 0.893641643760276 0.966113913047409 True False False False False False False 0 insufficient_or_context_specific +RNF138 0.06976579647634 0.734472968622036 0.914790491218717 -0.0527969252763822 0.798152921546321 0.92925379048471 0.219506419980769 0.489643885732232 -0.241727280367972 0.34342356809709 -0.0222208603872035 0.945443098692126 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDZK1 -0.146496759291421 0.734496277744159 0.914790491218717 -0.24402863418703 0.570282546956929 0.826196804464902 -1.17593443619726 0.0097274209644883 1.30219558326849 0.0046641092992809 0.126261147071236 0.751669464110695 reversed False False False False False False False 0 insufficient_or_context_specific +LRRCC1 -0.138942886848784 0.734528719413699 0.914790491218717 0.23039572550932 0.583346458970919 0.834132995585234 -0.436834532888529 0.213243567460253 -0.827036500109148 0.0207212764312278 -1.26387103299768 0.0052416072042819 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANXA11 -0.0657115128274074 0.734570352770627 0.914790491218717 0.0944626806670792 0.630844966857259 0.859692738990112 -0.132375642655303 0.692468360812531 0.483859108752833 0.0653276421182545 0.35148346609753 0.194546743898624 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF362 0.0899732306791068 0.734996489415679 0.914897217910565 0.140389034939568 0.597168266962467 0.842000876414226 0.42549783832682 1.0 True False False False False False False 0 insufficient_or_context_specific +GOLGA1 -0.073986390777889 0.735045446362448 0.914897217910565 0.0016084983361015 0.99410636234743 0.99854504652634 0.382399647520588 1.0 -0.491640944992595 0.0692404679085664 -0.493168933042059 0.0515536560618326 -0.984809878034654 0.0041412353303569 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLA2 -0.105272276331389 0.735135076091165 0.914897217910565 -0.488410640405625 0.0994624925166982 0.478125555523304 0.883760000455244 1.0 -0.0768639786028808 0.869015643979454 -0.669243188271579 0.0522908096408987 -0.746107166874459 0.0490556441432384 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IMPACT -0.0945367798560996 0.735242577253871 0.914897217910565 -0.019730439812356 0.944752296431667 0.985105732892783 -0.512318078557157 0.11347364555644 -0.197032939226539 0.493676718587069 -0.709351017783696 0.0313324864278656 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DHDDS 0.0764684530272531 0.735310348843054 0.914897217910565 -0.0163509396556199 0.941242340584967 0.984111856389759 0.669182411050228 1.0 -0.152419157176987 0.594093355400225 0.172567234772879 0.446166812302206 0.0201480775958923 0.942660682843177 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01285 -0.172870227902636 0.735402116147888 0.914897217910565 -0.211019786205153 0.680314756780068 0.881048329971919 False False False False False False False 0 insufficient_or_context_specific +MRPS6 -0.14574768232548 0.73549939579979 0.914897217910565 -0.0126441903203848 0.976606172775978 0.992970766113577 False False False False False False False 0 insufficient_or_context_specific +CPNE8 -0.0659618107029552 0.735725068971246 0.915041262598471 0.159688139972147 0.410491741986244 0.735152897523944 -0.325621774285914 0.205545898991761 -0.468737171870663 0.0517261044839709 -0.794358946156578 0.0084245433417565 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PITRM1 0.0658918283892311 0.736056843398577 0.915346072155734 -0.172977776077036 0.420781905979454 0.742471251256147 0.25783027081148 1.0 0.294047245577595 0.255762171995354 0.094054148761809 0.677585067137296 0.388101394339404 0.107065915490912 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAP1GDS1 0.0638358267146726 0.736249516776803 0.915394024503799 0.251601861896728 0.18105025377549 0.563603217043398 -0.0194987112537587 0.965039629475732 -0.178241766332514 0.556861518445539 -0.197740477586273 0.553397724125437 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COPB1 -0.0474251859630957 0.736268806221468 0.915394024503799 0.0917157293388405 0.522437154249279 0.802661739604756 -0.174358214210047 0.47133043795982 0.378259382007931 0.0672879620550469 0.203901167797883 0.332496888140221 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF236 -0.0668490046162712 0.736514965399881 0.915506591672755 -0.11500754801915 0.555829495118235 0.820532411837013 False False False False False False False 0 insufficient_or_context_specific +ACSF3 -0.0807372140247473 0.736532770379654 0.915506591672755 -0.145941381166857 0.538108249961635 0.812087893451657 -0.0856956845541877 0.849781671671633 0.479397057750118 0.111353765785177 0.393701373195931 0.226942829865253 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC114763.1 -0.0992443916728161 0.73672980769121 0.915643709194091 0.191064588062466 0.513650923913715 0.798491683514042 False False False False False False False 0 insufficient_or_context_specific +NAPG -0.0722511576647318 0.736858987758723 0.915696468073988 -0.0270880405462614 0.900514398716384 0.968057977213875 -0.0755544664866454 0.800153450912311 -0.393838477726184 0.0785031474596826 -0.469392944212829 0.0552867420013502 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NARF 0.0934023891399882 0.737047284459491 0.915714901073583 -0.163593058935847 0.550278998960861 0.817186218568941 0.566992356174059 1.0 -0.237255328826326 0.519104668914167 -0.033486638744775 0.924022101894769 -0.270741967571101 0.396809900615665 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF2S3 -0.0589579706845565 0.737255794302981 0.915758432500103 0.0753121371975437 0.65367881979121 0.870639750062571 False False False False False False False 0 insufficient_or_context_specific +AC104461.1 -0.13683196104915 0.737370507789267 0.915793179771683 -0.0146679287074136 0.972268548190356 0.992040338141303 False False False False False False False 0 insufficient_or_context_specific +C11ORF65 -0.0871665099695006 0.737480290219902 0.915821795358942 0.218943852335813 0.38215659637129 0.718152491804259 False False False False False False False 0 insufficient_or_context_specific +MMRN2 -0.155809239499095 0.737806658882345 0.916011606829704 0.0488826876875295 0.917091502955522 0.975930957742715 False False False False False False False 0 insufficient_or_context_specific +AC087463.4 0.14693606989713 0.738130620870467 0.916230877617737 0.209358442079911 0.635340710303677 0.861847932958146 True False False False False False False 0 insufficient_or_context_specific +ATP5PB 0.118963092294886 0.738283023464341 0.916279788613673 0.629246645151984 0.088035034690848 0.468622105620855 True False False False False False False 0 insufficient_or_context_specific +HS3ST3B1 -0.138325042502592 0.738669650613389 0.916387651385983 -0.305326046382949 0.447070957561683 0.761469121135878 0.216571677477285 0.366245320900213 2.0 -0.100171122702364 0.794646203070559 -0.211922926111545 0.45967352600293 -0.312094048813909 0.294212716086033 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HPD -0.179927630627829 0.73867464564526 0.916387651385983 -0.228939439660288 0.671058024283004 0.876751716418755 0.602500567565782 1.05860063470136 2.0 -1.57622509344266 0.0030440971219126 2.02678778973511 0.0011023600906998 0.450562696292453 0.258583636659547 reversed False False False False False False False 0 insufficient_or_context_specific +ZSWIM9 -0.080970006800083 0.738833322154117 0.916424132436933 -0.166826394566391 0.492732055266658 0.786325382313799 0.21538288432429 0.764177252940569 -1.1839711310436 0.0425463636841992 -0.968588246719305 0.124789995071056 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UGP2 0.0838171610317162 0.739044206481358 0.916578025611438 0.349073306958243 0.143512721148607 0.529978072713184 0.227078068408312 0.513538955836065 2.0 -0.426042545195705 0.310218662957511 1.01971651380002 0.0139573704372748 0.593673968604317 0.118941592988843 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC087280.2 -0.130116996480509 0.739219299044987 0.916661712009929 0.193244519953227 0.629927330092959 0.85897526668397 False False False False False False False 0 insufficient_or_context_specific +HERC6 -0.160241517222142 0.739318439220104 0.916661712009929 0.0816779752147069 0.867793421404138 0.958502690861149 0.884043654487751 1.0 -0.323288246876061 0.573619496442142 -0.899038101937054 0.069261697533917 -1.22232634881311 0.0284376587046979 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATXN7L1 -0.0443222123127345 0.739398726350589 0.916661712009929 -0.040184806352785 0.762079301494845 0.916563228182353 0.539838822292924 0.316879761397866 2.0 -0.0776986697439644 0.824729227637569 -0.396648460002609 0.120135669877274 -0.474347129746574 0.0835098265893373 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FNBP4 -0.0445916316190685 0.739594467298963 0.916661712009929 0.0023914939760609 0.985859289979491 0.995662563940518 0.081697826207197 0.819083985159194 -0.121329642676002 0.646005891410354 -0.0396318164688054 0.900726193373946 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZDHHC18 0.103796593629803 0.739852785624571 0.916661712009929 0.343083351376027 0.273731107907971 0.637441209463408 0.947275857199151 1.0 -0.418287454566764 0.109165896250983 0.165453904112124 0.469835350874794 -0.25283355045464 0.290854741837056 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LRP5L -0.123520047393763 0.739857581209529 0.916661712009929 -0.180769240543727 0.624827977848811 0.856338486330344 False False False False False False False 0 insufficient_or_context_specific +NTMT1 -0.0848057841148029 0.739995198512757 0.916661712009929 -0.284216916988706 0.256133769406436 0.620670263344767 0.6239627388381329 0.906642308266163 2.0 0.306879559401512 0.366678751917136 -0.317201040090498 0.250910392550885 -0.010321480688986 0.979042156415147 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PITHD1 0.0912506721179749 0.740008457532661 0.916661712009929 -0.0850319661133785 0.752475063596654 0.912996564506704 0.536901122520994 1.0 -0.0472069299201405 0.950029058814111 0.454713795094094 0.339944367778569 0.407506865173953 0.44116511405308 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AFF4 -0.0638664914516293 0.740091261626967 0.916661712009929 -0.210507787838719 0.270537332513451 0.634531964851516 0.166410057095563 0.596684192675644 -0.0136140772912939 0.962937369670483 0.152795979804269 0.581271452691796 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABCA1 0.0525211313238063 0.74027126927967 0.916661712009929 0.0810090718464221 0.606079624149465 0.84687515507809 0.552343519330825 0.287606446288018 0.127744222836003 3.0 -0.227305038673592 0.424983650709669 -0.165689917916354 0.496735249709655 -0.392994956589946 0.124999600749061 partial_or_other True False False False False False False 0 cross_species_direction_conflict +USP2-AS1 0.182874910041951 0.740293116053415 0.916661712009929 0.574673414866156 0.334568362320214 0.684303132386056 0.0205135868156688 1.0 True False False False False False False 0 insufficient_or_context_specific +CYP20A1 -0.0545674867413189 0.740322886563514 0.916661712009929 -0.0572927045854636 0.727245447408306 0.903365569206837 0.0337278520931625 0.339690654139399 2.0 -0.140530296451459 0.661840388701911 0.56177455142809 0.0376749301958875 0.421244254976631 0.115254966818342 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APOC1 -0.0953464064955505 0.740552892077855 0.916833657898451 0.366552151606231 0.205586219621374 0.578666837313374 -0.971864097236241 0.13530535760217 1.90308605492714 0.0080807149151296 0.931221957690903 0.12452471071038 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NEO1 0.0807466163670638 0.740914177335706 0.917173394807173 -0.0208060716986332 0.932622263354244 0.981045440677165 0.446811085107214 0.392166681650196 2.0 0.16092660963459 0.692071541852603 -0.108648223326843 0.735860085682693 0.0522783863077466 0.894133440094522 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUMA1 -0.0536003860619626 0.741380654985781 0.917423589308575 -0.16949099254013 0.279834961176486 0.642114507827558 -0.177519663184258 0.537012158146185 0.0464346625200867 0.861628794546181 -0.131085000664171 0.61332970301658 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NBEAL2 -0.134962628769787 0.741481841512431 0.917423589308575 -0.116396841037807 0.777296894936052 0.922929913000972 -0.154006475175494 0.68614406247997 -0.450937957374499 0.12850673715884 -0.604944432549993 0.0704794987806679 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAJC24 -0.0617704925413983 0.741637652467199 0.917423589308575 0.179769347228945 0.352900194012838 0.696954778972604 -0.522666242863935 0.0677011241793959 0.292387031240546 0.232426402261097 -0.230279211623388 0.37576124382096 reversed False False False False False False False 0 insufficient_or_context_specific +MLLT6 -0.0574091932201735 0.741872435058716 0.917546802301419 -0.0446764535412917 0.797958655588131 0.92925379048471 0.5922916604790849 1.0 -0.423075978250611 0.120905679916346 -0.282440578664811 0.239615881413648 -0.705516556915422 0.0170274726711647 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VCL 0.123521063590758 0.74202961169941 0.917546802301419 -0.0801428033612281 0.836886453974755 0.947349959049485 0.635938503206572 1.0 0.572503799706002 0.0821149413086562 -0.192860290311886 0.508282488607835 0.379643509394116 0.20994211373405 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GDPD5 -0.094726841036423 0.742084878277308 0.917546802301419 -0.252105789571476 0.371827077383108 0.710285920573703 1.29777214612337 1.0 -1.23759159691345 0.0193491955432514 0.547989234536233 0.208084507232816 -0.689602362377221 0.120523252017019 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOCT 0.129832916281942 0.742306121151737 0.917593417567984 0.383668805480285 0.323224346003685 0.673495686818019 0.4119488465476579 1.0 -0.509778181172991 0.603562155863719 1.1502127389635 0.123980604873741 0.640434557790513 0.418053378097989 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF26 -0.0569314222389413 0.742636614026587 0.917593417567984 -0.0710682098732883 0.681554610118311 0.881539414637616 False False False False False False False 0 insufficient_or_context_specific +SLC23A2 -0.0657219607122772 0.742777403548452 0.917593417567984 -0.0500295095838947 0.801942758764658 0.930781165449847 0.5800675258666801 1.0 0.133610719329714 0.715391411274372 -0.336350881332102 0.22615595912348 -0.202740162002388 0.510081097589319 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AHRR -0.103328531013278 0.74278912992686 0.917593417567984 -0.402796076022685 0.195460303830472 0.571500015361699 False False False False False False False 0 insufficient_or_context_specific +SOD1 -0.0791851090867405 0.742881239789707 0.917593417567984 -0.0547503396521139 0.820573882989948 0.937925631331371 0.0176710723501267 1.0 -0.949726050438831 0.0918761191864373 1.45956054051411 0.0125509751703629 0.509834490075282 0.318961731398411 reversed False False False False False False False 0 insufficient_or_context_specific +USP40 0.0479450469847039 0.74306477886489 0.917593417567984 -0.122869373599791 0.41570892151781 0.737532312785253 -0.103309523992475 0.713431673907784 -0.586604206379783 0.0182769117749003 -0.689913730372257 0.0131086841178374 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF608 -0.119866397987628 0.743119212433677 0.917593417567984 -0.114418417018435 0.754484074896821 0.913618862571469 0.94016394390708 1.0 False False False False False False False 0 insufficient_or_context_specific +RASGRP3 0.115419116877047 0.743175986459415 0.917593417567984 -0.0102459824034273 0.977735866967685 0.993500350721674 0.346687601148988 0.511530355664917 -0.403753745544407 0.314247066047694 -0.057066144395419 0.918258746367039 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPRD -0.122126756731717 0.743252406425592 0.917593417567984 -0.285074466676239 0.445615811208856 0.760927015161427 -0.810681235040035 0.0663323696670329 0.818417047070966 0.0429621316207372 0.0077358120309312 0.987327189296956 reversed False False False False False False False 0 insufficient_or_context_specific +NOP53 -0.115363506650983 0.74346842836842 0.917752796295309 -0.380034359335189 0.268762728535051 0.632971449177233 0.6947234710095589 0.38444900956639 2.0 -0.379418933637506 0.192174733359028 -0.416830950098383 0.111897062577562 -0.796249883735889 0.013759890655975 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SERPINB6 -0.0635970984482357 0.744087293811128 0.918123542698241 0.0867167053448599 0.649413447987963 0.869246612356457 False False False False False False False 0 insufficient_or_context_specific +SCAMP4 -0.0862326521890483 0.744231142961151 0.918123542698241 -0.226492599787206 0.397386524538646 0.728024800638387 0.683658493634364 0.515535203066154 2.0 False False False False False False False 0 insufficient_or_context_specific +DNAJB2 -0.0873242272189382 0.744272473735197 0.918123542698241 -0.0846357364206226 0.751971832407491 0.912880143331986 0.124050788679592 1.0 -0.543728692307657 0.10108894556091 0.0838929660098508 0.7884615540991 -0.459835726297806 0.135275628399412 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DENND5B 0.0537663963377957 0.74435025078842 0.918123542698241 0.16495601181293 0.312708228212871 0.665103439458398 -0.176339165123299 0.587465260569338 0.0718844612362933 0.798280748489443 -0.104454703887005 0.727281137768212 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RSL1D1 -0.107397591537724 0.744423891024771 0.918123542698241 -0.183928285165514 0.572240201991584 0.827730374888659 False False False False False False False 0 insufficient_or_context_specific +SF3B2 -0.0791866474651649 0.744464448668275 0.918123542698241 -0.36607761687596 0.122595520578898 0.5038394341269 -0.261138697957542 0.330669677459799 0.381205954340545 0.1061537646033 0.120067256383004 0.641046230290678 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC1A1 -0.151633276645765 0.74472929713821 0.918168232062594 -0.196449901833828 0.672817499788613 0.877361032137705 False False False False False False False 0 insufficient_or_context_specific +CASP8AP2 -0.0612908172557903 0.744839422003107 0.918168232062594 -0.152481567353779 0.406712570877202 0.733961461951707 0.186851981611109 0.703159281983927 -0.418482331541645 0.245824670346556 -0.231630349930536 0.591591754617842 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POM121 0.0465421474657643 0.744848542111775 0.918168232062594 -0.0395164866882178 0.781025844396595 0.924191508936905 -0.179370356212548 0.517999474047107 -0.237936296926095 0.290769554599853 -0.417306653138642 0.0925896143249023 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FRMPD4 0.258859475535361 0.745263464946668 0.91838944593552 -2.08236500986007 0.0023978494077457 0.224500148429329 False False False False False False False 0 insufficient_or_context_specific +TRUB2 -0.0791374865461843 0.745311467133191 0.91838944593552 -0.0016444076238547 0.995255461502992 0.998795540446485 0.981112277016335 1.0 0.113341681569502 0.784039873542692 -0.407285398087481 0.174543794538748 -0.293943716517979 0.373879874807838 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAN1A2 -0.0603083445864249 0.745488798384652 0.91838944593552 0.158874707056554 0.381604378245339 0.717794232231301 0.3695304530072 0.14972440690911 -0.0379634162011667 0.879429870765751 0.331567036806034 0.163565371504678 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NT5DC1 0.082068086594971 0.74560209771243 0.91838944593552 0.0746952934480603 0.767927174644644 0.919665960741623 -0.340096276724111 0.283680773601636 0.0728756545257481 0.805823742723023 -0.267220622198363 0.356255613983658 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAOA -0.173973832245354 0.745619893181221 0.91838944593552 -0.387302521367849 0.46744171587323 0.7723395361799 0.0428572391619087 1.0 0.904339128408431 0.0592040773131088 -0.223972046604626 0.529911393705376 0.680367081803805 0.128446370068923 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TEAD1 -0.065035638808837 0.745636894351135 0.91838944593552 -0.252300221604733 0.214740063186178 0.587852789707652 0.2791211738360529 1.0 0.532173943773586 0.0509801141691565 -0.642462721340559 0.0163154553971817 -0.110288777566973 0.678053257147297 reversed False False False False False False False 0 insufficient_or_context_specific +STAT4 -0.0951564892528553 0.74602026941771 0.918754462208349 0.0740084689381944 0.800679351469657 0.930088303753618 False False False False False False False 0 insufficient_or_context_specific +HGD -0.23717898402109 0.746622852252955 0.919189349632913 -0.381108268317303 0.603551297934474 0.84524401161854 -1.26767216728695 0.0181972958372452 1.55341212504198 0.0057344291286823 0.285739957755023 0.544694713956342 reversed False False False False False False False 0 insufficient_or_context_specific +PPP1R15A 0.137480542537708 0.746911030495654 0.919189349632913 -0.0819420690798043 0.848116917203592 0.953104673958013 0.356594016405229 1.0 -0.355637233848401 0.275792151192826 0.333420195499592 0.226634176013186 -0.0222170383488091 0.94852054279305 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AFAP1 -0.077034814775073 0.746966175716176 0.919189349632913 0.136415309833113 0.574410563917356 0.829180576133366 0.416844987783197 0.246213051974469 -0.989165346502487 0.0094156770833258 -0.57232035871929 0.0945653090436783 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GDI1 -0.0874633285497165 0.747153817236981 0.919189349632913 -0.105594512352059 0.69626816422486 0.888447116319334 -0.200273331347569 0.639725858041791 -0.907241610032576 0.0197701245451795 -1.10751494138014 0.0115374566040419 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTOR -0.0436063439046425 0.747421732424769 0.919189349632913 -0.0740556253257642 0.583852749642429 0.834132995585234 -0.149042885600037 0.596763557977077 -0.235823336542411 0.297124022884612 -0.384866222142448 0.113274299833854 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIAA0825 0.047800836189818 0.747448739699973 0.919189349632913 -0.0539021811966253 0.713199299041571 0.895497343705388 False False False False False False False 0 insufficient_or_context_specific +AGT -0.136823762525519 0.747537098253949 0.919189349632913 0.0231679860366574 0.957249192833802 0.987656798648419 -1.04102325458345 0.0572592820937919 1.14893231810562 0.0283761772708502 0.107909063522165 0.846072794634436 reversed False False False False False False False 0 insufficient_or_context_specific +C19ORF18 0.120839165773252 0.747690183819155 0.919189349632913 -0.456821909794607 0.223005651736089 0.593969140017564 False False False False False False False 0 insufficient_or_context_specific +PDLIM1 -0.0873839973783155 0.747936216941405 0.919189349632913 -0.478112719820583 0.0768336932781461 0.455668688469891 0.9867126624837659 0.9647415720342751 2.0 0.0213257282167891 0.948415356036059 0.30497627091463 0.166359108510039 0.32630199913142 0.158659955264833 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ICE1 -0.0447372795649316 0.747948466908074 0.919189349632913 0.0459067151046851 0.747161684832399 0.909830759894547 1.11398147200728 1.0 -0.226634138526512 0.42188766663656 -0.431798744655087 0.0807983658700729 -0.658432883181599 0.0223943275551858 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01091 -0.0807900278692213 0.747967493976012 0.919189349632913 -0.0994680832366836 0.693323873313961 0.88707143170732 0.46541458982395 0.296094004861832 2.0 False False False False False False False 0 insufficient_or_context_specific +CFAP161 -0.133821309734342 0.748041426630009 0.919189349632913 -0.509718384383603 0.19470833829689 0.571343735852293 False False False False False False False 0 insufficient_or_context_specific +RTCA -0.0842658788393778 0.748064718472583 0.919189349632913 0.159975649916945 0.552990198177134 0.819071644755648 0.0236112724716092 1.0 -0.556582891727474 0.16123287744864 0.514957686264127 0.128732653862785 -0.041625205463347 0.921340635653772 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PROSER2 -0.0847396685709907 0.748295910931539 0.919189349632913 -0.291791394742647 0.260192737985268 0.622928555022326 -1.29175916948248 0.046943280793973 0.555247545435516 0.317031856385773 -0.736511624046965 0.192919618084115 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HSF2 -0.0966313651945099 0.748374698521384 0.919189349632913 0.138590024996923 0.651854817933024 0.870123466781337 -0.0568140384876442 0.885896209712577 -0.177108033196377 0.516655725454482 -0.233922071684022 0.423181073170862 partial_or_other False False False False False False False 0 insufficient_or_context_specific +THUMPD3-AS1 0.0817998223183781 0.74848799985002 0.919189349632913 0.346041537670489 0.175206292001239 0.557192294943862 0.133239747632047 1.0 True False False False False False False 0 insufficient_or_context_specific +PPP6C -0.048621887992701 0.748526929486417 0.919189349632913 -0.0399738248935621 0.792199930333674 0.927620871373898 0.38844016971014 1.0 -0.113869198969508 0.668694067676721 0.118386757691982 0.571332506724507 0.0045175587224746 0.986587937636656 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SP140L -0.0521154566482954 0.748549917422219 0.919189349632913 -0.162329614735522 0.290770697507706 0.650001487250975 False False False False False False False 0 insufficient_or_context_specific +LYRM7 0.0797576837324405 0.748754802695994 0.919227117077244 -0.0071751977996284 0.976700265778509 0.992970766113577 -0.0561080901493324 0.955118715781651 0.447184933857721 0.437295603101296 0.391076843708389 0.57732948182281 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDE4D 0.093840252708502 0.748986521139807 0.919404684361595 0.255826995829012 0.374857226992979 0.712838905321506 0.666648540529693 0.457346746136831 2.0 -0.487116602695832 0.217411387804926 0.379936114720855 0.244076406152203 -0.107180487974977 0.785587231532416 partial_or_other True False False False False False False 0 cross_species_direction_conflict +METAP1D 0.0656549888915995 0.749303623420655 0.919687009541418 0.133553205017079 0.518869102095458 0.800840369846825 -0.402730870535545 0.161462503584089 -0.415752952994163 0.10884005235198 -0.818483823529707 0.0116867189697517 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NGF -0.166146184759604 0.749402946009994 0.919701999764445 -0.149875328469905 0.773583634343789 0.921597905470986 0.303169218914446 0.345742658297151 2.0 -0.160292482574372 0.675926385250434 0.119954297703966 0.704784050604652 -0.0403381848704063 0.913419053532141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TFEB -0.0985932698729914 0.749556758856546 0.919720399672202 0.0709617307777185 0.81873148186481 0.937443551190615 0.6316539408592521 1.0 -0.726712629329181 0.0444728499089607 0.361326405893886 0.232317487149235 -0.365386223435295 0.251615726365561 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZDHHC1 -0.0925425070493939 0.749690845655339 0.919720399672202 -0.159938120687771 0.58245063164545 0.833494998054781 0.199591624037568 0.573999128119109 -0.373652578664999 0.186680018338252 -0.174060954627431 0.584439106486517 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LMBR1L 0.086285682802746 0.749778223421326 0.919720399672202 0.0397791675429731 0.881746856402152 0.962618478946739 -0.371766344201914 0.412448068065036 -0.318928483612904 0.410024142991999 -0.690694827814818 0.0982475957711786 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NUCB2 -0.0921461170010672 0.749804542066202 0.919720399672202 -0.0583524639912371 0.840087850193253 0.94872687157347 0.12903634449556 0.812840616802995 -0.90173863712148 0.0358341438059579 -0.772702292625921 0.0798648203312003 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS22 0.107988300687763 0.749922118879206 0.919720399672202 0.451214959085682 0.193737664218978 0.570885363891703 True False False False False False False 0 insufficient_or_context_specific +PCGF2 -0.0904957702204355 0.749970909363216 0.919720399672202 -0.0971788792777847 0.73230077939377 0.904431845923655 0.228766603390883 0.475962003017413 -0.676025993589942 0.0224281951828821 -0.447259390199059 0.123709383048815 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1ORF131 0.0856233005702668 0.750027717482256 0.919720399672202 -0.0663168751246114 0.807238437334447 0.932788199072101 0.0408281288706258 1.0 False False False False False False False 0 insufficient_or_context_specific +AC078846.1 -0.153895427060856 0.750510817827893 0.919855385136123 0.0818363372336193 0.865651745346606 0.958391272020028 False False False False False False False 0 insufficient_or_context_specific +FARP2 0.0529784978062525 0.750590251713056 0.919855385136123 0.0470180468129326 0.77750808810805 0.922929913000972 -0.54543197295338 0.093505689492817 0.535628306401649 0.0631027379832014 -0.0098036665517311 0.978768022768344 reversed True False False False False False False 0 cross_species_direction_conflict +FGFR1OP -0.0805931062983716 0.750662326067475 0.919855385136123 -0.0451589635166632 0.859286378415559 0.956914759994669 -0.019129310368019 0.965260864033236 -0.162260911538392 0.588396614941279 -0.181390221906411 0.585208634841058 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP1B3 -0.227384840570465 0.750705500862541 0.919855385136123 -0.608407990910303 0.394809049871804 0.726080478554543 0.191241772492907 1.0 0.239377416073748 0.501247506689022 0.173371400536674 0.550251792313442 0.412748816610422 0.181678224446525 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM46 -0.260816397129879 0.750772628858227 0.919855385136123 -0.300919711927776 0.714849732580591 0.896896432155185 1.25629454649036 0.0108618862204697 -1.07675701808551 0.011607751173525 0.179537528404855 0.707829354093994 reversed False False False False False False False 0 insufficient_or_context_specific +UBA7 -0.131516026545626 0.751022692152413 0.919855385136123 -0.038614184658658 0.926197654514711 0.978760367967803 0.4679761872106671 1.0 -0.476387821643349 0.253452962506105 -0.854235002723101 0.0345773762608904 -1.33062282436645 0.0074677287896866 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PSME4 -0.0507674618211166 0.751047024023353 0.919855385136123 -0.0305477475287808 0.847774041027974 0.952893503643581 0.0929868932126361 1.0 0.054203848798553 0.86139670882348 -0.250284450075512 0.245837261092544 -0.196080601276959 0.397419841176356 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PACSIN2 -0.0860871050443537 0.75119581054061 0.919855385136123 -0.299333799196617 0.276599016762745 0.639769922987698 0.502417782153574 0.0614728474807179 2.0 -0.165173693875192 0.546256066414921 0.166161884709335 0.454789248965598 0.0009881908341438 0.997473242852981 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PAK2 -0.0557741856535517 0.7513157936322 0.919855385136123 -0.0485869500212029 0.781853765046022 0.924647355053618 0.268190762526595 1.0 0.0825684266904793 0.824549485756112 0.133785694966656 0.612661579609855 0.216354121657136 0.440775792737037 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OSTM1 -0.0855143090488478 0.751357533757712 0.919855385136123 0.0424636440068598 0.877539584265345 0.96120582328805 0.0815732893391761 0.857218206831363 0.397717875713027 0.181346342106623 0.479291165052203 0.147168510660946 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF90 0.104818338532966 0.751534266108382 0.919880721988694 -0.233606707377803 0.468736852324162 0.77300007678605 False False False False False False False 0 insufficient_or_context_specific +ZNF552 -0.0920689537228893 0.751552482276423 0.919880721988694 0.20909564211521 0.448171024996065 0.762454025444481 0.0195882194065923 1.0 False False False False False False False 0 insufficient_or_context_specific +EDEM1 -0.0702379349934838 0.752111036319843 0.919922577799954 -0.108988079416391 0.622858341503416 0.855086546711008 0.115432618396113 1.0 -0.499966159649993 0.191433240261074 -0.0681795373882924 0.858631752506243 -0.568145697038285 0.113718054790355 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHAF1A -0.137636076614562 0.752205134091942 0.919922577799954 -0.393312151385124 0.35984828249847 0.702743831320045 0.273110395280109 0.3822361073564339 2.0 1.91183257619024 0.004421621995063 -1.94100673414976 0.0022488372203741 -0.0291741579595245 0.970079951115289 reversed False False False False False False False 0 insufficient_or_context_specific +CDKL5 0.0588082563137076 0.752291399425455 0.919922577799954 0.0041586463980072 0.982196394662125 0.99451887511202 0.349320789131728 1.0 -0.300303727307656 0.545126921762246 0.154419118173269 0.701877835664097 -0.145884609134387 0.752513714186864 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RCL1 0.109210628387611 0.752351792422752 0.919922577799954 0.114888879466969 0.740120679434551 0.908274440555399 -0.778756852885597 0.0189989535658204 0.896573863949397 0.0066531087124478 0.117817011063801 0.695108397615421 reversed True False False False False False False 0 cross_species_direction_conflict +CARS2 0.0441880594978589 0.752401350407638 0.919922577799954 -0.0918118362048745 0.510995808081325 0.796519013040946 0.0370968489719783 0.904135391989346 -0.455943688772735 0.0420866617291221 -0.418846839800757 0.0712497957612434 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADNP -0.0428588832483663 0.75254037766928 0.919922577799954 0.0671645424913802 0.620829423558231 0.85421549797896 0.396880271419901 4.31586710281096e-05 2.0 0.277466479718315 0.256826093464707 -0.0796717748195408 0.720045502903935 0.197794704898774 0.379631111318528 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPA 0.0711891338099986 0.752545113132999 0.919922577799954 -0.182723811001292 0.385529391483199 0.719960311595735 0.359477129793488 0.261085878641705 2.0 0.315412049154125 0.200304406994427 -0.38808752767857 0.080304860507502 -0.072675478524445 0.773992188706357 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GNG7 -0.117730215275359 0.752912487903002 0.920226197659368 -0.408728477587742 0.250948423560456 0.617713036519484 False False False False False False False 0 insufficient_or_context_specific +DFFA 0.0740662804084141 0.753042557794659 0.920226197659368 0.0287002469839871 0.902463653581078 0.968997068204645 -0.363684263167621 0.384166755508118 -0.318664217260536 0.36845601818214 -0.682348480428157 0.0836848617814314 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF777 0.1134633838651 0.753159557440228 0.920226197659368 0.0221229798754734 0.951156540737137 0.986917609553614 True False False False False False False 0 insufficient_or_context_specific +SRM 0.115271879489982 0.753183583266527 0.920226197659368 -0.026231106503475 0.943248207054472 0.984366565940656 0.479858708385728 0.518605283623926 2.0 0.268549991340519 0.599633835023936 -0.112121287585865 0.788976475047182 0.156428703754655 0.740815043154523 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNTN3 0.0987504191819545 0.753229285865908 0.920226197659368 -0.137656518543608 0.657610605045583 0.871691185476023 False False False False False False False 0 insufficient_or_context_specific +PRDM4 0.0747370499474765 0.753810636395178 0.920374733045188 0.0775847211329792 0.744865480127574 0.909500945159707 -0.102481990163825 0.805647983937196 -0.331261696124724 0.257157797505311 -0.433743686288548 0.181898032853241 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MIER2 -0.0831561221268774 0.753932187176314 0.920374733045188 -0.117719387260253 0.657574832886677 0.871691185476023 0.7832072941935301 1.0 0.0747991822508244 0.832062370167634 -0.660286922443609 0.0192139814443205 -0.585487740192785 0.0425665157431516 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NRG2 0.138489897059618 0.753967611861014 0.920374733045188 0.385334377659053 0.38872586683349 0.721906173483826 True False False False False False False 0 insufficient_or_context_specific +SFXN4 -0.116583014978769 0.754059360929583 0.920374733045188 -0.186781318984819 0.614639388377316 0.851202504312702 -0.227141939855164 0.717461163046346 -0.11469625793793 0.822511667978687 -0.341838197793094 0.51700803469338 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM71F2 -0.161123460645681 0.754353042882063 0.920374733045188 -0.198158735874702 0.698412073163707 0.889371148052465 False False False False False False False 0 insufficient_or_context_specific +LINC02001 0.0937851328312941 0.754498643350871 0.920374733045188 -0.122780418203043 0.676084741841074 0.879076687728825 False False False False False False False 0 insufficient_or_context_specific +KPNA6 0.043055974992979 0.75450888533904 0.920374733045188 0.0225242747425512 0.870228358715805 0.958502690861149 -0.17997241469078 0.634515478880891 0.247142403496283 0.39561140610665 0.0671699888055026 0.850646526851807 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RNF44 -0.114136164109952 0.754571290892133 0.920374733045188 -0.20552860323687 0.569431763178726 0.825719070957423 0.278250200095497 1.0 0.0092717739509754 0.979995535439195 0.10322031920628 0.687653492457427 0.112492093157256 0.685283581522697 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BCAT2 -0.120045826586103 0.755451469956284 0.921312607809559 -0.265543100147725 0.487093620424977 0.782147598778917 0.462115833360539 0.0577341657013748 2.0 -0.37770321172082 0.126318569851417 -0.391966110822056 0.0816589234195652 -0.769669322542875 0.0077981511249726 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTCH1 0.140528013767586 0.755514733701001 0.921312607809559 0.269936424024502 0.548327974255287 0.816156774016399 0.26404507750602 0.7093212152564471 2.0 -0.132637159564817 0.657867510448794 0.106128977975164 0.661270568117103 -0.0265081815896527 0.927489221408977 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DEAF1 -0.062106908803071 0.755693545424293 0.921373722578013 -0.0195967114281302 0.921609576810733 0.976943163852181 0.323362363736261 0.221094369266366 -0.82612832502076 0.0053240027283418 -0.502765961284499 0.0545071944201788 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC245140.3 -0.223286605241891 0.755792331257838 0.921373722578013 -0.573157603485102 0.385619962310464 0.719960311595735 False False False False False False False 0 insufficient_or_context_specific +ZUP1 -0.0926433197816626 0.755902144612288 0.921373722578013 0.0775137100325239 0.796253155393757 0.928812397200087 -0.0050367672386277 0.992862411288349 -0.422629025568175 0.236797176508207 -0.427665792806802 0.265732256325115 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF43 0.0640960924432893 0.755913921668 0.921373722578013 0.156215424046014 0.44450525947153 0.759994423711047 True False False False False False False 0 insufficient_or_context_specific +SMIM12 -0.0819382614827411 0.756037256621177 0.921417679257346 -0.330927783863565 0.192303594152981 0.570885363891703 -0.136807616359208 0.648410825232897 0.216457771283087 0.350339468685738 0.0796501549238789 0.77039970103489 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MED13 -0.0389216770122746 0.756176056571341 0.921480471523571 0.0712983811354312 0.573443973502369 0.828262182515527 0.282555632268675 0.108633203502306 2.0 0.0963740978457205 0.707828152624471 -0.0117645624866676 0.959452791477171 0.0846095353590529 0.70983486516815 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOXA1 -0.151283816393576 0.756364083442298 0.921603230580933 -0.183530510894881 0.707085405280338 0.893280888368658 0.997233163035965 1.0 False False False False False False False 0 insufficient_or_context_specific +KIAA1958 0.0829193114967982 0.756461781699731 0.921615911745415 0.292741380951076 0.263479325934614 0.626379950271573 0.0529263519509837 1.0 True False False False False False False 0 insufficient_or_context_specific +SCD -0.151868549897337 0.756971956728429 0.921985228969995 0.0239215654986941 0.960836275203898 0.98903279649047 False False False False False False False 0 insufficient_or_context_specific +DDHD1 0.0665576634786802 0.756987422758371 0.921985228969995 0.307032072914054 0.148207406596203 0.533506238950805 -0.0088665125757064 0.978775837181156 -0.738808603388927 0.0076195310780943 -0.747675115964634 0.0109886815635963 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC048341.1 -0.0850714142016011 0.757026894292563 0.921985228969995 -0.0343437524850525 0.901007214300781 0.968227396293907 False False False False False False False 0 insufficient_or_context_specific +KAT2B -0.0526180101149888 0.757225488600252 0.922080225753427 -0.153105523322732 0.346632793725811 0.691824014396429 -0.372591739329475 0.610573234533361 1.12419199901969 0.0413790698838906 0.751600259690219 0.185197991941694 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BFAR -0.0567765674204616 0.75727956407539 0.922080225753427 0.066978862086302 0.712303712902565 0.895497343705388 -0.365290950695608 0.173080457939863 -0.270151342685902 0.24943614604125 -0.63544229338151 0.0241449864711933 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OGFOD3 -0.0628685561661709 0.757572462075105 0.922315005156462 0.09638143732439 0.631828657380527 0.860199479641986 -0.072932732585242 0.922603819289352 0.183567066172102 0.712448583275869 0.11063433358686 0.85463750511781 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GRAMD1A -0.0623748208868917 0.757647096014586 0.922315005156462 -0.059740938839888 0.767458567912859 0.91954879692023 0.5991099957257939 1.0 0.615236834926796 0.0385908394070961 -0.900724112978861 0.0052531331014699 -0.285487278052066 0.290479499497752 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF710 -0.0584216746773366 0.757748491246467 0.922332092527116 -0.006172624648146 0.974035273719823 0.992450915625761 False False False False False False False 0 insufficient_or_context_specific +PSMD13 0.0739189155804218 0.75791051824367 0.922422968486071 0.470247776562083 0.0639835577252437 0.433423054966818 0.0149842446995851 1.0 -0.129368535661665 0.645649969558987 0.245589656543866 0.262722840691246 0.116221120882201 0.637311826384501 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ITGB8 -0.156046469022645 0.758777895990185 0.923265763036116 0.114637365863398 0.827100730275342 0.942259214105446 -0.193761216209817 0.77654122523999 0.437026161189718 0.358820337103898 0.243264944979901 0.663198552328506 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XRCC6 -0.0358884188159814 0.758939764907883 0.92335630766276 -0.0606939813585404 0.602214127617979 0.844662020693454 0.322921126861365 0.50761556665693 0.246089406952257 0.496391175839789 0.569010533813622 0.172707733363931 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRR5L -0.121071967617637 0.759124122603779 0.923474189013792 -0.0224916151133966 0.954534537613505 0.987410276805219 -0.0302566686709967 0.962783478518733 -0.278716886519645 0.505501453732661 -0.308973555190642 0.529096075306914 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WBP1L -0.0559441455729719 0.75930286596782 0.923474587750447 0.0083291561864033 0.963932748843466 0.989935386867005 0.580026316610253 0.812844522120289 2.0 -0.55941506864715 0.191473708231911 0.474054130986564 0.210088397436637 -0.0853609376605868 0.848856992637175 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZMYND8 -0.0708763325199932 0.759348417795274 0.923474587750447 -0.465422909169022 0.0192288624702986 0.330467462546779 1.04806643126103 1.0 0.0824071917821263 0.821224349428667 -0.588961400470053 0.0383543314302739 -0.506554208687926 0.0793934465329941 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CEP76 -0.0954192432385753 0.759828176207722 0.923589552317505 -0.0977149654104517 0.754344390975703 0.913618862571469 0.457295242447901 0.372867518414602 -0.320556874530654 0.420595399064612 0.136738367917247 0.795338169129093 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL7 0.108315462656097 0.759831201179615 0.923589552317505 0.0049823169700663 0.989916122962305 0.996896452948454 True False False False False False False 0 insufficient_or_context_specific +GPR155 0.0783315470226977 0.75991446064016 0.923589552317505 0.232346510740964 0.355239319058418 0.698568957090478 -0.394746925245616 0.508847535439478 0.812515071723271 0.0815339889259068 0.417768146477654 0.398149839503171 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC02197 -0.143833211613415 0.760913907883318 0.924419521777892 -0.194171073275794 0.679916611283266 0.881021058165038 False False False False False False False 0 insufficient_or_context_specific +ZNF589 -0.0999412034943656 0.761152291244277 0.924419521777892 -0.330844718913114 0.307218241478236 0.661701213710167 0.6732924920551109 1.0 False False False False False False False 0 insufficient_or_context_specific +LDLRAD3 -0.11087797904017 0.761264171626914 0.924419521777892 0.255709632033672 0.484209136020915 0.780739165868788 0.0605689098042645 0.893521538426301 -0.401437893894965 0.186906210764851 -0.3408689840907 0.308373657749842 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMTN 0.0951513605149888 0.761485958692898 0.924419521777892 -0.251839541715668 0.42225439872621 0.744019015646082 0.364493516646057 1.0 -0.23763637337442 0.604968023577395 -0.628148126938597 0.100182473690157 -0.865784500313018 0.0397746564415796 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHURC1-FNTB 0.0970844189463238 0.761503572771829 0.924419521777892 0.13692279298409 0.669398763385338 0.876101666520689 True False False False False False False 0 insufficient_or_context_specific +LINC02516 0.128132322003744 0.761557720910086 0.924419521777892 0.325526640089319 0.443284595226521 0.759156327072443 True False False False False False False 0 insufficient_or_context_specific +C7ORF26 0.0710915256894785 0.761600991047271 0.924419521777892 -0.114097858425631 0.617450342276275 0.85250682148546 False False False False False False False 0 insufficient_or_context_specific +ACSM3 0.158057469560508 0.761818644820159 0.924433579099978 -0.368314629022008 0.476196556981684 0.777939354595146 -0.821414170923118 0.170225743737497 1.56115154224272 0.0097873514076932 0.739737371319599 0.160057180788343 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADAT1 -0.0759793266766953 0.762043101530959 0.924433579099978 -0.0628888104415345 0.802319209186059 0.930804158304986 0.0608110697105471 0.871083902089151 -0.58473096837739 0.0376977103563931 -0.523919898666843 0.0761110811469107 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCF7L1 -0.0581207077929019 0.762068662198754 0.924433579099978 0.0226477296799281 0.905373478770603 0.970253064236706 -0.0783705991982086 0.816147885963 -0.675999260725137 0.0162003156555855 -0.754369859923346 0.0149200055406564 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VAPB 0.0459147309647828 0.762213740436176 0.924433579099978 0.100144378020342 0.513098980806992 0.798308503171783 -0.0116507655024184 0.968885345507662 0.076420091001954 0.718563392414516 0.0647693254995356 0.784466051590018 partial_or_other True False False False False False False 0 cross_species_direction_conflict +THRA 0.0944606968155087 0.762313453495796 0.924433579099978 0.220779698955186 0.489472018906687 0.78407610007841 1.12914682807321 1.0 -0.191973800327028 0.482181300221052 0.135471258791352 0.551636727994254 -0.0565025415356756 0.83408148059749 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CNOT10 -0.0473839519903656 0.762367872969447 0.924433579099978 -0.0797870912749864 0.609091186316982 0.848013066172034 0.079286164002653 0.817126893380336 -0.140400765498022 0.577759657724586 -0.0611146014953687 0.836988632285481 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USB1 0.105053887166178 0.762539499941439 0.924433579099978 0.44533565637311 0.215066136776564 0.587852789707652 -0.0654418181388446 0.887380605155132 -0.0403085592193545 0.910443758390551 -0.105750377358199 0.777672869717547 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TET1 -0.108156579047475 0.762727970835978 0.924546245286789 -0.102550701081131 0.774818774876283 0.921907331897703 0.58457887590525 0.611236779183492 0.608903766956529 0.380793062903813 1.19348264286178 0.188385490834727 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MGAT1 -0.0790977102609222 0.762940910767411 0.924601714403389 -0.0557932030409097 0.832603689182523 0.944822630093409 0.0494209177625811 0.888246105077982 0.0770082950436386 0.767115178773898 0.12642921280622 0.641220781461288 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCNIP1 0.178277489730138 0.763123766178877 0.924611053857767 0.241119896374629 0.685003718197679 0.883169000123458 True False False False False False False 0 insufficient_or_context_specific +PAICS 0.0909253868291967 0.763288152708653 0.92469397731599 0.196905202335025 0.515588036536032 0.799350732708873 0.0254549940491683 1.0 -0.0791316731787147 0.906931604824601 0.865240171286223 0.0562832681738424 0.786108498107508 0.100441257201587 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRIM65 -0.0785438986198807 0.763467025116862 0.92469397731599 0.0302456651751412 0.907120907751205 0.971275673886815 0.234124441248989 1.0 -0.0838249947687037 0.825890531343763 -0.38879826163081 0.154061136962931 -0.472623256399514 0.107840726521488 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RGS11 0.0984526199161759 0.763918818815404 0.924937487276724 0.177920302533642 0.587616689512676 0.835274227991216 -1.30977186637803 0.115478656376494 -0.941097076045052 0.276707199013225 -2.25086894242308 0.0211750672959938 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF429 -0.0725564608920378 0.764463077379745 0.925339482742438 -0.218089876725126 0.351360283065437 0.695960310851161 False False False False False False False 0 insufficient_or_context_specific +SUMO1 -0.0464435072543144 0.76483965358067 0.925422719084667 -0.13397534410295 0.367316649351398 0.708317354196916 0.0029092397534089 0.994302327353405 0.252505630767137 0.322735225741053 0.255414870520546 0.355449604460031 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POGK -0.0725802679025736 0.764845486525176 0.925422719084667 0.0237635913176291 0.922885484335568 0.97777552504144 -0.547460794521545 0.170205026279358 -0.279713608069297 0.427770563524525 -0.827174402590842 0.0400325339094177 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCNT2-AS1 -0.0970592352835833 0.765012965459809 0.925519295213093 -0.190873094811702 0.553973574842213 0.819759396393367 False False False False False False False 0 insufficient_or_context_specific +DRAM1 -0.0873942878434933 0.765686824165097 0.926228401642426 0.0609648052307638 0.836107213742276 0.946966312238892 0.867264334301413 1.65446294001035 2.0 -0.685983200810487 0.415382455534496 -0.918136697321015 0.230198285354586 -1.6041198981315 0.0602498035493273 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF445 0.0514554204294707 0.765909329250178 0.926321532121713 -0.173454898184141 0.335532534080534 0.684461073909613 False False False False False False False 0 insufficient_or_context_specific +MIR503HG -0.152817529625904 0.766031267258561 0.926321532121713 -0.714284873054548 0.145799001214885 0.532658823056677 False False False False False False False 0 insufficient_or_context_specific +WDR20 0.04912226741682 0.766152917428944 0.926321532121713 0.0316398473058464 0.847164247402549 0.952541014278606 -0.0507951207556198 0.910657294148097 -0.220179896766702 0.469416671005716 -0.270975017522321 0.405317018152631 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF354B 0.0599607232136128 0.766207386791799 0.926321532121713 0.103639840504475 0.6065068733981 0.846931578987574 0.402264532917295 1.0 True False False False False False False 0 insufficient_or_context_specific +SMYD2 -0.0621144325478995 0.766238466497982 0.926321532121713 -0.110942707729595 0.592667064829732 0.838902274600198 -0.177873122552083 0.598877486969886 -0.347004335482141 0.202194596211444 -0.524877458034223 0.0794170333570016 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP5F1D 0.101084384241584 0.766391001245671 0.926321532121713 0.291545953634683 0.39847402749116 0.728878860403963 0.0197090783736961 1.0 True False False False False False False 0 insufficient_or_context_specific +AC124319.2 0.0609196932380467 0.766432962689454 0.926321532121713 0.0646352611360632 0.75250010459721 0.912996564506704 True False False False False False False 0 insufficient_or_context_specific +PLS3-AS1 0.163635329096836 0.766465704168904 0.926321532121713 -0.374966477715244 0.475681859935062 0.777735491146475 False False False False False False False 0 insufficient_or_context_specific +SLC19A2 0.179835537132992 0.767113090735948 0.926736707347902 -0.242082211070049 0.689273674978983 0.884999569552245 0.0385935719541561 0.888569713961028 0.042789108200192 3.0 -0.590659162353537 0.0647319282805759 0.687742747014761 0.0233695746073517 0.0970835846612247 0.758275847149118 reversed False False False False False False False 0 insufficient_or_context_specific +SESTD1 -0.0469824423112525 0.767160335501105 0.926736707347902 0.0188305224495563 0.904779406296223 0.969884267885983 0.54806216315282 0.268302181913368 -0.874563149245638 0.0456711702517288 -0.326500986092818 0.506329181663609 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NEDD1 0.0502429021770949 0.767325825697676 0.92677135653674 -0.0655569707305752 0.677253232555741 0.879729285103778 -0.0329208295806514 0.944288862402185 0.0308475600861576 0.931146349955999 -0.0020732694944938 0.996346666362738 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEMA6C -0.144804863556707 0.767618121516616 0.92677135653674 -0.341895196713917 0.472753330801405 0.775593712997022 0.133785904665536 0.766315434517561 -0.10715794648525 0.766965481751459 0.0266279581802865 0.948791558498088 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUFIP2 -0.0543328908548882 0.767627782998662 0.92677135653674 -0.013136519031405 0.942613773073643 0.984366565940656 0.194868780065568 1.0 0.477125202935987 0.0825325412998333 -0.120501287522927 0.618744978573252 0.35662391541306 0.160995685848001 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPX4 0.0894135961926177 0.767720118512689 0.92677135653674 0.596812392484912 0.028998330086868 0.369232614592462 0.986941614249695 1.0 True False False False False False False 0 insufficient_or_context_specific +PPM1F 0.080392348784742 0.767942740376857 0.92677135653674 -0.269106142670432 0.305732767014687 0.661696690217148 0.188168423484335 0.688936764998849 -0.265318229701562 0.457523308087439 -0.0771498062172262 0.862977363528353 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAH5 0.215340895535697 0.768180604608798 0.92677135653674 0.0733537546957239 0.918668487867431 0.975930957742715 True False False False False False False 0 insufficient_or_context_specific +KAT7 0.0544135395836781 0.768506929590569 0.92677135653674 -0.17254622043299 0.304204518079311 0.661341495477036 0.540859570288133 0.6478712875652621 2.0 -0.0755023959547835 0.817126893380336 -0.0494082005041111 0.848852618790794 -0.124910596458895 0.6351603677909 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AKAP9 -0.0416914491884869 0.768527602650917 0.92677135653674 -0.107449289324921 0.437670330834165 0.754559659201031 0.115587174824536 1.0 -0.0677888614195911 0.82439469301198 0.0036534458319074 0.988937394284849 -0.0641354155876836 0.801846654427446 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATG5 0.0640806765064561 0.768535445255561 0.92677135653674 0.144828502542779 0.503440881690204 0.792478940884811 -0.439567138984977 0.164787972069722 0.358179302451962 0.187734333909864 -0.0813878365330149 0.799661631189171 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DROSHA -0.0585893911324395 0.768579212037438 0.92677135653674 0.204542625231654 0.317421717027954 0.669290253214092 0.0905165860238441 0.857278928161787 -0.118724629246903 0.740183269678737 -0.0282080432230585 0.948416476928023 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC107 0.103182735991531 0.768628428697439 0.92677135653674 0.189566385018288 0.592133345716527 0.83882246935128 0.491586556014786 0.612143504232681 2.0 -0.313366577262034 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False False False False False 0 cross_species_direction_conflict +TPP2 -0.0504651537712928 0.768856820600996 0.92677135653674 -0.0685748061810086 0.687886651090778 0.884546784138472 0.0699715997044469 0.853490782058691 -0.0749008950169502 0.791939505073795 -0.0049292953125032 0.988314184511743 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC009061.2 0.0913985184235463 0.768951637947446 0.926779839434832 0.223120869725122 0.47008184886105 0.774115985605889 True False False False False False False 0 insufficient_or_context_specific +GSTZ1 -0.112953213978131 0.769263432325762 0.927049802362218 -0.386626073618732 0.312492542290274 0.66477861404407 -1.0894376197942 0.0131258533488617 1.5090506871221 0.0025879778974656 0.419613067327898 0.253728124196861 reversed False False False False False False False 0 insufficient_or_context_specific +NRF1 0.0383798375372109 0.769743499212114 0.927299639143443 0.0877283014323248 0.501771931020437 0.791343381621299 -0.103060048169155 0.758590605568299 -0.0217309587701772 0.93926748787036 -0.124791006939332 0.65913666943703 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IKZF5 0.0743121765297918 0.76987608932626 0.927299639143443 0.0287925977173424 0.908960563970845 0.971465990561519 0.0479734941507392 1.0 -0.338878450376079 0.185091270678526 -0.0119066723852663 0.963612204654247 -0.350785122761346 0.141391011251308 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAN2A1 -0.057155952838123 0.769897593020621 0.927299639143443 0.0240566347768532 0.901493551879479 0.968514302139562 0.323740867926732 0.558615738878792 2.0 0.0224934003821158 0.965542061567004 0.338110216336317 0.345248676098201 0.360603616718433 0.335458803280165 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CALD1 0.0707594969640748 0.769909891715422 0.927299639143443 -0.112109193613782 0.635276780847441 0.861847932958146 0.832703562173149 1.19853377180404 2.0 0.531127076717791 0.0806805283714422 -0.19957577872005 0.456526363617618 0.331551297997741 0.233977018844893 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARSG 0.103530550160048 0.770033207991111 0.927342375951882 0.140347182467844 0.694368825499059 0.887432585446834 0.0279597808517096 1.0 -0.316434889183743 0.602336793198419 0.0014767963020626 0.997861089730202 -0.31495809288168 0.553804150011251 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CLINT1 0.0421098312672863 0.770612524419452 0.92782954531663 0.105525582711721 0.468743660410649 0.77300007678605 -0.159637694721074 0.623281942230427 -0.139558461390405 0.600550132762128 -0.299196156111479 0.272848927507933 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MTMR10 0.0572356137956656 0.770613495253033 0.92782954531663 -0.0265907038684376 0.89045320305507 0.964713393362605 -0.496532406549219 0.325017572953707 0.529678767838076 0.192523825158799 0.0331463612888568 0.94852054279305 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNMBP 0.0641752757842736 0.771493464937048 0.92844249340499 0.198046394537581 0.382732329309986 0.718507811674046 0.0430120043853879 1.0 -0.737520093630603 0.0427621050133584 0.255982373018288 0.41131877403298 -0.481537720612315 0.142052474891757 partial_or_other True False False False False False False 0 cross_species_direction_conflict +STX2 -0.0643156224575177 0.771823403262792 0.92844249340499 -0.173798175784961 0.423054564285861 0.744310963127832 -0.173600228844083 0.614121189200058 -0.317939720437438 0.248324252807164 -0.491539949281522 0.0988115518376955 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MMP23B 0.11863538812982 0.771847108497133 0.92844249340499 0.250037230547463 0.545044069428119 0.81520013063734 0.2642923411581919 1.0 True False False False False False False 0 insufficient_or_context_specific +GANC -0.072699545100586 0.771952971923775 0.92844249340499 0.0118815561625214 0.962087662059462 0.989838387840947 -0.231638314479867 0.668879454695898 -0.015574788021493 0.974195173369082 -0.24721310250136 0.595332156027235 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITGAE 0.063902387775933 0.771964268658322 0.92844249340499 -0.020152942123134 0.92616896502578 0.978760367967803 False False False False False False False 0 insufficient_or_context_specific +GLRX3 -0.0560136857443933 0.771980493426505 0.92844249340499 0.135842621085677 0.46093456362122 0.768806812434888 0.894814623310726 1.0 0.152872902767505 0.706874408268827 0.14971505085785 0.632802046256331 0.302587953625355 0.36052116622825 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHDC3 0.0914733980036001 0.77204112770444 0.92844249340499 -0.0830791170503505 0.787388803548576 0.926370736334507 -0.0097215468444464 0.977260934134183 -0.0241939678580357 0.928541937519275 -0.0339155147024821 0.905691209127458 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNRF3 -0.0652424968924539 0.77234538853896 0.92844249340499 -0.019358286239661 0.931475565767368 0.980803732260085 0.631120159849865 1.0 0.44098645460118 0.218461766941618 -0.235494210476618 0.428802515744496 0.205492244124562 0.553397724125437 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRA2B 0.057056760354765 0.772364358131124 0.92844249340499 -0.148749726109024 0.459518310866194 0.768508526235589 0.38428800828998 1.0 0.312375660735459 0.261134999447614 -0.0419570972043263 0.874620752748553 0.270418563531133 0.288641450570805 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FSD1L -0.0761736968286632 0.772441642552513 0.92844249340499 0.239042491303458 0.373652143516989 0.711968837980936 0.474926331367229 0.493562823809985 -0.989767046627141 0.0810217742940934 -0.514840715259912 0.439305022137106 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CASP8 -0.0750025284813712 0.772750926116947 0.928502648135399 -0.171651312592234 0.506275380023326 0.793608039538775 -0.186181769420755 0.629072786176249 0.273133879647549 0.355113076188798 0.0869521102267932 0.807263673090137 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DTX3 -0.0628159631842206 0.77275551895868 0.928502648135399 -0.0320523117573796 0.882891455190812 0.962778177759102 0.101095390459394 0.840915112898908 -1.23354326069995 0.0063950802174883 -1.13244787024056 0.0131086841178374 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPM1D 0.0621627816985044 0.772977800886525 0.92866404435138 0.0091264262386577 0.966097928768312 0.990778235253603 0.3206551429289181 0.461881340861923 2.0 -0.0264192373449525 0.956488298731866 0.0372610002402568 0.919100420181174 0.0108417628953042 0.980088887108866 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SCART1 -0.0913439420448377 0.77366243563811 0.929205389921461 -0.0461978673909784 0.884794919604335 0.963081098449005 False False False False False False False 0 insufficient_or_context_specific +PSMD7 -0.070195943666101 0.773697938865387 0.929205389921461 -0.187664284539376 0.422889373723681 0.744144334629103 -0.179520371729562 0.471119257261521 0.288280371508167 0.165663631471311 0.108759999778605 0.636594114880455 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS21 0.0669163466020816 0.773924530837489 0.929205389921461 0.0620512872737214 0.789575657200352 0.927187163688279 0.332436018065036 1.0 True False False False False False False 0 insufficient_or_context_specific +BUD23 -0.064375679967338 0.773934554909924 0.929205389921461 -0.0307800677551663 0.890856031536936 0.964781821824492 0.0425131815907895 0.918740615133397 -0.206060332221721 0.462757880793655 -0.163547150630931 0.600785653253811 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMC3-AS1 -0.0781909323098909 0.773956449987624 0.929205389921461 -0.115027427159319 0.673725449569167 0.877738560778784 1.11936607297471 1.23353027358082 2.0 False False False False False False False 0 insufficient_or_context_specific +CPNE2 -0.0649731716210314 0.774074958735522 0.929242002766304 -0.195605142431665 0.38452619424907 0.719298323474503 0.426207780027571 0.32344584855107 -0.784945743441758 0.0427231982072787 -0.358737963414187 0.379881921891787 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TSNAX-DISC1 0.111405324171682 0.774933220675178 0.929955097054846 -0.0176179584533315 0.96362324692651 0.989935386867005 0.259574527822438 1.0 False False False False False False False 0 insufficient_or_context_specific +SS18L2 0.104612704742793 0.775380314532341 0.930313035920296 -0.326712409041457 0.348906426199648 0.694288655897113 0.225601199821527 0.399931984857637 2.0 -0.205314753807289 0.638414696119831 0.496468479155836 0.134506766919864 0.291153725348547 0.416629745247091 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EEF2K -0.0597219802737398 0.775415721757062 0.930313035920296 -0.110769396443038 0.592726805824319 0.838902274600198 0.742278405730021 0.5829918028760821 2.0 -0.122549581146256 0.731556142006226 -0.396763223735806 0.148114639420254 -0.519312804882062 0.0852945863227709 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SFXN2 0.081557333710998 0.775587460207372 0.930313035920296 -0.04790317274665 0.868955224930705 0.958502690861149 0.189558550093707 0.5194537249978389 0.0171170571864918 3.0 0.089050339940749 0.856733521003214 0.43150544208324 0.185780691364791 0.520555782023989 0.147753090778002 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPATS2L 0.0708572244446175 0.775827367858345 0.930313035920296 0.17438312361029 0.484083796178898 0.780666906162311 1.20340240070275 1.0 -0.530742547476258 0.214082877414911 0.315044167993342 0.39024080699676 -0.215698379482916 0.595139012396859 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARHGEF37 -0.125548890850296 0.775847892116054 0.930313035920296 -0.0834586093502527 0.850033330292812 0.953127856970211 0.475754779886771 0.631156792681935 2.0 -1.28829431007347 0.0593114880329689 1.24915918033559 0.0359512818918564 -0.0391351297378804 0.951105607161563 reversed False False False False False False False 0 insufficient_or_context_specific +LINC01239 -0.167863885409993 0.77584829335842 0.930313035920296 -0.880830275823053 0.127806940414389 0.510744010936834 0.538785007478406 1.0 False False False False False False False 0 insufficient_or_context_specific +TBC1D13 -0.0630843386822621 0.776280539450836 0.930725634285933 -0.0689220423613245 0.756336978620866 0.914440101763119 -0.252533463683719 0.42557524288983 -0.197554525604552 0.458471998259477 -0.450087989288271 0.117298105405805 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZSWIM7 -0.0614491806703152 0.776388108593353 0.930748910018011 -0.061741933397872 0.775238821130372 0.922042522642161 -0.624134133045764 0.316242351171033 0.995469311434152 0.0520773385631057 0.371335178388387 0.484753930752702 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRAF3 -0.0797811422793155 0.776527321748931 0.930810111605951 0.1454945308293 0.607273595634131 0.846972709287018 0.108530945257935 1.0 0.116186104071404 0.774267546969046 -1.19649634001154 0.0037510074301774 -1.08031023594014 0.0093422913357088 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC90B -0.0831458326611225 0.776635119761282 0.930833646774845 0.275251840910893 0.367858298935581 0.708317354196916 0.198467050106477 0.651898598887457 0.189533178813256 0.55904092769149 0.388000228919733 0.280751127244676 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITGA9 -0.0969282191773798 0.776726971059513 0.930838065884942 0.034691986571646 0.919428205226964 0.976030129318521 0.641650961213016 1.0 0.502383495713014 0.127252575967881 -0.71329647826207 0.0265330988034598 -0.210912982549055 0.498948051728217 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GDAP1 -0.0820316549268975 0.777383211644857 0.931098226417468 0.06482826635128 0.824701528192446 0.940911901302771 False False False False False False False 0 insufficient_or_context_specific +NEURL1B -0.0753206587276679 0.77740537529371 0.931098226417468 0.14779592687151 0.59847036643302 0.842680747516785 0.3723028712654679 1.0 0.936773109121552 0.0121320074228118 -0.667676676425553 0.0319904590034328 0.269096432696 0.408506477182248 reversed False False False False False False False 0 insufficient_or_context_specific +AC105285.1 -0.137052658307485 0.777458744555217 0.931098226417468 0.109965780608127 0.826289963282829 0.941936594352229 False False False False False False False 0 insufficient_or_context_specific +TIMM44 0.0775075354377019 0.777473192280394 0.931098226417468 0.0319394651789856 0.906941374047343 0.971243232294537 -0.226451314793305 0.377146454111319 -0.373809685930896 0.0964123159798481 -0.600261000724201 0.0229244181563757 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KRCC1 -0.0554591483464755 0.777696700375799 0.931260265687613 -0.070625507747937 0.718269196809673 0.898496799968868 0.0120011886110714 0.97100168852273 0.100148103013647 0.665122964155281 0.112149291624718 0.657217437410124 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCFD2 0.0618799003774656 0.77788598007498 0.931342340061418 0.30126912007909 0.163767773808848 0.544850245278 0.149871410151705 1.0 -0.473052723473144 0.177305145823911 -0.128479040959399 0.693051616711354 -0.601531764432542 0.0757705653910034 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IGFBP5 0.141832759914696 0.777941664804096 0.931342340061418 -0.567645792071502 0.187069336820874 0.56929178900529 0.53637390855829 0.6226195567915911 2.0 -2.52007289688698 0.01500907072042 1.51825133768138 0.0779146209898896 -1.0018215592056 0.232559859547989 reversed False False False False False False False 0 insufficient_or_context_specific +SFT2D1 -0.0512827299645489 0.778163932051574 0.931502811179197 -0.170435439456246 0.350758339701626 0.695476332769186 False False False False False False False 0 insufficient_or_context_specific +STK38 -0.0425070691226189 0.778276585739892 0.931532047641059 -0.0852659205402505 0.561745156025345 0.823291102966203 0.432303838882855 1.0 -0.368585874036126 0.149394353934129 -0.377550556246874 0.102234291175216 -0.746136430282999 0.010395894143059 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNAI3-AS1 -0.0993586622228396 0.778495146563799 0.931544631229313 -0.417172675039045 0.222505513279079 0.593397884800048 False False False False False False False 0 insufficient_or_context_specific +FLT4 -0.188392910989219 0.778632645510931 0.931544631229313 -0.460579745106925 0.483140020889864 0.780666906162311 -0.736253017233004 0.0424314040115215 0.36669407653773 0.232284281291996 -0.369558940695274 0.250805812535 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM120C 0.0531081917063583 0.778777654231518 0.931544631229313 0.101806518060251 0.588296223046709 0.835590841220889 -0.744344156608588 0.0735675907680753 0.118866511763092 0.756717508743207 -0.625477644845495 0.104842430815148 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CPS1 -0.195863903535658 0.778816486063757 0.931544631229313 -0.190633209405941 0.784777406105407 0.925694079063559 -0.724526307491359 0.292909890974265 0.954484630195437 0.119916304354851 0.229958322704078 0.735065265355837 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM178A -0.130119924277825 0.779096020073457 0.931741081587067 -0.128990439789878 0.781244647087736 0.924291907659381 False False False False False False False 0 insufficient_or_context_specific +CMTM6 -0.0594539263298564 0.779231417662021 0.931741081587067 0.0818169319996494 0.708275904606463 0.893638108503159 -0.333936416029945 0.313598228539085 0.720304723180659 0.0224545452524276 0.386368307150714 0.194546743898624 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFP36L1 0.0760356357219481 0.779252119162249 0.931741081587067 -0.0378079944027894 0.890518728140931 0.964713393362605 0.619841666485329 0.4287525562098571 0.106635589867879 3.0 False False False False False False False 0 insufficient_or_context_specific +CYP3A43 -0.253817455355486 0.77942462297708 0.931741081587067 -0.343640218326657 0.702500521194368 0.891573566867428 False False False False False False False 0 insufficient_or_context_specific +SLC1A5 -0.105199578671666 0.779503013960061 0.931741081587067 -0.317726050155734 0.397165211588666 0.728024800638387 0.227828615314543 0.705726107349112 -0.772371124252656 0.107003223661981 -0.544542508938113 0.275966703550732 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MEOX2 0.175619204889765 0.780268611552202 0.932313609287116 0.197765825806109 0.753939571756679 0.913618862571469 True False False False False False False 0 insufficient_or_context_specific +CNOT6 -0.0560215835825115 0.780435667167493 0.932313609287116 -0.0588702692532861 0.769376465057694 0.920253395046917 -0.471983478415619 0.145995221084061 -0.107229386184594 0.720666061989235 -0.579212864600213 0.0652964016955386 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUTM2A-AS1 0.126593261984171 0.780731856619179 0.932313609287116 0.421346786397349 0.354312163461366 0.698014991474228 0.0786403582889894 1.0 True False False False False False False 0 insufficient_or_context_specific +TGFBRAP1 0.0758983884351624 0.780898476824707 0.932313609287116 0.367883530407131 0.187881042461614 0.56929178900529 0.5990057959206021 1.0 -0.247966730841635 0.342720226913364 0.065325201255544 0.786241638006412 -0.182641529586091 0.443376247589594 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HSD17B11 0.103942532403795 0.780901057125107 0.932313609287116 -0.132926251522496 0.720438236624122 0.900057614752986 0.0188002143429676 1.0 -0.983945671361341 0.0578703776295225 1.56454497024257 0.0056769282626833 0.580599298881232 0.206124215150347 reversed False False False False False False False 0 insufficient_or_context_specific +AC007952.4 0.128750135275715 0.780949996927051 0.932313609287116 -0.719002340816003 0.0920520416457055 0.472460751419842 False False False False False False False 0 insufficient_or_context_specific +ATP6V0E1 0.05637172272007 0.780960556974357 0.932313609287116 0.0993702127056209 0.620541816333762 0.854153589708151 True False False False False False False 0 insufficient_or_context_specific +KIAA1551 0.0748764009979903 0.781193758739594 0.932437573046198 0.076031573460166 0.777911641014724 0.922929913000972 0.133733247826904 0.184316152098127 2.0 True False False False False False False 0 insufficient_or_context_specific +PRR14 -0.0940966350216415 0.781241027767254 0.932437573046198 0.228780727563434 0.515863383957061 0.799542807959285 0.428509063407721 0.344462400916286 0.0356654824689173 3.0 -0.136834691425026 0.677860015872792 0.0545166726799729 0.847457026379428 -0.0823180187450533 0.783370270625946 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EFCAB2 -0.05036819747194 0.781354720106694 0.932467857452975 0.0732229563847593 0.663914702159244 0.874384483010807 False False False False False False False 0 insufficient_or_context_specific +SRP72 -0.0606044804948618 0.781604783611366 0.932510028396219 0.0167789193745436 0.938526723087347 0.983422503211216 0.2642692320668 1.0 -0.473476337520145 0.0632681150299086 0.11125627306616 0.626849210640723 -0.362220064453986 0.122350390517193 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ENAH -0.0778211827713191 0.781918941788969 0.932719487900568 0.231984678652323 0.378128339143624 0.715375612319217 0.5114112917484579 0.0005520824848063151 2.0 1.54668548797204 0.0035293552289981 -1.40800093891825 0.0035117850218887 0.138684549053796 0.780833643563065 reversed False False False False False False False 0 insufficient_or_context_specific +CCDC91 -0.0430919830359465 0.782311611089298 0.932984765428793 0.0033754591155609 0.982480602192495 0.99451887511202 -0.275914308899751 0.279291369053755 -0.181806003161106 0.411159796842026 -0.457720312060856 0.0626274568741048 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LACTB 0.0681370928677413 0.782386724706038 0.932984765428793 0.124403070704091 0.613238620391882 0.850400399282578 0.709705054618238 0.8124677299881491 2.0 -0.237510104106521 0.516877879577924 0.254753319922871 0.388726195136093 0.0172432158163499 0.963592920213227 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TTC32 0.0946113484660319 0.782406432383646 0.932984765428793 0.234823680790205 0.493455261139788 0.786363265568912 -0.316005203506062 0.538021773301436 0.287241268570466 0.466063241952471 -0.0287639349355957 0.95468228973023 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SIRPA -0.102999623777558 0.782891077356269 0.933351851256492 -0.105977834586592 0.776771522858716 0.922929747731524 0.542643223754713 0.183901878864476 -0.499104835817005 0.152631182260035 0.0435383879377072 0.922845826959116 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF510 0.0764267132532726 0.78327633829168 0.933597104428259 0.285320006502377 0.304539391543105 0.661341495477036 True False False False False False False 0 insufficient_or_context_specific +CASK 0.0553207970892818 0.783459013605853 0.933597104428259 -0.0015147106454379 0.993968008995719 0.998542598236847 -0.293828074959871 0.416984035146931 0.262049571504217 0.368004800585351 -0.0317785034556542 0.931785027561273 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL133346.1 -0.15016563758196 0.783636877578139 0.933597104428259 -0.0328760116314039 0.95181021277343 0.986917609553614 False False False False False False False 0 insufficient_or_context_specific +DHX29 0.0362467304212227 0.78375369514 0.933597104428259 0.0992756799439102 0.447492451697869 0.761913450254169 -0.130387514215643 0.740261315262556 -0.0254724857913561 0.93926748787036 -0.155860000006999 0.639987010244466 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC105760.2 0.0918782773009338 0.783808133944654 0.933597104428259 0.372410276178924 0.2734112158123 0.6371317291179 True False False False False False False 0 insufficient_or_context_specific +TCEAL4 0.0808304029563307 0.784014786647549 0.933597104428259 -0.0008920127636115 0.997730003496232 0.998960016776977 False False False False False False False 0 insufficient_or_context_specific +DLGAP1 0.10727864392089 0.784184353676384 0.933597104428259 0.149057211001297 0.705526301964276 0.892859178331413 True False False False False False False 0 insufficient_or_context_specific +ISOC2 -0.0957290865284367 0.784401262067163 0.933597104428259 -0.0013475186777334 0.997053742968604 0.998795540446485 False False False False False False False 0 insufficient_or_context_specific +C5ORF24 -0.0833377843641965 0.784449646284727 0.933597104428259 0.30410437045705 0.299170325729395 0.657228526643977 0.461068271641554 0.0176645843847045 2.0 False False False False False False False 0 insufficient_or_context_specific +TXNL1 -0.0629791522829467 0.784458312651281 0.933597104428259 -0.0593125799912987 0.796736923437826 0.928937498275217 0.236871922463485 0.519674707423909 2.0 0.0176968201519507 0.960208911591953 0.284769848106349 0.233741203762072 0.3024666682583 0.232114322996526 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCEA2 -0.0853491625759246 0.784524131989795 0.933597104428259 0.0527906703407126 0.86717595105605 0.958405076023215 0.771070534785246 0.135937473769856 -1.64337618268328 0.0048120015520142 -0.87230564789803 0.118868168104475 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LCOR -0.0600517934870443 0.784742149849392 0.933597104428259 0.133599834074642 0.53577781088587 0.811467813417446 0.0613866893729669 0.829010029691934 -0.422310620261738 0.0491833777559882 -0.360923930888771 0.100359027519763 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACCS -0.0789986266097793 0.784798916091829 0.933597104428259 -0.329766375181962 0.233706777618617 0.602697571243329 0.602080789169892 0.156407450372314 -0.802536261190186 0.0373805661348381 -0.200455472020293 0.644726685772793 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CRAMP1 -0.0610606173226522 0.78480987446358 0.933597104428259 0.0551095690315832 0.807977443178112 0.932788199072101 False False False False False False False 0 insufficient_or_context_specific +TTC21A 0.0831404596990116 0.784821756970255 0.933597104428259 0.178202768882919 0.559366249747619 0.821846488287693 True False False False False False False 0 insufficient_or_context_specific +JTB -0.0855948036146234 0.784865305825462 0.933597104428259 -0.0231118816567504 0.94352999122177 0.984366565940656 0.0163318315420658 1.0 -0.275900250708202 0.323220372540363 0.216275317637897 0.365735717847491 -0.0596249330703046 0.835549729418328 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF91 -0.0433794440650702 0.785019994100072 0.933648966954012 0.0416960517987815 0.794304139230261 0.928063228447907 False False False False False False False 0 insufficient_or_context_specific +MLH1 -0.0651578689762313 0.785085767059834 0.933648966954012 -0.344626332499283 0.142397477974914 0.528011532230573 0.5809065162166861 1.0 -0.157812285663416 0.680500614587848 -0.474709525002322 0.114486552317166 -0.632521810665738 0.0607564440809502 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPM1L -0.152748944441832 0.785246236647534 0.933698979226433 -0.292678081081642 0.600768506913457 0.84360251650955 -1.10453391717173 0.0155829735326893 1.16089892818585 0.0074282911606038 0.0563650110141247 0.894453709675096 reversed False False False False False False False 0 insufficient_or_context_specific +MASP1 -0.0973650516012804 0.785304691753242 0.933698979226433 0.0891895303613594 0.804221622132268 0.931640540539005 0.0330972678753498 0.936257534403958 0.345460751214755 0.221011140130048 0.378558019090104 0.199103607676932 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCT6A -0.0807104486912645 0.785770936516808 0.934140968046601 -0.0267449905970452 0.928377703754957 0.979201977646837 0.302359095367271 0.382879533187396 0.12756941986724 0.67111007680095 0.42992851523451 0.167724063999369 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AMOTL2 -0.106708579855981 0.785853388727971 0.934140968046601 -0.316785805429464 0.407656300425992 0.734313916303325 0.165257581429153 1.0 0.0322180748178841 0.935285427653295 0.142556485524262 0.601370426415146 0.174774560342146 0.545429013479587 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF563 0.0797170088190361 0.786226949636489 0.934374621146111 0.0977750712203425 0.740777978493969 0.908406208990048 True False False False False False False 0 insufficient_or_context_specific +PIGG -0.047059109784739 0.786331385397357 0.934393558472178 -0.213913468100229 0.217017357990834 0.588712555412956 -0.040207389539542 0.919987746794769 -0.0526634115961285 0.858376700664467 -0.0928708011356705 0.769621202374991 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAPK10 0.0763815532569082 0.78676863283057 0.934600200366869 -0.0131581937369268 0.963056213114875 0.989935386867005 False False False False False False False 0 insufficient_or_context_specific +TARID 0.104602097633418 0.78679905015593 0.934600200366869 0.243331356687611 0.525507718128274 0.804676662787375 True False False False False False False 0 insufficient_or_context_specific +KAT6B -0.0528293286191154 0.786856771564708 0.934600200366869 -0.110671034765699 0.570702515697988 0.826426712486539 0.689329272242981 0.0310071580014565 -0.242921244882196 0.360761765124417 0.446408027360785 0.122117060583313 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C2ORF76 0.0928077622853382 0.786872407165783 0.934600200366869 0.193125747205729 0.575567924851011 0.829928048970172 True False False False False False False 0 insufficient_or_context_specific +SFI1 -0.0670092601458289 0.78694788608273 0.934600200366869 -0.0431541114431846 0.861948131529568 0.957822965712685 0.323699110058507 1.0 -0.246106948679689 0.44416359724533 -0.256726231579458 0.343980349454382 -0.502833180259147 0.0866519301190438 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP28 0.0779093659627441 0.787157589710999 0.934744104394188 0.0359253325599417 0.90166424620638 0.968539130272354 -0.0029142750381241 0.996779540451992 -0.479364419440159 0.263918330032816 -0.482278694478283 0.314977321391703 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TSPOAP1 0.0981632936724243 0.787459596812498 0.934842185900527 -0.107903677101507 0.766146153163577 0.919222600731922 False False False False False False False 0 insufficient_or_context_specific +TGIF1 -0.0887420318529789 0.788027547856949 0.935200252697671 -0.267742090947277 0.406532401836307 0.733961461951707 0.316394773358046 1.0 0.560041976408353 0.159745690897976 -0.211931863211025 0.518008289119145 0.348110113197328 0.349634261473776 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHRM3 0.128867861108381 0.788161758714139 0.935200252697671 0.0506636487344491 0.915728833787659 0.975016642510095 True False False False False False False 0 insufficient_or_context_specific +TUBG2 0.0560477878457036 0.788520215937048 0.935454456869449 0.0176330283270978 0.932634314081901 0.981045440677165 -0.311930245508783 0.764545665832228 -0.226333650413494 0.778847583482528 -0.538263895922277 0.535820115516652 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ME2 -0.0709637939588789 0.788593689712033 0.935454456869449 0.100623827374194 0.70726685197087 0.893280888368658 0.477837550244879 0.326047081407242 -0.237437301763241 0.537042545447411 0.240400248481638 0.610270567558596 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEC22C -0.068464845841838 0.788641799639607 0.935454456869449 0.0063026809226232 0.980456759199614 0.994014064108846 0.464598557908295 1.0 0.0051751323099806 0.995740876664603 0.335483008860864 0.51823905277349 0.340658141170845 0.588955351259302 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM39 -0.038807118062481 0.788889402129174 0.935643036135679 -0.149253052608957 0.288633257546274 0.648310091921223 0.265160976755279 1.0 -0.129465409328016 0.725605625213048 -0.688817684116112 0.0288080246193077 -0.818283093444128 0.0189497431817864 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATAD2B 0.0352842401716801 0.789045871364405 0.935723498805503 0.128657282866034 0.326578814574518 0.675949642085426 0.390857706125829 1.0 -0.16581237148921 0.621250010750036 -0.32639482763337 0.219829160185 -0.49220719912258 0.0923888670855275 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TDRD9 0.10575828678449 0.789298883846023 0.935813320117497 -0.132249765456598 0.731160757654455 0.904431845923655 False False False False False False False 0 insufficient_or_context_specific +ANO5 0.14803664326296 0.789633607587094 0.935918080678688 -0.0311301238401973 0.954437998344472 0.987410276805219 False False False False False False False 0 insufficient_or_context_specific +DAPK2 0.0839082783115671 0.789779083309901 0.935918080678688 0.122365969115971 0.697138994381618 0.888803059281445 -0.504434784786254 0.129131577613551 0.212413539622914 0.470426286240017 -0.29202124516334 0.339529909884576 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SWT1 0.0407313893614509 0.790140050004742 0.935918080678688 0.207197884505659 0.181825545189786 0.564455779510072 -0.310992134862229 0.538058611485946 0.688427794756167 0.0781598317302911 0.377435659893939 0.364784106014938 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AAGAB -0.0578594123984749 0.790302733157698 0.935918080678688 0.162804567780612 0.460759222429002 0.768757248799843 -0.103069284732284 0.778024838669967 -0.213045718106131 0.434469591226065 -0.316115002838415 0.271924588094661 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SDC3 -0.0671057826524513 0.790386486629821 0.935918080678688 -0.213199278144386 0.376536314678333 0.714064764642842 1.42193287210156 1.0 0.21735797014501 0.510396029069362 -0.185163786444688 0.502205444595075 0.0321941837003219 0.923755646681849 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RTL8C -0.0808104968593179 0.790463943785836 0.935918080678688 -0.0194147443787543 0.950056812806145 0.986917609553614 False False False False False False False 0 insufficient_or_context_specific +NR4A1 0.20508725356597 0.790598525433049 0.935918080678688 -0.446806915363586 0.56942467230579 0.825719070957423 0.320986508566685 2.12967516118772 0.208403158841644 3.0 -0.263508972447197 0.660335272823634 -0.224764636775944 0.638554742460503 -0.488273609223141 0.329709493369101 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ORC4 -0.0634779692954388 0.790813736706421 0.935918080678688 0.0395031192300269 0.869760501973021 0.958502690861149 0.301695360467189 1.0 -0.0722382664997714 0.848480000850431 -0.38973879772828 0.146641609710347 -0.461977064228052 0.107191296421285 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TOM1L1 0.0579403822105038 0.790846480320001 0.935918080678688 -0.244279713524785 0.280813248701856 0.642821222582925 -0.638844846319198 0.0978607520875192 0.520158185124809 0.114114958276198 -0.118686661194389 0.754012828326835 reversed False False False False False False False 0 insufficient_or_context_specific +CADM1 -0.101739026803714 0.790947250629631 0.935918080678688 -0.121309485366286 0.752454213785802 0.912996564506704 0.286157777869443 1.0 -0.335458547366981 0.34475600395944 0.0504159685112169 0.884559793424643 -0.285042578855764 0.375262172304251 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SUFU -0.0508165297631851 0.791185693673412 0.935918080678688 -0.0824985637177059 0.665176397351387 0.875081569913425 0.14361056416163 0.803303480706222 -0.281474846288858 0.476895872381749 -0.137864282127228 0.782666412248043 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF274 0.0577457157572273 0.791199480731479 0.935918080678688 0.0122704656393469 0.954780161418185 0.987410276805219 True False False False False False False 0 insufficient_or_context_specific +AC104827.1 -0.107417307955095 0.791238148081902 0.935918080678688 -0.0878141669478035 0.829087153222482 0.942947704141109 False False False False False False False 0 insufficient_or_context_specific +ARHGAP22 0.10308155918432 0.791259776653527 0.935918080678688 -0.088498233604374 0.825311859830578 0.941303080489494 0.35764730124183 0.660079599353143 -0.915912319172331 0.139207006469213 -0.558265017930502 0.448908336133072 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDGFA -0.153863428823477 0.791457449375271 0.935918080678688 -0.227423406507495 0.694366917170866 0.887432585446834 0.506691300029347 0.879621909730043 0.0276964547816469 3.0 0.344605165962704 0.167392027656981 -0.562903222943486 0.0210151337901221 -0.218298056980782 0.348969288223614 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OLFML1 -0.146723806568614 0.791476547948558 0.935918080678688 0.521179920795971 0.367975525096533 0.708317354196916 0.283846525418295 0.267419018107283 0.104901126302529 0.646241649557706 0.388747651720824 0.103179595445328 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC083837.1 0.169689882564361 0.791551322913346 0.935918080678688 0.397870783200367 0.53875663873868 0.812366836875604 True False False False False False False 0 insufficient_or_context_specific +ZNF420 0.0524960605614532 0.791595110564801 0.935918080678688 -0.0917867814672141 0.651575649245889 0.870123466781337 0.468431706044541 1.0 False False False False False False False 0 insufficient_or_context_specific +SNX4 -0.0349421936255356 0.791692022972283 0.935918080678688 -0.0553321790235034 0.672408447028346 0.877133430257505 0.2683501521343361 1.0 0.335917313185832 0.193010785431213 -0.709418737634401 0.0088713719306115 -0.373501424448568 0.128787731894526 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCK1 -0.118902920687914 0.791791136842954 0.93593045485758 0.09122278632848 0.838305258243469 0.9478289694297 -1.72552061126834 0.0069674076698626 1.51619252665681 0.0106120872235613 -0.209328084611525 0.704157063557181 reversed False False False False False False False 0 insufficient_or_context_specific +GAS6 -0.0778143696291426 0.792093497263165 0.935936945981962 0.019082200848583 0.949134906836226 0.986917609553614 0.928210094277174 1.0 0.212506652779768 0.68125765850255 0.261602512462795 0.521203541666852 0.474109165242562 0.26243986758422 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRMT9B -0.058354280908352 0.792355478893082 0.935936945981962 -0.0427981271140361 0.846608201435562 0.95232147781341 0.5905892691158849 1.0 0.0629140182965955 0.935803608428753 -0.51476003627583 0.30065212543536 -0.451846017979234 0.439665464839222 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FASTKD1 -0.0713127020828471 0.79235760839634 0.935936945981962 0.099869698029054 0.706205132409098 0.892947759038953 -0.124034495760103 0.781728500216986 0.0114670715787674 0.975105641309043 -0.112567424181335 0.770400403556348 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAPRIN1 -0.0434679267000757 0.792392285226343 0.935936945981962 0.103025457621563 0.540158378706697 0.812783927483158 -0.0613199273771379 0.881058416823645 0.0681128129310274 0.821587172464004 0.0067928855538895 0.985491115834134 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTTY14 0.304653853945659 0.792462722392104 0.935936945981962 -0.316665240715978 0.785078263899335 0.925705787798454 False False False False False False False 0 insufficient_or_context_specific +YBEY -0.107087603965082 0.792631184182374 0.935936945981962 -0.0780470741354167 0.849373910616662 0.953127856970211 -0.142621876703979 0.808845427351056 -0.340683179649232 0.404768669609501 -0.483305056353211 0.29520433301656 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01197 0.0884019459823599 0.792918116181312 0.935936945981962 0.232536650682805 0.48401474644733 0.780666906162311 0.407793625694986 0.3858830458314679 2.0 True False False False False False False 0 insufficient_or_context_specific +ZNF839 -0.07202213324358 0.79304664918706 0.935936945981962 0.0410477375925705 0.882566163458163 0.962778177759102 0.558717856011043 0.915958917548575 2.0 False False False False False False False 0 insufficient_or_context_specific +MAP2K1 -0.0540020545114989 0.793362749398822 0.935936945981962 0.0212566189528538 0.918451325347827 0.975930957742715 0.360006349252553 0.663826555909792 2.0 -0.198913638132206 0.450742324667811 0.290005572891152 0.179389307609338 0.0910919347589455 0.715123135841064 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM15 -0.0629452134395911 0.793381388684874 0.935936945981962 0.0173073912387206 0.942859964252327 0.984366565940656 0.334960469524486 0.148757698730074 -0.222407976949382 0.265500486984525 0.112552492575104 0.618212308630429 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF111 0.0385867032633027 0.79338780194313 0.935936945981962 0.050257049301025 0.732204242987365 0.904431845923655 -0.0166631586508759 0.95834264814358 -0.216205225991859 0.321564638936243 -0.232868384642735 0.315877058346259 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DNAAF5 -0.0645029558962781 0.793398928117464 0.935936945981962 -0.177227681460257 0.473890402107497 0.776334571929151 -0.284184162168787 0.542043747850166 -0.318675635249477 0.396003480965322 -0.602859797418264 0.145210480488523 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLR2B -0.0414119370133132 0.793417285791691 0.935936945981962 0.0649857249265748 0.672937075037994 0.877361032137705 0.442411452083965 1.0 0.26312110089471 0.392153800395507 0.181581320192882 0.468164393562029 0.444702421087592 0.110547331968024 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF202 -0.0808682711850154 0.793519353664237 0.935936945981962 -0.120750855971154 0.692738861042804 0.886799724697293 False False False False False False False 0 insufficient_or_context_specific +SNRNP35 -0.061655542552035 0.793661000803238 0.935936945981962 0.123512831266722 0.586653983424663 0.835274227991216 0.511739366217834 1.0 0.129793611081064 0.806704607114428 -0.15717027745781 0.683990435411482 -0.0273766663767456 0.954370601215956 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARID4B 0.0345231011624489 0.793788396004676 0.935936945981962 -0.006799834053037 0.958679986204005 0.988258474354802 0.09876759002347 0.807345181558748 -0.56015108592138 0.0665139814003498 -0.46138349589791 0.142623003189104 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL450998.2 -0.102440001699688 0.793824805028229 0.935936945981962 -0.533473650900378 0.129672755461519 0.514693591038617 False False False False False False False 0 insufficient_or_context_specific +FAM229B 0.123706467323445 0.794084031873617 0.935936945981962 -0.629088053020151 0.175876539232207 0.557953042949168 False False False False False False False 0 insufficient_or_context_specific +MOB2 -0.0589751674336968 0.794118291418869 0.935936945981962 -0.259634631110909 0.233712721510025 0.602697571243329 -0.185328576435305 0.604101754500267 0.353349617766873 0.208121702130878 0.168021041331569 0.590629128328278 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CNOT1 -0.0371545918410988 0.794332462859289 0.935936945981962 -0.10516788262357 0.459083334609734 0.768296389248185 0.156723892841417 0.583344720725326 0.124454887646086 0.587213233244138 0.281178780487503 0.243245670319536 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C9 -0.121597381987323 0.794389589325112 0.935936945981962 -0.265811705352041 0.568268273687113 0.825129552905055 -1.58830710877748 0.0017043108476045 1.74145453294212 0.0013228279501821 0.153147424164639 0.694938629100527 reversed False False False False False False False 0 insufficient_or_context_specific +CCDC134 0.0816938354485803 0.794430657789373 0.935936945981962 -0.0021081093356764 0.994929897918689 0.998795540446485 -0.322754846473984 0.624007615956223 -0.305101248863651 0.562092981692175 -0.627856095337635 0.26552257421949 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MACO1 -0.0452493472670641 0.794438963318813 0.935936945981962 0.0008521590562334 0.996064457704109 0.998795540446485 0.5580222913458249 0.539228794895692 2.0 -0.145307577543981 0.558494662205646 0.0432869501164414 0.845253861943224 -0.10202062742754 0.650942491177544 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VDAC1 0.0677330175690671 0.794515311316386 0.935936945981962 0.113491283257605 0.663171148016637 0.874236606412742 -0.0459546680224073 0.902911268270029 0.479908459012039 0.0674748285531909 0.433953790989632 0.111759929490232 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TDO2 -0.138644883113218 0.794544690929752 0.935936945981962 -0.223994794365923 0.673482158322524 0.877738560778784 -1.34483863492473 0.0385636239429709 2.25775502468893 0.0033471189363927 0.912916389764197 0.116408400608003 reversed False False False False False False False 0 insufficient_or_context_specific +PTPN11 0.0587303360033057 0.794792843452236 0.936124814945192 -0.129471846090802 0.567653024545152 0.824849995454606 0.0403706270980297 1.0 0.253174279228428 0.265599696701717 -0.131406761028391 0.503949822270013 0.121767518200037 0.574442723444002 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LSR 0.0969539936200096 0.79548164498341 0.93672710324948 0.0660993929249062 0.859413995095636 0.956914759994669 -0.134137544029071 0.680500614587848 0.210545120821075 0.407058284108077 0.0764075767920041 0.796335784687827 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMED3 -0.0801679266760031 0.795851141488801 0.93705769508629 0.459410197237551 0.118276051810416 0.49810871759648 -0.0795056126387362 0.873536099921662 0.376147812701815 0.271842931429136 0.296642200063078 0.418974619247488 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TSKU -0.186733942075132 0.796397873745312 0.937254065233556 -0.172474648414617 0.812140989767591 0.934063202799411 0.6155749244463691 0.479236435736141 2.0 -0.0686020470795395 0.930958770751862 0.100548652373458 0.867763479272939 0.0319466052939187 0.961592032678043 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DCUN1D5 -0.06308771597221 0.79661825697597 0.937254065233556 0.0416971544538702 0.86412069158295 0.958391272020028 0.167202308151719 0.547797335630674 -0.475102351456173 0.0489796245256278 -0.307900043304455 0.200262247736983 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APOL3 -0.0742138377464886 0.796648318419397 0.937254065233556 -0.165387904249361 0.566324551009836 0.824113119711934 False False False False False False False 0 insufficient_or_context_specific +SYNJ1 -0.0415387014764813 0.796728095801398 0.937254065233556 -0.0184141002407193 0.908978179666585 0.971465990561519 -0.0314053005919843 0.936257534403958 0.163797878184023 0.529101554546551 0.132392577592039 0.655006807287611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM106A -0.0595817706704875 0.796909411310807 0.937262024585861 -0.0068019724588576 0.977495577825841 0.993500350721674 0.297997964243815 0.350627726614044 -0.0550379058064066 0.849744054751943 0.242960058437409 0.402954108447658 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LDHB -0.0777821884168775 0.797165527453542 0.937262024585861 0.0011581993712838 0.995794930381197 0.998795540446485 -1.17468202000444 0.0205616795162199 0.49532393683377 0.236689187099363 -0.679358083170675 0.118446777037918 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TOX -0.104541933920583 0.797576796344138 0.937262024585861 -0.298760947876956 0.4580136201688 0.767816418187074 False False False False False False False 0 insufficient_or_context_specific +CASC15 0.0997676559825796 0.797652163858066 0.937262024585861 0.195494378548786 0.614658826755071 0.851202504312702 True False False False False False False 0 insufficient_or_context_specific +RABEP2 -0.0768818829928004 0.797692257841959 0.937262024585861 -0.0794289669303929 0.79151079612532 0.927588847807277 -0.484451079813285 0.142940613664619 -0.560594797061858 0.0683357758574533 -1.04504587687514 0.0077946103461364 partial_or_other False False False False False False False 0 insufficient_or_context_specific +P3H4 -0.0801671316066004 0.797792413641311 0.937262024585861 0.159007756439435 0.624886535143005 0.856338486330344 0.3336067616727489 1.0 -0.271405932587006 0.466248262084213 -0.0882307887787423 0.789783847223173 -0.359636721365748 0.271679690540273 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IFFO2 -0.0924027037710325 0.797877238759614 0.937262024585861 -0.12501700623223 0.7294630988456 0.904204533048315 0.161299271948423 0.536816601487777 2.0 0.20293523393873 0.47962369032109 -0.268344552400526 0.25037257366667 -0.0654093184617957 0.81819222997437 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCEAL3 0.0821461850248868 0.797929176737467 0.937262024585861 0.0534598485436491 0.86555877324537 0.958391272020028 0.336175542868419 1.0 True False False False False False False 0 insufficient_or_context_specific +DNASE1 0.065521215710127 0.797977679390254 0.937262024585861 -0.0663508588085291 0.790772260059335 0.92749893235615 False False False False False False False 0 insufficient_or_context_specific +BRPF3 0.0719089674022877 0.798405406752463 0.937620014490837 0.0666629575771946 0.812795701489182 0.934294721428719 0.313882688102242 1.0 -0.280174353821998 0.253452962506105 0.0212103271188784 0.931634464451102 -0.258964026703119 0.249239030029639 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SAMD4A 0.102778305182091 0.798548889022695 0.937620014490837 -0.146036558417388 0.725406232177105 0.903230533056069 0.35831401555271 1.0 False False False False False False False 0 insufficient_or_context_specific +EMD -0.106132218186571 0.798685905732154 0.937676614335603 -0.116992482678987 0.778563472828204 0.922929913000972 -0.233842028999304 0.546443183042633 0.317642457123343 0.293630028905344 0.083800428124039 0.820746829632542 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC007364.1 -0.0834368760266042 0.798882661558602 0.937803328967726 -0.0549996989822137 0.86673241931116 0.958391272020028 False False False False False False False 0 insufficient_or_context_specific +GRSF1 0.0596377763637668 0.799349292430756 0.938240965993236 0.121265577215688 0.604281768160527 0.845706111908648 -0.138062045550944 0.764935555098629 0.291983795780383 0.395919184106118 0.153921750229438 0.693949154361178 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HNF4G 0.114861659808409 0.799497957403962 0.938240965993236 -0.0062776945508331 0.989150012414338 0.996797349534273 False False False False False False False 0 insufficient_or_context_specific +TMEM63B 0.0603821855895277 0.799522065830758 0.938240965993236 -0.0407442303723743 0.865226429075267 0.958391272020028 -0.449633889832735 0.108188127917491 0.0173266866944779 0.951765091987686 -0.432307203138257 0.100556290330782 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPIB -0.071784640747509 0.80006564458317 0.938694084061061 0.17082488794016 0.566372873331104 0.824113119711934 0.180916801301056 0.31598185851331 2.0 -0.122042295676332 0.753444349195425 0.358939350381315 0.222187830134011 0.236897054704983 0.443529638632892 partial_or_other False False False False False False False 0 insufficient_or_context_specific +A2ML1 0.164714919594952 0.800257385611707 0.938694084061061 -0.698425790765489 0.271282046551184 0.635344560550917 False False False False False False False 0 insufficient_or_context_specific +KDELC2 0.0799977318463473 0.800386296879292 0.938703642857403 -0.0125078454589627 0.967756990439262 0.991065707083724 False False False False False False False 0 insufficient_or_context_specific +SH3BGRL2 0.0709802633620485 0.800521120786653 0.938703642857403 0.162787820793998 0.557909694615381 0.821366572837071 -0.810552752633573 0.0759063903224041 1.08863431616703 0.0133748901875806 0.278081563533457 0.490123065276328 reversed True False False False False False False 0 cross_species_direction_conflict +TNFRSF10D -0.0866861367690058 0.800610906181593 0.938703642857403 -0.528643323950166 0.101782739046085 0.479100382901725 False False False False False False False 0 insufficient_or_context_specific +PPP1R3F -0.0741167376078681 0.800763617790999 0.938703642857403 -0.294332723868305 0.310024234688847 0.663404108197172 0.120910084391446 0.30983390121688 2.0 1.40098653762809 0.0296420112408737 -1.04595681521205 0.0354818712239347 0.355029722416035 0.592831727311918 reversed False False False False False False False 0 insufficient_or_context_specific +MTCL1 0.0703676406085486 0.800771642168925 0.938703642857403 -0.155132828514838 0.565862367938789 0.824113119711934 1.91540464741476 0.0733914383402823 -1.33635608762192 0.07756508779826 0.579048559792845 0.638710045383609 reversed False False False False False False False 0 insufficient_or_context_specific +CU633967.1 -0.157797444593655 0.80094942241202 0.938703642857403 -0.114920725551607 0.854958081641242 0.955391934779887 False False False False False False False 0 insufficient_or_context_specific +UGDH-AS1 -0.0609037122275827 0.8009832466852 0.938703642857403 -0.0091333086934504 0.969806175130124 0.991737938845345 False False False False False False False 0 insufficient_or_context_specific +AC008074.1 -0.0685994492951723 0.801473747270349 0.939070005957202 0.0530381569400849 0.847101951142887 0.952541014278606 False False False False False False False 0 insufficient_or_context_specific +STYXL1 -0.0519754724221455 0.80174723525567 0.939184996589102 -0.10466137517356 0.615786887212916 0.851916120639411 False False False False False False False 0 insufficient_or_context_specific +SLFNL1-AS1 0.124377720722337 0.801833170506607 0.939184996589102 0.0822106383929092 0.868065391281292 0.958502690861149 0.43194646108392 1.0 True False False False False False False 0 insufficient_or_context_specific +RAB3IL1 -0.103870561239305 0.801924449207168 0.939184996589102 -0.0786660813222442 0.849721722980192 0.953127856970211 0.281183327065114 0.679889198307056 2.0 0.452591515733096 0.214082877414911 -0.24487465405636 0.428049490012478 0.207716861676736 0.553933620392347 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DPF2 -0.0508319300173415 0.801927708301833 0.939184996589102 -0.158172169955923 0.422445089742494 0.744106649566441 0.129316566316498 0.662459607246125 -0.0289906386063267 0.912466144950524 0.100325927710171 0.704471617504536 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FRG1-DT 0.0993587243667485 0.802246317151298 0.939291254044972 0.0059394626502332 0.988428185502791 0.996718493722613 True False False False False False False 0 insufficient_or_context_specific +PRMT2 0.0480621949938406 0.802384889985855 0.939291254044972 0.142386566498078 0.457535298701897 0.76776776876263 0.446265536006819 1.0 -0.309171797376602 0.41730467354195 -0.144274725794128 0.662147458035728 -0.45344652317073 0.185853928434108 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC114689.3 0.0803749398435516 0.802495395554066 0.939291254044972 -0.41325296834672 0.219995331780635 0.59217704709374 False False False False False False False 0 insufficient_or_context_specific +RIOK2 0.0976179692677795 0.802508561508987 0.939291254044972 0.270187265291742 0.499199739993465 0.79006908332349 -0.298136090688809 0.300927870074976 -0.211277162671998 0.397742410173623 -0.509413253360807 0.0652158915579853 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC008124.1 -0.066854263309496 0.802611412083489 0.939291254044972 0.251618348880287 0.360091317242039 0.702743831320045 False False False False False False False 0 insufficient_or_context_specific +BMT2 0.0524363034874633 0.802641190944662 0.939291254044972 0.125289299396337 0.54890097436999 0.816365047001981 -0.0218248106337795 0.944222686843845 -0.436483097307089 0.0503881637611101 -0.458307907940868 0.0522558384353327 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC02133 -0.142133422908817 0.802905729863988 0.939496696875095 -0.179804350566494 0.750733565000612 0.91169139398165 False False False False False False False 0 insufficient_or_context_specific +SPRTN -0.0914529801956712 0.803257811826897 0.939804518757577 0.0638672901018325 0.864479247291282 0.958391272020028 0.792503824197785 0.0819599170407538 -0.262152253923824 0.459498462808074 0.53035157027396 0.21305755771939 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01362 0.113999569209356 0.803366343263135 0.939827352041238 0.296489298811503 0.518079179114234 0.800840369846825 True False False False False False False 0 insufficient_or_context_specific +OSTC -0.0777874615020264 0.804104712993011 0.940272375595182 -0.0645105008433053 0.837163984561881 0.947553317860671 0.447035739510926 0.274263560228986 -0.0238094772993549 0.952710147826731 0.423226262211571 0.257682679108266 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLCB1 -0.0706506864462326 0.804117277202722 0.940272375595182 -0.194886961598908 0.488186708114369 0.782967532169452 1.45797096247059 1.0 -0.379146974574682 0.313455874466706 -0.0636099230587634 0.861264555817373 -0.442756897633445 0.196378541843254 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNHG8 -0.123967812898675 0.804272906306056 0.940272375595182 0.111224236204311 0.825925428708533 0.941799403424202 False False False False False False False 0 insufficient_or_context_specific +STX10 0.0938128771180956 0.804290982565684 0.940272375595182 0.0636633102653242 0.8656078490016 0.958391272020028 True False False False False False False 0 insufficient_or_context_specific +MRPL42 0.0513886102277748 0.804388017691833 0.940272375595182 0.163542357955867 0.433259030590221 0.751350456611089 True False False False False False False 0 insufficient_or_context_specific +ANKRD23 -0.0530712753778991 0.804388579386238 0.940272375595182 -0.117053561702776 0.587771325318522 0.835274227991216 0.12121389360638 0.807345181558748 -1.29963380633658 0.0054731003837334 -1.1784199127302 0.0140191036869991 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FCN2 -0.211224663635814 0.804463087216152 0.940272375595182 -0.651518996623505 0.430879047700239 0.749583289770822 False False False False False False False 0 insufficient_or_context_specific +ABHD17C 0.0967892946128458 0.804585851160116 0.940272375595182 0.414823927446208 0.32105648873778 0.672472248121257 -0.432963308167847 0.183605282665112 0.734391649357425 0.017996279742832 0.301428341189578 0.300728833655718 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CDYL -0.0369832742407884 0.804651001609986 0.940272375595182 0.155615807159557 0.305132419611494 0.661381253594365 0.408248888899562 1.0 -0.179933460342456 0.561447014082597 -0.195623477391799 0.434407488400147 -0.375556937734255 0.160807111016338 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRC14 -0.083979396426029 0.804929973949542 0.940272375595182 0.270475758514144 0.420048812918164 0.741990190194073 -0.0533557319844748 0.909943775171077 -0.383769260105874 0.225442413043454 -0.437124992090349 0.199551676918234 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NCOR1 -0.0321648549355475 0.804994482063676 0.940272375595182 -0.0211190983449534 0.870350946892009 0.958502690861149 0.577690471557968 1.0 0.159754492626377 0.527334260052473 -0.107186323379538 0.615361401478211 0.0525681692468393 0.831187882684122 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC092691.1 -0.144461590403819 0.805063480915239 0.940272375595182 -0.649689007633831 0.244452212113611 0.610669341516615 False False False False False False False 0 insufficient_or_context_specific +RBP4 0.0696084019675097 0.80508261748252 0.940272375595182 0.229653289599578 0.411599699660227 0.735291083225579 -0.839431939956232 0.213207196779859 1.0063705956371 0.100327024554949 0.166938655680865 0.809063952550727 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRIP11 -0.0287932865900146 0.805256270872563 0.940371165564929 0.0104636196509485 0.928854445315038 0.979458588812811 -0.149249577947939 0.560637623074215 -0.171197029397714 0.410005085856249 -0.320446607345653 0.14776896621692 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFAND6 0.0367580296083745 0.806022573340523 0.940928558490842 0.0875613508696547 0.558866776050064 0.821668752065948 -0.18602977934211 0.418941545140387 0.350833164684087 0.0771746683802381 0.164803385341978 0.419977012673289 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM13C -0.114169139982578 0.806115437556744 0.940928558490842 -0.020755994409799 0.964531806431521 0.990230145109296 0.6196677643217149 1.0 1.60198767846394 0.0155546247171107 -0.802068392869658 0.0736734941147535 0.799919285594278 0.194425417463289 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF771 -0.0900385308054895 0.806148404304246 0.940928558490842 -0.289045085689044 0.414808522186303 0.736925521999492 False False False False False False False 0 insufficient_or_context_specific +SPESP1 -0.0615740075760207 0.806179175990543 0.940928558490842 -0.26516769119394 0.282562683492415 0.643784379005808 False False False False False False False 0 insufficient_or_context_specific +AL590079.1 0.100583697537419 0.806559552983096 0.940976663404657 0.0314958269449278 0.939174005375717 0.983643567603279 True False False False False False False 0 insufficient_or_context_specific +EPRS 0.0593733896579225 0.806588209533343 0.940976663404657 0.313075709424861 0.197389093579353 0.572466025511161 -0.254042060075555 0.327369814686324 0.225687260940656 0.306323355825859 -0.0283547991348994 0.918258746367039 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM181 -0.0471436855639447 0.806666014441708 0.940976663404657 0.133535429423044 0.484285514991069 0.780743085551337 False False False False False False False 0 insufficient_or_context_specific +TRIM24 -0.0582299334288947 0.807018134006286 0.941192347173745 0.237109124352021 0.29386433278873 0.652324662738756 0.481925865086922 0.139705138049258 -0.544267828017093 0.0619234127648967 -0.0623419629301707 0.858688081188421 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIAH2 -0.0833425419541548 0.807029202402341 0.941192347173745 -0.200649007809619 0.558535494407911 0.821540505706147 0.0122177211237287 1.0 0.169036885112684 0.736918727764877 -0.534279241123831 0.161875009749034 -0.365242356011147 0.374453438315737 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF800 0.0381092508865903 0.80720186682084 0.941289740434551 0.0200868841688423 0.896943532880905 0.967531580672392 True False False False False False False 0 insufficient_or_context_specific +SYAP1 0.0747538521808655 0.80738136996584 0.941307252869151 -0.281370097093541 0.349008338734755 0.694288655897113 0.380390745530157 1.0 -0.234637337642786 0.405949448831043 0.441787280158674 0.0676686031746896 0.207149942515888 0.406626709410067 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HCG27 -0.0944192808407322 0.807740354386759 0.941501729036807 -0.344999823313882 0.369330792314412 0.709345639075664 False False False False False False False 0 insufficient_or_context_specific +OAT 0.0721547158839704 0.808348278994149 0.941508256818038 -0.0621027130439762 0.835048473621595 0.946376318644998 0.267071002120441 1.0 -2.11327253998803 0.0006690048699659 2.53808374558838 0.0005042318032958 0.424811205600343 0.291515003746605 reversed False False False False False False False 0 insufficient_or_context_specific +LARS2 0.0431027082676887 0.808416520902186 0.941508256818038 0.353580625557249 0.037730589966196 0.379484931484566 0.652656688296544 1.0 True False False False False False False 0 insufficient_or_context_specific +ITPR2 0.0457556899239513 0.808555097750918 0.941508256818038 -0.0193629799477902 0.91954647625794 0.976030129318521 0.2923736649053449 0.379637234804334 0.347465903758592 3.0 -0.375841641338812 0.176969671074957 0.0103345629038044 0.971447894886009 -0.365507078435007 0.157681135576469 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LSM8 0.0633607337133092 0.80874638748886 0.941508256818038 0.344807767742508 0.168421814386021 0.547956075931201 -0.0911999626162932 0.846663403416856 -0.103429822119293 0.767059560119834 -0.194629784735586 0.595139012396859 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DSN1 -0.0934477285518255 0.808856110455159 0.941508256818038 0.0488660933756489 0.898925959608186 0.967837995533705 1.70321936212863 0.0503912588889314 -2.34425286824463 0.0069628006375834 -0.641033506116006 0.544931979203416 reversed False False False False False False False 0 insufficient_or_context_specific +GTPBP1 0.0656632968117051 0.808860480732876 0.941508256818038 -0.25902064871419 0.337215634565641 0.685057785656405 0.258569417832686 1.0 0.0244643558276904 0.948814985256369 0.129947420093595 0.603087584877972 0.154411775921285 0.57585981979015 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BMP6 0.154602744749531 0.808905228035274 0.941508256818038 -0.457308556720209 0.452699303624122 0.76491545430188 -0.649259517295024 0.185729142449436 0.162490153751119 0.717774003109478 -0.486769363543905 0.278709886794909 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VPS53 0.0389699439403264 0.809180626710006 0.941564817022646 -0.151611458705146 0.338503105851501 0.686631276000029 0.0195378670467574 0.956348420655611 -0.450823814009931 0.072204504253986 -0.431285946963173 0.100181556652157 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDHR2 -0.178168701778777 0.809765652904043 0.941564817022646 -0.508122869914405 0.47275073178313 0.775593712997022 False False False False False False False 0 insufficient_or_context_specific +CHRM2 -0.14391548383603 0.809859795428397 0.941564817022646 -0.577655401620362 0.327738362961833 0.676889991422347 False False False False False False False 0 insufficient_or_context_specific +RXFP1 -0.144061071069042 0.809985567706073 0.941564817022646 -0.92177220377787 0.124893399100268 0.50716327219255 False False False False False False False 0 insufficient_or_context_specific +RASSF8-AS1 -0.0629337135826783 0.810038630385151 0.941564817022646 0.0371307421269502 0.885363245079186 0.963081098449005 False False False False False False False 0 insufficient_or_context_specific +SERHL2 -0.0722546807525198 0.810191503635462 0.941564817022646 0.016264789024301 0.957621256851456 0.987656798648419 0.393445620053518 1.0 False False False False False False False 0 insufficient_or_context_specific +CAMKMT 0.0387211357219613 0.810311582952772 0.941564817022646 0.204251449628216 0.182368534132413 0.564647209199417 True False False False False False False 0 insufficient_or_context_specific +SLC41A1 -0.0808680191744892 0.810365771801726 0.941564817022646 -0.106731808847238 0.749786993549755 0.911170704177982 0.560111279263237 1.0 0.544157205530323 0.102046402189005 -0.0826238518835585 0.779636844296658 0.461533353646764 0.137106435334608 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NDUFAF5 0.0558831416184742 0.810416318088269 0.941564817022646 0.108294813867755 0.641124333682567 0.864713172563113 -0.10812748045428 0.822913995182288 -0.268994909534226 0.42411723260072 -0.377122389988506 0.308861810252204 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DUBR -0.073337296172467 0.810529535609598 0.941564817022646 0.344754736569092 0.245765448161002 0.611033451076589 0.611948804795908 1.0 False False False False False False False 0 insufficient_or_context_specific +GNL3L -0.0722910804198232 0.810532111309388 0.941564817022646 -0.0179453065374161 0.95376300223815 0.987292667741163 0.0095553064333167 0.977456978032175 -0.343317245573504 0.131129984935151 -0.333761939140187 0.172172094690146 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SQLE -0.10295466941445 0.810685078165642 0.941607596839697 -0.272583228536942 0.510906814839744 0.796519013040946 0.380999710683346 0.658118945492531 0.252910925632864 0.695406645460819 0.63391063631621 0.369225824553017 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM45 -0.0614918401453694 0.811035131198795 0.941806963835996 0.222782658107245 0.424916388419913 0.745882731558725 0.2594298499288 1.0 -0.13182344319934 0.692468360812531 0.052725511183471 0.852624475901395 -0.0790979320158693 0.794949587592665 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLF15 -0.127461670562898 0.811162869448086 0.94185170742691 -0.635629602489127 0.214641324744622 0.587852789707652 0.216574601522282 0.06254344363934901 2.0 -1.05754660117622 0.0053199998934969 1.00432375245372 0.0059369583426228 -0.0532228487225014 0.879785146623525 reversed False False False False False False False 0 insufficient_or_context_specific +FGF12 0.130042290843498 0.812067806861327 0.942591458315951 0.741184086140818 0.198248290500969 0.573453548249106 -0.486590945728463 0.280607069088435 0.786410800519009 0.0431018401756332 0.299819854790546 0.448423373695728 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MARCH1 0.0757379696072944 0.812912439345913 0.943260746742955 0.143216183865246 0.658501045054025 0.871710320505013 True False False False False False False 0 insufficient_or_context_specific +SPTY2D1OS 0.0644589511493419 0.813218809270763 0.943370464922279 0.118208306400401 0.665244344294517 0.875081569913425 True False False False False False False 0 insufficient_or_context_specific +ANKS1B 0.0915208180751207 0.813275049414907 0.943370464922279 -0.250937707519889 0.502638517280841 0.79229878349175 0.128762383566815 0.553410607012277 0.251555751950941 3.0 False False False False False False False 0 insufficient_or_context_specific +RNFT1 -0.0804268350776289 0.813481475943554 0.943408262176069 0.0680802615038996 0.840980805850705 0.949430640309212 0.0189188105192791 1.0 0.415918149634806 0.213207196779859 -0.356070707288008 0.202495436203569 0.0598474423467979 0.868675330119654 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC069368.1 -0.113612518448106 0.813615098976358 0.943408262176069 -0.0844806287973233 0.862265908246404 0.957822965712685 False False False False False False False 0 insufficient_or_context_specific +ZFX -0.0445641843425785 0.813667071791229 0.943408262176069 0.155314062481416 0.41053812121625 0.735152897523944 0.0525295939226394 0.94066210859735 -0.0308363607149664 0.952179584858255 0.021693233207673 0.971821319506505 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MFSD4B 0.0640145303197602 0.813754408376346 0.943408262176069 -0.229118493161724 0.386699013568506 0.720477739899883 0.69388428606038 1.0 False False False False False False False 0 insufficient_or_context_specific +GBP3 -0.0915339449318222 0.814285825649219 0.943863105022369 -0.0824178235375141 0.832709767373292 0.944841453404322 0.0102607608302858 0.980628573338479 -0.377343351418189 0.181346342106623 -0.367082590587903 0.223301394602426 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLB -0.0596213174238158 0.814435326302064 0.943863105022369 -0.176874122803642 0.491231586545641 0.785509848901139 -0.0545628900957623 0.887010998875188 -0.185243336319634 0.481585545967186 -0.239806226415396 0.397039491968836 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STK19 -0.0778599976784136 0.814501788446676 0.943863105022369 -0.0905467579385661 0.785131805952694 0.925705787798454 0.475859577720057 1.0 0.0852268266317241 0.804826425997151 -0.592854800485807 0.0292723709423685 -0.507627973854083 0.0704794987806679 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDC14B -0.0743002806949813 0.814504333193674 0.943863105022369 -0.197961430623527 0.531621870155018 0.808721353725286 0.502768828051539 1.0 -0.426441110543406 0.297642086230331 0.119446380042223 0.744134314652532 -0.306994730501182 0.409553044197756 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANK2 -0.0916546722142362 0.814684876402555 0.943968714339132 0.164241019873047 0.665451832240141 0.875081569913425 1.08348385602859 0.736840228189484 2.0 -0.649261940330564 0.435827243641088 -0.512430993825275 0.484437093827353 -1.16169293415584 0.141317775711644 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UGT2B15 0.137329070426375 0.815072365686805 0.94431406089337 0.333309128008798 0.572550576746939 0.827730374888659 True False False False False False False 0 insufficient_or_context_specific +FYB1 0.113116019721065 0.815384023620738 0.944467857530197 0.0009004956547702 0.998595167803786 0.999257679999277 True False False False False False False 0 insufficient_or_context_specific +MEAF6 0.0427592955064926 0.815726975065538 0.944664919210897 0.0279088370139715 0.879117843296318 0.961737248940268 -0.0540873109831121 0.876566872609043 -0.329429467895067 0.173165979937461 -0.383516778878179 0.142531679231238 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SDHAF3 -0.0821540251345301 0.815826409007135 0.944664919210897 -0.173444806856699 0.624086562945111 0.85594302057622 -0.101677760511105 0.876433216394697 -0.0321071017609002 0.948648230234386 -0.133784862272005 0.802779075042784 partial_or_other False False False False False False False 0 insufficient_or_context_specific +YIPF3 -0.0796146900580636 0.815912047573799 0.944664919210897 0.0353981964209232 0.916029482660955 0.975207071931587 -0.0569855033316265 0.872628917234512 0.264014160925031 0.286737720129249 0.207028657593405 0.430291358200699 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TP53BP2 -0.0621819378786006 0.816238540855844 0.944697076175537 0.0135989874045049 0.959225430926106 0.988456348454369 False False False False False False False 0 insufficient_or_context_specific +RPAP1 -0.0571738784278323 0.816296198553672 0.944697076175537 -0.141978634328131 0.565486209832756 0.823968224969823 -0.0731954149007879 0.87728135326858 -0.340866619092807 0.293485298780139 -0.414062033993595 0.240638817593483 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPF1 -0.0732785778163121 0.816417258867334 0.944697076175537 -0.382629923837375 0.192382430998578 0.570885363891703 -0.241485300252836 0.403301380914286 -0.0629920339731171 0.812458160629465 -0.304477334225953 0.237098955351032 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP38 0.0576645586422268 0.816431567904781 0.944697076175537 -0.17190672086934 0.464473380544253 0.77000826170754 -0.0019911043189034 0.99684425836205 0.304615978716065 0.34342356809709 0.302624874397161 0.402954108447658 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RFX3 0.0440707727236232 0.816440234999313 0.944697076175537 0.0655578791926987 0.728776235683581 0.904012808833088 -0.701954379819751 0.122682797342233 -0.341829270066502 0.400360954438531 -1.04378364988625 0.0279405435141411 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ASCC1 0.0361123240291659 0.816478398428279 0.944697076175537 -0.0654196928350184 0.664680110909309 0.874805860256854 0.314845641782189 1.0 -0.0967019018725306 0.826861264369012 0.286825624727208 0.327229620913797 0.190123722854677 0.575270158041201 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBRG4 -0.078812146583301 0.816583794607755 0.944697076175537 -0.026050545836972 0.941455016901552 0.984146739450157 0.0233957964663308 1.0 0.275511027546084 0.328535644461382 -0.497782230318399 0.0515795084370423 -0.222271202772315 0.393406439151975 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GOLGB1 -0.0460616618642258 0.816795800763284 0.944697076175537 -0.140208480301742 0.471575740329344 0.774962086083438 -0.0801369793652148 0.777243271577453 -0.165508087439816 0.434170859625625 -0.245645066805031 0.268691019398836 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM76B 0.0715259933117446 0.816889197765364 0.944697076175537 -0.117889114125746 0.701914372577461 0.891472626689863 0.7485668000645072 0.46562321215412 2.0 0.17356093266671 0.554902077918115 -0.686715123314796 0.0136531712302267 -0.513154190648086 0.0562269353681508 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF721 -0.0412261040421621 0.816917658014683 0.944697076175537 -0.0799889278327703 0.650408972969798 0.869901306439436 False False False False False False False 0 insufficient_or_context_specific +USP12 -0.0528305497413293 0.817107220762908 0.944805392269716 0.228316499488384 0.289791578241323 0.649071866901508 0.270981694213232 1.0 0.0936007475129055 0.812390567902429 -0.563819955870422 0.057094402761589 -0.470219208357516 0.126859312546668 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BHLHE40-AS1 0.119254381748745 0.817357695192129 0.944991518379161 0.538472373423156 0.308643200699335 0.662330926800867 2.09874082515582 1.0 True False False False False False False 0 insufficient_or_context_specific +RPLP2 0.0741033279334261 0.817447330167156 0.944991668882605 0.143894733030733 0.653438418906477 0.870639750062571 0.5444309916801551 0.337877606146529 2.0 True False False False False False False 0 insufficient_or_context_specific +SYT9 0.12485636623189 0.817605679128933 0.945071245921094 -0.26606982833964 0.613473929536301 0.850400399282578 -0.418042405544258 0.495330805341603 -0.362799227205891 0.474072849593488 -0.78084163275015 0.158725136733993 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TUB 0.121122637253553 0.81801334016356 0.945438954071906 -0.662069718171441 0.17150534842753 0.552564378607829 False False False False False False False 0 insufficient_or_context_specific +COX4I1 0.0732944626408687 0.8184647033139 0.945667865279361 0.492334514306296 0.123012697048059 0.504414033284339 -0.305149312971505 0.559520649104807 0.624452179216296 0.143809070589513 0.319302866244791 0.478153895096616 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRAS 0.0792695846963191 0.818572488846177 0.945667865279361 -0.0795401400870403 0.817680515341161 0.936646509815772 0.776281352762758 1.11342203479658 2.0 -0.755160801801412 0.10220307992849 0.199786377786713 0.62916535639451 -0.5553744240147 0.187778767803111 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SUCLA2 0.04713966423957 0.818648083228711 0.945667865279361 -0.0304886336882559 0.883615146066843 0.962965391429988 -0.236491475231356 0.525313895293185 0.656654477128124 0.0428568855528751 0.420163001896768 0.188034141309801 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFAT5 0.0338083230890686 0.818659243100337 0.945667865279361 0.174336041675234 0.207994650619966 0.580700057930969 -0.149673767226424 0.655914000308081 -0.468581199841578 0.0870355562679522 -0.618254967068003 0.0398810979916504 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RAPH1 -0.0494063199402164 0.818778112189402 0.945701707526059 -0.159695190769027 0.463020447373874 0.769320698854699 0.248366333032888 1.0 0.235799422941932 0.573151019820247 -0.363019943514951 0.286737720129249 -0.127220520573019 0.743317824093412 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LARP7 -0.0396828145155314 0.818967837957836 0.945763633736826 0.0414387838757458 0.80589742917156 0.932788199072101 0.498371927414826 0.205359529430383 -0.520760428136407 0.113333664991401 -0.0223885007215811 0.959462082466391 partial_or_other False False False False False False False 0 insufficient_or_context_specific +METTL16 0.031871130626529 0.819010883051317 0.945763633736826 0.036549337911385 0.792674593908766 0.927620871373898 0.00290517369014837 1.0 -0.0345157928405209 0.932564035076781 -0.476856424596569 0.0855848027772051 -0.51137221743709 0.0898530637373285 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FBXO3 0.0396631147918649 0.819153785618202 0.945825204347876 0.145704466934684 0.406814024942356 0.733961461951707 -0.115015776545733 0.713504439354663 0.06522848182952 0.803088061364435 -0.0497872947162134 0.865149330177781 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DDI2 0.0320226144426952 0.819293769911342 0.945855410452891 -0.0458957112985816 0.745100455460143 0.909500945159707 0.260710433750148 0.524613024532137 2.0 False False False False False False False 0 insufficient_or_context_specific +RABL2B 0.0559376445355091 0.819359119530417 0.945855410452891 -0.0465485039832082 0.859889082491562 0.956914759994669 False False False False False False False 0 insufficient_or_context_specific +CD46 -0.0322924823979575 0.819599679910147 0.946029511818221 -0.0542312052013368 0.699303359192314 0.889654761580003 0.193494418542858 0.756259296908965 -0.38179217813067 0.397073248581573 -0.188297759587812 0.730932440356379 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF317 -0.0647082709000643 0.82014987060286 0.946029511818221 -0.25521714274465 0.359485791239782 0.702743831320045 False False False False False False False 0 insufficient_or_context_specific +RPS10-NUDT3 -0.100719896020746 0.820165845287285 0.946029511818221 0.0098066298741198 0.985409419681183 0.995307821007743 False False False False False False False 0 insufficient_or_context_specific +DEXI 0.0604918753564938 0.820201302930892 0.946029511818221 -0.0830890808027773 0.749694512966331 0.911163194186545 -0.219672943761315 0.336478835515721 0.0549147116758678 0.794037834214435 -0.164758232085447 0.428232454788778 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NAA35 -0.0388559725730834 0.820307725641474 0.946029511818221 0.213595448584223 0.210404930727877 0.582800422305635 0.0185222105687728 0.97100168852273 0.13184414360549 0.702477185538695 0.150366354174263 0.704471617504536 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZSWIM4 0.076782028106832 0.820476576271922 0.946029511818221 -0.1192140468831 0.728575355816137 0.904012808833088 0.387963660296659 0.6521783617239699 2.0 -0.137382855101114 0.761065473339981 -0.323795080363232 0.335095587625726 -0.461177935464346 0.201833682859162 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM14-RBM4 -0.0430141535344699 0.820531845704712 0.946029511818221 -0.234171641430202 0.234015820185193 0.603018788225434 False False False False False False False 0 insufficient_or_context_specific +SRA1 -0.0755145119575584 0.820646879070731 0.946029511818221 -0.162479462477733 0.6186185987199 0.853546133343446 0.26849069409369 1.0 -0.731271961550651 0.0083248115153425 0.545610953398845 0.0242464293547026 -0.185661008151806 0.416629745247091 reversed False False False False False False False 0 insufficient_or_context_specific +RUBCN -0.050149677600116 0.820665750098434 0.946029511818221 -0.0276854940563506 0.900737894291605 0.968069401860807 0.110082348456383 0.709841595509588 -0.33431261367675 0.141713134609279 -0.224230265220367 0.359428826668445 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PROZ -0.190188557961056 0.820717067984475 0.946029511818221 -0.0722729509449691 0.933229881733644 0.981085441734921 -0.682435605937944 0.0777395433296845 0.527469221957405 0.124732922001436 -0.154966383980539 0.683152973380346 reversed False False False False False False False 0 insufficient_or_context_specific +TMPRSS2 -0.141561725129443 0.820895223172262 0.946029511818221 -0.2360250901357 0.70294314210888 0.891640364000942 0.892141647682586 0.160798809911724 -1.5862302904765 0.0121406469736717 -0.694088642793913 0.314378606518291 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP9 -0.0719284236847272 0.820935276161559 0.946029511818221 -0.17757021671323 0.572678630589559 0.827730374888659 0.876759679355806 1.0 False False False False False False False 0 insufficient_or_context_specific +ETV1 -0.108044472690591 0.821170666533941 0.946029511818221 -0.305111628339279 0.518973404197704 0.800840369846825 1.51653374558839 1.0 0.0952742725301883 0.84254452723701 0.322497795823582 0.307315771456057 0.41777206835377 0.231937134046773 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL12 0.0516117037860439 0.821216150800242 0.946029511818221 0.0081304929262947 0.971860887835757 0.992040338141303 -0.0774273534413366 0.824715143802762 -0.079887036333003 0.759537105322109 -0.15731438977434 0.565888059038065 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HSP90AB1 0.094060882378105 0.821356995191033 0.946029511818221 0.259740900661195 0.535098758337122 0.810930391494977 0.379166888784876 0.349693890765927 0.0691797751169031 3.0 -0.256900593102434 0.403777418851641 0.600182581594445 0.0346656998087498 0.343281988492011 0.209449647543205 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CCDC50 0.0293408195625834 0.821795543138284 0.946029511818221 0.0776561895446997 0.547045987741782 0.815603096463177 -0.0518765592601417 0.883360367629338 0.077951234707242 0.762718521261515 0.0260746754471003 0.93054528463141 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAL2 0.113166827243948 0.822003964427384 0.946029511818221 -0.0710534998545751 0.888991477459924 0.964276699808303 -0.218622308558258 0.615584556159232 0.28225665937357 0.406679800957896 0.0636343508153125 0.881095007660307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC048382.5 0.0728336011879266 0.822031142907704 0.946029511818221 -0.219929981879795 0.474364879350679 0.776724885585255 False False False False False False False 0 insufficient_or_context_specific +VIPR1-AS1 0.135866133414718 0.822137219924344 0.946029511818221 -0.0039847377989558 0.998079572265123 0.999215259242857 False False False False False False False 0 insufficient_or_context_specific +TMEM192 0.0591346058988512 0.822166689586356 0.946029511818221 -0.221650552906905 0.376813719165791 0.714146007197471 -0.381521712683029 0.43818386322322 0.458093241562806 0.239753238574875 0.076571528879777 0.876442792669679 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CD4 -0.0992183053307649 0.822180876671227 0.946029511818221 -0.263254045328432 0.549372386716146 0.816365047001981 False False False False False False False 0 insufficient_or_context_specific +GAR1 -0.060395767969616 0.822218794370358 0.946029511818221 -0.188060258905959 0.487511938844132 0.78238282774111 0.284850441902192 0.416228984019975 -1.03861948464106 0.0057344291286823 -0.753769042738871 0.0321406638843243 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GDAP2 0.0444496020478271 0.822418625668082 0.946029511818221 0.0616233465841212 0.755398449953978 0.914306641592812 -0.254604043797413 0.380491904675099 0.103505801164722 0.686137179965601 -0.151098242632691 0.57585981979015 partial_or_other True False False False False False False 0 cross_species_direction_conflict +UBXN2B 0.0598334937144521 0.822521246942296 0.946029511818221 0.0722781185154277 0.786537304110553 0.926121604088118 -0.085490105933651 0.872421025185575 -0.288059447538651 0.427111540167407 -0.373549553472302 0.348826813353645 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLS1 0.111195329124354 0.822575439579499 0.946029511818221 -0.0894648645672933 0.861035698798642 0.957532642502219 False False False False False False False 0 insufficient_or_context_specific +BEGAIN -0.0903024344701032 0.822591814520425 0.946029511818221 -0.182972390054908 0.648601879329086 0.86855377695836 False False False False False False False 0 insufficient_or_context_specific +SLC38A7 -0.0646561887333983 0.82295763647603 0.946029511818221 0.0163791576264968 0.95400263272356 0.987292667741163 0.562430620827215 1.0 -0.114972409447004 0.778731824221179 -0.0311761636325373 0.928882626857474 -0.146148573079541 0.671887853522916 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DOCK8 -0.0707546751898171 0.822961310837863 0.946029511818221 -0.396266498684281 0.203942232457622 0.577025563405608 0.18616285703137 0.591406277572281 0.131802592866705 0.63600989361415 0.317965449898075 0.276011964523011 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MGAT4A 0.0985810207118519 0.823040934670455 0.946029511818221 -0.0838929587989224 0.846084693940156 0.951935443160717 False False False False False False False 0 insufficient_or_context_specific +PSPC1 0.0360013122899689 0.823062017278789 0.946029511818221 0.112970365906109 0.479706009359467 0.780162456875056 -0.125080300817977 0.634935612993068 -0.120169167656649 0.57134695713164 -0.245249468474626 0.265979149348876 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RPUSD3 -0.0598110159010784 0.823108903830527 0.946029511818221 -0.0433080191401105 0.871194266797628 0.958683313195135 -0.409705696611819 0.293402531519531 0.323583222633372 0.323512227628202 -0.0861224739784472 0.82694027862204 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF25 -0.0608577577527875 0.823140025790712 0.946029511818221 0.0751143668830883 0.782596018636023 0.924647355053618 False False False False False False False 0 insufficient_or_context_specific +FAM161A 0.0873703075849788 0.823227518420633 0.946029511818221 -0.270095488759692 0.492638178861483 0.786325382313799 0.321733957116298 0.463502021830468 2.0 -0.0214056964564713 0.978775837181156 -0.200824432105228 0.706684431594126 -0.222230128561699 0.725123360083051 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASAP1 0.0517472958648231 0.823308092854062 0.946029511818221 0.28143501554826 0.208687268057133 0.58089116165231 0.5999773182409339 1.0 -0.0261159532402909 0.949262246032449 -0.24117001381659 0.384937206364341 -0.267285967056881 0.36182706243123 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GAS8 -0.0675186371576624 0.823318555929133 0.946029511818221 -0.238882698602955 0.429108936063849 0.748336221434264 1.47920596671374 1.0 -0.0646998183684602 0.899190663153417 -0.822777975603436 0.0321147489677723 -0.887477793971896 0.0338730135808966 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NAPB 0.0382474692896502 0.823576142861683 0.946029511818221 0.202832745542852 0.234551584635052 0.603410241368636 -0.0315947394791035 0.954454411339257 -0.520042760708218 0.150826116251216 -0.551637500187322 0.174237764252642 partial_or_other True False False False False False False 0 cross_species_direction_conflict +THAP3 0.0658676900049689 0.823646365978866 0.946029511818221 -0.192338210288818 0.506984673552613 0.793940104326385 -0.0808406415231801 0.826919418118464 -0.352800042394305 0.18009273088209 -0.433640683917485 0.126628974478663 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COPS6 -0.0684509031942285 0.823673420341393 0.946029511818221 -0.125843033259446 0.680714764119844 0.881087330028764 -0.107807932768839 0.795663869098636 0.51836042587022 0.0943553303255619 0.410552493101381 0.198633796590307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NR2C2 -0.0421415696780194 0.82396792465656 0.946049795848673 0.0877097757625909 0.644954981841701 0.866671082892285 0.258786113060229 0.343182196479811 -0.0232100278072339 0.93029383911543 0.235576085252995 0.341026039132025 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WASHC2C -0.0475264757055833 0.824007787476023 0.946049795848673 0.1138329344784 0.591289728163454 0.837852227882129 False False False False False False False 0 insufficient_or_context_specific +GALC 0.0560904342330153 0.82408354471342 0.946049795848673 -0.174479384665173 0.46552421259732 0.770973488128139 0.947011428151706 0.0570179712176716 -0.556668939608473 0.145316238686832 0.390342488543233 0.408110953926084 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF761 -0.0700593762968318 0.82409736431334 0.946049795848673 -0.189609410617878 0.536054071547373 0.811653361164085 False False False False False False False 0 insufficient_or_context_specific +MTERF4 0.04188515646441 0.824332321784642 0.946134143340989 0.10757108705727 0.579395978202145 0.831827949124047 -0.403624430131605 0.286903705465802 0.319765621513975 0.312686522905859 -0.0838588086176297 0.826646519991694 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TSHZ2 0.0493527674777622 0.824350064841235 0.946134143340989 0.127835968805212 0.556843159394119 0.820941061653668 0.704688125201212 1.0 -0.0998572083961741 0.810610902599311 0.58306524709769 0.0607667394414446 0.483208038701516 0.127599831688122 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MLF2 -0.0569458528782439 0.824449329792343 0.9461452199943 -0.0106540378270875 0.967310033359328 0.990962481293207 0.0219992785662378 1.0 0.0964183961161998 0.787647587732967 0.129255027998386 0.640579227213492 0.225673424114586 0.421375030668737 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LTBP3 -0.0505750839647028 0.824579939532412 0.946192261882753 -0.159804905235836 0.483186666766282 0.780666906162311 0.529084897678248 1.0 0.334811665483532 0.325400086697662 -0.754518310983133 0.0225009050116807 -0.419706645499601 0.179471292977265 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTFMT -0.057559681801311 0.824693074820735 0.94621160456417 -0.0024345726848282 0.992676854452226 0.998236115892821 0.866166163886073 0.25213261337738 -1.39227501105743 0.0375916467349194 -0.526108847171358 0.530240155469403 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF680 -0.0344856329656595 0.825018382850909 0.94621160456417 0.019951871401118 0.89737087332992 0.96776728096193 False False False False False False False 0 insufficient_or_context_specific +HS3ST3A1 0.123494937432477 0.825036149200582 0.94621160456417 0.423560297924809 0.452770873480055 0.76491545430188 0.431731279494957 1.0 -0.0971788794344041 0.828275929397972 -0.254205594692156 0.42023130444069 -0.35138447412656 0.298754480956859 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RSPRY1 0.0318599811511992 0.825077373512572 0.94621160456417 -0.005266175572289 0.97069147802279 0.992040338141303 0.283810925580117 0.233629641079493 -0.166404962866606 0.415899574998601 0.117405962713511 0.610519401148144 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IQCK 0.0491253553415131 0.825462527321115 0.94621160456417 -0.29735585727248 0.16637154382511 0.54636104500949 0.631276467994992 0.567755911976946 -0.608239788246927 0.434091539512716 0.0230366797480653 0.985414304713263 partial_or_other False False False False False False False 0 insufficient_or_context_specific +A2ML1-AS1 -0.0963449885470385 0.825588185097693 0.94621160456417 -0.165101761183523 0.704588114341821 0.89229234871308 False False False False False False False 0 insufficient_or_context_specific +SLC35E2B -0.0503876264329442 0.825609151325927 0.94621160456417 -0.263773727067613 0.234699381956706 0.603430771105967 0.25153951472125 1.0 False False False False False False False 0 insufficient_or_context_specific +TBP 0.0514614178733822 0.825673732210387 0.94621160456417 -0.0646829763541341 0.77714670516686 0.922929913000972 -0.0955857043963852 0.83289069999139 -0.466025471498295 0.147182631570478 -0.56161117589468 0.110968887064212 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADGRA2 -0.0866664819375868 0.825757993219653 0.94621160456417 0.178256694559976 0.648562635165385 0.86855377695836 0.330310172693869 1.0 0.681133027476357 0.0194526316654516 -0.574045061223394 0.0291264086024063 0.107087966252963 0.697358253233047 reversed False False False False False False False 0 insufficient_or_context_specific +IK -0.0815411767460468 0.82576186062268 0.94621160456417 -0.190970961540049 0.598314096728382 0.842680747516785 -0.159601423527772 0.590069725185064 0.178107679873 0.455387083192946 0.018506256345228 0.949455220911707 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC012414.5 0.0874449674808266 0.825918075561871 0.946287904696932 0.115954005102432 0.771940059010748 0.920816082141619 True False False False False False False 0 insufficient_or_context_specific +SAA4 -0.0997685099869804 0.826068941199115 0.946356623970145 -0.0829803393075001 0.855290978465366 0.955572714353157 -1.80181749160033 0.0002635483033429 1.758541264772 0.0007205935999067 -0.0432762268283232 0.903598804475437 reversed False False False False False False False 0 insufficient_or_context_specific +ABRAXAS1 0.0569786242901105 0.826230833189144 0.946356623970145 0.182357111408468 0.476932893712843 0.778277819446707 -0.302580996678628 0.59453779259082 -0.333860675338007 0.463530534137655 -0.636441672016635 0.195930967663878 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EAF1 0.075947943676707 0.826292699943685 0.946356623970145 -0.0506584845634487 0.888981768794732 0.964276699808303 0.9098452097243341 1.0 -0.0870945192444166 0.809937727594474 0.161241973644007 0.534688835450744 0.0741474543995907 0.808357610526879 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OTOGL -0.117607533114435 0.826470182715355 0.946356623970145 -0.41282135622015 0.434927666917616 0.75243712029294 False False False False False False False 0 insufficient_or_context_specific +FGG 0.086066481359538 0.826563620041648 0.946356623970145 0.531797343468116 0.165006551866568 0.545094551255265 -1.69222184967138 0.0016707522874818 1.16382037966112 0.0097435430573592 -0.528401470010259 0.173807826872228 reversed True False False False False False False 0 cross_species_direction_conflict +POMZP3 0.0614726231213712 0.826568538108996 0.946356623970145 0.137471732456951 0.630034520287996 0.85897526668397 True False False False False False False 0 insufficient_or_context_specific +RBM23 -0.0484694730471038 0.826672905908141 0.946356623970145 -0.368954789976682 0.105293933562105 0.482830329046451 False False False False False False False 0 insufficient_or_context_specific +UBOX5 0.0529581327046842 0.826771840553847 0.946356623970145 -0.0790087126300276 0.74888577540897 0.910671976140056 False False False False False False False 0 insufficient_or_context_specific +ZNF337-AS1 -0.0651176010772309 0.82686032163383 0.946356623970145 -0.380256081578593 0.205941410848705 0.578776160707106 False False False False False False False 0 insufficient_or_context_specific +PIK3CB 0.0376376473612032 0.826874394404678 0.946356623970145 0.102520118677876 0.55538913830644 0.820341147487324 0.253039051540321 1.0 -0.186116737279121 0.695875097989831 0.0412697447025621 0.919281653149987 -0.144846992576559 0.732755111122619 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SND1 0.0471319927214329 0.827058682641876 0.946383696383553 0.277187332334691 0.182535567598206 0.564667601143233 0.203087797525357 0.0817119558856647 2.0 -0.466686010451191 0.093386927305217 -0.0801150427369566 0.760575555362796 -0.546801053188148 0.0453556943546137 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL162586.1 -0.0823830174055836 0.827081813879177 0.946383696383553 0.0558893052871209 0.881470580259756 0.962618478946739 False False False False False False False 0 insufficient_or_context_specific +VPS4B -0.0408569007949855 0.827273622355243 0.946383696383553 0.0127691633550161 0.945154615215563 0.985282625142764 -0.130208035880128 0.754402743944709 -0.0300748963746501 0.931942990277106 -0.160282932254778 0.647294767125471 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC004918.1 -0.0641946624069378 0.827323526527495 0.946383696383553 0.104667012569026 0.723907236420294 0.902378599287888 False False False False False False False 0 insufficient_or_context_specific +PDLIM7 0.0877715974720764 0.827346232015552 0.946383696383553 -0.0236085723172829 0.953049091025044 0.987149466215884 0.344804591423282 0.155047158435843 0.0922477713297583 3.0 0.729837935581682 0.122275635563243 -1.40487347511144 0.0068126806499036 -0.67503553952976 0.130212706439522 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKMY1 0.0470502974448979 0.82761948426721 0.946593707604074 0.172658803715483 0.41617781639238 0.737620511242362 0.313149634905591 1.0 True False False False False False False 0 insufficient_or_context_specific +STX18 0.038522264026612 0.827728437779318 0.946615776221191 0.125401323739997 0.473333407490879 0.776002191970296 -0.384495666719987 0.176046001729535 -0.0630302030275097 0.816189405784231 -0.447525869747497 0.0967652763085884 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GSDMB -0.066921801669408 0.827831760680436 0.946631401414929 -0.0796830401586095 0.795628496807626 0.928705441354941 False False False False False False False 0 insufficient_or_context_specific +TGFB1I1 0.0685710327621407 0.828643961591259 0.947127722307772 -0.298835506959726 0.33691060172471 0.685057785656405 0.007990171540405929 1.0 0.832765851433696 0.0697619153098527 -0.692360223941146 0.0821757450519655 0.14040562749255 0.766676941718105 reversed False False False False False False False 0 insufficient_or_context_specific +ZNF549 -0.0638640195249972 0.828695151178225 0.947127722307772 -0.111301104639585 0.706182226776123 0.892947759038953 False False False False False False False 0 insufficient_or_context_specific +AASS 0.114037955187265 0.828878191665812 0.947212463211132 -0.33566152459654 0.518059609336416 0.800840369846825 -0.906957587732224 0.136069358034473 1.28785997145959 0.0261109460082666 0.380902383727368 0.488574273351361 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00476 -0.0549999917892196 0.829136397001151 0.947343365800488 -0.246082658508422 0.321881858850222 0.672877524535327 False False False False False False False 0 insufficient_or_context_specific +LONP2 -0.0359921020402155 0.829230847160846 0.947343365800488 -0.0090066828520113 0.957043346843345 0.987656798648419 -0.402287303929591 0.306828401090083 0.913697698243551 0.0180336972888686 0.51141039431396 0.152502156828522 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP1R8 -0.0542239221651279 0.829408359347699 0.947343365800488 -0.185023321668348 0.456096680346516 0.767060408474954 -0.0070031309871451 0.988784489626864 0.035492347967589 0.921435776301235 0.0284892169804438 0.94210715445504 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC022893.1 -0.0472676997211338 0.829466624721679 0.947343365800488 -0.0672831635485405 0.759611514372182 0.915406319729464 False False False False False False False 0 insufficient_or_context_specific +HP1BP3 0.0367720639287709 0.829579196664693 0.947343365800488 -0.0547035673863039 0.74882300651844 0.910671976140056 0.574382732267844 1.0 -0.0327838581185133 0.926036002722158 -0.0596655893977053 0.818458221583827 -0.0924494475162186 0.73451322748853 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MKNK1 0.0402227533672537 0.829600047234592 0.947343365800488 0.0003382423516251 0.998464519297592 0.999257679999277 -0.126304276421314 0.777386064339247 -0.552551079283982 0.102669069808065 -0.678855355705296 0.0695856135977798 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MCMBP 0.0575949869494218 0.829710561049168 0.947343365800488 -0.0515277665023202 0.84561036749976 0.951604589646394 0.161793488373775 1.0 -0.516847649915409 0.0297321086136799 0.245262945976509 0.221306890614896 -0.2715847039389 0.196286811450474 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EXOSC7 0.0769948830938668 0.829913205960294 0.947390862776809 0.276584046162395 0.440242071160654 0.756769095948255 -0.228327128408291 0.396071740154278 -0.149702673313742 0.515930300530224 -0.378029801722033 0.12263697199252 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LMO4 0.0544144300112203 0.830004782929843 0.947390862776809 -0.157596677781275 0.516518331362713 0.799736111237355 0.0677694472125188 1.0 -0.144402084032885 0.699390389220857 -0.145938771768131 0.626366748458206 -0.290340855801017 0.343744562407399 partial_or_other False False False False False False False 0 insufficient_or_context_specific +XPO1 -0.0353779972206953 0.830057427343274 0.947390862776809 0.0963784693410209 0.557490148874097 0.821146901759586 0.01923514644563 0.5185276723498561 2.0 0.0811469757248064 0.832591131318639 -0.174721479695988 0.524294819378626 -0.0935745039711813 0.768605722344055 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BAIAP3 -0.10969390516748 0.830191818254471 0.947390862776809 -0.0444109773292379 0.935594557340304 0.981714106181567 False False False False False False False 0 insufficient_or_context_specific +PTPN14 -0.0458076076257742 0.8304530580661 0.947473890972756 0.117301731123653 0.584565772977028 0.83427397074951 0.0272161445050927 0.948978490920634 -0.126001892591656 0.661208120838912 -0.0987857480865634 0.766676941718105 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CUBN -0.0743496195581894 0.83072625734363 0.947519797193681 0.0957558194251144 0.785341387286545 0.925715570723606 0.6703091162797951 1.0 False False False False False False False 0 insufficient_or_context_specific +ZFYVE27 -0.043282073478915 0.830839867804851 0.947519797193681 0.022816602483879 0.909375648003666 0.971583494396145 -0.104640238011761 0.727190108818436 -0.438636376892392 0.0668306776535532 -0.543276614904153 0.0396757426500509 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC087762.1 -0.0980390947866757 0.830966393133823 0.947519797193681 -0.374775543294894 0.407318269109375 0.734118519162987 False False False False False False False 0 insufficient_or_context_specific +ARHGEF28 -0.069650883148271 0.830994087524528 0.947519797193681 -0.195345939352871 0.554308783941901 0.819814244898102 0.753010130385015 0.831005669699954 2.0 False False False False False False False 0 insufficient_or_context_specific +AC096711.2 0.0635924006698226 0.8310317599937 0.947519797193681 0.214391568750681 0.48617525220895 0.782071323676502 0.0312760071088312 1.0 True False False False False False False 0 insufficient_or_context_specific +ZDHHC20 0.039828345933716 0.831307570952278 0.947606925285218 -0.0480558283722256 0.790696022210343 0.92749893235615 0.0348268282411638 0.93748803932992 -0.478841801212745 0.114153228084674 -0.444014972971581 0.169388078292199 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM248 -0.0484916885955806 0.831521721380493 0.947606925285218 -0.0061352426486367 0.978438219893994 0.993685140981223 0.432375135510545 1.0 -0.528100658527262 0.0863949048222456 0.50941899755147 0.0661552037124177 -0.0186816609757913 0.95465402980089 reversed False False False False False False False 0 insufficient_or_context_specific +BACE1 -0.0432238214585827 0.831796352921737 0.947606925285218 -0.077818944465828 0.701061758551447 0.891032869481905 -0.0970690641638353 0.816326782498487 -0.0057805671876264 0.987380618750829 -0.102849631351462 0.769732992554821 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ILK -0.0469189876674515 0.83181798695312 0.947606925285218 0.0375297312570113 0.864132043575943 0.958391272020028 0.0813521462528015 0.774267546969046 0.182133030348488 0.389395070838706 0.263485176601289 0.234570078976792 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF786 -0.0745609759102978 0.831824320420869 0.947606925285218 0.0018218765367318 0.994497503742165 0.998754365500787 False False False False False False False 0 insufficient_or_context_specific +NUP160 -0.0327803754402567 0.831826196584903 0.947606925285218 -0.0755612801974045 0.618695639181416 0.853546133343446 0.276477823932895 0.408982814243201 -0.240371427414854 0.367410750397757 0.0361063965180411 0.919451015072109 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VCPIP1 0.0466299460108697 0.831972250653346 0.947622853574664 0.113623250276859 0.608809481318698 0.848011761873084 -0.206183275891766 0.532838321757823 0.157049462452503 0.56101181686048 -0.049133813439263 0.881976058535028 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RUFY2 0.0354928043585482 0.83201968674343 0.947622853574664 0.177362570887993 0.296868473526565 0.654889895570548 -0.0237111858178321 0.96322980620288 -0.614887134080939 0.0881971107941771 -0.638598319898771 0.0998586740781981 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HOOK1 -0.105671705187364 0.832281927787122 0.947717061429727 -0.28895040029096 0.556883868494371 0.820941061653668 -0.720194770905595 0.0720996796071116 0.425871337810055 0.217375669095478 -0.29432343309554 0.418053378097989 reversed False False False False False False False 0 insufficient_or_context_specific +AC097376.2 0.0480542789167265 0.833078582341223 0.948225126875272 0.0859710549194761 0.705543107105415 0.892859178331413 True False False False False False False 0 insufficient_or_context_specific +GARNL3 -0.0439692267895716 0.833239453767942 0.948225126875272 -0.039869423620152 0.848455485919736 0.953127856970211 0.41553263760458 1.0 False False False False False False False 0 insufficient_or_context_specific +KLHL5 -0.0429907090027653 0.83323993476904 0.948225126875272 0.166445238579983 0.385072188402631 0.719652702248211 0.248225744816968 0.426790276800845 -0.213849613578766 0.410629770823586 0.0343761312382018 0.917113143865285 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EP300 -0.0279689321090541 0.833384030465338 0.948225126875272 -0.109360173565356 0.408714317340461 0.734801770489731 0.0001338900395729 0.999592852268872 0.168107459749871 0.449746237891013 0.168241349789444 0.486554567182243 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTN 0.0794885918257979 0.833771895877659 0.948225126875272 -0.210480535021835 0.569007700385529 0.825557688700071 -0.0597738076064436 0.935285427653295 -0.819908410598242 0.102988915954324 -0.879682218204686 0.123223536721075 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF18 -0.0671420493345521 0.833846777226119 0.948225126875272 -0.0998213308145398 0.748711598830586 0.910671976140056 False False False False False False False 0 insufficient_or_context_specific +SLC27A2 0.115730025450203 0.83396300185766 0.948225126875272 -0.0024359819214415 0.996774078759822 0.998795540446485 -1.22535643371635 0.0467178854391742 1.79939215105989 0.0068062543499503 0.574035717343538 0.292318017000595 reversed False False False False False False False 0 insufficient_or_context_specific +ICE2 0.0333095663402829 0.833974810851568 0.948225126875272 -0.0513529434602379 0.744711521198571 0.909500945159707 0.555737135912228 1.0 0.0811590507709791 0.862435148401668 -0.237447197496918 0.455387083192946 -0.156288146725939 0.677984706224116 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AK4 -0.0828107396715671 0.83402297158122 0.948225126875272 -0.212545472226387 0.589623613230694 0.836839105859613 0.0214557556610675 1.0 -0.585844892684462 0.360603358387762 0.91930311608771 0.0863419788520437 0.333458223403248 0.56131520805434 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00937 -0.085300409340549 0.83410945605929 0.948225126875272 -0.175521702673554 0.6635060916009 0.874384483010807 False False False False False False False 0 insufficient_or_context_specific +EFCAB11 -0.0651276335051199 0.83444200518436 0.948225126875272 -0.0503930780249193 0.871545803700869 0.958683313195135 6.80588403115192 0.0044059160353903 -3.4728268073104 0.0046641092992809 3.33305722384152 0.260265783751745 reversed False False False False False False False 0 insufficient_or_context_specific +NBPF14 0.0530651733477733 0.834445316283513 0.948225126875272 0.0377196013090389 0.882030879086424 0.962655003796147 True False False False False False False 0 insufficient_or_context_specific +KIF9-AS1 0.0429596462239458 0.834592088212604 0.948225126875272 0.205988468302181 0.303052696201391 0.660262147440009 True False False False False False False 0 insufficient_or_context_specific +RAB30-AS1 -0.0375725654027013 0.834733178937342 0.948225126875272 -0.2581798197347 0.132225206167848 0.518682589655195 False False False False False False False 0 insufficient_or_context_specific +LUC7L3 0.0354850670441757 0.834741045507935 0.948225126875272 0.0058609418884373 0.972382004517856 0.992040338141303 -0.121510866780225 0.759455697445548 -0.559013832298387 0.0734289625694585 -0.680524699078612 0.0436288602350513 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SEMA3D 0.118913485912175 0.834894034503849 0.948225126875272 0.41965644668871 0.456489561840689 0.767088459957662 -0.375390170928594 0.320349903765884 0.0445506530136328 0.906123521623629 -0.330839517914961 0.333790661942985 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF138 -0.0439537895860406 0.834955641050492 0.948225126875272 -0.0072256051433306 0.972453473659287 0.992040338141303 False False False False False False False 0 insufficient_or_context_specific +FUBP3 -0.0276838113074536 0.835276122543571 0.948225126875272 0.0083631254493611 0.949812712019386 0.986917609553614 0.126033689331571 0.714168325030578 0.0393401180476337 0.894471208626662 0.165373807379204 0.569094169095461 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC2A10 -0.0491833661665586 0.835343477429846 0.948225126875272 -0.13982803917899 0.551313472258275 0.817770107102835 0.0470632023002095 1.0 1.28166108165519 0.166305489093368 -0.883366519597725 0.188208108714278 0.398294562057468 0.69469544116432 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRMT13 0.0312666715420218 0.835370669508773 0.948225126875272 0.093743283678148 0.5337542956313 0.810472587529927 -0.0151812744960614 0.97100168852273 -1.11280537627514 0.0039566153281876 -1.1279866507712 0.006351445639828 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TCEANC2 0.0693013074954488 0.83540391916409 0.948225126875272 0.0719651801644488 0.829433162375306 0.942947704141109 -0.214577504061542 0.731535646915491 0.204596325164331 0.665557838069379 -0.0099811788972107 0.987117818319959 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRPH2 -0.0610626434643705 0.835422440821537 0.948225126875272 -0.0033653747802688 0.992846888898514 0.998236115892821 False False False False False False False 0 insufficient_or_context_specific +ANKHD1-EIF4EBP3 0.0482805609555415 0.83557027160934 0.948290973626938 0.0392156289450238 0.865716200819519 0.958391272020028 True False False False False False False 0 insufficient_or_context_specific +TSPYL4 0.0578979695334423 0.83585009946059 0.948302745551785 0.209060365567522 0.451886945766151 0.764220781091034 1.61533753611964 1.0 -0.653440726978896 0.0939689646649818 0.29175346374209 0.387528998363468 -0.361687263236806 0.308147985630594 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FANCM 0.0586099130059208 0.836067063380664 0.948415305066142 -0.237770994951804 0.404957489773953 0.733368984053757 -0.0462981260619715 0.944136399773005 -1.09272621622808 0.0298692100204452 -1.13902434229005 0.0391189027988772 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UCHL3 0.0521415793805388 0.836154259239754 0.948415305066142 0.0156237337583785 0.951168427734243 0.986917609553614 -0.175102320114603 0.743776127497033 0.385034388685432 0.295079522499574 0.209932068570829 0.632527494953755 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRPF31 -0.060940695090093 0.836351881854128 0.948464357531244 -0.441130612060266 0.117243011375629 0.4969296323179 0.171698377793864 0.60497543431949 -0.298476295975731 0.243244339459994 -0.126777918181867 0.678553127833005 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HOXB2 -0.0675986382613535 0.836522501188467 0.948549895877846 0.548591362359086 0.138838156923734 0.524067528467748 1.27963504235719 1.0 0.856063006439566 0.14059859534604 -0.356456567918338 0.448736342079245 0.499606438521228 0.358851431199118 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBRS -0.0552804489000172 0.836606992840927 0.948549895877846 -0.0654590634015318 0.806898609006535 0.932788199072101 0.0374758168885645 1.0 -0.087838767475664 0.72189463408318 -0.329030261226032 0.0923676798660251 -0.416869028701696 0.0500810439963955 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNRPA -0.0436258740161887 0.836953737205619 0.948717540962526 -0.0816417997759289 0.699267800070966 0.889654761580003 0.530058937045744 1.0 0.0704345305403575 0.848726472302442 0.0375392228306475 0.900241012403475 0.107973753371005 0.714871734867846 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRF -0.0830652258419184 0.837024426412761 0.948717540962526 -0.162650128756728 0.688999190828915 0.884999569552245 0.320242234817909 0.4932284500519121 2.0 -0.0728704356914138 0.83289069999139 -0.688850843833716 0.0154593179240643 -0.76172127952513 0.01475632710262 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MT1X 0.125082695508781 0.837128050432813 0.948723990252249 -0.115084646938465 0.849226433647248 0.953127856970211 0.0245573180311363 1.0 False False False False False False False 0 insufficient_or_context_specific +FN3KRP 0.0566424397633654 0.837340955313403 0.948723990252249 0.0173676358347608 0.948902000011089 0.986850602454401 -0.488313515001031 0.117376574436309 0.44910541136787 0.0961510842298932 -0.039208103633161 0.906058802680816 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL139011.2 0.0564898416937153 0.837379466851254 0.948723990252249 -0.0537933536114828 0.842847205754366 0.950469545398617 False False False False False False False 0 insufficient_or_context_specific +SPTY2D1 0.0626340715372874 0.837389549645834 0.948723990252249 -0.138633589401723 0.642731021436969 0.865003712470557 0.345946396090295 1.0 -0.0913002427756125 0.799432220701195 -0.372841292035023 0.157256188165771 -0.464141534810635 0.103736448352169 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOP58 0.0398955980021456 0.837508396388678 0.948756829299535 -0.0843404142218609 0.667124398175131 0.875419277100913 0.504334994928824 0.0982268555740713 2.0 0.123115300061057 0.719214521019672 -0.29624354425965 0.250910392550885 -0.173128244198593 0.551979607096428 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AMMECR1L 0.0593807144172265 0.837864803678663 0.948992055615846 -0.0657104420212898 0.818534861679711 0.937320072626289 -0.147112115620318 0.597774722621014 0.145598925593519 0.515303978941256 -0.0015131900267998 0.996322165464507 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NNT 0.0416508310153298 0.837895808150305 0.948992055615846 0.342205307072713 0.0814369692366781 0.461068439742811 0.290002079521937 1.0 -0.342246764382253 0.158112051262977 -0.0683767576208455 0.763276683201078 -0.410623522003098 0.0772261263654318 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZMYM3 -0.0785760566389945 0.838110207668597 0.949047382282711 -0.126475299010282 0.742967244913926 0.909273715761109 0.5581216819156409 1.0 0.00126200931989 0.99714076360711 -0.58205516513092 0.0423308191380229 -0.58079315581103 0.0570203195224765 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABL1 -0.0356189363958153 0.838124435726842 0.949047382282711 -0.128441489759045 0.445494145681992 0.760927015161427 0.6199144895733371 0.5279105170884689 2.0 0.240812541518249 0.371697360742078 -0.269295134406204 0.238178461086442 -0.0284825928879545 0.92087061297149 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF12 0.0443593706747993 0.838319969292134 0.949063086873091 0.241582088766011 0.268824017627459 0.632971449177233 True False False False False False False 0 insufficient_or_context_specific +AC020916.1 -0.117321736948822 0.838346113256038 0.949063086873091 -0.0625529135245203 0.915325936543324 0.974759629076879 False False False False False False False 0 insufficient_or_context_specific +USP11 0.0637018829200089 0.83849494774431 0.949063086873091 -0.305611541224755 0.309429318427557 0.662858728430055 0.0014079166482427 0.997208312470331 -0.95956589089218 0.0106372341205074 -0.958157974243937 0.017406843319324 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AZIN1-AS1 0.0552925956421605 0.838877456407951 0.949063086873091 0.0047609499768442 0.98613343844346 0.995662563940518 True False False False False False False 0 insufficient_or_context_specific +SLC2A9 -0.0786535276981931 0.838881366205063 0.949063086873091 0.0892057896333214 0.816315593359848 0.936230700610385 0.7812472391119809 1.0 -0.589004129188132 0.239739691805785 0.656723462972435 0.119402558055905 0.0677193337843027 0.896173185721066 partial_or_other False False False False False False False 0 insufficient_or_context_specific +B3GNTL1 -0.0580872857524756 0.838887174891056 0.949063086873091 -0.0385713892420716 0.893039952242496 0.965661185556767 0.451499746440224 1.0 -0.321580477803096 0.363971745708548 -1.04441007285592 0.0070995430580289 -1.36599055065901 0.003720919926498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MSRB2 0.0578876327065078 0.838976593201283 0.949063086873091 0.0328501917284988 0.907405811838524 0.971275673886815 0.52766889107561 1.0 -0.0792771126353274 0.900364871566824 -0.0330191955347365 0.944232845024125 -0.112296308170064 0.826577890555824 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SETD2 -0.024610250015029 0.839300305605888 0.949157307903488 0.0630799738964206 0.609303343662933 0.848013066172034 0.354182199565039 0.171260636207483 -0.0591539117720695 0.803778785038109 0.295028287792969 0.217485762928873 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC118549.1 0.033264184126257 0.83943639834004 0.949209542002157 0.0997144159364504 0.538145036818348 0.812087893451657 True False False False False False False 0 insufficient_or_context_specific +EML2 -0.0463291607137145 0.839594242774574 0.949286358450841 -0.0462990456782826 0.839642479290104 0.948528279086767 -0.40214105676402 0.303722119312339 0.252659908182987 0.448241735857466 -0.149481148581034 0.694312956614556 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EFCAB13 -0.0565304060687059 0.839814051155228 0.949433210418342 0.0650247962828146 0.819691296146316 0.937645994477492 0.8516849843622221 1.0 False False False False False False False 0 insufficient_or_context_specific +GALNT18 -0.0708486219093871 0.840004029809343 0.949546311212746 -0.119230781287203 0.734431403114668 0.904977889122883 -0.284744271398968 0.683195025403785 -0.247499965084863 0.652937186610457 -0.532244236483831 0.361825344263103 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TLN2 -0.054853712295225 0.840404463518808 0.949795581870218 -0.460934608032829 0.082401168342896 0.462431570888118 -0.640305205216026 0.0606656035367738 0.505911864133516 0.0946184192410373 -0.13439334108251 0.685035523624829 reversed False False False False False False False 0 insufficient_or_context_specific +IP6K3 0.107142441239871 0.841252409314073 0.950376610463724 -0.125064023962856 0.821567334104769 0.938654681687929 0.7854502042930479 0.365274446117366 2.0 False False False False False False False 0 insufficient_or_context_specific +ZNF852 0.0840808333763512 0.841255741769811 0.950376610463724 -0.275912999908332 0.490528986294627 0.785169491036864 False False False False False False False 0 insufficient_or_context_specific +FAM210A -0.0518858735750195 0.841498420641679 0.950376610463724 0.152446398253165 0.559857840387012 0.822111137525184 -0.813549317033908 0.0179789878427023 1.07006751198006 0.0038510740420548 0.256518194946152 0.376347681861329 reversed False False False False False False False 0 insufficient_or_context_specific +BRD8 -0.0432112337820925 0.841561350103682 0.950376610463724 -0.257414205125157 0.229454075095603 0.600837332554409 -0.0537602728081792 0.885130826731918 -0.568940250026421 0.0407878298379236 -0.622700522834601 0.0355956608625232 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USP35 -0.0801805397555655 0.84162785067376 0.950376610463724 -0.164707948287283 0.676927363467545 0.879522409979121 0.146684730135802 0.779396061400076 -0.83327038712669 0.0462001703007066 -0.686585656990888 0.110931720806822 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHMP7 -0.0646296448969175 0.841726593873167 0.950376610463724 -0.355484318716174 0.279771020602565 0.642114507827558 0.266812608129784 1.0 -0.0194695025245366 0.948978490920634 0.0934509117155009 0.655229888500466 0.0739814091909643 0.752373821344479 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS30-DT -0.0655569732357879 0.841781046997743 0.950376610463724 0.362371809138531 0.293626689054283 0.652324662738756 False False False False False False False 0 insufficient_or_context_specific +SIDT2 0.0628712173274176 0.842145290363955 0.950376610463724 -0.275914711740495 0.388568517139301 0.72189097377384 0.6921999887291379 1.0 -0.125665875602234 0.67527450784124 -0.0332349082779176 0.902660460420492 -0.158900783880151 0.53123143819099 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTCD2 -0.051895297361278 0.842314044072669 0.950376610463724 0.001488634790344 0.995945501438557 0.998795540446485 -0.190402376280926 0.619519226369392 0.0418656182895447 0.904210548761399 -0.148536757991381 0.665991751166941 partial_or_other False False False False False False False 0 insufficient_or_context_specific +YARS -0.0384516622746082 0.842414055826379 0.950376610463724 0.0606844860466797 0.747564107035915 0.909830759894547 0.193029104320953 0.680138276447243 -0.0484498187829783 0.90608511988179 0.144579285537974 0.729325123969586 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DDX10 -0.0342561832868151 0.842431701232862 0.950376610463724 0.0527038915002296 0.756151951877761 0.914440101763119 -0.148350112698797 0.619519226369392 -0.0348802321379661 0.899641920992852 -0.183230344836763 0.471712285135428 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP3K7CL -0.080844625635143 0.84248021583562 0.950376610463724 -0.0655407028459793 0.872273360993744 0.958919423716363 0.467419116336133 1.0 False False False False False False False 0 insufficient_or_context_specific +CXORF38 -0.0468206835388547 0.842645525508074 0.950376610463724 0.0509809106427808 0.822057923271786 0.938808681069134 0.351795652198763 1.0 False False False False False False False 0 insufficient_or_context_specific +WDR70 0.0257200502783125 0.842720110118063 0.950376610463724 0.0506095425795798 0.694202461384011 0.887432585446834 0.00106229996209184 1.0 -0.231424559751546 0.426737081292997 -0.31945047934764 0.19402488000134 -0.550875039099186 0.0473736748509004 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CYP4X1 0.0903941159979209 0.842749068380202 0.950376610463724 0.331457366568539 0.470763975342923 0.774676753689306 0.523604269400432 1.0 True False False False False False False 0 insufficient_or_context_specific +DBF4 -0.0520465976552233 0.842956158699438 0.950376610463724 -0.0521679809793318 0.842759594998484 0.950469545398617 1.18641614773411 0.055268184163693 -1.50010455435423 0.0102391053289871 -0.313688406620124 0.648794012332732 reversed False False False False False False False 0 insufficient_or_context_specific +APEX1 -0.086990788649185 0.843135461329115 0.950376610463724 0.137877288116077 0.746606110585752 0.909830759894547 0.0885585831239721 1.0 0.195453079674717 0.555616718424366 0.22013192096071 0.380345328313157 0.415585000635426 0.142168561277023 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UTP3 -0.0680851052540476 0.843338345407361 0.950376610463724 -0.209991691648436 0.51998355896481 0.801118945922776 -0.33946183213379 0.294828770942588 0.218815151766194 0.43009841533492 -0.120646680367596 0.704019087595202 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRSF1 0.05252779300695 0.843644543384951 0.950376610463724 -0.180604768134996 0.483033507652203 0.780666906162311 0.538942963057611 1.0 -0.074979728796444 0.842120288450274 -0.717140476202954 0.0185781377373433 -0.792120204999398 0.0166226573127459 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRDMT1 -0.068118568131878 0.843671371354942 0.950376610463724 0.0993114250704372 0.778409005173618 0.922929913000972 -0.352549428024652 0.514723341628365 0.0180320858351613 0.970762951952572 -0.334517342189491 0.480705412567541 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UFD1 -0.0424838285534232 0.843695388383545 0.950376610463724 -0.102481329306842 0.625673608237484 0.856624485564009 -0.248707520977739 0.372726683952116 0.128665168185974 0.595099371306616 -0.120042352791765 0.652513316517144 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPSB1 0.106156025689092 0.843758854816332 0.950376610463724 -0.0390912382799201 0.942164201281834 0.984366565940656 0.407698837541774 0.422146397118666 0.169471841619564 3.0 -0.104243474371333 0.81310596327621 0.109121949478302 0.746711467176359 0.0048784751069698 0.990498624561998 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RSBN1 0.0370019276652933 0.843878982953727 0.950376610463724 0.0097922844390223 0.958119562035052 0.988066647388755 0.301305397399696 1.0 -0.411086297565044 0.221094369266366 -0.051233234460581 0.87880636069971 -0.462319532025625 0.141460434116321 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ERGIC2 0.0397261953290578 0.843983460842287 0.950376610463724 0.218326453593596 0.27980385314843 0.642114507827558 -0.328234071016841 0.217903955746435 -0.263244225363539 0.258057477710361 -0.59147829638038 0.0305134781637063 partial_or_other True False False False False False False 0 cross_species_direction_conflict +DOCK11 0.052491824501149 0.844012973956788 0.950376610463724 0.347787341108616 0.187849500382644 0.56929178900529 True False False False False False False 0 insufficient_or_context_specific +AL157911.1 0.0623856850692497 0.844075613893814 0.950376610463724 0.413500006840191 0.190031579729686 0.569886897607216 True False False False False False False 0 insufficient_or_context_specific +HSPA12A 0.0518304055879832 0.844341269390478 0.950376610463724 0.366719475693413 0.15188846914695 0.534368029741253 -0.669248982781279 0.0769830561162859 0.514112638020759 0.1167268963665 -0.15513634476052 0.669941316263452 reversed True False False False False False False 0 cross_species_direction_conflict +NUMB 0.026951540341347 0.844404011544667 0.950376610463724 0.148387736139434 0.270490218167344 0.634531964851516 -0.137115488133341 0.596466975369561 0.469654503841428 0.0351264831686747 0.332539015708087 0.130175783253176 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NFIA -0.0378378631578396 0.844459321707959 0.950376610463724 0.0104017053204927 0.957105504710992 0.987656798648419 0.281269611208612 1.0 -0.0410663228499636 0.917945009132389 0.326969212138609 0.22415525301189 0.285902889288645 0.310100188256524 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SHC3 0.0917390359357332 0.844642894443551 0.950376610463724 0.768084782703884 0.115445176778998 0.493786316225751 1.08641569818993 1.0 True False False False False False False 0 insufficient_or_context_specific +VSIG10 0.0542905385423961 0.844691235365418 0.950376610463724 -0.159410525928737 0.576266367681752 0.829930474694303 0.328589525986201 1.0 0.0629601563655784 0.905790421240866 -0.295290431635075 0.400838528143754 -0.232330275269496 0.562668391096397 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL391807.1 0.0835754630075297 0.844882267743875 0.950376610463724 -0.0562148108826052 0.892297572721361 0.965368150296491 False False False False False False False 0 insufficient_or_context_specific +SGSH -0.0806453226221896 0.845088357474866 0.950376610463724 -0.0381674829232894 0.927325648502052 0.979087152943213 0.9775220133328141 1.0 0.55083937422562 0.290741075619055 -0.133683491268054 0.762794436596395 0.417155882957566 0.385315368788161 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC145124.1 0.0871641952016145 0.845163136293715 0.950376610463724 -0.283903247483618 0.506788803107087 0.793868869911665 False False False False False False False 0 insufficient_or_context_specific +FNDC3A 0.0317157988246188 0.845269942713218 0.950376610463724 0.185432298633697 0.235474094595232 0.604719389411913 -0.332642581908089 0.175099670205399 0.0749402910711011 0.743719736195366 -0.257702290836987 0.253404656990297 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FLYWCH1 -0.045311253642497 0.845491477135883 0.950376610463724 -0.0757072806149532 0.743431606628868 0.909330581150367 0.162565637239978 1.0 -0.30659245802971 0.270169613609133 -0.0924157183894026 0.717981479287586 -0.399008176419113 0.122913663179657 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DLC1 -0.0433890073177014 0.845911099635766 0.950376610463724 0.116921753854295 0.587535801952706 0.835274227991216 0.268519261740066 1.0 0.25118949638138 0.28412330181092 -0.0626252967296574 0.773441665005625 0.188564199651722 0.379881921891787 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBMS3 0.0465545339729861 0.845971237813914 0.950376610463724 0.110456490257142 0.644153000276884 0.866251949351307 0.359870378231652 0.5546369854059671 2.0 -0.033872447012072 0.946035128307368 -0.606051084087136 0.0824072485483195 -0.639923531099208 0.0806748687587081 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MECR -0.0463290301118585 0.845995217805124 0.950376610463724 -0.0806316500707938 0.734368325924748 0.904977889122883 0.8590724961845501 1.0 -0.306672846808814 0.271924106769673 0.261071387400633 0.271505800500981 -0.0456014594081814 0.877419321934288 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARRB2 -0.0746092120909036 0.846045478505182 0.950376610463724 -0.111693210954245 0.770510668036391 0.920631444062254 0.277107903804116 1.0 -0.125073441894991 0.777384451088073 -0.548127923573984 0.10429959522678 -0.673201365468975 0.0663462744017243 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF2D -0.0449009453230834 0.846147966173269 0.950376610463724 0.126674643098982 0.590737835530237 0.837519815701388 0.67794429816923 1.27542621303417 2.0 0.0003514562787018 0.99931014544354 -0.22040598024653 0.48629335484163 -0.220054523967828 0.533092878419051 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF780A 0.0592267271887667 0.846382954519062 0.950376610463724 -0.0816255485709111 0.784906941974801 0.925705787798454 False False False False False False False 0 insufficient_or_context_specific +BEND7 0.0492767518057894 0.846439757284504 0.950376610463724 0.139485708548706 0.590209997869234 0.836996260242226 True False False False False False False 0 insufficient_or_context_specific +B4GALT5 -0.0473995853871506 0.846821200728836 0.950376610463724 0.216074805364211 0.367946703317554 0.708317354196916 0.283540205720212 1.0 0.245746083360667 0.521218168225128 -0.457222874462381 0.148760823451189 -0.211476791101714 0.540180951391 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC008537.1 -0.0591717388219859 0.846822651593153 0.950376610463724 -0.0300059084175085 0.922147394252822 0.977317023541587 False False False False False False False 0 insufficient_or_context_specific +TMEM176B -0.061065207257179 0.846908888270781 0.950376610463724 -0.170914282623868 0.583781877154663 0.834132995585234 0.351093080799498 1.0 0.148441915278448 0.707255249318336 0.105242320523473 0.750652694006661 0.253684235801922 0.435883614454644 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LSM7 -0.0744362431167756 0.847130002792171 0.950376610463724 -0.371811517061116 0.329650375695809 0.678186271926176 -0.0837121341097178 0.786676935372497 -0.13427127068708 0.560637026083447 -0.217983404796798 0.369225824553017 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC43A2 0.0827527504947065 0.847291544636355 0.950376610463724 -0.0422106345261335 0.923577258138272 0.978025243014285 1.51869027174113 1.0 0.317550974596518 0.522045968767996 -0.0378094908496576 0.931942990277106 0.279741483746861 0.527888370701941 partial_or_other False False False False False False False 0 insufficient_or_context_specific +METTL9 0.0444789906596958 0.84736050052534 0.950376610463724 0.0077007431961723 0.973598587809641 0.992397556487178 -0.0922914756893569 0.777061678052549 0.404660686468065 0.0940870464662318 0.312369210778708 0.216959511603848 partial_or_other True False False False False False False 0 cross_species_direction_conflict +UBE2Q2 -0.0398762675535334 0.847435861294282 0.950376610463724 0.154693207975311 0.459730658897472 0.768558565184993 0.0238930568901999 0.958178300525437 0.384444707414066 0.186680018338252 0.408337764304266 0.205941723654141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPRASP1 0.070914818981844 0.847691139206922 0.950376610463724 -0.0245389972467892 0.94612218560008 0.985432868134933 0.216887176144841 0.535850100457866 -0.105481339254868 0.71985842848994 0.111405836889973 0.734770914728387 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EPB41L4B -0.14143421534503 0.847694356023549 0.950376610463724 -0.210036577802747 0.774001512159271 0.921709545085324 -0.988509308984089 0.0274929723905575 0.960057971217902 0.0215783929762419 -0.028451337766187 0.949455220911707 reversed False False False False False False False 0 insufficient_or_context_specific +LINC01554 -0.173660282004955 0.847737551390849 0.950376610463724 -0.412012773610092 0.641023956506104 0.864690294211249 0.644460134624791 0.258209419129536 2.0 False False False False False False False 0 insufficient_or_context_specific +MAP3K12 -0.0625007300301296 0.847885556240959 0.950376610463724 -0.105525036759743 0.74374421345279 0.909374800884141 0.477669099549865 1.0 0.241698663283507 0.582778628837223 -0.920047171844292 0.0208643764921566 -0.678348508560785 0.0878573955024189 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL356108.1 -0.0794790417524913 0.84788934201809 0.950376610463724 0.343573184614059 0.414473100037769 0.736663818217135 False False False False False False False 0 insufficient_or_context_specific +RGS2 0.100542653381041 0.847894252605511 0.950376610463724 -0.0107617219593982 0.984063145320636 0.99451887511202 0.484352805123165 0.401187707893867 2.0 1.27144723453718 0.115854092259814 -1.33671130032872 0.0430617546538406 -0.0652640657915366 0.949010089628798 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DPP10 0.079716630957033 0.847973104951489 0.950376610463724 0.155148494730402 0.713163354881427 0.895497343705388 True False False False False False False 0 insufficient_or_context_specific +ZFYVE16 -0.0270959937900987 0.848028303227988 0.950376610463724 -0.0492091811505126 0.727278588582887 0.903365569206837 0.134172384323697 0.782545460167395 -0.324508881822896 0.355113076188798 -0.190336497499199 0.641513223873496 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UCK2 0.0816351290642248 0.848029744949682 0.950376610463724 0.300952932971944 0.485154448564621 0.78154724869473 0.278141481184016 0.0342935288299199 2.0 -0.429069867025316 0.388302024083682 -0.410087344898421 0.336513023850605 -0.839157211923737 0.0769497813959028 partial_or_other True False False False False False False 0 cross_species_direction_conflict +VASH1 -0.053966967156527 0.848246830892429 0.950519002394637 0.178143318836509 0.536156042888667 0.811691353716453 0.5159957950442551 1.0 1.03588184926145 0.0846123041767393 -1.03624331503084 0.0415660410774832 -0.0003614657693959 0.999627531393661 reversed False False False False False False False 0 insufficient_or_context_specific +CD163 -0.137546991316017 0.848518065372425 0.950722034829891 -0.66523549344415 0.323702429642201 0.673694116333996 -0.100983996071498 0.901995164796902 0.0495673283334023 0.937182186482171 -0.0514166677380957 0.940961636105127 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYLK-AS1 0.0557376187830559 0.848673807899963 0.950795634954139 -0.0873754763818501 0.760876146666936 0.91579233430341 False False False False False False False 0 insufficient_or_context_specific +GID4 -0.0558698434409959 0.848914641756787 0.950813880764208 -0.0019232663732686 0.993907395818129 0.998542598236847 -0.678810189250049 0.0575428442719298 0.87433280062673 0.0111657045125426 0.195522611376681 0.541548967858627 reversed False False False False False False False 0 insufficient_or_context_specific +MPHOSPH10 -0.0413231305267316 0.849014210888431 0.950813880764208 -0.116271100522904 0.585432471037579 0.834931248036574 -0.119936935521953 0.780496639589111 -0.142980948940937 0.663162265868286 -0.26291788446289 0.441064885541466 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STK3 -0.027224266680722 0.849061780220569 0.950813880764208 0.136188686547765 0.325391227462274 0.674724889947951 0.0248878058027504 1.0 0.120972176538569 0.743854376911001 -0.682281110828431 0.0280852270411914 -0.561308934289862 0.0710172350507653 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF407 -0.0334166035484172 0.849284093168005 0.950813880764208 0.120847501742471 0.494656289633672 0.787126014461539 False False False False False False False 0 insufficient_or_context_specific +RPGRIP1L -0.0600490362982548 0.849295102421525 0.950813880764208 0.24079501468773 0.443090282254557 0.759069803674122 1.84434481271804 1.0 0.124659801458398 0.848480000850431 -0.830078250071014 0.0748078340314418 -0.705418448612616 0.174628306172717 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRD5A1 0.068678256971822 0.849541165169928 0.950813880764208 0.124832614761999 0.730997690402399 0.904431845923655 -1.0846181179352 0.0296420112408737 1.49006307574222 0.0048322254603935 0.405444957807026 0.333763018136185 reversed True False False False False False False 0 cross_species_direction_conflict +RAPGEF3 0.104495129184691 0.849588618774834 0.950813880764208 -0.396069452876925 0.449034433373115 0.763430845016642 -0.1831150994758 0.713504439354663 -0.370480978144367 0.33320990615613 -0.553596077620166 0.179972608686548 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AMMECR1 -0.0446568632538374 0.849590656481297 0.950813880764208 -0.120284909799751 0.603208036135115 0.845016786554015 0.266818796496894 0.651898598887457 -1.10164243066188 0.0302382813511962 -0.834823634164985 0.121418959981923 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFAND1 0.0553461953771183 0.849724893719474 0.950863320391118 0.35303090788693 0.237546790372509 0.605329180588419 -0.327491942500545 0.319222944547524 -0.420676480776757 0.142215759815676 -0.748168423277303 0.0278083645993672 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SOCS2 -0.0769844194953494 0.849972994264377 0.950894201796838 -0.489074503756184 0.19472182106161 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0.258858985064761 0.0103952844850845 0.970152811194507 -0.296124272574219 0.232855223024694 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF529-AS1 0.0515490190222112 0.850292873571126 0.950894201796838 0.248513389484098 0.368017175642349 0.708317354196916 True False False False False False False 0 insufficient_or_context_specific +TMEM87A 0.022299848878884 0.850576378185944 0.951110506342639 -0.0016556267684112 0.988786557690548 0.996718493722613 0.4894758756177779 1.0 -0.0437317724340963 0.906379486354135 -0.40434703996486 0.111623034729861 -0.448078812398956 0.102821576147703 partial_or_other False False False False False False False 0 insufficient_or_context_specific +B4GALT1 -0.0758128815914501 0.850952683192834 0.951371777402948 -0.553968484136279 0.164028925268065 0.544850245278 0.136577377056267 1.0 0.0469935753152732 0.908173535814737 -0.0187245918277481 0.952558027623544 0.0282689834875251 0.933570137924784 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP2 -0.0601827792394017 0.850990250596083 0.951371777402948 -0.329866660368011 0.290920038433034 0.650060056248883 0.7202045946756059 0.885437803338628 2.0 -0.322769631051937 0.532868572741029 -0.246478495703501 0.562115379051027 -0.569248126755437 0.207671459796773 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AKR1E2 0.061535021378236 0.851344196937229 0.951521031234105 0.155398310470197 0.63762268455639 0.862968889058629 True False False False False False False 0 insufficient_or_context_specific +HSF4 0.0963535423963136 0.85137151022311 0.951521031234105 -0.056940836782889 0.916092417069282 0.975207071931587 0.0227487188393294 1.0 -0.311678268798105 0.446282128096419 -0.658239475356042 0.068871070498288 -0.969917744154147 0.0230717935736413 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPAST -0.0306788042518427 0.851394125977324 0.951521031234105 0.145213101091482 0.387111691973398 0.720706267652113 0.1033860503523 0.756259296908965 -0.241687772935177 0.322735225741053 -0.138301722582877 0.619414042063371 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SECISBP2 0.031682059263912 0.852175274322334 0.951655796828666 -0.0359846928288991 0.832522318266823 0.944822630093409 0.839842665615937 1.0 -0.371073589819334 0.195270061745378 -0.418503853271938 0.10536014854617 -0.789577443091272 0.0137183103444898 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRFIP2 0.0394131216238833 0.852342713969734 0.951655796828666 -0.102406781737961 0.625859302874058 0.856624485564009 2.51253741926554 1.0 -0.263648559924628 0.20833541832002 -0.165231827451458 0.369926038555247 -0.428880387376086 0.0399511478509274 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ABTB1 0.0606101433360647 0.852425220959099 0.951655796828666 -0.228358220157744 0.469636981583434 0.773833242954571 0.202023485544395 0.500944444802863 2.0 0.0543951926945941 0.897001621602797 -0.0027561592456541 0.994301821533711 0.05163903344894 0.884330900949653 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PXDNL 0.0522996786548885 0.852571177281119 0.951655796828666 0.466204903660817 0.099809836955478 0.478125555523304 True False False False False False False 0 insufficient_or_context_specific +AC007563.2 0.0729760389600316 0.852729990972141 0.951655796828666 -0.41223254614122 0.277513223954639 0.64071639456045 False False False False False False False 0 insufficient_or_context_specific +TYW1B -0.0315958094271411 0.852746348697521 0.951655796828666 0.0954286076111388 0.571805554747021 0.827343161164732 False False False False False False False 0 insufficient_or_context_specific +MECP2 0.0275968368104724 0.8531082567114 0.951655796828666 0.0610394499390101 0.68149915575261 0.881539414637616 0.308374681962969 1.0 -0.154853009874523 0.701284020990754 0.311760731020585 0.306922490386723 0.156907721146063 0.653185244557892 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZYX -0.0662607674301395 0.853279462489811 0.951655796828666 -0.288303948677351 0.418649781041415 0.740385994679274 0.096060453785672 0.812410751771662 0.243480458039065 0.402478899191628 0.339540911824737 0.267066488671637 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TAT-AS1 -0.186277056349576 0.853388454828125 0.951655796828666 -0.176552169206998 0.861323740009431 0.957752084994162 0.5366362551241161 1.0 False False False False False False False 0 insufficient_or_context_specific +GOLPH3L 0.0529956395844017 0.85347823773753 0.951655796828666 -0.026146031047522 0.927353528466083 0.979087152943213 -0.050134667060487 0.907216360066205 0.303105128330205 0.267002394033964 0.252970461269718 0.404145260362165 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CUL2 -0.0375740909214954 0.853587225098417 0.951655796828666 0.0114864725420829 0.955059917966589 0.987410276805219 0.674115756397002 1.0 -0.387338143912575 0.182560032256214 0.534924391158941 0.042607068973426 0.147586247246366 0.591123721088833 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PFKFB3 -0.0467099882956515 0.853698198514649 0.951655796828666 -0.129791754944104 0.608525887414442 0.847936692532885 0.291388160156932 1.0 -0.671497366060183 0.142940613664619 0.299947335872011 0.455197813416598 -0.371550030188172 0.375922234674249 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC093668.2 0.0649378125629225 0.853768110206585 0.951655796828666 -0.333146377551358 0.319581549659194 0.672139840896768 False False False False False False False 0 insufficient_or_context_specific +HERC1 -0.0290872084083367 0.854208256223678 0.952045895620141 -0.0446793976418425 0.777842282759182 0.922929913000972 0.0660539616808821 0.832139711857781 -0.335177366974036 0.1339168809471 -0.269123405293153 0.24961937906111 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCYL2 -0.0327475857680621 0.854495077440004 0.952187817249444 0.0630950259227857 0.726373040670035 0.903365569206837 0.45044930498112 0.166068813766625 -0.279440868975202 0.304219601056168 0.171008436005918 0.589535480158036 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC9A6 0.0569039248755171 0.854515965944164 0.952187817249444 0.323957237692265 0.281662517925506 0.64315368591277 1.30626922773537 1.0 -0.277765574398247 0.491060251943551 0.339003889000471 0.279411316174752 0.0612383146022231 0.879183211907941 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SGSM1 -0.0710846874228561 0.854656598534071 0.952244023567193 -0.0571794346690471 0.883101731987678 0.962803395944434 0.268763171444263 1.0 False False False False False False False 0 insufficient_or_context_specific +PNKP 0.0502849942322801 0.854953187143891 0.952473963265295 -0.114048214086168 0.687672939699249 0.884451344908836 0.5790419376790269 0.6428223672342429 2.0 -0.107297494493788 0.801445920945642 -0.0808694589972292 0.807603598431137 -0.188166953491017 0.582242606391758 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IGF2R -0.028938566393919 0.855320889830527 0.952682556686434 0.0792624479140798 0.607202417145185 0.846972709287018 0.25421741243182 0.37679897285318 0.0723203604173175 0.773902352418851 0.326537772849138 0.204637880572879 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACTR10 -0.0328168485778216 0.855509053189667 0.952791622740138 -0.0762676226108068 0.666710248410297 0.875295548708768 0.122919246862637 0.687382941697794 0.269707703985689 0.233046871575111 0.392626950848326 0.11862704055991 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SGSM3 -0.0903255445687578 0.855767440346747 0.952977091873544 0.295921760508136 0.570026400856031 0.826127486649001 0.551957786245115 0.0157707053914115 2.0 0.112007574500957 0.784947378045873 -0.60359631638824 0.0553744195062967 -0.491588741887283 0.141482663882024 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARID3B -0.0803130469779523 0.855960369414689 0.952977091873544 -0.525329336185237 0.207176772176277 0.580154953582323 0.4233355788027001 1.0 -0.139979502668749 0.78897181771744 -0.418919435543517 0.271012402323305 -0.558898938212266 0.183128207011902 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FLNA 0.060641598379767 0.856113062438742 0.952977091873544 -0.176283715932521 0.598377934874379 0.842680747516785 0.31073763464453 1.0 0.841343592788341 0.0382757462821866 -0.956759222481065 0.0166167738957158 -0.115415629692724 0.773992188706357 reversed False False False False False False False 0 insufficient_or_context_specific +ICA1 -0.0808591212390202 0.85614320840701 0.952977091873544 -0.150053343490485 0.734993783997491 0.905163185228954 -0.617006954696656 0.216729991551008 -0.0635994949726788 0.901235381765542 -0.680606449669335 0.14468654515616 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM173B -0.0457549070755604 0.856147331328786 0.952977091873544 0.0006551939904016 0.997187326373025 0.998795540446485 False False False False False False False 0 insufficient_or_context_specific +NT5C2 -0.0256045329263934 0.856253198508679 0.952977091873544 -0.0451869116735919 0.749285884186039 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1.0 False False False False False False False 0 insufficient_or_context_specific +PRELID3A 0.0705418306785277 0.856923405623071 0.953243404596172 0.197367792922944 0.614844233357241 0.851310824631544 True False False False False False False 0 insufficient_or_context_specific +SPRY4 0.0683348909059029 0.857116066279682 0.953243404596172 -0.0908365919467713 0.811659912003205 0.933904244870297 0.48053737850084 0.0695481254252191 -0.207377639151743 0.349147292687215 0.273159739349097 0.263463688484328 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC003102.1 -0.0635279762845709 0.857242967712133 0.953243404596172 -0.0975080858753646 0.781392977626662 0.924363815998016 False False False False False False False 0 insufficient_or_context_specific +AGTPBP1 -0.0341383374104099 0.857356834795777 0.953243404596172 0.137949395866786 0.482028670913123 0.780666906162311 0.17548006299993 0.535995702919219 -0.77406927288002 0.0069050590607853 -0.59858920988009 0.0298131918658172 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZMYM1 0.0310487882804044 0.857359288695325 0.953243404596172 -0.15715280465072 0.357817875999435 0.701288497271586 0.32247538942346 0.54781422572657 -0.513967470534208 0.210298681032168 -0.191492081110749 0.711253087720312 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZBTB34 -0.0756297334167006 0.858086945312962 0.953751128393963 -0.0771538297596816 0.855454886708708 0.955654713138349 0.285103710709352 1.0 0.131653899329765 0.727576365037144 -0.157767095317449 0.584899240463457 -0.026113195987684 0.94192263216745 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYB5R4 -0.0385482138325264 0.858229690345355 0.953809375859606 -0.0970193150844931 0.653689432711515 0.870639750062571 0.113616266714635 0.823089245459464 -0.118627874379288 0.753618139547397 -0.0050116076646525 0.99170857909218 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPL3 -0.0608005146192344 0.859014226003631 0.954331445747316 -0.280915877840213 0.386352694150206 0.720477739899883 0.9457024163503671 0.488665478934723 2.0 False False False False False False False 0 insufficient_or_context_specific +NUP93 -0.0435406177752017 0.859044174870483 0.954331445747316 -0.0482212030257338 0.844160756808262 0.950868579539813 0.0880204428680539 0.863241109047501 -0.325662325468508 0.340728898528871 -0.237641882600454 0.552551034338873 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ECPAS 0.0254732891402915 0.859053098588414 0.954331445747316 0.228449059944411 0.113893290746414 0.4924007041452 0.0902243444388557 1.0 -0.181936404819459 0.528973311112804 -0.0063101935761334 0.982326201083543 -0.188246598395593 0.45426602617902 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SAMD9L -0.0630780785267909 0.85916461727275 0.954331445747316 -0.170748029235099 0.629116102506307 0.85847330518205 -0.0027795465679542 0.996617940730295 0.326012770072593 0.366286807991205 0.323233223504639 0.425570285641061 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMOD2 0.054070013416025 0.85920550460085 0.954331445747316 0.15253081785286 0.622678353109991 0.855079408706246 True False False False False False False 0 insufficient_or_context_specific +HEBP1 -0.0521702768071535 0.859474270297523 0.954389093175857 0.000904769524059 0.997382436288412 0.998801457112118 -0.970547792632555 0.0246758315508145 1.22171367781224 0.0067714616839633 0.251165885179687 0.513570198926858 reversed False False False False False False False 0 insufficient_or_context_specific +MAN2B2 -0.0438989266466004 0.859474474134878 0.954389093175857 -0.355344023632732 0.141786079637192 0.526995437876627 0.0140248389734241 0.967348503113051 0.259492814907811 0.260126911225266 0.273517653881235 0.2654898395993 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRGAP2B 0.035748863012435 0.859781452212337 0.954454647801799 0.284232339243063 0.154971004200081 0.539282749619134 True False False False False False False 0 insufficient_or_context_specific +AC026471.4 -0.0481861506068752 0.859804712563261 0.954454647801799 -0.128975693920696 0.637979794293887 0.863120280388885 False False False False False False False 0 insufficient_or_context_specific +ZNF394 -0.0348609465753766 0.85997967843527 0.954528552016571 -0.203605486607748 0.282898348944884 0.643993266097475 False False False False False False False 0 insufficient_or_context_specific +NOL8 -0.0248102166119037 0.860052104123285 0.954528552016571 0.114824033941714 0.433572255573836 0.751660242498796 0.3577142876015271 1.0 0.35885563773462 0.367737903816297 -0.0959932238343089 0.779636844296658 0.262862413900311 0.472320343024731 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLEKHA5 -0.0393312930058195 0.860276255721433 0.954676971610983 0.0067914586017856 0.975761641103426 0.992949014430083 0.0470814885943791 0.867343742797072 -0.677696742802509 0.0060810720550719 -0.63061525420813 0.0127367259390582 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BMS1 -0.0394846470890373 0.860450807743572 0.954692262146729 -0.0170144641497074 0.93984621619639 0.983658266508924 -0.144947438183188 0.685214634579747 -0.138764861726142 0.622500183289973 -0.28371229990933 0.334674444347233 partial_or_other False False False False False False False 0 insufficient_or_context_specific +VEGFB 0.0574212216338872 0.860615797736473 0.954692262146729 0.154494607869326 0.639617686338937 0.864573988534439 0.493461472620381 1.0 -0.0598409580340712 0.888962750799615 0.0619468633277963 0.849564180264112 0.0021059052937251 0.996208913330024 partial_or_other True False False False False False False 0 cross_species_direction_conflict +KLHL25 -0.0706567291542556 0.860693373288103 0.954692262146729 -0.253917142173503 0.526509935158839 0.804819865166353 0.302291760525448 0.282111581979009 0.0498817191538282 3.0 -0.177280927540286 0.68614406247997 0.0985240346318153 0.778847583482528 -0.0787568929084706 0.846072794634436 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SOCS7 -0.032142218835418 0.860942106541925 0.954692262146729 -0.0095443163812659 0.958529185420327 0.988199505875189 0.5489858603351571 0.325637496445665 2.0 0.0894249019586367 0.891610561268189 0.0702681931027567 0.883708176953033 0.159693095061393 0.760710459018827 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SCO1 -0.0446936733438934 0.861122636124525 0.954692262146729 0.154089870580084 0.551402291387108 0.817770107102835 -0.0917834846769575 0.862969457241543 -0.0274444285681324 0.946760504863134 -0.11922791324509 0.785305333942324 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CWF19L2 -0.0272421160966881 0.861217194022161 0.954692262146729 -0.101237719058411 0.51111734493126 0.796519013040946 -0.102417646844961 0.761286518663403 -0.465873261209164 0.0762829012171142 -0.568290908054124 0.0473736748509004 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM160A2 -0.040270165869836 0.861263026066255 0.954692262146729 0.14291794195037 0.529459266085746 0.806642270033665 0.0244304331573192 1.0 -0.179085929262451 0.531342754872783 -0.383782112697282 0.106104090122557 -0.562868041959733 0.0372249485721229 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GATAD2B -0.0224786387391184 0.861284693781739 0.954692262146729 -0.0582095096863389 0.644311548241267 0.866251949351307 0.136944376307194 0.387274244937867 2.0 0.0277815265822238 0.940685645135291 0.0858535857009546 0.746711467176359 0.113635112283178 0.690966927558612 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INTS10 -0.0248150427655094 0.86148613572391 0.954811956884492 0.0617257076557715 0.659463698126843 0.872180599376577 0.400564938694492 0.176969671074957 -0.110244305250428 0.66567812259354 0.290320633444064 0.291542876548245 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAB33B 0.0618016429500651 0.861846462988437 0.954811956884492 -0.347855028210629 0.31911694392299 0.671430190103413 0.0110793378506799 1.0 -0.0065526966493316 0.987274567026432 -0.319396467325084 0.223303275223859 -0.325949163974416 0.253728124196861 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DAAM2 -0.06062761989021 0.861910186003366 0.954811956884492 -0.0687532546056898 0.843592827926402 0.9506514118099 0.8133343750370621 0.433113687738809 2.0 0.36865876728785 0.353814130855971 -0.0109404076010897 0.978321864408441 0.357718359686761 0.319194466427974 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TARBP1 -0.0597257938455804 0.861919660889481 0.954811956884492 0.0267365883831861 0.937581022846215 0.982821727483155 0.535988313896385 1.0 0.433762418690366 0.288690537886742 -0.479941318332062 0.154118287031607 -0.0461788996416956 0.918668373739419 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP006621.3 -0.0653597869758881 0.862024713405051 0.954811956884492 -0.250114893007362 0.49604718450809 0.78815141821466 False False False False False False False 0 insufficient_or_context_specific +NUS1 -0.0378891768451279 0.862175632563462 0.954811956884492 0.0860605006270953 0.697568229385219 0.88884814126198 -0.0563015436668514 0.874007337246099 -0.238863640238736 0.335957721539466 -0.295165183905588 0.25988448248272 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CFL2 -0.0565625041094476 0.862190165851019 0.954811956884492 0.172908270746186 0.595804450415561 0.840863973731786 0.312934460093689 1.0 0.159084843277243 0.538021773301436 0.0081158417801333 0.973317763671041 0.167200685057376 0.456342821466359 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ELF1 -0.0344759828431644 0.862282428760798 0.954811956884492 0.0750506560726739 0.704561379519544 0.89229234871308 0.103621717241783 1.0 -0.0391844088195325 0.917383338862434 -0.13177058288521 0.606513121661291 -0.170954991704743 0.536884448224877 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC098617.1 0.0719907785248606 0.862297026794244 0.954811956884492 0.394022101245617 0.345982239649603 0.691178899947117 True False False False False False False 0 insufficient_or_context_specific +SCNN1A 0.0834823226970951 0.862653279131805 0.954916504314124 -0.0386104432004841 0.940807882515012 0.984054846799435 -1.28335319203601 0.0075242631258834 0.992504457447492 0.0173455152623454 -0.290848734588518 0.436468573389136 reversed False False False False False False False 0 insufficient_or_context_specific +IL1R1 -0.0502137795563885 0.862741132456714 0.954916504314124 0.0401629259563802 0.88967702729252 0.964593351217337 0.217147395843192 0.273333688540234 2.0 0.231275337645353 0.395635024105465 -0.28564703283935 0.217529165562804 -0.0543716951939965 0.844293963005993 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDFY1 0.0372279180304798 0.863190942634499 0.955141241949026 0.17951020845627 0.392852695970987 0.725129154556239 0.299420017056037 1.0 -0.269919024495215 0.440619610306709 -1.00764999308445 0.0069159923525571 -1.27756901757967 0.0038808768496921 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TNFRSF21 -0.0786694872608222 0.863192249453762 0.955141241949026 0.388203062393266 0.407009824745787 0.733976772200131 0.31478571072993 0.471119257261521 -0.207368717820551 0.578374190424788 0.107416992909379 0.800798170345124 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ENC1 -0.0867465076888104 0.863280463507968 0.955141241949026 -0.0169872056564102 0.973174265525244 0.99234826109866 0.7474186077599959 1.0 2.43437627821373 0.0007832524455666 -1.56493087938327 0.004207642844782 0.86944539883046 0.109410042681297 reversed False False False False False False False 0 insufficient_or_context_specific +NLGN4X -0.0618018704664824 0.863355933586012 0.955141241949026 -0.45852876900225 0.188264275752963 0.56929178900529 False False False False False False False 0 insufficient_or_context_specific +NOTCH4 -0.115935187667411 0.863478179720442 0.955141241949026 -0.712766096322531 0.25416514481168 0.619121653608424 False False False False False False False 0 insufficient_or_context_specific +AC005884.1 0.0779430487876692 0.863586887352441 0.955141241949026 0.0910153458870305 0.841256367545989 0.949538671001769 True False False False False False False 0 insufficient_or_context_specific +ZFP36L2 0.0749422880191172 0.863890255489726 0.955141241949026 -0.0334419060732858 0.939030746371054 0.983643567603279 0.372950536936519 0.347467498547746 0.0709287829433618 3.0 -0.455433100454876 0.31738191177615 0.0566850918014266 0.902660460420492 -0.398748008653449 0.334316328011206 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NUP155 -0.0276155961933498 0.863901985485321 0.955141241949026 -0.067385359286262 0.673114232896016 0.87748364871171 0.307672672724343 0.343732521035371 -0.295855104951078 0.271384794935438 0.0118175677732656 0.974165225485231 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRKAG1 -0.0376016420783361 0.864078146297635 0.955141241949026 -0.118888215782049 0.586243905654235 0.835145405883496 0.104517925260615 0.763095593688606 -0.187553179385707 0.46283250133801 -0.0830352541250922 0.785600176595222 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC191 -0.0403200870864803 0.864110416515126 0.955141241949026 -0.0779533451389023 0.741045131501276 0.908406208990048 -0.204743702794805 0.654517229203276 -0.571578488258904 0.117566093646089 -0.776322191053709 0.0593069137568626 partial_or_other False False False False False False False 0 insufficient_or_context_specific +REXO2 0.0501022033112297 0.864128495962953 0.955141241949026 -0.129940362957669 0.647000170179759 0.868438643927354 -0.189423604096341 0.511076759321084 -0.213491610531864 0.372276454994945 -0.402915214628204 0.113009834193068 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBM17 -0.0355527458117193 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+MTERF2 0.0450316065571291 0.864984067483511 0.955676560301004 -0.140854955920017 0.599939796003704 0.843257280459236 0.540363239214825 0.556785375376211 0.368625198202933 0.541412917233681 0.908988437417758 0.229264102200865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NCAPD2 0.0470719207024226 0.865198468443767 0.955719337709697 -0.357216905612774 0.184488016914148 0.566392696301126 1.7294385351465 0.0050289570433322 -1.65278889647305 0.0038960801203268 0.076649638673446 0.905903214090264 reversed False False False False False False False 0 insufficient_or_context_specific +USP48 0.0248934503637654 0.865385701109122 0.955826156743395 0.0865215801734091 0.552883867952321 0.819071644755648 0.49668192603282 1.0 -0.025459425655258 0.938610983807192 -0.181609171412059 0.41580324185891 -0.207068597067317 0.381203194716467 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CDK6 -0.0511697966263633 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-0.0763077823559778 0.870463479751302 0.957923448188657 0.338522776563032 0.456111968335283 0.767060408474954 0.551922754548751 1.0 False False False False False False False 0 insufficient_or_context_specific +WDSUB1 -0.0325875862967291 0.870694224972857 0.957923448188657 0.0234176362735597 0.907431639251709 0.971275673886815 0.261267735793934 0.599670723393398 -0.151744894291023 0.701877835664097 0.109522841502911 0.818383183959771 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TAPT1-AS1 0.0320189354899073 0.870813565198647 0.957923448188657 -0.169712229893516 0.388520742863138 0.72189097377384 0.000143174221413411 1.0 False False False False False False False 0 insufficient_or_context_specific +SYNPO -0.0454748467131229 0.87098097713782 0.957923448188657 0.180177646281343 0.519186234560285 0.801047042355318 0.37545288283691 2.0327675024748 2.0 0.860646078427267 0.0140974727571005 -0.660871989126104 0.0318907698878728 0.199774089301163 0.517994422801763 reversed False False False False False False False 0 insufficient_or_context_specific +HOMER1 -0.0643472230687235 0.871191256177131 0.957923448188657 -0.001593626257328 0.997480294909195 0.998804718669507 0.33358601464739 1.0 0.0691600332651759 0.911205409548353 0.115075364271217 0.785854455944186 0.184235397536393 0.696137894766071 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC006299.1 -0.0563651184092059 0.871287171110875 0.957923448188657 -0.265999757731916 0.436028373682855 0.753451320678163 False False False False False False False 0 insufficient_or_context_specific +CCNK -0.0312088451097501 0.871350765950219 0.957923448188657 0.0009612281979682 0.995607144582496 0.998795540446485 0.0608191723086967 0.876566872609043 -0.0988589210811286 0.726458885914625 -0.0380397487724319 0.911441788670867 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RHOBTB1 -0.051050427310744 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False 0 insufficient_or_context_specific +PLCL2 -0.0302023245770263 0.871608497048427 0.957923448188657 0.0337938246567029 0.857261434728675 0.956914759994669 0.259963907104512 0.403732892501058 -0.133697908624707 0.616789265038313 0.126265998479805 0.67258129263617 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYO5C -0.0744539499165345 0.871636424236217 0.957923448188657 -0.270842429267752 0.5429553682316 0.814401918734668 False False False False False False False 0 insufficient_or_context_specific +NF1 0.0255579610591599 0.871649747724378 0.957923448188657 0.100088278707187 0.519268903748884 0.801047042355318 1.42046422144057 1.0 -0.0474753168618952 0.885896209712577 0.112738063766962 0.628637367745842 0.0652627469050665 0.808357610526879 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WBP11 0.0328797582693699 0.872148695430841 0.957923448188657 0.0968219989055566 0.63429260837999 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0.957923448188657 0.0036026757448812 0.992492519641501 0.998236115892821 False False False False False False False 0 insufficient_or_context_specific +ZBTB24 0.0529900855189004 0.8728074081746 0.957923448188657 0.329249873092608 0.331615935624185 0.680373309040058 -0.166172301470674 0.625942919662045 0.123047182623356 0.654864191383313 -0.0431251188473189 0.89706283302159 partial_or_other True False False False False False False 0 cross_species_direction_conflict +F9 0.0708864278615411 0.872884016252419 0.957923448188657 0.226168621808094 0.609526169638101 0.848013066172034 -0.969782719541884 0.0327281775735522 1.47893568686488 0.0036199308574951 0.509152967322999 0.192899245795642 reversed True False False False False False False 0 cross_species_direction_conflict +SERINC2 -0.0768449892292032 0.872951065858641 0.957923448188657 -0.110710863037645 0.816608119143875 0.936230700610385 -0.841006743320713 0.10330193249397 0.0496793598034282 0.925600065404511 -0.791327383517285 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partial_or_other False False False False False False False 0 insufficient_or_context_specific +PAPSS1 0.0416170120531354 0.87346020956545 0.95793008129137 -0.0281749925151448 0.914333233958316 0.974218415998779 -0.160743267839289 0.583165332079096 -0.152455718847871 0.520179627167617 -0.313198986687159 0.209151574780645 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBCB 0.0375851052370084 0.874026437040246 0.958090989658266 0.126033468989037 0.602670937644908 0.844795507123598 0.338756650018342 1.0 -0.102943592838577 0.79521665489501 0.586235045604408 0.0494221180531158 0.483291452765832 0.114433402595348 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CFAP221 0.109055331858499 0.874042227646432 0.958090989658266 -0.393599044965589 0.552742477572644 0.819071644755648 False False False False False False False 0 insufficient_or_context_specific +LCORL 0.0296693825805257 0.874063343567693 0.958090989658266 0.151059370698131 0.411337959064341 0.735291083225579 -0.0903837775896751 0.859070568791721 -0.627251477977247 0.0872598273113015 -0.717635255566922 0.073908049142282 partial_or_other True False False False False False False 0 cross_species_direction_conflict +C19ORF70 0.0522023507675075 0.874151402100594 0.958090989658266 0.188976852275829 0.56978065450109 0.825998098341687 True False False False False False False 0 insufficient_or_context_specific +PTCD3 0.021634390184835 0.874324161702296 0.958180869758443 -0.0779355812424021 0.575665167070591 0.829928048970172 0.0954574392792991 0.751798143959638 -0.195170833397089 0.38437743527353 -0.0997133941177895 0.700269329176676 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIGA1 -0.0248889533970145 0.874437956608782 0.958206117890557 -0.002896108632488 0.985285015893477 0.995307821007743 0.100374810356336 1.0 -0.416325323914559 0.310442499266324 -1.03816895651528 0.0154742191171605 -1.45449428042984 0.0055519882210824 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CASP3 0.0351247371193507 0.874953045827829 0.958511737268424 0.0663531866294094 0.766597259959608 0.919349911228398 -0.207338531728727 0.698349579668637 -0.204798316613204 0.626382705106563 -0.412136848341931 0.35132883408202 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EXTL2 -0.0366013633294581 0.874986074858287 0.958511737268424 -0.0745590264646376 0.746548194772729 0.909830759894547 0.293297446425396 1.0 0.251028398776556 0.639010697485095 0.430035635719953 0.250909415353925 0.681064034496509 0.121909348496339 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RTTN -0.0426803166375363 0.875079999576657 0.958511737268424 -0.249938233834266 0.360720831431821 0.703177809506737 -0.303360480485949 0.603058723071737 0.0388932286425499 0.940468359110591 -0.264467251843399 0.608119365637099 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRKRIP1 -0.0223097886808155 0.875322201143422 0.958677572580109 -0.054447603851809 0.700229148673703 0.890296164703391 0.072461296292972 1.0 -0.0774554291831957 0.866469274413457 -0.600616898216706 0.0703518890503919 -0.678072327399902 0.0651145294621365 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC005261.1 -0.0271857374649159 0.87554803915164 0.958825453517582 -0.121291647036546 0.493009770805501 0.786363265568912 False False False False False False False 0 insufficient_or_context_specific +HNRNPD 0.0212428393696429 0.875736278335236 0.958929339185136 -0.0599333388410945 0.660162411037126 0.872407073022888 0.251671474150134 1.0 0.101128363349753 0.749355394229607 -0.59157267170357 0.02507828568929 -0.490444308353817 0.0651599735844537 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NBPF19 0.0319871371502887 0.875915376690799 0.958929339185136 -0.0300842023926712 0.880702611395457 0.96227446663699 False False False False False False False 0 insufficient_or_context_specific +EGFL7 -0.0835158091835484 0.87625043762887 0.958992930612751 -0.112266988077766 0.833805196397852 0.945677866964069 0.539047667444383 0.0607211806197977 -0.550445919767037 0.039110718478162 -0.0113982523226532 0.971821319506505 reversed False False False False False False False 0 insufficient_or_context_specific +VNN1 -0.079042601224335 0.876252589426241 0.958992930612751 -0.220708445790949 0.658105654766699 0.871691185476023 -0.457306105055131 0.60204731487142 1.41561841423402 0.0320742930120582 0.958312309178886 0.151751281577038 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CEP164 -0.0345448766475366 0.876336786754293 0.958992930612751 -0.138738974604337 0.521803576411453 0.802314792678957 0.0847780386219344 0.804032337519496 -0.801244320757346 0.0080477022420879 -0.716466282135412 0.0205683374149157 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM149A 0.050166050398119 0.876685634175971 0.959275253977604 -0.280997770921605 0.382202959978038 0.718152491804259 -0.254645677621457 0.620919453381129 0.122369760798926 0.774791882855681 -0.132275916822531 0.781225184787245 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RASSF3 0.0358187972671964 0.876875809400571 0.959296127221015 0.19850746248501 0.389522514596232 0.722218665388488 0.011423394265179 1.0 -0.52418062738903 0.132939587622644 0.236676264766519 0.435882593729777 -0.28750436262251 0.368870275688209 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TMEM11 -0.0729548630534683 0.876938268372202 0.959296127221015 -0.244768590952536 0.584283117084929 0.83427397074951 -0.3884678989934 0.229842501577756 0.390000366382212 0.157229114637285 0.0015324673888123 0.996903220681512 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1ORF21 0.0370716329437936 0.877162426467463 0.959296127221015 0.120708334929033 0.620678913638112 0.854161622809071 1.05252644893539 0.333844390818966 2.0 True False False False False False False 0 insufficient_or_context_specific +SERGEF -0.0306112361179804 0.877251771364179 0.959296127221015 0.114065470124759 0.564240210851702 0.823754286312897 0.208182151241703 0.617704561534471 -0.632299863649826 0.0611054937429738 -0.424117712408123 0.245275409067308 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TSPAN18 0.0741063846268662 0.877310373303049 0.959296127221015 -0.0330085706076086 0.945515402259583 0.985432868134933 1.20505864425857 1.0 0.588225697649853 0.552892169078678 0.393684514287917 0.549220727011937 0.98191021193777 0.227440642102848 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IQCN -0.131091515096059 0.877467879349223 0.959309735643114 -1.98706666576124 0.0104979308123175 0.302245517751671 False False False False False False False 0 insufficient_or_context_specific +ARF1 0.0272338791731041 0.877534895514415 0.959309735643114 -0.0310735405527024 0.858668564678835 0.956914759994669 0.313102744086027 0.362602826366895 0.149675704731927 0.620971800241811 0.462778448817955 0.139140398896498 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NEK11 -0.0551268684078375 0.87797031051271 0.959668908399329 0.0712036953754643 0.842477301080396 0.950469545398617 False False False False False False False 0 insufficient_or_context_specific +AL035413.1 0.042506801043021 0.878109393939202 0.959668908399329 -0.153115136760427 0.576777518333204 0.83036368131276 False False False False False False False 0 insufficient_or_context_specific +MPPE1 -0.0430849755284809 0.87825467885145 0.959699120193915 -0.170823573664663 0.542838690069126 0.814401918734668 0.258356239609847 0.495330805341603 -0.334812962233082 0.259691242281437 -0.0764567226232354 0.841465089377446 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BCLAF1 -0.0232943917765173 0.878784168832855 0.960178335355198 -0.0144037909055586 0.92491341236082 0.978480541854262 0.466925907382246 1.0 0.063562452484937 0.83920342428609 -0.413615795149261 0.0729066936551299 -0.350053342664324 0.138649477482522 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MMP16 0.0689065496758484 0.878899808054243 0.960196755779796 0.413535818077835 0.361430665766335 0.703277731139138 0.807963048070433 1.0 True False False False False False False 0 insufficient_or_context_specific +MCPH1-AS1 0.0559804921178844 0.879058599754131 0.960196755779796 0.513579391470505 0.173610466458057 0.55532911153872 True False False False False False False 0 insufficient_or_context_specific +MCEE -0.0358156021283951 0.87913932848752 0.960196755779796 0.229960616021808 0.335407858495695 0.684461073909613 0.034945061238063 1.0 -0.155520125180404 0.717155266108464 0.660709281858998 0.0483478835564302 0.505189156678593 0.141391011251308 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF684 0.0458015863009562 0.879164807550984 0.960196755779796 0.104641115258877 0.73083926323698 0.904431845923655 True False False False False False False 0 insufficient_or_context_specific +NR4A2 0.0725044852758862 0.87937065131296 0.960234398383731 -0.392747677320042 0.398045544980933 0.728473715359454 1.00889730258164 1.0 False False False False False False False 0 insufficient_or_context_specific +PPP3CA -0.03446192331501 0.879579788414842 0.960234398383731 0.178543575626066 0.428101012025942 0.74799415349718 -0.396918732078941 0.123436358595176 0.0226655049555861 0.931269636795672 -0.374253227123355 0.120165656424058 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRPC5 -0.114885111099015 0.879680350015378 0.960234398383731 -0.374011751403892 0.603057894459476 0.845016786554015 False False False False False False False 0 insufficient_or_context_specific +FOPNL -0.0413138160647832 0.879744964535502 0.960234398383731 -0.11163158827023 0.678841763293086 0.880276509070057 0.34028506905982 0.396310121052785 -0.402087784731995 0.217082322438899 -0.0618027156721752 0.885110769939715 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPL20 -0.0410800108200124 0.880251187766529 0.960383728795751 -0.209490797414124 0.42709521065921 0.747434316946782 False False False False False False False 0 insufficient_or_context_specific +AL583836.1 0.11027814960795 0.880460721832455 0.960383728795751 -0.0246305676400993 0.973369663644717 0.992355823557447 False False False False False False False 0 insufficient_or_context_specific +DNAJC1 -0.0291998927766641 0.880584992016503 0.960383728795751 0.191494293066271 0.314772338051559 0.667014790741693 0.0780310679866835 0.816326782498487 -0.402704393384714 0.100149256514641 -0.32467332539803 0.209384326395718 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARIH1 -0.0189778345538355 0.880624551097275 0.960383728795751 -0.002840608638503 0.981916981900766 0.99451887511202 0.3203997372245119 1.0 -0.0571302825217838 0.842120288450274 -0.34041735328941 0.100124132024495 -0.397547635811193 0.0739110488639748 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS18B -0.0523388206931375 0.880785641772725 0.960383728795751 -0.258751860391323 0.4380557319333 0.754854319855032 False False False False False False False 0 insufficient_or_context_specific +YWHAG 0.0424753619161968 0.880843060291428 0.960383728795751 0.107196318719587 0.705079838606063 0.892486864405085 0.373596163549974 0.271767477527551 2.0 -0.106234305369768 0.75658719898162 -0.129192774767618 0.63061272584804 -0.235427080137386 0.385423460592657 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC060809.1 0.0616460266183008 0.880866335379817 0.960383728795751 0.0699232058971872 0.865437051625159 0.958391272020028 0.0487048778348832 1.0 True False False False False False False 0 insufficient_or_context_specific +CHPF2 -0.0463763217630489 0.880980752943198 0.960383728795751 -0.0813595590212412 0.790350975152143 0.927375594093834 -0.0436308259814129 0.919627505193177 -0.348215129580684 0.234974067166521 -0.391845955562097 0.206648669524139 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC009264.1 0.0958048912850504 0.881064292206445 0.960383728795751 -0.110254423111444 0.858359192116339 0.956914759994669 False False False False False False False 0 insufficient_or_context_specific +USP9Y 0.155204594336617 0.881296568324432 0.960537748360623 -0.44874888975019 0.664458737071057 0.874623531479394 False False False False False False False 0 insufficient_or_context_specific +ENTPD7 -0.0545522720359813 0.881393456794335 0.960544190424709 -0.0969856868701582 0.787929696297723 0.926576536501901 0.450140567816809 0.253478310112598 -0.668552972978845 0.0577080394056011 -0.218412405162036 0.572254108811298 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RIMKLB 0.0238872597237215 0.882148925094919 0.96116907648629 -0.0619759522564965 0.697363889042455 0.888803059281445 False False False False False False False 0 insufficient_or_context_specific +LINC00342 0.0416928085016984 0.88262577149997 0.961436100435235 -0.104556216429869 0.70844392575975 0.893638108503159 False False False False False False False 0 insufficient_or_context_specific +PGM5 0.0652032730046024 0.882667183322479 0.961436100435235 0.231754821231787 0.6058446530228 0.846820726734085 True False False False False False False 0 insufficient_or_context_specific +DCUN1D4 0.0329310736809537 0.882945345619049 0.961558104600742 0.179013786841727 0.406466736825366 0.733961461951707 -0.307866567019036 0.278219007553227 0.398064420318806 0.10257906005202 0.0901978532997696 0.747478840305635 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TJP1 -0.0226515031273346 0.883072777275117 0.961558104600742 0.100632312813294 0.502902618906128 0.79229878349175 0.307086445234373 1.0 -0.0503177412402923 0.870171273921692 0.141391936573451 0.509079009685812 0.091074195333159 0.709907780430773 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OGFRL1 -0.0473517445481137 0.883211426805596 0.961558104600742 -0.193006610304122 0.550366410698634 0.817186218568941 0.263000925449606 1.0 -0.787690049955564 0.0638239665500192 0.613112864242812 0.0905458158391764 -0.174577185712752 0.659788869519024 reversed False False False False False False False 0 insufficient_or_context_specific +SLC39A11 0.0236436529259231 0.883246980736644 0.961558104600742 -0.169792071526735 0.25895307924321 0.622885940784012 -0.0386694367261807 0.922324480025494 -0.539454097127432 0.0555251282111667 -0.578123533853613 0.0553717862347803 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF596 0.0421526091759347 0.883325635207672 0.961558104600742 -0.191873987894905 0.493573434189551 0.786363265568912 False False False False False False False 0 insufficient_or_context_specific +DDX3Y -0.144581334685041 0.883569126906794 0.961650839265131 -0.796126742798196 0.414521665469596 0.736663818217135 -0.0343420588200927 0.917505640289818 -0.401020567899508 0.081599874011745 -0.4353626267196 0.0753980251051568 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WAC-AS1 0.0451981665434733 0.884088351288371 0.962072986521055 -0.133310888435117 0.656701045126176 0.871684912617742 False False False False False False False 0 insufficient_or_context_specific +ZFHX3 -0.0208890184934174 0.884163116898446 0.962072986521055 0.0590017923576746 0.680718824686932 0.881087330028764 0.233007648554977 0.271411271120872 2.0 -0.0082837016395349 0.981791385427173 0.233688668775179 0.336513023850605 0.225404967135644 0.38816829598517 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GOLGA5 0.0295844291399873 0.884299623715536 0.962074402771597 0.032463442666505 0.873047789229519 0.959263070839262 0.7775994361642959 1.14233384678471 2.0 -0.205077584960973 0.444978159545076 0.0136695574307695 0.957898983402731 -0.191408027530203 0.421380628945712 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ANKRD28 0.0342126996678106 0.884488316062288 0.962074402771597 0.0621562749533582 0.791674853910909 0.927588847807277 -0.300851038676151 0.395683996891609 -0.265656019065891 0.379245923627225 -0.566507057742043 0.085534485174979 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SARM1 0.0317316356189025 0.884531998790219 0.962074402771597 0.198220611763368 0.360335598206618 0.702830823178547 True False False False False False False 0 insufficient_or_context_specific +PUS10 -0.0388280387404788 0.884620032402601 0.962074402771597 -0.247602910240036 0.339961864578061 0.687345340140783 0.208832923487505 0.54197599541736 -0.647332257675699 0.0303985813323003 -0.438499334188193 0.152128992307482 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM69A -0.0390819544109741 0.885061357590524 0.962188174670382 -0.0658923978939721 0.808037687266068 0.932788199072101 False False False False False False False 0 insufficient_or_context_specific +HIBADH 0.0281380794263082 0.885124546961855 0.962188174670382 0.100258315126626 0.605781605543931 0.846820726734085 0.10725258228533 1.0 -0.659320161148527 0.0994130832760881 1.13452939231351 0.0082505763721285 0.475209231164984 0.194093119192605 reversed True False False False False False False 0 cross_species_direction_conflict +MTA1 -0.0267095085916833 0.885136209970815 0.962188174670382 -0.0464288981926151 0.802081776962142 0.930781165449847 -0.188808744918653 0.429163567942419 -0.238978305410478 0.234891651395861 -0.427787050329131 0.0561907356184618 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITPKB 0.0494848425889767 0.885180312613509 0.962188174670382 -0.0300704447627702 0.929650542807018 0.979967786975403 0.5605518383912479 1.0 -0.0532968215843618 0.870792851726127 -0.160181040959259 0.48836410822775 -0.21347786254362 0.379881921891787 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE2A 0.0352250222076644 0.885541453940496 0.962191838146186 -0.145018069698235 0.53511574517385 0.810930391494977 0.307383973483171 1.0 0.217762560147246 0.563432950576507 0.0536372397509942 0.873220568281053 0.271399799898241 0.399363067854252 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C9ORF85 0.0258611037023831 0.885578462497615 0.962191838146186 0.0521771986397358 0.772369620114701 0.921016314566412 True False False False False False False 0 insufficient_or_context_specific +CDC42SE1 0.0386274885185152 0.885611226876628 0.962191838146186 -0.350736433815752 0.165710801207168 0.545468009482397 0.563723065085264 1.0 0.0285262208720678 0.949750205790923 -0.180418444595149 0.55616516410136 -0.151892223723082 0.658934955745295 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC093503.2 -0.0511821788900227 0.885738534468805 0.962191838146186 -0.0836720895645869 0.815097599225831 0.935718218182704 False False False False False False False 0 insufficient_or_context_specific +CES1 -0.0707483091446292 0.885771775531633 0.962191838146186 -0.210279902382827 0.670380779369892 0.876638417082195 False False False False False False False 0 insufficient_or_context_specific +LRRC69 -0.033650356031121 0.885800584929837 0.962191838146186 0.0869851504682566 0.706637901769551 0.892997076377691 False False False False False False False 0 insufficient_or_context_specific +AC104389.4 -0.0403680920214883 0.885821620267184 0.962191838146186 -0.0082548150560976 0.976475628107045 0.992970766113577 False False False False False False False 0 insufficient_or_context_specific +CLEC4M 0.115589208618119 0.885933380785657 0.962214240750434 -0.0168939884046504 0.983230026250887 0.99451887511202 False False False False False False False 0 insufficient_or_context_specific +N4BP2 0.0293271049174739 0.886221068633735 0.962387914489754 -0.0216361646402497 0.915389300180206 0.974759629076879 0.0389793567180341 1.0 -0.88776865287152 0.0371712053901118 0.660217305253683 0.0674748285531909 -0.227551347617837 0.54510140064968 reversed False False False False False False False 0 insufficient_or_context_specific +FAM19A2 0.0525828213005366 0.886275591265758 0.962387914489754 0.602875201072204 0.134621639017849 0.521399583547485 0.0720618878636897 1.0 True False False False False False False 0 insufficient_or_context_specific +ADAM9 -0.0386648247299247 0.886486673258594 0.962419156428199 0.0894894986491577 0.732597101123569 0.904431845923655 1.34303831581925 1.0 -0.13334578428397 0.634935612993068 0.116432795164631 0.612521743034383 -0.0169129891193394 0.950559787025098 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC18B1 -0.0533059935528455 0.886656578044028 0.962447394747698 -0.14461053017312 0.695783845929102 0.888388661908266 0.918419457464956 0.0692296623979799 -1.10350057747829 0.0197347407745324 -0.185081120013338 0.729111396451669 reversed False False False False False False False 0 insufficient_or_context_specific +NGFR -0.08276379011141 0.886912756244307 0.962485655611555 0.310026161440722 0.60061797886234 0.84360251650955 0.067618278778092 0.895560263778032 0.0792869988098645 0.840127847163831 0.146905277587956 0.71610306801032 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE3A -0.0193456399779331 0.887021792877716 0.962485655611555 0.11620978069818 0.403151169745981 0.732213929838129 0.135787107590658 0.627013765539684 0.129183386911701 0.563636039781285 0.264970494502359 0.256059850693205 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZSCAN9 0.0555358827694181 0.887089529442025 0.962485655611555 -0.441183794491726 0.22560108263339 0.598165803727608 False False False False False False False 0 insufficient_or_context_specific +TBC1D8 -0.0322752885662341 0.887094896264069 0.962485655611555 -0.0297673582345842 0.89579824595773 0.96715797942752 2.4066764212008 1.0 -1.3114192176336 0.0150020259730402 0.738524739229954 0.09815875781029 -0.572894478403646 0.195010007206464 reversed False False False False False False False 0 insufficient_or_context_specific +STRBP 0.048016353708223 0.887330062731829 0.962552338175944 -0.147903722975399 0.661158755707662 0.872692182378332 -0.298435708630343 0.408165715768595 0.337892777517401 0.247942652883537 0.0394570688870581 0.916468942306155 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GATA2-AS1 0.102438482592062 0.887338691747155 0.962552338175944 0.285182939043857 0.703176595612808 0.891640364000942 0.6519249237249101 1.0 True False False False False False False 0 insufficient_or_context_specific +NPIPB5 0.0251490341531012 0.887490931473252 0.962556151313738 0.185848959843468 0.287718470982587 0.648118544193333 True False False False False False False 0 insufficient_or_context_specific +MED1 -0.0269213817041153 0.887574206848866 0.962556151313738 -0.160186450657335 0.384327812864361 0.719298323474503 0.4966758987409129 1.0 -0.121676436696276 0.67884606967272 0.219226672451865 0.325518933534891 0.0975502357555888 0.705831888568513 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTPN4 0.0278048416253374 0.887615712179442 0.962556151313738 0.140996589899166 0.464299296955563 0.769918639430946 0.315247571916303 1.0 -0.542702891675111 0.299324810267935 -0.503579311041101 0.274214325978029 -1.04628220271621 0.0472139468647175 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TRIM56 0.0245060166184278 0.887839316563995 0.962699753957344 -0.189735610882663 0.250337087811593 0.616672648883528 0.534531139023114 0.779490025132636 2.0 0.0167419665923055 0.961585435496815 0.203876855490896 0.384971445107528 0.220618822083201 0.377589848872004 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM241A -0.032247048417282 0.888002748608316 0.962756564849039 0.0569623937310688 0.805094282362659 0.932344568738067 0.807817319692983 0.155249777578458 -0.284352351919159 0.5162846527107 0.523464967773824 0.328257022622812 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIRREL1 -0.0433815925989645 0.888095232641674 0.962756564849039 0.140190869494457 0.648428830603246 0.86855377695836 0.257293311354188 1.0 False False False False False False False 0 insufficient_or_context_specific +RNF144A -0.0672602363545964 0.888165271986138 0.962756564849039 -0.658400212497256 0.152604426575602 0.535993857546643 0.460085587503349 0.248819760114183 -0.199917155177321 0.549220727011937 0.260168432326028 0.489473558410653 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC45A3 0.0592553649304151 0.888474662113291 0.96289421911231 -0.0285146938473971 0.949898782356175 0.986917609553614 1.30529687922313 0.804841590479016 2.0 -1.09058944606318 0.0058129846723132 0.628781166876398 0.0515795084370423 -0.461808279186783 0.146406527335482 reversed False False False False False False False 0 insufficient_or_context_specific +CLCN6 -0.0299293530118671 0.888683881186872 0.963022109983681 -0.206007040027311 0.322496342734136 0.672877524535327 0.3260794497471031 1.0 0.52778687279166 0.382191033435019 -0.481574240121398 0.295944233163252 0.0462126326702621 0.943910127720761 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZEB2 -0.0483487606586535 0.888822623921029 0.963029120966092 0.114502958820557 0.740844261815081 0.908406208990048 0.250260802573909 0.566737121999791 -0.186907240803551 0.610353542951864 0.0633535617703579 0.884254600643647 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C14ORF132 0.0557561120610045 0.889031297579915 0.963029120966092 0.415727011279028 0.327083241967944 0.676489102054191 True False False False False False False 0 insufficient_or_context_specific +RASSF5 -0.0300244564726382 0.889040015916568 0.963029120966092 -0.0738536105238376 0.733169083199463 0.904481167627122 0.5669413248144539 2.23283852668679 2.0 -0.267991717167835 0.454899803577486 0.0748437357529189 0.813044757473799 -0.193147981414916 0.553397724125437 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLEKHA1 -0.0211341107695157 0.889055203831834 0.963029120966092 0.0982829658300957 0.501273429820554 0.790861457269189 0.129944039355012 0.784039873542692 -0.774893195359155 0.0398324242259432 -0.644949156004143 0.100359027519763 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTLL11 0.028888085855919 0.889409129104793 0.963267156803712 0.14002588616599 0.489064297998519 0.783898718425439 True False False False False False False 0 insufficient_or_context_specific +LSAMP -0.0551043402011872 0.889457426755009 0.963267156803712 -0.264725328034108 0.500726281611728 0.790819493321426 False False False False False False False 0 insufficient_or_context_specific +TMEM71 -0.059903297226112 0.889549077738284 0.963267606437005 -0.40722934012931 0.326127214818602 0.675544660399215 -1.18098127001874 0.191869477491155 1.02070658805584 0.167423699717041 -0.160274681962898 0.850264753005949 partial_or_other False False False False False False False 0 insufficient_or_context_specific +METRNL -0.0590744145290929 0.889850785907835 0.963495497653053 -0.530212022217832 0.187320610445292 0.56929178900529 0.836899736032823 1.0 0.580355015445777 0.1073649362314 -0.667266699519565 0.0422907843958007 -0.0869116840737876 0.820024377058458 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ETFB -0.0381794372055211 0.89008198909666 0.963647009934633 0.27122725864656 0.339866405638161 0.687324315838944 -0.387853407622475 0.413965145544271 0.472318135046322 0.24192246749082 0.0844647274238474 0.861071568106089 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF253 0.0393109644286722 0.890426530091491 0.963681627079609 -0.106302014611152 0.708047244430505 0.893638108503159 False False False False False False False 0 insufficient_or_context_specific +HM13 -0.0324177414263037 0.890552530030971 0.963681627079609 -0.0624349540702388 0.790038183957708 0.927375594093834 0.117690705911847 1.0 False False False False False False False 0 insufficient_or_context_specific +CEP250 0.0311807014982519 0.890607027662734 0.963681627079609 -0.249788806390057 0.239326112019783 0.606713331305531 -0.0787844400801693 0.851979752784339 -1.274693593452 0.0026194840581572 -1.35347803353217 0.0033887156459166 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIGU 0.0364140147366016 0.890620668997833 0.963681627079609 -0.283698112163312 0.277372090608571 0.64071639456045 0.250764635452479 0.4498909870042 0.147373023559754 0.584391924482434 0.398137659012233 0.172621494633672 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RRAGC -0.0452338320203932 0.890635967491647 0.963681627079609 0.143027258732839 0.665789748930904 0.87511808324756 0.0826674048390229 0.836933962693437 -0.120575340468274 0.675850535481647 -0.0379079356292516 0.915396363897615 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GGT1 0.0335145530226212 0.890661613661946 0.963681627079609 0.396072226097078 0.115689787091158 0.494115199072994 True False False False False False False 0 insufficient_or_context_specific +PUM1 -0.0167667889941524 0.891272222300862 0.964243480177528 0.0673278993836363 0.581638950372483 0.83332444054994 0.7584300416737499 1.0 0.0146882141232555 0.963257176400296 -0.118000463146636 0.594816343345439 -0.10331224902338 0.675964669065056 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PHAX -0.0383333958737397 0.891534714333441 0.96428219259087 0.316280874974221 0.281730881271539 0.64315368591277 0.176897974474533 0.550622074043692 0.0031533561188466 0.99121310673798 0.18005133059338 0.486356389872667 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZRANB1 -0.0187288177948191 0.891562149149689 0.96428219259087 -0.0806814343287051 0.55406355869133 0.819759396393367 1.7472006665314 1.0 -0.385601284310652 0.153437828063292 0.0912106941616456 0.714805018800508 -0.294390590149007 0.235288020367028 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF566 -0.0225957721935508 0.891896715956611 0.964478540082315 -0.187696336597836 0.24735776324193 0.612764726491859 False False False False False False False 0 insufficient_or_context_specific +DNAJC13 -0.0297327092615894 0.891946683992877 0.964478540082315 0.212558004679074 0.32497721116244 0.674724889947951 0.23752933861733 0.434800074868626 -0.292781111090398 0.24255642164574 -0.0552517724730677 0.858370509832168 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPATCH2 0.0265687879685682 0.892096233432358 0.964478540082315 0.23254972012844 0.229732073085853 0.601091682478031 -0.386646080776772 0.27276841352543 -0.507047239339618 0.10820363302456 -0.893693320116391 0.0187407173458321 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ADGRL2 -0.0423370549206727 0.892155913087957 0.964478540082315 0.138970760500045 0.663285967807957 0.87427880750517 0.0257977316183027 1.21929580999444 2.0 0.179320926444155 0.574518471018978 -0.0740566617012615 0.785539912687646 0.105264264742894 0.721586721852524 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARHGEF6 -0.034511903387661 0.892261412990832 0.964478540082315 -0.293154263918132 0.220257554833976 0.59217704709374 -0.052903100094665 0.912863180790051 -0.0119500969616632 0.974525901235928 -0.0648531970563282 0.870346040498399 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00909 -0.039564505283787 0.892385900031236 0.964478540082315 -0.194229275583944 0.49535351187843 0.787761581375387 False False False False False False False 0 insufficient_or_context_specific +CASP9 0.0816304526467978 0.892402998490636 0.964478540082315 -0.428333905381701 0.464816578983269 0.770230855975455 0.5015045644807811 0.259072932356075 2.0 -0.0134620140629164 0.970068925563657 -0.0993861676294143 0.692503330079297 -0.112848181692331 0.688030642577983 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZKSCAN8 0.0302775690393372 0.892532882723227 0.964520181759655 -0.0548621001787043 0.810033215929237 0.93324967646402 0.274037795735313 0.4498909870042 -0.459757874573927 0.126243873965407 -0.185720078838614 0.584315134287633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBBP6 0.025089370184514 0.892645046132083 0.96454266677541 -0.129468835480656 0.482329804210873 0.780666906162311 0.550032185558661 0.0570179712176716 -0.322242341386904 0.18488799334859 0.227789844171757 0.388520364435509 reversed False False False False False False False 0 insufficient_or_context_specific +CCDC77 0.0373723795445599 0.892904037435159 0.964683168885101 -0.149134424814061 0.582404964039801 0.833494998054781 -0.0170850638788832 0.972359389930452 -0.634542052814275 0.0717648389432975 -0.651627116693159 0.095160844260148 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HABP4 -0.0343772696182643 0.893051854695582 0.964686052985058 -0.0262679386068834 0.918226984568292 0.975930957742715 1.35229807325816 1.0 -0.309402255885312 0.352024768812786 0.225343178031507 0.428872722910059 -0.0840590778538053 0.800798170345124 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HNRNPA0 -0.0445843107997946 0.894014941146377 0.965528820440205 -0.389475914867879 0.22159480578586 0.592957341103408 0.115926872997404 1.0 -0.181146482017082 0.54197599541736 -0.392303415433859 0.113319981192221 -0.573449897450941 0.0390573639841184 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ORAI2 -0.042200048800976 0.89414382176898 0.965569241100224 0.0928474905019709 0.772579689280486 0.921162773509132 0.446390089304091 1.0 0.280768319549736 0.738059229929372 -1.14792789075581 0.079997870138522 -0.867159571206078 0.246096477243904 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM177A1 -0.0290604909401183 0.89464433752293 0.966010934298128 -0.147774651269057 0.49686679861287 0.788978742631175 False False False False False False False 0 insufficient_or_context_specific +HEATR3 -0.0355758912570229 0.895042047110888 0.96634154140472 -0.0380902097177987 0.887740592929309 0.963978728802596 -0.0935768600360862 0.831245542151547 -0.396879665735779 0.196789569338921 -0.490456525771865 0.146440268819089 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HNRNPU -0.0238171096775836 0.895133723580344 0.966341702818126 -0.0007488262143178 0.996698889830681 0.998795540446485 0.418911192621318 1.0 -0.215599523604605 0.46380760820527 -0.405958912739798 0.107012539618596 -0.621558436344404 0.030069015322369 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADAM19 -0.032325804228186 0.895522927424724 0.966564206476205 0.0245788492017111 0.918689339812375 0.975930957742715 0.5935489486889179 0.6731614811300279 2.0 1.28562326026109 0.0036044741243049 -1.74007029694112 0.0009226106283564 -0.454447036680031 0.218205638657339 reversed False False False False False False False 0 insufficient_or_context_specific +POMT1 -0.0431582772621455 0.895902507830552 0.966875053300581 -0.291027973496764 0.357393431146729 0.701288497271586 0.671838702721542 1.0 0.238175498800535 0.515486103778002 -0.388375903572585 0.18527871730198 -0.150200404772051 0.662763506537615 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OTULIN 0.0325974660447723 0.896025723871842 0.966875053300581 -0.182271057629303 0.454158287716107 0.765695541335292 -0.194817479721247 0.539721668134273 0.19483894920216 0.451276394050772 2.14694809128435e-05 1.0 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM116 -0.0461936506451013 0.896099959567989 0.966875053300581 -0.0893990989298397 0.80059324937537 0.930088303753618 0.0180514451990048 1.0 False False False False False False False 0 insufficient_or_context_specific +GRID1 -0.0748355784984829 0.896194077496371 0.966875053300581 0.679835240508285 0.241058885141748 0.608360603787226 0.0643579234804211 1.0 -5.45576015482297 0.0032080996527815 6.23828629169754 0.0008632955010727 0.782526136874569 0.289164895251086 reversed False False False False False False False 0 insufficient_or_context_specific +STK39 -0.0425786669762525 0.89627110872112 0.966875053300581 -0.0328363045110082 0.919930605539502 0.976045355570903 0.25734444832995 0.554755355720432 -0.761334042088446 0.0448205329172076 -0.503989593758496 0.184064403450931 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DIMT1 -0.0352325850131511 0.896452399181239 0.966875053300581 -0.336669347265586 0.211777461183917 0.584255666365245 -0.0361471663125537 0.935331104162104 -0.757340375534324 0.0233695746073517 -0.793487541846878 0.0284055464146005 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TIPRL 0.0355016318079911 0.896542758949711 0.966875053300581 0.211507019511092 0.435900452908366 0.753451320678163 0.293138193526276 1.0 -0.0843761578506015 0.774555303144519 -0.0213583574629272 0.931942990277106 -0.105734515313529 0.669302355009092 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAGI3 -0.0274623785080552 0.896552150382412 0.966875053300581 0.200228747401001 0.343520249690753 0.690309630040916 0.0733405194023936 1.0 -0.250868016980542 0.390623309465468 0.325762377026727 0.176894538201999 0.0748943600461849 0.794949587592665 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM136A 0.0465530400756315 0.896635124726841 0.966875053300581 -0.0951404735298362 0.809562323102033 0.93302493406858 -0.0424285037105161 0.928457635800105 0.396986025561414 0.189799867813803 0.354557521850898 0.2775836051235 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLA2G6 -0.0423631950757327 0.896907618738012 0.966901529562418 0.0235694420421621 0.93838961799871 0.983376435417407 0.297106101815192 0.563095966281006 2.0 -0.384911572945974 0.319547673789427 0.256469994319426 0.436674079469168 -0.128441578626548 0.734870543265013 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC7A6OS 0.0340317411218893 0.897129247916718 0.966901529562418 0.181150196461219 0.500572969894865 0.790819493321426 -0.223154946969782 0.347380590871551 -0.490144483555551 0.0297827090668634 -0.713299430525333 0.0085974855976623 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HMGCL 0.0307441140448929 0.897159256179041 0.966901529562418 -0.0435054321391713 0.854336545007083 0.95526155065304 -0.452000159009941 0.253527113927117 0.833079419656499 0.0286031397647717 0.381079260646558 0.289820467036452 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KDM1B 0.0445985648190662 0.897238924706054 0.966901529562418 0.255930492363601 0.465201179331126 0.770566998961096 -0.173044753190251 0.674738380986663 0.366563867768401 0.225441660257634 0.19351911457815 0.574346661920491 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GLIS1 0.0366798849116926 0.897396891182727 0.966901529562418 0.0452914814381665 0.873861559016888 0.959366781751097 True False False False False False False 0 insufficient_or_context_specific +DYNC1LI1 -0.0222758997645765 0.897517272840446 0.966901529562418 -0.0256950474728496 0.881656102838191 0.962618478946739 0.36675103116849 1.0 0.205577178851723 0.426737081292997 -0.288420525207755 0.181346342106623 -0.0828433463560313 0.741854073547932 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TWSG1 -0.0367337985537553 0.897728542075284 0.966901529562418 -0.231681865359432 0.41503506003403 0.737079926634026 0.3081488423931 0.327396177338941 0.171647689671756 0.524786591895754 0.479796532064856 0.100339545873054 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYP27A1 -0.0257903039085918 0.898082638871598 0.966901529562418 -0.0675303498070013 0.738905940886196 0.907558041400239 -0.844688417303612 0.0597335364523075 1.06873986700939 0.0167992038807942 0.224051449705778 0.595139012396859 reversed False False False False False False False 0 insufficient_or_context_specific +TAF3 -0.0232129822391145 0.898107956107245 0.966901529562418 -0.0487362669783144 0.787969761932128 0.926576536501901 -0.317685186789692 0.589184956781256 0.183625985401217 0.700043498049031 -0.134059201388475 0.807662894892962 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ALG11 0.0446765157693789 0.898121204905937 0.966901529562418 0.0013753109425099 0.997038631920119 0.998795540446485 -0.0045818350431724 0.992110993471489 0.0337017168963055 0.915025892720074 0.029119881853133 0.933570137924784 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM174B -0.0337329332823243 0.898143329093003 0.966901529562418 -0.150121765092372 0.567411780014971 0.824849995454606 0.4696611618192921 1.0 -0.316138660682941 0.560983902319736 -0.0550376900405934 0.91098651474145 -0.371176350723535 0.428232454788778 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC105052.3 -0.037466844426191 0.898180019722934 0.966901529562418 -0.0962856927439693 0.741869539760033 0.908944286552716 False False False False False False False 0 insufficient_or_context_specific +AC090709.1 -0.0634791603684152 0.898216537407482 0.966901529562418 -0.0989175492267429 0.841643955880029 0.949874600340068 False False False False False False False 0 insufficient_or_context_specific +RAF1 -0.015210540207542 0.898437419926031 0.966994787121229 -0.0552011992250909 0.640304046778689 0.864640237429136 -0.0372183314469705 0.908949182532723 -0.344405734962477 0.124631191749373 -0.381624066409448 0.107363653545923 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KREMEN1 -0.0339214285924529 0.898486347950299 0.966994787121229 0.109447290593387 0.6829809492451 0.882176763167331 0.86822819316513 1.0 -0.44537853875557 0.259768209422342 0.300894465184266 0.36419680401427 -0.144484073571305 0.707978911791892 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UPP2 0.0610185465482086 0.898720253973935 0.966996040341054 0.172662774199837 0.724124798225463 0.902378599287888 True False False False False False False 0 insufficient_or_context_specific +ADPRHL2 -0.0370019666719033 0.898864916339044 0.966996040341054 -0.310956077240962 0.266794104710526 0.629877494976238 0.341081627660105 1.0 -0.357537557503852 0.199102989203055 0.0300093714915329 0.915025892720074 -0.327528186012319 0.202281672751576 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CLCN5 0.0312773388580295 0.898893992796932 0.966996040341054 -0.0407198951087405 0.869176377485581 0.958502690861149 0.214207594014232 0.694008504879575 -0.678045891315326 0.10429959522678 -0.463838297301094 0.323463038417611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF215 0.032257104769316 0.899219048791359 0.966996040341054 -0.115891232105068 0.636962754140222 0.862296801924921 0.0980374933762066 0.773402482852107 -0.595061837690524 0.0318907698878728 -0.497024344314317 0.0768261668107177 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACTR5 -0.0407853877272151 0.899222556369985 0.966996040341054 0.0335748636437803 0.917860230719943 0.975930957742715 -0.224518620703473 0.603226373915281 -0.134637061664772 0.706471819094776 -0.359155682368246 0.328867758757767 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RFX3-AS1 0.0352368984185994 0.899236291793655 0.966996040341054 0.0728688106770244 0.792868193883001 0.927620871373898 True False False False False False False 0 insufficient_or_context_specific +CD99L2 -0.0295340244125312 0.899261535039348 0.966996040341054 -0.152965590566397 0.503872951594227 0.792593954548845 0.3511932341910939 1.0 -0.172396006348469 0.566693700192947 0.433848529410904 0.0753828870693577 0.261452523062435 0.300423306371475 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAMDC2-AS1 0.0362703781589175 0.899445355780204 0.966996040341054 -0.175980281963949 0.527195888188151 0.804819865166353 1.30305803475183 1.00295456994307 2.0 False False False False False False False 0 insufficient_or_context_specific +RNF144B -0.0617863416929177 0.899522032499528 0.966996040341054 -0.16777615424942 0.731936762687444 0.904431845923655 -0.95323734314369 0.061479475912415 0.59201701887589 0.173696243036642 -0.361220324267801 0.422462322435299 reversed False False False False False False False 0 insufficient_or_context_specific +CLDN15 -0.0403137826597907 0.899711207049212 0.966996040341054 -0.0813078307399892 0.797751515590927 0.92925379048471 -2.0488450291084 0.0048991411542057 1.04668058797523 0.0720869260610636 -1.00216444113318 0.0768010470857484 reversed False False False False False False False 0 insufficient_or_context_specific +REX1BD -0.0449756022758459 0.899769757559245 0.966996040341054 0.0389021488190863 0.910507448734965 0.972012437182896 1.34492543820357 0.0140983670507399 2.0 -0.535898895395779 0.0780720615753492 0.617998663972495 0.0300421110018106 0.0820997685767158 0.787423260243664 reversed False False False False False False False 0 insufficient_or_context_specific +AGO2 -0.0262858003104016 0.900074863797005 0.967225487223285 -0.0665354390928466 0.749222118970512 0.910804141680369 1.03170695600316 0.10079052456608 2.0 0.0981787344382835 0.732775336828021 -0.349090064227034 0.115194262178837 -0.25091132978875 0.281875388881488 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CSNK2A2 -0.0227929454350252 0.900316414544805 0.96736903198115 -0.0295625201951361 0.870756729537433 0.958683313195135 0.132764790057483 0.681898840040898 -0.225272787912432 0.355408290279068 -0.0925079978549496 0.752485180828794 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COL26A1 0.0728300700510631 0.900472260517224 0.96736903198115 -0.426872258540515 0.465700123202683 0.771030563082003 False False False False False False False 0 insufficient_or_context_specific +ZNF460 -0.0348971962764184 0.900636837293211 0.96736903198115 -0.359720901989711 0.208013602869381 0.580700057930969 False False False False False False False 0 insufficient_or_context_specific +STAT3 0.0296862884589764 0.900647015132807 0.96736903198115 -0.128524519650368 0.597347184080921 0.842140682270845 0.263225599937221 0.530000016475026 0.150232598924241 3.0 -0.595249181278216 0.0990934848524984 0.149894375807509 0.651490376192322 -0.445354805470706 0.180860734281678 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNX16 -0.0387012921210652 0.900973900170363 0.967600695554744 -0.0313508026376158 0.919873691679848 0.976045355570903 0.398736505422652 0.357118365608029 -0.145842822312028 0.678607557209557 0.252893683110624 0.535804547819139 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SPATA6L 0.0436131913891195 0.901178279135201 0.96772175255385 -0.0404837168054458 0.909656988660397 0.971785741806786 False False False False False False False 0 insufficient_or_context_specific +CTH 0.0935030977723817 0.90140216657546 0.967768114470818 -0.0033903698948044 0.997344983521957 0.998801457112118 -0.59692946053971 0.217181565983641 0.553760441961253 0.196254904474676 -0.0431690185784574 0.933602644063331 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARL6 0.0349764327569076 0.901493826119425 0.967768114470818 -0.0019787943570313 0.99378823190311 0.998542598236847 0.0091429595443764 0.989165574768777 0.191514717208788 0.652469085692021 0.200657676753165 0.685457419942048 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SRPK1 0.0230046249091947 0.902026682092253 0.968169879037566 -0.100266392291373 0.597857951015814 0.842410816338578 0.298761900428223 0.291992895520755 -0.595152613270646 0.0277698086125162 -0.296390712842423 0.25499702758315 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC24A1 -0.0350639051235653 0.902054091692796 0.968169879037566 -0.0701968801058778 0.804068186195066 0.931585378484075 False False False False False False False 0 insufficient_or_context_specific +STAB2 -0.0919128343296346 0.902217032193272 0.96824633318729 -0.529487849307867 0.469206248749853 0.773450043889281 0.434402117574016 1.0 -0.346082248291784 0.485462725443875 -0.258831308664108 0.538539939904768 -0.604913556955892 0.166830055698032 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMARCAL1 0.0283446939103322 0.902502942191397 0.968292662761024 0.092454093939156 0.689935403212327 0.885210584988815 -0.12195196632398 0.777586261152974 -0.18288212289998 0.566245290147608 -0.304834089223961 0.37305938205724 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PEX6 0.0229830785184169 0.902594522449738 0.968292662761024 -0.162329787946833 0.392986423803013 0.725225989961407 -0.567141289237019 0.0796349841669779 0.0979197417701827 0.746819243489507 -0.469221547466837 0.119366436689287 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CPEB2-DT 0.0458038511672558 0.902752098373829 0.968292662761024 -0.11287582099293 0.766618357497142 0.919349911228398 False False False False False False False 0 insufficient_or_context_specific +PHF11 -0.0217591226510824 0.90277760958307 0.968292662761024 0.186479442175828 0.265893835698903 0.628408079081913 0.434708073841383 1.0 False False False False False False False 0 insufficient_or_context_specific +ZNF621 0.0270647330358591 0.902872301618681 0.968292662761024 0.115372874257682 0.598828366662754 0.842765915119348 True False False False False False False 0 insufficient_or_context_specific +MGAT4C 0.0617966513715122 0.902902184588206 0.968292662761024 0.287518530988682 0.565492873473322 0.823968224969823 0.576640109292376 1.0 True False False False False False False 0 insufficient_or_context_specific +ZBED3 0.0544228843372916 0.903089950359282 0.968395662796394 -0.0463726584812518 0.91897968216234 0.975930957742715 -0.0692767267931054 0.893060773281333 -0.586212681627873 0.104317387711355 -0.655489408420979 0.0941328745217053 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PCAT1 0.0637767138090562 0.903409507465811 0.968443644441176 -0.070033792395311 0.893741018011746 0.966122419183784 0.259332742684232 1.0 False False False False False False False 0 insufficient_or_context_specific +TRAPPC13 -0.0286251457858571 0.903486967189828 0.968443644441176 0.0237879395182035 0.920237701389489 0.976218550995966 0.184930992457596 0.521218168225128 0.141528105357339 0.534688835450744 0.326459097814934 0.188758850947986 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPFIA1 0.0159597637941065 0.903501600468421 0.968443644441176 0.0038759512104918 0.97640529811946 0.992970766113577 -0.195498901060721 0.415382455534496 -0.48786333091628 0.0296528162411986 -0.683362231977 0.0098874070618088 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IRF2BP2 0.0403796247147504 0.903798313232298 0.968497346354868 -0.226881186143124 0.488755105787972 0.783641064071284 0.218847239544834 0.51831701389063 2.0 -0.686081426033847 0.0819009008578608 0.208090966567058 0.556825176857364 -0.477990459466788 0.187156648302077 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TTC23 0.0189778813957807 0.9038239598803 0.968497346354868 -0.0683147667373659 0.656726228722742 0.871684912617742 0.143696711962496 0.653396314246701 0.124344405431447 0.627063926699736 0.268041117393943 0.310100188256524 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FARSB -0.0327825702757038 0.903895395910357 0.968497346354868 0.19690065271336 0.46312376462251 0.769320698854699 0.428584969207725 1.0 -0.0636959604744726 0.868689988027735 0.4522936818484 0.0855848027772051 0.388597721373927 0.163796385556228 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PSME3 0.0391344209331143 0.903918625779586 0.968497346354868 -0.0024706034267839 0.996571306224463 0.998795540446485 -0.23980249001023 0.387618592642 0.160398580068392 0.501115140549912 -0.0794039099418384 0.77231360332882 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GBP4 -0.0620618746164197 0.904174902383908 0.968673629565631 -0.0050109157617771 0.992324614023918 0.998236115892821 0.5349497083568421 1.0 -0.441647878038097 0.344459503738093 -0.442127971106548 0.275102635365299 -0.883775849144645 0.05352014456082 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARAP2 -0.0558046570758869 0.904436032728398 0.968855076455604 -0.132386498832067 0.774850637501264 0.921907331897703 0.391711592016843 0.274973819582601 -0.629470757025626 0.0566642903850071 -0.237759165008783 0.479473922335077 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CEBPG -0.0421965770301637 0.904532370003925 0.968859973876579 -0.317227044224319 0.358805653468731 0.70231184451666 0.24408221575075 1.0 -0.0038072425333904 0.992862411288349 0.169212519798403 0.542830068014547 0.165405277265012 0.584315134287633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HKR1 0.0184475842452141 0.904673233592074 0.968912558355155 -0.0055215624629123 0.97184591923764 0.992040338141303 False False False False False False False 0 insufficient_or_context_specific +DCLK2 0.036038591675811 0.904872525898521 0.969027703462479 0.262802064391307 0.374828182996488 0.712838905321506 0.00409157311180841 1.0 -0.223784818281683 0.614576850042954 -0.451255361205965 0.204590862502895 -0.675040179487648 0.085072094474002 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZSCAN16-AS1 0.0302585096540173 0.905129121233278 0.969049396191602 0.299999606815768 0.262007631334771 0.624723706330739 0.0203440485578808 1.0 True False False False False False False 0 insufficient_or_context_specific +DHRS4 -0.0511316934027467 0.905168132718467 0.969049396191602 -0.558030549790211 0.189245826107588 0.569886897607216 0.3655584827620971 1.0 -0.308195527512757 0.38692805555038 0.629192414648258 0.0497435923782537 0.3209968871355 0.310437186246948 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PI4KB -0.0177542997770226 0.905317053358418 0.969110559602371 0.0878323014328577 0.541921991262796 0.813940850536852 -0.544449270060174 0.095246136777706 0.648898273361135 0.028116679265099 0.104449003300961 0.739642982650771 reversed False False False False False False False 0 insufficient_or_context_specific +AC009961.1 -0.0414204856395552 0.90596634880505 0.969545924600497 0.221763292789538 0.538603243944491 0.812290593659906 False False False False False False False 0 insufficient_or_context_specific +HLA-DRB1 0.0610469270102759 0.905992228654617 0.969545924600497 0.142386987789285 0.783095796760875 0.924823872729453 True False False False False False False 0 insufficient_or_context_specific +CTR9 -0.0251687377521271 0.906148679724128 0.969545924600497 0.0318634897345562 0.877128777589542 0.960989240400635 0.475063951769484 1.0 0.36832860189265 0.148930737186718 -0.216295060575892 0.314178977613949 0.152033541316758 0.534760010577173 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CDH1 0.0626658915241144 0.90618291191113 0.969545924600497 -0.0331761045609716 0.950597638818919 0.986917609553614 -0.229824612250715 0.65823513245608 0.486343725899925 0.211009224312063 0.25651911364921 0.5572780050764 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERMP1 0.0275714991608087 0.906671732906183 0.969935890904237 0.063793477264032 0.785762723283359 0.926005450655844 -0.0910970410727983 0.815136132477854 0.0322526986471509 0.91956626594557 -0.0588443424256474 0.862329066522889 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARNT 0.0175081414680505 0.906731127412846 0.969935890904237 -0.0702926997501133 0.638369083791512 0.863438120767827 0.468976142221202 1.0 -0.0707654350335037 0.786138231368709 -0.131170225359961 0.501409796355128 -0.201935660393465 0.321406463935889 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZFPL1 0.0453806326526268 0.906839409362411 0.969953447882518 0.0035644507302769 0.991306760336934 0.997542582504513 -0.0681731936831859 0.871088217919342 -0.236195060705324 0.418924372985231 -0.30436825438851 0.329967285853047 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MCTS1 -0.031587176450953 0.907061154577422 0.970089952147654 0.260485147672224 0.344951506276827 0.690926371085492 -0.399514417996048 0.139143488023485 0.319612140042195 0.173099545810222 -0.079902277953853 0.769844866771406 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR90 0.0398234874189215 0.907562518356863 0.970089952147654 -0.0385387053573044 0.912939131097054 0.973464340430836 0.0373314895843538 1.0 -0.177429818099008 0.726077283679401 -1.04325667495223 0.0207866613349705 -1.22068649305124 0.0176451731520105 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POGZ -0.0133903902810229 0.907590822598077 0.970089952147654 -0.0215376769325263 0.850499006742791 0.953542892413951 0.00677187089632703 1.0 0.226271298560023 0.432867001354305 -0.307783879097118 0.196385267215777 -0.0815125805370948 0.775525950659292 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PIGX 0.0385212586395071 0.907596359274979 0.970089952147654 0.130713745879974 0.701017512801718 0.891032869481905 0.318471742925445 1.0 -0.123010204522536 0.836933962693437 0.389066793834372 0.31549367059548 0.266056589311835 0.553819394688433 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PPP5D1 -0.0314878020360394 0.907610205276996 0.970089952147654 -0.103084345664237 0.702498845362173 0.891573566867428 False False False False False False False 0 insufficient_or_context_specific +PUM2 -0.0152995539266442 0.907771004794252 0.970163606500427 -0.0730589701035043 0.574732970501778 0.829305822407786 0.402542858779397 1.0 0.141463341780391 0.657621361749534 0.115694560557577 0.652182036494252 0.257157902337967 0.327854353621058 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BAIAP2L1 0.0393224878245014 0.907896480869612 0.970199498483944 0.210044203639599 0.536923942236348 0.812087893451657 -0.536486271912058 0.122148616657771 0.315313732842446 0.292454387111874 -0.221172539069612 0.493271491051335 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NCOA5 -0.0230854142189063 0.908278285564036 0.970256333202762 -0.0181302657949438 0.927880051354921 0.979087152943213 0.509822925412142 1.0 -0.0716694733841741 0.787647587732967 -0.264137855221332 0.180982608516156 -0.335807328605506 0.113718054790355 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRRK2 0.0282242614443438 0.908366622994583 0.970256333202762 -0.0341648449515609 0.888586599709301 0.964276699808303 0.0378098752207157 0.939953142486704 0.0057305461305699 0.988665629929683 0.0435404213512857 0.917335477477782 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL591895.1 -0.0287778270001448 0.908368449978159 0.970256333202762 -0.146725453720787 0.554036267697668 0.819759396393367 False False False False False False False 0 insufficient_or_context_specific +LAMTOR4 0.0398109778394862 0.908422989703453 0.970256333202762 0.11741480507259 0.74274753018352 0.909209092600302 0.168915124897972 1.0 -0.577650971710056 0.0583073675213567 0.336575786237962 0.193190598273349 -0.241075185472094 0.377916846535421 reversed True False False False False False False 0 cross_species_direction_conflict +USP7 -0.0155554231036963 0.908592950026113 0.970256333202762 0.0325780422832804 0.809193849425549 0.932943578867351 -0.130677909482742 0.613906176861948 -0.0170444785954277 0.943639832574209 -0.147722388078169 0.50740799346491 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE2L6 -0.0448783184437468 0.908755507308124 0.970331780558169 0.116576196152784 0.771664876970372 0.920641521976153 0.109625433628518 0.715407116185129 -0.0536083244081035 0.831040170492243 0.0560171092204142 0.840937704539414 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNAP25-AS1 -0.072502273803459 0.909011817231444 0.970491890524477 0.382221012372542 0.559044248624892 0.821716438393653 False False False False False False False 0 insufficient_or_context_specific +MBNL3 0.0438510823638442 0.909280416196764 0.970491890524477 -0.186955965517712 0.620381427249971 0.854153589708151 False False False False False False False 0 insufficient_or_context_specific +BIN3 -0.0281904333474225 0.909357770124724 0.970491890524477 0.0318492121853763 0.896880960766193 0.967531580672392 0.9557986111251751 1.0 -0.145995524663408 0.664875881263502 0.052009512375672 0.857359525187459 -0.0939860122877358 0.758331261947774 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MIATNB 0.0247472406257361 0.909384325684798 0.970491890524477 0.033982693843157 0.875707996644004 0.960395245514428 0.310219942320291 0.715299723222778 2.0 True False False False False False False 0 insufficient_or_context_specific +SPPL2A 0.0170631328110507 0.909456977159422 0.970491890524477 0.12322486310251 0.393305779364344 0.725247545582736 0.633768698137421 0.0900740107659639 2.0 -0.368899261723516 0.26375158794362 0.59122515010951 0.0503768674322141 0.222325888385994 0.462035478702738 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MUC3A -0.08061063683399 0.910026232092294 0.971001208532636 -0.171742782237909 0.806373547350079 0.932788199072101 False False False False False False False 0 insufficient_or_context_specific +RGL1 0.0323741825710836 0.910253928181891 0.971146015940219 0.0035787566765488 0.99009814411986 0.996896452948454 0.291391265396986 1.0 -0.347924192291681 0.31855848329194 0.202773213916156 0.50716187040078 -0.145150978375525 0.667993848605525 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PCTP -0.0301580554804187 0.910435045404434 0.97124110431242 -0.217489018428106 0.384562278588382 0.719298323474503 0.178462292924563 0.789307296833914 0.555409849821597 0.234088290580622 0.73387214274616 0.154700677779838 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CEP112 -0.0287928552124513 0.910643418812577 0.971365247102767 0.180545264496334 0.477555902401398 0.778545319644225 0.293750707051765 1.0 0.857199555499755 0.14439232650593 -1.6024967024303 0.0084536844581115 -0.745297146930545 0.241275005315171 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF652 0.0209459450052383 0.910872917404045 0.971471563265343 0.178201799725297 0.335008065303648 0.684461073909613 0.283528329615405 1.0 True False False False False False False 0 insufficient_or_context_specific +DBF4B 0.0437498096068697 0.911306317571676 0.971777810415286 -0.370651756756797 0.304613953369092 0.661341495477036 False False False False False False False 0 insufficient_or_context_specific +KLF3 -0.0323122105250614 0.911679501380857 0.972022756887302 -0.417538124436976 0.115506519447268 0.493786316225751 -0.130627489692671 0.647352963989451 -0.0166053236770263 0.949547299972159 -0.147232813369698 0.548851241821563 partial_or_other False False False False False False False 0 insufficient_or_context_specific +JUN -0.0631664523803184 0.911720151681659 0.972022756887302 -1.35522477281392 0.0247364776467567 0.349622129845324 -0.431776963601219 0.132127484828182 0.330407033072822 0.190209612649636 -0.101369930528397 0.722612486763384 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CENPP -0.0316107344875803 0.91186798536881 0.972082208150636 -0.0448454194598738 0.875625038318285 0.960395245514428 False False False False False False False 0 insufficient_or_context_specific +KIF12 0.0873554793619855 0.912094075160495 0.972198536373701 0.135204188557474 0.867407147435481 0.958502690861149 0.610359886883389 1.0 True False False False False False False 0 insufficient_or_context_specific +NCOA6 -0.0144075622858171 0.91216127119889 0.972198536373701 0.108418300398216 0.421451340556346 0.743348355094203 1.21328313468639 1.0 0.0925823155022272 0.754677169132923 0.260877989974382 0.225442413043454 0.353460305476609 0.13268280619947 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC9A5 0.0351326484234284 0.912266507484127 0.972212555366651 -0.0071136178517135 0.983924790912124 0.99451887511202 0.352353294512847 0.475377726439179 -1.57186021939406 0.0043738300087343 -1.21950692488121 0.025159783210507 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL20 0.0174286340659193 0.912454168265787 0.972314403365985 0.0872238529245118 0.582557942710351 0.833533915047552 -0.0258937649619075 0.966207613013091 -0.247952078122263 0.543203655915514 -0.273845843084171 0.556371260998904 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GNB4 -0.0317698503489008 0.912650784369576 0.97233510303033 0.141291045917161 0.620592175284261 0.854153589708151 0.440792391614304 0.152269271175617 -0.142892136858899 0.581902097632955 0.297900254755405 0.296922304960487 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MCUB -0.0350619431135743 0.912810062339991 0.97233510303033 0.0931605426562166 0.774400049704043 0.921907331897703 False False False False False False False 0 insufficient_or_context_specific +INTS9 -0.0292119719235302 0.91295118839436 0.972353338753924 0.0894527597734179 0.740268996504627 0.908274440555399 -0.113140718361435 0.792056498532133 -0.124933201216744 0.698243579301301 -0.238073919578179 0.486096272272659 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF1AY -0.095850494720863 0.913059718470578 0.972370839985109 -0.838574698373349 0.316773959317441 0.669290253214092 False False False False False False False 0 insufficient_or_context_specific +SEC24B -0.0185539916335758 0.9133253532414 0.97241584900996 0.112485226557395 0.505947056638135 0.793374279516625 0.125985477045687 1.0 0.394208444379939 0.200820081464291 -0.0145309538110921 0.961891143188189 0.379677490568847 0.183136245163124 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTER 0.0203439070857668 0.913483130403371 0.97241584900996 -0.0008410577245931 0.995827820139276 0.998795540446485 -0.046119264540448 0.914881531455775 -0.3034321967051 0.289148610908688 -0.349551461245548 0.254775920686537 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WDR17 -0.0436736886049443 0.913597066190333 0.97241584900996 0.0521928937327546 0.897060678462024 0.967531580672392 False False False False False False False 0 insufficient_or_context_specific +RPL23 -0.0282687346950663 0.913683303606741 0.97241584900996 -0.0670227242925012 0.798523794960808 0.92925379048471 False False False False False False False 0 insufficient_or_context_specific +FMR1 -0.0204529387952451 0.913984181439485 0.97257054904637 -0.17146784512187 0.367966346936716 0.708317354196916 0.307587913416761 0.306685079177996 -0.478594569503164 0.0736734941147535 -0.171006656086403 0.550605669572177 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ASB8 0.0315210781826895 0.914171739459159 0.972594365911852 0.08962970461015 0.757792309211152 0.914687458631684 0.50959702600414 1.0 -0.439849544114373 0.172939598720099 0.593728672896315 0.0446307937900315 0.153879128781942 0.616827189672714 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WFS1 -0.0375845519367697 0.914346266078486 0.972619600287094 -0.344821489033059 0.306094926748496 0.661696690217148 -0.24719693415782 0.473752716687476 0.126398362929963 0.663820350161012 -0.120798571227858 0.709907780430773 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MT2A -0.0361831282865475 0.914576236490566 0.972619600287094 -0.103009939152826 0.759310503542415 0.915406319729464 0.14347315005272 1.0 False False False False False False False 0 insufficient_or_context_specific +ZFAS1 0.0370941652805999 0.914629885485337 0.972619600287094 0.221940857498873 0.525789081307376 0.804676662787375 0.121552094332305 1.0 True False False False False False False 0 insufficient_or_context_specific +LRP4 0.0372830546400686 0.914649023032826 0.972619600287094 -0.0399421415982151 0.906813399788168 0.971204694153325 0.258263914599528 1.0 -0.181773462132374 0.687653063957306 0.358338452267474 0.286737720129249 0.1765649901351 0.649846431519055 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AQP3 0.0597966815723119 0.914675128930721 0.972619600287094 0.973523650395783 0.13431233462603 0.520900171021663 True False False False False False False 0 insufficient_or_context_specific +USP20 -0.0170841333165893 0.914880443647125 0.97264130101151 0.0713204880304466 0.665469778825051 0.875081569913425 0.484283587069441 0.202559296088674 -0.445444938884861 0.156409882047757 0.0388386481845802 0.927177905708643 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MVP 0.0217977521237231 0.914901056918225 0.97264130101151 0.227535063797129 0.252328025652458 0.618991529980024 0.579476479696953 1.0 -0.369727898761822 0.226047130314307 -0.0972941834741835 0.732889590940263 -0.467022082236006 0.104569206472568 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CEP85L 0.0212826687094013 0.915012233689672 0.97264130101151 0.239430794484464 0.228780243149804 0.600424738880655 -0.260135763902545 0.647748496092696 0.375810192304115 0.394702111688424 0.11567442840157 0.826040869203951 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ASPA 0.029528446055034 0.915064031345646 0.97264130101151 0.176706453168001 0.527786364605283 0.805371937780399 -0.0001323828189407 0.999592852268872 0.713079781549842 0.1047863039189 0.712947398730901 0.156885480353538 partial_or_other True False False False False False False 0 cross_species_direction_conflict +STOX1 -0.0680044644417343 0.915242569968238 0.972733144123682 -0.634426823904594 0.304969929688273 0.661381253594365 False False False False False False False 0 insufficient_or_context_specific +SARS -0.0280447960044014 0.915443315086938 0.972848567759224 -0.314520535738397 0.199369939962536 0.575122356864606 -0.233203146020808 0.495330805341603 -0.200758283743749 0.480180558395696 -0.433961429764558 0.150412759690638 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPL1 0.0281223498617499 0.915608012634776 0.972898469030978 0.320708100001728 0.222385704522724 0.593397884800048 True False False False False False False 0 insufficient_or_context_specific +MMAA 0.0315599817360811 0.915674567793221 0.972898469030978 0.301036674156884 0.3221382922829 0.672877524535327 -0.601176144199791 0.212121774977215 0.0552917385830285 0.909348068162619 -0.545884405616763 0.218502129924389 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC005833.2 0.0398165883372869 0.916034489945288 0.973181851556645 0.248904732594051 0.512545434926982 0.797722104677086 True False False False False False False 0 insufficient_or_context_specific +VWA8 -0.0158355735728065 0.916303118496519 0.973181851556645 0.0505663197986865 0.731598952372148 0.904431845923655 -0.140618267616051 0.755658401102719 0.492498431918429 0.144654541856539 0.351880164302378 0.319728663750221 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIF1B 0.0148099707099565 0.916325251290898 0.973181851556645 -0.0235090066412414 0.865027184182147 0.958391272020028 0.4021741165173061 1.0 -0.0968309670402734 0.751798143959638 0.21940673730065 0.336238944439673 0.122575770260377 0.631467117878547 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SOCS3 -0.0552741760224376 0.916327937687889 0.973181851556645 -0.304443987128126 0.550632453382708 0.817317228007118 0.627837625196818 0.491931526685952 2.0 -0.62750310334036 0.232095501062957 0.161850486118084 0.737516725157156 -0.465652617222276 0.331975067409371 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UTY 0.115121276270188 0.916728415735129 0.973181851556645 -0.561367454870281 0.610679201042447 0.848390744855719 -0.0526148435947722 0.888246105077982 -0.370974722320576 0.153093860561081 -0.423589565915348 0.130212706439522 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLD5 0.0612704553501065 0.916957513251381 0.973181851556645 0.24206246390859 0.681064456412136 0.881267259952508 True False False False False False False 0 insufficient_or_context_specific +PRTFDC1 -0.041552185226558 0.917314435214671 0.973181851556645 0.120332806454546 0.766163940750228 0.919222600731922 0.0680252527558536 1.0 False False False False False False False 0 insufficient_or_context_specific +HTRA3 -0.0581382556824581 0.917401288889381 0.973181851556645 -0.0316220752516694 0.955762979388203 0.987410276805219 0.551068713909845 1.0 -0.606376809061245 0.232962905956415 1.10899990293466 0.0226708517766656 0.502623093873419 0.270132665736017 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NIPAL1 -0.0494288643241193 0.917554531008427 0.973181851556645 -0.728151661714593 0.122047448282259 0.5038394341269 0.210127541997393 0.859070568791721 -0.576334934357115 0.454358162554526 -0.366207392359723 0.71714751529154 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IQGAP1 -0.0174805687935428 0.917636092163053 0.973181851556645 0.143380249020133 0.368302486377646 0.708423693054324 0.352999213295873 0.260591734055747 -0.348771897719475 0.199364508619431 0.0042273155763984 0.990498624561998 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PARP6 -0.0198325096315542 0.917645568041255 0.973181851556645 0.03992994503933 0.832406867742405 0.944822630093409 0.175997091076775 0.701900310153983 -0.588390663554755 0.101370082051278 -0.412393572477979 0.284956544298373 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HHIP -0.0622590882675357 0.917870959036195 0.973181851556645 -0.0847888501277825 0.888485043812857 0.964276699808303 -2.55665191139222 0.0003879538647723 2.24303114539723 0.0012440564195057 -0.31362076599499 0.471522829714684 reversed False False False False False False False 0 insufficient_or_context_specific +H3F3A -0.0219609911335511 0.917905068502439 0.973181851556645 -0.184939015549454 0.364491146706419 0.705850610221272 0.0827774768380424 0.823402231275002 -0.112458962014457 0.688622868742973 -0.0296814851764149 0.927837341033715 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CHRNA4 -0.0835942877276581 0.918295688099519 0.973181851556645 0.577895699727523 0.505392931935415 0.792858629327505 False False False False False False False 0 insufficient_or_context_specific +GFPT1 -0.0236503532461244 0.918336506571839 0.973181851556645 0.180105043173221 0.42649025109801 0.747171397205924 1.43322763012991 1.0 -0.355311071256345 0.236958902692724 -0.0016685905331723 0.996186827773245 -0.356979661789517 0.196564223622268 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTSS1 -0.0251462177581987 0.918503578051944 0.973181851556645 0.123937772941678 0.617437696961558 0.85250682148546 0.189317004923432 1.0 -0.078947623029785 0.85705584996094 -0.164071507304066 0.605258176863272 -0.243019130333851 0.456375665965167 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UHRF1BP1 -0.0170376443510943 0.918590181688711 0.973181851556645 0.13705555182314 0.407100585149078 0.733976772200131 -0.47080160299757 0.198871127019193 -0.0273071112761984 0.9410458851919 -0.498108714273769 0.145119974783841 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FER -0.0227477750702007 0.918676488828983 0.973181851556645 0.142855890669023 0.518577133154636 0.800840369846825 -0.0681048628573087 0.845744671497688 -0.520277382346047 0.0475695868655829 -0.588382245203355 0.0379952264461362 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDE8B -0.0571084252650676 0.918721307140848 0.973181851556645 -0.848741727780359 0.0942365921208275 0.474102577239623 0.7436393871240741 1.0 -0.853717299910599 0.0976251205021661 0.341854981548299 0.447113492752957 -0.5118623183623 0.272743866507785 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DHX8 0.0262153100618606 0.918732079551898 0.973181851556645 -0.113253495838093 0.656186296439712 0.871684912617742 0.613954836326734 1.0 -0.399642610291825 0.173743749334662 0.191473778114976 0.451413362590521 -0.208168832176849 0.442967053498642 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FBH1 0.0131520905796882 0.918798702056889 0.973181851556645 -0.141509395597824 0.237586471077883 0.605329180588419 0.151129401511371 0.621154857208238 -0.535392899701131 0.0413758248316182 -0.384263498189759 0.141352743597743 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC092422.1 0.0729939049573254 0.919179206065809 0.973291952426317 -0.112794121908203 0.877079711117726 0.960989240400635 False False False False False False False 0 insufficient_or_context_specific +TAPBP 0.0168863970236818 0.919712414182783 0.973564434679608 0.159562964867086 0.325433617442349 0.674724889947951 0.341132143031004 1.0 -0.384561570291125 0.171725416470361 0.0214099647013991 0.9410458851919 -0.363151605589726 0.163565371504678 partial_or_other True False False False False False False 0 cross_species_direction_conflict +IL17RB -0.0717203192638101 0.919768016880408 0.973564434679608 0.0688306922312718 0.917570473527714 0.975930957742715 0.560897164408093 0.239259200695745 -0.743796178679309 0.066839602848813 -0.182899014271216 0.715773571981453 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RALY -0.0174189436345599 0.919805383209802 0.973564434679608 0.0839214820630749 0.631557167778987 0.860051667407526 -0.0610111843072102 0.850539759003816 0.226326393411348 0.315766779122604 0.165315209104138 0.496811243250859 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATP1A1 0.0276437533028418 0.919949412339927 0.97358645511841 -0.127243749702712 0.659922714259393 0.872407073022888 1.9959342741979 1.0 0.007445071794708 0.98828196103135 0.306769517941172 0.355113076188798 0.31421458973588 0.366290580919471 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM9B -0.0789593831684405 0.920250151846185 0.97358645511841 -0.381716130212453 0.622019943017459 0.854851430443277 False False False False False False False 0 insufficient_or_context_specific +ZNF594 -0.0284834518559135 0.920296574906713 0.97358645511841 0.0985978896415033 0.726944062599103 0.903365569206837 False False False False False False False 0 insufficient_or_context_specific +SLCO3A1 -0.0354072394139256 0.920411900865657 0.97358645511841 0.21281305068473 0.541263936264691 0.813591207158686 0.34241208540775 1.0 -0.0102227191529084 0.981042666510428 0.0610851701244321 0.848959291675689 0.0508624509715236 0.885169880040828 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLCO1B1 0.0427397593369569 0.920429233999169 0.97358645511841 0.0096717682483044 0.981862116309337 0.99451887511202 True False False False False False False 0 insufficient_or_context_specific +ALPK3 -0.0588363664675891 0.920438782585439 0.97358645511841 -0.278701804887799 0.616029179274615 0.851916120639411 False False False False False False False 0 insufficient_or_context_specific +METTL25 -0.0241302326694328 0.920471679768135 0.97358645511841 0.0990053109637936 0.682818483010338 0.882074824865184 -0.508561191846012 0.306685079177996 -0.0604975351337449 0.902366950975439 -0.569058726979757 0.211236293049119 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL136317.2 -0.0787053205171899 0.92081630868986 0.973786748521064 -0.340599506431413 0.661739615688761 0.87300348149968 False False False False False False False 0 insufficient_or_context_specific +POLI 0.0183126779398382 0.920845510251402 0.973786748521064 0.0843612650262535 0.651361606373513 0.870075384626967 -0.113718046704671 0.889856974423934 0.0912960140391075 0.880643525555888 -0.0224220326655637 0.975532414053379 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TTC9C -0.0229615703854519 0.921672695676792 0.974045030323348 0.154535803042959 0.516368498008523 0.799726369818831 0.185932962845407 0.645610418406442 -0.68391947869112 0.0441052079700082 -0.497986515845713 0.149204456597798 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CAMSAP2 -0.0162859128586257 0.921949312694656 0.974045030323348 0.164919816157984 0.321064191067875 0.672472248121257 0.0839354858171445 0.831512232858911 0.226307185168324 0.394097571844776 0.310242670985468 0.288420638167096 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HIVEP1 0.0216975840413619 0.922068901515344 0.974045030323348 0.230062367209532 0.280739338945325 0.642821222582925 0.0901184849941592 1.0 -0.182650024780822 0.555037174954294 0.279959495767997 0.246376203373713 0.0973094709871756 0.732945190435209 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TP63 0.0533083261055866 0.922126334883819 0.974045030323348 0.182490510479819 0.757491950488729 0.914454644719928 True False False False False False False 0 insufficient_or_context_specific +TFB2M 0.02954295204003 0.922212422135965 0.974045030323348 -0.117479196384465 0.691205054790717 0.885824849193387 0.200526603488508 0.608259596281419 0.256745469071807 0.372094808736335 0.457272072560314 0.1620055763325 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAFF 0.0616241087470069 0.922225560658094 0.974045030323348 -1.02343781174492 0.108379883472596 0.485070295736365 1.35257170694519 1.0 0.780569737173063 0.133086958437545 -0.327107131485226 0.41146746984608 0.453462605687837 0.357670588094286 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COX6C -0.0256217279712313 0.922317902435588 0.974045030323348 0.17180669282595 0.514194121699782 0.798491683514042 1.41007248004729 0.6637832878824721 2.0 -0.335190472492385 0.359385535310123 0.771774169895216 0.0247726766828159 0.436583697402831 0.181678224446525 partial_or_other False False False False False False False 0 insufficient_or_context_specific +REPS1 -0.0204536053313546 0.922449095530993 0.974045030323348 -0.130570700544076 0.525562606977016 0.804676662787375 0.498380889212995 0.0826549676755565 2.0 -0.190519043550629 0.579312487844748 -0.0668929170313398 0.822317515556986 -0.257411960581969 0.379756005764011 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RRM1 0.0253874961423521 0.922464891060347 0.974045030323348 -0.0601721458969621 0.819796379524695 0.937645994477492 1.52816442959847 0.0076290786814914 -1.19611012352248 0.0119325691705398 0.332054306075986 0.520691916165381 reversed False False False False False False False 0 insufficient_or_context_specific +AC010235.1 0.0569958076384643 0.922509415963176 0.974045030323348 -0.49844502950254 0.379925965161201 0.716424065042321 False False False False False False False 0 insufficient_or_context_specific +CYLD -0.0177229485006234 0.922553246256277 0.974045030323348 -0.0301924056421407 0.868380852103531 0.958502690861149 0.3066280675930431 1.0 -0.243103624220446 0.396911871643237 -0.0609413003790173 0.817759779332785 -0.304044924599463 0.236139292781148 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SYTL2 0.0417616097392228 0.922565855581879 0.974045030323348 -0.304575622881952 0.484090380246699 0.780666906162311 1.46158477316244 0.000396968660949 -1.18298796769121 0.0016281142477394 0.278596805471233 0.317456871148521 reversed False False False False False False False 0 insufficient_or_context_specific +TRMT2B 0.0266350061081366 0.922785540471276 0.974179555674006 -0.006254128411464 0.981810843176337 0.99451887511202 -0.254639732501581 0.485328813719358 0.0395698515732643 0.908298745225042 -0.215069880928317 0.508507845005585 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM217B 0.0351763219027254 0.923252734681851 0.974520391637577 -0.423629644937852 0.230949259502006 0.601518427890281 0.378806807957646 0.493408025677334 0.0911918327973857 0.840709977042864 0.469998640755032 0.326158399192308 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANP32A -0.0221559390666917 0.923292998442005 0.974520391637577 0.0965408580019395 0.683150707487785 0.882238818827245 -0.47709390656678 0.0887465062489926 -0.0363140135794369 0.900241012403475 -0.513407920146217 0.0586489351957818 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IL33 0.0470451644075179 0.923488396894373 0.974541702998348 -0.195629771331593 0.687673905129441 0.884451344908836 0.6170053157174821 0.5691361227005961 2.0 -0.457962653348192 0.455147427521776 -0.0559135092684269 0.923571415795912 -0.513876162616619 0.343401171080253 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PSMC4 -0.0392653952086606 0.92349779678902 0.974541702998348 -0.0262364960807931 0.949542163376788 0.986917609553614 -0.359601000445296 0.185874645503048 0.667834876865718 0.0142287523645604 0.308233876420423 0.214263482750879 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CPT2 0.0279435897292186 0.923803229354621 0.974683769539956 -0.0545516546602443 0.849931293411366 0.953127856970211 0.4748017362942479 0.355617457330047 2.0 -0.426342239528943 0.392184756924999 0.970013248905345 0.0339601769216508 0.543671009376402 0.217334618499353 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MTMR14 -0.01785362636096 0.924021583347812 0.974699844749433 -0.0702243197868206 0.702845405049265 0.891640364000942 0.298399684758492 1.0 -0.234597330478708 0.511969476012324 -0.241863090025225 0.407052257143167 -0.476460420503933 0.132294816413947 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HNRNPL -0.0139428618085601 0.92428110342272 0.974740640447832 0.0657694661794781 0.648056383242281 0.86855377695836 0.15129597164242 0.323151190699828 2.0 0.205552561305421 0.426758349452658 -0.192026501739122 0.375011106351808 0.0135260595662992 0.9604205391 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OTUD3 -0.0275218104354672 0.92457633856859 0.974777558628637 -0.069476909052784 0.811094966377903 0.933559430395498 -0.107564672696261 0.869189748977706 0.260011921255709 0.542305233977258 0.152447248559448 0.770196360085056 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CREB3L2 0.0305102524190238 0.924581458035482 0.974777558628637 -0.0834444821759328 0.796109173313992 0.928812397200087 1.31128293105132 0.117685624834572 2.0 -0.0664371397917777 0.85705584996094 0.0562474203275235 0.844270650188955 -0.0101897194642542 0.975532414053379 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GEMIN5 -0.026452446850862 0.924644558596874 0.974777558628637 0.165473330100308 0.563885062724734 0.823754286312897 0.28818273754294 0.403009386393767 -0.38815630184233 0.163222394482399 -0.0999735642993902 0.774204122542806 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC010542.3 -0.0316813378878573 0.924981917245906 0.97503585086684 -0.19293827395989 0.546364982177661 0.81552807024429 False False False False False False False 0 insufficient_or_context_specific +MAN1A1 -0.0235205286308843 0.925223863471413 0.975193526058818 0.165935814295836 0.495226469467405 0.787761581375387 0.533567643513579 1.0 False False False False False False False 0 insufficient_or_context_specific +YIPF6 -0.0151345567174584 0.925388375240879 0.975237522515469 0.226683126991346 0.19253615711144 0.570885363891703 -0.0117759394877456 0.983868445700542 0.207047418753989 0.587213233244138 0.195271479266243 0.654964322503747 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INSIG2 -0.021144768234987 0.925542714112995 0.975237522515469 -0.042851801967813 0.849902569188315 0.953127856970211 0.13085354382595 0.4931374504417921 2.0 -0.968602757408456 0.112962698356834 1.06144660543966 0.0592868602949863 0.0928438480312033 0.885169880040828 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FHOD1 -0.0222788812095972 0.925810258507996 0.975414472477699 0.0800409383605021 0.742648553336115 0.909193347184915 0.28715995292053 1.0 -0.255089925569227 0.519012541492431 -0.273088314945675 0.405938213169496 -0.528178240514903 0.127522222866515 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TLK1 0.0173033558654345 0.925895419887431 0.975414472477699 0.149382305655414 0.412052839039927 0.735291083225579 0.0949710260461247 0.0850748451605044 2.0 -0.198086485164902 0.482181300221052 0.217004277432151 0.343728677473234 0.018917792267249 0.947314545737698 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC00667 -0.0241681623175036 0.926680957751679 0.976144622562329 -0.238037748180498 0.362028465654152 0.703533322359016 False False False False False False False 0 insufficient_or_context_specific +RETREG1 0.0477880761571139 0.926872960258961 0.976249472706915 0.286958905331154 0.583756173051097 0.834132995585234 0.3524229486260539 1.0 -1.33992810130269 0.0234923823789317 1.4404008676145 0.011607751173525 0.100472766311814 0.857978393404808 reversed True False False False False False False 0 cross_species_direction_conflict +CDC14A -0.0290658289689939 0.92698780111688 0.97627303782464 0.0368430930609962 0.908196471492021 0.971404958566788 0.767870817365344 0.175144956637759 0.0361931049608433 0.940311244788927 0.804063922326187 0.127369691583538 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COL4A3 0.0252753237618181 0.927323561519845 0.976485995820212 0.134125873361648 0.628778274562471 0.858472266510466 0.0927905840645494 1.0 -0.43329793231505 0.495330805341603 -0.729911346946125 0.18313142943814 -1.16320927926117 0.0615767601338601 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AC092835.1 0.0209449142038697 0.927374983906921 0.976485995820212 0.291684448986899 0.220113855392757 0.59217704709374 True False False False False False False 0 insufficient_or_context_specific +ZNF717 -0.0201307707500291 0.92764369803344 0.976653449171272 0.204774752714804 0.344744185318677 0.69073818751447 False False False False False False False 0 insufficient_or_context_specific +SUZ12 -0.0185851013281012 0.927719022706827 0.976653449171272 0.102735825614121 0.618681613351051 0.853546133343446 0.654349276881562 1.0 0.446131543927575 0.208648153678993 -0.178120084696573 0.549348188433042 0.268011459231002 0.419559727499062 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBE2E3 0.0185809906472682 0.927856231332956 0.976700507518778 0.165182032938133 0.420806387311882 0.742471251256147 -0.22267424999168 0.381059669821075 0.0180817497254109 0.942395283913998 -0.204592500266269 0.37135754729829 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AKR1C3 0.0263607041160993 0.928154320877543 0.976916889624673 0.218474037045496 0.452878055014307 0.76491545430188 True False False False False False False 0 insufficient_or_context_specific +ARFIP2 -0.0261962451291003 0.929113360064336 0.977594884193597 0.150460746556461 0.609594799012197 0.848013066172034 -0.213491984331889 0.481511780387807 -0.497348853216345 0.0616215833826196 -0.710840837548234 0.0206212459289334 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GMPS 0.0205650918657086 0.929154228412775 0.977594884193597 0.234149413916548 0.304647055221908 0.661341495477036 -0.241875740413389 0.511728206818558 -0.0682812805156027 0.83894338614294 -0.310157020928991 0.331857423784009 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MAP3K10 -0.0217835863505356 0.929261437560801 0.977594884193597 0.106832268222545 0.666380527757506 0.87511808324756 0.261320323311046 0.410228637028959 -0.437718766722705 0.101995886036925 -0.176398443411659 0.553728730290258 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC00886 -0.0377048291377343 0.929704720280337 0.97796377769451 -0.259357859888664 0.544053786068858 0.814999982025397 False False False False False False False 0 insufficient_or_context_specific +JAKMIP3 0.0393095371064123 0.929871224392699 0.978041481085686 -0.17902654346177 0.697870884593358 0.889035426303613 False False False False False False False 0 insufficient_or_context_specific +INTS6 -0.0189566343694535 0.93019267638089 0.978086221156897 0.298780392648344 0.161985129313951 0.543541307772207 0.354129772681486 1.0 0.199134574712649 0.567415141544302 -0.478986675025327 0.0939641184674323 -0.279852100312679 0.351430376517966 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SNX10 -0.0465908111241089 0.930207340537739 0.978086221156897 -0.291979183213483 0.571049585601426 0.826815897528779 -0.214358336479808 0.599273273597044 -0.0799510917774997 0.816723102809629 -0.294309428257308 0.398065229205286 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HNRNPA1 0.0157345949330547 0.930311176053367 0.978086221156897 -0.0543922293839069 0.764175451605029 0.917149530299636 0.814423808551344 0.0305302562938069 -0.246746253487582 0.40601973924532 0.567677555063761 0.100181556652157 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC009403.1 -0.0247790088021419 0.930363335933333 0.978086221156897 -0.0082272527471169 0.976678100732757 0.992970766113577 False False False False False False False 0 insufficient_or_context_specific +TK2 0.02590922014427 0.930448582890216 0.978086221156897 -0.0887809633259598 0.763402081560303 0.916866798061945 0.7680881065297142 1.0 -0.294497679033684 0.367294583103341 0.120359917451261 0.674608220210568 -0.174137761582423 0.567288813400829 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TOPBP1 0.0154335936773399 0.930670313417375 0.978105499738451 -0.0215256935660574 0.903127673063526 0.969420696645456 0.732452429552937 0.0810931983929462 -0.575771888513886 0.0973025259289476 0.156680541039051 0.716715375441809 reversed False False False False False False False 0 insufficient_or_context_specific +CHST3 0.0260778935935872 0.930673219395006 0.978105499738451 -0.405155612706424 0.150783771791977 0.53368255534016 0.8582050724783349 0.3198957111815611 2.0 False False False False False False False 0 insufficient_or_context_specific +TTC36 0.0488122122382218 0.931236141110938 0.978414772811678 0.291377087471269 0.635625840772911 0.861898723009269 True False False False False False False 0 insufficient_or_context_specific +STAC -0.0488217232787195 0.931245505965576 0.978414772811678 -0.407610925220374 0.471735094513815 0.775037912267227 1.14960555515944 1.0 False False False False False False False 0 insufficient_or_context_specific +ATP5F1B -0.0205274832641809 0.931400837133771 0.978480600841627 0.0864347387915078 0.712269741510317 0.895497343705388 0.0692288314823784 1.0 False False False False False False False 0 insufficient_or_context_specific +ZNF718 -0.0148731093427267 0.931577142096405 0.978526115491437 -0.0069209752070638 0.968002617901709 0.991065707083724 False False False False False False False 0 insufficient_or_context_specific +TM9SF4 0.0123323663424238 0.931722204871701 0.978526115491437 0.0086199781633099 0.952115742382011 0.986925850408325 -0.0855763565075278 0.831717386516092 0.0492776232241218 0.877080762020419 -0.036298733283406 0.918258746367039 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RRP8 -0.0314975071880303 0.931940613814751 0.9786581460768 -0.116025364150981 0.747303482129271 0.909830759894547 False False False False False False False 0 insufficient_or_context_specific +RPP30 -0.0210179348060493 0.93320297005146 0.979788878063178 0.0356797611075572 0.886644569927695 0.963622568156774 0.506074771652221 0.301348543317779 -0.11036108752169 0.785306446349907 0.395713684130531 0.379502832647405 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SDS -0.0905496468521612 0.93344682777262 0.979846555715671 -0.156864328237143 0.885028250828283 0.963081098449005 -0.822402682677636 0.0278970866656539 0.760386957472815 0.0287140062181942 -0.0620157252048211 0.870298642859208 reversed False False False False False False False 0 insufficient_or_context_specific +VRK3 0.0184662552556207 0.933536323540816 0.979846555715671 -0.320361965863273 0.149859180719567 0.533583468169136 0.273372246422126 1.0 -0.156036636437251 0.597729445027495 0.220388950414434 0.344415684028194 0.0643523139771829 0.818096459903184 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF195 0.0172652670397516 0.933754670304589 0.979978311041337 0.0622518371907751 0.76337619958969 0.916866798061945 True False False False False False False 0 insufficient_or_context_specific +SZRD1 -0.0230771635979062 0.934134062068098 0.980163557958309 -0.225566667986339 0.398772432512936 0.728959004281672 1.1800478297773 0.899303979049325 2.0 -0.156136454135451 0.655914000308081 0.0340455665110701 0.91598523904523 -0.12209088762438 0.695756242028843 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PURA 0.0160099471087312 0.934250054077701 0.980163557958309 0.0799025668542444 0.677855528957163 0.879886294337383 -0.115951786925113 0.687173949044121 -0.119599573676184 0.604925864039319 -0.235551360601297 0.318269438599264 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ZNF707 0.0300244755745115 0.934395359997194 0.980163557958309 -0.106303887185283 0.788287802759443 0.926576536501901 False False False False False False False 0 insufficient_or_context_specific +GALNT7 -0.0221177548972182 0.934722324611622 0.980309692427196 0.147297430880451 0.586558014233739 0.835274227991216 0.158606618780411 0.751798143959638 0.0228303629341587 0.954602461935602 0.18143698171457 0.668655303778611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LEO1 0.0177712120448625 0.934923239157966 0.980309692427196 -0.0211204055392537 0.925659556532258 0.978485542437683 -0.162340469615294 0.701769001297478 0.42868061002123 0.178281192311464 0.266340140405936 0.439197180170047 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HNRNPR -0.0149866895317071 0.935086562056265 0.980309692427196 0.149855762004988 0.412806559032945 0.735472772573377 0.348360533504637 0.589874038415162 2.0 -0.0881326620153601 0.812823453165789 -0.365567596862229 0.174015474474831 -0.453700258877589 0.116432079776311 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GNL1 -0.0173716767364511 0.935104555549673 0.980309692427196 -0.177615754419292 0.375806589585941 0.7132826228158 0.174436693286205 0.482181300221052 -0.573502028929253 0.015199749014023 -0.399065335643047 0.0796596157058865 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UAP1L1 -0.0319149581223028 0.935217288995437 0.980309692427196 0.0871992610904767 0.82751366901387 0.942259214105446 0.3543795642368179 1.0 0.512004383991097 0.0531057362102515 -0.8626618642803 0.0037657511711964 -0.350657480289203 0.159057706726719 reversed False False False False False False False 0 insufficient_or_context_specific +NCALD 0.0224442723587543 0.935287422417164 0.980309692427196 0.0919399451912223 0.738782843435118 0.907558041400239 0.479449271327831 1.0 -0.267696953444862 0.449128186223336 0.392448573411709 0.166192643274619 0.124751619966847 0.705831888568513 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL034417.3 0.0630072677117517 0.935353552639168 0.980309692427196 -0.524936477685296 0.500782319144069 0.790819493321426 False False False False False False False 0 insufficient_or_context_specific +SGPL1 0.0133454868526701 0.935370320279558 0.980309692427196 0.220374756613401 0.151552549280331 0.534332907346501 0.332074250275883 1.0 -0.116128755374207 0.766314190681721 -0.210559717956181 0.472800105141782 -0.326688473330388 0.290169336590595 partial_or_other True False False False False False False 0 cross_species_direction_conflict +NSF -0.0211587283845377 0.935493397111768 0.980341368407548 0.0168653959476847 0.948573225586936 0.986642915209573 -0.156066286387688 0.67316207619795 -0.139564580945183 0.633690597456881 -0.295630867332871 0.332164660213055 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NMD3 0.0214075679726363 0.935801015186316 0.98049371749989 0.334295934747737 0.194471376378879 0.571343735852293 0.157509922875222 0.0863493595600329 2.0 -0.415026581548115 0.298006594081837 0.393716150250995 0.230552786272591 -0.0213104312971196 0.959339925271389 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AHCYL2 -0.013671079749689 0.936340159702486 0.980839773674307 0.0392648184585095 0.816254596145392 0.936230700610385 -0.505530506010338 0.12717527440867 0.653792736712201 0.0309537403591194 0.148262230701863 0.636594114880455 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SP4 0.0184620542646821 0.936574137263393 0.980987077502669 0.157801585738377 0.49674215539241 0.788899470010991 -0.475210789250849 0.252985951402955 0.42290407723927 0.22206294057312 -0.0523067120115791 0.90503233371914 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SH3BP5L 0.0194198501918833 0.936744334127981 0.981043634740153 -0.134565867707802 0.575501765741678 0.829928048970172 -0.144593159375434 0.688166341999004 -0.430132484898989 0.128732653862785 -0.574725644274423 0.066217732193862 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC007220.1 0.0338861227293195 0.936999811774929 0.981043634740153 -0.322352892872906 0.473004095010423 0.77582371215163 False False False False False False False 0 insufficient_or_context_specific +NCBP1 -0.0183809074257793 0.937376089099388 0.981165178685723 0.118621415589147 0.604973213074755 0.846449401489963 0.123543359759415 0.666961519675965 0.0426177932578973 0.861675991584133 0.166161153017312 0.489665210609698 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ICA1L 0.0231077067165759 0.937530821197976 0.981165178685723 0.0956235516885353 0.746321556565709 0.909830759894547 True False False False False False False 0 insufficient_or_context_specific +LYSMD3 -0.0274360835304005 0.937567867604461 0.981165178685723 0.179289858723369 0.608820719359535 0.848011761873084 -0.183393382607563 0.520117206758628 -0.11493951505401 0.63342866570884 -0.298332897661573 0.226231352970303 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OPN3 0.025331537401121 0.937580553870076 0.981165178685723 0.159835471725785 0.624957635290653 0.856338486330344 True False False False False False False 0 insufficient_or_context_specific +PRPF6 0.0130514276588404 0.937711974503504 0.981184143218701 -0.143920951186834 0.385799010075357 0.720039941378048 -0.511782535682561 0.056881626542323 0.174420764033478 0.453276171857452 -0.337361771649083 0.166576239234014 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EXOC6 -0.0154178771709219 0.937784541505959 0.981184143218701 0.0389274858126088 0.844325907670558 0.950868579539813 -0.528051787708617 0.236644723150733 0.556276184795493 0.136812181134885 0.028224397086876 0.951263780050994 partial_or_other False False False False False False False 0 insufficient_or_context_specific +THAP4 -0.0254363564623327 0.938145591739579 0.981464641060888 -0.168529200891892 0.606601401286146 0.846931578987574 0.350448518362434 1.0 -0.216519048980377 0.581957554140596 0.270094707846231 0.366683355644107 0.0535756588658541 0.889065524481604 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACTN1 0.0296560375208825 0.938338570514396 0.981523830852334 -0.326416707743412 0.401730992394221 0.730970076414215 0.3837353662031721 1.36241922743598 2.0 1.03651166101344 0.0203718553552959 -0.694123658969435 0.0688639416647823 0.342388002044008 0.381203194716467 reversed False False False False False False False 0 insufficient_or_context_specific +NNT-AS1 -0.0179817395111882 0.938455064090609 0.981523830852334 -0.0117623942348042 0.959635896524064 0.988617762369409 False False False False False False False 0 insufficient_or_context_specific +DGCR2 0.0124092772043679 0.938536622391663 0.981523830852334 0.0723136261281866 0.655961793052169 0.871684912617742 -0.366040408897991 0.159281213122293 0.32187047199664 0.158702518928294 -0.0441699369013509 0.873756844967821 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MTFR1 -0.0151831950953784 0.938574028820342 0.981523830852334 0.060407051591506 0.759699815198072 0.915406319729464 0.0575052773879869 1.0 -0.353364633152443 0.254771541846249 0.306428899731769 0.253169622819798 -0.0469357334206743 0.887150677072413 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFXL1 0.0163339668761322 0.939209745085796 0.981907001675917 0.116973938315042 0.584595678350287 0.83427397074951 -0.181665986096392 0.570966174114907 -0.592210502164343 0.0367367524033114 -0.773876488260735 0.0170252923874991 partial_or_other True False False False False False False 0 cross_species_direction_conflict +EIF4A2 -0.0180442782854059 0.939298681640986 0.981907001675917 0.237793287639983 0.273741091466859 0.637441209463408 0.0661140910810519 1.0 0.0734728187295039 0.830481923943397 -0.104533523927366 0.68628852171258 -0.0310607051978616 0.918258746367039 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CD58 0.0212710534471189 0.939312437670653 0.981907001675917 0.307220187603799 0.262359309175473 0.625138701483784 True False False False False False False 0 insufficient_or_context_specific +UBASH3B -0.0244966939515072 0.939476929638477 0.981981726870907 0.19530968237971 0.542209435467691 0.814085213263351 1.04579990790307 1.0 0.321936562330308 0.610170802368897 -0.241727071895695 0.628416143991577 0.0802094904346134 0.898562836938941 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CBY1 -0.0164076611024176 0.939639696190913 0.982054633971854 -0.0334270341891781 0.876440214918584 0.960605213288009 0.275870838794644 0.538965126903979 -0.193180624289435 0.577616232440873 0.0826902145052095 0.853199381712967 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LGR4 -0.0158940219011626 0.93989681152453 0.982214456719523 -0.0403534036049946 0.848674980203572 0.953127856970211 -0.36757129597264 0.361820986612172 0.861219446976859 0.0197863226739372 0.493648151004218 0.162148425910995 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP3K8 0.0253647877842596 0.939978676898471 0.982214456719523 -0.125390206887245 0.715641124518418 0.897356174900886 0.427432474562828 1.15469014616801 2.0 -0.260449876803462 0.493127652902932 -0.544416424505445 0.0939502443951976 -0.804866301308907 0.0300534715352082 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TLCD2 0.0258293861042812 0.940112842003158 0.982224862335528 0.0245008763676079 0.943235661641426 0.984366565940656 -0.454569982633361 0.0939914368072628 0.646114334870665 0.0147363135885258 0.191544352237303 0.436245692082304 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TOMM20 -0.0218376012317137 0.940174697742266 0.982224862335528 0.116154884589637 0.688561078695068 0.884999569552245 0.541263879231126 0.258053402063943 -0.0183745249181519 0.967568471469058 0.522889354312974 0.232210953484197 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC004870.4 0.054458963259561 0.940383016221008 0.982264930847491 -0.0692335826463971 0.920710398937405 0.976409047961579 False False False False False False False 0 insufficient_or_context_specific +BMP2K -0.0115626199829379 0.940435533176725 0.982264930847491 0.135287587553781 0.389115588917898 0.722144909086864 0.511670076902041 0.174742904872154 -0.0885945603031505 0.793769370128773 0.42307551659889 0.224797984005561 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL139383.1 -0.025825117431268 0.94057006284688 0.982264930847491 0.134669604415407 0.689406590814436 0.885062595551899 False False False False False False False 0 insufficient_or_context_specific +VPS11 0.0184207115014608 0.940618850004419 0.982264930847491 -0.0967375267724518 0.689811285506571 0.885210584988815 -0.0916078725460417 0.742476681088267 -0.0588705643741551 0.794442764242641 -0.150478436920197 0.508507845005585 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF236-DT 0.0253428478473795 0.940680818907144 0.982264930847491 0.0224496191578236 0.947379866551238 0.986094250821001 True False False False False False False 0 insufficient_or_context_specific +MED14 -0.0107846615186711 0.940771261671702 0.982264930847491 -0.107524497155863 0.451334177269624 0.764202910889105 0.590527178675882 0.0282744990449832 -0.571812490522306 0.0198339650278164 0.0187146881535763 0.947534261417549 reversed False False False False False False False 0 insufficient_or_context_specific +CLK3 -0.0190185123177232 0.941022681722547 0.982378765197024 -0.10161513598261 0.686304054061267 0.883766093764954 0.311304236631961 1.0 -0.0601037228310327 0.842120288450274 -0.46629853233658 0.0415127576748528 -0.526402255167612 0.0328482704143711 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RHOU 0.038683446247402 0.941066379162976 0.982378765197024 -0.532099044364499 0.285269027355363 0.646324118201271 0.991030872454346 0.368697572934811 2.0 -0.555729371899928 0.117301937823458 0.270563447464401 0.385986481338582 -0.285165924435528 0.382330014536178 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF667 0.0312250716792392 0.941170835662364 0.9823906755238 -0.0166268216284665 0.967450988762926 0.991010724687976 False False False False False False False 0 insufficient_or_context_specific +SEC13 0.0169325433311448 0.941469548719787 0.982504875364752 0.0335895956389219 0.884117394821612 0.963081098449005 -0.0194387292348086 0.953173095923033 0.201592939267192 0.363250610358758 0.182154210032383 0.439665464839222 partial_or_other True False False False False False False 0 cross_species_direction_conflict +COL23A1 -0.0196134953847845 0.941791846245463 0.982504875364752 0.117255310958784 0.663962125029215 0.874384483010807 False False False False False False False 0 insufficient_or_context_specific +KIAA2013 0.0247597869507953 0.941814076068153 0.982504875364752 -0.231258058029025 0.493844727916274 0.786363265568912 False False False False False False False 0 insufficient_or_context_specific +TRA2A 0.0101150190264172 0.941827440992854 0.982504875364752 -0.129541579698593 0.345447561140593 0.691144142244059 0.085171213380367 0.821131429576911 -0.803221714511403 0.0122293965275112 -0.718050501131036 0.0260307101936817 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AJM1 0.029375329991595 0.941838590979983 0.982504875364752 -0.395372635066854 0.30044111619306 0.658632920234719 0.404655706880665 1.0 False False False False False False False 0 insufficient_or_context_specific +STPG2 -0.0252296767429676 0.941947289763477 0.982521190014107 0.0635472911051234 0.855038680785674 0.955391934779887 False False False False False False False 0 insufficient_or_context_specific +USP43 0.0600833996572227 0.942370156880297 0.982743640089234 -0.22896365760491 0.788567944016219 0.926576536501901 False False False False False False False 0 insufficient_or_context_specific +CYP46A1 -0.0315963642868899 0.942541843172543 0.982743640089234 -0.110438314349156 0.799833735988405 0.929755328734014 0.314692643341409 1.0 -0.147657059218899 0.842120288450274 -0.493070892223776 0.337441353499831 -0.640727951442674 0.262855407375883 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AP000487.1 -0.0187994318413688 0.942680577184977 0.982743640089234 0.216303975824992 0.412739171852144 0.735472772573377 False False False False False False False 0 insufficient_or_context_specific +GNA13 -0.0170058705224884 0.942781744865083 0.982743640089234 0.333498201732466 0.146153382366677 0.532796338690088 -0.27597169832634 0.326527528213087 -0.499184390510704 0.0545812887972066 -0.775156088837044 0.012540209536432 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AKIRIN2 0.0149258010562193 0.94278902325153 0.982743640089234 -0.16006795300677 0.435076243463344 0.752545048900064 0.0254405655881756 0.936257534403958 0.0224235606804216 0.928541937519275 0.0478641262685971 0.851394249900937 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCSER1 -0.028674745288541 0.942796905025393 0.982743640089234 0.0134094600962356 0.972263082975259 0.992040338141303 False False False False False False False 0 insufficient_or_context_specific +AGO3 -0.0115487307256513 0.942905197395714 0.982743640089234 0.0536676337359266 0.737653581520827 0.906758238874944 0.3679246094607589 1.0 0.0712125341090898 0.868900513081839 -0.137247164660903 0.657512059635847 -0.0660346305518134 0.856332495702401 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKS1A -0.025071773520315 0.94324309060776 0.982998771161458 -0.174771214563167 0.614472448719189 0.851167687428129 0.6732233612630231 1.14054568296619 2.0 False False False False False False False 0 insufficient_or_context_specific +ZNF521 0.0254982337873975 0.943373181404324 0.983016284553863 0.0840986980004 0.814151991872863 0.935446373946424 0.428835867588608 1.0 True False False False False False False 0 insufficient_or_context_specific +RAP2C-AS1 0.0184630479896308 0.943454062073262 0.983016284553863 0.179867617473931 0.481827520597638 0.780666906162311 True False False False False False False 0 insufficient_or_context_specific +LINC02193 0.0204560772341404 0.943539214592616 0.983016284553863 -0.0733877684451499 0.797820793539636 0.92925379048471 False False False False False False False 0 insufficient_or_context_specific +PLEKHM1 -0.0187315466509233 0.943725694601596 0.983063006405724 -0.188473617595298 0.460391448083855 0.768745132096508 -0.148644906813201 0.660616604299113 0.0872199028620947 0.751730765019143 -0.0614250039511067 0.846008780972659 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC092329.3 -0.034238871180331 0.943826817008531 0.983063006405724 -0.072406259748725 0.878657212307666 0.961432567887278 False False False False False False False 0 insufficient_or_context_specific +CTPS1 0.0350747623515073 0.943908108144455 0.983063006405724 -0.170019454433353 0.732547138290225 0.904431845923655 0.657128270131349 0.516010588955639 0.042461428718864 3.0 False False False False False False False 0 insufficient_or_context_specific +SPRYD7 -0.0138752009598645 0.943956503025311 0.983063006405724 -0.0590258173645439 0.763475478319971 0.916866798061945 -0.540066665348693 0.151095589621829 0.78530302528289 0.0230926151250407 0.245236359934197 0.466566447534186 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOL10 -0.0113841095985833 0.944406708335037 0.983216460436018 0.152683088388024 0.342471912014475 0.689130402583821 -0.0356542139409865 0.94271587087373 -0.715580948556052 0.0456085853791058 -0.751235162497039 0.0539916047406627 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NDUFS7 -0.0264622618575992 0.944422770164684 0.983216460436018 0.133930950675045 0.725544435579515 0.903230533056069 0.6363253362775539 0.501662334348537 2.0 -0.650323086603649 0.0627905904042908 1.01326576218327 0.0066271729098494 0.362942675579626 0.245693323860061 reversed False False False False False False False 0 insufficient_or_context_specific +TRIM22 0.0194133181209238 0.944655797479757 0.983306310735608 -0.13566885334849 0.626763559019595 0.857061216957504 False False False False False False False 0 insufficient_or_context_specific +KIAA1109 0.008563028749383 0.944818121952516 0.983378325273528 0.0162382246773592 0.894989174137912 0.96687769370184 True False False False False False False 0 insufficient_or_context_specific +HSPA5 0.0288826374189398 0.945022042229103 0.983493614771303 0.19821681018469 0.640938314246886 0.864685244290649 0.345127633027959 1.0 -0.645546661463706 0.229712771228116 0.906044433659267 0.0672837471707679 0.260497772195561 0.61396664458685 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RAPGEF1 -0.013892814099154 0.945502846879947 0.983695730520834 0.0193112865690847 0.92428103503432 0.978224179287905 0.6838938268965601 1.0 -0.440495309418209 0.0676736163476962 0.188271095731121 0.368137107073752 -0.252224213687087 0.251130851858594 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC113386.1 0.029700148371204 0.945554868739489 0.983695730520834 0.117195992229886 0.789468100906804 0.927187163688279 True False False False False False False 0 insufficient_or_context_specific +S100PBP 0.0098441102497909 0.945588934367867 0.983695730520834 -0.0061768957107745 0.965531643743753 0.990582362709799 0.285321774858855 0.562633030035581 -0.419596530667678 0.279403530922978 -0.134274755808823 0.776776906434958 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SSBP3 0.0190214466315498 0.945735977142116 0.983751768144479 -0.30942110159067 0.229809869609335 0.601091682478031 0.372263129466594 1.0 -0.355508629109427 0.149394353934129 0.61884508506988 0.0118160386707344 0.263336455960453 0.236623215181657 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC7A2 -0.0325243394669371 0.946253234479606 0.984036829029081 -0.174364574049422 0.716758927152499 0.897798167383567 0.215856612861272 1.0 -0.993547503755155 0.0322634458426057 0.814773187037921 0.0517748457352881 -0.178774316717234 0.684536453898523 reversed False False False False False False False 0 insufficient_or_context_specific +RHOB -0.0308073271720651 0.94628963109796 0.984036829029081 -0.556343764064761 0.20275221233212 0.57668584531318 1.06284584430325 1.0 -0.382720336346189 0.386178784252937 0.947283228795425 0.0249703669592252 0.564562892449236 0.155940091658023 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HDDC2 0.0172147303209931 0.946569434933098 0.984230854246962 0.328844703246012 0.199800427959464 0.575263953748573 0.496144343708504 1.0 -0.492115968877118 0.570591253420651 -0.211303148892012 0.77636917457778 -0.70341911776913 0.351313527679333 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TM2D1 -0.0109984808060418 0.946769633397994 0.984342076751947 -0.0727379817434193 0.657014007265208 0.871684912617742 1.10290347638787 1.0 0.280227883252261 0.40741549468231 -0.508854842195287 0.0757757064778855 -0.228626958943026 0.46503773726748 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MEGF8 -0.0154666450908686 0.946903409268901 0.984384225586949 -0.230296998325282 0.310812884940078 0.66386306487225 0.582893396615499 1.0 -0.114586723642081 0.754470480122763 -0.640403963882139 0.03389307203032 -0.75499068752422 0.023257696200555 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DPH6-DT -0.0232619670646459 0.947324832929665 0.984725370293532 0.0630933493041527 0.858276137942863 0.956914759994669 1.1564090462759 1.0 False False False False False False False 0 insufficient_or_context_specific +CRYBG1 -0.0294090982849284 0.947642579521492 0.984861733889941 0.0070689343726773 0.984661807730838 0.995028652950056 -0.809838100796359 0.21142777235682 0.649102974398914 0.230552786272591 -0.160735126397445 0.800098332000689 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBBP4 -0.0107181773656304 0.947748709677704 0.984875086296968 -0.159290815072489 0.322546323446069 0.672877524535327 -0.344537196952249 0.203349440931706 0.623650281744535 0.0195053385632711 0.279113084792286 0.260265783751745 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GPR75-ASB3 -0.0175877527676849 0.947908323730099 0.984929017995186 0.113183792802092 0.672936803249305 0.877361032137705 0.0226236774497863 1.0 False False False False False False False 0 insufficient_or_context_specific +PEX11B 0.0234282727710412 0.948024571057992 0.984929017995186 -0.069885278276606 0.849229970811688 0.953127856970211 0.295487259592202 1.0 0.351298024579949 0.325585045260735 -0.0358496927763358 0.91598523904523 0.315448331803613 0.332314924435221 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IL1RL2 -0.0342768748405523 0.948080470722209 0.984929017995186 -0.14287659578391 0.7784643913969 0.922929913000972 0.0615864387834941 0.336488783066831 2.0 0.656389931244184 0.438853076644795 -1.02065057358496 0.127284477362188 -0.364260642340776 0.686635350809716 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TOX2 0.0240142023232562 0.948387005661532 0.984984740237977 -0.0304278802011862 0.934603365147841 0.981436002157239 False False False False False False False 0 insufficient_or_context_specific +SLC9B1 -0.0189066480081149 0.948589731149816 0.985070363084465 -0.107133363935913 0.710447360224183 0.894668801198345 0.373526379076475 1.0 False False False False False False False 0 insufficient_or_context_specific +SLF1 0.011619043679389 0.948851479110371 0.985120542282947 -0.0843782852022045 0.636716500332587 0.862184533860645 0.353091320885387 0.532893532101164 -0.462813651394724 0.283796459494818 -0.109722330509337 0.848448333720257 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FASTKD2 -0.0200096038313119 0.948978544920882 0.985120542282947 -0.0542283263154354 0.860825742927759 0.957399999350182 0.0194989213286719 0.976941691142458 -0.149521431248066 0.744134314652532 -0.130022509919394 0.810246838060808 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EFNB1 -0.0248603189445727 0.949011274442115 0.985120542282947 -0.23678007252464 0.523404142732526 0.803562736508653 0.470134756156541 0.0674209734718208 -0.160300361009259 0.463530534137655 0.309834395147282 0.190549644935964 partial_or_other False False False False False False False 0 insufficient_or_context_specific +WASHC5 -0.0135745419510976 0.94916662609934 0.985122402301285 0.0169320048420535 0.937189421104587 0.98270832990396 0.173271036484543 0.689820350802268 -0.500961756850924 0.130367635754485 -0.327690720366382 0.372523556216188 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A15 0.0539734412611687 0.94919967783775 0.985122402301285 -0.0983658537933115 0.911839235961758 0.972709498713518 -0.890418521726487 0.0216988135609496 0.548979625828791 0.0975789966571976 -0.341438895897696 0.310129378501062 reversed False False False False False False False 0 insufficient_or_context_specific +ZNFX1 0.0122068480314196 0.94930327552993 0.98513308266611 -0.126413268535565 0.498913044994726 0.7899705952391 -0.0219154327033335 0.95965402085228 0.0390387024119327 0.908885884946928 0.0171232697085992 0.963592920213227 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LYRM4 0.016880040593002 0.949678390795155 0.985323392859674 0.0828744236097513 0.753765801556502 0.913602082065829 -0.26077267146106 0.661386573767127 0.457813808588861 0.283105821907691 0.197041137127801 0.701386934013348 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SNRK -0.0095312947654924 0.949705200570817 0.985323392859674 -0.0921089635353476 0.53416576297072 0.810537816246747 -0.417296373815927 0.25733954313929 0.37376164982532 0.238306783981868 -0.0435347239906071 0.912491421579475 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRICKLE2 -0.0134852315992782 0.950208000569408 0.985661698394014 -0.155351186551877 0.468062995262497 0.772583012794147 0.580593673781927 0.849442628954467 2.0 0.0584491907245102 0.869015643979454 -0.384436081767325 0.123828264840496 -0.325986891042815 0.217301995180089 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HMGCLL1 0.0240853779404155 0.950279449512471 0.985661698394014 -0.0943819530083281 0.806788896339515 0.932788199072101 False False False False False False False 0 insufficient_or_context_specific +ZNF277 0.0107921509855034 0.950439990883599 0.985693719661144 0.195143411625955 0.253567350180336 0.618991529980024 True False False False False False False 0 insufficient_or_context_specific +LINC00278 -0.0590346431393456 0.950497041093967 0.985693719661144 -0.30843403593769 0.745389445217512 0.909500945159707 False False False False False False False 0 insufficient_or_context_specific +LPGAT1 -0.0088975367968134 0.950731897463337 0.98584044130995 0.0751280326547958 0.593332958926646 0.839379713709982 -0.410663629947217 0.0865057025048686 0.466359040420265 0.0388325156710579 0.0556954104730473 0.821178948278722 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NEIL1 0.0177632127007579 0.950852592270555 0.985868768456498 -0.125986166717284 0.656473238377366 0.871684912617742 0.649068952219376 0.171394020011477 -0.96335184085444 0.0277273730893098 -0.314282888635063 0.511323573569385 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PDSS2 -0.0097931581002991 0.951225790765627 0.98602199054023 0.022178966472748 0.889034339719007 0.964276699808303 0.0804326913081394 0.90352186178017 0.16950949814819 0.700043498049031 0.24994218945633 0.613631873014617 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADGRE5 -0.0296467949076851 0.951312914474397 0.98602199054023 -0.303023480786529 0.537312636238631 0.812087893451657 0.9407968130449441 1.0 0.496936058729598 0.153524770712625 -0.171988993145896 0.578630557136629 0.324947065583701 0.312381245505633 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCNB1 0.0415518629844551 0.951373936127422 0.98602199054023 0.0071348455365946 0.989439174897878 0.996896452948454 0.833839755633519 1.0 -0.0518586107173408 0.940538062120283 -0.200376618788084 0.659510059224109 -0.252235229505425 0.6351603677909 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AL162231.2 0.0167925499912131 0.951591832221778 0.9860827708185 0.0660805463128584 0.807804376477432 0.932788199072101 True False False False False False False 0 insufficient_or_context_specific +PRCC 0.0086047576026083 0.95177001654618 0.9860827708185 -0.0983768160085265 0.471377839610756 0.774962086083438 -0.261917358095178 0.26375158794362 0.143393149103953 0.483004732971773 -0.118524208991225 0.595332156027235 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTNNBL1 0.0105704201733697 0.952054160612164 0.9860827708185 -0.171156668653221 0.341266674287606 0.688928020483469 1.3476479073055 1.0 0.187482750065218 0.558041385550551 -0.230686361932601 0.35953869272403 -0.0432036118673823 0.893473255962837 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MMP17 -0.0238597582278566 0.952086357806761 0.9860827708185 0.254626019762442 0.525882645693587 0.804676662787375 0.538889081656801 0.21075460129208 -0.308741511261696 0.365991737449 0.230147570395105 0.588012190000614 partial_or_other False False False False False False False 0 insufficient_or_context_specific +E2F6 -0.0179164922467374 0.952366414454328 0.986104723795651 0.0721104507666745 0.806965736012396 0.932788199072101 0.161416076839012 0.642436051472277 -0.101589636367146 0.713587390909983 0.0598264404718662 0.857233256423977 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMAP2 -0.0187412353660534 0.952415842519079 0.986104723795651 -0.195927396198368 0.526496090780986 0.804819865166353 0.0690733807360023 0.815171844574446 0.149566406949854 0.476598941734544 0.218639787685857 0.328683855607637 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RRN3 -0.0147011786404323 0.952481149201369 0.986104723795651 0.0371233599129284 0.880491800239739 0.96227446663699 0.337843825263354 0.252551934410784 -0.0349411141883927 0.90272585784079 0.302902711074962 0.264210961910111 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CFL1 0.0207960447171023 0.952660308359058 0.986111489229098 -0.161724410135053 0.652854547906858 0.870374832458737 0.317040655663733 1.0 0.344320094844765 0.306578765407392 0.0150522774865659 0.964777639241004 0.359372372331331 0.239814743755085 partial_or_other False False False False False False False 0 insufficient_or_context_specific +HCFC2 -0.0120648304942803 0.952732773050896 0.986111489229098 0.0810295677993305 0.692627837715539 0.886799724697293 0.243411681781873 0.403519974417205 -0.197154832920648 0.409121456014631 0.0462568488612252 0.880282795454404 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYL3 0.0244632734813339 0.952908741008319 0.986111489229098 -0.514520751322143 0.182267936613855 0.56456240235188 0.28815088397468 0.763979797613914 -0.317205160603979 0.639098676933425 -0.029054276629299 0.97581128444569 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MSH2 0.0175943755242171 0.953161737231872 0.986111489229098 -0.359270598216087 0.207933276662884 0.580700057930969 -0.345773672474566 0.320349903765884 -0.011024085169616 0.974423910121543 -0.356797757644182 0.259352100387966 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MORC2 0.0095633839172125 0.953234254848038 0.986111489229098 0.0287543329222342 0.859938444955908 0.956914759994669 True False False False False False False 0 insufficient_or_context_specific +RPL22 -0.0150137408483463 0.953554809032406 0.986111489229098 0.0137724347922704 0.957448360721379 0.987656798648419 0.358259688014144 1.0 False False False False False False False 0 insufficient_or_context_specific +BCCIP -0.0161366733018315 0.953604884895908 0.986111489229098 0.0817629854578096 0.768549903395079 0.919804688785064 0.0286453740304076 0.93061952943084 0.168110237464181 0.443482406252529 0.196755611494588 0.396218295154715 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INPP5K -0.0167150828876594 0.953624855044003 0.986111489229098 -0.445463249842722 0.122798465863574 0.504082700851544 -0.397442877597987 0.248677650064049 0.0147282568705183 0.966369504880937 -0.382714620727469 0.225744774506919 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C16ORF87 -0.0172750212991432 0.953671221155253 0.986111489229098 0.232577132541552 0.452032466178586 0.764220781091034 False False False False False False False 0 insufficient_or_context_specific +PSIP1 0.0139148741758194 0.953749783834625 0.986111489229098 0.158763744087109 0.505150846618632 0.792832263802515 -0.188969809903679 0.403880964912857 0.115976762637601 0.550717539478891 -0.0729930472660779 0.739668529622418 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PRICKLE1 -0.0203363104346875 0.953782281694085 0.986111489229098 -0.288482317223937 0.407084323482647 0.733976772200131 0.31004123363915 1.0 0.730443533613273 0.154195880760556 -0.165550316014001 0.685417356632217 0.564893217599272 0.236889918410491 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF518A 0.0080202851429082 0.954294599230324 0.986434538738375 -0.108704536026368 0.432664390971017 0.751348529890037 False False False False False False False 0 insufficient_or_context_specific +DNAJC27 0.0208731156839223 0.95463929908965 0.986654931577523 -0.395848909776648 0.270303348695475 0.634531964851516 0.31347284372992 1.0 0.235241890169502 0.758158147574253 -0.204646617665006 0.707994043097852 0.0305952725044955 0.967167277207169 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KLHL21 0.01648247517559 0.954733918984789 0.986654931577523 -0.0034029559930535 0.990940128234569 0.997458849642538 0.23679282148953 1.0 -0.390820349349518 0.246213051974469 0.663688248883138 0.0350141101923505 0.27286789953362 0.37305938205724 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ADGRG7 -0.0446250323209046 0.955070665250297 0.986654931577523 -0.328952143942139 0.66037670546119 0.872407073022888 False False False False False False False 0 insufficient_or_context_specific +NBN -0.0111839055379908 0.955143132210461 0.986654931577523 0.0410015472338902 0.838529184656607 0.947980633001869 0.197181277226724 0.643226897816119 0.122522852306692 0.710177647350917 0.319704129533416 0.364852761162571 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DIP2A 0.0096306260724132 0.955153875831312 0.986654931577523 -0.0804831824773611 0.631767864586881 0.860199479641986 0.396491984575845 1.0 0.192388296029342 0.549523397858711 -0.412235300764334 0.112480809556542 -0.219847004734992 0.436029270599682 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SIAE -0.0142170526725045 0.955319820476136 0.986654931577523 -0.112441021505735 0.650554521734428 0.869901306439436 0.464761925155374 1.0 -0.005595658617378 0.988902602115371 0.451710373475376 0.0765077613427429 0.446114714857998 0.102340682986795 partial_or_other False False False False False False False 0 insufficient_or_context_specific +YTHDF1 -0.0102841633876621 0.955372668488481 0.986654931577523 -0.0810574418174427 0.659607266907537 0.872261212927076 0.0029308921500571 0.994569627043916 0.250957890474751 0.362589375743519 0.253888782624809 0.394133886986746 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF791 -0.0079415390230587 0.955385427215679 0.986654931577523 -0.10194232112112 0.46144193567166 0.769126302007068 False False False False False False False 0 insufficient_or_context_specific +NTRK1 0.0243558299078174 0.955627392877829 0.986654931577523 -0.280285454846011 0.511570943229629 0.79686722021517 False False False False False False False 0 insufficient_or_context_specific +PJVK -0.0237345797669658 0.955994957884245 0.986840876401721 -0.340292399415959 0.404099293349341 0.732568739557408 False False False False False False False 0 insufficient_or_context_specific +COX19 0.0112896534600796 0.956124031843773 0.986840876401721 -0.135198801147981 0.502782184591095 0.79229878349175 -0.290244749896854 0.470733501373365 0.822148584671492 0.0213464770444198 0.531903834774639 0.124712626925293 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC137 -0.0152849318598637 0.956145837183196 0.986840876401721 0.0105839988671956 0.969531732631626 0.991737938845345 -0.0819299361379583 0.827615651342179 -0.661024903572799 0.025784706950031 -0.742954839710757 0.0238621642159009 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC005746.2 0.0192896018254889 0.956183194316121 0.986840876401721 -0.141732173267397 0.675904562746027 0.879058927503394 False False False False False False False 0 insufficient_or_context_specific +MYC 0.0279521782057454 0.956706639001777 0.987091193808538 -0.33450302202236 0.595562309021097 0.840747006103054 0.290605740532654 1.0 -0.315544639618547 0.643226897816119 0.364682447872367 0.492401829525547 0.04913780825382 0.940961636105127 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF454 0.0243877633255141 0.956727052758819 0.987091193808538 -0.369237951366791 0.366988157893488 0.708218053562318 False False False False False False False 0 insufficient_or_context_specific +MAPKAPK2 -0.0135026191149091 0.956893838866905 0.987091193808538 -0.0152478200899793 0.951316268314001 0.986917609553614 0.9698332541539209 0.0686921442965724 0.110226461577973 3.0 -0.20699060423524 0.464154497742117 -0.23189561599033 0.326598881251162 -0.43888622022557 0.0866969851923221 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INTS3 -0.0128764640722197 0.956942122449864 0.987091193808538 0.0266273933526045 0.910513639300894 0.972012437182896 -0.106844727379849 0.710349119751743 -0.0362291581450569 0.886969161216543 -0.143073885524906 0.557422362455443 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNF126 0.0118018693861684 0.957171425879964 0.987091193808538 0.112820677074868 0.610345657947803 0.848355438906531 -0.248649592437913 0.34965161356768 -0.346828484383662 0.13465484712742 -0.595478076821575 0.0274395667885419 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MRPL58 -0.0218788450159523 0.957173673253629 0.987091193808538 0.19530117905088 0.630992917470338 0.859726832191486 False False False False False False False 0 insufficient_or_context_specific +CHD1 -0.0102359577946103 0.957337832541371 0.98716406250335 -0.0812167486533202 0.672886006725989 0.877361032137705 -0.0939101745561644 0.731556142006226 -0.453655073926351 0.0440117165861163 -0.547565248482516 0.0273197270267665 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF213-AS1 0.0128288320047602 0.957819417189458 0.987525295176175 -0.21249872457179 0.383981039994292 0.719298323474503 False False False False False False False 0 insufficient_or_context_specific +OGA 0.0092585798844228 0.958583112626884 0.988158611903402 -0.0070576078410251 0.968246396871312 0.991065707083724 0.401857836517577 0.515083662160046 2.0 0.0681072221313192 0.830261829930927 -0.164385738438858 0.467681158598617 -0.0962785163075384 0.709113721153133 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DENND1A -0.0133755617094519 0.958786599595257 0.988271885046053 -0.111063913386855 0.667526000386917 0.875419277100913 0.0552946379203876 1.0 -0.24333058572512 0.548278111228744 0.342732457407483 0.290875026512471 0.0994018716823632 0.795881235019117 partial_or_other False False False False False False False 0 insufficient_or_context_specific +COQ10B 0.014347934497249 0.959080426438913 0.988299743660993 -0.0001067927717 0.999814587257213 0.999821029388173 0.381172215098972 0.207302088438974 -0.336177781087337 0.189228298852976 0.0449944340116346 0.892394606098011 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC7A5 -0.0388327478754771 0.959094144153505 0.988299743660993 -0.267206902142748 0.71530399741629 0.897253131129997 0.793259302452212 0.207801911668612 -0.467911881906746 0.322278415348674 0.325347420545466 0.610314493143486 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MLF1 0.0248489175017221 0.959209186421164 0.988299743660993 -0.616529127828894 0.258248770917086 0.622136927842961 False False False False False False False 0 insufficient_or_context_specific +NR2F1 -0.0146205332043676 0.959296484471008 0.988299743660993 -0.0460516840111729 0.872088141058958 0.958815640247889 0.0515297838408966 1.0 -0.0916305585962768 0.874270640716158 0.23489872789487 0.541763927308012 0.143268169298593 0.756482372894164 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RHOXF1-AS1 0.0150013925710688 0.959297111688195 0.988299743660993 -0.136382576807758 0.642030310269875 0.864832357212215 False False False False False False False 0 insufficient_or_context_specific +SETX -0.0074559077307324 0.959375267359492 0.988299743660993 -0.0430030593374652 0.767431095371638 0.91954879692023 0.307075732203784 0.409718192601624 2.0 -0.0147641888495869 0.979529392920331 0.0737360822887768 0.857359525187459 0.0589718934391899 0.899913967607676 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CFDP1 -0.0085541625606933 0.959546163157844 0.98837935518249 0.0311544372593402 0.852517934853197 0.954623291862556 0.0509777411031733 0.856375858040323 0.0462590127038565 0.829262890399747 0.0972367538070297 0.659788869519024 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPP14 -0.0153593013778741 0.95967501198539 0.98841564496554 0.307032836543012 0.325247627797141 0.674724889947951 -0.0943986823610554 0.834111176420739 0.203016604865031 0.506797379821283 0.108617922503976 0.768139349059199 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PALM 0.0132851727102123 0.959808282555385 0.988456481390925 0.220913610174421 0.434245615998181 0.751847362038176 -0.132847662357975 0.662459607246125 -0.66761110512959 0.0158859278772516 -0.800458767487566 0.0103963845359275 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MTFR1L -0.0186443924761611 0.96019355181091 0.988709379822801 -0.0603471399339968 0.869537608186673 0.958502690861149 0.320181833807778 1.0 -0.0676013799757093 0.838926625342593 0.13908961582641 0.548354205465312 0.0714882358507007 0.794341508889229 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP2K4 -0.0097366518209299 0.960241142328376 0.988709379822801 0.0497112655762308 0.801136727968994 0.93041486897994 -0.131941705063365 0.763984226718305 0.182935750621664 0.564815643453354 0.0509940455582988 0.898913010886221 partial_or_other False False False False False False False 0 insufficient_or_context_specific +BUD13 0.0183865248618328 0.960541267805215 0.988921960554604 0.147968978355551 0.684059994914904 0.882766419515653 -0.21625218764059 0.592444258755827 -0.489883155099909 0.134506766919864 -0.706135342740499 0.0556752012051446 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HAVCR2 0.0188472865174014 0.960815599467883 0.989107946488095 -0.182704446072232 0.635699825204025 0.861898723009269 False False False False False False False 0 insufficient_or_context_specific +DYNLL2 -0.019330082279995 0.961130531553418 0.989335688031684 -0.108542987912424 0.786729853143826 0.926121604088118 0.6301704817978859 1.0 -0.0864398092887945 0.87470037044205 0.730821168937997 0.0674997606230402 0.644381359649202 0.114681685105138 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MCPH1 -0.0079554530915729 0.961234029010956 0.989345767040131 0.137700918343987 0.377927894857334 0.715214004833462 0.160859921551302 0.65510220231222 -0.799024261044151 0.0140708034546725 -0.638164339492848 0.051718886074964 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OTUD6B-AS1 -0.0145336975231047 0.962131839351069 0.989767385420835 -0.270065237392389 0.369166499969799 0.709345639075664 False False False False False False False 0 insufficient_or_context_specific +BTN3A2 0.0201816964094287 0.962252273705463 0.989767385420835 0.0735614383150659 0.865683586854348 0.958391272020028 True False False False False False False 0 insufficient_or_context_specific +RAP2C -0.0143913475323614 0.962299887416638 0.989767385420835 0.18323681414761 0.537733843051809 0.812087893451657 -0.249399191821911 0.427896022950611 0.103175500609315 0.705586875829981 -0.146223691212595 0.616675950996044 partial_or_other False False False False False False False 0 insufficient_or_context_specific +APOL2 -0.0111140189317282 0.962710758662741 0.989894006954299 -0.0852276085749971 0.711826070952502 0.895497343705388 0.48629297006307 1.0 False False False False False False False 0 insufficient_or_context_specific +LINC00923 -0.0360036801437935 0.962755180501696 0.989894006954299 -0.197497724873122 0.782558971606396 0.924647355053618 False False False False False False False 0 insufficient_or_context_specific +C7ORF50 0.0146026930977178 0.962820593500551 0.989894006954299 -0.0218431954010806 0.944850815767435 0.985105732892783 0.668726528309593 0.25805211443708 0.0375611236259259 3.0 False False False False False False False 0 insufficient_or_context_specific +BACE2 -0.0131727164722235 0.962918168941137 0.989894006954299 0.16106593297498 0.563540360060506 0.823754286312897 -0.306596301394117 0.429970947227219 0.743572233203622 0.0314355661023586 0.436975931809505 0.19487999323351 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TJAP1 0.0105223280909581 0.963079299056124 0.989894006954299 -0.183299986271225 0.430102827065848 0.748849876016033 0.0378935935648455 0.91811179760286 -0.636220430277187 0.0222986480369765 -0.598326836712341 0.0386673147865856 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNRF1 -0.0123386570713975 0.96409438607562 0.990394632839926 -0.0614278015837965 0.82125925922561 0.938404248799134 -0.42302841536309 0.0972061039159886 -0.202532420332014 0.368311499380993 -0.625560835695104 0.0206212459289334 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PBXIP1 0.0139624124768683 0.964139536727051 0.990394632839926 -0.0926121730769461 0.789554050101214 0.927187163688279 0.414929697425486 1.0 0.423071735421646 0.140955028175922 -0.495627838836035 0.056007816618294 -0.0725561034143884 0.809839256930939 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MS4A6A 0.0285222528268239 0.964205661746782 0.990394632839926 -0.896296183307873 0.150429076628623 0.533583468169136 False False False False False False False 0 insufficient_or_context_specific +ST3GAL5 0.0163895317685219 0.964237887904999 0.990394632839926 -0.297650631303174 0.451529020464524 0.764202910889105 -0.141338165942588 0.777032579014751 0.688674533387083 0.0738306569115781 0.547336367444494 0.1620055763325 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM135 0.0099010187867706 0.964389795765537 0.990394632839926 0.181246459587707 0.402530080259642 0.731482373043253 -0.217677974269095 0.418340764182583 0.294931296977452 0.191579513057265 0.0772533227083568 0.769026048029419 partial_or_other True False False False False False False 0 cross_species_direction_conflict +TTC12 -0.0098401077089997 0.964520719762884 0.990411375146521 -0.219017267197142 0.328362433274217 0.677287114006341 0.492022689789267 0.471559024707406 -0.397662512669254 0.434148730058819 0.0943601771200136 0.896869437755745 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DHX38 -0.0090537903597672 0.964913917183568 0.990659749007039 -0.075808383240109 0.712953057345069 0.895497343705388 -0.165902049572473 0.59385245876347 -0.470877926956588 0.0712008489272627 -0.63677997652906 0.0301135439163634 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PSMB9 0.015733737923217 0.964950261298389 0.990659749007039 0.494887645249805 0.163155515676069 0.544298760692042 -0.53346626715865 0.0666968154755362 0.523221405262885 0.0450074559313707 -0.0102448618957656 0.974248396582174 reversed True False False False False False False 0 cross_species_direction_conflict +KLHL36 -0.008271756773186 0.965068228369332 0.990684526506895 -0.134390598467458 0.476068326839243 0.777939354595146 0.529485888811381 1.0 -0.434888565652376 0.271924106769673 0.183675593537056 0.590051116766908 -0.25121297211532 0.491876517329037 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RSRC2 -0.0091611777560155 0.965587982696172 0.991023031746521 -0.14668440034362 0.480695250014342 0.780346070738476 -0.195829696205421 0.569802251321149 -0.648838741264426 0.0342785101277541 -0.844668437469847 0.0157085404080183 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SEC31A -0.0079478474623424 0.96559359507791 0.991023031746521 0.13369624464495 0.458694883933143 0.768201799558117 0.0952420248423445 1.0 -0.0658076422418121 0.820934777145911 -0.126804004821248 0.553415676675456 -0.19261164706306 0.382490927502614 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KIF1BP 0.0143648342654135 0.965679574787669 0.991023031746521 -0.330516185220737 0.299708634093577 0.658000365722601 1.06946027148438 1.0 0.0579521373818033 0.856473630588214 0.0297897712310817 0.90608511988179 0.087741908612885 0.732366918514764 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC244131.2 0.0190516536634889 0.965912168039988 0.991150009520038 0.591477227181447 0.16993841605804 0.550151003380263 0.0710290501870926 1.0 True False False False False False False 0 insufficient_or_context_specific +KMO -0.0270966581274224 0.965991058719568 0.991150009520038 -0.193999098900194 0.75054354852203 0.911659131290248 -0.903585505984764 0.0199628541868525 0.731980855199456 0.0360478117407268 -0.171604650785309 0.625804260474455 reversed False False False False False False False 0 insufficient_or_context_specific +HEBP2 0.0107026540889098 0.966635231332657 0.991489397342079 0.0066902021553121 0.979025139778961 0.993800106187985 True False False False False False False 0 insufficient_or_context_specific +SRFBP1 -0.0120400473338802 0.966638176210455 0.991489397342079 0.288121409193258 0.31628974108389 0.668679833072429 -0.289862439569027 0.405949448831043 -0.0326463507936888 0.923289101427856 -0.322508790362716 0.300728833655718 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMEM100 0.0277932054312947 0.966653160928155 0.991489397342079 -0.582267720293395 0.37099648019317 0.709983838658598 0.474683735766595 1.0 -1.28667028588678 0.126658357844494 1.20133975178362 0.104984278189202 -0.0853305341031599 0.922406365574973 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RPRD1B 0.0066172123769816 0.966697466967168 0.991489397342079 -0.144425702700171 0.363858305486769 0.705142435633133 -0.237690295604947 0.445745076464153 0.0566170138713105 0.84347527882395 -0.181073281733636 0.521594863745992 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF814 -0.0077678020953441 0.966902967837344 0.991603840158006 0.135884629711534 0.466286189463534 0.771256747133237 False False False False False False False 0 insufficient_or_context_specific +GUCY1B1 0.0131333318236522 0.967083485060686 0.991631772518489 0.106739457659598 0.736926116204198 0.906074989505523 1.01744903171675 1.0 -0.0614921524511429 0.873684498675585 0.204837749393795 0.451140330448465 0.143345596942652 0.633944137613951 partial_or_other True False False False False False False 0 cross_species_direction_conflict +G0S2 -0.0231525443713223 0.967365080725366 0.991631772518489 1.18592219965087 0.0473350543466186 0.401231297569097 0.389580054917611 0.233658535785586 -0.340026917903377 0.235556565696117 0.0495531370142339 0.888082602337239 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POM121C -0.0063448028399811 0.967439953647293 0.991631772518489 -0.0295204421996617 0.849008430670033 0.953127856970211 0.3284971104578061 1.0 False False False False False False False 0 insufficient_or_context_specific +PEX7 0.0105529492088602 0.967457778533228 0.991631772518489 -0.0205093356931986 0.937193613733944 0.98270832990396 -0.0779221240038678 0.882056957133274 0.614610226266751 0.0817457232206107 0.536688102262883 0.153703630882635 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TMTC2 0.0166329523791048 0.967510943201201 0.991631772518489 0.178600542858076 0.657024865941655 0.871684912617742 -0.208796700016471 0.692046018169297 -0.166026636042216 0.689930419964178 -0.374823336058687 0.393462308241816 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ANAPC1 0.007136487096482 0.967587660587751 0.991631772518489 0.034817463393058 0.843343795744899 0.9506514118099 -0.164211763023695 0.609499484933459 -0.243614488864305 0.345287820363438 -0.407826251887999 0.137861228319892 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SLC16A2 -0.0087905349657863 0.968143387021676 0.991950682066277 -0.0248529311085169 0.910150438170516 0.972012437182896 -0.274571850824027 0.525073663158882 0.884345478684054 0.0211539776270351 0.609773627860027 0.101321538244604 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NFATC4 0.007210943304803 0.968180695083632 0.991950682066277 -0.0208598820801826 0.909275529715489 0.971583494396145 0.10064983784612 1.0 1.21103617113353 0.010802228400847 -1.64603445359189 0.0019872992848927 -0.434998282458358 0.316667361574571 reversed False False False False False False False 0 insufficient_or_context_specific +PPP1R3E -0.0125861958852046 0.968278148331567 0.991953889419324 -0.0083003177601587 0.979159095780634 0.993800106187985 0.0234318810155587 1.0 -0.393765850184206 0.451212276969693 -0.495359545472309 0.258730308671448 -0.889125395656514 0.0761110811469107 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATOH8 -0.0169974428678617 0.968619884400256 0.992024962040624 -0.0554883919752124 0.892403215276923 0.965368150296491 0.243266384472334 1.16214925666067 2.0 0.581982859115028 0.101570060360601 -0.110432445099223 0.734751187752125 0.471550414015804 0.152969158602762 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LCMT1 -0.0071825203827859 0.968629033309035 0.992024962040624 0.0393300598665687 0.831002185871067 0.943790632272401 0.024262531398397 0.952591111902262 -0.196186633153482 0.462759542141023 -0.171924101755085 0.570878595748841 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NPM1 -0.0093500135046322 0.968759821836412 0.992062676910654 0.0799364152691316 0.741081996101229 0.908406208990048 -0.204455301558964 0.501456236645558 0.10632023855723 0.684327199541759 -0.0981350630017347 0.732755111122619 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL078459.1 0.0086506574534179 0.968944604738868 0.992096116545476 0.13703596601312 0.545402819586563 0.815346883112321 True False False False False False False 0 insufficient_or_context_specific +ZNF7 -0.0128317797313105 0.968980408582776 0.992096116545476 -0.132710747053913 0.676544819730217 0.879146834479876 False False False False False False False 0 insufficient_or_context_specific +ZNF441 -0.0131036882876665 0.969336891641416 0.992334179128161 -0.0217645152395983 0.948608849430988 0.986642915209573 False False False False False False False 0 insufficient_or_context_specific +PICK1 0.0149523485182023 0.969400902020066 0.992334179128161 -0.121002399466756 0.767440188582033 0.91954879692023 0.8538955669215681 1.0 -0.481122367860982 0.271878844309066 0.0247544718812131 0.954599121414487 -0.456367895979768 0.253876832241281 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POLE4 -0.0164371253388341 0.969791355003151 0.992637627350777 0.0214408424276081 0.959871252325138 0.988617762369409 -0.301996349916312 0.36004710290144 -0.0792113428596387 0.794442764242641 -0.381207692775951 0.201424766782631 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ARSD -0.0143895340901032 0.970127737100492 0.992789439595521 0.0656782247951301 0.865827937621256 0.958391272020028 0.350288306854568 1.0 False False False False False False False 0 insufficient_or_context_specific +CD226 0.0146039385591409 0.970429452748771 0.992934584188041 -0.401816054526084 0.310488405268429 0.663859170276241 0.37653518212435 1.0 False False False False False False False 0 insufficient_or_context_specific +TGS1 -0.0060853072634421 0.97045765999587 0.992934584188041 0.133585451040992 0.426247773361795 0.746941741270346 0.283346515547293 0.411613070834813 -0.22004443554736 0.423118529826509 0.0633020799999332 0.858711457595346 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC15A1 0.0278208438626536 0.970694780805947 0.993064219695682 0.0852535159915062 0.913941841542446 0.973899673294826 True False False False False False False 0 insufficient_or_context_specific +WRB 0.0088576448373501 0.970772476934944 0.993064219695682 -0.0383992216712201 0.87153443403193 0.958683313195135 -0.330459489992486 0.347101628803026 -0.0324704460339775 0.924756353965714 -0.362929936026463 0.25447722939956 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAP3K13 -0.0090181599276566 0.971015427402408 0.993148421080372 -0.102860074055579 0.677341620512819 0.879735862882808 0.4325984008378621 1.0 -0.157879879137043 0.688936764998849 -0.31772759602389 0.2911782078535 -0.475607475160934 0.151608152980277 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NDUFS2 0.0074348716044673 0.971283779911453 0.993148421080372 -0.0370972018719723 0.858913551951727 0.956914759994669 0.585055725219397 1.0 -0.251128570528678 0.519584861503389 0.453535919509231 0.161546381900687 0.202407348980553 0.562013135305422 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC02532 0.0210012476146049 0.971526056692254 0.993148421080372 -0.145765006456994 0.806888597764563 0.932788199072101 False False False False False False False 0 insufficient_or_context_specific +DDX17 0.0064561052547803 0.971547890844789 0.993148421080372 -0.0565290571280215 0.753566672744604 0.913602082065829 0.124366664071673 0.74609209468542 -0.664867147766331 0.0370071436187702 -0.540500483694658 0.086888960452416 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRANK1 -0.0105492901078499 0.971619755042924 0.993148421080372 -0.129780414889251 0.66108174860254 0.872692182378332 0.512395572316239 1.0 False False False False False False False 0 insufficient_or_context_specific +ZNF384 0.0090692239453457 0.971624013094842 0.993148421080372 -0.0082645058625244 0.97412093565351 0.992450915625761 False False False False False False False 0 insufficient_or_context_specific +HRG 0.0158330104695266 0.971796987678631 0.993148421080372 0.179102225898487 0.688906063165537 0.884999569552245 -0.993396314224901 0.054780724759655 1.5141071971325 0.0068159840692994 0.520710882907596 0.261068935427344 reversed True False False False False False False 0 cross_species_direction_conflict +RBFOX1 -0.0180719205949585 0.971996399740806 0.993148421080372 -0.169707583710416 0.729918552798752 0.904213522802984 -1.32937558929448 0.205128339300846 -0.352912376459168 0.748207782550289 -1.68228796575365 0.103200366856994 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UGT2B7 -0.0195755359712383 0.972065630234092 0.993148421080372 0.231813119181011 0.680366487605433 0.881048329971919 False False False False False False False 0 insufficient_or_context_specific +JUP 0.0095912095647403 0.972177218654805 0.993148421080372 0.0516721420553153 0.852766206111351 0.954772598528488 0.625298356942213 1.18048873282856 2.0 -0.305067085477399 0.318003699851839 0.740448583912094 0.015199749014023 0.435381498434695 0.120387622541497 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AFG1L 0.0070389505602713 0.972258872304466 0.993148421080372 0.251867022011802 0.19157387265513 0.570552915001293 0.395749191038912 1.0 -0.482505881983662 0.306057249709952 0.0847199732631066 0.849004335664208 -0.397785908720555 0.352137625062923 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LINC01504 -0.0174103199955426 0.972509485483195 0.993288199952033 0.272574418942319 0.589227211467136 0.836388935018826 False False False False False False False 0 insufficient_or_context_specific +SPNS1 0.008921291600782 0.972590775819674 0.993288199952033 0.251587746178379 0.339159662183012 0.686946959803023 0.999729895624039 1.0 -0.172107246314463 0.625928290059048 -0.192702027347164 0.492553941573279 -0.364809273661627 0.220882890672601 partial_or_other True False False False False False False 0 cross_species_direction_conflict +APOB -0.0129506702930796 0.972855036130135 0.993461985826672 0.0221927779071892 0.953526597748082 0.98728388928354 0.681836582894905 0.961576596988754 2.0 -0.625833165682549 0.255825231608412 1.0639746513962 0.0422907843958007 0.438141485713649 0.385722139440129 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SERPINC1 -0.013063082421432 0.972986372629823 0.993500011820664 -0.0574020891824015 0.880277542571412 0.96227446663699 -0.934054215548921 0.0500462821154033 1.60523433245582 0.0038496969547946 0.671180116906896 0.120393092860076 reversed False False False False False False False 0 insufficient_or_context_specific +FGF1 0.0145388096677832 0.973211199343395 0.993633482513062 0.0545457591307202 0.903391126715887 0.96950635453002 0.5604283139143961 0.8453911166461658 2.0 -0.85284352479279 0.0296740641053343 0.980599127337081 0.0106742815150993 0.127755602544292 0.727350119776988 reversed True False False False False False False 0 cross_species_direction_conflict +PTPN2 0.0062407466025349 0.973396585181032 0.993652420531912 0.11890245715203 0.520149664101407 0.801118945922776 1.04004740620988 1.0 -0.0223766020706153 0.964510570781438 -0.114810209829347 0.745787952824322 -0.137186811899963 0.729902984551168 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WDR43 -0.0063091041189106 0.973563082350281 0.993680525441049 0.166664060137666 0.379844735531603 0.716424065042321 0.461309058046484 0.0811757907603572 2.0 0.246591701608365 0.466697815872244 -0.370152853204394 0.180458365392657 -0.123561151596029 0.704227246012272 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TCAIM 0.0057988231306426 0.973700439333278 0.993680525441049 -0.049224839007873 0.779222913777379 0.923037756497427 0.7257509010458109 1.0 -0.0026715782461599 0.996779540451992 0.117787917708478 0.79475891170579 0.115116339462318 0.826646519991694 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PELI1 -0.0102083939042235 0.973727857190101 0.993680525441049 -0.134687120231073 0.667693747351631 0.875419277100913 -0.157135958960037 0.564491967128567 0.0322169662537906 0.899903010515023 -0.124918992706246 0.608119365637099 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RREB1 -0.0050896341886247 0.973869777425604 0.993729304151883 0.04711931814388 0.763439537304056 0.916866798061945 1.37485300871437 1.0 -0.296605399944879 0.293410099944168 0.143546714292688 0.562726262971166 -0.153058685652191 0.566137624448554 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DNAJC2 0.0078091108860735 0.974674264746935 0.994261921468419 0.110784112639731 0.652518648904733 0.870374832458737 -0.173755923335777 0.685678336076267 0.21911392420122 0.492879899180026 0.0453580008654434 0.912183542250547 partial_or_other True False False False False False False 0 cross_species_direction_conflict +RRP12 0.0109484657437444 0.975678851135081 0.995178161744376 -0.105226913416111 0.785993374184205 0.926121604088118 False False False False False False False 0 insufficient_or_context_specific +EHBP1 0.0083896256710452 0.975981203661392 0.995306630759874 0.0898543775830791 0.746813917066156 0.909830759894547 0.698173305392624 1.0 -0.0438834946238917 0.903037482443384 -0.174718282917783 0.480659714054748 -0.218601777541675 0.402275858739795 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ARHGAP20 0.0133188983123008 0.976217565599002 0.995451521884707 -0.142426642929806 0.739782533276149 0.908274440555399 1.87191713690974 0.0361997428441692 -1.51267484886254 0.0258302488325242 0.359242288047202 0.734568759125831 reversed False False False False False False False 0 insufficient_or_context_specific +LNPK 0.0065576330995515 0.976341149470731 0.995481396051374 -0.195649775955979 0.389528185747135 0.722218665388488 0.8427266908362541 1.0 -0.0173252716112601 0.962850315611004 -0.132361309307671 0.601370426415146 -0.149686580918932 0.593965915610127 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC142 0.0081664524738775 0.976534739373284 0.995505392247073 -0.369777425985776 0.149910311175266 0.533583468169136 -0.0403414027898613 0.945779519921482 -0.792769725031169 0.0584308761476101 -0.83311112782103 0.0670324052500536 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CRIP2 -0.0155164835054676 0.976601064399857 0.995505392247073 0.213646856995622 0.674441843532909 0.878130100384814 -0.342460494848476 0.200820081464291 0.749571876656389 0.0086109352167552 0.407111381807913 0.104283077045815 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AAMP 0.0071422501462759 0.976647551893842 0.995505392247073 -0.240550862134323 0.33318265819501 0.683012168398942 0.169795439006183 1.0 -0.110916731955096 0.7188507548735 0.0256871639903799 0.92724733321704 -0.0852295679647159 0.756482372894164 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LAMP1 -0.0068570936945849 0.976835847608629 0.99560120465797 0.0060904917353737 0.978889471915489 0.993800106187985 -0.0778644269453378 0.852341521006602 0.514759714928526 0.088346677370223 0.436895287983188 0.157700527672553 partial_or_other False False False False False False False 0 insufficient_or_context_specific +GIMAP8 -0.0199009099997717 0.977109242145119 0.99569802998073 -0.848649684149395 0.197269340822453 0.572466025511161 0.0957286838808974 0.884071215441952 -0.314007706817908 0.466145847997788 -0.218279022937011 0.676796475692091 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIAS -0.0081027063795243 0.977119462836744 0.99569802998073 -0.126976310968127 0.636810392144506 0.862201092621402 0.0176640505734761 1.0 -0.0017738279458196 0.996654745472828 0.162829704373395 0.520179627167617 0.161055876427575 0.568884245716244 partial_or_other False False False False False False False 0 insufficient_or_context_specific +IARS -0.0062613143143278 0.977387343857312 0.99577873583299 0.32010679853328 0.12901268150828 0.513231307974535 0.0870190660914677 1.0 0.180160998348941 0.611241804832431 0.0350515085244057 0.913648260987648 0.215212506873347 0.477609991195525 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RNGTT -0.0054068772939141 0.977431479996193 0.99577873583299 0.0459160125349732 0.809046364619428 0.932943578867351 0.2752741178024939 1.0 0.0034798141840643 0.995740876664603 0.228973610172742 0.530564148083358 0.232453424356806 0.582250270704913 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AMD1 -0.0077975048111158 0.977548808117828 0.99577873583299 0.351992036279879 0.197647993898283 0.572510820330333 False False False False False False False 0 insufficient_or_context_specific +YJEFN3 -0.0135858958544301 0.977575923177585 0.99577873583299 0.0175071952326542 0.966479389591999 0.990805143378026 False False False False False False False 0 insufficient_or_context_specific +EPHA4 -0.0096299863160318 0.977760159426673 0.995841813413664 0.240180724862494 0.510348812041648 0.796519013040946 -0.436148287949252 0.490328202039014 -0.54203206707448 0.306038125638246 -0.978180355023731 0.100871297053897 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CWC15 0.0057293505150013 0.977912912081096 0.995841813413664 0.0271542204775061 0.899189806201288 0.967837995533705 0.8221605545888829 1.0 -0.350185124140298 0.268640494859393 0.720731231901363 0.019243312152855 0.370546107761065 0.196010290284305 partial_or_other True False False False False False False 0 cross_species_direction_conflict +CDK5RAP1 0.0045680718147121 0.978161221350204 0.9958986381827 -0.201071091210509 0.236560416568667 0.605329180588419 -0.0109719519998896 0.981491186794154 -0.165766095426887 0.605896932728158 -0.176738047426777 0.625612244364974 partial_or_other False False False False False False False 0 insufficient_or_context_specific +THOC5 0.0059450169381703 0.978333393489659 0.9958986381827 -0.0120842045195082 0.955448346747581 0.987410276805219 -0.141048485829735 0.69670494180352 -0.0093348260679629 0.976988604339066 -0.150383311897697 0.632603828449001 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PTP4A3 -0.0188351568858508 0.9783539188512 0.9958986381827 0.18707586126197 0.760692172403538 0.915734238148068 0.378365262438198 1.0 0.693360750947424 0.0759092788243385 -0.658260196179641 0.0594532811946558 0.0351005547677829 0.934240347957583 reversed False False False False False False False 0 insufficient_or_context_specific +ARHGAP24 0.0077893587725884 0.978705322116977 0.996003335662695 0.324781133943534 0.247969853617424 0.613848936575092 0.7397232326444558 1.0 -0.512405213772299 0.101570060360601 0.818995389518895 0.0107797897443128 0.306590175746596 0.279928442651292 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HAL -0.0194095824532918 0.978796196888681 0.996003335662695 -0.165471471229779 0.819751307989925 0.937645994477492 -1.11051404130561 0.0460592191823541 1.18070263443675 0.0261109460082666 0.0701885931311406 0.903533812295188 reversed False False False False False False False 0 insufficient_or_context_specific +UNC5CL -0.0163156670434487 0.978837194830831 0.996003335662695 -0.118970397157954 0.836662922649155 0.947349959049485 False False False False False False False 0 insufficient_or_context_specific +KAT14 -0.0078545798534739 0.978934216190582 0.996003335662695 -0.0453751583691314 0.87594187305825 0.960551962582987 0.221677702355864 0.38692805555038 -0.467916576270119 0.0420475299206381 -0.246238873914256 0.289980610219135 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PLPBP 0.007394067690159 0.979026670023609 0.996003335662695 0.222116937828374 0.480559632460144 0.780346070738476 -0.471113103772301 0.0575780237830355 0.156968607288236 0.465288220670189 -0.314144496484065 0.163121315303302 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WDR53 -0.0089532904356027 0.979245419673794 0.996036348455642 0.329473763677978 0.338845449018819 0.686946959803023 0.113212921179565 0.905374486626975 -0.145017101011798 0.817309204452965 -0.0318041798322331 0.969955408199307 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FRK -0.0077672993044895 0.979338258507106 0.996036348455642 0.033956337463648 0.908561886223767 0.971429112904874 0.0056264258208955 0.988902602115371 -0.251498502290353 0.320427365919897 -0.245872076469458 0.374777269971172 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATRX -0.0034762848811471 0.97984636901279 0.996040674920114 0.0571436242467214 0.675306298516412 0.878580824298291 0.52463292551476 0.0651207470946553 -0.187386520099038 0.445278872853063 0.337246405415721 0.19487999323351 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CPXM2 -0.0124865712203116 0.979937983631788 0.996040674920114 -0.0521798033089431 0.91361403698618 0.973845229934385 0.655265710639823 1.0 0.1733822870843 0.844686202034591 0.409357661136343 0.439217930014203 0.582739948220643 0.356349123909 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SULT1C4 -0.0085950610179715 0.980226260681289 0.996040674920114 -0.194021182100901 0.529128468873806 0.806487422314082 0.287116274037313 1.0 False False False False False False False 0 insufficient_or_context_specific +CNTN4 -0.0078094698194714 0.980228179130685 0.996040674920114 0.116045125472285 0.71110154292369 0.895172301202851 False False False False False False False 0 insufficient_or_context_specific +BCKDHB 0.0076426005416974 0.980233190734791 0.996040674920114 -0.0838550590712344 0.784797092413139 0.925694079063559 0.466340713345082 1.0 -0.253359079465306 0.34025543941772 0.0016133199614434 0.996065620952593 -0.251745759503863 0.294921926256364 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TRMT11 -0.0046813491230275 0.980366244135458 0.996040674920114 -0.0694734502303139 0.715890470384983 0.897511238192495 0.0038245475171325 0.994302327353405 -0.570920058560855 0.103025106484495 -0.567095511043722 0.138303939022004 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AC002074.1 -0.0076718146841414 0.980467738866382 0.996040674920114 -0.0248680929143324 0.937453797056672 0.982785938767188 False False False False False False False 0 insufficient_or_context_specific +C8ORF33 0.0092111468818457 0.980828259785166 0.996262151215222 0.0250725692659163 0.950954531685376 0.986917609553614 True False False False False False False 0 insufficient_or_context_specific +LINC01876 0.0118961194799667 0.980881328081287 0.996262151215222 0.204913789793785 0.704535429512975 0.89229234871308 True False False False False False False 0 insufficient_or_context_specific +APPBP2 -0.0036049506209762 0.981109814453001 0.996398366775181 0.0242095960499983 0.874196495506593 0.959634705714141 -0.000750104312796 0.998543716956185 -0.317827305123218 0.271485264048571 -0.318577409436014 0.308194484685152 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TOR1AIP2 -0.0068416157359293 0.981533678630835 0.99663710126797 -0.108317091689057 0.712156485112955 0.895497343705388 -0.0514015142784645 0.868689988027735 -0.151998373816288 0.488386079129181 -0.203399888094753 0.373813820722143 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLIT3 -0.0112510970607009 0.982185595438412 0.997088076507116 0.282071916459331 0.569403054019707 0.825719070957423 1.32698085466033 0.28316522490165 0.0318385628932574 3.0 -1.57044469731659 0.160798809911724 -0.897537669600759 0.428802515744496 -2.46798236691735 0.0403033473833388 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ATRN -0.0031431774809134 0.98235988608745 0.997088076507116 0.13346193413255 0.339614702510149 0.687254194151846 0.397829281883758 1.0 -0.367262667035066 0.165705592085484 0.194628512882667 0.40050282238573 -0.172634154152399 0.486356389872667 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RARG 0.0078348824235633 0.982459401825703 0.997088076507116 -0.181317160935363 0.595997624331135 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False False False False 0 cross_species_direction_conflict +CLPX 0.0044608382924752 0.983121631157427 0.997088076507116 -0.0757629255971519 0.720089953206777 0.899728961651734 0.738371146702982 0.559692732793368 0.0661900676840343 3.0 -1.11037536064317 0.0103461786531277 0.518807230530189 0.139225834447834 -0.591568130112983 0.106277848470273 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OXR1 0.0050637266870198 0.983194510006429 0.997088076507116 0.0520503937299688 0.827415672125296 0.942259214105446 0.436556313853858 1.0 -0.221860240253872 0.431172468284317 0.415920331970021 0.0836956191378305 0.194060091716149 0.436335419197287 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GPBP1L1 -0.0031309797212919 0.983456469438937 0.997088076507116 0.0196695189804179 0.89657819548872 0.967531580672392 0.19412589687609 0.469181009611565 -0.0143464723385716 0.955099939283485 0.179779424537519 0.448173308671141 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RXYLT1 0.0052572096759448 0.983540886158691 0.997088076507116 0.0732622430479458 0.772981048749806 0.921537253014956 -0.132247367023507 0.70232485713761 -0.286487841952129 0.283105821907691 -0.418735208975637 0.145706272360995 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SC5D -0.008284219771007 0.983568836961978 0.997088076507116 -0.12817935158682 0.730102318800477 0.904213522802984 -0.391928973226987 0.299289569507709 0.695239999178556 0.0458601675163041 0.303311025951569 0.375153270629459 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RBSN -0.0035868448965876 0.983762572456057 0.997088076507116 -0.177839394970282 0.308445627671118 0.662330926800867 0.167328463736244 0.674986455385534 0.154996414289817 0.602706522860529 0.32232487802606 0.319795771820636 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CCDC150 0.0054045841643001 0.983772162623094 0.997088076507116 0.0380130678984805 0.897860844008133 0.967796120806635 0.358427457851869 1.0 True False False False False False False 0 insufficient_or_context_specific +NECAP2 -0.0048658957735016 0.984496525365691 0.997388466578742 -0.170717134687282 0.49852610241243 0.789831721078997 0.330431294702212 0.407124560143836 -0.488093191123789 0.142532836544378 -0.157661896421577 0.685035523624829 partial_or_other False False False False False False False 0 insufficient_or_context_specific +POC1B 0.0033139884284232 0.984590608722418 0.997388466578742 0.0482046523306398 0.783671866690897 0.925090291650546 -0.458608316334042 0.317934656023734 0.130310276480823 0.749265657917082 -0.328298039853219 0.428867484628924 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PDPR -0.0062820092292564 0.985105086738478 0.997388466578742 -0.217699578415359 0.517718667061417 0.800840369846825 0.610641645034082 1.0 -0.101088789580171 0.750017705646597 0.0472783894032142 0.857823368160146 -0.0538104001769565 0.85058335649462 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EIF3D 0.0046466206808914 0.985138960694552 0.997388466578742 -0.0849563689637325 0.728169033069879 0.90383360582551 0.426966308774855 1.0 -0.175226908847145 0.620394289319183 0.365123351353614 0.188908043373251 0.189896442506469 0.532746610330039 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PAK3 -0.0126931436376102 0.985171999022549 0.997388466578742 0.758076683817587 0.2208332775864 0.5925760086083 False False False False False False False 0 insufficient_or_context_specific +MOSPD2 -0.0043688142250369 0.985195304910785 0.997388466578742 0.0388086018453047 0.86974414996342 0.958502690861149 0.404166240389172 1.0 -0.0207572336840012 0.948877188830199 0.0561407007115648 0.804605796250585 0.0353834670275636 0.893807623440602 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS26 0.00588653534315 0.98530334130624 0.997388466578742 0.297960587618971 0.373960023352706 0.712264906576428 True False False False False False False 0 insufficient_or_context_specific +HSD11B1 0.0077379056665727 0.985367887708918 0.997388466578742 -0.121355126031617 0.774692285075746 0.921907331897703 1.22372405713807 0.573160646660579 2.0 -0.629995924418567 0.177305145823911 1.32629771383568 0.0087055705365661 0.696301789417111 0.11150728424137 partial_or_other False False False False False False False 0 insufficient_or_context_specific +JUNB 0.0059529064832785 0.985383474115291 0.997388466578742 -0.231976795418168 0.48752572681462 0.78238282774111 0.538253344529683 0.470987141809766 2.0 -0.489049092219281 0.155921940405771 0.101022999036076 0.754350383199834 -0.388026093183204 0.221192001575577 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANKMY2 0.0055577912468835 0.985403226329798 0.997388466578742 -0.0762927040126362 0.792797650453554 0.927620871373898 0.211552411231842 0.636705681390711 0.263535960327701 0.414520184003729 0.475088371559543 0.197312907168896 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LIN52 -0.0030158815278821 0.985526741859791 0.997388466578742 -0.126493898701413 0.441568232641672 0.758060094004529 -0.239975725922444 0.456699649785881 -0.262950405870152 0.325308427770745 -0.502926131792596 0.0881478189318564 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01238 -0.0111664347494058 0.985551462519506 0.997388466578742 -0.502539120354375 0.345334924748647 0.691144142244059 False False False False False False False 0 insufficient_or_context_specific +MAPKBP1 0.002858896925084 0.985580021956432 0.997388466578742 0.0658116049851314 0.67198145813512 0.877088599168621 -0.0431738712138021 0.936257534403958 -0.876668710841442 0.030261181733588 -0.919842582055244 0.037480318894471 partial_or_other True False False False False False False 0 cross_species_direction_conflict +AF127577.4 -0.0055743537374552 0.985678647332061 0.997392673809843 0.135897251313242 0.66399827735938 0.874384483010807 False False False False False False False 0 insufficient_or_context_specific +DIDO1 0.002168140787703 0.985915174117842 0.997455570495466 -0.0170868882530599 0.88910268269154 0.964276699808303 0.452805767780805 1.0 -0.307347432883113 0.202050363836828 -0.0627472778841677 0.783915070491109 -0.37009471076728 0.103200366856994 partial_or_other False False False False False False False 0 insufficient_or_context_specific +EED -0.0034019054311896 0.98604796359397 0.997455570495466 0.154215867837873 0.383553033371732 0.719281159207592 0.386532447407555 0.530937662198999 2.0 -0.111142142975056 0.760199212498687 0.216067452515643 0.407843424581913 0.104925309540588 0.734785657274711 partial_or_other False False False False False False False 0 insufficient_or_context_specific +INPP1 -0.0046566338425354 0.986249357185006 0.997455570495466 -0.0683251793676301 0.798077021491101 0.92925379048471 -0.109939497593633 0.834499686792016 0.53415279860977 0.124631191749373 0.424213301016137 0.26552257421949 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MRPS14 -0.0064332742298525 0.986300976743435 0.997455570495466 -0.0465112439083208 0.900230865123348 0.968057977213875 False False False False False False False 0 insufficient_or_context_specific +GPR162 0.0065286767394702 0.986307648794531 0.997455570495466 0.417438161575838 0.287829139460126 0.648229533792663 0.3603341426882029 1.0 True False False False False False False 0 insufficient_or_context_specific +FNIP2 -0.00351781399134 0.986727241488176 0.997482898926486 -0.0324198269988413 0.877691370338703 0.961221722527329 1.27968449219574 1.0 0.21646624226582 0.476990526993632 -0.31812058465323 0.199018047783419 -0.10165434238741 0.729021047120079 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SLC25A46 0.0032054482982297 0.986730836589257 0.997482898926486 0.0570368824639995 0.764025132476847 0.917095887442426 -0.400570421110422 0.285812233050116 0.14478689273796 0.664890371519158 -0.255783528372462 0.457283966028834 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SSFA2 -0.0027394988114754 0.98679432826903 0.997482898926486 -0.190551204602632 0.253052024050438 0.618991529980024 False False False False False False False 0 insufficient_or_context_specific +ZNF862 -0.0032303090468755 0.986869125290796 0.997482898926486 0.0614956452324018 0.74636686110422 0.909830759894547 False False False False False False False 0 insufficient_or_context_specific +MTIF2 -0.0039203568540306 0.986901530799969 0.997482898926486 -0.290379909309901 0.205890565578982 0.578776160707106 -0.095796821879307 0.769371208284727 -0.206005363647743 0.392973055305255 -0.301802185527051 0.242704842020139 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UNKL -0.0049054901502343 0.987089224400468 0.997577106463113 -0.415139308291154 0.147405619221349 0.532796338690088 0.919907804604881 1.0 -0.367607963213615 0.230561005523491 -0.22106483572229 0.411368029427231 -0.588672798935906 0.0507455197339353 partial_or_other False False False False False False False 0 insufficient_or_context_specific +REL -0.0062284479186742 0.987229106293343 0.997622899917553 -0.291000240250277 0.447148878544443 0.761469121135878 0.0665560866064965 0.869015643979454 -0.474509548316602 0.0932716276297516 -0.407953461710105 0.184314161126339 partial_or_other False False False False False False False 0 insufficient_or_context_specific +UBXN4 0.0022051945279776 0.987541564373851 0.997622899917553 0.0208705607905991 0.882490203540215 0.962778177759102 -0.311168229893183 0.252814360434043 0.433616447287123 0.0777772503107259 0.122448217393939 0.642649340407917 partial_or_other True False False False False False False 0 cross_species_direction_conflict +GOLGA8M 0.0052245158208432 0.987575848019937 0.997622899917553 -0.15402989981072 0.718544005552157 0.898549744197274 False False False False False False False 0 insufficient_or_context_specific +SAP30L 0.0043988931845943 0.987596327835945 0.997622899917553 0.0074365707828444 0.979101386484997 0.993800106187985 -0.182752641618495 0.621688236228168 0.373943955184866 0.196732048626877 0.191191313566371 0.548851241821563 partial_or_other True False False False False False False 0 cross_species_direction_conflict +WISP2 0.0078492431422112 0.987891578918871 0.997622899917553 0.0813987426357351 0.898123356143761 0.967796120806635 True False False False False False False 0 insufficient_or_context_specific +TMEM230 0.0029271240002698 0.987996604636029 0.997622899917553 -0.223799988264286 0.216402221660129 0.588192212595831 0.142304688953171 0.738154569148248 0.0573025755719867 0.87156074613474 0.199607264525158 0.573324965024611 partial_or_other False False False False False False False 0 insufficient_or_context_specific +STARD3 -0.0038578285359175 0.988123082396936 0.997622899917553 -0.0701352809768342 0.779049866591298 0.922987599057803 -0.0688793015828111 0.868900513081839 -0.594018754516803 0.0540311608629424 -0.662898056099615 0.0462746691067434 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MEF2D -0.0031758327510555 0.988476585369263 0.997767185394689 -0.155473061796791 0.455136744484217 0.76641675985778 0.166774399859827 0.383814595558802 2.0 0.0699754139007455 0.85512092578084 -0.245046098581644 0.358723933625841 -0.175070684680898 0.550707722524712 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NOL3 -0.0044838292563977 0.988505849519649 0.997767185394689 -0.273342889504617 0.324661310325551 0.674724889947951 0.526270453543145 1.0 -0.57478649863643 0.418655761014064 -0.61561166332032 0.322265950474667 -1.19039816195675 0.0842520662114505 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPP1R15B 0.0039051569213225 0.988679778110209 0.997847347030646 -0.100813876874181 0.756299339645263 0.914440101763119 -0.159226045950676 0.63265128930417 0.370927484583917 0.154878025399681 0.211701438633241 0.446440468399632 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MKRN1 0.0031693752012812 0.988970647362542 0.997950118976748 -0.14930366897526 0.513598845329325 0.798491683514042 -0.0120375011238135 0.985691712881774 -0.0108466501684271 0.982972032467422 -0.0228841512922406 0.967604312744424 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ENPP2 0.0064724298620725 0.989277120084541 0.99810269247395 0.263317946489589 0.565176852094298 0.823754286312897 0.453984837672706 1.0 -0.835731050619084 0.112424463035024 0.942838261869499 0.0500689047561428 0.107107211250415 0.841287709067964 partial_or_other True False False False False False False 0 cross_species_direction_conflict +LMF1 -0.0022864480791524 0.989310918425828 0.99810269247395 -0.0334962985419205 0.844535402883884 0.951003069928333 0.282834382545567 0.714710027994927 2.0 -0.649802717914746 0.009009562840796 0.397792272493025 0.0540311608629424 -0.252010445421721 0.218531409801287 reversed False False False False False False False 0 insufficient_or_context_specific +RABL2A 0.0028737298693514 0.989549439795519 0.998150694622828 0.0167674212908272 0.942050819238781 0.984366565940656 True False False False False False False 0 insufficient_or_context_specific +CNTFR 0.0064522721759712 0.989973081833755 0.998150694622828 -0.0551004677683758 0.910853667143324 0.972178833168137 0.4411228878715829 1.0 -0.521682004282739 0.400577569157124 1.15122474858108 0.0308307222802141 0.629542744298339 0.228093847586404 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PEA15 -0.0055399650960202 0.989999452527341 0.998150694622828 -0.0543873158331098 0.899361486472928 0.967837995533705 False False False False False False False 0 insufficient_or_context_specific +LINC01355 -0.0037169709868982 0.990078165074796 0.998150694622828 0.183283871370183 0.534894572855192 0.810930391494977 False False False False False False False 0 insufficient_or_context_specific +USF1 -0.004672893882911 0.990253239812077 0.998150694622828 -0.286623217165976 0.452019690951126 0.764220781091034 -0.110779493416952 0.716850600131106 -0.163851092552872 0.48948076456853 -0.274630585969825 0.269401439253753 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PATL1 0.0031724923374927 0.99041742961283 0.998150694622828 0.159484115965992 0.530284729114998 0.807433828958199 -0.0536307565066128 0.848129791979594 -0.428164452777389 0.0425463636841992 -0.481795209284002 0.0342138224306837 partial_or_other True False False False False False False 0 cross_species_direction_conflict +SAT2 -0.0030335150299598 0.990460859450533 0.998150694622828 -0.119408418163005 0.625575273486253 0.856624485564009 0.0916476732924841 0.846388159848326 -0.497765366515998 0.129476918585449 -0.406117693223514 0.259187976736181 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZNF559-ZNF177 0.0039856889391928 0.990481944766149 0.998150694622828 0.126758902538996 0.685045956407843 0.883169000123458 True False False False False False False 0 insufficient_or_context_specific +CEP70 -0.0027724927323654 0.990539731772299 0.998150694622828 -0.0319174883549338 0.889202306244899 0.964276699808303 0.432153223053564 1.0 -0.168890120216543 0.784947378045873 -0.546404666969041 0.229720873689483 -0.715294787185584 0.159326462641344 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RERE -0.0019136164439684 0.990587514515816 0.998150694622828 -0.0285169083908698 0.859486290016117 0.956914759994669 1.04931224867758 0.345696674715234 2.0 0.037100387100948 0.923414619412937 -0.308451077482072 0.236850354365092 -0.271350690381124 0.324729360238001 partial_or_other False False False False False False False 0 insufficient_or_context_specific +FAM234B 0.0043763696033075 0.991040229849614 0.998248729595712 0.290840160874619 0.544747277291303 0.815113627216777 -0.256759884254248 0.459964512056431 0.262284887435502 0.35505938977401 0.0055250031812534 0.988038906303874 partial_or_other True False False False False False False 0 cross_species_direction_conflict +OSBPL1A 0.0031003266509351 0.991204335200153 0.998248729595712 0.194269221579625 0.486880140304586 0.782147598778917 0.3747982142667671 1.0 -0.401564591281716 0.324436742651235 0.731116765070134 0.0478754039863778 0.329552173788418 0.368061746006152 partial_or_other True False False False False False False 0 cross_species_direction_conflict +PLAUR -0.0070156949620644 0.991209254458517 0.998248729595712 0.365321099291792 0.482013574422853 0.780666906162311 1.96198012816713 0.0381438028058395 -1.01034469809011 0.114153228084674 0.951635430077022 0.308324955318486 reversed False False False False False False False 0 insufficient_or_context_specific +NUPL2 -0.0018626587957258 0.991278486758395 0.998248729595712 -0.103031394384404 0.542624011788858 0.81436024398959 -0.272543364444314 0.619984737763936 0.0645908716849586 0.893908278737451 -0.207952492759355 0.672367270763274 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MYOM1 -0.0034671986208469 0.991386161342066 0.998248729595712 -0.148232029750463 0.641659841139918 0.864815393882559 0.734656406479417 0.487697845744005 0.21703960885912 0.763848495620453 0.951696015338537 0.288420638167096 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SGIP1 -0.0062961105784181 0.991493447071143 0.998248729595712 0.0110722696184895 0.985013986560108 0.995289278409573 0.271986360847774 1.0 -0.0031480101049512 0.997530093382209 -0.159354799446163 0.837209613726761 -0.162502809551114 0.863699099296708 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MAPK14 -0.0016330925231277 0.991627839136944 0.998248729595712 -0.0567910609347565 0.706014010124057 0.892947759038953 0.77600054434643 1.0 -0.22300567518816 0.357476090978652 0.0712672276052559 0.748359761018819 -0.151738447582904 0.496631791043646 partial_or_other False False False False False False False 0 insufficient_or_context_specific +AL049875.1 0.0028070599873083 0.991628647798855 0.998248729595712 0.0142255009634279 0.963655305934471 0.989935386867005 True False False False False False False 0 insufficient_or_context_specific +CMTR2 -0.0033768761858591 0.991758957403369 0.998248729595712 -0.0860844163867903 0.790976467541425 0.927588847807277 False False False False False False False 0 insufficient_or_context_specific +RAB11B-AS1 -0.0031807193818247 0.991805831802252 0.998248729595712 -0.279708517657786 0.329337838471136 0.678186271926176 False False False False False False False 0 insufficient_or_context_specific +WDR44 -0.0016980997593743 0.991815814174181 0.998248729595712 -0.0404240187592816 0.806246287550499 0.932788199072101 0.294445842887516 0.3955403941374 -0.0152952508532459 0.961891143188189 0.27915059203427 0.369881370327812 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SMG1 -0.0013377895519034 0.991890991054382 0.998248729595712 0.172004656676507 0.171645264425342 0.552641842639707 0.286986003830552 0.0748021863516467 2.0 0.347730614073633 0.225618105407407 -0.322953628609896 0.197602169436125 0.0247769854637371 0.93677237373711 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LRSAM1 0.0026265584999378 0.992018789495694 0.998248729595712 0.0158029123893955 0.951419315342338 0.986917609553614 -0.183737313797481 0.624157902569383 -0.26120839283972 0.37194472091246 -0.444945706637201 0.165482169768914 partial_or_other True False False False False False False 0 cross_species_direction_conflict +ALDOB -0.0052985331789614 0.992089014905602 0.998248729595712 0.0398652919406097 0.940508702255315 0.984034375028403 -0.255000189470721 0.73801113730009 1.20568068970036 0.0541904385029685 0.950680500229634 0.125880025238428 partial_or_other False False False False False False False 0 insufficient_or_context_specific +LINC01950 0.0069222460595604 0.992197591246202 0.998248729595712 -0.0202320454548843 0.979378509447615 0.99387526939138 False False False False False False False 0 insufficient_or_context_specific +SLC25A17 0.0015492177819139 0.992569065171255 0.998432182743722 -0.0481494397999582 0.769915197297368 0.920562318243211 -0.0624504146054065 0.836933962693437 0.415931904764038 0.0610229664477413 0.353481490158631 0.120258336035446 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CTBP2 -0.0015796275485117 0.992686828619727 0.998455514581983 -0.0077657463004703 0.963905161880038 0.989935386867005 0.7218527435772472 0.8436165937917159 2.0 0.0240312532650025 0.940338218920355 -0.124620089985916 0.568170340392869 -0.100588836720914 0.681442271047326 partial_or_other False False False False False False False 0 insufficient_or_context_specific +OLA1 0.0018638296494173 0.993238088691915 0.998802939052278 0.211964048204722 0.322352503071777 0.672877524535327 -0.252645870849063 0.531319176920206 0.369268709540492 0.247965858686076 0.116622838691429 0.757789497821365 partial_or_other True False False False False False False 0 cross_species_direction_conflict +MYH9 0.0017993181768814 0.993388857915394 0.998802939052278 -0.142362820177741 0.518671544691788 0.800840369846825 0.559005547302021 0.745782034685096 2.0 0.470358647837363 0.10586200503813 -0.723545133528297 0.0143335975597541 -0.253186485690934 0.348514773341136 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TLK2 -0.0010437089218865 0.993507793616094 0.998802939052278 -0.0019241818394228 0.987979001663972 0.996663701468395 0.583376315886467 1.0 -0.205047442030013 0.514420702075671 -0.142901202219522 0.586275275667026 -0.347948644249536 0.202743070826249 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PRMT7 -0.0020854728762724 0.993612121759583 0.998802939052278 -0.140877131092096 0.57794838793509 0.830766382548493 0.640643906362165 0.0877634096686323 -0.585147637092167 0.0685766344139705 0.0554962692699974 0.893936217470598 reversed False False False False False False False 0 insufficient_or_context_specific +COIL -0.0020172997484368 0.9936944565074 0.998802939052278 0.12165160920674 0.586745168145746 0.835274227991216 -0.0794715854176511 0.886337907728528 -0.511427035819514 0.177998059936021 -0.590898621237166 0.16305611973204 partial_or_other False False False False False False False 0 insufficient_or_context_specific +DESI1 0.001724181507958 0.993969935873707 0.998810782438303 0.0495334753728581 0.850013804313407 0.953127856970211 0.4988046580111439 0.00742419046341388 2.0 -0.549339677943503 0.0518877168173627 0.4608667894521 0.0636840018248741 -0.0884728884914031 0.747504020879527 reversed True False False False False False False 0 cross_species_direction_conflict +CDH2 -0.0029202915401899 0.994006426525525 0.998810782438303 0.543816051149497 0.155159796934229 0.539558215777 0.329843842702719 0.400734942390174 2.0 -0.256703680749182 0.304562831271428 0.17293455713158 0.428049490012478 -0.0837691236176026 0.734870543265013 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CYB561A3 -0.0027189092547688 0.994040336400727 0.998810782438303 0.0214743131057641 0.95191009079251 0.986917609553614 0.367398740561288 1.0 0.44755724633025 0.105385249647223 -0.337762881808209 0.15269870047669 0.109794364522041 0.692559346406903 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KYNU -0.0031622143646557 0.99431553481632 0.998810782438303 -0.0737796441354359 0.86476720754532 0.958391272020028 -2.3019107531816 0.0010319893141252 1.58066430713175 0.0066859463768644 -0.721246446049855 0.131398574200805 reversed False False False False False False False 0 insufficient_or_context_specific +SLC9A7 -0.0018969154430187 0.994321199689875 0.998810782438303 -0.250322555936935 0.599796594559977 0.843257280459236 False False False False False False False 0 insufficient_or_context_specific +PDCD6 -0.0012981829240375 0.994602309183025 0.998810782438303 -0.221294789889723 0.22676470676536 0.599150046792164 -0.573583834982503 0.0713899672314016 0.92680815164563 0.0063434857240439 0.353224316663127 0.216959511603848 reversed False False False False False False False 0 insufficient_or_context_specific +PIDD1 0.0019267817438509 0.99460768094663 0.998810782438303 -0.276998459607628 0.514734709301543 0.798848899133572 -0.0184795522137237 0.981425872793236 -0.533264138879994 0.303293042236316 -0.551743691093718 0.357642399894485 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ANXA6 0.0017189058228953 0.994648282492548 0.998810782438303 -0.191545904215483 0.450756074865431 0.763947905803589 0.186631786666826 0.505492777197539 0.184619892787394 0.42443397442633 0.371251679454219 0.130479285637405 partial_or_other False False False False False False False 0 insufficient_or_context_specific +C1ORF35 0.0015412512076733 0.994881214801209 0.998868638976966 0.111991428007577 0.74752513261804 0.909830759894547 0.5036011544318401 1.0 True False False False False False False 0 insufficient_or_context_specific +ZNF81 0.0015275799892336 0.995063504144487 0.998868638976966 0.257299821769824 0.336226216843255 0.684718759551425 0.6280942123611489 1.0 True False False False False False False 0 insufficient_or_context_specific +ITGAL 0.0025133909110123 0.9952136859277 0.998868638976966 -0.0828116536779378 0.873837897022555 0.959366781751097 1.2652901349255 0.04250667522668 -0.409167685558856 0.356449827270623 0.856122449366639 0.141727446607445 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TYW1 -0.0009520254125035 0.99534171453133 0.998868638976966 0.0784870742374406 0.634342868024445 0.861847932958146 0.244795075605971 0.346469590136352 -0.351692758998086 0.115239584630913 -0.106897683392115 0.675147961711509 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ERCC6L2 -0.0009025515536426 0.995437405597567 0.998868638976966 0.0510964767951868 0.747441685618524 0.909830759894547 0.372289869811609 0.369000186454962 2.0 0.144059615228291 0.68922647874159 -0.0454344389350922 0.882263502119439 0.0986251762931988 0.763439294060517 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PNPLA7 -0.0023355141071583 0.995820535289383 0.998868638976966 -0.235550754401492 0.581602387212765 0.83332444054994 -0.328924084311255 0.529896447991447 0.513128438194328 0.212704851529061 0.184204353883072 0.699290469124268 partial_or_other False False False False False False False 0 insufficient_or_context_specific +CD276 -0.0030156410657008 0.995852042568034 0.998868638976966 -0.132224078529565 0.733776769876595 0.904837086703701 1.04015112628814 0.0707535201116521 -1.19110904007555 0.021689696472548 -0.150957913787415 0.816722480292223 reversed False False False False False False False 0 insufficient_or_context_specific +TEX14 -0.0019044235428991 0.995959938169067 0.998868638976966 -0.0108631456025329 0.978101525030156 0.993500350721674 0.758171583537149 1.0 False False False False False False False 0 insufficient_or_context_specific +RBAK-RBAKDN -0.0008194892508409 0.995982689325439 0.998868638976966 0.229193461918485 0.156320065390513 0.539558215777 False False False False False False False 0 insufficient_or_context_specific +ADCY6 0.0010460486825166 0.99603955084031 0.998868638976966 -0.0064252751323579 0.977728885317127 0.993500350721674 0.556553575653857 0.036746971221705 -0.698340093916205 0.0089561881446034 -0.141786518262348 0.575606825383499 reversed False False False False False False False 0 insufficient_or_context_specific +ANP32B -0.0010950966536401 0.996110008797664 0.998868638976966 0.037809243609997 0.857447452090661 0.956914759994669 0.261144423246761 0.401056633985835 -0.606134905800503 0.0322730862911399 -0.344990482553742 0.224325874006818 partial_or_other False False False False False False False 0 insufficient_or_context_specific +PPIE -0.0033627933596834 0.996241123980778 0.998890198194592 -0.0427124742004386 0.897719311865602 0.967796120806635 0.604124377095961 1.0 -0.0506307596041238 0.899523245878635 -0.115850687916464 0.68063999196954 -0.166481447520588 0.581271452691796 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SUCLG2-AS1 -0.0009834108509169 0.997131539345599 0.999489555942382 -0.187579780593637 0.473314719307212 0.776002191970296 False False False False False False False 0 insufficient_or_context_specific +VPS50 0.0006349837335753 0.997345456314789 0.999489555942382 0.140623315946726 0.464499206176863 0.77000826170754 -0.306188599748666 0.383450708707349 -0.232175245676213 0.434170859625625 -0.538363845424879 0.0997633786731953 partial_or_other True False False False False False False 0 cross_species_direction_conflict +HARS -0.0010357288580117 0.997409541971021 0.999489555942382 -0.0248126124688527 0.924853228429723 0.978480541854262 0.0477563295368595 1.0 -0.209106755999688 0.52206945977619 0.288592269387927 0.270279903399994 0.0794855133882393 0.798833221094232 partial_or_other False False False False False False False 0 insufficient_or_context_specific +USF3 0.0004607475550743 0.99744949828515 0.999489555942382 0.0559961902892449 0.731298005433857 0.904431845923655 -0.532094142408707 0.0661828209111223 0.652402925125365 0.0194372208327657 0.120308782716659 0.666043360827916 reversed True False False False False False False 0 cross_species_direction_conflict +G3BP1 -0.0006098066855518 0.997508468788688 0.999489555942382 0.227507083813922 0.236766948991991 0.605329180588419 0.651214246779794 0.0494612528890035 -0.21100884647517 0.439538862002694 0.440205400304624 0.14586639217547 partial_or_other False False False False False False False 0 insufficient_or_context_specific +KCTD1 0.0010434981182809 0.997578512870195 0.999489555942382 -0.185382254025956 0.558498404284218 0.821540505706147 False False False False False False False 0 insufficient_or_context_specific +CITED2 -0.0016510674923034 0.997662397562869 0.999489555942382 -0.156467026672054 0.726924580479406 0.903365569206837 0.265594224600316 1.0 -0.0224139997798102 0.963968139370497 0.331201433265057 0.324028385324035 0.308787433485247 0.38816829598517 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ITGA5 0.0008128109768976 0.997774034304513 0.999489555942382 -0.222626020532088 0.562134442046877 0.823449796992147 0.0904604588764623 0.841580584933264 -0.436588978758486 0.169451520499313 -0.346128519882024 0.308359197797335 partial_or_other False False False False False False False 0 insufficient_or_context_specific +YIPF2 3.82500723419677e-05 0.997882255764976 0.999489555942382 0.0492837645031083 0.868471866625593 0.958502690861149 0.8411007438635129 1.0 -0.218630345786592 0.528737634871091 -0.0075473849432311 0.98218314043307 -0.226177730729823 0.454803069281063 partial_or_other True False False False False False False 0 cross_species_direction_conflict +FAM92A -0.0006044804734938 0.997961551003509 0.999489555942382 0.340045081044755 0.223450159397226 0.594403321470373 0.453633709691036 0.192174733359028 -0.65407432560369 0.0403841792886706 -0.200440615912654 0.55768605566137 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MOSMO -0.0006913754950344 0.99797489095895 0.999489555942382 -0.106524269916199 0.697574890935477 0.88884814126198 0.7860032412722041 1.0 0.409445543620497 0.147361329998654 -0.633533729140793 0.0212389429329446 -0.224088185520296 0.397429853125578 partial_or_other False False False False False False False 0 insufficient_or_context_specific +RAMP3 0.0012392345027296 0.998198590087848 0.999523967578481 -0.767854563152032 0.268374827213736 0.632477996813086 False False False False False False False 0 insufficient_or_context_specific +C19ORF44 0.0010971004470967 0.998342581096825 0.999547722001849 0.0073632604468726 0.979751897741216 0.993967573397882 0.510512228676956 1.0 True False False False False False False 0 insufficient_or_context_specific +RECQL -0.0003322299872113 0.99869163450512 0.999547722001849 -0.158545235550986 0.405854625220732 0.733444811508554 0.032494966221257 0.95512828581482 -0.72117970816918 0.0742923726503013 -0.688684741947923 0.111010998081844 partial_or_other False False False False False False False 0 insufficient_or_context_specific +MUS81 -0.0001153406773068 0.998978334108536 0.999547722001849 -0.0780505210962776 0.736117428563264 0.905819092164445 0.205465926196441 0.268968347187217 2.0 -0.236061256914696 0.492263523369573 -0.492897537467042 0.092406311194928 -0.728958794381738 0.0301515177113284 partial_or_other False False False False False False False 0 insufficient_or_context_specific +SUN2 0.0002963370996281 0.999049968584217 0.999547722001849 -0.288940202674754 0.496404660703436 0.788482083301772 0.7016593502945861 1.0 0.0015745152792558 0.99699280592687 0.200530318085002 0.508982574672744 0.202104833364258 0.539821382220508 partial_or_other False False False False False False False 0 insufficient_or_context_specific +TBC1D5 -0.0002160550839547 0.999095318553677 0.999547722001849 0.0865368900635962 0.647896711207531 0.86855377695836 0.0020600759529956 0.995740876664603 0.0480990060011811 0.848903648456232 0.0501590819541767 0.858029951144203 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ACAA1 0.0002333086576078 0.999215260666514 0.999547722001849 0.119065004685986 0.742197250403321 0.909062479090285 True False False False False False False 0 insufficient_or_context_specific +DDHD2 -0.0001755240416741 0.999263705789876 0.999547722001849 0.165041020113749 0.424492032208288 0.745597550499934 0.326242077685951 0.494647437884736 0.114206949782978 0.777795174750436 0.440449027468929 0.287754768720418 partial_or_other False False False False False False False 0 insufficient_or_context_specific +NAT9 -0.0002414827293718 0.999476992858599 0.999666359473389 0.281438851244081 0.329972359468337 0.678451445232074 -0.478097267227017 0.2122522298672 0.376084944358548 0.251929281001499 -0.102012322868469 0.792871789850276 partial_or_other False False False False False False False 0 insufficient_or_context_specific +ZIM2 0.0003757747792558 0.999640165777638 0.999734855572635 0.255010674235562 0.65692909038606 0.871684912617742 True False False False False False False 0 insufficient_or_context_specific +PTK2B -0.0002045834572238 0.999914404006746 0.999914404006746 -0.0631197547117225 0.854568362157673 0.955270806528397 -0.765164472569376 0.0095142747517041 0.449207032789478 0.0645580765788678 -0.315957439779898 0.194062992971038 reversed False False False False False False False 0 insufficient_or_context_specific diff --git a/data/flow_aggregate/flow_analysis_summary.json b/data/flow_aggregate/flow_analysis_summary.json new file mode 100644 index 0000000..7716566 --- /dev/null +++ b/data/flow_aggregate/flow_analysis_summary.json @@ -0,0 +1,27 @@ +{ + "n_rows_original": 450, + "n_complete_panels": 75, + "n_patients": 59, + "n_repeated_patients": 8, + "max_panels_per_patient": 7, + "context_counts": [ + { + "context": "acute-inflammatory", + "panels": 38, + "patients": 34 + }, + { + "context": "metabolic-dominant", + "panels": 16, + "patients": 15 + }, + { + "context": "oncology/hematology", + "panels": 21, + "patients": 10 + } + ], + "median_ratio_relative_error": 0.0014677011996047803, + "n_liver_stiffness_links_90d": 1, + "role_in_manuscript": "Independent real-world peripheral immune-state atlas and longitudinal supplement; not a fibrosis-stage association cohort." +} diff --git a/data/flow_aggregate/flow_context_counts.tsv b/data/flow_aggregate/flow_context_counts.tsv new file mode 100644 index 0000000..bb77cac --- /dev/null +++ b/data/flow_aggregate/flow_context_counts.tsv @@ -0,0 +1,4 @@ +context panels patients +acute-inflammatory 38 34 +metabolic-dominant 16 15 +oncology/hematology 21 10 diff --git a/data/flow_aggregate/flow_context_models.tsv b/data/flow_aggregate/flow_context_models.tsv new file mode 100644 index 0000000..e8641f3 --- /dev/null +++ b/data/flow_aggregate/flow_context_models.tsv @@ -0,0 +1,13 @@ +marker comparison beta_sd se ci_low ci_high p_value fdr +CD16+CD56+ acute-inflammatory vs metabolic-dominant -0.14666006396148593 0.2683339857510778 -0.6725946760335983 0.37927454811062655 0.5846824883915371 0.7016189860698445 +CD16+CD56+ oncology/hematology vs metabolic-dominant 0.39061227244963154 0.5442039687442578 -0.6760275062891139 1.4572520511883769 0.472900258640613 0.6305336781874841 +CD3+ acute-inflammatory vs metabolic-dominant -0.25835179272717246 0.16892402605766038 -0.5894428838001868 0.07273929834584186 0.12616621111370663 0.2530883277172732 +CD3+ oncology/hematology vs metabolic-dominant 1.2260139487029411 0.4051150350145328 0.4319884800744569 2.020039417331425 0.002475376001673465 0.00990150400669386 +CD3+CD4+ acute-inflammatory vs metabolic-dominant -0.27342138760708357 0.21135316577450636 -0.6876735925251161 0.14083081731094887 0.19577920698013718 0.2999190057245083 +CD3+CD4+ oncology/hematology vs metabolic-dominant 0.8529401575698635 0.3742020068510532 0.11950422414179929 1.5863760909979279 0.022645821470844794 0.06793746441253438 +CD3+CD8+ acute-inflammatory vs metabolic-dominant -0.20939837620297766 0.1633748077766457 -0.5296129994452032 0.11081624703924789 0.19994600381633887 0.2999190057245083 +CD3+CD8+ oncology/hematology vs metabolic-dominant 1.358370740463045 0.3989901587400898 0.5763500293324689 2.140391451593621 0.0006627998104214205 0.003976798862528523 +CD3-CD19+ acute-inflammatory vs metabolic-dominant 0.6010576608864046 0.3933951347741961 -0.16999680327101974 1.3721121250438288 0.1265441638586366 0.2530883277172732 +CD3-CD19+ oncology/hematology vs metabolic-dominant -0.06976535880566462 0.49579341396348237 -1.04152045017409 0.9019897325627608 0.888095431640763 0.888095431640763 +CD4/CD8 acute-inflammatory vs metabolic-dominant 0.07430360348005514 0.24762790542135202 -0.4110470911457948 0.5596542981059051 0.7641302369214281 0.8335966220961034 +CD4/CD8 oncology/hematology vs metabolic-dominant -1.1588741362064725 0.3338874938701162 -1.8132936241919002 -0.5044546482210448 0.0005188095134174992 0.003976798862528523 diff --git a/data/flow_aggregate/flow_immune_pca_loadings.tsv b/data/flow_aggregate/flow_immune_pca_loadings.tsv new file mode 100644 index 0000000..ac4138d --- /dev/null +++ b/data/flow_aggregate/flow_immune_pca_loadings.tsv @@ -0,0 +1,7 @@ +marker PC1_loading PC2_loading PC1_variance PC2_variance +CD16+CD56+ 0.3435771419667596 0.21890031810136512 0.5758240821530478 0.20958446850518841 +CD3+ 0.524861739062599 -0.02003679820691326 0.5758240821530478 0.20958446850518841 +CD3+CD4+ 0.47527101108561665 0.19287177835602803 0.5758240821530478 0.20958446850518841 +CD3+CD8+ 0.5247848265118491 -0.15645000262682246 0.5758240821530478 0.20958446850518841 +CD3-CD19+ 0.1346217553330677 0.7376073347165512 0.5758240821530478 0.20958446850518841 +CD4/CD8 -0.29507666336354843 0.588167043463787 0.5758240821530478 0.20958446850518841 diff --git a/data/mechanism_summary/GSE295293_exact_phase_tests.tsv b/data/mechanism_summary/GSE295293_exact_phase_tests.tsv new file mode 100644 index 0000000..06dd9f7 --- /dev/null +++ b/data/mechanism_summary/GSE295293_exact_phase_tests.tsv @@ -0,0 +1,10 @@ +outcome contrast effect exact_two_sided_p exact_directional_p n_assignments +resolver_axis progression 1.8517825485074735 0.004164187983343248 0.002379535990481856 1680 +resolver_axis withdrawal -0.4113883868762583 0.5823914336704342 0.2914931588340274 1680 +resolver_axis residual 1.4403941616312153 0.042236763831052945 0.021415823914336704 1680 +lock_axis progression 1.4121560803037632 0.006543723973825104 0.003569303985722784 1680 +lock_axis withdrawal -0.6569694957746913 0.32540154669839383 0.16299821534800712 1680 +lock_axis residual 0.7551865845290717 0.2552052349791791 0.12790005948839978 1680 +control_imbalance progression -0.3108628568559357 0.3075550267697799 0.15407495538370017 1680 +control_imbalance withdrawal -0.17365206743339404 0.5728732897085068 0.2867340868530637 1680 +control_imbalance residual -0.4845149242893297 0.06841165972635337 0.034503271861986914 1680 diff --git a/data/mechanism_summary/LINCS_ordered_basin_switch_pairs.tsv b/data/mechanism_summary/LINCS_ordered_basin_switch_pairs.tsv new file mode 100644 index 0000000..555aa9c --- /dev/null +++ b/data/mechanism_summary/LINCS_ordered_basin_switch_pairs.tsv @@ -0,0 +1,300 @@ +early_compound late_compound forward_score reverse_score order_advantage early_mean_resolver early_resolver_floor early_retention late_retention late_q25_retention late_resolver_floor early_tier late_tier both_named both_hard_gate forward_percentile order_percentile basin_switch_index basin_switch_rank +ezetimibe aliskiren 0.991250659782617 0.4635385405493989 0.527712119233218 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9832775919732442 0.9832775919732442 0.9832775919732442 1 +ezetimibe prednisone 0.9586663077888448 0.41124356563188247 0.5474227421569623 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9732441471571907 0.9966555183946488 0.981438127090301 2 +r(-)-propylnorapomorphine aliskiren 0.9556010816660192 0.421358848153244 0.5342422335127752 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9698996655518395 0.9899665551839465 0.976923076923077 3 +panobinostat prednisone 0.9964218039826918 0.5280599711566335 0.46836183282605826 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.9866220735785953 0.939799331103679 0.9702341137123747 4 +panobinostat aliskiren 1.029006155976464 0.58035494607415 0.4486512099023141 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.9966555183946488 0.9163879598662207 0.968561872909699 5 +r(-)-propylnorapomorphine prednisone 0.9230167296722471 0.36906387323572754 0.5539528564365196 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9431438127090301 1.0 0.9630434782608696 6 +ezetimibe psb-069 1.0094935946935226 0.5710814891102176 0.438412105583305 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.9933110367892977 0.8996655518394648 0.9605351170568561 7 +r(-)-propylnorapomorphine psb-069 0.9738440165769249 0.5289017967140627 0.4449422198628622 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.979933110367893 0.9096989966555183 0.9553511705685618 8 +stk-249718 aliskiren 0.9182493440836432 0.39761467224046126 0.520634671843182 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9364548494983278 0.979933110367893 0.9516722408026757 9 +ezetimibe bromocriptine 0.9102166814171517 0.4344725208643396 0.47574416055281216 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9331103678929766 0.9498327759197325 0.9389632107023411 10 +stk-249718 psb-069 0.9364922789945489 0.5051576208012799 0.431334658193269 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.9565217391304348 0.8896321070234113 0.9331103678929766 11 +ezetimibe pd-0325901 0.9036995703834922 0.4199196235350673 0.48377994684842496 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9163879598662207 0.9632107023411371 0.9327759197324414 12 +stk-249718 prednisone 0.8856649920898712 0.34531969732294476 0.5403452947669264 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8929765886287625 0.9933110367892977 0.9280936454849498 13 +thiostrepton aliskiren 0.8916110471186658 0.3982615905207776 0.4933494565978882 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.8996655518394648 0.9698996655518395 0.9242474916387959 14 +panobinostat pd-0325901 0.9414550665773392 0.5367360290598184 0.4047190375175208 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.959866220735786 0.8528428093645485 0.9224080267558529 15 +panobinostat bromocriptine 0.9479721776109987 0.5512889263890906 0.3966832512219082 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.9665551839464883 0.8361204013377926 0.9209030100334448 16 +y-26763 prednisone 0.8770943327016003 0.3436154609339103 0.5334788717676899 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_3_computational_hit Tier_4_not_prioritized True False 0.8795986622073578 0.9866220735785953 0.9170568561872909 17 +y-26763 aliskiren 0.9096786846953725 0.47322606065473144 0.43645262404064106 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_3_computational_hit Tier_4_not_prioritized True False 0.9264214046822743 0.8929765886287625 0.9147157190635452 18 +panobinostat psb-069 1.0472490908873695 0.6878978946349686 0.35935119625240086 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True True 1.0 0.7290969899665551 0.9051839464882943 19 +r(-)-propylnorapomorphine bromocriptine 0.874567103300554 0.39229282846818464 0.48227427483236934 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8729096989966555 0.959866220735786 0.9033444816053512 20 +thiostrepton psb-069 0.9098539820295715 0.5058045390815962 0.4040494429479753 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True False 0.9297658862876255 0.842809364548495 0.8993311036789298 21 +r(-)-propylnorapomorphine pd-0325901 0.8680499922668945 0.3777399311389124 0.4903100611279821 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.862876254180602 0.9665551839464883 0.8991638795986622 22 +thiostrepton prednisone 0.8590266951248936 0.3459666156032611 0.5130600795216325 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.8528428093645485 0.9765886287625418 0.8961538461538461 23 +ezetimibe verteporfin 0.8923123237262998 0.5041988742064742 0.3881134495198255 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.9063545150501672 0.8093645484949833 0.8724080267558529 24 +ezetimibe wz-4002 0.9652742582820504 0.6285826451152504 0.33669161316679996 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.9765886287625418 0.6688963210702341 0.8688963210702341 25 +stk-249718 bromocriptine 0.837215365718178 0.36854865255540187 0.46866671316277614 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8193979933110368 0.9431438127090301 0.8627090301003344 26 +y-26763 psb-069 0.9279216196062781 0.5807690092155502 0.34715261039072787 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_3_computational_hit Tier_3_computational_hit True True 0.9464882943143813 0.6989966555183946 0.8598662207357859 27 +stk-249718 pd-0325901 0.8306982546845185 0.35399575522612964 0.4767024994583889 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8060200668896321 0.9565217391304348 0.8586956521739131 28 +r(-)-propylnorapomorphine wz-4002 0.9296246801654527 0.5864029527190955 0.34322172744635726 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.9498327759197325 0.6822742474916388 0.8561872909698997 29 +aminopentamide aliskiren 0.833238133998026 0.3769485101709882 0.45628962382703786 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8160535117056856 0.9264214046822743 0.8546822742474917 30 +ezetimibe nvp-tae684 0.9061188932826063 0.5477355869546059 0.3583833063280004 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.919732441471572 0.725752508361204 0.8518394648829433 31 +pre-084 prednisone 0.8450637823672935 0.4211918654304647 0.4238719169368288 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.8294314381270903 0.882943143812709 0.8481605351170568 32 +r(-)-propylnorapomorphine verteporfin 0.856662745609702 0.4620191818103194 0.3946435637993826 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.8494983277591973 0.8294314381270903 0.8424749163879599 33 +panobinostat verteporfin 0.9300678199201469 0.6210152797312254 0.3090525401889215 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True True 0.9531772575250836 0.6020066889632107 0.8302675585284282 34 +pre-084 aliskiren 0.8776481343610656 0.5214680867225286 0.35618004763853695 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.882943143812709 0.7224080267558528 0.8267558528428094 35 +r(-)-propylnorapomorphine nvp-tae684 0.8704693151660086 0.505555894558451 0.3649134206075576 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8695652173913043 0.7424749163879598 0.8250836120401337 36 +stk-249718 wz-4002 0.8922729425830767 0.5626587768063127 0.32961416577676395 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.903010033444816 0.6521739130434783 0.8152173913043478 37 +thiostrepton bromocriptine 0.8105770687532006 0.36919557083571813 0.44138149791748243 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.7625418060200669 0.903010033444816 0.811705685618729 38 +prochlorperazine aliskiren 0.8278346426991953 0.4319884201792616 0.3958462225199337 0.3393047527809228 0.148764285658087 0.0186749911970562 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.7959866220735786 0.8327759197324415 0.8088628762541805 39 +aminopentamide psb-069 0.8514810689089316 0.48449145873180693 0.36698961017712467 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.8361204013377926 0.745819397993311 0.804515050167224 40 +aminopentamide prednisone 0.8006537820042539 0.3246535352534718 0.47600024675078206 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.7224080267558528 0.9531772575250836 0.8031772575250836 41 +thiostrepton pd-0325901 0.8040599577195411 0.35464267350644596 0.4494172842130951 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.7391304347826086 0.919732441471572 0.8023411371237459 42 +panobinostat nvp-tae684 0.9438743894764533 0.664551992479357 0.27932239699709627 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.9632107023411371 0.5016722408026756 0.8016722408026756 43 +y-26763 pd-0325901 0.8221275952962478 0.42960714364039987 0.3925204516558479 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_3_computational_hit Tier_4_not_prioritized True False 0.7892976588628763 0.822742474916388 0.8010033444816054 44 +y-26763 bromocriptine 0.8286447063299074 0.44416004096967204 0.38448466536023534 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_3_computational_hit Tier_4_not_prioritized True False 0.7993311036789298 0.802675585284281 0.8005016722408027 45 +panobinostat wz-4002 1.0030297544758975 0.7453990506400014 0.25763070383589604 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True True 0.9899665551839465 0.43812709030100333 0.7968227424749165 46 +loperamide prednisone 0.8322542188947812 0.4556978701776454 0.37655634871713584 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8093645484949833 0.7692307692307693 0.7953177257525084 47 +panobinostat glycocholic-acid 0.8301217698654721 0.4582515775063445 0.37187019235912766 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.802675585284281 0.7591973244147158 0.7874581939799331 48 +stk-249718 verteporfin 0.819311008027326 0.43827500589753665 0.3810360021297894 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.782608695652174 0.7859531772575251 0.7837792642140469 49 +prochlorperazine prednisone 0.7952502907054231 0.3499372028523966 0.4453130878530265 0.3393047527809228 0.148764285658087 0.0186749911970562 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.7123745819397993 0.9130434782608695 0.7826086956521738 50 +stk-249718 nvp-tae684 0.8331175775836326 0.48181171864566824 0.35130585893796434 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8127090301003345 0.7123745819397993 0.7775919732441472 51 +ezetimibe glycocholic-acid 0.7923662736716252 0.34143517198159345 0.4509311016900317 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6989966555183946 0.9230769230769231 0.7774247491638796 52 +geldanamycin aliskiren 0.9008760851704413 0.6279409286226072 0.27293515654783407 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.9130434782608695 0.4916387959866221 0.7655518394648829 53 +ag-490 aliskiren 0.7893444688931581 0.3527509146517823 0.4365935542413758 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6889632107023411 0.8963210702341137 0.7615384615384615 54 +panobinostat pd-184352 0.8064069023304101 0.42205692930442706 0.38434997302598306 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.7424749163879598 0.7959866220735786 0.7612040133779264 55 +thiostrepton wz-4002 0.8656346456180992 0.5633056950866291 0.30232895053147013 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True False 0.8595317725752508 0.5652173913043478 0.7565217391304347 56 +pre-084 psb-069 0.8958910692719713 0.6290110352833473 0.2668800339886239 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_1_mechanistic_probe Tier_3_computational_hit True True 0.9096989966555183 0.46153846153846156 0.7528428093645485 57 +geldanamycin prednisone 0.8682917331766691 0.5714705826803331 0.29682115049633595 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.8662207357859532 0.5418060200668896 0.7526755852842809 58 +prochlorperazine psb-069 0.8460775776101009 0.5395313687400802 0.3065462088700207 0.3393047527809228 0.148764285658087 0.0186749911970562 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True True 0.8327759197324415 0.5886287625418061 0.7473244147157191 59 +ezetimibe pd-184352 0.768651406136563 0.30524052377967603 0.463410882356887 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6454849498327759 0.9364548494983278 0.7473244147157191 59 +r(-)-propylnorapomorphine glycocholic-acid 0.7567166955550275 0.25779289718244297 0.49892379837258455 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6187290969899666 0.9732441471571907 0.742809364548495 61 +ag-490 psb-069 0.8075874038040638 0.4602938632126011 0.3472935405914627 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.7591973244147158 0.7023411371237458 0.7392976588628762 62 +loperamide aliskiren 0.8648385708885533 0.5866812091054661 0.27815736178308725 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8561872909698997 0.4983277591973244 0.7309364548494983 63 +ag-490 prednisone 0.7567601168993859 0.3004559397342659 0.45630417716512006 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6220735785953178 0.9297658862876255 0.7297658862876255 64 +y-26763 wz-4002 0.883702283194806 0.6382701652205829 0.24543211797422315 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_3_computational_hit Tier_1_mechanistic_probe True True 0.8896321070234113 0.40468227424749165 0.7198996655518395 65 +thiostrepton verteporfin 0.7926727110623486 0.43892192417785303 0.35375078688449557 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True False 0.705685618729097 0.7190635451505016 0.7103678929765886 66 +ezetimibe tyrphostin-1 0.817842282310483 0.5113162649573668 0.30652601735311613 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.7759197324414716 0.5852842809364549 0.7091973244147158 67 +thiostrepton nvp-tae684 0.8064792806186551 0.4824586369259845 0.32402064369267064 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.745819397993311 0.6287625418060201 0.7048494983277591 68 +geldanamycin psb-069 0.9191190200813468 0.7354838771834258 0.18363514289792104 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True False 0.939799331103679 0.22742474916387959 0.6904682274247492 69 +r(-)-propylnorapomorphine pd-184352 0.7330018280199655 0.2630608313835211 0.4699409966364444 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5518394648829431 0.9464882943143813 0.6899665551839465 70 +aminopentamide bromocriptine 0.7522041556325608 0.34788249048592884 0.404321665146632 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6053511705685619 0.8461538461538461 0.6896321070234115 71 +arcyriaflavin-a prednisone 0.7864104255494321 0.4356065589698059 0.3508038665796262 0.25139682919585277 0.135857936926186 0.176811108055214 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6789297658862876 0.7090301003344481 0.6894648829431438 72 +y-26763 verteporfin 0.8107403486390554 0.5138863943118069 0.2968539543272485 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_3_computational_hit Tier_1_mechanistic_probe True True 0.7658862876254181 0.5451505016722408 0.688628762541806 73 +aminopentamide pd-0325901 0.7456870445989013 0.33332959315665667 0.41235745144224467 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5919732441471572 0.8662207357859532 0.6879598662207358 74 +y-26763 nvp-tae684 0.8245469181953617 0.5574231070599385 0.2671238111354233 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_3_computational_hit Tier_4_not_prioritized True False 0.7926421404682275 0.46488294314381273 0.6779264214046823 75 +arcyriaflavin-a aliskiren 0.8189947775432042 0.5461705752448843 0.27282420229831983 0.25139682919585277 0.135857936926186 0.176811108055214 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.7792642140468228 0.4882943143812709 0.6774247491638796 76 +panobinostat tyrphostin-1 0.85559777850433 0.628132670482118 0.2274651080222121 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True True 0.8461538461538461 0.3612040133779264 0.6764214046822743 77 +wz-4002 aliskiren 0.8878975514773398 0.6968770454109218 0.19102050606641807 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.8963210702341137 0.25418060200668896 0.671571906354515 78 +ezetimibe duloxetine 0.7540904474426208 0.3761590098969579 0.3779314375456629 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6120401337792643 0.7759197324414716 0.6693979933110368 79 +pre-084 bromocriptine 0.7966141559956004 0.4924020670374693 0.30421208895813107 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7157190635451505 0.5752508361204013 0.6665551839464883 80 +ezetimibe ambroxol 0.7397342591531693 0.3418128165741643 0.39792144257900497 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5719063545150501 0.8394648829431438 0.6655518394648829 81 +loperamide psb-069 0.8830815057994591 0.6942241576662849 0.18885734813317423 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.8862876254180602 0.24749163879598662 0.6627090301003344 82 +pre-084 pd-0325901 0.7900970449619409 0.4778491697081971 0.3122478752537438 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.6923076923076923 0.6053511705685619 0.6618729096989967 83 +wz-4002 prednisone 0.8553131994835677 0.6445820704934054 0.21073112899016222 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.842809364548495 0.3110367892976589 0.6566889632107024 84 +stk-249718 glycocholic-acid 0.7193649579726514 0.27551130367265575 0.4438536542999957 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5217391304347826 0.9063545150501672 0.6563545150501672 85 +ticlopidine aliskiren 0.7414480896910565 0.3614093916479587 0.38003869804309776 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5819397993311036 0.782608695652174 0.6521739130434783 86 +bibx-1382 aliskiren 0.7831141429820231 0.4674719324601547 0.31564221052186836 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6722408026755853 0.6120401337792643 0.6511705685618729 87 +ezetimibe tubocurarine 0.7220422201789916 0.3065483757028622 0.41549384447612936 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5317725752508361 0.8729096989966555 0.6511705685618729 87 +aminopentamide wz-4002 0.8072617324974596 0.5419926147368397 0.2652691177606199 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.7558528428093646 0.45484949832775917 0.6505016722408027 89 +r(-)-propylnorapomorphine tyrphostin-1 0.7821927041938853 0.46913657256121194 0.3130561316326734 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6688963210702341 0.6086956521739131 0.6478260869565218 90 +panobinostat duloxetine 0.7918459436364678 0.49297541542170886 0.2988705282147589 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.6956521739130435 0.5551839464882943 0.6464882943143813 91 +panobinostat ambroxol 0.7774897553470163 0.4586292220989153 0.31886053324810093 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.6588628762541806 0.6220735785953178 0.6459866220735786 92 +panobinostat tubocurarine 0.7597977163728387 0.42336478122761323 0.33643293514522543 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.6321070234113713 0.6655518394648829 0.6438127090301003 93 +ezetimibe atorvastatin 0.7381697335383957 0.3611505521712677 0.377019181367128 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.568561872909699 0.7725752508361204 0.6399665551839464 94 +ticlopidine prednisone 0.7088637376972843 0.2961581635939341 0.4127055741033502 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5016722408026756 0.8695652173913043 0.6304347826086956 95 +geldanamycin bromocriptine 0.819842106804976 0.5988749089375478 0.22096719786742824 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.7859531772575251 0.3411371237458194 0.6302675585284281 96 +geldanamycin pd-0325901 0.8133249957713166 0.5843220116082757 0.22900298416304088 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.7692307692307693 0.36789297658862874 0.6287625418060201 97 +prochlorperazine bromocriptine 0.7468006643337302 0.4029224004942022 0.34387826383952796 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.5953177257525084 0.6889632107023411 0.6280936454849498 98 +wz-4002 psb-069 0.9061404863882454 0.8044199939717405 0.10172049241650494 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_1_mechanistic_probe Tier_3_computational_hit True True 0.9230769230769231 0.07023411371237458 0.6245819397993312 99 +prochlorperazine pd-0325901 0.7402835533000706 0.38836950316492996 0.3519140501351406 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.5752508361204013 0.7157190635451505 0.6244147157190636 100 +stk-249718 pd-184352 0.6956500904375894 0.23931665547073838 0.456333434966851 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.45484949832775917 0.9331103678929766 0.6222408026755852 101 +bibx-1382 prednisone 0.750529790988251 0.41517695754263834 0.3353528334456127 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6020066889632107 0.6588628762541806 0.6219063545150502 102 +panobinostat atorvastatin 0.7759252297322429 0.47796695769601866 0.2979582720362242 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.6521739130434783 0.5518394648829431 0.6170568561872909 103 +r(-)-propylnorapomorphine duloxetine 0.7184408693260231 0.3339793175008029 0.38446155182522024 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5183946488294314 0.7993311036789298 0.6167224080267558 104 +pre-084 wz-4002 0.851671732860499 0.6865121912883801 0.16515954157211887 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.8394648829431438 0.1939799331103679 0.6135451505016724 105 +arcyriaflavin-a psb-069 0.8372377124541097 0.653713523805703 0.1835241886484067 0.25139682919585277 0.135857936926186 0.176811108055214 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.822742474916388 0.22408026755852842 0.6132107023411372 106 +r(-)-propylnorapomorphine ambroxol 0.7040846810365716 0.29963312417800936 0.40445155685856227 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.48494983277591974 0.8494983277591973 0.6125418060200669 107 +ag-490 bromocriptine 0.7083104905276929 0.32368489496672304 0.38462559556096987 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4983277591973244 0.8060200668896321 0.6060200668896321 108 +prednisolone-acetate aliskiren 0.7539784021986028 0.44535822486726656 0.30862017733133623 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6086956521739131 0.5986622073578596 0.6051839464882944 109 +thiostrepton glycocholic-acid 0.692726661007674 0.27615822195297207 0.4165684390547019 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.44816053511705684 0.8762541806020067 0.5979933110367892 110 +ticlopidine psb-069 0.7596910246019621 0.4689523402087774 0.29073868439318473 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.6287625418060201 0.5317725752508361 0.5948160535117057 111 +bibx-1382 psb-069 0.8013570778929286 0.5750148810209734 0.22634219687195523 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.725752508361204 0.3511705685618729 0.5946488294314382 112 +ag-490 pd-0325901 0.7017933794940333 0.3091319976374507 0.3926613818565826 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4682274247491639 0.8260869565217391 0.5934782608695652 113 +etomidate aliskiren 0.7889657141455996 0.5403857108368169 0.24858000330878272 0.2152146542710917 0.1923187635838985 0.189117331109527 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.68561872909699 0.4180602006688963 0.5919732441471571 114 +r(-)-propylnorapomorphine atorvastatin 0.7025201554217981 0.31897085977511275 0.3835492956466854 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4782608695652174 0.7926421404682275 0.5882943143812709 115 +geldanamycin wz-4002 0.8748996836698747 0.7929850331884587 0.081914650481416 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True False 0.8762541806020067 0.05016722408026756 0.5871237458193981 116 +y-26763 glycocholic-acid 0.7107942985843807 0.35112269208692604 0.35967160649745467 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_3_computational_hit Tier_4_not_prioritized True False 0.5050167224080268 0.7324414715719063 0.5846153846153845 117 +nu-7026 prednisone 0.6899139605913429 0.27947112679895414 0.4104428337923888 0.22968370221289142 0.121435706104551 0.0272444321049584 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.43478260869565216 0.862876254180602 0.5846153846153845 117 +r(-)-propylnorapomorphine tubocurarine 0.6863926420623938 0.2643686833067073 0.4220239587556865 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.42474916387959866 0.8795986622073578 0.5839464882943144 119 +nu-7026 aliskiren 0.722498312585115 0.3857473358031481 0.3367509767819669 0.22968370221289142 0.121435706104551 0.0272444321049584 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5351170568561873 0.6722408026755853 0.5831103678929765 120 +aminopentamide verteporfin 0.734299797941709 0.4176088438280637 0.3166909541136453 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5585284280936454 0.6187290969899666 0.5795986622073579 121 +etomidate prednisone 0.7563813621518275 0.47216731455502275 0.28421404759680474 0.2152146542710917 0.1923187635838985 0.189117331109527 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6153846153846154 0.5117056856187291 0.5790969899665552 122 +stk-249718 tyrphostin-1 0.7448409666115092 0.44539239664842917 0.29944856996308006 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5886287625418061 0.5585284280936454 0.5780936454849499 123 +prochlorperazine wz-4002 0.8018582411986288 0.597032524745113 0.20482571645351577 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True True 0.7290969899665551 0.28762541806020064 0.574581939799331 124 +aminopentamide nvp-tae684 0.7481063674980153 0.4611455565761952 0.2869608109218201 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5986622073578596 0.5284280936454849 0.5740802675585285 125 +prednisolone-acetate prednisone 0.7213940502048307 0.3930632499497501 0.3283308002550806 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5284280936454849 0.6488294314381271 0.5705685618729097 126 +thiostrepton pd-184352 0.669011793472612 0.23996357375105465 0.4290482197215573 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.3979933110367893 0.8862876254180602 0.568896321070234 127 +loperamide bromocriptine 0.7838045925230881 0.5576151894204067 0.22618940310268143 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6755852842809364 0.34782608695652173 0.5608695652173913 128 +loperamide pd-0325901 0.7772874814894286 0.5430622920911345 0.23422518939829406 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6555183946488294 0.3779264214046823 0.558361204013378 129 +ag-490 wz-4002 0.7633680673925916 0.5177950192176338 0.24557304817495773 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6387959866220736 0.4080267558528428 0.5580267558528429 130 +loperamide wz-4002 0.8388621693879869 0.7517253136713176 0.08713685571666929 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.8260869565217391 0.05351170568561873 0.555685618729097 131 +etomidate psb-069 0.8072086490565051 0.6479286593976354 0.1592799896588697 0.2152146542710917 0.1923187635838985 0.189117331109527 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.7525083612040134 0.1806020066889632 0.5523411371237459 132 +y-26763 pd-184352 0.6870794310493187 0.3149280438850086 0.37215138716431007 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_3_computational_hit Tier_4_not_prioritized True False 0.4280936454849498 0.7625418060200669 0.5451505016722409 133 +pre-084 verteporfin 0.7787097983047484 0.5621284203796042 0.2165813779251442 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.6622073578595318 0.3277591973244147 0.5451505016722408 134 +pre-084 nvp-tae684 0.792516367861055 0.6056651331277356 0.18685123473331933 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7023411371237458 0.2408026755852843 0.5408026755852843 135 +stk-249718 ambroxol 0.6667329434541955 0.27588894826522664 0.3908439951889689 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.391304347826087 0.8160535117056856 0.5399665551839465 136 +prednisolone-acetate psb-069 0.7722213371095085 0.5529011734280853 0.21932016368142315 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.6488294314381271 0.3311036789297659 0.5376254180602007 137 +wz-4002 bromocriptine 0.8068635731118745 0.6678110257258624 0.13905254738601214 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7491638795986622 0.13712374581939799 0.5349498327759197 138 +stk-249718 duloxetine 0.6810891317436472 0.3102351415880201 0.37085399015562703 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.41471571906354515 0.7525083612040134 0.532943143812709 139 +geldanamycin nvp-tae684 0.8157443186704305 0.7121379750278143 0.10360634364261623 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.7725752508361204 0.07692307692307693 0.5290969899665553 140 +emf-sumo1-10 aliskiren 0.6634220992407156 0.27386064726179327 0.38956145197892234 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3712374581939799 0.8127090301003345 0.525752508361204 141 +wz-4002 pd-0325901 0.8003464620782151 0.6532581283965901 0.147088333681625 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7190635451505016 0.16387959866220736 0.5247491638795986 142 +nu-7026 psb-069 0.7407412474960207 0.4932902843639667 0.24745096313205395 0.22968370221289142 0.121435706104551 0.0272444321049584 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.5785953177257525 0.41471571906354515 0.5212374581939799 143 +geldanamycin verteporfin 0.8019377491141241 0.6686012622796826 0.13333648683444144 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True False 0.7324414715719063 0.12374581939799331 0.5193979933110368 144 +stk-249718 tubocurarine 0.6490409044800178 0.24062450739392455 0.4084163970860933 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3277591973244147 0.8561872909698997 0.5127090301003344 145 +stk-249718 atorvastatin 0.6651684178394222 0.29522668386233 0.3699417339770922 0.48277351991938694 0.3056777156889438 -0.0874331403109762 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3779264214046823 0.7491638795986622 0.5078595317725753 146 +prochlorperazine nvp-tae684 0.7427028761991846 0.5161854665844685 0.22651740961471611 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.5852842809364549 0.35785953177257523 0.505685618729097 147 +prochlorperazine verteporfin 0.7288963066428782 0.472648753836337 0.2562475528065412 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True True 0.5451505016722408 0.431438127090301 0.5053511705685618 148 +thiostrepton tyrphostin-1 0.7182026696465318 0.4460393149287455 0.2721633547177863 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True False 0.5150501672240803 0.4816053511705686 0.5033444816053512 149 +arcyriaflavin-a bromocriptine 0.7379607991777389 0.5171045555598249 0.220856243617914 0.25139682919585277 0.135857936926186 0.176811108055214 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5652173913043478 0.3377926421404682 0.48561872909698994 150 +arcyriaflavin-a pd-0325901 0.7314436881440793 0.5025516582305528 0.22889202991352653 0.25139682919585277 0.135857936926186 0.176811108055214 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5484949832775919 0.36454849498327757 0.4841137123745819 151 +ag-490 nvp-tae684 0.7042127023931474 0.43694796105698935 0.267264741336158 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4882943143812709 0.4682274247491639 0.48127090301003345 152 +wz-4002 nvp-tae684 0.8027657849773292 0.7810740918161287 0.021691693161200454 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7357859531772575 0.006688963210702341 0.4806020066889632 153 +ag-490 verteporfin 0.6904061328368409 0.39341124830885776 0.29699488452798317 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.4414715719063545 0.5484949832775919 0.4789297658862876 154 +arcyriaflavin-a wz-4002 0.7930183760426377 0.7112146798107358 0.08180369623190187 0.25139682919585277 0.135857936926186 0.176811108055214 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.7090301003344481 0.046822742474916385 0.477257525083612 155 +emf-sumo1-10 prednisone 0.6308377472469434 0.22156567234427677 0.40927207490266665 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2709030100334448 0.8595317725752508 0.4769230769230769 156 +y-26763 tyrphostin-1 0.7362703072232386 0.5210037850626994 0.2152665221605392 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_3_computational_hit Tier_1_mechanistic_probe True True 0.5618729096989966 0.3177257525083612 0.47642140468227423 157 +emf-sumo1-10 psb-069 0.6816650341516213 0.38140359582261196 0.3002614383290093 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.4180602006688963 0.5618729096989966 0.4683946488294314 158 +bibx-1382 bromocriptine 0.702080164616558 0.43840591277509544 0.26367425184146254 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.47491638795986624 0.44816053511705684 0.46555183946488293 159 +ticlopidine bromocriptine 0.6604141113255912 0.33234337196289937 0.3280707393626919 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.36789297658862874 0.6454849498327759 0.4650501672240802 160 +loperamide verteporfin 0.7659002348322361 0.6273415427625415 0.13855869206969462 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6421404682274248 0.13377926421404682 0.4642140468227425 161 +thiostrepton duloxetine 0.6544508347786696 0.3108820598683365 0.3435687749103331 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.34448160535117056 0.68561872909699 0.46387959866220735 162 +y-26763 duloxetine 0.6725184723553764 0.36881423663229673 0.3037042357230797 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_3_computational_hit Tier_4_not_prioritized True False 0.4013377926421405 0.5719063545150501 0.4610367892976588 163 +bibx-1382 pd-0325901 0.6955630535828984 0.4238530154458232 0.27171003813707517 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.451505016722408 0.4782608695652174 0.4608695652173913 164 +loperamide nvp-tae684 0.7797068043885427 0.6708782555106731 0.10882854887786952 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6655518394648829 0.0802675585284281 0.4607023411371237 165 +thiostrepton ambroxol 0.6400946464892181 0.27653586654554296 0.36355877994367514 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.3010033444816054 0.7391304347826086 0.45434782608695645 166 +aminopentamide glycocholic-acid 0.6343537478870342 0.2548451416031828 0.37950860628385147 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.27759197324414714 0.7792642140468228 0.45317725752508364 167 +ticlopidine pd-0325901 0.6538970002919318 0.3177904746336271 0.3361065256583047 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3377926421404682 0.6622073578595318 0.45133779264214047 168 +wz-4002 verteporfin 0.7889592154210227 0.7375373790679973 0.05142183635302533 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.6822742474916388 0.020066889632107024 0.4505016722408027 169 +bibx-1382 wz-4002 0.7571377414814566 0.6325160370260062 0.1246217044554504 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6254180602006689 0.11036789297658862 0.44515050167224085 170 +pre-084 glycocholic-acid 0.6787637482500738 0.3993647181547232 0.2793990300953506 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.411371237458194 0.5050167224080268 0.44414715719063547 171 +y-26763 ambroxol 0.6581622840659249 0.35150033667949687 0.30666194738642805 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_3_computational_hit Tier_4_not_prioritized True False 0.3612040133779264 0.5919732441471572 0.4419732441471572 172 +thiostrepton tubocurarine 0.6224026075150404 0.24127142567424084 0.3811311818407995 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.2508361204013378 0.7892976588628763 0.43929765886287625 173 +aminopentamide pd-184352 0.6106388803519722 0.21865049340126538 0.3919883869507068 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.22742474916387959 0.8193979933110368 0.4346153846153846 174 +thiostrepton atorvastatin 0.6385301208744447 0.29587360214264624 0.3426565187317985 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.2976588628762542 0.6789297658862876 0.43110367892976587 175 +etomidate wz-4002 0.7629893126450331 0.7054298154026684 0.057559497242364754 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6354515050167224 0.033444816053511704 0.42474916387959866 176 +ticlopidine wz-4002 0.7154716881904899 0.5264534962138102 0.18901819197667968 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5117056856187291 0.2508361204013378 0.42040133779264216 177 +y-26763 tubocurarine 0.6404702450917472 0.3162358958081948 0.32423434928355244 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_3_computational_hit Tier_4_not_prioritized True False 0.30434782608695654 0.6321070234113713 0.4190635451505017 178 +pre-084 pd-184352 0.6550488807150118 0.36317006995280576 0.291878810762206 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.3511705685618729 0.5351170568561873 0.41555183946488294 179 +etomidate bromocriptine 0.7079317357801345 0.5113196911517575 0.196612044628377 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.49498327759197325 0.26755852842809363 0.4153846153846154 180 +prednisolone-acetate bromocriptine 0.6729444238331376 0.4162922051822072 0.25665221865093035 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.40468227424749165 0.43478260869565216 0.41521739130434787 181 +y-26763 atorvastatin 0.6565977584511513 0.3708380722766002 0.2857596861745511 0.42093838179217913 0.1104624923318624 0.0190958171668979 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_3_computational_hit Tier_4_not_prioritized True False 0.35785953177257523 0.5183946488294314 0.4140468227424749 182 +prednisolone-acetate pd-0325901 0.666427312799478 0.40173930785293493 0.26468800494654304 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3879598662207358 0.451505016722408 0.4102006688963211 183 +etomidate pd-0325901 0.7014146247464749 0.4967667938224851 0.20464783092398975 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.46488294314381273 0.2842809364548495 0.4016722408026756 184 +geldanamycin glycocholic-acid 0.7019916990594495 0.5058375600548017 0.19615413900464773 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.47157190635451507 0.2608695652173913 0.3978260869565217 185 +ag-490 glycocholic-acid 0.5904600827821663 0.21947756487255313 0.37098251790961323 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.20066889632107024 0.7558528428093646 0.39498327759197327 186 +prochlorperazine glycocholic-acid 0.6289502565882035 0.3098850516114561 0.3190652049767474 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.26755852842809363 0.6254180602006689 0.39280936454849497 187 +arcyriaflavin-a nvp-tae684 0.7338630110431934 0.6303676216500913 0.1034953893931021 0.25139682919585277 0.135857936926186 0.176811108055214 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5551839464882943 0.07357859531772576 0.3866220735785953 188 +prednisolone-acetate wz-4002 0.7280020006980362 0.610402329433118 0.11759967126491822 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5418060200668896 0.0903010033444816 0.38377926421404684 189 +arcyriaflavin-a verteporfin 0.7200564414868871 0.5868309089019599 0.1332255325849272 0.25139682919585277 0.135857936926186 0.176811108055214 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5250836120401338 0.12040133779264214 0.3834448160535117 190 +nu-7026 bromocriptine 0.6414643342196498 0.3566813161180887 0.2847830181015611 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3110367892976589 0.5150501672240803 0.38244147157190633 191 +nu-7026 pd-0325901 0.6349472231859903 0.34212841878881645 0.29281880439717384 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2842809364548495 0.5384615384615384 0.37324414715719056 192 +geldanamycin pd-184352 0.6782768315243874 0.46964291185288437 0.20863391967150308 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.4080267558528428 0.30434782608695654 0.3717391304347826 193 +prochlorperazine pd-184352 0.6052353890531414 0.2736904034095387 0.33154498564360274 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.21739130434782608 0.6555183946488294 0.37073578595317724 194 +aminopentamide tyrphostin-1 0.6598297565258922 0.4247262345789562 0.23510352194693596 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.36454849498327757 0.38127090301003347 0.37040133779264217 195 +ag-490 pd-184352 0.5667452152471042 0.1944528978820595 0.3722923173650447 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.15384615384615385 0.7658862876254181 0.36806020066889633 196 +pre-084 tyrphostin-1 0.7042397568889316 0.5692458111304965 0.13499394575843504 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.4916387959866221 0.12709030100334448 0.3640468227424749 197 +emf-sumo1-10 bromocriptine 0.5823881208752504 0.24479462757673387 0.3375934932985165 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.19063545150501673 0.6755852842809364 0.3603678929765886 198 +geldanamycin tyrphostin-1 0.7274677076983074 0.6757186530305752 0.051749054667732164 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True False 0.5384615384615384 0.026755852842809364 0.3593645484949832 199 +bibx-1382 nvp-tae684 0.6979823764820123 0.5516689788653617 0.14631339761665063 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.46153846153846156 0.15384615384615385 0.3538461538461539 200 +emf-sumo1-10 pd-0325901 0.5758710098415908 0.2302417302474616 0.34562927959412915 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.16722408026755853 0.6956521739130435 0.3521739130434782 201 +nu-7026 wz-4002 0.6965219110845484 0.5507914403689995 0.1457304707155489 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.45819397993311034 0.1505016722408027 0.3505016722408027 202 +bibx-1382 verteporfin 0.684175806925706 0.5081322661172302 0.17604354080847584 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.4214046822742475 0.21739130434782608 0.35000000000000003 203 +loperamide glycocholic-acid 0.6659541847775616 0.4645778405376606 0.20137634423990103 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.38461538461538464 0.27759197324414714 0.3471571906354515 204 +aminopentamide ambroxol 0.5817217333685784 0.2552227861957536 0.32649894717282474 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.18394648829431437 0.6421404682274248 0.34431438127090297 205 +ticlopidine verteporfin 0.6425097536347393 0.40206972530503415 0.24044002832970512 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.3177257525083612 0.391304347826087 0.34347826086956523 206 +aminopentamide duloxetine 0.59607792165803 0.28956897951854715 0.3065089421394828 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.21070234113712374 0.5819397993311036 0.34063545150501673 207 +ticlopidine nvp-tae684 0.6563163231910458 0.44560643805316574 0.21070988513788008 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.35451505016722407 0.3076923076923077 0.33812709030100335 208 +wz-4002 glycocholic-acid 0.689013165366348 0.5420852666887057 0.14692789867764233 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.431438127090301 0.1605351170568562 0.3366220735785953 209 +aminopentamide tubocurarine 0.5640296943944006 0.21995834532445152 0.34407134906994913 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.14046822742474915 0.6923076923076923 0.3336120401337792 210 +prednisolone-acetate glycocholic-acid 0.555094016087611 0.20617386713875324 0.34892014894885776 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.13043478260869565 0.705685618729097 0.3317725752508361 211 +wz-4002 tyrphostin-1 0.7144891740052058 0.7446547698188899 -0.030165595813684054 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.5083612040133779 0.0033444816053511705 0.3316053511705686 212 +etomidate nvp-tae684 0.7038339476455888 0.6245827572420237 0.0792511904035651 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4816053511705686 0.043478260869565216 0.32826086956521744 213 +aminopentamide atorvastatin 0.5801572077538049 0.27456052179285695 0.3055966859609479 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.17725752508361203 0.5785953177257525 0.3177257525083612 214 +loperamide pd-184352 0.6422393172424995 0.42838319233574323 0.21385612490675626 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.31438127090301005 0.31438127090301005 0.31438127090301005 215 +etomidate verteporfin 0.6900273780892825 0.5810460444938923 0.1089813335953902 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.43812709030100333 0.08361204013377926 0.3140468227424749 216 +prednisolone-acetate nvp-tae684 0.6688466356985922 0.5295552712724736 0.13929136442611856 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.39464882943143814 0.14046822742474915 0.305685618729097 217 +pre-084 duloxetine 0.6404879220210695 0.43408855607008756 0.20639936595098196 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.3076923076923077 0.29431438127090304 0.3030100334448161 218 +prednisolone-acetate verteporfin 0.6550400661422856 0.48601855852434195 0.16902150761794366 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.34782608695652173 0.21070234113712374 0.29983277591973245 219 +loperamide tyrphostin-1 0.6914301934164194 0.6344589335134341 0.05697125990298535 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.44481605351170567 0.030100334448160536 0.29966555183946486 220 +prochlorperazine tyrphostin-1 0.6544262652270614 0.4797661445872295 0.17466012063983188 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True True 0.3411371237458194 0.2140468227424749 0.2966555183946488 221 +pre-084 ambroxol 0.6261317337316179 0.399742362747294 0.22638937098432388 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2608695652173913 0.35451505016722407 0.2936454849498328 222 +bibx-1382 glycocholic-acid 0.5842297568710314 0.31571589067341793 0.26851386619761347 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1939799331103679 0.47491638795986624 0.2923076923076923 223 +wz-4002 pd-184352 0.665298297831286 0.538579028641199 0.12671926919008702 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.38127090301003347 0.11371237458193979 0.2876254180602007 224 +emf-sumo1-10 wz-4002 0.637445697740149 0.43890475182764466 0.19854094591250437 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.29431438127090304 0.27424749163879597 0.28729096989966557 225 +pre-084 tubocurarine 0.6084396947574402 0.36447792187599193 0.24396177288144827 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.22073578595317725 0.39464882943143814 0.28160535117056856 226 +geldanamycin duloxetine 0.6637158728304451 0.5405613979701662 0.12315447486027886 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.3745819397993311 0.10702341137123746 0.2809364548494983 227 +ag-490 ambroxol 0.5378280682637104 0.23102519067654775 0.3068028775871627 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.10702341137123746 0.5953177257525084 0.27792642140468227 228 +prochlorperazine duloxetine 0.5906744303591992 0.34460888952682045 0.24606554083237875 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.2040133779264214 0.411371237458194 0.2765886287625418 229 +ag-490 tubocurarine 0.5201360292895327 0.19576074980524566 0.32437527948428707 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0802675585284281 0.6354515050167224 0.2745819397993311 230 +emf-sumo1-10 glycocholic-acid 0.4645377131297238 0.10148778752172533 0.3630499256079985 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.023411371237458192 0.7357859531772575 0.272742474916388 231 +prochlorperazine ambroxol 0.5763182420697477 0.31026269620402697 0.2660555458657207 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.1705685618729097 0.45819397993311034 0.27123745819397993 232 +ticlopidine glycocholic-acid 0.5425637035800647 0.23930602308015328 0.3032576804999114 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.11036789297658862 0.568561872909699 0.27073578595317727 233 +pre-084 atorvastatin 0.6245672081168445 0.41908009834439736 0.20548710977244716 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.25752508361204013 0.2909698996655518 0.2692307692307692 234 +ag-490 tyrphostin-1 0.6159360914210241 0.40052863905975034 0.2154074523612738 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.2408026755852843 0.3210702341137124 0.2688963210702341 235 +geldanamycin ambroxol 0.6493596845409936 0.5062152046473726 0.143144479893621 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.3311036789297659 0.14715719063545152 0.26672240802675584 236 +ag-490 duloxetine 0.552184256553162 0.2653713839993413 0.28681287255382065 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.12709030100334448 0.5250836120401338 0.2663879598662207 237 +prochlorperazine tubocurarine 0.55862620309557 0.2749982553327249 0.2836279477628451 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.13377926421404682 0.5083612040133779 0.26488294314381267 238 +ticlopidine pd-184352 0.5188488360450026 0.20311137487823586 0.3157374611667668 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.07357859531772576 0.6153846153846154 0.26321070234113714 239 +nu-7026 nvp-tae684 0.6373665460851043 0.46994438220835505 0.1674221638767493 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2909698996655518 0.2040133779264214 0.26053511705685617 240 +nu-7026 verteporfin 0.6235599765287978 0.42640766946022346 0.19715230706857434 0.22968370221289142 0.121435706104551 0.0272444321049584 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.25418060200668896 0.2709030100334448 0.2600334448160535 241 +arcyriaflavin-a glycocholic-acid 0.6201103914322124 0.42406720667707887 0.1960431847551335 0.25139682919585277 0.135857936926186 0.176811108055214 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.24749163879598662 0.25752508361204013 0.25100334448160533 242 +ag-490 atorvastatin 0.536263542648937 0.2503629262736511 0.28590061637528597 0.34080952472452597 0.2174672408561621 -0.0613149003022246 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.10033444816053512 0.5217391304347826 0.2478260869565217 243 +prochlorperazine atorvastatin 0.5747537164549742 0.3296004318011303 0.2451532846538439 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.16387959866220736 0.4013377926421405 0.24698996655518396 244 +geldanamycin atorvastatin 0.6477951589262201 0.5255529402444759 0.12224221868174423 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.32441471571906355 0.10033444816053512 0.2459866220735786 245 +arcyriaflavin-a pd-184352 0.5963955238971503 0.38787255847516144 0.2085229654219889 0.25139682919585277 0.135857936926186 0.176811108055214 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2140468227424749 0.3010033444816054 0.24448160535117058 246 +geldanamycin tubocurarine 0.6316676455668159 0.47095076377607054 0.16071688179074534 0.30605833711368696 0.1065098238842827 0.2312507074740198 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.27424749163879597 0.18729096989966554 0.24381270903010033 247 +etomidate glycocholic-acid 0.5900813280346078 0.37400809554974485 0.21607323248486293 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.19732441471571907 0.32441471571906355 0.24180602006688962 248 +emf-sumo1-10 verteporfin 0.5644837631843984 0.31452098091886865 0.24996278226552976 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.14381270903010032 0.4214046822742475 0.24096989966555182 249 +bibx-1382 pd-184352 0.5605148893359693 0.3091739156904319 0.25134097364553737 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.13712374581939799 0.4280936454849498 0.2389632107023411 250 +emf-sumo1-10 pd-184352 0.4408228455946618 0.11556263049207037 0.3252602151025914 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.016722408026755852 0.6387959866220736 0.23444816053511705 251 +emf-sumo1-10 nvp-tae684 0.578290332740705 0.35805769366700024 0.22023263907370472 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.17391304347826086 0.33444816053511706 0.23010033444816053 252 +loperamide duloxetine 0.6276783585485572 0.480896645876032 0.14678171267252527 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.26421404682274247 0.15719063545150502 0.22675585284280936 253 +wz-4002 duloxetine 0.6507373391373438 0.6094975147584807 0.04123982437886309 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.33444816053511706 0.016722408026755852 0.22324414715719063 254 +arcyriaflavin-a tyrphostin-1 0.6455864000710703 0.5939482996528522 0.051638100418218036 0.25139682919585277 0.135857936926186 0.176811108055214 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.3210702341137124 0.023411371237458192 0.21688963210702342 255 +loperamide ambroxol 0.6133221702591057 0.4649554851302315 0.14836668512887424 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.23411371237458195 0.16722408026755853 0.21070234113712374 256 +nu-7026 glycocholic-acid 0.5236139264741232 0.26364396723534256 0.25996995923878063 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.08361204013377926 0.44481605351170567 0.2100334448160535 257 +loperamide tubocurarine 0.595630131284928 0.42969104425892946 0.16593908702599858 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.20735785953177258 0.20066889632107024 0.20501672240802676 258 +nu-7026 pd-184352 0.49989905893906117 0.2274493190334252 0.272449739905636 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.05351170568561873 0.48494983277591974 0.20451505016722407 259 +wz-4002 ambroxol 0.6363811508478922 0.5751513214356871 0.061229829412205006 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.28762541806020064 0.03678929765886288 0.19983277591973245 260 +prednisolone-acetate pd-184352 0.531379148552549 0.2870602080975437 0.2443189404550053 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0903010033444816 0.3979933110367893 0.1979933110367893 261 +loperamide atorvastatin 0.6117576446443322 0.4842932207273348 0.12746442391699742 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.23076923076923078 0.11705685618729098 0.19096989966555186 262 +wz-4002 atorvastatin 0.6348166252331188 0.5944890570327905 0.040327568200328234 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2809364548494983 0.013377926421404682 0.18729096989966554 263 +ticlopidine tubocurarine 0.4722396500874311 0.20441922680142205 0.267820423286009 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.033444816053511704 0.47157190635451507 0.18678929765886287 264 +ticlopidine ambroxol 0.4899316890616088 0.23968366767272414 0.25024802138888463 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.046822742474916385 0.42474916387959866 0.17909698996655515 265 +etomidate pd-184352 0.5663664604995458 0.382087694067094 0.18427876643245178 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1505016722408027 0.23076923076923078 0.17859531772575252 266 +emf-sumo1-10 tubocurarine 0.3942136596370902 0.11687048241525654 0.27734317722183366 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0033444816053511705 0.49498327759197325 0.17541806020066888 267 +wz-4002 tubocurarine 0.6186891118737144 0.539886880564385 0.0788022313093294 0.24279621433067533 0.1696766402040209 0.3318178856538402 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.24414715719063546 0.04013377926421405 0.17274247491638794 268 +ticlopidine duloxetine 0.5042878773510603 0.2740298609955177 0.2302580163555426 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.06354515050167224 0.3745819397993311 0.17240802675585284 269 +bibx-1382 tyrphostin-1 0.6097057655098891 0.5152496568681226 0.09445610864176646 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.22408026755852842 0.06020066889632107 0.16672240802675584 270 +ticlopidine tyrphostin-1 0.5680397122189225 0.40918711605592667 0.1588525961629958 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.1605351170568562 0.17725752508361203 0.16638795986622074 271 +emf-sumo1-10 ambroxol 0.4119056986112679 0.15213492328655864 0.25977077532470927 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.010033444816053512 0.4414715719063545 0.16103678929765883 272 +ticlopidine atorvastatin 0.4883671634468354 0.2590214032698275 0.22934576017700792 0.27117536779093954 0.1225165724754333 -0.017839344839255 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.043478260869565216 0.3712374581939799 0.15819397993311035 273 +arcyriaflavin-a duloxetine 0.5818345652032081 0.45879104459244324 0.12304352061076484 0.25139682919585277 0.135857936926186 0.176811108055214 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.18729096989966554 0.10367892976588629 0.15802675585284282 274 +etomidate tyrphostin-1 0.6155573366734656 0.5881634352447848 0.02739390142868081 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.23745819397993312 0.010033444816053512 0.15785953177257525 275 +arcyriaflavin-a ambroxol 0.5674783769137565 0.4244448512696497 0.14303352564410676 0.25139682919585277 0.135857936926186 0.176811108055214 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.15719063545150502 0.14381270903010032 0.15250836120401337 276 +emf-sumo1-10 duloxetine 0.4262618869007195 0.18648111660935218 0.2397807702913673 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.013377926421404682 0.3879598662207358 0.14448160535117058 277 +bibx-1382 duloxetine 0.545953930642027 0.38009240180771375 0.16586152883431327 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.11371237458193979 0.19732441471571907 0.14297658862876256 278 +bibx-1382 ambroxol 0.5315977423525755 0.3457462084849201 0.1858515338676554 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.09364548494983277 0.23411371237458195 0.14280936454849497 279 +arcyriaflavin-a tubocurarine 0.5497863379395789 0.3891804103983476 0.16060592754123126 0.25139682919585277 0.135857936926186 0.176811108055214 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.12040133779264214 0.18394648829431437 0.14264214046822743 280 +bibx-1382 tubocurarine 0.5139057033783977 0.31048176761361806 0.20342393576477963 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.06688963210702341 0.2809364548494983 0.14180602006688964 281 +emf-sumo1-10 atorvastatin 0.41034117299649453 0.17147265888366198 0.23886851411283255 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.006688963210702341 0.38461538461538464 0.13896321070234113 282 +prednisolone-acetate tyrphostin-1 0.5805700247264688 0.49313594927523446 0.08743407545123433 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.1806020066889632 0.056856187290969896 0.13729096989966555 283 +nu-7026 tubocurarine 0.45328987298148965 0.22875717095661136 0.2245327020248783 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.020066889632107024 0.34448160535117056 0.13361204013377925 284 +arcyriaflavin-a atorvastatin 0.565913851298983 0.4437825868667531 0.12213126443222988 0.25139682919585277 0.135857936926186 0.176811108055214 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.14715719063545152 0.09698996655518395 0.12959866220735788 285 +nu-7026 ambroxol 0.47098191195566735 0.26402161182791345 0.2069603001277539 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.030100334448160536 0.2976588628762542 0.12374581939799331 286 +bibx-1382 atorvastatin 0.5300332167378019 0.3650839440820235 0.1649492726557784 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.08695652173913043 0.19063545150501673 0.12324414715719065 287 +prednisolone-acetate tubocurarine 0.4847699625949774 0.28836806002072984 0.19640190257424756 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.03678929765886288 0.26421404682274247 0.11638795986622073 288 +prednisolone-acetate ambroxol 0.5024620015691551 0.323632500892032 0.1788295006771231 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.06020066889632107 0.22073578595317725 0.11638795986622072 289 +nu-7026 duloxetine 0.4853381002451189 0.298367805150707 0.18697029509441193 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.04013377926421405 0.24414715719063546 0.11153846153846153 290 +nu-7026 tyrphostin-1 0.5490899351129811 0.433525060211116 0.11556487490186512 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.11705685618729098 0.08695652173913043 0.10652173913043478 291 +prednisolone-acetate duloxetine 0.5168181898586066 0.35797869421482553 0.15883949564378108 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.07023411371237458 0.17391304347826086 0.10652173913043478 291 +emf-sumo1-10 tyrphostin-1 0.4900137217685816 0.32163837166976117 0.16837535009882043 0.22550654344792875 0.1770792342722416 -0.0825536770539151 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.05016722408026756 0.20735785953177258 0.10518394648829432 293 +etomidate duloxetine 0.5518055018056035 0.4530061801843758 0.09879932162122773 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.12374581939799331 0.06688963210702341 0.10384615384615385 294 +nu-7026 atorvastatin 0.46941738634089386 0.2833593474250168 0.18605803891587708 0.22968370221289142 0.121435706104551 0.0272444321049584 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.026755852842809364 0.23745819397993312 0.10050167224080267 295 +etomidate ambroxol 0.5374493135161519 0.41865998686158223 0.11878932665456965 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.10367892976588629 0.09364548494983277 0.10016722408026756 296 +prednisolone-acetate atorvastatin 0.5008974759543816 0.34297023648913527 0.15792723946524634 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.056856187290969896 0.1705685618729097 0.09665551839464882 297 +etomidate tubocurarine 0.5197572745419742 0.38339554599028003 0.13636172855169415 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.07692307692307693 0.13043478260869565 0.09565217391304348 298 +etomidate atorvastatin 0.5358847879013784 0.43799772245868557 0.09788706544269282 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.09698996655518395 0.06354515050167224 0.08528428093645486 299 diff --git a/data/mechanism_summary/domain_wall_boundary_effect_summary.tsv b/data/mechanism_summary/domain_wall_boundary_effect_summary.tsv new file mode 100644 index 0000000..62185f5 --- /dev/null +++ b/data/mechanism_summary/domain_wall_boundary_effect_summary.tsv @@ -0,0 +1,8 @@ +module n_biopsies mean_shift median_shift bootstrap_ci_low bootstrap_ci_high wilcoxon_statistic p_value fdr +Endothelial resolver 33 0.3638541949910541 0.36837810773494784 0.3033498712692662 0.42577882640584763 2.0 6.984919309616089e-10 1.6298145055770874e-09 +Macrophage resolver 33 0.2541995063331348 0.24264737006077125 0.19994054318606044 0.30671972607132375 10.0 1.0011717677116394e-08 1.4016404747962952e-08 +Protease activation 33 0.13374393322935604 0.1294291845076384 0.08467243286075163 0.18440296641172846 41.0 2.304092049598694e-06 2.630287781357765e-06 +Antiproteolytic brake 33 0.38298122934015044 0.34651617194685636 0.30902602993386286 0.45738940676531914 0.0 2.3283064365386963e-10 8.149072527885437e-10 +HSC retention 33 0.4082297145373421 0.36631523952731426 0.3224160989089668 0.49504407959756025 0.0 2.3283064365386963e-10 8.149072527885437e-10 +TGF-beta integrator 33 0.13882677711477873 0.11701559891038267 0.09150501977256048 0.1850203248857316 42.0 2.630287781357765e-06 2.630287781357765e-06 +Structural ECM 33 0.18598674371980287 0.15283400514493511 0.13771687150472187 0.23673067646242452 3.0 1.1641532182693481e-09 2.0372681319713593e-09 diff --git a/data/mechanism_summary/ezetimibe_verteporfin_weight_sensitivity.tsv b/data/mechanism_summary/ezetimibe_verteporfin_weight_sensitivity.tsv new file mode 100644 index 0000000..aeb691b --- /dev/null +++ b/data/mechanism_summary/ezetimibe_verteporfin_weight_sensitivity.tsv @@ -0,0 +1,28 @@ +early_retention_weight resolver_weight penalty_weight forward_score order_advantage basin_switch_index rank n_pairs +0.25 0.35 1.0 0.7246761919671876 0.4179434199507038 0.844314381270903 36 299 +0.25 0.35 1.5 0.7246761919671876 0.4179434199507038 0.84314381270903 37 299 +0.25 0.35 2.0 0.7246761919671876 0.4179434199507038 0.8419732441471572 37 299 +0.25 0.5 1.0 0.9043628719842267 0.47952845282409157 0.8745819397993311 30 299 +0.25 0.5 1.5 0.9043628719842267 0.47952845282409157 0.8745819397993311 29 299 +0.25 0.5 2.0 0.9043628719842267 0.47952845282409157 0.8745819397993311 28 299 +0.25 0.65 1.0 1.084049552001266 0.5411134856974796 0.8929765886287626 25 299 +0.25 0.65 1.5 1.084049552001266 0.5411134856974796 0.8929765886287626 25 299 +0.25 0.65 2.0 1.084049552001266 0.5411134856974796 0.8929765886287626 25 299 +0.5 0.35 1.0 0.7126256437092605 0.3265284166464375 0.8093645484949834 37 299 +0.5 0.35 1.5 0.7126256437092605 0.3265284166464375 0.8081939799331104 37 299 +0.5 0.35 2.0 0.7126256437092605 0.3265284166464375 0.8058528428093645 38 299 +0.5 0.5 1.0 0.8923123237262998 0.3881134495198255 0.8724080267558529 24 299 +0.5 0.5 1.5 0.8923123237262998 0.3881134495198255 0.8724080267558529 24 299 +0.5 0.5 2.0 0.8923123237262998 0.3881134495198255 0.8712374581939799 24 299 +0.5 0.65 1.0 1.071999003743339 0.4496984823932133 0.8874581939799331 23 299 +0.5 0.65 1.5 1.071999003743339 0.4496984823932133 0.8862876254180603 23 299 +0.5 0.65 2.0 1.071999003743339 0.4496984823932133 0.8851170568561874 23 299 +0.75 0.35 1.0 0.7005750954513333 0.23511341334217117 0.7570234113712374 46 299 +0.75 0.35 1.5 0.7005750954513333 0.23511341334217117 0.7546822742474917 46 299 +0.75 0.35 2.0 0.7005750954513333 0.23511341334217117 0.7523411371237458 46 299 +0.75 0.5 1.0 0.8802617754683726 0.2966984462155591 0.8397993311036789 27 299 +0.75 0.5 1.5 0.8802617754683726 0.2966984462155591 0.8362876254180602 28 299 +0.75 0.5 2.0 0.8802617754683726 0.2966984462155591 0.8351170568561873 28 299 +0.75 0.65 1.0 1.0599484554854117 0.35828347908894687 0.8854515050167224 20 299 +0.75 0.65 1.5 1.0599484554854117 0.35828347908894687 0.8842809364548496 20 299 +0.75 0.65 2.0 1.0599484554854117 0.35828347908894687 0.8819397993311038 20 299 diff --git a/data/mechanism_summary/mechanism_edge_evidence.tsv b/data/mechanism_summary/mechanism_edge_evidence.tsv new file mode 100644 index 0000000..0696f4f --- /dev/null +++ b/data/mechanism_summary/mechanism_edge_evidence.tsv @@ -0,0 +1,25 @@ +edge_id source target relation evidence_class evidence_scope project_dataset project_result_file literature_reference doi direct_test_required +E01 WNT9B+ endothelium HSC deactivation activates project-supported association Resolver-associated endothelial state linked to HSC deactivation; direct ligand perturbation remains pending GSE295293; GSE305331 data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE305331_cross_etiology_phase_trajectories.tsv Li et al., Cell Reports 2026 10.1016/j.celrep.2025.116915 true +E02 TREM2+ macrophage MMP2 / 9 / 14 activates literature-established Restorative macrophages support matrix-degrading activity during regression GSE261829; GSE295293 data/figure_reconstruction/LAM_priority_gene_fates.tsv Ganguly et al., PNAS 2024; Fallowfield et al., Journal of Immunology 2007 10.1073/pnas.2405746121;10.4049/jimmunol.178.8.5288 false +E03 TREM2+ macrophage PLAU / PLAT activates project-supported association Macrophage resolver activity is spatially aligned with protease-activation potential UQ MASLD Visium data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_boundary_effect_summary.tsv Ganguly et al., PNAS 2024 10.1073/pnas.2405746121 true +E04 PLAU / PLAT Plasmin activates literature-established Plasminogen activators generate plasmin curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Venkatraman et al., Biophysical Journal 2012 10.1016/j.bpj.2012.06.050 false +E05 Plasmin THBS-dependent TGF-beta activation inhibits literature-established Plasmin produces a switch-like reduction in thrombospondin-dependent TGF-beta activation curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Venkatraman et al., Biophysical Journal 2012 10.1016/j.bpj.2012.06.050 false +E06 THBS-dependent TGF-beta activation Active TGF-beta activates literature-established Thrombospondin-dependent activation releases active TGF-beta curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Venkatraman et al., Biophysical Journal 2012 10.1016/j.bpj.2012.06.050 false +E07 Active TGF-beta HSC retention activates literature-established Canonical profibrotic signaling maintains activated matrix-producing HSC states curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Kisseleva and Brenner, Nature Reviews Gastroenterology and Hepatology 2021 10.1038/s41575-020-00372-7 false +E08 HSC retention SPON1-rich matrix activates project-supported association SPON1 is retained in disease-associated human HSCs and residual mouse HSC programs GSE244832; GSE295293 data/figure_reconstruction/integrated_retention_candidates.tsv Kim et al., Journal of Hepatology 2025 10.1016/j.jhep.2024.10.044 true +E09 SPON1-rich matrix Integrin alpha-v activates testable candidate edge The proposed SPON1-integrin arm is a direct binding and signaling hypothesis GSE244832; UQ MASLD Visium data/figure_reconstruction/integrated_retention_candidates.tsv Kim et al., Journal of Hepatology 2025 10.1016/j.jhep.2024.10.044 true +E10 Integrin alpha-v Active TGF-beta activates literature-established Alpha-v integrins activate a core profibrotic TGF-beta pathway curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Henderson et al., Nature Medicine 2013 10.1038/nm.3282 false +E11 HSC retention SERPINE1 / PAI-1 activates project-supported association SERPINE1 belongs to the frozen HSC-retention module and the antiproteolytic brake UQ MASLD Visium; GSE244832 data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_patient_summary.tsv Wang et al., FEBS Letters 2007 10.1016/j.febslet.2007.05.049 true +E12 HSC retention TIMP1 / TIMP2 activates project-supported association TIMP activity rises within retention-dominant scar fields UQ MASLD Visium data/UQ_spatial_derived/S14_spatial_domain_wall/domain_wall_boundary_effect_summary.tsv Yoshiji et al., Hepatology 2002; Parsons et al., Hepatology 2004 10.1053/jhep.2002.35625;10.1002/hep.20425 true +E13 SERPINE1 / PAI-1 PLAU / PLAT inhibits literature-established PAI-1 inhibits plasminogen activators and limits proteolytic fibrinolysis curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Wang et al., FEBS Letters 2007 10.1016/j.febslet.2007.05.049 false +E14 TIMP1 / TIMP2 MMP2 / 9 / 14 inhibits literature-established TIMP activity restrains metalloproteinase-mediated matrix degradation and resolution curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Yoshiji et al., Hepatology 2002; Parsons et al., Hepatology 2004 10.1053/jhep.2002.35625;10.1002/hep.20425 false +E15 MMP2 / 9 / 14 ECM cleavage activates literature-established Metalloproteinase activity supports scar degradation GSE261829; UQ MASLD Visium data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_gene_detection.tsv Fallowfield et al., Journal of Immunology 2007 10.4049/jimmunol.178.8.5288 false +E16 ECM cleavage Retained matrix inhibits literature-established Matrix cleavage reduces persistent scar material curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Iredale et al., Journal of Clinical Investigation 1998 10.1172/JCI1018 false +E17 HSC retention LOX / crosslinking activates project-supported association Retained HSC and structural-ECM programs support a crosslinking arm UQ MASLD Visium data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_spot_scores.parquet Liu et al., FASEB Journal 2016; Ikenaga et al., Gut 2017 10.1096/fj.14-268425;10.1136/gutjnl-2016-312473 true +E18 LOX / crosslinking Stiff ECM activates literature-established LOX-family collagen crosslinking stabilizes scar and limits reversal curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Liu et al., FASEB Journal 2016; Ikenaga et al., Gut 2017 10.1096/fj.14-268425;10.1136/gutjnl-2016-312473 false +E19 Stiff ECM YAP / TEAD activates literature-established Mechanical matrix signaling activates YAP in hepatic stellate cells curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Mannaerts et al., Journal of Hepatology 2015 10.1016/j.jhep.2014.09.011 false +E20 YAP / TEAD HSC retention activates literature-established YAP activity supports the activated hepatic stellate-cell state GSE136103 HSC perturbation data/perturbation_derived/celloracle/celloracle_v16_ap1_runx2_ko.tsv Mannaerts et al., Journal of Hepatology 2015 10.1016/j.jhep.2014.09.011 false +E21 Stiff ECM AP-1 / RUNX activates project-supported association Motif and perturbation analyses place AP-1 and RUNX in a context-dependent retention architecture GSE136103; scGPT; CellOracle; LINCS data/perturbation_derived/celloracle/celloracle_v16_ap1_runx2_ko.tsv Kim et al., Journal of Hepatology 2025 10.1016/j.jhep.2024.10.044 true +E22 AP-1 / RUNX HSC retention activates testable candidate edge Cross-platform direction is subunit- and context-dependent; direct phase-resolved perturbation is required GSE136103; scGPT; CellOracle; LINCS data/perturbation_derived/LINCS_AP1/AP1_HEPG2_arbitration.tsv Kim et al., Journal of Hepatology 2025 10.1016/j.jhep.2024.10.044 true +E23 Retained matrix Stiff ECM activates literature-established Accumulated and crosslinked matrix increases mechanical restraint curated mechanism data/mechanism_summary/mechanism_edge_evidence.tsv Liu et al., FASEB Journal 2016 10.1096/fj.14-268425 false +E24 HSC retention Retained matrix activates project-supported association Retention-dominant HSC programs increasingly occupy the scar field across fibrosis stages UQ MASLD Visium data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_stage_trends.tsv Vu et al., JHEP Reports 2026 10.1016/j.jhepr.2025.101657 true diff --git a/data/mechanism_summary/mouse_phase_trajectory_summary.json b/data/mechanism_summary/mouse_phase_trajectory_summary.json new file mode 100644 index 0000000..7e98924 --- /dev/null +++ b/data/mechanism_summary/mouse_phase_trajectory_summary.json @@ -0,0 +1,103 @@ +{ + "n_replicated_mice": 9, + "geometry": { + "progression_vector": [ + 1.8517825485074735, + 1.4121560803037632 + ], + "withdrawal_vector": [ + -0.4113883868762583, + -0.6569694957746913 + ], + "return_cosine": 0.9359570143983825, + "return_angle_degrees": 20.616688658580056, + "residual_distance_ratio": 0.6983693102084559, + "control_centroid": [ + -1.0973922367128963, + -0.7224475549442783 + ], + "fibrosis_centroid": [ + 0.7543903117945772, + 0.6897085253594848 + ], + "regression_centroid": [ + 0.3430019249183189, + 0.032739029584793446 + ] + }, + "tests": [ + { + "outcome": "resolver_axis", + "contrast": "progression", + "effect": 1.8517825485074735, + "exact_two_sided_p": 0.004164187983343248, + "exact_directional_p": 0.002379535990481856, + "n_assignments": 1680 + }, + { + "outcome": "resolver_axis", + "contrast": "withdrawal", + "effect": -0.4113883868762583, + "exact_two_sided_p": 0.5823914336704342, + "exact_directional_p": 0.2914931588340274, + "n_assignments": 1680 + }, + { + "outcome": "resolver_axis", + "contrast": "residual", + "effect": 1.4403941616312153, + "exact_two_sided_p": 0.042236763831052945, + "exact_directional_p": 0.021415823914336704, + "n_assignments": 1680 + }, + { + "outcome": "lock_axis", + "contrast": "progression", + "effect": 1.4121560803037632, + "exact_two_sided_p": 0.006543723973825104, + "exact_directional_p": 0.003569303985722784, + "n_assignments": 1680 + }, + { + "outcome": "lock_axis", + "contrast": "withdrawal", + "effect": -0.6569694957746913, + "exact_two_sided_p": 0.32540154669839383, + "exact_directional_p": 0.16299821534800712, + "n_assignments": 1680 + }, + { + "outcome": "lock_axis", + "contrast": "residual", + "effect": 0.7551865845290717, + "exact_two_sided_p": 0.2552052349791791, + "exact_directional_p": 0.12790005948839978, + "n_assignments": 1680 + }, + { + "outcome": "control_imbalance", + "contrast": "progression", + "effect": -0.3108628568559357, + "exact_two_sided_p": 0.3075550267697799, + "exact_directional_p": 0.15407495538370017, + "n_assignments": 1680 + }, + { + "outcome": "control_imbalance", + "contrast": "withdrawal", + "effect": -0.17365206743339404, + "exact_two_sided_p": 0.5728732897085068, + "exact_directional_p": 0.2867340868530637, + "n_assignments": 1680 + }, + { + "outcome": "control_imbalance", + "contrast": "residual", + "effect": -0.4845149242893297, + "exact_two_sided_p": 0.06841165972635337, + "exact_directional_p": 0.034503271861986914, + "n_assignments": 1680 + } + ], + "claim": "Withdrawal follows a non-reciprocal trajectory with residual displacement in resolver-lock space." +} diff --git a/data/mechanism_summary/phase_axis_definition_sensitivity.tsv b/data/mechanism_summary/phase_axis_definition_sensitivity.tsv new file mode 100644 index 0000000..b88dfe0 --- /dev/null +++ b/data/mechanism_summary/phase_axis_definition_sensitivity.tsv @@ -0,0 +1,4 @@ +axis_definition resolver_column lock_column bic_gain_one_to_two n_patients stage_beta hc3_se hc3_p within_array_permutation_p spearman_rho permutation_fdr +pca_primary resolver_axis lock_axis 141.01218590066708 32 0.08210263761216538 0.02607662330614558 0.001641023444792728 0.0006 0.5876135741248465 0.0018 +mechanistic_equal resolver_mechanistic_equal lock_mechanistic_equal 219.82349320980632 32 0.07714697772692802 0.02725331729606637 0.004644086889319471 0.0014 0.6059066441697332 0.0021 +compact_equal resolver_compact_equal lock_compact_equal 151.6566400194663 32 0.06478084191423046 0.024015755955938776 0.0069876787848987265 0.0044 0.5262392257995167 0.0044 diff --git a/data/mechanism_summary/phase_basin_summary.json b/data/mechanism_summary/phase_basin_summary.json new file mode 100644 index 0000000..f93d1f2 --- /dev/null +++ b/data/mechanism_summary/phase_basin_summary.json @@ -0,0 +1,76 @@ +{ + "n_spots": 13585, + "n_biopsies": 33, + "n_patients": 32, + "n_spatial_blocks": 589, + "best_gmm_components": 2, + "bic_gain_one_to_two": 141.01218590066708, + "patient_bootstrap_multibasin_fraction": 1.0, + "leave_one_patient_out": { + "median_posterior_r": 0.9995959902588478, + "median_posterior_mae": 0.006976557223550208, + "median_basin_agreement": 1.0, + "minimum_basin_agreement": 0.9722222222222222 + }, + "locked_fraction_stage_trend": { + "basin_state": "locked", + "n_patients": 32, + "stage_beta": 0.038613280898779544, + "hc3_se": 0.008585501285919653, + "hc3_p": 6.8757580323628966e-06, + "within_array_permutation_p": 0.0001, + "spearman_rho": 0.6246114522559348, + "permutation_fdr": 0.00030000000000000003 + }, + "axis_definition_sensitivity": [ + { + "axis_definition": "pca_primary", + "resolver_column": "resolver_axis", + "lock_column": "lock_axis", + "bic_gain_one_to_two": 141.01218590066708, + "n_patients": 32, + "stage_beta": 0.08210263761216538, + "hc3_se": 0.02607662330614558, + "hc3_p": 0.001641023444792728, + "within_array_permutation_p": 0.0006, + "spearman_rho": 0.5876135741248465, + "permutation_fdr": 0.0018 + }, + { + "axis_definition": "mechanistic_equal", + "resolver_column": "resolver_mechanistic_equal", + "lock_column": "lock_mechanistic_equal", + "bic_gain_one_to_two": 219.82349320980632, + "n_patients": 32, + "stage_beta": 0.07714697772692802, + "hc3_se": 0.02725331729606637, + "hc3_p": 0.004644086889319471, + "within_array_permutation_p": 0.0014, + "spearman_rho": 0.6059066441697332, + "permutation_fdr": 0.0021 + }, + { + "axis_definition": "compact_equal", + "resolver_column": "resolver_compact_equal", + "lock_column": "lock_compact_equal", + "bic_gain_one_to_two": 151.6566400194663, + "n_patients": 32, + "stage_beta": 0.06478084191423046, + "hc3_se": 0.024015755955938776, + "hc3_p": 0.0069876787848987265, + "within_array_permutation_p": 0.0044, + "spearman_rho": 0.5262392257995167, + "permutation_fdr": 0.0044 + } + ], + "matched_ECM_stage_memory": { + "test": "matched_ECM_resolver_stage_memory", + "n_blocks": 589, + "n_patients": 32, + "stage_beta_logit_locked": -0.025300022004231596, + "cluster_se": 0.06507265124256584, + "cluster_p": 0.6974266565339757, + "within_array_patient_permutation_p": 0.6881 + }, + "interpretation": "A robust two-basin resolver-lock landscape and a stage-invariant separatrix support thresholded basin switching as a therapeutic control principle." +} diff --git a/data/mechanism_summary/phase_state_fraction_trends.tsv b/data/mechanism_summary/phase_state_fraction_trends.tsv new file mode 100644 index 0000000..c23398e --- /dev/null +++ b/data/mechanism_summary/phase_state_fraction_trends.tsv @@ -0,0 +1,4 @@ +basin_state n_patients stage_beta hc3_se hc3_p within_array_permutation_p spearman_rho permutation_fdr +resolved 32 -0.02926402829515349 0.007735061534817672 0.0001547651033401755 0.0003 -0.5768489751633514 0.00045 +transition 32 -0.00934925260362628 0.002993995695403677 0.0017922018420368422 0.0009 -0.4841774126589103 0.0009000000000000001 +locked 32 0.038613280898779544 0.008585501285919653 6.8757580323628966e-06 0.0001 0.6246114522559348 0.00030000000000000003 diff --git a/data/mechanism_summary/sequential_basin_switch_summary.json b/data/mechanism_summary/sequential_basin_switch_summary.json new file mode 100644 index 0000000..ac1a79c --- /dev/null +++ b/data/mechanism_summary/sequential_basin_switch_summary.json @@ -0,0 +1,35 @@ +{ + "n_eligible_compounds": 394, + "n_early_primers": 20, + "n_late_suppressors": 15, + "n_ordered_pairs": 299, + "lead_pair": "ezetimibe -> verteporfin", + "lead_pair_metrics": { + "early_compound": "ezetimibe", + "late_compound": "verteporfin", + "forward_score": 0.8923123237262998, + "reverse_score": 0.5041988742064742, + "order_advantage": 0.3881134495198255, + "early_mean_resolver": 0.5361593619787267, + "early_resolver_floor": 0.2945428660937718, + "early_retention": -0.0482021930317084, + "late_retention": 0.3174578201853567, + "late_q25_retention": 0.1837441553879115, + "late_resolver_floor": 0.0395371671766042, + "early_tier": "Tier_4_not_prioritized", + "late_tier": "Tier_1_mechanistic_probe", + "both_named": true, + "both_hard_gate": false, + "forward_percentile": 0.9063545150501672, + "order_percentile": 0.8093645484949833, + "basin_switch_index": 0.8724080267558529, + "basin_switch_rank": 24 + }, + "weight_sensitivity": { + "median_rank": 28.0, + "best_rank": 20, + "worst_rank": 46, + "n_schemes": 27 + }, + "claim": "A prime-then-switch hypothesis with a strong computed direction advantage; designed for direct equal-exposure order testing." +} diff --git a/data/mechanism_summary/spatial_domain_stage_trends.tsv b/data/mechanism_summary/spatial_domain_stage_trends.tsv new file mode 100644 index 0000000..94e5d07 --- /dev/null +++ b/data/mechanism_summary/spatial_domain_stage_trends.tsv @@ -0,0 +1,5 @@ +metric stage_beta_array_adjusted hc3_p_value within_array_permutation_p spearman_rho spearman_p_value permutation_fdr +locked_fraction 0.03243871913389098 3.553461718547866e-05 9.999000099990002e-05 0.625235989768342 0.00010012679857715102 0.00019998000199980003 +largest_locked_domain_fraction 0.09603914800529065 0.00013954776364168145 0.00029997000299970003 0.6661168044839644 2.323376270178767e-05 0.00039996000399960006 +locked_domain_coherence 0.0997187593043891 0.003520790685010989 0.0008999100089991 0.6427563389321802 5.494690318457967e-05 0.0008999100089991 +interface_edge_fraction -0.028733200324141162 0.0003569398378699087 9.999000099990002e-05 -0.6173346558317091 0.00012971777629381808 0.00019998000199980003 diff --git a/data/mechanism_summary/spatial_domain_threshold_sensitivity.tsv b/data/mechanism_summary/spatial_domain_threshold_sensitivity.tsv new file mode 100644 index 0000000..9ac883e --- /dev/null +++ b/data/mechanism_summary/spatial_domain_threshold_sensitivity.tsv @@ -0,0 +1,9 @@ +p_locked_threshold metric stage_beta_array_adjusted hc3_p_value hc3_fdr +0.4 largest_locked_domain_fraction 0.07366470518952815 0.002130593642553087 0.002130593642553087 +0.4 interface_edge_fraction -0.03248224585627828 0.00017338014850067538 0.0004623470626684677 +0.5 largest_locked_domain_fraction 0.09603914800529065 0.00013954776364168145 0.0004623470626684677 +0.5 interface_edge_fraction -0.028733200324141162 0.0003569398378699087 0.0004795001264972294 +0.6 largest_locked_domain_fraction 0.102248117132203 0.00035962509487292205 0.0004795001264972294 +0.6 interface_edge_fraction -0.027894116150220576 0.0006117912821531163 0.0006991900367464187 +0.67 largest_locked_domain_fraction 0.09348749097041878 0.000334006733761443 0.0004795001264972294 +0.67 interface_edge_fraction -0.028563074798712104 0.0001308180240038152 0.0004623470626684677 diff --git a/data/mechanism_summary/spatial_domain_wall_summary.json b/data/mechanism_summary/spatial_domain_wall_summary.json new file mode 100644 index 0000000..f592adf --- /dev/null +++ b/data/mechanism_summary/spatial_domain_wall_summary.json @@ -0,0 +1,27 @@ +{ + "n_spots": 13585, + "n_biopsies": 33, + "n_patients": 32, + "boundary_definition": "p_locked >= 0.5; signed shortest-path distance to nearest opposite-basin spot", + "largest_domain_stage_beta": 0.09603914800529065, + "largest_domain_permutation_fdr": 0.00039996000399960006, + "interface_stage_beta": -0.028733200324141162, + "interface_permutation_fdr": 0.00019998000199980003, + "threshold_sensitivity": { + "thresholds": [ + 0.4, + 0.5, + 0.6, + 0.67 + ], + "largest_domain_beta_range": [ + 0.07366470518952815, + 0.102248117132203 + ], + "interface_beta_range": [ + -0.03248224585627828, + -0.027894116150220576 + ] + }, + "interpretation": "Fibrosis progression consolidates initially fragmented locked islands into a dominant spatial domain while compressing the resolved-locked interface; across that interface the resolver advantage changes sign as HSC retention and antiproteolytic control overtake resolver activity." +} diff --git a/data/mouse_pseudobulk_derived/pseudobulk_counts.tsv.gz b/data/mouse_pseudobulk_derived/pseudobulk_counts.tsv.gz new file mode 100644 index 0000000..96863d6 Binary files /dev/null and b/data/mouse_pseudobulk_derived/pseudobulk_counts.tsv.gz differ diff --git a/data/mouse_pseudobulk_derived/pseudobulk_metadata.tsv b/data/mouse_pseudobulk_derived/pseudobulk_metadata.tsv new file mode 100644 index 0000000..51bccdf --- /dev/null +++ b/data/mouse_pseudobulk_derived/pseudobulk_metadata.tsv @@ -0,0 +1,64 @@ +pseudobulk sample cell_type condition n_cells +GSM8944960__B_cell GSM8944960 B_cell control 99 +GSM8944960__Cholangiocyte GSM8944960 Cholangiocyte control 135 +GSM8944960__Endothelial GSM8944960 Endothelial control 1398 +GSM8944960__HSC_Mesenchymal GSM8944960 HSC_Mesenchymal control 574 +GSM8944960__Hepatocyte GSM8944960 Hepatocyte control 3385 +GSM8944960__Myeloid GSM8944960 Myeloid control 654 +GSM8944960__T_NK GSM8944960 T_NK control 78 +GSM8944961__B_cell GSM8944961 B_cell control 205 +GSM8944961__Cholangiocyte GSM8944961 Cholangiocyte control 90 +GSM8944961__Endothelial GSM8944961 Endothelial control 1668 +GSM8944961__HSC_Mesenchymal GSM8944961 HSC_Mesenchymal control 590 +GSM8944961__Hepatocyte GSM8944961 Hepatocyte control 2624 +GSM8944961__Myeloid GSM8944961 Myeloid control 642 +GSM8944961__T_NK GSM8944961 T_NK control 185 +GSM8944962__B_cell GSM8944962 B_cell control 77 +GSM8944962__Cholangiocyte GSM8944962 Cholangiocyte control 96 +GSM8944962__Endothelial GSM8944962 Endothelial control 1469 +GSM8944962__HSC_Mesenchymal GSM8944962 HSC_Mesenchymal control 704 +GSM8944962__Hepatocyte GSM8944962 Hepatocyte control 3421 +GSM8944962__Myeloid GSM8944962 Myeloid control 815 +GSM8944962__T_NK GSM8944962 T_NK control 135 +GSM8944963__B_cell GSM8944963 B_cell fibrosis 304 +GSM8944963__Cholangiocyte GSM8944963 Cholangiocyte fibrosis 689 +GSM8944963__Endothelial GSM8944963 Endothelial fibrosis 1187 +GSM8944963__HSC_Mesenchymal GSM8944963 HSC_Mesenchymal fibrosis 756 +GSM8944963__Hepatocyte GSM8944963 Hepatocyte fibrosis 1501 +GSM8944963__Myeloid GSM8944963 Myeloid fibrosis 1850 +GSM8944963__T_NK GSM8944963 T_NK fibrosis 316 +GSM8944964__B_cell GSM8944964 B_cell fibrosis 383 +GSM8944964__Cholangiocyte GSM8944964 Cholangiocyte fibrosis 535 +GSM8944964__Endothelial GSM8944964 Endothelial fibrosis 1279 +GSM8944964__HSC_Mesenchymal GSM8944964 HSC_Mesenchymal fibrosis 642 +GSM8944964__Hepatocyte GSM8944964 Hepatocyte fibrosis 1440 +GSM8944964__Myeloid GSM8944964 Myeloid fibrosis 1525 +GSM8944964__T_NK GSM8944964 T_NK fibrosis 395 +GSM8944965__B_cell GSM8944965 B_cell fibrosis 204 +GSM8944965__Cholangiocyte GSM8944965 Cholangiocyte fibrosis 823 +GSM8944965__Endothelial GSM8944965 Endothelial fibrosis 953 +GSM8944965__HSC_Mesenchymal GSM8944965 HSC_Mesenchymal fibrosis 670 +GSM8944965__Hepatocyte GSM8944965 Hepatocyte fibrosis 1328 +GSM8944965__Myeloid GSM8944965 Myeloid fibrosis 1166 +GSM8944965__T_NK GSM8944965 T_NK fibrosis 211 +GSM8944966__B_cell GSM8944966 B_cell regression 156 +GSM8944966__Cholangiocyte GSM8944966 Cholangiocyte regression 140 +GSM8944966__Endothelial GSM8944966 Endothelial regression 796 +GSM8944966__HSC_Mesenchymal GSM8944966 HSC_Mesenchymal regression 455 +GSM8944966__Hepatocyte GSM8944966 Hepatocyte regression 915 +GSM8944966__Myeloid GSM8944966 Myeloid regression 587 +GSM8944966__T_NK GSM8944966 T_NK regression 122 +GSM8944967__B_cell GSM8944967 B_cell regression 197 +GSM8944967__Cholangiocyte GSM8944967 Cholangiocyte regression 224 +GSM8944967__Endothelial GSM8944967 Endothelial regression 1093 +GSM8944967__HSC_Mesenchymal GSM8944967 HSC_Mesenchymal regression 594 +GSM8944967__Hepatocyte GSM8944967 Hepatocyte regression 1507 +GSM8944967__Myeloid GSM8944967 Myeloid regression 706 +GSM8944967__T_NK GSM8944967 T_NK regression 124 +GSM8944968__B_cell GSM8944968 B_cell regression 229 +GSM8944968__Cholangiocyte GSM8944968 Cholangiocyte regression 205 +GSM8944968__Endothelial GSM8944968 Endothelial regression 1004 +GSM8944968__HSC_Mesenchymal GSM8944968 HSC_Mesenchymal regression 545 +GSM8944968__Hepatocyte GSM8944968 Hepatocyte regression 1015 +GSM8944968__Myeloid GSM8944968 Myeloid regression 629 +GSM8944968__T_NK GSM8944968 T_NK regression 185 diff --git a/data/mouse_pseudobulk_derived/state_module_trajectories.tsv b/data/mouse_pseudobulk_derived/state_module_trajectories.tsv new file mode 100644 index 0000000..092a224 --- /dev/null +++ b/data/mouse_pseudobulk_derived/state_module_trajectories.tsv @@ -0,0 +1,29 @@ +sample etiology timepoint week cell_type module mean median count n_genes +GSM9168817 CCl4 peak 0 HSC_Mesenchymal HSC_pathogenic_retention 0.044837118038381536 0.011377975575660587 9201 11 +GSM9168817 CCl4 peak 0 HSC_Mesenchymal HSC_SFRP_brake 0.03837441879735157 -0.041500976638891025 9201 4 +GSM9168817 CCl4 peak 0 Endothelial Endo4_WNT_resolver 0.05559672354948232 -0.025589299381109747 6851 7 +GSM9168817 CCl4 peak 0 Myeloid LAM_resolver 0.16084123982176332 0.14070929855171 4029 8 +GSM9168818 CCl4 2wk 2 HSC_Mesenchymal HSC_pathogenic_retention 0.10110538608070806 0.06573267300263633 7605 11 +GSM9168818 CCl4 2wk 2 HSC_Mesenchymal HSC_SFRP_brake 0.028651966022186906 -0.050491938437270054 7605 4 +GSM9168818 CCl4 2wk 2 Endothelial Endo4_WNT_resolver 0.0671932414639214 -0.02630817816781899 7285 7 +GSM9168818 CCl4 2wk 2 Myeloid LAM_resolver 0.14648887987478204 0.12937625436266112 2773 8 +GSM9168819 CCl4 6wk 6 HSC_Mesenchymal HSC_pathogenic_retention 0.06595994670326571 0.04852381139580959 6796 11 +GSM9168819 CCl4 6wk 6 HSC_Mesenchymal HSC_SFRP_brake 0.017317965214582627 -0.024272535976937244 6796 4 +GSM9168819 CCl4 6wk 6 Endothelial Endo4_WNT_resolver 0.04383341229247698 -0.02715253970877485 9791 7 +GSM9168819 CCl4 6wk 6 Myeloid LAM_resolver 0.08407762297200466 0.056570352446447536 4728 8 +GSM9168820 FAT_MASH peak 0 HSC_Mesenchymal HSC_pathogenic_retention 0.09665106552693069 0.060068105290598986 8169 11 +GSM9168820 FAT_MASH peak 0 HSC_Mesenchymal HSC_SFRP_brake 0.035609392979782495 -0.057177329888702194 8169 4 +GSM9168820 FAT_MASH peak 0 Endothelial Endo4_WNT_resolver 0.05459206953419097 -0.001346347882229204 9901 7 +GSM9168820 FAT_MASH peak 0 Myeloid LAM_resolver 0.23639307471561236 0.22130479550179694 7509 8 +GSM9168821 FAT_MASH 2wk 2 HSC_Mesenchymal HSC_pathogenic_retention 0.09563315604905781 0.06538628369337435 4546 11 +GSM9168821 FAT_MASH 2wk 2 HSC_Mesenchymal HSC_SFRP_brake 0.03286611502384619 -0.030385519603344575 4546 4 +GSM9168821 FAT_MASH 2wk 2 Endothelial Endo4_WNT_resolver 0.07170455478870447 -0.015536241341286634 7058 7 +GSM9168821 FAT_MASH 2wk 2 Myeloid LAM_resolver 0.17557552862367937 0.16970030405748393 2983 8 +GSM9168822 FAT_MASH 6wk 6 HSC_Mesenchymal HSC_pathogenic_retention 0.12768779891390025 0.09593824354159974 4800 11 +GSM9168822 FAT_MASH 6wk 6 HSC_Mesenchymal HSC_SFRP_brake 0.017340680622555095 -0.026103896392037508 4800 4 +GSM9168822 FAT_MASH 6wk 6 Endothelial Endo4_WNT_resolver 0.0537378420714683 -0.017985948831800262 7729 7 +GSM9168822 FAT_MASH 6wk 6 Myeloid LAM_resolver 0.052033102951695935 0.030037300466202288 2929 8 +GSM9168823 Untreated baseline -1 HSC_Mesenchymal HSC_pathogenic_retention 0.045142360658315644 0.022425505462450646 4095 11 +GSM9168823 Untreated baseline -1 HSC_Mesenchymal HSC_SFRP_brake 0.007638631415360531 -0.033884721007220564 4095 4 +GSM9168823 Untreated baseline -1 Endothelial Endo4_WNT_resolver 0.07743706943229813 0.06760546490575663 7391 7 +GSM9168823 Untreated baseline -1 Myeloid LAM_resolver 0.0941818155767286 0.08087910660043346 3162 8 diff --git a/data/perturbation_derived/LINCS_AP1/AP1_HEPG2_arbitration.tsv b/data/perturbation_derived/LINCS_AP1/AP1_HEPG2_arbitration.tsv new file mode 100644 index 0000000..b431a55 --- /dev/null +++ b/data/perturbation_derived/LINCS_AP1/AP1_HEPG2_arbitration.tsv @@ -0,0 +1,5 @@ +sig_id target cell_id pert_time n_same_context_cgs retention_suppression retention_suppression_percentile retention_suppression_empirical_p_low retention_suppression_empirical_p_high retention_suppression_empirical_p_two_sided fra_rescue fra_rescue_percentile fra_rescue_empirical_p_low fra_rescue_empirical_p_high fra_rescue_empirical_p_two_sided dual_control_score dual_control_score_percentile dual_control_score_empirical_p_low dual_control_score_empirical_p_high dual_control_score_empirical_p_two_sided n_contexts median_fra_rescue fraction_fra_positive median_dual_control fraction_dual_positive trt_oe trt_sh trt_sh.cgs cgs_hairpin_same_sign cgs_oe_opposite_sign +CGS001_HEPG2_96H:FOS:1.5 FOS HEPG2 96 3341 -0.16412481448302665 0.1418736905118228 0.14213046080191502 0.8584679832435668 0.28426092160383004 -0.127700602045617 0.13049985034420833 0.13076002393776182 0.86983842010772 0.26152004787552363 -0.3533239640916387 0.25710865010475903 0.2573309395571514 0.7432675044883303 0.5146618791143028 14 -0.11234651215940154 0.35714285714285715 -0.05537663037992184 0.5 0.16669259489053914 -0.08230032715212318 -0.127700602045617 True True +CGS001_HEPG2_96H:FOSL2:1.5 FOSL2 HEPG2 96 3341 0.11188952319530977 0.5929362466327447 0.5930580490724118 0.40754039497307004 0.8150807899461401 0.11840217179735686 0.6129901227177492 0.6131059245960503 0.38749251944943147 0.7749850388988629 -0.7126504208685623 0.09847351092487279 0.09874326750448834 0.9018551765409935 0.19748653500897667 10 0.15777342121437993 1.0 -0.6373877033280829 0.0 0.2696073049085438 0.11395874439129312 0.11840217179735686 True False +CGS001_HEPG2_96H:JUN:1.5 JUN HEPG2 96 3341 0.17493173542122045 0.7102663873091889 0.7103530819868342 0.29024536205864754 0.5804907241172951 0.06406140557453971 0.49416342412451364 0.4943147815679234 0.5062836624775583 0.9886295631358468 0.040648244410043666 0.5633043998802754 0.5634350688210652 0.4371633752244165 0.874326750448833 15 -0.02271471509148463 0.4 -0.04693501603434838 0.4 0.07904740132328117 0.06406140557453971 True False +CGS001_HEPG2_96H:JUNB:1.5 JUNB HEPG2 96 3341 -0.06857356263531579 0.26608799760550733 0.2663076002393776 0.7342908438061041 0.5326152004787552 0.1199102173458067 0.615983238551332 0.616098144823459 0.3845002992220227 0.7690005984440454 -0.5650979450179471 0.15294821909607903 0.15320167564332735 0.8473967684021544 0.3064033512866547 9 0.24006521424143373 0.8888888888888888 -0.5406419430223723 0.2222222222222222 0.03488645335217342 -0.02881320672377398 0.1199102173458067 False False diff --git a/data/perturbation_derived/LINCS_AP1/AP1_HEPG2_directional_concordance.tsv b/data/perturbation_derived/LINCS_AP1/AP1_HEPG2_directional_concordance.tsv new file mode 100644 index 0000000..4aa9c53 --- /dev/null +++ b/data/perturbation_derived/LINCS_AP1/AP1_HEPG2_directional_concordance.tsv @@ -0,0 +1,5 @@ +target trt_oe trt_sh trt_sh.cgs cgs_hairpin_same_sign cgs_oe_opposite_sign +FOS 0.16669259489053914 -0.08230032715212318 -0.127700602045617 True True +FOSL2 0.2696073049085438 0.11395874439129312 0.11840217179735686 True False +JUN 0.07904740132328117 0.06406140557453971 True False +JUNB 0.03488645335217342 -0.02881320672377398 0.1199102173458067 False False diff --git a/data/perturbation_derived/LINCS_AP1/AP1_consensus_shRNA_pan_context.tsv b/data/perturbation_derived/LINCS_AP1/AP1_consensus_shRNA_pan_context.tsv new file mode 100644 index 0000000..0dfee55 --- /dev/null +++ b/data/perturbation_derived/LINCS_AP1/AP1_consensus_shRNA_pan_context.tsv @@ -0,0 +1,5 @@ +target n_contexts cell_lines median_retention_suppression fraction_retention_positive median_fra_rescue fraction_fra_positive median_dual_control fraction_dual_positive +FOS 14 A375;A549;ASC;HA1E;HCC515;HEPG2;HT29;MCF7;NPC;PC3;SKL;VCAP -0.08508262912639314 0.35714285714285715 -0.11234651215940154 0.35714285714285715 -0.05537663037992184 0.5 +FOSL2 10 A375;A549;HA1E;HEPG2;HT29;MCF7;PC3;VCAP 0.06961076334118843 0.7 0.15777342121437993 1.0 -0.6373877033280829 0.0 +JUN 15 A375;A549;ASC;HA1E;HCC515;HEKTE;HEPG2;HT29;MCF7;NPC;PC3;SW480;VCAP -0.0060869018650717205 0.4666666666666667 -0.02271471509148463 0.4 -0.04693501603434838 0.4 +JUNB 9 A375;A549;HA1E;HCC515;HEPG2;HT29;MCF7;PC3;VCAP -0.024543782903088465 0.4444444444444444 0.24006521424143373 0.8888888888888888 -0.5406419430223723 0.2222222222222222 diff --git a/data/perturbation_derived/celloracle/candidate_null_adjusted_summary.tsv b/data/perturbation_derived/celloracle/candidate_null_adjusted_summary.tsv new file mode 100644 index 0000000..8ee9966 --- /dev/null +++ b/data/perturbation_derived/celloracle/candidate_null_adjusted_summary.tsv @@ -0,0 +1,4 @@ +state_slug target matched_control n_donors mean_fra_rescue_observed mean_fra_rescue_matched_control mean_fra_rescue_randomized_grn mean_null_adjusted_fra_rescue bootstrap_ci_low bootstrap_ci_high n_donors_positive_adjusted_rescue directional_rescue_supported native_method +hsc_myofibroblast RUNX2 ETV6 5 4.805539129547783e-05 0.0005593825985372311 9.661111407107707e-05 -0.00027994146500867634 -0.0003582969747435537 -0.00021647086723840516 0 False CellOracle_0.18.0_donor_mean_exact_propagation +hsc_myofibroblast JUN ID3 5 0.03410921452103818 -0.007211300114499136 0.025336880167544446 0.025046424494515523 0.023365395958837975 0.027487237563817733 5 True CellOracle_0.18.0_donor_mean_exact_propagation +hsc_myofibroblast FOS JUNB 5 0.09184354975029448 -0.017191209582944837 0.011760115562147903 0.09455909676069295 0.0888072963924941 0.10031089712889178 5 True CellOracle_0.18.0_donor_mean_exact_propagation diff --git a/data/perturbation_derived/celloracle/celloracle_v16_ap1_runx2_ko.tsv b/data/perturbation_derived/celloracle/celloracle_v16_ap1_runx2_ko.tsv new file mode 100644 index 0000000..57d7469 --- /dev/null +++ b/data/perturbation_derived/celloracle/celloracle_v16_ap1_runx2_ko.tsv @@ -0,0 +1,4 @@ +celloracle_rank_v16 state_slug target matched_control n_donors mean_fra_rescue_observed mean_fra_rescue_matched_control mean_fra_rescue_randomized_grn mean_null_adjusted_fra_rescue bootstrap_ci_low bootstrap_ci_high n_donors_positive_adjusted_rescue directional_rescue_supported native_method +1 hsc_myofibroblast FOS JUNB 5 0.0918435497502944 -0.0171912095829448 0.0117601155621479 0.0945590967606929 0.0888072963924941 0.1003108971288917 5 True CellOracle_0.18.0_donor_mean_exact_propagation +2 hsc_myofibroblast JUN ID3 5 0.0341092145210381 -0.0072113001144991 0.0253368801675444 0.0250464244945155 0.0233653959588379 0.0274872375638177 5 True CellOracle_0.18.0_donor_mean_exact_propagation +3 hsc_myofibroblast RUNX2 ETV6 5 4.805539129547783e-05 0.0005593825985372 9.661111407107707e-05 -0.0002799414650086 -0.0003582969747435 -0.0002164708672384 0 False CellOracle_0.18.0_donor_mean_exact_propagation diff --git a/data/perturbation_derived/scgpt/scgpt_donor_level_metrics.tsv b/data/perturbation_derived/scgpt/scgpt_donor_level_metrics.tsv new file mode 100644 index 0000000..728740a --- /dev/null +++ b/data/perturbation_derived/scgpt/scgpt_donor_level_metrics.tsv @@ -0,0 +1,19 @@ +state_slug target matched_control donor adjusted_embedding_rescue adjusted_fra_decoder_rescue +hsc_myofibroblast EFEMP1 TMEM176A cirrhotic1 0.0011578288 0.01946711677555868 +hsc_myofibroblast EFEMP1 TMEM176A cirrhotic2 -0.0009997817 0.026969526747961936 +hsc_myofibroblast EFEMP1 TMEM176A cirrhotic3 -0.00030027478 -0.0015007396529351051 +hsc_myofibroblast EFEMP1 TMEM176A cirrhotic5 -2.85566e-05 0.05558516030820707 +hsc_myofibroblast FOS GAPDH cirrhotic1 -0.0028609224 -0.03526657566221224 +hsc_myofibroblast FOS GAPDH cirrhotic2 -0.0023254557 -0.04395949808504241 +hsc_myofibroblast FOS GAPDH cirrhotic3 0.0024843425 -0.041259636862735934 +hsc_myofibroblast FOS GAPDH cirrhotic4 -0.0053032795 -0.046979190898127854 +hsc_myofibroblast FOS GAPDH cirrhotic5 0.0006780862 -0.040854536921768964 +hsc_myofibroblast JUN MT1E cirrhotic1 0.003696541 0.013306128924402099 +hsc_myofibroblast JUN MT1E cirrhotic2 0.0028939417 0.00709482152795985 +hsc_myofibroblast JUN MT1E cirrhotic3 0.0022834002 0.026914646378097297 +hsc_myofibroblast JUN MT1E cirrhotic4 -0.00050115585 -0.0002460518800136116 +hsc_myofibroblast JUN MT1E cirrhotic5 -0.0023683268 -0.00984182907268405 +hsc_myofibroblast PDGFRA IL1R1 cirrhotic1 0.0006384531 -0.007199573754901808 +hsc_myofibroblast PDGFRA IL1R1 cirrhotic2 -6.453368e-05 0.007830033136997372 +hsc_myofibroblast PDGFRA IL1R1 cirrhotic3 0.0008735731 0.0002724246455944099 +hsc_myofibroblast PDGFRA IL1R1 cirrhotic5 -0.0025049231 0.018146433518268168 diff --git a/data/perturbation_derived/scgpt/scgpt_v16_hsc_control_perturb.tsv b/data/perturbation_derived/scgpt/scgpt_v16_hsc_control_perturb.tsv new file mode 100644 index 0000000..721b860 --- /dev/null +++ b/data/perturbation_derived/scgpt/scgpt_v16_hsc_control_perturb.tsv @@ -0,0 +1,5 @@ +state_slug target matched_control n_donors mean_adjusted_embedding_rescue adjusted_embedding_rescue_ci_low adjusted_embedding_rescue_ci_high mean_adjusted_fra_decoder_rescue adjusted_fra_decoder_rescue_ci_low adjusted_fra_decoder_rescue_ci_high embedding_rescue_supported fra_decoder_rescue_supported control matching_distance cirrhotic_codetection target_mean_count control_mean_count target_detection control_detection expected_ko_direction directional_prediction_pass gpu_name torch_version peak_gpu_memory_bytes +hsc_myofibroblast EFEMP1 TMEM176A 4 -4.269605e-05 -0.0007569753797724843 0.000793302955571562 0.025130266044698146 0.005616826947289154 0.04655564942504497 False True TMEM176A 0.18493870301986276 0.7233009708737864 1.7597028 1.6931593 0.380776340110907 0.3585951940850287 rescue_expected False NVIDIA GeForce RTX 5090 2.7.1+cu128 472721920 +hsc_myofibroblast FOS GAPDH 5 -0.0014654459 -0.0037307715974748135 0.0009268181165680289 -0.04166388768597748 -0.044691369283971084 -0.03812275239868962 False False GAPDH 0.09153432788822058 0.9821782178217822 13.804057 14.353045 0.9334565619223743 0.9796672828096207 rescue_expected False NVIDIA GeForce RTX 5090 2.7.1+cu128 472721920 +hsc_myofibroblast JUN MT1E 5 0.00120088 -0.0009424388408660889 0.003092873143032193 0.007445543175552316 -0.003293082034732732 0.018749535905880178 False False MT1E 0.08524411868927267 0.8626609442060086 7.5970373 7.724577 0.8613678373382698 0.8632162661737597 rescue_expected True NVIDIA GeForce RTX 5090 2.7.1+cu128 472721920 +hsc_myofibroblast PDGFRA IL1R1 4 -0.00026435766 -0.0017190792132169008 0.0007560130907222629 0.004762329386489536 -0.003463574554653699 0.013677931300099729 False False IL1R1 0.2663165531199108 0.567741935483871 0.56192213 0.6062842 0.2865064695009243 0.264325323475046 rescue_expected False NVIDIA GeForce RTX 5090 2.7.1+cu128 472721920 diff --git a/docs/DATA_DICTIONARY.md b/docs/DATA_DICTIONARY.md new file mode 100644 index 0000000..3a09840 --- /dev/null +++ b/docs/DATA_DICTIONARY.md @@ -0,0 +1,69 @@ +# Data dictionary + +## Clinical aggregate tables + +- `Table1_baseline_8142.tsv`: baseline variables, overall summaries, stiffness-stratum summaries, and standardized mean differences. +- `clinical_validation_metrics.tsv`: derivation, temporal-validation, and department-based transport AUROC and calibration metrics. +- `longitudinal_state_flow.tsv`: counts and percentages for low/high LSM state transitions among 772 longitudinal patients. +- `longitudinal_outcomes.tsv`: aggregate persistence and regression categories. +- `serum_imbalance_associations.tsv`: odds ratios, confidence intervals, P values, and AUROC estimates for the frozen serum proxy and component axes. +- `clinical_analysis_summary.json`: frozen cohort totals, thresholds, and summary estimates used in the manuscript. +- `legacy_compatible/`: aggregate model and donor-burden source tables retained for supplementary figures. + +## Flow-cytometry aggregate tables + +- `flow_analysis_summary.json`: cohort-level panel and patient counts plus the declared manuscript role. +- `flow_context_counts.tsv`: panels and patients by broad clinical context; minimum released group size is 10 patients. +- `flow_context_models.tsv`: aggregate effect estimates for immune features by context. +- `flow_immune_pca_loadings.tsv`: principal-component loadings for the six-marker immune panel. + +The individual flow-elastography linkage table is intentionally absent. + +## UQ spatial data + +Files in `UQ_resolver_source_inputs` contain public-resource spot, biopsy, module, and sensitivity summaries generated before the final S10-S14 analyses. + +Files in `UQ_spatial_derived` contain: + +- S10: proteolytic-lock module scores, detection audits, biopsy coupling, and cross-module summaries. +- S11: repair-retention axes, static Gaussian-mixture model selection, patient/bootstrap sensitivity, spatial blocks, and component assignments. +- S12: order-aware LINCS pair scores and weighting sensitivity. +- S13: mouse module mapping, phase scores, exact tests, and trajectory geometry. +- S14: retention-domain topology, equal-posterior-boundary profiles, boundary effects, threshold sensitivity, and spot annotations. + +## Figure-reconstruction inputs + +- `integrated_retention_candidates.tsv`: categorical HSC evidence fields used in revised Figure 3. +- `LAM_priority_gene_fates.tsv`: macrophage repair-gene fate fields used in revised Figure 3. +- `UQ_CODEX_scar_enrichment.tsv`: three section-specific CODEX enrichment estimates used in revised Figure 4. +- The static GMM, mouse, and order-aware replacement panels read the corresponding S11-S13 files above. + +## Mechanism evidence inputs + +- `data/mechanism_summary/mechanism_edge_evidence.tsv`: one row per displayed circuit edge, with relationship direction, evidence class, project source, literature reference or DOI, and a direct-test flag. +- `figures/source_panels/Fig7*.svg`: editable Figure 7 source panels used by the main-plate compositor. + +## Methods-audit files + +`docs/methods_audit/` contains the dataset master table, GSE306327 sample notes, UQ reconstruction audit, drug-score specification, dated analysis timeline, panel-statistics workbook, and machine-readable supporting tables. Audit labels distinguish documented facts, chronology-based inference, and information not documented in the archived workspace. + +## Common statistical fields + +- `estimate`, `effect`, `slope`, `coef`: estimated effect in the scale documented by the file or generating script. +- `se`: standard error. +- `ci_low`, `ci_high`: confidence-interval bounds. +- `p`, `p_value`, `exact_*_p`: nominal or exact P value. +- `q`, `fdr`: multiplicity-adjusted P value where calculated. +- `n`, `n_patients`, `n_biopsies`, `n_observations`: biological or observational unit count. +- `stage`: fibrosis stage as encoded by the public source resource. +- `patient`, `biopsy`, `array`, `barcode`: public-resource identifiers, not proprietary clinical identifiers. + +Exact formulas, module membership, seeds, and file-level assumptions are preserved in the corresponding scripts. + +## Figure files + +- `figures/main/Figure_*.png` and `Figure_*.pdf`: seven revised composite main figures. +- `figures/main/Figure_{1,2,5,7}_*.svg`: editable main-figure plates. +- `figures/reviewer_revision/Fig*.{png,pdf,svg}`: four corrected analytical panels and source manifest. +- `figures/supplementary/Supplementary_Figure_S1.png` through `Supplementary_Figure_S30_UQ_Mapping_Sensitivity.png`: complete supplementary figure atlas. +- `FIGURE_SOURCE_MAP.md`: links each main display to the released source-data families and states its reproduction boundary. diff --git a/docs/FIGURE_SOURCE_MAP.md b/docs/FIGURE_SOURCE_MAP.md new file mode 100644 index 0000000..d29cd08 --- /dev/null +++ b/docs/FIGURE_SOURCE_MAP.md @@ -0,0 +1,28 @@ +# Figure-to-source map + +Panel-level details are machine-readable in `PANEL_PROVENANCE.tsv`. The accompanying audit workbook records sample sizes, biological units, transformations, uncertainty, scripts, source outputs, and the correction made after peer review. + +| Figure | Principal content | Public files | Inference boundary | +|---|---|---|---| +| 1 | Clinical cohort, CAP-LSM states, validation, longitudinal transitions, serum proxy | `data/clinical_aggregate/*`; `code/governed_clinical_transparency/rebuild_final_clinical_visuals.py` | Patient-level inputs are governed; the released serum association is exploratory and univariable | +| 2 | Replicated withdrawal geometry and descriptive resolver timing | `data/mouse_pseudobulk_derived/*`; `data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/*` | GSE295293 uses nine mice; GSE305331 uses seven pooled condition libraries and has no replicate-level inference | +| 3 | Functional persistence atlas and categorical cross-compartment evidence | `data/figure_reconstruction/*`; public accessions in `RAW_DATA_ACCESSIONS.md` | Cell-level displays are descriptive; donor or animal is the biological unit in supporting analyses; no shared numeric evidence scale is asserted | +| 4 | HSC-retention coupling to human scar and descriptive CODEX concordance | `data/UQ_resolver_source_inputs/*`; `data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/*`; `data/figure_reconstruction/UQ_CODEX_scar_enrichment.tsv` | Visium stage tests aggregate to 32 patient clusters; CODEX contains one section per displayed stage | +| 5 | Retention-domain coalescence and repair-interface contraction | `data/UQ_spatial_derived/S11_UQ_phase_basin_control/*`; `data/UQ_spatial_derived/S14_spatial_domain_wall/*` | Display posterior 0.67 and topology threshold 0.50 have distinct roles; patient clusters are the stage-level unit | +| 6 | Static two-component spatial distribution and incomplete mouse return | `data/UQ_spatial_derived/S11_UQ_phase_basin_control/*`; `data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/*` | The GMM is static; no physical potential, flow field, or hysteresis parameter was estimated | +| 7 | Evidence-coded candidate mechanism, in-silico perturbation, compound screen, and order-aware nomination | `data/mechanism_summary/mechanism_edge_evidence.tsv`; `data/LINCS_derived/*`; `data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/*`; `figures/source_panels/*` | Edge styles distinguish established literature, project-supported association, and directly testable candidate links; the asymmetric scoring rule ranks role assignments and is not an observed treatment-order or efficacy estimate | + +## Revised figure formats + +All seven main figures are provided in PNG and PDF. Figures 1, 2, 5, and 7 also have editable SVG plates. The corrected analytical panels for Figures 3, 4, 6, and 7 are separately provided as editable SVG, PDF, and PNG under `figures/reviewer_revision/`; the four Figure 7 source panels are under `figures/source_panels/`. + +## Numerical anchors + +- Adult index cohort: 8,142 patients. +- Longitudinal state-flow cohort: 772 patients. +- Human UQ spatial analysis: 13,585 spots, 33 biopsy fragments, 32 patient clusters, and 589 spatial blocks. +- One- versus two-component BIC gain: 141.012. +- Largest retention-domain stage slope: +0.0960 per stage. +- Cross-state interface stage slope: -0.0287 per stage. +- Mouse withdrawal residual distance: 69.8% of peak-fibrosis displacement. +- Ezetimibe-to-verteporfin versus reverse order-aware scores: 0.892 versus 0.504; computational nomination only. diff --git a/docs/METHODS_AUDIT_SUMMARY.md b/docs/METHODS_AUDIT_SUMMARY.md new file mode 100644 index 0000000..1eb349d --- /dev/null +++ b/docs/METHODS_AUDIT_SUMMARY.md @@ -0,0 +1,25 @@ +# Methods audit summary + +This release distinguishes documented analysis facts from chronology-based inference and from information absent in the archive. + +## Corrections incorporated + +1. The four-part prediction framework is reported as the final analytical organization. The archive does not support prospective preregistration of the final wording. +2. GSE305331 comprises seven pooled condition libraries, each pooling three mice. Its 543,639 nuclei are technical observations and the timing display is descriptive. +3. UQ geometry and biopsy registration preceded module-score generation in the archived run. Strict operator blinding to ECM, retention, and repair information is not documented. +4. Figure 3 no longer places HSC weighted evidence tallies and macrophage effect-derived values on one numeric scale. +5. CODEX has one section at each displayed stage; its three estimates are presented independently without a stage-trend line. +6. The human two-component analysis is a static full-covariance Gaussian-mixture model. Potential, flow, and hysteresis language has been removed. +7. The LINCS forward-reverse difference follows from an asymmetric role-weighted formula. It nominates a factorial experiment and does not estimate an observed order effect. +8. Safety and computational annotations were not enforced by the archived pair-generation script and are not described as hard gates. + +## Audit files + +- `Dataset_Master_Table.xlsx`: dataset structure, unit, sample count, role, and limitations. +- `GSE306327_Methods_Notes.docx`: sample structure and exact analysis notes. +- `UQ_Reconstruction_Audit.xlsx`: geometry, registration, score timing, and blinding assessment. +- `Drug_Order_Scoring_Specification.docx`: formulas, thresholds, candidate rules, and 27 weight schemes. +- `Prespecification_and_Analysis_Timeline.docx`: dated classification of planned, refined, and post-hoc analyses. +- `Figure_Panel_Statistics.xlsx`: panel-level statistics and units. +- `Reviewer_Response_and_Repair_Matrix.xlsx`: rejection issue, verified cause, evidence, correction, and acceptance criterion. +- `machine_readable/`: TSV and compressed all-pair records supporting the audit. diff --git a/docs/PANEL_PROVENANCE.tsv b/docs/PANEL_PROVENANCE.tsv new file mode 100644 index 0000000..4126cc9 --- /dev/null +++ b/docs/PANEL_PROVENANCE.tsv @@ -0,0 +1,17 @@ +panel dataset biological_unit n plotted_quantity exact_method uncertainty_or_test script source_output inference_boundary +Fig1A-E Institutional elastography cohort patient 8142 cohort flow, baseline distributions, CAP-LSM states, marker prevalence adult first eligible examination after technical QC; CAP 280 dB/m and LSM 9.5 kPa state thresholds descriptive counts and percentages code/governed_clinical_transparency/rebuild_final_clinical_visuals.py data/clinical_aggregate/Table1_baseline_8142.tsv; clinical_analysis_summary.json participant-level data governed +Fig1F Institutional elastography cohort patient 4525 development; 3617 temporal; 2286 transport test AUROC for LSM >=9.5 kPa StandardScaler plus L2 logistic regression, default C=1.0 and lbfgs, predictors age sex BMI CAP; shuffled stratified five-fold OOF development; locked temporal application 1200 patient bootstraps; percentile 95% CI; Brier score code/governed_clinical_transparency/rebuild_final_clinical_visuals.py data/clinical_aggregate/clinical_validation_metrics.tsv departmental analysis is a separate transport test +Fig1H-K Institutional longitudinal elastography cohort patient 772 four-state transitions and threshold persistence first and last eligible examinations separated by at least 90 days; CAP 280 and LSM 9.5 thresholds descriptive counts and proportions code/governed_clinical_transparency/rebuild_final_clinical_visuals.py data/clinical_aggregate/longitudinal_state_flow.tsv; longitudinal_outcomes.tsv observational association +Fig1L Linked serum complete cases patient 46 standardized univariable odds ratios frozen rank-normalized aggregate proxy binomial GLM Wald 95% CI code/governed_clinical_transparency/rebuild_final_clinical_visuals.py data/clinical_aggregate/serum_imbalance_associations.tsv exploratory and univariable +Fig2A-B GSE295293 mouse 9; 3 per group animal-pseudobulk progression, withdrawal, and residual log2 fold changes edgeR filterByExpr, TMM, robust quasi-likelihood negative-binomial contrasts; persistence requires progression FDR <0.10, abs log2FC >=0.5, same residual direction, residual FDR <0.10, at least 50% retained BH FDR; exact 1680 allocation tests for trajectory summaries code/public_mechanism/mouse_resolver_lock_trajectory.py data/mouse_pseudobulk_derived/*; data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/* animal is the inferential unit +Fig2C-D GSE305331 pooled condition library 7 libraries; 3 mice pooled per library condition-level module trajectories and standardized resolver/retention proxies resolver proxy is mean Endo4_WNT_resolver and LAM_resolver; HSC-retention proxy is HSC_pathogenic_retention; standardized within etiology descriptive only code/public_mechanism/mouse_resolver_lock_trajectory.py data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE305331_cross_etiology_phase_trajectories.tsv 543639 nuclei are technical observations +Fig3A-B GSE136103 cell for display; donor for biological inference 60721 cells released embedding and marker dot plot frozen processed atlas display descriptive public reconstruction; accession in docs/RAW_DATA_ACCESSIONS.md public source dataset cell-level display does not create replicate-level inference +Fig3C-D GSE244832, GSE295293, source HSC modalities gene evidence across donor- and animal-level analyses 4 HSC candidates; 5 macrophage genes directional evidence matrix, categorical threshold status, persistent-gene chord criterion-specific categorical coding; chord width is clipped absolute residual log2FC mixed source-specific tests; no omnibus evidence magnitude code/reviewer_revision/rebuild_high_risk_panels.py data/figure_reconstruction/integrated_retention_candidates.tsv; LAM_priority_gene_fates.tsv no shared numeric evidence scale +Fig4A-B UQ MASLD Visium patient cluster 33 biopsy fragments; 32 clusters; 13585 spots module means and lineage-adjusted scar-proximity coefficients top 15% structural ECM scar field; 8 x 4 biopsy grid; lineage and library-size adjustment; array fixed effects HC3 SE; 9999 within-array Freedman-Lane permutations; BH across 33 spatial tests code/public_mechanism/UQ_Visium_resolver_window_analysis.py data/UQ_resolver_source_inputs/*; data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/* patient cluster is the stage-level unit +Fig4C-F UQ CODEX section one F1, one F2, one F4 section multiplex fields and section-specific scar enrichment 128 x 128 pixel primary patches with DAPI and tissue coverage covariates; 96 and 160 sensitivity section-level descriptive spatial nulls code/reviewer_revision/rebuild_high_risk_panels.py data/figure_reconstruction/UQ_CODEX_scar_enrichment.tsv no replicated stage trend +Fig5A-K UQ MASLD Visium patient cluster 33 biopsy fragments; 32 clusters posterior state maps, largest retention component, cross-state interfaces, state fractions full-resolution adjacency <=1.25 times median nearest-neighbor distance; display posterior >=0.67; topology cutoff 0.50 with 0.40-0.67 sensitivity array-fixed OLS, HC3, 10000 within-array permutations, BH across four outcomes code/public_mechanism/spatial_domain_wall_resolver_window.py data/UQ_spatial_derived/S11_UQ_phase_basin_control/*; S14_spatial_domain_wall/* display and topology thresholds have different purposes +Fig6A-C UQ MASLD Visium patient cluster 589 blocks; 33 biopsy fragments; 32 clusters static two-component GMM, BIC, component occupancy full-covariance GMM, 1-5 components, 50 starts, seed 20260712 300 patient bootstraps and leave-one-patient-out refits code/reviewer_revision/rebuild_high_risk_panels.py data/UQ_spatial_derived/S11_UQ_phase_basin_control/* no physical potential, flow field, or hysteresis parameter +Fig6D GSE295293 mouse 9; 3 per group group trajectory in standardized repair-retention space animal module-score projection exact group-allocation test where reported code/reviewer_revision/rebuild_high_risk_panels.py data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/* incomplete return geometry, not a fitted dynamical trajectory +Fig7A literature plus project-supported links relationship 24 evidence-coded edges candidate feedback circuit solid gray links are literature-established; dashed berry links are project-supported associations; dotted gold links are candidates for direct testing edge-specific evidence class, project result, DOI, and direct-test flag code/figures/build_mechanism_circuit.py data/mechanism_summary/mechanism_edge_evidence.tsv; figures/source_panels/Fig7A_Evidence_Coded_Mechanism.svg hypothesis model; candidate edges are not treated as established causal links +Fig7B scGPT, CellOracle, LINCS donor or matched signature context platform-specific in-silico target effects target value ablation, network knockout simulation, matched-context L1000 direction check 5000 donor bootstraps or platform-specific nulls code/perturbation/* data/perturbation_derived/* platform scales differ; no experimental genetic perturbation +Fig7C-D LINCS L1000 signature, compound, pair 8632 signatures; 575 compounds; 394 eligible; 299 different-compound pairs dual-axis compound score and asymmetric order-aware pair score 20 early-role and 15 late-role candidates; one self-pair excluded; 27 weight schemes rank and weight sensitivity code/public_mechanism/sequential_basin_switch_drugs.py; code/reviewer_revision/rebuild_high_risk_panels.py data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/*; docs/methods_audit/machine_readable/Drug_Order_Complete_Results.tsv computational nomination; gates not enforced in pair generation diff --git a/docs/PRIVACY_AND_GOVERNANCE.md b/docs/PRIVACY_AND_GOVERNANCE.md new file mode 100644 index 0000000..db4269b --- /dev/null +++ b/docs/PRIVACY_AND_GOVERNANCE.md @@ -0,0 +1,27 @@ +# Privacy and governance boundary + +## Public content + +The clinical files in this release contain aggregate counts, coefficients, confidence intervals, performance metrics, and summary statistics. They contain no row-level patient records, encounter dates, dates of birth, medical-record numbers, names, contact details, addresses, or hashed identifiers. + +The public-data molecular files contain derived measurements indexed by public repository samples, biopsies, arrays, spatial spots, perturbations, or model iterations. These identifiers trace to already public scientific resources. + +The figure directories contain publication composites generated from the released aggregate/derived results and public scientific resources. The AI-generated graphical-abstract concept produced during internal design exploration is excluded. + +## Withheld content + +The following content remains under institutional governance and is not included: + +- Patient-level elastography, laboratory, diagnostic, and longitudinal records. +- The verified clinical linkage key and all direct or transformed identifiers. +- The one-record flow-cytometry to elastography linkage table. +- Ethics approvals, continuing-review documents, consent records, and author contact files. +- Internal server addresses, credentials, proxy subscriptions, and local infrastructure notes. + +The governed workflow scripts retain generic references to controlled input classes and transformations for auditability. They contain no controlled input, linkage key, hashing salt value, or participant record. + +## Disclosure control + +Clinical output was restricted to aggregate tables. The smallest contextual group in the released flow summaries contains 10 patients. A single linked flow record was excluded even though its identifiers had been hashed because the combination of one individual and detailed measurements remained disclosure-prone. + +Zenodo does not anonymize files on behalf of depositors. This package therefore contains only the pre-screened open subset. Any future release of participant-level information requires an institutional data-access mechanism rather than an unrestricted Zenodo upload. diff --git a/docs/PUBLIC_RELEASE_CHECKLIST.md b/docs/PUBLIC_RELEASE_CHECKLIST.md new file mode 100644 index 0000000..c998d2e --- /dev/null +++ b/docs/PUBLIC_RELEASE_CHECKLIST.md @@ -0,0 +1,25 @@ +# Public release checklist + +## Required before publication + +- [ ] Every author approves authorship order, CRediT roles, licenses, repository contents, and public release. +- [ ] Continuing ethics coverage and the exact consent/waiver wording are confirmed for the full clinical-data period. +- [x] The repository owner/name replaces the GitHub placeholder in `CITATION.cff`. +- [x] The reserved Zenodo DOI replaces the DOI placeholder in `CITATION.cff`. +- [x] The same DOI is inserted into the manuscript's Data availability and Code availability statements. +- [ ] The final manuscript title and repository title match. +- [x] `python scripts/validate_release.py` exits successfully. +- [x] `SHA256SUMS.txt` and `FILE_MANIFEST.txt` are regenerated after the last change. +- [x] The release archive checksum is recorded outside the archive. +- [ ] A second author manually inspects `data/clinical_aggregate/` and `data/flow_aggregate/`. +- [x] The `release/v2.1.0-rc1` branch remains unmerged until the Zenodo record and manuscript metadata are synchronized. + +## Never add + +- Participant-level clinical or flow records. +- Exact dates linked to participants, dates of birth, names, medical-record numbers, identity-card numbers, addresses, telephone numbers, or hashes derived from identifiers. +- The verified clinical linkage key or flow-elastography linkage table. +- Ethics approval PDFs, consent forms, or author-private files. +- SSH credentials, server hostnames, proxy subscriptions, API keys, or local infrastructure notes. +- Public raw sequencing/imaging archives, LINCS Level 5 matrices, or model weights that should be downloaded from their original hosts. +- AI-generated graphical-abstract or mechanism concept images. diff --git a/docs/RAW_DATA_ACCESSIONS.md b/docs/RAW_DATA_ACCESSIONS.md new file mode 100644 index 0000000..be851d2 --- /dev/null +++ b/docs/RAW_DATA_ACCESSIONS.md @@ -0,0 +1,28 @@ +# Public raw-data accessions + +Large public raw data are intentionally not redistributed. Reconstruct them from the original repositories and cite the source studies. + +## GEO + +- GSE295293: replicated control, peak-fibrosis, and withdrawal mouse liver single-cell data. +- GSE305331: pooled cross-etiology CCl4 and FAT-MASH withdrawal series. +- GSE261829: Foz/Foz MASH regression macrophage system. +- GSE244832: human NORMAL, MASL, and MASH snRNA-seq/snATAC-seq. +- GSE136103: human healthy and cirrhotic liver single-cell atlas. +- GSE278662: human liver Visium sections used for reaction-front sensitivity analyses. +- GSE48325 and GSE48452: bariatric-surgery methylation/expression resources used for paired sensitivity analyses. +- GSE33650, GSE135251, and GSE162694: external human bulk or biopsy-stage resources. +- GSE305330 and GSE306327: pooled or spatial withdrawal resources retained in Extended Data analyses. +- GSE92742: LINCS L1000 perturbation compendium used for genetic and compound-signature analyses. + +GEO landing-page pattern: `https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=ACCESSION` + +## UQ MASLD spatial resource + +- Data DOI: https://doi.org/10.48610/e95155f +- Source analysis repository: https://github.com/BiomedicalMachineLearning/Liver + +## LINCS L1000 + +- Connectivity Map/L1000 source study: https://doi.org/10.1016/j.cell.2017.10.049 +- Raw Level 5 matrices are not included in this release. diff --git a/docs/REPOSITORY_UPLOAD_GUIDE.md b/docs/REPOSITORY_UPLOAD_GUIDE.md new file mode 100644 index 0000000..1c694c6 --- /dev/null +++ b/docs/REPOSITORY_UPLOAD_GUIDE.md @@ -0,0 +1,34 @@ +# Repository and DOI release guide + +## Recommended sequence + +1. Push the contents of this directory to `release/v2.1.0-rc1` in `LightChainr/PathoNiche-ResolverWindow`. +2. Open a pull request against `main` and leave it unmerged while the new Zenodo version is prepared. +3. Run `python scripts/validate_release.py --rebuild` in a clean checkout of the release branch. +4. Complete `PUBLIC_RELEASE_CHECKLIST.md` with a second author. +5. Use the Zenodo new-version draft with reserved DOI `10.5281/zenodo.22138229`. +6. Verify the GitHub URL and DOI in `CITATION.cff` and the manuscript availability statements. +7. Regenerate `FILE_MANIFEST.txt`, `SHA256SUMS.txt`, and the ZIP archive. +8. Merge the reviewed release branch and tag the resulting commit `v2.1.0`. +9. Publish the Zenodo record after the GitHub and manuscript metadata agree. + +## Suggested repository settings + +- Default branch: `main`. +- Visibility before release: private. +- Issues: enabled for reproducibility questions. +- Wiki and Discussions: optional. +- Branch protection: require one approval for `main` after public release. +- Large-file storage: unnecessary for the current package; do not add raw public datasets. + +## Final metadata to add + +- Reserved Zenodo DOI. +- Final repository URL. +- Confirmed ORCID identifiers, when supplied by each author. +- Related preprint DOI and journal DOI when available. +- Final release date and version without the `rc` suffix. + +## Release description + +Use the opening paragraph of `README.md`, followed by the five-point scientific scope and the explicit exclusion statement. State that participant-level clinical data are available only through an institutionally governed access process, if such a process is formally established. diff --git a/docs/REPRODUCIBILITY.md b/docs/REPRODUCIBILITY.md new file mode 100644 index 0000000..9e2efa0 --- /dev/null +++ b/docs/REPRODUCIBILITY.md @@ -0,0 +1,81 @@ +# Reproducibility notes + +## Release-level audit + +Create a clean Python environment and run: + +```bash +python3 -m venv .venv +source .venv/bin/activate +python -m pip install -r environment/requirements.txt +python scripts/validate_release.py +``` + +This validates the public package and its principal numerical anchors. It does not reconstruct raw public data or governed patient-level analyses. + +## Reviewer-facing panel reconstruction + +The four panels revised after peer review rebuild directly from included derived inputs: + +```bash +python code/reviewer_revision/rebuild_high_risk_panels.py +``` + +Expected outputs are written to `figures/reviewer_revision/`. They replace an incompatible mixed evidence scale in Figure 3, a pseudo-replicated CODEX stage line in Figure 4, unestimated dynamics in Figure 6, and an overinterpreted order-score display in Figure 7. + +The evidence-coded mechanism panel and editable main SVG plates rebuild with: + +```bash +python code/figures/build_mechanism_circuit.py +python code/figures/rebuild_main_figure_plates.py +``` + +## Public mechanism workflow + +The final analysis order was: + +1. `UQ_Visium_resolver_window_analysis.py` +2. `uq_spatial_proteolytic_lock.py` +3. `uq_phase_basin_control.py` +4. `spatial_domain_wall_resolver_window.py` +5. `mouse_resolver_lock_trajectory.py` +6. `sequential_basin_switch_drugs.py` + +The public-mechanism scripts are frozen provenance snapshots. Module definitions, thresholds, seeds, biological-unit handling, and statistical tests are retained. Some original workflow scripts require raw public archives that are intentionally excluded. Map those logical inputs to the following resources: + +| Logical input | Public reconstruction source | Included shortcut | +|---|---|---| +| UQ Visium filtered matrices and spatial metadata | DOI `10.48610/e95155f` | Derived module/spot tables under `data/UQ_resolver_source_inputs/` | +| UQ S10 proteolytic-lock results | Output of step 2 | `data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/` | +| UQ S11 phase/basin results | Output of step 3 | `data/UQ_spatial_derived/S11_UQ_phase_basin_control/` | +| GSE295293 pseudobulk | GEO reconstruction | `data/mouse_pseudobulk_derived/` | +| GSE305331 pooled trajectories | GEO reconstruction | `data/mouse_pseudobulk_derived/state_module_trajectories.tsv` | +| LINCS hard-gated compound table | GSE92742/LINCS reconstruction | `data/LINCS_derived/LINCS_name_collapsed_hard_gated.tsv` | + +Any change to module membership, thresholds, seeds, or analysis units should be declared as a sensitivity analysis rather than a reproduction. + +## Chronology and exploratory status + +The four-part framework was finalized after core analyses and is not represented as prospective preregistration. UQ component geometry and biopsy registration preceded score generation in the archived run, but strict analyst blinding is not documented. The order-aware pair script uses an asymmetric role-weighted formula and did not enforce the archived safety or computational hard gates during pair generation. These facts and their source timestamps are recorded under `docs/methods_audit/`. + +## What can be verified immediately + +The included JSON/TSV/Parquet files permit direct inspection of: + +- cohort and longitudinal totals; +- clinical aggregate associations and validation metrics; +- spatial coupling, stage trends, threshold sensitivity, and biopsy summaries; +- two-component model selection and leave-one-patient-out stability; +- retention-domain topology and interface contraction; +- geometry-only biopsy reconstruction and mapping sensitivity; +- edge-level mechanism evidence classes and direct-test flags; +- replicated mouse withdrawal geometry; +- LINCS eligibility, ordered-pair scores, and weight sensitivity. + +## Governed clinical workflow + +`code/governed_clinical_transparency/` documents the institutional workflow and expected transformations. It references controlled inputs such as the verified clinical linkage table and the institutional hashing salt. Those inputs are intentionally absent. The scripts cannot be executed from this public repository and must not be modified to imply public availability of participant-level data. + +## Public raw-data reconstruction + +Large sequencing, imaging, LINCS, and model files are excluded. Obtain them from the original repositories listed in `RAW_DATA_ACCESSIONS.md`, retain their original identifiers, and cite the source studies. Source terms continue to apply. diff --git a/docs/WORKFLOW_ENTRYPOINTS.md b/docs/WORKFLOW_ENTRYPOINTS.md new file mode 100644 index 0000000..e324cea --- /dev/null +++ b/docs/WORKFLOW_ENTRYPOINTS.md @@ -0,0 +1,121 @@ +# Workflow entry points + +All commands are run from the repository root. Public raw datasets are intentionally omitted and should be placed under `data/raw_external/` or supplied through explicit command-line paths. + +## Environment and validation + +```bash +uv venv --python 3.11 .venv +uv pip sync --python .venv/bin/python environment/requirements-lock.txt +.venv/bin/python scripts/validate_release.py --rebuild +``` + +## GSE295293 mouse progression and withdrawal + +```bash +.venv/bin/python code/mouse/GSE295293_prepare_pseudobulk.py \ + --archive data/raw_external/GSE295293/GSE295293_RAW.tar \ + --work-dir work/GSE295293 \ + --output-dir results/GSE295293_dynamic_regression + +Rscript code/mouse/GSE295293_dynamic_pseudobulk.R \ + --input-dir work/GSE295293 \ + --output-dir results/GSE295293_dynamic_regression + +.venv/bin/python code/mouse/mouse_resolver_lock_trajectory.py \ + --counts work/GSE295293/pseudobulk_counts.tsv.gz \ + --metadata work/GSE295293/pseudobulk_metadata.tsv \ + --pooled-trajectories results/GSE305331_state_trajectories/state_module_trajectories.tsv \ + --output-dir results/S13_mouse_resolver_retention_trajectory +``` + +The inferential unit for GSE295293 is the mouse. GSE305331 contains one pooled library per condition and supports descriptive timing only. + +## GSE244832 human HSC donor pseudobulk + +```bash +.venv/bin/python code/human_hsc/GSE244832_prepare_hsc_map.py \ + --source-dir data/raw_external/GSE244832 \ + --output-dir work/GSE244832_hsc_pseudobulk + +c++ -O3 -std=c++17 code/human_hsc/GSE244832_stream_hsc_pseudobulk.cpp -o work/stream_hsc +gzip -cd data/raw_external/GSE244832/hLIVER_counts.mtx.gz | work/stream_hsc \ + work/GSE244832_hsc_pseudobulk/cell_map.tsv \ + work/GSE244832_hsc_pseudobulk/genes.tsv \ + work/GSE244832_hsc_pseudobulk/hsc_pseudobulk_counts.tsv \ + work/GSE244832_hsc_pseudobulk/stream_audit.tsv + +Rscript code/human_hsc/GSE244832_hsc_donor_edger.R \ + --input-dir work/GSE244832_hsc_pseudobulk \ + --output-dir results/GSE244832_hsc_donor +``` + +## GSE136103 atlas + +```bash +.venv/bin/python code/atlas/m2_gse136103_build_h5ad.py \ + --raw-dir data/raw_external/GSE136103 \ + --output-dir results/GSE136103_atlas + +.venv/bin/python code/atlas/m2_gse136103_scanpy_cluster_signature.py \ + --input-h5ad results/GSE136103_atlas/GSE136103_human_liver_filtered_qc_v1.h5ad \ + --output-dir results/GSE136103_atlas \ + --threads 8 + +.venv/bin/python code/atlas/m2_gse136103_cell_state_label_v1.py \ + --input-h5ad results/GSE136103_atlas/GSE136103_human_liver_scanpy_clustered_v1.h5ad \ + --output-dir results/GSE136103_atlas + +.venv/bin/python code/atlas/m2_gse136103_cell_state_pseudobulk_de.py \ + --input-h5ad results/GSE136103_atlas/GSE136103_human_liver_cell_state_labels_v1.h5ad \ + --output-dir results/GSE136103_atlas +``` + +Cell-level embeddings are descriptive. Disease comparisons aggregate by donor. + +## UQ Visium and spatial retention domains + +```bash +.venv/bin/python code/spatial/UQ_Visium_component_audit.py --help +.venv/bin/python code/spatial/UQ_Visium_resolver_window_analysis.py --help + +.venv/bin/python code/spatial/uq_phase_basin_control.py \ + --input data/UQ_spatial_derived/S10_UQ_spatial_proteolytic_lock/UQ_proteolytic_lock_spot_scores.parquet \ + --output-dir results/S11_UQ_static_component_control + +.venv/bin/python code/spatial/spatial_domain_wall_resolver_window.py \ + --input results/S11_UQ_static_component_control/phase_spot_states.parquet \ + --output-dir results/S14_spatial_retention_domains + +.venv/bin/python code/spatial/UQ_Visium_component_audit.py \ + --visium-root data/raw_external/UQ_Visium \ + --results-dir data/UQ_spatial_mapping_derived \ + --figures-dir results/S15_UQ_biopsy_mapping_sensitivity/geometry + +.venv/bin/python code/spatial/UQ_biopsy_mapping_sensitivity.py \ + --phase-spots data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spot_states.parquet \ + --component-map data/UQ_spatial_mapping_derived/UQ_Visium_spot_component_map.parquet \ + --biopsy-map docs/methods_audit/machine_readable/UQ_Biopsy_Reconstruction_Map.tsv \ + --output-dir results/S15_UQ_biopsy_mapping_sensitivity +``` + +The two-component model is a static distributional model. Retention-domain topology uses the posterior threshold and spatial adjacency rules recorded in panel provenance. The mapping audit assigns connected components from array coordinates only; score columns do not enter biopsy assignment. Its stress tests remove fragment rescues, split geometric components, exclude inferred or merged fields, and leave out each array. + +## LINCS order-aware nomination + +```bash +.venv/bin/python code/perturbation/sequential_basin_switch_drugs.py \ + --input data/LINCS_derived/LINCS_name_collapsed_hard_gated.tsv \ + --output-dir results/S12_order_aware_drug_nomination +``` + +The asymmetric score nominates an equal-exposure factorial experiment. scGPT and CellOracle use dedicated environments documented under `environment/` and are excluded from the core lock. + +## Evidence-coded mechanism and main SVG plates + +```bash +.venv/bin/python code/figures/build_mechanism_circuit.py +.venv/bin/python code/figures/rebuild_main_figure_plates.py +``` + +The mechanism circuit reads `data/mechanism_summary/mechanism_edge_evidence.tsv`. Solid links are literature-established, dashed links are project-supported associations, and dotted links are candidates for direct testing. The plate builder applies the manuscript terminology and composes Figure 7 from the four editable source panels. diff --git a/docs/methods_audit/Dataset_Master_Table.xlsx b/docs/methods_audit/Dataset_Master_Table.xlsx new file mode 100644 index 0000000..6341225 Binary files /dev/null and b/docs/methods_audit/Dataset_Master_Table.xlsx differ diff --git a/docs/methods_audit/Drug_Order_Scoring_Specification.docx b/docs/methods_audit/Drug_Order_Scoring_Specification.docx new file mode 100644 index 0000000..f629e14 Binary files /dev/null and b/docs/methods_audit/Drug_Order_Scoring_Specification.docx differ diff --git a/docs/methods_audit/Figure_Panel_Statistics.xlsx b/docs/methods_audit/Figure_Panel_Statistics.xlsx new file mode 100644 index 0000000..a285fcc Binary files /dev/null and b/docs/methods_audit/Figure_Panel_Statistics.xlsx differ diff --git a/docs/methods_audit/GSE306327_Methods_Notes.docx b/docs/methods_audit/GSE306327_Methods_Notes.docx new file mode 100644 index 0000000..ac9971c Binary files /dev/null and b/docs/methods_audit/GSE306327_Methods_Notes.docx differ diff --git a/docs/methods_audit/Prespecification_and_Analysis_Timeline.docx b/docs/methods_audit/Prespecification_and_Analysis_Timeline.docx new file mode 100644 index 0000000..cd5a7c0 Binary files /dev/null and b/docs/methods_audit/Prespecification_and_Analysis_Timeline.docx differ diff --git a/docs/methods_audit/Reviewer_Response_and_Repair_Matrix.xlsx b/docs/methods_audit/Reviewer_Response_and_Repair_Matrix.xlsx new file mode 100644 index 0000000..5bf7dd9 Binary files /dev/null and b/docs/methods_audit/Reviewer_Response_and_Repair_Matrix.xlsx differ diff --git a/docs/methods_audit/UQ_BIOPSY_RECONSTRUCTION_PROVENANCE.md b/docs/methods_audit/UQ_BIOPSY_RECONSTRUCTION_PROVENANCE.md new file mode 100644 index 0000000..5bc3cb1 --- /dev/null +++ b/docs/methods_audit/UQ_BIOPSY_RECONSTRUCTION_PROVENANCE.md @@ -0,0 +1,42 @@ +# UQ biopsy reconstruction provenance + +## Source record + +- The source paper reports 33 Visium liver biopsies from 32 patients, including two synchronous cores from one patient. +- The published Supplementary Figure S1E displays all biopsy-shaped spot fields coloured by fibrosis stage. The local source is `mmc1.pdf`, page 14, with the panel legend on page 15. +- The source `QC and normalisation` script loads eight arrays and reads one per-spot `*_samples.csv` file per array before any module scores are calculated. It then assigns the published fibrosis stages to 33 named biopsy samples. +- The source `Integration` script independently lists the same 33 patient labels and fibrosis factors and composes the 2 x 4 array layout used in Supplementary Figure S1E. +- The archived reconstruction table contains 33 biopsy entries, 32 patient clusters, 14 early, 5 intermediate, and 14 late biopsies, matching the paper. + +## Reproducible geometry + +`code/spatial/UQ_Visium_component_audit.py` constructs connected components from `array_row` and `array_col` only. It does not read expression values or module scores. The current rerun recovered 43 components across the eight published arrays. + +`code/spatial/UQ_biopsy_mapping_sensitivity.py` compared this geometry-only reconstruction with the archived component and biopsy assignments. It recovered 13,539 analysis spots directly from connected components with 100% component-label agreement. Forty-six spots in small disconnected fragments had been assigned to the nearest registered component. The script excludes those spots in a dedicated sensitivity analysis. + +## Registration evidence + +The component-to-biopsy registration was transcribed from the published Supplementary Figure S1E before the project generated ECM, retention, resolver, repair, or locked-state scores. The registration table is preserved at `docs/methods_audit/machine_readable/UQ_Biopsy_Reconstruction_Map.tsv`. + +The archived filesystem timeline is consistent with that sequence: the component geometry output was completed at 19:54:16, the biopsy map at 20:04:22, and the module-score output began at 20:10:18 on 2026-07-11. These timestamps support temporal separation; they are not a substitute for a prospective blinding log. + +The source study's original per-spot `*_samples.csv` files are referenced by its public code but are absent from the local data archive. The original operator's strict score blinding was not documented. Therefore the historical record supports temporal separation from score generation, while it does not prove strict operator blinding. + +## Stress tests + +The mapping sensitivity analysis reruns spatial topology after: + +1. removing all nearest-component fragment rescues; +2. splitting every geometric component into an independent analysis unit; +3. combining component splitting with fragment removal; +4. excluding the inferred synchronous pair; +5. excluding every biopsy assembled from multiple components; and +6. leaving out each Visium array in turn. + +The largest retention-domain effect and interface-compression effect retained their expected directions in all 12 scenario-metric tests and all 16 leave-one-array-out tests. Full estimates are in `results/S15_UQ_biopsy_mapping_sensitivity/`. + +## Manuscript wording + +Use the following wording: + +> Biopsy fields were registered from the published spatial layout before module-score generation. We independently reconstructed hex-grid components using array coordinates alone and verified 100% agreement among directly connected spots. Mapping sensitivity analyses that removed rescued fragments, split geometric components, excluded inferred or merged fields, and left out each array preserved both retention-domain expansion and interface compression. Strict blinding of the historical registration operator was not documented. diff --git a/docs/methods_audit/UQ_Reconstruction_Audit.xlsx b/docs/methods_audit/UQ_Reconstruction_Audit.xlsx new file mode 100644 index 0000000..34112ea Binary files /dev/null and b/docs/methods_audit/UQ_Reconstruction_Audit.xlsx differ diff --git a/docs/methods_audit/machine_readable/Analysis_Timeline.tsv b/docs/methods_audit/machine_readable/Analysis_Timeline.tsv new file mode 100644 index 0000000..fd9b3d8 --- /dev/null +++ b/docs/methods_audit/machine_readable/Analysis_Timeline.tsv @@ -0,0 +1,18 @@ +date_time item classification evidence already_seen not_yet_analyzed source +2026-07-11 v16 scientific outline data-driven refinement Five scientific spines; explicit evolution after staged analyses Multiple public and clinical analyses Not fully reconstructable archived v16 scientific outline (v16_科学总纲.md) +2026-07-11 19:54 UQ connected-component geometry planned reconstruction Pure coordinate-based component outputs created Visium positions and published source material UQ ECM/retention/resolver scores not yet generated in this run UQ_Visium_component_summary.tsv file timestamp +2026-07-11 20:04 UQ 33-biopsy curated map data-driven reconstruction Mapping table timestamp; Figure S1E registration Component geometry and published layout/stage colors Module score output timestamp 20:15 UQ_Visium_curated_biopsy_map.tsv +2026-07-11 20:15 UQ ECM/retention/resolver scoring planned analysis after reconstruction Spot score and trend output timestamps Curated biopsy map Later basin/topology refinements UQ_Visium_spot_module_scores.parquet +2026-07-12 10:30 Three linked predictions frozen v16 questions Working draft explicitly says three linked predictions GSE295293, GSE305331, UQ and LINCS analyses substantially complete Later basin/topology and final sequence synthesis v16_Main_Manuscript_Working_Draft_EN.md:15 +2026-07-12 10:39 v16 task checklist analysis chronology Lists GSE306327, UQ, LINCS scoring and ordered-pair hypothesis as completed Core results Cannot establish from checklist v16_执行任务清单.md:48-70,102-110 +2026-07-12 15:38 Sequential pair scoring script post-hoc exploratory Script filesystem timestamp; primary and 27 sensitivity weights encoded Name-collapsed compound scores and selected focus compounds No record proving weights fixed before observing ezetimibe/verteporfin sequential_basin_switch_drugs.py +2026-07-12 16:07 Four linked predictions final narrative organization Earliest located exact four-prediction formulation Core spatial and sequence results Prospective wet-lab equal-exposure experiment Final_Main_Manuscript_EN.md:23 +First located 2026-07-11 Scar top-15% threshold analysis rule; prespecification unproven Encoded in GSE306327 and UQ scripts; 10/15/20% later sensitivity Spatial datasets No earlier protocol located GSE306327_reaction_front_spatial.py; UQ_Visium_resolver_window_analysis.py +First located 2026-07-12 State posterior 0.50; 0.40/0.60/0.67 sensitivity data-driven refinement / planned sensitivity unproven Encoded in spatial-domain analysis and manuscript methods UQ basin results No pre-analysis freeze located spatial_domain_wall_resolver_window.py; Main_Manuscript_SpatialOccupation_Final.md:294-296 +Documented by 2026-07-11 Clinical CAP 280 / LSM 9.5 thresholds prespecified within v16 clinical stage Stage-01 report labels four states and pre-specified history model Institutional cohort Predates final RW framing, not data-independent preregistration 阶段01_启动与临床路径审计_20260711.md:40-43,96 +Later manuscript/sensitivity stage LSM 12.5 kPa planned sensitivity / clinical reference Higher-threshold sensitivity stratum in final methods Clinical distributions No independent timestamped freeze located Main_Manuscript_SpatialOccupation_Final.md:206 +Later manuscript stage CAP decline 20 dB/m and relative LSM decline 20% operational definitions; a-priori wording unsupported by independent freeze Final manuscript definitions; 20% LSM informed by Baveno VII Longitudinal cohort No dated protocol located Main_Manuscript_SpatialOccupation_Final.md:66,210 +2026-07-12 mechanism expansion Clearance-inefficiency score post-hoc exploratory Explicitly treated as post-hoc in manuscript history; generated in S10 UQ module scores No prospective freeze S10_UQ_spatial_proteolytic_lock +By 2026-07-12 10:39 JB321/JB337 label conflict data-quality sensitivity Processed metadata and pathology supplement disagreed; both label assignments analyzed GSE244832 metadata and supplement Original author adjudication unavailable v16_执行任务清单.md:59; final Methods +Not documented Module gene-list freeze data-driven refinement Lists are encoded in dated scripts, but no independent freeze artifact was found Relevant datasets Cannot establish Dataset-specific scripts +Not documented Ezetimibe-verteporfin before/after rule freeze post-hoc mechanism-anchored nomination FOCUS list and scoring rules coexist in same script; no earlier immutable rule file Compound-level scores and biological identities Prospective wet-lab order test sequential_basin_switch_drugs.py diff --git a/docs/methods_audit/machine_readable/Drug_Order_27Weight_AllPairs.tsv.gz b/docs/methods_audit/machine_readable/Drug_Order_27Weight_AllPairs.tsv.gz new file mode 100644 index 0000000..354e228 Binary files /dev/null and b/docs/methods_audit/machine_readable/Drug_Order_27Weight_AllPairs.tsv.gz differ diff --git a/docs/methods_audit/machine_readable/Drug_Order_Complete_Results.tsv b/docs/methods_audit/machine_readable/Drug_Order_Complete_Results.tsv new file mode 100644 index 0000000..26984ca --- /dev/null +++ b/docs/methods_audit/machine_readable/Drug_Order_Complete_Results.tsv @@ -0,0 +1,300 @@ +early_compound late_compound forward_score reverse_score order_advantage early_mean_resolver early_resolver_floor early_retention late_retention late_q25_retention late_resolver_floor early_tier late_tier both_named both_hard_gate forward_percentile order_percentile basin_switch_index basin_switch_rank early_score late_score eligibility_notes rank_min_27_weights rank_max_27_weights +ezetimibe aliskiren 0.991250659782617 0.4635385405493989 0.527712119233218 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9832775919732442 0.9832775919732442 0.9832775919732442 1 4.033512798365034 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 1 3 +ezetimibe prednisone 0.9586663077888448 0.4112435656318824 0.5474227421569623 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9732441471571908 0.9966555183946488 0.981438127090301 2 4.033512798365034 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 2 4 +r(-)-propylnorapomorphine aliskiren 0.9556010816660192 0.421358848153244 0.5342422335127752 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9698996655518396 0.9899665551839464 0.976923076923077 3 3.7567379308635473 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 2 7 +panobinostat prednisone 0.9964218039826918 0.5280599711566335 0.4683618328260582 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.9866220735785952 0.939799331103679 0.9702341137123748 4 4.2164036292646205 4.488126371972259 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 1 11 +panobinostat aliskiren 1.029006155976464 0.58035494607415 0.4486512099023141 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.9966555183946488 0.9163879598662208 0.968561872909699 5 4.2164036292646205 4.2775155343430695 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 1 8 +r(-)-propylnorapomorphine prednisone 0.9230167296722472 0.3690638732357275 0.5539528564365196 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.94314381270903 1.0 0.9630434782608696 6 3.7567379308635473 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 3 13 +ezetimibe psb-069 1.0094935946935226 0.5710814891102176 0.438412105583305 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.9933110367892976 0.8996655518394648 0.960535117056856 7 4.033512798365034 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 5 11 +r(-)-propylnorapomorphine psb-069 0.9738440165769248 0.5289017967140627 0.4449422198628622 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.979933110367893 0.9096989966555185 0.9553511705685618 8 3.7567379308635473 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 5 16 +stk-249718 aliskiren 0.9182493440836432 0.3976146722404612 0.520634671843182 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9364548494983278 0.979933110367893 0.9516722408026757 9 3.74280352389874 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 5 15 +ezetimibe bromocriptine 0.9102166814171516 0.4344725208643396 0.4757441605528121 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9331103678929766 0.9498327759197324 0.9389632107023412 10 4.033512798365034 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 8 20 +stk-249718 psb-069 0.9364922789945488 0.5051576208012799 0.431334658193269 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.9565217391304348 0.8896321070234113 0.9331103678929766 11 3.74280352389874 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 10 24 +ezetimibe pd-0325901 0.9036995703834922 0.4199196235350673 0.4837799468484249 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.9163879598662208 0.9632107023411371 0.9327759197324414 12 4.033512798365034 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 10 18 +stk-249718 prednisone 0.8856649920898712 0.3453196973229447 0.5403452947669264 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8929765886287625 0.9933110367892976 0.9280936454849498 13 3.74280352389874 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 9 21 +thiostrepton aliskiren 0.8916110471186658 0.3982615905207776 0.4933494565978882 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.8996655518394648 0.9698996655518396 0.924247491638796 14 3.8549695031365783 4.2775155343430695 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 10 22 +panobinostat pd-0325901 0.9414550665773392 0.5367360290598184 0.4047190375175208 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.959866220735786 0.8528428093645485 0.9224080267558528 15 4.2164036292646205 3.271975325148467 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 7 25 +panobinostat bromocriptine 0.9479721776109988 0.5512889263890906 0.3966832512219082 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.9665551839464884 0.8361204013377926 0.9209030100334448 16 4.2164036292646205 3.597990883692539 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 8 26 +y-26763 prednisone 0.8770943327016003 0.3436154609339103 0.5334788717676899 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_3_computational_hit Tier_4_not_prioritized True False 0.8795986622073578 0.9866220735785952 0.9170568561872908 17 2.8736127698234353 4.488126371972259 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 8 22 +y-26763 aliskiren 0.9096786846953724 0.4732260606547314 0.436452624040641 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_3_computational_hit Tier_4_not_prioritized True False 0.9264214046822744 0.8929765886287625 0.9147157190635452 18 2.8736127698234353 4.2775155343430695 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 10 26 +panobinostat psb-069 1.0472490908873695 0.6878978946349686 0.3593511962524008 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True True 1.0 0.7290969899665551 0.9051839464882944 19 4.2164036292646205 4.200628672561935 early_tier=Excluded_safety; late_tier=Tier_3_computational_hit; both_hard_gate=True 12 22 +r(-)-propylnorapomorphine bromocriptine 0.874567103300554 0.3922928284681846 0.4822742748323693 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8729096989966555 0.959866220735786 0.9033444816053512 20 3.7567379308635473 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 14 35 +thiostrepton psb-069 0.9098539820295716 0.5058045390815962 0.4040494429479753 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True False 0.9297658862876256 0.842809364548495 0.8993311036789298 21 3.8549695031365783 4.200628672561935 early_tier=Excluded_safety; late_tier=Tier_3_computational_hit; both_hard_gate=False 17 30 +r(-)-propylnorapomorphine pd-0325901 0.8680499922668945 0.3777399311389124 0.4903100611279821 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.862876254180602 0.9665551839464884 0.8991638795986622 22 3.7567379308635473 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 15 33 +thiostrepton prednisone 0.8590266951248936 0.3459666156032611 0.5130600795216325 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.8528428093645485 0.9765886287625418 0.8961538461538461 23 3.8549695031365783 4.488126371972259 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 15 27 +ezetimibe verteporfin 0.8923123237262998 0.5041988742064742 0.3881134495198255 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.9063545150501672 0.8093645484949833 0.8724080267558529 24 4.033512798365034 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 20 46 +ezetimibe wz-4002 0.9652742582820504 0.6285826451152504 0.3366916131667999 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.9765886287625418 0.6688963210702341 0.8688963210702341 25 4.033512798365034 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 24 36 +stk-249718 bromocriptine 0.837215365718178 0.3685486525554018 0.4686667131627761 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8193979933110368 0.94314381270903 0.8627090301003344 26 3.74280352389874 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 20 53 +y-26763 psb-069 0.927921619606278 0.5807690092155502 0.3471526103907278 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_3_computational_hit Tier_3_computational_hit True True 0.9464882943143812 0.6989966555183946 0.8598662207357859 27 2.8736127698234353 4.200628672561935 early_tier=Tier_3_computational_hit; late_tier=Tier_3_computational_hit; both_hard_gate=True 23 38 +stk-249718 pd-0325901 0.8306982546845185 0.3539957552261296 0.4767024994583889 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8060200668896321 0.9565217391304348 0.8586956521739131 28 3.74280352389874 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 23 52 +r(-)-propylnorapomorphine wz-4002 0.9296246801654529 0.5864029527190955 0.3432217274463572 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.9498327759197324 0.6822742474916388 0.8561872909698997 29 3.7567379308635473 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 25 49 +aminopentamide aliskiren 0.833238133998026 0.3769485101709882 0.4562896238270378 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8160535117056856 0.9264214046822744 0.8546822742474917 30 3.2496369333869217 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 20 57 +ezetimibe nvp-tae684 0.9061188932826064 0.5477355869546059 0.3583833063280004 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.919732441471572 0.725752508361204 0.8518394648829433 31 4.033512798365034 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 24 47 +pre-084 prednisone 0.8450637823672935 0.4211918654304647 0.4238719169368288 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.8294314381270903 0.882943143812709 0.8481605351170568 32 2.526038259615349 4.488126371972259 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 12 57 +r(-)-propylnorapomorphine verteporfin 0.856662745609702 0.4620191818103194 0.3946435637993826 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.8494983277591973 0.8294314381270903 0.8424749163879599 33 3.7567379308635473 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 27 69 +panobinostat verteporfin 0.9300678199201468 0.6210152797312254 0.3090525401889215 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True True 0.9531772575250836 0.6020066889632107 0.8302675585284282 34 4.2164036292646205 2.937649773036116 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 23 56 +pre-084 aliskiren 0.8776481343610656 0.5214680867225286 0.3561800476385369 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.882943143812709 0.7224080267558528 0.8267558528428094 35 2.526038259615349 4.2775155343430695 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 21 56 +r(-)-propylnorapomorphine nvp-tae684 0.8704693151660086 0.505555894558451 0.3649134206075576 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8695652173913043 0.7424749163879598 0.8250836120401337 36 3.7567379308635473 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 31 73 +stk-249718 wz-4002 0.8922729425830767 0.5626587768063127 0.3296141657767639 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.903010033444816 0.6521739130434783 0.8152173913043478 37 3.74280352389874 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 34 77 +thiostrepton bromocriptine 0.8105770687532006 0.3691955708357181 0.4413814979174824 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.7625418060200669 0.903010033444816 0.811705685618729 38 3.8549695031365783 3.597990883692539 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 33 62 +prochlorperazine aliskiren 0.8278346426991953 0.4319884201792616 0.3958462225199337 0.3393047527809228 0.148764285658087 0.0186749911970562 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.7959866220735786 0.8327759197324415 0.8088628762541805 39 2.4835161945213544 4.2775155343430695 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 28 68 +aminopentamide psb-069 0.8514810689089316 0.4844914587318069 0.3669896101771246 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.8361204013377926 0.745819397993311 0.804515050167224 40 3.2496369333869217 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 31 61 +aminopentamide prednisone 0.8006537820042539 0.3246535352534718 0.476000246750782 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.7224080267558528 0.9531772575250836 0.8031772575250836 41 3.2496369333869217 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 25 64 +thiostrepton pd-0325901 0.8040599577195411 0.3546426735064459 0.4494172842130951 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.7391304347826086 0.919732441471572 0.8023411371237459 42 3.8549695031365783 3.271975325148467 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 34 67 +panobinostat nvp-tae684 0.9438743894764532 0.664551992479357 0.2793223969970962 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.9632107023411371 0.5016722408026756 0.8016722408026756 43 4.2164036292646205 2.7994032456748315 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 28 64 +y-26763 pd-0325901 0.8221275952962478 0.4296071436403998 0.3925204516558479 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_3_computational_hit Tier_4_not_prioritized True False 0.7892976588628763 0.822742474916388 0.8010033444816054 44 2.8736127698234353 3.271975325148467 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 44 51 +y-26763 bromocriptine 0.8286447063299074 0.444160040969672 0.3844846653602353 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_3_computational_hit Tier_4_not_prioritized True False 0.7993311036789298 0.802675585284281 0.8005016722408027 45 2.8736127698234353 3.597990883692539 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 40 49 +panobinostat wz-4002 1.0030297544758977 0.7453990506400014 0.257630703835896 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True True 0.9899665551839464 0.4381270903010033 0.7968227424749165 46 4.2164036292646205 3.018593789307171 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 36 55 +loperamide prednisone 0.8322542188947812 0.4556978701776454 0.3765563487171358 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8093645484949833 0.7692307692307693 0.7953177257525084 47 2.0592202618733775 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 5 97 +panobinostat glycocholic-acid 0.8301217698654721 0.4582515775063445 0.3718701923591276 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.802675585284281 0.7591973244147158 0.7874581939799331 48 4.2164036292646205 2.5581223219077263 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 25 82 +stk-249718 verteporfin 0.819311008027326 0.4382750058975366 0.3810360021297894 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.782608695652174 0.7859531772575251 0.7837792642140469 49 3.74280352389874 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 37 96 +prochlorperazine prednisone 0.7952502907054231 0.3499372028523966 0.4453130878530265 0.3393047527809228 0.148764285658087 0.0186749911970562 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.7123745819397993 0.9130434782608696 0.7826086956521738 50 2.4835161945213544 4.488126371972259 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 27 69 +stk-249718 nvp-tae684 0.8331175775836326 0.4818117186456682 0.3513058589379643 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8127090301003345 0.7123745819397993 0.7775919732441472 51 3.74280352389874 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 41 103 +ezetimibe glycocholic-acid 0.7923662736716252 0.3414351719815934 0.4509311016900317 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6989966555183946 0.9230769230769232 0.7774247491638796 52 4.033512798365034 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 34 80 +geldanamycin aliskiren 0.9008760851704412 0.6279409286226072 0.272935156547834 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Excluded_safety Tier_4_not_prioritized True False 0.9130434782608696 0.4916387959866221 0.7655518394648829 53 2.176621694134193 4.2775155343430695 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 29 88 +ag-490 aliskiren 0.7893444688931581 0.3527509146517823 0.4365935542413758 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6889632107023411 0.8963210702341137 0.7615384615384615 54 2.6682951078262267 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 32 88 +panobinostat pd-184352 0.8064069023304101 0.422056929304427 0.384349973025983 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.7424749163879598 0.7959866220735786 0.7612040133779264 55 4.2164036292646205 2.782548756150072 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 29 99 +thiostrepton wz-4002 0.8656346456180992 0.5633056950866291 0.3023289505314701 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True False 0.8595317725752508 0.5652173913043478 0.7565217391304347 56 3.8549695031365783 3.018593789307171 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 47 89 +pre-084 psb-069 0.8958910692719713 0.6290110352833473 0.2668800339886239 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_1_mechanistic_probe Tier_3_computational_hit True True 0.9096989966555185 0.4615384615384615 0.7528428093645485 57 2.526038259615349 4.200628672561935 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_3_computational_hit; both_hard_gate=True 44 75 +geldanamycin prednisone 0.8682917331766691 0.5714705826803331 0.2968211504963359 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.4679000046518113 0.368160122902029 -0.106774996034801 Excluded_safety Tier_4_not_prioritized True False 0.8662207357859532 0.5418060200668896 0.7526755852842809 58 2.176621694134193 4.488126371972259 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 24 95 +prochlorperazine psb-069 0.8460775776101009 0.5395313687400802 0.3065462088700207 0.3393047527809228 0.148764285658087 0.0186749911970562 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True True 0.8327759197324415 0.5886287625418061 0.7473244147157191 59 2.4835161945213544 4.200628672561935 early_tier=Excluded_safety; late_tier=Tier_3_computational_hit; both_hard_gate=True 48 81 +ezetimibe pd-184352 0.768651406136563 0.305240523779676 0.463410882356887 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6454849498327759 0.9364548494983278 0.7473244147157191 59 4.033512798365034 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 41 86 +r(-)-propylnorapomorphine glycocholic-acid 0.7567166955550275 0.2577928971824429 0.4989237983725845 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6187290969899666 0.9732441471571908 0.742809364548495 61 3.7567379308635473 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 40 100 +ag-490 psb-069 0.8075874038040638 0.4602938632126011 0.3472935405914627 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.7591973244147158 0.7023411371237458 0.7392976588628762 62 2.6682951078262267 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 44 100 +loperamide aliskiren 0.8648385708885533 0.5866812091054661 0.2781573617830872 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.8561872909698997 0.4983277591973244 0.7309364548494983 63 2.0592202618733775 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 30 96 +ag-490 prednisone 0.7567601168993859 0.3004559397342659 0.45630417716512 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6220735785953178 0.9297658862876256 0.7297658862876255 64 2.6682951078262267 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 40 98 +y-26763 wz-4002 0.883702283194806 0.6382701652205829 0.2454321179742231 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_3_computational_hit Tier_1_mechanistic_probe True True 0.8896321070234113 0.4046822742474916 0.7198996655518395 65 2.8736127698234353 3.018593789307171 early_tier=Tier_3_computational_hit; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 65 82 +thiostrepton verteporfin 0.7926727110623486 0.438921924177853 0.3537507868844955 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True False 0.705685618729097 0.7190635451505016 0.7103678929765886 66 3.8549695031365783 2.937649773036116 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 53 116 +ezetimibe tyrphostin-1 0.817842282310483 0.5113162649573668 0.3065260173531161 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.7759197324414716 0.5852842809364549 0.7091973244147158 67 4.033512798365034 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 48 137 +thiostrepton nvp-tae684 0.8064792806186551 0.4824586369259845 0.3240206436926706 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.745819397993311 0.6287625418060201 0.7048494983277591 68 3.8549695031365783 2.7994032456748315 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 56 118 +geldanamycin psb-069 0.9191190200813468 0.7354838771834258 0.183635142897921 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.4291111048724916 0.3565118457966794 0.0297714109931673 Excluded_safety Tier_3_computational_hit True False 0.939799331103679 0.2274247491638795 0.6904682274247492 69 2.176621694134193 4.200628672561935 early_tier=Excluded_safety; late_tier=Tier_3_computational_hit; both_hard_gate=False 60 103 +r(-)-propylnorapomorphine pd-184352 0.7330018280199655 0.2630608313835211 0.4699409966364444 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5518394648829431 0.9464882943143812 0.6899665551839465 70 3.7567379308635473 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 49 117 +aminopentamide bromocriptine 0.7522041556325608 0.3478824904859288 0.404321665146632 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6053511705685619 0.8461538461538461 0.6896321070234115 71 3.2496369333869217 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 58 99 +arcyriaflavin-a prednisone 0.7864104255494321 0.4356065589698059 0.3508038665796262 0.2513968291958527 0.135857936926186 0.176811108055214 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6789297658862876 0.7090301003344481 0.6894648829431438 72 1.9248851248778247 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 19 126 +y-26763 verteporfin 0.8107403486390554 0.5138863943118069 0.2968539543272485 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_3_computational_hit Tier_1_mechanistic_probe True True 0.7658862876254181 0.5451505016722408 0.688628762541806 73 2.8736127698234353 2.937649773036116 early_tier=Tier_3_computational_hit; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 73 94 +aminopentamide pd-0325901 0.7456870445989013 0.3333295931566566 0.4123574514422446 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5919732441471572 0.8662207357859532 0.6879598662207358 74 3.2496369333869217 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 59 102 +y-26763 nvp-tae684 0.8245469181953617 0.5574231070599385 0.2671238111354233 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_3_computational_hit Tier_4_not_prioritized True False 0.7926421404682275 0.4648829431438127 0.6779264214046823 75 2.8736127698234353 2.7994032456748315 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 74 106 +arcyriaflavin-a aliskiren 0.8189947775432042 0.5461705752448843 0.2728242022983198 0.2513968291958527 0.135857936926186 0.176811108055214 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.7792642140468228 0.4882943143812709 0.6774247491638796 76 1.9248851248778247 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 40 120 +panobinostat tyrphostin-1 0.85559777850433 0.628132670482118 0.2274651080222121 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True True 0.8461538461538461 0.3612040133779264 0.6764214046822743 77 4.2164036292646205 2.207292994011233 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 47 126 +wz-4002 aliskiren 0.8878975514773398 0.6968770454109218 0.191020506066418 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.8963210702341137 0.2541806020066889 0.671571906354515 78 1.9599890247309877 4.2775155343430695 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 50 140 +ezetimibe duloxetine 0.7540904474426208 0.3761590098969579 0.3779314375456629 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6120401337792643 0.7759197324414716 0.6693979933110368 79 4.033512798365034 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 56 133 +pre-084 bromocriptine 0.7966141559956004 0.4924020670374693 0.304212088958131 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7157190635451505 0.5752508361204013 0.6665551839464883 80 2.526038259615349 3.597990883692539 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 64 107 +ezetimibe ambroxol 0.7397342591531693 0.3418128165741643 0.3979214425790049 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5719063545150501 0.8394648829431438 0.6655518394648829 81 4.033512798365034 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 58 136 +loperamide psb-069 0.8830815057994591 0.6942241576662849 0.1888573481331742 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.8862876254180602 0.2474916387959866 0.6627090301003344 82 2.0592202618733775 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 65 114 +pre-084 pd-0325901 0.7900970449619409 0.4778491697081971 0.3122478752537438 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.6923076923076923 0.6053511705685619 0.6618729096989967 83 2.526038259615349 3.271975325148467 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 57 106 +wz-4002 prednisone 0.8553131994835677 0.6445820704934054 0.2107311289901622 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.842809364548495 0.3110367892976589 0.6566889632107024 84 1.9599890247309877 4.488126371972259 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 43 152 +stk-249718 glycocholic-acid 0.7193649579726514 0.2755113036726557 0.4438536542999957 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5217391304347826 0.9063545150501672 0.6563545150501672 85 3.74280352389874 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 68 128 +ticlopidine aliskiren 0.7414480896910565 0.3614093916479587 0.3800386980430977 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5819397993311036 0.782608695652174 0.6521739130434783 86 2.009007845147325 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 50 131 +bibx-1382 aliskiren 0.7831141429820231 0.4674719324601547 0.3156422105218683 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6722408026755853 0.6120401337792643 0.6511705685618729 87 2.15358517128177 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 55 120 +ezetimibe tubocurarine 0.7220422201789916 0.3065483757028622 0.4154938444761293 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5317725752508361 0.8729096989966555 0.6511705685618729 87 4.033512798365034 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 65 139 +aminopentamide wz-4002 0.8072617324974596 0.5419926147368397 0.2652691177606199 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.7558528428093646 0.4548494983277591 0.6505016722408027 89 3.2496369333869217 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 68 146 +r(-)-propylnorapomorphine tyrphostin-1 0.7821927041938853 0.4691365725612119 0.3130561316326734 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6688963210702341 0.6086956521739131 0.6478260869565218 90 3.7567379308635473 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 61 154 +panobinostat duloxetine 0.7918459436364678 0.4929754154217088 0.2988705282147589 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.6956521739130435 0.5551839464882943 0.6464882943143813 91 4.2164036292646205 2.1732541979990767 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 41 150 +panobinostat ambroxol 0.7774897553470163 0.4586292220989153 0.3188605332481009 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.6588628762541806 0.6220735785953178 0.6459866220735786 92 4.2164036292646205 2.4175703242393984 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 49 148 +panobinostat tubocurarine 0.7597977163728387 0.4233647812276132 0.3364329351452254 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.6321070234113713 0.6655518394648829 0.6438127090301003 93 4.2164036292646205 2.099352326781365 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 58 157 +ezetimibe atorvastatin 0.7381697335383957 0.3611505521712677 0.377019181367128 0.5361593619787267 0.2945428660937718 -0.0482021930317084 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.568561872909699 0.7725752508361204 0.6399665551839464 94 4.033512798365034 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 65 146 +ticlopidine prednisone 0.7088637376972843 0.2961581635939341 0.4127055741033502 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5016722408026756 0.8695652173913043 0.6304347826086956 95 2.009007845147325 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 64 145 +geldanamycin bromocriptine 0.819842106804976 0.5988749089375478 0.2209671978674282 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.7859531772575251 0.3411371237458194 0.6302675585284281 96 2.176621694134193 3.597990883692539 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 59 141 +geldanamycin pd-0325901 0.8133249957713166 0.5843220116082757 0.2290029841630408 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.7692307692307693 0.3678929765886287 0.6287625418060201 97 2.176621694134193 3.271975325148467 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 60 142 +prochlorperazine bromocriptine 0.7468006643337302 0.4029224004942022 0.3438782638395279 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Excluded_safety Tier_4_not_prioritized True False 0.5953177257525084 0.6889632107023411 0.6280936454849498 98 2.4835161945213544 3.597990883692539 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 87 105 +wz-4002 psb-069 0.9061404863882454 0.8044199939717405 0.1017204924165049 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_1_mechanistic_probe Tier_3_computational_hit True True 0.9230769230769232 0.0702341137123745 0.6245819397993312 99 1.9599890247309877 4.200628672561935 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_3_computational_hit; both_hard_gate=True 77 144 +prochlorperazine pd-0325901 0.7402835533000706 0.3883695031649299 0.3519140501351406 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Excluded_safety Tier_4_not_prioritized True False 0.5752508361204013 0.7157190635451505 0.6244147157190636 100 2.4835161945213544 3.271975325148467 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 88 109 +stk-249718 pd-184352 0.6956500904375894 0.2393166554707383 0.456333434966851 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4548494983277591 0.9331103678929766 0.6222408026755852 101 3.74280352389874 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 76 143 +bibx-1382 prednisone 0.750529790988251 0.4151769575426383 0.3353528334456127 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6020066889632107 0.6588628762541806 0.6219063545150502 102 2.15358517128177 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 56 130 +panobinostat atorvastatin 0.7759252297322429 0.4779669576960186 0.2979582720362242 0.5086224198873555 0.4303749033382961 0.0823826835387283 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.6521739130434783 0.5518394648829431 0.6170568561872909 103 4.2164036292646205 2.075961514835675 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 54 163 +r(-)-propylnorapomorphine duloxetine 0.7184408693260231 0.3339793175008029 0.3844615518252202 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5183946488294314 0.7993311036789298 0.6167224080267558 104 3.7567379308635473 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 71 159 +pre-084 wz-4002 0.851671732860499 0.6865121912883801 0.1651595415721188 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.8394648829431438 0.1939799331103679 0.6135451505016724 105 2.526038259615349 3.018593789307171 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 98 111 +arcyriaflavin-a psb-069 0.8372377124541097 0.653713523805703 0.1835241886484067 0.2513968291958527 0.135857936926186 0.176811108055214 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.822742474916388 0.2240802675585284 0.6132107023411372 106 1.9248851248778247 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 80 132 +r(-)-propylnorapomorphine ambroxol 0.7040846810365716 0.2996331241780093 0.4044515568585622 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4849498327759197 0.8494983277591973 0.6125418060200669 107 3.7567379308635473 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 73 162 +ag-490 bromocriptine 0.7083104905276929 0.323684894966723 0.3846255955609698 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4983277591973244 0.8060200668896321 0.6060200668896321 108 2.6682951078262267 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 81 140 +prednisolone-acetate aliskiren 0.7539784021986028 0.4453582248672665 0.3086201773313362 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6086956521739131 0.5986622073578596 0.6051839464882944 109 1.8216565241617504 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 70 139 +thiostrepton glycocholic-acid 0.692726661007674 0.276158221952972 0.4165684390547019 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.4481605351170568 0.8762541806020067 0.5979933110367892 110 3.8549695031365783 2.5581223219077263 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 86 146 +ticlopidine psb-069 0.7596910246019621 0.4689523402087774 0.2907386843931847 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.6287625418060201 0.5317725752508361 0.5948160535117057 111 2.009007845147325 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 70 158 +bibx-1382 psb-069 0.8013570778929286 0.5750148810209734 0.2263421968719552 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.725752508361204 0.3511705685618729 0.5946488294314382 112 2.15358517128177 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 88 140 +ag-490 pd-0325901 0.7017933794940333 0.3091319976374507 0.3926613818565826 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4682274247491639 0.8260869565217391 0.5934782608695652 113 2.6682951078262267 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 85 146 +etomidate aliskiren 0.7889657141455996 0.5403857108368169 0.2485800033087827 0.2152146542710917 0.1923187635838985 0.189117331109527 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.68561872909699 0.4180602006688963 0.5919732441471571 114 1.8530080550657204 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 63 160 +r(-)-propylnorapomorphine atorvastatin 0.7025201554217981 0.3189708597751127 0.3835492956466854 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4782608695652174 0.7926421404682275 0.5882943143812709 115 3.7567379308635473 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 78 172 +geldanamycin wz-4002 0.8748996836698747 0.7929850331884587 0.081914650481416 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True False 0.8762541806020067 0.0501672240802675 0.5871237458193981 116 2.176621694134193 3.018593789307171 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 87 142 +y-26763 glycocholic-acid 0.7107942985843807 0.351122692086926 0.3596716064974546 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_3_computational_hit Tier_4_not_prioritized True False 0.5050167224080268 0.7324414715719063 0.5846153846153845 117 2.8736127698234353 2.5581223219077263 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 100 134 +nu-7026 prednisone 0.6899139605913429 0.2794711267989541 0.4104428337923888 0.2296837022128914 0.121435706104551 0.0272444321049584 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4347826086956521 0.862876254180602 0.5846153846153845 117 1.7581600552143564 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 66 167 +r(-)-propylnorapomorphine tubocurarine 0.6863926420623938 0.2643686833067073 0.4220239587556865 0.5167463860873664 0.2317333327872412 -0.0806753974821832 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4247491638795986 0.8795986622073578 0.5839464882943144 119 3.7567379308635473 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 80 167 +nu-7026 aliskiren 0.722498312585115 0.3857473358031481 0.3367509767819669 0.2296837022128914 0.121435706104551 0.0272444321049584 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5351170568561873 0.6722408026755853 0.5831103678929765 120 1.7581600552143564 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 67 168 +aminopentamide verteporfin 0.734299797941709 0.4176088438280637 0.3166909541136453 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5585284280936454 0.6187290969899666 0.5795986622073579 121 3.2496369333869217 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 91 156 +etomidate prednisone 0.7563813621518275 0.4721673145550227 0.2842140475968047 0.2152146542710917 0.1923187635838985 0.189117331109527 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6153846153846154 0.5117056856187291 0.5790969899665552 122 1.8530080550657204 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 51 165 +stk-249718 tyrphostin-1 0.7448409666115092 0.4453923966484291 0.29944856996308 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5886287625418061 0.5585284280936454 0.5780936454849499 123 3.74280352389874 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 81 186 +prochlorperazine wz-4002 0.8018582411986288 0.597032524745113 0.2048257164535157 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3318178856538402 0.1799050901706019 0.1696766402040209 Excluded_safety Tier_1_mechanistic_probe True True 0.7290969899665551 0.2876254180602006 0.574581939799331 124 2.4835161945213544 3.018593789307171 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 108 148 +aminopentamide nvp-tae684 0.7481063674980153 0.4611455565761952 0.2869608109218201 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5986622073578596 0.5284280936454849 0.5740802675585285 125 3.2496369333869217 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 91 166 +prednisolone-acetate prednisone 0.7213940502048307 0.3930632499497501 0.3283308002550806 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5284280936454849 0.6488294314381271 0.5705685618729097 126 1.8216565241617504 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 79 151 +thiostrepton pd-184352 0.669011793472612 0.2399635737510546 0.4290482197215573 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.3979933110367893 0.8862876254180602 0.568896321070234 127 3.8549695031365783 2.782548756150072 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 99 158 +loperamide bromocriptine 0.7838045925230881 0.5576151894204067 0.2261894031026814 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6755852842809364 0.3478260869565217 0.5608695652173913 128 2.0592202618733775 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 72 157 +loperamide pd-0325901 0.7772874814894286 0.5430622920911345 0.234225189398294 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6555183946488294 0.3779264214046823 0.558361204013378 129 2.0592202618733775 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 71 161 +ag-490 wz-4002 0.7633680673925916 0.5177950192176338 0.2455730481749577 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6387959866220736 0.4080267558528428 0.5580267558528429 130 2.6682951078262267 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 94 179 +loperamide wz-4002 0.8388621693879869 0.7517253136713176 0.0871368557166692 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.8260869565217391 0.0535117056856187 0.555685618729097 131 2.0592202618733775 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 111 151 +etomidate psb-069 0.8072086490565051 0.6479286593976354 0.1592799896588697 0.2152146542710917 0.1923187635838985 0.189117331109527 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.7525083612040134 0.1806020066889632 0.5523411371237459 132 1.8530080550657204 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 97 163 +y-26763 pd-184352 0.6870794310493187 0.3149280438850086 0.37215138716431 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_3_computational_hit Tier_4_not_prioritized True False 0.4280936454849498 0.7625418060200669 0.5451505016722409 133 2.8736127698234353 2.782548756150072 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 112 148 +pre-084 verteporfin 0.7787097983047484 0.5621284203796042 0.2165813779251442 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.6622073578595318 0.3277591973244147 0.5451505016722408 134 2.526038259615349 2.937649773036116 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 119 140 +pre-084 nvp-tae684 0.792516367861055 0.6056651331277356 0.1868512347333193 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7023411371237458 0.2408026755852843 0.5408026755852843 135 2.526038259615349 2.7994032456748315 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 122 145 +stk-249718 ambroxol 0.6667329434541955 0.2758889482652266 0.3908439951889689 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.391304347826087 0.8160535117056856 0.5399665551839465 136 3.74280352389874 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 96 181 +prednisolone-acetate psb-069 0.7722213371095085 0.5529011734280853 0.2193201636814231 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.6488294314381271 0.3311036789297659 0.5376254180602007 137 1.8216565241617504 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 103 166 +wz-4002 bromocriptine 0.8068635731118745 0.6678110257258624 0.1390525473860121 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7491638795986622 0.1371237458193979 0.5349498327759197 138 1.9599890247309877 3.597990883692539 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 75 198 +stk-249718 duloxetine 0.6810891317436472 0.3102351415880201 0.370853990155627 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4147157190635451 0.7525083612040134 0.532943143812709 139 3.74280352389874 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 89 192 +geldanamycin nvp-tae684 0.8157443186704305 0.7121379750278143 0.1036063436426162 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.7725752508361204 0.0769230769230769 0.5290969899665553 140 2.176621694134193 2.7994032456748315 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 112 171 +emf-sumo1-10 aliskiren 0.6634220992407156 0.2738606472617932 0.3895614519789223 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.4764824906984965 0.2830468008501662 -0.0147318169474601 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3712374581939799 0.8127090301003345 0.525752508361204 141 1.8755526661235435 4.2775155343430695 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 76 202 +wz-4002 pd-0325901 0.8003464620782151 0.6532581283965901 0.147088333681625 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7190635451505016 0.1638795986622073 0.5247491638795986 142 1.9599890247309877 3.271975325148467 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 74 200 +nu-7026 psb-069 0.7407412474960207 0.4932902843639667 0.2474509631320539 0.2296837022128914 0.121435706104551 0.0272444321049584 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.5785953177257525 0.4147157190635451 0.5212374581939799 143 1.7581600552143564 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 100 186 +geldanamycin verteporfin 0.8019377491141241 0.6686012622796826 0.1333364868344414 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True False 0.7324414715719063 0.1237458193979933 0.5193979933110368 144 2.176621694134193 2.937649773036116 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 108 168 +stk-249718 tubocurarine 0.6490409044800178 0.2406245073939245 0.4084163970860933 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3277591973244147 0.8561872909698997 0.5127090301003344 145 3.74280352389874 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 108 186 +stk-249718 atorvastatin 0.6651684178394222 0.29522668386233 0.3699417339770922 0.4827735199193869 0.3056777156889438 -0.0874331403109762 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3779264214046823 0.7491638795986622 0.5078595317725753 146 3.74280352389874 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 104 199 +prochlorperazine nvp-tae684 0.7427028761991846 0.5161854665844685 0.2265174096147161 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3068421044283443 0.1615088503393862 0.1419794602053506 Excluded_safety Tier_4_not_prioritized True False 0.5852842809364549 0.3578595317725752 0.505685618729097 147 2.4835161945213544 2.7994032456748315 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 129 174 +prochlorperazine verteporfin 0.7288963066428782 0.472648753836337 0.2562475528065412 0.3393047527809228 0.148764285658087 0.0186749911970562 0.3174578201853567 0.1837441553879115 0.0395371671766042 Excluded_safety Tier_1_mechanistic_probe True True 0.5451505016722408 0.431438127090301 0.5053511705685618 148 2.4835161945213544 2.937649773036116 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 135 164 +thiostrepton tyrphostin-1 0.7182026696465318 0.4460393149287455 0.2721633547177863 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True False 0.5150501672240803 0.4816053511705686 0.5033444816053512 149 3.8549695031365783 2.207292994011233 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 104 214 +arcyriaflavin-a bromocriptine 0.7379607991777389 0.5171045555598249 0.220856243617914 0.2513968291958527 0.135857936926186 0.176811108055214 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5652173913043478 0.3377926421404682 0.4856187290969899 150 1.9248851248778247 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 104 181 +arcyriaflavin-a pd-0325901 0.7314436881440793 0.5025516582305528 0.2288920299135265 0.2513968291958527 0.135857936926186 0.176811108055214 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5484949832775919 0.3645484949832775 0.4841137123745819 151 1.9248851248778247 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 105 183 +ag-490 nvp-tae684 0.7042127023931474 0.4369479610569893 0.267264741336158 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4882943143812709 0.4682274247491639 0.4812709030100334 152 2.6682951078262267 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 120 206 +wz-4002 nvp-tae684 0.8027657849773292 0.7810740918161287 0.0216916931612004 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.7357859531772575 0.0066889632107023 0.4806020066889632 153 1.9599890247309877 2.7994032456748315 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 107 202 +ag-490 verteporfin 0.6904061328368409 0.3934112483088577 0.2969948845279831 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.4414715719063545 0.5484949832775919 0.4789297658862876 154 2.6682951078262267 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 122 191 +arcyriaflavin-a wz-4002 0.7930183760426377 0.7112146798107358 0.0818036962319018 0.2513968291958527 0.135857936926186 0.176811108055214 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.7090301003344481 0.0468227424749163 0.477257525083612 155 1.9248851248778247 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 134 170 +emf-sumo1-10 prednisone 0.6308377472469434 0.2215656723442767 0.4092720749026666 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.4679000046518113 0.368160122902029 -0.106774996034801 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2709030100334448 0.8595317725752508 0.4769230769230769 156 1.8755526661235435 4.488126371972259 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 96 211 +y-26763 tyrphostin-1 0.7362703072232386 0.5210037850626994 0.2152665221605392 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_3_computational_hit Tier_1_mechanistic_probe True True 0.5618729096989966 0.3177257525083612 0.4764214046822742 157 2.8736127698234353 2.207292994011233 early_tier=Tier_3_computational_hit; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 122 196 +emf-sumo1-10 psb-069 0.6816650341516213 0.3814035958226119 0.3002614383290093 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.4291111048724916 0.3565118457966794 0.0297714109931673 Tier_4_not_prioritized Tier_3_computational_hit True False 0.4180602006688963 0.5618729096989966 0.4683946488294314 158 1.8755526661235435 4.200628672561935 early_tier=Tier_4_not_prioritized; late_tier=Tier_3_computational_hit; both_hard_gate=False 97 236 +bibx-1382 bromocriptine 0.702080164616558 0.4384059127750954 0.2636742518414625 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4749163879598662 0.4481605351170568 0.4655518394648829 159 2.15358517128177 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 129 175 +ticlopidine bromocriptine 0.6604141113255912 0.3323433719628993 0.3280707393626919 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3678929765886287 0.6454849498327759 0.4650501672240802 160 2.009007845147325 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 121 192 +loperamide verteporfin 0.7659002348322361 0.6273415427625415 0.1385586920696946 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6421404682274248 0.1337792642140468 0.4642140468227425 161 2.0592202618733775 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 124 186 +thiostrepton duloxetine 0.6544508347786696 0.3108820598683365 0.3435687749103331 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.3444816053511705 0.68561872909699 0.4638795986622073 162 3.8549695031365783 2.1732541979990767 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 118 210 +y-26763 duloxetine 0.6725184723553764 0.3688142366322967 0.3037042357230797 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_3_computational_hit Tier_4_not_prioritized True False 0.4013377926421405 0.5719063545150501 0.4610367892976588 163 2.8736127698234353 2.1732541979990767 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 132 192 +bibx-1382 pd-0325901 0.6955630535828984 0.4238530154458232 0.2717100381370751 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.451505016722408 0.4782608695652174 0.4608695652173913 164 2.15358517128177 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 131 179 +loperamide nvp-tae684 0.7797068043885427 0.6708782555106731 0.1088285488778695 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.6655518394648829 0.0802675585284281 0.4607023411371237 165 2.0592202618733775 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 126 178 +thiostrepton ambroxol 0.6400946464892181 0.2765358665455429 0.3635587799436751 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.3010033444816054 0.7391304347826086 0.4543478260869564 166 3.8549695031365783 2.4175703242393984 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 121 207 +aminopentamide glycocholic-acid 0.6343537478870342 0.2548451416031828 0.3795086062838514 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2775919732441471 0.7792642140468228 0.4531772575250836 167 3.2496369333869217 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 134 187 +ticlopidine pd-0325901 0.6538970002919318 0.3177904746336271 0.3361065256583047 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3377926421404682 0.6622073578595318 0.4513377926421404 168 2.009007845147325 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 124 195 +wz-4002 verteporfin 0.7889592154210227 0.7375373790679973 0.0514218363530253 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.6822742474916388 0.020066889632107 0.4505016722408027 169 1.9599890247309877 2.937649773036116 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 110 210 +bibx-1382 wz-4002 0.7571377414814566 0.6325160370260062 0.1246217044554504 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6254180602006689 0.1103678929765886 0.4451505016722408 170 2.15358517128177 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 164 176 +pre-084 glycocholic-acid 0.6787637482500738 0.3993647181547232 0.2793990300953506 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.411371237458194 0.5050167224080268 0.4441471571906354 171 2.526038259615349 2.5581223219077263 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 145 191 +y-26763 ambroxol 0.6581622840659249 0.3515003366794968 0.306661947386428 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_3_computational_hit Tier_4_not_prioritized True False 0.3612040133779264 0.5919732441471572 0.4419732441471572 172 2.8736127698234353 2.4175703242393984 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 148 201 +thiostrepton tubocurarine 0.6224026075150404 0.2412714256742408 0.3811311818407995 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.2508361204013378 0.7892976588628763 0.4392976588628762 173 3.8549695031365783 2.099352326781365 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 125 209 +aminopentamide pd-184352 0.6106388803519722 0.2186504934012653 0.3919883869507068 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2274247491638795 0.8193979933110368 0.4346153846153846 174 3.2496369333869217 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 145 188 +thiostrepton atorvastatin 0.6385301208744447 0.2958736021426462 0.3426565187317985 0.4468245117792061 0.4335254803299904 -0.0688117179605695 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.2976588628762542 0.6789297658862876 0.4311036789297658 175 3.8549695031365783 2.075961514835675 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 130 219 +etomidate wz-4002 0.7629893126450331 0.7054298154026684 0.0575594972423647 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.6354515050167224 0.0334448160535117 0.4247491638795986 176 1.8530080550657204 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 147 201 +ticlopidine wz-4002 0.7154716881904899 0.5264534962138102 0.1890181919766796 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5117056856187291 0.2508361204013378 0.4204013377926421 177 2.009007845147325 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 153 216 +y-26763 tubocurarine 0.6404702450917472 0.3162358958081948 0.3242343492835524 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_3_computational_hit Tier_4_not_prioritized True False 0.3043478260869565 0.6321070234113713 0.4190635451505017 178 2.8736127698234353 2.099352326781365 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 154 201 +pre-084 pd-184352 0.6550488807150118 0.3631700699528057 0.291878810762206 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.3511705685618729 0.5351170568561873 0.4155518394648829 179 2.526038259615349 2.782548756150072 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 153 199 +etomidate bromocriptine 0.7079317357801345 0.5113196911517575 0.196612044628377 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4949832775919732 0.2675585284280936 0.4153846153846154 180 1.8530080550657204 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 123 211 +prednisolone-acetate bromocriptine 0.6729444238331376 0.4162922051822072 0.2566522186509303 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4046822742474916 0.4347826086956521 0.4152173913043478 181 1.8216565241617504 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 152 215 +y-26763 atorvastatin 0.6565977584511513 0.3708380722766002 0.2857596861745511 0.4209383817921791 0.1104624923318624 0.0190958171668979 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_3_computational_hit Tier_4_not_prioritized True False 0.3578595317725752 0.5183946488294314 0.4140468227424749 182 2.8736127698234353 2.075961514835675 early_tier=Tier_3_computational_hit; late_tier=Tier_4_not_prioritized; both_hard_gate=False 157 213 +prednisolone-acetate pd-0325901 0.666427312799478 0.4017393078529349 0.264688004946543 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3879598662207358 0.451505016722408 0.4102006688963211 183 1.8216565241617504 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 150 217 +etomidate pd-0325901 0.7014146247464749 0.4967667938224851 0.2046478309239897 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4648829431438127 0.2842809364548495 0.4016722408026756 184 1.8530080550657204 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 122 217 +geldanamycin glycocholic-acid 0.7019916990594495 0.5058375600548017 0.1961541390046477 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.471571906354515 0.2608695652173913 0.3978260869565217 185 2.176621694134193 2.5581223219077263 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 125 221 +ag-490 glycocholic-acid 0.5904600827821663 0.2194775648725531 0.3709825179096132 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2006688963210702 0.7558528428093646 0.3949832775919732 186 2.6682951078262267 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 164 215 +prochlorperazine glycocholic-acid 0.6289502565882035 0.3098850516114561 0.3190652049767474 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2927055549290445 0.113612961049916 -0.1485714369586535 Excluded_safety Tier_4_not_prioritized True False 0.2675585284280936 0.6254180602006689 0.3928093645484949 187 2.4835161945213544 2.5581223219077263 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 171 192 +arcyriaflavin-a nvp-tae684 0.7338630110431934 0.6303676216500913 0.1034953893931021 0.2513968291958527 0.135857936926186 0.176811108055214 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.5551839464882943 0.0735785953177257 0.3866220735785953 188 1.9248851248778247 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 165 207 +prednisolone-acetate wz-4002 0.7280020006980362 0.610402329433118 0.1175996712649182 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5418060200668896 0.0903010033444816 0.3837792642140468 189 1.8216565241617504 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 176 197 +arcyriaflavin-a verteporfin 0.7200564414868871 0.5868309089019599 0.1332255325849272 0.2513968291958527 0.135857936926186 0.176811108055214 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.5250836120401338 0.1204013377926421 0.3834448160535117 190 1.9248851248778247 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 160 208 +nu-7026 bromocriptine 0.6414643342196498 0.3566813161180887 0.2847830181015611 0.2296837022128914 0.121435706104551 0.0272444321049584 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3110367892976589 0.5150501672240803 0.3824414715719063 191 1.7581600552143564 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 153 231 +nu-7026 pd-0325901 0.6349472231859903 0.3421284187888164 0.2928188043971738 0.2296837022128914 0.121435706104551 0.0272444321049584 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2842809364548495 0.5384615384615384 0.3732441471571905 192 1.7581600552143564 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 158 224 +geldanamycin pd-184352 0.6782768315243874 0.4696429118528843 0.208633919671503 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.4080267558528428 0.3043478260869565 0.3717391304347826 193 2.176621694134193 2.782548756150072 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 138 234 +prochlorperazine pd-184352 0.6052353890531414 0.2736904034095387 0.3315449856436027 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Excluded_safety Tier_4_not_prioritized True False 0.217391304347826 0.6555183946488294 0.3707357859531772 194 2.4835161945213544 2.782548756150072 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 182 200 +aminopentamide tyrphostin-1 0.6598297565258922 0.4247262345789562 0.2351035219469359 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.3645484949832775 0.3812709030100334 0.3704013377926421 195 3.2496369333869217 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 154 253 +ag-490 pd-184352 0.5667452152471042 0.1944528978820595 0.3722923173650447 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1538461538461538 0.7658862876254181 0.3680602006688963 196 2.6682951078262267 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 173 229 +pre-084 tyrphostin-1 0.7042397568889316 0.5692458111304965 0.134993945758435 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.4916387959866221 0.1270903010033444 0.3640468227424749 197 2.526038259615349 2.207292994011233 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 172 222 +emf-sumo1-10 bromocriptine 0.5823881208752504 0.2447946275767338 0.3375934932985165 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.3878145326679159 0.2492790310126212 -0.0219900336648736 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1906354515050167 0.6755852842809364 0.3603678929765886 198 1.8755526661235435 3.597990883692539 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 143 255 +geldanamycin tyrphostin-1 0.7274677076983074 0.6757186530305752 0.0517490546677321 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True False 0.5384615384615384 0.0267558528428093 0.3593645484949832 199 2.176621694134193 2.207292994011233 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 168 231 +bibx-1382 nvp-tae684 0.6979823764820123 0.5516689788653617 0.1463133976166506 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4615384615384615 0.1538461538461538 0.3538461538461539 200 2.15358517128177 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 195 211 +emf-sumo1-10 pd-0325901 0.5758710098415908 0.2302417302474616 0.3456292795941291 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.3888269828425513 0.1429306140376461 -0.0338409654796123 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1672240802675585 0.6956521739130435 0.3521739130434782 201 1.8755526661235435 3.271975325148467 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 149 253 +nu-7026 wz-4002 0.6965219110845484 0.5507914403689995 0.1457304707155489 0.2296837022128914 0.121435706104551 0.0272444321049584 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.4581939799331103 0.1505016722408027 0.3505016722408027 202 1.7581600552143564 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 178 231 +bibx-1382 verteporfin 0.684175806925706 0.5081322661172302 0.1760435408084758 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.4214046822742475 0.217391304347826 0.35 203 2.15358517128177 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 190 219 +loperamide glycocholic-acid 0.6659541847775616 0.4645778405376606 0.201376344239901 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3846153846153846 0.2775919732441471 0.3471571906354515 204 2.0592202618733775 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 159 235 +aminopentamide ambroxol 0.5817217333685784 0.2552227861957536 0.3264989471728247 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1839464882943143 0.6421404682274248 0.3443143812709029 205 3.2496369333869217 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 172 239 +ticlopidine verteporfin 0.6425097536347393 0.4020697253050341 0.2404400283297051 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.3177257525083612 0.391304347826087 0.3434782608695652 206 2.009007845147325 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 182 243 +aminopentamide duloxetine 0.59607792165803 0.2895689795185471 0.3065089421394828 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2107023411371237 0.5819397993311036 0.3406354515050167 207 3.2496369333869217 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 168 242 +ticlopidine nvp-tae684 0.6563163231910458 0.4456064380531657 0.21070988513788 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.354515050167224 0.3076923076923077 0.3381270903010033 208 2.009007845147325 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 185 247 +wz-4002 glycocholic-acid 0.689013165366348 0.5420852666887057 0.1469278986776423 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.431438127090301 0.1605351170568562 0.3366220735785953 209 1.9599890247309877 2.5581223219077263 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 112 260 +aminopentamide tubocurarine 0.5640296943944006 0.2199583453244515 0.3440713490699491 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1404682274247491 0.6923076923076923 0.3336120401337792 210 3.2496369333869217 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 179 237 +prednisolone-acetate glycocholic-acid 0.555094016087611 0.2061738671387532 0.3489201489488577 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1304347826086956 0.705685618729097 0.3317725752508361 211 1.8216565241617504 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 154 236 +wz-4002 tyrphostin-1 0.7144891740052058 0.7446547698188899 -0.030165595813684 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_1_mechanistic_probe Tier_1_mechanistic_probe True True 0.5083612040133779 0.0033444816053511 0.3316053511705686 212 1.9599890247309877 2.207292994011233 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 157 246 +etomidate nvp-tae684 0.7038339476455888 0.6245827572420237 0.0792511904035651 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.4816053511705686 0.0434782608695652 0.3282608695652174 213 1.8530080550657204 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 177 238 +aminopentamide atorvastatin 0.5801572077538049 0.2745605217928569 0.3055966859609479 0.3832026811848793 0.3456125017255544 -0.0583138830131954 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.177257525083612 0.5785953177257525 0.3177257525083612 214 3.2496369333869217 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 179 252 +loperamide pd-184352 0.6422393172424995 0.4283831923357432 0.2138561249067562 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.31438127090301 0.31438127090301 0.31438127090301 215 2.0592202618733775 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 167 241 +etomidate verteporfin 0.6900273780892825 0.5810460444938923 0.1089813335953902 0.2152146542710917 0.1923187635838985 0.189117331109527 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.4381270903010033 0.0836120401337792 0.3140468227424749 216 1.8530080550657204 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 174 239 +prednisolone-acetate nvp-tae684 0.6688466356985922 0.5295552712724736 0.1392913644261185 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.3946488294314381 0.1404682274247491 0.305685618729097 217 1.8216565241617504 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 210 246 +pre-084 duloxetine 0.6404879220210695 0.4340885560700875 0.2063993659509819 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.3076923076923077 0.294314381270903 0.3030100334448161 218 2.526038259615349 2.1732541979990767 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 199 235 +prednisolone-acetate verteporfin 0.6550400661422856 0.4860185585243419 0.1690215076179436 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.3478260869565217 0.2107023411371237 0.2998327759197324 219 1.8216565241617504 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 207 252 +loperamide tyrphostin-1 0.6914301934164194 0.6344589335134341 0.0569712599029853 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.4448160535117056 0.0301003344481605 0.2996655518394648 220 2.0592202618733775 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 193 247 +prochlorperazine tyrphostin-1 0.6544262652270614 0.4797661445872295 0.1746601206398318 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2134195044636726 0.165535744279623 0.1507142931222915 Excluded_safety Tier_1_mechanistic_probe True True 0.3411371237458194 0.2140468227424749 0.2966555183946488 221 2.4835161945213544 2.207292994011233 early_tier=Excluded_safety; late_tier=Tier_1_mechanistic_probe; both_hard_gate=True 199 256 +pre-084 ambroxol 0.6261317337316179 0.399742362747294 0.2263893709843238 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2608695652173913 0.354515050167224 0.2936454849498328 222 2.526038259615349 2.4175703242393984 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 198 236 +bibx-1382 glycocholic-acid 0.5842297568710314 0.3157158906734179 0.2685138661976134 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1939799331103679 0.4749163879598662 0.2923076923076923 223 2.15358517128177 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 199 239 +wz-4002 pd-184352 0.665298297831286 0.538579028641199 0.126719269190087 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.3812709030100334 0.1137123745819397 0.2876254180602007 224 1.9599890247309877 2.782548756150072 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 141 273 +emf-sumo1-10 wz-4002 0.637445697740149 0.4389047518276446 0.1985409459125043 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.3318178856538402 0.1799050901706019 0.1696766402040209 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.294314381270903 0.2742474916387959 0.2872909698996655 225 1.8755526661235435 3.018593789307171 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 173 272 +pre-084 tubocurarine 0.6084396947574402 0.3644779218759919 0.2439617728814482 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2207357859531772 0.3946488294314381 0.2816053511705685 226 2.526038259615349 2.099352326781365 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 196 239 +geldanamycin duloxetine 0.6637158728304451 0.5405613979701662 0.1231544748602788 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.3745819397993311 0.1070234113712374 0.2809364548494983 227 2.176621694134193 2.1732541979990767 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 187 252 +ag-490 ambroxol 0.5378280682637104 0.2310251906765477 0.3068028775871627 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1070234113712374 0.5953177257525084 0.2779264214046822 228 2.6682951078262267 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 206 258 +prochlorperazine duloxetine 0.5906744303591992 0.3446088895268204 0.2460655408323787 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Excluded_safety Tier_4_not_prioritized True False 0.2040133779264214 0.411371237458194 0.2765886287625418 229 2.4835161945213544 2.1732541979990767 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 214 251 +ag-490 tubocurarine 0.5201360292895327 0.1957607498052456 0.324375279484287 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0802675585284281 0.6354515050167224 0.2745819397993311 230 2.6682951078262267 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 209 250 +emf-sumo1-10 glycocholic-acid 0.4645377131297238 0.1014877875217253 0.3630499256079985 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0234113712374581 0.7357859531772575 0.272742474916388 231 1.8755526661235435 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 208 255 +prochlorperazine ambroxol 0.5763182420697477 0.3102626962040269 0.2660555458657207 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.1705685618729097 0.4581939799331103 0.2712374581939799 232 2.4835161945213544 2.4175703242393984 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 219 252 +ticlopidine glycocholic-acid 0.5425637035800647 0.2393060230801532 0.3032576804999114 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1103678929765886 0.568561872909699 0.2707357859531772 233 2.009007845147325 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 213 252 +pre-084 atorvastatin 0.6245672081168445 0.4190800983443973 0.2054871097724471 0.3460696306345718 0.1495749969035387 0.1047722188134988 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2575250836120401 0.2909698996655518 0.2692307692307692 234 2.526038259615349 2.075961514835675 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 210 246 +ag-490 tyrphostin-1 0.6159360914210241 0.4005286390597503 0.2154074523612738 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.2408026755852843 0.3210702341137124 0.2688963210702341 235 2.6682951078262267 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 189 276 +geldanamycin ambroxol 0.6493596845409936 0.5062152046473726 0.143144479893621 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.2222777725093894 0.214442616328597 -0.1124999905005097 Excluded_safety Tier_4_not_prioritized True False 0.3311036789297659 0.1471571906354515 0.2667224080267558 236 2.176621694134193 2.4175703242393984 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 194 256 +ag-490 duloxetine 0.552184256553162 0.2653713839993413 0.2868128725538206 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1270903010033444 0.5250836120401338 0.2663879598662207 237 2.6682951078262267 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 204 264 +prochlorperazine tubocurarine 0.55862620309557 0.2749982553327249 0.2836279477628451 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.1337792642140468 0.5083612040133779 0.2648829431438126 238 2.4835161945213544 2.099352326781365 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 219 251 +ticlopidine pd-184352 0.5188488360450026 0.2031113748782358 0.3157374611667668 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0735785953177257 0.6153846153846154 0.2632107023411371 239 2.009007845147325 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 221 250 +nu-7026 nvp-tae684 0.6373665460851043 0.469944382208355 0.1674221638767493 0.2296837022128914 0.121435706104551 0.0272444321049584 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2909698996655518 0.2040133779264214 0.2605351170568561 240 1.7581600552143564 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 205 259 +nu-7026 verteporfin 0.6235599765287978 0.4264076694602234 0.1971523070685743 0.2296837022128914 0.121435706104551 0.0272444321049584 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.2541806020066889 0.2709030100334448 0.2600334448160535 241 1.7581600552143564 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 208 263 +arcyriaflavin-a glycocholic-acid 0.6201103914322124 0.4240672066770788 0.1960431847551335 0.2513968291958527 0.135857936926186 0.176811108055214 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2474916387959866 0.2575250836120401 0.2510033444816053 242 1.9248851248778247 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 195 249 +ag-490 atorvastatin 0.536263542648937 0.2503629262736511 0.2859006163752859 0.3408095247245259 0.2174672408561621 -0.0613149003022246 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1003344481605351 0.5217391304347826 0.2478260869565217 243 2.6682951078262267 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 215 265 +prochlorperazine atorvastatin 0.5747537164549742 0.3296004318011303 0.2451532846538439 0.3393047527809228 0.148764285658087 0.0186749911970562 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.1638795986622073 0.4013377926421405 0.2469899665551839 244 2.4835161945213544 2.075961514835675 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 228 261 +geldanamycin atorvastatin 0.6477951589262201 0.5255529402444759 0.1222422186817442 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Excluded_safety Tier_4_not_prioritized True False 0.3244147157190635 0.1003344481605351 0.2459866220735786 245 2.176621694134193 2.075961514835675 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 203 262 +arcyriaflavin-a pd-184352 0.5963955238971503 0.3878725584751614 0.2085229654219889 0.2513968291958527 0.135857936926186 0.176811108055214 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2140468227424749 0.3010033444816054 0.2444816053511705 246 1.9248851248778247 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 208 256 +geldanamycin tubocurarine 0.6316676455668159 0.4709507637760705 0.1607168817907453 0.3060583371136869 0.1065098238842827 0.2312507074740198 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Excluded_safety Tier_4_not_prioritized True False 0.2742474916387959 0.1872909698996655 0.2438127090301003 247 2.176621694134193 2.099352326781365 early_tier=Excluded_safety; late_tier=Tier_4_not_prioritized; both_hard_gate=False 197 259 +etomidate glycocholic-acid 0.5900813280346078 0.3740080955497448 0.2160732324848629 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.197324414715719 0.3244147157190635 0.2418060200668896 248 1.8530080550657204 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 171 264 +emf-sumo1-10 verteporfin 0.5644837631843984 0.3145209809188686 0.2499627822655297 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.3174578201853567 0.1837441553879115 0.0395371671766042 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.1438127090301003 0.4214046822742475 0.2409698996655518 249 1.8755526661235435 2.937649773036116 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 195 282 +bibx-1382 pd-184352 0.5605148893359693 0.3091739156904319 0.2513409736455373 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1371237458193979 0.4280936454849498 0.2389632107023411 250 2.15358517128177 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 235 250 +emf-sumo1-10 pd-184352 0.4408228455946618 0.1155626304920703 0.3252602151025914 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0167224080267558 0.6387959866220736 0.234448160535117 251 1.8755526661235435 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 230 262 +emf-sumo1-10 nvp-tae684 0.578290332740705 0.3580576936670002 0.2202326390737047 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.3068421044283443 0.1615088503393862 0.1419794602053506 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1739130434782608 0.334448160535117 0.2301003344481605 252 1.8755526661235435 2.7994032456748315 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 203 290 +loperamide duloxetine 0.6276783585485572 0.480896645876032 0.1467817126725252 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2642140468227424 0.157190635451505 0.2267558528428093 253 2.0592202618733775 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 217 262 +wz-4002 duloxetine 0.6507373391373438 0.6094975147584807 0.041239824378863 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.334448160535117 0.0167224080267558 0.2232441471571906 254 1.9599890247309877 2.1732541979990767 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 184 285 +arcyriaflavin-a tyrphostin-1 0.6455864000710703 0.5939482996528522 0.051638100418218 0.2513968291958527 0.135857936926186 0.176811108055214 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.3210702341137124 0.0234113712374581 0.2168896321070234 255 1.9248851248778247 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 240 259 +loperamide ambroxol 0.6133221702591057 0.4649554851302315 0.1483666851288742 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2341137123745819 0.1672240802675585 0.2107023411371237 256 2.0592202618733775 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 228 267 +nu-7026 glycocholic-acid 0.5236139264741232 0.2636439672353425 0.2599699592387806 0.2296837022128914 0.121435706104551 0.0272444321049584 0.2927055549290445 0.113612961049916 -0.1485714369586535 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0836120401337792 0.4448160535117056 0.2100334448160535 257 1.7581600552143564 2.5581223219077263 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 241 266 +loperamide tubocurarine 0.595630131284928 0.4296910442589294 0.1659390870259985 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2073578595317725 0.2006688963210702 0.2050167224080267 258 2.0592202618733775 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 232 272 +nu-7026 pd-184352 0.4998990589390611 0.2274493190334252 0.272449739905636 0.2296837022128914 0.121435706104551 0.0272444321049584 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0535117056856187 0.4849498327759197 0.204515050167224 259 1.7581600552143564 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 247 264 +wz-4002 ambroxol 0.6363811508478922 0.5751513214356871 0.061229829412205 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2876254180602006 0.0367892976588628 0.1998327759197324 260 1.9599890247309877 2.4175703242393984 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 191 290 +prednisolone-acetate pd-184352 0.531379148552549 0.2870602080975437 0.2443189404550053 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0903010033444816 0.3979933110367893 0.1979933110367893 261 1.8216565241617504 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 247 263 +loperamide atorvastatin 0.6117576446443322 0.4842932207273348 0.1274644239169974 0.2855147977492639 0.1086321733891964 0.2002627576390902 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.2307692307692307 0.1170568561872909 0.1909698996655518 262 2.0592202618733775 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 239 273 +wz-4002 atorvastatin 0.6348166252331188 0.5944890570327905 0.0403275682003282 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2809364548494983 0.0133779264214046 0.1872909698996655 263 1.9599890247309877 2.075961514835675 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 204 292 +ticlopidine tubocurarine 0.4722396500874311 0.204419226801422 0.267820423286009 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0334448160535117 0.471571906354515 0.1867892976588628 264 2.009007845147325 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 253 271 +ticlopidine ambroxol 0.4899316890616088 0.2396836676727241 0.2502480213888846 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0468227424749163 0.4247491638795986 0.1790969899665551 265 2.009007845147325 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 248 278 +etomidate pd-184352 0.5663664604995458 0.382087694067094 0.1842787664324517 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2852154970169067 0.2008830491039487 -0.1018106751143932 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1505016722408027 0.2307692307692307 0.1785953177257525 266 1.8530080550657204 2.782548756150072 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 231 282 +emf-sumo1-10 tubocurarine 0.3942136596370902 0.1168704824152565 0.2773431772218336 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0033444816053511 0.4949832775919732 0.1754180602006688 267 1.8755526661235435 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 253 280 +wz-4002 tubocurarine 0.6186891118737144 0.539886880564385 0.0788022313093294 0.2427962143306753 0.1696766402040209 0.3318178856538402 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_1_mechanistic_probe Tier_4_not_prioritized True False 0.2441471571906354 0.040133779264214 0.1727424749163879 268 1.9599890247309877 2.099352326781365 early_tier=Tier_1_mechanistic_probe; late_tier=Tier_4_not_prioritized; both_hard_gate=False 202 295 +ticlopidine duloxetine 0.5042878773510603 0.2740298609955177 0.2302580163555426 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0635451505016722 0.3745819397993311 0.1724080267558528 269 2.009007845147325 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 250 284 +bibx-1382 tyrphostin-1 0.6097057655098891 0.5152496568681226 0.0944561086417664 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.2240802675585284 0.060200668896321 0.1667224080267558 270 2.15358517128177 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 256 273 +ticlopidine tyrphostin-1 0.5680397122189225 0.4091871160559266 0.1588525961629958 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.1605351170568562 0.177257525083612 0.1663879598662207 271 2.009007845147325 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 243 297 +emf-sumo1-10 ambroxol 0.4119056986112679 0.1521349232865586 0.2597707753247092 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0100334448160535 0.4414715719063545 0.1610367892976588 272 1.8755526661235435 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 256 287 +ticlopidine atorvastatin 0.4883671634468354 0.2590214032698275 0.2293457601770079 0.2711753677909395 0.1225165724754333 -0.017839344839255 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0434782608695652 0.3712374581939799 0.1581939799331103 273 2.009007845147325 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 258 285 +arcyriaflavin-a duloxetine 0.5818345652032081 0.4587910445924432 0.1230435206107648 0.2513968291958527 0.135857936926186 0.176811108055214 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1872909698996655 0.1036789297658862 0.1580267558528428 274 1.9248851248778247 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 259 284 +etomidate tyrphostin-1 0.6155573366734656 0.5881634352447848 0.0273939014286808 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.2374581939799331 0.0100334448160535 0.1578595317725752 275 1.8530080550657204 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 254 277 +arcyriaflavin-a ambroxol 0.5674783769137565 0.4244448512696497 0.1430335256441067 0.2513968291958527 0.135857936926186 0.176811108055214 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.157190635451505 0.1438127090301003 0.1525083612040133 276 1.9248851248778247 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 260 286 +emf-sumo1-10 duloxetine 0.4262618869007195 0.1864811166093521 0.2397807702913673 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0133779264214046 0.3879598662207358 0.1444816053511705 277 1.8755526661235435 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 265 293 +bibx-1382 duloxetine 0.545953930642027 0.3800924018077137 0.1658615288343132 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1137123745819397 0.197324414715719 0.1429765886287625 278 2.15358517128177 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 270 280 +bibx-1382 ambroxol 0.5315977423525755 0.3457462084849201 0.1858515338676554 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0936454849498327 0.2341137123745819 0.1428093645484949 279 2.15358517128177 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 270 283 +arcyriaflavin-a tubocurarine 0.5497863379395789 0.3891804103983476 0.1606059275412312 0.2513968291958527 0.135857936926186 0.176811108055214 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1204013377926421 0.1839464882943143 0.1426421404682274 280 1.9248851248778247 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 261 288 +bibx-1382 tubocurarine 0.5139057033783977 0.310481767613618 0.2034239357647796 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0668896321070234 0.2809364548494983 0.1418060200668896 281 2.15358517128177 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 270 281 +emf-sumo1-10 atorvastatin 0.4103411729964945 0.1714726588836619 0.2388685141128325 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0066889632107023 0.3846153846153846 0.1389632107023411 282 1.8755526661235435 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 268 294 +prednisolone-acetate tyrphostin-1 0.5805700247264688 0.4931359492752344 0.0874340754512343 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.1806020066889632 0.0568561872909698 0.1372909698996655 283 1.8216565241617504 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 275 287 +nu-7026 tubocurarine 0.4532898729814896 0.2287571709566113 0.2245327020248783 0.2296837022128914 0.121435706104551 0.0272444321049584 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.020066889632107 0.3444816053511705 0.1336120401337792 284 1.7581600552143564 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 278 288 +arcyriaflavin-a atorvastatin 0.565913851298983 0.4437825868667531 0.1221312644322298 0.2513968291958527 0.135857936926186 0.176811108055214 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1471571906354515 0.0969899665551839 0.1295986622073578 285 1.9248851248778247 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 266 294 +nu-7026 ambroxol 0.4709819119556673 0.2640216118279134 0.2069603001277539 0.2296837022128914 0.121435706104551 0.0272444321049584 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0301003344481605 0.2976588628762542 0.1237458193979933 286 1.7581600552143564 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 280 293 +bibx-1382 atorvastatin 0.5300332167378019 0.3650839440820235 0.1649492726557784 0.2560217449707644 0.2144357274685587 0.0958000073830286 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0869565217391304 0.1906354515050167 0.1232441471571906 287 2.15358517128177 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 276 289 +prednisolone-acetate tubocurarine 0.4847699625949774 0.2883680600207298 0.1964019025742475 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0367892976588628 0.2642140468227424 0.1163879598662207 288 1.8216565241617504 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 279 292 +prednisolone-acetate ambroxol 0.5024620015691551 0.323632500892032 0.1788295006771231 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.060200668896321 0.2207357859531772 0.1163879598662207 289 1.8216565241617504 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 289 294 +nu-7026 duloxetine 0.4853381002451189 0.298367805150707 0.1869702950944119 0.2296837022128914 0.121435706104551 0.0272444321049584 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.040133779264214 0.2441471571906354 0.1115384615384615 290 1.7581600552143564 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 284 296 +nu-7026 tyrphostin-1 0.5490899351129811 0.433525060211116 0.1155648749018651 0.2296837022128914 0.121435706104551 0.0272444321049584 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.1170568561872909 0.0869565217391304 0.1065217391304347 291 1.7581600552143564 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 272 298 +prednisolone-acetate duloxetine 0.5168181898586066 0.3579786942148255 0.158839495643781 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0702341137123745 0.1739130434782608 0.1065217391304347 291 1.8216565241617504 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 287 293 +emf-sumo1-10 tyrphostin-1 0.4900137217685816 0.3216383716697611 0.1683753500988204 0.2255065434479287 0.1770792342722416 -0.0825536770539151 0.2134195044636726 0.165535744279623 0.1507142931222915 Tier_4_not_prioritized Tier_1_mechanistic_probe True False 0.0501672240802675 0.2073578595317725 0.1051839464882943 293 1.8755526661235435 2.207292994011233 early_tier=Tier_4_not_prioritized; late_tier=Tier_1_mechanistic_probe; both_hard_gate=False 266 299 +etomidate duloxetine 0.5518055018056035 0.4530061801843758 0.0987993216212277 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2185218946801291 0.1440896673334969 -0.0665861084125936 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1237458193979933 0.0668896321070234 0.1038461538461538 294 1.8530080550657204 2.1732541979990767 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 268 297 +nu-7026 atorvastatin 0.4694173863408938 0.2833593474250168 0.186058038915877 0.2296837022128914 0.121435706104551 0.0272444321049584 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0267558528428093 0.2374581939799331 0.1005016722408026 295 1.7581600552143564 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 291 297 +etomidate ambroxol 0.5374493135161519 0.4186599868615822 0.1187893266545696 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2222777725093894 0.214442616328597 -0.1124999905005097 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.1036789297658862 0.0936454849498327 0.1001672240802675 296 1.8530080550657204 2.4175703242393984 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 269 297 +prednisolone-acetate atorvastatin 0.5008974759543816 0.3429702364891352 0.1579272394652463 0.2319165623214628 0.1410348883696965 0.0857388911147912 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0568561872909698 0.1705685618729097 0.0966555183946488 297 1.8216565241617504 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 294 299 +etomidate tubocurarine 0.5197572745419742 0.38339554599028 0.1363617285516941 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2221980144580205 0.1128484031392468 -0.0646910603557314 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0769230769230769 0.1304347826086956 0.0956521739130434 298 1.8530080550657204 2.099352326781365 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 273 299 +etomidate atorvastatin 0.5358847879013784 0.4379977224586855 0.0978870654426928 0.2152146542710917 0.1923187635838985 0.189117331109527 0.2072999146249559 0.1362054027203056 -0.1188452158655439 Tier_4_not_prioritized Tier_4_not_prioritized True False 0.0969899665551839 0.0635451505016722 0.0852842809364548 299 1.8530080550657204 2.075961514835675 early_tier=Tier_4_not_prioritized; late_tier=Tier_4_not_prioritized; both_hard_gate=False 279 299 diff --git a/docs/methods_audit/machine_readable/UQ_Biopsy_Reconstruction_Map.tsv b/docs/methods_audit/machine_readable/UQ_Biopsy_Reconstruction_Map.tsv new file mode 100644 index 0000000..79a80f7 --- /dev/null +++ b/docs/methods_audit/machine_readable/UQ_Biopsy_Reconstruction_Map.tsv @@ -0,0 +1,34 @@ +array biopsy_id component_members fibrosis_stage stage_numeric stage_group patient_cluster mapping_source n_spots assignment_evidence manual_edit included_in_analysis blinding_status alternative_assignment +VLP115_A UQ_B01 C1 F3b 3 late UQ_P01 Figure_S1E_geometric_registration 351 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP115_A UQ_B02 C2,C3 F1 1 early UQ_P02 Figure_S1E_geometric_registration 709 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP115_A UQ_B03 C4,C5 F1 1 early UQ_P03 Figure_S1E_geometric_registration 260 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP115_A UQ_B04 C6 F1 1 early UQ_P04 Figure_S1E_geometric_registration 423 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP116_D UQ_B05 C1 F3b 3 late UQ_P05 Figure_S1E_geometric_registration 514 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP116_D UQ_B06 C2,C3 F3a 3 intermediate UQ_P06 Figure_S1E_geometric_registration 197 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP116_D UQ_B07 C4 F4 4 late UQ_P07 Figure_S1E_geometric_registration 838 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP116_D UQ_B08 C5 F0 0 early UQ_P08 Figure_S1E_geometric_registration 624 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP119_A UQ_B09 C1 F1 1 early UQ_P09 Figure_S1E_geometric_registration 232 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP119_A UQ_B10 C2 F3b 3 late UQ_P10 Figure_S1E_geometric_registration 444 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP119_A UQ_B11 C3,C4,C5,C6 F2 2 intermediate UQ_P11 Figure_S1E_geometric_registration 384 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP119_A UQ_B12 C7 F1 1 early UQ_P12 Figure_S1E_geometric_registration 631 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP119_D UQ_B13 C1 F4 4 late UQ_P13 Figure_S1E_geometric_registration 190 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP119_D UQ_B14 C2 F1 1 early UQ_P14 Figure_S1E_geometric_registration 394 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP119_D UQ_B15 C3 F1 1 early UQ_P15 Figure_S1E_geometric_registration 163 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP119_D UQ_B16 C4,C5,C6 F1 1 early UQ_P16 Figure_S1E_geometric_registration 508 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP120_A UQ_B17 C1,C2 F0 0 early UQ_P17 Figure_S1E_geometric_registration 306 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP120_A UQ_B18 C3 F0 0 early UQ_P18 Figure_S1E_geometric_registration 421 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP120_A UQ_B19 C4 F3a 3 intermediate UQ_P19 Figure_S1E_geometric_registration 575 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP120_A UQ_B20 C5 F4 4 late UQ_P20 Figure_S1E_geometric_registration 582 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP120_D UQ_B21 C1 F3b 3 late UQ_SYNC Figure_S1E_geometric_registration_sync_pair_inferred 83 Figure_S1E_geometric_registration_sync_pair_inferred Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP120_D UQ_B22 C2 F3b 3 late UQ_SYNC Figure_S1E_geometric_registration_sync_pair_inferred 339 Figure_S1E_geometric_registration_sync_pair_inferred Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP120_D UQ_B23 C3 F2 2 intermediate UQ_P23 Figure_S1E_geometric_registration 620 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP120_D UQ_B24 C4 F1 1 early UQ_P24 Figure_S1E_geometric_registration 608 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP121_A UQ_B25 C1 F2 2 intermediate UQ_P25 Figure_S1E_geometric_registration 334 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP121_A UQ_B26 C2 F4 4 late UQ_P26 Figure_S1E_geometric_registration 465 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP121_A UQ_B27 C3 F4 4 late UQ_P27 Figure_S1E_geometric_registration 590 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP121_A UQ_B28 C4,C5 F4 4 late UQ_P28 Figure_S1E_geometric_registration 117 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP121_D UQ_B29 C1 F4 4 late UQ_P29 Figure_S1E_geometric_registration 361 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP121_D UQ_B30 C2 F0 0 early UQ_P30 Figure_S1E_geometric_registration 405 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP121_D UQ_B31 C3 F0 0 early UQ_P31 Figure_S1E_geometric_registration 189 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP121_D UQ_B32 C4 F3b 3 late UQ_P32 Figure_S1E_geometric_registration 284 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located +VLP121_D UQ_B33 C5 F3b 3 late UQ_P33 Figure_S1E_geometric_registration 444 Figure_S1E_geometric_registration Manual geometric registration table; operator identity not documented True Mapping timestamp precedes score outputs; strict operator blinding not documented No alternative assignment table located diff --git a/environment/R-packages.lock.tsv b/environment/R-packages.lock.tsv new file mode 100644 index 0000000..28630e6 --- /dev/null +++ b/environment/R-packages.lock.tsv @@ -0,0 +1,9 @@ +package version repository role +R 4.6.0 Homebrew runtime +Matrix 1.7-5 CRAN sparse matrices for GSE261829 +data.table 1.18.4 CRAN pseudobulk table input and output +edgeR 4.10.1 Bioconductor negative-binomial pseudobulk inference +limma 3.68.4 Bioconductor edgeR dependency and contrasts +jsonlite 2.0.0 CRAN machine-readable analysis manifests +ggplot2 4.0.3 CRAN optional figure rendering +svglite 2.2.2 CRAN optional editable SVG output diff --git a/environment/README.md b/environment/README.md new file mode 100644 index 0000000..76ab745 --- /dev/null +++ b/environment/README.md @@ -0,0 +1,20 @@ +# Reproducible environments + +## Core Python environment + +Python is constrained by `pyproject.toml` to 3.11. The installable top-level specification is `requirements-core.in`; `requirements-lock.txt` is generated with `uv pip compile` and contains the transitive lock used for blank-environment testing. + +```bash +uv venv --python 3.11 .venv +uv pip sync --python .venv/bin/python environment/requirements-lock.txt +``` + +`requirements.txt` remains as a compatibility entry point and contains only a valid requirement-file include. Python itself is intentionally declared in `pyproject.toml`, not as a pip requirement. + +## R environment + +The three pseudobulk workflows require R 4.6.0, `edgeR`, `limma`, `data.table`, `Matrix`, and `jsonlite`. Exact versions used on the local reconstruction host are recorded in `R-packages.lock.tsv`. A clean R-library test is required before release. + +## Specialized perturbation environments + +scGPT and CellOracle are separated from the core environment because they require model weights, motif resources, and platform-specific compiled dependencies. The archived RTX 5090 environment freeze is retained as `scgpt5090-pip-freeze.txt`. CellOracle is treated as Linux-only until its dedicated clean-environment test succeeds; absence from the core lock is deliberate. diff --git a/environment/requirements-core.in b/environment/requirements-core.in new file mode 100644 index 0000000..8031cea --- /dev/null +++ b/environment/requirements-core.in @@ -0,0 +1,17 @@ +numpy==2.3.5 +pandas==2.3.3 +scipy==1.16.3 +statsmodels==0.14.6 +scikit-learn==1.9.0 +matplotlib==3.10.0 +seaborn==0.13.2 +h5py==3.16.0 +pyarrow==25.0.0 +diptest>=0.9,<1 +PyYAML==6.0.3 +anndata==0.12.19 +scanpy==1.11.5 +tifffile==2026.3.3 +scikit-image==0.26.0 +openpyxl==3.1.5 +harmonypy==2.0.0 diff --git a/environment/requirements-lock.txt b/environment/requirements-lock.txt new file mode 100644 index 0000000..0343dc4 --- /dev/null +++ b/environment/requirements-lock.txt @@ -0,0 +1,208 @@ +# This file was autogenerated by uv via the following command: +# uv pip compile environment/requirements-core.in --python-version 3.11 --universal --output-file environment/requirements-lock.txt +anndata==0.12.19 + # via + # -r environment/requirements-core.in + # scanpy +array-api-compat==1.15.0 + # via anndata +colorama==0.4.6 ; sys_platform == 'win32' + # via tqdm +contourpy==1.3.3 + # via matplotlib +cycler==0.12.1 + # via matplotlib +diptest==0.11.0 + # via -r environment/requirements-core.in +donfig==0.8.1.post1 + # via zarr +et-xmlfile==2.0.0 + # via openpyxl +fonttools==4.63.0 + # via matplotlib +google-crc32c==1.8.0 + # via zarr +h5py==3.16.0 + # via + # -r environment/requirements-core.in + # anndata + # scanpy +harmonypy==2.0.0 + # via -r environment/requirements-core.in +imageio==2.37.4 + # via scikit-image +joblib==1.5.3 + # via + # pynndescent + # scanpy + # scikit-learn +kiwisolver==1.5.0 + # via matplotlib +lazy-loader==0.5 + # via scikit-image +legacy-api-wrap==1.5 + # via + # anndata + # scanpy +llvmlite==0.49.0 + # via + # numba + # pynndescent +matplotlib==3.10.0 + # via + # -r environment/requirements-core.in + # scanpy + # seaborn +narwhals==2.25.0 + # via scikit-learn +natsort==8.4.0 + # via + # anndata + # scanpy +networkx==3.6.1 + # via + # scanpy + # scikit-image +numba==0.67.0 + # via + # pynndescent + # scanpy + # umap-learn +numcodecs==0.16.5 + # via zarr +numpy==2.3.5 + # via + # -r environment/requirements-core.in + # anndata + # contourpy + # diptest + # h5py + # harmonypy + # imageio + # matplotlib + # numba + # numcodecs + # pandas + # patsy + # scanpy + # scikit-image + # scikit-learn + # scipy + # seaborn + # statsmodels + # tifffile + # umap-learn + # zarr +openpyxl==3.1.5 + # via -r environment/requirements-core.in +packaging==26.3 + # via + # anndata + # lazy-loader + # matplotlib + # scanpy + # scikit-image + # statsmodels + # zarr +pandas==2.3.3 + # via + # -r environment/requirements-core.in + # anndata + # scanpy + # seaborn + # statsmodels +patsy==1.0.2 + # via + # scanpy + # statsmodels +pillow==12.3.0 + # via + # imageio + # matplotlib + # scikit-image +psutil==7.2.2 + # via diptest +pyarrow==25.0.0 + # via -r environment/requirements-core.in +pynndescent==0.6.0 + # via + # scanpy + # umap-learn +pyparsing==3.3.2 + # via matplotlib +python-dateutil==2.9.0.post0 + # via + # matplotlib + # pandas +pytz==2026.3.post1 + # via pandas +pyyaml==6.0.3 + # via + # -r environment/requirements-core.in + # donfig +scanpy==1.11.5 + # via -r environment/requirements-core.in +scikit-image==0.26.0 + # via -r environment/requirements-core.in +scikit-learn==1.9.0 + # via + # -r environment/requirements-core.in + # pynndescent + # scanpy + # umap-learn +scipy==1.16.3 + # via + # -r environment/requirements-core.in + # anndata + # pynndescent + # scanpy + # scikit-image + # scikit-learn + # statsmodels + # umap-learn +scverse-misc==0.0.3 ; python_full_version < '3.12' + # via anndata +scverse-misc==0.1.3 ; python_full_version >= '3.12' + # via anndata +seaborn==0.13.2 + # via + # -r environment/requirements-core.in + # scanpy +session-info2==0.4.1 ; python_full_version < '3.12' + # via + # scanpy + # scverse-misc +session-info2==0.4.2 ; python_full_version >= '3.12' + # via + # scanpy + # scverse-misc +six==1.17.0 + # via python-dateutil +statsmodels==0.14.6 + # via + # -r environment/requirements-core.in + # scanpy +threadpoolctl==3.6.0 + # via scikit-learn +tifffile==2026.3.3 + # via + # -r environment/requirements-core.in + # scikit-image +tqdm==4.70.0 + # via + # scanpy + # umap-learn +typing-extensions==4.16.0 + # via + # numcodecs + # scanpy + # scverse-misc + # zarr +tzdata==2026.3 + # via pandas +umap-learn==0.5.12 + # via scanpy +zarr==3.1.6 ; python_full_version < '3.12' + # via anndata +zarr==3.3.0 ; python_full_version >= '3.12' + # via anndata diff --git a/environment/requirements.txt b/environment/requirements.txt new file mode 100644 index 0000000..4f28282 --- /dev/null +++ b/environment/requirements.txt @@ -0,0 +1 @@ +-r requirements-core.in diff --git a/environment/scgpt5090-pip-freeze.txt b/environment/scgpt5090-pip-freeze.txt new file mode 100644 index 0000000..2d7dc56 --- /dev/null +++ b/environment/scgpt5090-pip-freeze.txt @@ -0,0 +1,120 @@ +aiohappyeyeballs @ file:///home/conda/feedstock_root/build_artifacts/aiohappyeyeballs_1782986737989/work +aiohttp @ file:///home/conda/feedstock_root/build_artifacts/aiohttp_1780913282166/work +aiosignal @ file:///home/conda/feedstock_root/build_artifacts/aiosignal_1751626463503/work +anndata @ file:///home/conda/feedstock_root/build_artifacts/anndata_1724876936187/work +anyio @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_anyio_1782357087/work +array-api-compat @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_array-api-compat_1780923775/work +asttokens==3.0.1 +async-timeout @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_async-timeout_1767290444/work +attrs @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_attrs_1773935801/work +backports.zstd @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_backports.zstd_1781450813/work +Brotli @ file:///home/conda/feedstock_root/build_artifacts/brotli-split_1764016952863/work +cached-property @ file:///home/conda/feedstock_root/build_artifacts/cached_property_1783242827500/work +certifi @ file:///home/conda/feedstock_root/build_artifacts/certifi_1781719850827/work/certifi +charset-normalizer @ file:///home/conda/feedstock_root/build_artifacts/charset-normalizer_1783505251992/work +click @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_click_1783085363/work +contourpy @ file:///home/conda/feedstock_root/build_artifacts/contourpy_1744743067588/work +cycler @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_cycler_1764466758/work +datasets @ file:///home/conda/feedstock_root/build_artifacts/datasets_1723662581198/work +decorator==5.3.1 +dill @ file:///home/conda/feedstock_root/build_artifacts/dill_1706434688412/work +exceptiongroup @ file:///home/conda/feedstock_root/build_artifacts/exceptiongroup_1763918002538/work +executing==2.2.1 +filelock @ file:///home/conda/feedstock_root/build_artifacts/filelock_1783504975351/work +fonttools @ file:///home/conda/feedstock_root/build_artifacts/fonttools_1778770237442/work +frozenlist @ file:///home/conda/feedstock_root/build_artifacts/frozenlist_1779999698269/work +fsspec @ file:///home/conda/feedstock_root/build_artifacts/fsspec_1715865800631/work +h11 @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_h11_1767729720/work +h2 @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_h2_1756364871/work +h5py @ file:///home/conda/feedstock_root/build_artifacts/h5py_1775581046779/work +hf-xet @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_hf-xet_1781767564/work/hf_xet +hpack @ file:///home/conda/feedstock_root/build_artifacts/hpack_1782283902770/work +httpcore @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_httpcore_1745602916/work +httpx @ file:///home/conda/feedstock_root/build_artifacts/httpx_1733663348460/work +huggingface_hub @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_huggingface_hub_1783622007/work +hyperframe @ file:///home/conda/feedstock_root/build_artifacts/hyperframe_1737618333194/work +idna @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_idna_1781620148/work +igraph @ file:///home/conda/feedstock_root/build_artifacts/python-igraph_1761816618138/work +ipython==8.39.0 +jedi==0.20.0 +Jinja2==3.1.6 +joblib @ file:///home/conda/feedstock_root/build_artifacts/joblib_1765794027227/work +kiwisolver @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_kiwisolver_1773067043/work +legacy-api-wrap @ file:///home/conda/feedstock_root/build_artifacts/legacy-api-wrap_1762187530570/work +leidenalg @ file:///home/conda/feedstock_root/build_artifacts/leidenalg_1779687566773/work +llvmlite==0.47.0 +MarkupSafe==3.0.3 +matplotlib==3.10.9 +matplotlib-inline==0.2.2 +mpmath==1.3.0 +multidict @ file:///home/conda/feedstock_root/build_artifacts/multidict_1771610691664/work +multiprocess @ file:///home/conda/feedstock_root/build_artifacts/multiprocess_1729987574988/work +munkres==1.1.4 +natsort @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_natsort_1770905275/work +networkx @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_networkx_1731521053/work +numba @ file:///home/conda/feedstock_root/build_artifacts/numba_1778390354117/work +numpy @ file:///home/conda/feedstock_root/build_artifacts/numpy_1707225380409/work/dist/numpy-1.26.4-cp310-cp310-linux_x86_64.whl#sha256=51131fd8fc130cd168aecaf1bc0ea85f92e8ffebf211772ceb16ac2e7f10d7ca +nvidia-cublas-cu12==12.8.3.14 +nvidia-cuda-cupti-cu12==12.8.57 +nvidia-cuda-nvrtc-cu12==12.8.61 +nvidia-cuda-runtime-cu12==12.8.57 +nvidia-cudnn-cu12==9.7.1.26 +nvidia-cufft-cu12==11.3.3.41 +nvidia-cufile-cu12==1.13.0.11 +nvidia-curand-cu12==10.3.9.55 +nvidia-cusolver-cu12==11.7.2.55 +nvidia-cusparse-cu12==12.5.7.53 +nvidia-cusparselt-cu12==0.6.3 +nvidia-nccl-cu12==2.26.2 +nvidia-nvjitlink-cu12==12.8.61 +nvidia-nvtx-cu12==12.8.55 +packaging @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_packaging_1777103621/work +pandas @ file:///home/conda/feedstock_root/build_artifacts/pandas_1764614464206/work +parso==0.8.7 +patsy @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_patsy_1760998269/work +pexpect==4.9.0 +pillow @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_pillow_1782912080/work +prompt_toolkit==3.0.52 +propcache @ file:///home/conda/feedstock_root/build_artifacts/propcache_1780037624495/work +ptyprocess==0.7.0 +pure_eval==0.2.3 +pyarrow @ file:///home/conda/feedstock_root/build_artifacts/apache-arrow_1776927598434/work/python +pyarrow-hotfix @ file:///home/conda/feedstock_root/build_artifacts/pyarrow-hotfix_1745605861230/work +Pygments==2.20.0 +pynndescent @ file:///home/conda/feedstock_root/build_artifacts/pynndescent_1734193530377/work +pyparsing @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_pyparsing_1769003998/work +PySide6==6.11.1 +PySocks @ file:///home/conda/feedstock_root/build_artifacts/pysocks_1733217236728/work +python-dateutil @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_python-dateutil_1751104122/work +pytz @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_pytz_1777892201/work +PyYAML @ file:///home/conda/feedstock_root/build_artifacts/pyyaml_1770223234623/work +requests @ file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_requests_1778851103/work +scanpy @ file:///home/conda/feedstock_root/build_artifacts/scanpy_1734438743317/work +-e git+https://github.com/bowang-lab/scGPT.git@cebd6fae655b9c585a4807daa3ac31bb764f06b4#egg=scGPT +scikit-learn @ file:///home/conda/feedstock_root/build_artifacts/scikit-learn_1757406028569/work/dist/scikit_learn-1.7.2-cp310-cp310-linux_x86_64.whl#sha256=99a77396a4a114bf2c78e28c7d64a1857e925ecddb5323510bd54dacb35307ce +scikit-misc @ file:///home/conda/feedstock_root/build_artifacts/scikit-misc_1765556465559/work/dist/scikit_misc-0.0.0-cp310-cp310-linux_x86_64.whl#sha256=83d40ce697b848beb4720f1daa5c503f83566a40750c6034a16b555abb84fbe7 +scipy @ file:///home/conda/feedstock_root/build_artifacts/scipy-split_1733620567294/work/dist/scipy-1.14.1-cp310-cp310-linux_x86_64.whl#sha256=740019bfe16f745f6d6adf96dea7ea3d9fdbae7d7d45ef25a7c4361bebd87257 +seaborn @ file:///home/conda/feedstock_root/build_artifacts/seaborn-split_1733730015268/work +session-info @ 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file:///home/conda/feedstock_root/build_artifacts/bld/rattler-build_typing_extensions_1783002732/work +tzdata @ file:///home/conda/feedstock_root/build_artifacts/python-tzdata_1777068919240/work +umap-learn @ file:///home/conda/feedstock_root/build_artifacts/umap-learn_1775693605856/work +unicodedata2 @ file:///home/conda/feedstock_root/build_artifacts/unicodedata2_1770908960326/work +urllib3 @ file:///home/conda/feedstock_root/build_artifacts/urllib3_1778188571305/work +wcwidth==0.8.2 +xxhash @ file:///home/conda/feedstock_root/build_artifacts/python-xxhash_1779976827729/work +yarl @ file:///home/conda/feedstock_root/build_artifacts/yarl_1779246013999/work diff --git a/figures/main/Figure_1_Clinical_Cohort_and_Persistence.pdf b/figures/main/Figure_1_Clinical_Cohort_and_Persistence.pdf new file mode 100644 index 0000000..92a484f Binary files /dev/null and b/figures/main/Figure_1_Clinical_Cohort_and_Persistence.pdf differ diff --git a/figures/main/Figure_1_Clinical_Cohort_and_Persistence.png b/figures/main/Figure_1_Clinical_Cohort_and_Persistence.png new file mode 100644 index 0000000..4b0e9ae Binary files /dev/null and b/figures/main/Figure_1_Clinical_Cohort_and_Persistence.png differ diff --git a/figures/main/Figure_1_Clinical_Cohort_and_Persistence.svg b/figures/main/Figure_1_Clinical_Cohort_and_Persistence.svg new file mode 100644 index 0000000..6ae6314 --- /dev/null +++ b/figures/main/Figure_1_Clinical_Cohort_and_Persistence.svg @@ -0,0 +1,4748 @@ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + A + Raw elastography + 9,703 scans + 2023-03-01 to 2026-07-09 + + + Technical QC + 9,644 scans + >=10 valid; LSM IQR/M <=0.30 + + + Adult analysis + 9,562 scans + age >=18 years + + + Index cohort + 8,142 patients + one index scan per linked patient + + + Clinical linkage + Metabolic 1,490 | LIS 746 + three-source 243 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This score nominates an equal-exposure factorial experiment + and provides no observed treatment-order estimate. + + + B The complete scoring rule + + + + + + + + + + + + + 20 + + + + + + + + 30 + + + + + + + + 40 + + + + + + + + 50 + + + + Rank among 299 ordered pairs + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 27 schemes + median rank 28 + range 20-46 + + + C Weight-scheme sensitivity + + + + Order-aware LINCS scoring nominates a factorial experiment + + + + + + + + + + +D \ No newline at end of file diff --git a/figures/reviewer_revision/Fig3D_Categorical_Evidence.pdf b/figures/reviewer_revision/Fig3D_Categorical_Evidence.pdf new file mode 100644 index 0000000..2137eff Binary files /dev/null and b/figures/reviewer_revision/Fig3D_Categorical_Evidence.pdf differ diff --git a/figures/reviewer_revision/Fig3D_Categorical_Evidence.png b/figures/reviewer_revision/Fig3D_Categorical_Evidence.png new file mode 100644 index 0000000..5ce0252 Binary files /dev/null and b/figures/reviewer_revision/Fig3D_Categorical_Evidence.png differ diff --git a/figures/reviewer_revision/Fig3D_Categorical_Evidence.svg b/figures/reviewer_revision/Fig3D_Categorical_Evidence.svg new file mode 100644 index 0000000..b02a1ef --- /dev/null +++ b/figures/reviewer_revision/Fig3D_Categorical_Evidence.svg @@ -0,0 +1,718 @@ + + + + + + + + 2026-08-28T11:21:43.979410 + image/svg+xml + + + Matplotlib v3.10.0, https://matplotlib.org/ + + + + + + + + + + + + + + + + + + + + + Human HSC + disease increase + + + + + + Published HSC + ATAC + RNA + + + + + + Mouse injury + increase + + + + + + Residual after + withdrawal + + + + + + Direct functional + support + + + + + + + ITGB5 + + + + + GAS7 + + + + + SPON1 + + + + + SVEP1 + + + + + TREM2 + + + + + GPNMB + + + + + LPL + + + + + MMP14 + + + + + SPP1 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + NA + + + NA + + + + + + + + + + + + + + + NA + + + NA + + + + + + + + + + + NA + + + NA + + + NA + + + + + + + + + + + NA + + + NA + + + NA + + + + + + + + + + + NA + + + NA + + + NA + + + + + + + + + + + NA + + + HSC + retention + + + Macrophage + repair + + + Categorical evidence prevents comparison of incompatible numeric scores + + + + + + + + + + + + + criterion met + + + + + + + + + + + + directional only + + + + + + + + + + + + criterion not met + + + + + + + + + + + + not applicable + + + + + Cells report evidence type and threshold status; no cross-row magnitude scale is implied. + + + + + + + + diff --git a/figures/reviewer_revision/Fig3D_Categorical_Evidence_source.tsv b/figures/reviewer_revision/Fig3D_Categorical_Evidence_source.tsv new file mode 100644 index 0000000..c2ac0b1 --- /dev/null +++ b/figures/reviewer_revision/Fig3D_Categorical_Evidence_source.tsv @@ -0,0 +1,15 @@ +gene class "Human HSC +disease increase" "Published HSC +ATAC + RNA" "Mouse injury +increase" "Residual after +withdrawal" "Direct functional +support" +ITGB5 HSC retention 2 2 2 2 0 +GAS7 HSC retention 1 2 2 2 2 +SPON1 HSC retention 0 2 2 2 2 +SVEP1 HSC retention 1 2 2 2 0 +TREM2 Macrophage repair -1 -1 2 2 2 +GPNMB Macrophage repair -1 -1 2 2 -1 +LPL Macrophage repair -1 -1 2 2 -1 +MMP14 Macrophage repair -1 -1 2 2 -1 +SPP1 Macrophage repair -1 -1 2 2 -1 diff --git a/figures/reviewer_revision/Fig4F_CODEX_SectionConcordance.pdf b/figures/reviewer_revision/Fig4F_CODEX_SectionConcordance.pdf new file mode 100644 index 0000000..d7651df Binary files /dev/null and b/figures/reviewer_revision/Fig4F_CODEX_SectionConcordance.pdf differ diff --git a/figures/reviewer_revision/Fig4F_CODEX_SectionConcordance.png b/figures/reviewer_revision/Fig4F_CODEX_SectionConcordance.png new file mode 100644 index 0000000..30f47b4 Binary files /dev/null and b/figures/reviewer_revision/Fig4F_CODEX_SectionConcordance.png differ diff --git a/figures/reviewer_revision/Fig4F_CODEX_SectionConcordance.svg b/figures/reviewer_revision/Fig4F_CODEX_SectionConcordance.svg new file mode 100644 index 0000000..04e83c2 --- /dev/null +++ b/figures/reviewer_revision/Fig4F_CODEX_SectionConcordance.svg @@ -0,0 +1,206 @@ + + + + + + + + 2026-08-28T11:21:46.035007 + image/svg+xml + + + Matplotlib v3.10.0, https://matplotlib.org/ + + + + + + + + + + + + + + + + + + + + F1 + + + + + F2 + + + + + F4 + + + + Fibrosis stage represented by the section + + + + + + + + + −0.6 + + + + + + + + −0.4 + + + + + + + + −0.2 + + + + + + + + 0.0 + + + + + + + + 0.2 + + + + + + + + 0.4 + + + + + + + + 0.6 + + + + Vimentin - CD31 enrichment + in collagen-rich patches + + + + + + + + + + + + + + + + + + + + + + -0.387 + + + 1 section + + + -0.265 + + + 1 section + + + +0.474 + + + 1 section + + + Section-specific CODEX concordance + + + + Descriptive sections: one F1, one F2, and one F4 biopsy. Bars are not connected and do not estimate a stage trend. + + + + + + + + diff --git a/figures/reviewer_revision/Fig6_Static_TwoComponent_Revision.pdf b/figures/reviewer_revision/Fig6_Static_TwoComponent_Revision.pdf new file mode 100644 index 0000000..007e388 Binary files /dev/null and b/figures/reviewer_revision/Fig6_Static_TwoComponent_Revision.pdf differ diff --git a/figures/reviewer_revision/Fig6_Static_TwoComponent_Revision.png b/figures/reviewer_revision/Fig6_Static_TwoComponent_Revision.png new file mode 100644 index 0000000..8a7301e Binary files /dev/null and b/figures/reviewer_revision/Fig6_Static_TwoComponent_Revision.png differ diff --git a/figures/reviewer_revision/Fig6_Static_TwoComponent_Revision.svg b/figures/reviewer_revision/Fig6_Static_TwoComponent_Revision.svg new file mode 100644 index 0000000..02396ac --- /dev/null +++ b/figures/reviewer_revision/Fig6_Static_TwoComponent_Revision.svg @@ -0,0 +1,11523 @@ + + + + + + + + 2026-08-28T11:21:52.946365 + image/svg+xml + + + Matplotlib v3.10.0, https://matplotlib.org/ + + + + + + + + + + + + + + + + + + + + + + + −1.0 + + + + + + + + −0.5 + + + + + + + + 0.0 + + + + + + + + 0.5 + + + + + + + + 1.0 + + + + + + + + 1.5 + + + + Repair program axis + + + + + + + + + −1.5 + + + + + + + + −1.0 + + + + + + + + −0.5 + + + + + + + + 0.0 + + + + + + + + 0.5 + + + + + + + + 1.0 + + + + + + + + 1.5 + + + + + + + + 2.0 + + + + + + + + 2.5 + + + + HSC-retention axis + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 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+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + repair-dominant + + + retention-dominant + + + A Static two-component fit to 589 spatial blocks + + + + + + + + + + + + + + + + + + + + + + + F0 + + + + + + F1 + + + + + + F2 + + + + + + F3 + + + + + + F4 + + + + + + + + + + + + + + 1 + + + + + + + + 2 + + + + + + + + 3 + + + + + + + + 4 + + + + + + + + 5 + + + + Number of Gaussian components + + + + + + + + + 0 + + + + + + + + 20 + + + + + + + + 40 + + + + + + + + 60 + + + + + + + + 80 + + + + + + + + 100 + + + + + + + + 120 + + + + + + + + 140 + + + + BIC above minimum + + + + + + + + + + + + + + + + + + + + + + + + + + BIC(1) - BIC(2) = 141.0 + LOPO median agreement = 1.000 + minimum agreement = 0.972 + + + B Model selection and refit stability + + + + + + + + + + + + + + + + + + + + + F0 + + + + + + + + F1 + + + + + + + + F2 + + + + + + + + F3 + + + + + + + + F4 + + + + Fibrosis stage + + + + + + + + + 0.0 + + + + + + + + 0.2 + + + + + + + + 0.4 + + + + + + + + 0.6 + + + + + + + + 0.8 + + + + + + + + 1.0 + + + + Patient-level tissue fraction + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + Retention-dominant fraction: beta=+0.039/stage + permutation FDR=0.0003 + + + C Stage changes component occupancy + + + + + + + + + repair-dominant + + + + + + + + transitional + + + + + + + + retention-dominant + + + + + + + + + + + + + + −1.5 + + + + + + + + −1.0 + + + + + + + + −0.5 + + + + + + + + 0.0 + + + + + + + + 0.5 + + + + Repair axis (mouse z-score) + + + + + + + + + −1.5 + + + + + + + + −1.0 + + + + + + + + −0.5 + + + + + + + + 0.0 + + + + + + + + 0.5 + + + + HSC-retention axis (mouse z-score) + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 9 mice (3/group) + residual distance = 69.8% of progression + + + D Replicated withdrawal remains displaced + + + + + + + + + + + + + + + + + + + + + + + Control + + + + + + + + Fibrosis + + + + + + + + Regression + + + + + A reproducible two-component spatial distribution accompanies incomplete recovery + + + The Gaussian mixture is a static distributional model. Contours are posterior probabilities, and arrows show observed group-centroid contrasts. + + + + + + + + + + + + + + + + + diff --git a/figures/reviewer_revision/Fig7D_OrderAwareScore_Audit.pdf b/figures/reviewer_revision/Fig7D_OrderAwareScore_Audit.pdf new file mode 100644 index 0000000..8c14cd1 Binary files /dev/null and b/figures/reviewer_revision/Fig7D_OrderAwareScore_Audit.pdf differ diff --git a/figures/reviewer_revision/Fig7D_OrderAwareScore_Audit.png b/figures/reviewer_revision/Fig7D_OrderAwareScore_Audit.png new file mode 100644 index 0000000..dbd3580 Binary files /dev/null and b/figures/reviewer_revision/Fig7D_OrderAwareScore_Audit.png differ diff --git a/figures/reviewer_revision/Fig7D_OrderAwareScore_Audit.svg b/figures/reviewer_revision/Fig7D_OrderAwareScore_Audit.svg new file mode 100644 index 0000000..fb611e7 --- /dev/null +++ b/figures/reviewer_revision/Fig7D_OrderAwareScore_Audit.svg @@ -0,0 +1,336 @@ + + + + + + + + 2026-08-28T11:21:53.514170 + image/svg+xml + + + Matplotlib v3.10.0, https://matplotlib.org/ + + + + + + + + + + + + + + + + + + + + + + + Ezetimibe + as early role + + + + + + + + Verteporfin + as early role + + + + + + + + + + 0.0 + + + + + + + + 0.2 + + + + + + + + 0.4 + + + + + + + + 0.6 + + + + + + + + 0.8 + + + + + + + + 1.0 + + + + Role-weighted score + + + + + + + + + + + + + + + + 0.892 + + + 0.504 + + + formula difference + +0.388 + + + A Same profiles, exchanged roles + + + + + + + + E(e->l) = E(e) + 0.5 E(l) + M(e->l) = M(e) + 0.5 M(l) + R(e->l) = R(l) + 0.5 R(e) + P = 1.5 max[0, -min(E, M)] + + S(e->l) = R + 0.5 E + 0.5 M - P + A = S(e->l) - S(l->e) + + + The asymmetric early/late coefficients generate the forward-reverse + contrast. This score nominates an equal-exposure factorial experiment + and provides no observed treatment-order estimate. + + + B The complete scoring rule + + + + + + + + + + + + + 20 + + + + + + + + 30 + + + + + + + + 40 + + + + + + + + 50 + + + + Rank among 299 ordered pairs + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + 27 schemes + median rank 28 + range 20-46 + + + C Weight-scheme sensitivity + + + + Order-aware LINCS scoring nominates a factorial experiment + + + + + + + + + + + diff --git a/figures/reviewer_revision/replacement_panel_manifest.tsv b/figures/reviewer_revision/replacement_panel_manifest.tsv new file mode 100644 index 0000000..3fb2569 --- /dev/null +++ b/figures/reviewer_revision/replacement_panel_manifest.tsv @@ -0,0 +1,5 @@ +output_stem primary_input interpretation +Fig3D_Categorical_Evidence data/figure_reconstruction/integrated_retention_candidates.tsv categorical evidence; no shared numeric scale +Fig4F_CODEX_SectionConcordance data/figure_reconstruction/UQ_CODEX_scar_enrichment.tsv one section per displayed stage; descriptive +Fig6_Static_TwoComponent_Revision data/UQ_spatial_derived/S11_UQ_phase_basin_control/phase_spatial_blocks.parquet static full-covariance two-component GMM +Fig7D_OrderAwareScore_Audit data/UQ_spatial_derived/S12_sequential_basin_switch_drugs/LINCS_ordered_basin_switch_pairs.tsv asymmetric role-weighted computational score diff --git a/figures/source_panels/Fig7A_Evidence_Coded_Mechanism.pdf b/figures/source_panels/Fig7A_Evidence_Coded_Mechanism.pdf new file mode 100644 index 0000000..43dad76 Binary files /dev/null and b/figures/source_panels/Fig7A_Evidence_Coded_Mechanism.pdf differ diff --git a/figures/source_panels/Fig7A_Evidence_Coded_Mechanism.png b/figures/source_panels/Fig7A_Evidence_Coded_Mechanism.png new file mode 100644 index 0000000..3d01fcf Binary files /dev/null and b/figures/source_panels/Fig7A_Evidence_Coded_Mechanism.png differ diff --git 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+ + 2000 + + + + Analysis spots + + + + + + + + + + A Geometry-only component recovery + + + + + + + Direct hex component + + + + + + Nearest-component rescue + + + + + + + + + + + + + + + + + + + 0.000 + + + + + + + + + + 0.025 + + + + + + + + + + 0.050 + + + + + + + + + + 0.075 + + + + + + + + + + 0.100 + + + + + + + + + + 0.125 + + + + + + + + + + 0.150 + + + + Array-adjusted stage effect (95% HC3 CI) + + + + + + + + + + + Registered biopsies + + + + + + + + + + No rescued fragments + + + + + + + + + + Split geometric components + + + + + + + + + + Split + no rescue + + + + + + + + + + Exclude sync pair + + + + + + + + + + Exclude merged cores + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + B Largest retention domain + + + + + + + + + + + + + + + + + + −0.05 + + + + + + + + + + −0.04 + + + + + + + + + + −0.03 + + + + + + + + + + −0.02 + + + + + + + + + + −0.01 + + + + + + + + + + 0.00 + + + + Array-adjusted stage effect (95% HC3 CI) + + + + + + + + + + + Registered biopsies + + + + + + + + + + No rescued fragments + + + + + + + + + + Split geometric components + + + + + + + + + + Split + no rescue + + + + + + + + + + Exclude sync pair + + + + + + + + + + Exclude merged cores + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + C Resolver-retention interface + + + + Spatial retention-domain conclusions survive biopsy-registration stress tests + + + + + + + + + + + + + + diff --git a/figures/supplementary/Supplementary_Figure_S4.png b/figures/supplementary/Supplementary_Figure_S4.png new file mode 100644 index 0000000..853e88a Binary files /dev/null and b/figures/supplementary/Supplementary_Figure_S4.png differ diff --git a/figures/supplementary/Supplementary_Figure_S5.png b/figures/supplementary/Supplementary_Figure_S5.png new file mode 100644 index 0000000..4505cf6 Binary files /dev/null and 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b/figures/supplementary/Supplementary_Figure_S9.png differ diff --git a/pyproject.toml b/pyproject.toml new file mode 100644 index 0000000..4b34da6 --- /dev/null +++ b/pyproject.toml @@ -0,0 +1,27 @@ +[project] +name = "pathoniche-spatial-retention" +version = "2.1.0.dev0" +description = "Reproducible analyses for stellate-cell retention and spatial scar occupation in liver fibrosis" +requires-python = ">=3.11,<3.12" +dependencies = [ + "numpy==2.3.5", + "pandas==2.3.3", + "scipy==1.16.3", + "statsmodels==0.14.6", + "scikit-learn==1.9.0", + "matplotlib==3.10.0", + "seaborn==0.13.2", + "h5py==3.16.0", + "pyarrow==25.0.0", + "diptest>=0.9,<1", + "PyYAML==6.0.3", + "anndata==0.12.19", + "scanpy==1.11.5", + "tifffile==2026.3.3", + "scikit-image==0.26.0", + "openpyxl==3.1.5", + "harmonypy==2.0.0", +] + +[tool.uv] +package = false diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_BIOPSY_MAPPING_AUDIT.md b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_BIOPSY_MAPPING_AUDIT.md new file mode 100644 index 0000000..29c5543 --- /dev/null +++ b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_BIOPSY_MAPPING_AUDIT.md @@ -0,0 +1,27 @@ +# UQ biopsy reconstruction and mapping sensitivity audit + +## Decision + +The spatial-retention result is robust to the principal reconstruction choices tested here. The largest retention-domain effect and interface-compression effect retained their expected directions in 12/12 prespecified mapping scenarios and 16/16 leave-one-array-out tests. + +## Score-independent reconstruction + +The audit recovered 13,539 spots directly from Visium hex-grid connected components. All directly recovered spots matched their archived component labels (100.000%). A further 46 spots belonged to small disconnected fragments and had previously been assigned to the nearest registered component. Removing those rescued spots did not reverse either key result. Component construction and registration checking used array identity, barcodes, spatial coordinates, and the archived biopsy table. ECM, HSC-retention, endothelial/macrophage resolver, repair, and fitted-state scores were excluded from assignment. + +The archived map contains 7 biopsies assembled from more than one geometric component and 2 biopsy entries from one inferred synchronous pair. Splitting every component into its own analysis unit, excluding all multicomponent biopsies, and excluding the inferred pair each preserved the key effect directions. + +## Key estimates + +Registered-biopsy analysis: + +- Largest retention domain per stage: beta = 0.0960; within-array permutation q = 0.0004. +- Resolver-retention interface per stage: beta = -0.0287; within-array permutation q = 0.0002. + +Geometry-component analysis with rescued fragments removed: + +- Largest retention domain per stage: beta = 0.0722; within-array permutation q = 0.0154. +- Resolver-retention interface per stage: beta = -0.0227; within-array permutation q = 0.0325. + +## Audit boundary + +The independent computational reconstruction is score-blind by construction. The original operator's strict blinding to ECM, retention, and repair scores is not documented in the historical archive. The defensible manuscript wording is that the reconstruction table predates score generation and that an independent score-excluded reconstruction plus mapping sensitivity analysis reproduced the conclusions. The original per-spot `*_samples.csv` files referenced by the source study code are not present in the local archive and remain the only unresolved provenance item. diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.pdf b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.pdf new file mode 100644 index 0000000..7d38d98 Binary files /dev/null and b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.pdf differ diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.png b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.png new file mode 100644 index 0000000..d5022fe Binary files /dev/null and b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.png differ diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.svg b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.svg new file mode 100644 index 0000000..e03e34e --- /dev/null +++ b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity.svg @@ -0,0 +1,880 @@ + + + + + + + + 2026-08-28T11:58:02.007106 + image/svg+xml + + + Matplotlib v3.10.0, https://matplotlib.org/ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + VLP115_A + + + + + + + + + + VLP116_D + + + + + + + + + + VLP119_A + + + + + + + + + + VLP119_D + + + + + + + + + + VLP120_A + + + + + + + + + + VLP120_D + + + + + + + + + + VLP121_A + + + + + + + + + + VLP121_D + + + + + + + + + + + + + + + 0 + + + + + + + + + + 250 + + + + + + + + + + 500 + + + + + + + + + + 750 + + + + + + + + + + 1000 + + + + + + + + + + 1250 + + + + + + + + + + 1500 + + + + + + + + + + 1750 + + + + + + + + + + 2000 + + + + Analysis spots + + + + + + + + + + A Geometry-only component recovery + + + + + + + Direct hex component + + + + + + Nearest-component rescue + + + + + + + + + + + + + + + + + + + 0.000 + + + + + + + + + + 0.025 + + + + + + + + + + 0.050 + + + + + + + + + + 0.075 + + + + + + + + + + 0.100 + + + + + + + + + + 0.125 + + + + + + + + + + 0.150 + + + + Array-adjusted stage effect (95% HC3 CI) + + + + + + + + + + + Registered biopsies + + + + + + + + + + No rescued fragments + + + + + + + + + + Split geometric components + + + + + + + + + + Split + no rescue + + + + + + + + + + Exclude sync pair + + + + + + + + + + Exclude merged cores + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + B Largest retention domain + + + + + + + + + + + + + + + + + + −0.05 + + + + + + + + + + −0.04 + + + + + + + + + + −0.03 + + + + + + + + + + −0.02 + + + + + + + + + + −0.01 + + + + + + + + + + 0.00 + + + + Array-adjusted stage effect (95% HC3 CI) + + + + + + + + + + + Registered biopsies + + + + + + + + + + No rescued fragments + + + + + + + + + + Split geometric components + + + + + + + + + + Split + no rescue + + + + + + + + + + Exclude sync pair + + + + + + + + + + Exclude merged cores + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + C Resolver-retention interface + + + + Spatial retention-domain conclusions survive biopsy-registration stress tests + + + + + + + + + + + + + + diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity_summary.json b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity_summary.json new file mode 100644 index 0000000..641ff9a --- /dev/null +++ b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_biopsy_mapping_sensitivity_summary.json @@ -0,0 +1,31 @@ +{ + "analysis_scope": "UQ MASLD Visium biopsy reconstruction and spatial topology", + "geometry_assignment_inputs": [ + "array identifier", + "Visium barcode", + "hex-grid array_row and array_col", + "connected-component membership" + ], + "scores_excluded_from_assignment": [ + "ECM_scar", + "HSC_retention", + "Endo_resolver", + "LAM_resolver", + "repair/resolver composite scores", + "p_locked" + ], + "direct_geometry_spots": 13539, + "nearest_component_rescue_spots": 46, + "direct_geometry_match_rate": 1.0, + "registration_table_match_rate": 1.0, + "registered_biopsies": 33, + "patient_clusters": 32, + "multicomponent_biopsies": 7, + "inferred_synchronous_biopsies": 2, + "scenario_key_direction_pass": 12, + "scenario_key_direction_total": 12, + "leave_one_array_out_key_direction_pass": 16, + "leave_one_array_out_key_direction_total": 16, + "historical_operator_blinding": "not documented", + "independent_reconstruction_conclusion": "The current geometry-only audit reproduces component membership without consulting ECM, retention, resolver, repair, or fitted-state scores. Historical strict operator blinding cannot be established from the archived record." +} diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_geometry_reconstruction_summary.tsv b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_geometry_reconstruction_summary.tsv new file mode 100644 index 0000000..107bc2a --- /dev/null +++ b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_geometry_reconstruction_summary.tsv @@ -0,0 +1,9 @@ +array n_analysis_spots n_direct_geometry_spots n_rescued_fragment_spots n_direct_component_matches direct_component_match_rate n_registration_matches registration_match_rate +VLP115_A 1743 1728 15 1728 1.0 1743 1.0 +VLP116_D 2173 2173 0 2173 1.0 2173 1.0 +VLP119_A 1691 1685 6 1685 1.0 1691 1.0 +VLP119_D 1255 1245 10 1245 1.0 1255 1.0 +VLP120_A 1884 1878 6 1878 1.0 1884 1.0 +VLP120_D 1650 1646 4 1646 1.0 1650 1.0 +VLP121_A 1506 1501 5 1501 1.0 1506 1.0 +VLP121_D 1683 1683 0 1683 1.0 1683 1.0 diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_leave_one_array_out.tsv b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_leave_one_array_out.tsv new file mode 100644 index 0000000..72ada6a --- /dev/null +++ b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_leave_one_array_out.tsv @@ -0,0 +1,33 @@ +scenario excluded_array metric n_units n_biopsies n_patients n_arrays stage_beta_array_adjusted stage_beta_se_hc3 hc3_p_value patient_cluster_p_value within_array_permutation_p spearman_rho spearman_p_value permutation_fdr +leave_out_VLP115_A VLP115_A locked_fraction 29 29 28 7 0.03262556681852455 0.008336876522408979 9.100404945808159e-05 1.7687848986725443e-06 0.0005 0.5993559493782807 0.0005907285992296048 0.001 +leave_out_VLP115_A VLP115_A largest_locked_domain_fraction 29 29 28 7 0.09671516625708296 0.026920812247389035 0.0003274203403339323 4.6950096540099895e-06 0.0015 0.6690661230101413 7.239973658932e-05 0.0015 +leave_out_VLP115_A VLP115_A locked_domain_coherence 29 29 28 7 0.10057500236596774 0.03643871783952887 0.005778125732495194 0.000483805737941908 0.0015 0.6496179948592237 0.00013706791212493328 0.0015 +leave_out_VLP115_A VLP115_A interface_edge_fraction 29 29 28 7 -0.028629989894876806 0.008565702508253557 0.0008305777138780523 3.582190630806787e-05 0.0005 -0.5910210373136017 0.000735565249293676 0.001 +leave_out_VLP116_D VLP116_D locked_fraction 29 29 28 7 0.03460995027491359 0.008800591419220242 8.400242778927521e-05 1.856791290267046e-06 0.001 0.6003705211936099 0.0005749330576243399 0.001 +leave_out_VLP116_D VLP116_D largest_locked_domain_fraction 29 29 28 7 0.11335807231684687 0.019306560743238603 4.319234577477391e-09 2.27110364615848e-12 0.001 0.6763988691708507 5.6226928700857854e-05 0.001 +leave_out_VLP116_D VLP116_D locked_domain_coherence 29 29 28 7 0.12293759689330681 0.027668409610932768 8.8611058591908e-06 1.0822435405263712e-07 0.0005 0.6763988691708507 5.6226928700857854e-05 0.001 +leave_out_VLP116_D VLP116_D interface_edge_fraction 29 29 28 7 -0.031315576875124145 0.0088332583664993 0.0003923305698776501 1.3821196710791535e-05 0.001 -0.6363572725695039 0.00020660197746087423 0.001 +leave_out_VLP119_A VLP119_A locked_fraction 29 29 28 7 0.03141842051279248 0.00801715448693553 8.895429432902525e-05 1.6756748894616486e-06 0.001 0.6313907863740373 0.0002397558392344959 0.0013333333333333333 +leave_out_VLP119_A VLP119_A largest_locked_domain_fraction 29 29 28 7 0.09405120957585414 0.025741378452263815 0.000258490807790532 3.0132470518143298e-06 0.001 0.6805045845121942 4.8655263608633105e-05 0.0013333333333333333 +leave_out_VLP119_A VLP119_A locked_domain_coherence 29 29 28 7 0.09862308233083927 0.03542273769364648 0.0053664157376672565 0.0004251134234890159 0.0015 0.6524033907321147 0.00012543708548840726 0.0015 +leave_out_VLP119_A VLP119_A interface_edge_fraction 29 29 28 7 -0.027864712395268502 0.008356957300973168 0.0008551033793219924 3.6818111383372895e-05 0.001 -0.6248085247678926 0.00029089738764524075 0.0013333333333333333 +leave_out_VLP119_D VLP119_D locked_fraction 29 29 28 7 0.031151048058750117 0.008397423581846166 0.00020759031909874033 4.662685001952998e-06 0.0005 0.6364588542440623 0.000205968486714756 0.001 +leave_out_VLP119_D VLP119_D largest_locked_domain_fraction 29 29 28 7 0.08752532013930006 0.026370748840419914 0.0009033055734695291 2.3009957419481575e-05 0.0015 0.6478467860297413 0.00014495221558936776 0.002 +leave_out_VLP119_D VLP119_D locked_domain_coherence 29 29 28 7 0.08860100399400353 0.03612117238070443 0.014171648647440496 0.001957695993437535 0.0045 0.6362057890932695 0.0002075498706905911 0.0045 +leave_out_VLP119_D VLP119_D interface_edge_fraction 29 29 28 7 -0.026063922287682756 0.008333921210283146 0.0017632978082382184 0.00010486820702326161 0.0005 -0.6083686225060541 0.00046284163796005395 0.001 +leave_out_VLP120_A VLP120_A locked_fraction 29 29 28 7 0.034902537540129994 0.008269653399739358 2.4370021073475066e-05 1.3153102888327824e-07 0.0005 0.6582689111837082 0.00010376617323920721 0.001 +leave_out_VLP120_A VLP120_A largest_locked_domain_fraction 29 29 28 7 0.09358642321052112 0.03360379898343409 0.005352849413931943 0.00024210152981550502 0.0015 0.624720070922608 0.00029164555700621263 0.002 +leave_out_VLP120_A VLP120_A locked_domain_coherence 29 29 28 7 0.09236362633282581 0.04545035620027957 0.042134721072332314 0.008133714970397457 0.0065 0.588121336092317 0.0007927780593010289 0.0065 +leave_out_VLP120_A VLP120_A interface_edge_fraction 29 29 28 7 -0.030406042005267295 0.009695382607289988 0.0017118958244379844 6.339656745564096e-05 0.0005 -0.619128597545758 0.00034252657458854065 0.001 +leave_out_VLP120_D VLP120_D locked_fraction 29 29 29 7 0.032462596946896245 0.00830412652488677 9.259740456208221e-05 1.8225354848864156e-06 0.0005 0.6187325909776051 0.0003464099506243277 0.0006666666666666666 +leave_out_VLP120_D VLP120_D largest_locked_domain_fraction 29 29 29 7 0.09054316763208049 0.026112282711547728 0.0005254115275894769 8.997724094778692e-06 0.0015 0.6488590960211137 0.00014039821963383832 0.0015 +leave_out_VLP120_D VLP120_D locked_domain_coherence 29 29 29 7 0.09194463474507202 0.03535887245935984 0.009313493490794057 0.0009600161113010018 0.0005 0.6303781307423229 0.00024706543593206826 0.0006666666666666666 +leave_out_VLP120_D VLP120_D interface_edge_fraction 29 29 29 7 -0.027538073890393873 0.00832420902701113 0.0009390072386258838 4.7109538879308376e-05 0.0005 -0.6091123624763167 0.0004534678756035851 0.0006666666666666666 +leave_out_VLP121_A VLP121_A locked_fraction 29 29 28 7 0.02989761507074172 0.007700299056340003 0.00010332153711389082 2.0298195839680532e-06 0.001 0.6945152460049331 2.9184316316623038e-05 0.001 +leave_out_VLP121_A VLP121_A largest_locked_domain_fraction 29 29 28 7 0.09959957839478475 0.026406540298144314 0.0001620891592839749 1.2751798741388341e-06 0.0005 0.7506067856969615 2.734347385745218e-06 0.0006666666666666666 +leave_out_VLP121_A VLP121_A locked_domain_coherence 29 29 28 7 0.10844030224758656 0.035228465719885964 0.002082543213450493 8.151151014008993e-05 0.0005 0.7128724771768696 1.4289353750303566e-05 0.0006666666666666666 +leave_out_VLP121_A VLP121_A interface_edge_fraction 29 29 28 7 -0.027395755336671702 0.008337999831872162 0.0010174708342360463 4.692767578369e-05 0.0005 -0.6328145523437019 0.0002298020493437274 0.0006666666666666666 +leave_out_VLP121_D VLP121_D locked_fraction 28 28 27 7 0.03325467386929405 0.010274467651324873 0.0012094914676357863 5.1278132163886856e-05 0.001 0.5684755938370202 0.0015984073496643995 0.002 +leave_out_VLP121_D VLP121_D largest_locked_domain_fraction 28 28 27 7 0.09332898871434908 0.033120730589138614 0.004834758111422451 0.00016734163874330545 0.0025 0.6139197699084006 0.0005112344319994489 0.0033333333333333335 +leave_out_VLP121_D VLP121_D locked_domain_coherence 28 28 27 7 0.09346815241207203 0.043205731740251066 0.0305159909106348 0.0041277451199398674 0.011 0.5902097650015934 0.0009462281338034456 0.011 +leave_out_VLP121_D VLP121_D interface_edge_fraction 28 28 27 7 -0.031736834959632594 0.009397792444899158 0.0007326716386957857 1.0106912697208329e-05 0.0005 -0.616460127576987 0.00047720593688835056 0.002 diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_scenario_stage_trends.tsv b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_scenario_stage_trends.tsv new file mode 100644 index 0000000..320b7b1 --- /dev/null +++ b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_scenario_stage_trends.tsv @@ -0,0 +1,25 @@ +scenario metric n_units n_biopsies n_patients n_arrays stage_beta_array_adjusted stage_beta_se_hc3 hc3_p_value patient_cluster_p_value within_array_permutation_p spearman_rho spearman_p_value permutation_fdr +registered_biopsy_all locked_fraction 33 33 32 8 0.03243871913389098 0.007845394308650935 3.553461718547866e-05 4.819730206140662e-07 0.0001 0.625235989768342 0.00010012679857715094 0.0002 +registered_biopsy_all largest_locked_domain_fraction 33 33 32 8 0.09603914800529065 0.025213952123085668 0.00013954776364168145 1.4218007722536753e-06 0.0003 0.6661168044839644 2.3233762701787604e-05 0.00039999999999999996 +registered_biopsy_all locked_domain_coherence 33 33 32 8 0.0997187593043891 0.034171538258863876 0.003520790685010989 0.00024666629629747455 0.0009 0.6427563389321802 5.494690318457969e-05 0.0009 +registered_biopsy_all interface_edge_fraction 33 33 32 8 -0.028733200324141162 0.008048447020384287 0.0003569398378699087 1.0948585848420734e-05 0.0001 -0.6173346558317091 0.00012971777629381808 0.0002 +registered_biopsy_no_fragment_rescue locked_fraction 33 33 32 8 0.03174354598771453 0.007856586386990954 5.336607009917123e-05 9.021356368053652e-07 0.0003 0.5977530891191841 0.00023936557168578975 0.00039999999999999996 +registered_biopsy_no_fragment_rescue largest_locked_domain_fraction 33 33 32 8 0.09727096797069296 0.025750412532538396 0.00015844051875435572 1.7404901582695138e-06 0.0003 0.6564977892567592 3.3412205278929236e-05 0.00039999999999999996 +registered_biopsy_no_fragment_rescue locked_domain_coherence 33 33 32 8 0.10192144332321097 0.03494699335230376 0.003540302227491767 0.0002455393462410101 0.0008 0.6558655206278727 3.4204459660299495e-05 0.0008 +registered_biopsy_no_fragment_rescue interface_edge_fraction 33 33 32 8 -0.02841471865118748 0.007937100028305479 0.00034361068332842043 1.063231344685454e-05 0.0001 -0.6145863657667934 0.00014171212949030092 0.00039999999999999996 +geometry_component_split_all locked_fraction 43 33 32 8 0.026289524019493637 0.00821035661775508 0.0013647918338750159 0.00044019324480257715 0.0065 0.4323932947946802 0.003783082277216579 0.0162 +geometry_component_split_all largest_locked_domain_fraction 43 33 32 8 0.07043416780347814 0.02504235138650379 0.004914243354830355 0.0011217458515367458 0.0081 0.4115373155406424 0.006110983370568862 0.0162 +geometry_component_split_all locked_domain_coherence 43 33 32 8 0.07011193957784202 0.03292819612692095 0.03323464196844317 0.011766640541962185 0.0261 0.34271559820977626 0.024466139167885665 0.0311 +geometry_component_split_all interface_edge_fraction 43 33 32 8 -0.023153962464091883 0.009155316126930518 0.011438204759180625 0.002124388401783843 0.0311 -0.4489075088508514 0.002532400131169454 0.0311 +geometry_component_split_no_fragment_rescue locked_fraction 43 33 32 8 0.02559541718698103 0.00808376300947284 0.0015440471502183332 0.0005842354742713699 0.0077 0.41525882856738516 0.005621951240879601 0.0154 +geometry_component_split_no_fragment_rescue largest_locked_domain_fraction 43 33 32 8 0.072192275987149 0.025438558806885364 0.004541034509500409 0.0010164592568559989 0.007 0.43650246542837534 0.0034298019242236157 0.0154 +geometry_component_split_no_fragment_rescue locked_domain_coherence 43 33 32 8 0.07313256683790904 0.03345290151957716 0.028805712581628687 0.00950643312410705 0.0204 0.38382334342222235 0.011057270811458063 0.027200000000000002 +geometry_component_split_no_fragment_rescue interface_edge_fraction 43 33 32 8 -0.02274588819586682 0.009075772280951352 0.012202943044265321 0.002375819894749927 0.0325 -0.4471242838588705 0.0026470996498295183 0.0325 +exclude_inferred_synchronous_pair locked_fraction 31 31 31 8 0.032473538777367306 0.008217285096294286 7.754695339538778e-05 1.8260376866214423e-06 0.0005 0.6103135110272215 0.0002665978752102941 0.0006666666666666666 +exclude_inferred_synchronous_pair largest_locked_domain_fraction 31 31 31 8 0.09038386748796808 0.0258175905225753 0.00046375282717775836 9.37133595543571e-06 0.0005 0.6413674549397328 0.0001010543330171768 0.0006666666666666666 +exclude_inferred_synchronous_pair locked_domain_coherence 31 31 31 8 0.09183053624686402 0.034965870169486976 0.008632108576614391 0.0009777168169254355 0.0043 0.6231491411777261 0.0001807796202790417 0.0043 +exclude_inferred_synchronous_pair interface_edge_fraction 31 31 31 8 -0.02800013638762627 0.008275397246231442 0.0007155782117498351 3.752303522932706e-05 0.0003 -0.6078291955142205 0.00028686309430395125 0.0006666666666666666 +exclude_all_multicomponent_biopsies locked_fraction 26 26 25 8 0.04013290361578649 0.008069357255321291 6.575665346121842e-07 1.4283275422853337e-10 0.0001 0.743321060134342 1.3572958750581133e-05 0.0002 +exclude_all_multicomponent_biopsies largest_locked_domain_fraction 26 26 25 8 0.10745585881205949 0.029128186542153416 0.00022507712306421226 5.490827270190565e-07 0.0002 0.8094878969266034 5.500831103452181e-07 0.0002666666666666667 +exclude_all_multicomponent_biopsies locked_domain_coherence 26 26 25 8 0.10933636964171264 0.03883848266938813 0.004875363113472985 0.00016495730642388944 0.0006 0.7813317961639389 2.4588243581773714e-06 0.0006 +exclude_all_multicomponent_biopsies interface_edge_fraction 26 26 25 8 -0.03358168150339014 0.008841564903422475 0.00014577399390420284 2.010945908400011e-06 0.0001 -0.6989752014331453 7.115778334351193e-05 0.0002 diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_scenario_topology.tsv b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_scenario_topology.tsv new file mode 100644 index 0000000..d115371 --- /dev/null +++ b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_mapping_scenario_topology.tsv @@ -0,0 +1,210 @@ +scenario analysis_unit biopsy_id component array patient_cluster stage_numeric n_spots locked_fraction largest_locked_domain_fraction locked_domain_coherence interface_edge_fraction n_graph_edges +registered_biopsy_all UQ_B02 UQ_B02 MULTI VLP115_A UQ_P02 1.0 709 0.6516220028208745 0.5909732016925247 0.9069264069264069 0.45194805194805193 1925 +registered_biopsy_all UQ_B01 UQ_B01 C1 VLP115_A UQ_P01 3.0 351 0.7065527065527065 0.6923076923076923 0.9798387096774194 0.37852494577006507 922 +registered_biopsy_all UQ_B04 UQ_B04 C6 VLP115_A UQ_P04 1.0 423 0.6193853427895981 0.524822695035461 0.8473282442748091 0.4395017793594306 1124 +registered_biopsy_all UQ_B03 UQ_B03 MULTI VLP115_A UQ_P03 1.0 260 0.6730769230769231 0.45384615384615384 0.6742857142857143 0.4270516717325228 658 +registered_biopsy_all UQ_B07 UQ_B07 C4 VLP116_D UQ_P07 4.0 838 0.779236276849642 0.7565632458233891 0.9709035222052067 0.3270547945205479 2336 +registered_biopsy_all UQ_B06 UQ_B06 MULTI VLP116_D UQ_P06 3.0 197 0.7055837563451777 0.6192893401015228 0.8776978417266187 0.4222222222222222 495 +registered_biopsy_all UQ_B05 UQ_B05 C1 VLP116_D UQ_P05 3.0 514 0.6945525291828794 0.49416342412451364 0.711484593837535 0.39222873900293254 1364 +registered_biopsy_all UQ_B08 UQ_B08 C5 VLP116_D UQ_P08 0.0 624 0.6698717948717948 0.6426282051282052 0.9593301435406698 0.41607981220657275 1704 +registered_biopsy_all UQ_B10 UQ_B10 C2 VLP119_A UQ_P10 3.0 444 0.7927927927927928 0.7792792792792793 0.9829545454545454 0.3197573656845754 1154 +registered_biopsy_all UQ_B09 UQ_B09 C1 VLP119_A UQ_P09 1.0 232 0.6853448275862069 0.47413793103448276 0.6918238993710691 0.4209558823529412 544 +registered_biopsy_all UQ_B12 UQ_B12 C7 VLP119_A UQ_P12 1.0 631 0.6608557844690967 0.410459587955626 0.6211031175059952 0.42166569598136283 1717 +registered_biopsy_all UQ_B11 UQ_B11 MULTI VLP119_A UQ_P11 2.0 384 0.640625 0.22135416666666666 0.34552845528455284 0.4349726775956284 915 +registered_biopsy_all UQ_B14 UQ_B14 C2 VLP119_D UQ_P14 1.0 394 0.616751269035533 0.1751269035532995 0.2839506172839506 0.46310679611650485 1030 +registered_biopsy_all UQ_B13 UQ_B13 C1 VLP119_D UQ_P13 4.0 190 0.7842105263157895 0.7526315789473684 0.959731543624161 0.2914046121593291 477 +registered_biopsy_all UQ_B16 UQ_B16 MULTI VLP119_D UQ_P16 1.0 508 0.7677165354330708 0.3937007874015748 0.5128205128205128 0.36106623586429726 1238 +registered_biopsy_all UQ_B15 UQ_B15 C3 VLP119_D UQ_P15 1.0 163 0.5950920245398773 0.2883435582822086 0.4845360824742268 0.47680412371134023 388 +registered_biopsy_all UQ_B19 UQ_B19 C4 VLP120_A UQ_P19 3.0 575 0.6539130434782608 0.6278260869565218 0.9601063829787234 0.4381510416666667 1536 +registered_biopsy_all UQ_B18 UQ_B18 C3 VLP120_A UQ_P18 0.0 421 0.5914489311163895 0.28978622327790976 0.4899598393574297 0.48080438756855576 1094 +registered_biopsy_all UQ_B17 UQ_B17 MULTI VLP120_A UQ_P17 0.0 306 0.7091503267973857 0.4084967320261438 0.576036866359447 0.4066666666666667 750 +registered_biopsy_all UQ_B20 UQ_B20 C5 VLP120_A UQ_P20 4.0 582 0.7869415807560137 0.7835051546391752 0.9956331877729258 0.3146853146853147 1573 +registered_biopsy_all UQ_B23 UQ_B23 C3 VLP120_D UQ_P23 2.0 620 0.714516129032258 0.41451612903225804 0.5801354401805869 0.36808009422850413 1698 +registered_biopsy_all UQ_B22 UQ_B22 C2 VLP120_D UQ_SYNC 3.0 339 0.7433628318584071 0.7345132743362832 0.9880952380952381 0.3010033444816054 897 +registered_biopsy_all UQ_B24 UQ_B24 C4 VLP120_D UQ_P24 1.0 608 0.680921052631579 0.3404605263157895 0.5 0.4434416365824308 1662 +registered_biopsy_all UQ_B21 UQ_B21 C1 VLP120_D UQ_SYNC 3.0 83 0.7469879518072289 0.6987951807228916 0.9354838709677419 0.37373737373737376 198 +registered_biopsy_all UQ_B27 UQ_B27 C3 VLP121_A UQ_P27 4.0 590 0.676271186440678 0.6610169491525424 0.9774436090225563 0.41838649155722324 1599 +registered_biopsy_all UQ_B26 UQ_B26 C2 VLP121_A UQ_P26 4.0 465 0.7913978494623656 0.7870967741935484 0.9945652173913043 0.3156225218080888 1261 +registered_biopsy_all UQ_B25 UQ_B25 C1 VLP121_A UQ_P25 2.0 334 0.5658682634730539 0.5 0.8835978835978836 0.4771689497716895 876 +registered_biopsy_all UQ_B28 UQ_B28 MULTI VLP121_A UQ_P28 4.0 117 0.6837606837606838 0.26495726495726496 0.3875 0.3886792452830189 265 +registered_biopsy_all UQ_B30 UQ_B30 C2 VLP121_D UQ_P30 0.0 405 0.6370370370370371 0.24444444444444444 0.38372093023255816 0.4234647112740605 1091 +registered_biopsy_all UQ_B29 UQ_B29 C1 VLP121_D UQ_P29 4.0 361 0.7091412742382271 0.7091412742382271 1.0 0.4224049331963001 973 +registered_biopsy_all UQ_B33 UQ_B33 C5 VLP121_D UQ_P33 3.0 444 0.7477477477477478 0.7364864864864865 0.9849397590361446 0.35175879396984927 1194 +registered_biopsy_all UQ_B32 UQ_B32 C4 VLP121_D UQ_P32 3.0 284 0.7464788732394366 0.7288732394366197 0.9764150943396226 0.3724966622162884 749 +registered_biopsy_all UQ_B31 UQ_B31 C3 VLP121_D UQ_P31 0.0 189 0.6084656084656085 0.4708994708994709 0.7739130434782608 0.502127659574468 470 +registered_biopsy_no_fragment_rescue UQ_B02 UQ_B02 MULTI VLP115_A UQ_P02 1.0 694 0.6498559077809798 0.6037463976945245 0.9290465631929047 0.4528202424881392 1897 +registered_biopsy_no_fragment_rescue UQ_B01 UQ_B01 C1 VLP115_A UQ_P01 3.0 351 0.7065527065527065 0.6923076923076923 0.9798387096774194 0.37852494577006507 922 +registered_biopsy_no_fragment_rescue UQ_B04 UQ_B04 C6 VLP115_A UQ_P04 1.0 423 0.6193853427895981 0.524822695035461 0.8473282442748091 0.4395017793594306 1124 +registered_biopsy_no_fragment_rescue UQ_B03 UQ_B03 MULTI VLP115_A UQ_P03 1.0 260 0.6730769230769231 0.45384615384615384 0.6742857142857143 0.4270516717325228 658 +registered_biopsy_no_fragment_rescue UQ_B07 UQ_B07 C4 VLP116_D UQ_P07 4.0 838 0.779236276849642 0.7565632458233891 0.9709035222052067 0.3270547945205479 2336 +registered_biopsy_no_fragment_rescue UQ_B06 UQ_B06 MULTI VLP116_D UQ_P06 3.0 197 0.7055837563451777 0.6192893401015228 0.8776978417266187 0.4222222222222222 495 +registered_biopsy_no_fragment_rescue UQ_B05 UQ_B05 C1 VLP116_D UQ_P05 3.0 514 0.6945525291828794 0.49416342412451364 0.711484593837535 0.39222873900293254 1364 +registered_biopsy_no_fragment_rescue UQ_B08 UQ_B08 C5 VLP116_D UQ_P08 0.0 624 0.6698717948717948 0.6426282051282052 0.9593301435406698 0.41607981220657275 1704 +registered_biopsy_no_fragment_rescue UQ_B10 UQ_B10 C2 VLP119_A UQ_P10 3.0 444 0.7927927927927928 0.7792792792792793 0.9829545454545454 0.3197573656845754 1154 +registered_biopsy_no_fragment_rescue UQ_B09 UQ_B09 C1 VLP119_A UQ_P09 1.0 232 0.6853448275862069 0.47413793103448276 0.6918238993710691 0.4209558823529412 544 +registered_biopsy_no_fragment_rescue UQ_B12 UQ_B12 C7 VLP119_A UQ_P12 1.0 631 0.6608557844690967 0.410459587955626 0.6211031175059952 0.42166569598136283 1717 +registered_biopsy_no_fragment_rescue UQ_B11 UQ_B11 MULTI VLP119_A UQ_P11 2.0 378 0.6428571428571429 0.22486772486772486 0.3497942386831276 0.43530701754385964 912 +registered_biopsy_no_fragment_rescue UQ_B14 UQ_B14 C2 VLP119_D UQ_P14 1.0 390 0.6205128205128205 0.17692307692307693 0.28512396694214875 0.4619883040935672 1026 +registered_biopsy_no_fragment_rescue UQ_B13 UQ_B13 C1 VLP119_D UQ_P13 4.0 184 0.7771739130434783 0.7771739130434783 1.0 0.297008547008547 468 +registered_biopsy_no_fragment_rescue UQ_B16 UQ_B16 MULTI VLP119_D UQ_P16 1.0 508 0.7677165354330708 0.3937007874015748 0.5128205128205128 0.36106623586429726 1238 +registered_biopsy_no_fragment_rescue UQ_B15 UQ_B15 C3 VLP119_D UQ_P15 1.0 163 0.5950920245398773 0.2883435582822086 0.4845360824742268 0.47680412371134023 388 +registered_biopsy_no_fragment_rescue UQ_B19 UQ_B19 C4 VLP120_A UQ_P19 3.0 575 0.6539130434782608 0.6278260869565218 0.9601063829787234 0.4381510416666667 1536 +registered_biopsy_no_fragment_rescue UQ_B18 UQ_B18 C3 VLP120_A UQ_P18 0.0 421 0.5914489311163895 0.28978622327790976 0.4899598393574297 0.48080438756855576 1094 +registered_biopsy_no_fragment_rescue UQ_B17 UQ_B17 MULTI VLP120_A UQ_P17 0.0 300 0.7166666666666667 0.4166666666666667 0.5813953488372093 0.4061662198391421 746 +registered_biopsy_no_fragment_rescue UQ_B20 UQ_B20 C5 VLP120_A UQ_P20 4.0 582 0.7869415807560137 0.7835051546391752 0.9956331877729258 0.3146853146853147 1573 +registered_biopsy_no_fragment_rescue UQ_B23 UQ_B23 C3 VLP120_D UQ_P23 2.0 620 0.714516129032258 0.41451612903225804 0.5801354401805869 0.36808009422850413 1698 +registered_biopsy_no_fragment_rescue UQ_B22 UQ_B22 C2 VLP120_D UQ_SYNC 3.0 339 0.7433628318584071 0.7345132743362832 0.9880952380952381 0.3010033444816054 897 +registered_biopsy_no_fragment_rescue UQ_B24 UQ_B24 C4 VLP120_D UQ_P24 1.0 608 0.680921052631579 0.3404605263157895 0.5 0.4434416365824308 1662 +registered_biopsy_no_fragment_rescue UQ_B21 UQ_B21 C1 VLP120_D UQ_SYNC 3.0 79 0.7468354430379747 0.7341772151898734 0.9830508474576272 0.37305699481865284 193 +registered_biopsy_no_fragment_rescue UQ_B27 UQ_B27 C3 VLP121_A UQ_P27 4.0 590 0.676271186440678 0.6610169491525424 0.9774436090225563 0.41838649155722324 1599 +registered_biopsy_no_fragment_rescue UQ_B26 UQ_B26 C2 VLP121_A UQ_P26 4.0 465 0.7913978494623656 0.7870967741935484 0.9945652173913043 0.3156225218080888 1261 +registered_biopsy_no_fragment_rescue UQ_B25 UQ_B25 C1 VLP121_A UQ_P25 2.0 334 0.5658682634730539 0.5 0.8835978835978836 0.4771689497716895 876 +registered_biopsy_no_fragment_rescue UQ_B28 UQ_B28 MULTI VLP121_A UQ_P28 4.0 112 0.6696428571428571 0.2767857142857143 0.41333333333333333 0.39615384615384613 260 +registered_biopsy_no_fragment_rescue UQ_B30 UQ_B30 C2 VLP121_D UQ_P30 0.0 405 0.6370370370370371 0.24444444444444444 0.38372093023255816 0.4234647112740605 1091 +registered_biopsy_no_fragment_rescue UQ_B29 UQ_B29 C1 VLP121_D UQ_P29 4.0 361 0.7091412742382271 0.7091412742382271 1.0 0.4224049331963001 973 +registered_biopsy_no_fragment_rescue UQ_B33 UQ_B33 C5 VLP121_D UQ_P33 3.0 444 0.7477477477477478 0.7364864864864865 0.9849397590361446 0.35175879396984927 1194 +registered_biopsy_no_fragment_rescue UQ_B32 UQ_B32 C4 VLP121_D UQ_P32 3.0 284 0.7464788732394366 0.7288732394366197 0.9764150943396226 0.3724966622162884 749 +registered_biopsy_no_fragment_rescue UQ_B31 UQ_B31 C3 VLP121_D UQ_P31 0.0 189 0.6084656084656085 0.4708994708994709 0.7739130434782608 0.502127659574468 470 +geometry_component_split_all VLP115_A_C2 UQ_B02 C2 VLP115_A UQ_P02 1.0 684 0.652046783625731 0.6125730994152047 0.9394618834080718 0.45285029302077784 1877 +geometry_component_split_all VLP115_A_C3 UQ_B02 C3 VLP115_A UQ_P02 1.0 25 0.64 0.4 0.625 0.4166666666666667 48 +geometry_component_split_all VLP115_A_C1 UQ_B01 C1 VLP115_A UQ_P01 3.0 351 0.7065527065527065 0.6923076923076923 0.9798387096774194 0.37852494577006507 922 +geometry_component_split_all VLP115_A_C6 UQ_B04 C6 VLP115_A UQ_P04 1.0 423 0.6193853427895981 0.524822695035461 0.8473282442748091 0.4395017793594306 1124 +geometry_component_split_all VLP115_A_C4 UQ_B03 C4 VLP115_A UQ_P03 1.0 190 0.6631578947368421 0.6210526315789474 0.9365079365079365 0.432712215320911 483 +geometry_component_split_all VLP115_A_C5 UQ_B03 C5 VLP115_A UQ_P03 1.0 70 0.7 0.7 1.0 0.4114285714285714 175 +geometry_component_split_all VLP116_D_C4 UQ_B07 C4 VLP116_D UQ_P07 4.0 838 0.779236276849642 0.7565632458233891 0.9709035222052067 0.3270547945205479 2336 +geometry_component_split_all VLP116_D_C3 UQ_B06 C3 VLP116_D UQ_P06 3.0 168 0.7261904761904762 0.7261904761904762 1.0 0.4004524886877828 442 +geometry_component_split_all VLP116_D_C2 UQ_B06 C2 VLP116_D UQ_P06 3.0 29 0.5862068965517241 0.2413793103448276 0.4117647058823529 0.6037735849056604 53 +geometry_component_split_all VLP116_D_C1 UQ_B05 C1 VLP116_D UQ_P05 3.0 514 0.6945525291828794 0.49416342412451364 0.711484593837535 0.39222873900293254 1364 +geometry_component_split_all VLP116_D_C5 UQ_B08 C5 VLP116_D UQ_P08 0.0 624 0.6698717948717948 0.6426282051282052 0.9593301435406698 0.41607981220657275 1704 +geometry_component_split_all VLP119_A_C2 UQ_B10 C2 VLP119_A UQ_P10 3.0 444 0.7927927927927928 0.7792792792792793 0.9829545454545454 0.3197573656845754 1154 +geometry_component_split_all VLP119_A_C1 UQ_B09 C1 VLP119_A UQ_P09 1.0 232 0.6853448275862069 0.47413793103448276 0.6918238993710691 0.4209558823529412 544 +geometry_component_split_all VLP119_A_C7 UQ_B12 C7 VLP119_A UQ_P12 1.0 631 0.6608557844690967 0.410459587955626 0.6211031175059952 0.42166569598136283 1717 +geometry_component_split_all VLP119_A_C3 UQ_B11 C3 VLP119_A UQ_P11 2.0 97 0.5876288659793815 0.36082474226804123 0.6140350877192983 0.47580645161290325 248 +geometry_component_split_all VLP119_A_C6 UQ_B11 C6 VLP119_A UQ_P11 2.0 58 0.6379310344827587 0.27586206896551724 0.43243243243243246 0.4188034188034188 117 +geometry_component_split_all VLP119_A_C4 UQ_B11 C4 VLP119_A UQ_P11 2.0 206 0.6650485436893204 0.41262135922330095 0.6204379562043796 0.4207436399217221 511 +geometry_component_split_all VLP119_A_C5 UQ_B11 C5 VLP119_A UQ_P11 2.0 23 0.6521739130434783 0.6086956521739131 0.9333333333333333 0.39473684210526316 38 +geometry_component_split_all VLP119_D_C2 UQ_B14 C2 VLP119_D UQ_P14 1.0 394 0.616751269035533 0.1751269035532995 0.2839506172839506 0.46310679611650485 1030 +geometry_component_split_all VLP119_D_C1 UQ_B13 C1 VLP119_D UQ_P13 4.0 190 0.7842105263157895 0.7526315789473684 0.959731543624161 0.2914046121593291 477 +geometry_component_split_all VLP119_D_C6 UQ_B16 C6 VLP119_D UQ_P16 1.0 198 0.7323232323232324 0.3383838383838384 0.46206896551724136 0.40987124463519314 466 +geometry_component_split_all VLP119_D_C4 UQ_B16 C4 VLP119_D UQ_P16 1.0 21 0.9047619047619048 0.9047619047619048 1.0 0.10869565217391304 46 +geometry_component_split_all VLP119_D_C5 UQ_B16 C5 VLP119_D UQ_P16 1.0 289 0.7820069204152249 0.6920415224913494 0.8849557522123894 0.34573002754820936 726 +geometry_component_split_all VLP119_D_C3 UQ_B15 C3 VLP119_D UQ_P15 1.0 163 0.5950920245398773 0.2883435582822086 0.4845360824742268 0.47680412371134023 388 +geometry_component_split_all VLP120_A_C4 UQ_B19 C4 VLP120_A UQ_P19 3.0 575 0.6539130434782608 0.6278260869565218 0.9601063829787234 0.4381510416666667 1536 +geometry_component_split_all VLP120_A_C3 UQ_B18 C3 VLP120_A UQ_P18 0.0 421 0.5914489311163895 0.28978622327790976 0.4899598393574297 0.48080438756855576 1094 +geometry_component_split_all VLP120_A_C1 UQ_B17 C1 VLP120_A UQ_P17 0.0 107 0.7383177570093458 0.7383177570093458 1.0 0.37593984962406013 266 +geometry_component_split_all VLP120_A_C2 UQ_B17 C2 VLP120_A UQ_P17 0.0 199 0.6934673366834171 0.628140703517588 0.9057971014492754 0.42355371900826444 484 +geometry_component_split_all VLP120_A_C5 UQ_B20 C5 VLP120_A UQ_P20 4.0 582 0.7869415807560137 0.7835051546391752 0.9956331877729258 0.3146853146853147 1573 +geometry_component_split_all VLP120_D_C3 UQ_B23 C3 VLP120_D UQ_P23 2.0 620 0.714516129032258 0.41451612903225804 0.5801354401805869 0.36808009422850413 1698 +geometry_component_split_all VLP120_D_C2 UQ_B22 C2 VLP120_D UQ_SYNC 3.0 339 0.7433628318584071 0.7345132743362832 0.9880952380952381 0.3010033444816054 897 +geometry_component_split_all VLP120_D_C4 UQ_B24 C4 VLP120_D UQ_P24 1.0 608 0.680921052631579 0.3404605263157895 0.5 0.4434416365824308 1662 +geometry_component_split_all VLP120_D_C1 UQ_B21 C1 VLP120_D UQ_SYNC 3.0 83 0.7469879518072289 0.6987951807228916 0.9354838709677419 0.37373737373737376 198 +geometry_component_split_all VLP121_A_C3 UQ_B27 C3 VLP121_A UQ_P27 4.0 590 0.676271186440678 0.6610169491525424 0.9774436090225563 0.41838649155722324 1599 +geometry_component_split_all VLP121_A_C2 UQ_B26 C2 VLP121_A UQ_P26 4.0 465 0.7913978494623656 0.7870967741935484 0.9945652173913043 0.3156225218080888 1261 +geometry_component_split_all VLP121_A_C1 UQ_B25 C1 VLP121_A UQ_P25 2.0 334 0.5658682634730539 0.5 0.8835978835978836 0.4771689497716895 876 +geometry_component_split_all VLP121_A_C5 UQ_B28 C5 VLP121_A UQ_P28 4.0 29 0.7931034482758621 0.5517241379310345 0.6956521739130435 0.21428571428571427 56 +geometry_component_split_all VLP121_A_C4 UQ_B28 C4 VLP121_A UQ_P28 4.0 88 0.6477272727272727 0.3522727272727273 0.543859649122807 0.4354066985645933 209 +geometry_component_split_all VLP121_D_C2 UQ_B30 C2 VLP121_D UQ_P30 0.0 405 0.6370370370370371 0.24444444444444444 0.38372093023255816 0.4234647112740605 1091 +geometry_component_split_all VLP121_D_C1 UQ_B29 C1 VLP121_D UQ_P29 4.0 361 0.7091412742382271 0.7091412742382271 1.0 0.4224049331963001 973 +geometry_component_split_all VLP121_D_C5 UQ_B33 C5 VLP121_D UQ_P33 3.0 444 0.7477477477477478 0.7364864864864865 0.9849397590361446 0.35175879396984927 1194 +geometry_component_split_all VLP121_D_C4 UQ_B32 C4 VLP121_D UQ_P32 3.0 284 0.7464788732394366 0.7288732394366197 0.9764150943396226 0.3724966622162884 749 +geometry_component_split_all VLP121_D_C3 UQ_B31 C3 VLP121_D UQ_P31 0.0 189 0.6084656084656085 0.4708994708994709 0.7739130434782608 0.502127659574468 470 +geometry_component_split_no_fragment_rescue VLP115_A_C2 UQ_B02 C2 VLP115_A UQ_P02 1.0 670 0.6507462686567164 0.6253731343283582 0.9610091743119266 0.45375878853434287 1849 +geometry_component_split_no_fragment_rescue VLP115_A_C3 UQ_B02 C3 VLP115_A UQ_P02 1.0 24 0.625 0.4166666666666667 0.6666666666666666 0.4166666666666667 48 +geometry_component_split_no_fragment_rescue VLP115_A_C1 UQ_B01 C1 VLP115_A UQ_P01 3.0 351 0.7065527065527065 0.6923076923076923 0.9798387096774194 0.37852494577006507 922 +geometry_component_split_no_fragment_rescue VLP115_A_C6 UQ_B04 C6 VLP115_A UQ_P04 1.0 423 0.6193853427895981 0.524822695035461 0.8473282442748091 0.4395017793594306 1124 +geometry_component_split_no_fragment_rescue VLP115_A_C4 UQ_B03 C4 VLP115_A UQ_P03 1.0 190 0.6631578947368421 0.6210526315789474 0.9365079365079365 0.432712215320911 483 +geometry_component_split_no_fragment_rescue VLP115_A_C5 UQ_B03 C5 VLP115_A UQ_P03 1.0 70 0.7 0.7 1.0 0.4114285714285714 175 +geometry_component_split_no_fragment_rescue VLP116_D_C4 UQ_B07 C4 VLP116_D UQ_P07 4.0 838 0.779236276849642 0.7565632458233891 0.9709035222052067 0.3270547945205479 2336 +geometry_component_split_no_fragment_rescue VLP116_D_C3 UQ_B06 C3 VLP116_D UQ_P06 3.0 168 0.7261904761904762 0.7261904761904762 1.0 0.4004524886877828 442 +geometry_component_split_no_fragment_rescue VLP116_D_C2 UQ_B06 C2 VLP116_D UQ_P06 3.0 29 0.5862068965517241 0.2413793103448276 0.4117647058823529 0.6037735849056604 53 +geometry_component_split_no_fragment_rescue VLP116_D_C1 UQ_B05 C1 VLP116_D UQ_P05 3.0 514 0.6945525291828794 0.49416342412451364 0.711484593837535 0.39222873900293254 1364 +geometry_component_split_no_fragment_rescue VLP116_D_C5 UQ_B08 C5 VLP116_D UQ_P08 0.0 624 0.6698717948717948 0.6426282051282052 0.9593301435406698 0.41607981220657275 1704 +geometry_component_split_no_fragment_rescue VLP119_A_C2 UQ_B10 C2 VLP119_A UQ_P10 3.0 444 0.7927927927927928 0.7792792792792793 0.9829545454545454 0.3197573656845754 1154 +geometry_component_split_no_fragment_rescue VLP119_A_C1 UQ_B09 C1 VLP119_A UQ_P09 1.0 232 0.6853448275862069 0.47413793103448276 0.6918238993710691 0.4209558823529412 544 +geometry_component_split_no_fragment_rescue VLP119_A_C7 UQ_B12 C7 VLP119_A UQ_P12 1.0 631 0.6608557844690967 0.410459587955626 0.6211031175059952 0.42166569598136283 1717 +geometry_component_split_no_fragment_rescue VLP119_A_C3 UQ_B11 C3 VLP119_A UQ_P11 2.0 97 0.5876288659793815 0.36082474226804123 0.6140350877192983 0.47580645161290325 248 +geometry_component_split_no_fragment_rescue VLP119_A_C6 UQ_B11 C6 VLP119_A UQ_P11 2.0 56 0.6607142857142857 0.2857142857142857 0.43243243243243246 0.4224137931034483 116 +geometry_component_split_no_fragment_rescue VLP119_A_C4 UQ_B11 C4 VLP119_A UQ_P11 2.0 203 0.6600985221674877 0.4187192118226601 0.6343283582089553 0.4215686274509804 510 +geometry_component_split_no_fragment_rescue VLP119_A_C5 UQ_B11 C5 VLP119_A UQ_P11 2.0 22 0.6818181818181818 0.6363636363636364 0.9333333333333333 0.39473684210526316 38 +geometry_component_split_no_fragment_rescue VLP119_D_C2 UQ_B14 C2 VLP119_D UQ_P14 1.0 390 0.6205128205128205 0.17692307692307693 0.28512396694214875 0.4619883040935672 1026 +geometry_component_split_no_fragment_rescue VLP119_D_C1 UQ_B13 C1 VLP119_D UQ_P13 4.0 184 0.7771739130434783 0.7771739130434783 1.0 0.297008547008547 468 +geometry_component_split_no_fragment_rescue VLP119_D_C6 UQ_B16 C6 VLP119_D UQ_P16 1.0 198 0.7323232323232324 0.3383838383838384 0.46206896551724136 0.40987124463519314 466 +geometry_component_split_no_fragment_rescue VLP119_D_C4 UQ_B16 C4 VLP119_D UQ_P16 1.0 21 0.9047619047619048 0.9047619047619048 1.0 0.10869565217391304 46 +geometry_component_split_no_fragment_rescue VLP119_D_C5 UQ_B16 C5 VLP119_D UQ_P16 1.0 289 0.7820069204152249 0.6920415224913494 0.8849557522123894 0.34573002754820936 726 +geometry_component_split_no_fragment_rescue VLP119_D_C3 UQ_B15 C3 VLP119_D UQ_P15 1.0 163 0.5950920245398773 0.2883435582822086 0.4845360824742268 0.47680412371134023 388 +geometry_component_split_no_fragment_rescue VLP120_A_C4 UQ_B19 C4 VLP120_A UQ_P19 3.0 575 0.6539130434782608 0.6278260869565218 0.9601063829787234 0.4381510416666667 1536 +geometry_component_split_no_fragment_rescue VLP120_A_C3 UQ_B18 C3 VLP120_A UQ_P18 0.0 421 0.5914489311163895 0.28978622327790976 0.4899598393574297 0.48080438756855576 1094 +geometry_component_split_no_fragment_rescue VLP120_A_C1 UQ_B17 C1 VLP120_A UQ_P17 0.0 107 0.7383177570093458 0.7383177570093458 1.0 0.37593984962406013 266 +geometry_component_split_no_fragment_rescue VLP120_A_C2 UQ_B17 C2 VLP120_A UQ_P17 0.0 193 0.7046632124352331 0.6476683937823834 0.9191176470588235 0.42291666666666666 480 +geometry_component_split_no_fragment_rescue VLP120_A_C5 UQ_B20 C5 VLP120_A UQ_P20 4.0 582 0.7869415807560137 0.7835051546391752 0.9956331877729258 0.3146853146853147 1573 +geometry_component_split_no_fragment_rescue VLP120_D_C3 UQ_B23 C3 VLP120_D UQ_P23 2.0 620 0.714516129032258 0.41451612903225804 0.5801354401805869 0.36808009422850413 1698 +geometry_component_split_no_fragment_rescue VLP120_D_C2 UQ_B22 C2 VLP120_D UQ_SYNC 3.0 339 0.7433628318584071 0.7345132743362832 0.9880952380952381 0.3010033444816054 897 +geometry_component_split_no_fragment_rescue VLP120_D_C4 UQ_B24 C4 VLP120_D UQ_P24 1.0 608 0.680921052631579 0.3404605263157895 0.5 0.4434416365824308 1662 +geometry_component_split_no_fragment_rescue VLP120_D_C1 UQ_B21 C1 VLP120_D UQ_SYNC 3.0 79 0.7468354430379747 0.7341772151898734 0.9830508474576272 0.37305699481865284 193 +geometry_component_split_no_fragment_rescue VLP121_A_C3 UQ_B27 C3 VLP121_A UQ_P27 4.0 590 0.676271186440678 0.6610169491525424 0.9774436090225563 0.41838649155722324 1599 +geometry_component_split_no_fragment_rescue VLP121_A_C2 UQ_B26 C2 VLP121_A UQ_P26 4.0 465 0.7913978494623656 0.7870967741935484 0.9945652173913043 0.3156225218080888 1261 +geometry_component_split_no_fragment_rescue VLP121_A_C1 UQ_B25 C1 VLP121_A UQ_P25 2.0 334 0.5658682634730539 0.5 0.8835978835978836 0.4771689497716895 876 +geometry_component_split_no_fragment_rescue VLP121_A_C5 UQ_B28 C5 VLP121_A UQ_P28 4.0 24 0.75 0.6666666666666666 0.8888888888888888 0.23529411764705882 51 +geometry_component_split_no_fragment_rescue VLP121_A_C4 UQ_B28 C4 VLP121_A UQ_P28 4.0 88 0.6477272727272727 0.3522727272727273 0.543859649122807 0.4354066985645933 209 +geometry_component_split_no_fragment_rescue VLP121_D_C2 UQ_B30 C2 VLP121_D UQ_P30 0.0 405 0.6370370370370371 0.24444444444444444 0.38372093023255816 0.4234647112740605 1091 +geometry_component_split_no_fragment_rescue VLP121_D_C1 UQ_B29 C1 VLP121_D UQ_P29 4.0 361 0.7091412742382271 0.7091412742382271 1.0 0.4224049331963001 973 +geometry_component_split_no_fragment_rescue VLP121_D_C5 UQ_B33 C5 VLP121_D UQ_P33 3.0 444 0.7477477477477478 0.7364864864864865 0.9849397590361446 0.35175879396984927 1194 +geometry_component_split_no_fragment_rescue VLP121_D_C4 UQ_B32 C4 VLP121_D UQ_P32 3.0 284 0.7464788732394366 0.7288732394366197 0.9764150943396226 0.3724966622162884 749 +geometry_component_split_no_fragment_rescue VLP121_D_C3 UQ_B31 C3 VLP121_D UQ_P31 0.0 189 0.6084656084656085 0.4708994708994709 0.7739130434782608 0.502127659574468 470 +exclude_inferred_synchronous_pair UQ_B02 UQ_B02 MULTI VLP115_A UQ_P02 1.0 709 0.6516220028208745 0.5909732016925247 0.9069264069264069 0.45194805194805193 1925 +exclude_inferred_synchronous_pair UQ_B01 UQ_B01 C1 VLP115_A UQ_P01 3.0 351 0.7065527065527065 0.6923076923076923 0.9798387096774194 0.37852494577006507 922 +exclude_inferred_synchronous_pair UQ_B04 UQ_B04 C6 VLP115_A UQ_P04 1.0 423 0.6193853427895981 0.524822695035461 0.8473282442748091 0.4395017793594306 1124 +exclude_inferred_synchronous_pair UQ_B03 UQ_B03 MULTI VLP115_A UQ_P03 1.0 260 0.6730769230769231 0.45384615384615384 0.6742857142857143 0.4270516717325228 658 +exclude_inferred_synchronous_pair UQ_B07 UQ_B07 C4 VLP116_D UQ_P07 4.0 838 0.779236276849642 0.7565632458233891 0.9709035222052067 0.3270547945205479 2336 +exclude_inferred_synchronous_pair UQ_B06 UQ_B06 MULTI VLP116_D UQ_P06 3.0 197 0.7055837563451777 0.6192893401015228 0.8776978417266187 0.4222222222222222 495 +exclude_inferred_synchronous_pair UQ_B05 UQ_B05 C1 VLP116_D UQ_P05 3.0 514 0.6945525291828794 0.49416342412451364 0.711484593837535 0.39222873900293254 1364 +exclude_inferred_synchronous_pair UQ_B08 UQ_B08 C5 VLP116_D UQ_P08 0.0 624 0.6698717948717948 0.6426282051282052 0.9593301435406698 0.41607981220657275 1704 +exclude_inferred_synchronous_pair UQ_B10 UQ_B10 C2 VLP119_A UQ_P10 3.0 444 0.7927927927927928 0.7792792792792793 0.9829545454545454 0.3197573656845754 1154 +exclude_inferred_synchronous_pair UQ_B09 UQ_B09 C1 VLP119_A UQ_P09 1.0 232 0.6853448275862069 0.47413793103448276 0.6918238993710691 0.4209558823529412 544 +exclude_inferred_synchronous_pair UQ_B12 UQ_B12 C7 VLP119_A UQ_P12 1.0 631 0.6608557844690967 0.410459587955626 0.6211031175059952 0.42166569598136283 1717 +exclude_inferred_synchronous_pair UQ_B11 UQ_B11 MULTI VLP119_A UQ_P11 2.0 384 0.640625 0.22135416666666666 0.34552845528455284 0.4349726775956284 915 +exclude_inferred_synchronous_pair UQ_B14 UQ_B14 C2 VLP119_D UQ_P14 1.0 394 0.616751269035533 0.1751269035532995 0.2839506172839506 0.46310679611650485 1030 +exclude_inferred_synchronous_pair UQ_B13 UQ_B13 C1 VLP119_D UQ_P13 4.0 190 0.7842105263157895 0.7526315789473684 0.959731543624161 0.2914046121593291 477 +exclude_inferred_synchronous_pair UQ_B16 UQ_B16 MULTI VLP119_D UQ_P16 1.0 508 0.7677165354330708 0.3937007874015748 0.5128205128205128 0.36106623586429726 1238 +exclude_inferred_synchronous_pair UQ_B15 UQ_B15 C3 VLP119_D UQ_P15 1.0 163 0.5950920245398773 0.2883435582822086 0.4845360824742268 0.47680412371134023 388 +exclude_inferred_synchronous_pair UQ_B19 UQ_B19 C4 VLP120_A UQ_P19 3.0 575 0.6539130434782608 0.6278260869565218 0.9601063829787234 0.4381510416666667 1536 +exclude_inferred_synchronous_pair UQ_B18 UQ_B18 C3 VLP120_A UQ_P18 0.0 421 0.5914489311163895 0.28978622327790976 0.4899598393574297 0.48080438756855576 1094 +exclude_inferred_synchronous_pair UQ_B17 UQ_B17 MULTI VLP120_A UQ_P17 0.0 306 0.7091503267973857 0.4084967320261438 0.576036866359447 0.4066666666666667 750 +exclude_inferred_synchronous_pair UQ_B20 UQ_B20 C5 VLP120_A UQ_P20 4.0 582 0.7869415807560137 0.7835051546391752 0.9956331877729258 0.3146853146853147 1573 +exclude_inferred_synchronous_pair UQ_B23 UQ_B23 C3 VLP120_D UQ_P23 2.0 620 0.714516129032258 0.41451612903225804 0.5801354401805869 0.36808009422850413 1698 +exclude_inferred_synchronous_pair UQ_B24 UQ_B24 C4 VLP120_D UQ_P24 1.0 608 0.680921052631579 0.3404605263157895 0.5 0.4434416365824308 1662 +exclude_inferred_synchronous_pair UQ_B27 UQ_B27 C3 VLP121_A UQ_P27 4.0 590 0.676271186440678 0.6610169491525424 0.9774436090225563 0.41838649155722324 1599 +exclude_inferred_synchronous_pair UQ_B26 UQ_B26 C2 VLP121_A UQ_P26 4.0 465 0.7913978494623656 0.7870967741935484 0.9945652173913043 0.3156225218080888 1261 +exclude_inferred_synchronous_pair UQ_B25 UQ_B25 C1 VLP121_A UQ_P25 2.0 334 0.5658682634730539 0.5 0.8835978835978836 0.4771689497716895 876 +exclude_inferred_synchronous_pair UQ_B28 UQ_B28 MULTI VLP121_A UQ_P28 4.0 117 0.6837606837606838 0.26495726495726496 0.3875 0.3886792452830189 265 +exclude_inferred_synchronous_pair UQ_B30 UQ_B30 C2 VLP121_D UQ_P30 0.0 405 0.6370370370370371 0.24444444444444444 0.38372093023255816 0.4234647112740605 1091 +exclude_inferred_synchronous_pair UQ_B29 UQ_B29 C1 VLP121_D UQ_P29 4.0 361 0.7091412742382271 0.7091412742382271 1.0 0.4224049331963001 973 +exclude_inferred_synchronous_pair UQ_B33 UQ_B33 C5 VLP121_D UQ_P33 3.0 444 0.7477477477477478 0.7364864864864865 0.9849397590361446 0.35175879396984927 1194 +exclude_inferred_synchronous_pair UQ_B32 UQ_B32 C4 VLP121_D UQ_P32 3.0 284 0.7464788732394366 0.7288732394366197 0.9764150943396226 0.3724966622162884 749 +exclude_inferred_synchronous_pair UQ_B31 UQ_B31 C3 VLP121_D UQ_P31 0.0 189 0.6084656084656085 0.4708994708994709 0.7739130434782608 0.502127659574468 470 +exclude_all_multicomponent_biopsies UQ_B01 UQ_B01 C1 VLP115_A UQ_P01 3.0 351 0.7065527065527065 0.6923076923076923 0.9798387096774194 0.37852494577006507 922 +exclude_all_multicomponent_biopsies UQ_B04 UQ_B04 C6 VLP115_A UQ_P04 1.0 423 0.6193853427895981 0.524822695035461 0.8473282442748091 0.4395017793594306 1124 +exclude_all_multicomponent_biopsies UQ_B07 UQ_B07 C4 VLP116_D UQ_P07 4.0 838 0.779236276849642 0.7565632458233891 0.9709035222052067 0.3270547945205479 2336 +exclude_all_multicomponent_biopsies UQ_B05 UQ_B05 C1 VLP116_D UQ_P05 3.0 514 0.6945525291828794 0.49416342412451364 0.711484593837535 0.39222873900293254 1364 +exclude_all_multicomponent_biopsies UQ_B08 UQ_B08 C5 VLP116_D UQ_P08 0.0 624 0.6698717948717948 0.6426282051282052 0.9593301435406698 0.41607981220657275 1704 +exclude_all_multicomponent_biopsies UQ_B10 UQ_B10 C2 VLP119_A UQ_P10 3.0 444 0.7927927927927928 0.7792792792792793 0.9829545454545454 0.3197573656845754 1154 +exclude_all_multicomponent_biopsies UQ_B09 UQ_B09 C1 VLP119_A UQ_P09 1.0 232 0.6853448275862069 0.47413793103448276 0.6918238993710691 0.4209558823529412 544 +exclude_all_multicomponent_biopsies UQ_B12 UQ_B12 C7 VLP119_A UQ_P12 1.0 631 0.6608557844690967 0.410459587955626 0.6211031175059952 0.42166569598136283 1717 +exclude_all_multicomponent_biopsies UQ_B14 UQ_B14 C2 VLP119_D UQ_P14 1.0 394 0.616751269035533 0.1751269035532995 0.2839506172839506 0.46310679611650485 1030 +exclude_all_multicomponent_biopsies UQ_B13 UQ_B13 C1 VLP119_D UQ_P13 4.0 190 0.7842105263157895 0.7526315789473684 0.959731543624161 0.2914046121593291 477 +exclude_all_multicomponent_biopsies UQ_B15 UQ_B15 C3 VLP119_D UQ_P15 1.0 163 0.5950920245398773 0.2883435582822086 0.4845360824742268 0.47680412371134023 388 +exclude_all_multicomponent_biopsies UQ_B19 UQ_B19 C4 VLP120_A UQ_P19 3.0 575 0.6539130434782608 0.6278260869565218 0.9601063829787234 0.4381510416666667 1536 +exclude_all_multicomponent_biopsies UQ_B18 UQ_B18 C3 VLP120_A UQ_P18 0.0 421 0.5914489311163895 0.28978622327790976 0.4899598393574297 0.48080438756855576 1094 +exclude_all_multicomponent_biopsies UQ_B20 UQ_B20 C5 VLP120_A UQ_P20 4.0 582 0.7869415807560137 0.7835051546391752 0.9956331877729258 0.3146853146853147 1573 +exclude_all_multicomponent_biopsies UQ_B23 UQ_B23 C3 VLP120_D UQ_P23 2.0 620 0.714516129032258 0.41451612903225804 0.5801354401805869 0.36808009422850413 1698 +exclude_all_multicomponent_biopsies UQ_B22 UQ_B22 C2 VLP120_D UQ_SYNC 3.0 339 0.7433628318584071 0.7345132743362832 0.9880952380952381 0.3010033444816054 897 +exclude_all_multicomponent_biopsies UQ_B24 UQ_B24 C4 VLP120_D UQ_P24 1.0 608 0.680921052631579 0.3404605263157895 0.5 0.4434416365824308 1662 +exclude_all_multicomponent_biopsies UQ_B21 UQ_B21 C1 VLP120_D UQ_SYNC 3.0 83 0.7469879518072289 0.6987951807228916 0.9354838709677419 0.37373737373737376 198 +exclude_all_multicomponent_biopsies UQ_B27 UQ_B27 C3 VLP121_A UQ_P27 4.0 590 0.676271186440678 0.6610169491525424 0.9774436090225563 0.41838649155722324 1599 +exclude_all_multicomponent_biopsies UQ_B26 UQ_B26 C2 VLP121_A UQ_P26 4.0 465 0.7913978494623656 0.7870967741935484 0.9945652173913043 0.3156225218080888 1261 +exclude_all_multicomponent_biopsies UQ_B25 UQ_B25 C1 VLP121_A UQ_P25 2.0 334 0.5658682634730539 0.5 0.8835978835978836 0.4771689497716895 876 +exclude_all_multicomponent_biopsies UQ_B30 UQ_B30 C2 VLP121_D UQ_P30 0.0 405 0.6370370370370371 0.24444444444444444 0.38372093023255816 0.4234647112740605 1091 +exclude_all_multicomponent_biopsies UQ_B29 UQ_B29 C1 VLP121_D UQ_P29 4.0 361 0.7091412742382271 0.7091412742382271 1.0 0.4224049331963001 973 +exclude_all_multicomponent_biopsies UQ_B33 UQ_B33 C5 VLP121_D UQ_P33 3.0 444 0.7477477477477478 0.7364864864864865 0.9849397590361446 0.35175879396984927 1194 +exclude_all_multicomponent_biopsies UQ_B32 UQ_B32 C4 VLP121_D UQ_P32 3.0 284 0.7464788732394366 0.7288732394366197 0.9764150943396226 0.3724966622162884 749 +exclude_all_multicomponent_biopsies UQ_B31 UQ_B31 C3 VLP121_D UQ_P31 0.0 189 0.6084656084656085 0.4708994708994709 0.7739130434782608 0.502127659574468 470 diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/UQ_spot_geometry_registration_audit.parquet b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_spot_geometry_registration_audit.parquet new file mode 100644 index 0000000..e2e1533 Binary files /dev/null and b/results/S15_UQ_biopsy_mapping_sensitivity/UQ_spot_geometry_registration_audit.parquet differ diff --git a/results/S15_UQ_biopsy_mapping_sensitivity/geometry/UQ_Visium_component_geometry.png b/results/S15_UQ_biopsy_mapping_sensitivity/geometry/UQ_Visium_component_geometry.png new file mode 100644 index 0000000..fa1593b Binary files /dev/null and b/results/S15_UQ_biopsy_mapping_sensitivity/geometry/UQ_Visium_component_geometry.png differ diff --git a/scripts/finalize_release.py b/scripts/finalize_release.py new file mode 100644 index 0000000..bf4f775 --- /dev/null +++ b/scripts/finalize_release.py @@ -0,0 +1,46 @@ +#!/usr/bin/env python3 +"""Write deterministic file and SHA-256 manifests for the release.""" + +from __future__ import annotations + +import hashlib +from pathlib import Path + + +ROOT = Path(__file__).resolve().parents[1] +FILE_MANIFEST = ROOT / "FILE_MANIFEST.txt" +SHA256SUMS = ROOT / "SHA256SUMS.txt" +EXCLUDED = { + FILE_MANIFEST.name, + SHA256SUMS.name, + "release_validation_report.json", +} + + +def included_files() -> list[Path]: + return sorted( + path + for path in ROOT.rglob("*") + if path.is_file() + and path.name not in EXCLUDED + and ".git" not in path.parts + and "__pycache__" not in path.parts + and path.name != ".DS_Store" + ) + + +def main() -> None: + files = included_files() + manifest_lines = ["bytes\tpath"] + checksum_lines = [] + for path in files: + relative = path.relative_to(ROOT).as_posix() + manifest_lines.append(f"{path.stat().st_size}\t{relative}") + checksum_lines.append(f"{hashlib.sha256(path.read_bytes()).hexdigest()} {relative}") + FILE_MANIFEST.write_text("\n".join(manifest_lines) + "\n", encoding="utf-8") + SHA256SUMS.write_text("\n".join(checksum_lines) + "\n", encoding="utf-8") + print(f"finalized {len(files)} files") + + +if __name__ == "__main__": + main() diff --git a/scripts/validate_release.py b/scripts/validate_release.py new file mode 100644 index 0000000..bf4390a --- /dev/null +++ b/scripts/validate_release.py @@ -0,0 +1,465 @@ +#!/usr/bin/env python3 +"""Adversarially validate release structure, provenance, privacy, and results.""" + +from __future__ import annotations + +import argparse +import csv +import gzip +import hashlib +import json +import os +from pathlib import Path +import re +import shutil +import subprocess +import sys +import tempfile + +import numpy as np +import pandas as pd + + +ROOT = Path(__file__).resolve().parents[1] +REPORT = ROOT / "release_validation_report.json" +MANIFEST_EXCLUDED = {"FILE_MANIFEST.txt", "SHA256SUMS.txt", REPORT.name} +TEXT_SUFFIXES = {".md", ".txt", ".py", ".r", ".sh", ".json", ".tsv", ".csv", ".cff", ".yaml", ".yml", ".toml"} +FORBIDDEN_NAMES = ( + "author_information", + "ethics_approval", + "clinical_hash_salt", + "flow_liver_stiffness_90d_linkage", + "matched_90d", + "private_submission", +) +SECRET_PATTERNS = { + "ssh_host": re.compile(r"connect[.]singapore|gpuhub[.]com", re.I), + "ssh_command": re.compile(r"ssh\s+root@", re.I), + "proxy_subscription": re.compile(r"ta30[.]vip|clash subscription", re.I), + "email_address": re.compile(r"\b[A-Z0-9._%+-]+@[A-Z0-9.-]+[.][A-Z]{2,}\b", re.I), + "private_key": re.compile(r"BEGIN (?:RSA |OPENSSH |EC )?PRIVATE KEY"), + "machine_absolute_path": re.compile(r"(?:^|[\s\"'(])/(?:Volumes|Users|root|autodl(?:-fs|-tmp)?)/", re.M), +} +PROHIBITED_CLINICAL_COLUMNS = { + "name", "patient_name", "medical_record_number", "mrn", "identity_card", "id_card", + "birth_date", "date_of_birth", "dob", "phone", "address", "email", "patient_hash", + "subject_hash", "event_hash", "encounter_date", +} +REQUIRED_ANALYSIS_SCRIPTS = [ + "code/clinical/rebuild_final_clinical_visuals.py", + "code/mouse/GSE295293_prepare_pseudobulk.py", + "code/mouse/GSE295293_dynamic_pseudobulk.R", + "code/mouse/GSE305331_stream_state_trajectories.py", + "code/mouse/mouse_resolver_lock_trajectory.py", + "code/human_hsc/GSE244832_prepare_hsc_map.py", + "code/human_hsc/GSE244832_stream_hsc_pseudobulk.cpp", + "code/human_hsc/GSE244832_hsc_donor_edger.R", + "code/human_hsc/GSE244832_integrate_retention_candidates.py", + "code/macrophage/GSE261829_macrophage_resolution.R", + "code/atlas/m2_gse136103_build_h5ad.py", + "code/atlas/m2_gse136103_scanpy_cluster_signature.py", + "code/atlas/m2_gse136103_cell_state_label_v1.py", + "code/atlas/m2_gse136103_cell_state_pseudobulk_de.py", + "code/spatial/UQ_Visium_component_audit.py", + "code/spatial/UQ_Visium_resolver_window_analysis.py", + "code/spatial/uq_spatial_proteolytic_lock.py", + "code/spatial/uq_phase_basin_control.py", + "code/spatial/spatial_domain_wall_resolver_window.py", + "code/spatial/UQ_biopsy_mapping_sensitivity.py", + "code/codex/UQ_CODEX_spatial_protein_validation.py", + "code/perturbation/prepare_v16_hsc_control_perturbation.py", + "code/perturbation/scgpt_v16_hsc_control_perturbation.py", + "code/perturbation/v15_celloracle_native_cpu.py", + "code/perturbation/celloracle_v16_ap1_runx2_test.py", + "code/perturbation/LINCS_AP1_genetic_perturbation.py", + "code/perturbation/stage4_regulatory_drug_control.py", + "code/perturbation/stage4_drug_hard_gate.py", + "code/perturbation/sequential_basin_switch_drugs.py", + "code/figures/build_mechanism_circuit.py", + "code/figures/rebuild_main_figure_plates.py", +] + + +class Audit: + def __init__(self) -> None: + self.checks: list[dict[str, str]] = [] + self.diagnostics: list[str] = [] + + def check(self, condition: bool, label: str, evidence: str = "") -> None: + self.checks.append({"status": "PASS" if condition else "FAIL", "label": label, "evidence": evidence}) + + @property + def failures(self) -> list[dict[str, str]]: + return [row for row in self.checks if row["status"] == "FAIL"] + + +def parse_args() -> argparse.Namespace: + parser = argparse.ArgumentParser(description=__doc__) + parser.add_argument("--rebuild", action="store_true", help="Rebuild four high-risk panels and compare PNG hashes") + parser.add_argument("--skip-manifest", action="store_true", help="Skip FILE_MANIFEST and SHA256SUMS verification during development") + return parser.parse_args() + + +def sha256(path: Path) -> str: + return hashlib.sha256(path.read_bytes()).hexdigest() + + +def release_files() -> list[Path]: + return sorted( + path for path in ROOT.rglob("*") + if path.is_file() + and path.name not in MANIFEST_EXCLUDED + and ".git" not in path.parts + and "__pycache__" not in path.parts + and path.name != ".DS_Store" + ) + + +def table_rows(path: Path) -> tuple[list[str], list[list[str]]]: + delimiter = "\t" if path.suffix.lower() == ".tsv" else "," + opener = gzip.open if path.suffix.lower() == ".gz" else open + with opener(path, "rt", encoding="utf-8-sig", newline="") as handle: + rows = list(csv.reader(handle, delimiter=delimiter)) + return (rows[0] if rows else []), rows[1:] + + +def check_structure(audit: Audit, files: list[Path]) -> None: + audit.check(len(files) > 150, "repository contains the expected release assets", f"n={len(files)}") + missing = [path for path in REQUIRED_ANALYSIS_SCRIPTS if not (ROOT / path).is_file()] + audit.check(not missing, "all main-analysis scripts are present", "; ".join(missing)) + + bad_names = [str(path.relative_to(ROOT)) for path in files if any(token in path.name.lower() for token in FORBIDDEN_NAMES)] + audit.check(not bad_names, "no forbidden private or linkage filenames", "; ".join(bad_names)) + + residue = [str(path.relative_to(ROOT)) for path in ROOT.rglob("*") if "__pycache__" in path.parts or path.name == ".DS_Store"] + audit.check(not residue, "no cache or Finder residue", "; ".join(residue[:20])) + + required_audit = [ + "docs/PANEL_PROVENANCE.tsv", + "docs/METHODS_AUDIT_SUMMARY.md", + "docs/methods_audit/Dataset_Master_Table.xlsx", + "docs/methods_audit/GSE306327_Methods_Notes.docx", + "docs/methods_audit/UQ_Reconstruction_Audit.xlsx", + "docs/methods_audit/UQ_BIOPSY_RECONSTRUCTION_PROVENANCE.md", + "docs/methods_audit/Drug_Order_Scoring_Specification.docx", + "docs/methods_audit/Prespecification_and_Analysis_Timeline.docx", + "docs/methods_audit/Figure_Panel_Statistics.xlsx", + "docs/methods_audit/Reviewer_Response_and_Repair_Matrix.xlsx", + "docs/methods_audit/machine_readable/Analysis_Timeline.tsv", + "docs/methods_audit/machine_readable/Drug_Order_Complete_Results.tsv", + "docs/methods_audit/machine_readable/UQ_Biopsy_Reconstruction_Map.tsv", + "data/mechanism_summary/mechanism_edge_evidence.tsv", + ] + missing_audit = [path for path in required_audit if not (ROOT / path).is_file()] + audit.check(not missing_audit, "methods-audit assets are complete", "; ".join(missing_audit)) + + main = ROOT / "figures/main" + revised = ROOT / "figures/reviewer_revision" + supplementary = ROOT / "figures/supplementary" + for suffix in ("png", "pdf"): + count = len(list(main.glob(f"Figure_*.{suffix}"))) + audit.check(count == 7, f"seven main figures in {suffix.upper()} format", f"n={count}") + count = len(list(main.glob("Figure_*.svg"))) + audit.check(count == 4, "four editable main figures in SVG format", f"n={count}") + count = len(list((ROOT / "figures/source_panels").glob("Fig7*.svg"))) + audit.check(count == 4, "four editable Figure 7 source panels", f"n={count}") + for suffix in ("png", "pdf", "svg"): + count = len(list(revised.glob(f"Fig[3467]*.{suffix}"))) + audit.check(count == 4, f"four replacement panels in {suffix.upper()} format", f"n={count}") + count = len(list(supplementary.glob("Supplementary_Figure_S*.png"))) + audit.check(count == 30, "thirty supplementary figures", f"n={count}") + + +def check_text_and_privacy(audit: Audit, files: list[Path]) -> None: + hits: list[str] = [] + for path in files: + if path.resolve() == Path(__file__).resolve() or path.suffix.lower() not in TEXT_SUFFIXES: + continue + try: + text = path.read_text(encoding="utf-8") + except UnicodeDecodeError: + continue + for label, pattern in SECRET_PATTERNS.items(): + if pattern.search(text): + hits.append(f"{path.relative_to(ROOT)}:{label}") + audit.check(not hits, "no credentials, endpoints, email addresses, keys, or machine paths", "; ".join(hits[:30])) + + disclosure: list[str] = [] + for folder in (ROOT / "data/clinical_aggregate", ROOT / "data/flow_aggregate"): + for path in sorted(folder.glob("*.tsv")): + headers, _ = table_rows(path) + overlap = sorted({header.strip().lower() for header in headers} & PROHIBITED_CLINICAL_COLUMNS) + if overlap: + disclosure.append(f"{path.relative_to(ROOT)}:{','.join(overlap)}") + audit.check(not disclosure, "aggregate clinical tables contain no direct or linkable identifiers", "; ".join(disclosure)) + + +def check_machine_readability(audit: Audit, files: list[Path]) -> None: + errors: list[str] = [] + inconsistent: list[str] = [] + for path in files: + relative = path.relative_to(ROOT) + if path.suffix.lower() == ".json": + try: + json.loads(path.read_text(encoding="utf-8")) + except Exception as exc: + errors.append(f"{relative}:{exc}") + elif path.suffix.lower() in {".tsv", ".csv"}: + try: + header, rows = table_rows(path) + bad = [index + 2 for index, row in enumerate(rows) if len(row) != len(header)] + if bad: + inconsistent.append(f"{relative}:header={len(header)},bad_lines={bad[:8]}") + except Exception as exc: + errors.append(f"{relative}:{exc}") + audit.check(not errors, "all JSON and delimited text files are readable", "; ".join(errors[:20])) + audit.check(not inconsistent, "all TSV and CSV rows match their header width", "; ".join(inconsistent[:20])) + + syntax_errors: list[str] = [] + for path in sorted((ROOT / "code").rglob("*.py")) + sorted((ROOT / "scripts").rglob("*.py")): + try: + compile(path.read_text(encoding="utf-8"), str(path), "exec") + except SyntaxError as exc: + syntax_errors.append(f"{path.relative_to(ROOT)}:{exc}") + audit.check(not syntax_errors, "all Python scripts compile", "; ".join(syntax_errors)) + + rscript = shutil.which("Rscript") or "/opt/homebrew/bin/Rscript" + r_errors: list[str] = [] + if Path(rscript).exists(): + for path in sorted((ROOT / "code").rglob("*.R")): + result = subprocess.run([rscript, "-e", "parse(file=commandArgs(TRUE)[1])", str(path)], capture_output=True, text=True) + if result.returncode: + r_errors.append(f"{path.relative_to(ROOT)}:{result.stderr.strip()[-300:]}") + audit.check(not r_errors, "all R scripts parse", "; ".join(r_errors)) + + +def check_environments(audit: Audit) -> None: + requirements = (ROOT / "environment/requirements.txt").read_text().splitlines() + bad_python = [line for line in requirements if line.strip().lower().startswith("python")] + audit.check(not bad_python, "requirements.txt contains only pip-valid requirements", "; ".join(bad_python)) + lock = (ROOT / "environment/requirements-lock.txt").read_text().lower() + required = ["numpy==", "pandas==", "scanpy==", "diptest==", "scikit-image==", "statsmodels=="] + missing = [name for name in required if name not in lock] + audit.check(not missing, "core Python transitive lock is complete", "; ".join(missing)) + pyproject = (ROOT / "pyproject.toml").read_text() + audit.check('requires-python = ">=3.11,<3.12"' in pyproject, "Python runtime is constrained in pyproject.toml") + rlock = pd.read_csv(ROOT / "environment/R-packages.lock.tsv", sep="\t") + audit.check({"R", "edgeR", "limma", "data.table"}.issubset(set(rlock.package)), "R runtime and edgeR stack are version-recorded") + + +def check_numeric_anchors(audit: Audit) -> None: + mechanism = pd.read_csv(ROOT / "data/mechanism_summary/mechanism_edge_evidence.tsv", sep="\t") + expected_classes = { + "literature-established", + "project-supported association", + "testable candidate edge", + } + audit.check(len(mechanism) == 24, "mechanism circuit contains 24 traceable edges", f"n={len(mechanism)}") + audit.check( + set(mechanism["evidence_class"]) == expected_classes, + "mechanism circuit preserves all three evidence classes", + "; ".join(sorted(set(mechanism["evidence_class"]))), + ) + + clinical = json.loads((ROOT / "data/clinical_aggregate/clinical_analysis_summary.json").read_text()) + outcomes = pd.read_csv(ROOT / "data/clinical_aggregate/longitudinal_outcomes.tsv", sep="\t") + audit.check(clinical["cohort"]["adult_index_patients"] == 8142, "clinical patient anchor recomputes", "n=8142") + audit.check(int(outcomes["n"].sum()) == 772, "longitudinal patient anchor recomputes", f"n={int(outcomes['n'].sum())}") + + phase = ROOT / "data/UQ_spatial_derived/S11_UQ_phase_basin_control" + blocks = pd.read_parquet(phase / "phase_spatial_blocks.parquet") + bic = pd.read_csv(phase / "phase_gmm_model_selection.tsv", sep="\t").set_index("n_components") + gain = float(bic.loc[1, "bic"] - bic.loc[2, "bic"]) + audit.check(len(blocks) == 589, "spatial block anchor recomputes", f"n={len(blocks)}") + audit.check(abs(gain - 141.01218590066708) < 1e-9, "one-versus-two-component BIC gain recomputes", f"gain={gain:.12f}") + + wall = pd.read_csv(ROOT / "data/UQ_spatial_derived/S14_spatial_domain_wall/spatial_domain_stage_trends.tsv", sep="\t").set_index("metric") + largest = float(wall.loc["largest_locked_domain_fraction", "stage_beta_array_adjusted"]) + interface = float(wall.loc["interface_edge_fraction", "stage_beta_array_adjusted"]) + audit.check(abs(largest - 0.09603914800529065) < 1e-12, "largest retention-domain slope recomputes", f"beta={largest:.12f}") + audit.check(abs(interface + 0.028733200324141162) < 1e-12, "cross-state interface slope recomputes", f"beta={interface:.12f}") + + mapping_dir = ROOT / "results/S15_UQ_biopsy_mapping_sensitivity" + mapping_summary = json.loads((mapping_dir / "UQ_biopsy_mapping_sensitivity_summary.json").read_text()) + audit.check( + mapping_summary["direct_geometry_spots"] == 13539 + and mapping_summary["nearest_component_rescue_spots"] == 46 + and mapping_summary["direct_geometry_match_rate"] == 1.0, + "score-independent UQ geometry reconstruction recomputes", + "direct=13539; rescue=46; agreement=100%", + ) + audit.check( + mapping_summary["scenario_key_direction_pass"] == 12 + and mapping_summary["scenario_key_direction_total"] == 12 + and mapping_summary["leave_one_array_out_key_direction_pass"] == 16 + and mapping_summary["leave_one_array_out_key_direction_total"] == 16, + "UQ mapping stress tests preserve both key effect directions", + "scenarios=12/12; leave-one-array-out=16/16", + ) + + mouse = pd.read_csv(ROOT / "data/UQ_spatial_derived/S13_mouse_resolver_lock_trajectory/GSE295293_mouse_phase_scores.tsv", sep="\t") + centroids = mouse.groupby("condition")[["resolver_axis", "lock_axis"]].mean() + control = centroids.loc["control"].to_numpy() + fibrosis = centroids.loc["fibrosis"].to_numpy() + regression = centroids.loc["regression"].to_numpy() + ratio = float(np.linalg.norm(regression - control) / np.linalg.norm(fibrosis - control)) + audit.check(abs(ratio - 0.6983693102084559) < 1e-12, "mouse residual-distance ratio recomputes", f"ratio={ratio:.12f}") + + compounds = pd.read_csv(ROOT / "data/LINCS_derived/LINCS_name_collapsed_hard_gated.tsv", sep="\t").set_index("pert_iname_norm") + early = compounds.loc["ezetimibe"] + late = compounds.loc["verteporfin"] + + def score(first: pd.Series, second: pd.Series) -> float: + endo = first.median_endo_support + 0.5 * second.median_endo_support + macro = first.median_macro_support + 0.5 * second.median_macro_support + retention = second.median_retention_suppression + 0.5 * first.median_retention_suppression + return float(retention + 0.5 * endo + 0.5 * macro - 1.5 * max(0.0, -min(endo, macro))) + + forward, reverse = score(early, late), score(late, early) + eligibility = ( + bool(early.identity_resolved) and early.n_signatures >= 3 and early.n_cell_lines >= 2 + and early.median_resolver_floor >= 0.10 + and 0.5 * (early.median_endo_support + early.median_macro_support) >= 0.20 + and early.median_retention_suppression >= -0.10 + and bool(late.identity_resolved) and late.n_signatures >= 3 and late.n_cell_lines >= 2 + and late.median_retention_suppression >= 0.20 + and late.q25_retention_suppression >= 0.10 + and late.median_resolver_floor >= -0.15 + ) + audit.check(eligibility, "lead compounds satisfy archived role thresholds") + audit.check(abs(forward - 0.8923123237262998) < 1e-12, "forward order-aware score recomputes", f"score={forward:.12f}") + audit.check(abs(reverse - 0.5041988742064742) < 1e-12, "reverse order-aware score recomputes", f"score={reverse:.12f}") + + +def check_rebuild(audit: Audit) -> None: + script = ROOT / "code/reviewer_revision/rebuild_high_risk_panels.py" + expected = ROOT / "figures/reviewer_revision" + stems = [ + "Fig3D_Categorical_Evidence", + "Fig4F_CODEX_SectionConcordance", + "Fig6_Static_TwoComponent_Revision", + "Fig7D_OrderAwareScore_Audit", + ] + with tempfile.TemporaryDirectory(prefix="pathoniche-rebuild-") as temp: + temp_root = Path(temp) + output = temp_root / "figures" + env = dict(os.environ) + env["MPLCONFIGDIR"] = str(temp_root / "mplconfig") + result = subprocess.run([sys.executable, str(script), "--output-dir", str(output)], cwd=ROOT, env=env, capture_output=True, text=True) + audit.check(result.returncode == 0, "high-risk panel rebuild completes", result.stderr.strip()[-500:]) + if result.returncode == 0: + mismatches = [stem for stem in stems if sha256(output / f"{stem}.png") != sha256(expected / f"{stem}.png")] + audit.check(not mismatches, "rebuilt high-risk PNGs match frozen SHA-256", "; ".join(mismatches)) + + mechanism_output = temp_root / "source_panels/Fig7A_Evidence_Coded_Mechanism" + mechanism_result = subprocess.run( + [ + sys.executable, + str(ROOT / "code/figures/build_mechanism_circuit.py"), + "--output", + str(mechanism_output), + ], + cwd=ROOT, + env=env, + capture_output=True, + text=True, + ) + audit.check(mechanism_result.returncode == 0, "mechanism circuit rebuild completes", mechanism_result.stderr.strip()[-500:]) + if mechanism_result.returncode == 0: + same = sha256(mechanism_output.with_suffix(".png")) == sha256( + ROOT / "figures/source_panels/Fig7A_Evidence_Coded_Mechanism.png" + ) + audit.check(same, "rebuilt mechanism PNG matches frozen SHA-256") + + plate_input = temp_root / "main" + plate_input.mkdir(parents=True, exist_ok=True) + editable_stems = [ + "Figure_1_Clinical_Cohort_and_Persistence", + "Figure_2_Withdrawal_and_Resolver_Timing", + "Figure_5_Progressive_Retention_Domain_Occupation", + ] + for stem in editable_stems: + shutil.copy2(ROOT / f"figures/main/{stem}.svg", plate_input / f"{stem}.svg") + plate_result = subprocess.run( + [ + sys.executable, + str(ROOT / "code/figures/rebuild_main_figure_plates.py"), + "--figures-dir", + str(plate_input), + "--source-panels", + str(ROOT / "figures/source_panels"), + ], + cwd=ROOT, + env=env, + capture_output=True, + text=True, + ) + audit.check(plate_result.returncode == 0, "editable main-plate rebuild completes", plate_result.stderr.strip()[-500:]) + if plate_result.returncode == 0: + plate_stems = editable_stems + ["Figure_7_Mechanism_and_OrderAware_Nomination"] + mismatches = [ + stem + for stem in plate_stems + if sha256(plate_input / f"{stem}.png") != sha256(ROOT / f"figures/main/{stem}.png") + ] + audit.check(not mismatches, "rebuilt editable main PNGs match frozen SHA-256", "; ".join(mismatches)) + + +def check_manifests(audit: Audit, files: list[Path]) -> None: + checksum_path = ROOT / "SHA256SUMS.txt" + manifest_path = ROOT / "FILE_MANIFEST.txt" + expected_paths = {path.relative_to(ROOT).as_posix() for path in files} + recorded: dict[str, str] = {} + for line in checksum_path.read_text().splitlines(): + if not line.strip(): + continue + digest, relative = line.split(" ", 1) + recorded[relative] = digest + missing = sorted(expected_paths - set(recorded)) + extra = sorted(set(recorded) - expected_paths) + mismatched = sorted(relative for relative in expected_paths & set(recorded) if sha256(ROOT / relative) != recorded[relative]) + audit.check(not missing and not extra, "SHA256SUMS covers the exact release file set", f"missing={missing[:8]}; extra={extra[:8]}") + audit.check(not mismatched, "all recorded SHA-256 checksums verify", "; ".join(mismatched[:20])) + + lines = manifest_path.read_text().splitlines() + entries = {} + for line in lines[1:]: + size, relative = line.split("\t", 1) + entries[relative] = int(size) + size_mismatch = sorted(relative for relative in expected_paths & set(entries) if entries[relative] != (ROOT / relative).stat().st_size) + audit.check(set(entries) == expected_paths and not size_mismatch, "FILE_MANIFEST records exact paths and byte sizes", f"size_mismatch={size_mismatch[:8]}") + + +def main() -> int: + args = parse_args() + audit = Audit() + files = release_files() + check_structure(audit, files) + check_text_and_privacy(audit, files) + check_machine_readability(audit, files) + check_environments(audit) + check_numeric_anchors(audit) + if args.rebuild: + check_rebuild(audit) + if not args.skip_manifest: + check_manifests(audit, files) + + checksums = {str(path.relative_to(ROOT)): sha256(path) for path in files} + report = { + "release": (ROOT / "VERSION").read_text().strip(), + "status": "PASS" if not audit.failures else "FAIL", + "file_count": len(files), + "checks": audit.checks, + "pass_count": len(audit.checks) - len(audit.failures), + "failure_count": len(audit.failures), + "sha256": checksums, + } + REPORT.write_text(json.dumps(report, indent=2, ensure_ascii=True) + "\n", encoding="utf-8") + print(f"{report['status']}: {report['pass_count']} checks passed; {report['failure_count']} failed") + for failure in audit.failures: + print(f"FAIL: {failure['label']} :: {failure['evidence']}") + return 0 if not audit.failures else 1 + + +if __name__ == "__main__": + sys.exit(main()) diff --git a/uv.lock b/uv.lock new file mode 100644 index 0000000..3e6b202 --- /dev/null +++ b/uv.lock @@ -0,0 +1,841 @@ +version = 1 +revision = 3 +requires-python = "==3.11.*" + +[[package]] +name = "anndata" +version = "0.12.19" +source = { registry = "https://pypi.org/simple" } +dependencies = [ + { name = "array-api-compat" }, + { name = "h5py" }, + { name = "legacy-api-wrap" }, + { name = "natsort" }, + { name = "numpy" 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