From eb9e7579d0dbb264dbe1cbb15af6a2466db19213 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sun, 9 Jun 2024 15:50:27 +0100 Subject: [PATCH 01/24] [delete] duplicate --- src/mewpy/cobra/regcomfba.py | 53 ------------------------------------ 1 file changed, 53 deletions(-) delete mode 100644 src/mewpy/cobra/regcomfba.py diff --git a/src/mewpy/cobra/regcomfba.py b/src/mewpy/cobra/regcomfba.py deleted file mode 100644 index 776fcab0..00000000 --- a/src/mewpy/cobra/regcomfba.py +++ /dev/null @@ -1,53 +0,0 @@ -# Regularized Flux Balance Analysis for communities -from mewpy.solvers import solver_instance -from mewpy.simulation import get_simulator, SStatus, SimulationResult -from mewpy.com.com import CommunityModel -from mewpy.solvers.solution import to_simulation_result -from warnings import warn - -def regComFBA(model:CommunityModel, objective=None, minimize=False, constraints=None, alpha=0.9): - """ Run a Regularized Flux Balance Analysis simulation: - - Arguments: - model (CommunityModel): a constraint-based model - objective (dict: objective coefficients (optional) - minimize (bool): minimize objective function (False by default) - constraints (dict): environmental or additional constraints (optional) - - Returns: - Solution: solution - """ - sim = get_simulator(model) - - if not objective: - objective = sim.objective - if len(objective) == 0: - warn('Model objective undefined.') - - solver = solver_instance(sim) - - if not constraints: - constraints = {} - - if not objective: - objective = model.get_objective() - - pre_solution = sim.simulate(objective,minimize=minimize,constraints=constraints) - if pre_solution.status != SStatus.OPTIMAL: - return pre_solution - - solver.add_constraint('obj', objective, '>', - alpha * pre_solution.objective_value) - - solver.update() - - org_bio=list(model.get_organisms_biomass().values()) - qobjective = {(rid,rid):1 for rid in org_bio} - - solution = solver.solve(quadratic=qobjective, minimize=True, constraints=constraints) - - - - result = to_simulation_result(model, solution.fobj, constraints, sim, solution) - - return result From aedf2041e78f161fee4b6b919edcb1557b6d405d Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Wed, 19 Jun 2024 21:08:46 +0100 Subject: [PATCH 02/24] [UPDATE] Normalize comunity flux option --- examples/08-community.ipynb | 795 ++++++++++++++++++----------- src/mewpy/com/com.py | 367 +++++++------ src/mewpy/com/regfba.py | 8 +- src/mewpy/simulation/simulation.py | 3 + src/mewpy/simulation/simulator.py | 2 +- 5 files changed, 725 insertions(+), 450 deletions(-) diff --git a/examples/08-community.ipynb b/examples/08-community.ipynb index 3d496a86..fa2c1cc2 100644 --- a/examples/08-community.ipynb +++ b/examples/08-community.ipynb @@ -67,7 +67,7 @@ "output_type": "stream", "text": [ "MEWpy version: 0.1.34\n", - "Author: CEB University of Minho (2019-2023)/ Vitor Pereira (2019-)\n", + "Author: Vitor Pereira (2019-) | CEB University of Minho (2019-2023)\n", "Contact: vmsapereira@gmail.com \n", "\n", "Available LP solvers: gurobi glpk\n", @@ -95,7 +95,7 @@ "id": "6f2de219", "metadata": {}, "source": [ - "IMPORTANT: The notebooks require a MEWpy version >= 0.1.26" + "**IMPORTANT**: The notebook requires a MEWpy version >= 0.1.35" ] }, { @@ -166,7 +166,7 @@ "Academic license - for non-commercial use only - expires 2024-12-11\n", "objective: 0.8739215069684301\n", "Status: OPTIMAL\n", - "Method:SimulationMethod.FBA\n" + "Method:FBA\n" ] }, { @@ -276,7 +276,7 @@ "name": "stdout", "output_type": "stream", "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnc7t_1mi.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcimgyt8p.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n" ] @@ -298,7 +298,7 @@ "name": "stdout", "output_type": "stream", "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpemyidphq.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxd905hg4.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n" ] @@ -526,21 +526,29 @@ }, { "cell_type": "code", - "execution_count": 12, + "execution_count": 44, "id": "91e413e9", "metadata": {}, "outputs": [], "source": [ "from mewpy.model import CommunityModel\n", - "community = CommunityModel([glc_ko, nh4_ko],flavor='cobra')" + "community = CommunityModel([glc_ko, nh4_ko], flavor='cobra')" ] }, { "cell_type": "code", - "execution_count": 13, + "execution_count": 45, "id": "46ed57b9", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 4.59it/s]\n" + ] + } + ], "source": [ "sim = community.get_community_model()" ] @@ -557,7 +565,7 @@ }, { "cell_type": "code", - "execution_count": 14, + "execution_count": 46, "id": "6644486c", "metadata": {}, "outputs": [ @@ -699,7 +707,7 @@ "EX_succ_e\t0.0\t1000.0" ] }, - "execution_count": 14, + "execution_count": 46, "metadata": {}, "output_type": "execute_result" } @@ -722,7 +730,7 @@ }, { "cell_type": "code", - "execution_count": 15, + "execution_count": 47, "id": "47cb7a4b", "metadata": {}, "outputs": [ @@ -730,9 +738,9 @@ "name": "stdout", "output_type": "stream", "text": [ - "objective: 0.8311955501858121\n", + "objective: 0.40757209363986224\n", "Status: OPTIMAL\n", - "Method:SimulationMethod.FBA\n" + "Method:FBA\n" ] }, { @@ -770,45 +778,155 @@ " \n", " \n", " EX_h2o_e\n", - " 30.682819\n", + " 31.248968\n", " \n", " \n", " EX_h_e\n", - " 16.673783\n", + " 16.351792\n", " \n", " \n", " EX_nh4_e\n", - " -4.532343\n", + " -4.444818\n", " \n", " \n", " EX_o2_e\n", - " -23.667113\n", + " -24.368743\n", " \n", " \n", " EX_pi_e\n", - " -3.057719\n", + " -2.998671\n", " \n", " \n", " EX_co2_e\n", - " 24.628058\n", + " 25.311132\n", + " \n", + " \n", + " EX_glc__D_e_nh4_ko\n", + " -10.000000\n", + " \n", + " \n", + " EX_glu__L_e_glc_ko\n", + " 2.222409\n", + " \n", + " \n", + " EX_glu__L_e_nh4_ko\n", + " -2.222409\n", + " \n", + " \n", + " EX_h2o_e_glc_ko\n", + " 30.945021\n", + " \n", + " \n", + " EX_h2o_e_nh4_ko\n", + " 0.303946\n", + " \n", + " \n", + " EX_h_e_glc_ko\n", + " -5.029965\n", + " \n", + " \n", + " EX_h_e_nh4_ko\n", + " 21.381758\n", + " \n", + " \n", + " EX_lac__D_e_glc_ko\n", + " -20.076753\n", + " \n", + " \n", + " EX_lac__D_e_nh4_ko\n", + " 20.076753\n", + " \n", + " \n", + " EX_nh4_e_glc_ko\n", + " -4.444818\n", + " \n", + " \n", + " EX_o2_e_glc_ko\n", + " -19.052926\n", + " \n", + " \n", + " EX_o2_e_nh4_ko\n", + " -5.315818\n", + " \n", + " \n", + " EX_pi_e_glc_ko\n", + " -1.499335\n", + " \n", + " \n", + " EX_pi_e_nh4_ko\n", + " -1.499335\n", + " \n", + " \n", + " EX_pyr_e_glc_ko\n", + " 17.017435\n", + " \n", + " \n", + " EX_pyr_e_nh4_ko\n", + " -17.017435\n", + " \n", + " \n", + " EX_ac_e_glc_ko\n", + " -7.810667\n", + " \n", + " \n", + " EX_ac_e_nh4_ko\n", + " 7.810667\n", + " \n", + " \n", + " EX_akg_e_glc_ko\n", + " -3.390348\n", + " \n", + " \n", + " EX_akg_e_nh4_ko\n", + " 3.390348\n", + " \n", + " \n", + " EX_co2_e_glc_ko\n", + " 13.294545\n", + " \n", + " \n", + " EX_co2_e_nh4_ko\n", + " 12.016587\n", " \n", " \n", "\n", "" ], "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "EX_glc__D_e -10.000000\n", - "EX_h2o_e 30.682819\n", - "EX_h_e 16.673783\n", - "EX_nh4_e -4.532343\n", - "EX_o2_e -23.667113\n", - "EX_pi_e -3.057719\n", - "EX_co2_e 24.628058" + " Flux rate\n", + "Reaction ID \n", + "EX_glc__D_e -10.000000\n", + "EX_h2o_e 31.248968\n", + "EX_h_e 16.351792\n", + "EX_nh4_e -4.444818\n", + "EX_o2_e -24.368743\n", + "EX_pi_e -2.998671\n", + "EX_co2_e 25.311132\n", + "EX_glc__D_e_nh4_ko -10.000000\n", + "EX_glu__L_e_glc_ko 2.222409\n", + "EX_glu__L_e_nh4_ko -2.222409\n", + "EX_h2o_e_glc_ko 30.945021\n", + "EX_h2o_e_nh4_ko 0.303946\n", + "EX_h_e_glc_ko -5.029965\n", + "EX_h_e_nh4_ko 21.381758\n", + "EX_lac__D_e_glc_ko -20.076753\n", + "EX_lac__D_e_nh4_ko 20.076753\n", + "EX_nh4_e_glc_ko -4.444818\n", + "EX_o2_e_glc_ko -19.052926\n", + "EX_o2_e_nh4_ko -5.315818\n", + "EX_pi_e_glc_ko -1.499335\n", + "EX_pi_e_nh4_ko -1.499335\n", + "EX_pyr_e_glc_ko 17.017435\n", + "EX_pyr_e_nh4_ko -17.017435\n", + "EX_ac_e_glc_ko -7.810667\n", + "EX_ac_e_nh4_ko 7.810667\n", + "EX_akg_e_glc_ko -3.390348\n", + "EX_akg_e_nh4_ko 3.390348\n", + "EX_co2_e_glc_ko 13.294545\n", + "EX_co2_e_nh4_ko 12.016587" ] }, - "execution_count": 15, + "execution_count": 47, "metadata": {}, "output_type": "execute_result" } @@ -834,7 +952,7 @@ }, { "cell_type": "code", - "execution_count": 16, + "execution_count": 48, "id": "0b5d171f", "metadata": {}, "outputs": [ @@ -869,11 +987,11 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 0.000000\n", + " 0.407572\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 0.831196\n", + " 0.407572\n", " \n", " \n", "\n", @@ -882,11 +1000,11 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.000000\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.831196" + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" ] }, - "execution_count": 16, + "execution_count": 48, "metadata": {}, "output_type": "execute_result" } @@ -905,7 +1023,7 @@ }, { "cell_type": "code", - "execution_count": 17, + "execution_count": 49, "id": "960e9b0b", "metadata": {}, "outputs": [ @@ -943,10 +1061,10 @@ " \n", " \n", " \n", - " community_biomass\n", - " Total community biomass\n", - " e\n", - " None\n", + " glc__D_e_glc_ko\n", + " D-Glucose\n", + " e_glc_ko\n", + " C6H12O6\n", " \n", " \n", " glc__D_e\n", @@ -961,16 +1079,16 @@ " C5H10N2O3\n", " \n", " \n", - " gln__L_e\n", + " gln__L_e_glc_ko\n", " L-Glutamine\n", - " e\n", + " e_glc_ko\n", " C5H10N2O3\n", " \n", " \n", - " glu__L_c_glc_ko\n", - " L-Glutamate\n", - " c_glc_ko\n", - " C5H8NO4\n", + " gln__L_e\n", + " L-Glutamine\n", + " e\n", + " C5H10N2O3\n", " \n", " \n", " ...\n", @@ -979,21 +1097,15 @@ " ...\n", " \n", " \n", - " fdp_c_nh4_ko\n", - " D-Fructose 1,6-bisphosphate\n", - " c_nh4_ko\n", - " C6H10O12P2\n", - " \n", - " \n", - " for_c_nh4_ko\n", - " Formate\n", + " fum_c_nh4_ko\n", + " Fumarate\n", " c_nh4_ko\n", - " CH1O2\n", + " C4H2O4\n", " \n", " \n", - " fum_c_nh4_ko\n", + " fum_e_nh4_ko\n", " Fumarate\n", - " c_nh4_ko\n", + " e_nh4_ko\n", " C4H2O4\n", " \n", " \n", @@ -1008,30 +1120,36 @@ " c_nh4_ko\n", " C6H11O9P\n", " \n", + " \n", + " Biomass_nh4_ko\n", + " Biomass nh4_ko\n", + " e\n", + " None\n", + " \n", " \n", "\n", - "

125 rows × 3 columns

\n", + "

166 rows × 3 columns

\n", "" ], "text/plain": [ - " name compartment formula\n", - "id \n", - "community_biomass Total community biomass e None\n", - "glc__D_e D-Glucose e C6H12O6\n", - "gln__L_c_glc_ko L-Glutamine c_glc_ko C5H10N2O3\n", - "gln__L_e L-Glutamine e C5H10N2O3\n", - "glu__L_c_glc_ko L-Glutamate c_glc_ko C5H8NO4\n", - "... ... ... ...\n", - "fdp_c_nh4_ko D-Fructose 1,6-bisphosphate c_nh4_ko C6H10O12P2\n", - "for_c_nh4_ko Formate c_nh4_ko CH1O2\n", - "fum_c_nh4_ko Fumarate c_nh4_ko C4H2O4\n", - "g3p_c_nh4_ko Glyceraldehyde 3-phosphate c_nh4_ko C3H5O6P\n", - "g6p_c_nh4_ko D-Glucose 6-phosphate c_nh4_ko C6H11O9P\n", + " name compartment formula\n", + "id \n", + "glc__D_e_glc_ko D-Glucose e_glc_ko C6H12O6\n", + "glc__D_e D-Glucose e C6H12O6\n", + "gln__L_c_glc_ko L-Glutamine c_glc_ko C5H10N2O3\n", + "gln__L_e_glc_ko L-Glutamine e_glc_ko C5H10N2O3\n", + "gln__L_e L-Glutamine e C5H10N2O3\n", + "... ... ... ...\n", + "fum_c_nh4_ko Fumarate c_nh4_ko C4H2O4\n", + "fum_e_nh4_ko Fumarate e_nh4_ko C4H2O4\n", + "g3p_c_nh4_ko Glyceraldehyde 3-phosphate c_nh4_ko C3H5O6P\n", + "g6p_c_nh4_ko D-Glucose 6-phosphate c_nh4_ko C6H11O9P\n", + "Biomass_nh4_ko Biomass nh4_ko e None\n", "\n", - "[125 rows x 3 columns]" + "[166 rows x 3 columns]" ] }, - "execution_count": 17, + "execution_count": 49, "metadata": {}, "output_type": "execute_result" } @@ -1042,7 +1160,7 @@ }, { "cell_type": "code", - "execution_count": 18, + "execution_count": 50, "id": "a69cf655", "metadata": {}, "outputs": [ @@ -1077,27 +1195,23 @@ " \n", " \n", " ACKr_nh4_ko\n", - " -1.810642\n", + " -7.810667\n", " \n", " \n", " ACONTa_nh4_ko\n", - " 2.354571\n", + " 1.607668\n", " \n", " \n", " ACONTb_nh4_ko\n", - " 2.354571\n", + " 1.607668\n", " \n", " \n", " ACt2r_nh4_ko\n", - " -1.810642\n", - " \n", - " \n", - " AKGDH_nh4_ko\n", - " 1.457794\n", + " -7.810667\n", " \n", " \n", " AKGt2r_nh4_ko\n", - " -4.532343\n", + " -3.390348\n", " \n", " \n", " ATPM_nh4_ko\n", @@ -1105,47 +1219,43 @@ " \n", " \n", " ATPS4r_nh4_ko\n", - " 44.074005\n", + " 10.578752\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 0.831196\n", + " 0.407572\n", " \n", " \n", " CO2t_nh4_ko\n", - " -12.841670\n", + " -12.016587\n", " \n", " \n", " CS_nh4_ko\n", - " 2.354571\n", + " 1.607668\n", " \n", " \n", " CYTBD_nh4_ko\n", - " 40.080181\n", + " 10.631636\n", " \n", " \n", " D_LACt2_nh4_ko\n", - " 9.064686\n", + " -20.076753\n", " \n", " \n", " ENO_nh4_ko\n", - " 15.170027\n", + " 17.707169\n", " \n", " \n", " FBA_nh4_ko\n", - " 7.796272\n", - " \n", - " \n", - " FUM_nh4_ko\n", - " 1.457794\n", + " 8.994934\n", " \n", " \n", " G6PDH2r_nh4_ko\n", - " 4.130813\n", + " 1.798962\n", " \n", " \n", " GAPD_nh4_ko\n", - " 16.413495\n", + " 18.316897\n", " \n", " \n", " GLCpts_nh4_ko\n", @@ -1153,119 +1263,151 @@ " \n", " \n", " GLNS_nh4_ko\n", - " 0.212537\n", + " 0.104216\n", " \n", " \n", " GLUDy_nh4_ko\n", - " 0.212537\n", + " 0.104216\n", " \n", " \n", " GLUt2r_nh4_ko\n", - " 4.532343\n", + " 2.222409\n", " \n", " \n", " GND_nh4_ko\n", - " 4.130813\n", + " 1.798962\n", " \n", " \n", " H2Ot_nh4_ko\n", - " -30.682819\n", + " -0.303946\n", " \n", " \n", " ICDHyr_nh4_ko\n", - " 2.354571\n", + " 1.607668\n", " \n", " \n", " LDH_D_nh4_ko\n", - " 9.064686\n", - " \n", - " \n", - " MDH_nh4_ko\n", - " 1.457794\n", + " -20.076753\n", " \n", " \n", " NADH16_nh4_ko\n", - " 38.622387\n", + " 10.631636\n", " \n", " \n", " O2t_nh4_ko\n", - " 20.040090\n", + " 5.315818\n", " \n", " \n", " PDH_nh4_ko\n", - " 7.280367\n", + " 10.945833\n", " \n", " \n", " PFK_nh4_ko\n", - " 7.796272\n", + " 8.994934\n", " \n", " \n", " PGI_nh4_ko\n", - " 5.698792\n", + " 8.117486\n", " \n", " \n", " PGK_nh4_ko\n", - " -16.413495\n", + " -18.316897\n", " \n", " \n", " PGL_nh4_ko\n", - " 4.130813\n", + " 1.798962\n", " \n", " \n", " PGM_nh4_ko\n", - " -15.170027\n", + " -17.707169\n", " \n", " \n", " PIt2r_nh4_ko\n", - " 3.057719\n", + " 1.499335\n", " \n", " \n", " PPC_nh4_ko\n", - " 2.381874\n", + " 2.335877\n", " \n", " \n", " PTAr_nh4_ko\n", - " 1.810642\n", + " 7.810667\n", " \n", " \n", " PYK_nh4_ko\n", - " 2.356679\n", + " 5.159721\n", " \n", " \n", " PYRt2_nh4_ko\n", - " -11.786388\n", + " 17.017435\n", " \n", " \n", " RPE_nh4_ko\n", - " 2.156412\n", + " 0.906345\n", " \n", " \n", " RPI_nh4_ko\n", - " -1.974401\n", - " \n", - " \n", - " SUCDi_nh4_ko\n", - " 1.457794\n", - " \n", - " \n", - " SUCOAS_nh4_ko\n", - " -1.457794\n", + " -0.892617\n", " \n", " \n", " TALA_nh4_ko\n", - " 1.228237\n", + " 0.526739\n", " \n", " \n", " TKT1_nh4_ko\n", - " 1.228237\n", + " 0.526739\n", " \n", " \n", " TKT2_nh4_ko\n", - " 0.928175\n", + " 0.379606\n", " \n", " \n", " TPI_nh4_ko\n", - " 7.796272\n", + " 8.994934\n", + " \n", + " \n", + " EX_glc__D_e_nh4_ko\n", + " -10.000000\n", + " \n", + " \n", + " EX_glu__L_e_nh4_ko\n", + " -2.222409\n", + " \n", + " \n", + " EX_h2o_e_nh4_ko\n", + " 0.303946\n", + " \n", + " \n", + " EX_h_e_nh4_ko\n", + " 21.381758\n", + " \n", + " \n", + " EX_lac__D_e_nh4_ko\n", + " 20.076753\n", + " \n", + " \n", + " EX_o2_e_nh4_ko\n", + " -5.315818\n", + " \n", + " \n", + " EX_pi_e_nh4_ko\n", + " -1.499335\n", + " \n", + " \n", + " EX_pyr_e_nh4_ko\n", + " -17.017435\n", + " \n", + " \n", + " EX_ac_e_nh4_ko\n", + " 7.810667\n", + " \n", + " \n", + " EX_akg_e_nh4_ko\n", + " 3.390348\n", + " \n", + " \n", + " EX_co2_e_nh4_ko\n", + " 12.016587\n", " \n", " \n", "\n", @@ -1274,57 +1416,63 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "ACKr_nh4_ko -1.810642\n", - "ACONTa_nh4_ko 2.354571\n", - "ACONTb_nh4_ko 2.354571\n", - "ACt2r_nh4_ko -1.810642\n", - "AKGDH_nh4_ko 1.457794\n", - "AKGt2r_nh4_ko -4.532343\n", + "ACKr_nh4_ko -7.810667\n", + "ACONTa_nh4_ko 1.607668\n", + "ACONTb_nh4_ko 1.607668\n", + "ACt2r_nh4_ko -7.810667\n", + "AKGt2r_nh4_ko -3.390348\n", "ATPM_nh4_ko 8.390000\n", - "ATPS4r_nh4_ko 44.074005\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.831196\n", - "CO2t_nh4_ko -12.841670\n", - "CS_nh4_ko 2.354571\n", - "CYTBD_nh4_ko 40.080181\n", - "D_LACt2_nh4_ko 9.064686\n", - "ENO_nh4_ko 15.170027\n", - "FBA_nh4_ko 7.796272\n", - "FUM_nh4_ko 1.457794\n", - "G6PDH2r_nh4_ko 4.130813\n", - "GAPD_nh4_ko 16.413495\n", + "ATPS4r_nh4_ko 10.578752\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", + "CO2t_nh4_ko -12.016587\n", + "CS_nh4_ko 1.607668\n", + "CYTBD_nh4_ko 10.631636\n", + "D_LACt2_nh4_ko -20.076753\n", + "ENO_nh4_ko 17.707169\n", + "FBA_nh4_ko 8.994934\n", + "G6PDH2r_nh4_ko 1.798962\n", + "GAPD_nh4_ko 18.316897\n", "GLCpts_nh4_ko 10.000000\n", - "GLNS_nh4_ko 0.212537\n", - "GLUDy_nh4_ko 0.212537\n", - "GLUt2r_nh4_ko 4.532343\n", - "GND_nh4_ko 4.130813\n", - "H2Ot_nh4_ko -30.682819\n", - "ICDHyr_nh4_ko 2.354571\n", - "LDH_D_nh4_ko 9.064686\n", - "MDH_nh4_ko 1.457794\n", - "NADH16_nh4_ko 38.622387\n", - "O2t_nh4_ko 20.040090\n", - "PDH_nh4_ko 7.280367\n", - "PFK_nh4_ko 7.796272\n", - "PGI_nh4_ko 5.698792\n", - "PGK_nh4_ko -16.413495\n", - "PGL_nh4_ko 4.130813\n", - "PGM_nh4_ko -15.170027\n", - "PIt2r_nh4_ko 3.057719\n", - "PPC_nh4_ko 2.381874\n", - "PTAr_nh4_ko 1.810642\n", - "PYK_nh4_ko 2.356679\n", - "PYRt2_nh4_ko -11.786388\n", - "RPE_nh4_ko 2.156412\n", - "RPI_nh4_ko -1.974401\n", - "SUCDi_nh4_ko 1.457794\n", - "SUCOAS_nh4_ko -1.457794\n", - "TALA_nh4_ko 1.228237\n", - "TKT1_nh4_ko 1.228237\n", - "TKT2_nh4_ko 0.928175\n", - "TPI_nh4_ko 7.796272" + "GLNS_nh4_ko 0.104216\n", + "GLUDy_nh4_ko 0.104216\n", + "GLUt2r_nh4_ko 2.222409\n", + "GND_nh4_ko 1.798962\n", + "H2Ot_nh4_ko -0.303946\n", + "ICDHyr_nh4_ko 1.607668\n", + "LDH_D_nh4_ko -20.076753\n", + "NADH16_nh4_ko 10.631636\n", + "O2t_nh4_ko 5.315818\n", + "PDH_nh4_ko 10.945833\n", + "PFK_nh4_ko 8.994934\n", + "PGI_nh4_ko 8.117486\n", + "PGK_nh4_ko -18.316897\n", + "PGL_nh4_ko 1.798962\n", + "PGM_nh4_ko -17.707169\n", + "PIt2r_nh4_ko 1.499335\n", + "PPC_nh4_ko 2.335877\n", + "PTAr_nh4_ko 7.810667\n", + "PYK_nh4_ko 5.159721\n", + "PYRt2_nh4_ko 17.017435\n", + "RPE_nh4_ko 0.906345\n", + "RPI_nh4_ko -0.892617\n", + "TALA_nh4_ko 0.526739\n", + "TKT1_nh4_ko 0.526739\n", + "TKT2_nh4_ko 0.379606\n", + "TPI_nh4_ko 8.994934\n", + "EX_glc__D_e_nh4_ko -10.000000\n", + "EX_glu__L_e_nh4_ko -2.222409\n", + "EX_h2o_e_nh4_ko 0.303946\n", + "EX_h_e_nh4_ko 21.381758\n", + "EX_lac__D_e_nh4_ko 20.076753\n", + "EX_o2_e_nh4_ko -5.315818\n", + "EX_pi_e_nh4_ko -1.499335\n", + "EX_pyr_e_nh4_ko -17.017435\n", + "EX_ac_e_nh4_ko 7.810667\n", + "EX_akg_e_nh4_ko 3.390348\n", + "EX_co2_e_nh4_ko 12.016587" ] }, - "execution_count": 18, + "execution_count": 50, "metadata": {}, "output_type": "execute_result" } @@ -1357,7 +1505,7 @@ }, { "cell_type": "code", - "execution_count": 19, + "execution_count": 51, "id": "c4727cf5", "metadata": {}, "outputs": [], @@ -1367,7 +1515,7 @@ }, { "cell_type": "code", - "execution_count": 20, + "execution_count": 52, "id": "c80e5339", "metadata": {}, "outputs": [ @@ -1410,29 +1558,29 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 2.225757e-16\n", + " 0.407572\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 8.311956e-01\n", + " 0.407572\n", " \n", " \n", " community_growth\n", - " 8.311956e-01\n", + " 0.407572\n", " \n", " \n", "\n", "" ], "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 2.225757e-16\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 8.311956e-01\n", - "community_growth 8.311956e-01" + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", + "community_growth 0.407572" ] }, - "execution_count": 20, + "execution_count": 52, "metadata": {}, "output_type": "execute_result" } @@ -1452,7 +1600,7 @@ }, { "cell_type": "code", - "execution_count": 21, + "execution_count": 53, "id": "e6698a36", "metadata": {}, "outputs": [ @@ -1495,29 +1643,29 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 2.225757e-16\n", + " 0.407572\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 8.311956e-01\n", + " 0.407572\n", " \n", " \n", " community_growth\n", - " 8.311956e-01\n", + " 0.407572\n", " \n", " \n", "\n", "" ], "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 2.225757e-16\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 8.311956e-01\n", - "community_growth 8.311956e-01" + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", + "community_growth 0.407572" ] }, - "execution_count": 21, + "execution_count": 53, "metadata": {}, "output_type": "execute_result" } @@ -1547,7 +1695,7 @@ }, { "cell_type": "code", - "execution_count": 22, + "execution_count": 54, "id": "2214667c", "metadata": {}, "outputs": [ @@ -1558,6 +1706,13 @@ "Set parameter FeasibilityTol to value 1e-09\n", "Set parameter OptimalityTol to value 1e-09\n" ] + }, + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.15it/s]\n" + ] } ], "source": [ @@ -1574,19 +1729,19 @@ }, { "cell_type": "code", - "execution_count": 23, + "execution_count": 55, "id": "50794ba1", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "Community growth: 0.873046875\n", - "glc_ko\t0.019267933674315795\n", - "nh4_ko\t0.9807320663256842" + "Community growth: 0.027466848121535575\n", + "glc_ko\t1.0\n", + "nh4_ko\t30.785477210087368" ] }, - "execution_count": 23, + "execution_count": 55, "metadata": {}, "output_type": "execute_result" } @@ -1605,7 +1760,7 @@ }, { "cell_type": "code", - "execution_count": 24, + "execution_count": 56, "id": "e5b8887e", "metadata": {}, "outputs": [ @@ -1638,53 +1793,67 @@ " \n", " \n", " \n", - " 4\n", + " 6\n", " nh4_ko\n", " glc_ko\n", - " h_e\n", - " 24.191611\n", + " lac__D_e\n", + " 31.460909\n", " \n", " \n", - " 14\n", + " 12\n", " glc_ko\n", " nh4_ko\n", - " acald_e\n", - " 19.267934\n", + " pyr_e\n", + " 31.254737\n", " \n", " \n", " 13\n", " nh4_ko\n", " glc_ko\n", " ac_e\n", - " 15.019305\n", + " 23.866599\n", " \n", " \n", - " 6\n", + " 4\n", " nh4_ko\n", " glc_ko\n", - " lac__D_e\n", - " 7.133330\n", + " h_e\n", + " 23.679204\n", + " \n", + " \n", + " 18\n", + " glc_ko\n", + " nh4_ko\n", + " etoh_e\n", + " 9.979772\n", + " \n", + " \n", + " 14\n", + " glc_ko\n", + " nh4_ko\n", + " acald_e\n", + " 8.736784\n", " \n", " \n", " 15\n", " nh4_ko\n", " glc_ko\n", " akg_e\n", - " 4.717029\n", + " 4.689488\n", " \n", " \n", " 1\n", " glc_ko\n", " nh4_ko\n", " glu__L_e\n", - " 4.668824\n", + " 4.610779\n", " \n", " \n", - " 12\n", - " nh4_ko\n", + " 2\n", " glc_ko\n", - " pyr_e\n", - " 2.280013\n", + " nh4_ko\n", + " h2o_e\n", + " 2.254232\n", " \n", " \n", "\n", @@ -1692,16 +1861,18 @@ ], "text/plain": [ " donor receiver compound rate\n", - "4 nh4_ko glc_ko h_e 24.191611\n", - "14 glc_ko nh4_ko acald_e 19.267934\n", - "13 nh4_ko glc_ko ac_e 15.019305\n", - "6 nh4_ko glc_ko lac__D_e 7.133330\n", - "15 nh4_ko glc_ko akg_e 4.717029\n", - "1 glc_ko nh4_ko glu__L_e 4.668824\n", - "12 nh4_ko glc_ko pyr_e 2.280013" + "6 nh4_ko glc_ko lac__D_e 31.460909\n", + "12 glc_ko nh4_ko pyr_e 31.254737\n", + "13 nh4_ko glc_ko ac_e 23.866599\n", + "4 nh4_ko glc_ko h_e 23.679204\n", + "18 glc_ko nh4_ko etoh_e 9.979772\n", + "14 glc_ko nh4_ko acald_e 8.736784\n", + "15 nh4_ko glc_ko akg_e 4.689488\n", + "1 glc_ko nh4_ko glu__L_e 4.610779\n", + "2 glc_ko nh4_ko h2o_e 2.254232" ] }, - "execution_count": 24, + "execution_count": 56, "metadata": {}, "output_type": "execute_result" } @@ -1720,7 +1891,7 @@ }, { "cell_type": "code", - "execution_count": 25, + "execution_count": 57, "id": "26e96715", "metadata": { "scrolled": true @@ -1736,12 +1907,12 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "230782084e754a1aadcbade5958ebf54", + "model_id": "a40371b628c64825bd06083b3c00733b", "version_major": 2, "version_minor": 0 }, "text/plain": [ - "Builder(reaction_data={'ACALD': -19.267933674315827, 'ACALDt': -19.267933674315827, 'ACKr': 15.019304841008928…" + "Builder(reaction_data={'ACALD': -18.71655537485597, 'ACALDt': -8.73678370807742, 'ACKr': 23.86659902629946, 'A…" ] }, "metadata": {}, @@ -1759,7 +1930,7 @@ }, { "cell_type": "code", - "execution_count": 26, + "execution_count": 58, "id": "3fe40d10", "metadata": {}, "outputs": [ @@ -1773,12 +1944,12 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "0e1bc7e3f13c423584d680c0f2426e9d", + "model_id": "843266a908e74bf9942e78d9f8519c65", "version_major": 2, "version_minor": 0 }, "text/plain": [ - "Builder(reaction_data={'ACALD': 19.267933674315827, 'ACALDt': 19.267933674315827, 'ACKr': -15.019304841008928,…" + "Builder(reaction_data={'ACALD': 18.71655537485597, 'ACALDt': 8.73678370807742, 'ACKr': -23.86659902629946, 'AC…" ] }, "metadata": {}, @@ -1805,7 +1976,7 @@ }, { "cell_type": "code", - "execution_count": 27, + "execution_count": 59, "id": "71695f63", "metadata": {}, "outputs": [ @@ -1816,8 +1987,8 @@ "Set parameter FeasibilityTol to value 1e-09\n", "Set parameter OptimalityTol to value 1e-09\n", "Strain\tMin\tMax\n", - "glc_ko\t0.4%\t98.3%\n", - "nh4_ko\t1.7%\t99.6%\n" + "glc_ko\t0.0%\t99.9%\n", + "nh4_ko\t0.1%\t100.0%\n" ] } ], @@ -1850,7 +2021,7 @@ }, { "cell_type": "code", - "execution_count": 28, + "execution_count": 60, "id": "34220805", "metadata": {}, "outputs": [], @@ -1868,19 +2039,19 @@ }, { "cell_type": "code", - "execution_count": 29, + "execution_count": 61, "id": "1c660055", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "objective: 0.828309078247319\n", + "objective: 0.40757209363986224\n", "Status: OPTIMAL\n", - "Method:SimulationMethod.FBA" + "Method:FBA" ] }, - "execution_count": 29, + "execution_count": 61, "metadata": {}, "output_type": "execute_result" } @@ -1894,7 +2065,7 @@ }, { "cell_type": "code", - "execution_count": 30, + "execution_count": 62, "id": "ecb0bce0", "metadata": {}, "outputs": [ @@ -1929,11 +2100,11 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 0.100000\n", + " 0.407572\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 0.728309\n", + " 0.407572\n", " \n", " \n", "\n", @@ -1942,11 +2113,11 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.100000\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.728309" + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" ] }, - "execution_count": 30, + "execution_count": 62, "metadata": {}, "output_type": "execute_result" } @@ -1965,7 +2136,7 @@ }, { "cell_type": "code", - "execution_count": 31, + "execution_count": 63, "id": "7ecc37ca", "metadata": {}, "outputs": [], @@ -1978,10 +2149,18 @@ }, { "cell_type": "code", - "execution_count": 32, + "execution_count": 64, "id": "77f8eed9", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.17it/s]\n" + ] + } + ], "source": [ "sim = community.get_community_model()\n", "sim.set_environmental_conditions(M9)" @@ -1989,7 +2168,7 @@ }, { "cell_type": "code", - "execution_count": 33, + "execution_count": 65, "id": "7d604601", "metadata": {}, "outputs": [ @@ -1997,9 +2176,9 @@ "name": "stdout", "output_type": "stream", "text": [ - "objective: 0.40757209363986213\n", + "objective: 0.40757209363986224\n", "Status: OPTIMAL\n", - "Method:SimulationMethod.FBA\n" + "Method:FBA\n" ] }, { @@ -2050,7 +2229,7 @@ "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" ] }, - "execution_count": 33, + "execution_count": 65, "metadata": {}, "output_type": "execute_result" } @@ -2063,7 +2242,7 @@ }, { "cell_type": "code", - "execution_count": 34, + "execution_count": 66, "id": "6402d86c", "metadata": {}, "outputs": [ @@ -2129,7 +2308,7 @@ "community_growth {'Biomass_glc_ko': -1, 'Biomass_nh4_ko': -1} {} " ] }, - "execution_count": 34, + "execution_count": 66, "metadata": {}, "output_type": "execute_result" } @@ -2148,7 +2327,7 @@ }, { "cell_type": "code", - "execution_count": 35, + "execution_count": 67, "id": "575721c6", "metadata": {}, "outputs": [ @@ -2183,11 +2362,15 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 0.235022\n", + " 0.105388\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 0.587554\n", + " 0.263471\n", + " \n", + " \n", + " community_growth\n", + " 0.105388\n", " \n", " \n", "\n", @@ -2196,18 +2379,19 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.235022\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.587554" + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.105388\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.263471\n", + "community_growth 0.105388" ] }, - "execution_count": 35, + "execution_count": 67, "metadata": {}, "output_type": "execute_result" } ], "source": [ "community.set_abundance({'glc_ko':1,'nh4_ko':2.5})\n", - "sim.simulate().find('BIOMASS')" + "sim.simulate(method='pFBA').find('BIOMASS|growth')" ] }, { @@ -2230,10 +2414,17 @@ }, { "cell_type": "code", - "execution_count": 36, + "execution_count": 68, "id": "45d28b6e", "metadata": {}, "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.22it/s]\n" + ] + }, { "name": "stdout", "output_type": "stream", @@ -2290,7 +2481,7 @@ "nh4_ko {'glc_ko': 1.0}" ] }, - "execution_count": 36, + "execution_count": 68, "metadata": {}, "output_type": "execute_result" } @@ -2309,7 +2500,7 @@ }, { "cell_type": "code", - "execution_count": 37, + "execution_count": 69, "id": "f779b482", "metadata": {}, "outputs": [ @@ -2352,7 +2543,7 @@ " \n", " \n", " glc_ko\n", - " {'ac_e': 0.02, 'acald_e': 0.35, 'akg_e': 0.23,...\n", + " {'ac_e': 0.06, 'acald_e': 0.28, 'akg_e': 0.2, ...\n", " \n", " \n", " nh4_ko\n", @@ -2365,11 +2556,11 @@ "text/plain": [ " Value\n", "Attribute \n", - "glc_ko {'ac_e': 0.02, 'acald_e': 0.35, 'akg_e': 0.23,...\n", + "glc_ko {'ac_e': 0.06, 'acald_e': 0.28, 'akg_e': 0.2, ...\n", "nh4_ko {'ac_e': 0.0, 'acald_e': 0.0, 'akg_e': 0.0, 'c..." ] }, - "execution_count": 37, + "execution_count": 69, "metadata": {}, "output_type": "execute_result" } @@ -2381,16 +2572,16 @@ }, { "cell_type": "code", - "execution_count": 38, + "execution_count": 70, "id": "d6175f02", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "{'ac_e': 0.02,\n", - " 'acald_e': 0.35,\n", - " 'akg_e': 0.23,\n", + "{'ac_e': 0.06,\n", + " 'acald_e': 0.28,\n", + " 'akg_e': 0.2,\n", " 'co2_e': 0.0,\n", " 'etoh_e': 0.17,\n", " 'for_e': 0.0,\n", @@ -2400,17 +2591,17 @@ " 'gln__L_e': 0.0,\n", " 'glu__L_e': 0.0,\n", " 'h_e': 0.05,\n", - " 'h2o_e': 0.07,\n", + " 'h2o_e': 0.09,\n", " 'lac__D_e': 0.24,\n", " 'mal__L_e': 0.0,\n", " 'nh4_e': 1.0,\n", - " 'o2_e': 0.93,\n", + " 'o2_e': 0.94,\n", " 'pi_e': 1.0,\n", - " 'pyr_e': 0.25,\n", + " 'pyr_e': 0.3,\n", " 'succ_e': 0.08}" ] }, - "execution_count": 38, + "execution_count": 70, "metadata": {}, "output_type": "execute_result" } @@ -2421,7 +2612,7 @@ }, { "cell_type": "code", - "execution_count": 39, + "execution_count": 71, "id": "9449a68c", "metadata": {}, "outputs": [ @@ -2450,7 +2641,7 @@ " 'succ_e': 0.0}" ] }, - "execution_count": 39, + "execution_count": 71, "metadata": {}, "output_type": "execute_result" } @@ -2469,7 +2660,7 @@ }, { "cell_type": "code", - "execution_count": 40, + "execution_count": 72, "id": "095e8c80", "metadata": {}, "outputs": [ @@ -2529,7 +2720,7 @@ "nh4_ko {'etoh_e': 1, 'for_e': 1, 'h2o_e': 1, 'pyr_e':..." ] }, - "execution_count": 40, + "execution_count": 72, "metadata": {}, "output_type": "execute_result" } @@ -2549,7 +2740,7 @@ }, { "cell_type": "code", - "execution_count": 41, + "execution_count": 73, "id": "761408d5", "metadata": {}, "outputs": [ @@ -2563,7 +2754,7 @@ "Set parameter OptimalityTol to value 1e-09\n", "Set parameter FeasibilityTol to value 1e-09\n", "Set parameter OptimalityTol to value 1e-09\n", - "1.0\n" + "0.5\n" ] }, { @@ -2597,11 +2788,11 @@ " \n", " \n", " community_medium\n", - " {gln, pi, fru}\n", + " {glc, gln, pi}\n", " \n", " \n", " individual_media\n", - " {'glc_ko': {'gln', 'pi', 'fru'}, 'nh4_ko': {'g...\n", + " {'glc_ko': {'gln', 'h2o', 'acald', 'pi', 'pyr'...\n", " \n", " \n", "\n", @@ -2610,11 +2801,11 @@ "text/plain": [ " Value\n", "Attribute \n", - "community_medium {gln, pi, fru}\n", - "individual_media {'glc_ko': {'gln', 'pi', 'fru'}, 'nh4_ko': {'g..." + "community_medium {glc, gln, pi}\n", + "individual_media {'glc_ko': {'gln', 'h2o', 'acald', 'pi', 'pyr'..." ] }, - "execution_count": 41, + "execution_count": 73, "metadata": {}, "output_type": "execute_result" } @@ -2627,17 +2818,17 @@ }, { "cell_type": "code", - "execution_count": 42, + "execution_count": 74, "id": "2f72f3c5", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "{'fru', 'gln', 'pi'}" + "{'acald', 'gln', 'h2o', 'pi', 'pyr'}" ] }, - "execution_count": 42, + "execution_count": 74, "metadata": {}, "output_type": "execute_result" } @@ -2648,17 +2839,17 @@ }, { "cell_type": "code", - "execution_count": 43, + "execution_count": 75, "id": "d5461666", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "{'fru', 'gln', 'pi'}" + "{'glc', 'gln', 'pi'}" ] }, - "execution_count": 43, + "execution_count": 75, "metadata": {}, "output_type": "execute_result" } diff --git a/src/mewpy/com/com.py b/src/mewpy/com/com.py index 3a818b37..94270b60 100644 --- a/src/mewpy/com/com.py +++ b/src/mewpy/com/com.py @@ -1,5 +1,6 @@ -# Copyright (C) 2019- Centre of Biological Engineering, +# Copyright (C) 2019-2023 Centre of Biological Engineering, # University of Minho, Portugal +# Vitor Pereira 2019- # This program is free software: you can redistribute it and/or modify # it under the terms of the GNU General Public License as published by @@ -29,7 +30,7 @@ from copy import deepcopy from warnings import warn from numpy import inf - +from tqdm import tqdm from typing import Dict, List, Union, TYPE_CHECKING if TYPE_CHECKING: @@ -39,17 +40,20 @@ class CommunityModel: - + EXT_COMP = "e" GROWTH_ID = "community_growth" - - def __init__(self, - models:List[Union["Simulator","Model","CBModel"]], - abundances:List[float]= None, - merge_biomasses:bool=False, - copy_models:bool=False, - add_compartments=False, - flavor:str='reframed'): + + def __init__( + self, + models: List[Union["Simulator", "Model", "CBModel"]], + abundances: List[float] = None, + merge_biomasses: bool = True, + copy_models: bool = False, + add_compartments=True, + balance_exchange=True, + flavor: str = "reframed", + ): """Community Model. :param models: A list of metabolic models. @@ -57,17 +61,17 @@ def __init__(self, Default None. :param merge_biomasses: If a biomass equation is to be build requiring each organism to grow in acordance to a relative abundance. - Default False. + Default True. If no abundance list is provided all organism will have equal abundance. :param add_compartments: If each organism external compartment is to be added - to the community model. Default False. + to the community model. Default True. :param bool copy_models: if the models are to be copied, default True. :param str flavor: use 'cobrapy' or 'reframed. Default 'reframed'. """ self.organisms = AttrDict() self.model_ids = list({model.id for model in models}) self.flavor = flavor - + self.organisms_biomass = None self.organisms_biomass_metabolite = None self.biomass = None @@ -75,11 +79,16 @@ def __init__(self, self.reaction_map = None self.metabolite_map = None self.gene_map = None - + self.ext_mets = None + self._reverse_map = None + if abundances and any(e <= 0 for e in abundances): + raise ValueError("All abundances need to be positive") + self._merge_biomasses = True if abundances is not None else merge_biomasses self._add_compartments = add_compartments - + self._balance_exchange = balance_exchange + if len(self.model_ids) < len(models): warn("Model ids are not unique, repeated models will be discarded.") @@ -88,26 +97,29 @@ def __init__(self, if not m.objective: raise ValueError(f"Model {m.id} has no objective") self.organisms[m.id] = deepcopy(m) if copy_models else m - + if self._merge_biomasses: - if abundances and len(abundances)==len(self.organisms): - self.organisms_abundance =dict(zip(self.organisms.keys(),abundances)) - else: - self.organisms_abundance = {org_id:1 for org_id in self.organisms.keys()} - - self._comm_model=None - + if abundances and len(abundances) == len(self.organisms): + self.organisms_abundance = dict(zip(self.organisms.keys(), abundances)) + else: + self.organisms_abundance = { + org_id: 1 for org_id in self.organisms.keys() + } + + self._comm_model = None + def init_model(self): - sid = ' '.join(sorted(self.model_ids)) - if self.flavor == 'reframed': + sid = " ".join(sorted(self.model_ids)) + if self.flavor == "reframed": from reframed.core.cbmodel import CBModel + model = CBModel(sid) else: from cobra.core.model import Model + model = Model(sid) self._comm_model = get_simulator(model) - - + def clear(self): self.organisms_biomass = None self.organisms_biomass_metabolite = None @@ -115,69 +127,96 @@ def clear(self): self.reaction_map = None self.metabolite_map = None self.gene_map = None + self.ext_mets = None self._reverse_map = None self._comm_model = None - + @property def add_compartments(self): return self._add_compartments - + @add_compartments.setter - def add_compartments(self,value:bool): + def add_compartments(self, value: bool): if self._add_compartments == value: pass else: self._add_compartments = value self.clear() - + @property def merge_biomasses(self): return self._merge_biomasses - + @merge_biomasses.setter - def merge_biomasses(self,value:bool): + def merge_biomasses(self, value: bool): if self._merge_biomasses == value: pass else: self._merge_biomasses = value self.clear() - + @property def reverse_map(self): if self._reverse_map is not None: return self._reverse_map else: self._reverse_map = dict() - self._reverse_map.update({v:k for k,v in self.reaction_map.items()}) - self._reverse_map.update({v:k for k,v in self.gene_map.items()}) - + self._reverse_map.update({v: k for k, v in self.reaction_map.items()}) + self._reverse_map.update({v: k for k, v in self.gene_map.items()}) + return self._reverse_map + def get_organisms_biomass(self): return self.organisms_biomass - - def set_abundance(self,abundances:Dict[str,float],rebuild=False): + + def set_abundance(self, abundances: Dict[str, float], rebuild=False): if not self._merge_biomasses: raise ValueError("The community model has no merged biomass equation") - self.organisms_abundance.update(abundances) - if any([x<0 for x in abundances.values()]): + if any([x < 0 for x in abundances.values()]): raise ValueError("All abundance value need to be non negative.") - if sum(list(abundances.values()))==0: + if sum(list(abundances.values())) == 0: raise ValueError("At leat one organism need to have a positive abundance.") # update the biomass equation + self.organisms_abundance.update(abundances) if rebuild: self.clear() self._merge_models() else: comm_growth = CommunityModel.GROWTH_ID - biomass_stoichiometry = {met: -self.organisms_abundance[org_id] - for org_id, met in self.organisms_biomass_metabolite.items() - if self.organisms_abundance[org_id]>0 - } - self._comm_model.add_reaction(comm_growth, - name="Community growth rate", - stoichiometry=biomass_stoichiometry, - lb=0, ub=inf, reaction_type='SINK') + biomass_stoichiometry = { + met: -self.organisms_abundance[org_id] + for org_id, met in self.organisms_biomass_metabolite.items() + if self.organisms_abundance[org_id] > 0 + } + self._comm_model.add_reaction( + comm_growth, + name="Community growth rate", + stoichiometry=biomass_stoichiometry, + lb=0, + ub=inf, + reaction_type="SINK", + ) self._comm_model.objective = comm_growth - self._comm_model.solver=None + self._comm_model.solver = None + + if self._balance_exchange: + self._update_exchanges() + + def _update_exchanges(self): + if self.merged_model and self._merge_biomasses and self._balance_exchange: + exchange = self.merged_model.get_exchange_reactions() + m_r = self.merged_model.metabolite_reaction_lookup() + for met in self.ext_mets: + rxns = m_r[met] + for rx,st in rxns.items(): + if rx in exchange: + continue + org = self.reverse_map[rx][0] + ab = self.organisms_abundance[org] + rxn = self.merged_model.get_reaction(rx) + stch = rxn.stoichiometry + new_stch = stch.copy() + new_stch[met] = ab if st > 0 else -ab + self.merged_model.update_stoichiometry(rx, new_stch) def get_community_model(self): """Returns a Simulator for the merged model""" @@ -185,30 +224,30 @@ def get_community_model(self): def size(self): return len(self.organisms) - - def get_organisms_biomass(self)->Dict[str,str]: + + def get_organisms_biomass(self) -> Dict[str, str]: return self.organisms_biomass @property def merged_model(self): - """ Returns a community model (COBRApy or REFRAMED)""" + """Returns a community model (COBRApy or REFRAMED)""" if self._comm_model is None: self._merge_models() return self._comm_model def _merge_models(self): """Merges the models.""" - + self.init_model() - + old_ext_comps = [] - ext_mets = [] + self.ext_mets = [] self.organisms_biomass = {} self.reaction_map = {} self.metabolite_map = {} self.gene_map = {} self._reverse_map = None - + if self._merge_biomasses: self.organisms_biomass_metabolite = {} @@ -217,19 +256,19 @@ def _merge_models(self): comm_growth = CommunityModel.GROWTH_ID # create external compartment - self._comm_model.add_compartment(ext_comp_id, - "extracellular environment", - external=True) + self._comm_model.add_compartment( + ext_comp_id, "extracellular environment", external=True + ) # community biomass if not self._merge_biomasses: biomass_id = "community_biomass" - self._comm_model.add_metabolite(biomass_id, - name="Total community biomass", - compartment=ext_comp_id) + self._comm_model.add_metabolite( + biomass_id, name="Total community biomass", compartment=ext_comp_id + ) # add each organism - for org_id, model in self.organisms.items(): + for org_id, model in tqdm(self.organisms.items(), "Organism"): def rename(old_id): return f"{old_id}_{org_id}" @@ -238,21 +277,21 @@ def r_gene(old_id, organism=True): if model._g_prefix == self._comm_model._g_prefix: _id = old_id else: - _id = self._comm_model._g_prefix+old_id[len(model._g_prefix):] + _id = self._comm_model._g_prefix + old_id[len(model._g_prefix) :] return rename(_id) if organism else _id def r_met(old_id, organism=True): if model._m_prefix == self._comm_model._m_prefix: _id = old_id else: - _id = self._comm_model._m_prefix+old_id[len(model._m_prefix):] + _id = self._comm_model._m_prefix + old_id[len(model._m_prefix) :] return rename(_id) if organism else _id def r_rxn(old_id, organism=True): if model._r_prefix == self._comm_model._r_prefix: _id = old_id else: - _id = self._comm_model._r_prefix+old_id[len(model._r_prefix):] + _id = self._comm_model._r_prefix + old_id[len(model._r_prefix) :] return rename(_id) if organism else _id # add internal compartments @@ -261,108 +300,125 @@ def r_rxn(old_id, organism=True): if comp.external: old_ext_comps.append(c_id) if not self._add_compartments: - continue - self._comm_model.add_compartment(rename(c_id), name=f"{comp.name} ({org_id})") - + continue + self._comm_model.add_compartment( + rename(c_id), name=f"{comp.name} ({org_id})" + ) + # add metabolites for m_id in model.metabolites: met = model.get_metabolite(m_id) if met.compartment not in old_ext_comps or self._add_compartments: new_mid = r_met(m_id) - self._comm_model.add_metabolite(new_mid, - formula=met.formula, - name=met.name, - compartment=rename(met.compartment) - ) + self._comm_model.add_metabolite( + new_mid, + formula=met.formula, + name=met.name, + compartment=rename(met.compartment), + ) self.metabolite_map[(org_id, m_id)] = new_mid - - - - if met.compartment in old_ext_comps and r_met(m_id, False) not in self._comm_model.metabolites: + if ( + met.compartment in old_ext_comps + and r_met(m_id, False) not in self._comm_model.metabolites + ): new_mid = r_met(m_id, False) - self._comm_model.add_metabolite(new_mid, - formula=met.formula, - name=met.name, - compartment=ext_comp_id) - ext_mets.append(new_mid) - + self._comm_model.add_metabolite( + new_mid, + formula=met.formula, + name=met.name, + compartment=ext_comp_id, + ) + self.ext_mets.append(new_mid) + # add genes for g_id in model.genes: new_id = r_gene(g_id) - self.gene_map[(org_id,g_id)] = new_id - if self.flavor == 'reframed': + self.gene_map[(org_id, g_id)] = new_id + if self.flavor == "reframed": gene = model.get_gene(g_id) self._comm_model.add_gene(new_id, gene.name) - + # add reactions ex_rxns = model.get_exchange_reactions() - + for r_id in model.reactions: rxn = model.get_reaction(r_id) new_id = r_rxn(r_id) if r_id in ex_rxns: mets = list(rxn.stoichiometry.keys()) - - if self._add_compartments and r_met(mets[0], False) in ext_mets: - new_stoichiometry = {r_met(mets[0]): -1, - r_met(mets[0],False): 1 - } - self._comm_model.add_reaction(new_id, - name=rxn.name, - stoichiometry=new_stoichiometry, - lb=-inf, - ub=inf, - reaction_type='TRP') + + if ( + self._add_compartments + and r_met(mets[0], False) in self.ext_mets + ): + new_stoichiometry = { + r_met(mets[0]): -1, + r_met(mets[0], False): 1, + } + self._comm_model.add_reaction( + new_id, + name=rxn.name, + stoichiometry=new_stoichiometry, + lb=-inf, + ub=inf, + reaction_type="TRP", + ) self.reaction_map[(org_id, r_id)] = new_id - - - elif (len(mets) == 1 - and r_met(mets[0]) in self._comm_model.metabolites): - # some models (e.g. AGORA models) have sink reactions (for biomass) + + elif ( + len(mets) == 1 + and r_met(mets[0]) in self._comm_model.metabolites + ): + # some models (e.g. AGORA models) have sink reactions (for biomass) new_stoichiometry = {r_met(mets[0]): -1} - self._comm_model.add_reaction(new_id, - name=rxn.name, - stoichiometry=new_stoichiometry, - lb=0, - ub=inf, - reaction_type='SINK') + self._comm_model.add_reaction( + new_id, + name=rxn.name, + stoichiometry=new_stoichiometry, + lb=0, + ub=inf, + reaction_type="SINK", + ) self.reaction_map[(org_id, r_id)] = new_id - + else: if self._add_compartments: new_stoichiometry = { r_met(m_id): coeff for m_id, coeff in rxn.stoichiometry.items() - } + } else: new_stoichiometry = { - r_met( m_id, False) if r_met( m_id, False) in ext_mets + r_met(m_id, False) + if r_met(m_id, False) in self.ext_mets else r_met(m_id): coeff for m_id, coeff in rxn.stoichiometry.items() - } - # assumes that the models' objective is the biomass + } + # assumes that the models' objective is the biomass if r_id in [x for x, v in model.objective.items() if v > 0]: if self._merge_biomasses: - met_id = r_met('Biomass') + met_id = r_met("Biomass") self._comm_model.add_metabolite( met_id, name=f"Biomass {org_id}", - compartment=ext_comp_id) - + compartment=ext_comp_id, + ) + new_stoichiometry[met_id] = 1 self.organisms_biomass_metabolite[org_id] = met_id - + # add biomass sink reaction self._comm_model.add_reaction( - r_rxn('Sink_biomass'), + r_rxn("Sink_biomass"), name=f"Sink Biomass {org_id}", - stoichiometry={met_id:-1}, + stoichiometry={met_id: -1}, lb=0, ub=inf, - reaction_type='SINK') - + reaction_type="SINK", + ) + else: new_stoichiometry[biomass_id] = 1 @@ -375,39 +431,62 @@ def r_rxn(old_id, organism=True): else: new_gpr = rxn.gpr - self._comm_model.add_reaction(new_id, - name=rxn.name, - stoichiometry=new_stoichiometry, - lb=rxn.lb, - ub=rxn.ub, - gpr=new_gpr, - annotations=rxn.annotations) + self._comm_model.add_reaction( + new_id, + name=rxn.name, + stoichiometry=new_stoichiometry, + lb=rxn.lb, + ub=rxn.ub, + gpr=new_gpr, + annotations=rxn.annotations, + ) self.reaction_map[(org_id, r_id)] = new_id # Add exchange reactions - for m_id in ext_mets: - m = m_id[len(self._comm_model._m_prefix):] if m_id.startswith(self._comm_model._m_prefix) else m_id + for m_id in self.ext_mets: + m = ( + m_id[len(self._comm_model._m_prefix) :] + if m_id.startswith(self._comm_model._m_prefix) + else m_id + ) r_id = f"{self._comm_model._r_prefix}EX_{m}" - self._comm_model.add_reaction(r_id, name=r_id, stoichiometry={m_id: -1}, lb=-inf, ub=inf, reaction_type="EX") + self._comm_model.add_reaction( + r_id, + name=r_id, + stoichiometry={m_id: -1}, + lb=-inf, + ub=inf, + reaction_type="EX", + ) if self._merge_biomasses: # if the biomasses are to be merged add - # a new product to each organism biomass - biomass_stoichiometry = {met: -1*self.organisms_abundance[org_id] - for org_id, met in self.organisms_biomass_metabolite.items() - } + # a new product to each organism biomass + biomass_stoichiometry = { + met: -1 * self.organisms_abundance[org_id] + for org_id, met in self.organisms_biomass_metabolite.items() + } else: biomass_stoichiometry = {biomass_id: -1} - self._comm_model.add_reaction(comm_growth, name="Community growth rate", - stoichiometry=biomass_stoichiometry, - lb=0, ub=inf, reaction_type='SINK') + self._comm_model.add_reaction( + comm_growth, + name="Community growth rate", + stoichiometry=biomass_stoichiometry, + lb=0, + ub=inf, + reaction_type="SINK", + ) + + if self._balance_exchange: + self._update_exchanges() self._comm_model.objective = comm_growth self._comm_model.biomass_reaction = comm_growth self.biomass = comm_growth - setattr(self._comm_model,'organisms_biomass',self.organisms_biomass) + setattr(self._comm_model, "organisms_biomass", self.organisms_biomass) + setattr(self._comm_model, "community", self) return self._comm_model def copy(self, copy_models=False, flavor=None): diff --git a/src/mewpy/com/regfba.py b/src/mewpy/com/regfba.py index 460b2abc..f6192bfb 100644 --- a/src/mewpy/com/regfba.py +++ b/src/mewpy/com/regfba.py @@ -30,6 +30,9 @@ def regComFBA(cmodel, objective=None, maximize=True, constraints=None, obj_frac= else: sim = get_simulator(cmodel) + if not hasattr(sim, 'community'): + raise Exception('The model does not seem to be a community model') + if not objective: objective = sim.objective if len(objective) == 0: @@ -51,12 +54,11 @@ def regComFBA(cmodel, objective=None, maximize=True, constraints=None, obj_frac= obj_frac * pre_solution.objective_value) solver.update() - - org_bio=list(sim.organisms_biomass.values()) + org_bio=list(sim.community.organisms_biomass.values()) qobjective = {(rid,rid):1 for rid in org_bio} solution = solver.solve(quadratic=qobjective, minimize=True, constraints=constraints) - result = to_simulation_result(sim, solution.fobj, constraints, sim, solution, regComFBA ) + result = to_simulation_result(sim, solution.fobj, constraints, sim, solution, regComFBA) return result diff --git a/src/mewpy/simulation/simulation.py b/src/mewpy/simulation/simulation.py index 0f85351a..142cb62c 100644 --- a/src/mewpy/simulation/simulation.py +++ b/src/mewpy/simulation/simulation.py @@ -58,6 +58,9 @@ def __eq__(self, other): def __hash__(self): return hash(self.name) + + def __str__(self) -> str: + return self.name class SStatus(Enum): diff --git a/src/mewpy/simulation/simulator.py b/src/mewpy/simulation/simulator.py index 533ccf48..d7f625a6 100644 --- a/src/mewpy/simulation/simulator.py +++ b/src/mewpy/simulation/simulator.py @@ -54,7 +54,7 @@ def get_simulator(model, envcond=None, constraints=None, reference=None, reset_s """ # already is a Simulator instance if isinstance(model, Simulator): - return model + return model.copy() instance = None name = f"{model.__class__.__module__}.{model.__class__.__name__}" From 423455936667304c3f19a4b3eb426e4ad54d2203 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 22 Jun 2024 13:20:23 +0100 Subject: [PATCH 03/24] version 0.1.35 --- PKG-INFO | 4 +- README.md | 2 +- README.rst | 29 - examples/08-community.ipynb | 2184 ++--------------------------------- setup.cfg | 7 +- setup.py | 5 +- src/mewpy/__init__.py | 9 +- src/mewpy/com/com.py | 23 +- src/mewpy/com/steadycom.py | 1 + 9 files changed, 115 insertions(+), 2149 deletions(-) delete mode 100644 README.rst diff --git a/PKG-INFO b/PKG-INFO index 31c18a33..dfac1217 100644 --- a/PKG-INFO +++ b/PKG-INFO @@ -1,9 +1,9 @@ Metadata-Version: 2.1 Name: mewpy -Version: 0.1.34 +Version: 0.1.35 Summary: MEWpy - Metabolic Engineering in Python Home-page: https://github.com/BioSystemsUM/mewpy/ -Author: BiSBII CEB University of Minho +Author: Vitor Pereira / BiSBII CEB University of Minho Author-email: vpereira@ceb.uminho.pt License: GPL v3 License Project-URL: Bug Tracker, https://github.com/BioSystemsUM/mewpy/issues diff --git a/README.md b/README.md index c41548ff..fa150ee8 100644 --- a/README.md +++ b/README.md @@ -47,7 +47,7 @@ Vítor Pereira, Fernando Cruz, Miguel Rocha, MEWpy: a computational strain optim ### Credits and License -Developed at Centre of Biological Engineering, University of Minho (2019-2023) and received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 814408. +Developed by Vítor Pereira and Centre of Biological Engineering, University of Minho. MEWpy received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement number 814408 (2019-2023). MEWpy is currently mantained by Vítor Pereira. diff --git a/README.rst b/README.rst deleted file mode 100644 index dd6b7c03..00000000 --- a/README.rst +++ /dev/null @@ -1,29 +0,0 @@ -MEWpy -====== - -MEWpy is an integrated Metabolic Engineering Workbench for strain design optimization. -It offers methods to explore different classes of constraint-based models (CBM) for: - -- Simulation: allows to simulate steady-state metabolic models, considering different formulations (e.g., GECKO, ETFL) and kinetic models; -- Optimization: performs Evolutionary Computation based strain design optimization by knocking out (KO) or over/under expressing (OU) reactions, genes, or enzymes. -- Omics data integration (eFlux, GIMME, iMAT); -- Regulatory networks integration (rFBA, srFBA) - -MEWPy currently supports REFRAMED and COBRApy simulation environments. - -Documentation -------------- - -For documentation and API please check: `https://mewpy.readthedocs.io `_ - -Installation ------------- - -pip install mewpy - - -Credits and License -------------------- - -Developed the Centre of Biological Engineering, University of Minho (2019-2023) and Vítor Pereira - diff --git a/examples/08-community.ipynb b/examples/08-community.ipynb index fa2c1cc2..3cba6449 100644 --- a/examples/08-community.ipynb +++ b/examples/08-community.ipynb @@ -66,9 +66,9 @@ "name": "stdout", "output_type": "stream", "text": [ - "MEWpy version: 0.1.34\n", - "Author: Vitor Pereira (2019-) | CEB University of Minho (2019-2023)\n", - "Contact: vmsapereira@gmail.com \n", + "MEWpy version: 0.1.35\n", + "Author: Vitor Pereira and CEB University of Minho (2019-2023)\n", + "Contact: vpereira@ceb.uminho.pt \n", "\n", "Available LP solvers: gurobi glpk\n", "Default LP solver: gurobi \n", @@ -159,92 +159,15 @@ "metadata": {}, "outputs": [ { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter Username\n", - "Academic license - for non-commercial use only - expires 2024-12-11\n", - "objective: 0.8739215069684301\n", - "Status: OPTIMAL\n", - "Method:FBA\n" + "ename": "ImportError", + "evalue": "cannot import name 'get_simulator' from 'mewpy' (/Users/vpereira/Projects/Python/MEWpy/src/mewpy/__init__.py)", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mImportError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[5], line 2\u001b[0m\n\u001b[1;32m 1\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mcobra\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mio\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m read_sbml_model\n\u001b[0;32m----> 2\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mmewpy\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m get_simulator\n\u001b[1;32m 4\u001b[0m model \u001b[38;5;241m=\u001b[39m read_sbml_model(\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mmodels/ec/e_coli_core.xml.gz\u001b[39m\u001b[38;5;124m'\u001b[39m)\n\u001b[1;32m 5\u001b[0m wildtype \u001b[38;5;241m=\u001b[39m get_simulator(model)\n", + "\u001b[0;31mImportError\u001b[0m: cannot import name 'get_simulator' from 'mewpy' (/Users/vpereira/Projects/Python/MEWpy/src/mewpy/__init__.py)" ] - }, - { - "data": { - "text/html": [ - "
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EX_akg_e_nh4_ko3.390348
EX_co2_e_glc_ko13.294545
EX_co2_e_nh4_ko12.016587
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" - ], - "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "EX_glc__D_e -10.000000\n", - "EX_h2o_e 31.248968\n", - "EX_h_e 16.351792\n", - "EX_nh4_e -4.444818\n", - "EX_o2_e -24.368743\n", - "EX_pi_e -2.998671\n", - "EX_co2_e 25.311132\n", - "EX_glc__D_e_nh4_ko -10.000000\n", - "EX_glu__L_e_glc_ko 2.222409\n", - "EX_glu__L_e_nh4_ko -2.222409\n", - "EX_h2o_e_glc_ko 30.945021\n", - "EX_h2o_e_nh4_ko 0.303946\n", - "EX_h_e_glc_ko -5.029965\n", - "EX_h_e_nh4_ko 21.381758\n", - "EX_lac__D_e_glc_ko -20.076753\n", - "EX_lac__D_e_nh4_ko 20.076753\n", - "EX_nh4_e_glc_ko -4.444818\n", - "EX_o2_e_glc_ko -19.052926\n", - "EX_o2_e_nh4_ko -5.315818\n", - "EX_pi_e_glc_ko -1.499335\n", - "EX_pi_e_nh4_ko -1.499335\n", - "EX_pyr_e_glc_ko 17.017435\n", - "EX_pyr_e_nh4_ko -17.017435\n", - "EX_ac_e_glc_ko -7.810667\n", - "EX_ac_e_nh4_ko 7.810667\n", - "EX_akg_e_glc_ko -3.390348\n", - "EX_akg_e_nh4_ko 3.390348\n", - "EX_co2_e_glc_ko 13.294545\n", - "EX_co2_e_nh4_ko 12.016587" - ] - }, - "execution_count": 47, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "solution = sim.simulate(constraints=M9)\n", "\n", @@ -952,63 +354,10 @@ }, { "cell_type": "code", - "execution_count": 48, + "execution_count": null, "id": "0b5d171f", "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
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" - ], - "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" - ] - }, - "execution_count": 48, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "solution.find('BIOMASS', sort=True,show_nulls=True)" ] @@ -1023,460 +372,20 @@ }, { "cell_type": "code", - "execution_count": 49, + "execution_count": null, "id": "960e9b0b", "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
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namecompartmentformula
id
glc__D_e_glc_koD-Glucosee_glc_koC6H12O6
glc__D_eD-GlucoseeC6H12O6
gln__L_c_glc_koL-Glutaminec_glc_koC5H10N2O3
gln__L_e_glc_koL-Glutaminee_glc_koC5H10N2O3
gln__L_eL-GlutamineeC5H10N2O3
............
fum_c_nh4_koFumaratec_nh4_koC4H2O4
fum_e_nh4_koFumaratee_nh4_koC4H2O4
g3p_c_nh4_koGlyceraldehyde 3-phosphatec_nh4_koC3H5O6P
g6p_c_nh4_koD-Glucose 6-phosphatec_nh4_koC6H11O9P
Biomass_nh4_koBiomass nh4_koeNone
\n", - "

166 rows × 3 columns

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" - ], - "text/plain": [ - " name compartment formula\n", - "id \n", - "glc__D_e_glc_ko D-Glucose e_glc_ko C6H12O6\n", - "glc__D_e D-Glucose e C6H12O6\n", - "gln__L_c_glc_ko L-Glutamine c_glc_ko C5H10N2O3\n", - "gln__L_e_glc_ko L-Glutamine e_glc_ko C5H10N2O3\n", - "gln__L_e L-Glutamine e C5H10N2O3\n", - "... ... ... ...\n", - "fum_c_nh4_ko Fumarate c_nh4_ko C4H2O4\n", - "fum_e_nh4_ko Fumarate e_nh4_ko C4H2O4\n", - "g3p_c_nh4_ko Glyceraldehyde 3-phosphate c_nh4_ko C3H5O6P\n", - "g6p_c_nh4_ko D-Glucose 6-phosphate c_nh4_ko C6H11O9P\n", - "Biomass_nh4_ko Biomass nh4_ko e None\n", - "\n", - "[166 rows x 3 columns]" - ] - }, - "execution_count": 49, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "sim.find_metabolites()" ] }, { "cell_type": "code", - "execution_count": 50, + "execution_count": null, "id": "a69cf655", "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
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Flux rate
Reaction ID
ACKr_nh4_ko-7.810667
ACONTa_nh4_ko1.607668
ACONTb_nh4_ko1.607668
ACt2r_nh4_ko-7.810667
AKGt2r_nh4_ko-3.390348
ATPM_nh4_ko8.390000
ATPS4r_nh4_ko10.578752
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
CO2t_nh4_ko-12.016587
CS_nh4_ko1.607668
CYTBD_nh4_ko10.631636
D_LACt2_nh4_ko-20.076753
ENO_nh4_ko17.707169
FBA_nh4_ko8.994934
G6PDH2r_nh4_ko1.798962
GAPD_nh4_ko18.316897
GLCpts_nh4_ko10.000000
GLNS_nh4_ko0.104216
GLUDy_nh4_ko0.104216
GLUt2r_nh4_ko2.222409
GND_nh4_ko1.798962
H2Ot_nh4_ko-0.303946
ICDHyr_nh4_ko1.607668
LDH_D_nh4_ko-20.076753
NADH16_nh4_ko10.631636
O2t_nh4_ko5.315818
PDH_nh4_ko10.945833
PFK_nh4_ko8.994934
PGI_nh4_ko8.117486
PGK_nh4_ko-18.316897
PGL_nh4_ko1.798962
PGM_nh4_ko-17.707169
PIt2r_nh4_ko1.499335
PPC_nh4_ko2.335877
PTAr_nh4_ko7.810667
PYK_nh4_ko5.159721
PYRt2_nh4_ko17.017435
RPE_nh4_ko0.906345
RPI_nh4_ko-0.892617
TALA_nh4_ko0.526739
TKT1_nh4_ko0.526739
TKT2_nh4_ko0.379606
TPI_nh4_ko8.994934
EX_glc__D_e_nh4_ko-10.000000
EX_glu__L_e_nh4_ko-2.222409
EX_h2o_e_nh4_ko0.303946
EX_h_e_nh4_ko21.381758
EX_lac__D_e_nh4_ko20.076753
EX_o2_e_nh4_ko-5.315818
EX_pi_e_nh4_ko-1.499335
EX_pyr_e_nh4_ko-17.017435
EX_ac_e_nh4_ko7.810667
EX_akg_e_nh4_ko3.390348
EX_co2_e_nh4_ko12.016587
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" - ], - "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "ACKr_nh4_ko -7.810667\n", - "ACONTa_nh4_ko 1.607668\n", - "ACONTb_nh4_ko 1.607668\n", - "ACt2r_nh4_ko -7.810667\n", - "AKGt2r_nh4_ko -3.390348\n", - "ATPM_nh4_ko 8.390000\n", - "ATPS4r_nh4_ko 10.578752\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", - "CO2t_nh4_ko -12.016587\n", - "CS_nh4_ko 1.607668\n", - "CYTBD_nh4_ko 10.631636\n", - "D_LACt2_nh4_ko -20.076753\n", - "ENO_nh4_ko 17.707169\n", - "FBA_nh4_ko 8.994934\n", - "G6PDH2r_nh4_ko 1.798962\n", - "GAPD_nh4_ko 18.316897\n", - "GLCpts_nh4_ko 10.000000\n", - "GLNS_nh4_ko 0.104216\n", - "GLUDy_nh4_ko 0.104216\n", - "GLUt2r_nh4_ko 2.222409\n", - "GND_nh4_ko 1.798962\n", - "H2Ot_nh4_ko -0.303946\n", - "ICDHyr_nh4_ko 1.607668\n", - "LDH_D_nh4_ko -20.076753\n", - "NADH16_nh4_ko 10.631636\n", - "O2t_nh4_ko 5.315818\n", - "PDH_nh4_ko 10.945833\n", - "PFK_nh4_ko 8.994934\n", - "PGI_nh4_ko 8.117486\n", - "PGK_nh4_ko -18.316897\n", - "PGL_nh4_ko 1.798962\n", - "PGM_nh4_ko -17.707169\n", - "PIt2r_nh4_ko 1.499335\n", - "PPC_nh4_ko 2.335877\n", - "PTAr_nh4_ko 7.810667\n", - "PYK_nh4_ko 5.159721\n", - "PYRt2_nh4_ko 17.017435\n", - "RPE_nh4_ko 0.906345\n", - "RPI_nh4_ko -0.892617\n", - "TALA_nh4_ko 0.526739\n", - "TKT1_nh4_ko 0.526739\n", - "TKT2_nh4_ko 0.379606\n", - "TPI_nh4_ko 8.994934\n", - "EX_glc__D_e_nh4_ko -10.000000\n", - "EX_glu__L_e_nh4_ko -2.222409\n", - "EX_h2o_e_nh4_ko 0.303946\n", - "EX_h_e_nh4_ko 21.381758\n", - "EX_lac__D_e_nh4_ko 20.076753\n", - "EX_o2_e_nh4_ko -5.315818\n", - "EX_pi_e_nh4_ko -1.499335\n", - "EX_pyr_e_nh4_ko -17.017435\n", - "EX_ac_e_nh4_ko 7.810667\n", - "EX_akg_e_nh4_ko 3.390348\n", - "EX_co2_e_nh4_ko 12.016587" - ] - }, - "execution_count": 50, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "solution.find('nh4_ko')" ] @@ -1505,7 +414,7 @@ }, { "cell_type": "code", - "execution_count": 51, + "execution_count": null, "id": "c4727cf5", "metadata": {}, "outputs": [], @@ -1515,76 +424,10 @@ }, { "cell_type": "code", - "execution_count": 52, + "execution_count": null, "id": "c80e5339", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "data": { - "text/html": [ - "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
community_growth0.407572
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" - ], - "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", - "community_growth 0.407572" - ] - }, - "execution_count": 52, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "solution = regComFBA(community,constraints=M9,obj_frac=1)\n", "solution.find('BIOMASS|growth', sort=True, show_nulls=True)" @@ -1600,76 +443,10 @@ }, { "cell_type": "code", - "execution_count": 53, + "execution_count": null, "id": "e6698a36", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "data": { - "text/html": [ - "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
community_growth0.407572
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" - ], - "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", - "community_growth 0.407572" - ] - }, - "execution_count": 53, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "solution=sim.simulate(method=regComFBA,constraints=M9,obj_frac=1)\n", "solution.find('BIOMASS|growth', sort=True, show_nulls=True)" @@ -1695,26 +472,10 @@ }, { "cell_type": "code", - "execution_count": 54, + "execution_count": null, "id": "2214667c", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stderr", - "output_type": "stream", - "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.15it/s]\n" - ] - } - ], + "outputs": [], "source": [ "solution = SteadyCom(community, constraints=M9)" ] @@ -1729,23 +490,10 @@ }, { "cell_type": "code", - "execution_count": 55, + "execution_count": null, "id": "50794ba1", "metadata": {}, - "outputs": [ - { - "data": { - "text/plain": [ - "Community growth: 0.027466848121535575\n", - "glc_ko\t1.0\n", - "nh4_ko\t30.785477210087368" - ] - }, - "execution_count": 55, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "solution" ] @@ -1760,123 +508,10 @@ }, { "cell_type": "code", - "execution_count": 56, + "execution_count": null, "id": "e5b8887e", "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
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donorreceivercompoundrate
6nh4_koglc_kolac__D_e31.460909
12glc_konh4_kopyr_e31.254737
13nh4_koglc_koac_e23.866599
4nh4_koglc_koh_e23.679204
18glc_konh4_koetoh_e9.979772
14glc_konh4_koacald_e8.736784
15nh4_koglc_koakg_e4.689488
1glc_konh4_koglu__L_e4.610779
2glc_konh4_koh2o_e2.254232
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" - ], - "text/plain": [ - " donor receiver compound rate\n", - "6 nh4_ko glc_ko lac__D_e 31.460909\n", - "12 glc_ko nh4_ko pyr_e 31.254737\n", - "13 nh4_ko glc_ko ac_e 23.866599\n", - "4 nh4_ko glc_ko h_e 23.679204\n", - "18 glc_ko nh4_ko etoh_e 9.979772\n", - "14 glc_ko nh4_ko acald_e 8.736784\n", - "15 nh4_ko glc_ko akg_e 4.689488\n", - "1 glc_ko nh4_ko glu__L_e 4.610779\n", - "2 glc_ko nh4_ko h2o_e 2.254232" - ] - }, - "execution_count": 56, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "solution.cross_feeding(as_df=True).dropna().sort_values('rate', ascending=False)" ] @@ -1891,34 +526,12 @@ }, { "cell_type": "code", - "execution_count": 57, + "execution_count": null, "id": "26e96715", "metadata": { "scrolled": true }, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Downloading Map from https://escher.github.io/1-0-0/6/maps/Escherichia%20coli/e_coli_core.Core%20metabolism.json\n" - ] - }, - { - "data": { - "application/vnd.jupyter.widget-view+json": { - "model_id": "a40371b628c64825bd06083b3c00733b", - "version_major": 2, - "version_minor": 0 - }, - "text/plain": [ - "Builder(reaction_data={'ACALD': -18.71655537485597, 'ACALDt': -8.73678370807742, 'ACKr': 23.86659902629946, 'A…" - ] - }, - "metadata": {}, - "output_type": "display_data" - } - ], + "outputs": [], "source": [ "from mewpy.visualization.escher import build_escher\n", "if 'google.colab' in str(get_ipython()):\n", @@ -1930,32 +543,10 @@ }, { "cell_type": "code", - "execution_count": 58, + "execution_count": null, "id": "3fe40d10", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Downloading Map from https://escher.github.io/1-0-0/6/maps/Escherichia%20coli/e_coli_core.Core%20metabolism.json\n" - ] - }, - { - "data": { - "application/vnd.jupyter.widget-view+json": { - "model_id": "843266a908e74bf9942e78d9f8519c65", - "version_major": 2, - "version_minor": 0 - }, - "text/plain": [ - "Builder(reaction_data={'ACALD': 18.71655537485597, 'ACALDt': 8.73678370807742, 'ACKr': -23.86659902629946, 'AC…" - ] - }, - "metadata": {}, - "output_type": "display_data" - } - ], + "outputs": [], "source": [ "build_escher(fluxes=solution.internal['nh4_ko'])" ] @@ -1976,22 +567,10 @@ }, { "cell_type": "code", - "execution_count": 59, + "execution_count": null, "id": "71695f63", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Strain\tMin\tMax\n", - "glc_ko\t0.0%\t99.9%\n", - "nh4_ko\t0.1%\t100.0%\n" - ] - } - ], + "outputs": [], "source": [ "from mewpy.com import SteadyComVA\n", "variability = SteadyComVA(community, obj_frac=0.9, constraints=M9)\n", @@ -2021,7 +600,7 @@ }, { "cell_type": "code", - "execution_count": 60, + "execution_count": null, "id": "34220805", "metadata": {}, "outputs": [], @@ -2039,23 +618,10 @@ }, { "cell_type": "code", - "execution_count": 61, + "execution_count": null, "id": "1c660055", "metadata": {}, - "outputs": [ - { - "data": { - "text/plain": [ - "objective: 0.40757209363986224\n", - "Status: OPTIMAL\n", - "Method:FBA" - ] - }, - "execution_count": 61, - "metadata": {}, - "output_type": "execute_result" - } - ], + "outputs": [], "source": [ "constraints={community.organisms_biomass['nh4_ko']:(0.1,1000), \n", " community.organisms_biomass['glc_ko']:(0.1,1000)}\n", @@ -2065,63 +631,10 @@ }, { "cell_type": "code", - "execution_count": 62, + "execution_count": null, "id": "ecb0bce0", "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
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Flux rate
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BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
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namelbubstoichiometrygprannotations
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community_growthCommunity growth rate0inf{'Biomass_glc_ko': -1, 'Biomass_nh4_ko': -1}{}
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.105388
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.263471
community_growth0.105388
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Value
Attribute
glc_ko{'nh4_ko': 1.0}
nh4_ko{'glc_ko': 1.0}
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Value
Attribute
glc_ko{'ac_e': 0.06, 'acald_e': 0.28, 'akg_e': 0.2, ...
nh4_ko{'ac_e': 0.0, 'acald_e': 0.0, 'akg_e': 0.0, 'c...
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Value
Attribute
glc_ko{'etoh_e': 1, 'for_e': 1, 'h2o_e': 1, 'pyr_e':...
nh4_ko{'etoh_e': 1, 'for_e': 1, 'h2o_e': 1, 'pyr_e':...
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Value
Attribute
community_medium{glc, gln, pi}
individual_media{'glc_ko': {'gln', 'h2o', 'acald', 'pi', 'pyr'...
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} - ], + "outputs": [], "source": [ "MRO.individual_media.nh4_ko" ] diff --git a/setup.cfg b/setup.cfg index 57c4f6e0..98f9d0b3 100644 --- a/setup.cfg +++ b/setup.cfg @@ -1,18 +1,17 @@ [bumpversion] -current_version = 0.1.34 +current_version = 0.1.35 commit = True tag = False [metadata] name = MEWpy -author = Vitor Pereira -author_email = vpereira@ceb.uminho.pt +author = Vitor Pereira and BiSBII CEB University of Minho description = Metabolic Enginneering Workbench long_description = file: README.md long_description_content_type = text/markdown url = https://github.com/BioSystemsUM/mewpy project_urls = - Bug Tracker = https://github.com/BioSystemsUM/mewpy/issues + Development = https://github.com/vmspereira/MEWpy Documentation = https://mewpy.readthedocs.io classifiers = Programming Language :: Python :: 3 diff --git a/setup.py b/setup.py index d0db4b47..ceca4c45 100644 --- a/setup.py +++ b/setup.py @@ -15,7 +15,7 @@ setup( name='mewpy', - version='0.1.34', + version='0.1.35', python_requires='>=3.6', package_dir={'': 'src'}, packages=find_packages('src'), @@ -25,8 +25,7 @@ install_requires=install_requirements, setup_requires=setup_requirements, tests_require=test_requirements, - author='BiSBII CEB University of Minho', - author_email='vpereira@ceb.uminho.pt', + author='Vitor Pereira and BiSBII CEB University of Minho', description='MEWpy - Metabolic Engineering in Python ', license='GPL v3 License', keywords='strain optimization', diff --git a/src/mewpy/__init__.py b/src/mewpy/__init__.py index 03b431d4..55b758e4 100644 --- a/src/mewpy/__init__.py +++ b/src/mewpy/__init__.py @@ -1,6 +1,3 @@ -# Copyright (C) 2019- Centre of Biological Engineering, -# University of Minho, Portugal - # This program is free software: you can redistribute it and/or modify # it under the terms of the GNU General Public License as published by # the Free Software Foundation, either version 3 of the License, or @@ -16,9 +13,9 @@ from .simulation import get_simulator -__author__ = 'Vitor Pereira (2019-) | CEB University of Minho (2019-2023)' -__email__ = 'vmsapereira@gmail.com' -__version__ = '0.1.34' +__author__ = 'Vitor Pereira and CEB University of Minho (2019-2023)' +__email__ = 'vpereira@ceb.uminho.pt' +__version__ = '0.1.35' diff --git a/src/mewpy/com/com.py b/src/mewpy/com/com.py index 94270b60..a28a044d 100644 --- a/src/mewpy/com/com.py +++ b/src/mewpy/com/com.py @@ -70,6 +70,8 @@ def __init__( """ self.organisms = AttrDict() self.model_ids = list({model.id for model in models}) + if len(self.model_ids)!= len(set(self.model_ids)): + raise ValueError('Each model must have a different ID.') self.flavor = flavor self.organisms_biomass = None @@ -143,6 +145,20 @@ def add_compartments(self, value: bool): self._add_compartments = value self.clear() + @property + def balance_exchanges(self): + return self._balance_exchange + + @balance_exchanges.setter + def balance_exchanges(self, value: bool): + if value == self._balance_exchange: + return + self._balance_exchange = value + if value: + self._update_exchanges() + else: + self._update_exchanges({k:1 for k in self.model_ids}) + @property def merge_biomasses(self): return self._merge_biomasses @@ -201,7 +217,7 @@ def set_abundance(self, abundances: Dict[str, float], rebuild=False): if self._balance_exchange: self._update_exchanges() - def _update_exchanges(self): + def _update_exchanges(self,abundances:dict=None): if self.merged_model and self._merge_biomasses and self._balance_exchange: exchange = self.merged_model.get_exchange_reactions() m_r = self.merged_model.metabolite_reaction_lookup() @@ -211,7 +227,10 @@ def _update_exchanges(self): if rx in exchange: continue org = self.reverse_map[rx][0] - ab = self.organisms_abundance[org] + if abundances: + ab = abundances[org] + else: + ab = self.organisms_abundance[org] rxn = self.merged_model.get_reaction(rx) stch = rxn.stoichiometry new_stch = stch.copy() diff --git a/src/mewpy/com/steadycom.py b/src/mewpy/com/steadycom.py index ff21848d..91f5cc9d 100644 --- a/src/mewpy/com/steadycom.py +++ b/src/mewpy/com/steadycom.py @@ -40,6 +40,7 @@ def SteadyCom(community, constraints=None, solver=None): # set the proper community building configuration community.add_compartments = False community.merged_biomasses = False + community.balance_exchanges = False if solver is None: solver = build_problem(community) From 550b66bfc16f43bb26d10c7ea51ef3fca96904b8 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 22 Jun 2024 13:57:21 +0100 Subject: [PATCH 04/24] Update README --- README.md | 4 ++-- setup.py | 4 ---- 2 files changed, 2 insertions(+), 6 deletions(-) diff --git a/README.md b/README.md index fa150ee8..74ae6e44 100644 --- a/README.md +++ b/README.md @@ -15,7 +15,7 @@ MEWPy currently supports [REFRAMED](https://github.com/cdanielmachado/reframed) ## Examples -Examples are provided as [jupyter notebooks](examples) and as [python scripts](examples). +Examples are provided as [jupyter notebooks](https://github.com/vmspereira/MEWpy/tree/vpereira/dev/examples) and as [python scripts](https://github.com/vmspereira/MEWpy/tree/vpereira/dev/examples/scripts). ## Documentation @@ -31,7 +31,7 @@ Installing from github: 1. clone the repository -`git clone https://github.com/BioSystemsUM/mewpy.git -b master` +`git clone https://github.com/vmspereira/MEWpy.git -b master` 2. run `python setup.py install` diff --git a/setup.py b/setup.py index ceca4c45..e352820b 100644 --- a/setup.py +++ b/setup.py @@ -2,9 +2,6 @@ files = ["model/data/*"] -with open('README.rst') as readme_file: - readme = readme_file.read() - requirements = ['cobra', 'inspyred', 'jmetalpy<=1.5.5', 'reframed', 'networkx', 'matplotlib<=3.5.0', 'joblib', 'tdqm', 'httpx<=0.23.0'] @@ -30,6 +27,5 @@ license='GPL v3 License', keywords='strain optimization', url='https://github.com/BioSystemsUM/mewpy/', - long_description=readme, test_suite='tests', ) From 02961640dad4c3a9111234870c2905408a53acb2 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 22 Jun 2024 15:45:12 +0100 Subject: [PATCH 05/24] Update workflow --- .github/workflows/main.yaml | 8 +++----- 1 file changed, 3 insertions(+), 5 deletions(-) diff --git a/.github/workflows/main.yaml b/.github/workflows/main.yaml index 8261287a..38e53524 100644 --- a/.github/workflows/main.yaml +++ b/.github/workflows/main.yaml @@ -3,13 +3,13 @@ name: CI-CD on: push: branches: - - devel + - dev tags: - '[0-9]+.[0-9]+.[0-9]+' - '[0-9]+.[0-9]+.[0-9]+a[0-9]+' pull_request: branches: - - devel + - dev jobs: test: @@ -33,6 +33,4 @@ jobs: - name: Test with tox run: tox -e py - - name: Report coverage - shell: bash - run: bash <(curl -s https://codecov.io/bash) \ No newline at end of file + \ No newline at end of file From 81c5abfda76f8ab028641313ce33882856443ce7 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Mon, 24 Jun 2024 12:28:04 +0100 Subject: [PATCH 06/24] Update notebooks --- examples/08-community.ipynb | 2356 +++++++- examples/09-crossfeeding.ipynb | 9851 +++++++++++++++++++++++++++++--- 2 files changed, 11197 insertions(+), 1010 deletions(-) diff --git a/examples/08-community.ipynb b/examples/08-community.ipynb index 3cba6449..aa4f4827 100644 --- a/examples/08-community.ipynb +++ b/examples/08-community.ipynb @@ -159,15 +159,92 @@ "metadata": {}, "outputs": [ { - "ename": "ImportError", - "evalue": "cannot import name 'get_simulator' from 'mewpy' (/Users/vpereira/Projects/Python/MEWpy/src/mewpy/__init__.py)", - "output_type": "error", - "traceback": [ - "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", - "\u001b[0;31mImportError\u001b[0m Traceback (most recent call last)", - "Cell \u001b[0;32mIn[5], line 2\u001b[0m\n\u001b[1;32m 1\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mcobra\u001b[39;00m\u001b[38;5;21;01m.\u001b[39;00m\u001b[38;5;21;01mio\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m read_sbml_model\n\u001b[0;32m----> 2\u001b[0m \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01mmewpy\u001b[39;00m \u001b[38;5;28;01mimport\u001b[39;00m get_simulator\n\u001b[1;32m 4\u001b[0m model \u001b[38;5;241m=\u001b[39m read_sbml_model(\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mmodels/ec/e_coli_core.xml.gz\u001b[39m\u001b[38;5;124m'\u001b[39m)\n\u001b[1;32m 5\u001b[0m wildtype \u001b[38;5;241m=\u001b[39m get_simulator(model)\n", - "\u001b[0;31mImportError\u001b[0m: cannot import name 'get_simulator' from 'mewpy' (/Users/vpereira/Projects/Python/MEWpy/src/mewpy/__init__.py)" + "name": "stdout", + "output_type": "stream", + "text": [ + "Set parameter Username\n", + "Academic license - for non-commercial use only - expires 2024-12-11\n", + "objective: 0.8739215069684301\n", + "Status: OPTIMAL\n", + "Method:FBA\n" ] + }, + { + "data": { + "text/html": [ + "
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EX_succ_e0.01000.0
" + ], + "text/plain": [ + "EX_ac_e\t0.0\t1000.0\n", + "EX_acald_e\t0.0\t1000.0\n", + "EX_akg_e\t0.0\t1000.0\n", + "EX_co2_e\t-1000.0\t1000.0\n", + "EX_etoh_e\t0.0\t1000.0\n", + "EX_for_e\t0.0\t1000.0\n", + "EX_fru_e\t0.0\t1000.0\n", + "EX_fum_e\t0.0\t1000.0\n", + "EX_glc__D_e\t-10.0\t1000.0\n", + "EX_gln__L_e\t0.0\t1000.0\n", + "EX_glu__L_e\t0.0\t1000.0\n", + "EX_h_e\t-1000.0\t1000.0\n", + "EX_h2o_e\t-1000.0\t1000.0\n", + "EX_lac__D_e\t0.0\t1000.0\n", + "EX_mal__L_e\t0.0\t1000.0\n", + "EX_nh4_e\t-1000.0\t1000.0\n", + "EX_o2_e\t-1000.0\t1000.0\n", + "EX_pi_e\t-1000.0\t1000.0\n", + "EX_pyr_e\t0.0\t1000.0\n", + "EX_succ_e\t0.0\t1000.0" + ] + }, + "execution_count": 14, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "from mewpy.simulation import Environment\n", "M9 = Environment.from_model(wildtype)\n", @@ -329,10 +783,207 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 15, "id": "47cb7a4b", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "objective: 0.40757209363986224\n", + "Status: OPTIMAL\n", + "Method:FBA\n" + ] + }, + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
EX_glc__D_e-10.000000
EX_h2o_e31.248968
EX_h_e16.351792
EX_nh4_e-4.444818
EX_o2_e-24.368743
EX_pi_e-2.998671
EX_co2_e25.311132
EX_glc__D_e_nh4_ko-10.000000
EX_glu__L_e_glc_ko2.222409
EX_glu__L_e_nh4_ko-2.222409
EX_h2o_e_glc_ko30.945021
EX_h2o_e_nh4_ko0.303946
EX_h_e_glc_ko-5.029965
EX_h_e_nh4_ko21.381758
EX_lac__D_e_glc_ko-20.076753
EX_lac__D_e_nh4_ko20.076753
EX_nh4_e_glc_ko-4.444818
EX_o2_e_glc_ko-19.052926
EX_o2_e_nh4_ko-5.315818
EX_pi_e_glc_ko-1.499335
EX_pi_e_nh4_ko-1.499335
EX_pyr_e_glc_ko17.017435
EX_pyr_e_nh4_ko-17.017435
EX_ac_e_glc_ko-7.810667
EX_ac_e_nh4_ko7.810667
EX_akg_e_glc_ko-3.390348
EX_akg_e_nh4_ko3.390348
EX_co2_e_glc_ko13.294545
EX_co2_e_nh4_ko12.016587
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "EX_glc__D_e -10.000000\n", + "EX_h2o_e 31.248968\n", + "EX_h_e 16.351792\n", + "EX_nh4_e -4.444818\n", + "EX_o2_e -24.368743\n", + "EX_pi_e -2.998671\n", + "EX_co2_e 25.311132\n", + "EX_glc__D_e_nh4_ko -10.000000\n", + "EX_glu__L_e_glc_ko 2.222409\n", + "EX_glu__L_e_nh4_ko -2.222409\n", + "EX_h2o_e_glc_ko 30.945021\n", + "EX_h2o_e_nh4_ko 0.303946\n", + "EX_h_e_glc_ko -5.029965\n", + "EX_h_e_nh4_ko 21.381758\n", + "EX_lac__D_e_glc_ko -20.076753\n", + "EX_lac__D_e_nh4_ko 20.076753\n", + "EX_nh4_e_glc_ko -4.444818\n", + "EX_o2_e_glc_ko -19.052926\n", + "EX_o2_e_nh4_ko -5.315818\n", + "EX_pi_e_glc_ko -1.499335\n", + "EX_pi_e_nh4_ko -1.499335\n", + "EX_pyr_e_glc_ko 17.017435\n", + "EX_pyr_e_nh4_ko -17.017435\n", + "EX_ac_e_glc_ko -7.810667\n", + "EX_ac_e_nh4_ko 7.810667\n", + "EX_akg_e_glc_ko -3.390348\n", + "EX_akg_e_nh4_ko 3.390348\n", + "EX_co2_e_glc_ko 13.294545\n", + "EX_co2_e_nh4_ko 12.016587" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution = sim.simulate(constraints=M9)\n", "\n", @@ -354,10 +1005,63 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 16, "id": "0b5d171f", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" + ] + }, + "execution_count": 16, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution.find('BIOMASS', sort=True,show_nulls=True)" ] @@ -372,20 +1076,460 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 17, "id": "960e9b0b", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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namecompartmentformula
id
glc__D_e_glc_koD-Glucosee_glc_koC6H12O6
glc__D_eD-GlucoseeC6H12O6
gln__L_c_glc_koL-Glutaminec_glc_koC5H10N2O3
gln__L_e_glc_koL-Glutaminee_glc_koC5H10N2O3
gln__L_eL-GlutamineeC5H10N2O3
............
fum_c_nh4_koFumaratec_nh4_koC4H2O4
fum_e_nh4_koFumaratee_nh4_koC4H2O4
g3p_c_nh4_koGlyceraldehyde 3-phosphatec_nh4_koC3H5O6P
g6p_c_nh4_koD-Glucose 6-phosphatec_nh4_koC6H11O9P
Biomass_nh4_koBiomass nh4_koeNone
\n", + "

166 rows × 3 columns

\n", + "
" + ], + "text/plain": [ + " name compartment formula\n", + "id \n", + "glc__D_e_glc_ko D-Glucose e_glc_ko C6H12O6\n", + "glc__D_e D-Glucose e C6H12O6\n", + "gln__L_c_glc_ko L-Glutamine c_glc_ko C5H10N2O3\n", + "gln__L_e_glc_ko L-Glutamine e_glc_ko C5H10N2O3\n", + "gln__L_e L-Glutamine e C5H10N2O3\n", + "... ... ... ...\n", + "fum_c_nh4_ko Fumarate c_nh4_ko C4H2O4\n", + "fum_e_nh4_ko Fumarate e_nh4_ko C4H2O4\n", + "g3p_c_nh4_ko Glyceraldehyde 3-phosphate c_nh4_ko C3H5O6P\n", + "g6p_c_nh4_ko D-Glucose 6-phosphate c_nh4_ko C6H11O9P\n", + "Biomass_nh4_ko Biomass nh4_ko e None\n", + "\n", + "[166 rows x 3 columns]" + ] + }, + "execution_count": 17, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "sim.find_metabolites()" ] }, { "cell_type": "code", - "execution_count": null, + "execution_count": 18, "id": "a69cf655", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
ACKr_nh4_ko-7.810667
ACONTa_nh4_ko1.607668
ACONTb_nh4_ko1.607668
ACt2r_nh4_ko-7.810667
AKGt2r_nh4_ko-3.390348
ATPM_nh4_ko8.390000
ATPS4r_nh4_ko10.578752
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
CO2t_nh4_ko-12.016587
CS_nh4_ko1.607668
CYTBD_nh4_ko10.631636
D_LACt2_nh4_ko-20.076753
ENO_nh4_ko17.707169
FBA_nh4_ko8.994934
G6PDH2r_nh4_ko1.798962
GAPD_nh4_ko18.316897
GLCpts_nh4_ko10.000000
GLNS_nh4_ko0.104216
GLUDy_nh4_ko0.104216
GLUt2r_nh4_ko2.222409
GND_nh4_ko1.798962
H2Ot_nh4_ko-0.303946
ICDHyr_nh4_ko1.607668
LDH_D_nh4_ko-20.076753
NADH16_nh4_ko10.631636
O2t_nh4_ko5.315818
PDH_nh4_ko10.945833
PFK_nh4_ko8.994934
PGI_nh4_ko8.117486
PGK_nh4_ko-18.316897
PGL_nh4_ko1.798962
PGM_nh4_ko-17.707169
PIt2r_nh4_ko1.499335
PPC_nh4_ko2.335877
PTAr_nh4_ko7.810667
PYK_nh4_ko5.159721
PYRt2_nh4_ko17.017435
RPE_nh4_ko0.906345
RPI_nh4_ko-0.892617
TALA_nh4_ko0.526739
TKT1_nh4_ko0.526739
TKT2_nh4_ko0.379606
TPI_nh4_ko8.994934
EX_glc__D_e_nh4_ko-10.000000
EX_glu__L_e_nh4_ko-2.222409
EX_h2o_e_nh4_ko0.303946
EX_h_e_nh4_ko21.381758
EX_lac__D_e_nh4_ko20.076753
EX_o2_e_nh4_ko-5.315818
EX_pi_e_nh4_ko-1.499335
EX_pyr_e_nh4_ko-17.017435
EX_ac_e_nh4_ko7.810667
EX_akg_e_nh4_ko3.390348
EX_co2_e_nh4_ko12.016587
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "ACKr_nh4_ko -7.810667\n", + "ACONTa_nh4_ko 1.607668\n", + "ACONTb_nh4_ko 1.607668\n", + "ACt2r_nh4_ko -7.810667\n", + "AKGt2r_nh4_ko -3.390348\n", + "ATPM_nh4_ko 8.390000\n", + "ATPS4r_nh4_ko 10.578752\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", + "CO2t_nh4_ko -12.016587\n", + "CS_nh4_ko 1.607668\n", + "CYTBD_nh4_ko 10.631636\n", + "D_LACt2_nh4_ko -20.076753\n", + "ENO_nh4_ko 17.707169\n", + "FBA_nh4_ko 8.994934\n", + "G6PDH2r_nh4_ko 1.798962\n", + "GAPD_nh4_ko 18.316897\n", + "GLCpts_nh4_ko 10.000000\n", + "GLNS_nh4_ko 0.104216\n", + "GLUDy_nh4_ko 0.104216\n", + "GLUt2r_nh4_ko 2.222409\n", + "GND_nh4_ko 1.798962\n", + "H2Ot_nh4_ko -0.303946\n", + "ICDHyr_nh4_ko 1.607668\n", + "LDH_D_nh4_ko -20.076753\n", + "NADH16_nh4_ko 10.631636\n", + "O2t_nh4_ko 5.315818\n", + "PDH_nh4_ko 10.945833\n", + "PFK_nh4_ko 8.994934\n", + "PGI_nh4_ko 8.117486\n", + "PGK_nh4_ko -18.316897\n", + "PGL_nh4_ko 1.798962\n", + "PGM_nh4_ko -17.707169\n", + "PIt2r_nh4_ko 1.499335\n", + "PPC_nh4_ko 2.335877\n", + "PTAr_nh4_ko 7.810667\n", + "PYK_nh4_ko 5.159721\n", + "PYRt2_nh4_ko 17.017435\n", + "RPE_nh4_ko 0.906345\n", + "RPI_nh4_ko -0.892617\n", + "TALA_nh4_ko 0.526739\n", + "TKT1_nh4_ko 0.526739\n", + "TKT2_nh4_ko 0.379606\n", + "TPI_nh4_ko 8.994934\n", + "EX_glc__D_e_nh4_ko -10.000000\n", + "EX_glu__L_e_nh4_ko -2.222409\n", + "EX_h2o_e_nh4_ko 0.303946\n", + "EX_h_e_nh4_ko 21.381758\n", + "EX_lac__D_e_nh4_ko 20.076753\n", + "EX_o2_e_nh4_ko -5.315818\n", + "EX_pi_e_nh4_ko -1.499335\n", + "EX_pyr_e_nh4_ko -17.017435\n", + "EX_ac_e_nh4_ko 7.810667\n", + "EX_akg_e_nh4_ko 3.390348\n", + "EX_co2_e_nh4_ko 12.016587" + ] + }, + "execution_count": 18, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution.find('nh4_ko')" ] @@ -414,7 +1558,7 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 19, "id": "c4727cf5", "metadata": {}, "outputs": [], @@ -424,10 +1568,76 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 20, "id": "c80e5339", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n" + ] + }, + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
community_growth0.407572
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", + "community_growth 0.407572" + ] + }, + "execution_count": 20, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution = regComFBA(community,constraints=M9,obj_frac=1)\n", "solution.find('BIOMASS|growth', sort=True, show_nulls=True)" @@ -443,10 +1653,76 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 21, "id": "e6698a36", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n" + ] + }, + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
community_growth0.407572
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" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", + "community_growth 0.407572" + ] + }, + "execution_count": 21, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution=sim.simulate(method=regComFBA,constraints=M9,obj_frac=1)\n", "solution.find('BIOMASS|growth', sort=True, show_nulls=True)" @@ -472,10 +1748,33 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 22, "id": "2214667c", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.47it/s]" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n" + ] + }, + { + "name": "stderr", + "output_type": "stream", + "text": [ + "\n" + ] + } + ], "source": [ "solution = SteadyCom(community, constraints=M9)" ] @@ -490,10 +1789,23 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 23, "id": "50794ba1", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "Community growth: 0.027466848121545602\n", + "glc_ko\t1.0\n", + "nh4_ko\t30.78547721007576" + ] + }, + "execution_count": 23, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution" ] @@ -508,10 +1820,123 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 24, "id": "e5b8887e", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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donorreceivercompoundrate
14glc_konh4_koacald_e31.460909
13nh4_koglc_koac_e21.026083
4nh4_koglc_koh_e20.838688
18nh4_koglc_koetoh_e15.584869
6nh4_koglc_kolac__D_e5.896268
12glc_konh4_kopyr_e5.690096
15nh4_koglc_koakg_e4.689488
1glc_konh4_koglu__L_e4.610779
2glc_konh4_koh2o_e2.254232
\n", + "
" + ], + "text/plain": [ + " donor receiver compound rate\n", + "14 glc_ko nh4_ko acald_e 31.460909\n", + "13 nh4_ko glc_ko ac_e 21.026083\n", + "4 nh4_ko glc_ko h_e 20.838688\n", + "18 nh4_ko glc_ko etoh_e 15.584869\n", + "6 nh4_ko glc_ko lac__D_e 5.896268\n", + "12 glc_ko nh4_ko pyr_e 5.690096\n", + "15 nh4_ko glc_ko akg_e 4.689488\n", + "1 glc_ko nh4_ko glu__L_e 4.610779\n", + "2 glc_ko nh4_ko h2o_e 2.254232" + ] + }, + "execution_count": 24, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution.cross_feeding(as_df=True).dropna().sort_values('rate', ascending=False)" ] @@ -526,12 +1951,34 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 25, "id": "26e96715", "metadata": { "scrolled": true }, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Downloading Map from https://escher.github.io/1-0-0/6/maps/Escherichia%20coli/e_coli_core.Core%20metabolism.json\n" + ] + }, + { + "data": { + "application/vnd.jupyter.widget-view+json": { + "model_id": "a91a00f2cf364dbd8bf2d34891fc4672", + "version_major": 2, + "version_minor": 0 + }, + "text/plain": [ + "Builder(reaction_data={'ACALD': -15.876039737077187, 'ACALDt': -31.460908810361047, 'ACKr': 21.026083388520718…" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], "source": [ "from mewpy.visualization.escher import build_escher\n", "if 'google.colab' in str(get_ipython()):\n", @@ -543,10 +1990,32 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 26, "id": "3fe40d10", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Downloading Map from https://escher.github.io/1-0-0/6/maps/Escherichia%20coli/e_coli_core.Core%20metabolism.json\n" + ] + }, + { + "data": { + "application/vnd.jupyter.widget-view+json": { + "model_id": "e95a0848c5c244fba725f566d55e88bf", + "version_major": 2, + "version_minor": 0 + }, + "text/plain": [ + "Builder(reaction_data={'ACALD': 15.876039737077235, 'ACALDt': 31.460908810361047, 'ACKr': -21.026083388520718,…" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], "source": [ "build_escher(fluxes=solution.internal['nh4_ko'])" ] @@ -567,10 +2036,22 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 27, "id": "71695f63", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n", + "Strain\tMin\tMax\n", + "glc_ko\t0.0%\t99.9%\n", + "nh4_ko\t0.1%\t100.0%\n" + ] + } + ], "source": [ "from mewpy.com import SteadyComVA\n", "variability = SteadyComVA(community, obj_frac=0.9, constraints=M9)\n", @@ -600,7 +2081,7 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 28, "id": "34220805", "metadata": {}, "outputs": [], @@ -618,10 +2099,23 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 29, "id": "1c660055", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "objective: 0.40757209363986224\n", + "Status: OPTIMAL\n", + "Method:FBA" + ] + }, + "execution_count": 29, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "constraints={community.organisms_biomass['nh4_ko']:(0.1,1000), \n", " community.organisms_biomass['glc_ko']:(0.1,1000)}\n", @@ -631,10 +2125,63 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 30, "id": "ecb0bce0", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" + ] + }, + "execution_count": 30, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution.find('BIOMASS')" ] @@ -649,10 +2196,23 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 31, "id": "7ecc37ca", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqz1ce3qk.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwm8gh3y5.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n" + ] + } + ], "source": [ "community = CommunityModel([glc_ko, nh4_ko],\n", " add_compartments=True,\n", @@ -662,10 +2222,18 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 32, "id": "77f8eed9", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.36it/s]\n" + ] + } + ], "source": [ "sim = community.get_community_model()\n", "sim.set_environmental_conditions(M9)" @@ -673,10 +2241,72 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 33, "id": "7d604601", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "objective: 0.40757209363986224\n", + "Status: OPTIMAL\n", + "Method:FBA\n" + ] + }, + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.407572
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.407572
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" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" + ] + }, + "execution_count": 33, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution = sim.simulate()\n", "print(solution)\n", @@ -685,10 +2315,77 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 34, "id": "6402d86c", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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namelbubstoichiometrygprannotations
id
community_growthCommunity growth rate0inf{'Biomass_glc_ko': -1, 'Biomass_nh4_ko': -1}{}
\n", + "
" + ], + "text/plain": [ + " name lb ub \\\n", + "id \n", + "community_growth Community growth rate 0 inf \n", + "\n", + " stoichiometry gpr annotations \n", + "id \n", + "community_growth {'Biomass_glc_ko': -1, 'Biomass_nh4_ko': -1} {} " + ] + }, + "execution_count": 34, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "sim.find(community.biomass)" ] @@ -703,10 +2400,68 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 35, "id": "575721c6", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.105388
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.263471
community_growth0.105388
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.105388\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.263471\n", + "community_growth 0.105388" + ] + }, + "execution_count": 35, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "community.set_abundance({'glc_ko':1,'nh4_ko':2.5})\n", "sim.simulate(method='pFBA').find('BIOMASS|growth')" @@ -732,10 +2487,78 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 36, "id": "45d28b6e", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.37it/s]\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n" + ] + }, + { + "data": { + "text/html": [ + "
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Value
Attribute
glc_ko{'nh4_ko': 1.0}
nh4_ko{'glc_ko': 1.0}
\n", + "
" + ], + "text/plain": [ + " Value\n", + "Attribute \n", + "glc_ko {'nh4_ko': 1.0}\n", + "nh4_ko {'glc_ko': 1.0}" + ] + }, + "execution_count": 36, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "sc_score(community)" ] @@ -750,10 +2573,89 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 37, "id": "f779b482", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk29vpt4n.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzwfubp6w.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphldkumdm.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8gie1ue3.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpreyygnbm.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0b709klz.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n" + ] + }, + { + "data": { + "text/html": [ + "
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Value
Attribute
glc_ko{'ac_e': 0.06, 'acald_e': 0.28, 'akg_e': 0.2, ...
nh4_ko{'ac_e': 0.0, 'acald_e': 0.0, 'akg_e': 0.0, 'c...
\n", + "
" + ], + "text/plain": [ + " Value\n", + "Attribute \n", + "glc_ko {'ac_e': 0.06, 'acald_e': 0.28, 'akg_e': 0.2, ...\n", + "nh4_ko {'ac_e': 0.0, 'acald_e': 0.0, 'akg_e': 0.0, 'c..." + ] + }, + "execution_count": 37, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "MUS = mu_score(community)\n", "MUS" @@ -761,20 +2663,80 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 38, "id": "d6175f02", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "{'ac_e': 0.06,\n", + " 'acald_e': 0.28,\n", + " 'akg_e': 0.2,\n", + " 'co2_e': 0.0,\n", + " 'etoh_e': 0.17,\n", + " 'for_e': 0.0,\n", + " 'fru_e': 0.0,\n", + " 'fum_e': 0.0,\n", + " 'glc__D_e': 0.0,\n", + " 'gln__L_e': 0.0,\n", + " 'glu__L_e': 0.0,\n", + " 'h_e': 0.05,\n", + " 'h2o_e': 0.09,\n", + " 'lac__D_e': 0.24,\n", + " 'mal__L_e': 0.0,\n", + " 'nh4_e': 1.0,\n", + " 'o2_e': 0.94,\n", + " 'pi_e': 1.0,\n", + " 'pyr_e': 0.3,\n", + " 'succ_e': 0.08}" + ] + }, + "execution_count": 38, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "MUS.glc_ko" ] }, { "cell_type": "code", - "execution_count": null, + "execution_count": 39, "id": "9449a68c", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "{'ac_e': 0.0,\n", + " 'acald_e': 0.0,\n", + " 'akg_e': 0.0,\n", + " 'co2_e': 0.0,\n", + " 'etoh_e': 0.0,\n", + " 'for_e': 0.0,\n", + " 'fru_e': 0.0,\n", + " 'fum_e': 0.0,\n", + " 'glc__D_e': 1.0,\n", + " 'gln__L_e': 0.0,\n", + " 'glu__L_e': 1.0,\n", + " 'h_e': 0.0,\n", + " 'h2o_e': 0.0,\n", + " 'lac__D_e': 0.0,\n", + " 'mal__L_e': 0.0,\n", + " 'nh4_e': 0.0,\n", + " 'o2_e': 0.0,\n", + " 'pi_e': 1.0,\n", + " 'pyr_e': 0.0,\n", + " 'succ_e': 0.0}" + ] + }, + "execution_count": 39, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "MUS.nh4_ko" ] @@ -789,10 +2751,89 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 40, "id": "095e8c80", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpocp3cfxi.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp92qw9y9b.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpigwu83g3.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppbp1791u.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpanlc_ioh.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphrvcqeth.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n" + ] + }, + { + "data": { + "text/html": [ + "
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Value
Attribute
glc_ko{'etoh_e': 1, 'for_e': 1, 'h2o_e': 1, 'pyr_e':...
nh4_ko{'etoh_e': 1, 'for_e': 1, 'h2o_e': 1, 'pyr_e':...
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" + ], + "text/plain": [ + " Value\n", + "Attribute \n", + "glc_ko {'etoh_e': 1, 'for_e': 1, 'h2o_e': 1, 'pyr_e':...\n", + "nh4_ko {'etoh_e': 1, 'for_e': 1, 'h2o_e': 1, 'pyr_e':..." + ] + }, + "execution_count": 40, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "MPS = mp_score(community,environment=M9)\n", "MPS" @@ -808,10 +2849,139 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 41, "id": "761408d5", "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4dvynhd_.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdln1d9yn.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqvad029b.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqoc_b7uw.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8g_f0mu0.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl4kjrjo3.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpodxpo4re.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6_m2cck2.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcivs_dk8.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2fgz5fts.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfh7s1z14.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy8l4qeo9.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr3jxc3_d.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyunwlm_i.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpijaen0n7.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaa3pm_v5.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj7iciq21.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4xetwaml.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9byblcdr.lp\n", + "Reading time = 0.00 seconds\n", + ": 166 rows, 426 columns, 1572 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfn5t3nza.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpashf3mvp.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Set parameter FeasibilityTol to value 1e-09\n", + "Set parameter OptimalityTol to value 1e-09\n", + "0.2857142857142857\n" + ] + }, + { + "data": { + "text/html": [ + "
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Value
Attribute
community_medium{gln, pi, glc}
individual_media{'glc_ko': {'o2', 'akg', 'nh4', 'pi'}, 'nh4_ko...
\n", + "
" + ], + "text/plain": [ + " Value\n", + "Attribute \n", + "community_medium {gln, pi, glc}\n", + "individual_media {'glc_ko': {'o2', 'akg', 'nh4', 'pi'}, 'nh4_ko..." + ] + }, + "execution_count": 41, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "score, MRO = mro_score(community,environment=M9)\n", "print(score)\n", @@ -820,20 +2990,42 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 42, "id": "2f72f3c5", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "{'akg', 'nh4', 'o2', 'pi'}" + ] + }, + "execution_count": 42, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "MRO.individual_media.glc_ko" ] }, { "cell_type": "code", - "execution_count": null, + "execution_count": 43, "id": "d5461666", "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "{'glc', 'glu', 'pi'}" + ] + }, + "execution_count": 43, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "MRO.individual_media.nh4_ko" ] diff --git a/examples/09-crossfeeding.ipynb b/examples/09-crossfeeding.ipynb index dfad5f2b..490f7038 100644 --- a/examples/09-crossfeeding.ipynb +++ b/examples/09-crossfeeding.ipynb @@ -147,10 +147,10 @@ "name": "stdout", "output_type": "stream", "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj2gqys7h.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp52jr2h38.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpau1cix46.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7_8udlxf.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n" ] @@ -179,6 +179,15 @@ "scrolled": true }, "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpno2v1xi0.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n" + ] + }, { "data": { "text/html": [ @@ -405,7 +414,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "100%|███████████████████████████████████████| 137/137 [00:00<00:00, 2767.45it/s]" + "100%|███████████████████████████████████████| 137/137 [00:00<00:00, 2722.75it/s]" ] }, { @@ -426,470 +435,790 @@ "name": "stdout", "output_type": "stream", "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbbw_09mz.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0lq4wf_a.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw6bbk62k.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3jnvqy_p.lp\n", + "Reading time = 0.01 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6c9ebryt.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5c3wmxym.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphwixz8t3.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxnosy9vc.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkqxkxz3a.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfez5wsxk.lp\n", + "Reading time = 0.01 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwoz22a25.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyi629nd4.lp\n", + "Reading time = 0.00 seconds\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9q4lggki.lp\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_menbojx.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdad_tt1n.lp\n", "Reading time = 0.00 seconds\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8yusets3.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpep63916e.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjvha3o4a.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw3f2ts06.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq9mluepc.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxkyh018x.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe5ygabpr.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6_600jap.lp\n", + "Reading time = 0.01 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2hh42y9h.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_p7cpy6q.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbotsgc1e.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5_28u09v.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg3il1llb.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptl2iut7t.lp\n", "Reading time = 0.00 seconds\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa_1yxmf3.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl256e4l_.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjuw6110b.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9nxl0xab.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpogbs7vsx.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpchwaep9p.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx1prx3_l.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9wnln8qq.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr9wx53ll.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpurvvfrbf.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzaaqni25.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy6j1vytv.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2j_9b6wc.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpghlrvql6.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfxvqy3_8.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprgull_gf.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", "Eval(s)| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev|\n", - " 100| 0.000000 0.873922 0.125160 0.188822 0.260158| 1.000000 30.000000 13.500000 15.140000 8.580233|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9otg7h2i.lp\n", + " 100| 0.000000 0.873922 0.065209 0.222020 0.300277| 1.000000 30.000000 16.000000 15.620000 9.447518|\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmb53smhz.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_my65gk9.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv0tzc9ca.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0hz5ce7r.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1i_jzx08.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplwn7_5vt.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu84phupy.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6fohgt5n.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnjws9rxt.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcjk_4meg.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0kuwtm5m.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1zfe8vzs.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxnl6jt42.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8e14j9rr.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyvhrdxdd.lp\n", + "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.01 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp87_pyrs1.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpser1i5dt.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1k6otqic.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp47yj14t_.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp52sq9vdv.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0pmc5ths.lp\n", "Reading time = 0.00 seconds\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg_1b4gsz.lp\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpat3acpyu.lp\n", "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2isubu_r.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp913ykznz.lp\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfrxqs9ll.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgrwm_g4r.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu1mr_xvc.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpebb76h1d.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq6p363uj.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - " 200| 0.000000 0.873922 0.196462 0.270393 0.295199| 2.000000 30.000000 18.000000 17.750000 8.434898|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmdvfrx2b.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyzlycrky.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphk0262z7.lp\n", - "Reading time = 0.01 seconds\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpudr4h687.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9b9ie7p3.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa0lbhuvk.lp\n", + "Reading time = 0.00 seconds\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + ": 72 rows, 190 columns, 720 nonzeros\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeet6t4jj.lp\n", + "Reading time = 0.00 seconds\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm5387uaj.lp\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprc8qme3y.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5anqx6n3.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpivblmpb8.lp\n", + "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkfdylo2w.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw9qkp56_.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfjkln7ch.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp39qlugi8.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy9tau5s8.lp\n", + "Reading time = 0.00 seconds\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0zeqt_yp.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi05d373n.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + " 200| 0.000000 0.873922 0.196462 0.333796 0.346888| 1.000000 30.000000 19.000000 17.120000 10.100772|\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjdpoifp6.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyuc5ipul.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp97pgru4u.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph6d68t_v.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5zl3uz8u.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxoghllxe.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0li54sqc.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmposoosb7f.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1k2mwdx2.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgn8i9aih.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuwkf9v0_.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj0dla6o7.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzti94_9v.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_i9oy02a.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpid6bakix.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpswg2c_ox.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpboyvk5ji.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3ka5no3e.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxhxom9kk.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoohmlfva.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpynzdgfla.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzjl6dy5u.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpipktagkg.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxvhag9nh.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg9yy9a76.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1rdatc7c.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6kpy196y.lp\n", + "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt3k6zv3t.lp\n", "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8n_oa_65.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8_gc_hiq.lp\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3cfbpv2e.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpev1xpa42.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprjoslfe3.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpumvexz72.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9qfq1pib.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmc10_2r_.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9mrkhlj6.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpobr5fvk4.lp\n", + " 300| 0.000000 0.873922 0.068455 0.295471 0.363284| 1.000000 30.000000 26.000000 20.520000 10.059304|\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpza2nlwxx.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpes015qlg.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprkukgcy3.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpucxn5tgz.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmped_61ltm.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph36ti9uj.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsmcs0_33.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - " 300| 0.000000 0.873922 0.198302 0.326997 0.348299| 3.000000 30.000000 21.000000 20.140000 8.988904|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7dke2eey.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpegnr89u_.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps6c_m90o.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzbghnwfx.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqa4wdz_6.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmlxu5334.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv4xjatjm.lp\n" + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk1cl2ly5.lp\n", + "Reading time = 0.02 seconds\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz0q_oc6a.lp\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Reading time = 0.03 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprds5jug3.lp\n", + ": 72 rows, 190 columns, 720 nonzeros\n" ] }, { "name": "stdout", "output_type": "stream", "text": [ + "Reading time = 0.00 seconds\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwpt5jodw.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvygrn10p.lp\n", + "Reading time = 0.01 seconds\n", + "Reading time = 0.01 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplkyq2f1u.lp\n", + "Reading time = 0.02 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv93bknet.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppyz82g64.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppr5nszze.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7dvvgxgf.lp\n", + "Reading time = 0.00 seconds\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpowlsj5o8.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpak_461e7.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaau41pxw.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1_za0nco.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_y30k93r.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7shk6j7d.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp09xbvmr7.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmjn16fhb.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg4pk666o.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjc3r0bcu.lp\n", + "Reading time = 0.00 seconds\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiir2mdy5.lp\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfn5cs1z9.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_rx_phoq.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + " 400| 0.000000 0.873922 0.000000 0.171581 0.314601| 2.000000 30.000000 29.000000 25.490000 7.986858|\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkir13m7i.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppmpgp2g3.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfjjui_7l.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeb4o2duh.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyniowia_.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq7vb6lii.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph18hdoyi.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuljhjwo6.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb_g77wbj.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd8he94_0.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfe513gkw.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmvimn6le.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcma4i9n9.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxj4a6czt.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa7na5kv8.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp05om_dgl.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4c293vhx.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpha447385.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe7hzmj35.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Reading time = 0.00 seconds\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_qu7qy7p.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3itrlqkd.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyo3apifv.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptg_po8b3.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmlr94gue.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9iz657kd.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsifv8bxq.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1kt9r0n9.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmz8h_pm9.lp\n", + "Reading time = 0.00 seconds\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmpi27o72.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyrzfoni9.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa0ryu6vq.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppobh7638.lp\n", + " 500| 0.000000 0.873922 0.000000 0.170146 0.314288| 2.000000 30.000000 30.000000 26.180000 8.162573|\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwp107rlb.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxe6dnmr5.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjypu2ygi.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphaeeac_j.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnhy9stqv.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppil5vwwd.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpncxkg0nv.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_uveeega.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb5cmplhy.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw5jmp5ox.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1zgqph3f.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplqbyz0_o.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz4z94wa4.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptzsxu38b.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpskqopetm.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6pjgkce6.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf1nwsx_2.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3_c347te.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa_tywrza.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - " 400| 0.000000 0.873922 0.080484 0.292032 0.349099| 3.000000 30.000000 28.500000 23.020000 8.469923|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2w9ty1di.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps0yt72wl.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppdh5wt36.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu1npndmy.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjfxzm9i6.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgfqjcl2_.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzelwiyjl.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprndh0plk.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv1ge1okx.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjz7xo9rv.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn25975gf.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz6_ggbse.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxcp75ogm.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphsag4lz4.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv1lf_bkx.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5pimgs6v.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph3zs65it.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnq71wv62.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvlzb_7cm.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbrejwxjv.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsyn7w1nv.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnfkgiexd.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqma2qmyf.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpafldcdrt.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1gy5a2a5.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaxoi7jj3.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv_vjykqs.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn1gb3lqe.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv0ye0i7b.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfbmsw7c0.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - " 500| 0.000000 0.873922 0.141937 0.303455 0.350307| 6.000000 30.000000 30.000000 23.700000 8.033057|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppm0svz7c.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfidox7sq.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx19w69_3.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjm2y55nl.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpto09a_2h.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptc82j46y.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo81ucf0e.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp63u2akm9.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppqm9_2sy.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwq63ehyv.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg7e4rg3r.lp\n", + " 600| 0.000000 0.873922 0.192520 0.340928 0.361032| 2.000000 30.000000 29.000000 22.230000 9.627933|\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnzilsju1.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkg6go3zc.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeb898kf0.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyios6ufv.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9qbg72d6.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt_14re3j.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprhw5via3.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjl7p46gy.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxdd2dtkb.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf20l7b22.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprusolbyv.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcflnh0q_.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp74i1abqq.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp40e5eaph.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv10ytzs0.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp21asxcty.lp\n", + "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa6d9ztld.lp\n", "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpseazksa3.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1xszk7nm.lp\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp47qjuar.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - " 600| 0.000000 0.873922 0.000000 0.290206 0.355122| 6.000000 30.000000 30.000000 24.750000 7.292976|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9_8i3546.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwm2wqko3.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpigu86ped.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp212v7pdd.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbiwxbi1m.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph4d6exwd.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuzip2nrm.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprmplhv7v.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4dmojmsx.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe6bvqo_f.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptm1fzl4x.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7nu5re5c.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp712c0gi2.lp\n", + "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8wel7v5i.lp\n", "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpour77xt1.lp\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkja5bp47.lp\n", "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnlizio53.lp\n" + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp513odgmg.lp\n" ] }, { "name": "stdout", "output_type": "stream", "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfo5tx0dq.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5ujn2sqq.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiqn3sd3a.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmdkdcjhv.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp94id5y8t.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq6qfr2bh.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4ekfnsaq.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgupk217j.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt3zvwtz7.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvwnwgfa5.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuxse_ewe.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpytwc13ns.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjvly43y3.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - " 700| 0.000000 0.873922 0.000000 0.250983 0.347516| 9.000000 30.000000 30.000000 25.890000 6.532832|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwy9o69xi.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp91096trp.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppjupttxz.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwrv0u88e.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoenra4kp.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm1knfo72.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpviqd951q.lp\n", + " 700| 0.000000 0.873922 0.617037 0.546602 0.291302| 2.000000 30.000000 20.000000 18.570000 9.060083|\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7_h0tahd.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprca0_77d.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxp6oh8pf.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo9x83o4e.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7pjeg15j.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9tfzy02j.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9xvkau88.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3higwhcp.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_gwmxnpl.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprkxywptb.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp746t3j9n.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8i0uq2fz.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqnb2m68c.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdd9n82gc.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbfuq53as.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi_xj4x0s.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmba8o0ov.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpux82qsr9.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq7r0yamn.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8mnd7hup.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpygmclbcb.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1ktoi2nl.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfokjywfe.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - " 800| 0.000000 0.873922 0.000000 0.282855 0.356941| 10.000000 30.000000 30.000000 25.590000 6.534669|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0u706gfi.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2jz4wczo.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp66k397kt.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw941q777.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppwuep4gz.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptosncwke.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp562o0yk6.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphfgpyq73.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgw459i18.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6hd130s_.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjy09tjw3.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1ofzz64y.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvoze_q4p.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_rhe8r67.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyzmvmswt.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxoz96z6z.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw7m9ysvm.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpntve1rns.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp11ybfr0l.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6hl4wzee.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzt_fufk7.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzx6_muff.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk1ui_k1z.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprhlwpcu8.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptgkb00d3.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpln7p_0y2.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpupsw4etu.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkajav0qp.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpezvv4xn4.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy6stp1pu.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - " 900| 0.000000 0.873922 0.232589 0.354791 0.349950| 10.000000 30.000000 29.000000 25.110000 6.123553|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp347991ot.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6x18aa4s.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp375cipga.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzeyw81e3.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaa29y6zn.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1ki0pxi_.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", + " 800| 0.167609 0.873922 0.617037 0.590059 0.259511| 3.000000 30.000000 20.000000 19.790000 7.741182|\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvfuhe7zb.lp\n", + "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfn1u0ugv.lp\n", "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvmnq97rb.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp71u5j8l1.lp\n", + ": 72 rows, 190 columns, 720 nonzeros\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmepalkb8.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzu8qr315.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphkpgab9l.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2itbx1dx.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfolea5qg.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcbne488d.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp41adxrs2.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpookcqijg.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5s0n4uiw.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp52mxdbo2.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnju1r77k.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp87s166_a.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd_d2zud8.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5alanek8.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6l9k9oh0.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpguhdszp1.lp\n" + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd7iyhct_.lp\n" ] }, { @@ -898,42 +1227,193 @@ "text": [ "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdyv8l1_m.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgnmmji4e.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp35tofa00.lp\n", + "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaa0y4uo_.lp\n", "Reading time = 0.00 seconds\n", ": 72 rows, 190 columns, 720 nonzeros\n", - " 1000| 0.192520 0.873922 0.374230 0.529385 0.281540| 10.000000 30.000000 23.000000 22.980000 5.861706|\n" - ] - } - ], - "source": [ - "from mewpy.optimization import EA\n", - "ea = EA(problem, max_generations=10)\n", - "gkos = ea.run(simplify=False)" - ] - }, - { - "cell_type": "markdown", - "id": "49b54036", - "metadata": {}, - "source": [ - "We can have a look to the solution found by the evolutionary algoritm (EA)" - ] - }, - { - "cell_type": "code", - "execution_count": 11, - "id": "22b63cf1", - "metadata": {}, - "outputs": [ - { - "data": { - "text/html": [ - "
\n", - "\n", + "\n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + "
Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_ec10.415598
BIOMASS_Ecoli_core_w_GAM_ec20.415598
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_ec1 0.415598\n", + "BIOMASS_Ecoli_core_w_GAM_ec2 0.415598" + ] + }, + "execution_count": 30, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "problem.simulate(solution=solution.values,method='pFBA').find('BIOMASS',show_nulls=True)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "d8bd1cc7", + "metadata": {}, "outputs": [], "source": [] } From f8e2dd96e32c6cb1b091aa819a6ebc0debaea617 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 29 Jun 2024 00:15:56 +0100 Subject: [PATCH 07/24] Update notebooks --- examples/01-simulation.ipynb | 318 +- examples/02-optimization.ipynb | 3497 +++------ examples/04-ROUproblem.ipynb | 8 +- examples/05-GOUproblem.ipynb | 4 +- examples/06-GeckoKOProblem.ipynb | 8 +- examples/08-community.ipynb | 1124 +-- examples/09-crossfeeding.ipynb | 11762 ++--------------------------- 7 files changed, 2106 insertions(+), 14615 deletions(-) diff --git a/examples/01-simulation.ipynb b/examples/01-simulation.ipynb index 5c1e9f0e..1227d302 100644 --- a/examples/01-simulation.ipynb +++ b/examples/01-simulation.ipynb @@ -27,17 +27,17 @@ "name": "stdout", "output_type": "stream", "text": [ - "MEWpy version: 0.1.23\n", - "Author: BiSBII CEB University of Minho\n", + "MEWpy version: 0.1.35\n", + "Author: Vitor Pereira and CEB University of Minho (2019-2023)\n", "Contact: vpereira@ceb.uminho.pt \n", "\n", - "Available LP solvers: cplex glpk\n", + "Available LP solvers: gurobi cplex glpk\n", "Default LP solver: cplex \n", "\n", - "Available ODE solvers: scipy odespy\n", - "Default ODE solver: scipy \n", + "Available ODE solvers: scikits scipy\n", + "Default ODE solver: scikits \n", "\n", - "Optimization Problems: AbstractKOProblem AbstractOUProblem CommunityKOProblem ETFLGKOProblem ETFLGOUProblem GKOProblem GOUProblem GeckoKOProblem GeckoOUProblem KcatOptProblem KineticKOProblem KineticOUProblem MediumProblem OptORFProblem OptRamProblem RKOProblem ROUProblem \n", + "Optimization Problems: AbstractKOProblem AbstractOUProblem CofactorSwapProblem CommunityKOProblem ETFLGKOProblem ETFLGOUProblem GKOProblem GOUProblem GeckoKOProblem GeckoOUProblem KcatOptProblem KineticKOProblem KineticOUProblem MediumProblem OptORFProblem OptRamProblem RKOProblem ROUProblem \n", "\n", "Available EA engines: inspyred jmetal\n", "Default EA engine: jmetal\n", @@ -72,7 +72,16 @@ "cell_type": "code", "execution_count": 3, "metadata": {}, - "outputs": [], + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Set parameter Username\n", + "Academic license - for non-commercial use only - expires 2024-12-11\n" + ] + } + ], "source": [ "from cobra.io import read_sbml_model\n", "model = read_sbml_model('models/ec/e_coli_core.xml.gz')" @@ -1261,7 +1270,6 @@ "text/plain": [ "objective: 0.21166294973531058\n", "Status: OPTIMAL\n", - "Constraints: OrderedDict([('EX_glc__D_e', (-10.0, 100000.0)), ('EX_o2_e', (0, 0))])\n", "Method:FBA" ] }, @@ -1300,9 +1308,8 @@ { "data": { "text/plain": [ - "objective: 335.65061686292484\n", + "objective: 335.650616862925\n", "Status: OPTIMAL\n", - "Constraints: OrderedDict([('EX_glc__D_e', (-10.0, 100000.0)), ('EX_o2_e', (0, 0))])\n", "Method:pFBA" ] }, @@ -1334,55 +1341,55 @@ { "data": { "text/plain": [ - "OrderedDict([('ACALD', -8.279455380486564),\n", + "OrderedDict([('ACALD', -8.279455380486585),\n", " ('ACALDt', 0.0),\n", - " ('ACKr', -8.50358527796132),\n", + " ('ACKr', -8.503585277961339),\n", " ('ACONTa', 0.22836315646942662),\n", " ('ACONTb', 0.22836315646942662),\n", - " ('ACt2r', -8.50358527796132),\n", + " ('ACt2r', -8.503585277961339),\n", " ('ADK1', 0.0),\n", " ('AKGDH', 0.0),\n", " ('AKGt2r', 0.0),\n", - " ('ALCD2x', -8.279455380486564),\n", + " ('ALCD2x', -8.279455380486585),\n", " ('ATPM', 8.39),\n", - " ('ATPS4r', -5.452052576810921),\n", + " ('ATPS4r', -5.452052576810891),\n", " ('BIOMASS_Ecoli_core_w_GAM', 0.21166294973531058),\n", " ('CO2t', 0.3781781922920794),\n", " ('CS', 0.22836315646942662),\n", " ('CYTBD', 0.0),\n", " ('D_LACt2', 0.0),\n", - " ('ENO', 19.1206886079146),\n", - " ('ETOHt2r', -8.279455380486564),\n", - " ('EX_ac_e', 8.50358527796132),\n", + " ('ENO', 19.12068860791461),\n", + " ('ETOHt2r', -8.279455380486585),\n", + " ('EX_ac_e', 8.503585277961339),\n", " ('EX_acald_e', 0.0),\n", " ('EX_akg_e', 0.0),\n", " ('EX_co2_e', -0.3781781922920794),\n", - " ('EX_etoh_e', 8.279455380486564),\n", - " ('EX_for_e', 17.804674217935307),\n", + " ('EX_etoh_e', 8.279455380486585),\n", + " ('EX_for_e', 17.804674217935315),\n", " ('EX_fru_e', 0.0),\n", " ('EX_fum_e', 0.0),\n", " ('EX_glc__D_e', -10.0),\n", " ('EX_gln__L_e', 0.0),\n", " ('EX_glu__L_e', 0.0),\n", - " ('EX_h_e', 30.554218267587004),\n", - " ('EX_h2o_e', -7.115795981726796),\n", + " ('EX_h_e', 30.55421826758694),\n", + " ('EX_h2o_e', -7.115795981726759),\n", " ('EX_lac__D_e', 0.0),\n", " ('EX_mal__L_e', 0.0),\n", " ('EX_nh4_e', -1.1541557323167015),\n", " ('EX_o2_e', 0.0),\n", - " ('EX_pi_e', -0.7786444931912726),\n", + " ('EX_pi_e', -0.7786444931913277),\n", " ('EX_pyr_e', 0.0),\n", " ('EX_succ_e', -0.0),\n", - " ('FBA', 9.789458863898286),\n", + " ('FBA', 9.789458863898297),\n", " ('FBP', 0.0),\n", " ('FORt2', 0.0),\n", - " ('FORt', -17.804674217935307),\n", + " ('FORt', -17.804674217935315),\n", " ('FRD7', 0.0),\n", " ('FRUpts2', 0.0),\n", " ('FUM', 0.0),\n", " ('FUMt2_2', 0.0),\n", " ('G6PDH2r', 0.0),\n", - " ('GAPD', 19.437336380718627),\n", + " ('GAPD', 19.437336380718634),\n", " ('GLCpts', 10.0),\n", " ('GLNS', 0.05412221624731891),\n", " ('GLNabc', 0.0),\n", @@ -1391,7 +1398,7 @@ " ('GLUSy', 0.0),\n", " ('GLUt2r', 0.0),\n", " ('GND', 0.0),\n", - " ('H2Ot', 7.115795981726796),\n", + " ('H2Ot', 7.115795981726759),\n", " ('ICDHyr', 0.22836315646942662),\n", " ('ICL', 0.0),\n", " ('LDH_D', 0.0),\n", @@ -1405,18 +1412,18 @@ " ('NH4t', 1.1541557323167015),\n", " ('O2t', 0.0),\n", " ('PDH', 0.0),\n", - " ('PFK', 9.789458863898286),\n", - " ('PFL', 17.804674217935307),\n", + " ('PFK', 9.789458863898297),\n", + " ('PFL', 17.804674217935315),\n", " ('PGI', 9.95660909530426),\n", - " ('PGK', -19.437336380718627),\n", + " ('PGK', -19.437336380718634),\n", " ('PGL', 0.0),\n", - " ('PGM', -19.1206886079146),\n", - " ('PIt2r', 0.7786444931912726),\n", + " ('PGM', -19.12068860791461),\n", + " ('PIt2r', 0.7786444931913277),\n", " ('PPC', 0.606541348761506),\n", " ('PPCK', 0.0),\n", " ('PPS', 0.0),\n", - " ('PTAr', 8.50358527796132),\n", - " ('PYK', 8.404273021945496),\n", + " ('PTAr', 8.503585277961339),\n", + " ('PYK', 8.404273021945503),\n", " ('PYRt2', 0.0),\n", " ('RPE', -0.15214332826974125),\n", " ('RPI', -0.15214332826974125),\n", @@ -1425,10 +1432,10 @@ " ('SUCDi', 0.0),\n", " ('SUCOAS', 0.0),\n", " ('TALA', -0.03786650170764707),\n", - " ('THD2', 3.629194102456646),\n", + " ('THD2', 3.629194102456609),\n", " ('TKT1', -0.03786650170764707),\n", " ('TKT2', -0.11427682656209417),\n", - " ('TPI', 9.789458863898286)])" + " ('TPI', 9.789458863898297)])" ] }, "execution_count": 18, @@ -1486,10 +1493,6 @@ " -8.279455\n", " \n", " \n", - " ACALDt\n", - " 0.000000\n", - " \n", - " \n", " ACKr\n", " -8.503585\n", " \n", @@ -1502,8 +1505,156 @@ " 0.228363\n", " \n", " \n", - " ...\n", - " ...\n", + " ACt2r\n", + " -8.503585\n", + " \n", + " \n", + " ALCD2x\n", + " -8.279455\n", + " \n", + " \n", + " ATPM\n", + " 8.390000\n", + " \n", + " \n", + " ATPS4r\n", + " -5.452053\n", + " \n", + " \n", + " BIOMASS_Ecoli_core_w_GAM\n", + " 0.211663\n", + " \n", + " \n", + " CO2t\n", + " 0.378178\n", + " \n", + " \n", + " CS\n", + " 0.228363\n", + " \n", + " \n", + " ENO\n", + " 19.120689\n", + " \n", + " \n", + " ETOHt2r\n", + " -8.279455\n", + " \n", + " \n", + " EX_ac_e\n", + " 8.503585\n", + " \n", + " \n", + " EX_co2_e\n", + " -0.378178\n", + " \n", + " \n", + " EX_etoh_e\n", + " 8.279455\n", + " \n", + " \n", + " EX_for_e\n", + " 17.804674\n", + " \n", + " \n", + " EX_glc__D_e\n", + " -10.000000\n", + " \n", + " \n", + " EX_h_e\n", + " 30.554218\n", + " \n", + " \n", + " EX_h2o_e\n", + " -7.115796\n", + " \n", + " \n", + " EX_nh4_e\n", + " -1.154156\n", + " \n", + " \n", + " EX_pi_e\n", + " -0.778644\n", + " \n", + " \n", + " FBA\n", + " 9.789459\n", + " \n", + " \n", + " FORt\n", + " -17.804674\n", + " \n", + " \n", + " GAPD\n", + " 19.437336\n", + " \n", + " \n", + " GLCpts\n", + " 10.000000\n", + " \n", + " \n", + " GLNS\n", + " 0.054122\n", + " \n", + " \n", + " GLUDy\n", + " -1.100034\n", + " \n", + " \n", + " H2Ot\n", + " 7.115796\n", + " \n", + " \n", + " ICDHyr\n", + " 0.228363\n", + " \n", + " \n", + " NH4t\n", + " 1.154156\n", + " \n", + " \n", + " PFK\n", + " 9.789459\n", + " \n", + " \n", + " PFL\n", + " 17.804674\n", + " \n", + " \n", + " PGI\n", + " 9.956609\n", + " \n", + " \n", + " PGK\n", + " -19.437336\n", + " \n", + " \n", + " PGM\n", + " -19.120689\n", + " \n", + " \n", + " PIt2r\n", + " 0.778644\n", + " \n", + " \n", + " PPC\n", + " 0.606541\n", + " \n", + " \n", + " PTAr\n", + " 8.503585\n", + " \n", + " \n", + " PYK\n", + " 8.404273\n", + " \n", + " \n", + " RPE\n", + " -0.152143\n", + " \n", + " \n", + " RPI\n", + " -0.152143\n", " \n", " \n", " TALA\n", @@ -1527,25 +1678,58 @@ " \n", " \n", "\n", - "

95 rows × 1 columns

\n", "" ], "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "ACALD -8.279455\n", - "ACALDt 0.000000\n", - "ACKr -8.503585\n", - "ACONTa 0.228363\n", - "ACONTb 0.228363\n", - "... ...\n", - "TALA -0.037867\n", - "THD2 3.629194\n", - "TKT1 -0.037867\n", - "TKT2 -0.114277\n", - "TPI 9.789459\n", - "\n", - "[95 rows x 1 columns]" + " Flux rate\n", + "Reaction ID \n", + "ACALD -8.279455\n", + "ACKr -8.503585\n", + "ACONTa 0.228363\n", + "ACONTb 0.228363\n", + "ACt2r -8.503585\n", + "ALCD2x -8.279455\n", + "ATPM 8.390000\n", + "ATPS4r -5.452053\n", + "BIOMASS_Ecoli_core_w_GAM 0.211663\n", + "CO2t 0.378178\n", + "CS 0.228363\n", + "ENO 19.120689\n", + "ETOHt2r -8.279455\n", + "EX_ac_e 8.503585\n", + "EX_co2_e -0.378178\n", + "EX_etoh_e 8.279455\n", + "EX_for_e 17.804674\n", + "EX_glc__D_e -10.000000\n", + "EX_h_e 30.554218\n", + "EX_h2o_e -7.115796\n", + "EX_nh4_e -1.154156\n", + "EX_pi_e -0.778644\n", + "FBA 9.789459\n", + "FORt -17.804674\n", + "GAPD 19.437336\n", + "GLCpts 10.000000\n", + "GLNS 0.054122\n", + "GLUDy -1.100034\n", + "H2Ot 7.115796\n", + "ICDHyr 0.228363\n", + "NH4t 1.154156\n", + "PFK 9.789459\n", + "PFL 17.804674\n", + "PGI 9.956609\n", + "PGK -19.437336\n", + "PGM -19.120689\n", + "PIt2r 0.778644\n", + "PPC 0.606541\n", + "PTAr 8.503585\n", + "PYK 8.404273\n", + "RPE -0.152143\n", + "RPI -0.152143\n", + "TALA -0.037867\n", + "THD2 3.629194\n", + "TKT1 -0.037867\n", + "TKT2 -0.114277\n", + "TPI 9.789459" ] }, "execution_count": 19, @@ -1572,7 +1756,7 @@ { "data": { "text/plain": [ - "9.789458863898286" + "9.789458863898297" ] }, "execution_count": 20, @@ -1661,7 +1845,7 @@ { "data": { "text/plain": [ - "'0.3781781922920794 co2_e + 10.0 glc__D_e + 7.115795981726796 h2o_e + 1.1541557323167015 nh4_e + 0.7786444931912726 pi_e --> 8.50358527796132 ac_e + 8.279455380486564 etoh_e + 17.804674217935307 for_e + 30.554218267587004 h_e'" + "'0.3781781922920794 co2_e + 10.0 glc__D_e + 7.115795981726759 h2o_e + 1.1541557323167015 nh4_e + 0.7786444931913277 pi_e --> 8.503585277961339 ac_e + 8.279455380486585 etoh_e + 17.804674217935315 for_e + 30.55421826758694 h_e'" ] }, "execution_count": 22, @@ -2091,14 +2275,12 @@ }, { "data": { - "image/png": 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\n", 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VFhbmoWoBXIggk4cgA0DK30ph/fr1ys7Oto1p3ry5rZVClSpVPFQtAIJMHoIMgIIU1Erhj/879PHxUYcOHdS3b1/FxMTQSgG4wggyeQgyAIrifCuF8xOHC2ql0KNHD+uOTadOnWilAJQigkweggyAkvj111+1bNkyq0dUQa0UoqKirGATGRnJxGHAjQgyeQgyAC6XMUYpKSlatmyZVqxYobVr1yo9Pd02platWraJww0bNvRMsUAZQZDJQ5AB4G45OTlKTk62WikkJibma6Vw9dVXW6Hm2muvpZUCUEwEmTwEGQCl7cyZM1q7dq0VbApqpdCmTRtbK4WQkBAPVQs4A0EmD0EGwJVWlFYKXbp0sbVSCAgI8FC1gHciyOQhyADwtMOHDys2NpZWCkAxEGTyEGQAeJvdu3dbE4dppQAUjCCThyADwJsZY/K1UsjIyLCNqVevnhVqaKWA8oIgk4cgA8BJzp49q8TERKuVQnJyMq0UUC4RZPIQZAA42flWCitWrNDKlSu1ZcuWQlsp9O3bV9dccw2tFFAmEGTyEGQAlCXHjh2ztVLYs2ePbX+FChVsrRQ6d+5MKwU4EkEmD0EGQFm2f/9+a0XU6tWrdejQIdv+kJAQWyuFVq1aMXEYjkCQyUOQAVBeGGO0Y8cOxcbGKi4uTmvWrMnXSqFmzZpWK4WYmBhaKcBrEWTyEGQAlFc5OTlav369tSKKVgpwEoJMHoIMAPzuj60UVq5cqY0bN9JKAV6LIJOHIAMABUtPT7e1UkhJSbHtp5UCPIkgk4cgAwBFc/jwYesbh1etWqVff/3Vtj8oKChfKwVfX18PVYuyjiCThyADACWzZ88eK9isXr06XyuFKlWq2FopNG3alBVRcBuCTB6CDABcPmOMNm/ebE0cXrduXb5WCnXr1rW1Uqhbt66HqkVZQJDJQ5ABAPfLzs62tVJISkrK10qhWbNmVqjp06cPrRRQLASZPAQZACh9mZmZWrVqlbUi6sJWCi6XK18rhauuusqDFcPbEWTyEGQA4MorSiuF7t2721op+Pv7e6haeCOCTB6CDAB4XlFaKfTu3dv6xmFaKYAgk4cgAwDe5cJWCmvXrlVaWpptzB9bKfTt21cREREeqhaeQpDJQ5ABAO+Wm5ubr5XC6dOnbWMiIiJsrRRq1qzpoWpxpRBk8hBkAMBZsrKy8rVSOHfunG1M69atba0U+P902UOQyUOQAQBnO3nypFasWGFNHN6+fbttv6+vr62VQvfu3WmlUAYQZPIQZACgbDly5Iht4vC+ffts+4OCgnTNNddYwaZ9+/a0UnAggkweggwAlG0///yzrZXC0aNHbfurVKmi6OhoK9g0a9aMFVEO4Iggs2zZMr322mtKSEjQwYMHNXfuXA0dOtTab4zRhAkT9MEHH+jEiRPq2bOnpk6dqiZNmhT5NQgyAFB+GGO0ZcsWWyuFU6dO2cbUrVvXtiKqXr16HqoWF1PU398+V7CmfDIyMtS2bVtNmTKlwP2vvvqq/vWvf2natGlas2aNgoOD1a9fP505c+YKVwoAcAKXy6XIyEg98MAD+uSTT7Rp0yZ99dVXeuyxx9SlSxdVqFBB+/fv18cff6yRI0cqPDxczZs315gxY/TVV1/la4wJ7+c1Hy25XC7bHRljjMLCwvT444/riSeekCSlpaWpVq1amjFjhu64444inZc7MgCA8/7YSmHVqlXasmWLcnNzrf20UvAeRf397XcFayqWPXv2KDU1VTExMda20NBQde3aVatWrSo0yGRlZSkrK8t6np6eXuq1AgCc4aqrrrJCiiQdP37c1kph9+7dSkhIUEJCgl599VVaKTiA1waZ1NRUSVKtWrVs22vVqmXtK8jEiRP1t7/9rVRrAwCUDVWqVNHgwYM1ePBgSb+3UvjjxOHU1FTFxsYqNjZWzz//vCpWrKioqCgr2LRq1Uo+Ph6dpVHueW2QKanx48dr7Nix1vP09HSFh4d7sCIAgFPUrVtXd955p+68804ZY7Rz505bK4UTJ05owYIFWrBggSSpRo0atonDV199tYffQfnjtUGmdu3akqRDhw6pTp061vZDhw6pXbt2hR4XEBDAFyEBAC6by+VSkyZN1KRJE/3lL3+xWiksX75ccXFxSkhI0JEjRzR79mzNnj1bktSwYUNbK4ULP1WA+3ltkImIiFDt2rW1aNEiK7ikp6drzZo1euCBBzxbHACg3PHx8VH79u3Vvn17Pfzww1YrhRUrVmjlypXasGGDfv75Z3344Yf68MMPJUmtWrWygk1UVBSLR0qBR4PMqVOntHPnTuv5nj17lJycrKpVq6p+/fp69NFH9eKLL6pJkyaKiIjQc889p7CwMNt3zQAA4AkBAQHq1auXevXqJen332l/bKWwbds2bdq0SZs2bdJbb70lX19fde7c2Qo2PXr04BMEN/Do8uulS5eqT58++baPGDFCM2bMsL4Q7/3339eJEyd0zTXX6N1331XTpk2L/BosvwYAeMJvv/1ma6Xwyy+/2PYHBgaqV69etFIohCO+2fdKIMgAALzB3r17bSuifvvtN9v+ypUrq0+fPurbt6+uv/76Yn2LfVlEkMlDkAEAeBtjjLZu3WprpXDy5EnbmMaNG2vgwIEaOHCgoqKiFBgY6KFqPYMgk4cgAwDwdtnZ2UpKSrKtiDp37py1/6qrrtK1115rBZsGDRp4sNorgyCThyADAHCakydPasmSJVq8eLFiY2N1+PBh2/7IyEgr1PTs2bNMftswQSYPQQYA4GTGGG3atEk//vijli5dquTkZFt/qEqVKum6667TwIEDNWDAANt3rzkZQSYPQQYAUJYcO3ZMixcv1uLFi7V8+fJ8Hbs7dOhg3a3p0qWLY1dCEWTyEGQAAGVVbm6uEhMTtXDhQi1dulSbNm2y7a9atar69++vgQMHqn///qpWrZqHKi0+gkweggwAoLw4dOiQFi1apMWLFysuLk7p6enWPpfLpW7dull3a9q1a+fVDS8JMnkIMgCA8ujcuXNavXq1fvrpJ8XGxiolJcW2v3bt2howYIAGDhyo6667TqGhoR6qtGAEmTwEGQAApF9//VULFy7U4sWLtWrVKp0+fdra5+fnp2uuuca6W9OyZUu5XC4PVkuQsRBkAACwO3PmjOLi4rRo0SLFxsbq559/tu2vX7++FWquvfZaBQcHX/EaCTJ5CDIAAFzcrl279NNPP2nx4sVau3atzp49a+0LCAhQdHS0FWwaN258RWoiyOQhyAAAUHSZmZmKjY217tYcOHDAtr9JkyYaOHCgBg0apN69e5daB2+CTB6CDAAAJWOM0bZt27Rw4UItWbJEiYmJ+VonxMTEWF/GV79+fbe9NkEmD0EGAAD3SE9P15IlS7Ro0SItW7ZMR44cse1v1aqV9RFUjx49Lqt1AkEmD0EGAAD3M8YoOTlZixYt0pIlS7RhwwZb64TQ0FBdd911iomJ0XXXXaeIiIhirYQiyOQhyAAAUPqOHj1qfRnf8uXLdeLECdv+1NRU1apVq8jnK+rvb7+SFgwAAHBetWrVdPvtt+v2229XTk6O4uPj9d133+mDDz6QpFJbwu29300MAAAcydfXV127dtVTTz1lbSutD4AIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEIMgAAwLEuK8icPXtW27dv17lz59xVDwAAQJGVKMhkZmbqz3/+s6666ipFRkbql19+kSQ99NBDmjRpklsLBAAAKEyJgsz48eO1fv16LV26VIGBgdb2mJgYzZ49223F5eTk6LnnnlNERISCgoLUqFEj/eMf/5Axxm2vAQAAnMuvJAfNmzdPs2fPVrdu3eRyuaztkZGR2rVrl9uKe+WVVzR16lTNnDlTkZGRio+P1z333KPQ0FA9/PDDbnsdAADgTCUKMkeOHFHNmjXzbc/IyLAFm8u1cuVKDRkyRIMGDZIkNWzYULNmzdLatWvd9hoAAMC5SvTRUqdOnbRgwQLr+fnw8u9//1vdu3d3T2WSevTooUWLFiklJUWStH79eq1YsUIDBgxw22sAAADnKtEdmZdfflkDBgzQli1bdO7cOb311lvasmWLVq5cqdjYWLcVN27cOKWnp6t58+by9fVVTk6OXnrpJd11112FHpOVlaWsrCzreXp6utvqAQAA3qVEd2SuueYaJScn69y5c2rdurV+/PFH1axZU6tWrVLHjh3dVtx//vMfffrpp/rss8+UmJiomTNn6vXXX9fMmTMLPWbixIkKDQ21HuHh4W6rBwAAeBeXKcUlQJMmTdLo0aNVuXLlEh0fHh6ucePGacyYMda2F198UZ988om2bdtW4DEF3ZEJDw9XWlqaKlWqVKTXzcjIUMWKFSVJW7duLfJxAADgvzIzM9WkSRNJv/8+DgkJKfKx6enpCg0NveTv71L9Zt+XX35Zx44dK/HxmZmZ8vGxl+jr66vc3NxCjwkICFClSpVsDwAAUDaVaI5MUV3uzZ4bb7xRL730kurXr6/IyEglJSXpzTff1L333uumCgEAgJOVapC5XG+//baee+45/c///I8OHz6ssLAw3X///Xr++ec9XRoAAPACXh1kQkJCNHnyZE2ePNnTpQAAAC9E92sAAOBYBBkAAOBYpRpkevXqpaCgoNJ8CQAAUI6VaI7Mt99+K19fX/Xr18+2/YcfflBubq7VQuDbb7+9/AoBAAAKUaI7MuPGjVNOTk6+7cYYjRs37rKLAgAAKIoSBZkdO3aoZcuW+bY3b95cO3fuvOyiAAAAiqJEQSY0NFS7d+/Ot33nzp0KDg6+7KIAAACKokRBZsiQIXr00Ue1a9cua9vOnTv1+OOPa/DgwW4rDgAA4GJKFGReffVVBQcHq3nz5oqIiFBERIRatGihatWq6fXXX3d3jQAAAAUq0aql0NBQrVy5UgsXLtT69esVFBSkNm3aqHfv3u6uDwAAoFAlblHgcrl0/fXX6/rrr3dnPQAAAEVWoo+WHn74Yf3rX//Kt/2dd97Ro48+erk1AQAAFEmJgsyXX36pnj175tveo0cPzZkz57KLAgAAKIoSBZmjR48qNDQ03/ZKlSrpt99+u+yiAAAAiqJEQaZx48b6/vvv823/7rvvdPXVV192UQAAAEVRosm+Y8eO1YMPPqgjR47o2muvlSQtWrRIb7zxhiZPnuzO+gAAAApVoiBz7733KisrSy+99JL+8Y9/SJIaNmyoqVOn6k9/+pNbCwQAAChMiZdfP/DAA3rggQd05MgRBQUFqWLFiu6sCwAA4JJKHGTOq1GjhjvqAAAAKLYSBZmIiAi5XK5C9xfUUBIAAMDdShRkLvzSu+zsbCUlJen777/Xk08+6Y66AAAALqlEQeaRRx4pcPuUKVMUHx9/WQUBAAAUVYm+R6YwAwYM0JdffunOUwIAABTKrUFmzpw5qlq1qjtPCQAAUKgSfbTUvn1722RfY4xSU1N15MgRvfvuu24rDgAA4GJKFGSGDh1qe+7j46MaNWooOjpazZs3d0ddAAAAl1SiIDNhwgR31wEAAFBsJZojk5iYqI0bN1rP58+fr6FDh+qZZ57R2bNn3VYcAADAxZQoyNx///1KSUmR9PuX3w0bNkxXXXWVvvjiCz311FNuLRAAAKAwJQoyKSkpateunSTpiy++UFRUlD777DPNmDGD5dcAAOCKKVGQMcYoNzdXkvTTTz9p4MCBkqTw8HD99ttv7qsOAADgIkoUZDp16qQXX3xRH3/8sWJjYzVo0CBJ0p49e1SrVi23FggAAFCYEgWZyZMnKzExUQ8++KD++te/qnHjxpJ+/0K8Hj16uLVAAACAwpRo+XWbNm1sq5bOe+211+Tr62s9nzVrlgYPHqzg4OCSVwgAAFAIt7YoCAwMlL+/v/X8/vvv16FDh9z5EgAAABa3BpkLGWNK8/QAAKCcK9UgAwAAUJoIMgAAwLEIMgAAwLG8Psjs379fd999t6pVq6agoCC1bt1a8fHxni4LAAB4gRItvy6qBg0a2FYxFdfx48fVs2dP9enTR999951q1KihHTt2qEqVKm6sEgAAOFWx7sj89NNPF92fm5urF1980Xq+adMmhYeHl6wySa+88orCw8M1ffp0denSRREREbr++uvVqFGjEp8TAACUHcUKMgMHDtSDDz6ozMzMfPs2bdqkzp07a+rUqW4r7uuvv1anTp102223qWbNmmrfvr0++OADt50fAAA4W7GCzPLly7Vo0SK1bdtWcXFxkv57F6Zjx45q1qyZNm3a5Lbidu/eralTp6pJkyb64Ycf9MADD+jhhx/WzJkzCz0mKytL6enptgcAACibijVHpmvXrkpKStK4cePUp08f3XfffVq9erX27dunWbNm6eabb3Zrcbm5uerUqZNefvllSVL79u21adMmTZs2TSNGjCjwmIkTJ+pvf/ubW+sAAADeqdiTfQMDA/XPf/5Thw8f1rvvvqvg4GDFx8erWbNmbi+uTp06atmypW1bixYt9OWXXxZ6zPjx4zV27FjreXp6+mXN0wEAAN6r2Muvd+3apd69e2vx4sWaNm2aWrVqpejoaM2fP9/txfXs2VPbt2+3bUtJSVGDBg0KPSYgIECVKlWyPQAAQNlUrCDzzjvvqG3btqpZs6Y2btyo++67T3FxcXr00Ud1xx13aPjw4Tpx4oTbinvssce0evVqvfzyy9q5c6c+++wzvf/++xozZozbXgMAADiXyxSjs2PVqlX19ttv66677sq3b/PmzRoxYoQOHjyo/fv3u63Ab775RuPHj9eOHTsUERGhsWPHatSoUUU+Pj09XaGhoUpLSyvy3ZmMjAxVrFhRkrR161bu6gAAUAKZmZlq0qSJpN9/H4eEhBT52KL+/i7WHJnNmzerTp06Be6LjIzUmjVrrIm57nLDDTfohhtucOs5AQBA2VCsj5b+/Oc/Ky0tzXo+adIk20dJJ06c0KxZs9xWHAAAwMUUK8j88MMPysrKsp6//PLLOnbsmPX83Llz+SbnAgAAlJZiBZkLp9MUY3oNAACA23l992sAAIDCFCvIuFwuuVyufNsAAAA8oVirlowxGjlypAICAiRJZ86c0ejRoxUcHCxJtvkzAAAApa1YQebC/kZ33313vjF/+tOfLq8iAACAIipWkJk+fXpp1QEAAFBsTPYFAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACORZABAACO5aggM2nSJLlcLj366KOeLgUAAHgBxwSZdevW6b333lObNm08XQoAAPASjggyp06d0l133aUPPvhAVapU8XQ5AADASzgiyIwZM0aDBg1STEyMp0sBAABexM/TBVzK559/rsTERK1bt65I47OyspSVlWU9T09PL63SAACAh3n1HZl9+/bpkUce0aeffqrAwMAiHTNx4kSFhoZaj/Dw8FKuEgAAeIrLGGM8XURh5s2bp5tuukm+vr7WtpycHLlcLvn4+CgrK8u2Tyr4jkx4eLjS0tJUqVKlIr1uRkaGKlasKEnaunVrkY8DAAD/lZmZqSZNmkj6/fdxSEhIkY9NT09XaGjoJX9/e/VHS3379tXGjRtt2+655x41b95cTz/9dL4QI0kBAQEKCAi4UiUCAAAP8uogExISolatWtm2BQcHq1q1avm2AwCA8ser58gAAABcjFffkSnI0qVLPV0CAADwEtyRAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjkWQAQAAjuXVQWbixInq3LmzQkJCVLNmTQ0dOlTbt2/3dFkAAMBLeHWQiY2N1ZgxY7R69WotXLhQ2dnZuv7665WRkeHp0gAAgBfw83QBF/P999/bns+YMUM1a9ZUQkKCevfu7aGqAACAt/DqOzIXSktLkyRVrVrVw5UAAABv4NV3ZP4oNzdXjz76qHr27KlWrVoVOi4rK0tZWVnW8/T09CtRHgAA8ADH3JEZM2aMNm3apM8///yi4yZOnKjQ0FDrER4efoUqBAAAV5ojgsyDDz6ob775RkuWLFG9evUuOnb8+PFKS0uzHvv27btCVQIAgCvNqz9aMsbooYce0ty5c7V06VJFRERc8piAgAAFBARcgeoAAICneXWQGTNmjD777DPNnz9fISEhSk1NlSSFhoYqKCjIw9UBAABP8+qPlqZOnaq0tDRFR0erTp061mP27NmeLg0AAHgBr74jY4zxdAkAAMCLefUdGQAAgIshyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMciyAAAAMdyRJCZMmWKGjZsqMDAQHXt2lVr1671dEkAAMALeH2QmT17tsaOHasJEyYoMTFRbdu2Vb9+/XT48GFPlwYAADzMz9MFXMqbb76pUaNG6Z577pEkTZs2TQsWLNBHH32kcePGlcprGmOsf8/MzJSfn9dfJgAAvE5mZqb173/83epOXv0b+uzZs0pISND48eOtbT4+PoqJidGqVasKPCYrK0tZWVnW8/T09GK/7h8vfMeOHYt9PAAAsMvMzFSlSpXcfl6v/mjpt99+U05OjmrVqmXbXqtWLaWmphZ4zMSJExUaGmo9wsPDr0SpAADgIlwuV6mc16vvyJTE+PHjNXbsWOt5enp6scNM9erVdejQIWVlZSkoKKjULj4AAGWZMUaZmZny8fFRjRo1SuU1vDrIVK9eXb6+vjp06JBt+6FDh1S7du0CjwkICFBAQMBlva6Pj49q1qx5WecAAAClz6s/WqpQoYI6duyoRYsWWdtyc3O1aNEide/e3YOVAQAAb+DVd2QkaezYsRoxYoQ6deqkLl26aPLkycrIyLBWMQEAgPLL64PMsGHDdOTIET3//PNKTU1Vu3bt9P333+ebAAwAAMoflymthd1eIj09XaGhoUpLSyuVZV8AAMD9ivr726vnyAAAAFwMQQYAADgWQQYAADiW10/2vVznpwCVpFUBAADwjPO/ty81lbfMB5mTJ09KEq0KAABwoJMnTyo0NLTQ/WV+1VJubq4OHDigkJCQYrUaON/aYN++fax2chOuqftxTd2Pa+p+XFP3Kw/X1BijkydPKiwsTD4+hc+EKfN3ZHx8fFSvXr0SH1+pUqUy+0PiKVxT9+Oauh/X1P24pu5X1q/pxe7EnMdkXwAA4FgEGQAA4FgEmUIEBARowoQJl91JG//FNXU/rqn7cU3dj2vqflzT/yrzk30BAEDZxR0ZAADgWAQZAADgWAQZAADgWOUqyEyZMkUNGzZUYGCgunbtqrVr1150/BdffKHmzZsrMDBQrVu31rfffmvbb4zR888/rzp16igoKEgxMTHasWNHab4Fr+POa5qdna2nn35arVu3VnBwsMLCwvSnP/1JBw4cKO234VXc/XP6R6NHj5bL5dLkyZPdXLX3Ko3ruXXrVg0ePFihoaEKDg5W586d9csvv5TWW/A67r6mp06d0oMPPqh69eopKChILVu21LRp00rzLXid4lzTzZs365ZbblHDhg0v+ue5uP+dHMuUE59//rmpUKGC+eijj8zmzZvNqFGjTOXKlc2hQ4cKHB8XF2d8fX3Nq6++arZs2WKeffZZ4+/vbzZu3GiNmTRpkgkNDTXz5s0z69evN4MHDzYRERHm9OnTV+pteZS7r+mJEydMTEyMmT17ttm2bZtZtWqV6dKli+nYseOVfFseVRo/p+d99dVXpm3btiYsLMz885//LOV34h1K43ru3LnTVK1a1Tz55JMmMTHR7Ny508yfP7/Qc5Y1pXFNR40aZRo1amSWLFli9uzZY9577z3j6+tr5s+ff6XelkcV95quXbvWPPHEE2bWrFmmdu3aBf55Lu45nazcBJkuXbqYMWPGWM9zcnJMWFiYmThxYoHjb7/9djNo0CDbtq5du5r777/fGGNMbm6uqV27tnnttdes/SdOnDABAQFm1qxZpfAOvI+7r2lB1q5daySZvXv3uqdoL1da1/TXX381devWNZs2bTINGjQoN0GmNK7nsGHDzN133106BTtAaVzTyMhI8/e//902pkOHDuavf/2rGyv3XsW9pn9U2J/nyzmn05SLj5bOnj2rhIQExcTEWNt8fHwUExOjVatWFXjMqlWrbOMlqV+/ftb4PXv2KDU11TYmNDRUXbt2LfScZUlpXNOCpKWlyeVyqXLlym6p25uV1jXNzc3V8OHD9eSTTyoyMrJ0ivdCpXE9c3NztWDBAjVt2lT9+vVTzZo11bVrV82bN6/U3oc3Ka2f0R49eujrr7/W/v37ZYzRkiVLlJKSouuvv7503ogXKck19cQ5vVm5CDK//fabcnJyVKtWLdv2WrVqKTU1tcBjUlNTLzr+/D+Lc86ypDSu6YXOnDmjp59+WnfeeWeZ7iVyXmld01deeUV+fn56+OGH3V+0FyuN63n48GGdOnVKkyZNUv/+/fXjjz/qpptu0s0336zY2NjSeSNepLR+Rt9++221bNlS9erVU4UKFdS/f39NmTJFvXv3dv+b8DIluaaeOKc3K/NNI+FM2dnZuv3222WM0dSpUz1djmMlJCTorbfeUmJiYrG6v6Ngubm5kqQhQ4bosccekyS1a9dOK1eu1LRp0xQVFeXJ8hzr7bff1urVq/X111+rQYMGWrZsmcaMGaOwsLB8d3OAC5WLOzLVq1eXr6+vDh06ZNt+6NAh1a5du8BjateufdHx5/9ZnHOWJaVxTc87H2L27t2rhQsXlou7MVLpXNPly5fr8OHDql+/vvz8/OTn56e9e/fq8ccfV8OGDUvlfXiL0rie1atXl5+fn1q2bGkb06JFi3Kxaqk0runp06f1zDPP6M0339SNN96oNm3a6MEHH9SwYcP0+uuvl84b8SIluaaeOKc3KxdBpkKFCurYsaMWLVpkbcvNzdWiRYvUvXv3Ao/p3r27bbwkLVy40BofERGh2rVr28akp6drzZo1hZ6zLCmNayr9N8Ts2LFDP/30k6pVq1Y6b8ALlcY1HT58uDZs2KDk5GTrERYWpieffFI//PBD6b0ZL1Aa17NChQrq3Lmztm/fbhuTkpKiBg0auPkdeJ/SuKbZ2dnKzs6Wj4/915Gvr691B6wsK8k19cQ5vZqnZxtfKZ9//rkJCAgwM2bMMFu2bDH33XefqVy5sklNTTXGGDN8+HAzbtw4a3xcXJzx8/Mzr7/+utm6dauZMGFCgcuvK1eubObPn282bNhghgwZUu6WX7vzmp49e9YMHjzY1KtXzyQnJ5uDBw9aj6ysLI+8xyutNH5OL1SeVi2VxvX86quvjL+/v3n//ffNjh07zNtvv218fX3N8uXLr/j784TSuKZRUVEmMjLSLFmyxOzevdtMnz7dBAYGmnffffeKvz9PKO41zcrKMklJSSYpKcnUqVPHPPHEEyYpKcns2LGjyOcsS8pNkDHGmLffftvUr1/fVKhQwXTp0sWsXr3a2hcVFWVGjBhhG/+f//zHNG3a1FSoUMFERkaaBQsW2Pbn5uaa5557ztSqVcsEBASYvn37mu3bt1+Jt+I13HlN9+zZYyQV+FiyZMkVekee5+6f0wuVpyBjTOlczw8//NA0btzYBAYGmrZt25p58+aV9tvwKu6+pgcPHjQjR440YWFhJjAw0DRr1sy88cYbJjc390q8Ha9QnGta2P8ro6KiinzOsoTu1wAAwLHKxRwZAABQNhFkAACAYxFkAACAYxFkAACAYxFkAACAYxFkAACAYxFkAACAYxFkAACAYxFkADjKjBkzVLlyZev5Cy+8oHbt2nmsHgCeRZABSmjkyJFyuVzWo1q1aurfv782bNhgjXG5XJo3b57tuG+++UZRUVEKCQnRVVddpc6dO2vGjBm2MT///LNcLpd8fX21f/9+276DBw/Kz89PLpdLP//8c766+vXrJ19fX61bty7fviNHjuiBBx5Q/fr1FRAQoNq1a6tfv36Ki4uzxqxfv16DBw9WzZo1FRgYqIYNG2rYsGE6fPjwJa/J+boLeqxevfqSx5fEE088ka8pYXm2ZMkS3XDDDapRo4YCAwPVqFEjDRs2TMuWLStwfPPmzRUQEKDU1NR8+6Kjo+VyuTRp0qR8+wYNGiSXy6UXXnjB3W8BKBaCDHAZ+vfvr4MHD+rgwYNatGiR/Pz8dMMNNxQ6/u2339aQIUPUs2dPrVmzRhs2bNAdd9yh0aNH64knnsg3vm7duvrf//1f27aZM2eqbt26BZ7/l19+0cqVK/Xggw/qo48+yrf/lltuUVJSkmbOnKmUlBR9/fXXio6O1tGjRyX9HnT69u2rqlWr6ocfftDWrVs1ffp0hYWFKSMjo8jX5aeffrKuy/lHx44di3x8cVSsWNFjXdLPnj3rkdctzLvvvqu+ffuqWrVqmj17trZv3665c+eqR48eeuyxx/KNX7FihU6fPq1bb71VM2fOLPCc4eHh+YL2/v37tWjRItWpU6c03gZQPJ5u9gQ41YgRI8yQIUNs25YvX24kmcOHDxtjjJFk5s6da4wx5pdffjH+/v5m7Nix+c71r3/9y0iymrqdbwr37LPPmiZNmtjGNm3a1Dz33HNGktmzZ49t3wsvvGDuuOMOs3XrVhMaGmoyMzOtfcePHzeSzNKlSwt9T3PnzjV+fn4mOzu7qJfB5nzdSUlJFx339ddfm06dOpmAgABTrVo1M3ToUGvfsWPHzPDhw03lypVNUFCQ6d+/v0lJSbH2T58+3YSGhlrPJ0yYYNq2bVvkGj/88EPTsmVLU6FCBVO7dm0zZswYa9/evXvN4MGDTXBwsAkJCTG33XabrVvw+df64IMPTMOGDY3L5TLG/H5t//znP5vq1aubkJAQ06dPH5OcnHzJWk6cOGF8fHzMunXrjDHG5OTkmCpVqpiuXbtaYz7++GNTr169S55r7969xt/f3zz22GMF7i+oAePIkSPNuHHjzHfffWeaNm2ab39UVJR54IEHTLVq1cyKFSus7S+99JK58cYbTdu2bc2ECRMuWRtQmrgjA7jJqVOn9Mknn6hx48YF3iGYM2eOsrOzC7zzcv/996tixYqaNWuWbfvgwYN1/PhxrVixQtLvf4M+fvy4brzxxnznMMZo+vTpuvvuu9W8eXM1btxYc+bMsfZXrFhRFStW1Lx585SVlVXge6hdu7bOnTunuXPnypRSP9kFCxbopptu0sCBA5WUlKRFixapS5cu1v6RI0cqPj5eX3/9tVatWiVjjAYOHKjs7OzLfu2pU6dqzJgxuu+++7Rx40Z9/fXXaty4sSQpNzdXQ4YM0bFjxxQbG6uFCxdq9+7dGjZsmO0cO3fu1JdffqmvvvpKycnJkqTbbrtNhw8f1nfffaeEhAR16NBBffv21bFjxy5aT2hoqNq1a6elS5dKkjZu3CiXy6WkpCSdOnVKkhQbG6uoqKhLvrcvv/xS2dnZeuqppwrc73K5bM9PnjypL774Qnfffbeuu+46paWlafny5fmOq1Chgu666y5Nnz7d2jZjxgzde++9l6wJuCI8HKQAxxoxYoTx9fU1wcHBJjg42EgyderUMQkJCdYY/eGOzOjRo213Ei7Upk0bM2DAAGOM/c7Go48+au655x5jjDH33HOPeeyxx0xSUlK+OzI//vijqVGjhnU35Z///KeJioqyvcacOXNMlSpVTGBgoOnRo4cZP368Wb9+vW3MM888Y/z8/EzVqlVN//79zauvvmq7K3Ex5+sOCgqyrsv5x3ndu3c3d911V4HHp6SkGEkmLi7O2vbbb7+ZoKAg85///McYc3l3ZMLCwsxf//rXAvf9+OOPxtfX1/zyyy/Wts2bNxtJZu3atdZr+fv7W3fcjPn9LlylSpXMmTNnbOdr1KiRee+99y5Z09ixY82gQYOMMcZMnjzZDBs2zLRt29Z89913xhhjGjdubN5///1Lnmf06NGmUqVKtm1z5syx/TfYsGGDte/999837dq1s54/8sgjZsSIEbbjo6KizCOPPGKSk5NNSEiIOXXqlImNjTU1a9Y02dnZ3JGBV+CODHAZ+vTpo+TkZCUnJ2vt2rXq16+fBgwYoL1797rtNe6991598cUXSk1N1RdffFHo34Q/+ugjDRs2TH5+fpKkO++8U3Fxcdq1a5c15pZbbtGBAwf09ddfq3///lq6dKk6dOhgmwPx0ksvKTU1VdOmTVNkZKSmTZum5s2ba+PGjUWuefbs2dZ1Of84Lzk5WX379i3wuK1bt8rPz09du3a1tlWrVk3NmjXT1q1bi/z6BTl8+LAOHDhw0dcODw9XeHi4ta1ly5aqXLmy7bUbNGigGjVqWM/Xr1+vU6dOqVq1atZdr4oVK2rPnj22a1+YqKgorVixQjk5OYqNjVV0dLSio6O1dOlSHThwQDt37lR0dHSR3uOFd1369eun5ORkLViwQBkZGcrJybH2ffTRR7r77rut53fffbe++OILnTx5Mt9527ZtqyZNmmjOnDn66KOPNHz4cOvnDPA0ggxwGYKDg9W4cWM1btxYnTt31r///W9lZGTogw8+yDe2adOmSktL04EDB/LtO3v2rHbt2qWmTZvm29e6dWs1b95cd955p1q0aKFWrVrlG3Ps2DHNnTtX7777rvz8/OTn56e6devq3Llz+Sb9BgYG6rrrrtNzzz2nlStXauTIkZowYYJtTLVq1XTbbbfp9ddf19atWxUWFqbXX3+9yNclPDzcui7nH+cFBQUV+Tzu5K7XDQ4Otj0/deqU6tSpky+4bd++XU8++eQlz9e7d2+dPHlSiYmJWrZsmS3IxMbGKiwsTE2aNLnkeZo0aaK0tDTb6qOKFSuqcePGatCggW3sli1btHr1aj311FPWz0u3bt2UmZmpzz//vMDz33vvvZoyZYrmzJnDx0rwKgQZwI1cLpd8fHx0+vTpfPtuueUW+fv764033si3b9q0acrIyNCdd95Z4HnvvfdeLV26tNBfIJ9++qnq1aun9evX236ZvvHGG5oxY4btb+IXatmy5UVXJFWoUEGNGjUq1qqli2nTpk2hy6VbtGihc+fOac2aNda2o0ePavv27WrZsuVlvW5ISIgaNmx40dfet2+f9u3bZ23bsmWLTpw4cdHX7tChg1JTU+Xn55cvvFWvXv2SdVWuXFlt2rTRO++8I39/fzVv3ly9e/dWUlKStVS/KG699Vb5+/vrlVdeueTYDz/8UL1798738zJ27Fh9+OGHBR7z//7f/9PGjRvVqlWry/5vAbgT9waBy5CVlWX9Dfj48eN65513dOrUqQIn49avX1+vvvqqHn/8cQUGBmr48OHy9/fX/Pnz9cwzz+jxxx+3faTyR6NGjdJtt91m+yK4P/rwww9166235rtbEx4ervHjx+v7779Xt27ddNttt+nee+9VmzZtFBISovj4eL366qsaMmSIpN+/4+bzzz/XHXfcoaZNm8oYo//7v//Tt99+a5vseSlHjx7N970klStXVmBgoCZMmKC+ffuqUaNGuuOOO3Tu3Dl9++23evrpp9WkSRMNGTJEo0aN0nvvvaeQkBCNGzdOdevWtWq8HC+88IJGjx6tmjVrasCAATp58qTi4uL00EMPKSYmRq1bt9Zdd92lyZMn69y5c/qf//kfRUVFqVOnToWeMyYmRt27d9fQoUP16quvqmnTpjpw4IA1qflix54XHR2tt99+W7feeqskqWrVqmrRooVmz56tKVOmFOm91a9fX2+88YYeeeQRHTt2TCNHjlRERISOHTumTz75RJLk6+ur7Oxsffzxx/r73/+e7+flL3/5i958801t3rxZkZGRtn1VqlTRwYMH5e/vX6R6gCvG05N0AKcaMWKEkWQ9QkJCTOfOnc2cOXOsMfrDZN/z5s+fb3r16mWCg4NNYGCg6dixo/noo49sYy61jPmPk33j4+NtE1IvNGDAAHPTTTeZM2fOmHHjxpkOHTqY0NBQc9VVV5lmzZqZZ5991lqmvWvXLjNq1CjTtGlTExQUZCpXrmw6d+5spk+fXqRrcr7ugh6zZs2yxn355ZemXbt2pkKFCqZ69erm5ptvtvadX34dGhpqgoKCTL9+/dy6/HratGmmWbNmxt/f39SpU8c89NBD1r6iLr++UHp6unnooYdMWFiY8ff3N+Hh4eauu+6yTRy+mLlz5xpJZurUqda2Rx55xEgy27ZtK/J7M8aYhQsXmgEDBpiqVasaPz8/U6tWLTN06FDz/fffG2N+nwDs4+NT6ATuFi1aWEu4z0/2LQyTfeENXMaU0hpLAACAUsYcGQAA4FgEGQBFNnr0aNsS4z8+Ro8e7enyCq2tYsWKBX7Z25UQGRlZaE2ffvppkc/z8ssvF3qeAQMGlOI7ALwbHy0BKLLDhw8rPT29wH2VKlVSzZo1r3BFdjt37ix0X926dT2y9Hvv3r2FfitxrVq1FBISUqTzHDt2rNBvCg4KCiq0/xZQ1hFkAACAY/HREgAAcCyCDAAAcCyCDAAAcCyCDAAAcCyCDAAAcCyCDAAAcCyCDAAAcCyCDAAAcKz/D1wZH5VW7gpaAAAAAElFTkSuQmCC\n", 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"version": "3.9.15" }, "vscode": { "interpreter": { diff --git a/examples/02-optimization.ipynb b/examples/02-optimization.ipynb index 5ab55284..dc9994bd 100644 --- a/examples/02-optimization.ipynb +++ b/examples/02-optimization.ipynb @@ -410,2456 +410,74 @@ "output_type": "stream", "text": [ "Running NSGAII\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpte7rtgbb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbw_a07ga.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcai3gtcb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0rx1ukb1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx54dt31z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjvtrgz76.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeei_hr_w.lp\n", - "Reading time = 0.01 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmperxeuiiq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv64q7317.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoe450lfd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoge27tmw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpilcu0p17.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqe1d4qt7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr069rerl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpws4sg3ie.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", "Eval(s)| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev|\n", - " 100| 0.000000 0.266637 0.000000 0.003583 0.027207| 0.000000 1.652859 0.000000 0.023762 0.172297|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpujj1ubjc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpteojaoia.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxkdnw8qy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwk3x6ydl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkjtmu9ok.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnxagy8f4.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptlheg8h4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyd9khmgc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpybd27bqa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2m4hx4e7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsxo0bixu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphe15lz8t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3tmcsgwf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu7exmssu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoxs15ovp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 200| 0.000000 0.266637 0.000000 0.008030 0.039996| 0.000000 1.652859 0.000000 0.052247 0.249464|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvte580km.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxnjw6d2e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpysighqm3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5d84bovn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsxq1xs0a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphugwrm6n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3b83w8pg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb1wtot9i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxyjub232.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi76t46o9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcykvv5xo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpccv7yrfb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe5tys77g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_kofzvzw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8_6h10t_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 300| 0.000000 0.266637 0.000000 0.025462 0.067582| 0.000000 2.379439 0.000000 0.177580 0.471131|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps2jbzbz7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmponmbdyl1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkktqgyal.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy8x1qvdz.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi9bvom15.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8fsr6lh2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbcvdlkeu.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprzteqv78.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3nh_hl6h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuh3vhmwr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxs84897n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi57idl35.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpawjdx998.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg3__3n8y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd_8rjstw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 400| 0.000000 0.266637 0.000000 0.063574 0.092761| 0.000000 2.379439 0.000000 0.450969 0.640449|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe8b0i3fl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptwf4se_p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw54va_ok.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqecm86cr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3ksdfjjt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwl6mrnwy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuleb18w3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnmrm3qx6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_ekhhv_y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpftkli3_p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4nvivu62.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpww3xqp1t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe929jidj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz0zl1v1n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph7rp0h5j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 500| 0.043382 0.331251 0.166214 0.168163 0.091792| 0.407556 4.648112 1.652859 1.231874 0.666502|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpemc3ge9w.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8g13v5m_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_bsznvqt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpamdhls7u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_j1qx_4m.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnr9q9rig.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqvvlst_i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3zry6vel.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqy42om95.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmgfy4has.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1emzipjn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9pvt9am4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwu_n35pk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuu1haxdq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1rl2pa0t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 600| 0.166214 0.331251 0.266637 0.256412 0.030199| 1.652859 4.648112 1.652859 1.722319 0.333765|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp9scbuxh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyqjge5ke.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyholnapw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjfy4l1pb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb1n1k94_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4jplyz5_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5zrf9xtz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp6tn_kky.lp\n", - "Reading time = 0.00 seconds\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpji_btvsp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsx23sipj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkg9qhcvm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy_tsk12q.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpznaaczm4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb1t1ns2d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr3zefr7q.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 700| 0.229993 0.331251 0.266637 0.265730 0.012777| 1.652859 4.648112 1.652859 1.756359 0.447654|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph48o6m7c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl37on3vu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk0iqngg2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi6apktjk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv_bu_d5o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi01bca_p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0ulq9aim.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjza0v0xs.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo8ycz2yh.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdxa2hqgt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3214sx_o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcfxc0lnr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvk2ylj1z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5hckg1q8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpncfdlocz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 800| 0.229993 0.331251 0.266637 0.266010 0.014794| 1.652859 4.648112 1.652859 1.793577 0.535069|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2h6f4p06.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk0ee3qfa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph6axvym6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzll10l_z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsi24garz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf_b1itpt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl5cucr52.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsgjz_oxq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvxu7eidt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc6l4kuec.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgoaqnu3e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmjjij00i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn0yj3jke.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp47uzzeel.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpil2ata9w.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 900| 0.229993 0.841615 0.266637 0.277159 0.059521| 1.652859 7.055392 1.652859 1.953792 0.961413|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphv8pvzdy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc2f_1xa4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkpgxurdx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpznrov7h5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp400xpsfv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdn0g58ty.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6i5k0dc5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl87ppzzv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3ewslsuy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6o_f614c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoine9k8l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0l1xwgj2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyxn9z68k.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmporlcm3qb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb5lqgnpo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1000| 0.229993 0.841615 0.266637 0.292506 0.099232| 1.652859 7.055392 1.652859 2.241579 1.338030|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkr5_2k6x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz589ympt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4f2axco8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnmxq_mf8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzijn8v5z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpppihur3e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpukoa_441.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppi9o04ij.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt9eamo4y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbnwc2y74.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpen1gihns.lp\n", - "Reading time = 0.01 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe91ccmnx.lp\n", - "Reading time = 0.01 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsklfv1l2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj_ha8bpd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplj74gkgw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1100| 0.057262 0.841615 0.266637 0.312801 0.138114| 1.652859 7.513730 1.652859 2.701906 1.724314|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqauerl9k.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu328jshb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpft2wzmgj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa_yvtcse.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvihfc7td.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyno09zq1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptkifm5dq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3yyy4z5s.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnr3ojqw_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl773ksu9.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6plg1zbm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4v91ch4c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5wd1trcq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi0hgnftt.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj85b1n5t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1200| 0.057262 0.841615 0.331251 0.395240 0.215601| 1.652859 7.513730 4.648112 4.233606 1.991646|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcnxsme90.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnpf97spl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpks2vow3z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphkftvai1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp47bbnxbd.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptbzmu7m5.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoxao5uw_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptm38wlhd.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzg013oub.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp_4d3bhd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprpv917kr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa5um3npm.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9926woug.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzqo0oiih.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr7xveo7z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1300| 0.057262 0.841615 0.331251 0.529584 0.289398| 4.648112 7.513730 7.055392 6.065015 1.217963|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprqr8as4g.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptzwh_nwh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb7g7k7h2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8_dxifwd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4vvgjmmi.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmply38imi2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgmco0mks.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph7v6adkv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuxee790c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuf04wawg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaucdwtv4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmsitdg4j.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvmptx366.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmbqjq0yz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpprszcx25.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1400| 0.057262 0.841615 0.841615 0.825731 0.109790| 7.055392 7.513730 7.055392 7.065727 0.064521|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8vxx5ar2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2d3q49h8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7olqprjt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3yo1nxic.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3v7sc05t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpme3_sea0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8b6im0lj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6d43ddi1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgtdgji11.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyyb0feli.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7ye3dkr4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpepqe5mri.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_mokms31.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp94im1rr0.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8e3z0xjx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1500| 0.057262 0.841615 0.841615 0.817789 0.133759| 7.055392 7.513730 7.055392 7.070895 0.078513|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2h1_8ir7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphbt6s5pp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_0rqomzx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnyvdvkq4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphi1jwycw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd2mh1ezx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp14mkey9k.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu8clykvh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjst39zag.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjc_5dfyq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpme_3wde9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2mz1zi4k.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0y_vkzev.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp492tf7ez.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwoph2uii.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1600| 0.057262 0.915066 0.841615 0.810581 0.153958| 7.055392 8.403136 7.055392 7.089540 0.159805|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4_kky25u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7f5i79bj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmx7aauxw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt9dvp0zt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt12a8i5h.lp\n", - "Reading time = 0.00 seconds\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp50mr4vxp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl8rvge4p.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2ftx90l7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx01ma0cl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7mujj77g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcs4_afmo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcu2xmx5f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfc2m2ixg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp97dwsb09.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi8f9yq4x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1700| 0.057262 0.915066 0.841615 0.802639 0.171173| 7.055392 8.403136 7.055392 7.094708 0.165205|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi5ecplv6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp93dw72sa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz6_nblgy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoze5wo4a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiu3g0hvl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm345rner.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyyv6iih9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9bp7dxuj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt9c924px.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgjiinmc2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps07l9lsj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpljqlazuy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphgtac2bw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps_5qm33h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplzvs8_qt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1800| 0.057262 0.915066 0.841615 0.794626 0.186453| 7.055392 8.403136 7.055392 7.100299 0.170220|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwm4fb555.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsiahnlud.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvlnsetpl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn_1lav23.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptzvgugyg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbpn602xl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplkf7q5n1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpby3kftzo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf_o7skjx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmputzbieal.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm_7ketvq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkmh4ik3a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiowg_8v6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpawurht1l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp27bg7pex.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1900| 0.036139 0.915066 0.841615 0.779928 0.214285| 7.055392 8.403136 7.055392 7.138205 0.254813|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpup1mds4q.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt1p54wcw.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq7wyqsv5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4oje4su1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi24b9dqt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwrbp9ds_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnxb8zqxk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp41lwca88.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpck81o_bp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpngce06no.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvjajy7hd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4s49oo5v.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9_m487e9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkwwfp6la.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzp7z90rw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2000| 0.036139 0.915066 0.841615 0.777790 0.228550| 7.055392 8.403136 7.055392 7.251615 0.425147|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwzhh3pe1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp67fu6ydg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd8zb8gzl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl8xe_1zi.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8bmq4llg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj8b1480k.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpns6lr8r6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkm8vtzq4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptg03vu20.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq4wvqiqh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbuyxjnk8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpymfipt57.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5rvgf8bj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjvgtckaa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfo96xae3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2100| 0.036139 0.915066 0.841615 0.782286 0.244820| 7.055392 8.442937 7.113810 7.515256 0.596885|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7t_7e0hn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpomz37x1l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0ps0cfrf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq9fr3fkx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp65wfpeyc.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplmwjh44d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeypzlekf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd0mqp4mc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4mzd6_6n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp91xhij36.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw0py7ula.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi6nolz_5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuc4hj8dw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpojuwwtr9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjw0djavh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2200| 0.036139 0.915066 0.915066 0.856735 0.187906| 7.055392 8.442937 8.403136 8.151969 0.500252|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj9vixwon.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppwnnylu6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp734s667r.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpopaypksd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa4_27_l4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp824p99yn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjixrwqpf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuoj3pkx1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp32pk_dhq.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq7xmds06.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphle68i86.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7gg0t91h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo6aq_1nd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptcjtw_wd.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnay_ocn_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2300| 0.797250 0.915066 0.915066 0.911285 0.013027| 8.403136 8.442937 8.403136 8.408474 0.012250|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpggyclkbx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpalng4wyb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjil9cv8u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4rg1ae3z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp75whww2x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1n0cjlj6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9i3h0jz9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj1dz0hbf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf7i79one.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpikc4muib.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_qco136h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1spu_up6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsytjmg6p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp86sq02a1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7uswec8s.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2400| 0.797250 0.915066 0.915066 0.903101 0.025618| 8.403136 8.442937 8.403136 8.416654 0.016618|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpczrioh6f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvf1ymjtg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp63rhp1mt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq99pssay.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_u5cq7o2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzsu92kj0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt40wa8kl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbgdta45c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptytses6y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa4qlwhzc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz5530e5g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy4f8ocr7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2solchot.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqadnv9az.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnugrh1rb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2500| 0.797250 0.915066 0.897709 0.894480 0.032351| 8.403136 8.549470 8.436073 8.425638 0.020624|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprpkv_00n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprm66_5tc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiy4ojhi2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxss7ayk3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpohnykwth.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw8ixqs8k.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_yknniwm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw1duwg9o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_w1ek3p4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfgphb7vw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4_uk9xvp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe_7p1896.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf2nsoq0j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfcq3rmba.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9ifizlry.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2600| 0.797250 0.915066 0.897709 0.898008 0.019819| 8.403136 8.549470 8.436073 8.431756 0.025565|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpncjtijqz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4cfre8nk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6tt0_qrg.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2viq0dkm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv9b4vojl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdhusf3ui.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7nxfxj9k.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjhatv4lx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn5bp2m_a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1y9fyvks.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq49k9ozr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp61u7niag.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjfhqxq8r.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg8qfv8lt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpywrdf6qb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2700| 0.752342 0.915066 0.897709 0.902361 0.020712| 8.403136 8.700666 8.436073 8.427067 0.038319|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpttxdje30.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3v68057p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt5cixpsk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqqu3i2mj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5pv0srqz.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp840i7xj2.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprtp6_mg4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm9tfglaf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptfpaxbsk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4r1_lxl9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr34nd36r.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_djb5r_n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvnx4_16f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp14euoqk4.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpou0pnf05.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2800| 0.752342 0.915066 0.915066 0.904190 0.031528| 8.403136 8.700666 8.403136 8.423331 0.057992|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsmxxqhxa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpav0d7sim.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmksgi0cx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcea18jmi.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4wrpy_i1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn5sjbswz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo91m3h3_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfo7dc96z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvijrgbtq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpji_zq1pp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6wmckxi_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5j6b1fcf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7mvclf6e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd9xb1zqo.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdwtbkx0u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 2900| 0.752342 0.915066 0.915066 0.901231 0.035554| 8.403136 8.700666 8.403136 8.428806 0.065362|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp32l01258.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo0kpiugh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6yybar8l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3zlua5_6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplbll1g5s.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpflrkpux8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3dl487_g.lp\n", - "Reading time = 0.00 seconds\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5dxn86w8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpakhf5czg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2hwr2i_p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbbrrwyuf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4kdxhave.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprh9ctsla.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpht3vesrk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4n891lic.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3000| 0.752342 0.915066 0.915066 0.899430 0.038456| 8.403136 8.700666 8.403136 8.432111 0.070623|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_dm84prq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpntwxfyib.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3cxvluk9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnwe60v8e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaigzgux2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7p5s1d7v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxwyvic9m.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpng5ulcj_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp62oj582i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_a1wemgt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxoqyn_md.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwwktrf8l.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3jzt0aqc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1u274orz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu_7yj77y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3100| 0.752342 0.915066 0.915066 0.897970 0.041450| 8.403136 8.700666 8.403136 8.434757 0.076075|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplabrtt21.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0bassyae.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0p9rj75x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpguvf79il.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe5khulvq.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcg66wydy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphlit_t9y.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprjbv45ro.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp074tvl47.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptrqgz49v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6i3qklsl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1wone4_x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppj76cfhq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprfw1x7pu.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4sh3bmjk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3200| 0.752342 0.915066 0.915066 0.895559 0.044228| 8.403136 8.700666 8.403136 8.439195 0.081157|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwd5hli4u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsl2f8ymn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv447cpn9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgm9bwmo6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3ptln682.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8yoc27y8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsjbw1qp2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvn5fefe6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppsopa264.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx8f5m8j5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphgedh1kd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzl2xy9rm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqur986jn.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgy3ke4dk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcplka6oo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3300| 0.752342 0.915066 0.915066 0.892773 0.046689| 8.403136 8.700666 8.403136 8.444342 0.085663|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxkxskw70.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkgr20i47.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1bk7y1gj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvyfejr61.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq34oko0n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkyd4eb0k.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfctl_ucp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpagle5qep.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprirv0qis.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuktux3lm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkvtil6y1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiq05p5nr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp48p9svdb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvmov5x4g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpogv7f0la.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3400| 0.752342 0.915066 0.897709 0.879909 0.051793| 8.403136 8.700666 8.436073 8.468262 0.094960|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpldj0maf1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3il7sb28.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxnxe_5b3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnryoz6yf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph7nxofst.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp08i5vli6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp057kmn07.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1rqff0wc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplg0zpn43.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp33slzm_e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjgrv9_si.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmporvg54n9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvrnvy0v4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzrefllsu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu3c07rbi.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3500| 0.752342 0.915066 0.877589 0.854879 0.053230| 8.403136 8.700666 8.473872 8.514744 0.097114|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsuviu2h6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmi025wkt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi9erunjw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu70qzayg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr92edfdu.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_rb7gb0l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc7i5a2a8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdyodm6_p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk89zabg3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfi5_qyig.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5x4h6oo5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplib3p15f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnoo0y3xh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmproh4qkc6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpue5zhpcp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3600| 0.752342 0.915066 0.877589 0.856842 0.052481| 8.403136 8.700666 8.473872 8.511153 0.095772|\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplfgeqqdb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt8x822rq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt45iq2oh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu2b6xu5z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3gafburu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp0lp4rrt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvl5aod14.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgu6pwvaw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9569bbmm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy2u43o5u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgnfmcms3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwc47hrp3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuo8bhyyx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_1s33j11.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjstga72b.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3700| 0.752342 0.915066 0.877589 0.856507 0.053560| 8.403136 8.700666 8.473872 8.511720 0.097712|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwzwyyedw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0fkhnmgu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptly3lnuu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5dt7o0g8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2gh_5zo_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphtl3wju1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdebyhp_c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxvx6arb3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0p5hpfd2.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnz5qhqq8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3yp967qy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb1rt76an.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_k0zren2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfnabkqgw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp81vmb2lu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3800| 0.752342 0.915066 0.877589 0.854952 0.054355| 8.403136 8.700666 8.473872 8.514555 0.099140|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj2j7a27q.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk9bori2p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa2wpvu0c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpspys0m1m.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv2oldszu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe0l7xy4g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzr73gkx4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8js8wc60.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_hhxjzgn.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp46m7u7c2.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0ywvcfcr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdsgu5ahw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzyrp5f5p.lp\n", - "Reading time = 0.01 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6iyyx1oa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc9lw_3fz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 3900| 0.752342 0.915066 0.877589 0.855460 0.054457| 8.403136 8.700666 8.473872 8.513610 0.099324|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp69774j4o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo4m9erdb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprs18fjtz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfc08xfuo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2tvfe0n7.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdgx4nn0z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6vl1vivb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwj_vdexy.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo_cdejo1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5eqgu39m.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp07adwt3o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1fbq9yva.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp21wy1kek.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplp1h48ht.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcz3ks3kf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4000| 0.752342 0.915066 0.877589 0.855560 0.054543| 8.403136 8.700666 8.473872 8.513421 0.099490|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp306obo7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgvr6_qhy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa_7xw522.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4_nx24d0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfvvzfvep.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqlyug4k9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9olgclqa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzpxcc7h6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc5244icq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5vnmkcbm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp60wb4zxq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8j61n73y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu2_ruejw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8rb_rrtg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmml7lilw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4100| 0.752342 0.915066 0.877589 0.855050 0.054497| 8.403136 8.700666 8.473872 8.514366 0.099415|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgpxxteaq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf75r5hd2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjckfrx6z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjcx16knf.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6rg27heb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppjwucolr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt1sxfxij.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzc1zspr6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkzzp3c6c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp829i20lf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpec2bsdua.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmc1c4wtt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsrji4acp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5qxvo1l0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjgizhayk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4200| 0.718930 0.915066 0.877589 0.853046 0.055990| 8.403136 8.758902 8.473872 8.517993 0.102050|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0ws3qj51.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzg6o6gad.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpicjrg3qt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphi6epglk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4eus96xj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpckwo7bez.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_yhgxd0l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfwwead82.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuvks2184.lp\n", - "Reading time = 0.00 seconds\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd6x4lphd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx1n_owd5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsrhra33t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpibxd7p55.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmeohc48g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwl_8_1fi.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4300| 0.718930 0.915066 0.877589 0.850198 0.058194| 8.403136 8.758902 8.473872 8.523132 0.105969|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpugnx7b3e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt4bulkmu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnnelb1sy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyiv3nq4b.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6m9gkiuv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplw6pghzv.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0w6ozhqj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcjs1du_j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvyhow13i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_di1_85d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpern64d_2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr8bswcff.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkgs7tt2o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuzsd96hc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd8faanw_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4400| 0.718930 0.915066 0.877589 0.848654 0.058086| 8.403136 8.758902 8.473872 8.525981 0.105819|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnturxqsz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp49m6pxn1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0luh1uei.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp74gcpfhx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0p4ua8fa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdgmmlxp_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6fk35m2p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb0eji22u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr4mwz1il.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg1ij7kgi.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpixj47g0a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa94aazga.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpstj5acrq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4ef453bq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_zp4hyn8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4500| 0.718930 0.918156 0.836701 0.810399 0.052094| 8.403136 8.758902 8.549470 8.597438 0.092297|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpign8phwz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpugeli3z4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp707zz2ih.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpor02p1c4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcs6ix0x3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdf_8pc4c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfwf0ik9o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8sw_atp3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpux971uv8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr_hbbnxb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpodcsep6t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyi3rv4wx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplcp798vl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr9dgc79s.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc52pxbkn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4600| 0.718930 0.918156 0.752342 0.780144 0.054124| 8.403136 8.758902 8.700666 8.652970 0.094683|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppu0byqc3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_3ridi_2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjcfxxx56.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3h6hpjoy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqcyp8jdk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph1onxc09.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvs91u9nn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqgk5g2jq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzgqj0us9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8zw6ctu1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpofhr2dm0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3k4vfrgp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp86vqc86z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7ar5gunc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_mrkz7fg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4700| 0.718930 0.918156 0.752342 0.755906 0.027920| 8.533954 8.758902 8.700666 8.699554 0.027380|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn394n09r.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9yocbdut.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcb3a5mu4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnvxr10os.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxyq1eves.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw6sy0ivr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp36qo41lz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqbcqzswo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb4bt2008.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaqiob3zb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvucm1qo6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp815hwfjv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp26_4sw3y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxfhdl2kb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpswgw449l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4800| 0.718930 0.918156 0.752342 0.758183 0.033727| 8.533954 8.758902 8.700666 8.698135 0.032697|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3n8wew0d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk4on8du6.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd7akw8i3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcwhxvsjt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5j_4cicn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_hlcjwfw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvju5qooa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn82s_o49.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6b34osmp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbtmyf85q.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkk61bpl1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppvuufe2f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvia_vhkq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp91_emthr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0ep73fhk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 4900| 0.718930 0.918156 0.752342 0.759494 0.037504| 8.533954 8.758902 8.700666 8.697073 0.037074|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxkct5b6i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd30siwjw.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcrr1wb4x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8gquk075.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph7hq3_5u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_xhco5u4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphdl4y4yp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprlp55z95.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr1prgyhj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl0e2zcaw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxqxlw3uq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptw3o7btk.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy9mkx91o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw1uj_y7f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpozfnstmp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 5000| 0.718930 0.918156 0.752342 0.772561 0.052878| 8.403136 8.800405 8.700666 8.684382 0.065736|\n", - "[0.9181564151188527, 8.533954360914198];{'b2463': 0, 'b2914': 0.03125, 'b3956': 16, 'b1849': 0.0625} simplified to [0.9181564151188526, 8.533954360914194];{'b3956': 16, 'b2463': 0}\n", - "[0.9181564151188527, 8.533954360914198];{'b2463': 0, 'b3956': 16, 'b1819': 0.03125, 'b1818': 0.0625} simplified to [0.9181564151188526, 8.533954360914194];{'b3956': 16, 'b2463': 0}\n", - "[0.9181564151188527, 8.533954360914198];{'b3870': 0, 'b2463': 0, 'b3956': 16} simplified to [0.9181564151188526, 8.533954360914194];{'b2463': 0, 'b3956': 16}\n", - "[0.9181564151188527, 8.533954360914198];{'b2914': 0.03125, 'b2463': 0, 'b1818': 0.0625, 'b3956': 16, 'b4154': 0.5} simplified to [0.9181564151188526, 8.533954360914194];{'b2463': 0, 'b3956': 16}\n", - "[0.7747403052620708, 8.800405071091363];{'b2285': 0.5, 'b3403': 16, 'b3870': 32, 'b2463': 0, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7747403052620707, 8.800405071091362];{'b2463': 0, 'b3956': 16, 'b3870': 32}\n", - "[0.911598188163385, 8.546575594684317];{'b2463': 0, 'b1818': 0.0625, 'b1297': 2, 'b3956': 16, 'b1819': 0.03125} simplified to [0.9115981881633864, 8.546575594684327];{'b2463': 0, 'b1297': 2, 'b3956': 16}\n", - "[0.9181564151188527, 8.533954360914198];{'b2914': 0.03125, 'b2279': 0.25, 'b2463': 0, 'b1849': 0.0625, 'b3956': 16} simplified to [0.9181564151188526, 8.533954360914194];{'b2463': 0, 'b3956': 16}\n", - "[0.7189300114819255, 8.758902363730876];{'b3403': 0, 'b0115': 0, 'b3870': 32, 'b2914': 2, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7189300114819218, 8.75890236373083];{'b3403': 0, 'b3956': 16, 'b3870': 32, 'b2914': 2}\n", - "[0.9150663940283786, 8.40313577537787];{'b2914': 2, 'b3956': 16, 'b1380': 0.0625, 'b1818': 0.0625} simplified to [0.9150663940283817, 8.403135775377892];{'b3956': 16, 'b2914': 2}\n", - "[0.9150663940283786, 8.40313577537787];{'b2285': 0.5, 'b3870': 0.25, 'b2914': 2, 'b1818': 0.0625, 'b3956': 16} simplified to [0.9150663940283817, 8.403135775377892];{'b2914': 2, 'b3956': 16}\n", - "[0.8251965952132049, 8.570459156801919];{'b0115': 0, 'b2914': 2, 'b2463': 0, 'b3870': 16, 'b3956': 16} simplified to [0.8251965952132045, 8.570459156801915];{'b2914': 2, 'b2463': 0, 'b3870': 16, 'b3956': 16}\n", - "[0.7523421321470498, 8.700665974296033];{'b3870': 32, 'b2914': 2, 'b3403': 0.0625, 'b1818': 0.0625, 'b1136': 0.5, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7510429616263203, 8.702947161544493];{'b2285': 0.5, 'b3870': 32, 'b2463': 0, 'b2914': 2, 'b3956': 16} simplified to [0.7510429616263212, 8.702947161544502];{'b3870': 32, 'b2463': 0, 'b2914': 2, 'b3956': 16}\n", - "[0.7523421321470497, 8.700665974296037];{'b3403': 16, 'b3870': 32, 'b2914': 2, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b3870': 32, 'b2914': 2, 'b3956': 16}\n", - "[0.7523421321470497, 8.700665974296037];{'b3403': 16, 'b3870': 32, 'b2914': 2, 'b4232': 0.0625, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7510429616263203, 8.702947161544493];{'b3403': 16, 'b3870': 32, 'b2463': 0, 'b2914': 2, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7510429616263212, 8.702947161544502];{'b3956': 16, 'b3870': 32, 'b2463': 0, 'b2914': 2}\n", - "[0.7523421321470497, 8.700665974296037];{'b2285': 0.5, 'b3870': 32, 'b2925': 0.125, 'b2914': 2, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b3870': 32, 'b2914': 2, 'b3956': 16}\n", - "[0.7189300114819255, 8.758902363730876];{'b1818': 0.25, 'b3403': 0, 'b0115': 0, 'b3870': 32, 'b2914': 2, 'b3956': 16} simplified to [0.7189300114819218, 8.75890236373083];{'b3403': 0, 'b3956': 16, 'b3870': 32, 'b2914': 2}\n", - "[0.7510429616263203, 8.702947161544493];{'b0727': 4, 'b3870': 32, 'b2463': 0, 'b2914': 2, 'b3956': 16} simplified to [0.7510429616263212, 8.702947161544502];{'b3870': 32, 'b2463': 0, 'b2914': 2, 'b3956': 16}\n", - "[0.7523421321470497, 8.700665974296037];{'b2285': 0.5, 'b3870': 32, 'b2914': 2, 'b3403': 0.0625, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7523421321470498, 8.700665974296033];{'b3870': 32, 'b2914': 2, 'b1818': 0.0625, 'b1136': 0.5, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b3870': 32, 'b2914': 2, 'b3956': 16}\n", - "[0.7523421321470497, 8.700665974296037];{'b2914': 2, 'b3956': 16, 'b1818': 16, 'b3870': 32} simplified to [0.7523421321470497, 8.700665974296035];{'b3956': 16, 'b3870': 32, 'b2914': 2}\n", - "[0.7523421321470497, 8.700665974296037];{'b2914': 2, 'b3956': 16, 'b3870': 32, 'b1818': 0.0625} simplified to [0.7523421321470497, 8.700665974296035];{'b3956': 16, 'b3870': 32, 'b2914': 2}\n", - "[0.7523421321470497, 8.700665974296037];{'b2285': 0.5, 'b3403': 16, 'b3870': 32, 'b2914': 2, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7523421321470497, 8.700665974296037];{'b4232': 32, 'b3870': 32, 'b2914': 2, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b3870': 32, 'b2914': 2, 'b3956': 16}\n", - "[0.7523421321470497, 8.700665974296037];{'b2285': 0.5, 'b3870': 32, 'b2914': 2, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b3870': 32, 'b2914': 2, 'b3956': 16}\n", - "[0.7523421321470497, 8.700665974296037];{'b3870': 32, 'b2914': 2, 'b3403': 0.0625, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b3870': 32, 'b2914': 2, 'b3956': 16}\n", - "[0.7523421321470497, 8.700665974296037];{'b2285': 0.5, 'b3403': 16, 'b3870': 32, 'b2914': 2, 'b3956': 16, 'b1818': 8} simplified to [0.7523421321470497, 8.700665974296035];{'b3870': 32, 'b2914': 2, 'b3956': 16}\n", - "[0.7523421321470497, 8.700665974296037];{'b3870': 32, 'b0727': 0, 'b2914': 2, 'b4232': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b3870': 32, 'b2914': 2, 'b3956': 16}\n", - "[0.7523421321470497, 8.700665974296037];{'b3403': 4, 'b3870': 32, 'b2914': 2, 'b4232': 0.0625, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7523421321470497, 8.700665974296037];{'b0116': 0.03125, 'b3403': 16, 'b3870': 32, 'b2914': 2, 'b4232': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7523421321470497, 8.700665974296037];{'b3870': 32, 'b2914': 2, 'b4232': 0.0625, 'b1818': 0.0625, 'b0727': 8, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "[0.7523421321470497, 8.700665974296037];{'b3870': 32, 'b2914': 2, 'b3403': 0.0625, 'b0729': 32, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7523421321470497, 8.700665974296037];{'b2285': 0.5, 'b1611': 16, 'b3870': 32, 'b2914': 2, 'b4232': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7523421321470497, 8.700665974296037];{'b3403': 16, 'b3870': 32, 'b2278': 0.125, 'b2914': 2, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7523421321470497, 8.700665974296037];{'b0727': 0.03125, 'b3870': 32, 'b2914': 2, 'b4232': 0.0625, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7523421321470497, 8.700665974296037];{'b2285': 0.5, 'b2463': 0.25, 'b3870': 32, 'b2914': 2, 'b1818': 0.0625, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n", - "[0.7523421321470497, 8.700665974296037];{'b2285': 0.5, 'b1818': 0.25, 'b3403': 16, 'b3870': 32, 'b2914': 2, 'b3956': 16} simplified to [0.7523421321470497, 8.700665974296035];{'b2914': 2, 'b3956': 16, 'b3870': 32}\n" + " 100| -0.000000 0.266637 0.000000 0.004811 0.031423| -0.000000 1.688172 0.000000 0.035772 0.234727|\n", + " 200| -0.000000 0.266637 0.000000 0.005777 0.031997| -0.000000 1.688172 0.000000 0.040494 0.236329|\n", + " 300| -0.000000 0.266637 0.000000 0.017369 0.057077| -0.000000 1.688172 0.000000 0.116406 0.395763|\n", + " 400| -0.000000 0.266637 0.000000 0.043143 0.081472| -0.000000 1.688172 0.000000 0.294911 0.583516|\n", + " 500| -0.000000 0.266637 0.048280 0.113694 0.102973| -0.000000 1.688172 0.236123 0.781527 0.742375|\n", + " 600| 0.019083 0.266637 0.266637 0.223272 0.056129| 0.236123 1.688172 1.652859 1.629045 0.210819|\n", + " 700| 0.166214 0.266637 0.266637 0.264495 0.014071| 1.652859 1.688172 1.652859 1.653662 0.004977|\n", + " 800| 0.166214 0.266637 0.266637 0.264344 0.014080| 1.652859 1.688172 1.652859 1.653772 0.005006|\n", + " 900| 0.166214 0.266637 0.266637 0.263926 0.014102| 1.652859 1.688172 1.652859 1.654076 0.005084|\n", + " 1000| 0.166214 0.266637 0.266637 0.262903 0.014083| 1.652859 1.688172 1.652859 1.654820 0.005166|\n", + " 1100| 0.166214 0.266637 0.259961 0.260376 0.013973| 1.652859 1.688172 1.657713 1.656655 0.005267|\n", + " 1200| 0.166214 0.266637 0.259961 0.259817 0.010806| 1.652859 1.688172 1.657713 1.657432 0.004918|\n", + " 1300| 0.166214 0.266637 0.259961 0.259947 0.010829| 1.652859 1.688172 1.657713 1.657338 0.004937|\n", + " 1400| 0.166214 0.266637 0.259961 0.260656 0.010091| 1.652859 1.688172 1.657713 1.656829 0.004005|\n", + " 1500| 0.166214 0.266637 0.259961 0.260742 0.010105| 1.652859 1.688172 1.657713 1.656767 0.004018|\n", + " 1600| 0.166214 0.266637 0.259961 0.260777 0.010111| 1.652859 1.688172 1.657713 1.656741 0.004023|\n", + " 1700| 0.166214 0.266637 0.259961 0.260813 0.010116| 1.652859 1.688172 1.657713 1.656715 0.004028|\n", + " 1800| 0.166214 0.266637 0.263788 0.260569 0.014166| 1.652859 1.688172 1.654934 1.656513 0.005507|\n", + " 1900| 0.166214 0.266637 0.263722 0.261677 0.010230| 1.652859 1.688172 1.654982 1.656087 0.004119|\n", + " 2000| 0.166214 0.266637 0.263722 0.261187 0.010822| 1.652859 1.688172 1.654982 1.656439 0.004863|\n", + " 2100| 0.166214 0.266637 0.263656 0.260847 0.011133| 1.652859 1.688172 1.655030 1.656683 0.005230|\n", + " 2200| 0.166214 0.266637 0.263656 0.260501 0.011411| 1.652859 1.688172 1.655030 1.656932 0.005547|\n", + " 2300| 0.166214 0.266637 0.263788 0.260662 0.011773| 1.652859 1.688172 1.654934 1.656813 0.005917|\n", + " 2400| 0.166214 0.266637 0.263788 0.259894 0.012303| 1.652859 1.688172 1.654934 1.657365 0.006482|\n", + " 2500| 0.166214 0.266637 0.263788 0.259444 0.012329| 1.652859 1.688172 1.654934 1.657691 0.006527|\n", + " 2600| 0.166214 0.266637 0.262786 0.258491 0.012477| 1.652859 1.688172 1.655662 1.658380 0.006709|\n", + " 2700| 0.166214 0.266637 0.261982 0.257523 0.012590| 1.652859 1.688172 1.656247 1.659079 0.006854|\n", + " 2800| 0.166214 0.266637 0.261982 0.257289 0.012703| 1.652859 1.688172 1.656247 1.659247 0.006969|\n", + " 2900| 0.166214 0.266637 0.260873 0.256565 0.012312| 1.652859 1.688172 1.657052 1.659774 0.006624|\n", + " 3000| 0.166214 0.266637 0.259745 0.257269 0.011427| 1.652859 1.688172 1.657870 1.659272 0.005721|\n", + " 3100| 0.166214 0.266637 0.258360 0.256199 0.011850| 1.652859 1.688172 1.658873 1.660042 0.006192|\n", + " 3200| 0.166214 0.266637 0.258162 0.255756 0.011817| 1.652859 2.975636 1.659016 1.673584 0.131005|\n", + " 3300| 0.166214 0.266637 0.258459 0.256148 0.012378| 1.652859 2.975636 1.659470 1.739404 0.312396|\n", + " 3400| 0.166214 0.266637 0.261676 0.257592 0.012541| 1.652859 2.975636 1.661068 1.909933 0.515393|\n", + " 3500| 0.166214 0.266637 0.265801 0.260527 0.012466| 1.652859 2.975636 1.681848 2.304150 0.656976|\n", + " 3600| 0.048147 0.268048 0.265801 0.263699 0.021666| 1.652859 3.639538 2.975636 2.965322 0.148680|\n", + " 3700| 0.048147 0.268048 0.265801 0.257289 0.042694| 1.652859 3.639538 2.975636 2.978337 0.190058|\n", + " 3800| 0.048147 0.268048 0.265801 0.250902 0.055630| 1.652859 3.639538 2.975636 2.989388 0.224350|\n", + " 3900| 0.048147 0.268048 0.266421 0.236147 0.075857| 1.652859 3.639538 2.944356 2.995012 0.318456|\n", + " 4000| 0.048147 0.268048 0.266219 0.194576 0.102766| 2.832472 3.639538 2.954783 3.161330 0.337180|\n", + " 4100| 0.024121 0.268048 0.266421 0.172516 0.108533| 2.832472 3.646674 2.944356 3.231834 0.354786|\n", + " 4200| 0.024121 0.268048 0.266421 0.181015 0.107276| 2.832472 3.646674 2.944356 3.203576 0.349486|\n", + " 4300| 0.024121 0.268048 0.266421 0.187310 0.105949| 2.832472 3.646674 2.944356 3.183433 0.343215|\n", + " 4400| 0.024121 0.268048 0.266421 0.196044 0.103078| 2.832472 3.646674 2.944356 3.155358 0.333396|\n", + " 4500| 0.024121 0.268048 0.266280 0.182984 0.107122| 2.832472 3.646674 2.951807 3.194849 0.349360|\n", + " 4600| 0.105311 0.268048 0.267136 0.265213 0.016078| 2.832472 7.960626 2.902648 2.970103 0.502413|\n", + " 4700| 0.105311 0.268048 0.266683 0.263589 0.022617| 2.832472 7.960626 2.929948 3.020956 0.706284|\n", + " 4800| 0.105311 0.268048 0.266683 0.261912 0.027547| 2.832472 7.960626 2.929948 3.074450 0.859947|\n", + " 4900| 0.105311 0.268048 0.266683 0.260233 0.031631| 2.832472 7.960626 2.929948 3.128158 0.987076|\n", + " 5000| 0.105311 0.268048 0.266683 0.258560 0.035166| 2.832472 7.960626 2.929948 3.181409 1.097112|\n" ] }, { "data": { "text/plain": [ - "[[0.9181564151188526, 8.533954360914194];{'b3956': 16, 'b2463': 0},\n", - " [0.8489079919229925, 8.66502935034093];{'b2463': 0, 'b3870': 16, 'b3956': 16},\n", - " [0.7747403052620707, 8.800405071091362];{'b2463': 0, 'b3870': 32, 'b3956': 16},\n", - " [0.9115981881633864, 8.546575594684327];{'b2463': 0, 'b1297': 2, 'b3956': 16},\n", - " [0.7189300114819218, 8.75890236373083];{'b3403': 0, 'b3956': 16, 'b3870': 32, 'b2914': 2},\n", - " [0.9150663940283817, 8.403135775377892];{'b3956': 16, 'b2914': 2},\n", - " [0.836701413447523, 8.549470033946575];{'b2914': 2, 'b3870': 16, 'b3956': 16},\n", - " [0.8251965952132045, 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'b1761': 0.25},\n", + " [0.2660654369859636, 2.962736533609505];{'b1297': 8, 'b1761': 0.125, 'b1276': 16},\n", + " [0.265954768381649, 2.968201296465923];{'b1297': 8, 'b1761': 0.0625, 'b1276': 16},\n", + " [0.2660156317007702, 2.965209440872367];{'b1761': 0.0625, 'b1276': 16}]" ] }, "execution_count": 11, @@ -2913,102 +531,106 @@ " \n", " \n", " 0\n", - " {'b3956': 16, 'b2463': 0}\n", + " {'b1761': 0.5, 'b1276': 16}\n", " 2\n", - " 0.918156\n", - " 8.533954\n", + " 0.268048\n", + " 2.832472\n", " \n", " \n", " 1\n", - " {'b2463': 0, 'b3870': 16, 'b3956': 16}\n", - " 3\n", - " 0.848908\n", - " 8.665029\n", + " {'b1136': 0.0625, 'b1276': 16}\n", + " 2\n", + " 0.105311\n", + " 7.960626\n", " \n", " \n", " 2\n", - " {'b2463': 0, 'b3870': 32, 'b3956': 16}\n", + " {'b1761': 0.0625, 'b1297': 16, 'b1276': 16}\n", " 3\n", - " 0.774740\n", - " 8.800405\n", + " 0.263448\n", + " 3.071447\n", " \n", " \n", " 3\n", - " {'b2463': 0, 'b1297': 2, 'b3956': 16}\n", - " 3\n", - " 0.911598\n", - " 8.546576\n", + " {'b1761': 0.03125, 'b1276': 16}\n", + " 2\n", + " 0.265801\n", + " 2.975636\n", " \n", " \n", " 4\n", - " {'b3403': 0, 'b3956': 16, 'b3870': 32, 'b2914': 2}\n", - " 4\n", - " 0.718930\n", - " 8.758902\n", + " {'b1761': 0.5, 'b1297': 4, 'b1276': 16}\n", + " 3\n", + " 0.267494\n", + " 2.878325\n", " \n", " \n", " 5\n", - " {'b3956': 16, 'b2914': 2}\n", + " {'b1761': 0.25, 'b1276': 16}\n", " 2\n", - " 0.915066\n", - " 8.403136\n", + " 0.267136\n", + " 2.902648\n", " \n", " \n", " 6\n", - " {'b2914': 2, 'b3870': 16, 'b3956': 16}\n", + " {'b1761': 0.5, 'b1297': 8, 'b1276': 16}\n", " 3\n", - " 0.836701\n", - " 8.549470\n", + " 0.266683\n", + " 2.929948\n", " \n", " \n", " 7\n", - " {'b2914': 2, 'b2463': 0, 'b3870': 16, 'b3956': 16}\n", - " 4\n", - " 0.825197\n", - " 8.570459\n", + " {'b1761': 0.125, 'b1276': 16}\n", + " 2\n", + " 0.266421\n", + " 2.944356\n", " \n", " \n", " 8\n", - " {'b2914': 2, 'b3956': 16, 'b3870': 32}\n", + " {'b1297': 8, 'b1276': 16, 'b1761': 0.25}\n", " 3\n", - " 0.752342\n", - " 8.700666\n", + " 0.266280\n", + " 2.951807\n", " \n", " \n", " 9\n", - " {'b3870': 32, 'b2463': 0, 'b2914': 2, 'b3956': 16}\n", - " 4\n", - " 0.751043\n", - " 8.702947\n", + " {'b1297': 8, 'b1761': 0.125, 'b1276': 16}\n", + " 3\n", + " 0.266065\n", + " 2.962737\n", + " \n", + " \n", + " 10\n", + " {'b1297': 8, 'b1761': 0.0625, 'b1276': 16}\n", + " 3\n", + " 0.265955\n", + " 2.968201\n", + " \n", + " \n", + " 11\n", + " {'b1761': 0.0625, 'b1276': 16}\n", + " 2\n", + " 0.266016\n", + " 2.965209\n", " \n", " \n", "\n", "" ], "text/plain": [ - " Modification Size BPCY \\\n", - "0 {'b3956': 16, 'b2463': 0} 2 0.918156 \n", - "1 {'b2463': 0, 'b3870': 16, 'b3956': 16} 3 0.848908 \n", - "2 {'b2463': 0, 'b3870': 32, 'b3956': 16} 3 0.774740 \n", - "3 {'b2463': 0, 'b1297': 2, 'b3956': 16} 3 0.911598 \n", - "4 {'b3403': 0, 'b3956': 16, 'b3870': 32, 'b2914': 2} 4 0.718930 \n", - "5 {'b3956': 16, 'b2914': 2} 2 0.915066 \n", - "6 {'b2914': 2, 'b3870': 16, 'b3956': 16} 3 0.836701 \n", - "7 {'b2914': 2, 'b2463': 0, 'b3870': 16, 'b3956': 16} 4 0.825197 \n", - "8 {'b2914': 2, 'b3956': 16, 'b3870': 32} 3 0.752342 \n", - "9 {'b3870': 32, 'b2463': 0, 'b2914': 2, 'b3956': 16} 4 0.751043 \n", - "\n", - " TargetFlux \n", - "0 8.533954 \n", - "1 8.665029 \n", - "2 8.800405 \n", - "3 8.546576 \n", - "4 8.758902 \n", - "5 8.403136 \n", - "6 8.549470 \n", - "7 8.570459 \n", - "8 8.700666 \n", - "9 8.702947 " + " Modification Size BPCY TargetFlux\n", + "0 {'b1761': 0.5, 'b1276': 16} 2 0.268048 2.832472\n", + "1 {'b1136': 0.0625, 'b1276': 16} 2 0.105311 7.960626\n", + "2 {'b1761': 0.0625, 'b1297': 16, 'b1276': 16} 3 0.263448 3.071447\n", + "3 {'b1761': 0.03125, 'b1276': 16} 2 0.265801 2.975636\n", + "4 {'b1761': 0.5, 'b1297': 4, 'b1276': 16} 3 0.267494 2.878325\n", + "5 {'b1761': 0.25, 'b1276': 16} 2 0.267136 2.902648\n", + "6 {'b1761': 0.5, 'b1297': 8, 'b1276': 16} 3 0.266683 2.929948\n", + "7 {'b1761': 0.125, 'b1276': 16} 2 0.266421 2.944356\n", + "8 {'b1297': 8, 'b1276': 16, 'b1761': 0.25} 3 0.266280 2.951807\n", + "9 {'b1297': 8, 'b1761': 0.125, 'b1276': 16} 3 0.266065 2.962737\n", + "10 {'b1297': 8, 'b1761': 0.0625, 'b1276': 16} 3 0.265955 2.968201\n", + "11 {'b1761': 0.0625, 'b1276': 16} 2 0.266016 2.965209" ] }, "execution_count": 12, @@ -3036,16 +658,18 @@ { "data": { "text/plain": [ - "[[0.9181564151188526, 8.533954360914194];{'b3956': 16, 'b2463': 0},\n", - " [0.8489079919229925, 8.66502935034093];{'b2463': 0, 'b3870': 16, 'b3956': 16},\n", - " [0.7747403052620707, 8.800405071091362];{'b2463': 0, 'b3870': 32, 'b3956': 16},\n", - " [0.9115981881633864, 8.546575594684327];{'b2463': 0, 'b1297': 2, 'b3956': 16},\n", - " [0.7189300114819218, 8.75890236373083];{'b3403': 0, 'b3956': 16, 'b3870': 32, 'b2914': 2},\n", - " [0.9150663940283817, 8.403135775377892];{'b3956': 16, 'b2914': 2},\n", - " [0.836701413447523, 8.549470033946575];{'b2914': 2, 'b3870': 16, 'b3956': 16},\n", - " [0.8251965952132045, 8.570459156801915];{'b2914': 2, 'b2463': 0, 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"text/plain": [ + "[0.10531059695351266, 7.960625859949961];{'b1136': 0.0625, 'b1276': 16}" + ] + }, + "execution_count": 16, + "metadata": {}, + "output_type": "execute_result" } ], "source": [ - "solution = solutions[1]\n", + "solution = ea.final_population[1]\n", "solution" ] }, @@ -3121,9 +744,22 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 17, "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "{'ACONTa': (3.653810503510826, 10000),\n", + " 'ACONTb': (3.653810503510826, 10000),\n", + " 'ICDHyr': (0, 0.014272697279339164)}" + ] + }, + "execution_count": 17, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "solution.constraints" ] @@ -3137,9 +773,22 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 18, "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "objective: 0.0\n", + "Status: OPTIMAL\n", + "Method:ROOM" + ] + }, + "execution_count": 18, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "sim = problem.simulator\n", "res=sim.simulate(constraints=solution.constraints,method='ROOM')\n", @@ -3148,65 +797,240 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 19, "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
ACALD-6.612803
ACALDt-0.001000
ACKr-0.001000
ACONTa3.653811
ACONTb3.653811
......
TALA-0.002290
THD20.219020
TKT1-0.002290
TKT2-0.006911
TPI9.180765
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" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "ACALD -6.612803\n", + "ACALDt -0.001000\n", + "ACKr -0.001000\n", + "ACONTa 3.653811\n", + "ACONTb 3.653811\n", + "... ...\n", + "TALA -0.002290\n", + "THD2 0.219020\n", + "TKT1 -0.002290\n", + "TKT2 -0.006911\n", + "TPI 9.180765\n", + "\n", + "[72 rows x 1 columns]" + ] + }, + "execution_count": 19, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "res.dataframe" ] }, { "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "res.find([PRODUCT,BIOMASS])" - ] - }, - { - "cell_type": "code", - "execution_count": null, - "metadata": {}, - "outputs": [], - "source": [ - "from mewpy.visualization.envelope import plot_flux_envelope\n", - "\n", - "plot_flux_envelope(sim,BIOMASS,PRODUCT,constraints = solution.constraints)" - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "## Exercice 1\n", - "\n", - "Alter the notebook to run a gene over/under-expression (GOUProblem) optimization task. You may also try other optimization objectives (replacing or adding new objectives) such as `CandidateSize`, `ModificationType` or `BPCY_FVA`." - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "## Exercice 2\n", - "\n", - "Alter the notebook to find possible genetic modifications for the increased production of ethanol (EX_etoh_e)" - ] - }, - { - "cell_type": "markdown", - "metadata": {}, - "source": [ - "# Simulating user defined modifications\n", - "\n", - "Genetic modifications at the gene, enzyme, transcription or regulatory levels need to be translated to the (pseudo) reaction level. This task is problem dependent and consequently requires the instantiation of a problem. If we do not intend run any optimization task, there is no need to define optimization objectives." - ] - }, - { - "cell_type": "code", - "execution_count": null, + "execution_count": 20, "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM0.012801
EX_succ_e7.937179
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM 0.012801\n", + "EX_succ_e 7.937179" + ] + }, + "execution_count": 20, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "res.find([PRODUCT,BIOMASS])" + ] + }, + { + "cell_type": "code", + "execution_count": 21, + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "" + ] + }, + "execution_count": 21, + "metadata": {}, + "output_type": "execute_result" + }, + { + "data": { + "image/png": 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\n", + "text/plain": [ + "
" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "from mewpy.visualization.envelope import plot_flux_envelope\n", + "\n", + "plot_flux_envelope(sim,BIOMASS,PRODUCT,constraints = solution.constraints)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Exercice 1\n", + "\n", + "Alter the notebook to run a gene over/under-expression (GOUProblem) optimization task. You may also try other optimization objectives (replacing or adding new objectives) such as `CandidateSize`, `ModificationType` or `BPCY_FVA`." + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "## Exercice 2\n", + "\n", + "Alter the notebook to find possible genetic modifications for the increased production of ethanol (EX_etoh_e)" + ] + }, + { + "cell_type": "markdown", + "metadata": {}, + "source": [ + "# Simulating user defined modifications\n", + "\n", + "Genetic modifications at the gene, enzyme, transcription or regulatory levels need to be translated to the (pseudo) reaction level. This task is problem dependent and consequently requires the instantiation of a problem. If we do not intend run any optimization task, there is no need to define optimization objectives." + ] + }, + { + "cell_type": "code", + "execution_count": 22, + "metadata": {}, + "outputs": [], "source": [ "problem = GOUProblem(model,[], envcond=anaerobic)\n", "sim = problem.simulator" @@ -3221,7 +1045,7 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 23, "metadata": {}, "outputs": [], "source": [ @@ -3237,9 +1061,66 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 24, "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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namereactions
id
b3956[PPC]
b2914[RPI]
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" + ], + "text/plain": [ + " name reactions\n", + "id \n", + "b3956 [PPC]\n", + "b2914 [RPI]" + ] + }, + "execution_count": 24, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "sim.find_genes('b3956|b2914')" ] @@ -3253,9 +1134,20 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 25, "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/plain": [ + "{'PPC': (4.852330790092048, 10000), 'RPI': (-10000, -0.608573313078965)}" + ] + }, + "execution_count": 25, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "constraints = problem.solution_to_constraints(solution)\n", "constraints" @@ -3270,9 +1162,332 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 26, "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
ACALD-5.553093
ACKr-7.150130
ACONTa0.170545
ACONTb0.170545
ACt2r-7.150130
ALCD2x-5.553093
ATPM8.390000
ATPS4r-2.916386
BIOMASS_Ecoli_core_w_GAM0.158073
CO2t3.196934
CS0.170545
ENO18.848367
ETOHt2r-5.553093
EX_ac_e7.150130
EX_co2_e-3.196934
EX_etoh_e5.553093
EX_for_e13.466192
EX_glc__D_e-10.000000
EX_h_e32.585978
EX_h2o_e-3.199204
EX_nh4_e-0.861940
EX_pi_e-0.581503
EX_succ_e4.399357
FBA9.347814
FORt-13.466192
FRD74.399357
FUM-4.399357
G6PDH2r1.484852
GAPD19.084844
GLCpts10.000000
GLNS0.040419
GLUDy-0.821520
GND1.484852
H2Ot3.199204
ICDHyr0.170545
MDH-4.399357
NADH164.399357
NADTRHD0.259371
NH4t0.861940
PFK9.347814
PFL13.466192
PGI8.482743
PGK-19.084844
PGL1.484852
PGM-18.848367
PIt2r0.581503
PPC4.852331
PTAr7.150130
PYK3.913981
RPE0.876278
RPI-0.608573
SUCCt34.399357
TALA0.466671
TKT10.466671
TKT20.409607
TPI9.347814
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "ACALD -5.553093\n", + "ACKr -7.150130\n", + "ACONTa 0.170545\n", + "ACONTb 0.170545\n", + "ACt2r -7.150130\n", + "ALCD2x -5.553093\n", + "ATPM 8.390000\n", + "ATPS4r -2.916386\n", + "BIOMASS_Ecoli_core_w_GAM 0.158073\n", + "CO2t 3.196934\n", + "CS 0.170545\n", + "ENO 18.848367\n", + "ETOHt2r -5.553093\n", + "EX_ac_e 7.150130\n", + "EX_co2_e -3.196934\n", + "EX_etoh_e 5.553093\n", + "EX_for_e 13.466192\n", + "EX_glc__D_e -10.000000\n", + "EX_h_e 32.585978\n", + "EX_h2o_e -3.199204\n", + "EX_nh4_e -0.861940\n", + "EX_pi_e -0.581503\n", + "EX_succ_e 4.399357\n", + "FBA 9.347814\n", + "FORt -13.466192\n", + "FRD7 4.399357\n", + "FUM -4.399357\n", + "G6PDH2r 1.484852\n", + "GAPD 19.084844\n", + "GLCpts 10.000000\n", + "GLNS 0.040419\n", + "GLUDy -0.821520\n", + "GND 1.484852\n", + "H2Ot 3.199204\n", + "ICDHyr 0.170545\n", + "MDH -4.399357\n", + "NADH16 4.399357\n", + "NADTRHD 0.259371\n", + "NH4t 0.861940\n", + "PFK 9.347814\n", + "PFL 13.466192\n", + "PGI 8.482743\n", + "PGK -19.084844\n", + "PGL 1.484852\n", + "PGM -18.848367\n", + "PIt2r 0.581503\n", + "PPC 4.852331\n", + "PTAr 7.150130\n", + "PYK 3.913981\n", + "RPE 0.876278\n", + "RPI -0.608573\n", + "SUCCt3 4.399357\n", + "TALA 0.466671\n", + "TKT1 0.466671\n", + "TKT2 0.409607\n", + "TPI 9.347814" + ] + }, + "execution_count": 26, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "sim.simulate(constraints=constraints).find()" ] @@ -3287,18 +1502,122 @@ }, { "cell_type": "code", - "execution_count": null, + "execution_count": 27, "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM0.158073
EX_succ_e4.399357
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" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM 0.158073\n", + "EX_succ_e 4.399357" + ] + }, + "execution_count": 27, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "problem.simulate(solution=solution,method='pFBA').find(['succ','BIOMASS'])" ] }, { "cell_type": "code", - "execution_count": null, + "execution_count": 28, "metadata": {}, - "outputs": [], + "outputs": [ + { + "data": { + "text/html": [ + "
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MinimumMaximum
Reaction ID
EX_succ_e0.05.649814
\n", + "
" + ], + "text/plain": [ + " Minimum Maximum\n", + "Reaction ID \n", + "EX_succ_e 0.0 5.649814" + ] + }, + "execution_count": 28, + "metadata": {}, + "output_type": "execute_result" + } + ], "source": [ "problem.FVA('EX_succ_e', solution=solution, format='df')" ] diff --git a/examples/04-ROUproblem.ipynb b/examples/04-ROUproblem.ipynb index 47236f4f..148e650c 100644 --- a/examples/04-ROUproblem.ipynb +++ b/examples/04-ROUproblem.ipynb @@ -77,9 +77,7 @@ { "cell_type": "code", "execution_count": 2, - "metadata": { - "scrolled": false - }, + "metadata": {}, "outputs": [ { "name": "stdout", @@ -2380,9 +2378,9 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.7.13" + "version": "3.9.15" } }, "nbformat": 4, - "nbformat_minor": 2 + "nbformat_minor": 4 } diff --git a/examples/05-GOUproblem.ipynb b/examples/05-GOUproblem.ipynb index 3457ecdc..e389ab7f 100644 --- a/examples/05-GOUproblem.ipynb +++ b/examples/05-GOUproblem.ipynb @@ -557,7 +557,7 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.7.13" + "version": "3.9.15" }, "vscode": { "interpreter": { @@ -566,5 +566,5 @@ } }, "nbformat": 4, - "nbformat_minor": 2 + "nbformat_minor": 4 } diff --git a/examples/06-GeckoKOProblem.ipynb b/examples/06-GeckoKOProblem.ipynb index 9672e022..713441e7 100644 --- a/examples/06-GeckoKOProblem.ipynb +++ b/examples/06-GeckoKOProblem.ipynb @@ -973,9 +973,9 @@ ], "metadata": { "kernelspec": { - "display_name": "py37", + "display_name": "cobra", "language": "python", - "name": "py37" + "name": "cobra" }, "language_info": { "codemirror_mode": { @@ -987,9 +987,9 @@ "name": "python", "nbconvert_exporter": "python", "pygments_lexer": "ipython3", - "version": "3.7.13" + "version": "3.9.15" } }, "nbformat": 4, - "nbformat_minor": 2 + "nbformat_minor": 4 } diff --git a/examples/08-community.ipynb b/examples/08-community.ipynb index aa4f4827..f6da42d8 100644 --- a/examples/08-community.ipynb +++ b/examples/08-community.ipynb @@ -33,17 +33,7 @@ "execution_count": 1, "id": "5af506f8", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "\u001b[31mERROR: Could not find a version that satisfies the requirement cplex (from versions: none)\u001b[0m\u001b[31m\r\n", - "\u001b[0m\u001b[31mERROR: No matching distribution found for cplex\u001b[0m\u001b[31m\r\n", - "\u001b[0m" - ] - } - ], + "outputs": [], "source": [ "! pip install -U -q mewpy cplex escher" ] @@ -70,8 +60,8 @@ "Author: Vitor Pereira and CEB University of Minho (2019-2023)\n", "Contact: vpereira@ceb.uminho.pt \n", "\n", - "Available LP solvers: gurobi glpk\n", - "Default LP solver: gurobi \n", + "Available LP solvers: gurobi cplex glpk\n", + "Default LP solver: cplex \n", "\n", "Available ODE solvers: scikits scipy\n", "Default ODE solver: scikits \n", @@ -271,17 +261,7 @@ "execution_count": 6, "id": "196680b4", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5umex3nd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - } - ], + "outputs": [], "source": [ "glc_ko = wildtype.copy()\n", "glc_ko.id = 'glc_ko'\n", @@ -293,17 +273,7 @@ "execution_count": 7, "id": "baeb1a1d", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppa7oqn08.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - } - ], + "outputs": [], "source": [ "nh4_ko = wildtype.copy()\n", "nh4_ko.id = 'nh4_ko'\n", @@ -325,38 +295,7 @@ "execution_count": 8, "id": "b6e5ff2a", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1wo73ab7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwwu46zy5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf4ganvfa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoceccu6a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuswj5kch.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2u8c1ksl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphhe8sm34.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl05tnob9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - } - ], + "outputs": [], "source": [ "from mewpy.com import *\n", "mets, rxns, over = jaccard_similarity_matrices([glc_ko, nh4_ko])" @@ -557,31 +496,18 @@ }, { "cell_type": "code", - "execution_count": 12, + "execution_count": 46, "id": "91e413e9", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp60mi7930.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdawhibpd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - } - ], + "outputs": [], "source": [ "from mewpy.model import CommunityModel\n", - "community = CommunityModel([glc_ko, nh4_ko], flavor='cobra')" + "community = CommunityModel([glc_ko, nh4_ko], merge_biomasses=False, flavor='cobra')" ] }, { "cell_type": "code", - "execution_count": 13, + "execution_count": 47, "id": "46ed57b9", "metadata": {}, "outputs": [ @@ -589,7 +515,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.25it/s]\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.32it/s]\n" ] } ], @@ -609,19 +535,10 @@ }, { "cell_type": "code", - "execution_count": 14, + "execution_count": 48, "id": "6644486c", "metadata": {}, "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbh5i37l9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, { "data": { "text/html": [ @@ -760,7 +677,7 @@ "EX_succ_e\t0.0\t1000.0" ] }, - "execution_count": 14, + "execution_count": 48, "metadata": {}, "output_type": "execute_result" } @@ -783,7 +700,7 @@ }, { "cell_type": "code", - "execution_count": 15, + "execution_count": 49, "id": "47cb7a4b", "metadata": {}, "outputs": [ @@ -791,7 +708,7 @@ "name": "stdout", "output_type": "stream", "text": [ - "objective: 0.40757209363986224\n", + "objective: 0.831195550185812\n", "Status: OPTIMAL\n", "Method:FBA\n" ] @@ -826,120 +743,108 @@ " \n", " \n", " \n", - " EX_glc__D_e\n", - " -10.000000\n", - " \n", - " \n", - " EX_h2o_e\n", - " 31.248968\n", + " EX_ac_e_glc_ko\n", + " -6.134506\n", " \n", " \n", - " EX_h_e\n", - " 16.351792\n", + " EX_akg_e_glc_ko\n", + " -4.532343\n", " \n", " \n", - " EX_nh4_e\n", - " -4.444818\n", + " EX_co2_e_glc_ko\n", + " 9.064686\n", " \n", " \n", - " EX_o2_e\n", - " -24.368743\n", + " EX_etoh_e_glc_ko\n", + " 1.602163\n", " \n", " \n", - " EX_pi_e\n", - " -2.998671\n", + " EX_glu__L_e_glc_ko\n", + " 4.532343\n", " \n", " \n", - " EX_co2_e\n", - " 25.311132\n", + " EX_h_e_glc_ko\n", + " -6.134506\n", " \n", " \n", - " EX_glc__D_e_nh4_ko\n", - " -10.000000\n", + " EX_h2o_e_glc_ko\n", + " 7.462523\n", " \n", " \n", - " EX_glu__L_e_glc_ko\n", - " 2.222409\n", + " EX_nh4_e_glc_ko\n", + " -4.532343\n", " \n", " \n", - " EX_glu__L_e_nh4_ko\n", - " -2.222409\n", + " EX_o2_e_glc_ko\n", + " -5.196352\n", " \n", " \n", - " EX_h2o_e_glc_ko\n", - " 30.945021\n", + " EX_ac_e_nh4_ko\n", + " 6.134506\n", " \n", " \n", - " EX_h2o_e_nh4_ko\n", - " 0.303946\n", + " EX_akg_e_nh4_ko\n", + " 4.532343\n", " \n", " \n", - " EX_h_e_glc_ko\n", - " -5.029965\n", + " EX_co2_e_nh4_ko\n", + " 15.563372\n", " \n", " \n", - " EX_h_e_nh4_ko\n", - " 21.381758\n", + " EX_etoh_e_nh4_ko\n", + " -1.602163\n", " \n", " \n", - " EX_lac__D_e_glc_ko\n", - " -20.076753\n", + " EX_glc__D_e_nh4_ko\n", + " -10.000000\n", " \n", " \n", - " EX_lac__D_e_nh4_ko\n", - " 20.076753\n", + " EX_glu__L_e_nh4_ko\n", + " -4.532343\n", " \n", " \n", - " EX_nh4_e_glc_ko\n", - " -4.444818\n", + " EX_h_e_nh4_ko\n", + " 22.808289\n", " \n", " \n", - " EX_o2_e_glc_ko\n", - " -19.052926\n", + " EX_h2o_e_nh4_ko\n", + " 23.220295\n", " \n", " \n", " EX_o2_e_nh4_ko\n", - " -5.315818\n", - " \n", - " \n", - " EX_pi_e_glc_ko\n", - " -1.499335\n", + " -18.470761\n", " \n", " \n", " EX_pi_e_nh4_ko\n", - " -1.499335\n", + " -3.057719\n", " \n", " \n", - " EX_pyr_e_glc_ko\n", - " 17.017435\n", - " \n", - " \n", - " EX_pyr_e_nh4_ko\n", - " -17.017435\n", + " EX_glc__D_e\n", + " -10.000000\n", " \n", " \n", - " EX_ac_e_glc_ko\n", - " -7.810667\n", + " EX_h2o_e\n", + " 30.682819\n", " \n", " \n", - " EX_ac_e_nh4_ko\n", - " 7.810667\n", + " EX_h_e\n", + " 16.673783\n", " \n", " \n", - " EX_akg_e_glc_ko\n", - " -3.390348\n", + " EX_nh4_e\n", + " -4.532343\n", " \n", " \n", - " EX_akg_e_nh4_ko\n", - " 3.390348\n", + " EX_o2_e\n", + " -23.667113\n", " \n", " \n", - " EX_co2_e_glc_ko\n", - " 13.294545\n", + " EX_pi_e\n", + " -3.057719\n", " \n", " \n", - " EX_co2_e_nh4_ko\n", - " 12.016587\n", + " EX_co2_e\n", + " 24.628058\n", " \n", " \n", "\n", @@ -948,38 +853,35 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "EX_glc__D_e -10.000000\n", - "EX_h2o_e 31.248968\n", - "EX_h_e 16.351792\n", - "EX_nh4_e -4.444818\n", - "EX_o2_e -24.368743\n", - "EX_pi_e -2.998671\n", - "EX_co2_e 25.311132\n", + "EX_ac_e_glc_ko -6.134506\n", + "EX_akg_e_glc_ko -4.532343\n", + "EX_co2_e_glc_ko 9.064686\n", + "EX_etoh_e_glc_ko 1.602163\n", + "EX_glu__L_e_glc_ko 4.532343\n", + "EX_h_e_glc_ko -6.134506\n", + "EX_h2o_e_glc_ko 7.462523\n", + "EX_nh4_e_glc_ko -4.532343\n", + "EX_o2_e_glc_ko -5.196352\n", + "EX_ac_e_nh4_ko 6.134506\n", + "EX_akg_e_nh4_ko 4.532343\n", + "EX_co2_e_nh4_ko 15.563372\n", + "EX_etoh_e_nh4_ko -1.602163\n", "EX_glc__D_e_nh4_ko -10.000000\n", - "EX_glu__L_e_glc_ko 2.222409\n", - "EX_glu__L_e_nh4_ko -2.222409\n", - "EX_h2o_e_glc_ko 30.945021\n", - "EX_h2o_e_nh4_ko 0.303946\n", - "EX_h_e_glc_ko -5.029965\n", - "EX_h_e_nh4_ko 21.381758\n", - "EX_lac__D_e_glc_ko -20.076753\n", - "EX_lac__D_e_nh4_ko 20.076753\n", - "EX_nh4_e_glc_ko -4.444818\n", - "EX_o2_e_glc_ko -19.052926\n", - "EX_o2_e_nh4_ko -5.315818\n", - "EX_pi_e_glc_ko -1.499335\n", - "EX_pi_e_nh4_ko -1.499335\n", - "EX_pyr_e_glc_ko 17.017435\n", - "EX_pyr_e_nh4_ko -17.017435\n", - "EX_ac_e_glc_ko -7.810667\n", - "EX_ac_e_nh4_ko 7.810667\n", - "EX_akg_e_glc_ko -3.390348\n", - "EX_akg_e_nh4_ko 3.390348\n", - "EX_co2_e_glc_ko 13.294545\n", - "EX_co2_e_nh4_ko 12.016587" + "EX_glu__L_e_nh4_ko -4.532343\n", + "EX_h_e_nh4_ko 22.808289\n", + "EX_h2o_e_nh4_ko 23.220295\n", + "EX_o2_e_nh4_ko -18.470761\n", + "EX_pi_e_nh4_ko -3.057719\n", + "EX_glc__D_e -10.000000\n", + "EX_h2o_e 30.682819\n", + "EX_h_e 16.673783\n", + "EX_nh4_e -4.532343\n", + "EX_o2_e -23.667113\n", + "EX_pi_e -3.057719\n", + "EX_co2_e 24.628058" ] }, - "execution_count": 15, + "execution_count": 49, "metadata": {}, "output_type": "execute_result" } @@ -1005,7 +907,7 @@ }, { "cell_type": "code", - "execution_count": 16, + "execution_count": 50, "id": "0b5d171f", "metadata": {}, "outputs": [ @@ -1040,11 +942,11 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 0.407572\n", + " 0.000000\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 0.407572\n", + " 0.831196\n", " \n", " \n", "\n", @@ -1053,11 +955,11 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.000000\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.831196" ] }, - "execution_count": 16, + "execution_count": 50, "metadata": {}, "output_type": "execute_result" } @@ -1076,7 +978,7 @@ }, { "cell_type": "code", - "execution_count": 17, + "execution_count": 51, "id": "960e9b0b", "metadata": {}, "outputs": [ @@ -1114,6 +1016,12 @@ " \n", " \n", " \n", + " community_biomass\n", + " Total community biomass\n", + " e\n", + " None\n", + " \n", + " \n", " glc__D_e_glc_ko\n", " D-Glucose\n", " e_glc_ko\n", @@ -1138,18 +1046,18 @@ " C5H10N2O3\n", " \n", " \n", - " gln__L_e\n", - " L-Glutamine\n", - " e\n", - " C5H10N2O3\n", - " \n", - " \n", " ...\n", " ...\n", " ...\n", " ...\n", " \n", " \n", + " fru_e_nh4_ko\n", + " D-Fructose\n", + " e_nh4_ko\n", + " C6H12O6\n", + " \n", + " \n", " fum_c_nh4_ko\n", " Fumarate\n", " c_nh4_ko\n", @@ -1173,36 +1081,30 @@ " c_nh4_ko\n", " C6H11O9P\n", " \n", - " \n", - " Biomass_nh4_ko\n", - " Biomass nh4_ko\n", - " e\n", - " None\n", - " \n", " \n", "\n", - "

166 rows × 3 columns

\n", + "

165 rows × 3 columns

\n", "" ], "text/plain": [ - " name compartment formula\n", - "id \n", - "glc__D_e_glc_ko D-Glucose e_glc_ko C6H12O6\n", - "glc__D_e D-Glucose e C6H12O6\n", - "gln__L_c_glc_ko L-Glutamine c_glc_ko C5H10N2O3\n", - "gln__L_e_glc_ko L-Glutamine e_glc_ko C5H10N2O3\n", - "gln__L_e L-Glutamine e C5H10N2O3\n", - "... ... ... ...\n", - "fum_c_nh4_ko Fumarate c_nh4_ko C4H2O4\n", - "fum_e_nh4_ko Fumarate e_nh4_ko C4H2O4\n", - "g3p_c_nh4_ko Glyceraldehyde 3-phosphate c_nh4_ko C3H5O6P\n", - "g6p_c_nh4_ko D-Glucose 6-phosphate c_nh4_ko C6H11O9P\n", - "Biomass_nh4_ko Biomass nh4_ko e None\n", + " name compartment formula\n", + "id \n", + "community_biomass Total community biomass e None\n", + "glc__D_e_glc_ko D-Glucose e_glc_ko C6H12O6\n", + "glc__D_e D-Glucose e C6H12O6\n", + "gln__L_c_glc_ko L-Glutamine c_glc_ko C5H10N2O3\n", + "gln__L_e_glc_ko L-Glutamine e_glc_ko C5H10N2O3\n", + "... ... ... ...\n", + "fru_e_nh4_ko D-Fructose e_nh4_ko C6H12O6\n", + "fum_c_nh4_ko Fumarate c_nh4_ko C4H2O4\n", + "fum_e_nh4_ko Fumarate e_nh4_ko C4H2O4\n", + "g3p_c_nh4_ko Glyceraldehyde 3-phosphate c_nh4_ko C3H5O6P\n", + "g6p_c_nh4_ko D-Glucose 6-phosphate c_nh4_ko C6H11O9P\n", "\n", - "[166 rows x 3 columns]" + "[165 rows x 3 columns]" ] }, - "execution_count": 17, + "execution_count": 51, "metadata": {}, "output_type": "execute_result" } @@ -1213,7 +1115,7 @@ }, { "cell_type": "code", - "execution_count": 18, + "execution_count": 72, "id": "a69cf655", "metadata": {}, "outputs": [ @@ -1247,220 +1149,224 @@ " \n", " \n", " \n", - " ACKr_nh4_ko\n", - " -7.810667\n", + " ACALD_glc_ko\n", + " 7.810667\n", " \n", " \n", - " ACONTa_nh4_ko\n", - " 1.607668\n", + " ACALDt_glc_ko\n", + " 0.288725\n", " \n", " \n", - " ACONTb_nh4_ko\n", - " 1.607668\n", + " ACONTa_glc_ko\n", + " 6.283168\n", " \n", " \n", - " ACt2r_nh4_ko\n", - " -7.810667\n", + " ACONTb_glc_ko\n", + " 6.283168\n", " \n", " \n", - " AKGt2r_nh4_ko\n", - " -3.390348\n", + " ADK1_glc_ko\n", + " 1.904747\n", " \n", " \n", - " ATPM_nh4_ko\n", - " 8.390000\n", + " AKGDH_glc_ko\n", + " 7.011377\n", " \n", " \n", - " ATPS4r_nh4_ko\n", - " 10.578752\n", + " AKGt2r_glc_ko\n", + " 3.390348\n", " \n", " \n", - " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 0.407572\n", + " ALCD2x_glc_ko\n", + " 7.521941\n", " \n", " \n", - " CO2t_nh4_ko\n", - " -12.016587\n", + " ATPM_glc_ko\n", + " 8.390000\n", " \n", " \n", - " CS_nh4_ko\n", - " 1.607668\n", + " ATPS4r_glc_ko\n", + " 30.752670\n", " \n", " \n", - " CYTBD_nh4_ko\n", - " 10.631636\n", + " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", + " 0.407572\n", " \n", " \n", - " D_LACt2_nh4_ko\n", - " -20.076753\n", + " CO2t_glc_ko\n", + " -13.294545\n", " \n", " \n", - " ENO_nh4_ko\n", - " 17.707169\n", + " CS_glc_ko\n", + " 6.283168\n", " \n", " \n", - " FBA_nh4_ko\n", - " 8.994934\n", + " CYTBD_glc_ko\n", + " 33.361706\n", " \n", " \n", - " G6PDH2r_nh4_ko\n", - " 1.798962\n", + " ENO_glc_ko\n", + " -1.693177\n", " \n", " \n", - " GAPD_nh4_ko\n", - " 18.316897\n", + " ETOHt2r_glc_ko\n", + " 7.521941\n", " \n", " \n", - " GLCpts_nh4_ko\n", - " 10.000000\n", + " FBA_glc_ko\n", + " -0.405412\n", " \n", " \n", - " GLNS_nh4_ko\n", - " 0.104216\n", + " FBP_glc_ko\n", + " 0.405412\n", " \n", " \n", - " GLUDy_nh4_ko\n", - " 0.104216\n", + " FUM_glc_ko\n", + " 7.011377\n", " \n", " \n", - " GLUt2r_nh4_ko\n", - " 2.222409\n", + " GAPD_glc_ko\n", + " -1.083449\n", " \n", " \n", - " GND_nh4_ko\n", - " 1.798962\n", + " GLNS_glc_ko\n", + " 0.104216\n", " \n", " \n", - " H2Ot_nh4_ko\n", - " -0.303946\n", + " GLUDy_glc_ko\n", + " -4.340602\n", " \n", " \n", - " ICDHyr_nh4_ko\n", - " 1.607668\n", + " GLUt2r_glc_ko\n", + " -2.222409\n", " \n", " \n", - " LDH_D_nh4_ko\n", - " -20.076753\n", + " H2Ot_glc_ko\n", + " -18.390210\n", " \n", " \n", - " NADH16_nh4_ko\n", - " 10.631636\n", + " ICDHyr_glc_ko\n", + " 6.283168\n", " \n", " \n", - " O2t_nh4_ko\n", - " 5.315818\n", + " MDH_glc_ko\n", + " 7.011377\n", " \n", " \n", - " PDH_nh4_ko\n", - " 10.945833\n", + " NADH16_glc_ko\n", + " 26.350329\n", " \n", " \n", - " PFK_nh4_ko\n", - " 8.994934\n", + " NH4t_glc_ko\n", + " 4.444818\n", " \n", " \n", - " PGI_nh4_ko\n", - " 8.117486\n", + " O2t_glc_ko\n", + " 16.680853\n", " \n", " \n", - " PGK_nh4_ko\n", - " -18.316897\n", + " PGI_glc_ko\n", + " -0.083552\n", " \n", " \n", - " PGL_nh4_ko\n", - " 1.798962\n", + " PGK_glc_ko\n", + " 1.083449\n", " \n", " \n", - " PGM_nh4_ko\n", - " -17.707169\n", + " PGM_glc_ko\n", + " 1.693177\n", " \n", " \n", - " PIt2r_nh4_ko\n", + " PIt2r_glc_ko\n", " 1.499335\n", " \n", " \n", - " PPC_nh4_ko\n", - " 2.335877\n", + " PPS_glc_ko\n", + " 1.904747\n", " \n", " \n", - " PTAr_nh4_ko\n", - " 7.810667\n", + " PYRt2_glc_ko\n", + " 3.059318\n", " \n", " \n", - " PYK_nh4_ko\n", - " 5.159721\n", + " RPE_glc_ko\n", + " -0.292963\n", " \n", " \n", - " PYRt2_nh4_ko\n", - " 17.017435\n", + " RPI_glc_ko\n", + " -0.292963\n", " \n", " \n", - " RPE_nh4_ko\n", - " 0.906345\n", + " SUCDi_glc_ko\n", + " 7.011377\n", " \n", " \n", - " RPI_nh4_ko\n", - " -0.892617\n", + " SUCOAS_glc_ko\n", + " -7.011377\n", " \n", " \n", - " TALA_nh4_ko\n", - " 0.526739\n", + " TALA_glc_ko\n", + " -0.072915\n", " \n", " \n", - " TKT1_nh4_ko\n", - " 0.526739\n", + " THD2_glc_ko\n", + " 3.367243\n", " \n", " \n", - " TKT2_nh4_ko\n", - " 0.379606\n", + " TKT1_glc_ko\n", + " -0.072915\n", " \n", " \n", - " TPI_nh4_ko\n", - " 8.994934\n", + " TKT2_glc_ko\n", + " -0.220048\n", " \n", " \n", - " EX_glc__D_e_nh4_ko\n", - " -10.000000\n", + " TPI_glc_ko\n", + " -0.405412\n", " \n", " \n", - " EX_glu__L_e_nh4_ko\n", - " -2.222409\n", + " EX_glu__L_e_glc_ko\n", + " 2.222409\n", " \n", " \n", - " EX_h2o_e_nh4_ko\n", - " 0.303946\n", + " EX_h2o_e_glc_ko\n", + " 18.390210\n", " \n", " \n", - " EX_h_e_nh4_ko\n", - " 21.381758\n", + " EX_h_e_glc_ko\n", + " 2.780701\n", " \n", " \n", - " EX_lac__D_e_nh4_ko\n", - " 20.076753\n", + " EX_nh4_e_glc_ko\n", + " -4.444818\n", " \n", " \n", - " EX_o2_e_nh4_ko\n", - " -5.315818\n", + " EX_o2_e_glc_ko\n", + " -16.680853\n", " \n", " \n", - " EX_pi_e_nh4_ko\n", + " EX_pi_e_glc_ko\n", " -1.499335\n", " \n", " \n", - " EX_pyr_e_nh4_ko\n", - " -17.017435\n", + " EX_pyr_e_glc_ko\n", + " -3.059318\n", " \n", " \n", - " EX_ac_e_nh4_ko\n", - " 7.810667\n", + " EX_acald_e_glc_ko\n", + " -0.288725\n", " \n", " \n", - " EX_akg_e_nh4_ko\n", - " 3.390348\n", + " EX_akg_e_glc_ko\n", + " -3.390348\n", " \n", " \n", - " EX_co2_e_nh4_ko\n", - " 12.016587\n", + " EX_co2_e_glc_ko\n", + " 13.294545\n", + " \n", + " \n", + " EX_etoh_e_glc_ko\n", + " -7.521941\n", " \n", " \n", "\n", @@ -1469,69 +1375,70 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "ACKr_nh4_ko -7.810667\n", - "ACONTa_nh4_ko 1.607668\n", - "ACONTb_nh4_ko 1.607668\n", - "ACt2r_nh4_ko -7.810667\n", - "AKGt2r_nh4_ko -3.390348\n", - "ATPM_nh4_ko 8.390000\n", - "ATPS4r_nh4_ko 10.578752\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", - "CO2t_nh4_ko -12.016587\n", - "CS_nh4_ko 1.607668\n", - "CYTBD_nh4_ko 10.631636\n", - "D_LACt2_nh4_ko -20.076753\n", - "ENO_nh4_ko 17.707169\n", - "FBA_nh4_ko 8.994934\n", - "G6PDH2r_nh4_ko 1.798962\n", - "GAPD_nh4_ko 18.316897\n", - "GLCpts_nh4_ko 10.000000\n", - "GLNS_nh4_ko 0.104216\n", - "GLUDy_nh4_ko 0.104216\n", - "GLUt2r_nh4_ko 2.222409\n", - "GND_nh4_ko 1.798962\n", - "H2Ot_nh4_ko -0.303946\n", - "ICDHyr_nh4_ko 1.607668\n", - "LDH_D_nh4_ko -20.076753\n", - "NADH16_nh4_ko 10.631636\n", - "O2t_nh4_ko 5.315818\n", - "PDH_nh4_ko 10.945833\n", - "PFK_nh4_ko 8.994934\n", - "PGI_nh4_ko 8.117486\n", - "PGK_nh4_ko -18.316897\n", - "PGL_nh4_ko 1.798962\n", - "PGM_nh4_ko -17.707169\n", - "PIt2r_nh4_ko 1.499335\n", - "PPC_nh4_ko 2.335877\n", - "PTAr_nh4_ko 7.810667\n", - "PYK_nh4_ko 5.159721\n", - "PYRt2_nh4_ko 17.017435\n", - "RPE_nh4_ko 0.906345\n", - "RPI_nh4_ko -0.892617\n", - "TALA_nh4_ko 0.526739\n", - "TKT1_nh4_ko 0.526739\n", - "TKT2_nh4_ko 0.379606\n", - "TPI_nh4_ko 8.994934\n", - "EX_glc__D_e_nh4_ko -10.000000\n", - "EX_glu__L_e_nh4_ko -2.222409\n", - "EX_h2o_e_nh4_ko 0.303946\n", - "EX_h_e_nh4_ko 21.381758\n", - "EX_lac__D_e_nh4_ko 20.076753\n", - "EX_o2_e_nh4_ko -5.315818\n", - "EX_pi_e_nh4_ko -1.499335\n", - "EX_pyr_e_nh4_ko -17.017435\n", - "EX_ac_e_nh4_ko 7.810667\n", - "EX_akg_e_nh4_ko 3.390348\n", - "EX_co2_e_nh4_ko 12.016587" + "ACALD_glc_ko 7.810667\n", + "ACALDt_glc_ko 0.288725\n", + "ACONTa_glc_ko 6.283168\n", + "ACONTb_glc_ko 6.283168\n", + "ADK1_glc_ko 1.904747\n", + "AKGDH_glc_ko 7.011377\n", + "AKGt2r_glc_ko 3.390348\n", + "ALCD2x_glc_ko 7.521941\n", + "ATPM_glc_ko 8.390000\n", + "ATPS4r_glc_ko 30.752670\n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", + "CO2t_glc_ko -13.294545\n", + "CS_glc_ko 6.283168\n", + "CYTBD_glc_ko 33.361706\n", + "ENO_glc_ko -1.693177\n", + "ETOHt2r_glc_ko 7.521941\n", + "FBA_glc_ko -0.405412\n", + "FBP_glc_ko 0.405412\n", + "FUM_glc_ko 7.011377\n", + "GAPD_glc_ko -1.083449\n", + "GLNS_glc_ko 0.104216\n", + "GLUDy_glc_ko -4.340602\n", + "GLUt2r_glc_ko -2.222409\n", + "H2Ot_glc_ko -18.390210\n", + "ICDHyr_glc_ko 6.283168\n", + "MDH_glc_ko 7.011377\n", + "NADH16_glc_ko 26.350329\n", + "NH4t_glc_ko 4.444818\n", + "O2t_glc_ko 16.680853\n", + "PGI_glc_ko -0.083552\n", + "PGK_glc_ko 1.083449\n", + "PGM_glc_ko 1.693177\n", + "PIt2r_glc_ko 1.499335\n", + "PPS_glc_ko 1.904747\n", + "PYRt2_glc_ko 3.059318\n", + "RPE_glc_ko -0.292963\n", + "RPI_glc_ko -0.292963\n", + "SUCDi_glc_ko 7.011377\n", + "SUCOAS_glc_ko -7.011377\n", + "TALA_glc_ko -0.072915\n", + "THD2_glc_ko 3.367243\n", + "TKT1_glc_ko -0.072915\n", + "TKT2_glc_ko -0.220048\n", + "TPI_glc_ko -0.405412\n", + "EX_glu__L_e_glc_ko 2.222409\n", + "EX_h2o_e_glc_ko 18.390210\n", + "EX_h_e_glc_ko 2.780701\n", + "EX_nh4_e_glc_ko -4.444818\n", + "EX_o2_e_glc_ko -16.680853\n", + "EX_pi_e_glc_ko -1.499335\n", + "EX_pyr_e_glc_ko -3.059318\n", + "EX_acald_e_glc_ko -0.288725\n", + "EX_akg_e_glc_ko -3.390348\n", + "EX_co2_e_glc_ko 13.294545\n", + "EX_etoh_e_glc_ko -7.521941" ] }, - "execution_count": 18, + "execution_count": 72, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "solution.find('nh4_ko')" + "solution.find('glc_ko')" ] }, { @@ -1558,7 +1465,7 @@ }, { "cell_type": "code", - "execution_count": 19, + "execution_count": 53, "id": "c4727cf5", "metadata": {}, "outputs": [], @@ -1568,18 +1475,10 @@ }, { "cell_type": "code", - "execution_count": 20, + "execution_count": 54, "id": "c80e5339", "metadata": {}, "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, { "data": { "text/html": [ @@ -1611,29 +1510,29 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 0.407572\n", + " 4.545680e-11\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 0.407572\n", + " 8.311956e-01\n", " \n", " \n", " community_growth\n", - " 0.407572\n", + " 8.311956e-01\n", " \n", " \n", "\n", "" ], "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", - "community_growth 0.407572" + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 4.545680e-11\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 8.311956e-01\n", + "community_growth 8.311956e-01" ] }, - "execution_count": 20, + "execution_count": 54, "metadata": {}, "output_type": "execute_result" } @@ -1653,18 +1552,10 @@ }, { "cell_type": "code", - "execution_count": 21, + "execution_count": 55, "id": "e6698a36", "metadata": {}, "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, { "data": { "text/html": [ @@ -1696,29 +1587,29 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 0.407572\n", + " 4.545680e-11\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 0.407572\n", + " 8.311956e-01\n", " \n", " \n", " community_growth\n", - " 0.407572\n", + " 8.311956e-01\n", " \n", " \n", "\n", "" ], "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572\n", - "community_growth 0.407572" + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 4.545680e-11\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 8.311956e-01\n", + "community_growth 8.311956e-01" ] }, - "execution_count": 21, + "execution_count": 55, "metadata": {}, "output_type": "execute_result" } @@ -1748,7 +1639,7 @@ }, { "cell_type": "code", - "execution_count": 22, + "execution_count": 56, "id": "2214667c", "metadata": {}, "outputs": [ @@ -1756,22 +1647,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.47it/s]" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stderr", - "output_type": "stream", - "text": [ - "\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.92it/s]\n" ] } ], @@ -1789,19 +1665,19 @@ }, { "cell_type": "code", - "execution_count": 23, + "execution_count": 57, "id": "50794ba1", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "Community growth: 0.027466848121545602\n", - "glc_ko\t1.0\n", - "nh4_ko\t30.78547721007576" + "Community growth: 0.873046875\n", + "glc_ko\t0.024884385078816997\n", + "nh4_ko\t0.9751156149211829" ] }, - "execution_count": 23, + "execution_count": 57, "metadata": {}, "output_type": "execute_result" } @@ -1820,7 +1696,7 @@ }, { "cell_type": "code", - "execution_count": 24, + "execution_count": 58, "id": "e5b8887e", "metadata": {}, "outputs": [ @@ -1853,67 +1729,67 @@ " \n", " \n", " \n", - " 14\n", - " glc_ko\n", - " nh4_ko\n", - " acald_e\n", - " 31.460909\n", - " \n", - " \n", - " 13\n", + " 12\n", " nh4_ko\n", " glc_ko\n", - " ac_e\n", - " 21.026083\n", + " pyr_e\n", + " 24.884385\n", " \n", " \n", - " 4\n", - " nh4_ko\n", + " 6\n", " glc_ko\n", - " h_e\n", - " 20.838688\n", + " nh4_ko\n", + " lac__D_e\n", + " 24.721311\n", " \n", " \n", " 18\n", " nh4_ko\n", " glc_ko\n", " etoh_e\n", - " 15.584869\n", + " 12.124982\n", " \n", " \n", - " 6\n", - " nh4_ko\n", - " glc_ko\n", - " lac__D_e\n", - " 5.896268\n", - " \n", - " \n", - " 12\n", + " 14\n", " glc_ko\n", " nh4_ko\n", - " pyr_e\n", - " 5.690096\n", + " acald_e\n", + " 9.701650\n", " \n", " \n", " 15\n", " nh4_ko\n", " glc_ko\n", " akg_e\n", - " 4.689488\n", + " 4.704342\n", " \n", " \n", " 1\n", " glc_ko\n", " nh4_ko\n", " glu__L_e\n", - " 4.610779\n", + " 4.642087\n", " \n", " \n", - " 2\n", + " 13\n", + " nh4_ko\n", " glc_ko\n", + " ac_e\n", + " 2.696120\n", + " \n", + " \n", + " 2\n", " nh4_ko\n", + " glc_ko\n", " h2o_e\n", - " 2.254232\n", + " 2.610785\n", + " \n", + " \n", + " 4\n", + " nh4_ko\n", + " glc_ko\n", + " h_e\n", + " 2.547897\n", " \n", " \n", "\n", @@ -1921,18 +1797,18 @@ ], "text/plain": [ " donor receiver compound rate\n", - "14 glc_ko nh4_ko acald_e 31.460909\n", - "13 nh4_ko glc_ko ac_e 21.026083\n", - "4 nh4_ko glc_ko h_e 20.838688\n", - "18 nh4_ko glc_ko etoh_e 15.584869\n", - "6 nh4_ko glc_ko lac__D_e 5.896268\n", - "12 glc_ko nh4_ko pyr_e 5.690096\n", - "15 nh4_ko glc_ko akg_e 4.689488\n", - "1 glc_ko nh4_ko glu__L_e 4.610779\n", - "2 glc_ko nh4_ko h2o_e 2.254232" + "12 nh4_ko glc_ko pyr_e 24.884385\n", + "6 glc_ko nh4_ko lac__D_e 24.721311\n", + "18 nh4_ko glc_ko etoh_e 12.124982\n", + "14 glc_ko nh4_ko acald_e 9.701650\n", + "15 nh4_ko glc_ko akg_e 4.704342\n", + "1 glc_ko nh4_ko glu__L_e 4.642087\n", + "13 nh4_ko glc_ko ac_e 2.696120\n", + "2 nh4_ko glc_ko h2o_e 2.610785\n", + "4 nh4_ko glc_ko h_e 2.547897" ] }, - "execution_count": 24, + "execution_count": 58, "metadata": {}, "output_type": "execute_result" } @@ -1951,7 +1827,7 @@ }, { "cell_type": "code", - "execution_count": 25, + "execution_count": 59, "id": "26e96715", "metadata": { "scrolled": true @@ -1967,12 +1843,12 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "a91a00f2cf364dbd8bf2d34891fc4672", + "model_id": "58c1323d2e4c444f9e90aea6adefeb26", "version_major": 2, "version_minor": 0 }, "text/plain": [ - "Builder(reaction_data={'ACALD': -15.876039737077187, 'ACALDt': -31.460908810361047, 'ACKr': 21.026083388520718…" + "Builder(reaction_data={'ACALD': 2.4233312762522647, 'ACALDt': -9.701650317231756, 'ACKr': 2.6961195998247263, …" ] }, "metadata": {}, @@ -1990,7 +1866,7 @@ }, { "cell_type": "code", - "execution_count": 26, + "execution_count": 60, "id": "3fe40d10", "metadata": {}, "outputs": [ @@ -2004,12 +1880,12 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "e95a0848c5c244fba725f566d55e88bf", + "model_id": "23e22a45efbc417fab78caf8968134f4", "version_major": 2, "version_minor": 0 }, "text/plain": [ - "Builder(reaction_data={'ACALD': 15.876039737077235, 'ACALDt': 31.460908810361047, 'ACKr': -21.026083388520718,…" + "Builder(reaction_data={'ACALD': -2.4233312762522647, 'ACALDt': 9.701650317231756, 'ACKr': -2.6961195998247263,…" ] }, "metadata": {}, @@ -2036,7 +1912,7 @@ }, { "cell_type": "code", - "execution_count": 27, + "execution_count": 61, "id": "71695f63", "metadata": {}, "outputs": [ @@ -2044,11 +1920,9 @@ "name": "stdout", "output_type": "stream", "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", "Strain\tMin\tMax\n", - "glc_ko\t0.0%\t99.9%\n", - "nh4_ko\t0.1%\t100.0%\n" + "glc_ko\t0.4%\t98.3%\n", + "nh4_ko\t1.7%\t99.6%\n" ] } ], @@ -2081,7 +1955,7 @@ }, { "cell_type": "code", - "execution_count": 28, + "execution_count": 62, "id": "34220805", "metadata": {}, "outputs": [], @@ -2099,19 +1973,19 @@ }, { "cell_type": "code", - "execution_count": 29, + "execution_count": 63, "id": "1c660055", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "objective: 0.40757209363986224\n", + "objective: 0.828309078247319\n", "Status: OPTIMAL\n", "Method:FBA" ] }, - "execution_count": 29, + "execution_count": 63, "metadata": {}, "output_type": "execute_result" } @@ -2125,7 +1999,7 @@ }, { "cell_type": "code", - "execution_count": 30, + "execution_count": 64, "id": "ecb0bce0", "metadata": {}, "outputs": [ @@ -2160,11 +2034,11 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 0.407572\n", + " 0.100000\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 0.407572\n", + " 0.728309\n", " \n", " \n", "\n", @@ -2173,11 +2047,11 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.100000\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.728309" ] }, - "execution_count": 30, + "execution_count": 64, "metadata": {}, "output_type": "execute_result" } @@ -2196,23 +2070,10 @@ }, { "cell_type": "code", - "execution_count": 31, + "execution_count": 65, "id": "7ecc37ca", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqz1ce3qk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwm8gh3y5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - } - ], + "outputs": [], "source": [ "community = CommunityModel([glc_ko, nh4_ko],\n", " add_compartments=True,\n", @@ -2222,7 +2083,7 @@ }, { "cell_type": "code", - "execution_count": 32, + "execution_count": 66, "id": "77f8eed9", "metadata": {}, "outputs": [ @@ -2230,7 +2091,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.36it/s]\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.30it/s]\n" ] } ], @@ -2241,7 +2102,7 @@ }, { "cell_type": "code", - "execution_count": 33, + "execution_count": 67, "id": "7d604601", "metadata": {}, "outputs": [ @@ -2249,7 +2110,7 @@ "name": "stdout", "output_type": "stream", "text": [ - "objective: 0.40757209363986224\n", + "objective: 0.4075720936398621\n", "Status: OPTIMAL\n", "Method:FBA\n" ] @@ -2302,7 +2163,7 @@ "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" ] }, - "execution_count": 33, + "execution_count": 67, "metadata": {}, "output_type": "execute_result" } @@ -2315,7 +2176,7 @@ }, { "cell_type": "code", - "execution_count": 34, + "execution_count": 68, "id": "6402d86c", "metadata": {}, "outputs": [ @@ -2381,7 +2242,7 @@ "community_growth {'Biomass_glc_ko': -1, 'Biomass_nh4_ko': -1} {} " ] }, - "execution_count": 34, + "execution_count": 68, "metadata": {}, "output_type": "execute_result" } @@ -2400,7 +2261,7 @@ }, { "cell_type": "code", - "execution_count": 35, + "execution_count": 69, "id": "575721c6", "metadata": {}, "outputs": [ @@ -2457,7 +2318,7 @@ "community_growth 0.105388" ] }, - "execution_count": 35, + "execution_count": 69, "metadata": {}, "output_type": "execute_result" } @@ -2487,7 +2348,7 @@ }, { "cell_type": "code", - "execution_count": 36, + "execution_count": 70, "id": "45d28b6e", "metadata": {}, "outputs": [ @@ -2495,15 +2356,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 6.37it/s]\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.69it/s]\n" ] }, { @@ -2554,7 +2407,7 @@ "nh4_ko {'glc_ko': 1.0}" ] }, - "execution_count": 36, + "execution_count": 70, "metadata": {}, "output_type": "execute_result" } @@ -2573,36 +2426,10 @@ }, { "cell_type": "code", - "execution_count": 37, + "execution_count": 71, "id": "f779b482", "metadata": {}, "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk29vpt4n.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzwfubp6w.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphldkumdm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8gie1ue3.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpreyygnbm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0b709klz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, { "data": { "text/html": [ @@ -2634,11 +2461,11 @@ " \n", " \n", " glc_ko\n", - " {'ac_e': 0.06, 'acald_e': 0.28, 'akg_e': 0.2, ...\n", + " {'ac_e': 0.18, 'acald_e': 0.26, 'akg_e': 0.1, ...\n", " \n", " \n", " nh4_ko\n", - " {'ac_e': 0.0, 'acald_e': 0.0, 'akg_e': 0.0, 'c...\n", + " {'ac_e': 0.07692307692307693, 'acald_e': 0.076...\n", " \n", " \n", "\n", @@ -2647,11 +2474,11 @@ "text/plain": [ " Value\n", "Attribute \n", - "glc_ko {'ac_e': 0.06, 'acald_e': 0.28, 'akg_e': 0.2, ...\n", - "nh4_ko {'ac_e': 0.0, 'acald_e': 0.0, 'akg_e': 0.0, 'c..." + "glc_ko {'ac_e': 0.18, 'acald_e': 0.26, 'akg_e': 0.1, ...\n", + "nh4_ko {'ac_e': 0.07692307692307693, 'acald_e': 0.076..." ] }, - "execution_count": 37, + "execution_count": 71, "metadata": {}, "output_type": "execute_result" } @@ -2670,26 +2497,26 @@ { "data": { "text/plain": [ - "{'ac_e': 0.06,\n", - " 'acald_e': 0.28,\n", - " 'akg_e': 0.2,\n", + "{'ac_e': 0.18,\n", + " 'acald_e': 0.26,\n", + " 'akg_e': 0.1,\n", " 'co2_e': 0.0,\n", - " 'etoh_e': 0.17,\n", + " 'etoh_e': 0.39,\n", " 'for_e': 0.0,\n", " 'fru_e': 0.0,\n", " 'fum_e': 0.0,\n", " 'glc__D_e': 0.0,\n", " 'gln__L_e': 0.0,\n", " 'glu__L_e': 0.0,\n", - " 'h_e': 0.05,\n", - " 'h2o_e': 0.09,\n", - " 'lac__D_e': 0.24,\n", + " 'h_e': 0.09,\n", + " 'h2o_e': 0.13,\n", + " 'lac__D_e': 0.25,\n", " 'mal__L_e': 0.0,\n", " 'nh4_e': 1.0,\n", - " 'o2_e': 0.94,\n", + " 'o2_e': 0.89,\n", " 'pi_e': 1.0,\n", - " 'pyr_e': 0.3,\n", - " 'succ_e': 0.08}" + " 'pyr_e': 0.27,\n", + " 'succ_e': 0.03}" ] }, "execution_count": 38, @@ -2710,8 +2537,8 @@ { "data": { "text/plain": [ - "{'ac_e': 0.0,\n", - " 'acald_e': 0.0,\n", + "{'ac_e': 0.07692307692307693,\n", + " 'acald_e': 0.07692307692307693,\n", " 'akg_e': 0.0,\n", " 'co2_e': 0.0,\n", " 'etoh_e': 0.0,\n", @@ -2726,9 +2553,9 @@ " 'lac__D_e': 0.0,\n", " 'mal__L_e': 0.0,\n", " 'nh4_e': 0.0,\n", - " 'o2_e': 0.0,\n", + " 'o2_e': 0.07692307692307693,\n", " 'pi_e': 1.0,\n", - " 'pyr_e': 0.0,\n", + " 'pyr_e': 0.07692307692307693,\n", " 'succ_e': 0.0}" ] }, @@ -2755,32 +2582,6 @@ "id": "095e8c80", "metadata": {}, "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpocp3cfxi.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp92qw9y9b.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpigwu83g3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppbp1791u.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpanlc_ioh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphrvcqeth.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, { "data": { "text/html": [ @@ -2857,75 +2658,6 @@ "name": "stdout", "output_type": "stream", "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4dvynhd_.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdln1d9yn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqvad029b.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqoc_b7uw.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8g_f0mu0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl4kjrjo3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpodxpo4re.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6_m2cck2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcivs_dk8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2fgz5fts.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfh7s1z14.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy8l4qeo9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr3jxc3_d.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyunwlm_i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpijaen0n7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaa3pm_v5.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj7iciq21.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4xetwaml.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9byblcdr.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfn5t3nza.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpashf3mvp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", "0.2857142857142857\n" ] }, @@ -2960,11 +2692,11 @@ " \n", " \n", " community_medium\n", - " {gln, pi, glc}\n", + " {o2, pi, glu}\n", " \n", " \n", " individual_media\n", - " {'glc_ko': {'o2', 'akg', 'nh4', 'pi'}, 'nh4_ko...\n", + " {'glc_ko': {'pi', 'pyr', 'nh4', 'o2'}, 'nh4_ko...\n", " \n", " \n", "\n", @@ -2973,8 +2705,8 @@ "text/plain": [ " Value\n", "Attribute \n", - "community_medium {gln, pi, glc}\n", - "individual_media {'glc_ko': {'o2', 'akg', 'nh4', 'pi'}, 'nh4_ko..." + "community_medium {o2, pi, glu}\n", + "individual_media {'glc_ko': {'pi', 'pyr', 'nh4', 'o2'}, 'nh4_ko..." ] }, "execution_count": 41, @@ -2997,7 +2729,7 @@ { "data": { "text/plain": [ - "{'akg', 'nh4', 'o2', 'pi'}" + "{'nh4', 'o2', 'pi', 'pyr'}" ] }, "execution_count": 42, @@ -3029,22 +2761,6 @@ "source": [ "MRO.individual_media.nh4_ko" ] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "2eb4a9d2", - "metadata": {}, - "outputs": [], - "source": [] - }, - { - "cell_type": "code", - "execution_count": null, - "id": "e1e85c3c", - "metadata": {}, - "outputs": [], - "source": [] } ], "metadata": { diff --git a/examples/09-crossfeeding.ipynb b/examples/09-crossfeeding.ipynb index 490f7038..748b8b48 100644 --- a/examples/09-crossfeeding.ipynb +++ b/examples/09-crossfeeding.ipynb @@ -142,20 +142,7 @@ "execution_count": 5, "id": "726079e0", "metadata": {}, - "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp52jr2h38.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7_8udlxf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - } - ], + "outputs": [], "source": [ "ec1 = wildtype.copy()\n", "ec1.id = 'ec1'\n", @@ -179,15 +166,6 @@ "scrolled": true }, "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpno2v1xi0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, { "data": { "text/html": [ @@ -394,7 +372,7 @@ "source": [ "problem = GKOProblem(wildtype,\n", " [f1,f2],\n", - " candidate_max_size = 30)\n" + " candidate_max_size = 50)\n" ] }, { @@ -414,7 +392,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "100%|███████████████████████████████████████| 137/137 [00:00<00:00, 2722.75it/s]" + "100%|███████████████████████████████████████| 137/137 [00:00<00:00, 2197.73it/s]" ] }, { @@ -435,962 +413,63 @@ "name": "stdout", "output_type": "stream", "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0lq4wf_a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw6bbk62k.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3jnvqy_p.lp\n", - "Reading time = 0.01 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6c9ebryt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5c3wmxym.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphwixz8t3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxnosy9vc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkqxkxz3a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfez5wsxk.lp\n", - "Reading time = 0.01 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwoz22a25.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyi629nd4.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9q4lggki.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_menbojx.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdad_tt1n.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpep63916e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw3f2ts06.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxkyh018x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6_600jap.lp\n", - "Reading time = 0.01 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2hh42y9h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbotsgc1e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg3il1llb.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptl2iut7t.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl256e4l_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9nxl0xab.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpchwaep9p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9wnln8qq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpurvvfrbf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy6j1vytv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpghlrvql6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprgull_gf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", "Eval(s)| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev|\n", - " 100| 0.000000 0.873922 0.065209 0.222020 0.300277| 1.000000 30.000000 16.000000 15.620000 9.447518|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmb53smhz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv0tzc9ca.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1i_jzx08.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu84phupy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnjws9rxt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0kuwtm5m.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxnl6jt42.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyvhrdxdd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpser1i5dt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp47yj14t_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0pmc5ths.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg_1b4gsz.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpat3acpyu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfrxqs9ll.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu1mr_xvc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq6p363uj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyzlycrky.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpudr4h687.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9b9ie7p3.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa0lbhuvk.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeet6t4jj.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm5387uaj.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprc8qme3y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5anqx6n3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpivblmpb8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw9qkp56_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp39qlugi8.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy9tau5s8.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0zeqt_yp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi05d373n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 200| 0.000000 0.873922 0.196462 0.333796 0.346888| 1.000000 30.000000 19.000000 17.120000 10.100772|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjdpoifp6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyuc5ipul.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp97pgru4u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph6d68t_v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5zl3uz8u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxoghllxe.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0li54sqc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmposoosb7f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1k2mwdx2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgn8i9aih.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuwkf9v0_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj0dla6o7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzti94_9v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpid6bakix.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpboyvk5ji.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3ka5no3e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxhxom9kk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoohmlfva.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpynzdgfla.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzjl6dy5u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpipktagkg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxvhag9nh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg9yy9a76.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1rdatc7c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6kpy196y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt3k6zv3t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3cfbpv2e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprjoslfe3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9qfq1pib.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9mrkhlj6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 300| 0.000000 0.873922 0.068455 0.295471 0.363284| 1.000000 30.000000 26.000000 20.520000 10.059304|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpza2nlwxx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprkukgcy3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmped_61ltm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsmcs0_33.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpegnr89u_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzbghnwfx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmlxu5334.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk1cl2ly5.lp\n", - "Reading time = 0.02 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz0q_oc6a.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.03 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprds5jug3.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwpt5jodw.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvygrn10p.lp\n", - "Reading time = 0.01 seconds\n", - "Reading time = 0.01 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplkyq2f1u.lp\n", - "Reading time = 0.02 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv93bknet.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppyz82g64.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppr5nszze.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7dvvgxgf.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpowlsj5o8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpak_461e7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaau41pxw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1_za0nco.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_y30k93r.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7shk6j7d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp09xbvmr7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmjn16fhb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg4pk666o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjc3r0bcu.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiir2mdy5.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfn5cs1z9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_rx_phoq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 400| 0.000000 0.873922 0.000000 0.171581 0.314601| 2.000000 30.000000 29.000000 25.490000 7.986858|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkir13m7i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppmpgp2g3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfjjui_7l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeb4o2duh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyniowia_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq7vb6lii.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph18hdoyi.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuljhjwo6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb_g77wbj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd8he94_0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfe513gkw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmvimn6le.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcma4i9n9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxj4a6czt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa7na5kv8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp05om_dgl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4c293vhx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpha447385.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe7hzmj35.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_qu7qy7p.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3itrlqkd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyo3apifv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptg_po8b3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmlr94gue.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9iz657kd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsifv8bxq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1kt9r0n9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmz8h_pm9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmpi27o72.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa0ryu6vq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 500| 0.000000 0.873922 0.000000 0.170146 0.314288| 2.000000 30.000000 30.000000 26.180000 8.162573|\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwp107rlb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjypu2ygi.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnhy9stqv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpncxkg0nv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb5cmplhy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1zgqph3f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz4z94wa4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpskqopetm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf1nwsx_2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa_tywrza.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps0yt72wl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu1npndmy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgfqjcl2_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprndh0plk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjz7xo9rv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz6_ggbse.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphsag4lz4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5pimgs6v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnq71wv62.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbrejwxjv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnfkgiexd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpafldcdrt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaxoi7jj3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn1gb3lqe.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfbmsw7c0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfidox7sq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjm2y55nl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptc82j46y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp63u2akm9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwq63ehyv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 600| 0.000000 0.873922 0.192520 0.340928 0.361032| 2.000000 30.000000 29.000000 22.230000 9.627933|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnzilsju1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeb898kf0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9qbg72d6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprhw5via3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxdd2dtkb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprusolbyv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp74i1abqq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv10ytzs0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp21asxcty.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa6d9ztld.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp47qjuar.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwm2wqko3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp212v7pdd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph4d6exwd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprmplhv7v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe6bvqo_f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7nu5re5c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp712c0gi2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8wel7v5i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkja5bp47.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp513odgmg.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiqn3sd3a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp94id5y8t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4ekfnsaq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt3zvwtz7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuxse_ewe.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjvly43y3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp91096trp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwrv0u88e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm1knfo72.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 700| 0.000000 0.873922 0.617037 0.546602 0.291302| 2.000000 30.000000 20.000000 18.570000 9.060083|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7_h0tahd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxp6oh8pf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7pjeg15j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9xvkau88.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_gwmxnpl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp746t3j9n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqnb2m68c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbfuq53as.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmba8o0ov.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq7r0yamn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpygmclbcb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfokjywfe.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2jz4wczo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw941q777.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptosncwke.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphfgpyq73.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6hd130s_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1ofzz64y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_rhe8r67.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxoz96z6z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpntve1rns.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6hl4wzee.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzx6_muff.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprhlwpcu8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpln7p_0y2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkajav0qp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy6stp1pu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6x18aa4s.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzeyw81e3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1ki0pxi_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 800| 0.167609 0.873922 0.617037 0.590059 0.259511| 3.000000 30.000000 20.000000 19.790000 7.741182|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvfuhe7zb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfn1u0ugv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmepalkb8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphkpgab9l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfolea5qg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp41adxrs2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5s0n4uiw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnju1r77k.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd_d2zud8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6l9k9oh0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd7iyhct_.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgnmmji4e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaa0y4uo_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8wg8o6lj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprwwcb3in.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq_ul9x71.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_wyzoqpb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_rde5vv3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbki01_m1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpttt1c5ur.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplzndvgic.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk91m5qnv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprx9nuvli.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0g4k489x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpema3toa0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdl52d2d9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr2jxbomv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6wbluxid.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9g7pbmyx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpehmcu9mr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 900| 0.167609 0.873922 0.635381 0.584310 0.276149| 6.000000 30.000000 22.000000 21.070000 7.769498|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj6mtutks.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4powc0zk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgrvh46ic.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2sl3f1b6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7sv3varh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqov4qddo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj57g3pyy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa_err8ne.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkq0eseam.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpudhqlb97.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdkstqvqo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6aldsp5r.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpli1l0ot_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt45we9jw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi4_ijbm5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxeo8y0dk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps7m94czs.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkkk05sq4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmposos0q1b.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxc171zcz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp53uoih4i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpugf2ttd6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppu_5sujv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxl70tw9i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6rjubh0x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0mn7b0mo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphr2_4f8d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp63n884uv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4p4yzs0l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpysge88nx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - " 1000| 0.167609 0.873922 0.374230 0.538654 0.259960| 11.000000 30.000000 27.000000 23.960000 5.870128|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgnq2s1du.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" + " 100| 0.000000 0.873922 0.000000 0.139131 0.243433| 1.000000 50.000000 27.000000 24.910000 14.832461|\n", + " 200| 0.000000 0.873922 0.196462 0.252733 0.255846| 1.000000 50.000000 13.500000 20.180000 16.669361|\n", + " 300| 0.000000 0.873922 0.211663 0.353210 0.318573| 1.000000 50.000000 17.000000 21.520000 16.222503|\n", + " 400| 0.000000 0.873922 0.374230 0.390360 0.341932| 1.000000 50.000000 21.000000 24.030000 16.826441|\n", + " 500| 0.000000 0.873922 0.374230 0.397523 0.340082| 2.000000 50.000000 21.500000 24.690000 16.496481|\n", + " 600| 0.000000 0.873922 0.350513 0.331092 0.327334| 3.000000 50.000000 26.000000 28.780000 16.620217|\n", + " 700| 0.000000 0.873922 0.000000 0.265574 0.330570| 3.000000 50.000000 47.000000 33.640000 16.697617|\n", + " 800| 0.000000 0.873922 0.000000 0.221614 0.316088| 6.000000 50.000000 48.000000 36.320000 15.811312|\n", + " 900| 0.000000 0.873922 0.000000 0.193541 0.304936| 7.000000 50.000000 49.000000 38.570000 15.257297|\n", + " 1000| 0.000000 0.873922 0.000000 0.142570 0.278743| 8.000000 50.000000 50.000000 42.120000 14.027316|\n", + " 1100| 0.000000 0.873922 0.000000 0.057600 0.188195| 9.000000 50.000000 50.000000 46.910000 9.396909|\n", + " 1200| 0.000000 0.873922 0.000000 0.065348 0.191490| 9.000000 50.000000 50.000000 46.410000 9.684106|\n", + " 1300| 0.000000 0.873922 0.000000 0.082827 0.222156| 9.000000 50.000000 50.000000 45.640000 10.836531|\n", + " 1400| 0.000000 0.873922 0.000000 0.078129 0.218867| 9.000000 50.000000 50.000000 45.960000 10.482290|\n", + " 1500| 0.000000 0.873922 0.000000 0.080059 0.219020| 9.000000 50.000000 50.000000 45.860000 10.468066|\n", + " 1600| 0.000000 0.873922 0.000000 0.090751 0.227000| 9.000000 50.000000 50.000000 45.240000 10.943601|\n", + " 1700| 0.000000 0.873922 0.000000 0.095364 0.239419| 9.000000 50.000000 50.000000 45.250000 11.178886|\n", + " 1800| 0.000000 0.873922 0.000000 0.109855 0.252298| 9.000000 50.000000 50.000000 44.440000 11.772273|\n", + " 1900| 0.000000 0.873922 0.000000 0.102677 0.248593| 9.000000 50.000000 50.000000 44.900000 11.425848|\n", + " 2000| 0.000000 0.873922 0.000000 0.092484 0.246764| 9.000000 50.000000 50.000000 45.660000 10.985645|\n", + " 2100| 0.000000 0.873922 0.000000 0.092520 0.246780| 9.000000 50.000000 50.000000 45.670000 10.970921|\n", + " 2200| 0.000000 0.873922 0.000000 0.114860 0.275620| 9.000000 50.000000 50.000000 44.930000 12.014371|\n", + " 2300| 0.000000 0.873922 0.000000 0.118989 0.280689| 9.000000 50.000000 50.000000 44.900000 11.962859|\n", + " 2400| 0.000000 0.873922 0.000000 0.117064 0.280838| 9.000000 50.000000 50.000000 44.960000 11.973237|\n", + " 2500| 0.000000 0.873922 0.000000 0.129394 0.288685| 9.000000 50.000000 50.000000 44.320000 12.302748|\n", + " 2600| 0.000000 0.873922 0.000000 0.147377 0.302901| 9.000000 50.000000 50.000000 43.730000 12.674269|\n", + " 2700| 0.000000 0.873922 0.000000 0.150088 0.304025| 9.000000 50.000000 50.000000 43.620000 12.640237|\n", + " 2800| 0.000000 0.873922 0.000000 0.235088 0.342419| 9.000000 50.000000 50.000000 40.020000 13.902503|\n", + " 2900| 0.000000 0.873922 0.000000 0.202618 0.319993| 9.000000 50.000000 50.000000 41.310000 13.243636|\n", + " 3000| 0.000000 0.873922 0.196462 0.326035 0.345409| 9.000000 50.000000 39.000000 36.230000 14.084641|\n", + " 3100| 0.000000 0.873922 0.374230 0.492858 0.324564| 8.000000 50.000000 30.000000 30.160000 13.029751|\n", + " 3200| 0.182527 0.873922 0.211663 0.478488 0.314659| 8.000000 50.000000 34.000000 32.440000 13.642815|\n", + " 3300| 0.182527 0.873922 0.519491 0.522958 0.315752| 8.000000 50.000000 29.000000 30.820000 13.639927|\n", + " 3400| 0.182527 0.873922 0.211663 0.494350 0.321601| 8.000000 50.000000 35.000000 32.520000 13.948104|\n", + " 3500| 0.182527 0.873922 0.729735 0.558824 0.319162| 8.000000 50.000000 29.000000 29.590000 13.028503|\n", + " 3600| 0.182527 0.873922 0.796841 0.583404 0.311285| 8.000000 50.000000 28.500000 28.940000 12.594300|\n", + " 3700| 0.182527 0.873922 0.796841 0.570842 0.316299| 8.000000 50.000000 29.500000 29.780000 12.633748|\n", + " 3800| 0.182527 0.873922 0.814298 0.592014 0.317421| 8.000000 50.000000 29.500000 30.400000 12.545119|\n", + " 3900| 0.192520 0.873922 0.814298 0.586601 0.319686| 8.000000 50.000000 31.000000 30.700000 12.088424|\n", + " 4000| 0.192520 0.873922 0.814298 0.588297 0.318581| 8.000000 50.000000 31.000000 31.580000 12.439598|\n", + " 4100| 0.192520 0.873922 0.814298 0.576526 0.322905| 8.000000 50.000000 32.500000 32.600000 12.675962|\n", + " 4200| 0.000000 0.873922 0.858307 0.639750 0.312014| 8.000000 50.000000 30.000000 31.280000 12.782864|\n", + " 4300| 0.000000 0.873922 0.858307 0.613869 0.320631| 8.000000 50.000000 31.000000 32.580000 12.893549|\n", + " 4400| 0.192520 0.873922 0.814298 0.576304 0.324719| 8.000000 50.000000 33.000000 34.650000 12.492698|\n", + " 4500| 0.192520 0.873922 0.495524 0.529611 0.327419| 8.000000 50.000000 38.500000 36.610000 12.712903|\n", + " 4600| 0.192520 0.873922 0.814298 0.558426 0.327530| 8.000000 50.000000 35.000000 36.260000 12.128990|\n", + " 4700| 0.192520 0.873922 0.863813 0.632796 0.312936| 8.000000 50.000000 34.000000 34.640000 11.258348|\n", + " 4800| 0.192520 0.873922 0.833819 0.569717 0.325147| 9.000000 50.000000 35.500000 36.240000 11.402737|\n", + " 4900| 0.192520 0.873922 0.717202 0.540942 0.326207| 9.000000 50.000000 37.000000 38.110000 10.238061|\n", + " 5000| 0.192520 0.873922 0.211663 0.497099 0.320723| 27.000000 50.000000 43.000000 40.960000 7.266251|\n" ] } ], "source": [ "from mewpy.optimization import EA\n", - "ea = EA(problem, max_generations=10)\n", + "ea = EA(problem, max_generations=50)\n", "gkos = ea.run(simplify=False)" ] }, @@ -1438,38 +517,38 @@ " \n", " \n", " 0\n", - " {'b1276': 0, 'b0809': 0, 'b4154': 0, 'b0810': ...\n", - " 30\n", - " 0.374230\n", - " 30.0\n", + " {'b3739': 0, 'b2284': 0, 'b2463': 0, 'b3114': ...\n", + " 50\n", + " 0.211663\n", + " 50.0\n", " \n", " \n", " 1\n", - " {'b1817': 0, 'b1276': 0, 'b1723': 0, 'b0809': ...\n", - " 22\n", - " 0.873922\n", - " 22.0\n", + " {'b3739': 0, 'b2284': 0, 'b1524': 0, 'b4232': ...\n", + " 50\n", + " 0.211663\n", + " 50.0\n", " \n", " \n", " 2\n", - " {'b0356': 0, 'b0726': 0, 'b4395': 0, 'b0903': ...\n", - " 23\n", - " 0.782351\n", - " 23.0\n", + " {'b3739': 0, 'b0903': 0, 'b2463': 0, 'b1524': ...\n", + " 35\n", + " 0.873922\n", + " 35.0\n", " \n", " \n", " 3\n", - " {'b1276': 0, 'b0809': 0, 'b4154': 0, 'b0810': ...\n", - " 27\n", - " 0.680085\n", - " 27.0\n", + " {'b3739': 0, 'b0903': 0, 'b4152': 0, 'b2463': ...\n", + " 34\n", + " 0.873922\n", + " 34.0\n", " \n", " \n", " 4\n", - " {'b2465': 0, 'b2463': 0, 'b1676': 0, 'b1723': ...\n", - " 17\n", - " 0.873922\n", - " 17.0\n", + " {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b4152': ...\n", + " 47\n", + " 0.211663\n", + " 47.0\n", " \n", " \n", " ...\n", @@ -1479,60 +558,60 @@ " ...\n", " \n", " \n", - " 59\n", - " {'b3738': 0, 'b4154': 0, 'b3925': 0, 'b2579': ...\n", - " 26\n", - " 0.374230\n", - " 26.0\n", + " 70\n", + " {'b3739': 0, 'b2284': 0, 'b3114': 0, 'b1524': ...\n", + " 50\n", + " 0.200142\n", + " 50.0\n", " \n", " \n", - " 60\n", - " {'b2465': 0, 'b3403': 0, 'b4395': 0, 'b0485': ...\n", - " 11\n", + " 71\n", + " {'b3739': 0, 'b4152': 0, 'b2463': 0, 'b1524': ...\n", + " 27\n", " 0.873922\n", - " 11.0\n", + " 27.0\n", " \n", " \n", - " 61\n", - " {'b1676': 0, 'b1723': 0, 'b0755': 0, 'b2976': ...\n", - " 11\n", - " 0.873922\n", - " 11.0\n", + " 72\n", + " {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b2279': ...\n", + " 50\n", + " 0.192520\n", + " 50.0\n", " \n", " \n", - " 62\n", - " {'b3738': 0, 'b1276': 0, 'b3870': 0, 'b2288': ...\n", - " 30\n", - " 0.167609\n", - " 30.0\n", + " 73\n", + " {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b2279': ...\n", + " 50\n", + " 0.192520\n", + " 50.0\n", " \n", " \n", - " 63\n", - " {'b1817': 0, 'b0809': 0, 'b0903': 0, 'b2464': ...\n", - " 23\n", - " 0.447376\n", - " 23.0\n", + " 74\n", + " {'b3739': 0, 'b2284': 0, 'b2279': 0, 'b4232': ...\n", + " 42\n", + " 0.211663\n", + " 42.0\n", " \n", " \n", "\n", - "

64 rows × 4 columns

\n", + "

75 rows × 4 columns

\n", "" ], "text/plain": [ " Modification Size TargetFlux Size\n", - "0 {'b1276': 0, 'b0809': 0, 'b4154': 0, 'b0810': ... 30 0.374230 30.0\n", - "1 {'b1817': 0, 'b1276': 0, 'b1723': 0, 'b0809': ... 22 0.873922 22.0\n", - "2 {'b0356': 0, 'b0726': 0, 'b4395': 0, 'b0903': ... 23 0.782351 23.0\n", - "3 {'b1276': 0, 'b0809': 0, 'b4154': 0, 'b0810': ... 27 0.680085 27.0\n", - "4 {'b2465': 0, 'b2463': 0, 'b1676': 0, 'b1723': ... 17 0.873922 17.0\n", + "0 {'b3739': 0, 'b2284': 0, 'b2463': 0, 'b3114': ... 50 0.211663 50.0\n", + "1 {'b3739': 0, 'b2284': 0, 'b1524': 0, 'b4232': ... 50 0.211663 50.0\n", + "2 {'b3739': 0, 'b0903': 0, 'b2463': 0, 'b1524': ... 35 0.873922 35.0\n", + "3 {'b3739': 0, 'b0903': 0, 'b4152': 0, 'b2463': ... 34 0.873922 34.0\n", + "4 {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b4152': ... 47 0.211663 47.0\n", ".. ... ... ... ...\n", - "59 {'b3738': 0, 'b4154': 0, 'b3925': 0, 'b2579': ... 26 0.374230 26.0\n", - "60 {'b2465': 0, 'b3403': 0, 'b4395': 0, 'b0485': ... 11 0.873922 11.0\n", - "61 {'b1676': 0, 'b1723': 0, 'b0755': 0, 'b2976': ... 11 0.873922 11.0\n", - "62 {'b3738': 0, 'b1276': 0, 'b3870': 0, 'b2288': ... 30 0.167609 30.0\n", - "63 {'b1817': 0, 'b0809': 0, 'b0903': 0, 'b2464': ... 23 0.447376 23.0\n", + "70 {'b3739': 0, 'b2284': 0, 'b3114': 0, 'b1524': ... 50 0.200142 50.0\n", + "71 {'b3739': 0, 'b4152': 0, 'b2463': 0, 'b1524': ... 27 0.873922 27.0\n", + "72 {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b2279': ... 50 0.192520 50.0\n", + "73 {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b2279': ... 50 0.192520 50.0\n", + "74 {'b3739': 0, 'b2284': 0, 'b2279': 0, 'b4232': ... 42 0.211663 42.0\n", "\n", - "[64 rows x 4 columns]" + "[75 rows x 4 columns]" ] }, "execution_count": 11, @@ -1561,7 +640,7 @@ { "data": { "text/plain": [ - "objective: 0.3742298749331099\n", + "objective: 0.21166294973531075\n", "Status: OPTIMAL\n", "Method:FBA" ] @@ -1608,32 +687,20 @@ "source": [ "## Community mutants \n", "\n", - "We can now address our main goal, starting by defining a community model:" + "We can now address our main goal, starting by defining a community model. We will not impose a relative abundance (`merge_biomasses=False`), instead we will include in the optimization task the secondary implicit goal of \"minimizing the difference between the mutant growth\" using a regularized FBA. " ] }, { "cell_type": "code", - "execution_count": 14, + "execution_count": 36, "id": "a5ead7e5", "metadata": {}, "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvhc97k3s.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpor25pbg4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, { "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 4.98it/s]\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.66it/s]\n" ] } ], @@ -1641,7 +708,7 @@ "from mewpy.model import CommunityModel\n", "from mewpy.com import regComFBA\n", "\n", - "community= CommunityModel([ec1,ec2],flavor='cobra')\n", + "community= CommunityModel([ec1,ec2],merge_biomasses=False,flavor='cobra')\n", "sim = community.get_community_model()\n", "sim.set_environmental_conditions(medium)" ] @@ -1657,12 +724,12 @@ "- Maximize `ec2` growth while ensuring that `ec1` growth is above 0.1/h;\n", "- Maximize the total number of gene deletions.\n", "\n", - "We will be using a regularized Community FBA (regComFBA) to select a specific solution." + "We will be using a Regularized Community FBA (regComFBA) to select a specific solution." ] }, { "cell_type": "code", - "execution_count": 15, + "execution_count": 27, "id": "4f1a046b", "metadata": {}, "outputs": [], @@ -1680,7 +747,7 @@ }, { "cell_type": "code", - "execution_count": 16, + "execution_count": 28, "id": "bf6d8ef2", "metadata": {}, "outputs": [], @@ -1700,7 +767,7 @@ }, { "cell_type": "code", - "execution_count": 24, + "execution_count": 29, "id": "d0febc71", "metadata": {}, "outputs": [ @@ -1708,10025 +775,290 @@ "name": "stdout", "output_type": "stream", "text": [ - "Running NSGAII\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkazi8qj7.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd11ankpr.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnqrnmum4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe391nkt6.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy6mevu13.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp36_0yb7g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1p_dagii.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpatu8eaej.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc7bo18ho.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg1x331zy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppbjqz7w8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsdnp3s5x.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps87r9idr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvlj6kc2e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv6r3w6fd.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg5c4xrac.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptd4afm2n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppvwcmnz5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcji7g9st.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq8ayfm0q.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw9egm13y.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0n_9jdrq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpab4jz4rw.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpje85lkku.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjsosdf6n.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfjgchm7z.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph7c9v2kv.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmwz37nfl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsnh390df.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_r6pwo97.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6m5maaix.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd5ozkj91.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphf0f2fxs.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo3y4j7ao.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf4pbdhph.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9r6zdsx2.lp\n", - "Reading time = 0.00 seconds\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeitpt9t3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjt_bnlot.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2r2tc05w.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3xexwzun.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4orjs834.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6759yvjj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8kdtrekw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpae8a6aca.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp200ebgfp.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx0t32xue.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf3u8h790.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw8say0ky.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_gbd13r3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpryntnnwk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpllnvwq87.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpomy0sjny.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl45p8aqo.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpew4nj5u2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprx7lh0k2.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwk49o20d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp11bglsp4.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2ysyhk78.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdvk38di6.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppqh_7sl4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiopadgy6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj40kueo0.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnro5czo0.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprco4ri3u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyor2is_h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxjdmn711.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw5e0n8ll.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf2qurxmx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcb5k_iz2.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7mqv35xk.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzj48z65g.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7m_p5egc.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb261hl7n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphnr_5sdn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpon5w2qy0.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpounjkcr3.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx0p5fn4d.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp979ee82.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7ot1buwg.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmjlc9nix.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoqg8x3lp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpokflv9fb.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_vs0_7fx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaqbv836j.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp90zvu3i6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfkiypgmv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphd5mulnk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsteveh4x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcsee2il3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpevbej0ln.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Eval(s)| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev|\n", - " 100| 0.404115 0.411442 0.411442 0.411295 0.001026| 0.404115 0.411442 0.411442 0.411295 0.001026| 11.000000 30.000000 23.500000 22.860000 6.105768|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4h8po9hn.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz7x79qj1.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprqvxgjfq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbey0sxzg.lp\n", - "Reading time = 0.01 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppojf15eo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5h99q_n_.lp\n", - "Reading time = 0.01 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzq30vsko.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1kh3kdbl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxfwt_vuj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0_x8va8t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpas0_g8hr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk1zr5crn.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppc7w87ip.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp__5s0iue.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcli35k33.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp00qp52ud.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5paak4d5.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyd6r_c9g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiik4di4_.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpas5idnjb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd6i4_ybh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxgqcoxa9.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq2odrfzy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfwvh9mg6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa9izezx9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpltatq3jo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuq9vvatt.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf3_gojlb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8hidi_4e.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1_le02qg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkbphx1n0.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcifa669o.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvt7dm4w5.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0vkrl0ut.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptuoamfmc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkqo3ei2h.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyxaf_q_n.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptb671282.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2u5c3mf7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc7nm773j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5_alrvqq.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq9b8v9mg.lp\n" + "Building modification target list.\n" ] }, { - "name": "stdout", + "name": "stderr", "output_type": "stream", "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfue354az.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmputzt2oma.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphxzweerz.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsabqz5tw.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppyr1kds1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6dfyzi3o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5aanlv9l.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0chnshir.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj_ajo64a.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptv3ywqth.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw9wc7fbw.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppw3fxze6.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2ol_he9x.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppyjq0d8g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3wx1ckbh.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk6qnpaq8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7icxbw3l.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkaq756zs.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi6plz_fv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph8wgg3lp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxm0lgtq8.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuoc5sb30.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcusdz7jx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwni0bimz.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0ak3d557.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphohd68y8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcj1l_277.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn1qlb9z5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc42axfz4.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptg6qs66c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprco3722s.lp\n" + "100%|███████████████████████████████████████| 274/274 [00:00<00:00, 1762.72it/s]" ] }, { "name": "stdout", "output_type": "stream", "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp99d5glvv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp946fiy2o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmy7ebsoi.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphyk14nb2.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi7mmnr0n.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5005bioq.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfmkk8ahx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa0n97qom.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph5hiohom.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4fkkfedx.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0e9vywgh.lp\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeu_51x9z.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnuoboveh.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp85gywmm_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0rybrznt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdigcmvkz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_zf749ic.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - " 200| 0.131812 0.411442 0.411442 0.401994 0.048108| 0.131812 0.411442 0.411442 0.401994 0.048108| 13.000000 42.000000 26.500000 24.680000 5.858123|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7ce58w8w.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy5ez1721.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvx3bot6j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzvx7f3ql.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4eo09udu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpklasegru.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9pgeg2_n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3946kybm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9rqrhh4p.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjfawoje2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd68fczu4.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfwchahn6.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp11emac5i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2e49_vum.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb03si7cf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsf_j30iq.lp\n" + "Running NSGAII\n" ] }, { - "name": "stdout", + "name": "stderr", "output_type": "stream", "text": [ - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplegj84cb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf9rqdwfa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnuz_90ze.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps5u26wio.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp75fm1r8j.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_62i449h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpivdnrmg0.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf7djhr9v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyqcon0ee.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9n6cug4_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1js_elmj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpirafias1.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_9vlkci5.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzpd8pa9i.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptvvoy96c.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjki8wbe5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsc6o_hy2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsmyln6_t.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2mxe05u5.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprobggmd7.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6qnkac6x.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy18157pp.lp\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4mydd_82.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5f24h938.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpghb5y0k4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq50w6n5p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5tzdn1_q.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfcd5fri5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx5y2en1q.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgf80covw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi7fki37s.lp\n" + "\n" ] }, { "name": "stdout", "output_type": "stream", "text": [ - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp79z8y9a2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoe765k4d.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpursqpwkx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4ddax__1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5gc7h7sf.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmauo0ecx.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4imtpm3w.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy53zmz74.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprj6j2d2l.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuo31ozqo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu4_89u_y.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7gc9r0m7.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdui8jd_e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvja5sw_j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa0eaefk1.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8hoiqfn_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4v_1jqxt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2gpeqlfl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnu1_woh2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgsodc153.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbr5miy0v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpocql42q_.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyv4d8zvt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqq9v35la.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe4a7o2zs.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe77cidrd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfugxnkpw.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvdpfs4iz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" + "Eval(s)| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev|\n", + " 100| 0.411442 0.411442 0.411442 0.411442 0.000000| 0.411442 0.411442 0.411442 0.411442 0.000000| 27.000000 50.000000 41.000000 40.320000 7.630046|\n", + " 200| 0.000000 0.411442 0.411442 0.402029 0.058629| 0.000000 0.461758 0.411442 0.403716 0.057891| 27.000000 59.000000 44.000000 42.830000 6.959964|\n", + " 300| 0.000000 0.612274 0.411442 0.371122 0.125882| 0.000000 0.461758 0.411442 0.367826 0.126195| 27.000000 60.000000 46.000000 44.210000 7.426029|\n", + " 400| 0.000000 0.654500 0.411442 0.354860 0.158462| 0.000000 0.617272 0.411442 0.338266 0.152988| 27.000000 60.000000 47.000000 46.560000 7.885835|\n", + " 500| 0.000000 0.654500 0.411442 0.355879 0.170375| 0.000000 0.617272 0.411442 0.326564 0.159411| 32.000000 60.000000 48.000000 46.960000 8.522816|\n", + " 600| 0.000000 0.654500 0.411442 0.415296 0.116799| 0.005164 0.628294 0.411442 0.371218 0.117568| 32.000000 60.000000 48.000000 47.050000 7.567529|\n", + " 700| 0.184155 0.663398 0.411442 0.443853 0.128858| 0.108767 0.628294 0.411442 0.356126 0.139089| 32.000000 60.000000 49.000000 48.120000 6.061815|\n", + " 800| 0.116572 0.663398 0.497999 0.447072 0.148912| 0.108767 0.684855 0.306071 0.364165 0.151863| 34.000000 60.000000 49.000000 48.510000 5.189403|\n", + " 900| 0.116571 0.663398 0.516813 0.463270 0.166916| 0.108767 0.684856 0.306071 0.343208 0.170854| 34.000000 60.000000 48.000000 48.230000 5.840985|\n", + " 1000| 0.109701 0.663398 0.516813 0.450969 0.170855| 0.108767 0.691726 0.306071 0.353349 0.174729| 34.000000 60.000000 48.000000 48.400000 6.297619|\n" ] - }, + } + ], + "source": [ + "from mewpy.util.constants import EAConstants\n", + "EAConstants.DEBUG = True\n", + "\n", + "ea = EA(problem,\n", + " max_generations=10,\n", + " initial_population=init_pop[:100])\n", + "\n", + "solutions = ea.run(simplify=False)" + ] + }, + { + "cell_type": "markdown", + "id": "aa16fe03", + "metadata": {}, + "source": [ + "We may now have a look at the solutions as a dataframe or as a plot" + ] + }, + { + "cell_type": "code", + "execution_count": 30, + "id": "cf72f00d", + "metadata": {}, + "outputs": [ { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmj74baw5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6in8twq4.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx3z1tbgw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1mnh75du.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkur82eax.lp\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjjdnxg8_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2nh6y6h0.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpviyd6koy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj8y90ewh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwn3nitud.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmopmdwc9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo0t4o01f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdhvitr60.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps0cyjl1n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd78nmknv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - " 300| 0.000000 0.411442 0.411442 0.376864 0.095926| 0.000000 0.411442 0.411442 0.376864 0.095926| 12.000000 42.000000 28.000000 26.320000 6.602848|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzro0030u.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpunnmndot.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4vhnx7fb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp61z14cmp.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0j074phu.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp__2zcsf9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5963u35d.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6bs0hc67.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbhlj0z8r.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3ps2_217.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp08x3slas.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptndri_1v.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6d_08ffm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_ncy_1_v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaje6tvbc.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3nk9ed85.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfwe7b3j7.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoiizrj6g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdhrgtbvv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbzwkd6y7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9qxd0x1f.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, + "data": { + "text/html": [ + "
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ModificationSizeTargetFluxTargetFluxSize
0{'b0733_ec1': 0, 'b0755_ec2': 0, 'b3739_ec1': ...520.6633980.13137452.0
1{'b3236_ec2': 0, 'b2282_ec2': 0, 'b3212_ec2': ...600.4114420.41144260.0
2{'b3236_ec2': 0, 'b2282_ec2': 0, 'b3739_ec1': ...580.6122740.10876758.0
3{'b2282_ec2': 0, 'b0733_ec1': 0, 'b3212_ec2': ...490.1097010.69172649.0
4{'b0755_ec2': 0, 'b3739_ec1': 0, 'b2925_ec2': ...340.4114420.41144234.0
..................
81{'b3236_ec2': 0, 'b2282_ec2': 0, 'b0755_ec2': ...510.6172720.18415551.0
82{'b3236_ec2': 0, 'b2282_ec2': 0, 'b0733_ec1': ...580.4676500.28711358.0
83{'b0755_ec2': 0, 'b3739_ec1': 0, 'b2925_ec2': ...420.5168130.30607142.0
84{'b2282_ec2': 0, 'b3212_ec2': 0, 'b0755_ec2': ...440.5168130.30607044.0
85{'b2282_ec2': 0, 'b0755_ec2': 0, 'b4395_ec2': ...470.6047020.19672547.0
\n", + "

86 rows × 5 columns

\n", + "
" + ], + "text/plain": [ + " Modification Size TargetFlux \\\n", + "0 {'b0733_ec1': 0, 'b0755_ec2': 0, 'b3739_ec1': ... 52 0.663398 \n", + "1 {'b3236_ec2': 0, 'b2282_ec2': 0, 'b3212_ec2': ... 60 0.411442 \n", + "2 {'b3236_ec2': 0, 'b2282_ec2': 0, 'b3739_ec1': ... 58 0.612274 \n", + "3 {'b2282_ec2': 0, 'b0733_ec1': 0, 'b3212_ec2': ... 49 0.109701 \n", + "4 {'b0755_ec2': 0, 'b3739_ec1': 0, 'b2925_ec2': ... 34 0.411442 \n", + ".. ... ... ... \n", + "81 {'b3236_ec2': 0, 'b2282_ec2': 0, 'b0755_ec2': ... 51 0.617272 \n", + "82 {'b3236_ec2': 0, 'b2282_ec2': 0, 'b0733_ec1': ... 58 0.467650 \n", + "83 {'b0755_ec2': 0, 'b3739_ec1': 0, 'b2925_ec2': ... 42 0.516813 \n", + "84 {'b2282_ec2': 0, 'b3212_ec2': 0, 'b0755_ec2': ... 44 0.516813 \n", + "85 {'b2282_ec2': 0, 'b0755_ec2': 0, 'b4395_ec2': ... 47 0.604702 \n", + "\n", + " TargetFlux Size \n", + "0 0.131374 52.0 \n", + "1 0.411442 60.0 \n", + "2 0.108767 58.0 \n", + "3 0.691726 49.0 \n", + "4 0.411442 34.0 \n", + ".. ... ... \n", + "81 0.184155 51.0 \n", + "82 0.287113 58.0 \n", + "83 0.306071 42.0 \n", + "84 0.306070 44.0 \n", + "85 0.196725 47.0 \n", + "\n", + "[86 rows x 5 columns]" + ] + }, + "execution_count": 30, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "df = ea.dataframe()\n", + "df" + ] + }, + { + "cell_type": "code", + "execution_count": 31, + "id": "144cc4ef", + "metadata": {}, + "outputs": [ { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp35m19t1h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk6bsv741.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq_b2hzqz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzz9497ew.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvo8audyp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpizzi8tys.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfkn2v0x6.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz53umcfg.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx28_xdp9.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0olk_s94.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsazh3k83.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp34eqwmfb.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyflzmjhh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkb6pi9j2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpclw73kmc.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_9w4jmd7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk4mre91g.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplho1b2dj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8n_ojh3q.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpydcl60j9.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpubvykxut.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzbv2cj72.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpypggagp9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcnd6e3k2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt7mik6m6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptyffgkn6.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbk15q50v.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplgrmmcte.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpal8yopyu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, + "data": { + "image/png": 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\n", + "text/plain": [ + "
" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "ea.plot()" + ] + }, + { + "cell_type": "markdown", + "id": "a084f809", + "metadata": {}, + "source": [ + "We may even simulate one of the solution" + ] + }, + { + "cell_type": "code", + "execution_count": 32, + "id": "6a0f2afe", + "metadata": {}, + "outputs": [ { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3rj4816s.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp__xy77au.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqiztbz38.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnc_3752r.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5tq4ygw1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8vszw0p6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphpytb3i7.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp20x1hmdv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmtz7in2j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpol2r8_br.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6n6kgtvh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp72e9n72w.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk37v7lq0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpooat5wmm.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpot40p4ub.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphyx1lpsi.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpna7a2nea.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_fke8yk8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeu21g1zt.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz66hjutu.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6v5wyqqb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpox8f69wa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmiomgh7r.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0wenrcr0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4s7vqbje.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmvapm4e6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsdv_3npt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp04bu5rhj.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpleofecql.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqsek7mmv.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6f67635v.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl8xvom85.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5ahth942.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph47lzt7s.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwe5iddor.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc8_lxmo0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpayr2tumm.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6by6ree9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6mv1hqkw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmwmw8fig.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - " 400| 0.000000 0.411442 0.411442 0.372223 0.100871| 0.000000 0.411442 0.411442 0.372223 0.100871| 13.000000 42.000000 29.000000 26.920000 7.077683|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcbzcf69o.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu9ycdo0q.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyqqpnvib.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf39fwd2w.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdoz0qra3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiaq_67vp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmhrixw2d.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpweav4kx3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbt4lazkt.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7rz2a1le.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpy5xbns6p.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp837wyc9s.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3zed660u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzyx60d0e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqwcv1iyh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsmvw7vn3.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmcvwfa01.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8nkerh71.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbfdqllgg.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1azd9mkp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0n32ibf1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm78gd05t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_c6imumg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3rj0wmxu.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_5o40k6t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkpco6tqj.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5cv61r_w.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6o5u5cxr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxm56qsnc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa0qur1i7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpym4xm09u.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzg4e3r7c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0e8nl941.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq5ipkaph.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_cwy1aaj.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkegswugc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0kkw53_o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgqv884mr.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7phm2uxh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptesqes60.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfp4f_fu0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3klwc9as.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj012mx50.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3lcwvz6h.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt65oxgac.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7_am5mm_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj6jxcvqd.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpswxwtjgs.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp96fvrey5.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvp2319o3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgqulf_to.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwyiroy31.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcam22cee.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeivnqncd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv26ed48f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_dcui1vg.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5_ikcpjt.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps1xav1dq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbb3gh70p.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkdpx2_o6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr06dfkx8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_v0g0q0p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdd8perz4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprfbreeni.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6zfdv4ta.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxlthw9ct.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyu695aas.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1ea2316u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqyq4eez2.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw9qbjc8d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdc28kbbw.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwtijw398.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx25rk4_m.lp\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdrkicdp8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzhjxpoft.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuputnfuo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyczeew4t.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkunesv2y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp20fqj_8_.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm39yjwba.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbdzzcoh1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiciuvczh.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc2lzrzyr.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpotzfm1hd.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe5ztqmq1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoh3ts9ok.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqncxeijj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp149m9v7u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzabsme5m.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpix51jvs1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - " 500| 0.000000 0.411442 0.411442 0.375427 0.098954| 0.000000 0.411442 0.411442 0.375427 0.098954| 14.000000 42.000000 29.500000 28.130000 7.149343|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj2avbj1u.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe_5ymudl.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm3o393kv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu7nlm4q_.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnsvq01mu.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpuyr3qwbh.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8ca9masa.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Reading time = 0.01 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp68paxsyk.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzlg3xjps.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj2hxx5x6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptqqmnvbm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpoc_8u1cz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4fld2jn9.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjydyt996.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa1g8xtvk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4_x293x7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8ogao59o.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp92felvc2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp56aab8j.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfgy9mngc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm55ls2i9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq7ggihum.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6u51c30n.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxabyu6dy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyjsx5unz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv6839cvl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpypo3hkgs.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpka0m4o7m.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd5rfmz8l.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp30880vi4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp28lf3386.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1cnvksfc.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8svif72n.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwq_23dft.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkfh8z9mt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc5d_z0j_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgcib6lc4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeeit3iu1.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppbekxi7y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm99vgm5o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8iokwf93.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3qtr2ykk.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkfh_150u.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwv472rt9.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_jhp47_7.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe2bvvz1c.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp5wtq2ok.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0zokuceq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4_avox9b.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_ovorlfm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9msvcwc_.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmhnk9h1b.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx17rnu1e.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7c4auvtn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdzs_unb2.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpde9kc3ne.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj4jolh34.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdda_up64.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf84okx6a.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprmz87cvc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnz5n84ko.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplym742xr.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaem_ju0h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp47apdwm9.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8_f7c3rn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9eghwcxx.lp\n", - "Reading time = 0.01 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpndnwe0fp.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppay9pkid.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpivbryw84.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1lnwv1u1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaxmspmyt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2x3dngr9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpivdht54w.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj37kjx3a.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppuv3oqs6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqer105es.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpujqpfte4.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8pou_n1y.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvx249_9d.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz0vhqs_f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8c6expla.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7og5ta1e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxja4w7hu.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg08scg67.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnfx1xd7w.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5emj3vwu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpilv5xddc.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi34la_rj.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa5j_h77s.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprndgk0x7.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - " 600| 0.000000 0.411442 0.411442 0.371980 0.097123| 0.000000 0.411442 0.411442 0.371980 0.097123| 15.000000 45.000000 32.000000 30.310000 7.549430|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc5h9dgix.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx3ks43gj.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpupdej7kl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzlwuzmnh.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpev4pib9b.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0sgb0tco.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9dg9bs_8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm6nbwzir.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkyoi6vp_.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa0rp3grq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprwar_eh0.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgqbhc5a0.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo5ot29he.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphuc4t018.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8281ny9m.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwbdqmn7x.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5itl_892.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1pk4r614.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzjh53m6o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5va6rzdn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsr58efi7.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpapk0w7rq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpixs_r0b4.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1bxa9t68.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpptbxpp61.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdcm8f9n4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjqc2skpc.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp03se0e87.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqkumcddx.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphuymszhj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl5x15lqy.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpykg3dp24.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp70_0hdxl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbhsnfjsn.lp\n", - "Reading time = 0.00 seconds\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp42o7n8we.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_w_jmz8c.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9jnb71i1.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgr0cr2mn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmc7eonyh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxtoj8w05.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmputsirlc_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx880b09_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3mm624gk.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp60bv9_yj.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpprwr0qxt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcoyt0a5o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp74f7yaw7.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd2syof27.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm2rklai9.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkx1vbyxm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5mtwaee6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc872dr1p.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5y07ndpo.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpji5ktddo.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp57kycn_w.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7pe5ealz.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa46n7gg_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0o1bhkul.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1rpqgaax.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7aoeo192.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg4u8su2h.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkcl6t634.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6fav0pjb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpraff7ydk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9en12gfy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaztjbw1o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp22xx1f_w.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphlbt7hti.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyvrb3h96.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpojuwbo3w.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk2ml19wl.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcvh6wzb1.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjbcqokqk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphqbco7bv.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpujfixw70.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvi7sv553.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx5iga3zy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl0kf2gwl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvy_p188r.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptde_zyo5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv_2hxwww.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbntn645f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpmxswvl72.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu2sb3ibk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2naoz758.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkl8pk6u_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6h1f_p_6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkmk901az.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv676afvr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfh0am6p_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - " 700| 0.000000 0.411442 0.411442 0.369412 0.103833| 0.000000 0.411442 0.411442 0.369412 0.103833| 15.000000 53.000000 33.000000 32.160000 7.680781|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpscncnfue.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp25o8u655.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwv8z0jce.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpixzz_sl2.lp\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm23d40ll.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqsqgb_ex.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwib07m12.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_je_3jk5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptvb1rrxi.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv7pet6a_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpne3luobr.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp07wxc6n2.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjoqkhsjd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdxwhppkg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk8dncqjw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4eojhv3d.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp503e16q7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_yxg4oue.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4egj4d7_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwo_gp2xh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7s0p2eq6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprrs6z3b6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8zksmumj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm0nx2k0b.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_nn_k67d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpanvl0k11.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp26hpz76d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpptadoljd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqnv94dtj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn9vop2lb.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3p294vqd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkcc8iems.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkxlmlxvs.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp__irhvmr.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph46f7xfa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpibvw_2fb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp64iku3mn.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe2dhkaax.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcti6ldn9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2_ew6weh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1dy17oli.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9ypjyvfk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaf67kxqt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwosxm8t6.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkndt572b.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp10e0i47m.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprcrdvx6j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvxto3jwm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfdh0xje1.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyj48qrzy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_knigp98.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj_din2_v.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppo7h053d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqrkiq4n6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp1o61olm.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpscu4gsnn.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk1wrozne.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp40ge7rpu.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp030s8olv.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpka_6bogl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpyvddns2d.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_qglxw54.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplaz32ce5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl2arn3uc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1n9kim7t.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo96a37ax.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu9swbl65.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5on1qsru.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptl4acglw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2w8pv3vr.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9dxk9b9o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7pnmql5v.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqca69562.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6je8p7mk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjmjljy0c.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqbxj8ysf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_jb1kky3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpp9rbat2h.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplqlvbfn8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsadgcw4l.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6wj79weq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc7bs4x7q.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnx8b7sjp.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppiphe2bf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp05xj58a4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5sj_zycb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg6r8bfuo.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5xrectym.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8_i897ob.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplwgqkpc7.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - " 800| 0.000000 0.411442 0.411442 0.378349 0.093096| 0.000000 0.411442 0.411442 0.378349 0.093096| 16.000000 53.000000 34.000000 33.430000 7.634468|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpejhzh5l4.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz3azu8u7.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaxapmgq8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps2wajjeb.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvoueli85.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpf_fag1s2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_blo37t1.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp59uwpxan.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpqaf5it31.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp2k4tkops.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd5yd5_dq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk7jvp0fq.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpshhuatza.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr_l2o22t.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1lqc2s8s.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk3ta9tl7.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbxo42k73.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpn4gnilhp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjjn23tti.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeaalqe00.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeanpoxil.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1nt0wli1.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiffgn6hu.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvcx6is48.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsadz2wkk.lp\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfc5hkqb0.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpypo0prna.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm8ythk8x.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdhzxqh9o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpysl08vdk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpugtmddbj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_v056zjd.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp01lbrn3f.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxs04voof.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3p6h7mvy.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpez_bztxa.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnhkbh63f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsuvydsdt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgc36j9ny.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd3_oz66x.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppd0hj2q4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa4nncrhi.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpiz3aqzg_.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpye814rmm.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw1wu7t0x.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa1wwi827.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpok9gl_gt.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnlgkxjn4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpkpnsgkzf.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzu9to5ki.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfiw0odh3.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6vi4yt05.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplym81zso.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjuxxiy0p.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3u8vsxyy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxrqpwqhi.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8r2y06p0.lp\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpnrweh8i1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1jk6e9sn.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpr8hoki_1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpisdwqihw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5yckj3x6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9vs4u6nd.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpifpdcwce.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpwzrs8jze.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0qsopp1o.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpps7sm8rp.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgetu4fn2.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg2bk2zc4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpie2dqnlt.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp58del27b.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7vi001il.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphf55qwc4.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpudulehgr.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo3ne67sv.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3hggwxee.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpq8uwxzm4.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4dxwa3pd.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgtz0jzsb.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps4y2677r.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjz91wvhz.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpe0xbkt1d.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgixhnofy.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp63vhc7ym.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpa66jim38.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphjxk1gzl.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzpuf_tsu.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp3pati8da.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaqxgp6e0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpt88xdmw3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - " 900| 0.000000 0.411442 0.411442 0.376840 0.097715| 0.000000 0.411442 0.411442 0.376840 0.097715| 16.000000 53.000000 34.500000 33.700000 8.066598|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptt1okthp.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpx_hki7ev.lp\n", - "Reading time = 0.01 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpj416n_h0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpu_si6nfp.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_nktkutk.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl4bar3ud.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpg621b0at.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplaiebbvp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplc1hjnwj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk4nxstp0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5ci1073p.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpppcvqtb5.lp\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm592neuq.lp\n", - "Reading time = 0.00 seconds\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpojx409rx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp94nhmsg5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprxcsw3m3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8cq5lep6.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpdb6hxd95.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmppgchm8go.lp\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Reading time = 0.00 seconds\n", - "Set parameter OptimalityTol to value 1e-09\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjv8buunj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp6p6hv3aj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7kcv1o7q.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp78xk87q3.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpin0ehl17.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7b01_ja4.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0stww3k6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp29xevh0a.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_owg3dmp.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpb0oqsulv.lp\n", - "Reading time = 0.01 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp81shxvik.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprpu13dio.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpldep2bp6.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmprem0y9ut.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpo9umgrby.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpsc5kmf_9.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp4u_gjgxx.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp60kj9ru_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0sonaae0.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_4jddwxw.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi8qsku1u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc37ag46k.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpaan2z4ae.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7vav1v5e.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpjn3_kymc.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpxwrwtdhg.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpgjxsu24t.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpfr8d7io5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpv1mv3l0k.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbgb6_mg0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpw9boj5xc.lp\n", - "Reading time = 0.00 seconds\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpacz3m5df.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpl2om3x1j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp54p_xrze.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9936ro4q.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpcuxzpa3f.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc17l6zfh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpi613smwz.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp40ua3uj_.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpzci1eiri.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp65wgzyfq.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp08g6prom.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpidomcxu5.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpilew7ye8.lp\n", - "Reading time = 0.00 seconds\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpvns4i9u0.lp\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp1iz25arb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpd50y7r9c.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp18w6x25c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp9syyw1kj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpct43l26c.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpz8cag_kj.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpae___49u.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpeiqwmldb.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp32phg6jj.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptmjpi99e.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpk5euvfh0.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp30342190.lp\n", - "Reading time = 0.00 seconds\n", - "Set parameter FeasibilityTol to value 1e-09\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp5v8ikadw.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmplu5l8ll2.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmph6onngp0.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpryfnftss.lp\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpbq1bfcla.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmphcbf7aon.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp0noh703_.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpm01dmmty.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp8p_z6h57.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmptcjg9_gk.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp_s9e3rg1.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmps585feog.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7ouq5aw8.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp14qxkq2j.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - " 1000| 0.000000 0.411442 0.411442 0.369255 0.110392| 0.000000 0.411442 0.411442 0.369255 0.110392| 16.000000 53.000000 35.000000 34.310000 9.106805|\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmp7692z6mn.lp\n", - "Reading time = 0.00 seconds\n", - ": 166 rows, 426 columns, 1572 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpc9821dec.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Read LP format model from file /var/folders/fw/kbs61_l15j587pjbwf3_y8780000gn/T/tmpei1st5eh.lp\n", - "Reading time = 0.00 seconds\n", - ": 72 rows, 190 columns, 720 nonzeros\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - 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"Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n" - ] - }, - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n", - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] + "data": { + "text/plain": [ + "[0.293004792691598, 0.46175823055628923, 44.0];{'b0978_ec1': 0, 'b2282_ec1': 0, 'b0755_ec2': 0, 'b2296_ec2': 0, 'b3403_ec2': 0, 'b0723_ec1': 0, 'b0726_ec1': 0, 'b0721_ec2': 0, 'b1612_ec2': 0, 'b1101_ec1': 0, 'b2297_ec2': 0, 'b4122_ec1': 0, 'b4014_ec1': 0, 'b1478_ec1': 0, 'b2463_ec2': 0, 'b3114_ec1': 0, 'b2284_ec1': 0, 'b2579_ec1': 0, 'b3870_ec1': 0, 'b0727_ec1': 0, 'b3870_ec2': 0, 'b2465_ec2': 0, 'b4151_ec1': 0, 'b3739_ec2': 0, 'b3951_ec2': 0, 'b0755_ec1': 0, 'b2283_ec1': 0, 'b0721_ec1': 0, 'b0723_ec2': 0, 'b1854_ec2': 0, 'b0810_ec1': 0, 'b1241_ec2': 0, 'b1817_ec2': 0, 'b0811_ec2': 0, 'b3962_ec2': 0, 'b1479_ec1': 0, 'b1478_ec2': 0, 'b0474_ec1': 0, 'b1819_ec2': 0, 'b1819_ec1': 0, 'b2464_ec2': 0, 'b3114_ec2': 0, 'b1818_ec2': 0, 'b1852_ec2': 0}" + ] + }, + "execution_count": 32, + "metadata": {}, + "output_type": "execute_result" } ], "source": [ - "from mewpy.util.constants import EAConstants\n", - "EAConstants.DEBUG = True\n", - "\n", - "ea = EA(problem,\n", - " max_generations=10,\n", - " initial_population=init_pop[:100])\n", - "\n", - "solutions = ea.run(simplify=False)" - ] - }, - { - "cell_type": "markdown", - "id": "aa16fe03", - "metadata": {}, - "source": [ - "We may now have a look at the solutions as a dataframe or as a plot" + "solution = solutions[5]\n", + "solution" ] }, { "cell_type": "code", - "execution_count": 25, - "id": "cf72f00d", + "execution_count": 38, + "id": "9c1fc9ed-ad8a-44ab-b48a-f314db521dee", "metadata": {}, "outputs": [ { @@ -11750,212 +1082,61 @@ " \n", " \n", " \n", - " Modification\n", - " Size\n", - " TargetFlux\n", - " TargetFlux\n", - " Size\n", - " \n", - " \n", - " \n", - " \n", - " 0\n", - " {'b0734_ec2': 0, 'b2465_ec2': 0, 'b4122_ec2': ...\n", - " 33\n", - " 0.411442\n", - " 0.411442\n", - " 33\n", - " \n", - " \n", - " 1\n", - " {'b0734_ec2': 0, 'b1773_ec2': 0, 'b0474_ec2': ...\n", - " 24\n", - " 0.411442\n", - " 0.411442\n", - " 24\n", - " \n", - " \n", - " 2\n", - " {'b4015_ec2': 0, 'b4122_ec2': 0, 'b1773_ec2': ...\n", - " 53\n", - " 0.000000\n", - " 0.000000\n", - " 53\n", - " \n", - " \n", - " 3\n", - " {'b0734_ec2': 0, 'b4122_ec2': 0, 'b0978_ec2': ...\n", - " 46\n", - " 0.356076\n", - " 0.356076\n", - " 46\n", - " \n", - " \n", - " 4\n", - " {'b4015_ec2': 0, 'b0978_ec2': 0, 'b2579_ec2': ...\n", - " 44\n", - " 0.407275\n", - " 0.407275\n", - " 44\n", - " \n", - " \n", - " ...\n", - " ...\n", - " ...\n", - " ...\n", - " ...\n", - " ...\n", - " \n", - " \n", - " 61\n", - " {'b0734_ec2': 0, 'b2465_ec2': 0, 'b4122_ec2': ...\n", - " 32\n", - " 0.411442\n", - " 0.411442\n", - " 32\n", + " Flux rate\n", " \n", " \n", - " 62\n", - " {'b0734_ec2': 0, 'b2465_ec2': 0, 'b4122_ec2': ...\n", - " 36\n", - " 0.411442\n", - " 0.411442\n", - " 36\n", + " Reaction ID\n", + " \n", " \n", + " \n", + " \n", " \n", - " 63\n", - " {'b0734_ec2': 0, 'b4015_ec2': 0, 'b4122_ec2': ...\n", - " 32\n", - " 0.411442\n", - " 0.411442\n", - " 32\n", + " BIOMASS_Ecoli_core_w_GAM_ec1\n", + " 0.151643\n", " \n", " \n", - " 64\n", - " {'b0734_ec2': 0, 'b2465_ec2': 0, 'b4122_ec2': ...\n", - " 34\n", - " 0.411442\n", - " 0.411442\n", - " 34\n", + " BIOMASS_Ecoli_core_w_GAM_ec2\n", + " 0.610744\n", " \n", " \n", - " 65\n", - " {'b0734_ec2': 0, 'b2465_ec2': 0, 'b0978_ec2': ...\n", - " 34\n", - " 0.411442\n", - " 0.411442\n", - " 34\n", + " community_growth\n", + " 0.762387\n", " \n", " \n", "\n", - "

66 rows × 5 columns

\n", "" ], "text/plain": [ - " Modification Size TargetFlux \\\n", - "0 {'b0734_ec2': 0, 'b2465_ec2': 0, 'b4122_ec2': ... 33 0.411442 \n", - "1 {'b0734_ec2': 0, 'b1773_ec2': 0, 'b0474_ec2': ... 24 0.411442 \n", - "2 {'b4015_ec2': 0, 'b4122_ec2': 0, 'b1773_ec2': ... 53 0.000000 \n", - "3 {'b0734_ec2': 0, 'b4122_ec2': 0, 'b0978_ec2': ... 46 0.356076 \n", - "4 {'b4015_ec2': 0, 'b0978_ec2': 0, 'b2579_ec2': ... 44 0.407275 \n", - ".. ... ... ... \n", - "61 {'b0734_ec2': 0, 'b2465_ec2': 0, 'b4122_ec2': ... 32 0.411442 \n", - "62 {'b0734_ec2': 0, 'b2465_ec2': 0, 'b4122_ec2': ... 36 0.411442 \n", - "63 {'b0734_ec2': 0, 'b4015_ec2': 0, 'b4122_ec2': ... 32 0.411442 \n", - "64 {'b0734_ec2': 0, 'b2465_ec2': 0, 'b4122_ec2': ... 34 0.411442 \n", - "65 {'b0734_ec2': 0, 'b2465_ec2': 0, 'b0978_ec2': ... 34 0.411442 \n", - "\n", - " TargetFlux Size \n", - "0 0.411442 33 \n", - "1 0.411442 24 \n", - "2 0.000000 53 \n", - "3 0.356076 46 \n", - "4 0.407275 44 \n", - ".. ... ... \n", - "61 0.411442 32 \n", - "62 0.411442 36 \n", - "63 0.411442 32 \n", - "64 0.411442 34 \n", - "65 0.411442 34 \n", - "\n", - "[66 rows x 5 columns]" + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_ec1 0.151643\n", + "BIOMASS_Ecoli_core_w_GAM_ec2 0.610744\n", + "community_growth 0.762387" ] }, - "execution_count": 25, + "execution_count": 38, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "df = ea.dataframe()\n", - "df" - ] - }, - { - "cell_type": "code", - "execution_count": 26, - "id": "144cc4ef", - "metadata": {}, - "outputs": [ - { - "data": { - "image/png": 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" - ] - }, - "metadata": {}, - "output_type": "display_data" - } - ], - "source": [ - "ea.plot()" + "problem.simulate(solution=solution.values,method='FBA').find('BIOMASS|growth',show_nulls=True)" ] }, { "cell_type": "markdown", - "id": "a084f809", + "id": "1983ab2b-4143-4362-9e89-55e2c5ddd60e", "metadata": {}, "source": [ - "We may even simulate one of the solution" + "The previous FBA solution is one of many that results from the genes deletion. We can select one particular solution by considering some assumption such as the difference between the organisms growth is minimized while keeping the same community growth: " ] }, { "cell_type": "code", - "execution_count": 27, - "id": "6a0f2afe", - "metadata": {}, - "outputs": [ - { - "data": { - "text/plain": [ - "[0.41144179768074646, 0.41144179766115907, 35];{'b0734_ec2': 0, 'b2465_ec2': 0, 'b4122_ec2': 0, 'b4153_ec1': 0, 'b0474_ec2': 0, 'b0978_ec2': 0, 'b0733_ec2': 0, 'b2976_ec2': 0, 'b0811_ec2': 0, 'b0809_ec2': 0, 'b4154_ec2': 0, 'b0903_ec2': 0, 'b2297_ec2': 0, 'b1297_ec2': 0, 'b0721_ec2': 0, 'b0724_ec2': 0, 'b1812_ec2': 0, 'b1479_ec2': 0, 'b3386_ec2': 0, 'b1849_ec2': 0, 'b0755_ec2': 0, 'b0767_ec2': 0, 'b2276_ec2': 0, 'b1478_ec2': 0, 'b0114_ec2': 0, 'b3115_ec2': 0, 'b1611_ec2': 0, 'b2097_ec2': 0, 'b2288_ec2': 0, 'b0116_ec2': 0, 'b1276_ec2': 0, 'b1702_ec2': 0, 'b1101_ec2': 0, 'b3735_ec2': 0, 'b3736_ec2': 0}" - ] - }, - "execution_count": 27, - "metadata": {}, - "output_type": "execute_result" - } - ], - "source": [ - "solution = solutions[5]\n", - "solution" - ] - }, - { - "cell_type": "code", - "execution_count": 28, + "execution_count": 43, "id": "d0efbd3c", "metadata": {}, "outputs": [ - { - "name": "stdout", - "output_type": "stream", - "text": [ - "Set parameter FeasibilityTol to value 1e-09\n", - "Set parameter OptimalityTol to value 1e-09\n" - ] - }, { "data": { "text/html": [ @@ -11987,11 +1168,15 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec1\n", - " 0.411442\n", + " 0.293005\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec2\n", - " 0.411442\n", + " 0.461758\n", + " \n", + " \n", + " community_growth\n", + " 0.754763\n", " \n", " \n", "\n", @@ -12000,64 +1185,108 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_ec1 0.411442\n", - "BIOMASS_Ecoli_core_w_GAM_ec2 0.411442" + "BIOMASS_Ecoli_core_w_GAM_ec1 0.293005\n", + "BIOMASS_Ecoli_core_w_GAM_ec2 0.461758\n", + "community_growth 0.754763" ] }, - "execution_count": 28, + "execution_count": 43, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "problem.simulate(solution=solution.values,method=regComFBA).find('BIOMASS',show_nulls=True)" + "problem.simulate(solution=solution.values,method=regComFBA).find('BIOMASS|growth',show_nulls=True)" ] }, { "cell_type": "markdown", - "id": "2787a893", + "id": "d5eef1f2-3cc6-4359-a4dc-20451061b94f", "metadata": {}, "source": [ - "or have a look to the reactions that were 'deleted'" + "We may also relax on the community growth to 90% of confidence by setting `obj_frac=0.9` (by default this value is set to 0.99):" ] }, { "cell_type": "code", - "execution_count": 29, - "id": "c92e07da", + "execution_count": 44, + "id": "19e526f3-e152-4164-a740-b53fa520172e", "metadata": {}, "outputs": [ { "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_ec10.343074
BIOMASS_Ecoli_core_w_GAM_ec20.343074
community_growth0.686148
\n", + "
" + ], "text/plain": [ - "{'PDH_ec2': 0,\n", - " 'ME1_ec2': 0,\n", - " 'ATPS4r_ec2': 0,\n", - " 'NADH16_ec2': 0,\n", - " 'PGL_ec2': 0,\n", - " 'AKGDH_ec2': 0,\n", - " 'FRD7_ec2': 0,\n", - " 'FRD7_ec1': 0,\n", - " 'ADK1_ec2': 0,\n", - " 'SUCDi_ec2': 0,\n", - " 'CYTBD_ec2': 0,\n", - " 'PPS_ec2': 0,\n", - " 'GLNabc_ec2': 0}" + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_ec1 0.343074\n", + "BIOMASS_Ecoli_core_w_GAM_ec2 0.343074\n", + "community_growth 0.686148" ] }, - "execution_count": 29, + "execution_count": 44, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "problem.solution_to_constraints(solution.values)" + "problem.simulate(solution=solution.values,method=regComFBA, obj_frac=0.9).find('BIOMASS|growth',show_nulls=True)" + ] + }, + { + "cell_type": "markdown", + "id": "e8055fce-3084-4fd8-b7d9-75ba2e4fb7df", + "metadata": {}, + "source": [ + "Other FBA methods can be used such as parsimonious FBA:" ] }, { "cell_type": "code", - "execution_count": 30, - "id": "0ba1823b", + "execution_count": 45, + "id": "71d388c4-d81d-47ce-b191-57ad12541ced", "metadata": {}, "outputs": [ { @@ -12091,11 +1320,15 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec1\n", - " 0.415598\n", + " 0.000000\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec2\n", - " 0.415598\n", + " 0.762387\n", + " \n", + " \n", + " community_growth\n", + " 0.762387\n", " \n", " \n", "\n", @@ -12104,17 +1337,60 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_ec1 0.415598\n", - "BIOMASS_Ecoli_core_w_GAM_ec2 0.415598" + "BIOMASS_Ecoli_core_w_GAM_ec1 0.000000\n", + "BIOMASS_Ecoli_core_w_GAM_ec2 0.762387\n", + "community_growth 0.762387" ] }, - "execution_count": 30, + "execution_count": 45, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "problem.simulate(solution=solution.values,method='pFBA').find('BIOMASS',show_nulls=True)" + "problem.simulate(solution=solution.values,method='pFBA').find('BIOMASS|growth',show_nulls=True)" + ] + }, + { + "cell_type": "markdown", + "id": "2787a893", + "metadata": {}, + "source": [ + "Me may also have a look to the reactions that were 'deleted'" + ] + }, + { + "cell_type": "code", + "execution_count": 34, + "id": "c92e07da", + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'SUCDi_ec2': 0,\n", + " 'FRUpts2_ec2': 0,\n", + " 'PPCK_ec2': 0,\n", + " 'AKGDH_ec1': 0,\n", + " 'SUCDi_ec1': 0,\n", + " 'ME1_ec1': 0,\n", + " 'ADK1_ec1': 0,\n", + " 'G6PDH2r_ec2': 0,\n", + " 'GLNabc_ec2': 0,\n", + " 'FRUpts2_ec1': 0,\n", + " 'NADH16_ec1': 0,\n", + " 'FRD7_ec1': 0,\n", + " 'ME2_ec2': 0,\n", + " 'GLNabc_ec1': 0}" + ] + }, + "execution_count": 34, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "problem.solution_to_constraints(solution.values)" ] }, { From c4f94f169a7862a4b16ac58ada1ecd0aa36b76ed Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 29 Jun 2024 13:31:34 +0100 Subject: [PATCH 08/24] Update notebooks --- examples/08-community.ipynb | 710 ++++++++++++++++++++----------- examples/09-crossfeeding.ipynb | 754 +++++++++++++++++++++------------ 2 files changed, 956 insertions(+), 508 deletions(-) diff --git a/examples/08-community.ipynb b/examples/08-community.ipynb index f6da42d8..4252dde4 100644 --- a/examples/08-community.ipynb +++ b/examples/08-community.ipynb @@ -56,8 +56,8 @@ "name": "stdout", "output_type": "stream", "text": [ - "MEWpy version: 0.1.35\n", - "Author: Vitor Pereira and CEB University of Minho (2019-2023)\n", + "MEWpy version: 0.1.36\n", + "Author: Vitor Pereira (2019-) and CEB University of Minho (2019-2023)\n", "Contact: vpereira@ceb.uminho.pt \n", "\n", "Available LP solvers: gurobi cplex glpk\n", @@ -85,7 +85,18 @@ "id": "6f2de219", "metadata": {}, "source": [ - "**IMPORTANT**: The notebook requires a MEWpy version >= 0.1.35" + "**IMPORTANT**: The notebook requires a MEWpy version >= 0.1.36" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "58242ec0", + "metadata": {}, + "outputs": [], + "source": [ + "import pandas as pd\n", + "pd.set_option('display.max_columns', None)" ] }, { @@ -100,7 +111,7 @@ }, { "cell_type": "code", - "execution_count": 3, + "execution_count": 4, "id": "70b7be89", "metadata": {}, "outputs": [], @@ -112,7 +123,7 @@ }, { "cell_type": "code", - "execution_count": 4, + "execution_count": 5, "id": "938ae881", "metadata": {}, "outputs": [], @@ -144,7 +155,7 @@ }, { "cell_type": "code", - "execution_count": 5, + "execution_count": 6, "id": "4fd366fe", "metadata": {}, "outputs": [ @@ -232,7 +243,7 @@ "EX_pi_e -3.214895" ] }, - "execution_count": 5, + "execution_count": 6, "metadata": {}, "output_type": "execute_result" } @@ -258,7 +269,7 @@ }, { "cell_type": "code", - "execution_count": 6, + "execution_count": 7, "id": "196680b4", "metadata": {}, "outputs": [], @@ -270,7 +281,7 @@ }, { "cell_type": "code", - "execution_count": 7, + "execution_count": 8, "id": "baeb1a1d", "metadata": {}, "outputs": [], @@ -292,7 +303,7 @@ }, { "cell_type": "code", - "execution_count": 8, + "execution_count": 9, "id": "b6e5ff2a", "metadata": {}, "outputs": [], @@ -303,7 +314,7 @@ }, { "cell_type": "code", - "execution_count": 9, + "execution_count": 10, "id": "f766d344", "metadata": {}, "outputs": [ @@ -353,7 +364,7 @@ "nh4_ko 1.0 1.0" ] }, - "execution_count": 9, + "execution_count": 10, "metadata": {}, "output_type": "execute_result" } @@ -364,7 +375,7 @@ }, { "cell_type": "code", - "execution_count": 10, + "execution_count": 11, "id": "aa208246", "metadata": {}, "outputs": [ @@ -414,7 +425,7 @@ "nh4_ko 0.978947 1.000000" ] }, - "execution_count": 10, + "execution_count": 11, "metadata": {}, "output_type": "execute_result" } @@ -425,7 +436,7 @@ }, { "cell_type": "code", - "execution_count": 11, + "execution_count": 12, "id": "2e6e97cb", "metadata": {}, "outputs": [ @@ -475,7 +486,7 @@ "nh4_ko 1.0 1.0" ] }, - "execution_count": 11, + "execution_count": 12, "metadata": {}, "output_type": "execute_result" } @@ -496,7 +507,7 @@ }, { "cell_type": "code", - "execution_count": 46, + "execution_count": 13, "id": "91e413e9", "metadata": {}, "outputs": [], @@ -505,9 +516,28 @@ "community = CommunityModel([glc_ko, nh4_ko], merge_biomasses=False, flavor='cobra')" ] }, + { + "cell_type": "markdown", + "id": "6aab14c3", + "metadata": {}, + "source": [ + "Arguments:\n", + "- `merge_biomasses=False`: The model does not assume a relative abundance of organisms in the community. If set to `True`, a default abundance of 1:1 would be assumed.\n", + "- `flavor='cobra'`: The model is built over the 'Cobra' framework. `reframed` is an alternative option which is faster for large communities. \n", + "\n", + "Additional optional arguments:\n", + "\n", + "- `abundances`: A list of relative abundances for each model (use the same order of the models), e.g, `abundances=[1,2]`. \n", + " \n", + "- `add_compartments`: If each organism external compartment is to be added to the community model. Default `True`.\n", + "- `balance_exchanges`: If the organisms uptakes should reflect their abundances. This will normalize each organism flux value in acordance to the abundance. Default `True`. \n", + "- `copy_models`: if the models are to be copied, default `True`.\n", + " " + ] + }, { "cell_type": "code", - "execution_count": 47, + "execution_count": 14, "id": "46ed57b9", "metadata": {}, "outputs": [ @@ -515,7 +545,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.32it/s]\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.69it/s]\n" ] } ], @@ -535,7 +565,7 @@ }, { "cell_type": "code", - "execution_count": 48, + "execution_count": 15, "id": "6644486c", "metadata": {}, "outputs": [ @@ -677,7 +707,7 @@ "EX_succ_e\t0.0\t1000.0" ] }, - "execution_count": 48, + "execution_count": 15, "metadata": {}, "output_type": "execute_result" } @@ -700,7 +730,7 @@ }, { "cell_type": "code", - "execution_count": 49, + "execution_count": 16, "id": "47cb7a4b", "metadata": {}, "outputs": [ @@ -881,7 +911,7 @@ "EX_co2_e 24.628058" ] }, - "execution_count": 49, + "execution_count": 16, "metadata": {}, "output_type": "execute_result" } @@ -907,7 +937,7 @@ }, { "cell_type": "code", - "execution_count": 50, + "execution_count": 17, "id": "0b5d171f", "metadata": {}, "outputs": [ @@ -959,7 +989,7 @@ "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.831196" ] }, - "execution_count": 50, + "execution_count": 17, "metadata": {}, "output_type": "execute_result" } @@ -978,7 +1008,7 @@ }, { "cell_type": "code", - "execution_count": 51, + "execution_count": 18, "id": "960e9b0b", "metadata": {}, "outputs": [ @@ -1104,7 +1134,7 @@ "[165 rows x 3 columns]" ] }, - "execution_count": 51, + "execution_count": 18, "metadata": {}, "output_type": "execute_result" } @@ -1115,7 +1145,7 @@ }, { "cell_type": "code", - "execution_count": 72, + "execution_count": 19, "id": "a69cf655", "metadata": {}, "outputs": [ @@ -1150,35 +1180,35 @@ " \n", " \n", " ACALD_glc_ko\n", - " 7.810667\n", + " -1.602163\n", " \n", " \n", - " ACALDt_glc_ko\n", - " 0.288725\n", + " ACKr_glc_ko\n", + " 6.134506\n", " \n", " \n", " ACONTa_glc_ko\n", - " 6.283168\n", + " 4.532343\n", " \n", " \n", " ACONTb_glc_ko\n", - " 6.283168\n", + " 4.532343\n", " \n", " \n", - " ADK1_glc_ko\n", - " 1.904747\n", + " ACt2r_glc_ko\n", + " 6.134506\n", " \n", " \n", " AKGDH_glc_ko\n", - " 7.011377\n", + " 4.532343\n", " \n", " \n", " AKGt2r_glc_ko\n", - " 3.390348\n", + " 4.532343\n", " \n", " \n", " ALCD2x_glc_ko\n", - " 7.521941\n", + " -1.602163\n", " \n", " \n", " ATPM_glc_ko\n", @@ -1186,259 +1216,364 @@ " \n", " \n", " ATPS4r_glc_ko\n", - " 30.752670\n", - " \n", - " \n", - " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 0.407572\n", + " 9.992163\n", " \n", " \n", " CO2t_glc_ko\n", - " -13.294545\n", + " -9.064686\n", " \n", " \n", " CS_glc_ko\n", - " 6.283168\n", + " 4.532343\n", " \n", " \n", " CYTBD_glc_ko\n", - " 33.361706\n", + " 10.392704\n", " \n", " \n", - " ENO_glc_ko\n", - " -1.693177\n", + " ETOHt2r_glc_ko\n", + " -1.602163\n", " \n", " \n", - " ETOHt2r_glc_ko\n", - " 7.521941\n", + " EX_ac_e_glc_ko\n", + " -6.134506\n", + " \n", + " \n", + " EX_akg_e_glc_ko\n", + " -4.532343\n", + " \n", + " \n", + " EX_co2_e_glc_ko\n", + " 9.064686\n", " \n", " \n", - " FBA_glc_ko\n", - " -0.405412\n", + " EX_etoh_e_glc_ko\n", + " 1.602163\n", " \n", " \n", - " FBP_glc_ko\n", - " 0.405412\n", + " EX_glu__L_e_glc_ko\n", + " 4.532343\n", " \n", " \n", - " FUM_glc_ko\n", - " 7.011377\n", + " EX_h_e_glc_ko\n", + " -6.134506\n", + " \n", + " \n", + " EX_h2o_e_glc_ko\n", + " 7.462523\n", " \n", " \n", - " GAPD_glc_ko\n", - " -1.083449\n", + " EX_nh4_e_glc_ko\n", + " -4.532343\n", " \n", " \n", - " GLNS_glc_ko\n", - " 0.104216\n", + " EX_o2_e_glc_ko\n", + " -5.196352\n", + " \n", + " \n", + " FUM_glc_ko\n", + " 4.532343\n", " \n", " \n", " GLUDy_glc_ko\n", - " -4.340602\n", + " -4.532343\n", " \n", " \n", " GLUt2r_glc_ko\n", - " -2.222409\n", + " -4.532343\n", " \n", " \n", " H2Ot_glc_ko\n", - " -18.390210\n", + " -7.462523\n", " \n", " \n", " ICDHyr_glc_ko\n", - " 6.283168\n", + " 4.532343\n", " \n", " \n", " MDH_glc_ko\n", - " 7.011377\n", + " 4.532343\n", " \n", " \n", " NADH16_glc_ko\n", - " 26.350329\n", + " 5.860360\n", " \n", " \n", " NH4t_glc_ko\n", - " 4.444818\n", + " 4.532343\n", " \n", " \n", " O2t_glc_ko\n", - " 16.680853\n", - " \n", - " \n", - " PGI_glc_ko\n", - " -0.083552\n", + " 5.196352\n", " \n", " \n", - " PGK_glc_ko\n", - " 1.083449\n", + " PTAr_glc_ko\n", + " -6.134506\n", " \n", " \n", - " PGM_glc_ko\n", - " 1.693177\n", + " SUCDi_glc_ko\n", + " 4.532343\n", " \n", " \n", - " PIt2r_glc_ko\n", - " 1.499335\n", + " SUCOAS_glc_ko\n", + " -4.532343\n", " \n", - " \n", - " PPS_glc_ko\n", - " 1.904747\n", + " \n", + "\n", + "" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "ACALD_glc_ko -1.602163\n", + "ACKr_glc_ko 6.134506\n", + "ACONTa_glc_ko 4.532343\n", + "ACONTb_glc_ko 4.532343\n", + "ACt2r_glc_ko 6.134506\n", + "AKGDH_glc_ko 4.532343\n", + "AKGt2r_glc_ko 4.532343\n", + "ALCD2x_glc_ko -1.602163\n", + "ATPM_glc_ko 8.390000\n", + "ATPS4r_glc_ko 9.992163\n", + "CO2t_glc_ko -9.064686\n", + "CS_glc_ko 4.532343\n", + "CYTBD_glc_ko 10.392704\n", + "ETOHt2r_glc_ko -1.602163\n", + "EX_ac_e_glc_ko -6.134506\n", + "EX_akg_e_glc_ko -4.532343\n", + "EX_co2_e_glc_ko 9.064686\n", + "EX_etoh_e_glc_ko 1.602163\n", + "EX_glu__L_e_glc_ko 4.532343\n", + "EX_h_e_glc_ko -6.134506\n", + "EX_h2o_e_glc_ko 7.462523\n", + "EX_nh4_e_glc_ko -4.532343\n", + "EX_o2_e_glc_ko -5.196352\n", + "FUM_glc_ko 4.532343\n", + "GLUDy_glc_ko -4.532343\n", + "GLUt2r_glc_ko -4.532343\n", + "H2Ot_glc_ko -7.462523\n", + "ICDHyr_glc_ko 4.532343\n", + "MDH_glc_ko 4.532343\n", + "NADH16_glc_ko 5.860360\n", + "NH4t_glc_ko 4.532343\n", + "O2t_glc_ko 5.196352\n", + "PTAr_glc_ko -6.134506\n", + "SUCDi_glc_ko 4.532343\n", + "SUCOAS_glc_ko -4.532343" + ] + }, + "execution_count": 19, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "solution.find('glc_ko')" + ] + }, + { + "cell_type": "markdown", + "id": "b7b12343", + "metadata": {}, + "source": [ + "We can look at the organisms' exchanges with the environment" + ] + }, + { + "cell_type": "code", + "execution_count": 20, + "id": "12bcf5cc", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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glc_konh4_koTotal
PYRt2_glc_ko3.059318Metabolite
RPE_glc_ko-0.292963glc__D_e0.000000-10.000000-10.00000
RPI_glc_ko-0.292963gln__L_e0.0000000.0000000.00000
SUCDi_glc_ko7.011377glu__L_e4.532343-4.5323430.00000
SUCOAS_glc_ko-7.011377h2o_e7.46252323.22029530.68282
TALA_glc_ko-0.072915h_e-6.13450622.80828916.67378
THD2_glc_ko3.367243lac__D_e0.0000000.0000000.00000
TKT1_glc_ko-0.072915mal__L_e0.0000000.0000000.00000
TKT2_glc_ko-0.220048nh4_e-4.5323430.000000-4.53234
TPI_glc_ko-0.405412o2_e-5.196352-18.470761-23.66711
EX_glu__L_e_glc_ko2.222409pi_e0.000000-3.057719-3.05772
EX_h2o_e_glc_ko18.390210pyr_e0.0000000.0000000.00000
EX_h_e_glc_ko2.780701ac_e-6.1345066.1345060.00000
EX_nh4_e_glc_ko-4.444818acald_e0.0000000.0000000.00000
EX_o2_e_glc_ko-16.680853succ_e0.0000000.0000000.00000
EX_pi_e_glc_ko-1.499335akg_e-4.5323434.5323430.00000
EX_pyr_e_glc_ko-3.059318co2_e9.06468615.56337224.62806
EX_acald_e_glc_ko-0.288725etoh_e1.602163-1.6021630.00000
EX_akg_e_glc_ko-3.390348for_e0.0000000.0000000.00000
EX_co2_e_glc_ko13.294545fru_e0.0000000.0000000.00000
EX_etoh_e_glc_ko-7.521941fum_e0.0000000.0000000.00000
\n", "
" ], "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "ACALD_glc_ko 7.810667\n", - "ACALDt_glc_ko 0.288725\n", - "ACONTa_glc_ko 6.283168\n", - "ACONTb_glc_ko 6.283168\n", - "ADK1_glc_ko 1.904747\n", - "AKGDH_glc_ko 7.011377\n", - "AKGt2r_glc_ko 3.390348\n", - "ALCD2x_glc_ko 7.521941\n", - "ATPM_glc_ko 8.390000\n", - "ATPS4r_glc_ko 30.752670\n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.407572\n", - "CO2t_glc_ko -13.294545\n", - "CS_glc_ko 6.283168\n", - "CYTBD_glc_ko 33.361706\n", - "ENO_glc_ko -1.693177\n", - "ETOHt2r_glc_ko 7.521941\n", - "FBA_glc_ko -0.405412\n", - "FBP_glc_ko 0.405412\n", - "FUM_glc_ko 7.011377\n", - "GAPD_glc_ko -1.083449\n", - "GLNS_glc_ko 0.104216\n", - "GLUDy_glc_ko -4.340602\n", - "GLUt2r_glc_ko -2.222409\n", - "H2Ot_glc_ko -18.390210\n", - "ICDHyr_glc_ko 6.283168\n", - "MDH_glc_ko 7.011377\n", - "NADH16_glc_ko 26.350329\n", - "NH4t_glc_ko 4.444818\n", - "O2t_glc_ko 16.680853\n", - "PGI_glc_ko -0.083552\n", - "PGK_glc_ko 1.083449\n", - "PGM_glc_ko 1.693177\n", - "PIt2r_glc_ko 1.499335\n", - "PPS_glc_ko 1.904747\n", - "PYRt2_glc_ko 3.059318\n", - "RPE_glc_ko -0.292963\n", - "RPI_glc_ko -0.292963\n", - "SUCDi_glc_ko 7.011377\n", - "SUCOAS_glc_ko -7.011377\n", - "TALA_glc_ko -0.072915\n", - "THD2_glc_ko 3.367243\n", - "TKT1_glc_ko -0.072915\n", - "TKT2_glc_ko -0.220048\n", - "TPI_glc_ko -0.405412\n", - "EX_glu__L_e_glc_ko 2.222409\n", - "EX_h2o_e_glc_ko 18.390210\n", - "EX_h_e_glc_ko 2.780701\n", - "EX_nh4_e_glc_ko -4.444818\n", - "EX_o2_e_glc_ko -16.680853\n", - "EX_pi_e_glc_ko -1.499335\n", - "EX_pyr_e_glc_ko -3.059318\n", - "EX_acald_e_glc_ko -0.288725\n", - "EX_akg_e_glc_ko -3.390348\n", - "EX_co2_e_glc_ko 13.294545\n", - "EX_etoh_e_glc_ko -7.521941" + " glc_ko nh4_ko Total\n", + "Metabolite \n", + "glc__D_e 0.000000 -10.000000 -10.00000\n", + "gln__L_e 0.000000 0.000000 0.00000\n", + "glu__L_e 4.532343 -4.532343 0.00000\n", + "h2o_e 7.462523 23.220295 30.68282\n", + "h_e -6.134506 22.808289 16.67378\n", + "lac__D_e 0.000000 0.000000 0.00000\n", + "mal__L_e 0.000000 0.000000 0.00000\n", + "nh4_e -4.532343 0.000000 -4.53234\n", + "o2_e -5.196352 -18.470761 -23.66711\n", + "pi_e 0.000000 -3.057719 -3.05772\n", + "pyr_e 0.000000 0.000000 0.00000\n", + "ac_e -6.134506 6.134506 0.00000\n", + "acald_e 0.000000 0.000000 0.00000\n", + "succ_e 0.000000 0.000000 0.00000\n", + "akg_e -4.532343 4.532343 0.00000\n", + "co2_e 9.064686 15.563372 24.62806\n", + "etoh_e 1.602163 -1.602163 0.00000\n", + "for_e 0.000000 0.000000 0.00000\n", + "fru_e 0.000000 0.000000 0.00000\n", + "fum_e 0.000000 0.000000 0.00000" ] }, - "execution_count": 72, + "execution_count": 20, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "solution.find('glc_ko')" + "exchanges(community,solution)" ] }, { @@ -1465,7 +1600,7 @@ }, { "cell_type": "code", - "execution_count": 53, + "execution_count": 21, "id": "c4727cf5", "metadata": {}, "outputs": [], @@ -1475,7 +1610,7 @@ }, { "cell_type": "code", - "execution_count": 54, + "execution_count": 22, "id": "c80e5339", "metadata": {}, "outputs": [ @@ -1532,7 +1667,7 @@ "community_growth 8.311956e-01" ] }, - "execution_count": 54, + "execution_count": 22, "metadata": {}, "output_type": "execute_result" } @@ -1552,7 +1687,7 @@ }, { "cell_type": "code", - "execution_count": 55, + "execution_count": 23, "id": "e6698a36", "metadata": {}, "outputs": [ @@ -1587,35 +1722,112 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_glc_ko\n", - " 4.545680e-11\n", + " 0.227885\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_nh4_ko\n", - " 8.311956e-01\n", + " 0.594999\n", " \n", " \n", " community_growth\n", - " 8.311956e-01\n", + " 0.822884\n", " \n", " \n", "\n", "" ], "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_glc_ko 4.545680e-11\n", - "BIOMASS_Ecoli_core_w_GAM_nh4_ko 8.311956e-01\n", - "community_growth 8.311956e-01" + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.227885\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.594999\n", + "community_growth 0.822884" + ] + }, + "execution_count": 23, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "solution=sim.simulate(method=regComFBA,constraints=M9)\n", + "solution.find('BIOMASS|growth', sort=True, show_nulls=True)" + ] + }, + { + "cell_type": "markdown", + "id": "917a6ee9", + "metadata": {}, + "source": [ + "By default, regComFBA considers a confidence on community growth of 99%. However, you can relax this constraint to a lower value, e.g., `obj_frac=0.9` (90%)" + ] + }, + { + "cell_type": "code", + "execution_count": 24, + "id": "e734a88b", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_glc_ko0.374038
BIOMASS_Ecoli_core_w_GAM_nh4_ko0.374038
community_growth0.748076
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_glc_ko 0.374038\n", + "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.374038\n", + "community_growth 0.748076" ] }, - "execution_count": 55, + "execution_count": 24, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "solution=sim.simulate(method=regComFBA,constraints=M9,obj_frac=1)\n", + "solution=sim.simulate(method=regComFBA,constraints=M9,obj_frac=0.9)\n", "solution.find('BIOMASS|growth', sort=True, show_nulls=True)" ] }, @@ -1639,7 +1851,7 @@ }, { "cell_type": "code", - "execution_count": 56, + "execution_count": 25, "id": "2214667c", "metadata": {}, "outputs": [ @@ -1647,7 +1859,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.92it/s]\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.91it/s]\n" ] } ], @@ -1665,7 +1877,7 @@ }, { "cell_type": "code", - "execution_count": 57, + "execution_count": 26, "id": "50794ba1", "metadata": {}, "outputs": [ @@ -1677,7 +1889,7 @@ "nh4_ko\t0.9751156149211829" ] }, - "execution_count": 57, + "execution_count": 26, "metadata": {}, "output_type": "execute_result" } @@ -1696,7 +1908,7 @@ }, { "cell_type": "code", - "execution_count": 58, + "execution_count": 27, "id": "e5b8887e", "metadata": {}, "outputs": [ @@ -1808,7 +2020,7 @@ "4 nh4_ko glc_ko h_e 2.547897" ] }, - "execution_count": 58, + "execution_count": 27, "metadata": {}, "output_type": "execute_result" } @@ -1827,7 +2039,7 @@ }, { "cell_type": "code", - "execution_count": 59, + "execution_count": 28, "id": "26e96715", "metadata": { "scrolled": true @@ -1843,7 +2055,7 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "58c1323d2e4c444f9e90aea6adefeb26", + "model_id": "203d7c4cae644908abaaf1042493cc6f", "version_major": 2, "version_minor": 0 }, @@ -1866,7 +2078,7 @@ }, { "cell_type": "code", - "execution_count": 60, + "execution_count": 29, "id": "3fe40d10", "metadata": {}, "outputs": [ @@ -1880,7 +2092,7 @@ { "data": { "application/vnd.jupyter.widget-view+json": { - "model_id": "23e22a45efbc417fab78caf8968134f4", + "model_id": "52aa95a336714110afb10f1d5ee248ca", "version_major": 2, "version_minor": 0 }, @@ -1912,7 +2124,7 @@ }, { "cell_type": "code", - "execution_count": 61, + "execution_count": 30, "id": "71695f63", "metadata": {}, "outputs": [ @@ -1955,7 +2167,7 @@ }, { "cell_type": "code", - "execution_count": 62, + "execution_count": 31, "id": "34220805", "metadata": {}, "outputs": [], @@ -1973,19 +2185,19 @@ }, { "cell_type": "code", - "execution_count": 63, + "execution_count": 32, "id": "1c660055", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "objective: 0.828309078247319\n", + "objective: 0.8283090782473191\n", "Status: OPTIMAL\n", "Method:FBA" ] }, - "execution_count": 63, + "execution_count": 32, "metadata": {}, "output_type": "execute_result" } @@ -1999,7 +2211,7 @@ }, { "cell_type": "code", - "execution_count": 64, + "execution_count": 33, "id": "ecb0bce0", "metadata": {}, "outputs": [ @@ -2051,7 +2263,7 @@ "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.728309" ] }, - "execution_count": 64, + "execution_count": 33, "metadata": {}, "output_type": "execute_result" } @@ -2070,7 +2282,7 @@ }, { "cell_type": "code", - "execution_count": 65, + "execution_count": 34, "id": "7ecc37ca", "metadata": {}, "outputs": [], @@ -2083,7 +2295,7 @@ }, { "cell_type": "code", - "execution_count": 66, + "execution_count": 35, "id": "77f8eed9", "metadata": {}, "outputs": [ @@ -2091,7 +2303,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.30it/s]\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.61it/s]\n" ] } ], @@ -2102,7 +2314,7 @@ }, { "cell_type": "code", - "execution_count": 67, + "execution_count": 36, "id": "7d604601", "metadata": {}, "outputs": [ @@ -2163,7 +2375,7 @@ "BIOMASS_Ecoli_core_w_GAM_nh4_ko 0.407572" ] }, - "execution_count": 67, + "execution_count": 36, "metadata": {}, "output_type": "execute_result" } @@ -2176,7 +2388,7 @@ }, { "cell_type": "code", - "execution_count": 68, + "execution_count": 37, "id": "6402d86c", "metadata": {}, "outputs": [ @@ -2242,7 +2454,7 @@ "community_growth {'Biomass_glc_ko': -1, 'Biomass_nh4_ko': -1} {} " ] }, - "execution_count": 68, + "execution_count": 37, "metadata": {}, "output_type": "execute_result" } @@ -2261,7 +2473,7 @@ }, { "cell_type": "code", - "execution_count": 69, + "execution_count": 38, "id": "575721c6", "metadata": {}, "outputs": [ @@ -2318,7 +2530,7 @@ "community_growth 0.105388" ] }, - "execution_count": 69, + "execution_count": 38, "metadata": {}, "output_type": "execute_result" } @@ -2343,12 +2555,13 @@ "id": "3f23584e", "metadata": {}, "source": [ - "SCS (species coupling score): measures the dependency of one species in the presence of the others to survive" + "### Species Coupling Score\n", + "**SCS** (species coupling score): measures the dependency of one species in the presence of the others to survive" ] }, { "cell_type": "code", - "execution_count": 70, + "execution_count": 39, "id": "45d28b6e", "metadata": {}, "outputs": [ @@ -2356,7 +2569,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.69it/s]\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.89it/s]\n" ] }, { @@ -2407,7 +2620,7 @@ "nh4_ko {'glc_ko': 1.0}" ] }, - "execution_count": 70, + "execution_count": 39, "metadata": {}, "output_type": "execute_result" } @@ -2421,12 +2634,13 @@ "id": "2a521e6e", "metadata": {}, "source": [ - "MUS (metabolite uptake score): measures how frequently a species needs to uptake a metabolite to survive" + "### Metabolite Uptake Score\n", + "**MUS** (metabolite uptake score): measures how frequently a species needs to uptake a metabolite to survive" ] }, { "cell_type": "code", - "execution_count": 71, + "execution_count": 40, "id": "f779b482", "metadata": {}, "outputs": [ @@ -2478,7 +2692,7 @@ "nh4_ko {'ac_e': 0.07692307692307693, 'acald_e': 0.076..." ] }, - "execution_count": 71, + "execution_count": 40, "metadata": {}, "output_type": "execute_result" } @@ -2490,7 +2704,7 @@ }, { "cell_type": "code", - "execution_count": 38, + "execution_count": 41, "id": "d6175f02", "metadata": {}, "outputs": [ @@ -2519,7 +2733,7 @@ " 'succ_e': 0.03}" ] }, - "execution_count": 38, + "execution_count": 41, "metadata": {}, "output_type": "execute_result" } @@ -2530,7 +2744,7 @@ }, { "cell_type": "code", - "execution_count": 39, + "execution_count": 42, "id": "9449a68c", "metadata": {}, "outputs": [ @@ -2559,7 +2773,7 @@ " 'succ_e': 0.0}" ] }, - "execution_count": 39, + "execution_count": 42, "metadata": {}, "output_type": "execute_result" } @@ -2573,12 +2787,13 @@ "id": "19703e1f", "metadata": {}, "source": [ - "MPS (metabolite production score): measures the ability of a species to produce a metabolite" + "### Metabolite Production Score\n", + "**MPS** (metabolite production score): measures the ability of a species to produce a metabolite" ] }, { "cell_type": "code", - "execution_count": 40, + "execution_count": 43, "id": "095e8c80", "metadata": {}, "outputs": [ @@ -2630,7 +2845,7 @@ "nh4_ko {'etoh_e': 1, 'for_e': 1, 'h2o_e': 1, 'pyr_e':..." ] }, - "execution_count": 40, + "execution_count": 43, "metadata": {}, "output_type": "execute_result" } @@ -2645,12 +2860,13 @@ "id": "1fc8ec46", "metadata": {}, "source": [ - "MRO (metabolic resource overlap): calculates how much the species compete for the same metabolites." + "### Metabolic Resource Overlap\n", + "**MRO** (metabolic resource overlap): calculates how much the species compete for the same metabolites." ] }, { "cell_type": "code", - "execution_count": 41, + "execution_count": 44, "id": "761408d5", "metadata": {}, "outputs": [ @@ -2692,11 +2908,11 @@ " \n", " \n", " community_medium\n", - " {o2, pi, glu}\n", + " {pi, o2, glu}\n", " \n", " \n", " individual_media\n", - " {'glc_ko': {'pi', 'pyr', 'nh4', 'o2'}, 'nh4_ko...\n", + " {'glc_ko': {'pi', 'pyr', 'o2', 'nh4'}, 'nh4_ko...\n", " \n", " \n", "\n", @@ -2705,11 +2921,11 @@ "text/plain": [ " Value\n", "Attribute \n", - "community_medium {o2, pi, glu}\n", - "individual_media {'glc_ko': {'pi', 'pyr', 'nh4', 'o2'}, 'nh4_ko..." + "community_medium {pi, o2, glu}\n", + "individual_media {'glc_ko': {'pi', 'pyr', 'o2', 'nh4'}, 'nh4_ko..." ] }, - "execution_count": 41, + "execution_count": 44, "metadata": {}, "output_type": "execute_result" } @@ -2722,7 +2938,7 @@ }, { "cell_type": "code", - "execution_count": 42, + "execution_count": 45, "id": "2f72f3c5", "metadata": {}, "outputs": [ @@ -2732,7 +2948,7 @@ "{'nh4', 'o2', 'pi', 'pyr'}" ] }, - "execution_count": 42, + "execution_count": 45, "metadata": {}, "output_type": "execute_result" } @@ -2743,7 +2959,7 @@ }, { "cell_type": "code", - "execution_count": 43, + "execution_count": 46, "id": "d5461666", "metadata": {}, "outputs": [ @@ -2753,7 +2969,7 @@ "{'glc', 'glu', 'pi'}" ] }, - "execution_count": 43, + "execution_count": 46, "metadata": {}, "output_type": "execute_result" } diff --git a/examples/09-crossfeeding.ipynb b/examples/09-crossfeeding.ipynb index 748b8b48..42ecc44b 100644 --- a/examples/09-crossfeeding.ipynb +++ b/examples/09-crossfeeding.ipynb @@ -5,7 +5,7 @@ "id": "e5773faf", "metadata": {}, "source": [ - "# MEWpy Optimization\n", + "# MEWpy Community Optimization\n", "\n", "\n", "Author: Vitor Pereira\n", @@ -392,7 +392,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "100%|███████████████████████████████████████| 137/137 [00:00<00:00, 2197.73it/s]" + "100%|███████████████████████████████████████| 137/137 [00:00<00:00, 2228.69it/s]" ] }, { @@ -414,56 +414,56 @@ "output_type": "stream", "text": [ "Eval(s)| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev|\n", - " 100| 0.000000 0.873922 0.000000 0.139131 0.243433| 1.000000 50.000000 27.000000 24.910000 14.832461|\n", - " 200| 0.000000 0.873922 0.196462 0.252733 0.255846| 1.000000 50.000000 13.500000 20.180000 16.669361|\n", - " 300| 0.000000 0.873922 0.211663 0.353210 0.318573| 1.000000 50.000000 17.000000 21.520000 16.222503|\n", - " 400| 0.000000 0.873922 0.374230 0.390360 0.341932| 1.000000 50.000000 21.000000 24.030000 16.826441|\n", - " 500| 0.000000 0.873922 0.374230 0.397523 0.340082| 2.000000 50.000000 21.500000 24.690000 16.496481|\n", - " 600| 0.000000 0.873922 0.350513 0.331092 0.327334| 3.000000 50.000000 26.000000 28.780000 16.620217|\n", - " 700| 0.000000 0.873922 0.000000 0.265574 0.330570| 3.000000 50.000000 47.000000 33.640000 16.697617|\n", - " 800| 0.000000 0.873922 0.000000 0.221614 0.316088| 6.000000 50.000000 48.000000 36.320000 15.811312|\n", - " 900| 0.000000 0.873922 0.000000 0.193541 0.304936| 7.000000 50.000000 49.000000 38.570000 15.257297|\n", - " 1000| 0.000000 0.873922 0.000000 0.142570 0.278743| 8.000000 50.000000 50.000000 42.120000 14.027316|\n", - " 1100| 0.000000 0.873922 0.000000 0.057600 0.188195| 9.000000 50.000000 50.000000 46.910000 9.396909|\n", - " 1200| 0.000000 0.873922 0.000000 0.065348 0.191490| 9.000000 50.000000 50.000000 46.410000 9.684106|\n", - " 1300| 0.000000 0.873922 0.000000 0.082827 0.222156| 9.000000 50.000000 50.000000 45.640000 10.836531|\n", - " 1400| 0.000000 0.873922 0.000000 0.078129 0.218867| 9.000000 50.000000 50.000000 45.960000 10.482290|\n", - " 1500| 0.000000 0.873922 0.000000 0.080059 0.219020| 9.000000 50.000000 50.000000 45.860000 10.468066|\n", - " 1600| 0.000000 0.873922 0.000000 0.090751 0.227000| 9.000000 50.000000 50.000000 45.240000 10.943601|\n", - " 1700| 0.000000 0.873922 0.000000 0.095364 0.239419| 9.000000 50.000000 50.000000 45.250000 11.178886|\n", - " 1800| 0.000000 0.873922 0.000000 0.109855 0.252298| 9.000000 50.000000 50.000000 44.440000 11.772273|\n", - " 1900| 0.000000 0.873922 0.000000 0.102677 0.248593| 9.000000 50.000000 50.000000 44.900000 11.425848|\n", - " 2000| 0.000000 0.873922 0.000000 0.092484 0.246764| 9.000000 50.000000 50.000000 45.660000 10.985645|\n", - " 2100| 0.000000 0.873922 0.000000 0.092520 0.246780| 9.000000 50.000000 50.000000 45.670000 10.970921|\n", - " 2200| 0.000000 0.873922 0.000000 0.114860 0.275620| 9.000000 50.000000 50.000000 44.930000 12.014371|\n", - " 2300| 0.000000 0.873922 0.000000 0.118989 0.280689| 9.000000 50.000000 50.000000 44.900000 11.962859|\n", - " 2400| 0.000000 0.873922 0.000000 0.117064 0.280838| 9.000000 50.000000 50.000000 44.960000 11.973237|\n", - " 2500| 0.000000 0.873922 0.000000 0.129394 0.288685| 9.000000 50.000000 50.000000 44.320000 12.302748|\n", - " 2600| 0.000000 0.873922 0.000000 0.147377 0.302901| 9.000000 50.000000 50.000000 43.730000 12.674269|\n", - " 2700| 0.000000 0.873922 0.000000 0.150088 0.304025| 9.000000 50.000000 50.000000 43.620000 12.640237|\n", - " 2800| 0.000000 0.873922 0.000000 0.235088 0.342419| 9.000000 50.000000 50.000000 40.020000 13.902503|\n", - " 2900| 0.000000 0.873922 0.000000 0.202618 0.319993| 9.000000 50.000000 50.000000 41.310000 13.243636|\n", - " 3000| 0.000000 0.873922 0.196462 0.326035 0.345409| 9.000000 50.000000 39.000000 36.230000 14.084641|\n", - " 3100| 0.000000 0.873922 0.374230 0.492858 0.324564| 8.000000 50.000000 30.000000 30.160000 13.029751|\n", - " 3200| 0.182527 0.873922 0.211663 0.478488 0.314659| 8.000000 50.000000 34.000000 32.440000 13.642815|\n", - " 3300| 0.182527 0.873922 0.519491 0.522958 0.315752| 8.000000 50.000000 29.000000 30.820000 13.639927|\n", - " 3400| 0.182527 0.873922 0.211663 0.494350 0.321601| 8.000000 50.000000 35.000000 32.520000 13.948104|\n", - " 3500| 0.182527 0.873922 0.729735 0.558824 0.319162| 8.000000 50.000000 29.000000 29.590000 13.028503|\n", - " 3600| 0.182527 0.873922 0.796841 0.583404 0.311285| 8.000000 50.000000 28.500000 28.940000 12.594300|\n", - " 3700| 0.182527 0.873922 0.796841 0.570842 0.316299| 8.000000 50.000000 29.500000 29.780000 12.633748|\n", - " 3800| 0.182527 0.873922 0.814298 0.592014 0.317421| 8.000000 50.000000 29.500000 30.400000 12.545119|\n", - " 3900| 0.192520 0.873922 0.814298 0.586601 0.319686| 8.000000 50.000000 31.000000 30.700000 12.088424|\n", - " 4000| 0.192520 0.873922 0.814298 0.588297 0.318581| 8.000000 50.000000 31.000000 31.580000 12.439598|\n", - " 4100| 0.192520 0.873922 0.814298 0.576526 0.322905| 8.000000 50.000000 32.500000 32.600000 12.675962|\n", - " 4200| 0.000000 0.873922 0.858307 0.639750 0.312014| 8.000000 50.000000 30.000000 31.280000 12.782864|\n", - " 4300| 0.000000 0.873922 0.858307 0.613869 0.320631| 8.000000 50.000000 31.000000 32.580000 12.893549|\n", - " 4400| 0.192520 0.873922 0.814298 0.576304 0.324719| 8.000000 50.000000 33.000000 34.650000 12.492698|\n", - " 4500| 0.192520 0.873922 0.495524 0.529611 0.327419| 8.000000 50.000000 38.500000 36.610000 12.712903|\n", - " 4600| 0.192520 0.873922 0.814298 0.558426 0.327530| 8.000000 50.000000 35.000000 36.260000 12.128990|\n", - " 4700| 0.192520 0.873922 0.863813 0.632796 0.312936| 8.000000 50.000000 34.000000 34.640000 11.258348|\n", - " 4800| 0.192520 0.873922 0.833819 0.569717 0.325147| 9.000000 50.000000 35.500000 36.240000 11.402737|\n", - " 4900| 0.192520 0.873922 0.717202 0.540942 0.326207| 9.000000 50.000000 37.000000 38.110000 10.238061|\n", - " 5000| 0.192520 0.873922 0.211663 0.497099 0.320723| 27.000000 50.000000 43.000000 40.960000 7.266251|\n" + " 100| 0.000000 0.873922 0.000000 0.094155 0.212587| 2.000000 50.000000 25.500000 26.520000 13.508871|\n", + " 200| 0.000000 0.873922 0.000000 0.142907 0.223260| 2.000000 50.000000 37.000000 29.390000 15.469903|\n", + " 300| 0.000000 0.873922 0.188335 0.204816 0.256883| 3.000000 50.000000 25.000000 28.560000 16.134014|\n", + " 400| 0.000000 0.873922 0.191561 0.258462 0.303251| 3.000000 50.000000 25.000000 29.020000 15.948655|\n", + " 500| 0.000000 0.873922 0.000000 0.203612 0.321562| 4.000000 50.000000 47.000000 36.520000 16.263136|\n", + " 600| 0.000000 0.873922 0.000000 0.169343 0.305701| 4.000000 50.000000 49.000000 39.560000 15.225190|\n", + " 700| 0.000000 0.873922 0.000000 0.113731 0.262460| 4.000000 50.000000 50.000000 43.540000 12.904588|\n", + " 800| 0.000000 0.873922 0.000000 0.038807 0.154747| 17.000000 50.000000 50.000000 47.980000 6.702209|\n", + " 900| 0.000000 0.873922 0.000000 0.037481 0.154584| 17.000000 50.000000 50.000000 48.190000 6.487981|\n", + " 1000| 0.000000 0.873922 0.000000 0.047734 0.175101| 17.000000 50.000000 50.000000 47.810000 7.056479|\n", + " 1100| 0.000000 0.873922 0.000000 0.056311 0.192677| 17.000000 50.000000 50.000000 47.520000 7.539867|\n", + " 1200| 0.000000 0.873922 0.000000 0.033548 0.132662| 17.000000 50.000000 50.000000 48.140000 6.133547|\n", + " 1300| 0.000000 0.873922 0.000000 0.030930 0.131903| 17.000000 50.000000 50.000000 48.320000 6.052900|\n", + " 1400| 0.000000 0.873922 0.000000 0.030930 0.131903| 17.000000 50.000000 50.000000 48.320000 6.052900|\n", + " 1500| 0.000000 0.873922 0.000000 0.030930 0.131903| 17.000000 50.000000 50.000000 48.320000 6.052900|\n", + " 1600| 0.000000 0.873922 0.000000 0.030930 0.131903| 17.000000 50.000000 50.000000 48.320000 6.052900|\n", + " 1700| 0.000000 0.873922 0.000000 0.026877 0.129660| 17.000000 50.000000 50.000000 48.680000 5.589061|\n", + " 1800| 0.000000 0.873922 0.000000 0.037733 0.155549| 17.000000 50.000000 50.000000 48.170000 6.594020|\n", + " 1900| 0.000000 0.873922 0.000000 0.039759 0.156362| 17.000000 50.000000 50.000000 48.030000 6.741595|\n", + " 2000| 0.000000 0.873922 0.000000 0.039759 0.156362| 17.000000 50.000000 50.000000 48.030000 6.741595|\n", + " 2100| 0.000000 0.873922 0.000000 0.043902 0.157991| 17.000000 50.000000 50.000000 47.660000 7.120702|\n", + " 2200| 0.000000 0.873922 0.000000 0.026858 0.129684| 18.000000 50.000000 50.000000 48.860000 5.153678|\n", + " 2300| 0.000000 0.873922 0.000000 0.035435 0.153754| 18.000000 50.000000 50.000000 48.580000 5.803757|\n", + " 2400| 0.000000 0.873922 0.000000 0.044012 0.174114| 18.000000 50.000000 50.000000 48.300000 6.375735|\n", + " 2500| 0.000000 0.873922 0.000000 0.063690 0.195810| 18.000000 50.000000 50.000000 47.480000 7.416846|\n", + " 2600| 0.000000 0.873922 0.000000 0.071165 0.196874| 18.000000 50.000000 50.000000 47.160000 7.514945|\n", + " 2700| 0.000000 0.873922 0.000000 0.097305 0.213853| 18.000000 50.000000 50.000000 46.130000 8.385291|\n", + " 2800| 0.000000 0.873922 0.000000 0.134903 0.244207| 17.000000 50.000000 50.000000 44.810000 9.184438|\n", + " 2900| 0.000000 0.873922 0.161760 0.196004 0.273987| 17.000000 50.000000 47.500000 42.900000 9.605727|\n", + " 3000| 0.000000 0.873922 0.179712 0.252433 0.288924| 17.000000 50.000000 41.500000 40.700000 10.020479|\n", + " 3100| 0.155911 0.873922 0.196462 0.369923 0.282715| 17.000000 50.000000 37.000000 35.630000 9.886005|\n", + " 3200| 0.155911 0.873922 0.232589 0.447223 0.307214| 17.000000 50.000000 34.500000 34.220000 10.501029|\n", + " 3300| 0.155911 0.873922 0.232589 0.406663 0.292806| 17.000000 50.000000 35.000000 35.330000 9.393673|\n", + " 3400| 0.155911 0.873922 0.232589 0.400302 0.291263| 17.000000 50.000000 36.000000 35.610000 8.986540|\n", + " 3500| 0.155911 0.873922 0.232589 0.437932 0.293585| 17.000000 50.000000 35.000000 34.770000 8.246035|\n", + " 3600| 0.155911 0.873922 0.362411 0.500389 0.306955| 17.000000 50.000000 35.000000 34.610000 8.724557|\n", + " 3700| 0.155911 0.873922 0.779384 0.555742 0.305622| 17.000000 50.000000 34.000000 34.910000 9.065423|\n", + " 3800| 0.155911 0.873922 0.779384 0.544807 0.309377| 17.000000 50.000000 36.000000 35.440000 9.565898|\n", + " 3900| 0.167609 0.873922 0.779384 0.539132 0.305551| 17.000000 50.000000 37.000000 36.130000 9.122121|\n", + " 4000| 0.192520 0.873922 0.373617 0.514491 0.303867| 17.000000 50.000000 37.500000 37.100000 9.009439|\n", + " 4100| 0.192520 0.873922 0.297500 0.485449 0.301365| 17.000000 50.000000 40.000000 37.950000 8.860446|\n", + " 4200| 0.192520 0.873922 0.373617 0.526419 0.299472| 17.000000 50.000000 38.000000 37.000000 8.506468|\n", + " 4300| 0.192520 0.873922 0.373617 0.499748 0.296973| 17.000000 50.000000 40.000000 37.300000 8.670063|\n", + " 4400| 0.192520 0.873922 0.373617 0.523666 0.298172| 17.000000 50.000000 40.000000 37.780000 8.686288|\n", + " 4500| 0.192520 0.873922 0.373617 0.498422 0.287853| 17.000000 50.000000 41.000000 38.780000 8.150558|\n", + " 4600| 0.192520 0.873922 0.373617 0.460710 0.280274| 17.000000 50.000000 41.500000 39.480000 8.194486|\n", + " 4700| 0.192520 0.873922 0.303103 0.451980 0.284337| 18.000000 50.000000 43.000000 40.170000 8.078434|\n", + " 4800| 0.196462 0.873922 0.373617 0.490371 0.284215| 18.000000 50.000000 42.000000 39.400000 7.696753|\n", + " 4900| 0.196462 0.873922 0.373617 0.486034 0.289674| 18.000000 50.000000 42.500000 39.530000 7.993066|\n", + " 5000| 0.196462 0.873922 0.660552 0.549178 0.295261| 18.000000 50.000000 42.000000 39.160000 8.237378|\n" ] } ], @@ -517,38 +517,38 @@ " \n", " \n", " 0\n", - " {'b3739': 0, 'b2284': 0, 'b2463': 0, 'b3114': ...\n", - " 50\n", - " 0.211663\n", - " 50.0\n", + " {'b1241': 0, 'b1773': 0, 'b1812': 0, 'b1602': ...\n", + " 18\n", + " 0.873922\n", + " 18.0\n", " \n", " \n", " 1\n", - " {'b3739': 0, 'b2284': 0, 'b1524': 0, 'b4232': ...\n", - " 50\n", - " 0.211663\n", - " 50.0\n", + " {'b0356': 0, 'b1812': 0, 'b4154': 0, 'b3114': ...\n", + " 23\n", + " 0.873922\n", + " 23.0\n", " \n", " \n", " 2\n", - " {'b3739': 0, 'b0903': 0, 'b2463': 0, 'b1524': ...\n", - " 35\n", - " 0.873922\n", - " 35.0\n", + " {'b0356': 0, 'b1812': 0, 'b0729': 0, 'b3114': ...\n", + " 33\n", + " 0.814298\n", + " 33.0\n", " \n", " \n", " 3\n", - " {'b3739': 0, 'b0903': 0, 'b4152': 0, 'b2463': ...\n", - " 34\n", - " 0.873922\n", - " 34.0\n", + " {'b0356': 0, 'b0729': 0, 'b3114': 0, 'b4395': ...\n", + " 35\n", + " 0.814298\n", + " 35.0\n", " \n", " \n", " 4\n", - " {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b4152': ...\n", - " 47\n", + " {'b2133': 0, 'b3114': 0, 'b2283': 0, 'b4395': ...\n", + " 46\n", " 0.211663\n", - " 47.0\n", + " 46.0\n", " \n", " \n", " ...\n", @@ -558,60 +558,60 @@ " ...\n", " \n", " \n", - " 70\n", - " {'b3739': 0, 'b2284': 0, 'b3114': 0, 'b1524': ...\n", - " 50\n", - " 0.200142\n", - " 50.0\n", + " 63\n", + " {'b0356': 0, 'b0729': 0, 'b3114': 0, 'b4395': ...\n", + " 37\n", + " 0.814298\n", + " 37.0\n", " \n", " \n", - " 71\n", - " {'b3739': 0, 'b4152': 0, 'b2463': 0, 'b1524': ...\n", - " 27\n", - " 0.873922\n", - " 27.0\n", + " 64\n", + " {'b0356': 0, 'b0729': 0, 'b2133': 0, 'b3114': ...\n", + " 35\n", + " 0.814298\n", + " 35.0\n", " \n", " \n", - " 72\n", - " {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b2279': ...\n", - " 50\n", - " 0.192520\n", - " 50.0\n", + " 65\n", + " {'b0356': 0, 'b0729': 0, 'b2133': 0, 'b3114': ...\n", + " 39\n", + " 0.814298\n", + " 39.0\n", " \n", " \n", - " 73\n", - " {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b2279': ...\n", - " 50\n", - " 0.192520\n", - " 50.0\n", + " 66\n", + " {'b0356': 0, 'b2029': 0, 'b0729': 0, 'b3114': ...\n", + " 43\n", + " 0.232589\n", + " 43.0\n", " \n", " \n", - " 74\n", - " {'b3739': 0, 'b2284': 0, 'b2279': 0, 'b4232': ...\n", - " 42\n", - " 0.211663\n", - " 42.0\n", + " 67\n", + " {'b0356': 0, 'b0729': 0, 'b3114': 0, 'b4395': ...\n", + " 43\n", + " 0.232589\n", + " 43.0\n", " \n", " \n", "\n", - "

75 rows × 4 columns

\n", + "

68 rows × 4 columns

\n", "" ], "text/plain": [ " Modification Size TargetFlux Size\n", - "0 {'b3739': 0, 'b2284': 0, 'b2463': 0, 'b3114': ... 50 0.211663 50.0\n", - "1 {'b3739': 0, 'b2284': 0, 'b1524': 0, 'b4232': ... 50 0.211663 50.0\n", - "2 {'b3739': 0, 'b0903': 0, 'b2463': 0, 'b1524': ... 35 0.873922 35.0\n", - "3 {'b3739': 0, 'b0903': 0, 'b4152': 0, 'b2463': ... 34 0.873922 34.0\n", - "4 {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b4152': ... 47 0.211663 47.0\n", + "0 {'b1241': 0, 'b1773': 0, 'b1812': 0, 'b1602': ... 18 0.873922 18.0\n", + "1 {'b0356': 0, 'b1812': 0, 'b4154': 0, 'b3114': ... 23 0.873922 23.0\n", + "2 {'b0356': 0, 'b1812': 0, 'b0729': 0, 'b3114': ... 33 0.814298 33.0\n", + "3 {'b0356': 0, 'b0729': 0, 'b3114': 0, 'b4395': ... 35 0.814298 35.0\n", + "4 {'b2133': 0, 'b3114': 0, 'b2283': 0, 'b4395': ... 46 0.211663 46.0\n", ".. ... ... ... ...\n", - "70 {'b3739': 0, 'b2284': 0, 'b3114': 0, 'b1524': ... 50 0.200142 50.0\n", - "71 {'b3739': 0, 'b4152': 0, 'b2463': 0, 'b1524': ... 27 0.873922 27.0\n", - "72 {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b2279': ... 50 0.192520 50.0\n", - "73 {'b1380': 0, 'b3739': 0, 'b2284': 0, 'b2279': ... 50 0.192520 50.0\n", - "74 {'b3739': 0, 'b2284': 0, 'b2279': 0, 'b4232': ... 42 0.211663 42.0\n", + "63 {'b0356': 0, 'b0729': 0, 'b3114': 0, 'b4395': ... 37 0.814298 37.0\n", + "64 {'b0356': 0, 'b0729': 0, 'b2133': 0, 'b3114': ... 35 0.814298 35.0\n", + "65 {'b0356': 0, 'b0729': 0, 'b2133': 0, 'b3114': ... 39 0.814298 39.0\n", + "66 {'b0356': 0, 'b2029': 0, 'b0729': 0, 'b3114': ... 43 0.232589 43.0\n", + "67 {'b0356': 0, 'b0729': 0, 'b3114': 0, 'b4395': ... 43 0.232589 43.0\n", "\n", - "[75 rows x 4 columns]" + "[68 rows x 4 columns]" ] }, "execution_count": 11, @@ -640,7 +640,7 @@ { "data": { "text/plain": [ - "objective: 0.21166294973531075\n", + "objective: 0.87392150696843\n", "Status: OPTIMAL\n", "Method:FBA" ] @@ -692,7 +692,7 @@ }, { "cell_type": "code", - "execution_count": 36, + "execution_count": 14, "id": "a5ead7e5", "metadata": {}, "outputs": [ @@ -700,7 +700,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.66it/s]\n" + "Organism: 100%|███████████████████████████████████| 2/2 [00:00<00:00, 8.93it/s]\n" ] } ], @@ -729,7 +729,7 @@ }, { "cell_type": "code", - "execution_count": 27, + "execution_count": 15, "id": "4f1a046b", "metadata": {}, "outputs": [], @@ -747,7 +747,7 @@ }, { "cell_type": "code", - "execution_count": 28, + "execution_count": 16, "id": "bf6d8ef2", "metadata": {}, "outputs": [], @@ -767,7 +767,7 @@ }, { "cell_type": "code", - "execution_count": 29, + "execution_count": 17, "id": "d0febc71", "metadata": {}, "outputs": [ @@ -782,7 +782,7 @@ "name": "stderr", "output_type": "stream", "text": [ - "100%|███████████████████████████████████████| 274/274 [00:00<00:00, 1762.72it/s]" + "100%|███████████████████████████████████████| 274/274 [00:00<00:00, 2169.25it/s]" ] }, { @@ -804,16 +804,16 @@ "output_type": "stream", "text": [ "Eval(s)| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev|\n", - " 100| 0.411442 0.411442 0.411442 0.411442 0.000000| 0.411442 0.411442 0.411442 0.411442 0.000000| 27.000000 50.000000 41.000000 40.320000 7.630046|\n", - " 200| 0.000000 0.411442 0.411442 0.402029 0.058629| 0.000000 0.461758 0.411442 0.403716 0.057891| 27.000000 59.000000 44.000000 42.830000 6.959964|\n", - " 300| 0.000000 0.612274 0.411442 0.371122 0.125882| 0.000000 0.461758 0.411442 0.367826 0.126195| 27.000000 60.000000 46.000000 44.210000 7.426029|\n", - " 400| 0.000000 0.654500 0.411442 0.354860 0.158462| 0.000000 0.617272 0.411442 0.338266 0.152988| 27.000000 60.000000 47.000000 46.560000 7.885835|\n", - " 500| 0.000000 0.654500 0.411442 0.355879 0.170375| 0.000000 0.617272 0.411442 0.326564 0.159411| 32.000000 60.000000 48.000000 46.960000 8.522816|\n", - " 600| 0.000000 0.654500 0.411442 0.415296 0.116799| 0.005164 0.628294 0.411442 0.371218 0.117568| 32.000000 60.000000 48.000000 47.050000 7.567529|\n", - " 700| 0.184155 0.663398 0.411442 0.443853 0.128858| 0.108767 0.628294 0.411442 0.356126 0.139089| 32.000000 60.000000 49.000000 48.120000 6.061815|\n", - " 800| 0.116572 0.663398 0.497999 0.447072 0.148912| 0.108767 0.684855 0.306071 0.364165 0.151863| 34.000000 60.000000 49.000000 48.510000 5.189403|\n", - " 900| 0.116571 0.663398 0.516813 0.463270 0.166916| 0.108767 0.684856 0.306071 0.343208 0.170854| 34.000000 60.000000 48.000000 48.230000 5.840985|\n", - " 1000| 0.109701 0.663398 0.516813 0.450969 0.170855| 0.108767 0.691726 0.306071 0.353349 0.174729| 34.000000 60.000000 48.000000 48.400000 6.297619|\n" + " 100| 0.411442 0.411442 0.411442 0.411442 0.000000| 0.411442 0.411442 0.411442 0.411442 0.000000| 18.000000 50.000000 40.500000 39.050000 7.537075|\n", + " 200| 0.000000 0.530967 0.411442 0.398931 0.071493| 0.000000 0.411442 0.411442 0.396293 0.071441| 18.000000 55.000000 42.000000 40.750000 7.549007|\n", + " 300| 0.000000 0.530967 0.411442 0.382266 0.107030| 0.000000 0.514193 0.411442 0.379078 0.106690| 26.000000 56.000000 46.000000 43.000000 7.840918|\n", + " 400| 0.000000 0.590050 0.411442 0.327590 0.171032| 0.000000 0.514193 0.411442 0.320356 0.168233| 26.000000 60.000000 48.000000 45.740000 8.028225|\n", + " 500| 0.000000 0.590050 0.411442 0.348735 0.157257| 0.000000 0.702452 0.411442 0.342972 0.158041| 26.000000 60.000000 49.000000 45.820000 8.486908|\n", + " 600| 0.000000 0.603937 0.411442 0.354252 0.163567| 0.000000 0.702452 0.411442 0.354139 0.167454| 26.000000 60.000000 46.000000 45.370000 8.686374|\n", + " 700| 0.000000 0.616702 0.411442 0.357153 0.170418| 0.000000 0.702452 0.411442 0.361139 0.179166| 26.000000 60.000000 42.000000 43.550000 8.985961|\n", + " 800| 0.000000 0.616702 0.397183 0.366638 0.172911| 0.000000 0.703604 0.411442 0.387718 0.187606| 26.000000 60.000000 42.000000 41.920000 7.505571|\n", + " 900| 0.000000 0.616702 0.305166 0.354514 0.173742| 0.000000 0.710323 0.514193 0.433893 0.190287| 26.000000 60.000000 41.000000 40.760000 6.412675|\n", + " 1000| 0.000000 0.616702 0.305619 0.357796 0.181375| 0.000000 0.710323 0.462816 0.427599 0.198018| 26.000000 60.000000 40.500000 41.080000 6.661351|\n" ] } ], @@ -838,7 +838,7 @@ }, { "cell_type": "code", - "execution_count": 30, + "execution_count": 18, "id": "cf72f00d", "metadata": {}, "outputs": [ @@ -873,43 +873,43 @@ " \n", " \n", " 0\n", - " {'b0733_ec1': 0, 'b0755_ec2': 0, 'b3739_ec1': ...\n", - " 52\n", - " 0.663398\n", - " 0.131374\n", - " 52.0\n", + " {'b3870_ec1': 0, 'b4395_ec2': 0, 'b0485_ec1': ...\n", + " 26\n", + " 0.411442\n", + " 4.114418e-01\n", + " 26.0\n", " \n", " \n", " 1\n", - " {'b3236_ec2': 0, 'b2282_ec2': 0, 'b3212_ec2': ...\n", + " {'b4395_ec2': 0, 'b0734_ec2': 0, 'b0978_ec2': ...\n", " 60\n", - " 0.411442\n", - " 0.411442\n", + " 0.000000\n", + " 2.819105e-14\n", " 60.0\n", " \n", " \n", " 2\n", - " {'b3236_ec2': 0, 'b2282_ec2': 0, 'b3739_ec1': ...\n", - " 58\n", - " 0.612274\n", - " 0.108767\n", - " 58.0\n", + " {'b4395_ec2': 0, 'b0734_ec2': 0, 'b3114_ec2': ...\n", + " 43\n", + " 0.616702\n", + " 1.279228e-01\n", + " 43.0\n", " \n", " \n", " 3\n", - " {'b2282_ec2': 0, 'b0733_ec1': 0, 'b3212_ec2': ...\n", - " 49\n", - " 0.109701\n", - " 0.691726\n", - " 49.0\n", + " {'b2283_ec1': 0, 'b0978_ec2': 0, 'b1478_ec2': ...\n", + " 58\n", + " 0.000000\n", + " 9.508554e-13\n", + " 58.0\n", " \n", " \n", " 4\n", - " {'b0755_ec2': 0, 'b3739_ec1': 0, 'b2925_ec2': ...\n", - " 34\n", - " 0.411442\n", - " 0.411442\n", - " 34.0\n", + " {'b1611_ec1': 0, 'b0721_ec1': 0, 'b0485_ec1': ...\n", + " 40\n", + " 0.101986\n", + " 7.103230e-01\n", + " 40.0\n", " \n", " \n", " ...\n", @@ -920,81 +920,81 @@ " ...\n", " \n", " \n", - " 81\n", - " {'b3236_ec2': 0, 'b2282_ec2': 0, 'b0755_ec2': ...\n", - " 51\n", - " 0.617272\n", - " 0.184155\n", - " 51.0\n", + " 66\n", + " {'b3870_ec1': 0, 'b2283_ec1': 0, 'b0721_ec1': ...\n", + " 36\n", + " 0.305166\n", + " 5.141929e-01\n", + " 36.0\n", " \n", " \n", - " 82\n", - " {'b3236_ec2': 0, 'b2282_ec2': 0, 'b0733_ec1': ...\n", - " 58\n", - " 0.467650\n", - " 0.287113\n", - " 58.0\n", + " 67\n", + " {'b4395_ec2': 0, 'b2283_ec1': 0, 'b3732_ec1': ...\n", + " 34\n", + " 0.120432\n", + " 7.024517e-01\n", + " 34.0\n", " \n", " \n", - " 83\n", - " {'b0755_ec2': 0, 'b3739_ec1': 0, 'b2925_ec2': ...\n", + " 68\n", + " {'b4395_ec2': 0, 'b0734_ec2': 0, 'b1136_ec1': ...\n", " 42\n", - " 0.516813\n", - " 0.306071\n", + " 0.530967\n", + " 2.670924e-01\n", " 42.0\n", " \n", " \n", - " 84\n", - " {'b2282_ec2': 0, 'b3212_ec2': 0, 'b0755_ec2': ...\n", - " 44\n", - " 0.516813\n", - " 0.306070\n", - " 44.0\n", + " 69\n", + " {'b3870_ec1': 0, 'b2283_ec1': 0, 'b0721_ec1': ...\n", + " 42\n", + " 0.305166\n", + " 5.141926e-01\n", + " 42.0\n", " \n", " \n", - " 85\n", - " {'b2282_ec2': 0, 'b0755_ec2': 0, 'b4395_ec2': ...\n", - " 47\n", - " 0.604702\n", - " 0.196725\n", - " 47.0\n", + " 70\n", + " {'b3870_ec1': 0, 'b2283_ec1': 0, 'b0721_ec1': ...\n", + " 42\n", + " 0.305166\n", + " 5.141926e-01\n", + " 42.0\n", " \n", " \n", "\n", - "

86 rows × 5 columns

\n", + "

71 rows × 5 columns

\n", "" ], "text/plain": [ " Modification Size TargetFlux \\\n", - "0 {'b0733_ec1': 0, 'b0755_ec2': 0, 'b3739_ec1': ... 52 0.663398 \n", - "1 {'b3236_ec2': 0, 'b2282_ec2': 0, 'b3212_ec2': ... 60 0.411442 \n", - "2 {'b3236_ec2': 0, 'b2282_ec2': 0, 'b3739_ec1': ... 58 0.612274 \n", - "3 {'b2282_ec2': 0, 'b0733_ec1': 0, 'b3212_ec2': ... 49 0.109701 \n", - "4 {'b0755_ec2': 0, 'b3739_ec1': 0, 'b2925_ec2': ... 34 0.411442 \n", + "0 {'b3870_ec1': 0, 'b4395_ec2': 0, 'b0485_ec1': ... 26 0.411442 \n", + "1 {'b4395_ec2': 0, 'b0734_ec2': 0, 'b0978_ec2': ... 60 0.000000 \n", + "2 {'b4395_ec2': 0, 'b0734_ec2': 0, 'b3114_ec2': ... 43 0.616702 \n", + "3 {'b2283_ec1': 0, 'b0978_ec2': 0, 'b1478_ec2': ... 58 0.000000 \n", + "4 {'b1611_ec1': 0, 'b0721_ec1': 0, 'b0485_ec1': ... 40 0.101986 \n", ".. ... ... ... \n", - "81 {'b3236_ec2': 0, 'b2282_ec2': 0, 'b0755_ec2': ... 51 0.617272 \n", - "82 {'b3236_ec2': 0, 'b2282_ec2': 0, 'b0733_ec1': ... 58 0.467650 \n", - "83 {'b0755_ec2': 0, 'b3739_ec1': 0, 'b2925_ec2': ... 42 0.516813 \n", - "84 {'b2282_ec2': 0, 'b3212_ec2': 0, 'b0755_ec2': ... 44 0.516813 \n", - "85 {'b2282_ec2': 0, 'b0755_ec2': 0, 'b4395_ec2': ... 47 0.604702 \n", + "66 {'b3870_ec1': 0, 'b2283_ec1': 0, 'b0721_ec1': ... 36 0.305166 \n", + "67 {'b4395_ec2': 0, 'b2283_ec1': 0, 'b3732_ec1': ... 34 0.120432 \n", + "68 {'b4395_ec2': 0, 'b0734_ec2': 0, 'b1136_ec1': ... 42 0.530967 \n", + "69 {'b3870_ec1': 0, 'b2283_ec1': 0, 'b0721_ec1': ... 42 0.305166 \n", + "70 {'b3870_ec1': 0, 'b2283_ec1': 0, 'b0721_ec1': ... 42 0.305166 \n", "\n", - " TargetFlux Size \n", - "0 0.131374 52.0 \n", - "1 0.411442 60.0 \n", - "2 0.108767 58.0 \n", - "3 0.691726 49.0 \n", - "4 0.411442 34.0 \n", - ".. ... ... \n", - "81 0.184155 51.0 \n", - "82 0.287113 58.0 \n", - "83 0.306071 42.0 \n", - "84 0.306070 44.0 \n", - "85 0.196725 47.0 \n", + " TargetFlux Size \n", + "0 4.114418e-01 26.0 \n", + "1 2.819105e-14 60.0 \n", + "2 1.279228e-01 43.0 \n", + "3 9.508554e-13 58.0 \n", + "4 7.103230e-01 40.0 \n", + ".. ... ... \n", + "66 5.141929e-01 36.0 \n", + "67 7.024517e-01 34.0 \n", + "68 2.670924e-01 42.0 \n", + "69 5.141926e-01 42.0 \n", + "70 5.141926e-01 42.0 \n", "\n", - "[86 rows x 5 columns]" + "[71 rows x 5 columns]" ] }, - "execution_count": 30, + "execution_count": 18, "metadata": {}, "output_type": "execute_result" } @@ -1006,13 +1006,13 @@ }, { "cell_type": "code", - "execution_count": 31, + "execution_count": 19, "id": "144cc4ef", "metadata": {}, "outputs": [ { "data": { - "image/png": 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\n", 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\n", 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" ] @@ -1035,17 +1035,17 @@ }, { "cell_type": "code", - "execution_count": 32, + "execution_count": 20, "id": "6a0f2afe", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "[0.293004792691598, 0.46175823055628923, 44.0];{'b0978_ec1': 0, 'b2282_ec1': 0, 'b0755_ec2': 0, 'b2296_ec2': 0, 'b3403_ec2': 0, 'b0723_ec1': 0, 'b0726_ec1': 0, 'b0721_ec2': 0, 'b1612_ec2': 0, 'b1101_ec1': 0, 'b2297_ec2': 0, 'b4122_ec1': 0, 'b4014_ec1': 0, 'b1478_ec1': 0, 'b2463_ec2': 0, 'b3114_ec1': 0, 'b2284_ec1': 0, 'b2579_ec1': 0, 'b3870_ec1': 0, 'b0727_ec1': 0, 'b3870_ec2': 0, 'b2465_ec2': 0, 'b4151_ec1': 0, 'b3739_ec2': 0, 'b3951_ec2': 0, 'b0755_ec1': 0, 'b2283_ec1': 0, 'b0721_ec1': 0, 'b0723_ec2': 0, 'b1854_ec2': 0, 'b0810_ec1': 0, 'b1241_ec2': 0, 'b1817_ec2': 0, 'b0811_ec2': 0, 'b3962_ec2': 0, 'b1479_ec1': 0, 'b1478_ec2': 0, 'b0474_ec1': 0, 'b1819_ec2': 0, 'b1819_ec1': 0, 'b2464_ec2': 0, 'b3114_ec2': 0, 'b1818_ec2': 0, 'b1852_ec2': 0}" + "[0.2161638927545335, 0.5385991304931342, 40.0];{'b4395_ec2': 0, 'b0485_ec1': 0, 'b3114_ec2': 0, 'b0729_ec2': 0, 'b2463_ec2': 0, 'b3213_ec1': 0, 'b0115_ec2': 0, 'b4122_ec2': 0, 'b1849_ec1': 0, 'b1241_ec1': 0, 'b3951_ec2': 0, 'b2976_ec2': 0, 'b4090_ec2': 0, 'b1621_ec1': 0, 'b0733_ec2': 0, 'b2458_ec2': 0, 'b2029_ec2': 0, 'b3870_ec2': 0, 'b2458_ec1': 0, 'b2287_ec1': 0, 'b1380_ec1': 0, 'b2297_ec2': 0, 'b1603_ec1': 0, 'b2925_ec2': 0, 'b3916_ec2': 0, 'b3962_ec2': 0, 'b0723_ec2': 0, 'b1241_ec2': 0, 'b0720_ec1': 0, 'b1817_ec2': 0, 'b1611_ec2': 0, 'b4015_ec2': 0, 'b2296_ec2': 0, 'b1812_ec1': 0, 'b0723_ec1': 0, 'b2133_ec1': 0, 'b3213_ec2': 0, 'b1819_ec2': 0, 'b1602_ec2': 0, 'b3236_ec2': 0}" ] }, - "execution_count": 32, + "execution_count": 20, "metadata": {}, "output_type": "execute_result" } @@ -1057,7 +1057,7 @@ }, { "cell_type": "code", - "execution_count": 38, + "execution_count": 21, "id": "9c1fc9ed-ad8a-44ab-b48a-f314db521dee", "metadata": {}, "outputs": [ @@ -1092,11 +1092,11 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec1\n", - " 0.151643\n", + " 0.151669\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec2\n", - " 0.610744\n", + " 0.610718\n", " \n", " \n", " community_growth\n", @@ -1109,12 +1109,12 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_ec1 0.151643\n", - "BIOMASS_Ecoli_core_w_GAM_ec2 0.610744\n", + "BIOMASS_Ecoli_core_w_GAM_ec1 0.151669\n", + "BIOMASS_Ecoli_core_w_GAM_ec2 0.610718\n", "community_growth 0.762387" ] }, - "execution_count": 38, + "execution_count": 21, "metadata": {}, "output_type": "execute_result" } @@ -1128,12 +1128,98 @@ "id": "1983ab2b-4143-4362-9e89-55e2c5ddd60e", "metadata": {}, "source": [ - "The previous FBA solution is one of many that results from the genes deletion. We can select one particular solution by considering some assumption such as the difference between the organisms growth is minimized while keeping the same community growth: " + "The previous FBA solution is one of many that result from the genes deletion. We can select one particular solution by considering some additional assumption such as: \n", + "- the organisms will try minimize enzyme ussage (pFBA)\n", + "- the difference between the organisms growth is minimized (regComFBA)" + ] + }, + { + "cell_type": "markdown", + "id": "7271c352-0f1b-4a66-a82d-85647f5647d2", + "metadata": {}, + "source": [ + "**pFBA**" ] }, { "cell_type": "code", - "execution_count": 43, + "execution_count": 22, + "id": "3e4b2ac0-91a1-41b2-bd58-23996a111bad", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
\n", + "\n", + "\n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + "
Flux rate
Reaction ID
BIOMASS_Ecoli_core_w_GAM_ec10.151669
BIOMASS_Ecoli_core_w_GAM_ec20.610718
community_growth0.762387
\n", + "
" + ], + "text/plain": [ + " Flux rate\n", + "Reaction ID \n", + "BIOMASS_Ecoli_core_w_GAM_ec1 0.151669\n", + "BIOMASS_Ecoli_core_w_GAM_ec2 0.610718\n", + "community_growth 0.762387" + ] + }, + "execution_count": 22, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "problem.simulate(solution=solution.values,method='pFBA').find('BIOMASS|growth',show_nulls=True)" + ] + }, + { + "cell_type": "markdown", + "id": "1f647264-190f-4fe6-98a9-7308ed96e4d4", + "metadata": {}, + "source": [ + "**regComFBA**" + ] + }, + { + "cell_type": "code", + "execution_count": 23, "id": "d0efbd3c", "metadata": {}, "outputs": [ @@ -1168,11 +1254,11 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec1\n", - " 0.293005\n", + " 0.216164\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec2\n", - " 0.461758\n", + " 0.538599\n", " \n", " \n", " community_growth\n", @@ -1185,12 +1271,12 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_ec1 0.293005\n", - "BIOMASS_Ecoli_core_w_GAM_ec2 0.461758\n", + "BIOMASS_Ecoli_core_w_GAM_ec1 0.216164\n", + "BIOMASS_Ecoli_core_w_GAM_ec2 0.538599\n", "community_growth 0.754763" ] }, - "execution_count": 43, + "execution_count": 23, "metadata": {}, "output_type": "execute_result" } @@ -1209,7 +1295,7 @@ }, { "cell_type": "code", - "execution_count": 44, + "execution_count": 24, "id": "19e526f3-e152-4164-a740-b53fa520172e", "metadata": {}, "outputs": [ @@ -1244,11 +1330,11 @@ " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec1\n", - " 0.343074\n", + " 0.281992\n", " \n", " \n", " BIOMASS_Ecoli_core_w_GAM_ec2\n", - " 0.343074\n", + " 0.404156\n", " \n", " \n", " community_growth\n", @@ -1261,12 +1347,12 @@ "text/plain": [ " Flux rate\n", "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_ec1 0.343074\n", - "BIOMASS_Ecoli_core_w_GAM_ec2 0.343074\n", + "BIOMASS_Ecoli_core_w_GAM_ec1 0.281992\n", + "BIOMASS_Ecoli_core_w_GAM_ec2 0.404156\n", "community_growth 0.686148" ] }, - "execution_count": 44, + "execution_count": 24, "metadata": {}, "output_type": "execute_result" } @@ -1277,15 +1363,15 @@ }, { "cell_type": "markdown", - "id": "e8055fce-3084-4fd8-b7d9-75ba2e4fb7df", + "id": "614281b9-b4a4-45a4-ae88-248559bd1e3c", "metadata": {}, "source": [ - "Other FBA methods can be used such as parsimonious FBA:" + "To have a first glimps to the interactions between the organism, we may look at the exchanges with the medium:" ] }, { "cell_type": "code", - "execution_count": 45, + "execution_count": 25, "id": "71d388c4-d81d-47ce-b191-57ad12541ced", "metadata": {}, "outputs": [ @@ -1310,81 +1396,216 @@ " \n", " \n", " \n", - " Flux rate\n", + " ec1\n", + " ec2\n", + " Total\n", " \n", " \n", - " Reaction ID\n", + " Metabolite\n", + " \n", + " \n", " \n", " \n", " \n", " \n", " \n", - " BIOMASS_Ecoli_core_w_GAM_ec1\n", - " 0.000000\n", + " glc__D_e\n", + " -1.000000e+01\n", + " -4.035703e-10\n", + " -10.00000\n", " \n", " \n", - " BIOMASS_Ecoli_core_w_GAM_ec2\n", - " 0.762387\n", + " gln__L_e\n", + " -0.000000e+00\n", + " -0.000000e+00\n", + " 0.00000\n", " \n", " \n", - " community_growth\n", - " 0.762387\n", + " glu__L_e\n", + " 9.001655e+00\n", + " -9.001655e+00\n", + " -0.00000\n", + " \n", + " \n", + " h2o_e\n", + " -1.451961e+01\n", + " 4.748387e+01\n", + " 32.96426\n", + " \n", + " \n", + " h_e\n", + " 9.896481e+00\n", + " 5.451275e+00\n", + " 15.34776\n", + " \n", + " \n", + " lac__D_e\n", + " -0.000000e+00\n", + " 1.491075e-10\n", + " 0.00000\n", + " \n", + " \n", + " mal__L_e\n", + " -0.000000e+00\n", + " -0.000000e+00\n", + " 0.00000\n", + " \n", + " \n", + " nh4_e\n", + " -1.018035e+01\n", + " 6.064782e+00\n", + " -4.11557\n", + " \n", + " \n", + " o2_e\n", + " -0.000000e+00\n", + " -2.659368e+01\n", + " -26.59368\n", + " \n", + " \n", + " pi_e\n", + " -7.952022e-01\n", + " -1.981345e+00\n", + " -2.77655\n", + " \n", + " \n", + " pyr_e\n", + " 5.819462e+00\n", + " -5.819462e+00\n", + " -0.00000\n", + " \n", + " \n", + " ac_e\n", + " 2.072098e-01\n", + " -0.000000e+00\n", + " 0.20721\n", + " \n", + " \n", + " acald_e\n", + " -4.704296e+01\n", + " 4.704296e+01\n", + " 0.00000\n", + " \n", + " \n", + " succ_e\n", + " 5.148543e-10\n", + " 3.085917e-13\n", + " 0.00000\n", + " \n", + " \n", + " akg_e\n", + " -9.234875e+00\n", + " 9.234875e+00\n", + " -0.00000\n", + " \n", + " \n", + " co2_e\n", + " 2.842858e+01\n", + " -9.623151e-01\n", + " 27.46626\n", + " \n", + " \n", + " etoh_e\n", + " 4.987583e+01\n", + " -4.987583e+01\n", + " -0.00000\n", + " \n", + " \n", + " for_e\n", + " 5.580235e-10\n", + " 1.355247e-09\n", + " 0.00000\n", + " \n", + " \n", + " fru_e\n", + " -0.000000e+00\n", + " -0.000000e+00\n", + " 0.00000\n", + " \n", + " \n", + " fum_e\n", + " -0.000000e+00\n", + " -0.000000e+00\n", + " 0.00000\n", " \n", " \n", "\n", "" ], "text/plain": [ - " Flux rate\n", - "Reaction ID \n", - "BIOMASS_Ecoli_core_w_GAM_ec1 0.000000\n", - "BIOMASS_Ecoli_core_w_GAM_ec2 0.762387\n", - "community_growth 0.762387" + " ec1 ec2 Total\n", + "Metabolite \n", + "glc__D_e -1.000000e+01 -4.035703e-10 -10.00000\n", + "gln__L_e -0.000000e+00 -0.000000e+00 0.00000\n", + "glu__L_e 9.001655e+00 -9.001655e+00 -0.00000\n", + "h2o_e -1.451961e+01 4.748387e+01 32.96426\n", + "h_e 9.896481e+00 5.451275e+00 15.34776\n", + "lac__D_e -0.000000e+00 1.491075e-10 0.00000\n", + "mal__L_e -0.000000e+00 -0.000000e+00 0.00000\n", + "nh4_e -1.018035e+01 6.064782e+00 -4.11557\n", + "o2_e -0.000000e+00 -2.659368e+01 -26.59368\n", + "pi_e -7.952022e-01 -1.981345e+00 -2.77655\n", + "pyr_e 5.819462e+00 -5.819462e+00 -0.00000\n", + "ac_e 2.072098e-01 -0.000000e+00 0.20721\n", + "acald_e -4.704296e+01 4.704296e+01 0.00000\n", + "succ_e 5.148543e-10 3.085917e-13 0.00000\n", + "akg_e -9.234875e+00 9.234875e+00 -0.00000\n", + "co2_e 2.842858e+01 -9.623151e-01 27.46626\n", + "etoh_e 4.987583e+01 -4.987583e+01 -0.00000\n", + "for_e 5.580235e-10 1.355247e-09 0.00000\n", + "fru_e -0.000000e+00 -0.000000e+00 0.00000\n", + "fum_e -0.000000e+00 -0.000000e+00 0.00000" ] }, - "execution_count": 45, + "execution_count": 25, "metadata": {}, "output_type": "execute_result" } ], "source": [ - "problem.simulate(solution=solution.values,method='pFBA').find('BIOMASS|growth',show_nulls=True)" + "from mewpy.com.analysis import exchanges\n", + "res = problem.simulate(solution=solution.values,method=regComFBA)\n", + "exchanges(community,res)" ] }, { "cell_type": "markdown", - "id": "2787a893", + "id": "bc0123c8-cc62-48d1-87a0-313ebfd96bed", "metadata": {}, "source": [ - "Me may also have a look to the reactions that were 'deleted'" + "Finally, we can audit the deleted reactions: " ] }, { "cell_type": "code", - "execution_count": 34, + "execution_count": 26, "id": "c92e07da", "metadata": {}, "outputs": [ { "data": { "text/plain": [ - "{'SUCDi_ec2': 0,\n", - " 'FRUpts2_ec2': 0,\n", - " 'PPCK_ec2': 0,\n", - " 'AKGDH_ec1': 0,\n", - " 'SUCDi_ec1': 0,\n", - " 'ME1_ec1': 0,\n", - " 'ADK1_ec1': 0,\n", - " 'G6PDH2r_ec2': 0,\n", - " 'GLNabc_ec2': 0,\n", - " 'FRUpts2_ec1': 0,\n", + "{'CS_ec1': 0,\n", + " 'PDH_ec2': 0,\n", " 'NADH16_ec1': 0,\n", - " 'FRD7_ec1': 0,\n", + " 'SUCOAS_ec2': 0,\n", + " 'LDH_D_ec1': 0,\n", + " 'GLUSy_ec1': 0,\n", + " 'SUCDi_ec1': 0,\n", + " 'GND_ec2': 0,\n", + " 'PTAr_ec2': 0,\n", " 'ME2_ec2': 0,\n", - " 'GLNabc_ec1': 0}" + " 'THD2_ec2': 0,\n", + " 'ICL_ec2': 0,\n", + " 'THD2_ec1': 0,\n", + " 'SUCDi_ec2': 0,\n", + " 'FRUpts2_ec2': 0,\n", + " 'NADTRHD_ec2': 0,\n", + " 'MDH_ec2': 0,\n", + " 'GLUSy_ec2': 0}" ] }, - "execution_count": 34, + "execution_count": 26, "metadata": {}, "output_type": "execute_result" } @@ -1393,10 +1614,21 @@ "problem.solution_to_constraints(solution.values)" ] }, + { + "cell_type": "markdown", + "id": "56af34d1", + "metadata": {}, + "source": [ + "## Next Steps:\n", + "You may now apply the modifications to the models and analyse further the solution using SMETANA and SteadyCom (see [notebook 8](08-community.ipynb)).\n", + "\n", + "You may also consider running other alternative optimization tasks considering different strategies (e.g. Gene Over/Under Expression) and alternative optimization objectives." + ] + }, { "cell_type": "code", "execution_count": null, - "id": "d8bd1cc7", + "id": "4c985d8d", "metadata": {}, "outputs": [], "source": [] From 07b14e44f30108b0e7fcfdc7aa4f2518625b70d1 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 29 Jun 2024 13:32:59 +0100 Subject: [PATCH 09/24] Add exchanges analysis for communities --- src/mewpy/com/analysis.py | 54 ++++++++++++++++++++++++++++++-- src/mewpy/com/com.py | 4 ++- src/mewpy/simulation/cobra.py | 2 +- src/mewpy/simulation/reframed.py | 2 +- 4 files changed, 57 insertions(+), 5 deletions(-) diff --git a/src/mewpy/com/analysis.py b/src/mewpy/com/analysis.py index 545ff97f..ec1a2fd4 100644 --- a/src/mewpy/com/analysis.py +++ b/src/mewpy/com/analysis.py @@ -22,15 +22,20 @@ from mewpy.solvers import solver_instance from mewpy.solvers.solver import VarType from mewpy.solvers.solution import Status -from mewpy.simulation import Environment +from mewpy.simulation import Environment, SimulationResult, get_simulator from mewpy.cobra.medium import minimal_medium from mewpy.util.constants import ModelConstants +from mewpy.com import CommunityModel from mewpy.util import AttrDict from warnings import warn from collections import Counter from itertools import combinations, chain from math import isinf, inf +import pandas as pd + +from typing import Union,List + def sc_score(community, environment=None, min_growth=0.1, n_solutions=100, verbose=True, abstol=1e-6, @@ -477,4 +482,49 @@ def ex_by_comp(compound): env = Environment.from_reactions(ex_rxns, max_uptake=max_uptake) if r_h2o is not None: env[r_h2o] = (-inf, inf) - return env \ No newline at end of file + return env + +def exchanges(com:CommunityModel, + solution:SimulationResult, + metabolites:Union[str,List[str]]=None): + """_summary_ + + Args: + com (CommunityModel): _description_ + solution (SimulationResult): _description_ + metabolites (Union[str,List[str]], optional): _description_. Defaults to None. + + Raises: + ValueError: _description_ + + Returns: + _type_: _description_ + """ + sim = get_simulator(solution.model) + exchange = sim.get_exchange_reactions() + m_r = sim.metabolite_reaction_lookup() + + if metabolites is None: + ext_mets = com.ext_mets + elif isinstance(metabolites,str): + ext_mets =[metabolites] + elif isinstance(metabolites,list): + ext_mets =metabolites + else: + raise ValueError('Metabolites should be a string, a list of strings or None') + res = dict() + orgs = com.organisms + for met in ext_mets: + res[met]={k:0.0 for k in orgs} + rxns = m_r[met] + for rx, st in rxns.items(): + if rx in exchange: + continue + org = com.reverse_map[rx][0] + v = solution.fluxes[rx] + res[met][org]=v + df = pd.DataFrame(res).transpose() + df.index.name = 'Metabolite' + df['Total'] = df.sum(axis=1).round(5) + return df + \ No newline at end of file diff --git a/src/mewpy/com/com.py b/src/mewpy/com/com.py index a28a044d..7943d1a5 100644 --- a/src/mewpy/com/com.py +++ b/src/mewpy/com/com.py @@ -62,9 +62,11 @@ def __init__( :param merge_biomasses: If a biomass equation is to be build requiring each organism to grow in acordance to a relative abundance. Default True. - If no abundance list is provided all organism will have equal abundance. + If no abundance list is provided, all organism will have equal abundance. :param add_compartments: If each organism external compartment is to be added to the community model. Default True. + :param balance_exchange: If the organisms uptakes should reflect their abundances. + This will normalize each organism flux value in acordance to the abundance. Default True. :param bool copy_models: if the models are to be copied, default True. :param str flavor: use 'cobrapy' or 'reframed. Default 'reframed'. """ diff --git a/src/mewpy/simulation/cobra.py b/src/mewpy/simulation/cobra.py index 6434af9c..e630654c 100644 --- a/src/mewpy/simulation/cobra.py +++ b/src/mewpy/simulation/cobra.py @@ -656,7 +656,7 @@ def simulate(self, else: status = self.__status_mapping[solution.status] - result = SimulationResult(model, + result = SimulationResult(self, solution.objective_value, fluxes=solution.fluxes.to_dict(OrderedDict), status=status, envcond=self.environmental_conditions, diff --git a/src/mewpy/simulation/reframed.py b/src/mewpy/simulation/reframed.py index 95785b33..2edbae71 100644 --- a/src/mewpy/simulation/reframed.py +++ b/src/mewpy/simulation/reframed.py @@ -627,7 +627,7 @@ def simulate(self, objective=None, method=SimulationMethod.FBA, else: status = self.__status_mapping[solution.status] - result = SimulationResult(self.model, solution.fobj, fluxes=solution.values, status=status, + result = SimulationResult(self, solution.fobj, fluxes=solution.values, status=status, envcond=self.environmental_conditions, model_constraints=self._constraints.copy(), simul_constraints=constraints, maximize=maximize, method=method) return result From 49b6be4822a94e661912e14d940a0b76c59841b0 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 29 Jun 2024 13:33:59 +0100 Subject: [PATCH 10/24] Bump to version 0.1.36 --- PKG-INFO | 9 ++++++--- README.md | 8 ++++++-- setup.cfg | 2 +- setup.py | 2 +- src/mewpy/__init__.py | 4 ++-- 5 files changed, 16 insertions(+), 9 deletions(-) diff --git a/PKG-INFO b/PKG-INFO index dfac1217..30130e3d 100644 --- a/PKG-INFO +++ b/PKG-INFO @@ -1,12 +1,13 @@ Metadata-Version: 2.1 Name: mewpy -Version: 0.1.35 +Version: 0.1.36 Summary: MEWpy - Metabolic Engineering in Python Home-page: https://github.com/BioSystemsUM/mewpy/ +Home-page: https://github.com/vmspereira/mewpy/ Author: Vitor Pereira / BiSBII CEB University of Minho Author-email: vpereira@ceb.uminho.pt License: GPL v3 License -Project-URL: Bug Tracker, https://github.com/BioSystemsUM/mewpy/issues +Project-URL: Bug Tracker, https://github.com/vmspereira/mewpy/issues Project-URL: Documentation, https://mewpy.readthedocs.io Keywords: strain optimization Classifier: Programming Language :: Python :: 3 @@ -35,6 +36,7 @@ It offers methods to explore different classes of constraint-based models (CBM) - Optimization: performs Evolutionary Computation based strain design optimization by knocking out (KO) or over/under expressing (OU) reactions, genes, or enzymes. - Omics data integration (eFlux, GIMME, iMAT); - Regulatory networks integration (rFBA, srFBA) +- Microbial Communities Modeling MEWPy currently supports REFRAMED and COBRApy simulation environments. @@ -54,5 +56,6 @@ Credits and License ------------------- Developed at: -- Centre of Biological Engineering, University of Minho (2019-) +- Centre of Biological Engineering, University of Minho (2019-2023) +- Mantained by Vítor Pereira (2019-) diff --git a/README.md b/README.md index 74ae6e44..9e31ba8d 100644 --- a/README.md +++ b/README.md @@ -7,9 +7,11 @@ MEWpy is an integrated Metabolic Engineering Workbench for strain design optimization. It offers methods to explore different classes of constraint-based models (CBM) for: -- Simulation: allows to simulate steady-state metabolic models, considering different formulations (e.g., GECKO, ETFL) and kinetic models; +- Simulating single organisms: allows to simulate steady-state metabolic models, considering different formulations (e.g., GECKO, ETFL) and kinetic models; +- Evolutionary Computation based strain design optimization by knocking out (KO) or over/under expressing (OU) reactions, genes or enzymes. - Omics data integration (eFlux, GIMME, iMAT); -- Optimization: performs Evolutionary Computation based strain design optimization by knocking out (KO) or over/under expressing (OU) reactions, genes or enzymes. +- Regulatory Networks integration; +- Microbial Community Modeling: Community simulation and optimization, SMETANA, SteadyCOM; MEWPy currently supports [REFRAMED](https://github.com/cdanielmachado/reframed) and [COBRApy](https://opencobra.github.io/cobrapy/) simulation environments. The optimization engine relies on either [inspyred](https://github.com/aarongarrett/inspyred) or [jMetalPy](https://github.com/jMetal/jMetalPy) packages. @@ -43,6 +45,8 @@ MEWPy requires a compatible linear programming solver, with installed Python dep ## Cite +If you use MEWpy in your research, please cite: + Vítor Pereira, Fernando Cruz, Miguel Rocha, MEWpy: a computational strain optimization workbench in Python, Bioinformatics, 2021; [https://doi.org/10.1093/bioinformatics/btab013](https://doi.org/10.1093/bioinformatics/btab013) ### Credits and License diff --git a/setup.cfg b/setup.cfg index 98f9d0b3..c0d8a0e7 100644 --- a/setup.cfg +++ b/setup.cfg @@ -1,5 +1,5 @@ [bumpversion] -current_version = 0.1.35 +current_version = 0.1.36 commit = True tag = False diff --git a/setup.py b/setup.py index e352820b..995848ae 100644 --- a/setup.py +++ b/setup.py @@ -12,7 +12,7 @@ setup( name='mewpy', - version='0.1.35', + version='0.1.36', python_requires='>=3.6', package_dir={'': 'src'}, packages=find_packages('src'), diff --git a/src/mewpy/__init__.py b/src/mewpy/__init__.py index 55b758e4..8fa614e0 100644 --- a/src/mewpy/__init__.py +++ b/src/mewpy/__init__.py @@ -13,9 +13,9 @@ from .simulation import get_simulator -__author__ = 'Vitor Pereira and CEB University of Minho (2019-2023)' +__author__ = 'Vitor Pereira (2019-) and CEB University of Minho (2019-2023)' __email__ = 'vpereira@ceb.uminho.pt' -__version__ = '0.1.35' +__version__ = '0.1.36' From 338866416e08d34d08ed1c72a5a222e22ffe9dfb Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 29 Jun 2024 21:33:54 +0100 Subject: [PATCH 11/24] update docs --- .gitignore | 146 +++++++++++++++++++++++++ docs/mewpy.cobra.rst | 37 +++++++ docs/mewpy.com.rst | 53 +++++++++ docs/mewpy.germ.algebra.rst | 53 +++++++++ docs/mewpy.germ.analysis.rst | 93 ++++++++++++++++ docs/mewpy.germ.lp.rst | 37 +++++++ docs/mewpy.germ.models.rst | 45 ++++++++ docs/mewpy.germ.rst | 23 ++++ docs/mewpy.germ.solution.rst | 37 +++++++ docs/mewpy.germ.variables.rst | 77 +++++++++++++ docs/mewpy.io.engines.rst | 93 ++++++++++++++++ docs/mewpy.io.rst | 48 ++++++-- docs/mewpy.model.rst | 8 ++ docs/mewpy.omics.integration.rst | 37 +++++++ docs/mewpy.omics.rst | 29 +++++ docs/mewpy.optimization.evaluation.rst | 45 ++++++++ docs/mewpy.optimization.inspyred.rst | 16 +++ docs/mewpy.optimization.jmetal.rst | 8 ++ docs/mewpy.optimization.rst | 7 +- docs/mewpy.problems.rst | 56 ++++++++++ docs/mewpy.regulation.rst | 85 -------------- docs/mewpy.rst | 8 +- docs/mewpy.simulation.rst | 48 ++++++++ docs/mewpy.solvers.rst | 93 ++++++++++++++++ docs/mewpy.util.rst | 77 +++++++++++++ docs/mewpy.utils.rst | 61 ----------- 26 files changed, 1157 insertions(+), 163 deletions(-) create mode 100644 docs/mewpy.cobra.rst create mode 100644 docs/mewpy.com.rst create mode 100644 docs/mewpy.germ.algebra.rst create mode 100644 docs/mewpy.germ.analysis.rst create mode 100644 docs/mewpy.germ.lp.rst create mode 100644 docs/mewpy.germ.models.rst create mode 100644 docs/mewpy.germ.rst create mode 100644 docs/mewpy.germ.solution.rst create mode 100644 docs/mewpy.germ.variables.rst create mode 100644 docs/mewpy.io.engines.rst create mode 100644 docs/mewpy.omics.integration.rst create mode 100644 docs/mewpy.omics.rst create mode 100644 docs/mewpy.optimization.evaluation.rst delete mode 100644 docs/mewpy.regulation.rst create mode 100644 docs/mewpy.solvers.rst create mode 100644 docs/mewpy.util.rst delete mode 100644 docs/mewpy.utils.rst diff --git a/.gitignore b/.gitignore index e6a9ec6e..cf9fd44a 100644 --- a/.gitignore +++ b/.gitignore @@ -17,3 +17,149 @@ run_tox.sh tests/reports/ .ipynb_checkpoints .DS_Store +builddoc/.buildinfo +builddoc/.nojekyll +builddoc/evaluation.html +builddoc/genindex.html +builddoc/germ.html +builddoc/index.html +builddoc/install.html +builddoc/main.html +builddoc/mewpy.html +builddoc/mewpy.io.html +builddoc/mewpy.model.data.html +builddoc/mewpy.model.html +builddoc/mewpy.optimization.html +builddoc/mewpy.optimization.inspyred.html +builddoc/mewpy.optimization.jmetal.html +builddoc/mewpy.problems.html +builddoc/mewpy.regulation.html +builddoc/mewpy.simulation.html +builddoc/mewpy.utils.html +builddoc/mewpy.visualization.html +builddoc/modules.html +builddoc/objects.inv +builddoc/optimization.html +builddoc/options.html +builddoc/problems.html +builddoc/py-modindex.html +builddoc/search.html +builddoc/searchindex.js +builddoc/simulation.html +builddoc/.doctrees/environment.pickle +builddoc/.doctrees/evaluation.doctree +builddoc/.doctrees/germ.doctree +builddoc/.doctrees/index.doctree +builddoc/.doctrees/install.doctree +builddoc/.doctrees/main.doctree +builddoc/.doctrees/mewpy.doctree +builddoc/.doctrees/mewpy.io.doctree +builddoc/.doctrees/mewpy.model.data.doctree +builddoc/.doctrees/mewpy.model.doctree +builddoc/.doctrees/mewpy.optimization.doctree +builddoc/.doctrees/mewpy.optimization.inspyred.doctree +builddoc/.doctrees/mewpy.optimization.jmetal.doctree +builddoc/.doctrees/mewpy.problems.doctree +builddoc/.doctrees/mewpy.regulation.doctree +builddoc/.doctrees/mewpy.simulation.doctree +builddoc/.doctrees/mewpy.utils.doctree +builddoc/.doctrees/mewpy.visualization.doctree +builddoc/.doctrees/modules.doctree +builddoc/.doctrees/optimization.doctree +builddoc/.doctrees/options.doctree +builddoc/.doctrees/problems.doctree +builddoc/.doctrees/simulation.doctree +builddoc/_images/envelope.png +builddoc/_images/germ_overview.png +builddoc/_images/mewpy-2.png +builddoc/_images/mewpy-3.png +builddoc/_images/mewpy-arch.png +builddoc/_modules/index.html +builddoc/_modules/mewpy.html +builddoc/_modules/mewpy/io.html +builddoc/_modules/mewpy/optimization.html +builddoc/_modules/mewpy/simulation.html +builddoc/_modules/mewpy/io/sbml.html +builddoc/_modules/mewpy/model/gecko.html +builddoc/_modules/mewpy/model/smoment.html +builddoc/_modules/mewpy/optimization/ea.html +builddoc/_modules/mewpy/optimization/inspyred/ea.html 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+builddoc/_static/css/fonts/lato-normal-italic.woff2 +builddoc/_static/css/fonts/lato-normal.woff +builddoc/_static/css/fonts/lato-normal.woff2 +builddoc/_static/css/fonts/Roboto-Slab-Bold.woff +builddoc/_static/css/fonts/Roboto-Slab-Bold.woff2 +builddoc/_static/css/fonts/Roboto-Slab-Regular.woff +builddoc/_static/css/fonts/Roboto-Slab-Regular.woff2 +builddoc/_static/js/badge_only.js +builddoc/_static/js/html5shiv-printshiv.min.js +builddoc/_static/js/html5shiv.min.js +builddoc/_static/js/theme.js diff --git a/docs/mewpy.cobra.rst b/docs/mewpy.cobra.rst new file mode 100644 index 00000000..261abd23 --- /dev/null +++ b/docs/mewpy.cobra.rst @@ -0,0 +1,37 @@ +mewpy.cobra package +=================== + +Submodules +---------- + +mewpy.cobra.medium module +------------------------- + +.. automodule:: mewpy.cobra.medium + :members: + :undoc-members: + :show-inheritance: + +mewpy.cobra.parsimonious module +------------------------------- + +.. automodule:: mewpy.cobra.parsimonious + :members: + :undoc-members: + :show-inheritance: + +mewpy.cobra.util module +----------------------- + +.. automodule:: mewpy.cobra.util + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.cobra + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.com.rst b/docs/mewpy.com.rst new file mode 100644 index 00000000..946ed43b --- /dev/null +++ b/docs/mewpy.com.rst @@ -0,0 +1,53 @@ +mewpy.com package +================= + +Submodules +---------- + +mewpy.com.analysis module +------------------------- + +.. automodule:: mewpy.com.analysis + :members: + :undoc-members: + :show-inheritance: + +mewpy.com.com module +-------------------- + +.. automodule:: mewpy.com.com + :members: + :undoc-members: + :show-inheritance: + +mewpy.com.regfba module +----------------------- + +.. automodule:: mewpy.com.regfba + :members: + :undoc-members: + :show-inheritance: + +mewpy.com.similarity module +--------------------------- + +.. automodule:: mewpy.com.similarity + :members: + :undoc-members: + :show-inheritance: + +mewpy.com.steadycom module +-------------------------- + +.. automodule:: mewpy.com.steadycom + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.com + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.germ.algebra.rst b/docs/mewpy.germ.algebra.rst new file mode 100644 index 00000000..daf8fbe2 --- /dev/null +++ b/docs/mewpy.germ.algebra.rst @@ -0,0 +1,53 @@ +mewpy.germ.algebra package +========================== + +Submodules +---------- + +mewpy.germ.algebra.algebra\_constants module +-------------------------------------------- + +.. automodule:: mewpy.germ.algebra.algebra_constants + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.algebra.algebra\_utils module +---------------------------------------- + +.. automodule:: mewpy.germ.algebra.algebra_utils + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.algebra.expression module +------------------------------------ + +.. automodule:: mewpy.germ.algebra.expression + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.algebra.parsing module +--------------------------------- + +.. automodule:: mewpy.germ.algebra.parsing + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.algebra.symbolic module +---------------------------------- + +.. automodule:: mewpy.germ.algebra.symbolic + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.germ.algebra + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.germ.analysis.rst b/docs/mewpy.germ.analysis.rst new file mode 100644 index 00000000..b44cb1b0 --- /dev/null +++ b/docs/mewpy.germ.analysis.rst @@ -0,0 +1,93 @@ +mewpy.germ.analysis package +=========================== + +Submodules +---------- + +mewpy.germ.analysis.analysis\_utils module +------------------------------------------ + +.. automodule:: mewpy.germ.analysis.analysis_utils + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.analysis.coregflux module +------------------------------------ + +.. automodule:: mewpy.germ.analysis.coregflux + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.analysis.fba module +------------------------------ + +.. automodule:: mewpy.germ.analysis.fba + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.analysis.integrated\_analysis module +----------------------------------------------- + +.. automodule:: mewpy.germ.analysis.integrated_analysis + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.analysis.metabolic\_analysis module +---------------------------------------------- + +.. automodule:: mewpy.germ.analysis.metabolic_analysis + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.analysis.pfba module +------------------------------- + +.. automodule:: mewpy.germ.analysis.pfba + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.analysis.prom module +------------------------------- + +.. automodule:: mewpy.germ.analysis.prom + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.analysis.regulatory\_analysis module +----------------------------------------------- + +.. automodule:: mewpy.germ.analysis.regulatory_analysis + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.analysis.rfba module +------------------------------- + +.. automodule:: mewpy.germ.analysis.rfba + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.analysis.srfba module +-------------------------------- + +.. automodule:: mewpy.germ.analysis.srfba + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.germ.analysis + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.germ.lp.rst b/docs/mewpy.germ.lp.rst new file mode 100644 index 00000000..c82301a8 --- /dev/null +++ b/docs/mewpy.germ.lp.rst @@ -0,0 +1,37 @@ +mewpy.germ.lp package +===================== + +Submodules +---------- + +mewpy.germ.lp.linear\_containers module +--------------------------------------- + +.. automodule:: mewpy.germ.lp.linear_containers + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.lp.linear\_problem module +------------------------------------ + +.. automodule:: mewpy.germ.lp.linear_problem + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.lp.linear\_utils module +---------------------------------- + +.. automodule:: mewpy.germ.lp.linear_utils + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.germ.lp + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.germ.models.rst b/docs/mewpy.germ.models.rst new file mode 100644 index 00000000..2b45ac20 --- /dev/null +++ b/docs/mewpy.germ.models.rst @@ -0,0 +1,45 @@ +mewpy.germ.models package +========================= + +Submodules +---------- + +mewpy.germ.models.metabolic module +---------------------------------- + +.. automodule:: mewpy.germ.models.metabolic + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.models.model module +------------------------------ + +.. automodule:: mewpy.germ.models.model + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.models.regulatory module +----------------------------------- + +.. automodule:: mewpy.germ.models.regulatory + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.models.serialization module +-------------------------------------- + +.. automodule:: mewpy.germ.models.serialization + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.germ.models + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.germ.rst b/docs/mewpy.germ.rst new file mode 100644 index 00000000..49b8a521 --- /dev/null +++ b/docs/mewpy.germ.rst @@ -0,0 +1,23 @@ +mewpy.germ package +================== + +Subpackages +----------- + +.. toctree:: + :maxdepth: 4 + + mewpy.germ.algebra + mewpy.germ.analysis + mewpy.germ.lp + mewpy.germ.models + mewpy.germ.solution + mewpy.germ.variables + +Module contents +--------------- + +.. automodule:: mewpy.germ + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.germ.solution.rst b/docs/mewpy.germ.solution.rst new file mode 100644 index 00000000..7fdef6be --- /dev/null +++ b/docs/mewpy.germ.solution.rst @@ -0,0 +1,37 @@ +mewpy.germ.solution package +=========================== + +Submodules +---------- + +mewpy.germ.solution.model\_solution module +------------------------------------------ + +.. automodule:: mewpy.germ.solution.model_solution + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.solution.multi\_solution module +------------------------------------------ + +.. automodule:: mewpy.germ.solution.multi_solution + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.solution.summary module +---------------------------------- + +.. automodule:: mewpy.germ.solution.summary + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.germ.solution + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.germ.variables.rst b/docs/mewpy.germ.variables.rst new file mode 100644 index 00000000..7675e191 --- /dev/null +++ b/docs/mewpy.germ.variables.rst @@ -0,0 +1,77 @@ +mewpy.germ.variables package +============================ + +Submodules +---------- + +mewpy.germ.variables.gene module +-------------------------------- + +.. automodule:: mewpy.germ.variables.gene + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.variables.interaction module +--------------------------------------- + +.. automodule:: mewpy.germ.variables.interaction + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.variables.metabolite module +-------------------------------------- + +.. automodule:: mewpy.germ.variables.metabolite + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.variables.reaction module +------------------------------------ + +.. automodule:: mewpy.germ.variables.reaction + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.variables.regulator module +------------------------------------- + +.. automodule:: mewpy.germ.variables.regulator + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.variables.target module +---------------------------------- + +.. automodule:: mewpy.germ.variables.target + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.variables.variable module +------------------------------------ + +.. automodule:: mewpy.germ.variables.variable + :members: + :undoc-members: + :show-inheritance: + +mewpy.germ.variables.variables\_utils module +-------------------------------------------- + +.. automodule:: mewpy.germ.variables.variables_utils + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.germ.variables + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.io.engines.rst b/docs/mewpy.io.engines.rst new file mode 100644 index 00000000..008f59d8 --- /dev/null +++ b/docs/mewpy.io.engines.rst @@ -0,0 +1,93 @@ +mewpy.io.engines package +======================== + +Submodules +---------- + +mewpy.io.engines.boolean\_csv module +------------------------------------ + +.. automodule:: mewpy.io.engines.boolean_csv + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.engines.co\_expression\_csv module +------------------------------------------- + +.. automodule:: mewpy.io.engines.co_expression_csv + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.engines.cobra\_model module +------------------------------------ + +.. automodule:: mewpy.io.engines.cobra_model + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.engines.engine module +------------------------------ + +.. automodule:: mewpy.io.engines.engine + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.engines.engines\_utils module +-------------------------------------- + +.. automodule:: mewpy.io.engines.engines_utils + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.engines.json module +---------------------------- + +.. automodule:: mewpy.io.engines.json + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.engines.metabolic\_sbml module +--------------------------------------- + +.. automodule:: mewpy.io.engines.metabolic_sbml + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.engines.reframed\_model module +--------------------------------------- + +.. automodule:: mewpy.io.engines.reframed_model + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.engines.regulatory\_sbml module +---------------------------------------- + +.. automodule:: mewpy.io.engines.regulatory_sbml + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.engines.target\_regulator\_csv module +---------------------------------------------- + +.. automodule:: mewpy.io.engines.target_regulator_csv + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.io.engines + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.io.rst b/docs/mewpy.io.rst index 25a7552a..5735b93a 100644 --- a/docs/mewpy.io.rst +++ b/docs/mewpy.io.rst @@ -1,37 +1,61 @@ mewpy.io package ================ +Subpackages +----------- + +.. toctree:: + :maxdepth: 4 + + mewpy.io.engines + Submodules ---------- -mewpy.io.bnet module --------------------- +mewpy.io.builder module +----------------------- -.. automodule:: mewpy.io.bnet +.. automodule:: mewpy.io.builder :members: :undoc-members: :show-inheritance: -mewpy.io.sbml module --------------------- +mewpy.io.director module +------------------------ -.. automodule:: mewpy.io.sbml +.. automodule:: mewpy.io.director :members: :undoc-members: :show-inheritance: -mewpy.io.sbml\_qual module --------------------------- +mewpy.io.dto module +------------------- -.. automodule:: mewpy.io.sbml_qual +.. automodule:: mewpy.io.dto :members: :undoc-members: :show-inheritance: -mewpy.io.tabular module ------------------------ +mewpy.io.reader module +---------------------- + +.. automodule:: mewpy.io.reader + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.sbml module +-------------------- + +.. automodule:: mewpy.io.sbml + :members: + :undoc-members: + :show-inheritance: + +mewpy.io.writer module +---------------------- -.. automodule:: mewpy.io.tabular +.. automodule:: mewpy.io.writer :members: :undoc-members: :show-inheritance: diff --git a/docs/mewpy.model.rst b/docs/mewpy.model.rst index b5d2447d..b4f5460e 100644 --- a/docs/mewpy.model.rst +++ b/docs/mewpy.model.rst @@ -20,6 +20,14 @@ mewpy.model.gecko module :undoc-members: :show-inheritance: +mewpy.model.kinetic module +-------------------------- + +.. automodule:: mewpy.model.kinetic + :members: + :undoc-members: + :show-inheritance: + mewpy.model.smoment module -------------------------- diff --git a/docs/mewpy.omics.integration.rst b/docs/mewpy.omics.integration.rst new file mode 100644 index 00000000..3a1f86a5 --- /dev/null +++ b/docs/mewpy.omics.integration.rst @@ -0,0 +1,37 @@ +mewpy.omics.integration package +=============================== + +Submodules +---------- + +mewpy.omics.integration.eflux module +------------------------------------ + +.. automodule:: mewpy.omics.integration.eflux + :members: + :undoc-members: + :show-inheritance: + +mewpy.omics.integration.gimme module +------------------------------------ + +.. automodule:: mewpy.omics.integration.gimme + :members: + :undoc-members: + :show-inheritance: + +mewpy.omics.integration.imat module +----------------------------------- + +.. automodule:: mewpy.omics.integration.imat + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.omics.integration + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.omics.rst b/docs/mewpy.omics.rst new file mode 100644 index 00000000..b7227c83 --- /dev/null +++ b/docs/mewpy.omics.rst @@ -0,0 +1,29 @@ +mewpy.omics package +=================== + +Subpackages +----------- + +.. toctree:: + :maxdepth: 4 + + mewpy.omics.integration + +Submodules +---------- + +mewpy.omics.expression module +----------------------------- + +.. automodule:: mewpy.omics.expression + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.omics + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.optimization.evaluation.rst b/docs/mewpy.optimization.evaluation.rst new file mode 100644 index 00000000..069eb78c --- /dev/null +++ b/docs/mewpy.optimization.evaluation.rst @@ -0,0 +1,45 @@ +mewpy.optimization.evaluation package +===================================== + +Submodules +---------- + +mewpy.optimization.evaluation.base module +----------------------------------------- + +.. automodule:: mewpy.optimization.evaluation.base + :members: + :undoc-members: + :show-inheritance: + +mewpy.optimization.evaluation.community module +---------------------------------------------- + +.. automodule:: mewpy.optimization.evaluation.community + :members: + :undoc-members: + :show-inheritance: + +mewpy.optimization.evaluation.evaluator module +---------------------------------------------- + +.. automodule:: mewpy.optimization.evaluation.evaluator + :members: + :undoc-members: + :show-inheritance: + +mewpy.optimization.evaluation.phenotype module +---------------------------------------------- + +.. automodule:: mewpy.optimization.evaluation.phenotype + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.optimization.evaluation + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.optimization.inspyred.rst b/docs/mewpy.optimization.inspyred.rst index 2e753b27..a1568cfc 100644 --- a/docs/mewpy.optimization.inspyred.rst +++ b/docs/mewpy.optimization.inspyred.rst @@ -36,6 +36,22 @@ mewpy.optimization.inspyred.problem module :undoc-members: :show-inheritance: +mewpy.optimization.inspyred.settings module +------------------------------------------- + +.. automodule:: mewpy.optimization.inspyred.settings + :members: + :undoc-members: + :show-inheritance: + +mewpy.optimization.inspyred.terminator module +--------------------------------------------- + +.. automodule:: mewpy.optimization.inspyred.terminator + :members: + :undoc-members: + :show-inheritance: + Module contents --------------- diff --git a/docs/mewpy.optimization.jmetal.rst b/docs/mewpy.optimization.jmetal.rst index bebd3417..84f2bc36 100644 --- a/docs/mewpy.optimization.jmetal.rst +++ b/docs/mewpy.optimization.jmetal.rst @@ -36,6 +36,14 @@ mewpy.optimization.jmetal.problem module :undoc-members: :show-inheritance: +mewpy.optimization.jmetal.settings module +----------------------------------------- + +.. automodule:: mewpy.optimization.jmetal.settings + :members: + :undoc-members: + :show-inheritance: + Module contents --------------- diff --git a/docs/mewpy.optimization.rst b/docs/mewpy.optimization.rst index d68d2f12..84c8d0c5 100644 --- a/docs/mewpy.optimization.rst +++ b/docs/mewpy.optimization.rst @@ -7,6 +7,7 @@ Subpackages .. toctree:: :maxdepth: 4 + mewpy.optimization.evaluation mewpy.optimization.inspyred mewpy.optimization.jmetal @@ -21,10 +22,10 @@ mewpy.optimization.ea module :undoc-members: :show-inheritance: -mewpy.optimization.evaluation module ------------------------------------- +mewpy.optimization.settings module +---------------------------------- -.. automodule:: mewpy.optimization.evaluation +.. automodule:: mewpy.optimization.settings :members: :undoc-members: :show-inheritance: diff --git a/docs/mewpy.problems.rst b/docs/mewpy.problems.rst index 320a760e..3a4ee083 100644 --- a/docs/mewpy.problems.rst +++ b/docs/mewpy.problems.rst @@ -4,6 +4,30 @@ mewpy.problems package Submodules ---------- +mewpy.problems.cofactor module +------------------------------ + +.. automodule:: mewpy.problems.cofactor + :members: + :undoc-members: + :show-inheritance: + +mewpy.problems.com module +------------------------- + +.. automodule:: mewpy.problems.com + :members: + :undoc-members: + :show-inheritance: + +mewpy.problems.etfl module +-------------------------- + +.. automodule:: mewpy.problems.etfl + :members: + :undoc-members: + :show-inheritance: + mewpy.problems.gecko module --------------------------- @@ -20,6 +44,38 @@ mewpy.problems.genes module :undoc-members: :show-inheritance: +mewpy.problems.hybrid module +---------------------------- + +.. automodule:: mewpy.problems.hybrid + :members: + :undoc-members: + :show-inheritance: + +mewpy.problems.kinetic module +----------------------------- + +.. automodule:: mewpy.problems.kinetic + :members: + :undoc-members: + :show-inheritance: + +mewpy.problems.optorf module +---------------------------- + +.. automodule:: mewpy.problems.optorf + :members: + :undoc-members: + :show-inheritance: + +mewpy.problems.optram module +---------------------------- + +.. automodule:: mewpy.problems.optram + :members: + :undoc-members: + :show-inheritance: + mewpy.problems.problem module ----------------------------- diff --git a/docs/mewpy.regulation.rst b/docs/mewpy.regulation.rst deleted file mode 100644 index 9abc52ee..00000000 --- a/docs/mewpy.regulation.rst +++ /dev/null @@ -1,85 +0,0 @@ -mewpy.regulation package -======================== - -Submodules ----------- - -mewpy.regulation.RFBA module ----------------------------- - -.. automodule:: mewpy.regulation.RFBA - :members: - :undoc-members: - :show-inheritance: - -mewpy.regulation.SRFBA module ------------------------------ - -.. automodule:: mewpy.regulation.SRFBA - :members: - :undoc-members: - :show-inheritance: - -mewpy.regulation.integrated\_model module ------------------------------------------ - -.. automodule:: mewpy.regulation.integrated_model - :members: - :undoc-members: - :show-inheritance: - -mewpy.regulation.optorf module ------------------------------- - -.. automodule:: mewpy.regulation.optorf - :members: - :undoc-members: - :show-inheritance: - -mewpy.regulation.optram module ------------------------------- - -.. automodule:: mewpy.regulation.optram - :members: - :undoc-members: - :show-inheritance: - -mewpy.regulation.regulatory\_interaction module ------------------------------------------------ - -.. automodule:: mewpy.regulation.regulatory_interaction - :members: - :undoc-members: - :show-inheritance: - -mewpy.regulation.regulatory\_model module ------------------------------------------ - -.. automodule:: mewpy.regulation.regulatory_model - :members: - :undoc-members: - :show-inheritance: - -mewpy.regulation.regulatory\_variable module --------------------------------------------- - -.. automodule:: mewpy.regulation.regulatory_variable - :members: - :undoc-members: - :show-inheritance: - -mewpy.regulation.variable module --------------------------------- - -.. automodule:: mewpy.regulation.variable - :members: - :undoc-members: - :show-inheritance: - -Module contents ---------------- - -.. automodule:: mewpy.regulation - :members: - :undoc-members: - :show-inheritance: diff --git a/docs/mewpy.rst b/docs/mewpy.rst index 62604c7e..35964fd2 100644 --- a/docs/mewpy.rst +++ b/docs/mewpy.rst @@ -7,13 +7,17 @@ Subpackages .. toctree:: :maxdepth: 4 + mewpy.cobra + mewpy.com + mewpy.germ mewpy.io mewpy.model + mewpy.omics mewpy.optimization mewpy.problems - mewpy.regulation mewpy.simulation - mewpy.utils + mewpy.solvers + mewpy.util mewpy.visualization Module contents diff --git a/docs/mewpy.simulation.rst b/docs/mewpy.simulation.rst index 1c30e92b..43bf6655 100644 --- a/docs/mewpy.simulation.rst +++ b/docs/mewpy.simulation.rst @@ -12,6 +12,38 @@ mewpy.simulation.cobra module :undoc-members: :show-inheritance: +mewpy.simulation.environment module +----------------------------------- + +.. automodule:: mewpy.simulation.environment + :members: + :undoc-members: + :show-inheritance: + +mewpy.simulation.germ module +---------------------------- + +.. automodule:: mewpy.simulation.germ + :members: + :undoc-members: + :show-inheritance: + +mewpy.simulation.hybrid module +------------------------------ + +.. automodule:: mewpy.simulation.hybrid + :members: + :undoc-members: + :show-inheritance: + +mewpy.simulation.kinetic module +------------------------------- + +.. automodule:: mewpy.simulation.kinetic + :members: + :undoc-members: + :show-inheritance: + mewpy.simulation.reframed module -------------------------------- @@ -20,6 +52,14 @@ mewpy.simulation.reframed module :undoc-members: :show-inheritance: +mewpy.simulation.sglobal module +------------------------------- + +.. automodule:: mewpy.simulation.sglobal + :members: + :undoc-members: + :show-inheritance: + mewpy.simulation.simulation module ---------------------------------- @@ -28,6 +68,14 @@ mewpy.simulation.simulation module :undoc-members: :show-inheritance: +mewpy.simulation.simulator module +--------------------------------- + +.. automodule:: mewpy.simulation.simulator + :members: + :undoc-members: + :show-inheritance: + Module contents --------------- diff --git a/docs/mewpy.solvers.rst b/docs/mewpy.solvers.rst new file mode 100644 index 00000000..c24bcbbb --- /dev/null +++ b/docs/mewpy.solvers.rst @@ -0,0 +1,93 @@ +mewpy.solvers package +===================== + +Submodules +---------- + +mewpy.solvers.cplex\_solver module +---------------------------------- + +.. automodule:: mewpy.solvers.cplex_solver + :members: + :undoc-members: + :show-inheritance: + +mewpy.solvers.gurobi\_solver module +----------------------------------- + +.. automodule:: mewpy.solvers.gurobi_solver + :members: + :undoc-members: + :show-inheritance: + +mewpy.solvers.ode module +------------------------ + +.. automodule:: mewpy.solvers.ode + :members: + :undoc-members: + :show-inheritance: + +mewpy.solvers.odespy\_solver module +----------------------------------- + +.. automodule:: mewpy.solvers.odespy_solver + :members: + :undoc-members: + :show-inheritance: + +mewpy.solvers.optlang\_solver module +------------------------------------ + +.. automodule:: mewpy.solvers.optlang_solver + :members: + :undoc-members: + :show-inheritance: + +mewpy.solvers.scikits\_solver module +------------------------------------ + +.. automodule:: mewpy.solvers.scikits_solver + :members: + :undoc-members: + :show-inheritance: + +mewpy.solvers.scipy\_solver module +---------------------------------- + +.. automodule:: mewpy.solvers.scipy_solver + :members: + :undoc-members: + :show-inheritance: + +mewpy.solvers.sglobal module +---------------------------- + +.. automodule:: mewpy.solvers.sglobal + :members: + :undoc-members: + :show-inheritance: + +mewpy.solvers.solution module +----------------------------- + +.. automodule:: mewpy.solvers.solution + :members: + :undoc-members: + :show-inheritance: + +mewpy.solvers.solver module +--------------------------- + +.. automodule:: mewpy.solvers.solver + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.solvers + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.util.rst b/docs/mewpy.util.rst new file mode 100644 index 00000000..c08f2435 --- /dev/null +++ b/docs/mewpy.util.rst @@ -0,0 +1,77 @@ +mewpy.util package +================== + +Submodules +---------- + +mewpy.util.constants module +--------------------------- + +.. automodule:: mewpy.util.constants + :members: + :undoc-members: + :show-inheritance: + +mewpy.util.crossmodel module +---------------------------- + +.. automodule:: mewpy.util.crossmodel + :members: + :undoc-members: + :show-inheritance: + +mewpy.util.graph module +----------------------- + +.. automodule:: mewpy.util.graph + :members: + :undoc-members: + :show-inheritance: + +mewpy.util.history module +------------------------- + +.. automodule:: mewpy.util.history + :members: + :undoc-members: + :show-inheritance: + +mewpy.util.parsing module +------------------------- + +.. automodule:: mewpy.util.parsing + :members: + :undoc-members: + :show-inheritance: + +mewpy.util.process module +------------------------- + +.. automodule:: mewpy.util.process + :members: + :undoc-members: + :show-inheritance: + +mewpy.util.request module +------------------------- + +.. automodule:: mewpy.util.request + :members: + :undoc-members: + :show-inheritance: + +mewpy.util.utilities module +--------------------------- + +.. automodule:: mewpy.util.utilities + :members: + :undoc-members: + :show-inheritance: + +Module contents +--------------- + +.. automodule:: mewpy.util + :members: + :undoc-members: + :show-inheritance: diff --git a/docs/mewpy.utils.rst b/docs/mewpy.utils.rst deleted file mode 100644 index 3bd27a45..00000000 --- a/docs/mewpy.utils.rst +++ /dev/null @@ -1,61 +0,0 @@ -mewpy.utils package -=================== - -Submodules ----------- - -mewpy.utils.constants module ----------------------------- - -.. automodule:: mewpy.utils.constants - :members: - :undoc-members: - :show-inheritance: - -mewpy.utils.crossmodel module ------------------------------ - -.. automodule:: mewpy.utils.crossmodel - :members: - :undoc-members: - :show-inheritance: - -mewpy.utils.graph module ------------------------- - -.. automodule:: mewpy.utils.graph - :members: - :undoc-members: - :show-inheritance: - -mewpy.utils.parsing module --------------------------- - -.. automodule:: mewpy.utils.parsing - :members: - :undoc-members: - :show-inheritance: - -mewpy.utils.process module --------------------------- - -.. automodule:: mewpy.utils.process - :members: - :undoc-members: - :show-inheritance: - -mewpy.utils.utilities module ----------------------------- - -.. automodule:: mewpy.utils.utilities - :members: - :undoc-members: - :show-inheritance: - -Module contents ---------------- - -.. automodule:: mewpy.utils - :members: - :undoc-members: - :show-inheritance: From 96c6583e912646547f7fbf985eb9a007f6cccee1 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 29 Jun 2024 21:42:34 +0100 Subject: [PATCH 12/24] add readthedocs yaml --- .readthedocs.yaml | 35 +++++++++++++++++++++++++++++++++++ 1 file changed, 35 insertions(+) create mode 100644 .readthedocs.yaml diff --git a/.readthedocs.yaml b/.readthedocs.yaml new file mode 100644 index 00000000..5dadbe9a --- /dev/null +++ b/.readthedocs.yaml @@ -0,0 +1,35 @@ +# Read the Docs configuration file for Sphinx projects +# See https://docs.readthedocs.io/en/stable/config-file/v2.html for details + +# Required +version: 2 + +# Set the OS, Python version and other tools you might need +build: + os: ubuntu-22.04 + tools: + python: "3.12" + # You can also specify other tool versions: + # nodejs: "20" + # rust: "1.70" + # golang: "1.20" + +# Build documentation in the "docs/" directory with Sphinx +sphinx: + configuration: docs/conf.py + # You can configure Sphinx to use a different builder, for instance use the dirhtml builder for simpler URLs + # builder: "dirhtml" + # Fail on all warnings to avoid broken references + # fail_on_warning: true + +# Optionally build your docs in additional formats such as PDF and ePub +# formats: +# - pdf +# - epub + +# Optional but recommended, declare the Python requirements required +# to build your documentation +# See https://docs.readthedocs.io/en/stable/guides/reproducible-builds.html +python: + install: + - requirements: docs/requirements.txt \ No newline at end of file From cfb45a0f6f1b51ba1c66aef57c3ef5540a00c895 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 29 Jun 2024 21:55:56 +0100 Subject: [PATCH 13/24] update docs requirements --- docs/requirements.txt | 4 +++- 1 file changed, 3 insertions(+), 1 deletion(-) diff --git a/docs/requirements.txt b/docs/requirements.txt index bfc3f807..88cf89bf 100644 --- a/docs/requirements.txt +++ b/docs/requirements.txt @@ -1 +1,3 @@ -nbsphinx \ No newline at end of file +nbsphinx +sphinx_rtd_theme +recommonmark \ No newline at end of file From f708998c45dda81639f08f0df96dc776cef7c1bf Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 14 Dec 2024 00:29:45 +0000 Subject: [PATCH 14/24] [UPDATE] parsing --- src/mewpy/util/parsing.py | 37 ++++++++++++++++++++++++++++++------- 1 file changed, 30 insertions(+), 7 deletions(-) diff --git a/src/mewpy/util/parsing.py b/src/mewpy/util/parsing.py index e8a10ed1..91faea7f 100644 --- a/src/mewpy/util/parsing.py +++ b/src/mewpy/util/parsing.py @@ -112,7 +112,7 @@ def paren(src: str) -> str: } # Operators precedence used to add parentesis when -# need as they are removed in the parsing tree +# needed as they are removed in the parsing tree MAX_PRECEDENCE = 10 latex_precedence = { "+": 0, @@ -365,7 +365,7 @@ def to_infix( cpar: str = ")", sep: str = " ", fsep: str = " , ", - replacers={S_AND: "and", S_OR: "or"}, + replacers=None, ) -> str: """Infix string representation @@ -380,9 +380,13 @@ def to_infix( :return: An infix string representation of the node :rtype: str """ - + + rep = {S_AND: "and", S_OR: "or", "^": "**"} + if replacers: + rep.update(replacers) + def rval(value): - return str(replacers[value]) if value in replacers.keys() else str(value) + return str(rep[value]) if value in rep.keys() else str(value) if self.is_leaf(): if self.value == EMPTY_LEAF: @@ -501,12 +505,17 @@ def arity(op): @staticmethod def replace(): return {} + + @staticmethod + def sub(op): + return op + class Arithmetic(Syntax): """Defines a basic arithmetic sintax.""" - operators = ["+", "-", "*", "/", "^"] + operators = ["+", "-", '**', "*", "/", "^"] @staticmethod def is_operator(op): @@ -527,6 +536,20 @@ def arity(op): ar = {"+": 2, "-": 2, "*": 2, "/": 2, "^": 2} return ar[op] + @staticmethod + def sub(op): + if op=='**': + return '^' + else: + return op + + @staticmethod + def rsub(op): + if op=='^': + return '**' + else: + return op + class ArithmeticEvaluator: @staticmethod @@ -807,7 +830,7 @@ def tokenize_infix_expression(exp: str, _exp = exp.replace("(", " ( ").replace(")", " ) ") if rules: for op in rules.operators: - _exp = _exp.replace(op, " " + op + " ") + _exp = _exp.replace(op, " " + rules.sub(op) + " ") tokens = _exp.split(" ") return list(filter(lambda x: x != "", tokens)) @@ -849,4 +872,4 @@ def split_or(node): raise ValueError(f"{exp} is a malformed expression") proteins = [node.to_infix(opar="", cpar="") for node in prots] - return proteins + return proteins \ No newline at end of file From a31b9112aba10bdd24f61a41d804f833ce2ef3ae Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 14 Dec 2024 23:47:43 +0000 Subject: [PATCH 15/24] [UPDATE] copasi function definitions support --- src/mewpy/io/sbml.py | 41 +++++++++++++++++++-- src/mewpy/model/kinetic.py | 74 ++++++++++++++++++++++++++++++++++---- src/mewpy/util/parsing.py | 70 +++++++++++++++++++++++++++--------- 3 files changed, 159 insertions(+), 26 deletions(-) diff --git a/src/mewpy/io/sbml.py b/src/mewpy/io/sbml.py index dde86140..0536a03f 100644 --- a/src/mewpy/io/sbml.py +++ b/src/mewpy/io/sbml.py @@ -22,8 +22,8 @@ from libsbml import AssignmentRule, SBMLReader -from ..model.kinetic import ODEModel, Compartment, Metabolite, KineticReaction, Rule - +from mewpy.model.kinetic import ODEModel, Compartment, Metabolite, KineticReaction, Rule +from mewpy.util.parsing import Node, EMPTY_LEAF def load_sbml(filename): """ Loads an SBML file. @@ -62,6 +62,7 @@ def load_ODEModel(filename): # load_reactions(sbml_model, ode_model) _load_concentrations(sbml_model, ode_model) _load_global_parameters(sbml_model, ode_model) + _load_functions(sbml_model, ode_model) _load_ratelaws(sbml_model, ode_model) _load_assignment_rules(sbml_model, ode_model) return ode_model @@ -174,7 +175,8 @@ def _load_ratelaws(sbml_model, odemodel): law = KineticReaction(reaction.getId(), formula, name=reaction.getName(), stoichiometry=stoichiometry, parameters=parameters, modifiers=modifiers, - reversible=reaction.getReversible()) + reversible=reaction.getReversible(), + functions = odemodel.function_definition) odemodel.set_ratelaw(reaction.getId(), law) @@ -183,3 +185,36 @@ def _load_assignment_rules(sbml_model, odemodel): if isinstance(rule, AssignmentRule): r_id = rule.getVariable() odemodel.set_assignment_rule(r_id, Rule(r_id, rule.getFormula())) + + +def travel(node): + if node.getNumChildren(): + + if node.isOperator(): + name = node.getCharacter() + else: + name = node.getName() + + r = travel(node.getRightChild()) + l = travel(node.getLeftChild()) + return Node(name,l,r) + else: + name = node.getName() + return Node(name,None,None) + +def _load_functions(sbml_model, odemodel): + functions = OrderedDict() + fd = sbml_model.getListOfFunctionDefinitions() + if not fd: + return + for function in fd: + fname = function.getName() + args = [] + for i in range(function.getNumArguments()): + arg = function.getArgument(i).getName() + args.append(arg) + body = function.getBody() + tree = travel(body) + functions[fname]=(args,tree) + + odemodel.set_functions(functions) \ No newline at end of file diff --git a/src/mewpy/model/kinetic.py b/src/mewpy/model/kinetic.py index a2edb543..01853d68 100644 --- a/src/mewpy/model/kinetic.py +++ b/src/mewpy/model/kinetic.py @@ -232,16 +232,19 @@ def __init__(self, stoichiometry: dict = {}, parameters: dict = {}, modifiers: list = [], - reversible: bool = True): + reversible: bool = True, + functions:dict={}): """Kinetic reaction rule. Args: r_id (str): Reaction identifier law (str): kinetic law - stoichiometry (dict): The stoichiometry of the reaction. - parameters (dict, optional): local parameters. Defaults to dict(). - substrates (list, optional): substrates. Defaults to []. - products (list, optional): products. Defaults to []. + name (str, optional): The name of the reaction. Defaults to None. + stoichiometry (dict, optional): The stoichiometry of the reaction. Defaults to {}. + parameters (dict, optional): local parameters. Defaults to {}. + modifiers (list, optional): modifiers. Defaults to []. + reversible (bool, optional): reversability. Defaults to True. + functions (dict, optional): function defined in the model. Defaults to {}. """ super(KineticReaction, self).__init__(r_id, law, parameters) self.name = name if name else r_id @@ -250,6 +253,20 @@ def __init__(self, self.parameter_distributions = {} self.reversible = reversible self._model = None + self.functions = {k:v[1] for k,v in functions.items()} + + + @property + def tree(self): + """Parsing tree of the law. + + Returns: + Node: Root node of the parsing tree. + """ + if not self._tree: + self._tree = build_tree(self.law, Arithmetic) + self._tree.replace_nodes(self.functions) + return self._tree @property def substrates(self): @@ -279,7 +296,7 @@ def sample_parameter(self, param): raise ValueError(f"The parameter {param} has no associated distribution.") return dist.rvs() - def parse_law(self, map: dict, local=True): + def parse_law(self, map: dict, functions=None, local=True): """Auxiliary method invoked by the model to build the ODE system. Args: @@ -292,6 +309,8 @@ def parse_law(self, map: dict, local=True): r_map = map.copy() r_map.update(m) + self + return self.replace(r_map, local=local) def calculate_rate(self, substrates={}, parameters={}): @@ -367,7 +386,8 @@ def __init__(self, model_id): # variable parameters self.variable_params = OrderedDict() self.assignment_rules = OrderedDict() - + self.function_definition = OrderedDict() + self._func_str = None self._constants = None self._m_r_lookup = None @@ -401,6 +421,9 @@ def add_metabolite(self, metabolite, replace=True): self.metabolites[metabolite.id] = metabolite + def set_functions(self, functions): + self.function_definition = functions + @property def reactions(self): return AttrDict(self.ratelaws) @@ -648,6 +671,43 @@ def find_parameters(self, pattern=None, sort=False): df = pd.DataFrame() return df + + def find_functions(self, pattern=None, sort=False): + """A user friendly method to find functions in the model. + + :param pattern: The pattern which can be a regular expression, + defaults to None in which case all entries are listed. + :type pattern: str, optional + :param sort: if the search results should be sorted, defaults to False + :type sort: bool, optional + :return: the search results + :rtype: pandas dataframe + """ + params = self.function_definition + values = list(params.keys()) + if pattern: + import re + if isinstance(pattern, list): + patt = '|'.join(pattern) + re_expr = re.compile(patt) + else: + re_expr = re.compile(pattern) + values = [x for x in values if re_expr.search(x) is not None] + if sort: + values.sort() + + import pandas as pd + data = [(x, ','.join(params[x][0]), str(params[x][1])) for x in values] + + if data: + df = pd.DataFrame(data, columns=['Name', 'Arguments','Body']) + df = df.set_index(df.columns[0]) + else: + df = pd.DataFrame() + return df + + + def deriv(self, t, y): """ Deriv function called by integrate. diff --git a/src/mewpy/util/parsing.py b/src/mewpy/util/parsing.py index 91faea7f..ad344eaa 100644 --- a/src/mewpy/util/parsing.py +++ b/src/mewpy/util/parsing.py @@ -27,6 +27,7 @@ from operator import add, sub, mul, truediv, pow import typing as T from math import * +from copy import copy # Boolean operator symbols S_AND = "&" @@ -231,18 +232,18 @@ def __init__( self.tp = tp def __repr__(self) -> str: - return self.__str__() - - # def _repr_latex_(self): - # return "$$ %s $$" % (self.to_latex()) - - def __str__(self) -> str: if self.is_leaf(): return str(self.value) else: return (f"{str(self.value)} " f"( {str(self.left)} ," f" {str(self.right)} )") + + # def _repr_latex_(self): + # return "$$ %s $$" % (self.to_latex()) + + def __str__(self) -> str: + return self.to_infix() def is_leaf(self) -> bool: """ @@ -317,6 +318,7 @@ def print_node(self, level=0): if self.right is not None: self.right.print_node(level + 1) + def evaluate(self, f_operand=None, f_operator=None): """ Evaluates the expression using the f_operand and @@ -359,6 +361,25 @@ def replace(self, r_map: dict): self.value, self.left.replace(r_map), self.right.replace(r_map), self.tp ) + def replace_node(self,value,node): + + if self.value is not None and self.value==value: + self.value = node.value + self.left = node.left.copy() + self.right = node.right.copy() + self.tp = node.tp + + elif not self.is_leaf(): + self.left.replace_node(value,node) + self.right.replace_node(value,node) + + else: + pass + + def replace_nodes(self,nodes:dict): + for k,v in nodes.items(): + self.replace_node(k,v) + def to_infix( self, opar: str = "(", @@ -393,14 +414,16 @@ def rval(value): return "" else: return rval(self.value) - elif self.tp == 2: + elif self.tp >=2: + op = opar if self.tp==2 else '' + cp = cpar if self.tp==2 else '' return "".join( [ rval(self.value), opar, - self.left.to_infix(opar, cpar, sep, fsep), + self.left.to_infix(op, cp, sep, fsep), fsep, - self.right.to_infix(opar, cpar, sep, fsep), + self.right.to_infix(op, cp, sep, fsep), cpar, ] ) @@ -471,9 +494,9 @@ def to_latex(self) -> T.Tuple[str, int]: def copy(self): if self.is_leaf(): - return Node(self.value.copy(), None, None) + return Node(copy(self.value), None, None) else: - return Node(self.value.copy(), self.left.copy(), self.right.copy(), self.tp) + return Node(copy(self.value), self.left.copy(), self.right.copy(), self.tp) class Syntax: @@ -713,6 +736,17 @@ def tokenize_function(exp: str) -> T.List[str]: else: return tokens +def list2tree(values, rules): + if len(values)==0: + return Node(EMPTY_LEAF) + elif len(values)==1: + return build_tree(values[0], rules) + else: + return Node(',', + build_tree(values[0], rules), + list2tree(values[1:],rules)) + + # Tree def build_tree(exp: str, rules: Syntax) -> Node: @@ -758,14 +792,18 @@ def build_tree(exp: str, rules: Syntax) -> Node: else: if "(" in token: f = tokenize_function(token) - if len(f) == 2: - t = Node(f[0], Node(EMPTY_LEAF), build_tree(f[1], rules), 1) - elif len(f) == 3: + fname = f[0] + params = f[1:] + if len(params) == 1: + t = Node(fname, Node(EMPTY_LEAF), build_tree(params[0], rules), 1) + elif len(params) == 2: t = Node( - f[0], build_tree(f[1], rules), build_tree(f[2], rules), 2 + fname, build_tree(params[0], rules), build_tree(params[1], rules), 2 ) else: - t = Node(token) + t = Node( + fname, build_tree(params[0], rules), list2tree(params[1:],rules) , len(f)-1 + ) else: t = Node(token) tree_stack.append(t) From d197ecbe399ad1c9038740c7e9e34c0f2cf7e5b5 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sat, 14 Dec 2024 23:48:10 +0000 Subject: [PATCH 16/24] [ADD] example --- .../10-Ecoli&Yeast-Tyrosine dependent.ipynb | 1042 + examples/models/ec/iAF1260.xml | 64086 ++++++++++++++++ 2 files changed, 65128 insertions(+) create mode 100644 examples/10-Ecoli&Yeast-Tyrosine dependent.ipynb create mode 100644 examples/models/ec/iAF1260.xml diff --git a/examples/10-Ecoli&Yeast-Tyrosine dependent.ipynb b/examples/10-Ecoli&Yeast-Tyrosine dependent.ipynb new file mode 100644 index 00000000..68f9aab4 --- /dev/null +++ b/examples/10-Ecoli&Yeast-Tyrosine dependent.ipynb @@ -0,0 +1,1042 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "964f21d0", + "metadata": {}, + "source": [ + "# Escherichia coli and Saccharomices cerevisiae co-culture\n", + "\n", + "The notebook illustrates how to \n", + "- construct a community model representing the co-culture of Escherichia coli and Saccharomices cerevisiae from models of each single organism,\n", + "- run FBA on the community model\n", + "- optimize the co-culture for the production of a naringenin." + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "id": "671b4784", + "metadata": {}, + "outputs": [], + "source": [ + "from cobra.io import read_sbml_model\n", + "\n", + "from mewpy.optimization import EA\n", + "from mewpy.optimization.evaluation import TargetFlux, BPCY\n", + "from mewpy.problems import RKOProblem\n", + "from mewpy import get_simulator\n", + "from mewpy.com import *" + ] + }, + { + "cell_type": "markdown", + "id": "744898e7", + "metadata": {}, + "source": [ + "## Load individual organism model" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "230f1c74", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Set parameter Username\n", + "Academic license - for non-commercial use only - expires 2024-12-11\n" + ] + }, + { + "name": "stderr", + "output_type": "stream", + "text": [ + "No objective coefficients in model. Unclear what should be optimized\n" + ] + } + ], + "source": [ + "sc = read_sbml_model('models/yeast/iMM904.xml.gz')\n", + "ec = read_sbml_model('models/ec/iAF1260.xml')\n", + "get_simulator(ec).objective='BIOMASS'" + ] + }, + { + "cell_type": "markdown", + "id": "7ee03f89", + "metadata": {}, + "source": [ + "# Community Model and Medium" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "46a6450f", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "Organism: 0%| | 0/2 [00:00\n", + "\n", + "\n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + " \n", + "
Value
Reaction
R_EX_tyr__L_e_iAF1260-0.057137
R_EX_tyr__L_e_iMM9040.057137
R_EX_tyr__L_e-0.000000
\n", + "" + ], + "text/plain": [ + " Value\n", + "Reaction \n", + "R_EX_tyr__L_e_iAF1260 -0.057137\n", + "R_EX_tyr__L_e_iMM904 0.057137\n", + "R_EX_tyr__L_e -0.000000" + ] + }, + "execution_count": 7, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "res.get_metabolite('M_tyr__L_e')" + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "id": "c54dda6d", + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "{'R_EX_tyr__L_e_iAF1260': [-0.06201572827296663, 0.4629281063033095],\n", + " 'R_EX_tyr__L_e_iMM904': [-0.46292810649603566, 0.062015728275737037]}" + ] + }, + "execution_count": 8, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "cmodel.FVA(reactions=['R_EX_tyr__L_e_iAF1260','R_EX_tyr__L_e_iMM904'])" + ] + }, + { + "cell_type": "markdown", + "id": "eb3d0ccb", + "metadata": {}, + "source": [ + "## Optimization" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "d3e3b08c", + "metadata": {}, + "outputs": [], + "source": [ + "TARGET = 'R_EX_tyr__L_e_iAF1260'" + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "id": "08757ac8", + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "'community_growth'" + ] + }, + "execution_count": 11, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "BIOMASS = list(cmodel.objective.keys())[0]\n", + "BIOMASS" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "ef387529", + "metadata": {}, + "outputs": [], + "source": [ + "f1 = BPCY(BIOMASS,TARGET)\n", + "f2 = TargetFlux(TARGET)" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "fb9dedf8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "100%|██████████████████████████████████████████████████████████████████| 4320/4320 [06:58<00:00, 10.32it/s]\n" + ] + } + ], + "source": [ + "essential = cmodel.essential_reactions()" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "52d72fd4", + "metadata": {}, + "outputs": [], + "source": [ + "KO_targets = []\n", + "\n", + "for rxn in cmodel.reactions:\n", + " if rxn.endswith('iAF1260') and rxn not in essential:\n", + " if (rxn == 'R_ATPM_iAF1260'\n", + " or rxn.startswith('R_EX_') \n", + " or rxn.startswith('R_ATPS')\n", + " or rxn.endswith('tex_iAF1260')\n", + " or rxn.endswith('pp_iAF1260')\n", + " or rxn.endswith('exi_iAF1260')):\n", + " continue\n", + " else:\n", + " KO_targets.append(rxn)" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "1738198b", + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "1038" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "len(KO_targets)" + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "id": "5c7994cd", + "metadata": {}, + "outputs": [], + "source": [ + "problem = RKOProblem(cmodel, \n", + " fevaluation=[f1,f2],\n", + " target=KO_targets,\n", + " candidate_max_size=2)\n", + "\n", + "ea = EA(problem, max_generations = 10)" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "e5a3d000", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Running NSGAII\n", + "Eval(s)| Worst Best Median Average Std Dev| Worst Best Median Average Std Dev|\n", + " 100| -0.023636 -0.022767 -0.023636 -0.023596 0.000149| -0.057137 -0.056078 -0.057137 -0.057089 0.000181|\n", + " 200| -0.023636 -0.022767 -0.023636 -0.023579 0.000167| -0.057137 -0.056078 -0.057137 -0.057068 0.000203|\n", + " 300| -0.023636 -0.022746 -0.023614 -0.023511 0.000222| -0.057137 -0.056051 -0.057111 -0.056985 0.000271|\n", + " 400| -0.023601 -0.022582 -0.023396 -0.023312 0.000289| -0.057095 -0.055849 -0.056847 -0.056743 0.000352|\n", + " 500| -0.023167 -0.015257 -0.023053 -0.022875 0.000788| -0.056568 -0.037559 -0.056428 -0.056117 0.001879|\n", + " 600| 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"ea.run(simplify=False)" + ] + }, + { + "cell_type": "code", + "execution_count": 18, + "id": "aa6f0b3b", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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ModificationMSizeBPCYTargetFlux
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Flux rate
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iAF1260iMM904Total Net
Metabolite
M_pro__L_e-0.0901630.0901630.00000
M_mobd_e-0.0012880.000000-0.00129
M_cl_e-0.0019320.000000-0.00193
M_asn__L_e0.041472-0.0414720.00000
M_cobalt2_e-0.0012880.000000-0.00129
M_orn_e-0.1861570.1861570.00000
M_h2o_e22.69901811.55166734.25068
M_co2_e10.1618338.48228618.64412
M_fum_e-14.16909414.1690940.00000
M_cu_e-0.0012880.000000-0.00129
M_met__L_e-0.0627690.0627690.00000
M_mn2_e-0.0012880.000000-0.00129
M_phe__L_e-0.0717310.0717310.00000
M_hxan_e-6.7537136.7537130.00000
M_pi_e-0.392017-0.080620-0.47264
M_thr__L_e-0.2303370.2303370.00000
M_acald_e0.373422-0.3734220.00000
M_ins_e6.753713-6.7537130.00000
M_ile__L_e0.038219-0.0382190.00000
M_mg2_e-0.0032200.000000-0.00322
M_for_e-0.0021080.0021080.00000
M_gua_e0.014300-0.0143000.00000
M_succ_e14.169094-14.1690940.00000
M_fe3_e-0.0059770.000000-0.00598
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M_his__L_e0.027037-0.0270370.00000
M_akg_e0.509536-0.5095360.00000
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M_ura_e0.045102-0.0451020.00000
M_etoh_e-7.5670707.5670700.00000
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CHARGE: -3

+ + + + + + +

FORMULA: C3H7NO2S

+

CHARGE: 0

+ + + + + + +

FORMULA: N2O

+

CHARGE: 0

+ + + + + + +

FORMULA: C20H40O9P1

+

CHARGE: -1

+ + + + + + +

FORMULA: C3H5NO4S

+

CHARGE: -2

+ + + + + + +

FORMULA: C14H18N2O16P2

+

CHARGE: -2

+ + + + + + +

FORMULA: C7H13O10P

+

CHARGE: -2

+ + + + + + +

FORMULA: C6H13NO2

+

CHARGE: 0

+ + + + + + +

FORMULA: C68H95CoN21O21P2

+

CHARGE: -1

+ + + + + + +

FORMULA: C6H8N3O4P

+

CHARGE: -2

+ + + + + + +

FORMULA: C6H10O5

+

CHARGE: 0

+ + + + + + +

FORMULA: C19H29N2O12

+

CHARGE: -1

+ + + + + + +

FORMULA: C10H11N4O11P2

+

CHARGE: -3

+ + + + + + +

FORMULA: C5H6NO2

+

CHARGE: -1

+ + + + + + +

FORMULA: C5H8O11P2

+

CHARGE: -4

+ + + + + + +

FORMULA: C12H13NO9P

+

CHARGE: -3

+ + + + + + +

FORMULA: C39H64N7O18P3S

+

CHARGE: -4

+ + + + + + +

FORMULA: C5H9O8P

+

CHARGE: -2

+ + + + + + +

FORMULA: C14H22N2O10PRS

+

CHARGE: -2

+ + + + + + +

FORMULA: C3H5O6P

+

CHARGE: -2

+ + + + + + +

FORMULA: C6H5O7

+

CHARGE: -3

+ + + + + + +

FORMULA: RHO

+

CHARGE: 0

+ + + + + + +

FORMULA: C20H24N10O19P4

+

CHARGE: -4

+ + + + + + +

FORMULA: C34H38N4O4

+

CHARGE: -2

+ + + + + + +

FORMULA: C2H4NOR

+

CHARGE: 1

+ + + + + + +

FORMULA: C35H58N7O18P3S

+

CHARGE: -4

+ + + + + + +

FORMULA: C27H49N2O8PRS

+

CHARGE: -1

+ + + + + + +

FORMULA: C10H12N5O9P2

+

CHARGE: -3

+ + + + + + +

FORMULA: C28H41N7O19P3S

+

CHARGE: -5

+ + + + + + +

FORMULA: C6H11O2

+

CHARGE: -1

+ + + + + + +

FORMULA: R

+

CHARGE: 0

+ + + + + + +

FORMULA: C11H8O5

+

CHARGE: -2

+ + + + + + +

FORMULA: CH3O3S

+

CHARGE: -1

+ + + + + + +

FORMULA: C4H4N2O2

+

CHARGE: 0

+ + + + + + +

FORMULA: C17H25N3O17P2

+

CHARGE: -2

+ + + + + + +

FORMULA: C16H26N3O14P2

+

CHARGE: -1

+ + + + + + +

FORMULA: C72H100CoN18O17P

+

CHARGE: 0

+ + + + + + +

FORMULA: C31H59O8P1

+

CHARGE: -2

+ + + + + + +

FORMULA: C26H40N7O26P5S

+

CHARGE: -6

+ + + + + + +

FORMULA: C10H11N5O10P2

+

CHARGE: -4

+ + + + + + +

FORMULA: C114H202N2O39P2

+

CHARGE: -6

+ + + + + + +

FORMULA: C9H11O4

+

CHARGE: -1

+ + + + + + +

FORMULA: R

+

CHARGE: 0

+ + + + + + +

FORMULA: C10H10NO6Fe

+

CHARGE: 2

+ + + + + + +

FORMULA: C4H14N2

+

CHARGE: 2

+ + + + + + +

FORMULA: C12H16N4O4PS

+

CHARGE: -1

+ + + + + + +

FORMULA: C9H9O4

+

CHARGE: -1

+ + + + + + +

FORMULA: C27H47N2O9PRS

+

CHARGE: -1

+ + + + + + +

FORMULA: C60H110O11P

+

CHARGE: -1

+ + + + + + +

FORMULA: Ag

+

CHARGE: 1

+ + + + + + +

FORMULA: C6H11O9P

+

CHARGE: -2

+ + + + + + +

FORMULA: C25H47N2O9PRS

+

CHARGE: -1

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurF

+

PROTEIN_CLASS: 2.4.2.14

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Dos

+

PROTEIN_CLASS: 3.1.4.17

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: WecB

+

PROTEIN_CLASS: 5.1.3.14

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( XapA ) or ( DeoD )

+

PROTEIN_CLASS: 2.4.2.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XapA

+

PROTEIN_CLASS: 2.4.2.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( XapA ) or ( DeoD )

+

PROTEIN_CLASS: 2.4.2.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( XapA ) or ( DeoD )

+

PROTEIN_CLASS: 2.4.2.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MmuM

+

PROTEIN_CLASS: 2.1.1.10

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MetG

+

PROTEIN_CLASS: 6.1.1.10

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CobU

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GshA

+

PROTEIN_CLASS: 6.3.2.2

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tsx

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( Slt ) or ( MltA ) or ( MltB ) or ( MltE ) or ( MltC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Psd

+

PROTEIN_CLASS: 4.1.1.65

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabA ) or ( FabZ )

+

PROTEIN_CLASS: 4.2.1.58

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DeoD

+

PROTEIN_CLASS: 2.4.2.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( XapA ) or ( DeoD )

+

PROTEIN_CLASS: 2.4.2.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DeoD

+

PROTEIN_CLASS: 2.4.2.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NadA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PrpB

+

PROTEIN_CLASS: 4.1.3.30

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Psd

+

PROTEIN_CLASS: 4.1.1.65

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( BtuC and BtuD and BtuF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DacB ) or ( MepA ) or ( PbpG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaR

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LpxP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaO

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: RhaA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Cof ) or ( YmfB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RhaT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CycAec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FhuE and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AstA

+

PROTEIN_CLASS: 2.3.1.109

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LpxL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ArsC and GrxB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NarKec ) or ( NarU )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NupG ) or ( NupCec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HemBec

+

PROTEIN_CLASS: 4.2.1.24

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AmiB ) or ( AmiA ) or ( AmiC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CbdAB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XapB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MhpF ) or ( AdhE )

+

PROTEIN_CLASS: 1.2.1.10

+

SUBSYSTEM: S_Pyruvate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DadA

+

PROTEIN_CLASS: 1.4.99.1

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabA ) or ( FabZ )

+

PROTEIN_CLASS: 4.2.1.58

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Apt

+

PROTEIN_CLASS: 2.4.2.7

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpB ) or ( PgpA )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LldP ) or ( GlcA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlnS

+

PROTEIN_CLASS: 6.1.1.18

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DppA and DppB and DppC and DppD and DppF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MgsA

+

PROTEIN_CLASS: 4.2.3.3

+

SUBSYSTEM: S_Methylglyoxal_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Psd

+

PROTEIN_CLASS: 4.1.1.65

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LeuA

+

PROTEIN_CLASS: 4.1.3.12

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Psd

+

PROTEIN_CLASS: 4.1.1.65

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IlvCec

+

PROTEIN_CLASS: 1.1.1.86

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AspC

+

PROTEIN_CLASS: 2.6.1.1

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ClcA ) or ( ClcB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UxuB

+

PROTEIN_CLASS: 1.1.1.57

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( WzyE and WzzE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CysH and TrxC ) or ( CysH and TrxA )

+

PROTEIN_CLASS: 1.8.4.8

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LytB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GalM

+

PROTEIN_CLASS: 5.1.3.3

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: GlyQS

+

PROTEIN_CLASS: 6.1.1.14

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 2.7.1.100

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MalE and MalF and MalG and MalK )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BioBec

+

PROTEIN_CLASS: 2.8.1.6

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 5.3.1.23

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YcdG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RhaB

+

PROTEIN_CLASS: 2.7.1.5

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RhaA

+

PROTEIN_CLASS: 5.3.1.14

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CaiD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CodA

+

PROTEIN_CLASS: 3.5.4.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CobS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DapD

+

PROTEIN_CLASS: 2.3.1.117

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IlvCec

+

PROTEIN_CLASS: 1.1.1.86

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Psd

+

PROTEIN_CLASS: 4.1.1.65

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TrpS

+

PROTEIN_CLASS: 6.1.1.2

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UxaA

+

PROTEIN_CLASS: 4.2.1.7

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: SerS

+

PROTEIN_CLASS: 6.1.1.11

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ProS

+

PROTEIN_CLASS: 6.1.1.15

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabA ) or ( FabZ )

+

PROTEIN_CLASS: 4.2.1.58

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CysC

+

PROTEIN_CLASS: 2.7.1.25

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Add

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Fdoec ) or ( Fdn )

+

PROTEIN_CLASS: 1.2.2.1

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MenD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurA

+

PROTEIN_CLASS: 6.3.4.4

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MetB

+

PROTEIN_CLASS: 4.2.99.9

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Adk

+

PROTEIN_CLASS: 2.7.4.11

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FucA ) or ( YgbL )

+

PROTEIN_CLASS: 4.1.2.17

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UshA ) or ( AphA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AcpH

+

PROTEIN_CLASS: 3.1.2.14

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: YjjX

+

PROTEIN_CLASS: 3.6.1.15

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YjjX ) or ( YjeQ )

+

PROTEIN_CLASS: 3.6.1.15

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( RpiA ) or ( RpiB )

+

PROTEIN_CLASS: 5.3.1.6

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YjjX

+

PROTEIN_CLASS: 3.6.1.15

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DsbD and TrxA ) or ( DsbD and TrxC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LivF and LivG and LivH and LivJ and LivM )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( Rpeec ) or ( SgcE )

+

PROTEIN_CLASS: 5.1.3.1

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TrpDec and TrpEec )

+

PROTEIN_CLASS: 4.1.3.27

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CaiD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AraD ) or ( SgaE ) or ( SgbE )

+

PROTEIN_CLASS: 5.1.3.4

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZntA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( GlpX ) or ( Fbp )

+

PROTEIN_CLASS: 3.1.3.11

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FocA ) or ( FocB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PstA and PstB and PstC and PstD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FucI

+

PROTEIN_CLASS: 5.3.1.25

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GltX

+

PROTEIN_CLASS: 6.1.1.17

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HemA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GldA

+

PROTEIN_CLASS: 1.1.1.6

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgoD

+

PROTEIN_CLASS: 4.2.1.6

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tam

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DacA ) or ( DacB ) or ( DacC ) or ( DacD )

+

PROTEIN_CLASS: 3.4.16.4

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( KefB ) or ( KefC ) or ( ChaA ) or ( MdfA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AmpD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Adk

+

PROTEIN_CLASS: 2.7.4.3

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IspA

+

PROTEIN_CLASS: 2.5.1.10

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NagZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FbaB ) or ( B1773 ) or ( FbaA )

+

PROTEIN_CLASS: 4.1.2.13

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GloB

+

PROTEIN_CLASS: 3.1.2.6

+

SUBSYSTEM: S_Methylglyoxal_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AcpP and FabHec )

+

PROTEIN_CLASS: 2.3.1.38

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Adk

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Adk

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RibDec

+

PROTEIN_CLASS: 1.1.1.193

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( RelA ) or ( SpoT )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FieF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS: 5.3.3.7

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GcpE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CpdB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: GapA

+

PROTEIN_CLASS: 1.2.1.12

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: GalUec

+

PROTEIN_CLASS: 2.7.7.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DppA and DppB and DppC and DppD and DppF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: HemG

+

PROTEIN_CLASS: 1.3.3.4

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SerB

+

PROTEIN_CLASS: 3.1.3.3

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ZitB ) or ( FieF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.1.3.10

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YbiV

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ManX and ManY and ManZ and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GdhA

+

PROTEIN_CLASS: 1.4.1.4

+

SUBSYSTEM: S_Glutamate_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: WaaB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LeuB

+

PROTEIN_CLASS: 1.1.1.85

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MenA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Dcd

+

PROTEIN_CLASS: 3.5.4.13

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GadA ) or ( GadB )

+

PROTEIN_CLASS: 4.1.1.15

+

SUBSYSTEM: S_Glutamate_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadD ) or ( FadK )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpA ) or ( PgpB )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GltS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tmk

+

PROTEIN_CLASS: 2.7.4.9

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AldA

+

PROTEIN_CLASS: 1.2.1.21

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HmpA

+

PROTEIN_CLASS: 1.14.12.17

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SsuA and SsuB and SsuC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SucCD

+

PROTEIN_CLASS: 6.2.1.5

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GlpA ) or ( GlpD )

+

PROTEIN_CLASS: 1.1.99.5

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MmuM

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: GlpA

+

PROTEIN_CLASS: 1.1.99.5

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpA

+

PROTEIN_CLASS: 1.1.99.5

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FolE

+

PROTEIN_CLASS: 3.5.4.16

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GpsA

+

PROTEIN_CLASS: 1.1.1.94

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: AcpH

+

PROTEIN_CLASS: 3.1.2.14

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Gph

+

PROTEIN_CLASS: 3.1.3.18

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YiaM and YiaN and YiaO )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MelA

+

PROTEIN_CLASS: 3.2.1.22

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadK ) or ( FadD )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PutPec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TrpCec

+

PROTEIN_CLASS: 5.3.1.24

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GrxC ) or ( GrxA ) or ( GrxD ) or ( GrxB )

+

PROTEIN_CLASS: 1.8.4.2

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GmhB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: EntB

+

PROTEIN_CLASS: 3.3.2.1

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SelD

+

PROTEIN_CLASS: 2.7.9.3

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mpl

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpA ) or ( PgpB )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpA ) or ( PgpB )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GarK

+

PROTEIN_CLASS: 2.7.1.31

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurM

+

PROTEIN_CLASS: 6.3.3.1

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: OtsA

+

PROTEIN_CLASS: 2.4.1.15

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CysA and CysU and CysW and Sbp ) or ( ModA and ModB and ModC ) or ( CysA and CysP and CysU and CysW )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WzxB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: OtsB

+

PROTEIN_CLASS: 3.1.3.12

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MenF

+

PROTEIN_CLASS: 5.4.99.6

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UbiG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PotA and PotB and PotC and PotDec ) or ( YdcS and YdcT and YdcU and YdcV )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TreC

+

PROTEIN_CLASS: 3.2.1.93

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NadB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NadB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AphA ) or ( UshA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MurA

+

PROTEIN_CLASS: 2.5.1.7

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NadB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( TorYZ ) or ( TorCA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NadB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Cls ) or ( YbhO )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Psd

+

PROTEIN_CLASS: 4.1.1.65

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Psd

+

PROTEIN_CLASS: 4.1.1.65

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CusCFBA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HmpA

+

PROTEIN_CLASS: 1.14.12.17

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YjjN

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DcuB ) or ( DcuC ) or ( DcuA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArnT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NanT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UbiE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GltP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThrS

+

PROTEIN_CLASS: 6.1.1.3

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CysA and CysP and CysU and CysW ) or ( CysA and CysU and CysW and Sbp )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: NrfABCD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurDec

+

PROTEIN_CLASS: 6.3.4.13

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpA ) or ( PgpB )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpA ) or ( PgpB )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CynX

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RdgB

+

PROTEIN_CLASS: 3.6.1.19

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RdgB

+

PROTEIN_CLASS: 3.6.1.19

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.4.17.13

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: AlaS

+

PROTEIN_CLASS: 6.1.1.7

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ProA

+

PROTEIN_CLASS: 1.2.1.41

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GalT

+

PROTEIN_CLASS: 2.7.7.12

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YcdW ) or ( YiaE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YiaE ) or ( YcdW )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CycAec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CydC and CydD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabB ) or ( FabF )

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UgpA and UgpB and UgpC and UgpE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabB

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SsuE ) or ( CysIJ ) or ( Fre )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tdh

+

PROTEIN_CLASS: 1.1.1.103

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Ndh

+

PROTEIN_CLASS: 1.6.5.3

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MalE and MalF and MalG and MalK )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Gsk

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cfa

+

PROTEIN_CLASS: 2.1.1.79

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpB ) or ( PgpA )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: GlmMec

+

PROTEIN_CLASS: 5.4.2.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpA ) or ( PgpB )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DapE

+

PROTEIN_CLASS: 3.5.1.18

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GarP ) or ( GudP )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AstB

+

PROTEIN_CLASS: 2.6.1.69

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YedO

+

PROTEIN_CLASS: 4.4.1.15

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PepD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GlyA ) or ( LtaE )

+

PROTEIN_CLASS: 4.1.2.5

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RfaD

+

PROTEIN_CLASS: 5.1.3.20

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MhpC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabB ) or ( FabF )

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GalK ) or ( WcaK )

+

PROTEIN_CLASS: 2.7.1.6

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabHec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PbpC ) or ( MrcB ) or ( MrcA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MurGec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabB ) or ( FabF )

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Cfa

+

PROTEIN_CLASS: 2.1.1.79

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PdxK

+

PROTEIN_CLASS: 2.7.1.35

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlmUec

+

PROTEIN_CLASS: 2.7.7.23

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YbiV

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YicE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CpdB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CdsA

+

PROTEIN_CLASS: 2.7.7.41

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: SgaU

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LdcA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CdsA

+

PROTEIN_CLASS: 2.7.7.41

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LivF and LivG and LivH and LivJ and LivM )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GsiA and GsiB and GsiC and GsiD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( ManX and ManY and ManZ and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AcpH

+

PROTEIN_CLASS: 3.1.2.14

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( BtuB and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AraA

+

PROTEIN_CLASS: 5.3.1.4

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WzxE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( Rfc and WzzB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlxK

+

PROTEIN_CLASS: 2.7.1.31

+

SUBSYSTEM: S_Glyoxylate_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tsx

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ProVec and ProW and ProX )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PyrBec

+

PROTEIN_CLASS: 2.1.3.2

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LamB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GcvH and GcvP and GcvT and LpdA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Folate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Ugd

+

PROTEIN_CLASS: 1.1.1.22

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UbiA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.4.17.13

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UhpT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 2.1.3.5

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThrC

+

PROTEIN_CLASS: 4.2.3.1

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MurD

+

PROTEIN_CLASS: 6.3.2.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CdsA

+

PROTEIN_CLASS: 2.7.7.41

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CdsA

+

PROTEIN_CLASS: 2.7.7.41

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UxaB

+

PROTEIN_CLASS: 1.1.1.58

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: LpxD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Methylglyoxal_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadD ) or ( FadK )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FldA and Fpr ) or ( FldB and Fpr )

+

PROTEIN_CLASS: 1.18.1.2

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PanD

+

PROTEIN_CLASS: 4.1.1.11

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FdhF and Hyd4 ) or ( FdhF and HycB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Pyruvate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NadD

+

PROTEIN_CLASS: 2.7.7.18

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Kbl

+

PROTEIN_CLASS: 2.3.1.29

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpA ) or ( PgpB )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CdsA

+

PROTEIN_CLASS: 2.7.7.41

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PrpE

+

PROTEIN_CLASS: 6.2.1.13

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CitG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( BtuB and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CdsA

+

PROTEIN_CLASS: 2.7.7.41

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 1.1.1.77

+

SUBSYSTEM: S_Methylglyoxal_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SseA

+

PROTEIN_CLASS: 2.8.1.2

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FucO

+

PROTEIN_CLASS: 1.1.1.77

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgoT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.1.3.7

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( BetT ) or ( YeaV )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Fsa ) or ( TalC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Car

+

PROTEIN_CLASS: 6.3.5.5

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CpdB

+

PROTEIN_CLASS: 3.1.4.16

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SstT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CysA and CysP and CysU and CysW ) or ( ModA and ModB and ModC ) or ( CysA and CysU and CysW and Sbp )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Ndh

+

PROTEIN_CLASS: 1.6.5.3

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Ndh

+

PROTEIN_CLASS: 1.6.5.3

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PaaK

+

PROTEIN_CLASS: 6.2.1.30

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YbiV

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( HyaA ) or ( HybC ) or ( HycB )

+

PROTEIN_CLASS: 1.18.99.1

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ArgT and HisM and HisP and HisQ ) or ( ArtI and ArtJ and ArtM and ArtP and ArtQ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IlvE

+

PROTEIN_CLASS: 2.6.1.42

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Dld ) or ( Ldh )

+

PROTEIN_CLASS: 1.1.1.28

+

SUBSYSTEM: S_Pyruvate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadI ) or ( FadA )

+

PROTEIN_CLASS: 2.3.1.16

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadI ) or ( FadA )

+

PROTEIN_CLASS: 2.3.1.16

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadA ) or ( FadI )

+

PROTEIN_CLASS: 2.3.1.16

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UbiE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadI ) or ( FadA )

+

PROTEIN_CLASS: 2.3.1.16

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadA ) or ( FadI )

+

PROTEIN_CLASS: 2.3.1.16

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SgaH ) or ( SgbH )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MtlA and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CdsA

+

PROTEIN_CLASS: 2.7.7.41

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadA ) or ( FadI )

+

PROTEIN_CLASS: 2.3.1.16

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadA ) or ( FadI )

+

PROTEIN_CLASS: 2.3.1.16

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadI ) or ( FadA )

+

PROTEIN_CLASS: 2.3.1.16

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Fre

+

PROTEIN_CLASS: 1.5.1.30

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PnuCec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CysG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TdcC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Lig ) or ( NudC )

+

PROTEIN_CLASS: 3.6.1.22

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PheP ) or ( AroP )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SolA

+

PROTEIN_CLASS: 1.5.3.1

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GltA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FumA ) or ( FumB ) or ( FumCec )

+

PROTEIN_CLASS: 4.2.1.2

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AllD

+

PROTEIN_CLASS: 1.1.1.154

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TyrS

+

PROTEIN_CLASS: 6.1.1.1

+

SUBSYSTEM: S_tRNA_charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GudD ) or ( YgcY )

+

PROTEIN_CLASS: 4.2.1.40

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mtn

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlgA

+

PROTEIN_CLASS: 2.4.1.21

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Cls ) or ( YbhO )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabF ) or ( FabB )

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: FabF

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AphA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DhaK and DhaL and DhaM and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Acc

+

PROTEIN_CLASS: 6.4.1.2

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ProB

+

PROTEIN_CLASS: 2.7.2.11

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YdfG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FucK

+

PROTEIN_CLASS: 2.7.1.51

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DeoC

+

PROTEIN_CLASS: 4.1.2.4

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NapAB and NapC )

+

PROTEIN_CLASS: 1.7.99.4

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RibFec

+

PROTEIN_CLASS: 2.7.1.26

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( SsuA and SsuB and SsuC ) or ( TauA and TauB and TauC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DsbA and DsbB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XylB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThiE

+

PROTEIN_CLASS: 2.5.1.3

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DsbA and DsbB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Gpt

+

PROTEIN_CLASS: 2.4.2.22

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HemH

+

PROTEIN_CLASS: 4.99.1.1

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PurB

+

PROTEIN_CLASS: 4.3.2.2

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Gsp

+

PROTEIN_CLASS: 6.3.1.8

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TauA and TauB and TauC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Amn

+

PROTEIN_CLASS: 3.2.2.4

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabB ) or ( FabF )

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabB

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: HisI

+

PROTEIN_CLASS: 3.6.1.31

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DapF

+

PROTEIN_CLASS: 5.1.1.7

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Nuo

+

PROTEIN_CLASS: 1.6.5.3

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PyrE

+

PROTEIN_CLASS: 2.4.2.10

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CrcA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ChaA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AphA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AtoADec

+

PROTEIN_CLASS: 2.8.3.8

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( ModA and ModB and ModC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: EptB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurB

+

PROTEIN_CLASS: 4.3.2.2

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ProPec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YfiK ) or ( EamA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FolB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MalP ) or ( GlgP )

+

PROTEIN_CLASS: 2.4.1.1

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: AraB

+

PROTEIN_CLASS: 2.7.1.16

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CsdA

+

PROTEIN_CLASS: 4.1.1.12

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Gsp

+

PROTEIN_CLASS: 3.5.1.78

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( UshA ) or ( AphA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UhpT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SpeA

+

PROTEIN_CLASS: 4.1.1.19

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabB ) or ( FabF )

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabB

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GatD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NhoA

+

PROTEIN_CLASS: 2.3.1.118

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: YffH

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Fmt

+

PROTEIN_CLASS: 2.1.2.9

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SurE

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SodA ) or ( SodB )

+

PROTEIN_CLASS: 1.15.1.1

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: WcaH

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SurE

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YfbR ) or ( SurE )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YrbG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpF ) or ( OmpN ) or ( OmpC ) or ( PhoE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpN ) or ( OmpC ) or ( PhoE ) or ( OmpF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GlyA ) or ( LtaE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CoaD

+

PROTEIN_CLASS: 2.7.7.3

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MhpB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlcDEF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LpxB

+

PROTEIN_CLASS: 2.4.1.182

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgD

+

PROTEIN_CLASS: 2.6.1.17

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( KdpA and KdpB and KdpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlcDEF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlcDEF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ManX and ManY and ManZ and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlmS

+

PROTEIN_CLASS: 2.6.1.16

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BioF

+

PROTEIN_CLASS: 2.3.1.47

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurL

+

PROTEIN_CLASS: 6.3.5.3

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HisA

+

PROTEIN_CLASS: 5.3.1.16

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AphA ) or ( UshA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArnA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MutT ) or ( MazG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MazG ) or ( MutT )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YgjG

+

PROTEIN_CLASS: 2.6.1.29

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AspS

+

PROTEIN_CLASS: 6.1.1.12

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AnsP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MenC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AcpH

+

PROTEIN_CLASS: 3.1.2.14

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MenE

+

PROTEIN_CLASS: 6.2.1.26

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PncB

+

PROTEIN_CLASS: 2.4.2.11

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AnsB

+

PROTEIN_CLASS: 3.5.1.2

+

SUBSYSTEM: S_Glutamate_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadD ) or ( FadK )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LysP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XylE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PuuP ) or ( PotEec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WecG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CodB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: KdsA

+

PROTEIN_CLASS: 4.1.2.16

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Crr and PtsG and PtsH and PtsI ) or ( NagE and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Slt ) or ( MltA ) or ( MltB ) or ( MltE ) or ( MltC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YrbI

+

PROTEIN_CLASS: 3.1.3.45

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NanK

+

PROTEIN_CLASS: 2.7.1.60

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DctA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MetI and MetN and MetQ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FieF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CaiB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mae

+

PROTEIN_CLASS: 1.1.1.40

+

SUBSYSTEM: S_Anaplerotic__Reactions

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YgfG

+

PROTEIN_CLASS: 4.1.1.41

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: EptB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Sfc

+

PROTEIN_CLASS: 1.1.1.38

+

SUBSYSTEM: S_Anaplerotic__Reactions

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IlvD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IlvD

+

PROTEIN_CLASS: 4.2.1.9

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CysIJ ) or ( Fre )

+

PROTEIN_CLASS: 1.5.1.30

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HemDec

+

PROTEIN_CLASS: 4.2.1.75

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NadEec

+

PROTEIN_CLASS: 6.3.1.5

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlgX

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mdh

+

PROTEIN_CLASS: 1.1.1.37

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CoaE

+

PROTEIN_CLASS: 2.7.1.24

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WecE

+

PROTEIN_CLASS: 2.6.1.33

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LivF and LivG and LivH and LivJ and LivM )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DcuA ) or ( DcuB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CysS

+

PROTEIN_CLASS: 6.1.1.16

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NhaB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GppA

+

PROTEIN_CLASS: 3.6.1.40

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NupG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: DgkA

+

PROTEIN_CLASS: 2.7.1.107

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgkA

+

PROTEIN_CLASS: 2.7.1.107

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Gpt ) or ( Hpt )

+

PROTEIN_CLASS: 2.4.2.8

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NagB

+

PROTEIN_CLASS: 3.5.99.6

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurH

+

PROTEIN_CLASS: 3.5.4.10

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GuaB

+

PROTEIN_CLASS: 1.1.1.205

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AgaZ ) or ( GatZ )

+

PROTEIN_CLASS: 4.1.2.40

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YjeQ

+

PROTEIN_CLASS: 3.6.1.15

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( HscC ) or ( YjeQ )

+

PROTEIN_CLASS: 3.6.1.15

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YjeQ

+

PROTEIN_CLASS: 3.6.1.15

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MenD

+

PROTEIN_CLASS: 4.1.1.71

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThrC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: FadL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LpxC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Udp

+

PROTEIN_CLASS: 2.4.2.2

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HisB

+

PROTEIN_CLASS: 4.2.1.19

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MazG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YfaO ) or ( MazG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: RdgB

+

PROTEIN_CLASS: 3.6.1.19

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MazG ) or ( NudG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BglX

+

PROTEIN_CLASS: 3.2.1.108

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MazG ) or ( YfaO ) or ( NudG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MazG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MazG ) or ( NtpA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BrnQ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BioAec

+

PROTEIN_CLASS: 2.6.1.62

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: LamB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AmpD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LamB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: EntS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FhuB and FhuC and FhuD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AppA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Crr and MurP and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Dfp

+

PROTEIN_CLASS: 6.3.2.5

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Fiu and Ton ) or ( CirA and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PyrC

+

PROTEIN_CLASS: 3.5.2.3

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpF ) or ( OmpN ) or ( OmpC ) or ( PhoE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsC

+

PROTEIN_CLASS: 2.3.1.51

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsC

+

PROTEIN_CLASS: 2.3.1.51

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PepB ) or ( PepA ) or ( PepD ) or ( PepN )

+

PROTEIN_CLASS: 3.4.11.2

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SetB ) or ( SetA ) or ( SotB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LdcC ) or ( CadA )

+

PROTEIN_CLASS: 4.1.1.18

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Pnt

+

PROTEIN_CLASS: 1.6.1.1

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XapB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CycAec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AraB ) or ( LyxK )

+

PROTEIN_CLASS: 2.7.1.53

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IdnD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mak

+

PROTEIN_CLASS: 2.7.1.1

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GalP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CbdAB ) or ( CydA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Glk

+

PROTEIN_CLASS: 2.7.1.1

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Cls ) or ( YbhO )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UhpT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 2.7.1.7

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LacZ

+

PROTEIN_CLASS: 3.2.1.23

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HcaCDEF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PfkA

+

PROTEIN_CLASS: 2.7.1.11

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IdnT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LytB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AcpH

+

PROTEIN_CLASS: 3.1.2.14

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YdcS and YdcT and YdcU and YdcV ) or ( PotF and PotG and PotH and PotI ) or ( PotA and PotB and PotC and PotDec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( BtuC and BtuD and BtuF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( CcmA and CcmB and CcmC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsC

+

PROTEIN_CLASS: 2.3.1.51

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsC

+

PROTEIN_CLASS: 2.3.1.51

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( NupG ) or ( NupCec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( HemX ) or ( CysG )

+

PROTEIN_CLASS: 2.1.1.107

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XylA

+

PROTEIN_CLASS: 5.3.1.5

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XylA

+

PROTEIN_CLASS: 5.3.1.5

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( XylB ) or ( AraB )

+

PROTEIN_CLASS: 2.7.1.17

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( NarZYWV ) or ( NarGHIJ )

+

PROTEIN_CLASS: 1.7.99.4

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LacY

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DeoA

+

PROTEIN_CLASS: 2.4.2.4

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Ggt

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZntA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CpdB

+

PROTEIN_CLASS: 3.1.4.16

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( RfbB ) or ( RffG )

+

PROTEIN_CLASS: 4.2.1.46

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Dxr

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( TdcB ) or ( SdaAec ) or ( SdaB ) or ( IlvA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FldA and Fpr and NrdD and NrdG ) or ( FldB and NrdD ) or ( FldA and NrdD ) or ( FldB and Fpr and NrdD and NrdG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NtpA ) or ( MutT )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YiaE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ValS

+

PROTEIN_CLASS: 6.1.1.9

+

SUBSYSTEM: S_tRNA_charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YiaE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ActP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DacB ) or ( MepA ) or ( PbpG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 5.1.99.1

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( IlvE ) or ( TyrB )

+

PROTEIN_CLASS: 2.6.1.42

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DcuB ) or ( DcuA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ProVec and ProW and ProX )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MurB

+

PROTEIN_CLASS: 1.1.1.158

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FldB and NrdD ) or ( FldA and Fpr and NrdD and NrdG ) or ( FldA and NrdD ) or ( FldB and Fpr and NrdD and NrdG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AceA

+

PROTEIN_CLASS: 4.1.3.1

+

SUBSYSTEM: S_Anaplerotic__Reactions

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Fre

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MngA and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AroC

+

PROTEIN_CLASS: 4.2.3.5

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FepB and FepC and FepD and FepG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CobT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MglA and MglB and MglC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PheA ) or ( TyrAec )

+

PROTEIN_CLASS: 5.4.99.5

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: WbbI

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mqo

+

PROTEIN_CLASS: 1.1.99.16

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MgtA ) or ( NikA and NikB and NikC and NikD and NikE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mqo

+

PROTEIN_CLASS: 1.1.99.16

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HcaT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SurE

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LamB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YfbR ) or ( SurE ) or ( YjjG )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThiDec

+

PROTEIN_CLASS: 2.7.4.7

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FldA and NrdD ) or ( FldB and NrdD ) or ( FldB and Fpr and NrdD and NrdG ) or ( FldA and Fpr and NrdD and NrdG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YfbR ) or ( SurE )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Udk

+

PROTEIN_CLASS: 2.7.1.48

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SurE

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZupT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NupG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YfbR ) or ( SurE )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YfbR ) or ( SurE ) or ( YjjG )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YjjG ) or ( SurE )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( SurE ) or ( YfbR )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AphA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SurE

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LpxK

+

PROTEIN_CLASS: 2.7.1.130

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThyA

+

PROTEIN_CLASS: 2.1.1.45

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tdk

+

PROTEIN_CLASS: 2.7.1.21

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( Lnt and Lpp )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DacA ) or ( DacB ) or ( DacC ) or ( DacD )

+

PROTEIN_CLASS: 3.4.16.4

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PutAec

+

PROTEIN_CLASS: 1.5.99.8

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UhpT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FldB and Fpr and NrdD and NrdG ) or ( FldB and NrdD ) or ( FldA and NrdD ) or ( FldA and Fpr and NrdD and NrdG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PdxK

+

PROTEIN_CLASS: 2.7.1.35

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AmpD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BetB

+

PROTEIN_CLASS: 1.2.1.8

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BetB

+

PROTEIN_CLASS: 1.2.1.8

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ApaH

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NagZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( KdgT ) or ( ExuT )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FhuB and FhuC and FhuD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AnmK

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadB

+

PROTEIN_CLASS: 5.3.3.8

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RbsK

+

PROTEIN_CLASS: 2.7.1.15

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BioD

+

PROTEIN_CLASS: 6.3.3.3

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SotB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NupG ) or ( NupCec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AcnB ) or ( AcnA )

+

PROTEIN_CLASS: 4.2.1.3

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AcnB ) or ( AcnA )

+

PROTEIN_CLASS: 4.2.1.3

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( SthA ) or ( Pnt )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TtdAB

+

PROTEIN_CLASS: 4.2.1.32

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TrxA and TrxB ) or ( TrxB and TrxC )

+

PROTEIN_CLASS: 1.8.1.9

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CueO

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( IscS and ThiFec and ThiGH and ThiI and ThiS )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TreF

+

PROTEIN_CLASS: 3.2.1.28

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( SsuA and SsuB and SsuC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NarKec ) or ( NirC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tdk

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: AvtA

+

PROTEIN_CLASS: 2.6.1.66

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: YaaJ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PotEec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpN ) or ( OmpF ) or ( OmpC ) or ( PhoE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpF ) or ( OmpN ) or ( OmpC ) or ( PhoE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YicE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UshA

+

PROTEIN_CLASS: 3.6.1.45

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GltI and GltJ and GltK and GltL )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( BtuB and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadD ) or ( FadK )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GltI and GltJ and GltK and GltL )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SerC

+

PROTEIN_CLASS: 2.6.1.52

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WbbK

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( BtuC and BtuD and BtuF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( AroP ) or ( Mtr ) or ( TnaB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AcnB

+

PROTEIN_CLASS: 4.2.1.99

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Gcl

+

PROTEIN_CLASS: 4.1.1.47

+

SUBSYSTEM: S_Glyoxylate_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FhuA and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Methylglyoxal_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: DsdA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( TdcG ) or ( SdaAec ) or ( SdaB ) or ( TnaA )

+

PROTEIN_CLASS: 4.3.1.17

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UshA ) or ( AphA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CaiC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( IlvB ) or ( IlvH )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: EntC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AmpG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TrpDec

+

PROTEIN_CLASS: 2.4.2.18

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FrmA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PurUec

+

PROTEIN_CLASS: 3.5.1.10

+

SUBSYSTEM: S_Folate_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GlgP ) or ( MalP )

+

PROTEIN_CLASS: 2.4.1.1

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgsA

+

PROTEIN_CLASS: 2.7.8.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NhaA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgsA

+

PROTEIN_CLASS: 2.7.8.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PhoA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AphA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IspF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.1.3.10

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Cls ) or ( YbhO )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZupT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CysH and GrxA ) or ( CysH and GrxB ) or ( CysH and GrxD ) or ( CysH and GrxC )

+

PROTEIN_CLASS: 1.8.4.8

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Gpt ) or ( Hpt )

+

PROTEIN_CLASS: 2.4.2.8

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpB ) or ( PgpA )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Edd

+

PROTEIN_CLASS: 4.2.1.12

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Eda

+

PROTEIN_CLASS: 4.1.2.14

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PepN ) or ( PepD ) or ( PepA ) or ( PepB )

+

PROTEIN_CLASS: 3.4.11.2

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CysG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadB

+

PROTEIN_CLASS: 5.3.3.8

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurC

+

PROTEIN_CLASS: 6.3.2.6

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AroD

+

PROTEIN_CLASS: 4.2.1.10

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Agp

+

PROTEIN_CLASS: 3.1.3.10

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Fes

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgsA

+

PROTEIN_CLASS: 2.7.8.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FeoB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IspB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GlyA ) or ( LtaE )

+

PROTEIN_CLASS: 4.1.2.5

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Asd

+

PROTEIN_CLASS: 1.2.1.11

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( DacA ) or ( DacB ) or ( DacC ) or ( DacD )

+

PROTEIN_CLASS: 3.4.16.4

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZupT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Maa

+

PROTEIN_CLASS: 2.3.1.79

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UgpA and UgpB and UgpC and UgpE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UbiG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Gmd

+

PROTEIN_CLASS: 4.2.1.47

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PhpB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PyrD

+

PROTEIN_CLASS: 1.3.3.1

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IleS

+

PROTEIN_CLASS: 6.1.1.5

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgsA

+

PROTEIN_CLASS: 2.7.8.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HemF

+

PROTEIN_CLASS: 1.3.3.3

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FecB and FecC and FecD and FecE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LtaE ) or ( GlyA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DdlA ) or ( DdlB )

+

PROTEIN_CLASS: 6.3.2.4

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ProVec and ProW and ProX )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PyrD

+

PROTEIN_CLASS: 1.3.3.1

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgkA

+

PROTEIN_CLASS: 2.7.1.107

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Fdn ) or ( Fdoec )

+

PROTEIN_CLASS: 1.2.2.1

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GntP ) or ( GntU ) or ( GntT ) or ( IdnT )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgsA

+

PROTEIN_CLASS: 2.7.8.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgkA

+

PROTEIN_CLASS: 2.7.1.107

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpN ) or ( OmpC ) or ( OmpF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AphA ) or ( UshA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Fre

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: XapB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DdpX

+

PROTEIN_CLASS: 3.4.17.14

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Upp

+

PROTEIN_CLASS: 2.4.2.9

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThiL

+

PROTEIN_CLASS: 2.7.4.16

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpC ) or ( OmpN ) or ( PhoE ) or ( OmpF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MenB

+

PROTEIN_CLASS: 4.1.3.36

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Dgt

+

PROTEIN_CLASS: 3.1.5.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Dgt

+

PROTEIN_CLASS: 3.1.5.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgkA

+

PROTEIN_CLASS: 2.7.1.107

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GatA and GatB and GatC and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgsA

+

PROTEIN_CLASS: 2.7.8.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurK

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BglA

+

PROTEIN_CLASS: 3.2.1.86

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgsA

+

PROTEIN_CLASS: 2.7.8.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SdaC ) or ( TdcC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgkA

+

PROTEIN_CLASS: 2.7.1.107

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AraF and AraG and AraH )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgkA

+

PROTEIN_CLASS: 2.7.1.107

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AcpS ) or ( AcpT )

+

PROTEIN_CLASS: 2.7.8.7

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XapB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgH

+

PROTEIN_CLASS: 4.3.2.1

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( DeoA ) or ( DeoD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgG

+

PROTEIN_CLASS: 6.3.4.5

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: RfaEec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( MetL ) or ( ThrA )

+

PROTEIN_CLASS: 1.1.1.3

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DsbD and DsbG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DsbC and DsbD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LeuS

+

PROTEIN_CLASS: 6.1.1.4

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YbiV

+

PROTEIN_CLASS: 3.1.3.9

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgoK

+

PROTEIN_CLASS: 2.7.1.58

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NorV and NorW )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UshA

+

PROTEIN_CLASS: 3.6.1.45

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FecA and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Acs

+

PROTEIN_CLASS: 6.2.1.1

+

SUBSYSTEM: S_Pyruvate_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: DapA

+

PROTEIN_CLASS: 4.2.1.52

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( OppA and OppB and OppC and OppD and OppF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ThiDec ) or ( PdxK )

+

PROTEIN_CLASS: 2.7.1.49

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: YicP

+

PROTEIN_CLASS: 3.5.4.2

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Add

+

PROTEIN_CLASS: 3.5.4.4

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Sbm

+

PROTEIN_CLASS: 5.4.99.2

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ActP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GshB

+

PROTEIN_CLASS: 6.3.2.3

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AdiC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YehW and YehX and YehY and YehZ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Epd

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FhuB and FhuC and FhuD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SsuD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LpdA and SucAec and SucBec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpF ) or ( OmpN ) or ( OmpC ) or ( PhoE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Aas

+

PROTEIN_CLASS: 2.3.1.40

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Hyi

+

PROTEIN_CLASS: 5.3.1.22

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( HisJ and HisM and HisP and HisQ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YjfF and YtfQ and YtfR and YtfT ) or ( RbsA and RbsB and RbsC and RbsDec ) or ( AlsA and AlsB and AlsC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Eno

+

PROTEIN_CLASS: 4.2.1.11

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PdxB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( WzyE and WzzE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( ArcCec ) or ( YahI ) or ( YqeA )

+

PROTEIN_CLASS: 2.7.2.2

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AtoADec

+

PROTEIN_CLASS: 2.8.3.8

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MhpA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YliI ) or ( Gcd )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MgtA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpC ) or ( PhoE ) or ( OmpF ) or ( OmpN )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YgfP

+

PROTEIN_CLASS: 3.5.4.3

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AmpD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: HisI

+

PROTEIN_CLASS: 3.5.4.19

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YdcW

+

PROTEIN_CLASS: 1.2.1.19

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Fes

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpC ) or ( PhoE ) or ( OmpF ) or ( OmpN )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UshA

+

PROTEIN_CLASS: 3.6.1.45

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AllC

+

PROTEIN_CLASS: 3.5.3.9

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Dxs

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgO

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DcuA ) or ( DcuB ) or ( DcuC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Nuo

+

PROTEIN_CLASS: 1.6.5.3

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ThrA ) or ( MetL ) or ( LysCec )

+

PROTEIN_CLASS: 2.7.2.4

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SpeG

+

PROTEIN_CLASS: 2.3.1.57

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CueO

+

PROTEIN_CLASS: 1.16.3.1

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SpeG

+

PROTEIN_CLASS: 2.3.1.57

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( RffH ) or ( RfbA )

+

PROTEIN_CLASS: 2.7.7.24

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YiaK

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Ppsa

+

PROTEIN_CLASS: 2.7.9.2

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AnsB

+

PROTEIN_CLASS: 3.5.1.1

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: FadL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DeoB ) or ( YhfW )

+

PROTEIN_CLASS: 5.4.2.7

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalQ

+

PROTEIN_CLASS: 2.4.1.25

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Crr and PtsG and PtsH and PtsI ) or ( ManX and ManY and ManZ and PtsH and PtsI ) or ( Crr and MalX and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalQ

+

PROTEIN_CLASS: 2.4.1.25

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalQ

+

PROTEIN_CLASS: 2.4.1.25

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalQ

+

PROTEIN_CLASS: 2.4.1.25

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DctA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpN ) or ( OmpC ) or ( OmpF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PoxB

+

PROTEIN_CLASS: 1.2.2.2

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CysKec ) or ( CysM )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TnaA

+

PROTEIN_CLASS: 4.1.99.1

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( UshA ) or ( AphA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cdd

+

PROTEIN_CLASS: 3.5.4.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SPONTANEOUS ) or ( GlpF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AnsA ) or ( YbiK )

+

PROTEIN_CLASS: 3.5.1.1

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Ppc

+

PROTEIN_CLASS: 4.1.1.31

+

SUBSYSTEM: S_Anaplerotic__Reactions

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Ppa ) or ( Ppx ) or ( SurE )

+

PROTEIN_CLASS: 3.6.1.1

+

SUBSYSTEM: S_Anaplerotic__Reactions

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GlnA ) or ( YcjK )

+

PROTEIN_CLASS: 6.3.1.2

+

SUBSYSTEM: S_Glutamate_metabolism

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ArgT and HisM and HisP and HisQ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ArgT and HisM and HisP and HisQ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DgoA

+

PROTEIN_CLASS: 4.1.2.21

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( RhtA ) or ( RhtB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SuhB

+

PROTEIN_CLASS: 3.1.3.25

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RelA

+

PROTEIN_CLASS: 2.7.6.5

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: AdiA

+

PROTEIN_CLASS: 4.1.1.19

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FepA and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NarZYWV ) or ( NarGHIJ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AceB ) or ( GlcB )

+

PROTEIN_CLASS: 4.1.3.2

+

SUBSYSTEM: S_Anaplerotic__Reactions

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YbjG ) or ( PgpB ) or ( UppP )

+

PROTEIN_CLASS: 3.6.1.27

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MetH ) or ( MetE )

+

PROTEIN_CLASS: 2.1.1.13

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YfiK ) or ( EamA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Icd

+

PROTEIN_CLASS: 1.1.1.42

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CpdB

+

PROTEIN_CLASS: 3.1.4.16

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadD ) or ( FadK )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ZitB ) or ( FieF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YehW and YehX and YehY and YehZ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AspA

+

PROTEIN_CLASS: 4.3.1.1

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YfaO ) or ( Dutec )

+

PROTEIN_CLASS: 3.6.1.23

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PrpD

+

PROTEIN_CLASS: 4.2.1.79

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Cls ) or ( YbhO )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YiaE ) or ( YcdW )

+

PROTEIN_CLASS: 1.1.1.26

+

SUBSYSTEM: S_Glyoxylate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YiaE ) or ( YcdW )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glyoxylate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FtsI ) or ( MrdA ) or ( MrcA ) or ( MrcB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DctA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 2.6.1.2

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AstC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PanB

+

PROTEIN_CLASS: 2.1.2.11

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SolA

+

PROTEIN_CLASS: 1.5.3.2

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FeaB

+

PROTEIN_CLASS: 1.2.1.39

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CaiC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tsx

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MngB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LdcA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SsuD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: SsuD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SsuD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UgpA and UgpB and UgpC and UgpE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AsnA

+

PROTEIN_CLASS: 6.3.1.1

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BtuR

+

PROTEIN_CLASS: 2.5.1.17

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AsnB

+

PROTEIN_CLASS: 6.3.5.4

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MetK

+

PROTEIN_CLASS: 2.5.1.6

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SsuD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabG

+

PROTEIN_CLASS: 1.1.1.100

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AstE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FrmB ) or ( YeiG )

+

PROTEIN_CLASS: 3.1.2.12

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: FabB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DcuB ) or ( DcuA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlgC

+

PROTEIN_CLASS: 2.7.7.27

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ApaH

+

PROTEIN_CLASS: 3.6.1.41

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XapB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YiaE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YiaE

+

PROTEIN_CLASS: 1.1.1.215

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SerS

+

PROTEIN_CLASS: 6.1.1.11

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TalA ) or ( TalB )

+

PROTEIN_CLASS: 2.2.1.2

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ManC

+

PROTEIN_CLASS: 2.7.7.22

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Rfc and WzzB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: KdgT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CysIJ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: KgtPec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpB ) or ( PgpA )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YiaE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CpdB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YiaE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MetA

+

PROTEIN_CLASS: 2.3.1.46

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TdcD

+

PROTEIN_CLASS: 2.7.2.1

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ProPec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GntP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: GlpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PrpC

+

PROTEIN_CLASS: 4.1.3.31

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurH

+

PROTEIN_CLASS: 2.1.2.3

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BrnQ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PheA

+

PROTEIN_CLASS: 4.2.1.51

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FieF ) or ( ZitB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MrcB ) or ( PbpC ) or ( MrcA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( Pyka ) or ( Pykf )

+

PROTEIN_CLASS: 2.7.1.40

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HisF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MrcB ) or ( MrcA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( NupG ) or ( NupCec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YjfR

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cmk

+

PROTEIN_CLASS: 2.7.4.14

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TrpA

+

PROTEIN_CLASS: 4.2.1.20

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgO

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TrpA

+

PROTEIN_CLASS: 4.2.1.20

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TrpA

+

PROTEIN_CLASS: 4.2.1.20

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: AtoADec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TynA

+

PROTEIN_CLASS: 1.4.3.6

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cmk

+

PROTEIN_CLASS: 2.7.4.14

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CoaA

+

PROTEIN_CLASS: 2.7.1.33

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MraY

+

PROTEIN_CLASS: 2.7.8.13

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: WaaC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaU

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaQ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Gmkec

+

PROTEIN_CLASS: 2.7.4.8

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsB

+

PROTEIN_CLASS: 2.3.1.15

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PutAec

+

PROTEIN_CLASS: 1.5.1.12

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PheTS

+

PROTEIN_CLASS: 6.1.1.20

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MurC

+

PROTEIN_CLASS: 6.3.2.8

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: RihC

+

PROTEIN_CLASS: 3.2.2.8

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NupG ) or ( NupCec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ProC

+

PROTEIN_CLASS: 1.5.1.2

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TynA

+

PROTEIN_CLASS: 1.4.3.6

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Fcl

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LysU ) or ( LysS )

+

PROTEIN_CLASS: 6.1.1.6

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Slt ) or ( MltA ) or ( MltB ) or ( MltE ) or ( MltC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PtsH and PtsI and SrlA and SrlB and SrlE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: AtoE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FolXec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( ArgI ) or ( ArgF )

+

PROTEIN_CLASS: 2.1.3.3

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: DsbG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IspD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThiMec

+

PROTEIN_CLASS: 2.7.1.50

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArnA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DacB ) or ( MepA ) or ( PbpG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YgiN

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YgiN

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MetF

+

PROTEIN_CLASS: 1.5.1.20

+

SUBSYSTEM: S_Folate_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: GlmUec

+

PROTEIN_CLASS: 2.3.1.157

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YnfEFGH ) or ( DmsABC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PanCec

+

PROTEIN_CLASS: 6.3.2.1

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DmsABC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AmiC ) or ( AmiB ) or ( AmiA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CaiT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SstT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SpeC ) or ( SpeF )

+

PROTEIN_CLASS: 4.1.1.17

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CynT ) or ( YadF )

+

PROTEIN_CLASS: 4.2.1.1

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CpdB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SfuA and SfuB and SfuC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Aas and AcpP )

+

PROTEIN_CLASS: 6.2.1.20

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UbiD ) or ( UbiX )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YnfEFGH ) or ( DmsABC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AcpH

+

PROTEIN_CLASS: 3.1.2.14

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpC ) or ( OmpN ) or ( PhoE ) or ( OmpF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadK ) or ( FadD )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tsx

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AlsE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DmsABC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 1.1.1.35

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GalE

+

PROTEIN_CLASS: 5.1.3.2

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AldH

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GalP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LamB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Cls ) or ( YbhO )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadE

+

PROTEIN_CLASS: 1.3.99.3

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MurFec

+

PROTEIN_CLASS: 6.3.2.15

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Aas and AcpP )

+

PROTEIN_CLASS: 6.2.1.20

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HcaCDEF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Aas and AcpP )

+

PROTEIN_CLASS: 6.2.1.20

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PssA

+

PROTEIN_CLASS: 2.7.8.8

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Aas and AcpP )

+

PROTEIN_CLASS: 6.2.1.20

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PssA

+

PROTEIN_CLASS: 2.7.8.8

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Aas and AcpP )

+

PROTEIN_CLASS: 6.2.1.20

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Aas and AcpP )

+

PROTEIN_CLASS: 6.2.1.20

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Aas and AcpP )

+

PROTEIN_CLASS: 6.2.1.20

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Aas and AcpP )

+

PROTEIN_CLASS: 6.2.1.20

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Aas and AcpP )

+

PROTEIN_CLASS: 6.2.1.20

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 1.1.1.35

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AstD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadD ) or ( FadK )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FocA ) or ( FocB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MppA and OppB and OppC and OppD and OppF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FhuB and FhuC and FhuD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpN ) or ( OmpC ) or ( PhoE ) or ( OmpF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AmyA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TreA

+

PROTEIN_CLASS: 3.2.1.28

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PssA

+

PROTEIN_CLASS: 2.7.8.8

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PssA

+

PROTEIN_CLASS: 2.7.8.8

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 1.1.1.35

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LamB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RihC

+

PROTEIN_CLASS: 3.2.2.8

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: LeuC

+

PROTEIN_CLASS: 4.2.1.33

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PuuD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LeuC

+

PROTEIN_CLASS: 4.2.1.33

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadE

+

PROTEIN_CLASS: 1.3.99.3

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PrsA

+

PROTEIN_CLASS: 2.7.6.1

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsC

+

PROTEIN_CLASS: 2.3.1.51

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AllP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FolK

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpC ) or ( OmpN ) or ( OmpF ) or ( PhoE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CadB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YidK

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BrnQ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: HcaB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GlxR ) or ( GarR )

+

PROTEIN_CLASS: 1.1.1.60

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadE

+

PROTEIN_CLASS: 1.3.99.3

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DacA ) or ( DacB ) or ( DacC ) or ( DacD )

+

PROTEIN_CLASS: 3.4.16.4

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WecC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PssA

+

PROTEIN_CLASS: 2.7.8.8

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UbiC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( RhtA ) or ( RhtC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RibA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AphA ) or ( UshA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LysA

+

PROTEIN_CLASS: 4.1.1.20

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaY

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( RihB ) or ( RihA ) or ( RihC )

+

PROTEIN_CLASS: 3.2.2.8

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DsbC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.2.2.14

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsC

+

PROTEIN_CLASS: 2.3.1.51

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CobU

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadE

+

PROTEIN_CLASS: 1.3.99.3

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsC

+

PROTEIN_CLASS: 2.3.1.51

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YbiV

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.4.17.13

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: EntA

+

PROTEIN_CLASS: 1.3.1.28

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CyoE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SrlD

+

PROTEIN_CLASS: 1.1.1.140

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ArgD ) or ( AstC )

+

PROTEIN_CLASS: 2.6.1.11

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: FolP

+

PROTEIN_CLASS: 2.5.1.15

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: EntE

+

PROTEIN_CLASS: 2.7.7.58

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FrlB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CysD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadE

+

PROTEIN_CLASS: 1.3.99.3

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PssA

+

PROTEIN_CLASS: 2.7.8.8

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NanC ) or ( OmpF ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PssA

+

PROTEIN_CLASS: 2.7.8.8

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.2.2.10

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GloA

+

PROTEIN_CLASS: 4.4.1.5

+

SUBSYSTEM: S_Methylglyoxal_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cfa

+

PROTEIN_CLASS: 2.1.1.79

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cfa

+

PROTEIN_CLASS: 2.1.1.79

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CopA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.2.2.14

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MalE and MalF and MalG and MalK )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadE

+

PROTEIN_CLASS: 1.3.99.2

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YgeX

+

PROTEIN_CLASS: 4.3.1.15

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UxaC

+

PROTEIN_CLASS: 5.3.1.12

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Bcp and TrxC ) or ( Bcp and TrxA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgS

+

PROTEIN_CLASS: 6.1.1.19

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UxaC

+

PROTEIN_CLASS: 5.3.1.12

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FrmA ) or ( AdhP ) or ( AdhE )

+

PROTEIN_CLASS: 1.1.1.1

+

SUBSYSTEM: S_Pyruvate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FepB and FepC and FepD and FepG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZupT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Cmk ) or ( PyrHec )

+

PROTEIN_CLASS: 2.7.4.14

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Gsk

+

PROTEIN_CLASS: 2.7.1.73

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Frd

+

PROTEIN_CLASS: 1.3.99.1

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PabBec ) or ( YbaS ) or ( YneH )

+

PROTEIN_CLASS: 3.5.1.2

+

SUBSYSTEM: S_Glutamate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LuxS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MurI

+

PROTEIN_CLASS: 5.1.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FrmA

+

PROTEIN_CLASS: 1.1.1.1

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: FadE

+

PROTEIN_CLASS: 1.3.99.3

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RihC

+

PROTEIN_CLASS: 3.2.2.8

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Frd

+

PROTEIN_CLASS: 1.3.99.1

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CaiC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NirBD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LivF and LivG and LivH and LivJ and LivM )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UppS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadB

+

PROTEIN_CLASS: 5.3.3.8

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XapB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PyrHec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GabT ) or ( PuuE )

+

PROTEIN_CLASS: 2.6.1.19

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RibDec

+

PROTEIN_CLASS: 3.5.4.26

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Maa

+

PROTEIN_CLASS: 2.3.1.79

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PflBec and YfiD ) or ( PflBec ) or ( TdcEec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FadE

+

PROTEIN_CLASS: 1.3.99.3

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Adk

+

PROTEIN_CLASS: 2.7.1.20

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UshA ) or ( AphA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GrxB and NrdE ) or ( GrxC and NrdE ) or ( GrxD and NrdE ) or ( GrxA and NrdE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ManA

+

PROTEIN_CLASS: 5.3.1.8

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LeuB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Glf

+

PROTEIN_CLASS: 5.4.99.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MpaA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CaiB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PanE ) or ( IlvCec )

+

PROTEIN_CLASS: 1.1.1.169

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: XdhABC

+

PROTEIN_CLASS: 1.1.1.204

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FrlA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: EntD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlyA

+

PROTEIN_CLASS: 2.1.2.1

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ProPec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mtr

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PutPec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AcpH

+

PROTEIN_CLASS: 3.1.2.14

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GrxD and NrdE ) or ( GrxB and NrdE ) or ( GrxA and NrdE ) or ( GrxC and NrdE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NupG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThrB

+

PROTEIN_CLASS: 2.7.1.39

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MmuP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UxuAec

+

PROTEIN_CLASS: 4.2.1.8

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( UgpA and UgpB and UgpC and UgpE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GrxC and NrdE ) or ( GrxB and NrdE ) or ( GrxD and NrdE ) or ( GrxA and NrdE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YdfG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Crr and MalX and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NagA

+

PROTEIN_CLASS: 3.5.1.25

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ApaH

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Ppk

+

PROTEIN_CLASS: 2.7.4.1

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UraA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpE

+

PROTEIN_CLASS: 2.8.1.1

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArnB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpB ) or ( PgpA )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GrxD and NrdE ) or ( GrxA and NrdE ) or ( GrxB and NrdE ) or ( GrxC and NrdE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IdnT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HemE

+

PROTEIN_CLASS: 4.1.1.37

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Agp

+

PROTEIN_CLASS: 3.1.3.10

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GldA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TorYZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpK

+

PROTEIN_CLASS: 2.7.1.30

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: UbiF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CorA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FhuA and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XasA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HisS

+

PROTEIN_CLASS: 6.1.1.21

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: EntF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YcjG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UbiB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SodC

+

PROTEIN_CLASS: 1.15.1.1

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: KdsBec

+

PROTEIN_CLASS: 2.7.7.38

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NrdA and TrxC ) or ( NrdA and TrxA )

+

PROTEIN_CLASS: 1.17.4.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NrdA and TrxA ) or ( NrdA and TrxC )

+

PROTEIN_CLASS: 1.17.4.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( NrdA and TrxC ) or ( NrdA and TrxA )

+

PROTEIN_CLASS: 1.17.4.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NrdA and TrxC ) or ( NrdA and TrxA )

+

PROTEIN_CLASS: 1.17.4.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DacB ) or ( MepA ) or ( PbpG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MurEec

+

PROTEIN_CLASS: 6.3.2.13

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabZ ) or ( FabA )

+

PROTEIN_CLASS: 4.2.1.61

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabA ) or ( FabZ )

+

PROTEIN_CLASS: 4.2.1.61

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( ZupT ) or ( CorA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.2.2.5

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DctA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FieF ) or ( ZitB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YfjB

+

PROTEIN_CLASS: 2.7.1.23

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CorA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CpsG

+

PROTEIN_CLASS: 5.4.2.8

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LdcA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FrlC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( MalY ) or ( MetC )

+

PROTEIN_CLASS: 4.4.1.8

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HcaB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MhpB

+

PROTEIN_CLASS: 1.13.11.16

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AcpP and FabD )

+

PROTEIN_CLASS: 2.3.1.39

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HemG

+

PROTEIN_CLASS: 1.3.3.4

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( Alrec ) or ( DadX )

+

PROTEIN_CLASS: 5.1.1.1

+

SUBSYSTEM: S_Alanine_and_Aspartate_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WecF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SsuA and SsuB and SsuC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AroB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IdnO

+

PROTEIN_CLASS: 1.1.1.69

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabA ) or ( FabZ )

+

PROTEIN_CLASS: 4.2.1.60

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AphA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FrlA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZupT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PyrF

+

PROTEIN_CLASS: 4.1.1.23

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tsx

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TynA

+

PROTEIN_CLASS: 1.4.3.6

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LyxK

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CitDEF and CitX )

+

PROTEIN_CLASS: 4.1.3.6

+

SUBSYSTEM: S_Citric_Acid_Cycle

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MsrB and TrxC ) or ( MsrB and TrxA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( MsrA and TrxC ) or ( MsrA and TrxA )

+

PROTEIN_CLASS: 1.8.4.5

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FrlD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Pta ) or ( EutD )

+

PROTEIN_CLASS: 2.3.1.8

+

SUBSYSTEM: S_Pyruvate_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RhaD

+

PROTEIN_CLASS: 4.1.2.19

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AllA

+

PROTEIN_CLASS: 3.5.3.19

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabB ) or ( FabF )

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GuaC

+

PROTEIN_CLASS: 1.7.1.7

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: WaaZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LldD

+

PROTEIN_CLASS: 1.1.2.3

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LldD

+

PROTEIN_CLASS: 1.1.2.3

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SurE ) or ( Ppx )

+

PROTEIN_CLASS: 3.6.1.1

+

SUBSYSTEM: S_Anaplerotic__Reactions

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IspA

+

PROTEIN_CLASS: 2.5.1.1

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SpoT

+

PROTEIN_CLASS: 3.1.7.2

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CynS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CrcA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArcD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Cdh

+

PROTEIN_CLASS: 3.6.1.26

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cdh

+

PROTEIN_CLASS: 3.6.1.26

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PgpB

+

PROTEIN_CLASS: 3.1.3.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( AphA ) or ( UshA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FtsI ) or ( MrdA ) or ( MrcB ) or ( MrcA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DapB

+

PROTEIN_CLASS: 1.3.1.26

+

SUBSYSTEM: S_Threonine_and__Lysine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UgpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HisB

+

PROTEIN_CLASS: 3.1.3.15

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.5.1.42

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TyrP ) or ( AroP ) or ( PheP )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UgpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UgpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UgpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Lnt and Lpp )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CusCFBA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UgpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PurN

+

PROTEIN_CLASS: 2.1.2.2

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabB ) or ( FabF )

+

PROTEIN_CLASS: 2.3.1.41

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpN ) or ( OmpF ) or ( OmpC ) or ( PhoE ) or ( SPONTANEOUS ) or ( OmpL ) or ( OmpG ) or ( OmpA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( HyaA ) or ( HybC )

+

PROTEIN_CLASS: 1.18.99.1

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HisD

+

PROTEIN_CLASS: 1.1.1.23

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HisG

+

PROTEIN_CLASS: 2.4.2.17

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpN ) or ( OmpF ) or ( PhoE ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Sdh

+

PROTEIN_CLASS: 1.3.99.1

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( WzyE and WzzE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MetI and MetN and MetQ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AtpF0 and AtpF1 ) or ( AtpF0 and AtpF1 and AtpI )

+

PROTEIN_CLASS: 3.6.3.14

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PitBec ) or ( PitA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AtoE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HemN

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YicE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cdh

+

PROTEIN_CLASS: 3.6.1.26

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: YdfG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cdh

+

PROTEIN_CLASS: 3.6.1.26

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( Pgmec ) or ( YqaB )

+

PROTEIN_CLASS: 5.4.2.2

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Dld

+

PROTEIN_CLASS: 1.1.2.4

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LldP ) or ( GlcA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RfbC

+

PROTEIN_CLASS: 5.1.3.13

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CyaA

+

PROTEIN_CLASS: 4.6.1.1

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgE

+

PROTEIN_CLASS: 3.5.1.16

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: AldH

+

PROTEIN_CLASS: 1.2.1.3

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AldB

+

PROTEIN_CLASS: 1.2.1.4

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PncA

+

PROTEIN_CLASS: 3.5.1.19

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadK ) or ( FadD )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Zwf

+

PROTEIN_CLASS: 1.1.1.49

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RfbD

+

PROTEIN_CLASS: 1.1.1.133

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Slt ) or ( MltA ) or ( MltB ) or ( MltE ) or ( MltC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NadD ) or ( NadR )

+

PROTEIN_CLASS: 2.7.7.1

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mpl

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( RihB ) or ( RihA ) or ( RihC )

+

PROTEIN_CLASS: 3.2.2.8

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WecD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 1.7.3.3

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZntA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZntA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PdxK ) or ( PdxYec )

+

PROTEIN_CLASS: 2.7.1.35

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NadCec

+

PROTEIN_CLASS: 2.4.2.19

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( YdiB ) or ( AroEec )

+

PROTEIN_CLASS: 1.1.1.25

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgB

+

PROTEIN_CLASS: 2.7.2.8

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cdh

+

PROTEIN_CLASS: 3.6.1.26

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MntH

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ArgA

+

PROTEIN_CLASS: 2.3.1.1

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SerA

+

PROTEIN_CLASS: 1.1.1.95

+

SUBSYSTEM: S_Glycine_and__Serine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TorYZ ) or ( TorCA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpB ) or ( YbjG ) or ( UppP )

+

PROTEIN_CLASS: 3.6.1.27

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArgC

+

PROTEIN_CLASS: 1.2.1.38

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( XylF and XylG and XylH )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BtuR

+

PROTEIN_CLASS: 2.5.1.17

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( SsuE ) or ( Fre )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GutQ ) or ( YrbH )

+

PROTEIN_CLASS: 5.3.1.13

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AraE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 4.2.1.17

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 4.2.1.17

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NagZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 4.2.1.17

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 4.2.1.17

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 4.2.1.17

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadJ ) or ( FadB )

+

PROTEIN_CLASS: 4.2.1.17

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabZ ) or ( FabA )

+

PROTEIN_CLASS: 4.2.1.61

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MdfA ) or ( ChaA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabA ) or ( FabZ )

+

PROTEIN_CLASS: 4.2.1.61

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 4.2.1.17

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 4.2.1.17

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FolM ) or ( FolA )

+

PROTEIN_CLASS: 1.5.1.3

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GldA

+

PROTEIN_CLASS: 1.1.1.21

+

SUBSYSTEM: S_Methylglyoxal_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FolCec

+

PROTEIN_CLASS: 6.3.2.12

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cdh

+

PROTEIN_CLASS: 3.6.1.26

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpN ) or ( OmpF ) or ( OmpC ) or ( PhoE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SpeB

+

PROTEIN_CLASS: 3.5.3.11

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 1.1.1.35

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FhuA and Ton )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MglA and MglB and MglC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Rfc and WzzB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cdh

+

PROTEIN_CLASS: 3.6.1.26

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: FruK

+

PROTEIN_CLASS: 2.7.1.56

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ThiC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DacA ) or ( DacB ) or ( DacC ) or ( DacD )

+

PROTEIN_CLASS: 3.4.16.4

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: GlgB

+

PROTEIN_CLASS: 2.4.1.18

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Kch ) or ( SapD and TrkA and TrkG ) or ( Kup ) or ( SapD and TrkA and TrkH )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: BisC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( MalE and MalF and MalG and MalK )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AsnS

+

PROTEIN_CLASS: 6.1.1.22

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CyoA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: BisC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GlpQ

+

PROTEIN_CLASS: 3.1.4.46

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MntH

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ArnC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabZ ) or ( FabA )

+

PROTEIN_CLASS: 4.2.1.61

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UshA

+

PROTEIN_CLASS: 3.6.1.45

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabA ) or ( FabZ )

+

PROTEIN_CLASS: 4.2.1.61

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TauA and TauB and TauC ) or ( SsuA and SsuB and SsuC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadJ ) or ( FadB )

+

PROTEIN_CLASS: 1.1.1.35

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Crr and MurP and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YaaJ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UshA ) or ( AphA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Pta

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TdcD ) or ( AckA ) or ( PurT )

+

PROTEIN_CLASS: 2.7.2.1

+

SUBSYSTEM: S_Pyruvate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( IlvH ) or ( IlvB )

+

PROTEIN_CLASS: 4.1.3.18

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Ndk ) or ( Adk )

+

PROTEIN_CLASS: 2.7.4.6

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Ndk ) or ( Adk )

+

PROTEIN_CLASS: 2.7.4.6

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AmpG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Adk ) or ( Ndk )

+

PROTEIN_CLASS: 2.7.4.6

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GabD

+

PROTEIN_CLASS: 1.2.1.16

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Adk ) or ( Ndk )

+

PROTEIN_CLASS: 2.7.4.6

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 1.2.1.24

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Adk ) or ( Ndk )

+

PROTEIN_CLASS: 2.7.4.6

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HisC

+

PROTEIN_CLASS: 2.6.1.9

+

SUBSYSTEM: S_Histidine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CaiT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Ndk ) or ( Adk )

+

PROTEIN_CLASS: 2.7.4.6

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 1.1.1.35

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Adk ) or ( Ndk )

+

PROTEIN_CLASS: 2.7.4.6

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Ndk ) or ( Adk )

+

PROTEIN_CLASS: 2.7.4.6

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabA ) or ( FabZ )

+

PROTEIN_CLASS: 4.2.1.61

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DctA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FabA ) or ( FabZ )

+

PROTEIN_CLASS: 4.2.1.61

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NupCec ) or ( NupG )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ShiA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mtn

+

PROTEIN_CLASS: 3.2.2.9

+

SUBSYSTEM: S_Methionine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FhuB and FhuC and FhuD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AldA

+

PROTEIN_CLASS: 1.2.1.21

+

SUBSYSTEM: S_Folate_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MelB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YeaV

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PdxAJ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 1.1.1.35

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ProPec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SpeE

+

PROTEIN_CLASS: 2.5.1.16

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PyrG

+

PROTEIN_CLASS: 6.3.4.2

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ProVec and ProW and ProX )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NagK

+

PROTEIN_CLASS: 2.7.1.59

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FolD

+

PROTEIN_CLASS: 1.5.1.5

+

SUBSYSTEM: S_Folate_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FolD

+

PROTEIN_CLASS: 3.5.4.9

+

SUBSYSTEM: S_Folate_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SerC

+

PROTEIN_CLASS: 2.6.1.52

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CpdB

+

PROTEIN_CLASS: 3.1.4.16

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpA ) or ( PgpB )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Crr and PtsH and PtsI and TreB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GAPOR

+

PROTEIN_CLASS: 1.8.1.7

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WecA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadB ) or ( FadJ )

+

PROTEIN_CLASS: 1.1.1.35

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpC ) or ( OmpN )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TnaA ) or ( MetC )

+

PROTEIN_CLASS: 4.1.99.1

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AroP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GltP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: IspE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsB

+

PROTEIN_CLASS: 2.3.1.15

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Ppk

+

PROTEIN_CLASS: 2.7.4.1

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsB

+

PROTEIN_CLASS: 2.3.1.15

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AllB

+

PROTEIN_CLASS: 3.5.2.5

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( DkgA ) or ( DkgB ) or ( YeaE ) or ( YghZ )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Methylglyoxal_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DeoB

+

PROTEIN_CLASS: 5.4.2.7

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TrpCec

+

PROTEIN_CLASS: 4.1.1.48

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AcrEF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DdpA and DdpB and DdpC and DdpD and DdpF ) or ( DppA and DppB and DppC and DppD and DppF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GmhA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ZnuA and ZnuB and ZnuC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GuaA

+

PROTEIN_CLASS: 6.3.5.2

+

SUBSYSTEM: S_Purine_and_Pyrimidine_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NupG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PlsB

+

PROTEIN_CLASS: 2.3.1.15

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( OmpN ) or ( OmpC ) or ( PhoE ) or ( OmpF )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CydC and CydD )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MhpT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: PlsB

+

PROTEIN_CLASS: 2.3.1.15

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: CitT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( Cls ) or ( YbhO )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AqpZ ) or ( SPONTANEOUS )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RibBec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( IdnK ) or ( GntK )

+

PROTEIN_CLASS: 2.7.1.12

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MhpC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.4.17.13

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: AtoB

+

PROTEIN_CLASS: 2.3.1.9

+

SUBSYSTEM: S_Membrane__Lipid_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PgpA ) or ( PgpB )

+

PROTEIN_CLASS: 3.1.3.27

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Gnd

+

PROTEIN_CLASS: 1.1.1.44

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PdxHec

+

PROTEIN_CLASS: 1.4.3.5

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: SelA

+

PROTEIN_CLASS: 2.9.1.1

+

SUBSYSTEM: S_tRNA_Charging

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ArsB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RpiB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( FadD ) or ( FadK )

+

PROTEIN_CLASS: 6.2.1.3

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ExuT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RibE

+

PROTEIN_CLASS: 2.5.1.9

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LpxH

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: HemCec

+

PROTEIN_CLASS: 4.3.1.8

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RibCec

+

PROTEIN_CLASS: 2.5.1.9

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Mtn

+

PROTEIN_CLASS: 3.2.2.16

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: EutBC

+

PROTEIN_CLASS: 4.3.1.7

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IdnD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YeaU

+

PROTEIN_CLASS: 1.1.1.83

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LamB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tsx

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UbiH

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GarP ) or ( GudP )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SotB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZntA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MdaB

+

PROTEIN_CLASS: 1.6.99.6

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MdaB

+

PROTEIN_CLASS: 1.6.99.6

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AmpG

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FruAec and FruBec and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MdaB

+

PROTEIN_CLASS: 1.6.99.6

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( SPONTANEOUS ) or ( AmtB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Cdd

+

PROTEIN_CLASS: 3.5.4.14

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( CycAec ) or ( YeaV )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MhpA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GarL

+

PROTEIN_CLASS: 4.1.2.20

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CysE

+

PROTEIN_CLASS: 2.3.1.30

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: UshA

+

PROTEIN_CLASS: 3.6.1.45

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: NanE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: TyrAec

+

PROTEIN_CLASS: 1.3.1.12

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Gmkec

+

PROTEIN_CLASS: 2.7.4.8

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( LivF and LivG and LivH and LivJ and LivM ) or ( LivF and LivG and LivH and LivK and LivM )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsB

+

PROTEIN_CLASS: 2.3.1.15

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: YmfB

+

PROTEIN_CLASS: 3.6.1.15

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PhnN

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GabP

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PabC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: KdgK

+

PROTEIN_CLASS: 2.7.1.45

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GarD

+

PROTEIN_CLASS: 4.2.1.42

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PlsB

+

PROTEIN_CLASS: 2.3.1.15

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PabA and PabBec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( KatE ) or ( KatG )

+

PROTEIN_CLASS: 1.11.1.6

+

SUBSYSTEM: S_Unassigned

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AlsA and AlsB and AlsC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MsbA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldB

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UshA ) or ( AphA )

+

PROTEIN_CLASS: 3.1.3.5

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpN ) or ( OmpF ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PflBec and YfiD ) or ( PflBec ) or ( TdcEec ) or ( PflDec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Pyruvate_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SPONTANEOUS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PfkA ) or ( PfkB )

+

PROTEIN_CLASS: 2.7.1.11

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AroK ) or ( AroL )

+

PROTEIN_CLASS: 2.7.1.71

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: MtlD

+

PROTEIN_CLASS: 1.1.1.17

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Idi

+

PROTEIN_CLASS: 5.3.3.2

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Eda

+

PROTEIN_CLASS: 4.1.1.3

+

SUBSYSTEM: S_Pyruvate_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LplT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CycAec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AppA

+

PROTEIN_CLASS: 3.6.1.15

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.4.17.13

+

SUBSYSTEM: S_Murein_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MhpD

+

PROTEIN_CLASS: 4.2.1.80

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ThiK

+

PROTEIN_CLASS: 2.7.1.89

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( ManX and ManY and ManZ and PtsH and PtsI )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: YjjL

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PtsH and PtsI and SgaA and SgaB and SgaT )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.4

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RfaEec

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: CysIJ

+

PROTEIN_CLASS: 1.8.2.2

+

SUBSYSTEM: S_Cysteine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Tsx

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: Udk

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Tpi

+

PROTEIN_CLASS: 5.3.1.1

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NanA

+

PROTEIN_CLASS: 4.1.3.3

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PspE

+

PROTEIN_CLASS: 2.8.1.1

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MalS

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PanF

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: HemL

+

PROTEIN_CLASS: 5.4.3.8

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: DctA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: AroA

+

PROTEIN_CLASS: 2.5.1.19

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NudE

+

PROTEIN_CLASS: 3.6.1.13

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( DkgA ) or ( DkgB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( YibO ) or ( GpmB ) or ( GpmA )

+

PROTEIN_CLASS: 5.4.2.1

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Pgl

+

PROTEIN_CLASS: 3.1.1.31

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Pgk

+

PROTEIN_CLASS: 2.7.2.3

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Pgi

+

PROTEIN_CLASS: 5.3.1.9

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( NapAB and NapC and NapG and NapH )

+

PROTEIN_CLASS: 1.7.99.4

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: WaaA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RibFec

+

PROTEIN_CLASS: 2.7.7.2

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AroF ) or ( AroGec ) or ( AroH )

+

PROTEIN_CLASS: 4.1.2.15

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Pck

+

PROTEIN_CLASS: 4.1.1.49

+

SUBSYSTEM: S_Anaplerotic__Reactions

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: RhaT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( HyaA ) or ( HybC )

+

PROTEIN_CLASS: 1.18.99.1

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TauD

+

PROTEIN_CLASS: 1.14.11.17

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: XdhABC

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nucleotide__Salvage_Pathway

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesA

+

PROTEIN_CLASS: 3.1.1.5

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TorYZ

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Oxidative_Phosphorylation

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: GltB

+

PROTEIN_CLASS: 1.4.1.13

+

SUBSYSTEM: S_Glutamate_metabolism

+ + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GlnHec and GlnPec and GlnQec )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS: 3.2.1.26

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( UgpA and UgpB and UgpC and UgpE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PldA

+

PROTEIN_CLASS: 3.1.1.32

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.9

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: FabI

+

PROTEIN_CLASS: 1.3.1.10

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MalE and MalF and MalG and MalK )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Glycerophospholipid_Metabolism

+ + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( GarP ) or ( GudP )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TktA ) or ( TktB )

+

PROTEIN_CLASS: 2.2.1.1

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TktA ) or ( TktB )

+

PROTEIN_CLASS: 2.2.1.1

+

SUBSYSTEM: S_Pentose_Phosphate_Pathway

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( IlvE ) or ( AspC ) or ( TyrB )

+

PROTEIN_CLASS: 2.6.1.58

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: TesB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_

+ + + + + + + + + +

PROTEIN_ASSOCIATION: ( UgpA and UgpB and UgpC and UgpE )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: IlvE

+

PROTEIN_CLASS: 2.6.1.42

+

SUBSYSTEM: S_Valine__Leucine_and_Isoleucine_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MhpE

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ZntA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Dfp

+

PROTEIN_CLASS: 4.1.1.36

+

SUBSYSTEM: S_Cofactor_and_Prosthetic_Group_Biosynthesis

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( FieF ) or ( ZitB )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Inorganic_Ion_Transport_and_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: Fcl

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Cell_Envelope_Biosynthesis

+ + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM: S__Lipopolysaccharide_Biosynthesis__Recycling

+ + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION:

+

PROTEIN_CLASS:

+

SUBSYSTEM:

+ + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: NrfABCD

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Nitrogen_Metabolism

+ + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( AceEec and AceFec and LpdA )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_GlycolysisGluconeogenesis

+ + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( TyrB ) or ( AspC )

+

PROTEIN_CLASS: 2.6.1.5

+

SUBSYSTEM: S_Tyrosine_Tryptophan_and_Phenylalanine_Metabolism

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: MhpT

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: SpeD

+

PROTEIN_CLASS: 4.1.1.50

+

SUBSYSTEM: S_Arginine_and_Proline_Metabolism

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: LdcA

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Murein__Recycling

+ + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( PhoE ) or ( OmpF ) or ( OmpN ) or ( OmpC )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Outer_Membrane_Porin

+ + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: ( MalE and MalF and MalG and MalK )

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Transport_Inner_Membrane

+ + + + + + + + + + + + + + + + + + + + + + + + + +

PROTEIN_ASSOCIATION: PuuB

+

PROTEIN_CLASS:

+

SUBSYSTEM: S_Alternate_Carbon_Metabolism

+ + + + + + + + + + + + + + + + + + + +

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Metabolic Engineering in Python Home-page: https://github.com/BioSystemsUM/mewpy/ Home-page: https://github.com/vmspereira/mewpy/ diff --git a/setup.cfg b/setup.cfg index c0d8a0e7..cd03bc49 100644 --- a/setup.cfg +++ b/setup.cfg @@ -1,5 +1,5 @@ [bumpversion] -current_version = 0.1.36 +current_version = 1.0.0 commit = True tag = False diff --git a/setup.py b/setup.py index 995848ae..24b43356 100644 --- a/setup.py +++ b/setup.py @@ -12,7 +12,7 @@ setup( name='mewpy', - version='0.1.36', + version='1.0.0', python_requires='>=3.6', package_dir={'': 'src'}, packages=find_packages('src'), diff --git a/src/mewpy/__init__.py b/src/mewpy/__init__.py index 8fa614e0..96872031 100644 --- a/src/mewpy/__init__.py +++ b/src/mewpy/__init__.py @@ -15,7 +15,7 @@ __author__ = 'Vitor Pereira (2019-) and CEB University of Minho (2019-2023)' __email__ = 'vpereira@ceb.uminho.pt' -__version__ = '0.1.36' +__version__ = '1.0.0' From 3bf69b0da74753358aa9feec0c0defa922ec56a2 Mon Sep 17 00:00:00 2001 From: Vitor Pereira Date: Sun, 15 Dec 2024 00:12:56 +0000 Subject: [PATCH 18/24] update action --- .github/workflows/main.yaml | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/.github/workflows/main.yaml b/.github/workflows/main.yaml index 38e53524..b1079a3d 100644 --- a/.github/workflows/main.yaml +++ b/.github/workflows/main.yaml @@ -18,7 +18,7 @@ jobs: fail-fast: false matrix: os: [ubuntu-latest, macos-latest, windows-latest] - python-version: [3.7] + python-version: [3.9] steps: - uses: actions/checkout@v2 From 90a9b91649ee9fa545e0052ccce57ae0e8cdd1f8 Mon Sep 17 00:00:00 2001 From: vpereira01 Date: Wed, 30 Jul 2025 17:39:41 +0100 Subject: [PATCH 19/24] update install and dependencies --- .github/workflows/ci.yml | 104 +++++++ .gitignore | 334 +++++++++++---------- MANIFEST.in | 18 +- pyproject.toml | 111 ++++++- requirements.txt | 8 +- setup.cfg | 60 +--- setup.py | 33 +- src/mewpy/optimization/jmetal/ea.py | 7 +- src/mewpy/optimization/jmetal/operators.py | 36 +-- src/mewpy/optimization/jmetal/problem.py | 61 +++- src/mewpy/simulation/reframed.py | 28 +- src/mewpy/simulation/simulator.py | 10 + tox.ini | 38 ++- 13 files changed, 551 insertions(+), 297 deletions(-) create mode 100644 .github/workflows/ci.yml diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml new file mode 100644 index 00000000..3ed94596 --- /dev/null +++ b/.github/workflows/ci.yml @@ -0,0 +1,104 @@ +name: CI + +on: + push: + branches: [ master, main, develop ] + pull_request: + branches: [ master, main, develop ] + +jobs: + test: + runs-on: ${{ matrix.os }} + strategy: + fail-fast: false + matrix: + os: [ubuntu-latest, windows-latest, macos-latest] + python-version: ["3.8", "3.9", "3.10", "3.11", "3.12"] + exclude: + # Reduce matrix size for faster builds + - os: windows-latest + python-version: "3.8" + - os: macos-latest + python-version: "3.8" + + steps: + - uses: actions/checkout@v4 + + - name: Set up Python ${{ matrix.python-version }} + uses: actions/setup-python@v4 + with: + python-version: ${{ matrix.python-version }} + + - name: Install dependencies + run: | + python -m pip install --upgrade pip + pip install build pytest pytest-cov + pip install -e .[test] + + - name: Run tests + run: | + pytest --cov=mewpy --cov-report=xml --cov-report=term-missing + + - name: Upload coverage to Codecov + if: matrix.os == 'ubuntu-latest' && matrix.python-version == '3.10' + uses: codecov/codecov-action@v3 + with: + file: ./coverage.xml + fail_ci_if_error: false + + lint: + runs-on: ubuntu-latest + steps: + - uses: actions/checkout@v4 + + - name: Set up Python + uses: actions/setup-python@v4 + with: + python-version: "3.10" + + - name: Install dependencies + run: | + python -m pip install --upgrade pip + pip install flake8 black isort + pip install -e . + + - name: Lint with flake8 + run: | + flake8 src tests + + - name: Check formatting with black + run: | + black --check src tests + + - name: Check import sorting with isort + run: | + isort --check-only src tests + + build: + runs-on: ubuntu-latest + steps: + - uses: actions/checkout@v4 + + - name: Set up Python + uses: actions/setup-python@v4 + with: + python-version: "3.10" + + - name: Install build dependencies + run: | + python -m pip install --upgrade pip + pip install build twine + + - name: Build package + run: | + python -m build + + - name: Check package + run: | + twine check dist/* + + - name: Upload artifacts + uses: actions/upload-artifact@v3 + with: + name: dist-files + path: dist/ diff --git a/.gitignore b/.gitignore index cf9fd44a..e89e3cf5 100644 --- a/.gitignore +++ b/.gitignore @@ -1,165 +1,177 @@ -.vscode/ -venv/ -__pycache__ -docs/build/ +# Byte-compiled / optimized / DLL files +__pycache__/ +*.py[cod] +*$py.class + +# C extensions +*.so + +# Distribution / packaging +.Python build/ -dist -.idea -mewpy.egg-info -examples/models/gecko/eciML1515_batch.xml -*.log -.tox -.eggs +develop-eggs/ +dist/ +downloads/ +eggs/ +.eggs/ +lib/ +lib64/ +parts/ +sdist/ +var/ +wheels/ +share/python-wheels/ +*.egg-info/ +.installed.cfg +*.egg +MANIFEST + +# PyInstaller +# Usually these files are written by a python script from a template +# before PyInstaller builds the exe, so as to inject date/other infos into it. +*.manifest +*.spec + +# Installer logs +pip-log.txt +pip-delete-this-directory.txt + +# Unit test / coverage reports +htmlcov/ +.tox/ +.nox/ .coverage -.pytest_cache -htmlcov -run_tox.sh -tests/reports/ +.coverage.* +.cache +nosetests.xml +coverage.xml +*.cover +*.py,cover +.hypothesis/ +.pytest_cache/ +cover/ + +# Translations +*.mo +*.pot + +# Django stuff: +*.log +local_settings.py +db.sqlite3 +db.sqlite3-journal + +# Flask stuff: +instance/ +.webassets-cache + +# Scrapy stuff: +.scrapy + +# Sphinx documentation +docs/_build/ +docs/build/ +builddoc/ + +# PyBuilder +.pybuilder/ +target/ + +# Jupyter Notebook .ipynb_checkpoints + +# IPython +profile_default/ +ipython_config.py + +# pyenv +# For a library or package, you might want to ignore these files since the code is +# intended to run in multiple environments; otherwise, check them in: +# .python-version + +# pipenv +# According to pypa/pipenv#598, it is recommended to include Pipfile.lock in version control. +# However, in case of collaboration, if having platform-specific dependencies or dependencies +# having no cross-platform support, pipenv may install dependencies that don't work, or not +# install all needed dependencies. +#Pipfile.lock + +# poetry +# Similar to Pipfile.lock, it is generally recommended to include poetry.lock in version control. +# This is especially recommended for binary packages to ensure reproducibility, and is more +# commonly ignored for libraries. +# https://python-poetry.org/docs/basic-usage/#commit-your-poetrylock-file-to-version-control +#poetry.lock + +# pdm +# Similar to Pipfile.lock, it is generally recommended to include pdm.lock in version control. +#pdm.lock +# pdm stores project-wide configurations in .pdm.toml, but it is recommended to not include it +# in version control. +# https://pdm.fming.dev/#use-with-ide +.pdm.toml + +# PEP 582; used by e.g. github.com/David-OConnor/pyflow and github.com/pdm-project/pdm +__pypackages__/ + +# Celery stuff +celerybeat-schedule +celerybeat.pid + +# SageMath parsed files +*.sage.py + +# Environments +.env +.venv +env/ +venv/ +ENV/ +env.bak/ +venv.bak/ + +# Spyder project settings +.spyderproject +.spyproject + +# Rope project settings +.ropeproject + +# mkdocs documentation +/site + +# mypy +.mypy_cache/ +.dmypy.json +dmypy.json + +# Pyre type checker +.pyre/ + +# pytype static type analyzer +.pytype/ + +# Cython debug symbols +cython_debug/ + +# PyCharm +# JetBrains specific template is maintained in a separate JetBrains.gitignore that can +# be added to the global gitignore or merged into this project gitignore. 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-builddoc/_static/css/fonts/fontawesome-webfont.svg -builddoc/_static/css/fonts/fontawesome-webfont.ttf -builddoc/_static/css/fonts/fontawesome-webfont.woff -builddoc/_static/css/fonts/fontawesome-webfont.woff2 -builddoc/_static/css/fonts/lato-bold-italic.woff -builddoc/_static/css/fonts/lato-bold-italic.woff2 -builddoc/_static/css/fonts/lato-bold.woff -builddoc/_static/css/fonts/lato-bold.woff2 -builddoc/_static/css/fonts/lato-normal-italic.woff -builddoc/_static/css/fonts/lato-normal-italic.woff2 -builddoc/_static/css/fonts/lato-normal.woff -builddoc/_static/css/fonts/lato-normal.woff2 -builddoc/_static/css/fonts/Roboto-Slab-Bold.woff -builddoc/_static/css/fonts/Roboto-Slab-Bold.woff2 -builddoc/_static/css/fonts/Roboto-Slab-Regular.woff -builddoc/_static/css/fonts/Roboto-Slab-Regular.woff2 -builddoc/_static/js/badge_only.js -builddoc/_static/js/html5shiv-printshiv.min.js -builddoc/_static/js/html5shiv.min.js -builddoc/_static/js/theme.js + +# Windows +Thumbs.db +ehthumbs.db +Desktop.ini + +# Project specific +tests/reports/ +examples/models/gecko/eciML1515_batch.xml +run_tox.sh diff --git a/MANIFEST.in b/MANIFEST.in index f66aed07..a3a29b32 100644 --- a/MANIFEST.in +++ b/MANIFEST.in @@ -1,8 +1,20 @@ include README.md include LICENSE +include requirements.txt +include pyproject.toml +# Include package data graft src/mewpy/model/data +recursive-include src/mewpy *.xml *.csv *.txt + +# Include documentation +recursive-include docs *.rst conf.py Makefile make.bat *.jpg *.png *.gif *.md + +# Include examples +recursive-include examples *.ipynb *.py *.md *.csv +graft examples/models + +# Exclude compiled Python files recursive-exclude * __pycache__ -recursive-exclude * *.py[co] -include mewpy/model/data/* -recursive-include docs *.rst conf.py Makefile make.bat *.jpg *.png *.gif \ No newline at end of file +recursive-exclude * *.py[co] +recursive-exclude * .DS_Store \ No newline at end of file diff --git a/pyproject.toml b/pyproject.toml index e8cf30ba..e245852c 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -1,5 +1,108 @@ [build-system] -# These are the assumed default build requirements from pip: -# https://pip.pypa.io/en/stable/reference/pip/#pep-517-and-518-support -requires = ["setuptools>=43.0.0", "wheel"] -build-backend = "setuptools.build_meta" \ No newline at end of file +requires = ["setuptools>=61.0.0", "wheel"] +build-backend = "setuptools.build_meta" + +[project] +name = "mewpy" +version = "1.0.0" +description = "MEWpy - Metabolic Engineering in Python" +readme = "README.md" +license = "GPL-3.0-or-later" +authors = [ + {name = "Vitor Pereira", email = "vmspereira@gmail.com"}, + {name = "BiSBII CEB University of Minho"}, +] +maintainers = [ + {name = "Vitor Pereira", email = "vmspereira@gmail.com"}, +] +keywords = [ + "metabolism", + "biology", + "constraint-based", + "optimization", + "flux-balance analysis", + "strain optimization" +] +classifiers = [ + "Development Status :: 5 - Production/Stable", + "Intended Audience :: Science/Research", + "Operating System :: OS Independent", + "Programming Language :: Python :: 3", + "Programming Language :: Python :: 3.8", + "Programming Language :: Python :: 3.9", + "Programming Language :: Python :: 3.10", + "Programming Language :: Python :: 3.11", + "Programming Language :: Python :: 3.12", + "Topic :: Scientific/Engineering :: Bio-Informatics", +] +requires-python = ">=3.8" +dependencies = [ + "numpy>=1.20,<1.24", + "cobra>=0.26.0,<0.27.0", + "reframed", + "inspyred", + "jmetalpy>=1.5.0", + "networkx", + "matplotlib>=3.5.0,<4.0.0", + "tqdm", + "joblib", + "httpx>=0.23.0,<0.24.0", + "pandas>=1.0,<2.0", +] + +[project.optional-dependencies] +test = [ + "pytest>=6.0", + "pytest-runner", + "cplex", + "tox", +] +dev = [ + "pytest>=6.0", + "pytest-runner", + "cplex", + "tox", + "flake8", + "black", + "isort", +] +docs = [ + "sphinx", + "sphinx-rtd-theme", +] + +[project.urls] +Homepage = "https://github.com/BioSystemsUM/mewpy/" +Repository = "https://github.com/vmspereira/mewpy/" +Development = "https://github.com/vmspereira/MEWpy" +Documentation = "https://mewpy.readthedocs.io" +Issues = "https://github.com/vmspereira/mewpy/issues" + +[tool.setuptools] +zip-safe = true +include-package-data = true + +[tool.setuptools.packages.find] +where = ["src"] + +[tool.setuptools.package-data] +mewpy = ["model/data/*"] +"*" = ["*.xml", "*.csv", "*.txt"] + +[tool.pytest.ini_options] +testpaths = ["tests"] +python_files = ["test_*.py"] +python_classes = ["Test*"] +python_functions = ["test_*"] + +[tool.flake8] +max-line-length = 120 +exclude = ["__init__.py", "docs"] + +[tool.black] +line-length = 120 +target-version = ["py38", "py39", "py310", "py311", "py312"] + +[tool.isort] +profile = "black" +line_length = 120 \ No newline at end of file diff --git a/requirements.txt b/requirements.txt index cf1d86e0..c5798f02 100644 --- a/requirements.txt +++ b/requirements.txt @@ -1,11 +1,11 @@ numpy -cobra<=0.26.2 +cobra>=0.26.0,<0.27.0 reframed inspyred -jmetalpy<=1.5.5 +jmetalpy>=1.5.0 networkx -matplotlib<=3.5.0 +matplotlib>=3.5.0,<4.0.0 tqdm joblib -httpx~=0.24.0 +httpx>=0.23.0,<0.24.0 diff --git a/setup.cfg b/setup.cfg index cd03bc49..04a9de16 100644 --- a/setup.cfg +++ b/setup.cfg @@ -1,56 +1,10 @@ +# Legacy setup.cfg - most configuration moved to pyproject.toml + [bumpversion] current_version = 1.0.0 commit = True tag = False -[metadata] -name = MEWpy -author = Vitor Pereira and BiSBII CEB University of Minho -description = Metabolic Enginneering Workbench -long_description = file: README.md -long_description_content_type = text/markdown -url = https://github.com/BioSystemsUM/mewpy -project_urls = - Development = https://github.com/vmspereira/MEWpy - Documentation = https://mewpy.readthedocs.io -classifiers = - Programming Language :: Python :: 3 - License :: OSI Approved :: Apache Software License - Operating System :: OS Independent -keywords = - metabolism - biology - constraint-based - optimization - flux-balance analysis - -[options] -zip_safe = True -install_requires = - cobra<=0.26.2 - reframed - inspyred - jmetalpy<=1.5.5 - networkx - matplotlib<=3.5.0 - tqdm - joblib - httpx~=0.24 -tests_require = - tox - cplex -packages = find: -package_dir = - = src - -[options.package_data] -mewpy = - model/data/* -* = *.xml, *.csv, *.txt - -[bdist_wheel] -universal = 1 - [bumpversion:file:setup.py] search = version='{current_version}' replace = version='{new_version}' @@ -59,12 +13,12 @@ replace = version='{new_version}' search = __version__ = '{current_version}' replace = __version__ = '{new_version}' -[flake8] -max-line-length = 120 -exclude = __init__.py,docs +[bumpversion:file:pyproject.toml] +search = version = "{current_version}" +replace = version = "{new_version}" -[aliases] -test = pytest +[bdist_wheel] +universal = 0 [egg_info] tag_build = diff --git a/setup.py b/setup.py index 24b43356..25a0c3ee 100644 --- a/setup.py +++ b/setup.py @@ -1,31 +1,6 @@ -from setuptools import setup, find_packages +# Legacy setup.py for compatibility +# All configuration has been moved to pyproject.toml -files = ["model/data/*"] +from setuptools import setup -requirements = ['cobra', 'inspyred', 'jmetalpy<=1.5.5', - 'reframed', 'networkx', 'matplotlib<=3.5.0', - 'joblib', 'tdqm', 'httpx<=0.23.0'] - -setup_requirements = requirements + ['pytest-runner'] -test_requirements = requirements + ['pytest', 'cplex'] -install_requirements = requirements - -setup( - name='mewpy', - version='1.0.0', - python_requires='>=3.6', - package_dir={'': 'src'}, - packages=find_packages('src'), - package_data={"": ["*.xml", "*.csv", "*.txt"], 'mewpy': files}, - include_package_data=True, - zip_safe=False, - install_requires=install_requirements, - setup_requires=setup_requirements, - tests_require=test_requirements, - author='Vitor Pereira and BiSBII CEB University of Minho', - description='MEWpy - Metabolic Engineering in Python ', - license='GPL v3 License', - keywords='strain optimization', - url='https://github.com/BioSystemsUM/mewpy/', - test_suite='tests', -) +setup() diff --git a/src/mewpy/optimization/jmetal/ea.py b/src/mewpy/optimization/jmetal/ea.py index 07a92a3c..5c24a94b 100644 --- a/src/mewpy/optimization/jmetal/ea.py +++ b/src/mewpy/optimization/jmetal/ea.py @@ -91,10 +91,11 @@ def _run_so(self): self.ea_problem.reset_initial_population_counter() if self.algorithm_name == 'SA': print("Running SA") + # For SA, set mutation probability to 1.0 self.mutation.probability = 1.0 algorithm = SimulatedAnnealing( problem=self.ea_problem, - mutation=self.mutation.probability, + mutation=self.mutation, termination_criterion=StoppingByEvaluations(max_evaluations=self.max_evaluations) ) @@ -130,8 +131,10 @@ def _run_mo(self): f = moea_map[self.algorithm_name] else: if self.ea_problem.number_of_objectives > 2: - self.algorithm_name == 'NSGAIII' + self.algorithm_name = 'NSGAIII' + f = moea_map['NSGAIII'] else: + self.algorithm_name = 'SPEA2' f = moea_map['SPEA2'] args = { diff --git a/src/mewpy/optimization/jmetal/operators.py b/src/mewpy/optimization/jmetal/operators.py index f11a1a8e..1dca7a28 100644 --- a/src/mewpy/optimization/jmetal/operators.py +++ b/src/mewpy/optimization/jmetal/operators.py @@ -52,12 +52,12 @@ def execute(self, solution: Solution) -> Solution: :returns: A mutated solution. """ - if random.random() <= self.probability and solution.number_of_variables > self.min_size: + if random.random() <= self.probability and len(solution.variables) > self.min_size: var = copy.copy(solution.variables) index = random.randint(0, len(var) - 1) del var[index] solution.variables = var - solution.number_of_variables = len(var) + # Note: number_of_variables is not stored in new jmetalpy, length is implicit return solution def get_name(self): @@ -84,7 +84,7 @@ def execute(self, solution: Solution) -> Solution: :returns: A mutated solution. """ - if random.random() <= self.probability and solution.number_of_variables < self.max_size: + if random.random() <= self.probability and len(solution.variables) < self.max_size: mutant = copy.copy(solution.variables) idx = random.randint(solution.lower_bound, solution.upper_bound) while idx in mutant: @@ -93,7 +93,7 @@ def execute(self, solution: Solution) -> Solution: idx = solution.lower_bound mutant.append(idx) solution.variables = mutant - solution.number_of_variables = len(mutant) + # Note: number_of_variables is not stored in new jmetalpy, length is implicit return solution def get_name(self): @@ -120,7 +120,7 @@ def execute(self, solution: Solution) -> Solution: :returns: A mutated solution. """ - if random.random() <= self.probability and solution.number_of_variables < self.max_size: + if random.random() <= self.probability and len(solution.variables) < self.max_size: mutant = copy.copy(solution.variables) idx = random.randint(solution.lower_bound[0], solution.upper_bound[0]) idxs = [a for (a, b) in mutant] @@ -131,7 +131,7 @@ def execute(self, solution: Solution) -> Solution: lv = random.randint(solution.lower_bound[1], solution.upper_bound[1]) mutant.append((idx, lv)) solution.variables = mutant - solution.number_of_variables = len(mutant) + # Variable count is now implicit from len(solution.variables) return solution def get_name(self): @@ -157,7 +157,7 @@ def execute(self, parents: List[KOSolution]) -> List[KOSolution]: offspring = [copy.deepcopy(parents[0]), copy.deepcopy(parents[1])] if random.random() <= self.probability and ( - offspring[0].number_of_variables > 1 or offspring[1].number_of_variables > 1): + len(offspring[0].variables) > 1 or len(offspring[1].variables) > 1): mom = set(copy.copy(offspring[0].variables)) dad = set(copy.copy(offspring[1].variables)) intersection = mom & dad @@ -180,9 +180,9 @@ def execute(self, parents: List[KOSolution]) -> List[KOSolution]: otherElems.pop(elemPosition) offspring[0].variables = list(child1) - offspring[0].number_of_variables = len(child1) + # Variable count is now implicit from len(offspring[0].variables) offspring[1].variables = list(child2) - offspring[1].number_of_variables = len(child2) + # Variable count is now implicit from len(offspring[1].variables) return offspring def get_number_of_parents(self) -> int: @@ -236,7 +236,7 @@ def execute(self, parents: List[OUSolution]) -> List[OUSolution]: offspring = [copy.deepcopy(parents[0]), copy.deepcopy(parents[1])] if random.random() <= self.probability and ( - offspring[0].number_of_variables > 1 or offspring[1].number_of_variables > 1): + len(offspring[0].variables) > 1 or len(offspring[1].variables) > 1): mom = set(copy.copy(offspring[0].variables)) dad = set(copy.copy(offspring[1].variables)) @@ -265,9 +265,9 @@ def execute(self, parents: List[OUSolution]) -> List[OUSolution]: child1.add(elem) offspring[0].variables = list(child1) - offspring[0].number_of_variables = len(child1) + # Variable count is now implicit from len(offspring[0].variables) offspring[1].variables = list(child2) - offspring[1].number_of_variables = len(child2) + # Variable count is now implicit from len(offspring[1].variables) return offspring def get_number_of_parents(self) -> int: @@ -290,7 +290,7 @@ def __init__(self, probability: float = 0.1): def execute(self, solution: Solution) -> Solution: n = solution.upper_bound-solution.lower_bound+1 - if random.random() <= self.probability and solution.number_of_variables < n: + if random.random() <= self.probability and len(solution.variables) < n: mutant = copy.copy(solution.variables) index = random.randint(0, len(mutant) - 1) idx = random.randint(solution.lower_bound, solution.upper_bound) @@ -316,7 +316,7 @@ def __init__(self, probability: float = 0.1): def execute(self, solution: Solution) -> Solution: n = solution.upper_bound[0]-solution.lower_bound[0]+1 - if random.random() <= self.probability and solution.number_of_variables < n: + if random.random() <= self.probability and len(solution.variables) < n: mutant = copy.copy(solution.variables) lix = [i for (i, j) in mutant] index = random.randint(0, len(mutant) - 1) @@ -409,7 +409,7 @@ def execute(self, parents: List[Solution]) -> List[Solution]: offspring = [copy.deepcopy(parents[0]), copy.deepcopy(parents[1])] if random.random() <= self.probability and ( - offspring[0].number_of_variables > 1 or offspring[1].number_of_variables > 1): + len(offspring[0].variables) > 1 or len(offspring[1].variables) > 1): mom = copy.copy(offspring[0].variables) dad = copy.copy(offspring[1].variables) child1 = [] @@ -423,9 +423,9 @@ def execute(self, parents: List[Solution]) -> List[Solution]: child2.append(mom[p]) offspring[0].variables = list(child1) - offspring[0].number_of_variables = len(child1) + # Variable count is now implicit from len(offspring[0].variables) offspring[1].variables = list(child2) - offspring[1].number_of_variables = len(child2) + # Variable count is now implicit from len(offspring[1].variables) return offspring def get_number_of_parents(self) -> int: @@ -448,7 +448,7 @@ def __init__(self, probability: float = 0.1): def execute(self, solution: Solution) -> Solution: if random.random() <= self.probability: - index = random.randint(0, solution.number_of_variables - 1) + index = random.randint(0, len(solution.variables) - 1) solution.variables[index] = solution.lower_bound[index] + \ (solution.upper_bound[index] - solution.lower_bound[index]) * random.random() return solution diff --git a/src/mewpy/optimization/jmetal/problem.py b/src/mewpy/optimization/jmetal/problem.py index 5c359aa9..496f340b 100644 --- a/src/mewpy/optimization/jmetal/problem.py +++ b/src/mewpy/optimization/jmetal/problem.py @@ -170,7 +170,19 @@ def __init__(self, problem, initial_polulation): so that it can be used in jMetal. """ self.problem = problem - self.number_of_objectives = len(self.problem.fevaluation) + self._number_of_objectives = len(self.problem.fevaluation) + # Handle different bounder types + try: + if hasattr(self.problem.bounder, 'upper_bound') and hasattr(self.problem.bounder, 'lower_bound'): + if isinstance(self.problem.bounder.upper_bound, int) and isinstance(self.problem.bounder.lower_bound, int): + self._number_of_variables = self.problem.bounder.upper_bound - self.problem.bounder.lower_bound + 1 + else: + self._number_of_variables = 100 # Default fallback + else: + self._number_of_variables = 100 # Default fallback + except: + self._number_of_variables = 100 # Default fallback + self._number_of_constraints = 0 self.obj_directions = [] self.obj_labels = [] for f in self.problem.fevaluation: @@ -182,6 +194,22 @@ def __init__(self, problem, initial_polulation): self.initial_polulation = initial_polulation self.__next_ini_sol = 0 + @property + def name(self) -> str: + return self.problem.get_name() + + @property + def number_of_objectives(self) -> int: + return self._number_of_objectives + + @property + def number_of_variables(self) -> int: + return self._number_of_variables + + @property + def number_of_constraints(self) -> int: + return self._number_of_constraints + def create_solution(self) -> KOSolution: solution = None flag = False @@ -200,7 +228,7 @@ def create_solution(self) -> KOSolution: self.problem.bounder.lower_bound, self.problem.bounder.upper_bound, len(solution), - self.problem.number_of_objectives) + self._number_of_objectives) new_solution.variables = list(solution)[:] return new_solution @@ -247,7 +275,16 @@ def __init__(self, problem, initial_polulation=[]): so that it can be used in jMetal. """ self.problem = problem - self.number_of_objectives = len(self.problem.fevaluation) + self._number_of_objectives = len(self.problem.fevaluation) + # Handle different bounder types for OU problems + try: + if hasattr(self.problem.bounder, 'lower_bound') and isinstance(self.problem.bounder.lower_bound, (list, tuple)): + self._number_of_variables = len(self.problem.bounder.lower_bound) + else: + self._number_of_variables = 100 # Default fallback + except: + self._number_of_variables = 100 # Default fallback + self._number_of_constraints = 0 self.obj_directions = [] self.obj_labels = [] for f in self.problem.fevaluation: @@ -259,6 +296,22 @@ def __init__(self, problem, initial_polulation=[]): self.initial_polulation = initial_polulation self.__next_ini_sol = 0 + @property + def name(self) -> str: + return self.problem.get_name() + + @property + def number_of_objectives(self) -> int: + return self._number_of_objectives + + @property + def number_of_variables(self) -> int: + return self._number_of_variables + + @property + def number_of_constraints(self) -> int: + return self._number_of_constraints + def create_solution(self) -> OUSolution: solution = None flag = False @@ -277,7 +330,7 @@ def create_solution(self) -> OUSolution: self.problem.bounder.lower_bound, self.problem.bounder.upper_bound, len(solution), - self.problem.number_of_objectives) + self._number_of_objectives) new_solution.variables = list(solution)[:] return new_solution diff --git a/src/mewpy/simulation/reframed.py b/src/mewpy/simulation/reframed.py index 2edbae71..4d2c3d2c 100644 --- a/src/mewpy/simulation/reframed.py +++ b/src/mewpy/simulation/reframed.py @@ -26,7 +26,18 @@ from collections import OrderedDict import numpy as np -from reframed.cobra.simulation import FBA, pFBA, MOMA, lMOMA, ROOM +# Try to import available simulation methods from reframed +try: + from reframed.cobra.simulation import FBA, pFBA, lMOMA, ROOM + # Try to import MOMA if available + try: + from reframed.cobra.simulation import MOMA + except ImportError: + # MOMA not available in this version, use lMOMA as fallback + MOMA = lMOMA +except ImportError as e: + raise ImportError(f"Failed to import required reframed simulation methods: {e}") + from reframed.core.cbmodel import CBModel from reframed.solvers import set_default_solver from reframed.solvers import solver_instance @@ -43,7 +54,7 @@ LOGGER = logging.getLogger(__name__) -solver_map = {'gurobi': 'gurobi', 'cplex': 'cplex', 'glpk': 'optlang'} +solver_map = {'gurobi': 'gurobi', 'cplex': 'cplex', 'glpk': 'scip', 'scip': 'scip'} reaction_type_map = { "ENZ": ReactionType.ENZYMATIC, @@ -191,7 +202,18 @@ def __init__(self, model: CBModel, "Model is None or is not an instance of REFRAMED CBModel") self.model = model - set_default_solver(solver_map[get_default_solver()]) + + # Set the solver, with fallback to default reframed solver + try: + default_solver = get_default_solver() + if default_solver in solver_map: + set_default_solver(solver_map[default_solver]) + else: + # Use reframed's default solver if MEWpy's default is not mapped + pass # reframed will use its default + except Exception: + # If setting the solver fails, just use reframed's default + pass # keep track on reaction bounds changes self._environmental_conditions = OrderedDict() if envcond is None else envcond self._constraints = dict() if constraints is None else { diff --git a/src/mewpy/simulation/simulator.py b/src/mewpy/simulation/simulator.py index d7f625a6..a53c5792 100644 --- a/src/mewpy/simulation/simulator.py +++ b/src/mewpy/simulation/simulator.py @@ -58,6 +58,7 @@ def get_simulator(model, envcond=None, constraints=None, reference=None, reset_s instance = None name = f"{model.__class__.__module__}.{model.__class__.__name__}" + if name in map_model_simulator: module_name, class_name = map_model_simulator[name] module = __import__(module_name, fromlist=[None]) @@ -85,6 +86,7 @@ def get_simulator(model, envcond=None, constraints=None, reference=None, reset_s except Exception: raise RuntimeError("Could not create simulator for the ETFL model") else: + # Try COBRA models first try: from cobra.core.model import Model if isinstance(model, Model): @@ -94,6 +96,11 @@ def get_simulator(model, envcond=None, constraints=None, reference=None, reset_s model, envcond=envcond, constraints=constraints, reference=reference, reset_solver=reset_solver) except ImportError: pass + except Exception: + # Silently continue to try other simulator types + pass + + # Try REFRAMED models if COBRA failed if not instance: try: from reframed.core.cbmodel import CBModel @@ -103,6 +110,9 @@ def get_simulator(model, envcond=None, constraints=None, reference=None, reset_s model, envcond=envcond, constraints=constraints, reference=reference, reset_solver=reset_solver) except ImportError: pass + except Exception as e: + # Re-raise the exception to help with debugging + raise RuntimeError(f"Failed to create simulator for REFRAMED model: {e}") if not instance: raise ValueError(f"The model <{name}> has no defined simulator.") diff --git a/tox.ini b/tox.ini index 2d4c5455..c5f026a9 100644 --- a/tox.ini +++ b/tox.ini @@ -1,28 +1,26 @@ [tox] -envlist = py3{7,8,9} +envlist = py3{8,9,10,11,12} +isolated_build = true [gh-actions] python = - 3.7: py37 3.8: py38 3.9: py39 + 3.10: py310 + 3.11: py311 + 3.12: py312 [testenv] setenv = - PYTHONPATH = {toxinidir} - -deps = pytest - pytest-cov - cplex - - + PYTHONPATH = {toxinidir} +deps = + pytest>=6.0 + pytest-cov + cplex +extras = test commands = pytest --cov=mewpy --cov-report=term --cov-report=xml -[testenv:begin] -commands = coverage erase - - [testenv:flake8] basepython = python3 skip_install = true @@ -34,7 +32,13 @@ deps = flake8-typing-imports>=1.1 pep8-naming commands = - flake8 src tests setup.py + flake8 src tests + +[testenv:black] +basepython = python3 +skip_install = true +deps = black +commands = black --check src tests [testenv:pylint] basepython = python3 @@ -45,7 +49,9 @@ deps = commands = pylint src -[testenv:end] +[testenv:docs] +basepython = python3 +extras = docs commands = - coverage report --omit='.tox/*' + sphinx-build -W -b html docs docs/_build/html coverage html --omit='.tox/*' From 3213fa6ef0bfbbb632f388471590f806d6392d01 Mon Sep 17 00:00:00 2001 From: vpereira01 Date: Wed, 30 Jul 2025 18:07:07 +0100 Subject: [PATCH 20/24] update artifacts version --- .github/workflows/ci.yml | 11 ++++++----- 1 file changed, 6 insertions(+), 5 deletions(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 3ed94596..1aae2b6e 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -25,7 +25,7 @@ jobs: - uses: actions/checkout@v4 - name: Set up Python ${{ matrix.python-version }} - uses: actions/setup-python@v4 + uses: actions/setup-python@v5 with: python-version: ${{ matrix.python-version }} @@ -41,10 +41,11 @@ jobs: - name: Upload coverage to Codecov if: matrix.os == 'ubuntu-latest' && matrix.python-version == '3.10' - uses: codecov/codecov-action@v3 + uses: codecov/codecov-action@v4 with: file: ./coverage.xml fail_ci_if_error: false + token: ${{ secrets.CODECOV_TOKEN }} lint: runs-on: ubuntu-latest @@ -52,7 +53,7 @@ jobs: - uses: actions/checkout@v4 - name: Set up Python - uses: actions/setup-python@v4 + uses: actions/setup-python@v5 with: python-version: "3.10" @@ -80,7 +81,7 @@ jobs: - uses: actions/checkout@v4 - name: Set up Python - uses: actions/setup-python@v4 + uses: actions/setup-python@v5 with: python-version: "3.10" @@ -98,7 +99,7 @@ jobs: twine check dist/* - name: Upload artifacts - uses: actions/upload-artifact@v3 + uses: actions/upload-artifact@v4 with: name: dist-files path: dist/ From 3b9243e19fb4fa47ddcacad5f18b710db12f4991 Mon Sep 17 00:00:00 2001 From: vpereira01 Date: Wed, 30 Jul 2025 18:15:41 +0100 Subject: [PATCH 21/24] update tox & CI --- .github/workflows/ci.yml | 6 +++--- tox.ini | 6 ++---- 2 files changed, 5 insertions(+), 7 deletions(-) diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml index 1aae2b6e..2003fc56 100644 --- a/.github/workflows/ci.yml +++ b/.github/workflows/ci.yml @@ -13,13 +13,13 @@ jobs: fail-fast: false matrix: os: [ubuntu-latest, windows-latest, macos-latest] - python-version: ["3.8", "3.9", "3.10", "3.11", "3.12"] + python-version: ["3.9", "3.10", "3.11"] exclude: # Reduce matrix size for faster builds - os: windows-latest - python-version: "3.8" + python-version: "3.9" - os: macos-latest - python-version: "3.8" + python-version: "3.9" steps: - uses: actions/checkout@v4 diff --git a/tox.ini b/tox.ini index c5f026a9..392b807e 100644 --- a/tox.ini +++ b/tox.ini @@ -1,15 +1,13 @@ [tox] -envlist = py3{8,9,10,11,12} +envlist = py3{9,10,11} isolated_build = true [gh-actions] python = - 3.8: py38 3.9: py39 3.10: py310 3.11: py311 - 3.12: py312 - + [testenv] setenv = PYTHONPATH = {toxinidir} From 24a0031efcf2ddc2325828f0386dd776af658fbf Mon Sep 17 00:00:00 2001 From: vpereira01 Date: Mon, 24 Nov 2025 23:14:36 +0000 Subject: [PATCH 22/24] fix dependencies --- pyproject.toml | 17 ++++++++++++----- requirements.txt | 9 +++++---- 2 files changed, 17 insertions(+), 9 deletions(-) diff --git a/pyproject.toml b/pyproject.toml index e245852c..df1e680c 100644 --- a/pyproject.toml +++ b/pyproject.toml @@ -37,25 +37,32 @@ classifiers = [ ] requires-python = ">=3.8" dependencies = [ - "numpy>=1.20,<1.24", - "cobra>=0.26.0,<0.27.0", + "numpy>=1.26.0", + "cobra", "reframed", "inspyred", "jmetalpy>=1.5.0", "networkx", - "matplotlib>=3.5.0,<4.0.0", + "matplotlib", "tqdm", "joblib", - "httpx>=0.23.0,<0.24.0", - "pandas>=1.0,<2.0", + "httpx", + "pandas", ] [project.optional-dependencies] +scip = [ + "pyscipopt>=5.0.0", +] +solvers = [ + "pyscipopt>=5.0.0", +] test = [ "pytest>=6.0", "pytest-runner", "cplex", "tox", + "pyscipopt>=5.0.0", ] dev = [ "pytest>=6.0", diff --git a/requirements.txt b/requirements.txt index c5798f02..779fa111 100644 --- a/requirements.txt +++ b/requirements.txt @@ -1,11 +1,12 @@ -numpy -cobra>=0.26.0,<0.27.0 +numpy>=1.26.0 +cobra reframed inspyred jmetalpy>=1.5.0 networkx -matplotlib>=3.5.0,<4.0.0 +matplotlib tqdm joblib -httpx>=0.23.0,<0.24.0 +httpx +pandas From 9999a7e4820394d3f1b3a998a215721ef3cb389b Mon Sep 17 00:00:00 2001 From: vpereira01 Date: Mon, 24 Nov 2025 23:15:30 +0000 Subject: [PATCH 23/24] add PySCIPOpt support --- src/mewpy/solvers/__init__.py | 32 +- src/mewpy/solvers/optlang_solver.py | 97 +++-- src/mewpy/solvers/pyscipopt_solver.py | 503 ++++++++++++++++++++++++++ src/mewpy/solvers/sglobal.py | 29 +- 4 files changed, 607 insertions(+), 54 deletions(-) create mode 100644 src/mewpy/solvers/pyscipopt_solver.py diff --git a/src/mewpy/solvers/__init__.py b/src/mewpy/solvers/__init__.py index 6e382544..4dda8dc6 100644 --- a/src/mewpy/solvers/__init__.py +++ b/src/mewpy/solvers/__init__.py @@ -5,8 +5,8 @@ Author: Vitor Pereira ############################################################################## """ -from .ode import (ODEMethod, SolverConfigurations, ODEStatus, - KineticConfigurations) + +from .ode import ODEMethod, SolverConfigurations, ODEStatus, KineticConfigurations from .solution import Solution, Status from .sglobal import __MEWPY_solvers__, __MEWPY_ode_solvers__ @@ -24,7 +24,7 @@ def get_default_solver(): if default_solver: return default_solver - solver_order = ['cplex', 'gurobi', 'optlang'] + solver_order = ["cplex", "gurobi", "pyscipopt", "optlang"] for solver in solver_order: if solver in list(__MEWPY_solvers__.keys()): @@ -37,9 +37,8 @@ def get_default_solver(): return default_solver - def set_default_solver(solvername): - """ Sets default solver. + """Sets default solver. Arguments: solvername : (str) solver name (currently available: 'gurobi', 'cplex') @@ -52,11 +51,13 @@ def set_default_solver(solvername): else: raise RuntimeError(f"Solver {solvername} not available.") + def solvers(): return list(__MEWPY_solvers__.keys()) + def solver_instance(model=None): - """ Returns a new instance of the currently selected solver. + """Returns a new instance of the currently selected solver. Arguments: model : COBRApy/REFRAMED model or a Simulator (optional) -- immediatly instantiate problem with given model @@ -70,29 +71,32 @@ def solver_instance(model=None): if solver: return __MEWPY_solvers__[solver](model) + # ################################################# # ODE solvers # ################################################# - try: from .scikits_solver import ScikitsODESolver - __MEWPY_ode_solvers__['scikits'] = ScikitsODESolver + + __MEWPY_ode_solvers__["scikits"] = ScikitsODESolver except ImportError: pass try: from .scipy_solver import ScipySolver - __MEWPY_ode_solvers__['scipy'] = ScipySolver + + __MEWPY_ode_solvers__["scipy"] = ScipySolver except ImportError: pass try: from .odespy_solver import ODESpySolver - __MEWPY_ode_solvers__['odespy'] = ODESpySolver + + __MEWPY_ode_solvers__["odespy"] = ODESpySolver except ImportError: pass @@ -106,7 +110,7 @@ def get_default_ode_solver(): if default_ode_solver: return default_ode_solver - ode_solver_order = ['scikits', 'scipy', 'odespy'] + ode_solver_order = ["scikits", "scipy", "odespy"] for solver in ode_solver_order: if solver in list(__MEWPY_ode_solvers__.keys()): @@ -120,7 +124,7 @@ def get_default_ode_solver(): def set_default_ode_solver(solvername): - """ Sets default solver. + """Sets default solver. Arguments: solvername : (str) solver name (currently available: 'gurobi', 'cplex') @@ -133,11 +137,13 @@ def set_default_ode_solver(solvername): else: raise RuntimeError(f"ODE solver {solvername} not available.") + def ode_solvers(): return list(__MEWPY_ode_solvers__.keys()) + def ode_solver_instance(func, method: ODEMethod): - """ Returns a new instance of the currently selected solver. + """Returns a new instance of the currently selected solver. Arguments: func : a function diff --git a/src/mewpy/solvers/optlang_solver.py b/src/mewpy/solvers/optlang_solver.py index e44e2ec4..80f89257 100644 --- a/src/mewpy/solvers/optlang_solver.py +++ b/src/mewpy/solvers/optlang_solver.py @@ -30,16 +30,16 @@ status_mapping = { - 'optimal': Status.OPTIMAL, - 'unbounded': Status.UNBOUNDED, - 'infeasible': Status.INFEASIBLE, - 'infeasible_or_unbounded': Status.INF_OR_UNB, - 'suboptimal': Status.SUBOPTIMAL, + "optimal": Status.OPTIMAL, + "unbounded": Status.UNBOUNDED, + "infeasible": Status.INFEASIBLE, + "infeasible_or_unbounded": Status.INF_OR_UNB, + "suboptimal": Status.SUBOPTIMAL, } class OptLangSolver(Solver): - """ Implements the gurobi solver interface. """ + """Implements the gurobi solver interface.""" def __init__(self, model=None): Solver.__init__(self) @@ -47,9 +47,9 @@ def __init__(self, model=None): self.parameter_mapping = { Parameter.TIME_LIMIT: self.problem.configuration.timeout, - #Parameter.FEASIBILITY_TOL: self.problem.configuration.tolerances.feasibility, + # Parameter.FEASIBILITY_TOL: self.problem.configuration.tolerances.feasibility, # Parameter.OPTIMALITY_TOL: self.problem.configuration.tolerances.optimality, - #Parameter.INT_FEASIBILITY_TOL: self.problem.configuration.tolerances.integrality, + # Parameter.INT_FEASIBILITY_TOL: self.problem.configuration.tolerances.integrality, } self.set_parameters(default_parameters) @@ -59,7 +59,7 @@ def __init__(self, model=None): self.build_problem(model) def add_variable(self, var_id, lb=-inf, ub=inf, vartype=VarType.CONTINUOUS, update=True): - """ Add a variable to the current problem. + """Add a variable to the current problem. Arguments: var_id (str): variable identifier @@ -96,8 +96,8 @@ def set_variable_bounds(self, var_id, lb, ub): if ub: var.ub = ub - def add_constraint(self, constr_id, lhs, sense='=', rhs=0, update=True): - """ Add a constraint to the current problem. + def add_constraint(self, constr_id, lhs, sense="=", rhs=0, update=True): + """Add a constraint to the current problem. Arguments: constr_id (str): constraint identifier @@ -110,11 +110,11 @@ def add_constraint(self, constr_id, lhs, sense='=', rhs=0, update=True): if constr_id in self.constr_ids: self.problem.remove(constr_id) - if sense == '=': + if sense == "=": constr = Constraint(Zero, lb=rhs, ub=rhs, name=constr_id) - elif sense == '>': + elif sense == ">": constr = Constraint(Zero, lb=rhs, name=constr_id) - elif sense == '<': + elif sense == "<": constr = Constraint(Zero, ub=rhs, name=constr_id) else: raise RuntimeError(f"Invalid constraint direction: {sense}") @@ -129,7 +129,7 @@ def add_constraint(self, constr_id, lhs, sense='=', rhs=0, update=True): self.problem.update() def remove_variable(self, var_id): - """ Remove a variable from the current problem. + """Remove a variable from the current problem. Arguments: var_id (str): variable identifier @@ -137,7 +137,7 @@ def remove_variable(self, var_id): self.remove_variables([var_id]) def remove_variables(self, var_ids): - """ Remove variables from the current problem. + """Remove variables from the current problem. Arguments: var_ids (list): variable identifiers @@ -149,7 +149,7 @@ def remove_variables(self, var_ids): self.var_ids.remove(var_id) def remove_constraint(self, constr_id): - """ Remove a constraint from the current problem. + """Remove a constraint from the current problem. Arguments: constr_id (str): constraint identifier @@ -157,7 +157,7 @@ def remove_constraint(self, constr_id): self.remove_constraints([constr_id]) def remove_constraints(self, constr_ids): - """ Remove constraints from the current problem. + """Remove constraints from the current problem. Arguments: constr_ids (list): constraint identifiers @@ -169,7 +169,7 @@ def remove_constraints(self, constr_ids): self.constr_ids.remove(constr_id) def set_objective(self, linear=None, quadratic=None, minimize=True): - """ Set a predefined objective for this problem. + """Set a predefined objective for this problem. Args: linear (dict): linear coefficients (optional) @@ -201,7 +201,7 @@ def set_objective(self, linear=None, quadratic=None, minimize=True): elif val != 0: objective[self.problem.variables[r_id]] = val - self.problem.objective = Objective(Zero, direction=('min' if minimize else 'max'), sloppy=True) + self.problem.objective = Objective(Zero, direction=("min" if minimize else "max"), sloppy=True) self.problem.objective.set_linear_coefficients(objective) else: objective = [] @@ -221,11 +221,22 @@ def set_objective(self, linear=None, quadratic=None, minimize=True): objective.append(val * self.problem.variables[r_id1] * self.problem.variables[r_id2]) objective_expr = add(objective) - self.problem.objective = Objective(objective_expr, direction=('min' if minimize else 'max'), sloppy=True) - - def solve(self, linear=None, quadratic=None, minimize=None, model=None, constraints=None, get_values=True, - shadow_prices=False, reduced_costs=False, pool_size=0, pool_gap=None): - """ Solve the optimization problem. + self.problem.objective = Objective(objective_expr, direction=("min" if minimize else "max"), sloppy=True) + + def solve( + self, + linear=None, + quadratic=None, + minimize=None, + model=None, + constraints=None, + get_values=True, + shadow_prices=False, + reduced_costs=False, + pool_size=0, + pool_gap=None, + ): + """Solve the optimization problem. Arguments: linear (str or dict): linear coefficients (or a single variable to optimize) @@ -255,7 +266,19 @@ def solve(self, linear=None, quadratic=None, minimize=None, model=None, constrai if r_id in self.var_ids: lpvar = problem.variables[r_id] old_constraints[r_id] = (lpvar.lb, lpvar.ub) - lpvar.lb, lpvar.ub = lb, ub + # Set bounds in safe order to avoid lb > ub validation errors + if lb > lpvar.ub: + # New lb is larger than current ub, set ub first + lpvar.ub = ub + lpvar.lb = lb + elif ub < lpvar.lb: + # New ub is smaller than current lb, set lb first + lpvar.lb = lb + lpvar.ub = ub + else: + # Safe to set in normal order + lpvar.lb = lb + lpvar.ub = ub else: warn(f"Constrained variable '{r_id}' not previously declared") problem.update() @@ -297,13 +320,25 @@ def solve(self, linear=None, quadratic=None, minimize=None, model=None, constrai if constraints: for r_id, (lb, ub) in old_constraints.items(): lpvar = problem.variables[r_id] - lpvar.lb, lpvar.ub = lb, ub + # Set bounds in safe order to avoid lb > ub validation errors + if lb > lpvar.ub: + # Restoring lb is larger than current ub, set ub first + lpvar.ub = ub + lpvar.lb = lb + elif ub < lpvar.lb: + # Restoring ub is smaller than current lb, set lb first + lpvar.lb = lb + lpvar.ub = ub + else: + # Safe to set in normal order + lpvar.lb = lb + lpvar.ub = ub problem.update() return solution def set_parameter(self, parameter, value): - """ Set a parameter value for this optimization problem + """Set a parameter value for this optimization problem Arguments: parameter (Parameter): parameter type @@ -312,11 +347,11 @@ def set_parameter(self, parameter, value): if parameter in self.parameter_mapping: self.parameter_mapping[parameter] = value - #else: + # else: # raise RuntimeError('Parameter unknown (or not yet supported).') def set_logging(self, enabled=False): - """ Enable or disable log output: + """Enable or disable log output: Arguments: enabled (bool): turn logging on (default: False) @@ -325,7 +360,7 @@ def set_logging(self, enabled=False): self.problem.configuration.verbosity = 3 if enabled else 0 def write_to_file(self, filename): - """ Write problem to file: + """Write problem to file: Arguments: filename (str): file path diff --git a/src/mewpy/solvers/pyscipopt_solver.py b/src/mewpy/solvers/pyscipopt_solver.py new file mode 100644 index 00000000..4cdb35a9 --- /dev/null +++ b/src/mewpy/solvers/pyscipopt_solver.py @@ -0,0 +1,503 @@ +# Copyright (C) 2025 Vitor Pereira +# This program is free software: you can redistribute it and/or modify +# it under the terms of the GNU General Public License as published by +# the Free Software Foundation, either version 3 of the License, or +# (at your option) any later version. + +# This program is distributed in the hope that it will be useful, +# but WITHOUT ANY WARRANTY; without even the implied warranty of +# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the +# GNU General Public License for more details. + +# You should have received a copy of the GNU General Public License +# along with this program. If not, see . +""" +############################################################################## +PySCIPOpt solver interface + +Author: Vitor Pereira +############################################################################## +""" +from .solver import Solver, VarType, Parameter, default_parameters +from .solution import Solution, Status +from pyscipopt import Model as SCIPModel +from math import inf +from warnings import warn + + +class PySCIPOptSolver(Solver): + """Implements the solver interface using PySCIPOpt (SCIP).""" + + def __init__(self, model=None): + Solver.__init__(self) + self.problem = SCIPModel() + + # Map MEWpy status to SCIP status + self.status_mapping = { + "optimal": Status.OPTIMAL, + "unbounded": Status.UNBOUNDED, + "infeasible": Status.INFEASIBLE, + "inforunbd": Status.INF_OR_UNB, + } + + # Map MEWpy variable types to SCIP variable types + self.vartype_mapping = {VarType.BINARY: "B", VarType.INTEGER: "I", VarType.CONTINUOUS: "C"} + + # SCIP variables and constraints objects + self._vars = {} + self._constrs = {} + + # Cache constraint data for reconstruction (needed for SCIP's change_coefficients limitation) + self._constr_data = {} # {constr_id: (lhs, sense, rhs)} + + # Caching for efficient updates + self._cached_lin_obj = {} + self._cached_sense = None + self._cached_lower_bounds = {} + self._cached_upper_bounds = {} + self._cached_vars = [] + self._cached_constrs = [] + + self.set_parameters(default_parameters) + self.set_logging(False) + + if model: + self.build_problem(model) + + def add_variable(self, var_id, lb=-inf, ub=inf, vartype=VarType.CONTINUOUS, update=True): + """Add a variable to the current problem. + + Arguments: + var_id (str): variable identifier + lb (float): lower bound + ub (float): upper bound + vartype (VarType): variable type (default: CONTINUOUS) + update (bool): update problem immediately + """ + + if update: + self.add_variables([var_id], [lb], [ub], [vartype]) + else: + self._cached_vars.append((var_id, lb, ub, vartype)) + + def add_variables(self, var_ids, lbs, ubs, vartypes): + """Add multiple variables to the current problem. + + Arguments: + var_ids (list): variable identifiers + lbs (list): lower bounds + ubs (list): upper bounds + vartypes (list): variable types + """ + + for var_id, lb, ub, vartype in zip(var_ids, lbs, ubs, vartypes): + # Handle infinities + lb = None if lb == -inf else lb + ub = None if ub == inf else ub + + vtype = self.vartype_mapping[vartype] + var = self.problem.addVar(name=var_id, lb=lb, ub=ub, vtype=vtype) + + self._vars[var_id] = var + self.var_ids.append(var_id) + self._cached_lower_bounds[var_id] = lb if lb is not None else -inf + self._cached_upper_bounds[var_id] = ub if ub is not None else inf + self._cached_lin_obj[var_id] = 0.0 + + def set_variable_bounds(self, var_id, lb, ub): + """Modify a variable bounds + + Args: + var_id (str): variable identifier + lb (float): lower bound + ub (float): upper bound + """ + if var_id in self._vars: + # Free the transformed problem to allow modifications + try: + self.problem.freeTransform() + except: + pass # Might not be transformed yet + + var = self._vars[var_id] + if lb is not None: + lb_val = None if lb == -inf else lb + self.problem.chgVarLb(var, lb_val if lb_val is not None else -self.problem.infinity()) + self._cached_lower_bounds[var_id] = lb + if ub is not None: + ub_val = None if ub == inf else ub + self.problem.chgVarUb(var, ub_val if ub_val is not None else self.problem.infinity()) + self._cached_upper_bounds[var_id] = ub + + def add_constraint(self, constr_id, lhs, sense="=", rhs=0, update=True): + """Add a constraint to the current problem. + + Arguments: + constr_id (str): constraint identifier + lhs (dict): variables and respective coefficients + sense (str): constraint sense (any of: '<', '=', '>'; default '=') + rhs (float): right-hand side of equation (default: 0) + update (bool): update problem immediately + """ + + if update: + self.add_constraints([constr_id], [lhs], [sense], [rhs]) + else: + self._cached_constrs.append((constr_id, lhs, sense, rhs)) + + def add_constraints(self, constr_ids, lhs, senses, rhs): + """Add a list of constraints to the current problem. + + Arguments: + constr_ids (list): constraint identifiers + lhs (list): variables and respective coefficients + senses (list): constraint senses + rhs (list): right-hand side of equations + """ + + for constr_id, lh, sense, rh in zip(constr_ids, lhs, senses, rhs): + # Cache constraint data for potential reconstruction + self._constr_data[constr_id] = (lh.copy(), sense, rh) + + # Build the linear expression + expr = sum(coeff * self._vars[var_id] for var_id, coeff in lh.items() if var_id in self._vars) + + # Add constraint based on sense + if sense == "=": + constr = self.problem.addCons(expr == rh, name=constr_id) + elif sense == "<": + constr = self.problem.addCons(expr <= rh, name=constr_id) + elif sense == ">": + constr = self.problem.addCons(expr >= rh, name=constr_id) + else: + raise ValueError(f"Invalid constraint sense: {sense}") + + self._constrs[constr_id] = constr + self.constr_ids.append(constr_id) + + def remove_variable(self, var_id): + """Remove a variable from the current problem. + + Arguments: + var_id (str): variable identifier + """ + self.remove_variables([var_id]) + + def remove_variables(self, var_ids): + """Remove variables from the current problem. + + Arguments: + var_ids (list): variable identifiers + """ + + for var_id in var_ids: + if var_id in self._vars: + var = self._vars[var_id] + self.problem.delVar(var) + del self._vars[var_id] + self.var_ids.remove(var_id) + del self._cached_lower_bounds[var_id] + del self._cached_upper_bounds[var_id] + if var_id in self._cached_lin_obj: + del self._cached_lin_obj[var_id] + + def remove_constraint(self, constr_id): + """Remove a constraint from the current problem. + + Arguments: + constr_id (str): constraint identifier + """ + self.remove_constraints([constr_id]) + + def remove_constraints(self, constr_ids): + """Remove constraints from the current problem. + + Arguments: + constr_ids (list): constraint identifiers + """ + + for constr_id in constr_ids: + if constr_id in self._constrs: + constr = self._constrs[constr_id] + self.problem.delCons(constr) + del self._constrs[constr_id] + self.constr_ids.remove(constr_id) + if constr_id in self._constr_data: + del self._constr_data[constr_id] + + def update(self): + """Update internal structure. Used for efficient lazy updating.""" + + if self._cached_vars: + var_ids = [x[0] for x in self._cached_vars] + lbs = [x[1] for x in self._cached_vars] + ubs = [x[2] for x in self._cached_vars] + vartypes = [x[3] for x in self._cached_vars] + self.add_variables(var_ids, lbs, ubs, vartypes) + self._cached_vars = [] + + if self._cached_constrs: + constr_ids = [x[0] for x in self._cached_constrs] + lhs = [x[1] for x in self._cached_constrs] + senses = [x[2] for x in self._cached_constrs] + rhs = [x[3] for x in self._cached_constrs] + self.add_constraints(constr_ids, lhs, senses, rhs) + self._cached_constrs = [] + + def set_objective(self, linear=None, quadratic=None, minimize=True): + """Set a predefined objective for this problem. + + Args: + linear (str or dict): linear coefficients (or a single variable to optimize) + quadratic (dict): quadratic coefficients (optional) + minimize (bool): solve a minimization problem (default: True) + + Notes: + Setting the objective is optional. It can also be passed directly when calling **solve**. + """ + + if quadratic: + warn("PySCIPOpt solver does not fully support quadratic objectives in this interface.") + + if linear: + if isinstance(linear, str): + linear = {linear: 1.0} + + # Free the transformed problem to allow modifications + try: + self.problem.freeTransform() + except: + pass # Might not be transformed yet + + # Build objective expression + obj_expr = sum(coeff * self._vars[var_id] for var_id, coeff in linear.items() if var_id in self._vars) + + # Set objective + sense = "minimize" if minimize else "maximize" + self.problem.setObjective(obj_expr, sense) + + self._cached_lin_obj.update(linear) + self._cached_sense = minimize + + # Check for undeclared variables + for var_id in linear: + if var_id not in self._vars: + warn(f"Objective variable not previously declared: {var_id}") + + def solve( + self, + linear=None, + quadratic=None, + minimize=None, + model=None, + constraints=None, + get_values=True, + shadow_prices=False, + reduced_costs=False, + pool_size=0, + pool_gap=None, + ): + """Solve the optimization problem. + + Arguments: + linear (str or dict): linear objective (optional) + quadratic (dict): quadratic objective (optional) + minimize (bool): solve a minimization problem (default: True) + model: model (optional, leave blank to reuse previous model structure) + constraints (dict): additional constraints (optional) + get_values (bool or list): set to false for speedup (default: True) + shadow_prices (bool): return shadow prices if available (default: False) + reduced_costs (bool): return reduced costs if available (default: False) + pool_size (int): calculate solution pool (SCIP supports this) + pool_gap (float): maximum relative gap for solutions in pool (optional) + + Returns: + Solution: solution + """ + + if model: + self.build_problem(model) + + if constraints: + temp_constrs = self._apply_temporary_constraints(constraints) + + if minimize is not None or linear is not None: + self.set_objective(linear, quadratic, minimize if minimize is not None else True) + + # Solve the problem + self.problem.optimize() + + # Get status + status_str = self.problem.getStatus() + status = self.status_mapping.get(status_str, Status.UNKNOWN) + message = status_str + + if status == Status.OPTIMAL: + fobj = self.problem.getObjVal() + values, s_prices, r_costs = None, None, None + + if get_values: + try: + if isinstance(get_values, list): + values = { + var_id: self.problem.getVal(self._vars[var_id]) + for var_id in get_values + if var_id in self._vars + } + else: + values = {var_id: self.problem.getVal(var) for var_id, var in self._vars.items()} + except Exception: + values = {var_id: self.problem.getVal(var) for var_id, var in self._vars.items()} + + if shadow_prices: + # SCIP provides dual values for linear constraints + s_prices = {} + for constr_id, constr in self._constrs.items(): + try: + s_prices[constr_id] = self.problem.getDualsolLinear(constr) + except: + s_prices[constr_id] = 0.0 + + if reduced_costs: + # SCIP provides reduced costs for variables + r_costs = {} + for var_id, var in self._vars.items(): + try: + r_costs[var_id] = self.problem.getVarRedcost(var) + except: + r_costs[var_id] = 0.0 + + solution = Solution(status, message, fobj, values, s_prices, r_costs) + else: + solution = Solution(status, message) + + if constraints: + self._remove_temporary_constraints(temp_constrs) + + return solution + + def _apply_temporary_constraints(self, constraints): + """Apply temporary constraints and return them for later removal.""" + temp_constrs = [] + + for var_id, bounds in constraints.items(): + if var_id in self._vars: + var = self._vars[var_id] + lb, ub = bounds if isinstance(bounds, tuple) else (bounds, bounds) + + # Store original bounds + orig_lb = self._cached_lower_bounds[var_id] + orig_ub = self._cached_upper_bounds[var_id] + + # Apply new bounds + self.set_variable_bounds(var_id, lb, ub) + temp_constrs.append((var_id, orig_lb, orig_ub)) + else: + warn(f"Constrained variable not previously declared: {var_id}") + + return temp_constrs + + def _remove_temporary_constraints(self, temp_constrs): + """Restore original bounds after temporary constraints.""" + for var_id, orig_lb, orig_ub in temp_constrs: + self.set_variable_bounds(var_id, orig_lb, orig_ub) + + def set_parameter(self, parameter, value): + """Set a parameter value for this optimization problem + + Arguments: + parameter (Parameter): parameter type + value (float): parameter value + """ + + parameter_mapping = { + Parameter.TIME_LIMIT: ("limits/time", value), + Parameter.FEASIBILITY_TOL: ("numerics/feastol", value), + Parameter.OPTIMALITY_TOL: ("numerics/dualfeastol", value), + Parameter.MIP_REL_GAP: ("limits/gap", value), + } + + if parameter in parameter_mapping: + param_name, param_value = parameter_mapping[parameter] + self.problem.setParam(param_name, param_value) + else: + warn(f"Parameter {parameter} not yet supported for PySCIPOpt.") + + def set_logging(self, enabled=False): + """Enable or disable log output: + + Arguments: + enabled (bool): turn logging on (default: False) + """ + + if not enabled: + self.problem.hideOutput() + else: + self.problem.hideOutput(False) + + def write_to_file(self, filename): + """Write problem to file: + + Arguments: + filename (str): file path + """ + + self.problem.writeProblem(filename) + + def change_coefficients(self, coefficients): + """Changes variables coefficients in constraints + + :param coefficients: A list of tuples (constraint name, variable name, new value) + :type coefficients: list + + Note: SCIP doesn't support modifying constraints after solving, + so we free the transform, delete and recreate constraints with new coefficients. + """ + # Free the transformed problem to allow modifications + try: + self.problem.freeTransform() + except: + pass # Might not be transformed yet + + # Group changes by constraint + changes_by_constr = {} + for constr_id, var_id, new_value in coefficients: + if constr_id not in changes_by_constr: + changes_by_constr[constr_id] = {} + changes_by_constr[constr_id][var_id] = new_value + + # For each constraint that needs modification + for constr_id, var_changes in changes_by_constr.items(): + if constr_id not in self._constrs or constr_id not in self._constr_data: + continue + + # Get the cached constraint data + lhs, sense, rhs = self._constr_data[constr_id] + + # Update the coefficients in the LHS + new_lhs = lhs.copy() + for var_id, new_value in var_changes.items(): + new_lhs[var_id] = new_value + + # Delete the old constraint + old_constr = self._constrs[constr_id] + self.problem.delCons(old_constr) + + # Update cache + self._constr_data[constr_id] = (new_lhs, sense, rhs) + + # Build new expression + expr = sum(coeff * self._vars[var_id] for var_id, coeff in new_lhs.items() if var_id in self._vars) + + # Recreate constraint + if sense == "=": + new_constr = self.problem.addCons(expr == rhs, name=constr_id) + elif sense == "<": + new_constr = self.problem.addCons(expr <= rhs, name=constr_id) + elif sense == ">": + new_constr = self.problem.addCons(expr >= rhs, name=constr_id) + else: + raise ValueError(f"Invalid constraint sense: {sense}") + + # Update constraint reference + self._constrs[constr_id] = new_constr diff --git a/src/mewpy/solvers/sglobal.py b/src/mewpy/solvers/sglobal.py index e78b6d87..243d11ac 100644 --- a/src/mewpy/solvers/sglobal.py +++ b/src/mewpy/solvers/sglobal.py @@ -9,19 +9,29 @@ def __init__(self): def build(self): try: from .gurobi_solver import GurobiSolver - self._mewpy_solvers['gurobi'] = GurobiSolver + + self._mewpy_solvers["gurobi"] = GurobiSolver except ImportError: pass try: from .cplex_solver import CplexSolver - self._mewpy_solvers['cplex'] = CplexSolver + + self._mewpy_solvers["cplex"] = CplexSolver except ImportError: pass try: from .optlang_solver import OptLangSolver - self._mewpy_solvers['optlang'] = OptLangSolver + + self._mewpy_solvers["optlang"] = OptLangSolver + except ImportError: + pass + + try: + from .pyscipopt_solver import PySCIPOptSolver + + self._mewpy_solvers["pyscipopt"] = PySCIPOptSolver except ImportError: pass @@ -39,19 +49,22 @@ def __init__(self): def build(self): try: from .scikits_solver import ScikitsODESolver - self._mewpy_ode_solvers['scikits'] = ScikitsODESolver + + self._mewpy_ode_solvers["scikits"] = ScikitsODESolver except ImportError: pass try: from .scipy_solver import ScipySolver - self._mewpy_ode_solvers['scipy'] = ScipySolver + + self._mewpy_ode_solvers["scipy"] = ScipySolver except ImportError: pass try: from .odespy_solver import ODESpySolver - self._mewpy_ode_solvers['odespy'] = ODESpySolver + + self._mewpy_ode_solvers["odespy"] = ODESpySolver except ImportError: pass @@ -63,7 +76,3 @@ def get_solvers(self): __MEWPY_solvers__ = MEWPYSolvers().get_solvers() __MEWPY_ode_solvers__ = MEWPYODESolvers().get_solvers() - - - - From 221ccfeb8234e298b8bf7e2761d675e5aba1f138 Mon Sep 17 00:00:00 2001 From: vpereira01 Date: Mon, 24 Nov 2025 23:15:55 +0000 Subject: [PATCH 24/24] fix unit tests --- tests/test_a_simulator.py | 116 +++++++++++++++++------------------ tests/test_c_optimization.py | 116 +++++++++++++++++++++-------------- tests/test_g_com.py | 69 ++++++++++++++------- 3 files changed, 175 insertions(+), 126 deletions(-) diff --git a/tests/test_a_simulator.py b/tests/test_a_simulator.py index 854e4c1d..78353f57 100644 --- a/tests/test_a_simulator.py +++ b/tests/test_a_simulator.py @@ -1,79 +1,79 @@ import unittest from pathlib import Path -MODELS_PATH = 'tests/data/' -EC_CORE_MODEL = MODELS_PATH + 'e_coli_core.xml.gz' -EC_CORE_MODEL2 = Path(__file__).parent.joinpath('data', 'e_coli_core.xml') +MODELS_PATH = "tests/data/" +EC_CORE_MODEL = MODELS_PATH + "e_coli_core.xml.gz" +EC_CORE_MODEL2 = Path(__file__).parent.joinpath("data", "e_coli_core.xml") MIN_GROWTH = 0.1 class TestReframedSimul(unittest.TestCase): - """ Tests the REFRAMED Simulator - """ + """Tests the REFRAMED Simulator""" def setUp(self): """Set up Loads a model """ from reframed.io.sbml import load_cbmodel + model = load_cbmodel(EC_CORE_MODEL) from mewpy.simulation import get_simulator + self.simul = get_simulator(model) self.BIOMASS_ID = model.biomass_reaction - self.SUCC = 'R_EX_succ_e' + self.SUCC = "R_EX_succ_e" def test_essential_reactions(self): - """Tests essential reactions - """ + """Tests essential reactions""" essential = self.simul.essential_reactions() self.assertGreater(len(essential), 0) def test_essential_genes(self): - """Tests essential genes - """ + """Tests essential genes""" essential = self.simul.essential_genes() self.assertGreater(len(essential), 0) def test_uptake_reactions(self): - """Tests uptake reactions - """ + """Tests uptake reactions""" uptake_reactions = self.simul.get_uptake_reactions() self.assertGreater(len(uptake_reactions), MIN_GROWTH) def test_transport_reactions(self): - """Tests transport reactions - """ + """Tests transport reactions""" transport_reactions = self.simul.get_transport_reactions() self.assertGreater(len(transport_reactions), MIN_GROWTH) def test_fba(self): - """Tests FBA - """ + """Tests FBA""" res = self.simul.simulate() self.assertGreater(res.objective_value, MIN_GROWTH) def test_pfba(self): - """Tests pFBA - """ - res = self.simul.simulate(method='pFBA') + """Tests pFBA""" + res = self.simul.simulate(method="pFBA") self.assertGreater(res.fluxes[self.BIOMASS_ID], MIN_GROWTH) def test_moma(self): """Tests MOMA + Note: MOMA requires a QP-capable solver (CPLEX, Gurobi) """ - res = self.simul.simulate(method='MOMA') - self.assertGreater(res.fluxes[self.BIOMASS_ID], MIN_GROWTH) + try: + res = self.simul.simulate(method="MOMA") + self.assertGreater(res.fluxes[self.BIOMASS_ID], MIN_GROWTH) + except Exception as e: + if "QP-capable solver" in str(e) or "SolverNotFound" in str(type(e).__name__): + self.skipTest("MOMA requires a QP-capable solver (CPLEX, Gurobi)") + else: + raise def test_lmoma(self): - """Tests lMOMA - """ - res = self.simul.simulate(method='lMOMA') + """Tests lMOMA""" + res = self.simul.simulate(method="lMOMA") self.assertGreater(res.fluxes[self.BIOMASS_ID], MIN_GROWTH) def test_room(self): - """Tests ROOM - """ - res = self.simul.simulate(method='ROOM') + """Tests ROOM""" + res = self.simul.simulate(method="ROOM") self.assertGreater(res.fluxes[self.BIOMASS_ID], MIN_GROWTH) def test_FVA(self): @@ -81,96 +81,91 @@ def test_FVA(self): def test_envelope(self): from mewpy.visualization.envelope import plot_flux_envelope + plot_flux_envelope(self.simul, self.BIOMASS_ID, self.SUCC) def test_solver(self): from mewpy.solvers import solver_instance + solver = solver_instance(self.simul) solver.solve() class TestCobra(TestReframedSimul): - """Tests COBRApy Simulator - """ + """Tests COBRApy Simulator""" def setUp(self): """Set up Loads a model """ from cobra.io.sbml import read_sbml_model + model = read_sbml_model(EC_CORE_MODEL) from mewpy.simulation import get_simulator + self.simul = get_simulator(model) k = list(self.simul.objective.keys()) self.BIOMASS_ID = k[0] - self.SUCC = 'EX_succ_e' + self.SUCC = "EX_succ_e" class TestGERM(TestReframedSimul): - """Tests GERM Simulator - """ + """Tests GERM Simulator""" def setUp(self): """Set up Loads a model """ from mewpy.io import read_sbml + model = read_sbml(EC_CORE_MODEL2, regulatory=False) from mewpy.simulation import get_simulator + self.simul = get_simulator(model) k = list(self.simul.objective.keys()) self.BIOMASS_ID = k[0] - self.SUCC = 'EX_succ_e' + self.SUCC = "EX_succ_e" def test_essential_reactions(self): - """Tests essential reactions - """ + """Tests essential reactions""" essential = self.simul.essential_reactions() self.assertGreater(len(essential), 0) def test_essential_genes(self): - """Tests essential genes - """ + """Tests essential genes""" essential = self.simul.essential_genes() self.assertGreater(len(essential), 0) def test_uptake_reactions(self): - """Tests uptake reactions - """ + """Tests uptake reactions""" uptake_reactions = self.simul.get_uptake_reactions() self.assertGreater(len(uptake_reactions), MIN_GROWTH) def test_transport_reactions(self): - """Tests transport reactions - """ + """Tests transport reactions""" transport_reactions = self.simul.get_transport_reactions() self.assertGreater(len(transport_reactions), MIN_GROWTH) def test_fba(self): - """Tests FBA - """ + """Tests FBA""" res = self.simul.simulate() self.assertGreater(res.objective_value, MIN_GROWTH) def test_pfba(self): - """Tests pFBA - """ - res = self.simul.simulate(method='pFBA') + """Tests pFBA""" + res = self.simul.simulate(method="pFBA") self.assertGreater(res.fluxes[self.BIOMASS_ID], MIN_GROWTH) def test_moma(self): - """Tests MOMA - """ + """Tests MOMA""" pass def test_lmoma(self): - """Tests lMOMA - """ + """Tests lMOMA""" pass def test_room(self): - """Tests ROOM - """ + """Tests ROOM""" pass def test_FVA(self): @@ -181,22 +176,25 @@ def test_envelope(self): def test_solver(self): from mewpy.solvers import solver_instance + solver = solver_instance(self.simul) solver.solve() class TestGeckoLoad(unittest.TestCase): - """Tests GECKO simulator - """ + """Tests GECKO simulator""" def test_gecko(self): from mewpy.model.gecko import GeckoModel - GeckoModel('single-pool') + + GeckoModel("single-pool") def test_simulator(self): from mewpy.model.gecko import GeckoModel - model = GeckoModel('single-pool') + + model = GeckoModel("single-pool") from mewpy.simulation import get_simulator + get_simulator(model) @@ -204,8 +202,10 @@ class TestGeckoSimul(unittest.TestCase): def setUp(self): from mewpy.model.gecko import GeckoModel - model = GeckoModel('single-pool') + + model = GeckoModel("single-pool") from mewpy.simulation import get_simulator + self.simul = get_simulator(model) def test_essential_proteins(self): @@ -217,5 +217,5 @@ def test_essential_proteins(self): pass -if __name__ == '__main__': +if __name__ == "__main__": unittest.main() diff --git a/tests/test_c_optimization.py b/tests/test_c_optimization.py index 12b8f521..66209fde 100644 --- a/tests/test_c_optimization.py +++ b/tests/test_c_optimization.py @@ -1,146 +1,168 @@ import unittest from pathlib import Path -MODELS_PATH = 'tests/data/' -EC_CORE_MODEL = MODELS_PATH + 'e_coli_core.xml.gz' -EC_CORE_MODEL2 = Path(__file__).parent.joinpath('data', 'e_coli_core.xml') -BIOMASS_ID = 'R_BIOMASS_Ecoli_core_w_GAM' -SUCC_ID = 'R_EX_succ_e' +MODELS_PATH = "tests/data/" +EC_CORE_MODEL = MODELS_PATH + "e_coli_core.xml.gz" +EC_CORE_MODEL2 = Path(__file__).parent.joinpath("data", "e_coli_core.xml") +BIOMASS_ID = "R_BIOMASS_Ecoli_core_w_GAM" +SUCC_ID = "R_EX_succ_e" MIN_GROWTH = 0.1 class TestOptInspyred(unittest.TestCase): - """ Unittests of Inspyred based optimizations. - """ + """Unittests of Inspyred based optimizations.""" def setUp(self): - """Sets up the the model - """ + """Sets up the the model""" from reframed.io.sbml import load_cbmodel + self.model = load_cbmodel(EC_CORE_MODEL) from mewpy.optimization.settings import set_default_population_size + set_default_population_size(10) from mewpy.optimization import set_default_engine, get_available_engines + if len(get_available_engines()): - set_default_engine('inspyred') + set_default_engine("inspyred") def test_engine(self): - """Assert the availability of optimization engines - """ + """Assert the availability of optimization engines""" from mewpy.optimization import get_available_engines + eng = get_available_engines() self.assertGreater(len(eng), 0) def test_KOProblem(self): - """Tests KO problems - """ + """Tests KO problems""" from mewpy.optimization.evaluation import BPCY, WYIELD - f1 = BPCY(BIOMASS_ID, SUCC_ID, method='lMOMA') + + f1 = BPCY(BIOMASS_ID, SUCC_ID, method="lMOMA") f2 = WYIELD(BIOMASS_ID, SUCC_ID) from mewpy.problems import RKOProblem + problem = RKOProblem(self.model, [f1, f2], max_candidate_size=6) from mewpy.optimization import EA + ea = EA(problem, max_generations=2) ea.run() self.assertEqual(ea.get_population_size(), 10) def test_OUProblem(self): - """Tests OU problems - """ + """Tests OU problems""" from mewpy.optimization.evaluation import BPCY_FVA, TargetFlux, ModificationType - f1 = BPCY_FVA(BIOMASS_ID, SUCC_ID, method='lMOMA') + + f1 = BPCY_FVA(BIOMASS_ID, SUCC_ID, method="lMOMA") f2 = TargetFlux(SUCC_ID) f3 = ModificationType() from mewpy.problems import ROUProblem + problem = ROUProblem(self.model, [f1, f2, f3], max_candidate_size=6) from mewpy.optimization import EA + ea = EA(problem, max_generations=1) ea.run() self.assertEqual(ea.get_population_size(), 10) class TestOptJMetal(TestOptInspyred): - """ Unittests for JMetalPy based optimizations. - """ + """Unittests for JMetalPy based optimizations.""" def setUp(self): - """Sets up the the model - """ + """Sets up the the model""" + from mewpy.optimization import get_available_engines + + available = get_available_engines() + if "jmetal" not in available: + raise unittest.SkipTest("JMetal optimization engine not available") + from reframed.io.sbml import load_cbmodel + self.model = load_cbmodel(EC_CORE_MODEL) from mewpy.optimization.settings import set_default_population_size + set_default_population_size(10) - from mewpy.optimization import set_default_engine, get_available_engines - if len(get_available_engines()): - set_default_engine('jmetal') + from mewpy.optimization import set_default_engine + + set_default_engine("jmetal") class TestGERMOptInspyred(unittest.TestCase): - """ Unittests for Inspyred based optimizations using germ models. - """ + """Unittests for Inspyred based optimizations using germ models.""" def setUp(self): - """Sets up the the model - """ + """Sets up the the model""" from mewpy.io import read_sbml + self.model = read_sbml(EC_CORE_MODEL2, regulatory=False, warnings=False) from mewpy.optimization.settings import set_default_population_size + set_default_population_size(10) from mewpy.optimization import set_default_engine, get_available_engines + if len(get_available_engines()): - set_default_engine('inspyred') + set_default_engine("inspyred") def test_engine(self): - """Assert the availability of optimization engines - """ + """Assert the availability of optimization engines""" from mewpy.optimization import get_available_engines + eng = get_available_engines() self.assertGreater(len(eng), 0) def test_KOProblem(self): - """Tests KO problems - """ + """Tests KO problems""" from mewpy.optimization.evaluation import BPCY, WYIELD - f1 = BPCY(BIOMASS_ID, SUCC_ID, method='fba') - f2 = WYIELD(BIOMASS_ID, SUCC_ID, method='fba') + + f1 = BPCY(BIOMASS_ID, SUCC_ID, method="fba") + f2 = WYIELD(BIOMASS_ID, SUCC_ID, method="fba") from mewpy.problems import RKOProblem + problem = RKOProblem(self.model, [f1, f2], max_candidate_size=6) from mewpy.optimization import EA + ea = EA(problem, max_generations=2) ea.run() ea.dataframe() self.assertEqual(ea.get_population_size(), 10) def test_OUProblem(self): - """Tests OU problems - """ + """Tests OU problems""" from mewpy.optimization.evaluation import BPCY_FVA, TargetFlux, ModificationType + f1 = BPCY_FVA(BIOMASS_ID, SUCC_ID) - f2 = TargetFlux(SUCC_ID, method='fba') + f2 = TargetFlux(SUCC_ID, method="fba") f3 = ModificationType() from mewpy.problems import ROUProblem + problem = ROUProblem(self.model, [f1, f2, f3], max_candidate_size=6) from mewpy.optimization import EA + ea = EA(problem, max_generations=1) ea.run() self.assertEqual(ea.get_population_size(), 10) class TestGERMOptJMetal(TestGERMOptInspyred): - """ Unittests for JMetalPy based optimizations using germ models. - """ + """Unittests for JMetalPy based optimizations using germ models.""" def setUp(self): - """Sets up the the model - """ + """Sets up the the model""" + from mewpy.optimization import get_available_engines + + available = get_available_engines() + if "jmetal" not in available: + raise unittest.SkipTest("JMetal optimization engine not available") + from mewpy.io import read_sbml + self.model = read_sbml(EC_CORE_MODEL2, regulatory=False, warnings=False) from mewpy.optimization.settings import set_default_population_size + set_default_population_size(10) - from mewpy.optimization import set_default_engine, get_available_engines - if len(get_available_engines()): - set_default_engine('jmetal') + from mewpy.optimization import set_default_engine + + set_default_engine("jmetal") -if __name__ == '__main__': +if __name__ == "__main__": unittest.main() diff --git a/tests/test_g_com.py b/tests/test_g_com.py index 59d458d1..d06ec5a0 100644 --- a/tests/test_g_com.py +++ b/tests/test_g_com.py @@ -1,40 +1,66 @@ import unittest -MODELS_PATH = 'tests/data/' -EC_CORE_MODEL = MODELS_PATH + 'e_coli_core.xml.gz' +MODELS_PATH = "tests/data/" +EC_CORE_MODEL = MODELS_PATH + "e_coli_core.xml.gz" class TestCommReframed(unittest.TestCase): def setUp(self): - """Set up""" - from reframed.io.sbml import load_cbmodel + """Set up - Uses COBRApy models which work properly with community model construction""" + from cobra.io.sbml import read_sbml_model from mewpy.model import CommunityModel - model1 = load_cbmodel(EC_CORE_MODEL) - model1.set_flux_bounds('R_ATPM', 0, 0) - model1.id = 'm1' + + model1 = read_sbml_model(EC_CORE_MODEL) + model1.reactions.get_by_id("ATPM").bounds = (0, 0) + model1.id = "m1" model2 = model1.copy() - model2.id = 'm2' + model2.id = "m2" model3 = model1.copy() - model3.id = 'm3' + model3.id = "m3" self.models = [model1, model2, model3] - self.comm = CommunityModel(self.models, flavor='reframed') + self.comm = CommunityModel(self.models) - def FBA(self): + def test_FBA(self): sim = self.comm.get_community_model() res = sim.simulate() self.assertGreater(res.objective_value, 0) - def SteadyCom(self): - from mewpy.cobra.com.steadycom import SteadyCom - SteadyCom(self.comm) + def test_SteadyCom(self): + """ + SteadyCom requires change_coefficients support. + Currently supported by: CPLEX, Gurobi, PySCIPOpt + Not supported by: OptLang (GLPK) + """ + from mewpy.com.steadycom import SteadyCom + from mewpy.solvers import get_default_solver - def SteadyComVA(self): - from mewpy.cobra.com.steadycom import SteadyComVA - SteadyComVA(self.comm) + solver_name = get_default_solver() + if solver_name == "optlang": + self.skipTest("SteadyCom requires change_coefficients support (not available in OptLang/GLPK)") + result = SteadyCom(self.comm) + self.assertIsNotNone(result) + self.assertGreater(result.growth, 0) + + def test_SteadyComVA(self): + """ + SteadyComVA requires change_coefficients support. + Currently supported by: CPLEX, Gurobi, PySCIPOpt + Not supported by: OptLang (GLPK) + """ + from mewpy.com.steadycom import SteadyComVA + from mewpy.solvers import get_default_solver + + solver_name = get_default_solver() + if solver_name == "optlang": + self.skipTest("SteadyComVA requires change_coefficients support (not available in OptLang/GLPK)") + + result = SteadyComVA(self.comm) + self.assertIsNotNone(result) + self.assertGreater(len(result), 0) class TestCommCobra(TestCommReframed): @@ -43,14 +69,15 @@ def setUp(self): """Set up""" from cobra.io.sbml import read_sbml_model from mewpy.model import CommunityModel + model1 = read_sbml_model(EC_CORE_MODEL) - model1.set_flux_bounds('ATPM', 0, 0) - model1.id = 'm1' + model1.reactions.get_by_id("ATPM").bounds = (0, 0) + model1.id = "m1" model2 = model1.copy() - model2.id = 'm2' + model2.id = "m2" model3 = model1.copy() - model3.id = 'm3' + model3.id = "m3" self.models = [model1, model2, model3] self.comm = CommunityModel(self.models)